Effects of aging in catastrophe on the steady state and dynamics of a microtubule population

NASA Astrophysics Data System (ADS)

Jemseena, V.; Gopalakrishnan, Manoj

2015-05-01

Several independent observations have suggested that the catastrophe transition in microtubules is not a first-order process, as is usually assumed. Recent in vitro observations by Gardner et al. [M. K. Gardner et al., Cell 147, 1092 (2011), 10.1016/j.cell.2011.10.037] showed that microtubule catastrophe takes place via multiple steps and the frequency increases with the age of the filament. Here we investigate, via numerical simulations and mathematical calculations, some of the consequences of the age dependence of catastrophe on the dynamics of microtubules as a function of the aging rate, for two different models of aging: exponential growth, but saturating asymptotically, and purely linear growth. The boundary demarcating the steady-state and non-steady-state regimes in the dynamics is derived analytically in both cases. Numerical simulations, supported by analytical calculations in the linear model, show that aging leads to nonexponential length distributions in steady state. More importantly, oscillations ensue in microtubule length and velocity. The regularity of oscillations, as characterized by the negative dip in the autocorrelation function, is reduced by increasing the frequency of rescue events. Our study shows that the age dependence of catastrophe could function as an intrinsic mechanism to generate oscillatory dynamics in a microtubule population, distinct from hitherto identified ones.

Relaxation from Steady States Far from Equilibrium and the Persistence of Anomalous Shock Behavior in Weakly Ionized Gases

NASA Technical Reports Server (NTRS)

Rubinstein, Robert; Auslender, Aaron H.

1999-01-01

The decay of anomalous effects on shock waves in weakly ionized gases following plasma generator extinction has been measured in the anticipation that the decay time must correlate well with the relaxation time of the mechanism responsible for the anomalous effects. When the relaxation times cannot be measured directly, they are inferred theoretically, usually assuming that the initial state is nearly in thermal equilibrium. In this paper, it is demonstrated that relaxation from any steady state far from equilibrium, including the state of a weakly ionized gas, can proceed much more slowly than arguments based on relaxation from near equilibrium states might suggest. This result justifies a more careful analysis of the relaxation times in weakly ionized gases and suggests that although the experimental measurements of relaxation times did not lead to an unambiguous conclusion, this approach to understanding the anomalous effects may warrant further investigation.

Rocket Engine Nozzle Side Load Transient Analysis Methodology: A Practical Approach

NASA Technical Reports Server (NTRS)

Shi, John J.

2005-01-01

During the development stage, in order to design/to size the rocket engine components and to reduce the risks, the local dynamic environments as well as dynamic interface loads must be defined. There are two kinds of dynamic environment, i.e. shock transients and steady-state random and sinusoidal vibration environments. Usually, the steady-state random and sinusoidal vibration environments are scalable, but the shock environments are not scalable. In other words, based on similarities only random vibration environments can be defined for a new engine. The methodology covered in this paper provides a way to predict the shock environments and the dynamic loads for new engine systems and new engine components in the early stage of new engine development or engine nozzle modifications.

A straightforward method to compute average stochastic oscillations from data samples.

PubMed

Júlvez, Jorge

2015-10-19

Many biological systems exhibit sustained stochastic oscillations in their steady state. Assessing these oscillations is usually a challenging task due to the potential variability of the amplitude and frequency of the oscillations over time. As a result of this variability, when several stochastic replications are averaged, the oscillations are flattened and can be overlooked. This can easily lead to the erroneous conclusion that the system reaches a constant steady state. This paper proposes a straightforward method to detect and asses stochastic oscillations. The basis of the method is in the use of polar coordinates for systems with two species, and cylindrical coordinates for systems with more than two species. By slightly modifying these coordinate systems, it is possible to compute the total angular distance run by the system and the average Euclidean distance to a reference point. This allows us to compute confidence intervals, both for the average angular speed and for the distance to a reference point, from a set of replications. The use of polar (or cylindrical) coordinates provides a new perspective of the system dynamics. The mean trajectory that can be obtained by averaging the usual cartesian coordinates of the samples informs about the trajectory of the center of mass of the replications. In contrast to such a mean cartesian trajectory, the mean polar trajectory can be used to compute the average circular motion of those replications, and therefore, can yield evidence about sustained steady state oscillations. Both, the coordinate transformation and the computation of confidence intervals, can be carried out efficiently. This results in an efficient method to evaluate stochastic oscillations.

Ribosome flow model with positive feedback

PubMed Central

Margaliot, Michael; Tuller, Tamir

2013-01-01

Eukaryotic mRNAs usually form a circular structure; thus, ribosomes that terminatae translation at the 3′ end can diffuse with increased probability to the 5′ end of the transcript, initiating another cycle of translation. This phenomenon describes ribosomal flow with positive feedback—an increase in the flow of ribosomes terminating translating the open reading frame increases the ribosomal initiation rate. The aim of this paper is to model and rigorously analyse translation with feedback. We suggest a modified version of the ribosome flow model, called the ribosome flow model with input and output. In this model, the input is the initiation rate and the output is the translation rate. We analyse this model after closing the loop with a positive linear feedback. We show that the closed-loop system admits a unique globally asymptotically stable equilibrium point. From a biophysical point of view, this means that there exists a unique steady state of ribosome distributions along the mRNA, and thus a unique steady-state translation rate. The solution from any initial distribution will converge to this steady state. The steady-state distribution demonstrates a decrease in ribosome density along the coding sequence. For the case of constant elongation rates, we obtain expressions relating the model parameters to the equilibrium point. These results may perhaps be used to re-engineer the biological system in order to obtain a desired translation rate. PMID:23720534

A Robust and Efficient Method for Steady State Patterns in Reaction-Diffusion Systems

PubMed Central

Lo, Wing-Cheong; Chen, Long; Wang, Ming; Nie, Qing

2012-01-01

An inhomogeneous steady state pattern of nonlinear reaction-diffusion equations with no-flux boundary conditions is usually computed by solving the corresponding time-dependent reaction-diffusion equations using temporal schemes. Nonlinear solvers (e.g., Newton’s method) take less CPU time in direct computation for the steady state; however, their convergence is sensitive to the initial guess, often leading to divergence or convergence to spatially homogeneous solution. Systematically numerical exploration of spatial patterns of reaction-diffusion equations under different parameter regimes requires that the numerical method be efficient and robust to initial condition or initial guess, with better likelihood of convergence to an inhomogeneous pattern. Here, a new approach that combines the advantages of temporal schemes in robustness and Newton’s method in fast convergence in solving steady states of reaction-diffusion equations is proposed. In particular, an adaptive implicit Euler with inexact solver (AIIE) method is found to be much more efficient than temporal schemes and more robust in convergence than typical nonlinear solvers (e.g., Newton’s method) in finding the inhomogeneous pattern. Application of this new approach to two reaction-diffusion equations in one, two, and three spatial dimensions, along with direct comparisons to several other existing methods, demonstrates that AIIE is a more desirable method for searching inhomogeneous spatial patterns of reaction-diffusion equations in a large parameter space. PMID:22773849

Four possible types of pulses for self-induced transparency

NASA Technical Reports Server (NTRS)

Lee, C. T.

1974-01-01

Four types of steady-state solutions were derived for the coupled Maxwell-Bloch equations which describe highly intense pulse propagation in a resonant medium. Essential in the derivation procedures is the replacement of the usual slowly varying envelope approximation with an alternative procedure, the omission of possible nonresonant losses, and the assumption that the relaxation times are infinite.

Characteristics of dioxin emissions at startup and shutdown of MSW incinerators.

PubMed

Tejima, Hajime; Nishigaki, Masahide; Fujita, Yasuyuki; Matsumoto, Akihiro; Takeda, Nobuo; Takaoka, Masaki

2007-01-01

Dioxin concentrations from municipal waste incinerators in Japan and elsewhere often show low concentrations that comply with legal limits (in this paper, the term "dioxin" designates WHO-TEQ: PCDD/Fs+dioxin-like PCB). However, such data is usually generated under normal steady state operational conditions, and there has been little investigation of releases occurring during startup and shutdown. It is important, therefore, to ascertain quantitatively emissions in an unsteady state (startup and shutdown) in order to correctly evaluate the relationship between emissions from a facility and the surrounding environment. The present study aimed to examine dioxin emissions of a continuously operated incinerator at startup and shutdown, and estimating the time period of greatest emission, and the processes causing dioxin generation. The startup process was divided into five stages and the shutdown into two; at each stage, dioxins in the flue gas were measured at the boiler outlet and the stack. From the concentration of dioxins and the flue gas volume at each stage, the amount of dioxins at startup and shutdown were calculated, and these were compared with that under steady state conditions. Dioxin concentration at the stack under steady state conditions was a very low level, while those at startup and shutdown were higher. In the case where dioxin concentration under a steady state is a low level like in this study, it is indicated that the total annual dioxin emission from a facility could be attributed to the startup periods.

The effects of sampling location and turbulence on discharge estimates in short converging turbine intakes

DOE Office of Scientific and Technical Information (OSTI.GOV)

Romero-Gomez, P.; Harding, S. F.; Richmond, M. C.

2017-01-01

Standards provide recommendations for best practices when installing current meters to measure fluid flow in closed conduits. A central guideline requires the velocity distribution to be regular and the flow steady. Because of the nature of the short converging intakes typical of low-head hydroturbines, these assumptions may be invalid if current meters are intended to be used to estimate discharge. Usual concerns are (1) the effects of the number of devices, (2) the sampling location and (3) the high turbulence caused by blockage from submersible traveling screens usually deployed for safe downstream fish passage. These three effects were examined inmore » the present study by using 3D simulated flow fields in both steady-state and transient modes. In the process of describing an application at an existing hydroturbine intake at Ice Harbor Dam, the present work outlined the methods involved, which combined computational fluid dynamics, laboratory measurements in physical models of the hydroturbine, and current meter performance evaluations in experimental settings. The main conclusions in this specific application were that a steady-state flow field sufficed to determine the adequate number of meters and their location, and that both the transverse velocity and turbulence intensity had a small impact on estimate errors. However, while it may not be possible to extrapolate these findings to other field conditions and measuring devices, the study laid out a path to conduct similar assessments in other applications.« less

Movement-related and steady-state electromyographic activity of human elbow flexors in slow transition movements between two equilibrium states.

PubMed

Tal'nov, A N; Cherkassky, V L; Kostyukov, A I

1997-08-01

The electromyograms were recorded in healthy human subjects by surface electrodes from the mm. biceps brachii (caput longum et. brevis), brachioradialis, and triceps brachii (caput longum) during slow transition movements in elbow joint against a weak extending torque. The test movements (flexion transitions between two steady-states) were fulfilled under visual control through combining on a monitor screen a signal from a joint angle sensor with a corresponding command generated by a computer. Movement velocities ranged between 5 and 80 degrees/s, subjects were asked to move forearm without activation of elbow extensors. Surface electromyograms were full-wave rectified, filtered and averaged within sets of 10 identical tests. Amplitudes of dynamic and steady-state components of the electromyograms were determined in dependence on a final value of joint angle, slow and fast movements were compared. An exponential-like increase of dynamic component was observed in electromyograms recorded from m. biceps brachii, the component had been increased with movement velocity and with load increment. In many experiments a statistically significant decrease of static component could be noticed within middle range of joint angles (40-60 degrees) followed by a well expressed increment for larger movements. This pattern of the static component in electromyograms could vary in different experiments even in the same subjects. A steady discharge in m. brachioradialis at ramp phase has usually been recorded only under a notable load. Variable and quite often unpredictable character of the static components of the electromyograms recorded from elbow flexors in the transition movements makes it difficult to use the equilibrium point hypothesis to describe the central processes of movement. It has been assumed that during active muscle shortening the dynamic components in arriving efferent activity should play a predominant role. A simple scheme could be proposed for transition to a steady-state after shortening. Decrease of the efferent inflow can evoke internal lengthening of the contractile elements in muscle and, as a result, hysteresis increase in the muscle contraction efficiency. Effectiveness in maintenance of the steady position seems to also be enhanced due to muscle thixotropy and friction processes in the joint. Hysteresis after-effects in elbow flexors were demonstrated as a difference in steady-state levels of electromyograms with oppositely directed approaches to the same joint position.

The need to consider temporal variability when modelling exchange at the sediment-water interface

USGS Publications Warehouse

Rosenberry, Donald O.

2011-01-01

Most conceptual or numerical models of flows and processes at the sediment-water interface assume steady-state conditions and do not consider temporal variability. The steady-state assumption is required because temporal variability, if quantified at all, is usually determined on a seasonal or inter-annual scale. In order to design models that can incorporate finer-scale temporal resolution we first need to measure variability at a finer scale. Automated seepage meters that can measure flow across the sediment-water interface with temporal resolution of seconds to minutes were used in a variety of settings to characterize seepage response to rainfall, wind, and evapotranspiration. Results indicate that instantaneous seepage fluxes can be much larger than values commonly reported in the literature, although seepage does not always respond to hydrological processes. Additional study is needed to understand the reasons for the wide range and types of responses to these hydrologic and atmospheric events.

A Boundary Condition Relaxation Algorithm for Strongly Coupled, Ablating Flows Including Shape Change

NASA Technical Reports Server (NTRS)

Gnoffo, Peter A.; Johnston, Christopher O.

2011-01-01

Implementations of a model for equilibrium, steady-state ablation boundary conditions are tested for the purpose of providing strong coupling with a hypersonic flow solver. The objective is to remove correction factors or film cooling approximations that are usually applied in coupled implementations of the flow solver and the ablation response. Three test cases are considered - the IRV-2, the Galileo probe, and a notional slender, blunted cone launched at 10 km/s from the Earth's surface. A successive substitution is employed and the order of succession is varied as a function of surface temperature to obtain converged solutions. The implementation is tested on a specified trajectory for the IRV-2 to compute shape change under the approximation of steady-state ablation. Issues associated with stability of the shape change algorithm caused by explicit time step limits are also discussed.

Brief Communication: A Simplified Approach to Transient Convective Droplet Evaporation and Burning

NASA Technical Reports Server (NTRS)

Madooglu, K.; Karagozian, A. R.

1994-01-01

Empirical correlations for evaporation rates from single fuel droplets have existed since the 1930s. These correlations, which will be referred to in this article as Froessling/Ranz-Marshall types of correlations, are appropriate to the special cases of steady-state evaporation in the absence of chemical reaction. In a previous article by the authors, the quasi-steady evaporation and burning processes associated with a fuel drop in a convective environment are examined through a droplet model based on the boundary layer approach. For droplet Reynolds numbers of practical interest, this model produces very reasonable steady state as well as quasi-time-dependent droplet simulations, requiring relatively short computational times and yielding good agreement with the above-mentioned empirical correlations. The steady-state case, however, is usually relevant to practical combustor situations only when the drop has reached a nearly uniform temperature since the heating process of the drop cannot be considered to be quasi-steady. In the present study, the transient heating process of the droplet interior during evaporation and/or burning is taken into account, and thus calculations pertaining to the entire life-time of the droplet are carried out. It is of particular interest here to obtain simplified correlations to describe the transient behavior of evaporating and burning droplets; these may be incorporated with greater ease into spray calculations. Accordingly, we have chosen to use stagnation conditions in the present model in a modification of the Froessling/Ranz-Marshall correlations. These modified correlations, incorporating an effective transfer number, produce a fairly accurate representation of droplet evaporation and burning, while requiring only one tenth the computational effort used in a full boundary layer solution.

Collisional evolution - an analytical study for the nonsteady-state mass distribution

NASA Astrophysics Data System (ADS)

Martins, R. Vieira

1999-05-01

To study the collisional evolution of asteroidal groups we can use an analytical solutionfor the self-similar collision cascades. This solution is suitable to study the steady-state massdistribution of the collisional fragmentation. However, out of the steady-state conditions, thissolution is not satisfactory for some values of the collisional parameters. In fact, for some valuesfor the exponent of the mass distribution power law of an asteroidal group and its relation to theexponent of the function which describes how rocks break we arrive at singular points for theequation which describes the collisional evolution. These singularities appear since someapproximations are usually made in the laborious evaluation of many integrals that appear in theanalytical calculations. They concern the cutoff for the smallest and the largest bodies. Thesesingularities set some restrictions to the study of the analytical solution for the collisionalequation. To overcome these singularities we performed an algebraic computationconsidering the smallest and the largest bodies and we obtained the analytical expressions for theintegrals that describe the collisional evolution without restriction on the parameters. However,the new distribution is more sensitive to the values of the collisional parameters. In particular thesteady-state solution for the differential mass distribution has exponents slightly different from11⧸6 for the usual parameters in the Asteroid Belt. The sensitivity of this distribution with respectto the parameters is analyzed for the usual values in the asteroidal groups. With anexpression for the mass distribution without singularities, we can evaluate also its time evolution.We arrive at an analytical expression given by a power series of terms constituted by a smallparameter multiplied by the mass to an exponent, which depends on the initial power lawdistribution. This expression is a formal solution for the equation which describes the collisionalevolution. Furthermore, the first-order term for this solution is the time rate of the distribution atthe initial time. In particular the solution shows the fundamental importance played by theexponent of the power law initial condition in the evolution of the system.

Self-induced transparency of an extremely short pulse

NASA Technical Reports Server (NTRS)

Lee, C. T.

1973-01-01

An extremely short pulse propagation in a resonant medium is properly described by a closed form steady-state analytic solution. The usual slowly varying envelope approximation (SVEA) is not made. Instead, different assumptions with respect to pulse speed and pulse duration are used, and any possible nonresonant loss is ignored. This study indicates that the results obtained by the SVEA approach are much better than they have been intuitively expected to be.

Minimal gain marching schemes: searching for unstable steady-states with unsteady solvers

NASA Astrophysics Data System (ADS)

de S. Teixeira, Renan; S. de B. Alves, Leonardo

2017-12-01

Reference solutions are important in several applications. They are used as base states in linear stability analyses as well as initial conditions and reference states for sponge zones in numerical simulations, just to name a few examples. Their accuracy is also paramount in both fields, leading to more reliable analyses and efficient simulations, respectively. Hence, steady-states usually make the best reference solutions. Unfortunately, standard marching schemes utilized for accurate unsteady simulations almost never reach steady-states of unstable flows. Steady governing equations could be solved instead, by employing Newton-type methods often coupled with continuation techniques. However, such iterative approaches do require large computational resources and very good initial guesses to converge. These difficulties motivated the development of a technique known as selective frequency damping (SFD) (Åkervik et al. in Phys Fluids 18(6):068102, 2006). It adds a source term to the unsteady governing equations that filters out the unstable frequencies, allowing a steady-state to be reached. This approach does not require a good initial condition and works well for self-excited flows, where a single nonzero excitation frequency is selected by either absolute or global instability mechanisms. On the other hand, it seems unable to damp stationary disturbances. Furthermore, flows with a broad unstable frequency spectrum might require the use of multiple filters, which delays convergence significantly. Both scenarios appear in convectively, absolutely or globally unstable flows. An alternative approach is proposed in the present paper. It modifies the coefficients of a marching scheme in such a way that makes the absolute value of its linear gain smaller than one within the required unstable frequency spectra, allowing the respective disturbance amplitudes to decay given enough time. These ideas are applied here to implicit multi-step schemes. A few chosen test cases shows that they enable convergence toward solutions that are unstable to stationary and oscillatory disturbances, with either a single or multiple frequency content. Finally, comparisons with SFD are also performed, showing significant reduction in computer cost for complex flows by using the implicit multi-step MGM schemes.

Instabilities and Chaotic Behavior of Active and Passive Laser Systems.

DTIC Science & Technology

1985-03-01

Some of these attractors, already well-known from elementary calculus, are the steady states of the system, i.e., configurations such that all the time ...charactaristic fundamental frequencies (the reciprocal of the round-trip time around the limit cycle) and usually a host of harmonic components, whose origin is...provided with a hybrid electro-optic device in which the delay of the feed- 2 back loop was made considerably larger than the response time of the system

Pharmacokinetics of isotretinoin during repetitive dosing to patients.

PubMed

Brazzell, R K; Vane, F M; Ehmann, C W; Colburn, W A

1983-01-01

The multiple dose pharmacokinetics of isotretinoin and its major blood metabolite, 4-oxo-isotretinoin, were studied in 10 patients with cystic acne and 11 patients with various keratinization disorders. Blood samples were obtained at predetermined times following the first dose, interim doses and the final dose. Blood concentrations of isotretinoin and 4-oxo-isotretinoin were measured by a specific and sensitive HPLC method. A lag time was usually observed prior to the onset of absorption following oral administration of the drug in a soft elastic gelatin capsule. Absorption then proceeded rapidly and maximum blood concentrations usually occurred within 4 h of drug administration. The harmonic mean half-life for the elimination of isotretinoin by the cystic acne patients was approximately 10 h after the initial dose and did not change significantly following 25 days of 40 mg b.i.d. dosing. Steady-state blood concentrations remained relatively constant after the fifth day of dosing. The harmonic mean elimination half-life in the patients with various disorders of keratinization was about 16 h. The results of the 2 studies suggest that no significant changes in the pharmacokinetics of isotretinoin occur during multiple dosing and that the multiple dose pharmacokinetic profile is predictable and can be described using a linear pharmacokinetic model. This suggests that the steady-state concentrations of isotretinoin can be predicted from single dose data.

Digital hum filtering

USGS Publications Warehouse

Knapp, R.W.; Anderson, N.L.

1994-01-01

Data may be overprinted by a steady-state cyclical noise (hum). Steady-state indicates that the noise is invariant with time; its attributes, frequency, amplitude, and phase, do not change with time. Hum recorded on seismic data usually is powerline noise and associated higher harmonics; leakage from full-waveform rectified cathodic protection devices that contain the odd higher harmonics of powerline frequencies; or vibrational noise from mechanical devices. The fundamental frequency of powerline hum may be removed during data acquisition with the use of notch filters. Unfortunately, notch filters do not discriminate signal and noise, attenuating both. They also distort adjacent frequencies by phase shifting. Finally, they attenuate only the fundamental mode of the powerline noise; higher harmonics and frequencies other than that of powerlines are not removed. Digital notch filters, applied during processing, have many of the same problems as analog filters applied in the field. The method described here removes hum of a particular frequency. Hum attributes are measured by discrete Fourier analysis, and the hum is canceled from the data by subtraction. Errors are slight and the result of the presence of (random) noise in the window or asynchrony of the hum and data sampling. Error is minimized by increasing window size or by resampling to a finer interval. Errors affect the degree of hum attenuation, not the signal. The residual is steady-state hum of the same frequency. ?? 1994.

Jovian vortices by simulated annealing

NASA Astrophysics Data System (ADS)

Morrison, P. J.; Flierl, G. R.; Swaminathan, R. V.

2017-11-01

We explore the conditions required for isolated vortices to exist in sheared zonal flows and the stability of the underlying zonal winds. This is done using the standard 2-layer quasigeostrophic model with the lower layer depth becoming infinite; however, this model differs from the usual layer model because the lower layer is not assumed to be motionless but has a steady configuration of alternating zonal flows. Steady state vortices are obtained by a simulated annealing computational method introduced in, generalized and applied in in fluid flow, and used in the context of magnetohydrodynamics in. Various cases of vortices with a constant potential vorticity anomaly atop zonal winds and the stability of the underlying winds are considered using a mix of computational and analytical techniques. U.S. Department of Energy Contract DE-FG05-80ET-53088.

Comparison of SANS instruments at reactors and pulsed sources

DOE Office of Scientific and Technical Information (OSTI.GOV)

Thiyagarajan, P.; Epperson, J.E.; Crawford, R.K.

1992-09-01

Small angle neutron scattering is a general purpose technique to study long range fluctuations and hence has been applied in almost every field of science for material characterization. SANS instruments can be built at steady state reactors and at the pulsed neutron sources where time-of-flight (TOF) techniques are used. The steady state instruments usually give data over small q ranges and in order to cover a large q range these instruments have to be reconfigured several times and SANS measurements have to be made. These instruments have provided better resolution and higher data rates within their restricted q ranges untilmore » now, but the TOF instruments are now developing to comparable performance. The TOF-SANS instruments, by using a wide band of wavelengths, can cover a wide dynamic q range in a single measurement. This is a big advantage for studying systems that are changing and those which cannot be exactly reproduced. This paper compares the design concepts and performances of these two types of instruments.« less

Human body thermal images generated by conduction or radiation heat

NASA Astrophysics Data System (ADS)

Gavriloaia, Gheorghe; Sofron, Emil; Fumarel, Radu

2009-01-01

Humans and animals in general, are usually in a thermal steady state with respect to their surroundings. The tissues heat, generated at normal or diseases states, is lost to environment though several mechanisms: radiation, conduction, convection, evaporation, etc. Skin temperature is not the same on the entire body and a thermal body signature can be got. The temperature at skin level was measured by a thermistor, conduction component and by an IR camera, radiation component. A theoretical analysis using Weinhaum and JIJI model was done. The three images are investigated in order to get a cheap method for the early cancer diagnosis.

Bifurcation and stability of finite amplitude convection in a rotating layer

NASA Astrophysics Data System (ADS)

Soward, A. M.

1985-01-01

The nature of small amplitude Rayleigh-Bénard convection for a horizontal plane layer of fluid rotating about a vertical axis and heated from below is considered. When the usual approximations are made the evolution of three convective rolls with axes inclined at 60° one to another is described by the coupled non-linear Gause-Lotka-Volterra equations. For sufficiently large rotation rates they have no steady solutions. Instead there is a degenerate time-periodic solution of infinite period in which the phase space trajectory passes successively from one unstable equilibrium point, a single roll, to another (a heteroclinic orbit). In this paper additional terms, which correspond to vertical asymmetries in the physical system, are included and as a result the degeneracy is removed. The steady state and time-periodic solutions are derived and their stability discussed.

Operational Characteristics of an Accelerator Driven Fissile Solution System

DOE Office of Scientific and Technical Information (OSTI.GOV)

Kimpland, Robert Herbert

Operational characteristics represent the set of responses that a nuclear system exhibits during normal operation. Operators rely on this behavior to assess the status of the system and to predict the consequences of off-normal events. These characteristics largely refer to the relationship between power and system operating conditions. The static and dynamic behavior of a chain-reacting system, operating at sufficient power, is primarily governed by reactivity effects. The science of reactor physics has identified and evaluated a number of such effects, including Doppler broadening and shifts in the thermal neutron spectrum. Often these reactivity effects are quantified in the formmore » of feedback coefficients that serve as coupling coefficients relating the neutron population and the physical mechanisms that drive reactivity effects, such as fissile material temperature and density changes. The operational characteristics of such nuclear systems usually manifest themselves when perturbations between system power (neutron population) and system operating conditions arise. Successful operation of such systems requires the establishment of steady equilibrium conditions. However, prior to obtaining the desired equilibrium (steady-state) conditions, an approach from zero-power (startup) must occur. This operational regime may possess certain limiting system conditions that must be maintained to achieve effective startup. Once steady-state is achieved, a key characteristic of this operational regime is the level of stability that the system possesses. Finally, a third operational regime, shutdown, may also possess limiting conditions of operation that must be maintained. This report documents the operational characteristics of a “generic” Accelerator Driven Fissile Solution (ADFS) system during the various operational regimes of startup, steady-state operation, and shutdown. Typical time-dependent behavior for each operational regime will be illustrated, and key system parameters, such as response times, will be quantified. A generalized linear systems analysis of steady-state operations will be performed to evaluate the level of stability of ADFS systems. This information should provide a basic understanding of typical ADFS system operational behavior, and facilitate the development of monitoring procedures and operator aids.« less

Intrinsic diffusion sensitivity of the balanced steady-state free precession (bSSFP) imaging sequence.

PubMed

Bär, Sébastien; Weigel, Matthias; von Elverfeldt, Dominik; Hennig, Jürgen; Leupold, Jochen

2015-11-01

The purpose of this work was to analyze the intrinsic diffusion sensitivity of the balanced steady-state free precession (bSSFP) imaging sequence, meaning the observation of diffusion-induced attenuation of the bSSFP steady-state signal due to the imaging gradients. Although these diffusion effects are usually neglected for most clinical gradient systems, such strong gradient systems are employed for high resolution imaging of small animals or MR Microscopy. The impact on the bSSFP signal of the imaging gradients characterized by their b-values was analyzed with simulations and experiments at a 7T animal scanner using a gradient system with maximum gradient amplitude of approx. 700 mT/m. It was found that the readout gradients have a stronger impact on the attenuation than the phase encoding gradients. Also, as the PE gradients are varying with each repetition interval, the diffusion effects induce strong modulations of the bSSFP signal over the sequence repetition cycles depending on the phase encoding gradient table. It is shown that a signal gain can be obtained through a change of flip angle as a new optimal flip angle maximizing the signal can be defined. The dependency of the diffusion effects on relaxation times and b-values were explored with simulations. The attenuation increases with T2. In conclusion, diffusion attenuation of the bSSFP signal becomes significant for high resolution imaging voxel size (roughly < 100 μm) of long T2 substances. Copyright © 2015 John Wiley & Sons, Ltd.

Dynamic Modeling of ALS Systems

NASA Technical Reports Server (NTRS)

Jones, Harry

2002-01-01

The purpose of dynamic modeling and simulation of Advanced Life Support (ALS) systems is to help design them. Static steady state systems analysis provides basic information and is necessary to guide dynamic modeling, but static analysis is not sufficient to design and compare systems. ALS systems must respond to external input variations and internal off-nominal behavior. Buffer sizing, resupply scheduling, failure response, and control system design are aspects of dynamic system design. We develop two dynamic mass flow models and use them in simulations to evaluate systems issues, optimize designs, and make system design trades. One model is of nitrogen leakage in the space station, the other is of a waste processor failure in a regenerative life support system. Most systems analyses are concerned with optimizing the cost/benefit of a system at its nominal steady-state operating point. ALS analysis must go beyond the static steady state to include dynamic system design. All life support systems exhibit behavior that varies over time. ALS systems must respond to equipment operating cycles, repair schedules, and occasional off-nominal behavior or malfunctions. Biological components, such as bioreactors, composters, and food plant growth chambers, usually have operating cycles or other complex time behavior. Buffer sizes, material stocks, and resupply rates determine dynamic system behavior and directly affect system mass and cost. Dynamic simulation is needed to avoid the extremes of costly over-design of buffers and material reserves or system failure due to insufficient buffers and lack of stored material.

Mimicking Nonequilibrium Steady States with Time-Periodic Driving

DTIC Science & Technology

2016-08-29

nonequilibrium steady states, and vice versa, within the theoretical framework of discrete-state stochastic thermodynamics . Nonequilibrium steady states...equilibrium [2], spontaneous relaxation towards equilibrium [3], nonequilibrium steady states generated by fixed thermodynamic forces [4], and stochastic pumps...paradigm, a system driven by fixed thermodynamic forces—such as temperature gradients or chemical potential differences— reaches a steady state in

Mimicking Nonequilibrium Steady States with Time-Periodic Driving (Open Source)

DTIC Science & Technology

2016-05-18

nonequilibrium steady states, and vice versa, within the theoretical framework of discrete-state stochastic thermodynamics . Nonequilibrium steady states...equilibrium [2], spontaneous relaxation towards equilibrium [3], nonequilibrium steady states generated by fixed thermodynamic forces [4], and stochastic pumps...paradigm, a system driven by fixed thermodynamic forces—such as temperature gradients or chemical potential differences— reaches a steady state in

Post-processing of auditory steady-state responses to correct spectral leakage.

PubMed

Felix, Leonardo Bonato; de Sá, Antonio Mauricio Ferreira Leite Miranda; Mendes, Eduardo Mazoni Andrade Marçal; Moraes, Márcio Flávio Dutra

2009-06-30

Auditory steady-state responses (ASSRs) are electrical manifestations of brain due to high rate sound stimulation. These evoked responses can be used to assess the hearing capabilities of a subject in an objective, automatic fashion. Usually, the detection protocol is accomplished by frequency-domain techniques, such as magnitude-squared coherence, whose estimation is based on the fast Fourier transform (FFT) of several data segments. In practice, the FFT-based spectrum may spread out the energy of a given frequency to its side bins and this escape of energy in the spectrum is called spectral leakage. The distortion of the spectrum due to leakage may severely compromise statistical significance of objective detection. This work presents an offline, a posteriori method for spectral leakage minimization in the frequency-domain analysis of ASSRs using coherent sampling criterion and interpolation in time. The technique was applied to the local field potentials of 10 Wistar rats and the results, together with those from simulated data, indicate that a leakage-free analysis of ASSRs is possible for any dataset if the methods showed in this paper were followed.

Measuring the steady-state properties of Ca²⁺ indicators with a set of calibrated [Ca²⁺] solutions.

PubMed

Faas, Guido C; Mody, Istvan

2014-07-01

Fluorescent Ca(2+) indicators are widely used to measure the concentration of free Ca(2+) ([Ca(2+)]free) in biological processes. By calibrating the dye under the same experimental conditions as employed during its planned use, the actual [Ca(2+)] can be calculated from the measured fluorescence. When using non ratiometric dyes, such as the Oregon Green BAPTA (OGB) family of dyes or the Fluo dyes, the steady-state affinity (K(d)) and the ratio between the maximal and minimal fluorescence (F(ratio) = F(max)/F(min)) of the particular dye are needed for this conversion. Although these values are usually given by the manufacturer, we consistently find that the actual values can differ between various batches delivered by the companies that make the dyes. In this protocol, we provide the recipe for a series of solutions with a known and tightly buffered [Ca(2+)](free) and describe how to use these mixtures to determine the exact K(d) and F(ratio) of a fluorescent Ca(2+) dye. © 2014 Cold Spring Harbor Laboratory Press.

Modelling transient temperature distribution for injecting hot water through a well to an aquifer thermal energy storage system

NASA Astrophysics Data System (ADS)

Yang, Shaw-Yang; Yeh, Hund-Der; Li, Kuang-Yi

2010-10-01

Heat storage systems are usually used to store waste heat and solar energy. In this study, a mathematical model is developed to predict both the steady-state and transient temperature distributions of an aquifer thermal energy storage (ATES) system after hot water is injected through a well into a confined aquifer. The ATES has a confined aquifer bounded by aquicludes with different thermomechanical properties and geothermal gradients along the depth. Consider that the heat is transferred by conduction and forced convection within the aquifer and by conduction within the aquicludes. The dimensionless semi-analytical solutions of temperature distributions of the ATES system are developed using Laplace and Fourier transforms and their corresponding time-domain results are evaluated numerically by the modified Crump method. The steady-state solution is obtained from the transient solution through the final-value theorem. The effect of the heat transfer coefficient on aquiclude temperature distribution is appreciable only near the outer boundaries of the aquicludes. The present solutions are useful for estimating the temperature distribution of heat injection and the aquifer thermal capacity of ATES systems.

Gaining insights into the consequences of target-mediated drug disposition of monoclonal antibodies using quasi-steady-state approximations.

PubMed

Grimm, Hans Peter

2009-10-01

Target-mediated drug disposition (TMDD) is frequently reported for therapeutic monoclonal antibodies and is linked to the high affinity and high specificity of antibody molecules for their target. Understanding TMDD of a monoclonal antibody should go beyond the empirical description of its non-linear PK since valuable insights on the antibody-target interaction itself can be gained. This makes its mechanistic understanding precious for the drug development process, in particular for the optimization of new antibody molecules, for the design and interpretation of pharmacokinetic studies, and possibly even for the evaluation of efficacy and dose selection of drug candidates. Using the observation that the molecular (microscopic) processes are usually much more rapid than the pharmacokinetic (macroscopic) processes, a series of quasi-steady-state conditions on the microscopic level is proposed to bridge the gap between simple empirical and complex mechanistic descriptions of TMDD. These considerations show the impact of parameters such as target turnover, target expression, and target accessibility on the pharmacokinetics and pharmacodynamics of monoclonal antibodies.

Mechanism-based modeling of solute strengthening: application to thermal creep in Zr alloy

DOE Office of Scientific and Technical Information (OSTI.GOV)

Tome, Carlos; Wen, Wei; Capolungo, Laurent

2017-08-01

This report focuses on the development of a physics-based thermal creep model aiming to predict the behavior of Zr alloy under reactor accident condition. The current models used for this kind of simulations are mostly empirical in nature, based generally on fits to the experimental steady-state creep rates under different temperature and stress conditions, which has the following limitations. First, reactor accident conditions, such as RIA and LOCA, usually take place in short times and involve only the primary, not the steady-state creep behavior stage. Moreover, the empirical models cannot cover the conditions from normal operation to accident environments. Formore » example, Kombaiah and Murty [1,2] recently reported a transition between the low (n~4) and high (n~9) power law creep regimes in Zr alloys depending on the applied stress. Capturing such a behavior requires an accurate description of the mechanisms involved in the process. Therefore, a mechanism-based model that accounts for the evolution with time of microstructure is more appropriate and reliable for this kind of simulation.« less

Oligopolies with contingent workforce and unemployment insurance systems

NASA Astrophysics Data System (ADS)

Matsumoto, Akio; Merlone, Ugo; Szidarovszky, Ferenc

2015-10-01

In the recent literature the introduction of modified cost functions has added reality into the classical oligopoly analysis. Furthermore, the market evolution requires much more flexibility to firms, and in several countries contingent workforce plays an important role in the production choices by the firms. Therefore, an analysis of dynamic adjustment costs is in order to understand oligopoly dynamics. In this paper, dynamic single-product oligopolies without product differentiation are first examined with the additional consideration of production adjustment costs. Linear inverse demand and cost functions are considered and it is assumed that the firms adjust their outputs partially toward best response. The set of the steady states is characterized by a system of linear inequalities and there are usually infinitely many steady states. The asymptotic behavior of the output trajectories is examined by using computer simulation. The numerical results indicate that the resulting dynamics is richer than in the case of the classical Cournot model. This model and results are then compared to oligopolies with unemployment insurance systems when the additional cost is considered if firms do not use their maximum capacities.

Heat conduction in cooling flows. [in clusters of galaxies

NASA Technical Reports Server (NTRS)

Bregman, Joel N.; David, L. P.

1988-01-01

It has been suggested that electron conduction may significantly reduce the accretion rate (and star foramtion rate) for cooling flows in clusters of galaxies. A numerical hydrodynamics code was used to investigate the time behavior of cooling flows with conduction. The usual conduction coefficient is modified by an efficiency factor, mu, to realize the effects of tangled magnetic field lines. Two classes of models are considered, one where mu is independent of position and time, and one where inflow stretches the field lines and changes mu. In both cases, there is only a narrow range of initial conditions for mu in which the cluster accretion rate is reduced while a significant temperature gradient occurs. In the first case, no steady solution exists in which both conditions are met. In the second case, steady state solutions occur in which both conditions are met, but only for a narrow range of initial values where mu = 0.001.

Pseudo Steady-State Free Precession for MR-Fingerprinting.

PubMed

Assländer, Jakob; Glaser, Steffen J; Hennig, Jürgen

2017-03-01

This article discusses the signal behavior in the case the flip angle in steady-state free precession sequences is continuously varied as suggested for MR-fingerprinting sequences. Flip angle variations prevent the establishment of a steady state and introduce instabilities regarding to magnetic field inhomogeneities and intravoxel dephasing. We show how a pseudo steady state can be achieved, which restores the spin echo nature of steady-state free precession. Based on geometrical considerations, relationships between the flip angle, repetition and echo time are derived that suffice to the establishment of a pseudo steady state. The theory is tested with Bloch simulations as well as phantom and in vivo experiments. A typical steady-state free precession passband can be restored with the proposed conditions. The stability of the pseudo steady state is demonstrated by comparing the evolution of the signal of a single isochromat to one resulting from a spin ensemble. As confirmed by experiments, magnetization in a pseudo steady state can be described with fewer degrees of freedom compared to the original fingerprinting and the pseudo steady state results in more reliable parameter maps. The proposed conditions restore the spin-echo-like signal behavior typical for steady-state free precession in fingerprinting sequences, making this approach more robust to B 0 variations. Magn Reson Med 77:1151-1161, 2017. © 2016 International Society for Magnetic Resonance in Medicine. © 2016 International Society for Magnetic Resonance in Medicine.

Mechanism for multiplicity of steady states with distinct cell concentration in continuous culture of mammalian cells.

PubMed

Yongky, Andrew; Lee, Jongchan; Le, Tung; Mulukutla, Bhanu Chandra; Daoutidis, Prodromos; Hu, Wei-Shou

2015-07-01

Continuous culture for the production of biopharmaceutical proteins offers the possibility of steady state operations and thus more consistent product quality and increased productivity. Under some conditions, multiplicity of steady states has been observed in continuous cultures of mammalian cells, wherein with the same dilution rate and feed nutrient composition, steady states with very different cell and product concentrations may be reached. At those different steady states, cells may exhibit a high glycolysis flux with high lactate production and low cell concentration, or a low glycolysis flux with low lactate and high cell concentration. These different steady states, with different cell concentration, also have different productivity. Developing a mechanistic understanding of the occurrence of steady state multiplicity and devising a strategy to steer the culture toward the desired steady state is critical. We establish a multi-scale kinetic model that integrates a mechanistic intracellular metabolic model and cell growth model in a continuous bioreactor. We show that steady state multiplicity exists in a range of dilution rate in continuous culture as a result of the bistable behavior in glycolysis. The insights from the model were used to devise strategies to guide the culture to the desired steady state in the multiple steady state region. The model provides a guideline principle in the design of continuous culture processes of mammalian cells. © 2015 Wiley Periodicals, Inc.

On the precision of quasi steady state assumptions in stochastic dynamics

NASA Astrophysics Data System (ADS)

Agarwal, Animesh; Adams, Rhys; Castellani, Gastone C.; Shouval, Harel Z.

2012-07-01

Many biochemical networks have complex multidimensional dynamics and there is a long history of methods that have been used for dimensionality reduction for such reaction networks. Usually a deterministic mass action approach is used; however, in small volumes, there are significant fluctuations from the mean which the mass action approach cannot capture. In such cases stochastic simulation methods should be used. In this paper, we evaluate the applicability of one such dimensionality reduction method, the quasi-steady state approximation (QSSA) [L. Menten and M. Michaelis, "Die kinetik der invertinwirkung," Biochem. Z 49, 333369 (1913)] for dimensionality reduction in case of stochastic dynamics. First, the applicability of QSSA approach is evaluated for a canonical system of enzyme reactions. Application of QSSA to such a reaction system in a deterministic setting leads to Michaelis-Menten reduced kinetics which can be used to derive the equilibrium concentrations of the reaction species. In the case of stochastic simulations, however, the steady state is characterized by fluctuations around the mean equilibrium concentration. Our analysis shows that a QSSA based approach for dimensionality reduction captures well the mean of the distribution as obtained from a full dimensional simulation but fails to accurately capture the distribution around that mean. Moreover, the QSSA approximation is not unique. We have then extended the analysis to a simple bistable biochemical network model proposed to account for the stability of synaptic efficacies; the substrate of learning and memory [J. E. Lisman, "A mechanism of memory storage insensitive to molecular turnover: A bistable autophosphorylating kinase," Proc. Natl. Acad. Sci. U.S.A. 82, 3055-3057 (1985)], 10.1073/pnas.82.9.3055. Our analysis shows that a QSSA based dimensionality reduction method results in errors as big as two orders of magnitude in predicting the residence times in the two stable states.

Quasi-steady state conditions in heterogeneous aquifers during pumping tests

NASA Astrophysics Data System (ADS)

Zha, Yuanyuan; Yeh, Tian-Chyi J.; Shi, Liangsheng; Huang, Shao-Yang; Wang, Wenke; Wen, Jet-Chau

2017-08-01

Classical Thiem's well hydraulic theory, other aquifer test analyses, and flow modeling efforts often assume the existence of ;quasi-steady; state conditions. That is, while drawdowns due to pumping continue to grow, the hydraulic gradient in the vicinity of the pumping well does not change significantly. These conditions have built upon two-dimensional and equivalent homogeneous conceptual models, but few field data have been available to affirm the existence of these conditions. Moreover, effects of heterogeneity and three-dimensional flow on this quasi-steady state concept have not been thoroughly investigated and discussed before. In this study, we first present a quantitative definition of quasi-steady state (or steady-shape conditions) and steady state conditions based on the analytical solution of two- or three-dimensional flow induced by pumping in unbounded, homogeneous aquifers. Afterward, we use a stochastic analysis to investigate the influence of heterogeneity on the quasi-steady state concept in heterogeneous aquifers. The results of the analysis indicate that the time to reach an approximate quasi-steady state in a heterogeneous aquifer could be quite different from that estimated based on a homogeneous model. We find that heterogeneity of aquifer properties, especially hydraulic conductivity, impedes the development of the quasi-steady state condition before the flow reaching steady state. Finally, 280 drawdown-time data from the hydraulic tomographic survey conducted at a field site corroborate our finding that the quasi-steady state condition likely would not take place in heterogeneous aquifers unless pumping tests last a long period. Research significance (1) Approximate quasi-steady and steady state conditions are defined for two- or three-dimensional flow induced by pumping in unbounded, equivalent homogeneous aquifers. (2) Analysis demonstrates effects of boundary condition, well screen interval, and heterogeneity of parameters on the existence of the quasi-steady, and validity of approximate quasi-steady concept. (3) Temporal evaluation of information content about heterogeneity in head observations are analyzed in heterogeneous aquifer. (4) 280 observed drawdown-time data corroborate the stochastic analysis that quasi-steady is difficult to reach in highly heterogeneous aquifers.

Estimating systemic exposure to levonorgestrel from an oral contraceptive.

PubMed

Basaraba, Cale N; Westhoff, Carolyn L; Pike, Malcolm C; Nandakumar, Renu; Cremers, Serge

2017-04-01

The gold standard for measuring oral contraceptive (OC) pharmacokinetics is the 24-h steady-state area under the curve (AUC). We conducted this study to assess whether limited sampling at steady state or measurements following use of one or two OCs could provide an adequate proxy in epidemiological studies for the progestin 24-h steady-state AUC of a particular OC. We conducted a 13-sample, 24-h pharmacokinetic study on both day 1 and day 21 of the first cycle of a monophasic OC containing 30-mcg ethinyl estradiol and 150-mcg levonorgestrel (LNG) in 17 normal-weight healthy White women and a single-dose 9-sample study of the same OC after a 1-month washout. We compared the 13-sample steady-state results with several steady-state and single-dose results calculated using parsimonious sampling schemes. The 13-sample steady-state 24-h LNG AUC was highly correlated with the steady-state 24-h trough value [r=0.95; 95% confidence interval (0.85, 0.98)] and with the steady-state 6-, 8-, 12- and 16-h values (0.92≤r≤0.95). The trough values after one or two doses were moderately correlated with the steady-state 24-h AUC value [r=0.70; 95% CI (0.27, 0.90) and 0.77; 95% CI (0.40, 0.92), respectively]. Single time-point concentrations at steady state and after administration of one or two OCs gave highly to moderately correlated estimates of steady-state LNG AUC. Using such measures could facilitate prospective pharmaco-epidemiologic studies of the OC and its side effects. A single time-point LNG concentration at steady state is an excellent proxy for complete and resource-intensive steady-state AUC measurement. The trough level after two single doses is a fair proxy for steady-state AUC. These results provide practical tools to facilitate large studies to investigate the relationship between systemic LNG exposure and side effects in a real-life setting. Copyright © 2017 Elsevier Inc. All rights reserved.

Enhancing emotional-based target prediction

NASA Astrophysics Data System (ADS)

Gosnell, Michael; Woodley, Robert

2008-04-01

This work extends existing agent-based target movement prediction to include key ideas of behavioral inertia, steady states, and catastrophic change from existing psychological, sociological, and mathematical work. Existing target prediction work inherently assumes a single steady state for target behavior, and attempts to classify behavior based on a single emotional state set. The enhanced, emotional-based target prediction maintains up to three distinct steady states, or typical behaviors, based on a target's operating conditions and observed behaviors. Each steady state has an associated behavioral inertia, similar to the standard deviation of behaviors within that state. The enhanced prediction framework also allows steady state transitions through catastrophic change and individual steady states could be used in an offline analysis with additional modeling efforts to better predict anticipated target reactions.

Steady- and non-steady-state carbonate-silicate controls on atmospheric CO2

USGS Publications Warehouse

Sundquist, E.T.

1991-01-01

Two contrasting hypotheses have recently been proposed for the past long-term relation between atmospheric CO2 and the carbonate-silicate geochemical cycle. One approach (Berner, 1990) suggests that CO2 levels have varied in a manner that has maintained chemical weathering and carbonate sedimentation at a steady state with respect to tectonically controlled decarbonation reactions. A second approach (Raymo et al., 1988), applied specificlly to the late Cenozoic, suggests a decrease in CO2 caused by an uplift-induced increase in chemical weathering, without regard to the rate of decarbonation. According to the steady-state (first) hypothesis, increased weathering and carbonate sedimentation are generally associated with increasing atmospheric CO2, whereas the uplift (second) hypothesis implies decreasing CO2 under the same conditions. An ocean-atmosphere-sediment model has been used to assess the response of atmospheric CO2 and carbonate sedimentation to global perturbations in chemical weathering and decarbonation reactions. Although this assessment is theoretical and cannot yet be related to the geologic record, the model simulations compare steady-state and non-steady-state carbonate-silicate cycle response. The e-fold response time of the 'CO2-weathering' feedback mechanism is between 300 and 400 ka. The response of carbonate sedimentation is much more rapid. These response times provide a measure of the strength of steady-state assumptions, and imply that certain systematic relations are sustained throughout steady-state and non-steady-state scenarios for the carbonate-silicate cycle. The simulations suggest that feedbacks can maintain the system near a steady state, but that non-steady-state effects may contribute to long-term trends. The steady-state and uplift hypotheses are not necessarily incompatible over time scales of a few million years. ?? 1991.

Candle flames in microgravity

NASA Technical Reports Server (NTRS)

Dietrich, D. L.; Ross, H. D.; Tien, J. S.

1995-01-01

The candle flame in both normal and microgravity is non-propagating. In microgravity, however, the candle flame is also non-convective where (excepting Stefan flow) pure diffusion is the only transport mode. It also shares many characteristics with another classical problem, that of isolated droplet combustion. Given their qualitatively similar flame shapes and the required heat feedback to condensed-phase fuels, the gas-phase flow and temperature fields should be relatively similar for a droplet and a candle in reduced gravity. Unless the droplet diameter is maintained somehow through non-intrusive replenishment of fuel, the quasi-steady burning characteristics of a droplet can be maintained for only a few seconds. In contrast, the candle flame in microgravity may achieve a nearly steady state over a much longer time and is therefore ideal for examining a number of combustion-related phenomena. In this paper, we examine candle flame behavior in both short-duration and long-duration, quiescent, microgravity environments. Interest in this type of flame, especially 'candle flames in weightlessness', is demonstrated by very frequent public inquiries. The question is usually posed as 'will a candle flame burn in zero gravity', or, 'will a candle burn indefinitely (or steadily) in zero gravity in a large volume of quiescent air'. Intuitive speculation suggests to some that, in the absence of buoyancy, the accumulation of products in the vicinity of the flame will cause flame extinction. The classical theory for droplet combustion with its spherically-shaped diffusion flame, however, shows that steady combustion is possible in the absence of buoyancy if the chemical kinetics are fast enough. Previous experimental studies of candle flames in reduced and microgravity environments showed the flame could survive for at least 5 seconds, but did not reach a steady state in the available test time.

Steady States, Fluctuation-Dissipation Theorems and Homogenization for Reversible Diffusions in a Random Environment

NASA Astrophysics Data System (ADS)

Mathieu, P.; Piatnitski, A.

2018-04-01

Prolongating our previous paper on the Einstein relation, we study the motion of a particle diffusing in a random reversible environment when subject to a small external forcing. In order to describe the long time behavior of the particle, we introduce the notions of steady state and weak steady state. We establish the continuity of weak steady states for an ergodic and uniformly elliptic environment. When the environment has finite range of dependence, we prove the existence of the steady state and weak steady state and compute its derivative at a vanishing force. Thus we obtain a complete `fluctuation-dissipation Theorem' in this context as well as the continuity of the effective variance.

Steady state volcanism - Evidence from eruption histories of polygenetic volcanoes

NASA Technical Reports Server (NTRS)

Wadge, G.

1982-01-01

Cumulative volcano volume curves are presented as evidence for steady-state behavior at certain volcanoes and to develop a model of steady-state volcanism. A minimum criteria of five eruptions over a year was chosen to characterize a steady-state volcano. The subsequent model features a constant head of magmatic pressure from a reservoir supplied from depth, a sawtooth curve produced by the magma arrivals or discharge from the subvolcanic reservoir, large volume eruptions with long repose periods, and conditions of nonsupply of magma. The behavior of Mts. Etna, Nyamuragira, and Kilauea are described and show continuous levels of plasma output resulting in cumulative volume increases. Further discussion is made of steady-state andesitic and dacitic volcanism, long term patterns of the steady state, and magma storage, and the lack of a sufficient number of steady-state volcanoes in the world is taken as evidence that further data is required for a comprehensive model.

Unifying three perspectives on information processing in stochastic thermodynamics.

PubMed

Barato, A C; Seifert, U

2014-03-07

So far, feedback-driven systems have been discussed using (i) measurement and control, (ii) a tape interacting with a system, or (iii) by identifying an implicit Maxwell demon in steady-state transport. We derive the corresponding second laws from one master fluctuation theorem and discuss their relationship. In particular, we show that both the entropy production involving mutual information between system and controller and the one involving a Shannon entropy difference of an information reservoir like a tape carry an extra term different from the usual current times affinity. We, thus, generalize stochastic thermodynamics to the presence of an information reservoir.

Estimating Systemic Exposure to Levonorgestrel from an Oral Contraceptive

PubMed Central

Basaraba, Cale N; Westhoff, Carolyn L; Pike, Malcolm C; Nandakumar, Renu; Cremers, Serge

2017-01-01

Objective The gold standard for measuring oral contraceptive (OC) pharmacokinetics is the 24-hour steady-state area-under-the-curve (AUC). We conducted this study to assess whether limited sampling at steady state or measurements following use of one or two OCs could provide an adequate proxy in epidemiological studies for the progestin 24-hour steady-state AUC of a particular OC. Study Design We conducted a 13-sample, 24-hour pharmacokinetic study on both day 1 and day 21 of the first cycle of a monophasic OC containing 30 μg ethinyl estradiol and 150 μg levonorgestrel (LNG) in 17 normal-weight healthy white women, and a single-dose 9-sample study of the same OC after a one-month washout. We compared the 13-sample steady-state results with several steady-state and single-dose results calculated using parsimonious sampling schemes. Results The 13-sample steady-state 24-hour LNG AUC was highly correlated with the steady-state 24-hour trough value (r = 0.95; 95% CI [0.85, 0.98]) and with the steady-state 6, 8, 12 and 16-hour values (0.92 ≤ r ≤ 0.95). The trough values after one or two doses were moderately correlated with the steady-state 24-hour AUC value (r = 0.70; 95% CI [0.27, 0.90] and 0.77; 95% CI [0.40, 0.92], respectively). Conclusions Single time-point concentrations at steady-state and after administration of one or two OCs gave highly to moderately correlated estimates of steady-state LNG AUC. Using such measures could facilitate prospective pharmaco-epidemiologic studies of the OC and its side effects. PMID:28041990

Modeling eutrophic lakes: From mass balance laws to ordinary differential equations

NASA Astrophysics Data System (ADS)

Marasco, Addolorata; Ferrara, Luciano; Romano, Antonio

Starting from integral balance laws, a model based on nonlinear ordinary differential equations (ODEs) describing the evolution of Phosphorus cycle in a lake is proposed. After showing that the usual homogeneous model is not compatible with the mixture theory, we prove that an ODEs model still holds but for the mean values of the state variables provided that the nonhomogeneous involved fields satisfy suitable conditions. In this model the trophic state of a lake is described by the mean densities of Phosphorus in water and sediments, and phytoplankton biomass. All the quantities appearing in the model can be experimentally evaluated. To propose restoration programs, the evolution of these state variables toward stable steady state conditions is analyzed. Moreover, the local stability analysis is performed with respect to all the model parameters. Some numerical simulations and a real application to lake Varese conclude the paper.

Multimode optical fibers: steady state mode exciter.

PubMed

Ikeda, M; Sugimura, A; Ikegami, T

1976-09-01

The steady state mode power distribution of the multimode graded index fiber was measured. A simple and effective steady state mode exciter was fabricated by an etching technique. Its insertion loss was 0.5 dB for an injection laser. Deviation in transmission characteristics of multimode graded index fibers can be avoided by using the steady state mode exciter.

A kinetic approach to the study of absorption of solutes by isolated perfused small intestine

PubMed Central

Fisher, R. B.; Gardner, M. L. G.

1974-01-01

1. A new technique has been developed for making serial measurements of water and solute absorption from the lumen of isolated small intestine. 2. The isolated intestine is perfused in a single pass with a segmented flow of slugs of liquid separated by bubbles of oxygen-carbon dioxide mixture. Simultaneous collections are made of effluent from the lumen and of the fluid which is transported across the mucosa. This latter fluid appears to be a fair sample of the tissue fluid. 3. Conditions in the lumen can be changed within less than 5 min. The effects of two or more treatments applied to the same segment of intestine can be determined and the time course of a change in luminal conditions. 4. The rate of appearance of solutes on the serosal side depends on the rate of water absorption, and changes exponentially towards a steady state. The rate constant is a function of tissue fluid volume. 5. In the steady state the concentration of glucose in the tissue fluid is 71 mM when the luminal concentration is 28 mM, and is 45 mM when the luminal concentration is 8·3 mM. 6. For solutes such as glucose for which reflux from tissue fluid to lumen is small relative to flux from lumen to tissue fluid, the time of attainment of a steady state in secretion is usually 50-60 min. 7. For solutes such as sodium for which the reflux is relatively high, the steady state may be reached in 15-20 min. 8. The Km for glucose absorption (14-19 mM) is much lower than is found with unsegmented flow perfusion. 9. These findings emphasize problems in interpreting results from other types of intestinal preparation. 10. The rate of glucose absorption from the lumen falls only gradually when the luminal sodium concentration is reduced abruptly. In contrast the rate of glucose absorption falls suddenly when the luminal glucose concentration is reduced abruptly. This suggests that glucose absorption is not directly dependent on luminal sodium ions. ImagesPlate 1 PMID:4422346

A Study of the Effect of Surfactants on the Aggregation Behavior of Crude Oil Aqueous Dispersions through Steady-State Fluorescence Spectrometry.

PubMed

Vallejo-Cardona, Alba A; Cerón-Camacho, Ricardo; Karamath, James R; Martínez-Palou, Rafael; Aburto, Jorge

2017-07-01

Unconventional crude oil as heavy, extra heavy, bitumen, tight, and shale oils will meet 10% of worldwide needs for 2035, perhaps earlier. Petroleum companies will face problems concerning crude oil extraction, production, transport, and refining, and some of these are addressed by the use of surfactants and other chemicals. For example, water-in-crude oil emulsions are frequently found during the production of mature wells where enhanced recovery techniques have been deployed. Nevertheless, the selection of adequate surfactant, dosage, type of water (sea, tap or oilfield), kind of crude oil (light, heavy, extra heavy, tight, shale, bitumen) affect the effectivity of treatment and usual bottle tests give limited information. We developed a fluorescence technique to study the effect of surfactants on medium, heavy, and extra heavy crude oil employing the natural fluorophore molecules from petroleum. We first carried out the characterization of commercial and synthetic surfactants, then dispersions of petroleum in water were studied by steady-state fluorometry and the size of petroleum aggregates were measured. The aggregation of petroleum incremented from medium to extra heavy crude oil and we discussed the effect of different surfactants on such aggregation.

Bounds on stochastic chemical kinetic systems at steady state

NASA Astrophysics Data System (ADS)

Dowdy, Garrett R.; Barton, Paul I.

2018-02-01

The method of moments has been proposed as a potential means to reduce the dimensionality of the chemical master equation (CME) appearing in stochastic chemical kinetics. However, attempts to apply the method of moments to the CME usually result in the so-called closure problem. Several authors have proposed moment closure schemes, which allow them to obtain approximations of quantities of interest, such as the mean molecular count for each species. However, these approximations have the dissatisfying feature that they come with no error bounds. This paper presents a fundamentally different approach to the closure problem in stochastic chemical kinetics. Instead of making an approximation to compute a single number for the quantity of interest, we calculate mathematically rigorous bounds on this quantity by solving semidefinite programs. These bounds provide a check on the validity of the moment closure approximations and are in some cases so tight that they effectively provide the desired quantity. In this paper, the bounded quantities of interest are the mean molecular count for each species, the variance in this count, and the probability that the count lies in an arbitrary interval. At present, we consider only steady-state probability distributions, intending to discuss the dynamic problem in a future publication.

A comparison of methods for determining HIV viral set point.

PubMed

Mei, Y; Wang, L; Holte, S E

2008-01-15

During a course of human immunodeficiency virus (HIV-1) infection, the viral load usually increases sharply to a peak following infection and then drops rapidly to a steady state, where it remains until progression to AIDS. This steady state is often referred to as the viral set point. It is believed that the HIV viral set point results from an equilibrium between the HIV virus and immune response and is an important indicator of AIDS disease progression. In this paper, we analyze a real data set of viral loads measured before antiretroviral therapy is initiated, and propose two-phase regression models to utilize all available data to estimate the viral set point. The advantages of the proposed methods are illustrated by comparing them with two empirical methods, and the reason behind the improvement is also studied. Our results illustrate that for our data set, the viral load data are highly correlated and it is cost effective to estimate the viral set point based on one or two measurements obtained between 5 and 12 months after HIV infection. The utility and limitations of this recommendation will be discussed. Copyright (c) 2007 John Wiley & Sons, Ltd.

Son of IXION: A Steady State Centrifugally Confined Plasma for Fusion*

NASA Astrophysics Data System (ADS)

Hassam, Adil

1996-11-01

A magnetic confinement scheme in which the inertial, u.grad(u), forces effect parallel confinement is proposed. The basic geometry is mirror-like as far as the poloidal field goes or, more simply, multipole (FM-1) type. The rotation is toroidal in this geometry. A supersonic rotation can effect complete parallel confinement, with the usual magnetic mirror force rendered irrelevant. The rotation shear, in addition, aids in the suppression of the flute mode. This suppression is not complete which indicates the addition of a toroidal field, at maximum of the order of the poloidal field. We show that at rotation in excess of Mach 3, the parallel particle and heat losses can be minimized to below the Lawson breakeven point. The crossfield transport can be expected to be better than tokamaks on account of the large velocity shear. Other advantages of the scheme are that it is steady state and disruption free. An exploratory experiment that tests equilibrium, parallel detachment, and MHD stability is proposed. The concept resembles earlier (Geneva, 1958) experiments on "homopolar generators" and a mirror configuration called IXION. Ixion, Greek mythological king, was forever strapped to a rotating, flaming wheel. *Work supported by DOE

Illustrating the Steady-State Condition and the Single-Molecule Kinetic Method with the NMDA Receptor

ERIC Educational Resources Information Center

Kosman, Daniel J.

2009-01-01

The steady-state is a fundamental aspect of biochemical pathways in cells; indeed, the concept of steady-state is a definition of life itself. In a simple enzyme kinetic scheme, the steady-state condition is easy to define analytically but experimentally often difficult to capture because of its evanescent quality; the initial, constant velocity…

Steady state and a general scale law of deformation

NASA Astrophysics Data System (ADS)

Huang, Yan

2017-07-01

Steady state deformation has been characterized based on the experimental results for dilute single-phase aluminium alloys. It was found that although characteristic properties such as flow stress and grain size remained constant with time, a continuous loss of grain boundaries occurred as an essential feature at steady state. A physical model, which takes into account the activity of grain boundary dislocations, was developed to describe the kinetics of steady state deformation. According to this model, the steady state as a function of strain rate and temperature defines the limit of the conventional grain size and strength relationship, i.e., the Hall-Petch relation holds when the grain size is larger than that at the steady state, and an inverse Hall-Petch relation takes over if grain size is smaller than the steady state value. The transition between the two relationships relating grain size and strength is a phenomenon that depends on deformation conditions, rather than an intrinsic property as generally perceived. A general scale law of deformation is established accordingly.

Phased array ghost elimination (PAGE) for segmented SSFP imaging with interrupted steady-state.

PubMed

Kellman, Peter; Guttman, Michael A; Herzka, Daniel A; McVeigh, Elliot R

2002-12-01

Steady-state free precession (SSFP) has recently proven to be valuable for cardiac imaging due to its high signal-to-noise ratio and blood-myocardium contrast. Data acquired using ECG-triggered, segmented sequences during the approach to steady-state, or return to steady-state after interruption, may have ghost artifacts due to periodic k-space distortion. Schemes involving several preparatory RF pulses have been proposed to restore steady-state, but these consume imaging time during early systole. Alternatively, the phased-array ghost elimination (PAGE) method may be used to remove ghost artifacts from the first several frames. PAGE was demonstrated for cardiac cine SSFP imaging with interrupted steady-state using a simple alpha/2 magnetization preparation and storage scheme and a spatial tagging preparation.

Feasibility and Acceptability of Implementing Indirect Calorimetry Into Routine Clinical Care of Patients With Spinal Cord Injury

PubMed Central

Mayr, Hannah; Atresh, Sridhar; Kemp, Irene; Simmons, Joshua; Vivanti, Angela; Hickman, Ingrid J.

2016-01-01

Background: In the absence of reliable predictive equations, indirect calorimetry (IC) remains the gold standard for assessing energy requirements after spinal cord injury (SCI), but it is typically confined to a research setting. The purpose of this study is to assess the feasibility and acceptability of implementing IC into routine clinical care in an Australian SCI rehabilitation facility. Methods: Bedside IC (canopy hood) was performed, and patients completed an IC acceptability questionnaire (open-ended; yes/no; 5-point Likert scale). Fasted resting energy expenditure (REE) steady-state criteria were applied to assess data quality, and adherence to a test ≥20 minutes was recorded. Staff were surveyed to assess impact of IC on usual care. Results: Of 35 eligible patients, 9 declined (7 reported claustrophobia). One patient could not be tested before discharge and 25 underwent IC (84% male, injury level C2-L2, AIS A-D). Anxiety prevented one patient from completing IC, while another failed to fast. The remaining 23 patients achieved a steady-state REE (≥5 consecutive minutes with ≤10% coefficient of variation for VO2 and VCO2). Test-retest (n = 5) showed <10% variation in REE. Patients deemed the procedure acceptable, with 88% reporting a willingness to repeat IC. Eighty percent of patients and 90% of staff agreed it was acceptable for IC to be integrated into usual care. Conclusion: This study found that IC is a feasible and acceptable addition to the routine clinical care of patients recovering from SCI and may serve to improve accuracy of nutrition interventions for this patient population. PMID:29339868

Bioaccumulation factors and the steady state assumption for cesium isotopes in aquatic foodwebs near nuclear facilities.

PubMed

Rowan, D J

2013-07-01

Steady state approaches, such as transfer coefficients or bioaccumulation factors, are commonly used to model the bioaccumulation of (137)Cs in aquatic foodwebs from routine operations and releases from nuclear generating stations and other nuclear facilities. Routine releases from nuclear generating stations and facilities, however, often consist of pulses as liquid waste is stored, analyzed to ensure regulatory compliance and then released. The effect of repeated pulse releases on the steady state assumption inherent in the bioaccumulation factor approach has not been evaluated. In this study, I examine the steady state assumption for aquatic biota by analyzing data for two cesium isotopes in the same biota, one isotope in steady state (stable (133)Cs) from geologic sources and the other released in pulses ((137)Cs) from reactor operations. I also compare (137)Cs bioaccumulation factors for similar upstream populations from the same system exposed solely to weapon test (137)Cs, and assumed to be in steady state. The steady state assumption appears to be valid for small organisms at lower trophic levels (zooplankton, rainbow smelt and 0+ yellow perch) but not for older and larger fish at higher trophic levels (walleye). Attempts to account for previous exposure and retention through a biokinetics approach had a similar effect on steady state, upstream and non-steady state, downstream populations of walleye, but were ineffective in explaining the more or less constant deviation between fish with steady state exposures and non-steady state exposures of about 2-fold for all age classes of walleye. These results suggest that for large, piscivorous fish, repeated exposure to short duration, pulse releases leads to much higher (137)Cs BAFs than expected from (133)Cs BAFs for the same fish or (137)Cs BAFs for similar populations in the same system not impacted by reactor releases. These results suggest that the steady state approach should be used with caution in any situation where reactor releases are episodic or pulse in nature, even if the magnitude of these releases is small. Copyright © 2012. Published by Elsevier Ltd.

Steady shape analysis of tomographic pumping tests for characterization of aquifer heterogeneities

USGS Publications Warehouse

Bohling, Geoffrey C.; Zhan, Xiaoyong; Butler, James J.; Zheng, Li

2002-01-01

Hydraulic tomography, a procedure involving the performance of a suite of pumping tests in a tomographic format, provides information about variations in hydraulic conductivity at a level of detail not obtainable with traditional well tests. However, analysis of transient data from such a suite of pumping tests represents a substantial computational burden. Although steady state responses can be analyzed to reduce this computational burden significantly, the time required to reach steady state will often be too long for practical applications of the tomography concept. In addition, uncertainty regarding the mechanisms driving the system to steady state can propagate to adversely impact the resulting hydraulic conductivity estimates. These disadvantages of a steady state analysis can be overcome by exploiting the simplifications possible under the steady shape flow regime. At steady shape conditions, drawdown varies with time but the hydraulic gradient does not. Thus transient data can be analyzed with the computational efficiency of a steady state model. In this study, we demonstrate the value of the steady shape concept for inversion of hydraulic tomography data and investigate its robustness with respect to improperly specified boundary conditions.

Steady states and stability in metabolic networks without regulation.

PubMed

Ivanov, Oleksandr; van der Schaft, Arjan; Weissing, Franz J

2016-07-21

Metabolic networks are often extremely complex. Despite intensive efforts many details of these networks, e.g., exact kinetic rates and parameters of metabolic reactions, are not known, making it difficult to derive their properties. Considerable effort has been made to develop theory about properties of steady states in metabolic networks that are valid for any values of parameters. General results on uniqueness of steady states and their stability have been derived with specific assumptions on reaction kinetics, stoichiometry and network topology. For example, deep results have been obtained under the assumptions of mass-action reaction kinetics, continuous flow stirred tank reactors (CFSTR), concordant reaction networks and others. Nevertheless, a general theory about properties of steady states in metabolic networks is still missing. Here we make a step further in the quest for such a theory. Specifically, we study properties of steady states in metabolic networks with monotonic kinetics in relation to their stoichiometry (simple and general) and the number of metabolites participating in every reaction (single or many). Our approach is based on the investigation of properties of the Jacobian matrix. We show that stoichiometry, network topology, and the number of metabolites that participate in every reaction have a large influence on the number of steady states and their stability in metabolic networks. Specifically, metabolic networks with single-substrate-single-product reactions have disconnected steady states, whereas in metabolic networks with multiple-substrates-multiple-product reactions manifolds of steady states arise. Metabolic networks with simple stoichiometry have either a unique globally asymptotically stable steady state or asymptotically stable manifolds of steady states. In metabolic networks with general stoichiometry the steady states are not always stable and we provide conditions for their stability. In order to demonstrate the biological relevance we illustrate the results on the examples of the TCA cycle, the mevalonate pathway and the Calvin cycle. Copyright © 2016 Elsevier Ltd. All rights reserved.

Computational multiple steady states for enzymatic esterification of ethanol and oleic acid in an isothermal CSTR.

PubMed

Ho, Pang-Yen; Chuang, Guo-Syong; Chao, An-Chong; Li, Hsing-Ya

2005-05-01

The capacity of complex biochemical reaction networks (consisting of 11 coupled non-linear ordinary differential equations) to show multiple steady states, was investigated. The system involved esterification of ethanol and oleic acid by lipase in an isothermal continuous stirred tank reactor (CSTR). The Deficiency One Algorithm and the Subnetwork Analysis were applied to determine the steady state multiplicity. A set of rate constants and two corresponding steady states are computed. The phenomena of bistability, hysteresis and bifurcation are discussed. Moreover, the capacity of steady state multiplicity is extended to the family of the studied reaction networks.

An Intuitive Approach to Steady-State Kinetics.

ERIC Educational Resources Information Center

Raines, Ronald T.; Hansen, David E.

1988-01-01

Attempts to provide an intuitive understanding of steady state kinetics. Discusses the meaning of steady state and uses free energy profiles to illustrate and follow complex kinetic and thermodynamic relationships. Provides examples with explanations. (MVL)

Effect of flaw size and temperature on the matrix cracking behavior of a brittle ceramic matrix composite

DOE Office of Scientific and Technical Information (OSTI.GOV)

Anandakumar, U.; Webb, J.E.; Singh, R.N.

The matrix cracking behavior of a zircon matrix - uniaxial SCS 6 fiber composite was studied as a function of initial flaw size and temperature. The composites were fabricated by a tape casting and hot pressing technique. Surface flaws of controlled size were introduced using a vicker`s indenter. The composite samples were tested in three point flexure at three different temperatures to study the non steady state and steady state matrix cracking behavior. The composite samples exhibited steady state and non steady matrix cracking behavior at all temperatures. The steady state matrix cracking stress and steady state crack size increasedmore » with increasing temperature. The results of the study correlated well with the results predicted by the matrix cracking models.« less

Ring-Down Spectroscopy for Characterizing a CW Raman Laser

NASA Technical Reports Server (NTRS)

Matsko, Andrey; Savchenkov, Anatoliy; Maleki, Lute

2007-01-01

.A relatively simple technique for characterizing an all-resonant intracavity continuous-wave (CW) solid-state Raman laser involves the use of ring-down spectroscopy. As used here, characterizing signifies determining such parameters as threshold pump power, Raman gain, conversion efficiency, and quality factors (Q values) of the pump and Stokes cavity modes. Heretofore, in order to characterize resonant-cavity-based Raman lasers, it has usually been necessary to manipulate the frequencies and power levels of pump lasers and, in each case, to take several sets of measurements. In cases involving ultra-high-Q resonators, it also has been desirable to lock pump lasers to resonator modes to ensure the quality of measurement data. Simpler techniques could be useful. In the present ring-down spectroscopic technique, one infers the parameters of interest from the decay of the laser out of its steady state. This technique does not require changing the power or frequency of the pump laser or locking the pump laser to the resonator mode. The technique is based on a theoretical analysis of what happens when the pump laser is abruptly switched off after the Raman generation reaches the steady state. The analysis starts with differential equations for the evolution of the amplitudes of the pump and Stokes electric fields, leading to solutions for the power levels of the pump and Stokes fields as functions of time and of the aforementioned parameters. Among other things, these solutions show how the ring-down time depends, to some extent, on the electromagnetic energy accumulated in the cavity. The solutions are readily converted to relatively simple equations for the parameters as functions of quantities that can be determined from measurements of the time-dependent power levels. For example, the steady-state intracavity conversion efficiency is given by G1/G2 1 and the threshold power is given by Pin(G2/G1)2, where Pin is the steady-state input pump power immediately prior to abrupt switch-off, G1 is the initial rate of decay of the pump field, and G2 is the final rate of decay of the pump field. Hence, it is possible to determine all the parameters from a single ring-down scan, provided that the measurements taken in that scan are sufficiently accurate and complete.

Differences between automatically detected and steady-state fractional flow reserve.

PubMed

Härle, Tobias; Meyer, Sven; Vahldiek, Felix; Elsässer, Albrecht

2016-02-01

Measurement of fractional flow reserve (FFR) has become a standard diagnostic tool in the catheterization laboratory. FFR evaluation studies were based on pressure recordings during steady-state maximum hyperemia. Commercially available computer systems detect the lowest Pd/Pa ratio automatically, which might not always be measured during steady-state hyperemia. We sought to compare the automatically detected FFR and true steady-state FFR. Pressure measurement traces of 105 coronary lesions from 77 patients with intermediate coronary lesions or multivessel disease were reviewed. In all patients, hyperemia had been achieved by intravenous adenosine administration using a dosage of 140 µg/kg/min. In 42 lesions (40%) automatically detected FFR was lower than true steady-state FFR. Mean bias was 0.009 (standard deviation 0.015, limits of agreement -0.02, 0.037). In 4 lesions (3.8%) both methods lead to different treatment recommendations, in all 4 cases instantaneous wave-free ratio confirmed steady-state FFR. Automatically detected FFR was slightly lower than steady-state FFR in more than one-third of cases. Consequently, interpretation of automatically detected FFR values closely below the cutoff value requires special attention.

Steady and transient sliding under rate-and-state friction

NASA Astrophysics Data System (ADS)

Putelat, Thibaut; Dawes, Jonathan H. P.

2015-05-01

The physics of dry friction is often modelled by assuming that static and kinetic frictional forces can be represented by a pair of coefficients usually referred to as μs and μk, respectively. In this paper we re-examine this discontinuous dichotomy and relate it quantitatively to the more general, and smooth, framework of rate-and-state friction. This is important because it enables us to link the ideas behind the widely used static and dynamic coefficients to the more complex concepts that lie behind the rate-and-state framework. Further, we introduce a generic framework for rate-and-state friction that unifies different approaches found in the literature. We consider specific dynamical models for the motion of a rigid block sliding on an inclined surface. In the Coulomb model with constant dynamic friction coefficient, sliding at constant velocity is not possible. In the rate-and-state formalism steady sliding states exist, and analysing their existence and stability enables us to show that the static friction coefficient μs should be interpreted as the local maximum at very small slip rates of the steady state rate-and-state friction law. Next, we revisit the often-cited experiments of Rabinowicz (J. Appl. Phys., 22:1373-1379, 1951). Rabinowicz further developed the idea of static and kinetic friction by proposing that the friction coefficient maintains its higher and static value μs over a persistence length before dropping to the value μk. We show that there is a natural identification of the persistence length with the distance that the block slips as measured along the stable manifold of the saddle point equilibrium in the phase space of the rate-and-state dynamics. This enables us explicitly to define μs in terms of the rate-and-state variables and hence link Rabinowicz's ideas to rate-and-state friction laws. This stable manifold naturally separates two basins of attraction in the phase space: initial conditions in the first one lead to the block eventually stopping, while in the second basin of attraction the sliding motion continues indefinitely. We show that a second definition of μs is possible, compatible with the first one, as the weighted average of the rate-and-state friction coefficient over the time the block is in motion.

On the time to steady state: insights from numerical modeling

NASA Astrophysics Data System (ADS)

Goren, L.; Willett, S.; McCoy, S. W.; Perron, J.

2013-12-01

How fast do fluvial landscapes approach steady state after an application of tectonic or climatic perturbation? While theory and some numerical models predict that the celerity of the advective wave (knickpoint) controls the response time for perturbations, experiments and other landscape evolution models demonstrate that the time to steady state is much longer than the theoretically predicted response time. We posit that the longevity of transient features and the time to steady state are controlled by the stability of the topology and geometry of channel networks. Evolution of a channel network occurs by a combination of discrete capture events and continuous migration of water divides, processes, which are difficult to represent accurately in landscape evolution models. We therefore address the question of the time to steady state using the DAC landscape evolution model that solves accurately for the location of water divides, using a combination of analytical solution for hillslopes and low-order channels together with a numerical solution for higher order channels. DAC also includes an explicit capture criterion. We have tested fundamental predictions from DAC and show that modeled networks reproduce natural network characteristics such as the Hack's exponent and coefficient and the fractal dimension. We define two steady-state criteria: a topographic steady state, defined by global, pointwise steady elevation, and a topological steady state defined as the state in which no further reorganization of the drainage network takes place. Analyzing block uplift simulations, we find that the time to achieve either topographic or topological steady state exceeds by an order of magnitude the theoretical response time of the fluvial network. The longevity of the transient state is the result of the area feedback, by which, migration of a divide changes the local contributing area. This change propagates downstream as a slope adjustment, forcing further divide migrations and area change in adjacent tributaries and basins. In order to characterize the evolution of the drainage network on its way to steady state, we define a proxy to steady state elevation, χ, which is also the characteristic parameter of the transient stream power PDE. Through simulations of tectonic tilting we find that reorganization tends to minimize moments of the χ distribution of the landscape and of Δχ across divides.

Quantitative broadband absorption and scattering spectroscopy in turbid media by combined frequency-domain and steady state methodologies

DOEpatents

Tromberg, Bruce J [Irvine, CA; Berger, Andrew J [Rochester, NY; Cerussi, Albert E [Lake Forest, CA; Bevilacqua, Frederic [Costa Mesa, CA; Jakubowski, Dorota [Irvine, CA

2008-09-23

A technique for measuring broadband near-infrared absorption spectra of turbid media that uses a combination of frequency-domain and steady-state reflectance methods. Most of the wavelength coverage is provided by a white-light steady-state measurement, whereas the frequency-domain data are acquired at a few selected wavelengths. Coefficients of absorption and reduced scattering derived from the frequency-domain data are used to calibrate the intensity of the steady-state measurements and to determine the reduced scattering coefficient at all wavelengths in the spectral window of interest. The absorption coefficient spectrum is determined by comparing the steady-state reflectance values with the predictions of diffusion theory, wavelength by wavelength. Absorption spectra of a turbid phantom and of human breast tissue in vivo, derived with the combined frequency-domain and steady-state technique, agree well with expected reference values.

Steady-state entanglement in levitated optomechanical systems coupled to a higher order excited atomic ensemble

NASA Astrophysics Data System (ADS)

Chen, Aixi; Nie, Wenjie; Li, Ling; Zeng, Wei; Liao, Qinghong; Xiao, Xianbo

2017-11-01

We investigate the steady-state entanglement in an optomechanical system with a levitated dielectric nanosphere and a higher order excited atomic ensemble. The single nanosphere is trapped by an external harmonic dipole trap and coupled to the single-mode cavity field by the effective optomechanical coupling, which depends on the steady-state position of the nanosphere. We show that the steady-state optomechanical entanglement can be generated via the effective optomechanical interaction between the mechanical motion and the cavity mode. Further, these exist an optimal effective cavity detuning that maximizes the optomechanical entanglement. We also analyze in detail the influences of the excitation number of atoms, the radius of the nanosphere and the thermal noise strength on the steady-state optomechanical entanglement. It is found that the steady-state entanglement can be enhanced by increasing the excitation number of atoms and the radius of the nanosphere.

No Disk Winds in Failed Black Hole Outbursts? New Observations of H1743-322

NASA Astrophysics Data System (ADS)

Neilsen, Joseph; Coriat, Mickael; Motta, Sara; Fender, Rob P.; Ponti, Gabriele; Corbel, Stephane

2016-04-01

The rich and complex physics of stellar-mass black holes in outburst is often referred to as the "disk-jet connection," a term that encapsulates the evolution of accretion disks over several orders of magnitude in Eddington ratio; through Compton scattering, reflection, and thermal emission; as they produce steady compact jets, relativistic plasma ejections, and (from high spectral resolution revelations of the last 15 years) massive, ionized disk winds. It is well established that steady jets are associated with radiatively inefficient X-ray states, and that winds tend to appear during states with more luminous disks, but the underlying physical processes that govern these connections (and their changes during state transitions) are not fully understood. I will present a unique perspective on the disk-wind-jet connection based on new Chandra HETGS, NuSTAR, and JVLA observations of the black hole H1743-322. Rather than following the usual outburst track, the 2015 outburst of H1743 fizzled: the disk never appeared in X-rays, and the source remained spectrally hard for the entire ~100 days. Remarkably, we find no evidence for any accretion disk wind in our data, even though H1743-322 has produced winds at comparable hard X-ray luminosities. I will discuss the implications of this "failed outburst" for our picture of winds from black holes and the astrophysics that governs them.

Customized Steady-State Constraints for Parameter Estimation in Non-Linear Ordinary Differential Equation Models

PubMed Central

Rosenblatt, Marcus; Timmer, Jens; Kaschek, Daniel

2016-01-01

Ordinary differential equation models have become a wide-spread approach to analyze dynamical systems and understand underlying mechanisms. Model parameters are often unknown and have to be estimated from experimental data, e.g., by maximum-likelihood estimation. In particular, models of biological systems contain a large number of parameters. To reduce the dimensionality of the parameter space, steady-state information is incorporated in the parameter estimation process. For non-linear models, analytical steady-state calculation typically leads to higher-order polynomial equations for which no closed-form solutions can be obtained. This can be circumvented by solving the steady-state equations for kinetic parameters, which results in a linear equation system with comparatively simple solutions. At the same time multiplicity of steady-state solutions is avoided, which otherwise is problematic for optimization. When solved for kinetic parameters, however, steady-state constraints tend to become negative for particular model specifications, thus, generating new types of optimization problems. Here, we present an algorithm based on graph theory that derives non-negative, analytical steady-state expressions by stepwise removal of cyclic dependencies between dynamical variables. The algorithm avoids multiple steady-state solutions by construction. We show that our method is applicable to most common classes of biochemical reaction networks containing inhibition terms, mass-action and Hill-type kinetic equations. Comparing the performance of parameter estimation for different analytical and numerical methods of incorporating steady-state information, we show that our approach is especially well-tailored to guarantee a high success rate of optimization. PMID:27243005

Customized Steady-State Constraints for Parameter Estimation in Non-Linear Ordinary Differential Equation Models.

PubMed

Rosenblatt, Marcus; Timmer, Jens; Kaschek, Daniel

2016-01-01

Ordinary differential equation models have become a wide-spread approach to analyze dynamical systems and understand underlying mechanisms. Model parameters are often unknown and have to be estimated from experimental data, e.g., by maximum-likelihood estimation. In particular, models of biological systems contain a large number of parameters. To reduce the dimensionality of the parameter space, steady-state information is incorporated in the parameter estimation process. For non-linear models, analytical steady-state calculation typically leads to higher-order polynomial equations for which no closed-form solutions can be obtained. This can be circumvented by solving the steady-state equations for kinetic parameters, which results in a linear equation system with comparatively simple solutions. At the same time multiplicity of steady-state solutions is avoided, which otherwise is problematic for optimization. When solved for kinetic parameters, however, steady-state constraints tend to become negative for particular model specifications, thus, generating new types of optimization problems. Here, we present an algorithm based on graph theory that derives non-negative, analytical steady-state expressions by stepwise removal of cyclic dependencies between dynamical variables. The algorithm avoids multiple steady-state solutions by construction. We show that our method is applicable to most common classes of biochemical reaction networks containing inhibition terms, mass-action and Hill-type kinetic equations. Comparing the performance of parameter estimation for different analytical and numerical methods of incorporating steady-state information, we show that our approach is especially well-tailored to guarantee a high success rate of optimization.

Existence and instability of steady states for a triangular cross-diffusion system: A computer-assisted proof

NASA Astrophysics Data System (ADS)

Breden, Maxime; Castelli, Roberto

2018-05-01

In this paper, we present and apply a computer-assisted method to study steady states of a triangular cross-diffusion system. Our approach consist in an a posteriori validation procedure, that is based on using a fixed point argument around a numerically computed solution, in the spirit of the Newton-Kantorovich theorem. It allows to prove the existence of various non homogeneous steady states for different parameter values. In some situations, we obtain as many as 13 coexisting steady states. We also apply the a posteriori validation procedure to study the linear stability of the obtained steady states, proving that many of them are in fact unstable.

Flows, scaling, and the control of moment hierarchies for stochastic chemical reaction networks

NASA Astrophysics Data System (ADS)

Smith, Eric; Krishnamurthy, Supriya

2017-12-01

Stochastic chemical reaction networks (CRNs) are complex systems that combine the features of concurrent transformation of multiple variables in each elementary reaction event and nonlinear relations between states and their rates of change. Most general results concerning CRNs are limited to restricted cases where a topological characteristic known as deficiency takes a value 0 or 1, implying uniqueness and positivity of steady states and surprising, low-information forms for their associated probability distributions. Here we derive equations of motion for fluctuation moments at all orders for stochastic CRNs at general deficiency. We show, for the standard base case of proportional sampling without replacement (which underlies the mass-action rate law), that the generator of the stochastic process acts on the hierarchy of factorial moments with a finite representation. Whereas simulation of high-order moments for many-particle systems is costly, this representation reduces the solution of moment hierarchies to a complexity comparable to solving a heat equation. At steady states, moment hierarchies for finite CRNs interpolate between low-order and high-order scaling regimes, which may be approximated separately by distributions similar to those for deficiency-zero networks and connected through matched asymptotic expansions. In CRNs with multiple stable or metastable steady states, boundedness of high-order moments provides the starting condition for recursive solution downward to low-order moments, reversing the order usually used to solve moment hierarchies. A basis for a subset of network flows defined by having the same mean-regressing property as the flows in deficiency-zero networks gives the leading contribution to low-order moments in CRNs at general deficiency, in a 1 /n expansion in large particle numbers. Our results give a physical picture of the different informational roles of mean-regressing and non-mean-regressing flows and clarify the dynamical meaning of deficiency not only for first-moment conditions but for all orders in fluctuations.

Low-dimensional Representation of Error Covariance

NASA Technical Reports Server (NTRS)

Tippett, Michael K.; Cohn, Stephen E.; Todling, Ricardo; Marchesin, Dan

2000-01-01

Ensemble and reduced-rank approaches to prediction and assimilation rely on low-dimensional approximations of the estimation error covariances. Here stability properties of the forecast/analysis cycle for linear, time-independent systems are used to identify factors that cause the steady-state analysis error covariance to admit a low-dimensional representation. A useful measure of forecast/analysis cycle stability is the bound matrix, a function of the dynamics, observation operator and assimilation method. Upper and lower estimates for the steady-state analysis error covariance matrix eigenvalues are derived from the bound matrix. The estimates generalize to time-dependent systems. If much of the steady-state analysis error variance is due to a few dominant modes, the leading eigenvectors of the bound matrix approximate those of the steady-state analysis error covariance matrix. The analytical results are illustrated in two numerical examples where the Kalman filter is carried to steady state. The first example uses the dynamics of a generalized advection equation exhibiting nonmodal transient growth. Failure to observe growing modes leads to increased steady-state analysis error variances. Leading eigenvectors of the steady-state analysis error covariance matrix are well approximated by leading eigenvectors of the bound matrix. The second example uses the dynamics of a damped baroclinic wave model. The leading eigenvectors of a lowest-order approximation of the bound matrix are shown to approximate well the leading eigenvectors of the steady-state analysis error covariance matrix.

Contribution of highway capital to industry and national productivity growth

DOT National Transportation Integrated Search

1973-10-01

The report contains the authors initial efforts aimed at extending the steady state freeway model for optimizing freeway traffic flow to a non-steady state model. The steady-state model does not allow reaction to continuously changing conditions whic...

Disposal of Energy by UV-B Sunscreens

NASA Astrophysics Data System (ADS)

Nordlund, Thomas; Krishnan, Rajagopal

2008-03-01

Ideal sunscreens absorb dangerous UV light and dispose of the energy safely. ``Safe disposal'' usually means conversion to heat. However, efficient absorption entails a high radiative rate, which implies high energy-transfer and other rates, unless some process intervenes to ``defuse'' the excited state. We studied the excited-state kinetics of three UV-B (290-320 nm) sunscreens by absorption, steady-state and time-resolved fluorescence. Excited-state rate analysis suggests that some sunscreens have low radiative-rate ``dark'' states, in addition to normal excited states.* We deduce dark states when sunscreens of high extinction coefficient do not show lifetimes and total emission consistent with such high radiative rates. A high radiative rate, accompanied by efficient fluorescence emission and/or transfer, may be unfavorable for a sunscreen. In spite of its dark excited state, padimate O shows significant re-emission of light in the UV-A (320-400 nm) and energy transfer to a natural component of excised skin, probably collagen. * Krishnan, R. and T.M. Nordlund (2007) J. Fluoresc. DOI 10.1007/s10895-007-0264-3.

Critical threshold behavior for steady-state internal transport barriers in burning plasmas.

PubMed

García, J; Giruzzi, G; Artaud, J F; Basiuk, V; Decker, J; Imbeaux, F; Peysson, Y; Schneider, M

2008-06-27

Burning tokamak plasmas with internal transport barriers are investigated by means of integrated modeling simulations. The barrier sustainment in steady state, differently from the barrier formation process, is found to be characterized by a critical behavior, and the critical number of the phase transition is determined. Beyond a power threshold, alignment of self-generated and noninductively driven currents occurs and steady state becomes possible. This concept is applied to simulate a steady-state scenario within the specifications of the International Thermonuclear Experimental Reactor.

A Novel Chronic Opioid Monitoring Tool to Assess Prescription Drug Steady State Levels in Oral Fluid.

PubMed

Shaparin, Naum; Mehta, Neel; Kunkel, Frank; Stripp, Richard; Borg, Damon; Kolb, Elizabeth

2017-11-01

Interpretation limitations of urine drug testing and the invasiveness of blood toxicology have motivated the desire for the development of simpler methods to assess biologically active drug levels on an individualized patient basis. Oral fluid is a matrix well-suited for the challenge because collections are based on simple noninvasive procedures and drug concentrations better correlate to blood drug levels as oral fluid is a filtrate of the blood. Well-established pharmacokinetic models were utilized to generate oral fluid steady state concentration ranges to assess the interpretive value of the alternative matrix to monitor steady state plasma oxycodone levels. Paired oral fluid and plasma samples were collected from patients chronically prescribed oxycodone and quantitatively analyzed by liquid chromatography tandem mass spectrometry. Steady state plasma concentration ranges were calculated for each donor and converted to an equivalent range in oral fluid. Measured plasma and oral fluid oxycodone concentrations were compared with respective matrix-matched steady state ranges, using each plasma steady state classification as the control. A high degree of correlation was observed between matrices when classifying donors according to expected steady state oxycodone concentration. Agreement between plasma and oral fluid steady state classifications was observed in 75.6% of paired samples. This study supports novel application of basic pharmacokinetic knowledge to the pain management industry, simplifying and improving individualized drug monitoring and risk assessment through the use of oral fluid drug testing. Many benefits of established therapeutic drug monitoring in plasma can be realized in oral fluid for patients chronically prescribed oxycodone at steady state. © 2017 American Academy of Pain Medicine. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com

A Data Filter for Identifying Steady-State Operating Points in Engine Flight Data for Condition Monitoring Applications

NASA Technical Reports Server (NTRS)

Simon, Donald L.; Litt, Jonathan S.

2010-01-01

This paper presents an algorithm that automatically identifies and extracts steady-state engine operating points from engine flight data. It calculates the mean and standard deviation of select parameters contained in the incoming flight data stream. If the standard deviation of the data falls below defined constraints, the engine is assumed to be at a steady-state operating point, and the mean measurement data at that point are archived for subsequent condition monitoring purposes. The fundamental design of the steady-state data filter is completely generic and applicable for any dynamic system. Additional domain-specific logic constraints are applied to reduce data outliers and variance within the collected steady-state data. The filter is designed for on-line real-time processing of streaming data as opposed to post-processing of the data in batch mode. Results of applying the steady-state data filter to recorded helicopter engine flight data are shown, demonstrating its utility for engine condition monitoring applications.

Large deviation theory for the kinetics and energetics of turnover of enzyme catalysis in a chemiostatic flow.

PubMed

Das, Biswajit; Gangopadhyay, Gautam

2018-05-07

In the framework of large deviation theory, we have characterized nonequilibrium turnover statistics of enzyme catalysis in a chemiostatic flow with externally controllable parameters, like substrate injection rate and mechanical force. In the kinetics of the process, we have shown the fluctuation theorems in terms of the symmetry of the scaled cumulant generating function (SCGF) in the transient and steady state regime and a similar symmetry rule is reflected in a large deviation rate function (LDRF) as a property of the dissipation rate through boundaries. Large deviation theory also gives the thermodynamic force of a nonequilibrium steady state, as is usually recorded experimentally by a single molecule technique, which plays a key role responsible for the dynamical symmetry of the SCGF and LDRF. Using some special properties of the Legendre transformation, here, we have provided a relation between the fluctuations of fluxes and dissipation rates, and among them, the fluctuation of the turnover rate is routinely estimated but the fluctuation in the dissipation rate is yet to be characterized for small systems. Such an enzymatic reaction flow system can be a very good testing ground to systematically understand the rare events from the large deviation theory which is beyond fluctuation theorem and central limit theorem.

"We shall have to make the best of it": The conversion of Dennis Sciama

NASA Astrophysics Data System (ADS)

Hunt, James Christopher

The cosmologist Dennis W. Sciama (1926-1999) was a long-standing advocate of the steady state model of the universe. This theory, originally proposed in 1948 by Hermann Bondi, Thomas Gold, and Fred Hoyle, suggested that the universe was eternal, and unchanging on the largest scales. Contrary to the popular image of a scientist as a dispassionate, unbiased investigator of nature, Sciama fervently hoped the steady state model to be correct. In addition, and also pace the stereotypical image of a scientist, Sciama was motivated significantly by "extrascientific" or aesthetic factors in his adoption of the model. Finally, Sciama, in a stark contrast to the naive falsificationism usually presented as a virtue of the "scientific method," went through a several-year period of attempting to "save" the model from hostile data. However, Sciama abandoned the model in 1966 due to increasingly reliable data relating to the distribution of quasars. Thus the Sciama case also stands as a counterexample to irrationalist criticisms of science, according to which scientists can and will always find ways to hold on to their "pet" theories until they die, regardless of contradictory data. Sciama's conversion also sheds light on the iterative process that goes on as scientists localize and attempt to repair faults in their theories.

Improving large-scale groundwater models by considering fossil gradients

NASA Astrophysics Data System (ADS)

Schulz, Stephan; Walther, Marc; Michelsen, Nils; Rausch, Randolf; Dirks, Heiko; Al-Saud, Mohammed; Merz, Ralf; Kolditz, Olaf; Schüth, Christoph

2017-05-01

Due to limited availability of surface water, many arid to semi-arid countries rely on their groundwater resources. Despite the quasi-absence of present day replenishment, some of these groundwater bodies contain large amounts of water, which was recharged during pluvial periods of the Late Pleistocene to Early Holocene. These mostly fossil, non-renewable resources require different management schemes compared to those which are usually applied in renewable systems. Fossil groundwater is a finite resource and its withdrawal implies mining of aquifer storage reserves. Although they receive almost no recharge, some of them show notable hydraulic gradients and a flow towards their discharge areas, even without pumping. As a result, these systems have more discharge than recharge and hence are not in steady state, which makes their modelling, in particular the calibration, very challenging. In this study, we introduce a new calibration approach, composed of four steps: (i) estimating the fossil discharge component, (ii) determining the origin of fossil discharge, (iii) fitting the hydraulic conductivity with a pseudo steady-state model, and (iv) fitting the storage capacity with a transient model by reconstructing head drawdown induced by pumping activities. Finally, we test the relevance of our approach and evaluated the effect of considering or ignoring fossil gradients on aquifer parameterization for the Upper Mega Aquifer (UMA) on the Arabian Peninsula.

Time-resolved microplasma excitation temperature in a pulsed microwave discharge

NASA Astrophysics Data System (ADS)

Hopwood, Jeffrey; Monfared, Shabnam; Hoskinson, Alan

2013-09-01

Microwave-driven microplasmas are usually operated in a steady-state mode such that the electron temperature is constant in time. Transient measurements of excitation temperature and helium emission lines, however, suggest that short microwave pulses can be used to raise the electron energy by 20-30% for approximately 100 ns. Time-resolved optical emission spectrometry reveals an initial burst of light emission from the igniting microplasma. This emission overshoot is also correlated with a measured increase in excitation temperature. Excimer emission lags atomic emission, however, and does not overshoot. A simple model demonstrates that an increase in electron temperature is responsible for the overshoot of atomic optical emission at the beginning of each microwave pulse. The formation of dimers and subsequent excimer emission requires slower three-body collisions with the excited rare gas atom; this is why excimer emission does not overshoot the steady state value. Similar experimental and modeling results are observed in argon gas. The overshoot in electron temperature may be used to manipulate the collisional production of species in microplasmas using short, low-duty cycle microwave pulses. This material is based upon work supported by the USAF and Physical Sciences Inc., under contract No. FA8650-C-12-C-2312. Additional support was provided by the DARPA MPD program under award FA9550-12-1-0006.

Methodology for fault detection in induction motors via sound and vibration signals

NASA Astrophysics Data System (ADS)

Delgado-Arredondo, Paulo Antonio; Morinigo-Sotelo, Daniel; Osornio-Rios, Roque Alfredo; Avina-Cervantes, Juan Gabriel; Rostro-Gonzalez, Horacio; Romero-Troncoso, Rene de Jesus

2017-01-01

Nowadays, timely maintenance of electric motors is vital to keep up the complex processes of industrial production. There are currently a variety of methodologies for fault diagnosis. Usually, the diagnosis is performed by analyzing current signals at a steady-state motor operation or during a start-up transient. This method is known as motor current signature analysis, which identifies frequencies associated with faults in the frequency domain or by the time-frequency decomposition of the current signals. Fault identification may also be possible by analyzing acoustic sound and vibration signals, which is useful because sometimes this information is the only available. The contribution of this work is a methodology for detecting faults in induction motors in steady-state operation based on the analysis of acoustic sound and vibration signals. This proposed approach uses the Complete Ensemble Empirical Mode Decomposition for decomposing the signal into several intrinsic mode functions. Subsequently, the frequency marginal of the Gabor representation is calculated to obtain the spectral content of the IMF in the frequency domain. This proposal provides good fault detectability results compared to other published works in addition to the identification of more frequencies associated with the faults. The faults diagnosed in this work are two broken rotor bars, mechanical unbalance and bearing defects.

Fourier decomposition pulmonary MRI using a variable flip angle balanced steady-state free precession technique.

PubMed

Corteville, D M R; Kjïrstad, Å; Henzler, T; Zöllner, F G; Schad, L R

2015-05-01

Fourier decomposition (FD) is a noninvasive method for assessing ventilation and perfusion-related information in the lungs. However, the technique has a low signal-to-noise ratio (SNR) in the lung parenchyma. We present an approach to increase the SNR in both morphological and functional images. The data used to create functional FD images are usually acquired using a standard balanced steady-state free precession (bSSFP) sequence. In the standard sequence, the possible range of the flip angle is restricted due to specific absorption rate (SAR) limitations. Thus, using a variable flip angle approach as an optimization is possible. This was validated using measurements from a phantom and six healthy volunteers. The SNR in both the morphological and functional FD images was increased by 32%, while the SAR restrictions were kept unchanged. Furthermore, due to the higher SNR, the effective resolution of the functional images was increased visibly. The variable flip angle approach did not introduce any new transient artifacts, and blurring artifacts were minimized. Both a gain in SNR and an effective resolution gain in functional lung images can be obtained using the FD method in conjunction with a variable flip angle optimized bSSFP sequence. © 2014 Wiley Periodicals, Inc.

Large deviation theory for the kinetics and energetics of turnover of enzyme catalysis in a chemiostatic flow

NASA Astrophysics Data System (ADS)

Das, Biswajit; Gangopadhyay, Gautam

2018-05-01

In the framework of large deviation theory, we have characterized nonequilibrium turnover statistics of enzyme catalysis in a chemiostatic flow with externally controllable parameters, like substrate injection rate and mechanical force. In the kinetics of the process, we have shown the fluctuation theorems in terms of the symmetry of the scaled cumulant generating function (SCGF) in the transient and steady state regime and a similar symmetry rule is reflected in a large deviation rate function (LDRF) as a property of the dissipation rate through boundaries. Large deviation theory also gives the thermodynamic force of a nonequilibrium steady state, as is usually recorded experimentally by a single molecule technique, which plays a key role responsible for the dynamical symmetry of the SCGF and LDRF. Using some special properties of the Legendre transformation, here, we have provided a relation between the fluctuations of fluxes and dissipation rates, and among them, the fluctuation of the turnover rate is routinely estimated but the fluctuation in the dissipation rate is yet to be characterized for small systems. Such an enzymatic reaction flow system can be a very good testing ground to systematically understand the rare events from the large deviation theory which is beyond fluctuation theorem and central limit theorem.

Steady-State Visual Evoked Potentials Can Be Explained by Temporal Superposition of Transient Event-Related Responses

PubMed Central

Capilla, Almudena; Pazo-Alvarez, Paula; Darriba, Alvaro; Campo, Pablo; Gross, Joachim

2011-01-01

Background One common criterion for classifying electrophysiological brain responses is based on the distinction between transient (i.e. event-related potentials, ERPs) and steady-state responses (SSRs). The generation of SSRs is usually attributed to the entrainment of a neural rhythm driven by the stimulus train. However, a more parsimonious account suggests that SSRs might result from the linear addition of the transient responses elicited by each stimulus. This study aimed to investigate this possibility. Methodology/Principal Findings We recorded brain potentials elicited by a checkerboard stimulus reversing at different rates. We modeled SSRs by sequentially shifting and linearly adding rate-specific ERPs. Our results show a strong resemblance between recorded and synthetic SSRs, supporting the superposition hypothesis. Furthermore, we did not find evidence of entrainment of a neural oscillation at the stimulation frequency. Conclusions/Significance This study provides evidence that visual SSRs can be explained as a superposition of transient ERPs. These findings have critical implications in our current understanding of brain oscillations. Contrary to the idea that neural networks can be tuned to a wide range of frequencies, our findings rather suggest that the oscillatory response of a given neural network is constrained within its natural frequency range. PMID:21267081

Sensitivity Analysis for Steady State Groundwater Flow Using Adjoint Operators

NASA Astrophysics Data System (ADS)

Sykes, J. F.; Wilson, J. L.; Andrews, R. W.

1985-03-01

Adjoint sensitivity theory is currently being considered as a potential method for calculating the sensitivity of nuclear waste repository performance measures to the parameters of the system. For groundwater flow systems, performance measures of interest include piezometric heads in the vicinity of a waste site, velocities or travel time in aquifers, and mass discharge to biosphere points. The parameters include recharge-discharge rates, prescribed boundary heads or fluxes, formation thicknesses, and hydraulic conductivities. The derivative of a performance measure with respect to the system parameters is usually taken as a measure of sensitivity. To calculate sensitivities, adjoint sensitivity equations are formulated from the equations describing the primary problem. The solution of the primary problem and the adjoint sensitivity problem enables the determination of all of the required derivatives and hence related sensitivity coefficients. In this study, adjoint sensitivity theory is developed for equations of two-dimensional steady state flow in a confined aquifer. Both the primary flow equation and the adjoint sensitivity equation are solved using the Galerkin finite element method. The developed computer code is used to investigate the regional flow parameters of the Leadville Formation of the Paradox Basin in Utah. The results illustrate the sensitivity of calculated local heads to the boundary conditions. Alternatively, local velocity related performance measures are more sensitive to hydraulic conductivities.

Tailored parameter optimization methods for ordinary differential equation models with steady-state constraints.

PubMed

Fiedler, Anna; Raeth, Sebastian; Theis, Fabian J; Hausser, Angelika; Hasenauer, Jan

2016-08-22

Ordinary differential equation (ODE) models are widely used to describe (bio-)chemical and biological processes. To enhance the predictive power of these models, their unknown parameters are estimated from experimental data. These experimental data are mostly collected in perturbation experiments, in which the processes are pushed out of steady state by applying a stimulus. The information that the initial condition is a steady state of the unperturbed process provides valuable information, as it restricts the dynamics of the process and thereby the parameters. However, implementing steady-state constraints in the optimization often results in convergence problems. In this manuscript, we propose two new methods for solving optimization problems with steady-state constraints. The first method exploits ideas from optimization algorithms on manifolds and introduces a retraction operator, essentially reducing the dimension of the optimization problem. The second method is based on the continuous analogue of the optimization problem. This continuous analogue is an ODE whose equilibrium points are the optima of the constrained optimization problem. This equivalence enables the use of adaptive numerical methods for solving optimization problems with steady-state constraints. Both methods are tailored to the problem structure and exploit the local geometry of the steady-state manifold and its stability properties. A parameterization of the steady-state manifold is not required. The efficiency and reliability of the proposed methods is evaluated using one toy example and two applications. The first application example uses published data while the second uses a novel dataset for Raf/MEK/ERK signaling. The proposed methods demonstrated better convergence properties than state-of-the-art methods employed in systems and computational biology. Furthermore, the average computation time per converged start is significantly lower. In addition to the theoretical results, the analysis of the dataset for Raf/MEK/ERK signaling provides novel biological insights regarding the existence of feedback regulation. Many optimization problems considered in systems and computational biology are subject to steady-state constraints. While most optimization methods have convergence problems if these steady-state constraints are highly nonlinear, the methods presented recover the convergence properties of optimizers which can exploit an analytical expression for the parameter-dependent steady state. This renders them an excellent alternative to methods which are currently employed in systems and computational biology.

40 CFR 1039.505 - How do I test engines using steady-state duty cycles, including ramped-modal testing?

Code of Federal Regulations, 2010 CFR

2010-07-01

...-state duty cycles, including ramped-modal testing? 1039.505 Section 1039.505 Protection of Environment... duty cycles, including ramped-modal testing? This section describes how to test engines under steady-state conditions. In some cases, we allow you to choose the appropriate steady-state duty cycle for an...

The Markov process admits a consistent steady-state thermodynamic formalism

NASA Astrophysics Data System (ADS)

Peng, Liangrong; Zhu, Yi; Hong, Liu

2018-01-01

The search for a unified formulation for describing various non-equilibrium processes is a central task of modern non-equilibrium thermodynamics. In this paper, a novel steady-state thermodynamic formalism was established for general Markov processes described by the Chapman-Kolmogorov equation. Furthermore, corresponding formalisms of steady-state thermodynamics for the master equation and Fokker-Planck equation could be rigorously derived in mathematics. To be concrete, we proved that (1) in the limit of continuous time, the steady-state thermodynamic formalism for the Chapman-Kolmogorov equation fully agrees with that for the master equation; (2) a similar one-to-one correspondence could be established rigorously between the master equation and Fokker-Planck equation in the limit of large system size; (3) when a Markov process is restrained to one-step jump, the steady-state thermodynamic formalism for the Fokker-Planck equation with discrete state variables also goes to that for master equations, as the discretization step gets smaller and smaller. Our analysis indicated that general Markov processes admit a unified and self-consistent non-equilibrium steady-state thermodynamic formalism, regardless of underlying detailed models.

Stabilization of a spatially uniform steady state in two systems exhibiting Turing patterns

NASA Astrophysics Data System (ADS)

Konishi, Keiji; Hara, Naoyuki

2018-05-01

This paper deals with the stabilization of a spatially uniform steady state in two coupled one-dimensional reaction-diffusion systems with Turing instability. This stabilization corresponds to amplitude death that occurs in a coupled system with Turing instability. Stability analysis of the steady state shows that stabilization does not occur if the two reaction-diffusion systems are identical. We derive a sufficient condition for the steady state to be stable for any length of system and any boundary conditions. Our analytical results are supported with numerical examples.

Pseudo-compressibility methods for the incompressible flow equations

NASA Technical Reports Server (NTRS)

Turkel, Eli; Arnone, A.

1993-01-01

Preconditioning methods to accelerate convergence to a steady state for the incompressible fluid dynamics equations are considered. The analysis relies on the inviscid equations. The preconditioning consists of a matrix multiplying the time derivatives. Thus the steady state of the preconditioned system is the same as the steady state of the original system. The method is compared to other types of pseudo-compressibility. For finite difference methods preconditioning can change and improve the steady state solutions. An application to viscous flow around a cascade with a non-periodic mesh is presented.

Quantum thermodynamics of nanoscale steady states far from equilibrium

NASA Astrophysics Data System (ADS)

Taniguchi, Nobuhiko

2018-04-01

We develop an exact quantum thermodynamic description for a noninteracting nanoscale steady state that couples strongly with multiple reservoirs. We demonstrate that there exists a steady-state extension of the thermodynamic function that correctly accounts for the multiterminal Landauer-Büttiker formula of quantum transport of charge, energy, or heat via the nonequilibrium thermodynamic relations. Its explicit form is obtained for a single bosonic or fermionic level in the wide-band limit, and corresponding thermodynamic forces (affinities) are identified. Nonlinear generalization of the Onsager reciprocity relations are derived. We suggest that the steady-state thermodynamic function is also capable of characterizing the heat current fluctuations of the critical transport where the thermal fluctuations dominate. Also, the suggested nonequilibrium steady-state thermodynamic relations seemingly persist for a spin-degenerate single level with local interaction.

Integration of Steady-State and Temporal Gene Expression Data for the Inference of Gene Regulatory Networks

PubMed Central

Wang, Yi Kan; Hurley, Daniel G.; Schnell, Santiago; Print, Cristin G.; Crampin, Edmund J.

2013-01-01

We develop a new regression algorithm, cMIKANA, for inference of gene regulatory networks from combinations of steady-state and time-series gene expression data. Using simulated gene expression datasets to assess the accuracy of reconstructing gene regulatory networks, we show that steady-state and time-series data sets can successfully be combined to identify gene regulatory interactions using the new algorithm. Inferring gene networks from combined data sets was found to be advantageous when using noisy measurements collected with either lower sampling rates or a limited number of experimental replicates. We illustrate our method by applying it to a microarray gene expression dataset from human umbilical vein endothelial cells (HUVECs) which combines time series data from treatment with growth factor TNF and steady state data from siRNA knockdown treatments. Our results suggest that the combination of steady-state and time-series datasets may provide better prediction of RNA-to-RNA interactions, and may also reveal biological features that cannot be identified from dynamic or steady state information alone. Finally, we consider the experimental design of genomics experiments for gene regulatory network inference and show that network inference can be improved by incorporating steady-state measurements with time-series data. PMID:23967277

Oxidation and Volatilization of Silica-Formers in Water Vapor

NASA Technical Reports Server (NTRS)

Opila, E. J.; Gray, Hugh R. (Technical Monitor)

2002-01-01

At high temperatures SiC and Si3N4 react with water vapor to form a silica scale. Silica scales also react with water vapor to form a volatile Si(OH)4 species. These simultaneous reactions, one forming silica and the other removing silica, are described by paralinear kinetics. A steady state, in which these reactions occur at the same rate, is eventually achieved, After steady state is achieved, the oxide found on the surface is a constant thickness and recession of the underlying material occurs at a linear rate. The steady state oxide thickness, the time to achieve steady state, and the steady state recession rate can all be described in terms of the rate constants for the oxidation and volatilization reactions. In addition, the oxide thickness, the time to achieve steady state, and the recession rate can also be determined from parameters that describe a water vapor-containing environment. Accordingly, maps have been developed to show these steady state conditions as a function of reaction rate constants, pressure, and gas velocity. These maps can be used to predict the behavior of silica formers in water-vapor containing environments such as combustion environments. Finally, these maps are used to explore the limits of the paralinear oxidation model for SiC and Si3N4

X-Ray Spectral Analysis of the Steady States of GRS1915+105

NASA Astrophysics Data System (ADS)

Peris, Charith S.; Remillard, Ronald A.; Steiner, James F.; Vrtilek, Saeqa D.; Varnière, Peggy; Rodriguez, Jerome; Pooley, Guy

2016-05-01

We report on the X-ray spectral behavior within the steady states of GRS1915+105. Our work is based on the full data set of the source obtained using the Proportional Counter Array (PCA) on the Rossi X-ray Timing Explorer (RXTE) and 15 GHz radio data obtained using the Ryle Telescope. The steady observations within the X-ray data set naturally separated into two regions in the color-color diagram and we refer to these regions as steady-soft and steady-hard. GRS1915+105 displays significant curvature in the coronal component in both the soft and hard data within the RXTE/PCA bandpass. A majority of the steady-soft observations displays a roughly constant inner disk radius ({R}{{in}}), while the steady-hard observations display an evolving disk truncation which is correlated to the mass accretion rate through the disk. The disk flux and coronal flux are strongly correlated in steady-hard observations and very weakly correlated in the steady-soft observations. Within the steady-hard observations, we observe two particular circumstances when there are correlations between the coronal X-ray flux and the radio flux with log slopes η ˜ 0.68+/- 0.35 and η ˜ 1.12+/- 0.13. They are consistent with the upper and lower tracks of Gallo et al. (2012), respectively. A comparison of the model parameters to the state definitions shows that almost all of the steady-soft observations match the criteria of either a thermal or steep power-law state, while a large portion of the steady-hard observations match the hard-state criteria when the disk fraction constraint is neglected.

Application of cosmic-ray shock theories to the Cygnus Loop - an alternative model

NASA Astrophysics Data System (ADS)

Boulares, Ahmed; Cox, Donald P.

1988-10-01

Steady state cosmic-ray shock models are investigated in light of observations of the Cygnus Loop supernova remnant. In this work the authors find that the model of Völk, Drury, and McKenzie, in which the plasma waves are generated by the streaming instability of the cosmic rays and are dissipated into the gas, can be made consistent with some observed characteristics of Cygnus Loop shocks. The waves heat the gas substantially in the cosmic-ray precursor, in addition to the usual heating in the (possibly weak) gas shock. The model is used to deduce upstream densities and shock velocities using known quantities for Cygnus Loop shocks. Compared to the usual pure gas shock interpretation, it is found that lower densities and approximately 3 times higher velocities are required. If the cosmic-ray models are valid, this could significantly alter our understanding of the Cygnus Loop's distance and age and of the energy released during the initial explosion.

40 CFR 1048.505 - How do I test engines using steady-state duty cycles, including ramped-modal testing?

Code of Federal Regulations, 2010 CFR

2010-07-01

...-state duty cycles, including ramped-modal testing? 1048.505 Section 1048.505 Protection of Environment... SPARK-IGNITION ENGINES Test Procedures § 1048.505 How do I test engines using steady-state duty cycles... some cases, we allow you to choose the appropriate steady-state duty cycle for an engine. In these...

X-ray spectral analysis of the steady states of GRS 1915+105

NASA Astrophysics Data System (ADS)

Peris, Charith; Remillard, Ronald A.; Steiner, James F.; Vrtilek, Saeqa Dil; Varniere, Peggy; Rodriguez, Jerome; Pooley, Guy G.

2016-04-01

Of the black hole binaries (BHBs) discovered thus far, GRS 1915+105 stands out as an exceptional source primarily due to its wild X-ray variability, the diversity of which has not been replicated in any other stellar-mass black hole. Although extreme variability is commonplace in its light-curve, about half of the observations of GRS1915+105 show fairly steady X-ray intensity. We report on the X-ray spectral behavior within these steady observations. Our work is based on a vast RXTE/PCA data set obtained on GRS 1915+105 during the course of its entire mission and 10 years of radio data from the Ryle Telescope, which overlap the X-ray data. We find that the steady observations within the X-ray data set naturally separate into two regions in a color-color diagram, which we refer to as steady-soft and steady-hard. GRS 1915+105 displays significant curvature in the Comptonization component within the PCA band pass suggesting significantly heating from a hot disk present in all states. A new Comptonization model 'simplcut' was developed in order to model this curvature to best effect. A majority of the steady-soft observations display a roughly constant inner disk radius, remarkably reminiscent of canonical soft state black hole binaries. In contrast, the steady-hard observations display a growing disk truncation that is correlated to the mass accretion rate through the disk, which suggests a magnetically truncated disk. A comparison of X-ray model parameters to the canonical state definitions show that almost all steady-soft observations match the criteria of either thermal or steep power law state, while the thermal state observations dominate the constant radius branch. A large portion 80 % of the steady-hard observations matches the hard state criteria when the disk fraction constraint is neglected. These results combine to suggest that within the complexity of this source is a simpler underlying basis of states, which map to those observed in canonical BHBs.

40 CFR 86.1363-2007 - Steady-state testing with a discrete-mode cycle.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 40 Protection of Environment 19 2010-07-01 2010-07-01 false Steady-state testing with a discrete-mode cycle. 86.1363-2007 Section 86.1363-2007 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY... Exhaust Test Procedures § 86.1363-2007 Steady-state testing with a discrete-mode cycle. This section...

AEROSOL GROWTH IN A STEADY-STATE, CONTINUOUS FLOW CHAMBER: APPLICATION TO STUDIES OF SECONDARY AEROSOL FORMATION

EPA Science Inventory

An analytical solution for the steady-state aerosol size distribution achieved in a steady-state, continuous flow chamber is derived, where particle growth is occurring by gas-to-particle conversion and particle loss is occurring by deposition to the walls of the chamber. The s...

Analytical Solution of Steady State Equations for Chemical Reaction Networks with Bilinear Rate Laws

PubMed Central

Halász, Ádám M.; Lai, Hong-Jian; McCabe, Meghan M.; Radhakrishnan, Krishnan; Edwards, Jeremy S.

2014-01-01

True steady states are a rare occurrence in living organisms, yet their knowledge is essential for quasi-steady state approximations, multistability analysis, and other important tools in the investigation of chemical reaction networks (CRN) used to describe molecular processes on the cellular level. Here we present an approach that can provide closed form steady-state solutions to complex systems, resulting from CRN with binary reactions and mass-action rate laws. We map the nonlinear algebraic problem of finding steady states onto a linear problem in a higher dimensional space. We show that the linearized version of the steady state equations obeys the linear conservation laws of the original CRN. We identify two classes of problems for which complete, minimally parameterized solutions may be obtained using only the machinery of linear systems and a judicious choice of the variables used as free parameters. We exemplify our method, providing explicit formulae, on CRN describing signal initiation of two important types of RTK receptor-ligand systems, VEGF and EGF-ErbB1. PMID:24334389

Rayleigh-type parametric chemical oscillation.

PubMed

Ghosh, Shyamolina; Ray, Deb Shankar

2015-09-28

We consider a nonlinear chemical dynamical system of two phase space variables in a stable steady state. When the system is driven by a time-dependent sinusoidal forcing of a suitable scaling parameter at a frequency twice the output frequency and the strength of perturbation exceeds a threshold, the system undergoes sustained Rayleigh-type periodic oscillation, wellknown for parametric oscillation in pipe organs and distinct from the usual forced quasiperiodic oscillation of a damped nonlinear system where the system is oscillatory even in absence of any external forcing. Our theoretical analysis of the parametric chemical oscillation is corroborated by full numerical simulation of two well known models of chemical dynamics, chlorite-iodine-malonic acid and iodine-clock reactions.

Accuracy versus convergence rates for a three dimensional multistage Euler code

NASA Technical Reports Server (NTRS)

Turkel, Eli

1988-01-01

Using a central difference scheme, it is necessary to add an artificial viscosity in order to reach a steady state. This viscosity usually consists of a linear fourth difference to eliminate odd-even oscillations and a nonlinear second difference to suppress oscillations in the neighborhood of steep gradients. There are free constants in these differences. As one increases the artificial viscosity, the high modes are dissipated more and the scheme converges more rapidly. However, this higher level of viscosity smooths the shocks and eliminates other features of the flow. Thus, there is a conflict between the requirements of accuracy and efficiency. Examples are presented for a variety of three-dimensional inviscid solutions over isolated wings.

MATHEMATICAL ANALYSIS OF STEADY-STATE SOLUTIONS IN COMPARTMENT AND CONTINUUM MODELS OF CELL POLARIZATION

PubMed Central

ZHENG, ZHENZHEN; CHOU, CHING-SHAN; YI, TAU-MU; NIE, QING

2013-01-01

Cell polarization, in which substances previously uniformly distributed become asymmetric due to external or/and internal stimulation, is a fundamental process underlying cell mobility, cell division, and other polarized functions. The yeast cell S. cerevisiae has been a model system to study cell polarization. During mating, yeast cells sense shallow external spatial gradients and respond by creating steeper internal gradients of protein aligned with the external cue. The complex spatial dynamics during yeast mating polarization consists of positive feedback, degradation, global negative feedback control, and cooperative effects in protein synthesis. Understanding such complex regulations and interactions is critical to studying many important characteristics in cell polarization including signal amplification, tracking dynamic signals, and potential trade-off between achieving both objectives in a robust fashion. In this paper, we study some of these questions by analyzing several models with different spatial complexity: two compartments, three compartments, and continuum in space. The step-wise approach allows detailed characterization of properties of the steady state of the system, providing more insights for biological regulations during cell polarization. For cases without membrane diffusion, our study reveals that increasing the number of spatial compartments results in an increase in the number of steady-state solutions, in particular, the number of stable steady-state solutions, with the continuum models possessing infinitely many steady-state solutions. Through both analysis and simulations, we find that stronger positive feedback, reduced diffusion, and a shallower ligand gradient all result in more steady-state solutions, although most of these are not optimally aligned with the gradient. We explore in the different settings the relationship between the number of steady-state solutions and the extent and accuracy of the polarization. Taken together these results furnish a detailed description of the factors that influence the tradeoff between a single correctly aligned but poorly polarized stable steady-state solution versus multiple more highly polarized stable steady-state solutions that may be incorrectly aligned with the external gradient. PMID:21936604

An exact solution for the steady state phase distribution in an array of oscillators coupled on a hexagonal lattice

NASA Technical Reports Server (NTRS)

Pogorzelski, Ronald J.

2004-01-01

When electronic oscillators are coupled to nearest neighbors to form an array on a hexagonal lattice, the planar phase distributions desired for excitation of a phased array antenna are not steady state solutions of the governing non-linear equations describing the system. Thus the steady state phase distribution deviates from planar. It is shown to be possible to obtain an exact solution for the steady state phase distribution and thus determine the deviation from the desired planar distribution as a function of beam steering angle.

Preconditioning and the limit to the incompressible flow equations

NASA Technical Reports Server (NTRS)

Turkel, E.; Fiterman, A.; Vanleer, B.

1993-01-01

The use of preconditioning methods to accelerate the convergence to a steady state for both the incompressible and compressible fluid dynamic equations are considered. The relation between them for both the continuous problem and the finite difference approximation is also considered. The analysis relies on the inviscid equations. The preconditioning consists of a matrix multiplying the time derivatives. Hence, the steady state of the preconditioned system is the same as the steady state of the original system. For finite difference methods the preconditioning can change and improve the steady state solutions. An application to flow around an airfoil is presented.

Theoretical studies of solar-pumped lasers

NASA Technical Reports Server (NTRS)

Harries, W. L.

1982-01-01

Solar-pumped lasers were investigated by comparing experimental results from pulse experiments with steady state calculations. The time varying behavior of an IBr laser is studied. The analysis is only approximate, but indicates that conditions occurring in a pulsed experiment are quite different from those at steady state. The possibility of steady-state lasing in an IBr laser is determined. The effects of high temperatures on the quenching and recombination rates are examined. Although uncertainties in the values of the rate coefficients make it difficult to draw firm conclusions, it seems steady state running may be possible at high temperatures.

Parallel Tracks as Quasi-steady States for the Magnetic Boundary Layers in Neutron-star Low-mass X-Ray Binaries

DOE Office of Scientific and Technical Information (OSTI.GOV)

Erkut, M. Hakan; Çatmabacak, Onur, E-mail: mherkut@gmail.com

The neutron stars in low-mass X-ray binaries (LMXBs) are usually thought to be weakly magnetized objects accreting matter from their low-mass companions in the form of a disk. Albeit weak compared to those in young neutron-star systems, the neutron-star magnetospheres in LMXBs can play an important role in determining the correlations between spectral and temporal properties. Parallel tracks appearing in the kilohertz (kHz) quasi-periodic oscillation (QPO) frequency versus X-ray flux plane can be used as a tool to study the magnetosphere–disk interaction in neutron-star LMXBs. For dynamically important weak fields, the formation of a non-Keplerian magnetic boundary layer at themore » innermost disk truncated near the surface of the neutron star is highly likely. Such a boundary region may harbor oscillatory modes of frequencies in the kHz range. We generate parallel tracks using the boundary region model of kHz QPOs. We also present the direct application of our model to the reproduction of the observed parallel tracks of individual sources such as 4U 1608–52, 4U 1636–53, and Aql X-1. We reveal how the radial width of the boundary layer must vary in the long-term flux evolution of each source to regenerate the parallel tracks. The run of the radial width looks similar for different sources and can be fitted by a generic model function describing the average steady behavior of the boundary region over the long term. The parallel tracks then correspond to the possible quasi-steady states the source can occupy around the average trend.« less

Parallel Tracks as Quasi-steady States for the Magnetic Boundary Layers in Neutron-star Low-mass X-Ray Binaries

NASA Astrophysics Data System (ADS)

Erkut, M. Hakan; Çatmabacak, Onur

2017-11-01

The neutron stars in low-mass X-ray binaries (LMXBs) are usually thought to be weakly magnetized objects accreting matter from their low-mass companions in the form of a disk. Albeit weak compared to those in young neutron-star systems, the neutron-star magnetospheres in LMXBs can play an important role in determining the correlations between spectral and temporal properties. Parallel tracks appearing in the kilohertz (kHz) quasi-periodic oscillation (QPO) frequency versus X-ray flux plane can be used as a tool to study the magnetosphere-disk interaction in neutron-star LMXBs. For dynamically important weak fields, the formation of a non-Keplerian magnetic boundary layer at the innermost disk truncated near the surface of the neutron star is highly likely. Such a boundary region may harbor oscillatory modes of frequencies in the kHz range. We generate parallel tracks using the boundary region model of kHz QPOs. We also present the direct application of our model to the reproduction of the observed parallel tracks of individual sources such as 4U 1608-52, 4U 1636-53, and Aql X-1. We reveal how the radial width of the boundary layer must vary in the long-term flux evolution of each source to regenerate the parallel tracks. The run of the radial width looks similar for different sources and can be fitted by a generic model function describing the average steady behavior of the boundary region over the long term. The parallel tracks then correspond to the possible quasi-steady states the source can occupy around the average trend.

40 CFR Appendix C to Subpart S of... - Steady-State Short Test Standards

Code of Federal Regulations, 2010 CFR

2010-07-01

... 40 Protection of Environment 2 2010-07-01 2010-07-01 false Steady-State Short Test Standards C Appendix C to Subpart S of Part 51 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED.../Maintenance Program Requirements Pt. 51, Subpt. S, App. C Appendix C to Subpart S of Part 51—Steady-State...

40 CFR Appendix II to Part 1039 - Steady-State Duty Cycles

Code of Federal Regulations, 2010 CFR

2010-07-01

... 40 Protection of Environment 32 2010-07-01 2010-07-01 false Steady-State Duty Cycles II Appendix... Appendix II to Part 1039—Steady-State Duty Cycles (a) The following duty cycles apply for constant-speed engines: (1) The following duty cycle applies for discrete-mode testing: D2 mode number Engine speed...

40 CFR Appendix C to Subpart S of... - Steady-State Short Test Standards

Code of Federal Regulations, 2014 CFR

2014-07-01

... 40 Protection of Environment 2 2014-07-01 2014-07-01 false Steady-State Short Test Standards C Appendix C to Subpart S of Part 51 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED.../Maintenance Program Requirements Pt. 51, Subpt. S, App. C Appendix C to Subpart S of Part 51—Steady-State...

40 CFR Appendix C to Subpart S of... - Steady-State Short Test Standards

Code of Federal Regulations, 2012 CFR

2012-07-01

... 40 Protection of Environment 2 2012-07-01 2012-07-01 false Steady-State Short Test Standards C Appendix C to Subpart S of Part 51 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED.../Maintenance Program Requirements Pt. 51, Subpt. S, App. C Appendix C to Subpart S of Part 51—Steady-State...

40 CFR Appendix II to Part 1039 - Steady-State Duty Cycles

Code of Federal Regulations, 2011 CFR

2011-07-01

... Appendix II to Part 1039—Steady-State Duty Cycles (a) The following duty cycles apply for constant-speed engines: (1) The following duty cycle applies for discrete-mode testing: D2 mode number Engine speed...(seconds) Engine speed Torque(percent) 1, 2 1a Steady-state 53 Engine governed 100. 1b Transition 20 Engine...

Steady-state and quench-dependent relaxation of a quantum dot coupled to one-dimensional leads

NASA Astrophysics Data System (ADS)

Nuss, Martin; Ganahl, Martin; Evertz, Hans Gerd; Arrigoni, Enrico; von der Linden, Wolfgang

2013-07-01

We study the time evolution and steady state of the charge current in a single-impurity Anderson model, using matrix product states techniques. A nonequilibrium situation is imposed by applying a bias voltage across one-dimensional tight-binding leads. Focusing on particle-hole symmetry, we extract current-voltage characteristics from universal low-bias up to high-bias regimes, where band effects start to play a dominant role. We discuss three quenches, which after strongly quench-dependent transients yield the same steady-state current. Among these quenches we identify those favorable for extracting steady-state observables. The period of short-time oscillations is shown to compare well to real-time renormalization group results for a simpler model of spinless fermions. We find indications that many-body effects play an important role at high-bias voltage and finite bandwidth of the metallic leads. The growth of entanglement entropy after a certain time scale ∝Δ-1 is the major limiting factor for calculating the time evolution. We show that the magnitude of the steady-state current positively correlates with entanglement entropy. The role of high-energy states for the steady-state current is explored by considering a damping term in the time evolution.

Steady-state pattern electroretinogram and short-duration transient visual evoked potentials in glaucomatous and healthy eyes.

PubMed

Amarasekera, Dilru C; Resende, Arthur F; Waisbourd, Michael; Puri, Sanjeev; Moster, Marlene R; Hark, Lisa A; Katz, L Jay; Fudemberg, Scott J; Mantravadi, Anand V

2018-01-01

This study evaluates two rapid electrophysiological glaucoma diagnostic tests that may add a functional perspective to glaucoma diagnosis. This study aimed to determine the ability of two office-based electrophysiological diagnostic tests, steady-state pattern electroretinogram and short-duration transient visual evoked potentials, to discern between glaucomatous and healthy eyes. This is a cross-sectional study in a hospital setting. Forty-one patients with glaucoma and 41 healthy volunteers participated in the study. Steady-state pattern electroretinogram and short-duration transient visual evoked potential testing was conducted in glaucomatous and healthy eyes. A 64-bar-size stimulus with both a low-contrast and high-contrast setting was used to compare steady-state pattern electroretinogram parameters in both groups. A low-contrast and high-contrast checkerboard stimulus was used to measure short-duration transient visual evoked potential parameters in both groups. Steady-state pattern electroretinogram parameters compared were MagnitudeD, MagnitudeD/Magnitude ratio, and the signal-to-noise ratio. Short-duration transient visual evoked potential parameters compared were amplitude and latency. MagnitudeD was significantly lower in glaucoma patients when using a low-contrast (P = 0.001) and high-contrast (P < 0.001) 64-bar-size steady-state pattern electroretinogram stimulus. MagnitudeD/Magnitude ratio and SNR were significantly lower in the glaucoma group when using a high-contrast 64-bar-size stimulus (P < 0.001 and P = 0.010, respectively). Short-duration transient visual evoked potential amplitude and latency were not significantly different between the two groups. Steady-state pattern electroretinogram was effectively able to discern between glaucomatous and healthy eyes. Steady-state pattern electroretinogram may thus have a role as a clinically useful electrophysiological diagnostic tool. © 2017 Royal Australian and New Zealand College of Ophthalmologists.

Time density curve analysis for C-arm FDCT PBV imaging.

PubMed

Kamran, Mudassar; Byrne, James V

2016-04-01

Parenchymal blood volume (PBV) estimation using C-arm flat detector computed tomography (FDCT) assumes a steady-state contrast concentration in cerebral vasculature for the scan duration. Using time density curve (TDC) analysis, we explored if the steady-state assumption is met for C-arm CT PBV scans, and how consistent the contrast-material dynamics in cerebral vasculature are across patients. Thirty C-arm FDCT datasets of 26 patients with aneurysmal-SAH, acquired as part of a prospective study comparing C-arm CT PBV with MR-PWI, were analysed. TDCs were extracted from the 2D rotational projections. Goodness-of-fit of TDCs to a steady-state horizontal-line-model and the statistical similarity among the individual TDCs were tested. Influence of the differences in TDC characteristics on the agreement of resulting PBV measurements with MR-CBV was calculated. Despite identical scan parameters and contrast-injection-protocol, the individual TDCs were statistically non-identical (p < 0.01). Using Dunn's multiple comparisons test, of the total 435 individual comparisons among the 30 TDCs, 330 comparisons (62%) reached statistical significance for difference. All TDCs deviated significantly (p < 0.01) from the steady-state horizontal-line-model. PBV values of those datasets for which the TDCs showed largest deviations from the steady-state model demonstrated poor agreement and correlation with MR-CBV, compared with the PBV values of those datasets for which the TDCs were closer to steady-state. For clinical C-arm CT PBV examinations, the administered contrast material does not reach the assumed 'ideal steady-state' for the duration of scan. Using a prolonged injection protocol, the degree to which the TDCs approximate the ideal steady-state influences the agreement of resulting PBV measurements with MR-CBV. © The Author(s) 2016.

Prediction of elemental creep. [steady state and cyclic data from regression analysis

NASA Technical Reports Server (NTRS)

Davis, J. W.; Rummler, D. R.

1975-01-01

Cyclic and steady-state creep tests were performed to provide data which were used to develop predictive equations. These equations, describing creep as a function of stress, temperature, and time, were developed through the use of a least squares regression analyses computer program for both the steady-state and cyclic data sets. Comparison of the data from the two types of tests, revealed that there was no significant difference between the cyclic and steady-state creep strains for the L-605 sheet under the experimental conditions investigated (for the same total time at load). Attempts to develop a single linear equation describing the combined steady-state and cyclic creep data resulted in standard errors of estimates higher than obtained for the individual data sets. A proposed approach to predict elemental creep in metals uses the cyclic creep equation and a computer program which applies strain and time hardening theories of creep accumulation.

Absolute Steady-State Thermal Conductivity Measurements by Use of a Transient Hot-Wire System.

PubMed

Roder, H M; Perkins, R A; Laesecke, A; Nieto de Castro, C A

2000-01-01

A transient hot-wire apparatus was used to measure the thermal conductivity of argon with both steady-state and transient methods. The effects of wire diameter, eccentricity of the wire in the cavity, axial conduction, and natural convection were accounted for in the analysis of the steady-state measurements. Based on measurements on argon, the relative uncertainty at the 95 % level of confidence of the new steady-state measurements is 2 % at low densities. Using the same hot wires, the relative uncertainty of the transient measurements is 1 % at the 95 % level of confidence. This is the first report of thermal conductivity measurements made by two different methods in the same apparatus. The steady-state method is shown to complement normal transient measurements at low densities, particularly for fluids where the thermophysical properties at low densities are not known with high accuracy.

Quasi steady-state aerodynamic model development for race vehicle simulations

NASA Astrophysics Data System (ADS)

Mohrfeld-Halterman, J. A.; Uddin, M.

2016-01-01

Presented in this paper is a procedure to develop a high fidelity quasi steady-state aerodynamic model for use in race car vehicle dynamic simulations. Developed to fit quasi steady-state wind tunnel data, the aerodynamic model is regressed against three independent variables: front ground clearance, rear ride height, and yaw angle. An initial dual range model is presented and then further refined to reduce the model complexity while maintaining a high level of predictive accuracy. The model complexity reduction decreases the required amount of wind tunnel data thereby reducing wind tunnel testing time and cost. The quasi steady-state aerodynamic model for the pitch moment degree of freedom is systematically developed in this paper. This same procedure can be extended to the other five aerodynamic degrees of freedom to develop a complete six degree of freedom quasi steady-state aerodynamic model for any vehicle.

Technical challenges in the construction of the steady-state stellarator Wendelstein 7-X

NASA Astrophysics Data System (ADS)

Bosch, H.-S.; Wolf, R. C.; Andreeva, T.; Baldzuhn, J.; Birus, D.; Bluhm, T.; Bräuer, T.; Braune, H.; Bykov, V.; Cardella, A.; Durodié, F.; Endler, M.; Erckmann, V.; Gantenbein, G.; Hartmann, D.; Hathiramani, D.; Heimann, P.; Heinemann, B.; Hennig, C.; Hirsch, M.; Holtum, D.; Jagielski, J.; Jelonnek, J.; Kasparek, W.; Klinger, T.; König, R.; Kornejew, P.; Kroiss, H.; Krom, J. G.; Kühner, G.; Laqua, H.; Laqua, H. P.; Lechte, C.; Lewerentz, M.; Maier, J.; McNeely, P.; Messiaen, A.; Michel, G.; Ongena, J.; Peacock, A.; Pedersen, T. S.; Riedl, R.; Riemann, H.; Rong, P.; Rust, N.; Schacht, J.; Schauer, F.; Schroeder, R.; Schweer, B.; Spring, A.; Stäbler, A.; Thumm, M.; Turkin, Y.; Wegener, L.; Werner, A.; Zhang, D.; Zilker, M.; Akijama, T.; Alzbutas, R.; Ascasibar, E.; Balden, M.; Banduch, M.; Baylard, Ch.; Behr, W.; Beidler, C.; Benndorf, A.; Bergmann, T.; Biedermann, C.; Bieg, B.; Biel, W.; Borchardt, M.; Borowitz, G.; Borsuk, V.; Bozhenkov, S.; Brakel, R.; Brand, H.; Brown, T.; Brucker, B.; Burhenn, R.; Buscher, K.-P.; Caldwell-Nichols, C.; Cappa, A.; Cardella, A.; Carls, A.; Carvalho, P.; Ciupiński, Ł.; Cole, M.; Collienne, J.; Czarnecka, A.; Czymek, G.; Dammertz, G.; Dhard, C. P.; Davydenko, V. I.; Dinklage, A.; Drevlak, M.; Drotziger, S.; Dudek, A.; Dumortier, P.; Dundulis, G.; Eeten, P. v.; Egorov, K.; Estrada, T.; Faugel, H.; Fellinger, J.; Feng, Y.; Fernandes, H.; Fietz, W. H.; Figacz, W.; Fischer, F.; Fontdecaba, J.; Freund, A.; Funaba, T.; Fünfgelder, H.; Galkowski, A.; Gates, D.; Giannone, L.; García Regaña, J. M.; Geiger, J.; Geißler, S.; Greuner, H.; Grahl, M.; Groß, S.; Grosman, A.; Grote, H.; Grulke, O.; Haas, M.; Haiduk, L.; Hartfuß, H.-J.; Harris, J. H.; Haus, D.; Hein, B.; Heitzenroeder, P.; Helander, P.; Heller, R.; Hidalgo, C.; Hildebrandt, D.; Höhnle, H.; Holtz, A.; Holzhauer, E.; Holzthüm, R.; Huber, A.; Hunger, H.; Hurd, F.; Ihrke, M.; Illy, S.; Ivanov, A.; Jablonski, S.; Jaksic, N.; Jakubowski, M.; Jaspers, R.; Jensen, H.; Jenzsch, H.; Kacmarczyk, J.; Kaliatk, T.; Kallmeyer, J.; Kamionka, U.; Karaleviciu, R.; Kern, S.; Keunecke, M.; Kleiber, R.; Knauer, J.; Koch, R.; Kocsis, G.; Könies, A.; Köppen, M.; Koslowski, R.; Koshurinov, J.; Krämer-Flecken, A.; Krampitz, R.; Kravtsov, Y.; Krychowiak, M.; Krzesinski, G.; Ksiazek, I.; Kubkowska, M.; Kus, A.; Langish, S.; Laube, R.; Laux, M.; Lazerson, S.; Lennartz, M.; Li, C.; Lietzow, R.; Lohs, A.; Lorenz, A.; Louche, F.; Lubyako, L.; Lumsdaine, A.; Lyssoivan, A.; Maaßberg, H.; Marek, P.; Martens, C.; Marushchenko, N.; Mayer, M.; Mendelevitch, B.; Mertens, Ph.; Mikkelsen, D.; Mishchenko, A.; Missal, B.; Mizuuchi, T.; Modrow, H.; Mönnich, T.; Morizaki, T.; Murakami, S.; Musielok, F.; Nagel, M.; Naujoks, D.; Neilson, H.; Neubauer, O.; Neuner, U.; Nocentini, R.; Noterdaeme, J.-M.; Nührenberg, C.; Obermayer, S.; Offermanns, G.; Oosterbeek, H.; Otte, M.; Panin, A.; Pap, M.; Paquay, S.; Pasch, E.; Peng, X.; Petrov, S.; Pilopp, D.; Pirsch, H.; Plaum, B.; Pompon, F.; Povilaitis, M.; Preinhaelter, J.; Prinz, O.; Purps, F.; Rajna, T.; Récsei, S.; Reiman, A.; Reiter, D.; Remmel, J.; Renard, S.; Rhode, V.; Riemann, J.; Rimkevicius, S.; Riße, K.; Rodatos, A.; Rodin, I.; Romé, M.; Roscher, H.-J.; Rummel, K.; Rummel, Th.; Runov, A.; Ryc, L.; Sachtleben, J.; Samartsev, A.; Sanchez, M.; Sano, F.; Scarabosio, A.; Schmid, M.; Schmitz, H.; Schmitz, O.; Schneider, M.; Schneider, W.; Scheibl, L.; Scholz, M.; Schröder, G.; Schröder, M.; Schruff, J.; Schumacher, H.; Shikhovtsev, I. V.; Shoji, M.; Siegl, G.; Skodzik, J.; Smirnow, M.; Speth, E.; Spong, D. A.; Stadler, R.; Sulek, Z.; Szabó, V.; Szabolics, T.; Szetefi, T.; Szökefalvi-Nagy, Z.; Tereshchenko, A.; Thomsen, H.; Thumm, M.; Timmermann, D.; Tittes, H.; Toi, K.; Tournianski, M.; Toussaint, U. v.; Tretter, J.; Tulipán, S.; Turba, P.; Uhlemann, R.; Urban, J.; Urbonavicius, E.; Urlings, P.; Valet, S.; Van Eester, D.; Van Schoor, M.; Vervier, M.; Viebke, H.; Vilbrandt, R.; Vrancken, M.; Wauters, T.; Weissgerber, M.; Weiß, E.; Weller, A.; Wendorf, J.; Wenzel, U.; Windisch, T.; Winkler, E.; Winkler, M.; Wolowski, J.; Wolters, J.; Wrochna, G.; Xanthopoulos, P.; Yamada, H.; Yokoyama, M.; Zacharias, D.; Zajac, J.; Zangl, G.; Zarnstorff, M.; Zeplien, H.; Zoletnik, S.; Zuin, M.

2013-12-01

The next step in the Wendelstein stellarator line is the large superconducting device Wendelstein 7-X, currently under construction in Greifswald, Germany. Steady-state operation is an intrinsic feature of stellarators, and one key element of the Wendelstein 7-X mission is to demonstrate steady-state operation under plasma conditions relevant for a fusion power plant. Steady-state operation of a fusion device, on the one hand, requires the implementation of special technologies, giving rise to technical challenges during the design, fabrication and assembly of such a device. On the other hand, also the physics development of steady-state operation at high plasma performance poses a challenge and careful preparation. The electron cyclotron resonance heating system, diagnostics, experiment control and data acquisition are prepared for plasma operation lasting 30 min. This requires many new technological approaches for plasma heating and diagnostics as well as new concepts for experiment control and data acquisition.

Evaluation of Start Transient Oscillations with the J-2X Engine Gas Generator Assembly

NASA Technical Reports Server (NTRS)

Hulka, J. R.; Morgan, C. J.; Casiano, M. J.

2015-01-01

During development of the gas generator for the liquid oxygen/liquid hydrogen propellant J-2X rocket engine, distinctive and oftentimes high-amplitude pressure oscillations and hardware vibrations occurred during the start transient of nearly every workhorse gas generator assembly test, as well as during many tests of engine system hardware. These oscillations appeared whether the steady-state conditions exhibited stable behavior or not. They occurred similarly with three different injector types, and with every combustion chamber configuration tested, including chamber lengths ranging over a 5:1 range, several different nozzle types, and with or without a side branch line simulating a turbine spin start gas supply line. Generally, two sets of oscillations occurred, one earlier in the start transient and at higher frequencies, and the other almost immediately following and at lower frequencies. Multiple dynamic pressure measurements in the workhorse combustion chambers indicated that the oscillations were associated with longitudinal acoustic modes of the combustion chambers, with the earlier and higher frequency oscillation usually related to the second longitudinal acoustic mode and the later and lower frequency oscillation usually related to the first longitudinal acoustic mode. Given that several early development gas generator assemblies exhibited unstable behavior at frequencies near the first longitudinal acoustic modes of longer combustion chambers, the start transient oscillations are presumed to provide additional insight into the nature of the combustion instability mechanisms. Aspects of the steadystate oscillations and combustion instabilities from development and engine system test programs have been reported extensively in the three previous JANNAF Liquid Propulsion Subcommittee meetings (see references below). This paper describes the hardware configurations, start transient sequence operations, and transient and dynamic test data during the start transient. The implications of these results on previous analyses and understanding of the combustion instability observed during steady-state conditions, especially the effects of injector influences, is discussed.

40 CFR Appendix II to Part 1042 - Steady-State Duty Cycles

Code of Federal Regulations, 2010 CFR

2010-07-01

... 40 Protection of Environment 32 2010-07-01 2010-07-01 false Steady-State Duty Cycles II Appendix..., App. II Appendix II to Part 1042—Steady-State Duty Cycles (a) The following duty cycles apply as specified in § 1042.505(b)(1): (1) The following duty cycle applies for discrete-mode testing: E3 mode No...

Min-By-Min Respiratory Exchange and Oxygen Uptake Kinetics During Steady-State Exercise in Subjects of High and Low Max VO2

ERIC Educational Resources Information Center

Weltman, Arthur; Katch, Victor

1976-01-01

No statistically meaningful differences in steady-state vo2 uptake for high and low max vo2 groups was indicated in this study, but a clear tendency was observed for the high max vo2 group to reach the steady-state at a faster rate. (MB)

Quantitative controls on submarine slope failure morphology

USGS Publications Warehouse

Lee, H.J.; Schwab, W.C.; Edwards, B.D.; Kayen, R.E.

1991-01-01

The concept of the steady-state of deformation can be applied to predicting the ultimate form a landslide will take. The steady-state condition, defined by a line in void ratio-effective stress space, exists at large levels of strain and remolding. Conceptually, if sediment initially exists with void ratio-effective stress conditions above the steady-state line, the sediment shear strength will decrease during a transient loading event, such as an earthquake or storm. If the reduced shear strength existing at the steady state is less than the downslope shear stress induced by gravity, then large-scale internal deformation, disintegration, and flow will occur. -from Authors

Isotopic composition of transpiration and rates of change in leaf water isotopologue storage in response to environmental variables.

PubMed

Simonin, Kevin A; Roddy, Adam B; Link, Percy; Apodaca, Randy; Tu, Kevin P; Hu, Jia; Dawson, Todd E; Barbour, Margaret M

2013-12-01

During daylight hours, the isotope composition of leaf water generally approximates steady-state leaf water isotope enrichment model predictions. However, until very recently there was little direct confirmation that isotopic steady-state (ISS) transpiration in fact exists. Using isotope ratio infrared spectroscopy (IRIS) and leaf gas exchange systems we evaluated the isotope composition of transpiration and the rate of change in leaf water isotopologue storage (isostorage) when leaves were exposed to variable environments. In doing so, we developed a method for controlling the absolute humidity entering the gas exchange cuvette for a wide range of concentrations without changing the isotope composition of water vapour. The measurement system allowed estimation of (18)O enrichment both at the evaporation site and for bulk leaf water, in the steady state and the non-steady state. We show that non-steady-state effects dominate the transpiration isoflux even when leaves are at physiological steady state. Our results suggest that a variable environment likely prevents ISS transpiration from being achieved and that this effect may be exacerbated by lengthy leaf water turnover times due to high leaf water contents. © 2013 John Wiley & Sons Ltd.

Detection-enhanced steady state entanglement with ions.

PubMed

Bentley, C D B; Carvalho, A R R; Kielpinski, D; Hope, J J

2014-07-25

Driven dissipative steady state entanglement schemes take advantage of coupling to the environment to robustly prepare highly entangled states. We present a scheme for two trapped ions to generate a maximally entangled steady state with fidelity above 0.99, appropriate for use in quantum protocols. Furthermore, we extend the scheme by introducing detection of our dissipation process, significantly enhancing the fidelity. Our scheme is robust to anomalous heating and requires no sympathetic cooling.

A simple fitness proxy for structured populations with continuous traits, with case studies on the evolution of haplo-diploids and genetic dimorphisms.

PubMed

Metz, J A J; Leimar, O

2011-03-01

For structured populations in equilibrium with everybody born equal, ln(R (0)) is a useful fitness proxy for evolutionarily steady strategy (ESS) and most adaptive dynamics calculations, with R (0) the average lifetime number of offspring in the clonal and haploid cases, and half the average lifetime number of offspring fathered or mothered for Mendelian diploids. When individuals have variable birth states, as is, for example, the case in spatial models, R (0) is itself an eigenvalue, which usually cannot be expressed explicitly in the trait vectors under consideration. In that case, Q(Y| X):=-det (I-L(Y| X)) can often be used as fitness proxy, with L the next-generation matrix for a potential mutant characterized by the trait vector Y in the (constant) environment engendered by a resident characterized by X. If the trait space is connected, global uninvadability can be determined from it. Moreover, it can be used in all the usual local calculations like the determination of evolutionarily singular trait vectors and their local invadability and attractivity. We conclude with three extended case studies demonstrating the usefulness of Q: the calculation of ESSs under haplo-diploid genetics (I), of evolutionarily steady genetic dimorphisms (ESDs) with a priori proportionality of macro- and micro-gametic outputs (an assumption that is generally made but the fulfilment of which is a priori highly exceptional) (II), and of ESDs without such proportionality (III). These case studies should also have some interest in their own right for the spelled out calculation recipes and their underlying modelling methodology.

Transition from one revolving cluster to two revolving clusters in the ground-state rotational bands of nuclei in the lanthanon region.

PubMed

Pauling, L

1991-02-01

Whereas 234(92)U142 and other actinon nuclei have ground-state bands that indicate that each nucleus consists of a sphere and a single revolving cluster with constant composition and with only a steady increase in the moment of inertia with increase in J, the angular-momentum quantum number, many of the lanthanon ground-state bands show discontinuities, usually with an initial slightly or strongly curved segment followed by one or two nearly straight segments. The transition to nearly straight segments is interpreted as a change in structure from one revolving cluster to two revolving clusters. The proton-neutron compositions of the clusters and the central sphere are assigned, leading to values of the radius of revolution. The approximation of the two-cluster sequences to linearity is attributed to the very small values of the quadrupole polarizability of the central sphere. Values of the nucleon numbers of clusters and spheres, of the radius of revolution, and of promotion energy are discussed.

Steady-state MR imaging sequences: physics, classification, and clinical applications.

PubMed

Chavhan, Govind B; Babyn, Paul S; Jankharia, Bhavin G; Cheng, Hai-Ling M; Shroff, Manohar M

2008-01-01

Steady-state sequences are a class of rapid magnetic resonance (MR) imaging techniques based on fast gradient-echo acquisitions in which both longitudinal magnetization (LM) and transverse magnetization (TM) are kept constant. Both LM and TM reach a nonzero steady state through the use of a repetition time that is shorter than the T2 relaxation time of tissue. When TM is maintained as multiple radiofrequency excitation pulses are applied, two types of signal are formed once steady state is reached: preexcitation signal (S-) from echo reformation; and postexcitation signal (S+), which consists of free induction decay. Depending on the signal sampled and used to form an image, steady-state sequences can be classified as (a) postexcitation refocused (only S+ is sampled), (b) preexcitation refocused (only S- is sampled), and (c) fully refocused (both S+ and S- are sampled) sequences. All tissues with a reasonably long T2 relaxation time will show additional signals due to various refocused echo paths. Steady-state sequences have revolutionized cardiac imaging and have become the standard for anatomic functional cardiac imaging and for the assessment of myocardial viability because of their good signal-to-noise ratio and contrast-to-noise ratio and increased speed of acquisition. They are also useful in abdominal and fetal imaging and hold promise for interventional MR imaging. Because steady-state sequences are now commonly used in MR imaging, radiologists will benefit from understanding the underlying physics, classification, and clinical applications of these sequences.

Time density curve analysis for C-arm FDCT PBV imaging

PubMed Central

Byrne, James V

2016-01-01

Introduction Parenchymal blood volume (PBV) estimation using C-arm flat detector computed tomography (FDCT) assumes a steady-state contrast concentration in cerebral vasculature for the scan duration. Using time density curve (TDC) analysis, we explored if the steady-state assumption is met for C-arm CT PBV scans, and how consistent the contrast-material dynamics in cerebral vasculature are across patients. Methods Thirty C-arm FDCT datasets of 26 patients with aneurysmal-SAH, acquired as part of a prospective study comparing C-arm CT PBV with MR-PWI, were analysed. TDCs were extracted from the 2D rotational projections. Goodness-of-fit of TDCs to a steady-state horizontal-line-model and the statistical similarity among the individual TDCs were tested. Influence of the differences in TDC characteristics on the agreement of resulting PBV measurements with MR-CBV was calculated. Results Despite identical scan parameters and contrast-injection-protocol, the individual TDCs were statistically non-identical (p < 0.01). Using Dunn's multiple comparisons test, of the total 435 individual comparisons among the 30 TDCs, 330 comparisons (62%) reached statistical significance for difference. All TDCs deviated significantly (p < 0.01) from the steady-state horizontal-line-model. PBV values of those datasets for which the TDCs showed largest deviations from the steady-state model demonstrated poor agreement and correlation with MR-CBV, compared with the PBV values of those datasets for which the TDCs were closer to steady-state. Conclusion For clinical C-arm CT PBV examinations, the administered contrast material does not reach the assumed ‘ideal steady-state’ for the duration of scan. Using a prolonged injection protocol, the degree to which the TDCs approximate the ideal steady-state influences the agreement of resulting PBV measurements with MR-CBV. PMID:26769736

The effect of shot noise on the start up of the fundamental and harmonics in free-electron lasers

DOE Office of Scientific and Technical Information (OSTI.GOV)

Freund, H. P.; Miner, W. H. Jr.; Giannessi, L.

2008-12-15

The problem of radiation start up in free-electron lasers (FELs) is important in the simulation of virtually all FEL configurations including oscillators and amplifiers in both seeded master oscillator power amplifier (MOPA) and self-amplified spontaneous emission (SASE) modes. Both oscillators and SASE FELs start up from spontaneous emission due to shot noise on the electron beam, which arises from the random fluctuations in the phase distribution of the electrons. The injected power in a MOPA is usually large enough to overwhelm the shot noise. However, this noise must be treated correctly in order to model the initial start up ofmore » the harmonics. In this paper, we discuss and compare two different shot noise models that are implemented in both one-dimensional wiggler-averaged (PERSEO) and non-wiggler-averaged (MEDUSA1D) simulation codes, and a three-dimensional non-wiggler-averaged (MEDUSA) formulation. These models are compared for examples describing both SASE and MOPA configurations in one dimension, in steady-state, and time-dependent simulations. Remarkable agreement is found between PERSEO and MEDUSA1D for the evolution of the fundamental and harmonics. In addition, three-dimensional correction factors have been included in the MEDUSA1D and PERSEO, which show reasonable agreement with MEDUSA for a sample MOPA in steady-state and time-dependent simulations.« less

Transport and sources of sediment in the Missouri River between Garrison Dam and the headwaters of Lake Oahe, North Dakota, May 1988 through April 1991

USGS Publications Warehouse

Berkas, Wayne R.

1995-01-01

Sediment data were collected on and along the Missouri River downstream from Garrison Dam during May 1988, May 1989, and April 1991 to characterize sediment transport in the river. Specific study objectives were to (1) identify erosional and depositional reaches during two steady-state low-flow periods and one steady-state high-flow period; (2) determine if the reaches are consistently eroding or depositing, regardless of streamflow; and (3) determine the sources of suspended sediment in the river. Erosional and depositional reaches differed between the two low-flow periods, indicating that slight changes in the channel configuration between the two periods caused changes in erosional and depositional patterns. Erosional and depositional reaches also differed between the low-flow periods and the high-flow period, indicating that channel changes and increased streamflow velocities affect erosional and depositional reaches. The significant sources of suspended sediment in the Missouri River are the riverbed and riverbanks. The riverbed contributes to the silt and sand load in the river, and the riverbanks contribute to the clay, silt, and sand load. The contribution from tributaries to the suspendedsediment load in the Missouri River usually is small. Occasionally, during low-flow periods on the Missouri River, the Knife River can contribute significantly to the suspended-sediment load in the Missouri River.

Studying Biological Rhythms of Person's Skin-galvanic Reaction and Dynamics of Light Transmission by Isomeric Substance in Space Flight Conditions

NASA Technical Reports Server (NTRS)

Glushko, Vladimir

2004-01-01

Intensity and amplitude of human functional systems and human most important organs are wavelike, rhythmic by nature. These waves have constant periodicity, phase and amplitude. The mentioned characteristics can vary, however their variations have a pronounced reiteration in the course of time. This indicates a hashing of several wave processes and their interference. Stochastic changes in wave processes characteristics of a human organism are explained either by 'pulsations' associated with hashing (superposition) of several wave processes and their interference, or by single influence of environmental physical factors on a human organism. Human beings have respectively periods of higher and lower efficiency, state of health and so on, depending not only of environmental factors, but also of 'internal' rhythmic factor. Sometimes peaks and falls periodicity of some or other characteristics is broken. Disturbance of steady-state biological rhythms is usually accompanied by reduction of activity steadiness of the most important systems of a human organism. In its turn this has an effect on organism's adaptation to changing living conditions as well as on general condition and efficiency of a human being. The latter factor is very important for space medicine. Biological rhythmology is a special branch of biology and medicine, it studies rhythmic activity mechanisms of organs, their systems, individuals and species. Appropriate researches were also carried out in space medicine.

Pressure Distribution and Performance Impacts of Aerospike Nozzles on Rotating Detonation Engines

DTIC Science & Technology

2017-06-01

design methodology at both on- and off-design conditions anticipated throughout the combustion cycle. Steady-state, non -reacting computational fluid...operation. Therefore, the nozzle contour was designed using a traditional, steady-state design methodology at both on- and off-design conditions...anticipated throughout the combustion cycle. Steady-state, non -reacting computational fluid dynamics (CFD) simulations were performed on various nozzle

Universal, computer facilitated, steady state oscillator, closed loop analysis theory and some applications to precision oscillators

NASA Technical Reports Server (NTRS)

Parzen, Benjamin

1992-01-01

The theory of oscillator analysis in the immittance domain should be read in conjunction with the additional theory presented here. The combined theory enables the computer simulation of the steady state oscillator. The simulation makes the calculation of the oscillator total steady state performance practical, including noise at all oscillator locations. Some specific precision oscillators are analyzed.

Steady state analysis of Boolean molecular network models via model reduction and computational algebra.

PubMed

Veliz-Cuba, Alan; Aguilar, Boris; Hinkelmann, Franziska; Laubenbacher, Reinhard

2014-06-26

A key problem in the analysis of mathematical models of molecular networks is the determination of their steady states. The present paper addresses this problem for Boolean network models, an increasingly popular modeling paradigm for networks lacking detailed kinetic information. For small models, the problem can be solved by exhaustive enumeration of all state transitions. But for larger models this is not feasible, since the size of the phase space grows exponentially with the dimension of the network. The dimension of published models is growing to over 100, so that efficient methods for steady state determination are essential. Several methods have been proposed for large networks, some of them heuristic. While these methods represent a substantial improvement in scalability over exhaustive enumeration, the problem for large networks is still unsolved in general. This paper presents an algorithm that consists of two main parts. The first is a graph theoretic reduction of the wiring diagram of the network, while preserving all information about steady states. The second part formulates the determination of all steady states of a Boolean network as a problem of finding all solutions to a system of polynomial equations over the finite number system with two elements. This problem can be solved with existing computer algebra software. This algorithm compares favorably with several existing algorithms for steady state determination. One advantage is that it is not heuristic or reliant on sampling, but rather determines algorithmically and exactly all steady states of a Boolean network. The code for the algorithm, as well as the test suite of benchmark networks, is available upon request from the corresponding author. The algorithm presented in this paper reliably determines all steady states of sparse Boolean networks with up to 1000 nodes. The algorithm is effective at analyzing virtually all published models even those of moderate connectivity. The problem for large Boolean networks with high average connectivity remains an open problem.

Steady state analysis of Boolean molecular network models via model reduction and computational algebra

PubMed Central

2014-01-01

Background A key problem in the analysis of mathematical models of molecular networks is the determination of their steady states. The present paper addresses this problem for Boolean network models, an increasingly popular modeling paradigm for networks lacking detailed kinetic information. For small models, the problem can be solved by exhaustive enumeration of all state transitions. But for larger models this is not feasible, since the size of the phase space grows exponentially with the dimension of the network. The dimension of published models is growing to over 100, so that efficient methods for steady state determination are essential. Several methods have been proposed for large networks, some of them heuristic. While these methods represent a substantial improvement in scalability over exhaustive enumeration, the problem for large networks is still unsolved in general. Results This paper presents an algorithm that consists of two main parts. The first is a graph theoretic reduction of the wiring diagram of the network, while preserving all information about steady states. The second part formulates the determination of all steady states of a Boolean network as a problem of finding all solutions to a system of polynomial equations over the finite number system with two elements. This problem can be solved with existing computer algebra software. This algorithm compares favorably with several existing algorithms for steady state determination. One advantage is that it is not heuristic or reliant on sampling, but rather determines algorithmically and exactly all steady states of a Boolean network. The code for the algorithm, as well as the test suite of benchmark networks, is available upon request from the corresponding author. Conclusions The algorithm presented in this paper reliably determines all steady states of sparse Boolean networks with up to 1000 nodes. The algorithm is effective at analyzing virtually all published models even those of moderate connectivity. The problem for large Boolean networks with high average connectivity remains an open problem. PMID:24965213

Dynamics of Rear Stagnant Cap formation at the surface of spherical bubbles rising in surfactant solutions at large Reynolds numbers under conditions of small Marangoni number and slow sorption kinetics.

PubMed

Dukhin, S S; Kovalchuk, V I; Gochev, G G; Lotfi, M; Krzan, M; Malysa, K; Miller, R

2015-08-01

On the surface of bubbles rising in a surfactant solution the adsorption process proceeds and leads to the formation of a so called Rear Stagnant Cap (RSC). The larger this RSC is the stronger is the retardation of the rising velocity. The theory of a steady RSC and steady retarded rising velocity, which sets in after a transient stage, has been generally accepted. However, a non-steady process of bubble rising starting from the initial zero velocity represents an important portion of the trajectory of rising, characterized by a local velocity profile (LVP). As there is no theory of RSC growth for large Reynolds numbers Re » 1 so far, the interpretation of LVPs measured in this regime was impossible. It turned out, that an analytical theory for a quasi-steady growth of RSC is possible for small Marangoni numbers Ma « 1, i.e. when the RSC is almost completely compressed, which means a uniform surface concentration Γ(θ)=Γ(∞) within the RSC. Hence, the RSC angle ψ(t) is obtained as a function of the adsorption isotherm parameters and time t. From the steady velocity v(st)(ψ), the dependence of non-steady velocity on time is obtained by employing v(st)[ψ(t)] via a quasi-steady approximation. The measurement of LVP creates a promising new opportunity for investigation of the RSC dynamics and adsorption kinetics. While adsorption and desorption happen at the same localization in the classical methods, in rising bubble experiments desorption occurs mainly within RSC while adsorption on the mobile part of the bubble surface. The desorption flux from RSC is proportional to αΓ(∞), while it is usually αΓ. The adsorption flux at the mobile surface above RSC can be assumed proportional to βC0, while it is usually βC0(1-Γ/Γ(∞)). These simplifications may become favorable in investigations of the adsorption kinetics for larger molecules, in particular for globular proteins, which essentially stay at an interface once adsorbed. Copyright © 2014 Elsevier B.V. All rights reserved.

Transitions between strongly correlated and random steady-states for catalytic CO-oxidation on surfaces at high-pressure

DOE PAGES

Liu, Da -Jiang; Evans, James W.

2015-04-02

We explore simple lattice-gas reaction models for CO-oxidation on 1D and 2D periodic arrays of surface adsorption sites. The models are motivated by studies of CO-oxidation on RuO 2(110) at high-pressures. Although adspecies interactions are neglected, the effective absence of adspecies diffusion results in kinetically-induced spatial correlations. A transition occurs from a random mainly CO-populated steady-state at high CO-partial pressure p CO, to a strongly-correlated near-O-covered steady-state for low p CO as noted. In addition, we identify a second transition to a random near-O-covered steady-state at very low p CO.

The steady-state visual evoked potential in vision research: A review

PubMed Central

Norcia, Anthony M.; Appelbaum, L. Gregory; Ales, Justin M.; Cottereau, Benoit R.; Rossion, Bruno

2015-01-01

Periodic visual stimulation and analysis of the resulting steady-state visual evoked potentials were first introduced over 80 years ago as a means to study visual sensation and perception. From the first single-channel recording of responses to modulated light to the present use of sophisticated digital displays composed of complex visual stimuli and high-density recording arrays, steady-state methods have been applied in a broad range of scientific and applied settings.The purpose of this article is to describe the fundamental stimulation paradigms for steady-state visual evoked potentials and to illustrate these principles through research findings across a range of applications in vision science. PMID:26024451

Symmetry limit theory for cantilever beam-columns subjected to cyclic reversed bending

NASA Astrophysics Data System (ADS)

Uetani, K.; Nakamura, Tsuneyoshi

THE BEHAVIOR of a linear strain-hardening cantilever beam-column subjected to completely reversed plastic bending of a new idealized program under constant axial compression consists of three stages: a sequence of symmetric steady states, a subsequent sequence of asymmetric steady states and a divergent behavior involving unbounded growth of an anti-symmetric deflection mode. A new concept "symmetry limit" is introduced here as the smallest critical value of the tip-deflection amplitude at which transition from a symmetric steady state to an asymmetric steady state can occur in the response of a beam-column. A new theory is presented for predicting the symmetry limits. Although this transition phenomenon is phenomenologically and conceptually different from the branching phenomenon on an equilibrium path, it is shown that a symmetry limit may theoretically be regarded as a branching point on a "steady-state path" defined anew. The symmetry limit theory and the fundamental hypotheses are verified through numerical analysis of hysteretic responses of discretized beam-column models.

A general theory of kinetics and thermodynamics of steady-state copolymerization.

PubMed

Shu, Yao-Gen; Song, Yong-Shun; Ou-Yang, Zhong-Can; Li, Ming

2015-06-17

Kinetics of steady-state copolymerization has been investigated since the 1940s. Irreversible terminal and penultimate models were successfully applied to a number of comonomer systems, but failed for systems where depropagation is significant. Although a general mathematical treatment of the terminal model with depropagation was established in the 1980s, a penultimate model and higher-order terminal models with depropagation have not been systematically studied, since depropagation leads to hierarchically-coupled and unclosed kinetic equations which are hard to solve analytically. In this work, we propose a truncation method to solve the steady-state kinetic equations of any-order terminal models with depropagation in a unified way, by reducing them into closed steady-state equations which give the exact solution of the original kinetic equations. Based on the steady-state equations, we also derive a general thermodynamic equality in which the Shannon entropy of the copolymer sequence is explicitly introduced as part of the free energy dissipation of the whole copolymerization system.

Molecular control of steady-state dendritic cell maturation and immune homeostasis.

PubMed

Hammer, Gianna Elena; Ma, Averil

2013-01-01

Dendritic cells (DCs) are specialized sentinels responsible for coordinating adaptive immunity. This function is dependent upon coupled sensitivity to environmental signs of inflammation and infection to cellular maturation-the programmed alteration of DC phenotype and function to enhance immune cell activation. Although DCs are thus well equipped to respond to pathogens, maturation triggers are not unique to infection. Given that immune cells are exquisitely sensitive to the biological functions of DCs, we now appreciate that multiple layers of suppression are required to restrict the environmental sensitivity, cellular maturation, and even life span of DCs to prevent aberrant immune activation during the steady state. At the same time, steady-state DCs are not quiescent but rather perform key functions that support homeostasis of numerous cell types. Here we review these functions and molecular mechanisms of suppression that control steady-state DC maturation. Corruption of these steady-state operatives has diverse immunological consequences and pinpoints DCs as potent drivers of autoimmune and inflammatory disease.

Lineage tracing of murine adult hematopoietic stem cells reveals active contribution to steady-state hematopoiesis

PubMed Central

Chapple, Richard H.; Tseng, Yu-Jung; Hu, Tianyuan; Kitano, Ayumi; Takeichi, Makiko; Hoegenauer, Kevin A.

2018-01-01

Characterization of hematopoietic stem cells (HSCs) has advanced largely owing to transplantation assays, in which the developmental potential of HSCs is assessed generally in nonhomeostatic conditions. These studies established that adult HSCs extensively contribute to multilineage hematopoietic regeneration upon transplantation. On the contrary, recent studies performing lineage tracing of HSCs under homeostatic conditions have shown that adult HSCs may contribute far less to steady-state hematopoiesis than would be anticipated based on transplantation assays. Here, we used 2 independent HSC-lineage–tracing models to examine the contribution of adult HSCs to steady-state hematopoiesis. We show that adult HSCs contribute robustly to steady-state hematopoiesis, exhibiting faster efflux toward the myeloid lineages compared with lymphoid lineages. Platelets were robustly labeled by HSCs, reaching the same level of labeling as HSCs by 1 year of chase. Our results support the view that adult HSCs contribute to the continuous influx of blood cells during steady-state hematopoiesis. PMID:29848758

Steady State Condition in the Measurement of VO2and VCO2by Indirect Calorimetry.

PubMed

Cadena, M; Sacristan, E; Infante, O; Escalante, B; Rodriguez, F

2005-01-01

Resting Metabolic Rate (RMR) is computed using VO2and VCO2short time 15-minute window measurement with Indirect Calorimetry (IC) instruments designed with mixing chamber. Steady state condition using a 10% variation coefficient criteria is the main objective to achieve metabolic long time prediction reliability. This study address how susceptible is the steady state VO2, VCO2measurement condition to the clino-orthostatic physiological maneuver. 30 young healthy subjects were analyzed. Only 18 passed the 10% variation coefficient inclusive criteria. They were exposed to 10 minutes clino-stage and 10 minutes orthostage. The hypothesis tests show not statistical significance (p< 0.1) in the average and variance analysis. It is concluded that the steady state is not influenced by the patient position IC test, probably because IC mixing chamber instruments are insensitive to detect a mayor physiological dynamics changes that can modify the steady state definition.

Einstein's steady-state theory: an abandoned model of the cosmos

NASA Astrophysics Data System (ADS)

O'Raifeartaigh, Cormac; McCann, Brendan; Nahm, Werner; Mitton, Simon

2014-09-01

We present a translation and analysis of an unpublished manuscript by Albert Einstein in which he attempted to construct a `steady-state' model of the universe. The manuscript, which appears to have been written in early 1931, demonstrates that Einstein once explored a cosmic model in which the mean density of matter in an expanding universe is maintained constant by the continuous formation of matter from empty space. This model is very different to previously known Einsteinian models of the cosmos (both static and dynamic) but anticipates the later steady-state cosmology of Hoyle, Bondi and Gold in some ways. We find that Einstein's steady-state model contains a fundamental flaw and suggest that it was abandoned for this reason. We also suggest that he declined to explore a more sophisticated version because he found such theories rather contrived. The manuscript is of historical interest because it reveals that Einstein debated between steady-state and evolving models of the cosmos decades before a similar debate took place in the cosmological community.

Radiative transport equation for the Mittag-Leffler path length distribution

NASA Astrophysics Data System (ADS)

Liemert, André; Kienle, Alwin

2017-05-01

In this paper, we consider the radiative transport equation for infinitely extended scattering media that are characterized by the Mittag-Leffler path length distribution p (ℓ ) =-∂ℓEα(-σtℓα ) , which is a generalization of the usually assumed Lambert-Beer law p (ℓ ) =σtexp(-σtℓ ) . In this context, we derive the infinite-space Green's function of the underlying fractional transport equation for the spherically symmetric medium as well as for the one-dimensional string. Moreover, simple analytical solutions are presented for the prediction of the radiation field in the single-scattering approximation. The resulting equations are compared with Monte Carlo simulations in the steady-state and time domain showing, within the stochastic nature of the simulations, an excellent agreement.

A Poisson-like closed-form expression for the steady-state wealth distribution in a kinetic model of gambling

NASA Astrophysics Data System (ADS)

Garcia, Jane Bernadette Denise M.; Esguerra, Jose Perico H.

2017-08-01

An approximate but closed-form expression for a Poisson-like steady state wealth distribution in a kinetic model of gambling was formulated from a finite number of its moments, which were generated from a βa,b(x) exchange distribution. The obtained steady-state wealth distributions have tails which are qualitatively similar to those observed in actual wealth distributions.

The relationship between skin aging and steady state ultraweak photon emission as an indicator of skin oxidative stress in vivo.

PubMed

Gabe, Y; Osanai, O; Takema, Y

2014-08-01

Ultraweak photon emission (UPE) is one potential method to evaluate the oxidative status of the skin in vivo. However, little is known about how the daily oxidative stress of the skin is related to skin aging-related alterations in vivo. We characterized the steady state UPE and performed a skin survey. We evaluated the skin oxidative status by UPE, skin elasticity, epidermal thickness and skin color on the inner upper arm, the outer forearm, and the buttock of 70 Japanese volunteers. The steady state UPE at the three skin sites increased with age. Correlation analysis revealed that the steady state UPE only from the buttock was related to skin elasticity, which showed age-dependent changes. Moreover, analysis by age group indicated that b* values of the inner upper arm of subjects in their 20s were inversely correlated with UPE as occurred in buttock skin. In contrast, photoaged skin did not show a clear relationship with steady state UPE because the accumulation of sun-exposure might influence the sensitivity to oxidative stress. These results suggest that steady state UPE reflects not only intrinsic skin aging and cutaneous color but also the current oxidative status independent of skin aging. © 2013 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

Perception of steady-state vowels and vowelless syllables by adults and children

NASA Astrophysics Data System (ADS)

Nittrouer, Susan

2005-04-01

Vowels can be produced as long, isolated, and steady-state, but that is not how they are found in natural speech. Instead natural speech consists of almost continuously changing (i.e., dynamic) acoustic forms from which mature listeners recover underlying phonetic form. Some theories suggest that children need steady-state information to recognize vowels (and so learn vowel systems), even though that information is sparse in natural speech. The current study examined whether young children can recover vowel targets from dynamic forms, or whether they need steady-state information. Vowel recognition was measured for adults and children (3, 5, and 7 years) for natural productions of /dæd/, /dUd/ /æ/, /U/ edited to make six stimulus sets: three dynamic (whole syllables; syllables with middle 50-percent replaced by cough; syllables with all but the first and last three pitch periods replaced by cough), and three steady-state (natural, isolated vowels; reiterated pitch periods from those vowels; reiterated pitch periods from the syllables). Adults scored nearly perfectly on all but first/last three pitch period stimuli. Children performed nearly perfectly only when the entire syllable was heard, and performed similarly (near 80%) for all other stimuli. Consequently, children need dynamic forms to perceive vowels; steady-state forms are not preferred.

A stability analysis of the power-law steady state of marine size spectra.

PubMed

Datta, Samik; Delius, Gustav W; Law, Richard; Plank, Michael J

2011-10-01

This paper investigates the stability of the power-law steady state often observed in marine ecosystems. Three dynamical systems are considered, describing the abundance of organisms as a function of body mass and time: a "jump-growth" equation, a first order approximation which is the widely used McKendrick-von Foerster equation, and a second order approximation which is the McKendrick-von Foerster equation with a diffusion term. All of these yield a power-law steady state. We derive, for the first time, the eigenvalue spectrum for the linearised evolution operator, under certain constraints on the parameters. This provides new knowledge of the stability properties of the power-law steady state. It is shown analytically that the steady state of the McKendrick-von Foerster equation without the diffusion term is always unstable. Furthermore, numerical plots show that eigenvalue spectra of the McKendrick-von Foerster equation with diffusion give a good approximation to those of the jump-growth equation. The steady state is more likely to be stable with a low preferred predator:prey mass ratio, a large diet breadth and a high feeding efficiency. The effects of demographic stochasticity are also investigated and it is concluded that these are likely to be small in real systems.

EEMD-Based Steady-State Indexes and Their Applications to Condition Monitoring and Fault Diagnosis of Railway Axle Bearings

PubMed Central

Fan, Wei; Tsui, Kwok-Leung; Lin, Jianhui

2018-01-01

Railway axle bearings are one of the most important components used in vehicles and their failures probably result in unexpected accidents and economic losses. To realize a condition monitoring and fault diagnosis scheme of railway axle bearings, three dimensionless steadiness indexes in a time domain, a frequency domain, and a shape domain are respectively proposed to measure the steady states of bearing vibration signals. Firstly, vibration data collected from some designed experiments are pre-processed by using ensemble empirical mode decomposition (EEMD). Then, the coefficient of variation is introduced to construct two steady-state indexes from pre-processed vibration data in a time domain and a frequency domain, respectively. A shape function is used to construct a steady-state index in a shape domain. At last, to distinguish normal and abnormal bearing health states, some guideline thresholds are proposed. Further, to identify axle bearings with outer race defects, a pin roller defect, a cage defect, and coupling defects, the boundaries of all steadiness indexes are experimentally established. Experimental results showed that the proposed condition monitoring and fault diagnosis scheme is effective in identifying different bearing health conditions. PMID:29495446

Bipolar pulse field for magnetic refrigeration

DOEpatents

Lubell, Martin S.

1994-01-01

A magnetic refrigeration apparatus includes first and second steady state magnets, each having a field of substantially equal strength and opposite polarity, first and second bodies made of magnetocaloric material disposed respectively in the influence of the fields of the first and second steady state magnets, and a pulsed magnet, concentric with the first and second steady state magnets, and having a field which cycles between the fields of the first and second steady state magnets, thereby cyclically magnetizing and demagnetizing and thus heating and cooling the first and second bodies. Heat exchange apparatus of suitable design can be used to expose a working fluid to the first and second bodies of magnetocaloric material. A controller is provided to synchronize the flow of working fluid with the changing states of magnetization of the first and second bodies.

Steady State Advanced Tokamak (SSAT): The mission and the machine

NASA Astrophysics Data System (ADS)

Thomassen, K.; Goldston, R.; Nevins, B.; Neilson, H.; Shannon, T.; Montgomery, B.

1992-03-01

Extending the tokamak concept to the steady state regime and pursuing advances in tokamak physics are important and complementary steps for the magnetic fusion energy program. The required transition away from inductive current drive will provide exciting opportunities for advances in tokamak physics, as well as important impetus to drive advances in fusion technology. Recognizing this, the Fusion Policy Advisory Committee and the U.S. National Energy Strategy identified the development of steady state tokamak physics and technology, and improvements in the tokamak concept, as vital elements in the magnetic fusion energy development plan. Both called for the construction of a steady state tokamak facility to address these plan elements. Advances in physics that produce better confinement and higher pressure limits are required for a similar unit size reactor. Regimes with largely self-driven plasma current are required to permit a steady-state tokamak reactor with acceptable recirculating power. Reliable techniques of disruption control will be needed to achieve the availability goals of an economic reactor. Thus the central role of this new tokamak facility is to point the way to a more attractive demonstration reactor (DEMO) than the present data base would support. To meet the challenges, we propose a new 'Steady State Advanced Tokamak' (SSAT) facility that would develop and demonstrate optimized steady state tokamak operating mode. While other tokamaks in the world program employ superconducting toroidal field coils, SSAT would be the first major tokamak to operate with a fully superconducting coil set in the elongated, divertor geometry planned for ITER and DEMO.

Is steady-state capitalism viable? A review of the issues and an answer in the affirmative.

PubMed

Lawn, Philip

2011-02-01

Most ecological economists believe that the transition to a steady-state economy is necessary to ensure ecological sustainability and to maximize a nation's economic welfare. While some observers agree with the necessity of the steady-state economy, they are nonetheless critical of the suggestion made by ecological economists-in particular, Herman Daly-that a steady-state economy is compatible with a capitalist system. First, they believe that steady-state capitalism is based on the untenable assumption that growth is an optional rather than in-built element of capitalism. Second, they argue that capitalist notions of efficient resource allocation are too restrictive to facilitate the transition to an "ecological" or steady-state economy. I believe these observers are outright wrong with their first criticism and, because they misunderstand Daly's vision of a steady-state economy, are misplaced with their second criticism. The nature of a capitalist system depends upon the institutional framework that supports and shapes it. Hence, a capitalist system can exist in a wide variety of forms. Unfortunately, many observers fail to recognize that the current "growth imperative" is the result of capitalist systems everywhere being institutionally designed to grow. They need not be designed this way to survive and thrive. Indeed, because continued growth is both existentially undesirable and ecologically unsustainable, redesigning capitalist systems through the introduction of Daly-like institutions would prove to be capitalism's savior. What's more, it would constitute humankind's best hope of achieving sustainable development. © 2011 New York Academy of Sciences.

Quantum Dots' Photo-luminescence Line Shape Modeling

NASA Astrophysics Data System (ADS)

Hua, Muchuan; Decca, Ricardo

Two usual phenomena observed in quantum dots (QDs) photo-luminescence (PL) spectra are line broadening and energy shift between absorption and emission peaks. They have been attributed to electron-phonon coupling and surface trapping during the PL process. Although many qualitative work describing these phenomena has been carried out, quantitative results are far less common. In this work, a semi-empirical model is introduced to simulate steady state QDs' PL processes at room temperature. It was assumed that the vast majority of radiative recombination happens from surface trapped states. Consequently, the PL line shape should be highly modulated by transition rates between states in the conduction band and between them and surface trapping states. CdSe/ZnS (core/shell) colloidal QD samples with different sizes were used to examine the model. The model was able to successfully reproduce the PL spectra of these samples even when the excitation happens within the emission spectra, giving raise to up-conversion events. This model might help understand and make more precise predictions of QDs' PL spectra and could also aid on the design of QDs' optical devices.

Understanding emotional transitions: the interpersonal consequences of changing emotions in negotiations.

PubMed

Filipowicz, Allan; Barsade, Sigal; Melwani, Shimul

2011-09-01

Research on the interpersonal functions of emotions has focused primarily on steady-state emotion rather than on emotional transitions, the movement between emotion states. The authors examined the influence of emotional transitions on social interactions and found that emotional transitions led to consistently different outcomes than their corresponding steady-state emotions. Across 2 computer-mediated negotiations and a face-to-face negotiation, participants negotiating with partners who displayed a "becoming angry" (happy to angry) emotional transition accepted worse negotiation outcomes yet formed better relational impressions of their partners than participants negotiating with partners who displayed steady-state anger. This relationship was mediated through 2 mechanisms: attributional and emotional contagion processes. The "becoming happy" (angry to happy) emotional transition as compared with steady-state happiness was not significantly related to differences in negotiation outcomes but was significantly related to differences in relational impressions, where perceivers of the "becoming happy" emotional transition gave their partners lower relational impression ratings than perceivers of steady-state happiness. PsycINFO Database Record (c) 2011 APA, all rights reserved.

Quantized transport and steady states of Floquet topological insulators

NASA Astrophysics Data System (ADS)

Esin, Iliya; Rudner, Mark S.; Refael, Gil; Lindner, Netanel H.

2018-06-01

Robust electronic edge or surface modes play key roles in the fascinating quantized responses exhibited by topological materials. Even in trivial materials, topological bands and edge states can be induced dynamically by a time-periodic drive. Such Floquet topological insulators (FTIs) inherently exist out of equilibrium; the extent to which they can host quantized transport, which depends on the steady-state population of their dynamically induced edge states, remains a crucial question. In this work, we obtain the steady states of two-dimensional FTIs in the presence of the natural dissipation mechanisms present in solid state systems. We give conditions under which the steady-state distribution resembles that of a topological insulator in the Floquet basis. In this state, the distribution in the Floquet edge modes exhibits a sharp feature akin to a Fermi level, while the bulk hosts a small density of excitations. We determine the regimes where topological edge-state transport persists and can be observed in FTIs.

Human neuromagnetic steady-state responses to amplitude-modulated tones, speech, and music.

PubMed

Lamminmäki, Satu; Parkkonen, Lauri; Hari, Riitta

2014-01-01

Auditory steady-state responses that can be elicited by various periodic sounds inform about subcortical and early cortical auditory processing. Steady-state responses to amplitude-modulated pure tones have been used to scrutinize binaural interaction by frequency-tagging the two ears' inputs at different frequencies. Unlike pure tones, speech and music are physically very complex, as they include many frequency components, pauses, and large temporal variations. To examine the utility of magnetoencephalographic (MEG) steady-state fields (SSFs) in the study of early cortical processing of complex natural sounds, the authors tested the extent to which amplitude-modulated speech and music can elicit reliable SSFs. MEG responses were recorded to 90-s-long binaural tones, speech, and music, amplitude-modulated at 41.1 Hz at four different depths (25, 50, 75, and 100%). The subjects were 11 healthy, normal-hearing adults. MEG signals were averaged in phase with the modulation frequency, and the sources of the resulting SSFs were modeled by current dipoles. After the MEG recording, intelligibility of the speech, musical quality of the music stimuli, naturalness of music and speech stimuli, and the perceived deterioration caused by the modulation were evaluated on visual analog scales. The perceived quality of the stimuli decreased as a function of increasing modulation depth, more strongly for music than speech; yet, all subjects considered the speech intelligible even at the 100% modulation. SSFs were the strongest to tones and the weakest to speech stimuli; the amplitudes increased with increasing modulation depth for all stimuli. SSFs to tones were reliably detectable at all modulation depths (in all subjects in the right hemisphere, in 9 subjects in the left hemisphere) and to music stimuli at 50 to 100% depths, whereas speech usually elicited clear SSFs only at 100% depth.The hemispheric balance of SSFs was toward the right hemisphere for tones and speech, whereas SSFs to music showed no lateralization. In addition, the right lateralization of SSFs to the speech stimuli decreased with decreasing modulation depth. The results showed that SSFs can be reliably measured to amplitude-modulated natural sounds, with slightly different hemispheric lateralization for different carrier sounds. With speech stimuli, modulation at 100% depth is required, whereas for music the 75% or even 50% modulation depths provide a reasonable compromise between the signal-to-noise ratio of SSFs and sound quality or perceptual requirements. SSF recordings thus seem feasible for assessing the early cortical processing of natural sounds.

Spurious Numerical Solutions Of Differential Equations

NASA Technical Reports Server (NTRS)

Lafon, A.; Yee, H. C.

1995-01-01

Paper presents detailed study of spurious steady-state numerical solutions of differential equations that contain nonlinear source terms. Main objectives of this study are (1) to investigate how well numerical steady-state solutions of model nonlinear reaction/convection boundary-value problem mimic true steady-state solutions and (2) to relate findings of this investigation to implications for interpretation of numerical results from computational-fluid-dynamics algorithms and computer codes used to simulate reacting flows.

Electronic transport characterization of silicon wafers by spatially resolved steady-state photocarrier radiometric imaging

DOE Office of Scientific and Technical Information (OSTI.GOV)

Wang, Qian; University of the Chinese Academy of Sciences, Beijing 100039; Li, Bincheng, E-mail: bcli@ioe.ac.cn

2015-09-28

Spatially resolved steady-state photocarrier radiometric (PCR) imaging technique is developed to characterize the electronic transport properties of silicon wafers. Based on a nonlinear PCR theory, simulations are performed to investigate the effects of electronic transport parameters (the carrier lifetime, the carrier diffusion coefficient, and the front surface recombination velocity) on the steady-state PCR intensity profiles. The electronic transport parameters of an n-type silicon wafer are simultaneously determined by fitting the measured steady-state PCR intensity profiles to the three-dimensional nonlinear PCR model. The determined transport parameters are in good agreement with the results obtained by the conventional modulated PCR technique withmore » multiple pump beam radii.« less

A Waved Journal Bearing Concept-Evaluating Steady-State and Dynamic Performance with a Potential Active Control Alternative

NASA Technical Reports Server (NTRS)

Dimofte, Florin

1993-01-01

Analysis of the waved journal bearing concept featuring a waved inner bearing diameter for use with a compressible lubricant (gas) is presented. The performance of generic waved bearings having either three or four waves is predicted for air lubricated bearings. Steady-state performance is discussed in terms of bearing load capacity, while the dynamic performance is discussed in terms of fluid film stability and dynamic coefficients. It was found that the bearing wave amplitude has an important influence on both the steady-state and the dynamic performance of the waved journal bearing. For a fixed eccentricity ratio, the bearing steady-state load capacity and direct dynamic stiffness coefficient increase as the wave amplitude increases.

[Specific features in realization of the principle of minimum energy dissipation during individual development].

PubMed

Zotin, A A

2012-01-01

Realization of the principle of minimum energy dissipation (Prigogine's theorem) during individual development has been analyzed. This analysis has suggested the following reformulation of this principle for living objects: when environmental conditions are constant, the living system evolves to a current steady state in such a way that the difference between entropy production and entropy flow (psi(u) function) is positive and constantly decreases near the steady state, approaching zero. In turn, the current steady state tends to a final steady state in such a way that the difference between the specific entropy productions in an organism and its environment tends to be minimal. In general, individual development completely agrees with the law of entropy increase (second law of thermodynamics).

Fabrication and Characterization of Ultrathin-ring Electrodes for Pseudo-steady-state Amperometric Detection.

PubMed

Kitazumi, Yuki; Hamamoto, Katsumi; Noda, Tatsuo; Shirai, Osamu; Kano, Kenji

2015-01-01

The fabrication of ultrathin-ring electrodes with a diameter of 2 mm and a thickness of 100 nm is established. The ultrathin-ring electrodes provide a large density of pseudo-steady-state currents, and realize pseudo-steady-state amperometry under quiescent conditions without a Faraday cage. Under the limiting current conditions, the current response at the ultrathin-ring electrode can be well explained by the theory of the microband electrode response. Cyclic voltammograms at the ultrathin-ring electrode show sigmoidal characteristics with some hysteresis. Numerical simulation reveals that the hysteresis can be ascribed to the time-dependence of pseudo-steady-state current. The performance of amperometry with the ultrathin-ring electrode has been verified in its application to redox enzyme kinetic measurements.

Dissipative production of a maximally entangled steady state of two quantum bits.

PubMed

Lin, Y; Gaebler, J P; Reiter, F; Tan, T R; Bowler, R; Sørensen, A S; Leibfried, D; Wineland, D J

2013-12-19

Entangled states are a key resource in fundamental quantum physics, quantum cryptography and quantum computation. Introduction of controlled unitary processes--quantum gates--to a quantum system has so far been the most widely used method to create entanglement deterministically. These processes require high-fidelity state preparation and minimization of the decoherence that inevitably arises from coupling between the system and the environment, and imperfect control of the system parameters. Here we combine unitary processes with engineered dissipation to deterministically produce and stabilize an approximate Bell state of two trapped-ion quantum bits (qubits), independent of their initial states. Compared with previous studies that involved dissipative entanglement of atomic ensembles or the application of sequences of multiple time-dependent gates to trapped ions, we implement our combined process using trapped-ion qubits in a continuous time-independent fashion (analogous to optical pumping of atomic states). By continuously driving the system towards the steady state, entanglement is stabilized even in the presence of experimental noise and decoherence. Our demonstration of an entangled steady state of two qubits represents a step towards dissipative state engineering, dissipative quantum computation and dissipative phase transitions. Following this approach, engineered coupling to the environment may be applied to a broad range of experimental systems to achieve desired quantum dynamics or steady states. Indeed, concurrently with this work, an entangled steady state of two superconducting qubits was demonstrated using dissipation.

Poiseuille flow of soft glasses in narrow channels: from quiescence to steady state.

PubMed

Chaudhuri, Pinaki; Horbach, Jürgen

2014-10-01

Using numerical simulations, the onset of Poiseuille flow in a confined soft glass is investigated. Starting from the quiescent state, steady flow sets in at a time scale which increases with a decrease in applied forcing. At this onset time scale, a rapid transition occurs via the simultaneous fluidization of regions having different local stresses. In the absence of steady flow at long times, creep is observed even in regions where the local stress is larger than the bulk yielding threshold. Finally, we show that the time scale to attain steady flow depends strongly on the history of the initial state.

Bipolar pulse field for magnetic refrigeration

DOEpatents

Lubell, M.S.

1994-10-25

A magnetic refrigeration apparatus includes first and second steady state magnets, each having a field of substantially equal strength and opposite polarity, first and second bodies made of magnetocaloric material disposed respectively in the influence of the fields of the first and second steady state magnets, and a pulsed magnet, concentric with the first and second steady state magnets, and having a field which cycles between the fields of the first and second steady state magnets, thereby cyclically magnetizing and demagnetizing and thus heating and cooling the first and second bodies. Heat exchange apparatus of suitable design can be used to expose a working fluid to the first and second bodies of magnetocaloric material. A controller is provided to synchronize the flow of working fluid with the changing states of magnetization of the first and second bodies. 2 figs.

Steady-state kinetic modeling constrains cellular resting states and dynamic behavior.

PubMed

Purvis, Jeremy E; Radhakrishnan, Ravi; Diamond, Scott L

2009-03-01

A defining characteristic of living cells is the ability to respond dynamically to external stimuli while maintaining homeostasis under resting conditions. Capturing both of these features in a single kinetic model is difficult because the model must be able to reproduce both behaviors using the same set of molecular components. Here, we show how combining small, well-defined steady-state networks provides an efficient means of constructing large-scale kinetic models that exhibit realistic resting and dynamic behaviors. By requiring each kinetic module to be homeostatic (at steady state under resting conditions), the method proceeds by (i) computing steady-state solutions to a system of ordinary differential equations for each module, (ii) applying principal component analysis to each set of solutions to capture the steady-state solution space of each module network, and (iii) combining optimal search directions from all modules to form a global steady-state space that is searched for accurate simulation of the time-dependent behavior of the whole system upon perturbation. Importantly, this stepwise approach retains the nonlinear rate expressions that govern each reaction in the system and enforces constraints on the range of allowable concentration states for the full-scale model. These constraints not only reduce the computational cost of fitting experimental time-series data but can also provide insight into limitations on system concentrations and architecture. To demonstrate application of the method, we show how small kinetic perturbations in a modular model of platelet P2Y(1) signaling can cause widespread compensatory effects on cellular resting states.

A descriptive model of resting-state networks using Markov chains.

PubMed

Xie, H; Pal, R; Mitra, S

2016-08-01

Resting-state functional connectivity (RSFC) studies considering pairwise linear correlations have attracted great interests while the underlying functional network structure still remains poorly understood. To further our understanding of RSFC, this paper presents an analysis of the resting-state networks (RSNs) based on the steady-state distributions and provides a novel angle to investigate the RSFC of multiple functional nodes. This paper evaluates the consistency of two networks based on the Hellinger distance between the steady-state distributions of the inferred Markov chain models. The results show that generated steady-state distributions of default mode network have higher consistency across subjects than random nodes from various RSNs.

Testing genuine tripartite quantum nonlocality with three two-level atoms in a driven cavity

NASA Astrophysics Data System (ADS)

Yuan, H.; Wei, L. F.

2013-10-01

It is known that the violation of Svetlichny's inequality (SI), rather than the usual Mermin's inequality (MI), is a robust criterion to confirm the existence of genuine multipartite quantum nonlocality. In this paper, we propose a feasible approach to test SI with three two-level atoms (TLAs) dispersively coupled to a driven cavity. The proposal is based on the joint measurements of the states of three TLAs by probing the steady-state transmission spectra of the driven cavity: each peak marks one of the computational basis states and its relative height corresponds to the probability superposed in the detected three-TLA state. With these kinds of joint measurements, the correlation functions in SI can be directly calculated, and thus the SI can be efficiently tested for typical tripartite entanglement, i.e., genuine tripartite entanglement [e.g., Greenberger-Horne-Zeilinger (GHZ) and W states] and biseparable three-qubit entangled states (e.g., |χ>12|ξ>3). Our numerical experiments show that the SI is violated only by three-qubit GHZ and W states, not by biseparable three-qubit entangled state |χ>12|ξ>3, while the MI can still be violated by biseparable three-qubit entangled states. Thus the violation of SI can be regarded as a robust criterion for the existence of genuine tripartite entanglement.

Results of the ETV-1 breadboard tests under steady-state and transient conditions. [conducted in the NASA-LeRC Road Load Simulator

NASA Technical Reports Server (NTRS)

Sargent, N. B.; Dustin, M. O.

1981-01-01

Steady state tests were run to characterize the system and component efficiencies over the complete speed-torque capabilities of the propulsion system in both motoring and regenerative modes of operation. The steady state data were obtained using a battery simulator to separate the effects on efficiency caused by changing battery state-of-charge and component temperature. Transient tests were performed to determine the energy profiles of the propulsion system operating over the SAE J227a driving schedules.

Experimental investigation of cryogenic oscillating heat pipes.

PubMed

Jiao, A J; Ma, H B; Critser, J K

2009-07-01

A novel cryogenic heat pipe, oscillating heat pipe (OHP), which consists of an 4 × 18.5 cm evaporator, a 6 × 18.5 cm condenser, and 10 cm length of adiabatic section, has been developed and experimental characterization conducted. Experimental results show that the maximum heat transport capability of the OHP reached 380W with average temperature difference of 49 °C between the evaporator and condenser when the cryogenic OHP was charged with liquid nitrogen at 48% (v/v) and operated in a horizontal direction. The thermal resistance decreased from 0.256 to 0.112 while the heat load increased from 22.5 to 321.8 W. When the OHP was operated at a steady state and an incremental heat load was added to it, the OHP operation changed from a steady state to an unsteady state until a new steady state was reached. This process can be divided into three regions: (I) unsteady state; (II) transient state; and (III) new steady state. In the steady state, the amplitude of temperature change in the evaporator is smaller than that of the condenser while the temperature response keeps the same frequency both in the evaporator and the condenser. The experimental results also showed that the amplitude of temperature difference between the evaporator and the condenser decreased when the heat load increased.

Experimental investigation of cryogenic oscillating heat pipes

PubMed Central

Jiao, A.J.; Ma, H.B.; Critser, J.K.

2010-01-01

A novel cryogenic heat pipe, oscillating heat pipe (OHP), which consists of an 4 × 18.5 cm evaporator, a 6 × 18.5 cm condenser, and 10 cm length of adiabatic section, has been developed and experimental characterization conducted. Experimental results show that the maximum heat transport capability of the OHP reached 380W with average temperature difference of 49 °C between the evaporator and condenser when the cryogenic OHP was charged with liquid nitrogen at 48% (v/v) and operated in a horizontal direction. The thermal resistance decreased from 0.256 to 0.112 while the heat load increased from 22.5 to 321.8 W. When the OHP was operated at a steady state and an incremental heat load was added to it, the OHP operation changed from a steady state to an unsteady state until a new steady state was reached. This process can be divided into three regions: (I) unsteady state; (II) transient state; and (III) new steady state. In the steady state, the amplitude of temperature change in the evaporator is smaller than that of the condenser while the temperature response keeps the same frequency both in the evaporator and the condenser. The experimental results also showed that the amplitude of temperature difference between the evaporator and the condenser decreased when the heat load increased. PMID:20585410

Slow and deep respiration suppresses steady-state sympathetic nerve activity in patients with chronic heart failure: from modeling to clinical application.

PubMed

Harada, Daisuke; Asanoi, Hidetsugu; Takagawa, Junya; Ishise, Hisanari; Ueno, Hiroshi; Oda, Yoshitaka; Goso, Yukiko; Joho, Shuji; Inoue, Hiroshi

2014-10-15

Influences of slow and deep respiration on steady-state sympathetic nerve activity remain controversial in humans and could vary depending on disease conditions and basal sympathetic nerve activity. To elucidate the respiratory modulation of steady-state sympathetic nerve activity, we modeled the dynamic nature of the relationship between lung inflation and muscle sympathetic nerve activity (MSNA) in 11 heart failure patients with exaggerated sympathetic outflow at rest. An autoregressive exogenous input model was utilized to simulate entire responses of MSNA to variable respiratory patterns. In another 18 patients, we determined the influence of increasing tidal volume and slowing respiratory frequency on MSNA; 10 patients underwent a 15-min device-guided slow respiration and the remaining 8 had no respiratory modification. The model predicted that a 1-liter, step increase of lung volume decreased MSNA dynamically; its nadir (-33 ± 22%) occurred at 2.4 s; and steady-state decrease (-15 ± 5%), at 6 s. Actually, in patients with the device-guided slow and deep respiration, respiratory frequency effectively fell from 16.4 ± 3.9 to 6.7 ± 2.8/min (P < 0.0001) with a concomitant increase in tidal volume from 499 ± 206 to 1,177 ± 497 ml (P < 0.001). Consequently, steady-state MSNA was decreased by 31% (P < 0.005). In patients without respiratory modulation, there were no significant changes in respiratory frequency, tidal volume, and steady-state MSNA. Thus slow and deep respiration suppresses steady-state sympathetic nerve activity in patients with high levels of resting sympathetic tone as in heart failure. Copyright © 2014 the American Physiological Society.

Spatial variability of steady-state infiltration into a two-layer soil system on burned hillslopes

USGS Publications Warehouse

Kinner, D.A.; Moody, J.A.

2010-01-01

Rainfall-runoff simulations were conducted to estimate the characteristics of the steady-state infiltration rate into 1-m2 north- and south-facing hillslope plots burned by a wildfire in October 2003. Soil profiles in the plots consisted of a two-layer system composed of an ash on top of sandy mineral soil. Multiple rainfall rates (18.4-51.2 mm h-1) were used during 14 short-duration (30 min) and 2 long-duration simulations (2-4 h). Steady state was reached in 7-26 min. Observed spatially-averaged steady-state infiltration rates ranged from 18.2 to 23.8 mm h-1 for north-facing and from 17.9 to 36.0 mm h-1 for south-facing plots. Three different theoretical spatial distribution models of steady-state infiltration rate were fit to the measurements of rainfall rate and steady-state discharge to provided estimates of the spatial average (19.2-22.2 mm h-1) and the coefficient of variation (0.11-0.40) of infiltration rates, overland flow contributing area (74-90% of the plot area), and infiltration threshold (19.0-26 mm h-1). Tensiometer measurements indicated a downward moving pressure wave and suggest that infiltration-excess overland flow is the runoff process on these burned hillslope with a two-layer system. Moreover, the results indicate that the ash layer is wettable, may restrict water flow into the underlying layer, and increase the infiltration threshold; whereas, the underlying mineral soil, though coarser, limits the infiltration rate. These results of the spatial variability of steady-state infiltration can be used to develop physically-based rainfall-runoff models for burned areas with a two-layer soil system. ?? 2010 Elsevier B.V.

Steady states of a diode with counterstreaming electron and positron beams

DOE Office of Scientific and Technical Information (OSTI.GOV)

Ender, A. Ya.; Kuznetsov, V. I., E-mail: victor.kuznetsov@mail.ioffe.ru; Gruzdev, A. A.

2016-10-15

Steady states of a plasma layer with counterstreaming beams of oppositely charged particles moving without collisions in a self-consistent electric field are analyzed. The study is aimed at clarifying the mechanism of generation and reconstruction of pulsar radiation. Such a layer also models the processes occurring in Knudsen plasma diodes with counterstreaming electron and ion beams. The steady-state solutions are exhaustively classified. The existence of several solutions at the same external parameters is established.

Steady states of a diode with counterstreaming electron and positron beams

NASA Astrophysics Data System (ADS)

Ender, A. Ya.; Kuznetsov, V. I.; Gruzdev, A. A.

2016-10-01

Steady states of a plasma layer with counterstreaming beams of oppositely charged particles moving without collisions in a self-consistent electric field are analyzed. The study is aimed at clarifying the mechanism of generation and reconstruction of pulsar radiation. Such a layer also models the processes occurring in Knudsen plasma diodes with counterstreaming electron and ion beams. The steady-state solutions are exhaustively classified. The existence of several solutions at the same external parameters is established.

Transient and steady-state performance of a single turbojet combustor with four different fuel nozzles

NASA Technical Reports Server (NTRS)

Mccafferty, Richard J; Donlon, Richard H

1955-01-01

Acceleration and steady-state performance of a tubular combustor was evaluated at two simulated altitudes with four different fuel nozzles. Temperature response lag was observed with all the nozzles. Except for rich-limit blowout, the only combustion failures observed during acceleration were with a fuel nozzle that gave an interrupted flow delivery during the acceleration. This same nozzle, because of superior fuel atomization, gave the highest steady-state combustion efficiencies.

Lactate and Acrylate Metabolism by Megasphaera elsdenii under Batch and Steady-State Conditions

PubMed Central

Prabhu, Rupal; Altman, Elliot

2012-01-01

The growth of Megasphaera elsdenii on lactate with acrylate and acrylate analogues was studied under batch and steady-state conditions. Under batch conditions, lactate was converted to acetate and propionate, and acrylate was converted into propionate. Acrylate analogues 2-methyl propenoate and 3-butenoate containing a terminal double bond were similarly converted into their respective saturated acids (isobutyrate and butyrate), while crotonate and lactate analogues 3-hydroxybutyrate and (R)-2-hydroxybutyrate were not metabolized. Under carbon-limited steady-state conditions, lactate was converted to acetate and butyrate with no propionate formed. As the acrylate concentration in the feed was increased, butyrate and hydrogen formation decreased and propionate was increasingly generated, while the calculated ATP yield was unchanged. M. elsdenii metabolism differs substantially under batch and steady-state conditions. The results support the conclusion that propionate is not formed during lactate-limited steady-state growth because of the absence of this substrate to drive the formation of lactyl coenzyme A (CoA) via propionyl-CoA transferase. Acrylate and acrylate analogues are reduced under both batch and steady-state growth conditions after first being converted to thioesters via propionyl-CoA transferase. Our findings demonstrate the central role that CoA transferase activity plays in the utilization of acids by M. elsdenii and allows us to propose a modified acrylate pathway for M. elsdenii. PMID:23023753

A critical investigation of post-liquefaction strength and steady-state flow behavior of saturated soils

DOE Office of Scientific and Technical Information (OSTI.GOV)

Jong, H.L.

1988-01-01

The first objective was to perform a critical evaluation of the recently proposed steady-state analysis methodology for evaluation of post-liquefaction stability of potentially liquefiable soils. This analysis procedure is based on direct comparison between the in-situ undrained residual (steady state) strength of soils in an embankment or foundation, and the driving shear stresses in these soils. A laboratory investigation was performed to investigate factors affecting steady-state strengths, and also to evaluate the validity of assumptions involved in correcting the results of laboratory steady-state strength tests on undisturbed samples for effects of sampling disturbance in order to estimate in-situ strengths. Next,more » a field case study was performed using the steady-state analysis and testing methodologies to analyze Lower San Fernando Dam, which suffered a liquefaction-induced slope failure as a results of a 1971 earthquake. This leads to the second objective which was to extend the Lower San Fernando Dam case study to consideration of analysis methods used to evaluate the likelihood of triggering liquefaction during an earthquake. Finally, a number of the high quality undisturbed samples were subjected to undrained cyclic testing in order to repeat an earlier (1973) study of the use of cyclic tests data to predict liquefaction behavior at Lower San Fernando Dam.« less

Prospective evaluation of haemoglobin oxygen saturation at rest and after exercise in paediatric sickle cell disease patients

PubMed Central

Campbell, Andrew; Minniti, Caterina P.; Nouraie, Mehdi; Arteta, Manuel; Rana, Sohail; Onyekwere, Onyinye; Sable, Craig; Ensing, Gregory; Dham, Niti; Luchtman-Jones, Lori; Kato, Gregory J.; Gladwin, Mark T.; Castro, Oswaldo L.; Gordeuk, Victor R.

2009-01-01

Summary Low steady state haemoglobin oxygen saturation in patients with sickle cell anaemia has been associated with the degree of anaemia and haemolysis. How much pulmonary dysfunction contributes to low saturation is not clear. In a prospective study of children and adolescents with sickle cell disease aged 3–20 years at steady state and matched controls, 52% of 391 patients versus 24% of 63 controls had steady state oxygen saturation <99% (P < 0·0001), 9% of patients versus no controls had saturation <95% (P = 0·008) and 8% of patients versus no controls had exercise-induced reduction in saturation ≥3%. Decreasing haemoglobin concentration (P ≤ 0·001) and increasing haemolysis (P ≤ 0·003) but not pulmonary function tests were independent predictors of both lower steady-state saturation and exercise-induced reduction in saturation. Neither history of stroke nor history of acute chest syndrome was significantly associated with lower steady-state oxygen saturation or exercise-induced reduction in saturation. Tricuspid regurgitation velocity was higher in patients with lower steady state haemoglobin oxygen saturation (P = 0·003) and with greater decline in oxygen saturation during the six-minute walk (P = 0·022). In conclusion, lower haemoglobin oxygen saturation is independently associated with increasing degrees of anaemia and haemolysis but not pulmonary function abnormalities among children and adolescents with sickle cell disease. PMID:19694721

Nitrogen Can Alleviate the Inhibition of Photosynthesis Caused by High Temperature Stress under Both Steady-State and Flecked Irradiance.

PubMed

Huang, Guanjun; Zhang, Qiangqiang; Wei, Xinghai; Peng, Shaobing; Li, Yong

2017-01-01

Nitrogen is one of the most important elements for plants and is closely related to photosynthesis. High temperature stress significantly inhibits photosynthesis under both steady-state and flecked irradiance. However, it is not known whether nitrogen can affect the decrease in photosynthesis caused by high temperature, especially under flecked irradiance. In the present study, a pot experiment was conducted under two nitrogen (N) supplies with rice plants, and the steady-state and dynamic photosynthesis rates were measured under 28 and 40°C. High temperature significantly increased leaf hydraulic conductance ( K leaf ) under high N supply (HN) but not under low N supply (LN). The increased K leaf maintained a constant leaf water potential (Ψ leaf ) and steady-state stomatal conductance ( g s,sat ) under HN, while the Ψ leaf and g s,sat significantly decreased under high temperature in LN conditions. This resulted in a more severe decrease in steady-state photosynthesis ( A sat ) under high temperature in the LN conditions. After shifting from low to high light, high temperature significantly delayed the recovery of photosynthesis, which resulted in more carbon loss under flecked irradiance. These effects were obtained under HN to a lesser extent than under LN supply. Therefore, it is concluded that nitrogen can alleviate the inhibition of photosynthesis caused by high temperature stress under both steady-state and flecked irradiance.

Quasi-steady-state voltammetry of rapid electron transfer reactions at the macroscopic substrate of the scanning electrochemical microscope.

PubMed

Nioradze, Nikoloz; Kim, Jiyeon; Amemiya, Shigeru

2011-02-01

We report on a novel theory and experiment for scanning electrochemical microscopy (SECM) to enable quasi-steady-state voltammetry of rapid electron transfer (ET) reactions at macroscopic substrates. With this powerful approach, the substrate potential is cycled widely across the formal potential of a redox couple while the reactant or product of a substrate reaction is amperometrically detected at the tip in the feedback or substrate generation/tip collection mode, respectively. The plot of tip current versus substrate potential features the retraceable sigmoidal shape of a quasi-steady-state voltammogram although a transient voltammogram is obtained at the macroscopic substrate. Finite element simulations reveal that a short tip-substrate distance and a reversible substrate reaction (except under the tip) are required for quasi-steady-state voltammetry. Advantageously, a pair of quasi-steady-state voltammograms is obtained by employing both operation modes to reliably determine all transport, thermodynamic, and kinetic parameters as confirmed experimentally for rapid ET reactions of ferrocenemethanol and 7,7,8,8-tetracyanoquinodimethane at a Pt substrate with ∼0.5 μm-radius Pt tips positioned at 90 nm-1 μm distances. Standard ET rate constants of ∼7 cm/s were obtained for the latter mediator as the largest determined for a substrate reaction by SECM. Various potential applications of quasi-steady-state voltammetry are also proposed.

Role of irregular otolith afferents in the steady-state nystagmus during off-vertical axis rotation

NASA Technical Reports Server (NTRS)

Angelaki, D. E.; Perachio, A. A.; Mustari, M. J.; Strunk, C. L.

1992-01-01

1. During constant velocity off-vertical axis rotations (OVAR) in the dark a compensatory ocular nystagmus is present throughout rotation despite the lack of a maintained signal from the semicircular canals. Lesion experiments and canal plugging have attributed the steady-state ocular nystagmus during OVAR to inputs from the otolith organs and have demonstrated that it depends on an intact velocity storage mechanism. 2. To test whether irregularly discharging otolith afferents play a crucial role in the generation of the steady-state eye nystagmus during OVAR, we have used anodal (inhibitory) currents bilaterally to selectively and reversibly block irregular vestibular afferent discharge. During delivery of DC anodal currents (100 microA) bilaterally to both ears, the slow phase eye velocity of the steady-state nystagmus during OVAR was reduced or completely abolished. The disruption of the steady-state nystagmus was transient and lasted only during the period of galvanic stimulation. 3. To distinguish a possible effect of ablation of the background discharge rates of irregular vestibular afferents on the velocity storage mechanism from specific contributions of the dynamic responses from irregular otolith afferents to the circuit responsible for the generation of the steady-state nystagmus, bilateral DC anodal galvanic stimulation was applied during optokinetic nystagmus (OKN) and optokinetic afternystagmus (OKAN). No change in OKN and OKAN was observed.(ABSTRACT TRUNCATED AT 250 WORDS).

Smooth Approximation l 0-Norm Constrained Affine Projection Algorithm and Its Applications in Sparse Channel Estimation

PubMed Central

2014-01-01

We propose a smooth approximation l 0-norm constrained affine projection algorithm (SL0-APA) to improve the convergence speed and the steady-state error of affine projection algorithm (APA) for sparse channel estimation. The proposed algorithm ensures improved performance in terms of the convergence speed and the steady-state error via the combination of a smooth approximation l 0-norm (SL0) penalty on the coefficients into the standard APA cost function, which gives rise to a zero attractor that promotes the sparsity of the channel taps in the channel estimation and hence accelerates the convergence speed and reduces the steady-state error when the channel is sparse. The simulation results demonstrate that our proposed SL0-APA is superior to the standard APA and its sparsity-aware algorithms in terms of both the convergence speed and the steady-state behavior in a designated sparse channel. Furthermore, SL0-APA is shown to have smaller steady-state error than the previously proposed sparsity-aware algorithms when the number of nonzero taps in the sparse channel increases. PMID:24790588

[Study on balance group in steady-state extraction process of Chinese medicine and experimental verification to Houttuynia cordata].

PubMed

Liu, Wenlong; Zhang, Xili; He, Fuyuan; Zhang, Ping; Wang, Haiqin; Wu, Dezhi; Chen, Zuohong

2011-11-01

To establish and experimental verification the mathematical model of the balance groups that is the steady-state of traditional Chinese medicine in extraction. Using the entropy and genetic principles of statistics, and taking the coefficient of variation of GC fingerprint which is the naphtha of the Houttuynia cordata between strains in the same GAP place as a pivot to establish and verify the mathematical model was established of the balance groups that is the steady-state of traditional Chinese medicine in extraction. A mathematical model that is suitable for the balance groups of the steady-state of traditional Chinese medicine and preparation in extraction, and the balance groups which is 29 683 strains (approximately 118.7 kg) were gained with the same origin of H. cordata as the model drug. Under the GAP of quality control model, controlling the stability of the quality through further using the Hardy-Weinberg balance groups of the H. cordata between strains, the new theory and experiment foundation is established for the steady-state of traditional Chinese medicine in extraction and quality control.

Advanced continuous cultivation methods for systems microbiology.

PubMed

Adamberg, Kaarel; Valgepea, Kaspar; Vilu, Raivo

2015-09-01

Increasing the throughput of systems biology-based experimental characterization of in silico-designed strains has great potential for accelerating the development of cell factories. For this, analysis of metabolism in the steady state is essential as only this enables the unequivocal definition of the physiological state of cells, which is needed for the complete description and in silico reconstruction of their phenotypes. In this review, we show that for a systems microbiology approach, high-resolution characterization of metabolism in the steady state--growth space analysis (GSA)--can be achieved by using advanced continuous cultivation methods termed changestats. In changestats, an environmental parameter is continuously changed at a constant rate within one experiment whilst maintaining cells in the physiological steady state similar to chemostats. This increases the resolution and throughput of GSA compared with chemostats, and, moreover, enables following of the dynamics of metabolism and detection of metabolic switch-points and optimal growth conditions. We also describe the concept, challenge and necessary criteria of the systematic analysis of steady-state metabolism. Finally, we propose that such systematic characterization of the steady-state growth space of cells using changestats has value not only for fundamental studies of metabolism, but also for systems biology-based metabolic engineering of cell factories.

Effect of antacids on predicted steady-state cimetidine concentrations.

PubMed

Russell, W L; Lopez, L M; Normann, S A; Doering, P L; Guild, R T

1984-05-01

The purpose of this study was to evaluate effects of antacids on predicted steady-state concentrations of cimetidine. Ten healthy volunteers received in random order one week apart, cimetidine and cimetidine and antacid suspension. Blood was obtained at specified times and analyzed for cimetidine. Bioavailability was assessed by comparison of peak concentration, time to peak concentration, area under the curve, and time spent over 0.5 micrograms/ml. Single-dose data were extrapolated to steady-state using computer simulation. Concurrent administration of antacid suspension reduced parameters of bioavailability approximately 30%. When steady-state conditions were simulated, concentrations of cimetidine greater than or equal to 0.5 micrograms/ml were maintained for the entire dosing interval in seven of 10 subjects. These data suggest that temporal separation of cimetidine and antacid suspension may be unnecessary.

Interplay of interaction and disorder in the steady state of an open quantum system

NASA Astrophysics Data System (ADS)

Xu, Xiansong; Guo, Chu; Poletti, Dario

2018-04-01

Many types of dissipative processes can be found in nature or be engineered, and their interplay with a system can give rise to interesting phases of matter. Here we study the interplay among interaction, tunneling, and disorder in the steady state of a spin chain coupled to a tailored bath. We consider a dissipation which, in contrast to disorder, tends to generate a homogeneously polarized steady state. We find that the steady state can be highly sensitive even to weak disorder. We also establish that, in the presence of such dissipation, even in the absence of interaction, a finite amount of disorder is needed for localization. Last, we show that for strong disorder the system reveals signatures of localization both in the weakly and strong interacting regimes.

Exact results for Schrödinger cats in driven-dissipative systems and their feedback control

NASA Astrophysics Data System (ADS)

Minganti, Fabrizio; Bartolo, Nicola; Lolli, Jared; Casteels, Wim; Ciuti, Cristiano

2016-05-01

In quantum optics, photonic Schrödinger cats are superpositions of two coherent states with opposite phases and with a significant number of photons. Recently, these states have been observed in the transient dynamics of driven-dissipative resonators subject to engineered two-photon processes. Here we present an exact analytical solution of the steady-state density matrix for this class of systems, including one-photon losses, which are considered detrimental for the achievement of cat states. We demonstrate that the unique steady state is a statistical mixture of two cat-like states with opposite parity, in spite of significant one-photon losses. The transient dynamics to the steady state depends dramatically on the initial state and can pass through a metastable regime lasting orders of magnitudes longer than the photon lifetime. By considering individual quantum trajectories in photon-counting configuration, we find that the system intermittently jumps between two cats. Finally, we propose and study a feedback protocol based on this behaviour to generate a pure cat-like steady state.

Mathematical Analysis of Vehicle Delivery Scale of Bike-Sharing Rental Nodes

NASA Astrophysics Data System (ADS)

Zhai, Y.; Liu, J.; Liu, L.

2018-04-01

Aiming at the lack of scientific and reasonable judgment of vehicles delivery scale and insufficient optimization of scheduling decision, based on features of the bike-sharing usage, this paper analyses the applicability of the discrete time and state of the Markov chain, and proves its properties to be irreducible, aperiodic and positive recurrent. Based on above analysis, the paper has reached to the conclusion that limit state (steady state) probability of the bike-sharing Markov chain only exists and is independent of the initial probability distribution. Then this paper analyses the difficulty of the transition probability matrix parameter statistics and the linear equations group solution in the traditional solving algorithm of the bike-sharing Markov chain. In order to improve the feasibility, this paper proposes a "virtual two-node vehicle scale solution" algorithm which considered the all the nodes beside the node to be solved as a virtual node, offered the transition probability matrix, steady state linear equations group and the computational methods related to the steady state scale, steady state arrival time and scheduling decision of the node to be solved. Finally, the paper evaluates the rationality and accuracy of the steady state probability of the proposed algorithm by comparing with the traditional algorithm. By solving the steady state scale of the nodes one by one, the proposed algorithm is proved to have strong feasibility because it lowers the level of computational difficulty and reduces the number of statistic, which will help the bike-sharing companies to optimize the scale and scheduling of nodes.

Current Pressure Transducer Application of Model-based Prognostics Using Steady State Conditions

NASA Technical Reports Server (NTRS)

Teubert, Christopher; Daigle, Matthew J.

2014-01-01

Prognostics is the process of predicting a system's future states, health degradation/wear, and remaining useful life (RUL). This information plays an important role in preventing failure, reducing downtime, scheduling maintenance, and improving system utility. Prognostics relies heavily on wear estimation. In some components, the sensors used to estimate wear may not be fast enough to capture brief transient states that are indicative of wear. For this reason it is beneficial to be capable of detecting and estimating the extent of component wear using steady-state measurements. This paper details a method for estimating component wear using steady-state measurements, describes how this is used to predict future states, and presents a case study of a current/pressure (I/P) Transducer. I/P Transducer nominal and off-nominal behaviors are characterized using a physics-based model, and validated against expected and observed component behavior. This model is used to map observed steady-state responses to corresponding fault parameter values in the form of a lookup table. This method was chosen because of its fast, efficient nature, and its ability to be applied to both linear and non-linear systems. Using measurements of the steady state output, and the lookup table, wear is estimated. A regression is used to estimate the wear propagation parameter and characterize the damage progression function, which are used to predict future states and the remaining useful life of the system.

Experimental demonstration of revival of oscillations from death in coupled nonlinear oscillators.

PubMed

Senthilkumar, D V; Suresh, K; Chandrasekar, V K; Zou, Wei; Dana, Syamal K; Kathamuthu, Thamilmaran; Kurths, Jürgen

2016-04-01

We experimentally demonstrate that a processing delay, a finite response time, in the coupling can revoke the stability of the stable steady states, thereby facilitating the revival of oscillations in the same parameter space where the coupled oscillators suffered the quenching of oscillation. This phenomenon of reviving of oscillations is demonstrated using two different prototype electronic circuits. Further, the analytical critical curves corroborate that the spread of the parameter space with stable steady state is diminished continuously by increasing the processing delay. Finally, the death state is completely wiped off above a threshold value by switching the stability of the stable steady state to retrieve sustained oscillations in the same parameter space. The underlying dynamical mechanism responsible for the decrease in the spread of the stable steady states and the eventual reviving of oscillation as a function of the processing delay is explained using analytical results.

Pattern Formation in Keller-Segel Chemotaxis Models with Logistic Growth

NASA Astrophysics Data System (ADS)

Jin, Ling; Wang, Qi; Zhang, Zengyan

In this paper, we investigate pattern formation in Keller-Segel chemotaxis models over a multidimensional bounded domain subject to homogeneous Neumann boundary conditions. It is shown that the positive homogeneous steady state loses its stability as chemoattraction rate χ increases. Then using Crandall-Rabinowitz local theory with χ being the bifurcation parameter, we obtain the existence of nonhomogeneous steady states of the system which bifurcate from this homogeneous steady state. Stability of the bifurcating solutions is also established through rigorous and detailed calculations. Our results provide a selection mechanism of stable wavemode which states that the only stable bifurcation branch must have a wavemode number that minimizes the bifurcation value. Finally, we perform extensive numerical simulations on the formation of stable steady states with striking structures such as boundary spikes, interior spikes, stripes, etc. These nontrivial patterns can model cellular aggregation that develop through chemotactic movements in biological systems.

Experimental demonstration of revival of oscillations from death in coupled nonlinear oscillators

DOE Office of Scientific and Technical Information (OSTI.GOV)

Senthilkumar, D. V., E-mail: skumarusnld@gmail.com; Centre for Nonlinear Science and Engineering, School of Electrical and Electronics Engineering, SASTRA University, Thanjavur 613 401; Suresh, K.

We experimentally demonstrate that a processing delay, a finite response time, in the coupling can revoke the stability of the stable steady states, thereby facilitating the revival of oscillations in the same parameter space where the coupled oscillators suffered the quenching of oscillation. This phenomenon of reviving of oscillations is demonstrated using two different prototype electronic circuits. Further, the analytical critical curves corroborate that the spread of the parameter space with stable steady state is diminished continuously by increasing the processing delay. Finally, the death state is completely wiped off above a threshold value by switching the stability of themore » stable steady state to retrieve sustained oscillations in the same parameter space. The underlying dynamical mechanism responsible for the decrease in the spread of the stable steady states and the eventual reviving of oscillation as a function of the processing delay is explained using analytical results.« less

Determination of the Steady State Leakage Current in Structures with Ferroelectric Ceramic Films

NASA Astrophysics Data System (ADS)

Podgornyi, Yu. V.; Vorotilov, K. A.; Sigov, A. S.

2018-03-01

Steady state leakage currents have been investigated in capacitor structures with ferroelectric solgel films of lead zirconate titanate (PZT) formed on silicon substrates with a lower Pt electrode. It is established that Pt/PZT/Hg structures, regardless of the PZT film thickness, are characterized by the presence of a rectifying contact similar to p-n junction. The steady state leakage current in the forward direction increases with a decrease in the film thickness and is determined by the ferroelectric bulk conductivity.

Revelations of X-ray spectral analysis of the enigmatic black hole binary GRS 1915+105

NASA Astrophysics Data System (ADS)

Peris, Charith; Remillard, Ronald A.; Steiner, James; Vrtilek, Saeqa Dil; Varniere, Peggy; Rodriguez, Jerome; Pooley, Guy

2016-01-01

Of the black hole binaries discovered thus far, GRS 1915+105 stands out as an exceptional source primarily due to its wild X-ray variability, the diversity of which has not been replicated in any other stellar-mass black hole. Although extreme variability is commonplace in its light-curve, about half of the observations of GRS1915+105 show fairly steady X-ray intensity. We report on the X-ray spectral behavior within these steady observations. Our work is based on a vast RXTE/PCA data set obtained on GRS 1915+105 during the course of its entire mission and 10 years of radio data from the Ryle Telescope, which overlap the X-ray data. We find that the steady observations within the X-ray data set naturally separate into two regions in a color-color diagram, which we refer to as steady-soft and steady-hard. GRS 1915+105 displays significant curvature in the Comptonization component within the PCA band pass suggesting significantly heating from a hot disk present in all states. A new Comptonization model 'simplcut' was developed in order to model this curvature to best effect. A majority of the steady-soft observations display a roughly constant inner radius; remarkably reminiscent of canonical soft state black hole binaries. In contrast, the steady-hard observations display a growing disk truncation that is correlated to the mass accretion rate through the disk, which suggests a magnetically truncated disk. A comparison of X-ray model parameters to the canonical state definitions show that almost all steady-soft observations match the criteria of either thermal or steep power law state, while the thermal state observations dominate the constant radius branch. A large portion (80%) of the steady-hard observations matches the hard state criteria when the disk fraction constraint is neglected. These results suggest that within the complexity of this source is a simpler underlying basis of states, which map to those observed in canonical black hole binaries. When represented in a color-color diagram, state assignments appear to map to ``A, B and C'' (Belloni et al. 2000) regions that govern fast variability cycles in GRS 1915+105 demonstrating a compelling link between short and long time scales in its phenomenology.

ESTIMATING SYSTEMIC EXPOSURE TO ETHINYL ESTRADIOL FROM AN ORAL CONTRACEPTIVE

PubMed Central

WESTHOFF, Carolyn L.; PIKE, Malcolm C.; TANG, Rosalind; DINAPOLI, Marianne N.; SULL, Monica; CREMERS, Serge

2015-01-01

Objectives This study was conducted to compare single-dose pharmacokinetics of ethinyl estradiol in an oral contraceptive to steady-state values, and to assess whether any simpler measures could provide an adequate proxy of the ‘gold standard’ 24-hour steady-state area-under-the-curve. Identifying a simple, less expensive, measure of systemic ethinyl estradiol exposure would be useful for larger studies designed to assess the relationship between an individual’s ethinyl estradiol exposure and her side effects. Study Design We conducted a 13 samples over 24 hours pharmacokinetic analysis on day 1 and day 21 of the first cycle of a monophasic oral contraceptive containing 30 mcg ethinyl estradiol and 150 mcg levonorgestrel in 17 non-obese healthy white women. We also conducted an abbreviated single dose 9-sample pharmacokinetic analysis after a month washout. Ethinyl estradiol was measured by liquid chromatography-tandem mass spectrometry. We compared results of full 13-sample steady-state pharmacokinetic analysis with results calculated using fewer samples (9 or 5) and following the single doses. We calculated Pearson correlation coefficients to evaluate the relationships between these estimates of systemic ethinyl estradiol exposure. Results The area-under-the-curve, maximum (Cmax), and 24-hour (C24) values were similar following the two single oral contraceptive doses (area-under-the-curve, r = 0.92). The steady-state 13-sample 24-hour area-under-the-curve was highly correlated with the average 9-sample area-under-the-curve after the two single doses (r = 0.81, p = 0.0002). This correlation remained the same if the number of samples was reduced to 4, taken at time 1, 2.5, 4 and 24 hours. The C24 at steady-state was highly correlated with the 24-hour steady-state area-under-the-curve (r = 0.92, p < 0.0001). The average of the C24 values following the two single doses was also quite highly correlated with the steady-state area-under-the-curve (r = 0.72, p = 0.0026). Conclusions Limited blood sampling, including results from two single doses, gave highly correlated estimates of an oral contraceptive user’s steady-state ethinyl estradiol exposure. PMID:25511238

Estimating systemic exposure to ethinyl estradiol from an oral contraceptive.

PubMed

Westhoff, Carolyn L; Pike, Malcolm C; Tang, Rosalind; DiNapoli, Marianne N; Sull, Monica; Cremers, Serge

2015-05-01

This study was conducted to compare single-dose pharmacokinetics of ethinyl estradiol in an oral contraceptive with steady-state values and to assess whether any simpler measures could provide an adequate proxy of the "gold standard" 24-hour steady-state area under the curve (AUC) value. Identification of a simple, less expensive measure of systemic ethinyl estradiol exposure would be useful for larger studies that are designed to assess the relationship between an individual's ethinyl estradiol exposure and side-effects. We collected 13 samples over 24 hours for pharmacokinetic analysis on days 1 and 21 of the first cycle of a monophasic oral contraceptive that contained 30 μg ethinyl estradiol and 150 μg levonorgestrel in 17 nonobese healthy white women. We also conducted an abbreviated single-dose 9-sample pharmacokinetic analysis after a month washout. Ethinyl estradiol was measured by liquid chromatography-tandem mass spectrometry. We compared results of a full 13-sample steady-state pharmacokinetic analysis with results that had been calculated with the use of fewer samples (9 or 5) and after the single doses. We calculated Pearson correlation coefficients to evaluate the relationships between these estimates of systemic ethinyl estradiol exposure. The AUC, maximum, and 24-hour values were similar after the 2 single oral contraceptive doses (AUC; r=0.92). The steady-state 13-sample 24-hour AUC value was correlated highly with the average 9-sample AUC value after the 2 single doses (r=0.81; P=.0002). This correlation remained the same if the number of single-dose samples was reduced to 4, taken at time 1, 2.5, 4, and 24 hours. The 24-hour value at steady-state was correlated highly with the 24-hour steady-state AUC value (r=0.92; P<.0001). The average of the 24-hour values after the 2 single doses was also correlated quite highly with the steady-state AUC value (r=0.72; P=.0026). Limited blood sampling, including results from 2 single doses, gave highly correlated estimates of an oral contraceptive user's steady-state ethinyl estradiol exposure. Copyright © 2015 Elsevier Inc. All rights reserved.

Impact of material heterogeneity on solute transport behavior in the unsaturated zone of the Calcaire de Beauce aquifer (France)

NASA Astrophysics Data System (ADS)

Viel, Emelie; Coquet, Yves

2016-04-01

Since a few decades, the Calcaire de Beauce aquifer is contaminated with nitrate. The nitrate dynamics in the aquifer and in the surface soil are quite well understood, but its transport through the vadose zone remains largely unknown. When models fail to simulate nitrate concentrations in wells, preferential flow or physical non-equilibrium transport in soil and in the vadose zone is usually put forward to explain this failure. To study transport processes in the vadose zone of the Calcaire de Beauce aquifer, undisturbed cores (30 cm length and 20 cm diameter) have been taken below the deepest soil horizon. At the field scale, the vadose zone is composed of powdery limestone spatially very heterogeneous, and including a variable amount of coarse elements. Two columns were selected: column "6" is made of very fine homogeneous limestone whereas column "8" is very heterogeneous with a large proportion of coarse elements. Elution experiments have been performed on both columns. A tracer (Br- or DFBA) in a solution of 5 mM CaCl2 was spread as a pulse on the top of the column with a rainfall simulator. Input flow rate was kept constant for steady state cases, or suddenly closed for flux interruption cases. Outflow was collected as a function of time for tracer concentration measurement. The collected fractions were analyzed by HPLC (High-performance liquid chromatography) with a UV detector. Three types of experiments took place: • For steady state experiments, three rainfall rates, respectively 4, 8, and 16 mm/h, have been used to study the occurrence of immobile water in the columns. The tracer was injected during 120 min followed by CaCl2 tracer-free solution at same flow rate. • For flux-interruption experiments, only the 4 and 8 mm/h rainfall rates were used. The tracer was injected during 120 min, input and output fluxes were then stopped and restarted seven days later with the same flow rate. • For drainage experiments, only the 4 and 8 mm/h rainfall rates were used as well. The tracer was injected during 120 min, input flux was stopped while output flux continued to occur under the -25 cm matric head bottom boundary condition. Flux restarted seven days later with the same flow rate or another flow rate. STANMOD was used for each BTC to estimate transport parameters assuming steady state flux. The standard CDE was suitable for column 6 steady-state experiments, but the MIM had to be used to describe properly the BTCs of column 8. In this column, the immobile water fraction represented 38 %. Flux interruption experiments showed that the form of the BTC for Column 6 was not disturbed for the 4 and 8 mm/h input flux, whereas the form of BTC for Column 8 had significantly changed with a visible steeper increase after an interruption time compared to the corresponding steady state experiment. This difference of behavior could be related to the difference in limestone material. The immobile water fraction was found to be significant only for columns made of heterogeneous limestone.

A rapid method to extract Seebeck coefficient under a large temperature difference

NASA Astrophysics Data System (ADS)

Zhu, Qing; Kim, Hee Seok; Ren, Zhifeng

2017-09-01

The Seebeck coefficient is one of the three important properties in thermoelectric materials. Since thermoelectric materials usually work under large temperature difference in real applications, we propose a quasi-steady state method to accurately measure the Seebeck coefficient under large temperature gradient. Compared to other methods, this method is not only highly accurate but also less time consuming. It can measure the Seebeck coefficient in both the temperature heating up and cooling down processes. In this work, a Zintl material (Mg3.15Nb0.05Sb1.5Bi0.49Te0.01) was tested to extract the Seebeck coefficient from room temperature to 573 K. Compared with a commercialized Seebeck coefficient measurement device (ZEM-3), there is ±5% difference between those from ZEM-3 and this method.

An assessment of the adaptive unstructured tetrahedral grid, Euler Flow Solver Code FELISA

NASA Technical Reports Server (NTRS)

Djomehri, M. Jahed; Erickson, Larry L.

1994-01-01

A three-dimensional solution-adaptive Euler flow solver for unstructured tetrahedral meshes is assessed, and the accuracy and efficiency of the method for predicting sonic boom pressure signatures about simple generic models are demonstrated. Comparison of computational and wind tunnel data and enhancement of numerical solutions by means of grid adaptivity are discussed. The mesh generation is based on the advancing front technique. The FELISA code consists of two solvers, the Taylor-Galerkin and the Runge-Kutta-Galerkin schemes, both of which are spacially discretized by the usual Galerkin weighted residual finite-element methods but with different explicit time-marching schemes to steady state. The solution-adaptive grid procedure is based on either remeshing or mesh refinement techniques. An alternative geometry adaptive procedure is also incorporated.

Electrohydraulic Synchronizing Servo Control of a Robotic Arm

NASA Astrophysics Data System (ADS)

Li, S.; Ruan, J.; Pei, X.; Yu, Z. Q.; Zhu, F. M.

2006-10-01

The large robotic arm is usually driven by the electrodraulic synchronizing control system. The electrodraulic synchronizing system is designed with the digital valve to eliminate the effect of the nonlinearities, such as hysteresis, saturation, definite resolution. The working principle of the electrodraulic synchronizing control system is introduced and the mathematical model is established through construction of flow rate equation, continuity equation, force equilibrium equation, etc. To obtain the high accuracy, the PID control is introduced in the system. Simulation analysis shows that the dynamic performance of the synchronizing system is good, and its steady state error is very small. To validate the results, the experimental set-up of the synchronizing system is built. The experiment makes it clear that the control system has high accuracy. The synchronizing system can be applied widely in practice.

Non-consensus Opinion Models on Complex Networks

NASA Astrophysics Data System (ADS)

Li, Qian; Braunstein, Lidia A.; Wang, Huijuan; Shao, Jia; Stanley, H. Eugene; Havlin, Shlomo

2013-04-01

Social dynamic opinion models have been widely studied to understand how interactions among individuals cause opinions to evolve. Most opinion models that utilize spin interaction models usually produce a consensus steady state in which only one opinion exists. Because in reality different opinions usually coexist, we focus on non-consensus opinion models in which above a certain threshold two opinions coexist in a stable relationship. We revisit and extend the non-consensus opinion (NCO) model introduced by Shao et al. (Phys. Rev. Lett. 103:01870, 2009). The NCO model in random networks displays a second order phase transition that belongs to regular mean field percolation and is characterized by the appearance (above a certain threshold) of a large spanning cluster of the minority opinion. We generalize the NCO model by adding a weight factor W to each individual's original opinion when determining their future opinion (NCO W model). We find that as W increases the minority opinion holders tend to form stable clusters with a smaller initial minority fraction than in the NCO model. We also revisit another non-consensus opinion model based on the NCO model, the inflexible contrarian opinion (ICO) model (Li et al. in Phys. Rev. E 84:066101, 2011), which introduces inflexible contrarians to model the competition between two opinions in a steady state. Inflexible contrarians are individuals that never change their original opinion but may influence the opinions of others. To place the inflexible contrarians in the ICO model we use two different strategies, random placement and one in which high-degree nodes are targeted. The inflexible contrarians effectively decrease the size of the largest rival-opinion cluster in both strategies, but the effect is more pronounced under the targeted method. All of the above models have previously been explored in terms of a single network, but human communities are usually interconnected, not isolated. Because opinions propagate not only within single networks but also between networks, and because the rules of opinion formation within a network may differ from those between networks, we study here the opinion dynamics in coupled networks. Each network represents a social group or community and the interdependent links joining individuals from different networks may be social ties that are unusually strong, e.g., married couples. We apply the non-consensus opinion (NCO) rule on each individual network and the global majority rule on interdependent pairs such that two interdependent agents with different opinions will, due to the influence of mass media, follow the majority opinion of the entire population. The opinion interactions within each network and the interdependent links across networks interlace periodically until a steady state is reached. We find that the interdependent links effectively force the system from a second order phase transition, which is characteristic of the NCO model on a single network, to a hybrid phase transition, i.e., a mix of second-order and abrupt jump-like transitions that ultimately becomes, as we increase the percentage of interdependent agents, a pure abrupt transition. We conclude that for the NCO model on coupled networks, interactions through interdependent links could push the non-consensus opinion model to a consensus opinion model, which mimics the reality that increased mass communication causes people to hold opinions that are increasingly similar. We also find that the effect of interdependent links is more pronounced in interdependent scale free networks than in interdependent Erdős Rényi networks.

Compositional redistribution in alloy films under high-voltage electron microscope irradiation

NASA Astrophysics Data System (ADS)

Lam, Nghi Q.; Leaf, O. K.; Minkoff, M.

1983-10-01

The problem of nonequilibrium segregation in alloy films under high-voltage electron microscope (HVEM) irradiation at elevated temperatures is re-examined in the present work, taking into account the damage-rate gradients caused by radial variation in the electron flux. Axial and radial compositional redistributions in model solid solutions, representative of concentrated Ni-Cu, Ni-Al and Ni-Si alloys, were calculated as a function of time, temperature, and film thickness, using a kinetic theory of segregation in binary alloys. The numerical results were achieved by means of a new software package (DISPL2) for solving convection-diffusion-kinetics problems with general orthogonal geometries. It was found that HVEM irradiation-induced segregation in thin films consists of two stages. Initially, due to the proximity of the film surfaces as sinks for point defects, the usual axial segregation (to surfaces) occurs at relatively short irradiation times, and rapidly attains quasi-steady state. Then, radial segregation becomes more and more competitive, gradually affecting the kinetics of axial segregation. At a given temperature, the buildup time to steady state is much longer in the present situation than in the simple case of one-dimensional segregation with uniform defect production. Changes in the alloy composition occur in a much larger zone than the irradiated volume. As a result, the average alloy composition within the irradiated region can differ greatly from that of the unirradiated alloy. The present calculations may be useful in the interpretation of the kinetics of certain HVEM irradiation-induced processes in alloys.

Near-equilibrium desorption of helium films

NASA Astrophysics Data System (ADS)

Weimer, M.; Housley, R. M.; Goodstein, D. L.

1987-10-01

The thermal desorption of helium films in the presence of their equilibrium vapor is studied experimentally for small but rapid departures from ambient temperature. The results are analyzed within the framework of a quasithermodynamic phenomenological model based on detailed balance. Under the usual experimental conditions, isothermal desorption at the temperature of the substrate is a general prediction of the model which seems to be substantiated. For realistic adsorption isotherms the time evolution of the net desorption flux nevertheless appears to be governed by a highly nonlinear equation. In such circumstances, a number of characteristic relaxation times may be identified. These time scales are distinct from, and in general unrelated to, the coverage-dependent mean lifetime of an atom on the surface. To characterize the overall nonlinear evolution towards steady state, a global time scale, defined in terms of both initial- and steady-state properties, is introduced to summarize the experimental data. Internal evidence suggests a criterion for judging when collisions among desorbed atoms are unimportant. When this condition is satisfied, data for near-equilibrium desorption agree well with the predictions of the model. Combining our results with earlier data at higher substrate temperatures and different ambient conditions, the overall picture is consistent with scaling properties implied by the theory. We show that the values of the parameters deduced from a Frenkel-Arrhenius parametrization of the global relaxation times, as well as a variety of other aspects of desorption kinetics, are actually consequences of the shape of the equilibrium adsorption isotherm.

Propulsion System Simulation Using the Toolbox for the Modeling and Analysis of Thermodynamic System T-MATS

NASA Technical Reports Server (NTRS)

Chapman, Jeffryes W.; Lavelle, Thomas M.; May, Ryan D.; Litt, Jonathan S.; Guo, Ten-Huei

2014-01-01

A simulation toolbox has been developed for the creation of both steady-state and dynamic thermodynamic software models. This paper describes the Toolbox for the Modeling and Analysis of Thermodynamic Systems (T-MATS), which combines generic thermodynamic and controls modeling libraries with a numerical iterative solver to create a framework for the development of thermodynamic system simulations, such as gas turbine engines. The objective of this paper is to present an overview of T-MATS, the theory used in the creation of the module sets, and a possible propulsion simulation architecture. A model comparison was conducted by matching steady-state performance results from a T-MATS developed gas turbine simulation to a well-documented steady-state simulation. Transient modeling capabilities are then demonstrated when the steady-state T-MATS model is updated to run dynamically.

Propulsion System Simulation Using the Toolbox for the Modeling and Analysis of Thermodynamic Systems (T-MATS)

NASA Technical Reports Server (NTRS)

Chapman, Jeffryes W.; Lavelle, Thomas M.; May, Ryan D.; Litt, Jonathan S.; Guo, Ten-Huei

2014-01-01

A simulation toolbox has been developed for the creation of both steady-state and dynamic thermodynamic software models. This paper describes the Toolbox for the Modeling and Analysis of Thermodynamic Systems (T-MATS), which combines generic thermodynamic and controls modeling libraries with a numerical iterative solver to create a framework for the development of thermodynamic system simulations, such as gas turbine engines. The objective of this paper is to present an overview of T-MATS, the theory used in the creation of the module sets, and a possible propulsion simulation architecture. A model comparison was conducted by matching steady-state performance results from a T-MATS developed gas turbine simulation to a well-documented steady-state simulation. Transient modeling capabilities are then demonstrated when the steady-state T-MATS model is updated to run dynamically.

Coherent quantum dynamics in steady-state manifolds of strongly dissipative systems.

PubMed

Zanardi, Paolo; Campos Venuti, Lorenzo

2014-12-12

Recently, it has been realized that dissipative processes can be harnessed and exploited to the end of coherent quantum control and information processing. In this spirit, we consider strongly dissipative quantum systems admitting a nontrivial manifold of steady states. We show how one can enact adiabatic coherent unitary manipulations, e.g., quantum logical gates, inside this steady-state manifold by adding a weak, time-rescaled, Hamiltonian term into the system's Liouvillian. The effective long-time dynamics is governed by a projected Hamiltonian which results from the interplay between the weak unitary control and the fast relaxation process. The leakage outside the steady-state manifold entailed by the Hamiltonian term is suppressed by an environment-induced symmetrization of the dynamics. We present applications to quantum-computation in decoherence-free subspaces and noiseless subsystems and numerical analysis of nonadiabatic errors.

Fluctuations, Stratification and Stability in a Liquid Fluidized Bed at Low Reynolds Number

NASA Technical Reports Server (NTRS)

Segre, P. N.; McClymer, J. P.

2004-01-01

The sedimentation dynamics of extremely low polydispersity, non-colloidal, particles are studied in a liquid fluidized bed at low Reynolds number, Re much less than 1. When fluidized, the system reaches a steady state, defined where the local average volume fraction does not vary in time. In steady state, the velocity fluctuations and the particle concentrations are found to strongly depend on height. Using our results, we test a recently developed stability model for steady state sedimentation. The model describes the data well, and shows that in steady state there is a balancing of particle fluxes due to the fluctuations and the concentration gradient. Some results are also presented for the dependence of the concentration gradient in fluidized beds on particle size; the gradients become smaller as the particles become larger and fewer in number.

Acetylcholine-activated ionic currents in parasympathetic neurons of bullfrog heart.

PubMed

Tateishi, N; Kim, D K; Akaike, N

1990-05-01

1. The electrical and pharmacologic properties of acetylcholine (ACh)-induced current (IACh) were studied in the parasympathetic neurons isolated from bullfrog heart with the use of the concentration-clamp technique, which allows intracellular perfusion and rapid change of external solution within 2 ms under the single-electrode voltage-clamp condition. 2. The IACh consisted of an initial transient peak component and a successive steady-state plateau component. Both currents increased in a sigmoidal fashion with increasing ACh concentration. The dissociation constant (Kd value) and the Hill coefficient for each component were 2.2 X 10(-5) M and 1.6, respectively. 3. In the K(+)-free solution, the reversal potential (EACh) of IACh was close to the Na+ equilibrium potential (ENa). The current-voltage (I-V) relation showed inward rectification at positive potentials. 4. Nicotine mimicked only the peak component of IACh. However both peak and steady-state components were blocked nonselectively by the nicotinic blockers d-tubocurarine and hexamethonium. 5. Carbamylcholine (CCh) mimicked the steady-state component of IACh. The steady-state component was selectively inhibited by atropine at concentrations 1,000 times lower than that required for inhibition of the peak component. The steady state was blocked equally by either pirenzepine (M1 blocker) or AF-DX-116 (M2 blocker). 6. It was concluded that the IACh consisted of a peak component having double exponential activation and inactivation, mediated through the nicotinic actions, and a steady-state component having no inactivation, mediated through the muscarinic action.

Auditory steady-state response in cochlear implant patients.

PubMed

Torres-Fortuny, Alejandro; Arnaiz-Marquez, Isabel; Hernández-Pérez, Heivet; Eimil-Suárez, Eduardo

2018-03-19

Auditory steady state responses to continuous amplitude modulated tones at rates between 70 and 110Hz, have been proposed as a feasible alternative to objective frequency specific audiometry in cochlear implant subjects. The aim of the present study is to obtain physiological thresholds by means of auditory steady-state response in cochlear implant patients (Clarion HiRes 90K), with acoustic stimulation, on free field conditions and to verify its biological origin. 11 subjects comprised the sample. Four amplitude modulated tones of 500, 1000, 2000 and 4000Hz were used as stimuli, using the multiple frequency technique. The recording of auditory steady-state response was also recorded at 0dB HL of intensity, non-specific stimulus and using a masking technique. The study enabled the electrophysiological thresholds to be obtained for each subject of the explored sample. There were no auditory steady-state responses at either 0dB or non-specific stimulus recordings. It was possible to obtain the masking thresholds. A difference was identified between behavioral and electrophysiological thresholds of -6±16, -2±13, 0±22 and -8±18dB at frequencies of 500, 1000, 2000 and 4000Hz respectively. The auditory steady state response seems to be a suitable technique to evaluate the hearing threshold in cochlear implant subjects. Copyright © 2018 Sociedad Española de Otorrinolaringología y Cirugía de Cabeza y Cuello. Publicado por Elsevier España, S.L.U. All rights reserved.

Single-dose and steady-state pharmacokinetics of tenofovir disoproxil fumarate in human immunodeficiency virus-infected children.

PubMed

Hazra, Rohan; Balis, Frank M; Tullio, Antonella N; DeCarlo, Ellen; Worrell, Carol J; Steinberg, Seth M; Flaherty, John F; Yale, Kitty; Poblenz, Marianne; Kearney, Brian P; Zhong, Lijie; Coakley, Dion F; Blanche, Stephane; Bresson, Jean Louis; Zuckerman, Judith A; Zeichner, Steven L

2004-01-01

Tenofovir disoproxil fumarate (DF) is a potent nucleotide analog reverse transcriptase inhibitor approved for the treatment of human immunodeficiency virus (HIV)-infected adults. The single-dose and steady-state pharmacokinetics of tenofovir were evaluated following administration of tenofovir DF in treatment-experienced HIV-infected children requiring a change in antiretroviral therapy. Using increments of tenofovir DF 75-mg tablets, the target dose was 175 mg/m(2); the median administered dose was 208 mg/m(2). Single-dose pharmacokinetics were evaluated in 18 subjects, and the geometric mean area under the concentration-time curve from 0 h to infinity (AUC(0- infinity )) was 2,150 ng. h/ml and the geometric mean maximum concentration (C(max)) was 266 ng/ml. Subsequently, other antiretrovirals were added to each patient's regimen based upon treatment history and baseline viral resistance results. Steady-state pharmacokinetics were evaluated in 16 subjects at week 4. The steady-state, geometric mean AUC for the 24-h dosing interval was 2,920 ng. h/ml and was significantly higher than the AUC(0- infinity ) after the first dose (P = 0.0004). The geometric mean C(max) at steady state was 302 ng/ml. Tenofovir DF was generally very well tolerated. Steady-state tenofovir exposures in children receiving tenofovir DF-containing combination antiretroviral therapy approached values seen in HIV-infected adults (AUC, approximately 3,000 ng. h/ml; C(max), approximately 300 ng/ml) treated with tenofovir DF at 300 mg.

Ultrafiltration technology with a ceramic membrane for reactive dye removal: optimization of membrane performance.

PubMed

Alventosa-deLara, E; Barredo-Damas, S; Alcaina-Miranda, M I; Iborra-Clar, M I

2012-03-30

An ultrafiltration (UF) ceramic membrane was used to decolorize Reactive Black 5 (RB5) solutions at different dye concentrations (50 and 500 mg/L). Transmembrane pressure (TMP) and cross-flow velocity (CFV) were modified to study their influence on initial and steady-state permeate flux (J(p)) and dye rejection (R). Generally, J(p) increased with higher TMP and CFV and lower feed concentration, up to a maximum steady-state J(p) of 266.81 L/(m(2)h), obtained at 3 bar, 3m/s and 50mg/L. However, there was a TMP value (which changed depending on operating CFV and concentration) beyond which slight or no further increase in steady-state J(p) was observed. Similarly, the higher the CFV was, the more slightly the steady-state J(p) increased. Furthermore, the effectiveness of ultrafiltration treatment was evaluated through dye rejection coefficient. The results showed significant dye removals, regardless of the tested conditions, with steady-state R higher than 79.8% for the 50mg/L runs and around 73.2% for the 500 mg/L runs. Finally response surface methodology (RSM) was used to optimize membrane performance. At 50mg/L, a TMP of 4 bar and a CFV of 2.53 m/s were found to be the conditions giving the highest steady-state J(p), 255.86 L/(m(2)h), and the highest R, 95.2% simultaneously. Copyright © 2012 Elsevier B.V. All rights reserved.

Basin stability measure of different steady states in coupled oscillators

NASA Astrophysics Data System (ADS)

Rakshit, Sarbendu; Bera, Bidesh K.; Majhi, Soumen; Hens, Chittaranjan; Ghosh, Dibakar

2017-04-01

In this report, we investigate the stabilization of saddle fixed points in coupled oscillators where individual oscillators exhibit the saddle fixed points. The coupled oscillators may have two structurally different types of suppressed states, namely amplitude death and oscillation death. The stabilization of saddle equilibrium point refers to the amplitude death state where oscillations are ceased and all the oscillators converge to the single stable steady state via inverse pitchfork bifurcation. Due to multistability features of oscillation death states, linear stability theory fails to analyze the stability of such states analytically, so we quantify all the states by basin stability measurement which is an universal nonlocal nonlinear concept and it interplays with the volume of basins of attractions. We also observe multi-clustered oscillation death states in a random network and measure them using basin stability framework. To explore such phenomena we choose a network of coupled Duffing-Holmes and Lorenz oscillators which are interacting through mean-field coupling. We investigate how basin stability for different steady states depends on mean-field density and coupling strength. We also analytically derive stability conditions for different steady states and confirm by rigorous bifurcation analysis.

An optimizing start-up strategy for a bio-methanator.

PubMed

Sbarciog, Mihaela; Loccufier, Mia; Vande Wouwer, Alain

2012-05-01

This paper presents an optimizing start-up strategy for a bio-methanator. The goal of the control strategy is to maximize the outflow rate of methane in anaerobic digestion processes, which can be described by a two-population model. The methodology relies on a thorough analysis of the system dynamics and involves the solution of two optimization problems: steady-state optimization for determining the optimal operating point and transient optimization. The latter is a classical optimal control problem, which can be solved using the maximum principle of Pontryagin. The proposed control law is of the bang-bang type. The process is driven from an initial state to a small neighborhood of the optimal steady state by switching the manipulated variable (dilution rate) from the minimum to the maximum value at a certain time instant. Then the dilution rate is set to the optimal value and the system settles down in the optimal steady state. This control law ensures the convergence of the system to the optimal steady state and substantially increases its stability region. The region of attraction of the steady state corresponding to maximum production of methane is considerably enlarged. In some cases, which are related to the possibility of selecting the minimum dilution rate below a certain level, the stability region of the optimal steady state equals the interior of the state space. Aside its efficiency, which is evaluated not only in terms of biogas production but also from the perspective of treatment of the organic load, the strategy is also characterized by simplicity, being thus appropriate for implementation in real-life systems. Another important advantage is its generality: this technique may be applied to any anaerobic digestion process, for which the acidogenesis and methanogenesis are, respectively, characterized by Monod and Haldane kinetics.

Pharmacokinetic Steady-States Highlight Interesting Target-Mediated Disposition Properties.

PubMed

Gabrielsson, Johan; Peletier, Lambertus A

2017-05-01

In this paper, we derive explicit expressions for the concentrations of ligand L, target R and ligand-target complex RL at steady state for the classical model describing target-mediated drug disposition, in the presence of a constant-rate infusion of ligand. We demonstrate that graphing the steady-state values of ligand, target and ligand-target complex, we obtain striking and often singular patterns, which yield a great deal of insight and understanding about the underlying processes. Deriving explicit expressions for the dependence of L, R and RL on the infusion rate, and displaying graphs of the relations between L, R and RL, we give qualitative and quantitive information for the experimentalist about the processes involved. Understanding target turnover is pivotal for optimising these processes when target-mediated drug disposition (TMDD) prevails. By a combination of mathematical analysis and simulations, we also show that the evolution of the three concentration profiles towards their respective steady-states can be quite complex, especially for lower infusion rates. We also show how parameter estimates obtained from iv bolus studies can be used to derive steady-state concentrations of ligand, target and complex. The latter may serve as a template for future experimental designs.

STEADY-STATE MODEL OF SOLAR WIND ELECTRONS REVISITED

DOE Office of Scientific and Technical Information (OSTI.GOV)

Yoon, Peter H.; Kim, Sunjung; Choe, G. S., E-mail: yoonp@umd.edu

2015-10-20

In a recent paper, Kim et al. put forth a steady-state model for the solar wind electrons. The model assumed local equilibrium between the halo electrons, characterized by an intermediate energy range, and the whistler-range fluctuations. The basic wave–particle interaction is assumed to be the cyclotron resonance. Similarly, it was assumed that a dynamical steady state is established between the highly energetic superhalo electrons and high-frequency Langmuir fluctuations. Comparisons with the measured solar wind electron velocity distribution function (VDF) during quiet times were also made, and reasonable agreements were obtained. In such a model, however, only the steady-state solution for themore » Fokker–Planck type of electron particle kinetic equation was considered. The present paper complements the previous analysis by considering both the steady-state particle and wave kinetic equations. It is shown that the model halo and superhalo electron VDFs, as well as the assumed wave intensity spectra for the whistler and Langmuir fluctuations, approximately satisfy the quasi-linear wave kinetic equations in an approximate sense, thus further validating the local equilibrium model constructed in the paper by Kim et al.« less

Noncontrast-enhanced renal angiography using multiple inversion recovery and alternating TR balanced steady-state free precession.

PubMed

Dong, Hattie Z; Worters, Pauline W; Wu, Holden H; Ingle, R Reeve; Vasanawala, Shreyas S; Nishimura, Dwight G

2013-08-01

Noncontrast-enhanced renal angiography techniques based on balanced steady-state free precession avoid external contrast agents, take advantage of high inherent blood signal from the T 2 / T 1 contrast mechanism, and have short steady-state free precession acquisition times. However, background suppression is limited; inflow times are inflexible; labeling region is difficult to define when tagging arterial flow; and scan times are long. To overcome these limitations, we propose the use of multiple inversion recovery preparatory pulses combined with alternating pulse repetition time balanced steady-state free precession to produce renal angiograms. Multiple inversion recovery uses selective spatial saturation followed by four nonselective inversion recovery pulses to concurrently null a wide range of background T 1 species while allowing for adjustable inflow times; alternating pulse repetition time steady-state free precession maintains vessel contrast and provides added fat suppression. The high level of suppression enables imaging in three-dimensional as well as projective two-dimensional formats, the latter of which has a scan time as short as one heartbeat. In vivo studies at 1.5 T demonstrate the superior vessel contrast of this technique. © 2012 Wiley Periodicals, Inc.

Hybrid Cascading Outage Analysis of Extreme Events with Optimized Corrective Actions

DOE Office of Scientific and Technical Information (OSTI.GOV)

Vallem, Mallikarjuna R.; Vyakaranam, Bharat GNVSR; Holzer, Jesse T.

2017-10-19

Power system are vulnerable to extreme contingencies (like an outage of a major generating substation) that can cause significant generation and load loss and can lead to further cascading outages of other transmission facilities and generators in the system. Some cascading outages are seen within minutes following a major contingency, which may not be captured exclusively using the dynamic simulation of the power system. The utilities plan for contingencies either based on dynamic or steady state analysis separately which may not accurately capture the impact of one process on the other. We address this gap in cascading outage analysis bymore » developing Dynamic Contingency Analysis Tool (DCAT) that can analyze hybrid dynamic and steady state behavior of the power system, including protection system models in dynamic simulations, and simulating corrective actions in post-transient steady state conditions. One of the important implemented steady state processes is to mimic operator corrective actions to mitigate aggravated states caused by dynamic cascading. This paper presents an Optimal Power Flow (OPF) based formulation for selecting corrective actions that utility operators can take during major contingency and thus automate the hybrid dynamic-steady state cascading outage process. The improved DCAT framework with OPF based corrective actions is demonstrated on IEEE 300 bus test system.« less

Modified fluctuation-dissipation and Einstein relation at nonequilibrium steady states

NASA Astrophysics Data System (ADS)

Chaudhuri, Debasish; Chaudhuri, Abhishek

2012-02-01

Starting from the pioneering work of Agarwal [G. S. Agarwal, Zeitschrift für PhysikEPJAFV1434-600110.1007/BF01391621 252, 25 (1972)], we present a unified derivation of a number of modified fluctuation-dissipation relations (MFDR) that relate response to small perturbations around nonequilibrium steady states to steady-state correlations. Using this formalism we show the equivalence of velocity forms of MFDR derived using continuum Langevin and discrete master equation dynamics. The resulting additive correction to the Einstein relation is exemplified using a flashing ratchet model of molecular motors.

Steady-state entanglement activation in optomechanical cavities

NASA Astrophysics Data System (ADS)

Farace, Alessandro; Ciccarello, Francesco; Fazio, Rosario; Giovannetti, Vittorio

2014-02-01

Quantum discord, and related indicators, are raising a relentless interest as a novel paradigm of nonclassical correlations beyond entanglement. Here, we discover a discord-activated mechanism yielding steady-state entanglement production in a realistic continuous-variable setup. This comprises two coupled optomechanical cavities, where the optical modes (OMs) communicate through a fiber. We first use a simplified model to highlight the creation of steady-state discord between the OMs. We show next that such discord improves the level of stationary optomechanical entanglement attainable in the system, making it more robust against temperature and thermal noise.

A mechanical energy analysis of gait initiation

NASA Technical Reports Server (NTRS)

Miller, C. A.; Verstraete, M. C.

1999-01-01

The analysis of gait initiation (the transient state between standing and walking) is an important diagnostic tool to study pathologic gait and to evaluate prosthetic devices. While past studies have quantified mechanical energy of the body during steady-state gait, to date no one has computed the mechanical energy of the body during gait initiation. In this study, gait initiation in seven normal male subjects was studied using a mechanical energy analysis to compute total body energy. The data showed three separate states: quiet standing, gait initiation, and steady-state gait. During gait initiation, the trends in the energy data for the individual segments were similar to those seen during steady-state gait (and in Winter DA, Quanbury AO, Reimer GD. Analysis of instantaneous energy of normal gait. J Biochem 1976;9:253-257), but diminished in amplitude. However, these amplitudes increased to those seen in steady-state during the gait initiation event (GIE), with the greatest increase occurring in the second step due to the push-off of the foundation leg. The baseline level of mechanical energy was due to the potential energy of the individual segments, while the cyclic nature of the data was indicative of the kinetic energy of the particular leg in swing phase during that step. The data presented showed differences in energy trends during gait initiation from those of steady state, thereby demonstrating the importance of this event in the study of locomotion.

Dispersion of a Nanoliter Bolus in Microfluidic Co-Flow.

PubMed

Conway, A J; Saadi, W M; Sinatra, F L; Kowalski, G; Larson, D; Fiering, J

2014-03-01

Microfluidic systems enable reactions and assays on the scale of nanoliters. However, at this scale nonuniformities in sample delivery become significant. To determine the fundamental minimum sample volume required for a particular device, a detailed understanding of mass transport is required. Co-flowing laminar streams are widely used in many devices, but typically only in the steady-state. Because establishing the co-flow steady-state consumes excess sample volume and time, there is a benefit to operating devices in the transient state, which predominates as the volume of the co-flow reactor decreases. Analysis of the co-flow transient has been neglected thus far. In this work we describe the fabrication of a pneumatically controlled microfluidic injector constructed to inject a discrete 50nL bolus into one side of a two-stream co-flow reactor. Using dye for image analysis, injections were performed at a range of flow rates from 0.5-10μL/min, and for comparison we collected the co-flow steady-state data for this range. The results of the image analysis were also compared against theory and simulations for device validation. For evaluation, we established a metric that indicates how well the mass distribution in the bolus injection approximates steady-state co-flow. Using such analysis, transient-state injections can approximate steady-state conditions within predefined errors, allowing straight forward measurements to be performed with reduced reagent consumption.

Effect of Steady-State Faldaprevir on the Pharmacokinetics of Steady-State Methadone and Buprenorphine-Naloxone in Subjects Receiving Stable Addiction Management Therapy

PubMed Central

Joseph, David; Schobelock, Michael J.; Riesenberg, Robert R.; Vince, Bradley D.; Webster, Lynn R.; Adeniji, Abidemi; Elgadi, Mabrouk

2014-01-01

The effects of steady-state faldaprevir on the safety, pharmacokinetics, and pharmacodynamics of steady-state methadone and buprenorphine-naloxone were assessed in 34 healthy male and female subjects receiving stable addiction management therapy. Subjects continued receiving a stable oral dose of either methadone (up to a maximum dose of 180 mg per day) or buprenorphine-naloxone (up to a maximum dose of 24 mg-6 mg per day) and also received oral faldaprevir (240 mg) once daily (QD) for 8 days following a 480-mg loading dose. Serial blood samples were taken for pharmacokinetic analysis. The pharmacodynamics of the opioid maintenance regimens were evaluated by the objective and subjective opioid withdrawal scales. Coadministration of faldaprevir with methadone or buprenorphine-naloxone resulted in geometric mean ratios for the steady-state area under the concentration-time curve from 0 to 24 h (AUC0–24,ss), the steady-state maximum concentration of the drug in plasma (Cmax,ss), and the steady-state concentration of the drug in plasma at 24 h (C24,ss) of 0.92 to 1.18 for (R)-methadone, (S)-methadone, buprenorphine, norbuprenorphine, and naloxone, with 90% confidence intervals including, or very close to including, 1.00 (no effect), suggesting a limited overall effect of faldaprevir. Although individual data showed moderate variability in the exposures between subjects and treatments, there was no evidence of symptoms of opiate overdose or withdrawal either during the coadministration of faldaprevir with methadone or buprenorphine-naloxone or after faldaprevir dosing was stopped. Similar faldaprevir exposures were observed in the methadone- and buprenorphine-naloxone-treated subjects. In conclusion, faldaprevir at 240 mg QD can be coadministered with methadone or buprenorphine-naloxone without dose adjustment, although given the relatively narrow therapeutic windows of these agents, monitoring for opiate overdose and withdrawal may still be appropriate. (This study has been registered at ClinicalTrials.gov under registration no. NCT01637922.) PMID:25385094

A nodally condensed SUPG formulation for free-surface computation of steady-state flows constrained by unilateral contact - Application to rolling

NASA Astrophysics Data System (ADS)

Arora, Shitij; Fourment, Lionel

2018-05-01

In the context of the simulation of industrial hot forming processes, the resultant time-dependent thermo-mechanical multi-field problem (v →,p ,σ ,ɛ ) can be sped up by 10-50 times using the steady-state methods while compared to the conventional incremental methods. Though the steady-state techniques have been used in the past, but only on simple configurations and with structured meshes, and the modern-days problems are in the framework of complex configurations, unstructured meshes and parallel computing. These methods remove time dependency from the equations, but introduce an additional unknown into the problem: the steady-state shape. This steady-state shape x → can be computed as a geometric correction t → on the domain X → by solving the weak form of the steady-state equation v →.n →(t →)=0 using a Streamline Upwind Petrov Galerkin (SUPG) formulation. There exists a strong coupling between the domain shape and the material flow, hence, a two-step fixed point iterative resolution algorithm was proposed that involves (1) the computation of flow field from the resolution of thermo-mechanical equations on a prescribed domain shape and (2) the computation of steady-state shape for an assumed velocity field. The contact equations are introduced in the penalty form both during the flow computation as well as during the free-surface correction. The fact that the contact description is inhomogeneous, i.e., it is defined in the nodal form in the former, and in the weighted residual form in the latter, is assumed to be critical to the convergence of certain problems. Thus, the notion of nodal collocation is invoked in the weak form of the surface correction equation to homogenize the contact coupling. The surface correction algorithm is tested on certain analytical test cases and the contact coupling is tested with some hot rolling problems.

Higher Accuracy of the Lactate Minimum Test Compared to Established Threshold Concepts to Determine Maximal Lactate Steady State in Running.

PubMed

Wahl, Patrick; Zwingmann, Lukas; Manunzio, Christian; Wolf, Jacob; Bloch, Wilhelm

2018-05-18

This study evaluated the accuracy of the lactate minimum test, in comparison to a graded-exercise test and established threshold concepts (OBLA and mDmax) to determine running speed at maximal lactate steady state. Eighteen subjects performed a lactate minimum test, a graded-exercise test (2.4 m·s -1 start,+0.4 m·s -1 every 5 min) and 2 or more constant-speed tests of 30 min to determine running speed at maximal lactate steady state. The lactate minimum test consisted of an initial lactate priming segment, followed by a short recovery phase. Afterwards, the initial load of the subsequent incremental segment was individually determined and was increased by 0.1 m·s -1 every 120 s. Lactate minimum was determined by the lowest measured value (LM abs ) and by a third-order polynomial (LM pol ). The mean difference to maximal lactate steady state was+0.01±0.14 m·s -1 (LM abs ), 0.04±0.15 m·s -1 (LM pol ), -0.06±0.31 m·s 1 (OBLA) and -0.08±0.21 m·s 1 (mDmax). The intraclass correlation coefficient (ICC) between running velocity at maximal lactate steady state and LM abs was highest (ICC=0.964), followed by LM pol (ICC=0.956), mDmax (ICC=0.916) and OBLA (ICC=0.885). Due to the higher accuracy of the lactate minimum test to determine maximal lactate steady state compared to OBLA and mDmax, we suggest the lactate minimum test as a valid and meaningful concept to estimate running velocity at maximal lactate steady state in a single session for moderately up to well-trained athletes. © Georg Thieme Verlag KG Stuttgart · New York.

The Effects of High Intensity Interval Training vs Steady State Training on Aerobic and Anaerobic Capacity

PubMed Central

Foster, Carl; Farland, Courtney V.; Guidotti, Flavia; Harbin, Michelle; Roberts, Brianna; Schuette, Jeff; Tuuri, Andrew; Doberstein, Scott T.; Porcari, John P.

2015-01-01

High intensity interval training (HIIT) has become an increasingly popular form of exercise due to its potentially large effects on exercise capacity and small time requirement. This study compared the effects of two HIIT protocols vs steady-state training on aerobic and anaerobic capacity following 8-weeks of training. Fifty-five untrained college-aged subjects were randomly assigned to three training groups (3x weekly). Steady-state (n = 19) exercised (cycle ergometer) 20 minutes at 90% of ventilatory threshold (VT). Tabata (n = 21) completed eight intervals of 20s at 170% VO2max/10s rest. Meyer (n = 15) completed 13 sets of 30s (20 min) @ 100% PVO2 max/ 60s recovery, average PO = 90% VT. Each subject did 24 training sessions during 8 weeks. Results: There were significant (p < 0.05) increases in VO2max (+19, +18 and +18%) and PPO (+17, +24 and +14%) for each training group, as well as significant increases in peak (+8, + 9 and +5%) & mean (+4, +7 and +6%) power during Wingate testing, but no significant differences between groups. Measures of the enjoyment of the training program indicated that the Tabata protocol was significantly less enjoyable (p < 0.05) than the steady state and Meyer protocols, and that the enjoyment of all protocols declined (p < 0.05) across the duration of the study. The results suggest that although HIIT protocols are time efficient, they are not superior to conventional exercise training in sedentary young adults. Key points Steady state training equivalent to HIIT in untrained students Mild interval training presents very similar physiologic challenge compared to steady state training HIIT (particularly very high intensity variants were less enjoyable than steady state or mild interval training Enjoyment of training decreases across the course of an 8 week experimental training program PMID:26664271

The Effects of High Intensity Interval Training vs Steady State Training on Aerobic and Anaerobic Capacity.

PubMed

Foster, Carl; Farland, Courtney V; Guidotti, Flavia; Harbin, Michelle; Roberts, Brianna; Schuette, Jeff; Tuuri, Andrew; Doberstein, Scott T; Porcari, John P

2015-12-01

High intensity interval training (HIIT) has become an increasingly popular form of exercise due to its potentially large effects on exercise capacity and small time requirement. This study compared the effects of two HIIT protocols vs steady-state training on aerobic and anaerobic capacity following 8-weeks of training. Fifty-five untrained college-aged subjects were randomly assigned to three training groups (3x weekly). Steady-state (n = 19) exercised (cycle ergometer) 20 minutes at 90% of ventilatory threshold (VT). Tabata (n = 21) completed eight intervals of 20s at 170% VO2max/10s rest. Meyer (n = 15) completed 13 sets of 30s (20 min) @ 100% PVO2 max/ 60s recovery, average PO = 90% VT. Each subject did 24 training sessions during 8 weeks. There were significant (p < 0.05) increases in VO2max (+19, +18 and +18%) and PPO (+17, +24 and +14%) for each training group, as well as significant increases in peak (+8, + 9 and +5%) & mean (+4, +7 and +6%) power during Wingate testing, but no significant differences between groups. Measures of the enjoyment of the training program indicated that the Tabata protocol was significantly less enjoyable (p < 0.05) than the steady state and Meyer protocols, and that the enjoyment of all protocols declined (p < 0.05) across the duration of the study. The results suggest that although HIIT protocols are time efficient, they are not superior to conventional exercise training in sedentary young adults. Key pointsSteady state training equivalent to HIIT in untrained studentsMild interval training presents very similar physiologic challenge compared to steady state trainingHIIT (particularly very high intensity variants were less enjoyable than steady state or mild interval trainingEnjoyment of training decreases across the course of an 8 week experimental training program.

Sources of Water to Wells for Transient Cyclic Systems

USGS Publications Warehouse

Reilly, T.E.; Pollock, D.W.

1996-01-01

Many state agencies are currently (1995) developing wellhead protection programs. The thrust of some of these programs is to protect water supplies by determining the areas contributing recharge to water-supply wells and by specifying regulations to minimize the opportunity for contamination of the recharge water by activities at the land surface. The area contributing recharge to a discharging well is the surface area at the water table through which the water flowing to the well entered the ground-water system. In the analyses of ground-water flow systems, steady-state average conditions are commonly used to simplify the problem and make a solution tractable. However, recharge is usually cyclic in nature, with seasonal cycles and longer term climatic cycles. The effect of these cyclic stresses on the area contributing recharge to wells is quantitatively analyzed for a hypothetical alluvial valley aquifer system that is representative of a large class of ground-water systems that are extensively developed for water supply. The analysis shows that, in many cases, these cyclic changes in the recharge rates do not significantly affect the location and size of the areas contributing recharge to wells. The ratio of the mean travel time to the length of the cyclic stress period appears to be an indicator of whether the transient effects of the cyclic stress must be explicitly represented in the analysis of contributing areas to wells. For the cases examined, if the ratio of the mean travel time to the period of the cyclic stress was much greater than one, then the transient area contributing recharge to wells was similar to the area calculated using an average steady-state condition. However, cyclic stresses on systems with ratios less than one do have an effect on the location and size of the areas contributing recharge to wells.

An Operational Definition of the Steady State in Enzyme Kinetics.

ERIC Educational Resources Information Center

Barnsley, E. A.

1990-01-01

The Briggs-Haldane assumption is used as the basis for the development of a kinetic model for enzyme catalysis. An alternative definition of the steady state and examples of realistic mechanisms are provided. (KR)

Vibration testing and analysis using holography

NASA Technical Reports Server (NTRS)

1971-01-01

Time average holography is useful in recording steady state vibrational mode patterns. Phase relationships under steady state conditions are measured with real time holography and special phase shifting techniques. Data from Michelson interferometer verify vibration amplitudes from holographic data.

Limiting Forces on Transit Trucks in Steady-State Curving

DOT National Transportation Integrated Search

1981-05-01

This study develops conservative bounds on wheel/rail forces and flange forces for several types of rigid and flexible trucks in steady-state curving conditions. The approximate analysis presented provides closed-form relations for estimating forces,...

Bifurcations in the theory of current transfer to cathodes of DC discharges and observations of transitions between different modes

NASA Astrophysics Data System (ADS)

Bieniek, M. S.; Santos, D. F. N.; Almeida, P. G. C.; Benilov, M. S.

2018-04-01

General scenarios of transitions between different spot patterns on electrodes of DC gas discharges and their relation to bifurcations of steady-state solutions are analyzed. In the case of cathodes of arc discharges, it is shown that any transition between different modes of current transfer is related to a bifurcation of steady-state solutions. In particular, transitions between diffuse and spot modes on axially symmetric cathodes, frequently observed in the experiment, represent an indication of the presence of pitchfork or fold bifurcations of steady-state solutions. Experimental observations of transitions on cathodes of DC glow microdischarges are analyzed and those potentially related to bifurcations of steady-state solutions are identified. The relevant bifurcations are investigated numerically and the computed patterns are found to conform to those observed in the course of the corresponding transitions in the experiment.

The effect of solute additions on the steady-state creep behavior of dispersion-strengthened aluminum.

NASA Technical Reports Server (NTRS)

Reynolds, G. H.; Lenel, F. V.; Ansell, G. S.

1971-01-01

The effect of solute additions on the steady-state creep behavior of coarse-grained dispersion-strengthened aluminum alloys was studied. Recrystallized dispersion-strengthened solid solutions were found to have stress and temperature sensitivities quite unlike those observed in single-phase solid solutions having the same composition and grain size. The addition of magnesium or copper to the matrix of a recrystallized dispersion-strengthened aluminum causes a decrease in the steady-state creep rate which is much smaller than that caused by similar amounts of solute in single-phase solid solutions. All alloys exhibited essentially a 4.0 power stress exponent in agreement with the model of Ansell and Weertman. The activation energy for steady-state creep in dispersion-strengthened Al-Mg alloys, as well as the stress dependence, was in agreement with the physical model of dislocation climb over the dispersed particles.

Steady-state performance analysis of fiber-optic ring resonator

NASA Astrophysics Data System (ADS)

Seraji, Faramarz E.

2009-01-01

This paper presents a full steady-state analysis of a fiber-optic ring resonator (FORR). Although in the literature the steady-state response of the FORR has been described, a detailed description of the same is not available. As an understanding of the different steady-state characteristics of the FORR is required to appreciate its characteristic response, in this paper, the expressions for the output and loop intensities, phase angles of the fields, conditions for resonance, output and loop intensities at resonance and off-resonance, finesse, and group delay of the FORR are given for different ideal and practical operating conditions of the resonator. Graphical plots of all the above characteristics are given, by highlighting the important results. The information presented in this paper will be helpful in explaining and understanding the pulse response of the resonator used in different applications of FORR.

Poissonian steady states: from stationary densities to stationary intensities.

PubMed

Eliazar, Iddo

2012-10-01

Markov dynamics are the most elemental and omnipresent form of stochastic dynamics in the sciences, with applications ranging from physics to chemistry, from biology to evolution, and from economics to finance. Markov dynamics can be either stationary or nonstationary. Stationary Markov dynamics represent statistical steady states and are quantified by stationary densities. In this paper, we generalize the notion of steady state to the case of general Markov dynamics. Considering an ensemble of independent motions governed by common Markov dynamics, we establish that the entire ensemble attains Poissonian steady states which are quantified by stationary Poissonian intensities and which hold valid also in the case of nonstationary Markov dynamics. The methodology is applied to a host of Markov dynamics, including Brownian motion, birth-death processes, random walks, geometric random walks, renewal processes, growth-collapse dynamics, decay-surge dynamics, Ito diffusions, and Langevin dynamics.

Reduction of Simulation Times for High-Q Structures using the Resonance Equation

DOE PAGES

Hall, Thomas Wesley; Bandaru, Prabhakar R.; Rees, Daniel Earl

2015-11-17

Simulating steady state performance of high quality factor (Q) resonant RF structures is computationally difficult for structures with sizes on the order of more than a few wavelengths because of the long times (on the order of ~ 0.1 ms) required to achieve steady state in comparison with maximum time step that can be used in the simulation (typically, on the order of ~ 1 ps). This paper presents analytical and computational approaches that can be used to accelerate the simulation of the steady state performance of such structures. The basis of the proposed approach is the utilization of amore » larger amplitude signal at the beginning to achieve steady state earlier relative to the nominal input signal. Finally, the methodology for finding the necessary input signal is then discussed in detail, and the validity of the approach is evaluated.« less

Steady-state solutions of a diffusive energy-balance climate model and their stability

NASA Technical Reports Server (NTRS)

Ghil, M.

1975-01-01

A diffusive energy-balance climate model, governed by a nonlinear parabolic partial differential equation, was studied. Three positive steady-state solutions of this equation are found; they correspond to three possible climates of our planet: an interglacial (nearly identical to the present climate), a glacial, and a completely ice-covered earth. Models similar to the main one are considered, and the number of their steady states was determined. All the models have albedo continuously varying with latitude and temperature, and entirely diffusive horizontal heat transfer. The stability under small perturbations of the main model's climates was investigated. A stability criterion is derived, and its application shows that the present climate and the deep freeze are stable, whereas the model's glacial is unstable. The dependence was examined of the number of steady states and of their stability on the average solar radiation.

SUPRATHERMAL SOLAR WIND ELECTRONS AND LANGMUIR TURBULENCE

DOE Office of Scientific and Technical Information (OSTI.GOV)

Kim, Sunjung; Yoon, Peter H.; Choe, G. S.

2016-09-01

The steady-state model recently put forth for the solar wind electron velocity distribution function during quiet time conditions, was originally composed of three population electrons (core, halo, and superhalo) with the core remaining nonresonant with any plasma waves while the halo and superhalo separately maintained steady-state resonance with whistler- and Langmuir-frequency range fluctuations, respectively. However, a recent paper demonstrates that whistler-range fluctuations in fact have no significant contribution. The present paper represents a consummation of the model in that a self-consistent model of the suprathermal electron population, which encompasses both the halo and the superhalo, is constructed solely on themore » basis of the Langmuir fluctuation spectrum. Numerical solutions to steady-state particle and wave kinetic equations are obtained on the basis of an initial trial electron distribution and Langmuir wave spectrum. Such a finding offers a self-consistent explanation for the observed steady-state electron distribution in the solar wind.« less

Poissonian steady states: From stationary densities to stationary intensities

NASA Astrophysics Data System (ADS)

Eliazar, Iddo

2012-10-01

Markov dynamics are the most elemental and omnipresent form of stochastic dynamics in the sciences, with applications ranging from physics to chemistry, from biology to evolution, and from economics to finance. Markov dynamics can be either stationary or nonstationary. Stationary Markov dynamics represent statistical steady states and are quantified by stationary densities. In this paper, we generalize the notion of steady state to the case of general Markov dynamics. Considering an ensemble of independent motions governed by common Markov dynamics, we establish that the entire ensemble attains Poissonian steady states which are quantified by stationary Poissonian intensities and which hold valid also in the case of nonstationary Markov dynamics. The methodology is applied to a host of Markov dynamics, including Brownian motion, birth-death processes, random walks, geometric random walks, renewal processes, growth-collapse dynamics, decay-surge dynamics, Ito diffusions, and Langevin dynamics.

The Effect of Impeller Type on Floc Size and Structure during Shear-Induced Flocculation

PubMed

Spicer; Keller; Pratsinis

1996-12-01

The effect of impeller type and shear rate on the evolution of floc size and structure during shear-induced flocculation of polystyrene particles with aluminum sulfate is investigated by image analysis. One radial flow (six-blade Rushton turbine) and two axial flow (three-blade fluid foil, four-blade 45° pitch) impeller configurations are examined. The steady state average floc size is shown to depend on the frequency of recirculation to the impeller zone and its characteristic velocity gradient. The concepts of fractal geometry are used to characterize the floc structure. For all impellers, the two-dimensional floc fractal dimension, Dpf, increases during floc growth, indicating formation of more open structures. Later on, Dpf levels off at a steady state value as breakage becomes significant and the floc size distribution approaches steady state. The shear rate does not affect the steady state Dpf of the flocs within experimental uncertainty.

Topological properties of a self-assembled electrical network via ab initio calculation

NASA Astrophysics Data System (ADS)

Stephenson, C.; Lyon, D.; Hübler, A.

2017-02-01

Interacting electrical conductors self-assemble to form tree like networks in the presence of applied voltages or currents. Experiments have shown that the degree distribution of the steady state networks are identical over a wide range of network sizes. In this work we develop a new model of the self-assembly process starting from the underlying physical interaction between conductors. In agreement with experimental results we find that for steady state networks, our model predicts that the fraction of endpoints is a constant of 0.252, and the fraction of branch points is 0.237. We find that our model predicts that these scaling properties also hold for the network during the approach to the steady state as well. In addition, we also reproduce the experimental distribution of nodes with a given Strahler number for all steady state networks studied.

The Steady-State Transport of Oxygen through Hemoglobin Solutions

PubMed Central

Keller, K. H.; Friedlander, S. K.

1966-01-01

The steady-state transport of oxygen through hemoglobin solutions was studied to identify the mechanism of the diffusion augmentation observed at low oxygen tensions. A novel technique employing a platinum-silver oxygen electrode was developed to measure the effective diffusion coefficient of oxygen in steady-state transport. The measurements were made over a wider range of hemoglobin and oxygen concentrations than previously reported. Values of the Brownian motion diffusion coefficient of oxygen in hemoglobin solution were obtained as well as measurements of facilitated transport at low oxygen tensions. Transport rates up to ten times greater than ordinary diffusion rates were found. Predictions of oxygen flux were made assuming that the oxyhemoglobin transport coefficient was equal to the Brownian motion diffusivity which was measured in a separate set of experiments. The close correlation between prediction and experiment indicates that the diffusion of oxyhemoglobin is the mechanism by which steady-state oxygen transport is facilitated. PMID:5943608

Realizing steady-state tokamak operation for fusion energy

NASA Astrophysics Data System (ADS)

Luce, T. C.

2011-03-01

Continuous operation of a tokamak for fusion energy has clear engineering advantages but requires conditions beyond those sufficient for a burning plasma. The fusion reactions and external sources must support both the pressure and the current equilibrium without inductive current drive, leading to demands on stability, confinement, current drive, and plasma-wall interactions that exceed those for pulsed tokamaks. These conditions have been met individually, and significant progress has been made in the past decade to realize scenarios where the required conditions are obtained simultaneously. Tokamaks are operated routinely without disruptions near pressure limits, as needed for steady-state operation. Fully noninductive sustainment with more than half of the current from intrinsic currents has been obtained for a resistive time with normalized pressure and confinement approaching those needed for steady-state conditions. One remaining challenge is handling the heat and particle fluxes expected in a steady-state tokamak without compromising the core plasma performance.

Pre-Steady-State Kinetic Analysis of Single-Nucleotide Incorporation by DNA Polymerases

PubMed Central

Su, Yan; Guengerich, F. Peter

2016-01-01

Pre-steady-state kinetic analysis is a powerful and widely used method to obtain multiple kinetic parameters. This protocol provides a step-by-step procedure for pre-steady-state kinetic analysis of single-nucleotide incorporation by a DNA polymerase. It describes the experimental details of DNA substrate annealing, reaction mixture preparation, handling of the RQF-3 rapid quench-flow instrument, denaturing polyacrylamide DNA gel preparation, electrophoresis, quantitation, and data analysis. The core and unique part of this protocol is the rationale for preparation of the reaction mixture (the ratio of the polymerase to the DNA substrate) and methods for conducting pre-steady-state assays on an RQF-3 rapid quench-flow instrument, as well as data interpretation after analysis. In addition, the methods for the DNA substrate annealing and DNA polyacrylamide gel preparation, electrophoresis, quantitation and analysis are suitable for use in other studies. PMID:27248785

Efficient steady-state solver for hierarchical quantum master equations

NASA Astrophysics Data System (ADS)

Zhang, Hou-Dao; Qiao, Qin; Xu, Rui-Xue; Zheng, Xiao; Yan, YiJing

2017-07-01

Steady states play pivotal roles in many equilibrium and non-equilibrium open system studies. Their accurate evaluations call for exact theories with rigorous treatment of system-bath interactions. Therein, the hierarchical equations-of-motion (HEOM) formalism is a nonperturbative and non-Markovian quantum dissipation theory, which can faithfully describe the dissipative dynamics and nonlinear response of open systems. Nevertheless, solving the steady states of open quantum systems via HEOM is often a challenging task, due to the vast number of dynamical quantities involved. In this work, we propose a self-consistent iteration approach that quickly solves the HEOM steady states. We demonstrate its high efficiency with accurate and fast evaluations of low-temperature thermal equilibrium of a model Fenna-Matthews-Olson pigment-protein complex. Numerically exact evaluation of thermal equilibrium Rényi entropies and stationary emission line shapes is presented with detailed discussion.

Marginal states in a cubic autocatalytic reaction

NASA Astrophysics Data System (ADS)

Das, Debojyoti; Ghosh, Pushpita; Ray, Deb Shankar

2011-09-01

Marginal steady state belongs to a special class of states in nonlinear dynamics. To realize this state we consider a cubic autocatalytic reaction A + 2B → 3B in a continuous-stirred-tank-reactor, where the flow rate of the reactant A can be controlled to manipulate the dynamical behavior of the open system. We demonstrate that when the flow rate is weakly noisy the autocatalytic reaction admits of a steady state which is marginal in nature and is surrounded by infinite number of periodic trajectories. When the uncatalyzed reaction A → B is included in the reaction scheme, there exists a marginal steady state which is a critical state corresponding to the point of transition between the flow branch and the equilibrium branch, similar to gas-liquid critical point of transition. This state loses its stability in the weak noise limit.

Influence of the hypercycle on the error threshold: a stochastic approach.

PubMed

García-Tejedor, A; Sanz-Nuño, J C; Olarrea, J; Javier de la Rubia, F; Montero, F

1988-10-21

The role of fluctuations on the error threshold of the hypercycle has been studied by a stochastic approach on a very simplified model. For this model, the master equation was derived and its unique steady state calculated. This state implies the extinction of the system. But the actual time necessary to reach the steady state may be astronomically long whereas for times of experimental interest the system could be near some quasi-stationary states. In order to explore this possibility a Gillespie simulation of the stochastic process has been carried out. These quasi-stationary states correspond to the deterministic steady states of the system. The error threshold shifts towards higher values of the quality factor Q. Moreover, information about the fluctuations around the quasi-stationary states is obtained. The results are discussed in relation to the deterministic states.

A Steady State and Quasi-Steady Interface Between the Generalized Fluid System Simulation Program and the SINDA/G Thermal Analysis Program

NASA Technical Reports Server (NTRS)

Schallhorn, Paul; Majumdar, Alok; Tiller, Bruce

2001-01-01

A general purpose, one dimensional fluid flow code is currently being interfaced with the thermal analysis program SINDA/G. The flow code, GFSSP, is capable of analyzing steady state and transient flow in a complex network. The flow code is capable of modeling several physical phenomena including compressibility effects, phase changes, body forces (such as gravity and centrifugal) and mixture thermodynamics for multiple species. The addition of GFSSP to SINDA/G provides a significant improvement in convective heat transfer modeling for SINDA/G. The interface development is conducted in multiple phases. This paper describes the first phase of the interface which allows for steady and quasisteady (unsteady solid, steady fluid) conjugate heat transfer modeling.

Steady-state entanglement and thermalization of coupled qubits in two common heat baths

NASA Astrophysics Data System (ADS)

Hu, Li-Zhen; Man, Zhong-Xiao; Xia, Yun-Jie

2018-03-01

In this work, we study the steady-state entanglement and thermalization of two coupled qubits embedded in two common baths with different temperatures. The common bath is relevant when the two qubits are difficult to be isolated to only contact with their local baths. With the quantum master equation constructed in the eigenstate representation of the coupled qubits, we have demonstrated the variations of steady-state entanglement with respect to various parameters of the qubits' system in both equilibrium and nonequilibrium cases of the baths. The coupling strength and energy detuning of the qubits as well as the temperature gradient of the baths are found to be beneficial to the enhancement of the entanglement. We note a dark state of the qubits that is free from time-evolution and its initial population can greatly influence the steady-state entanglement. By virtues of effective temperatures, we also study the thermalization of the coupled qubits and their variations with energy detuning.

Steady state numerical solutions for determining the location of MEMS on projectile

NASA Astrophysics Data System (ADS)

Abiprayu, K.; Abdigusna, M. F. F.; Gunawan, P. H.

2018-03-01

This paper is devoted to compare the numerical solutions for the steady and unsteady state heat distribution model on projectile. Here, the best location for installing of the MEMS on the projectile based on the surface temperature is investigated. Numerical iteration methods, Jacobi and Gauss-Seidel have been elaborated to solve the steady state heat distribution model on projectile. The results using Jacobi and Gauss-Seidel are shown identical but the discrepancy iteration cost for each methods is gained. Using Jacobi’s method, the iteration cost is 350 iterations. Meanwhile, using Gauss-Seidel 188 iterations are obtained, faster than the Jacobi’s method. The comparison of the simulation by steady state model and the unsteady state model by a reference is shown satisfying. Moreover, the best candidate for installing MEMS on projectile is observed at pointT(10, 0) which has the lowest temperature for the other points. The temperature using Jacobi and Gauss-Seidel for scenario 1 and 2 atT(10, 0) are 307 and 309 Kelvin respectively.

23 CFR 772.5 - Definitions.

Code of Federal Regulations, 2011 CFR

2011-04-01

... the natural and mechanical sources and human activity, considered to be usually present in a... the period under consideration. (d) L10(h). The hourly value of L10. (e) Leq—the equivalent steady... sound level during the same time period. (f) Leq(h). The hourly value of Leq. (g) Traffic noise impacts...

Using steady-state equations for transient flow calculation in natural gas pipelines

DOE Office of Scientific and Technical Information (OSTI.GOV)

Maddox, R.N.; Zhou, P.

1984-04-02

Maddox and Zhou have extended their technique for calculating the unsteady-state behavior of straight gas pipelines to complex pipeline systems and networks. After developing the steady-state flow rate and pressure profile for each pipe in the network, analysts can perform the transient-state analysis in the real-time step-wise manner described for this technique.

Simultaneous measurement of glucose transport and utilization in the human brain

PubMed Central

Shestov, Alexander A.; Emir, Uzay E.; Kumar, Anjali; Henry, Pierre-Gilles; Seaquist, Elizabeth R.

2011-01-01

Glucose is the primary fuel for brain function, and determining the kinetics of cerebral glucose transport and utilization is critical for quantifying cerebral energy metabolism. The kinetic parameters of cerebral glucose transport, KMt and Vmaxt, in humans have so far been obtained by measuring steady-state brain glucose levels by proton (1H) NMR as a function of plasma glucose levels and fitting steady-state models to these data. Extraction of the kinetic parameters for cerebral glucose transport necessitated assuming a constant cerebral metabolic rate of glucose (CMRglc) obtained from other tracer studies, such as 13C NMR. Here we present new methodology to simultaneously obtain kinetic parameters for glucose transport and utilization in the human brain by fitting both dynamic and steady-state 1H NMR data with a reversible, non-steady-state Michaelis-Menten model. Dynamic data were obtained by measuring brain and plasma glucose time courses during glucose infusions to raise and maintain plasma concentration at ∼17 mmol/l for ∼2 h in five healthy volunteers. Steady-state brain vs. plasma glucose concentrations were taken from literature and the steady-state portions of data from the five volunteers. In addition to providing simultaneous measurements of glucose transport and utilization and obviating assumptions for constant CMRglc, this methodology does not necessitate infusions of expensive or radioactive tracers. Using this new methodology, we found that the maximum transport capacity for glucose through the blood-brain barrier was nearly twofold higher than maximum cerebral glucose utilization. The glucose transport and utilization parameters were consistent with previously published values for human brain. PMID:21791622

Prediction of dendrite arm spacings in unsteady-and steady-state heat flow of unidirectionally solidified binary alloys

NASA Astrophysics Data System (ADS)

Bouchard, Dominique; Kirkaldy, John S.

1997-08-01

Various theoretical dendrite and cell spacing formulas have been tested against experimental data obtained in unsteady- and steady-state heat flow conditions. An iterative assessment strategy satisfactorily overcomes the circumstances that certain constitutive parameters are inadequately established and/or highly variable and that many of the data sets, in terms of gradients, velocities, and/or cooling rates, are unreliable. The accessed unsteady- and steady-state observations on near-terminal binary alloys for primary and secondary spacings were first examined within conventional power law representations, the deduced exponents and confidence limits for each alloy being tabularly recorded. Through this analysis, it became clear that to achieve predictive generality the many constitutive parameters must be included in a rational way, this being achievable only through extant or new theoretical formulations. However, in the case of primary spacings, all formulas, including our own, failed within the unsteady heat flow algorithm while performing adequately within their steady-state context. An earlier untested, heuristically derived steady-state formula after modification, λ _1 = 120 ( {{16X_0^{{1/2}} G_0 (\\varepsilon σ )T_M D}/{(1 - k)mΔ H G R}} )^{{1/2}} ultimately proved its utility in the unsteady regime, and so it is recommended for purposes of predictions for general terminal alloys. For secondary spacings, a Mullins and Sekerka type formula proved from the start to be adequate in both unsteady- and steady-state heat flows, and so it recommends itself in calibrated form, λ _2 = 12π ( {{4σ }/{X_0 (1 - k)^2 Δ H}( {D/R} )^2 } )^{{1/3}}

Energy cost of walking: solving the paradox of steady state in the presence of variable walking speed.

PubMed

Plasschaert, Frank; Jones, Kim; Forward, Malcolm

2009-02-01

Measurement of the energy cost of walking in children with cerebral palsy is used for baseline and outcome assessment. However, such testing relies on the establishment of steady state that is deemed present when oxygen consumption is stable. This is often assumed when walking speed is constant but in practice, speed can and does vary naturally. Whilst constant speed is achievable on a treadmill, this is often impractical clinically, thus rendering an energy cost test to an element of subjectivity. This paper attempts to address this issue by presenting a new method for calculating energy cost of walking that automatically applies a mathematically defined threshold for steady state within a (non-treadmill) walking trial and then strips out all of the non-steady state events within that trial. The method is compared with a generic approach that does not remove non-steady state data but rather uses an average value over a complete walking trial as is often used in the clinical environment. Both methods were applied to the calculation of several energy cost of walking parameters of self-selected walking speed in a cohort of unimpaired subjects and children with cerebral palsy. The results revealed that both methods were strongly correlated for each parameter but showed systematic significant differences. It is suggested that these differences are introduced by the rejection of non-steady state data that would otherwise have incorrectly been incorporated into the calculation of the energy cost of walking indices during self-selected walking with its inherent speed variation.

Reconstructing metabolic flux vectors from extreme pathways: defining the alpha-spectrum.

PubMed

Wiback, Sharon J; Mahadevan, Radhakrishnan; Palsson, Bernhard Ø

2003-10-07

The move towards genome-scale analysis of cellular functions has necessitated the development of analytical (in silico) methods to understand such large and complex biochemical reaction networks. One such method is extreme pathway analysis that uses stoichiometry and thermodynamic irreversibly to define mathematically unique, systemic metabolic pathways. These extreme pathways form the edges of a high-dimensional convex cone in the flux space that contains all the attainable steady state solutions, or flux distributions, for the metabolic network. By definition, any steady state flux distribution can be described as a nonnegative linear combination of the extreme pathways. To date, much effort has been focused on calculating, defining, and understanding these extreme pathways. However, little work has been performed to determine how these extreme pathways contribute to a given steady state flux distribution. This study represents an initial effort aimed at defining how physiological steady state solutions can be reconstructed from a network's extreme pathways. In general, there is not a unique set of nonnegative weightings on the extreme pathways that produce a given steady state flux distribution but rather a range of possible values. This range can be determined using linear optimization to maximize and minimize the weightings of a particular extreme pathway in the reconstruction, resulting in what we have termed the alpha-spectrum. The alpha-spectrum defines which extreme pathways can and cannot be included in the reconstruction of a given steady state flux distribution and to what extent they individually contribute to the reconstruction. It is shown that accounting for transcriptional regulatory constraints can considerably shrink the alpha-spectrum. The alpha-spectrum is computed and interpreted for two cases; first, optimal states of a skeleton representation of core metabolism that include transcriptional regulation, and second for human red blood cell metabolism under various physiological, non-optimal conditions.

Calibration of steady-state car-following models using macroscopic loop detector data.

DOT National Transportation Integrated Search

2010-05-01

The paper develops procedures for calibrating the steady-state component of various car following models using : macroscopic loop detector data. The calibration procedures are developed for a number of commercially available : microscopic traffic sim...

Effects of Wearable Sensor-Based Balance and Gait Training on Balance, Gait, and Functional Performance in Healthy and Patient Populations: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.

PubMed

Gordt, Katharina; Gerhardy, Thomas; Najafi, Bijan; Schwenk, Michael

2018-01-01

Wearable sensors (WS) can accurately measure body motion and provide interactive feedback for supporting motor learning. This review aims to summarize current evidence for the effectiveness of WS training for improving balance, gait and functional performance. A systematic literature search was performed in PubMed, Cochrane, Web of Science, and CINAHL. Randomized controlled trials (RCTs) using a WS exercise program were included. Study quality was examined by the PEDro scale. Meta-analyses were conducted to estimate the effects of WS balance training on the most frequently reported outcome parameters. Eight RCTs were included (Parkinson n = 2, stroke n = 1, Parkinson/stroke n = 1, peripheral neuropathy n = 2, frail older adults n = 1, healthy older adults n = 1). The sample size ranged from n = 20 to 40. Three types of training paradigms were used: (1) static steady-state balance training, (2) dynamic steady-state balance training, which includes gait training, and (3) proactive balance training. RCTs either used one type of training paradigm (type 2: n = 1, type 3: n = 3) or combined different types of training paradigms within their intervention (type 1 and 2: n = 2; all types: n = 2). The meta-analyses revealed significant overall effects of WS training on static steady-state balance outcomes including mediolateral (eyes open: Hedges' g = 0.82, CI: 0.43-1.21; eyes closed: g = 0.57, CI: 0.14-0.99) and anterior-posterior sway (eyes open: g = 0.55, CI: 0.01-1.10; eyes closed: g = 0.44, CI: 0.02-0.86). No effects on habitual gait speed were found in the meta-analysis (g = -0.19, CI: -0.68 to 0.29). Two RCTs reported significant improvements for selected gait variables including single support time, and fast gait speed. One study identified effects on proactive balance (Alternate Step Test), but no effects were found for the Timed Up and Go test and the Berg Balance Scale. Two studies reported positive results on feasibility and usability. Only one study was performed in an unsupervised setting. This review provides evidence for a positive effect of WS training on static steady-state balance in studies with usual care controls and studies with conventional balance training controls. Specific gait parameters and proactive balance measures may also be improved by WS training, yet limited evidence is available. Heterogeneous training paradigms, small sample sizes, and short intervention durations limit the validity of our findings. Larger studies are required for estimating the true potential of WS technology. © 2017 S. Karger AG, Basel.

Pharmacokinetic Study of Intravenous Acetaminophen Administered to Critically Ill Multiple-Trauma Patients at the Usual Dosage and a New Proposal for Administration.

PubMed

Fuster-Lluch, Oscar; Zapater-Hernández, Pedro; Gerónimo-Pardo, Manuel

2017-10-01

The pharmacokinetic profile of intravenous acetaminophen administered to critically ill multiple-trauma patients was studied after 4 consecutive doses of 1 g every 6 hours. Eleven blood samples were taken (predose and 15, 30, 45, 60, 90, 120, 180, 240, 300, and 360 minutes postdose), and urine was collected (during 6-hour intervals between doses) to determine serum and urine acetaminophen concentrations. These were used to calculate the following pharmacokinetic parameters: maximum and minimum concentrations, terminal half-life, area under serum concentration-time curve from 0 to 6 hours, mean residence time, volume of distribution, and serum and renal clearance of acetaminophen. Daily doses of acetaminophen required to obtain steady-state minimum (bolus dosing) and average plasma concentrations (continuous infusion) of 10 μg/mL were calculated (10 μg/mL is the presumed lower limit of the analgesic range). Data are expressed as median [interquartile range]. Twenty-two patients were studied, mostly young (age 44 [34-64] years) males (68%), not obese (weight 78 [70-84] kg). Acetaminophen concentrations and pharmacokinetic parameters were these: maximum concentration 33.6 [25.7-38.7] μg/mL and minimum concentration 0.5 [0.2-2.3] μg/mL, all values below 10 μg/mL and 8 below the detection limit; half-life 1.2 [1.0-1.9] hours; area under the curve for 6 hours 34.7 [29.7-52.7] μg·h/mL; mean residence time 1.8 [1.3-2.6] hours; steady-state volume of distribution 50.8 [42.5-66.5] L; and serum and renal clearance 28.8 [18.9-33.7] L/h and 15 [11-19] mL/min, respectively. Theoretically, daily doses for a steady-state minimum concentration of 10 μg/mL would be 12.2 [7.8-16.4] g/day (166 [112-202] mg/[kg·day]); for an average steady-state concentration of 10 μg/mL, they would be 6.9 [4.5-8.1] g/day (91 [59-111] mg/[kg·day]). In conclusion, administration of acetaminophen at the recommended dosage of 1 g per 6 hours to critically ill multiple-trauma patients yields serum concentrations below 10 μg/mL due to increased elimination. To reach the 10 μg/mL target, and from a strictly pharmacokinetic point of view, continuous infusion may be more feasible than bolus dosing. Such a change in dosing strategy requires appropriate, pharmacokinetic-pharmacodynamic and specific safety study. © 2017, The American College of Clinical Pharmacology.

40 CFR Appendix A to Subpart S of... - Calibrations, Adjustments and Quality Control

Code of Federal Regulations, 2012 CFR

2012-07-01

... average of the pre-test and post-test ambient background levels shall be compared to the permissible...—Calibrations, Adjustments and Quality Control (I) Steady-State Test Equipment States may opt to use transient emission test equipment for steady-state tests and follow the quality control requirements in paragraph (II...

40 CFR Appendix A to Subpart S of... - Calibrations, Adjustments and Quality Control

Code of Federal Regulations, 2010 CFR

2010-07-01

... average of the pre-test and post-test ambient background levels shall be compared to the permissible...—Calibrations, Adjustments and Quality Control (I) Steady-State Test Equipment States may opt to use transient emission test equipment for steady-state tests and follow the quality control requirements in paragraph (II...

40 CFR Appendix A to Subpart S of... - Calibrations, Adjustments and Quality Control

Code of Federal Regulations, 2011 CFR

2011-07-01

... average of the pre-test and post-test ambient background levels shall be compared to the permissible...—Calibrations, Adjustments and Quality Control (I) Steady-State Test Equipment States may opt to use transient emission test equipment for steady-state tests and follow the quality control requirements in paragraph (II...

40 CFR Appendix A to Subpart S of... - Calibrations, Adjustments and Quality Control

Code of Federal Regulations, 2013 CFR

2013-07-01

... average of the pre-test and post-test ambient background levels shall be compared to the permissible...—Calibrations, Adjustments and Quality Control (I) Steady-State Test Equipment States may opt to use transient emission test equipment for steady-state tests and follow the quality control requirements in paragraph (II...

40 CFR Appendix A to Subpart S of... - Calibrations, Adjustments and Quality Control

Code of Federal Regulations, 2014 CFR

2014-07-01

... average of the pre-test and post-test ambient background levels shall be compared to the permissible...—Calibrations, Adjustments and Quality Control (I) Steady-State Test Equipment States may opt to use transient emission test equipment for steady-state tests and follow the quality control requirements in paragraph (II...

On discharge from poppet valves: effects of pressure and system dynamics

NASA Astrophysics Data System (ADS)

Winroth, P. M.; Ford, C. L.; Alfredsson, P. H.

2018-02-01

Simplified flow models are commonly used to design and optimize internal combustion engine systems. The exhaust valves and ports are modelled as straight pipe flows with a corresponding discharge coefficient. The discharge coefficient is usually determined from steady-flow experiments at low pressure ratios and at fixed valve lifts. The inherent assumptions are that the flow through the valve is insensitive to the pressure ratio and may be considered as quasi-steady. The present study challenges these two assumptions through experiments at varying pressure ratios and by comparing measurements of the discharge coefficient obtained under steady and dynamic conditions. Steady flow experiments were performed in a flow bench, whereas the dynamic measurements were performed on a pressurized, 2 l, fixed volume cylinder with one or two moving valves. In the latter experiments an initial pressure (in the range 300-500 kPa) was established whereafter the valve(s) was opened with a lift profile corresponding to different equivalent engine speeds (in the range 800-1350 rpm). The experiments were only concerned with the blowdown phase, i.e. the initial part of the exhaustion process since no piston was simulated. The results show that the process is neither pressure-ratio independent nor quasi-steady. A measure of the "steadiness" has been defined, relating the relative change in the open flow area of the valve to the relative change of flow conditions in the cylinder, a measure that indicates if the process can be regarded as quasi-steady or not.

Regimes of radiative and nonradiative transitions in transport through an electronic system in a photon cavity reaching a steady state

NASA Astrophysics Data System (ADS)

Gudmundsson, Vidar; Jonsson, Thorsteinn H.; Bernodusson, Maria Laura; Abdullah, Nzar Rauf; Sitek, Anna; Goan, Hsi-Sheng; Tang, Chi-Shung; Manolescu, Andrei

2017-01-01

We analyze how a multilevel many-electron system in a photon cavity approaches the steady state when coupled to external leads. When a plunger gate is used to lower cavity photon dressed one- and two-electron states below the bias window defined by the external leads, we can identify one regime with nonradiative transitions dominating the electron transport, and another regime with radiative transitions. Both transitions trap the electrons in the states below the bias bringing the system into a steady state. The order of the two regimes and their relative strength depends on the location of the bias window in the energy spectrum of the system and the initial conditions.

CLASSICAL AREAS OF PHENOMENOLOGY: Temporal behaviour of open-circuit photovoltaic solitons

NASA Astrophysics Data System (ADS)

Zhang, Mei-Zhi; Lu, Ke-Qing; Cheng, Guang-Hua; Li, Ke-Hao; Zhang, Yi-Qi; Zhang, Yu-Hong; Zhang, Yan-Peng

2009-07-01

Based on the time-dependent band-transport model in a photorefractive medium, dark open-circuit photovoltaic (PV) solitons are investigated both theoretically and experimentally. Compared with those of the time-independent models, our theoretical results revealed that quasi-steady-state and steady-state PV solitons can both be obtained. Our results also revealed that when r < 1 (r is the normalized intensity at infinity), the full width at half maximum (FWHM) of solitons decreases monotonically to a constant value; when r > 1, however, the FWHM of solitons first decreases to a minimum before it increases to a constant value. Moreover, the FWHM of steady solitons decreases with increasing intensity ratio for r < 1, and increases with increasing intensity ratio for r > 1. We further observed dark PV solitons in experiments, and recorded their evolution. These results indicated that steady solitons can be observed at low optical power, while quasi-steady-state solitons can only be generated at higher optical power. Good agreement is found between theory and experiment.

Matching Pursuit with Asymmetric Functions for Signal Decomposition and Parameterization

PubMed Central

Spustek, Tomasz; Jedrzejczak, Wiesław Wiktor; Blinowska, Katarzyna Joanna

2015-01-01

The method of adaptive approximations by Matching Pursuit makes it possible to decompose signals into basic components (called atoms). The approach relies on fitting, in an iterative way, functions from a large predefined set (called dictionary) to an analyzed signal. Usually, symmetric functions coming from the Gabor family (sine modulated Gaussian) are used. However Gabor functions may not be optimal in describing waveforms present in physiological and medical signals. Many biomedical signals contain asymmetric components, usually with a steep rise and slower decay. For the decomposition of this kind of signal we introduce a dictionary of functions of various degrees of asymmetry – from symmetric Gabor atoms to highly asymmetric waveforms. The application of this enriched dictionary to Otoacoustic Emissions and Steady-State Visually Evoked Potentials demonstrated the advantages of the proposed method. The approach provides more sparse representation, allows for correct determination of the latencies of the components and removes the "energy leakage" effect generated by symmetric waveforms that do not sufficiently match the structures of the analyzed signal. Additionally, we introduced a time-frequency-amplitude distribution that is more adequate for representation of asymmetric atoms than the conventional time-frequency-energy distribution. PMID:26115480

The Politics of the Steady State

ERIC Educational Resources Information Center

Taylor, Charles

1978-01-01

A steady state society has limits pertaining to population size, non-renewable resources, and production which emits heat or substances into soil, water, or the atmosphere. Respecting these limits means renouncing exponential quantitative growth and accepting a universally available consumption standard. (SW)

Information on estimating local government highway bonds

DOT National Transportation Integrated Search

1973-06-01

The theory of traffic flow following a lane blockage on a multi-lane freeway has been developed. Numerical results have been obtained and are presented both for the steady state case where the traffic density remains constant and the non-steady state...

Mapping current fluctuations of stochastic pumps to nonequilibrium steady states.

PubMed

Rotskoff, Grant M

2017-03-01

We show that current fluctuations in a stochastic pump can be robustly mapped to fluctuations in a corresponding time-independent nonequilibrium steady state. We thus refine a recently proposed mapping so that it ensures equivalence of not only the averages, but also optimal representation of fluctuations in currents and density. Our mapping leads to a natural decomposition of the entropy production in stochastic pumps similar to the "housekeeping" heat. As a consequence of the decomposition of entropy production, the current fluctuations in weakly perturbed stochastic pumps are shown to satisfy a universal bound determined by the steady state entropy production.

Efficiency trade-offs of steady-state methods using FEM and FDM. [iterative solutions for nonlinear flow equations

NASA Technical Reports Server (NTRS)

Gartling, D. K.; Roache, P. J.

1978-01-01

The efficiency characteristics of finite element and finite difference approximations for the steady-state solution of the Navier-Stokes equations are examined. The finite element method discussed is a standard Galerkin formulation of the incompressible, steady-state Navier-Stokes equations. The finite difference formulation uses simple centered differences that are O(delta x-squared). Operation counts indicate that a rapidly converging Newton-Raphson-Kantorovitch iteration scheme is generally preferable over a Picard method. A split NOS Picard iterative algorithm for the finite difference method was most efficient.

Arbitrary Steady-State Solutions with the K-epsilon Model

NASA Technical Reports Server (NTRS)

Rumsey, Christopher L.; Pettersson Reif, B. A.; Gatski, Thomas B.

2006-01-01

Widely-used forms of the K-epsilon turbulence model are shown to yield arbitrary steady-state converged solutions that are highly dependent on numerical considerations such as initial conditions and solution procedure. These solutions contain pseudo-laminar regions of varying size. By applying a nullcline analysis to the equation set, it is possible to clearly demonstrate the reasons for the anomalous behavior. In summary, the degenerate solution acts as a stable fixed point under certain conditions, causing the numerical method to converge there. The analysis also suggests a methodology for preventing the anomalous behavior in steady-state computations.

Response of a small-turboshaft-engine compression system to inlet temperature distortion

NASA Technical Reports Server (NTRS)

Biesiadny, T. J.; Klann, G. A.; Little, J. K.

1984-01-01

An experimental investigation was conducted into the response of a small-turboshaft-engine compression system to steady-state and transient inlet temperature distortions. Transient temperature ramps range from less than 100 K/sec to above 610 K/sec and generated instantaneous temperatures to 420 K above ambient. Steady-state temperature distortion levels were limited by the engine hardware temperature list. Simple analysis of the steady-state distortion data indicated that a particle separator at the engine inlet permitted higher levels of temperature distortion before onset of compressor surge than would be expected without the separator.

Mean field treatment of heterogeneous steady state kinetics

NASA Astrophysics Data System (ADS)

Geva, Nadav; Vaissier, Valerie; Shepherd, James; Van Voorhis, Troy

2017-10-01

We propose a method to quickly compute steady state populations of species undergoing a set of chemical reactions whose rate constants are heterogeneous. Using an average environment in place of an explicit nearest neighbor configuration, we obtain a set of equations describing a single fluctuating active site in the presence of an averaged bath. We apply this Mean Field Steady State (MFSS) method to a model of H2 production on a disordered surface for which the activation energy for the reaction varies from site to site. The MFSS populations quantitatively reproduce the KMC results across the range of rate parameters considered.

Nonthermal steady states after an interaction quench in the Falicov-Kimball model.

PubMed

Eckstein, Martin; Kollar, Marcus

2008-03-28

We present the exact solution of the Falicov-Kimball model after a sudden change of its interaction parameter using nonequilibrium dynamical mean-field theory. For different interaction quenches between the homogeneous metallic and insulating phases the system relaxes to a nonthermal steady state on time scales on the order of variant Planck's over 2pi/bandwidth, showing collapse and revival with an approximate period of h/interaction if the interaction is large. We discuss the reasons for this behavior and provide a statistical description of the final steady state by means of generalized Gibbs ensembles.

Steady state phosphorus mass balance model during hemodialysis based on a pseudo one-compartment kinetic model.

PubMed

Leypoldt, John K; Agar, Baris U; Akonur, Alp; Gellens, Mary E; Culleton, Bruce F

2012-11-01

Mathematical models of phosphorus kinetics and mass balance during hemodialysis are in early development. We describe a theoretical phosphorus steady state mass balance model during hemodialysis based on a novel pseudo one-compartment kinetic model. The steady state mass balance model accounted for net intestinal absorption of phosphorus and phosphorus removal by both dialysis and residual kidney function. Analytical mathematical solutions were derived to describe time-dependent intradialytic and interdialytic serum phosphorus concentrations assuming hemodialysis treatments were performed symmetrically throughout a week. Results from the steady state phosphorus mass balance model are described for thrice weekly hemodialysis treatment prescriptions only. The analysis predicts 1) a minimal impact of dialyzer phosphorus clearance on predialysis serum phosphorus concentration using modern, conventional hemodialysis technology, 2) variability in the postdialysis-to-predialysis phosphorus concentration ratio due to differences in patient-specific phosphorus mobilization, and 3) the importance of treatment time in determining the predialysis serum phosphorus concentration. We conclude that a steady state phosphorus mass balance model can be developed based on a pseudo one-compartment kinetic model and that predictions from this model are consistent with previous clinical observations. The predictions from this mass balance model are theoretical and hypothesis-generating only; additional prospective clinical studies will be required for model confirmation.

Dynamical modelling of haematopoiesis: an integrated view over the system in homeostasis and under perturbation.

PubMed

Manesso, Erica; Teles, José; Bryder, David; Peterson, Carsten

2013-03-06

A very high number of different types of blood cells must be generated daily through a process called haematopoiesis in order to meet the physiological requirements of the organism. All blood cells originate from a population of relatively few haematopoietic stem cells residing in the bone marrow, which give rise to specific progenitors through different lineages. Steady-state dynamics are governed by cell division and commitment rates as well as by population sizes, while feedback components guarantee the restoration of steady-state conditions. In this study, all parameters governing these processes were estimated in a computational model to describe the haematopoietic hierarchy in adult mice. The model consisted of ordinary differential equations and included negative feedback regulation. A combination of literature data, a novel divide et impera approach for steady-state calculations and stochastic optimization allowed one to reduce possible configurations of the system. The model was able to recapitulate the fundamental steady-state features of haematopoiesis and simulate the re-establishment of steady-state conditions after haemorrhage and bone marrow transplantation. This computational approach to the haematopoietic system is novel and provides insight into the dynamics and the nature of possible solutions, with potential applications in both fundamental and clinical research.

Can high fields save the tokamak? The challenge of steady-state operation for low cost compact reactors

NASA Astrophysics Data System (ADS)

Freidberg, Jeffrey; Dogra, Akshunna; Redman, William; Cerfon, Antoine

2016-10-01

The development of high field, high temperature superconductors is thought to be a game changer for the development of fusion power based on the tokamak concept. We test the validity of this assertion for pilot plant scale reactors (Q 10) for two different but related missions: pulsed operation and steady-state operation. Specifically, we derive a set of analytic criteria that determines the basic design parameters of a given fusion reactor mission. As expected there are far more constraints than degrees of freedom in any given design application. However, by defining the mission of the reactor under consideration, we have been able to determine the subset of constraints that drive the design, and calculate the values for the key parameters characterizing the tokamak. Our conclusions are as follows: 1) for pulsed reactors, high field leads to more compact designs and thus cheaper reactors - high B is the way to go; 2) steady-state reactors with H-mode like transport are large, even with high fields. The steady-state constraint is hard to satisfy in compact designs - high B helps but is not enough; 3) I-mode like transport, when combined with high fields, yields relatively compact steady-state reactors - why is there not more research on this favorable transport regime?

Steady-state hydrodynamic instabilities of active liquid crystals: hybrid lattice Boltzmann simulations.

PubMed

Marenduzzo, D; Orlandini, E; Cates, M E; Yeomans, J M

2007-09-01

We report hybrid lattice Boltzmann (HLB) simulations of the hydrodynamics of an active nematic liquid crystal sandwiched between confining walls with various anchoring conditions. We confirm the existence of a transition between a passive phase and an active phase, in which there is spontaneous flow in the steady state. This transition is attained for sufficiently "extensile" rods, in the case of flow-aligning liquid crystals, and for sufficiently "contractile" ones for flow-tumbling materials. In a quasi-one-dimensional geometry, deep in the active phase of flow-aligning materials, our simulations give evidence of hysteresis and history-dependent steady states, as well as of spontaneous banded flow. Flow-tumbling materials, in contrast, rearrange themselves so that only the two boundary layers flow in steady state. Two-dimensional simulations, with periodic boundary conditions, show additional instabilities, with the spontaneous flow appearing as patterns made up of "convection rolls." These results demonstrate a remarkable richness (including dependence on anchoring conditions) in the steady-state phase behavior of active materials, even in the absence of external forcing; they have no counterpart for passive nematics. Our HLB methodology, which combines lattice Boltzmann for momentum transport with a finite difference scheme for the order parameter dynamics, offers a robust and efficient method for probing the complex hydrodynamic behavior of active nematics.

Stable long-term blood formation by stem cells in murine steady-state hematopoiesis.

PubMed

Zavidij, Oksana; Ball, Claudia R; Herbst, Friederike; Oppel, Felix; Fessler, Sylvia; Schmidt, Manfred; von Kalle, Christof; Glimm, Hanno

2012-09-01

Hematopoietic stem cells (HSCs) generate all mature blood cells during the whole lifespan of an individual. However, the clonal contribution of individual HSC and progenitor cells in steady-state hematopoiesis is poorly understood. To investigate the activity of HSCs under steady-state conditions, murine HSC and progenitor cells were genetically marked in vivo by integrating lentiviral vectors (LVs) encoding green fluorescent protein (GFP). Hematopoietic contribution of individual marked clones was monitored by determination of lentiviral integration sites using highly sensitive linear amplification-mediated-polymerase chain reaction. A remarkably stable small proportion of hematopoietic cells expressed GFP in LV-injected animals for up to 24 months, indicating stable marking of murine steady-state hematopoiesis. Analysis of the lentiviral integration sites revealed that multiple hematopoietic clones with both myeloid and lymphoid differentiation potential contributed to long-term hematopoiesis. In contrast to intrafemoral vector injection, intravenous administration of LV preferentially targeted short-lived progenitor cells. Myelosuppressive treatment of mice prior to LV-injection did not affect the marking efficiency. Our study represents the first continuous analysis of clonal behavior of genetically marked hematopoietic cells in an unmanipulated system, providing evidence that multiple clones are simultaneously active in murine steady-state hematopoiesis. Copyright © 2012 AlphaMed Press.

High fidelity quasi steady-state aerodynamic model effects on race vehicle performance predictions using multi-body simulation

NASA Astrophysics Data System (ADS)

Mohrfeld-Halterman, J. A.; Uddin, M.

2016-07-01

We described in this paper the development of a high fidelity vehicle aerodynamic model to fit wind tunnel test data over a wide range of vehicle orientations. We also present a comparison between the effects of this proposed model and a conventional quasi steady-state aerodynamic model on race vehicle simulation results. This is done by implementing both of these models independently in multi-body quasi steady-state simulations to determine the effects of the high fidelity aerodynamic model on race vehicle performance metrics. The quasi steady state vehicle simulation is developed with a multi-body NASCAR Truck vehicle model, and simulations are conducted for three different types of NASCAR race tracks, a short track, a one and a half mile intermediate track, and a higher speed, two mile intermediate race track. For each track simulation, the effects of the aerodynamic model on handling, maximum corner speed, and drive force metrics are analysed. The accuracy of the high-fidelity model is shown to reduce the aerodynamic model error relative to the conventional aerodynamic model, and the increased accuracy of the high fidelity aerodynamic model is found to have realisable effects on the performance metric predictions on the intermediate tracks resulting from the quasi steady-state simulation.

System and method for generating steady state confining current for a toroidal plasma fusion reactor

DOEpatents

Fisch, Nathaniel J.

1981-01-01

A system for generating steady state confining current for a toroidal plasma fusion reactor providing steady-state generation of the thermonuclear power. A dense, hot toroidal plasma is initially prepared with a confining magnetic field with toroidal and poloidal components. Continuous wave RF energy is injected into said plasma to establish a spectrum of traveling waves in the plasma, where the traveling waves have momentum components substantially either all parallel, or all anti-parallel to the confining magnetic field. The injected RF energy is phased to couple to said traveling waves with both a phase velocity component and a wave momentum component in the direction of the plasma traveling wave components. The injected RF energy has a predetermined spectrum selected so that said traveling waves couple to plasma electrons having velocities in a predetermined range .DELTA.. The velocities in the range are substantially greater than the thermal electron velocity of the plasma. In addition, the range is sufficiently broad to produce a raised plateau having width .DELTA. in the plasma electron velocity distribution so that the plateau electrons provide steady-state current to generate a poloidal magnetic field component sufficient for confining the plasma. In steady state operation of the fusion reactor, the fusion power density in the plasma exceeds the power dissipated in the plasma.

System and method for generating steady state confining current for a toroidal plasma fusion reactor

DOEpatents

Bers, Abraham

1981-01-01

A system for generating steady state confining current for a toroidal plasma fusion reactor providing steady-state generation of the thermonuclear power. A dense, hot toroidal plasma is initially prepared with a confining magnetic field with toroidal and poloidal components. Continuous wave RF energy is injected into said plasma to estalish a spectrum of traveling waves in the plasma, where the traveling waves have momentum components substantially either all parallel, or all anti-parallel to the confining magnetic field. The injected RF energy is phased to couple to said traveling waves with both a phase velocity component and a wave momentum component in the direction of the plasma traveling wave components. The injected RF energy has a predetermined spectrum selected so that said traveling waves couple to plasma electrons having velocities in a predetermined range .DELTA.. The velocities in the range are substantially greater than the thermal electron velocity of the plasma. In addition, the range is sufficiently broad to produce a raised plateau having width .DELTA. in the plasma electron velocity distribution so that the plateau electrons provide steady-state current to generate a poloidal magnetic field component sufficient for confining the plasma. In steady state operation of the fusion reactor, the fusion power density in the plasma exceeds the power dissipated inthe plasma.

Visual and auditory steady-state responses in attention-deficit/hyperactivity disorder.

PubMed

Khaleghi, Ali; Zarafshan, Hadi; Mohammadi, Mohammad Reza

2018-05-22

We designed a study to investigate the patterns of the steady-state visual evoked potential (SSVEP) and auditory steady-state response (ASSR) in adolescents with attention-deficit/hyperactivity disorder (ADHD) when performing a motor response inhibition task. Thirty 12- to 18-year-old adolescents with ADHD and 30 healthy control adolescents underwent an electroencephalogram (EEG) examination during steady-state stimuli when performing a stop-signal task. Then, we calculated the amplitude and phase of the steady-state responses in both visual and auditory modalities. Results showed that adolescents with ADHD had a significantly poorer performance in the stop-signal task during both visual and auditory stimuli. The SSVEP amplitude of the ADHD group was larger than that of the healthy control group in most regions of the brain, whereas the ASSR amplitude of the ADHD group was smaller than that of the healthy control group in some brain regions (e.g., right hemisphere). In conclusion, poorer task performance (especially inattention) and neurophysiological results in ADHD demonstrate a possible impairment in the interconnection of the association cortices in the parietal and temporal lobes and the prefrontal cortex. Also, the motor control problems in ADHD may arise from neural deficits in the frontoparietal and occipitoparietal systems and other brain structures such as cerebellum.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Wadge, G.

Some volcanoes erupt magma at average rates which are constant over periods of many years, even through this magma may appear in a complex series of eruptions. This constancy of output is tested by construction of a curve of cumulative volume of erupted magma, which is linear for steady state volcanism, and whose gradient defines the steady state rate Q/sub s/s. The assumption is made that Q/sub s/s is the rate at which magma is supplied to these polygenetic volcanoes. Five general types of eruptive behavior can be distinguished from the cumulative volume studied. These types are interpreted in termsmore » of a simple model of batches of magma rising buoyantly through the crust and interacting with a small-capacity subvolcanic magma reservoir. Recognition of previous steady state behavior at a volcano may enable the cumulative volume curve to be used empirically as a constraint on the timing and volume of the next eruption. The steady state model thus has a limited predictive capability. With the exception of Kilauea (O/sub s/s = 4m/sup 3/ s/sup -1/) all the identified steady state volcanoes have values of Q/sub s/s of a few tenths of one cubic meter per second. These rates are consistent with the minimum flux rates required by theoretical cooling models of batches of magma traversing the crust. The similarity of these Q/sub s/s values of volcanoes (producing basalt, andesite, and dacite magmas) in very different tectonic settings suggests that the common factors of crustal buoyancy forces and the geotherm-controlled cooling rates control the dynamics of magma supply through the crust. Long-term dormancy at active volcanoes may be a manifestation of the steady accumulation of magma in large crustal reservoirs, a process that complements the intermittent periods of steady state output at the surface. This possibility has several implications, the most important of which is that it provides a constraint on the supply rate of new magma to the bases of plutons.« less

FORMULATION OF NON-STEADY-STATE DUST FORMATION PROCESS IN ASTROPHYSICAL ENVIRONMENTS

DOE Office of Scientific and Technical Information (OSTI.GOV)

Nozawa, Takaya; Kozasa, Takashi, E-mail: takaya.nozawa@ipmu.jp

2013-10-10

The non-steady-state formation of small clusters and the growth of grains accompanied by chemical reactions are formulated under the consideration that the collision of key gas species (key molecule) controls the kinetics of dust formation process. The formula allows us to evaluate the size distribution and condensation efficiency of dust formed in astrophysical environments. We apply the formulation to the formation of C and MgSiO{sub 3} grains in the ejecta of supernovae, as an example, to investigate how the non-steady effect influences the formation process, condensation efficiency f{sub con,{sub ∞}}, and average radius a{sub ave,{sub ∞}} of newly formed grainsmore » in comparison with the results calculated with the steady-state nucleation rate. We show that the steady-state nucleation rate is a good approximation if the collision timescale of key molecule τ{sub coll} is much smaller than the timescale τ{sub sat} with which the supersaturation ratio increases; otherwise the effect of the non-steady state becomes remarkable, leading to a lower f{sub con,{sub ∞}} and a larger a{sub ave,{sub ∞}}. Examining the results of calculations, we reveal that the steady-state nucleation rate is applicable if the cooling gas satisfies Λ ≡ τ{sub sat}/τ{sub coll} ∼> 30 during the formation of dust, and find that f{sub con,{sub ∞}} and a{sub ave,{sub ∞}} are uniquely determined by Λ{sub on} at the onset time t{sub on} of dust formation. The approximation formulae for f{sub con,{sub ∞}} and a{sub ave,{sub ∞}} as a function of Λ{sub on} could be useful in estimating the mass and typical size of newly formed grains from observed or model-predicted physical properties not only in supernova ejecta but also in mass-loss winds from evolved stars.« less

Direct in situ observation of metallic glass deformation by real-time nano-scale indentation

NASA Astrophysics Data System (ADS)

Gu, Lin; Xu, Limei; Zhang, Qingsheng; Pan, Deng; Chen, Na; Louzguine-Luzgin, Dmitri V.; Yao, Ke-Fu; Wang, Weihua; Ikuhara, Yuichi

2015-03-01

A common understanding of plastic deformation of metallic glasses (MGs) at room temperature is that such deformation occurs via the formation of runaway shear bands that usually lead to catastrophic failure of MGs. Here we demonstrate that inhomogeneous plastic flow at nanoscale can evolve in a well-controlled manner without further developing of shear bands. It is suggested that the sample undergoes an elasto-plastic transition in terms of quasi steady-state localized shearing. During this transition, embryonic shear localization (ESL) propagates with a very slow velocity of order of ~1 nm/s without the formation of a hot matured shear band. This finding further advances our understanding of the microscopic deformation process associated with the elasto-plastic transition and may shed light on the theoretical development of shear deformation in MGs.

Structured background grids for generation of unstructured grids by advancing front method

NASA Technical Reports Server (NTRS)

Pirzadeh, Shahyar

1991-01-01

A new method of background grid construction is introduced for generation of unstructured tetrahedral grids using the advancing-front technique. Unlike the conventional triangular/tetrahedral background grids which are difficult to construct and usually inadequate in performance, the new method exploits the simplicity of uniform Cartesian meshes and provides grids of better quality. The approach is analogous to solving a steady-state heat conduction problem with discrete heat sources. The spacing parameters of grid points are distributed over the nodes of a Cartesian background grid by interpolating from a few prescribed sources and solving a Poisson equation. To increase the control over the grid point distribution, a directional clustering approach is used. The new method is convenient to use and provides better grid quality and flexibility. Sample results are presented to demonstrate the power of the method.

Moving bed reactor setup to study complex gas-solid reactions.

PubMed

Gupta, Puneet; Velazquez-Vargas, Luis G; Valentine, Charles; Fan, Liang-Shih

2007-08-01

A moving bed scale reactor setup for studying complex gas-solid reactions has been designed in order to obtain kinetic data for scale-up purpose. In this bench scale reactor setup, gas and solid reactants can be contacted in a cocurrent and countercurrent manner at high temperatures. Gas and solid sampling can be performed through the reactor bed with their composition profiles determined at steady state. The reactor setup can be used to evaluate and corroborate model parameters accounting for intrinsic reaction rates in both simple and complex gas-solid reaction systems. The moving bed design allows experimentation over a variety of gas and solid compositions in a single experiment unlike differential bed reactors where the gas composition is usually fixed. The data obtained from the reactor can also be used for direct scale-up of designs for moving bed reactors.

Behavior sensitivities for control augmented structures

NASA Technical Reports Server (NTRS)

Manning, R. A.; Lust, R. V.; Schmit, L. A.

1987-01-01

During the past few years it has been recognized that combining passive structural design methods with active control techniques offers the prospect of being able to find substantially improved designs. These developments have stimulated interest in augmenting structural synthesis by adding active control system design variables to those usually considered in structural optimization. An essential step in extending the approximation concepts approach to control augmented structural synthesis is the development of a behavior sensitivity analysis capability for determining rates of change of dynamic response quantities with respect to changes in structural and control system design variables. Behavior sensitivity information is also useful for man-machine interactive design as well as in the context of system identification studies. Behavior sensitivity formulations for both steady state and transient response are presented and the quality of the resulting derivative information is evaluated.

Some Considerations on the Fundamentals of Chemical Kinetics: Steady State, Quasi-Equilibrium, and Transition State Theory

ERIC Educational Resources Information Center

Perez-Benito, Joaquin F.

2017-01-01

The elementary reaction sequence A ? I ? Products is the simplest mechanism for which the steady-state and quasi-equilibrium kinetic approximations can be applied. The exact integrated solutions for this chemical system allow inferring the conditions that must fulfill the rate constants for the different approximations to hold. A graphical…

Crisis Management.

ERIC Educational Resources Information Center

Hore, Terry

1978-01-01

Problems of "steady state" institutions and techniques of management that have implications for Monash University, Australia are considered. The term "steady state" is used to indicate a lack of additional funds being injected into the system to promote growth and/or development. A trend toward public accountability in higher…

Nonlinear Mechanisms for the Generation of Nearshore Wave Phenomena.

DTIC Science & Technology

1988-04-01

Kadomtsev - Petviashvili equation . Numerical solutions of this equation indicate that steady state is reached only if dispersion is negative; otherwise...leads to a forced Kadomtsev - Petviashvili equation . Numerical solutions of this equation indicate that steady state is reached only if dispersion is

Steady-state inductive spheromak operation

DOEpatents

Janos, A.C.; Jardin, S.C.; Yamada, M.

1985-02-20

The inductively formed spheromak configuration (S-1) can be maintained in a highly stable and controlled fashion. The method described eliminates the restriction to pulsed spheromak plasmas or the use of electrodes for steady-state operation, and, therefore, is a reactor-relevant formation and sustainment method.

Steady-State Fluorescence Anisotropy to Investigate Flavonoids Binding to Proteins

ERIC Educational Resources Information Center

Ingersoll, Christine M.; Strollo, Christen M.

2007-01-01

The steady-state fluorescence anisotropy is employed to study the binding of protein of a model protein, human serum albumin, to a commonly used flavonoid, quercetin. The experiment describes the thermodynamics, as well as the biochemical interactions of such binding effectively.

SAMPLING DURATION DEPENDENCE OF SEMI-CONTINUOUS ORGANIC CARBON MEASUREMENTS ON STEADY STATE SECONDARY ORGANIC AEROSOLS

EPA Science Inventory

Semi-continuous organic carbon concentrations were measured through several experiments of statically generated secondary organic aerosol formed by hydrocarbon + NOx irradiations. Repeated, randomized measurements of these steady state aerosols reveal decreases in the observed c...

78 FR 65161 - Airworthiness Directives; Agusta S.p.A. (Type Certificate Currently Held by AgustaWestland S.p.A...

Federal Register 2010, 2011, 2012, 2013, 2014

2013-10-31

... engine speeds during steady-state operations. These actions are intended to alert pilots to avoid certain... alert pilots to avoid certain engine speeds during steady-state operations, prevent failure of the third...

An adaptive and generalizable closed-loop system for control of medically induced coma and other states of anesthesia

NASA Astrophysics Data System (ADS)

Yang, Yuxiao; Shanechi, Maryam M.

2016-12-01

Objective. Design of closed-loop anesthetic delivery (CLAD) systems is an important topic, particularly for medically induced coma, which needs to be maintained for long periods. Current CLADs for medically induced coma require a separate offline experiment for model parameter estimation, which causes interruption in treatment and is difficult to perform. Also, CLADs may exhibit bias due to inherent time-variation and non-stationarity, and may have large infusion rate variations at steady state. Finally, current CLADs lack theoretical performance guarantees. We develop the first adaptive CLAD for medically induced coma, which addresses these limitations. Further, we extend our adaptive system to be generalizable to other states of anesthesia. Approach. We designed general parametric pharmacodynamic, pharmacokinetic and neural observation models with associated guidelines, and derived a novel adaptive controller. We further penalized large steady-state drug infusion rate variations in the controller. We derived theoretical guarantees that the adaptive system has zero steady-state bias. Using simulations that resembled real time-varying and noisy environments, we tested the closed-loop system for control of two different anesthetic states, burst suppression in medically induced coma and unconsciousness in general anesthesia. Main results. In 1200 simulations, the adaptive system achieved precise control of both anesthetic states despite non-stationarity, time-variation, noise, and no initial parameter knowledge. In both cases, the adaptive system performed close to a baseline system that knew the parameters exactly. In contrast, a non-adaptive system resulted in large steady-state bias and error. The adaptive system also resulted in significantly smaller steady-state infusion rate variations compared to prior systems. Significance. These results have significant implications for clinically viable CLAD design for a wide range of anesthetic states, with potential cost-saving and therapeutic benefits.

An adaptive and generalizable closed-loop system for control of medically induced coma and other states of anesthesia.

PubMed

Yang, Yuxiao; Shanechi, Maryam M

2016-12-01

Design of closed-loop anesthetic delivery (CLAD) systems is an important topic, particularly for medically induced coma, which needs to be maintained for long periods. Current CLADs for medically induced coma require a separate offline experiment for model parameter estimation, which causes interruption in treatment and is difficult to perform. Also, CLADs may exhibit bias due to inherent time-variation and non-stationarity, and may have large infusion rate variations at steady state. Finally, current CLADs lack theoretical performance guarantees. We develop the first adaptive CLAD for medically induced coma, which addresses these limitations. Further, we extend our adaptive system to be generalizable to other states of anesthesia. We designed general parametric pharmacodynamic, pharmacokinetic and neural observation models with associated guidelines, and derived a novel adaptive controller. We further penalized large steady-state drug infusion rate variations in the controller. We derived theoretical guarantees that the adaptive system has zero steady-state bias. Using simulations that resembled real time-varying and noisy environments, we tested the closed-loop system for control of two different anesthetic states, burst suppression in medically induced coma and unconsciousness in general anesthesia. In 1200 simulations, the adaptive system achieved precise control of both anesthetic states despite non-stationarity, time-variation, noise, and no initial parameter knowledge. In both cases, the adaptive system performed close to a baseline system that knew the parameters exactly. In contrast, a non-adaptive system resulted in large steady-state bias and error. The adaptive system also resulted in significantly smaller steady-state infusion rate variations compared to prior systems. These results have significant implications for clinically viable CLAD design for a wide range of anesthetic states, with potential cost-saving and therapeutic benefits.

Current Pulses Momentarily Enhance Thermoelectric Cooling

NASA Technical Reports Server (NTRS)

Snyder, G. Jeffrey; Fleurial, Jean-Pierre; Caillat, Thierry; Chen, Gang; Yang, Rong Gui

2004-01-01

The rates of cooling afforded by thermoelectric (Peltier) devices can be increased for short times by applying pulses of electric current greater than the currents that yield maximum steady-state cooling. It has been proposed to utilize such momentary enhancements of cooling in applications in which diode lasers and other semiconductor devices are required to operate for times of the order of milliseconds at temperatures too low to be easily obtainable in the steady state. In a typical contemplated application, a semiconductor device would be in contact with the final (coldest) somewhat taller stage of a multistage thermoelectric cooler. Steady current would be applied to the stages to produce steady cooling. Pulsed current would then be applied, enhancing the cooling of the top stage momentarily. The principles of operation are straightforward: In a thermoelectric device, the cooling occurs only at a junction at one end of the thermoelectric legs, at a rate proportional to the applied current. However, Joule heating occurs throughout the device at a rate proportional to the current squared. Hence, in the steady state, the steady temperature difference that the device can sustain increases with current only to the point beyond which the Joule heating dominates. If a pulse of current greater than the optimum current (the current for maximum steady cooling) is applied, then the junction becomes momentarily cooled below its lowest steady temperature until thermal conduction brings the resulting pulse of Joule heat to the junction and thereby heats the junction above its lowest steady temperature. A theoretical and experimental study of such transient thermoelectric cooling followed by transient Joule heating in response to current pulses has been performed. The figure presents results from one of the experiments. The study established the essential parameters that characterize the pulse cooling effect, including the minimum temperature achieved, the maximum temperature overshoot, the time to reach minimum temperature, the time while cooled, and the time between pulses. It was found that at large pulse amplitude, the amount of pulse supercooling is about a fourth of the maximum steady-state temperature difference. For the particular thermoelectric device used in one set of the experiments, the practical optimum pulse amplitude was found to be about 3 times the optimum steady-state current. In a further experiment, a pulse cooler was integrated into a small commercial thermoelectric threestage cooler and found to provide several degrees of additional cooling for a time long enough to operate a semiconductor laser in a gas sensor.

Detonation propagation in annular arcs of condensed phase explosives

NASA Astrophysics Data System (ADS)

Ioannou, Eleftherios; Schoch, Stefan; Nikiforakis, Nikolaos; Michael, Louisa

2017-11-01

We present a numerical study of detonation propagation in unconfined explosive charges shaped as an annular arc (rib). Steady detonation in a straight charge propagates at constant speed, but when it enters an annular section, it goes through a transition phase and eventually reaches a new steady state of constant angular velocity. This study examines the speed of the detonation wave along the annular charge during the transition phase and at steady state, as well as its dependence on the dimensions of the annulus. The system is modeled using a recently proposed diffuse-interface formulation which allows for the representation of a two-phase explosive and of an additional inert material. The explosive considered is the polymer-bonded TATB-based LX-17 and is modeled using two Jones-Wilkins-Lee (JWL) equations of state and the ignition and growth reaction rate law. Results show that steady state speeds are in good agreement with experiment. In the transition phase, the evolution of outer detonation speed deviates from the exponential bounded growth function suggested by previous studies. We propose a new description of the transition phase which consists of two regimes. The first regime is caused by local effects at the outer edge of the annulus and leads to a dependence of the outer detonation speed on the angular position along the arc. The second regime is induced by effects originating from the inner edge of the annular charge and leads to the deceleration of the outer detonation until steady state is reached. The study concludes with a parametric study where the dependence of the steady state and the transition phase on the dimensions of the annulus is investigated.

Simultaneous measurement of glucose transport and utilization in the human brain.

PubMed

Shestov, Alexander A; Emir, Uzay E; Kumar, Anjali; Henry, Pierre-Gilles; Seaquist, Elizabeth R; Öz, Gülin

2011-11-01

Glucose is the primary fuel for brain function, and determining the kinetics of cerebral glucose transport and utilization is critical for quantifying cerebral energy metabolism. The kinetic parameters of cerebral glucose transport, K(M)(t) and V(max)(t), in humans have so far been obtained by measuring steady-state brain glucose levels by proton ((1)H) NMR as a function of plasma glucose levels and fitting steady-state models to these data. Extraction of the kinetic parameters for cerebral glucose transport necessitated assuming a constant cerebral metabolic rate of glucose (CMR(glc)) obtained from other tracer studies, such as (13)C NMR. Here we present new methodology to simultaneously obtain kinetic parameters for glucose transport and utilization in the human brain by fitting both dynamic and steady-state (1)H NMR data with a reversible, non-steady-state Michaelis-Menten model. Dynamic data were obtained by measuring brain and plasma glucose time courses during glucose infusions to raise and maintain plasma concentration at ∼17 mmol/l for ∼2 h in five healthy volunteers. Steady-state brain vs. plasma glucose concentrations were taken from literature and the steady-state portions of data from the five volunteers. In addition to providing simultaneous measurements of glucose transport and utilization and obviating assumptions for constant CMR(glc), this methodology does not necessitate infusions of expensive or radioactive tracers. Using this new methodology, we found that the maximum transport capacity for glucose through the blood-brain barrier was nearly twofold higher than maximum cerebral glucose utilization. The glucose transport and utilization parameters were consistent with previously published values for human brain.

Repopulating hematopoietic stem cells from steady-state blood before and after ex vivo culture are enriched in CD34+CD133+CXCR4low fraction.

PubMed

Lapostolle, Véronique; Chevaleyre, Jean; Duchez, Pascale; Rodriguez, Laura; Vlaski-Lafarge, Marija; Sandvig, Ioanna; Brunet de la Grange, Philippe; Ivanovic, Zoran

2018-06-01

Feasibility of ex vivo expansion allows us to consider the steady-state peripheral blood as an alternative source of hematopoietic stem progenitor cells for transplantation when growth factor-induced cell mobilization is contraindicated or inapplicable. Ex vivo expansion dramatically enhances the in vivo reconstituting cell population from steady-state blood. In order to investigate phenotype and the expression of homing molecules, CD34, CD133, CD90, CD45RA, CD26 and CD9 expression was determined on sorted CD34+ cells according to CXCR4 (neg, low, bright) and CD133 expression before and after ex vivo expansion. Hematopoietic stem cell activity was determined in vivo on the basis of hematopoietic repopulation of primary and secondary recipients - NSG immuno-deficient mice. In vivo reconstituting cells in steady-state blood CD34+ cell fraction before expansion belong to the CD133+ population and are CXCR4low or, to a lesser extent, CXCR4neg, while after ex vivo expansion they are contained in only the CD133+CXCR4low cells. The failure of CXCR4bright population to engraft is probably due to the exclusive expression of CD26 by these cells. The limiting-dilution analysis showed that both repopulating cell number and individual proliferative capacity were enhanced by ex vivo expansion. Thus, steady-state peripheral blood cells exhibit a different phenotype compared to mobilized and cord blood ones, as well as to those issued from the bone marrow. This data represent the first phenotypic characterization of steady-state blood cells exhibiting short and long term hematopoietic reconstituting potential, which can be expanded ex vivo, a sine qua non for their subsequent use for transplantation. Copyright © 2018, Ferrata Storti Foundation.

A surface renewal model for unsteady-state mass transfer using the generalized Danckwerts age distribution function.

PubMed

Horvath, Isabelle R; Chatterjee, Siddharth G

2018-05-01

The recently derived steady-state generalized Danckwerts age distribution is extended to unsteady-state conditions. For three different wind speeds used by researchers on air-water heat exchange on the Heidelberg Aeolotron, calculations reveal that the distribution has a sharp peak during the initial moments, but flattens out and acquires a bell-shaped character with process time, with the time taken to attain a steady-state profile being a strong and inverse function of wind speed. With increasing wind speed, the age distribution narrows significantly, its skewness decreases and its peak becomes larger. The mean eddy renewal time increases linearly with process time initially but approaches a final steady-state value asymptotically, which decreases dramatically with increased wind speed. Using the distribution to analyse the transient absorption of a gas into a large body of liquid, assuming negligible gas-side mass-transfer resistance, estimates are made of the gas-absorption and dissolved-gas transfer coefficients for oxygen absorption in water at 25°C for the three different wind speeds. Under unsteady-state conditions, these two coefficients show an inverse behaviour, indicating a heightened accumulation of dissolved gas in the surface elements, especially during the initial moments of absorption. However, the two mass-transfer coefficients start merging together as the steady state is approached. Theoretical predictions of the steady-state mass-transfer coefficient or transfer velocity are in fair agreement (average absolute error of prediction = 18.1%) with some experimental measurements of the same for the nitrous oxide-water system at 20°C that were made in the Heidelberg Aeolotron.

Pure Gaussian state generation via dissipation: a quantum stochastic differential equation approach.

PubMed

Yamamoto, Naoki

2012-11-28

Recently, the complete characterization of a general Gaussian dissipative system having a unique pure steady state was obtained. This result provides a clear guideline for engineering an environment such that the dissipative system has a desired pure steady state such as a cluster state. In this paper, we describe the system in terms of a quantum stochastic differential equation (QSDE) so that the environment channels can be explicitly dealt with. Then, a physical meaning of that characterization, which cannot be seen without the QSDE representation, is clarified; more specifically, the nullifier dynamics of any Gaussian system generating a unique pure steady state is passive. In addition, again based on the QSDE framework, we provide a general and practical method to implement a desired dissipative Gaussian system, which has a structure of quantum state transfer.

Steady state compact toroidal plasma production

DOEpatents

Turner, William C.

1986-01-01

Apparatus and method for maintaining steady state compact toroidal plasmas. A compact toroidal plasma is formed by a magnetized coaxial plasma gun and held in close proximity to the gun electrodes by applied magnetic fields or magnetic fields produced by image currents in conducting walls. Voltage supply means maintains a constant potential across the electrodes producing an increasing magnetic helicity which drives the plasma away from a minimum energy state. The plasma globally relaxes to a new minimum energy state, conserving helicity according to Taylor's relaxation hypothesis, and injecting net helicity into the core of the compact toroidal plasma. Controlling the voltage so as to inject net helicity at a predetermined rate based on dissipative processes maintains or increases the compact toroidal plasma in a time averaged steady state mode.

Polaron effects on the performance of light-harvesting systems: a quantum heat engine perspective

NASA Astrophysics Data System (ADS)

Xu, Dazhi; Wang, Chen; Zhao, Yang; Cao, Jianshu

2016-02-01

We explore energy transfer in a generic three-level system, which is coupled to three non-equilibrium baths. Built on the concept of quantum heat engine, our three-level model describes non-equilibrium quantum processes including light-harvesting energy transfer, nano-scale heat transfer, photo-induced isomerization, and photovoltaics in double quantum-dots. In the context of light-harvesting, the excitation energy is first pumped up by sunlight, then is transferred via two excited states which are coupled to a phonon bath, and finally decays to the reaction center. The efficiency of this process is evaluated by steady state analysis via a polaron-transformed master equation; thus the entire range of the system-phonon coupling strength can be covered. We show that the coupling with the phonon bath not only modifies the steady state, resulting in population inversion, but also introduces a finite steady state coherence which optimizes the energy transfer flux and efficiency. In the strong coupling limit, the steady state coherence disappears and the efficiency recovers the heat engine limit given by Scovil and Schultz-Dubois (1959 Phys. Rev. Lett. 2 262).

Charge carrier thermalization in organic diodes

PubMed Central

van der Kaap, N. J.; Koster, L. J. A.

2016-01-01

Charge carrier mobilities of organic semiconductors are often characterized using steady-state measurements of space charge limited diodes. These measurements assume that charge carriers are in a steady-state equilibrium. In reality, however, energetically hot carriers are introduces by photo-excitation and injection into highly energetic sites from the electrodes. These carriers perturb the equilibrium density of occupied states, and therefore change the overall charge transport properties. In this paper, we look into the effect of energetically hot carriers on the charge transport in organic semiconductors using steady state kinetic Monte Carlo simulations. For injected hot carriers in a typical organic semiconductor, rapid energetic relaxation occurs in the order of tens of nanoseconds, which is much faster than the typical transit time of a charge carrier throught the device. Furthermore, we investigate the impact of photo-generated carriers on the steady-state mobility. For a typical organic voltaic material, an increase in mobility of a factor of 1.1 is found. Therefore, we conclude that the impact of energetically hot carriers on normal device operation is limited. PMID:26791095

Dynamic elementary mode modelling of non-steady state flux data.

PubMed

Folch-Fortuny, Abel; Teusink, Bas; Hoefsloot, Huub C J; Smilde, Age K; Ferrer, Alberto

2018-06-18

A novel framework is proposed to analyse metabolic fluxes in non-steady state conditions, based on the new concept of dynamic elementary mode (dynEM): an elementary mode activated partially depending on the time point of the experiment. Two methods are introduced here: dynamic elementary mode analysis (dynEMA) and dynamic elementary mode regression discriminant analysis (dynEMR-DA). The former is an extension of the recently proposed principal elementary mode analysis (PEMA) method from steady state to non-steady state scenarios. The latter is a discriminant model that permits to identify which dynEMs behave strongly different depending on the experimental conditions. Two case studies of Saccharomyces cerevisiae, with fluxes derived from simulated and real concentration data sets, are presented to highlight the benefits of this dynamic modelling. This methodology permits to analyse metabolic fluxes at early stages with the aim of i) creating reduced dynamic models of flux data, ii) combining many experiments in a single biologically meaningful model, and iii) identifying the metabolic pathways that drive the organism from one state to another when changing the environmental conditions.

Orbit Transfer Vehicle (OTV) advanced expander cycle engine point design study. Volume 3: Engine data summary

NASA Technical Reports Server (NTRS)

1981-01-01

The engine operating characteristics were examined. Inlet pressure effects, tank pressurization effects, steady-state specific impulse, and the steady-state cycle were studied. The propellant flow schematic and operating sequence are presented. Engine hardware drawings are included.

CONTROL OF CRYPTOSPORIDIUM OOCYSTS BY STEADY-STATE CONVENTIONAL TREATMENT

EPA Science Inventory

Pilot-scale experiments have been performed to assess the ability of conventional treatment to control Cryptosporidium oocysts under steady-state conditions. The work was performed with a pilot plant that was designed to minimize flow rates and, as a result, the number of oocyst...

Minimization of a free-energy-like potential for non-equilibrium flow systems at steady state

PubMed Central

Niven, Robert K.

2010-01-01

This study examines a new formulation of non-equilibrium thermodynamics, which gives a conditional derivation of the ‘maximum entropy production’ (MEP) principle for flow and/or chemical reaction systems at steady state. The analysis uses a dimensionless potential function ϕst for non-equilibrium systems, analogous to the free energy concept of equilibrium thermodynamics. Spontaneous reductions in ϕst arise from increases in the ‘flux entropy’ of the system—a measure of the variability of the fluxes—or in the local entropy production; conditionally, depending on the behaviour of the flux entropy, the formulation reduces to the MEP principle. The inferred steady state is also shown to exhibit high variability in its instantaneous fluxes and rates, consistent with the observed behaviour of turbulent fluid flow, heat convection and biological systems; one consequence is the coexistence of energy producers and consumers in ecological systems. The different paths for attaining steady state are also classified. PMID:20368250

On the measurement of 15N-{1H} nuclear Overhauser effects. 2. Effects of the saturation scheme and water signal suppression

PubMed Central

Ferrage, Fabien; Reichel, Amy; Battacharya, Shibani; Cowburn, David; Ghose, Ranajeet

2013-01-01

Measurement of steady-state 15N-{1H} nuclear Overhauser effects forms a cornerstone of most methods to determine protein backbone dynamics from spin-relaxation data, since it is the most reliable probe of very fast motions on the ps-ns timescale. We have, in two previous publications (J. Magn. Reson. 192 (2008), 302-313; J. Am. Chem. Soc. 131 (2009), 6048-6049) reevaluated spin-dynamics during steady-state (or “saturated”) and reference experiments, both of which are required to determine the NOE ratio. Here we assess the performance of several windowed and windowless sequences to achieve effective saturation of protons in steady-state experiments. We also evaluate the influence of the residual water signal due to radiation damping on the NOE ratio. We suggest a recipe that allows one to determine steady-state 15N-{1H} NOE's without artifacts and with the highest possible accuracy. PMID:20951618

Arc plasma generator of atomic driver for steady-state negative ion source.

PubMed

Ivanov, A A; Belchenko, Yu I; Davydenko, V I; Ivanov, I A; Kolmogorov, V V; Listopad, A A; Mishagin, V V; Putvinsky, S V; Shulzhenko, G I; Smirnov, A

2014-02-01

The paper reviews the results of development of steady-state arc-discharge plasma generator with directly heated LaB6 cathode. This arc-discharge plasma generator produces a plasma jet which is to be converted into an atomic one after recombination on a metallic plate. The plate is electrically biased relative to the plasma in order to control the atom energies. Such an intensive jet of hydrogen atoms can be used in negative ion sources for effective production of negative ions on a cesiated surface of plasma grid. All elements of the plasma generator have an augmented water cooling to operate in long pulse mode or in steady state. The thermo-mechanical stresses and deformations of the most critical elements of the plasma generator were determined by simulations. Magnetic field inside the discharge chamber was optimized to reduce the local power loads. The first tests of the steady-state arc plasma generator prototype have performed in long-pulse mode.

Experimental and analytical dynamic flow characteristics of an axial-flow fan from an air cushion landing system model

NASA Technical Reports Server (NTRS)

Thompson, W. C.; Boghani, A. B.; Leland, T. J. W.

1977-01-01

An investigation was conducted to compare the steady-state and dynamic flow characteristics of an axial-flow fan which had been used previously as the air supply fan for some model air cushion landing system studies. Steady-state flow characteristics were determined in the standard manner by using differential orifice pressures for the flow regime from free flow to zero flow. In this same regime, a correlative technique was established so that fan inlet and outlet pressures could be used to measure dynamic flow as created by a rotating damper. Dynamic tests at damper frequencies up to 5 Hz showed very different flow characteristics when compared with steady-state flow, particularly with respect to peak pressures and the pressure-flow relationship at fan stall and unstall. A generalized, rational mathematical fan model was developed based on physical fan parameters and a steady-state flow characteristic. The model showed good correlation with experimental tests at damper frequencies up to 5 Hz.

Torque shudder protection device and method

DOEpatents

King, Robert D.; De Doncker, Rik W. A. A.; Szczesny, Paul M.

1997-01-01

A torque shudder protection device for an induction machine includes a flux command generator for supplying a steady state flux command and a torque shudder detector for supplying a status including a negative status to indicate a lack of torque shudder and a positive status to indicate a presence of torque shudder. A flux adapter uses the steady state flux command and the status to supply a present flux command identical to the steady state flux command for a negative status and different from the steady state flux command for a positive status. A limiter can receive the present flux command, prevent the present flux command from exceeding a predetermined maximum flux command magnitude, and supply the present flux command to a field oriented controller. After determining a critical electrical excitation frequency at which a torque shudder occurs for the induction machine, a flux adjuster can monitor the electrical excitation frequency of the induction machine and adjust a flux command to prevent the monitored electrical excitation frequency from reaching the critical electrical excitation frequency.

Torque shudder protection device and method

DOEpatents

King, R.D.; Doncker, R.W.A.A. De.; Szczesny, P.M.

1997-03-11

A torque shudder protection device for an induction machine includes a flux command generator for supplying a steady state flux command and a torque shudder detector for supplying a status including a negative status to indicate a lack of torque shudder and a positive status to indicate a presence of torque shudder. A flux adapter uses the steady state flux command and the status to supply a present flux command identical to the steady state flux command for a negative status and different from the steady state flux command for a positive status. A limiter can receive the present flux command, prevent the present flux command from exceeding a predetermined maximum flux command magnitude, and supply the present flux command to a field oriented controller. After determining a critical electrical excitation frequency at which a torque shudder occurs for the induction machine, a flux adjuster can monitor the electrical excitation frequency of the induction machine and adjust a flux command to prevent the monitored electrical excitation frequency from reaching the critical electrical excitation frequency. 5 figs.

Steady-state and transient analysis of a squeeze film damper bearing for rotor stability

NASA Technical Reports Server (NTRS)

Barrett, L. E.; Gunter, E. J.

1975-01-01

A study of the steady-state and transient response of the squeeze film damper bearing is presented. Both the steady-state and transient equations for the hydrodynamic bearing forces are derived. The bearing equivalent stiffness and damping coefficients are determined by steady-state equations. These coefficients are used to find the bearing configuration which will provide the optimum support characteristics based on a stability analysis of the rotor-bearing system. The transient analysis of rotor-bearing systems is performed by coupling the bearing and journal equations and integrating forward in time. The effects of unbalance, cavitation, and retainer springs are included in the analysis. Methods of determining the stability of a rotor-bearing system under the influence of aerodynamic forces and internal shaft friction are discussed with emphasis on solving the system characteristic frequency equation and on producing stability maps. It is shown that for optimum stability and low force transmissability the squeeze bearing should operate at an eccentricity ratio epsilon 0.4.

Comparison of NACA 0012 Laminar Flow Solutions: Structured and Unstructured Grid Methods

NASA Technical Reports Server (NTRS)

Swanson, R. C.; Langer, S.

2016-01-01

In this paper we consider the solution of the compressible Navier-Stokes equations for a class of laminar airfoil flows. The principal objective of this paper is to demonstrate that members of this class of laminar flows have steady-state solutions. These laminar airfoil flow cases are often used to evaluate accuracy, stability and convergence of numerical solution algorithms for the Navier-Stokes equations. In recent years, such flows have also been used as test cases for high-order numerical schemes. While generally consistent steady-state solutions have been obtained for these flows using higher order schemes, a number of results have been published with various solutions, including unsteady ones. We demonstrate with two different numerical methods and a range of meshes with a maximum density that exceeds 8 × 106 grid points that steady-state solutions are obtained. Furthermore, numerical evidence is presented that even when solving the equations with an unsteady algorithm, one obtains steady-state solutions.

Effect of external fields in Axelrod's model of social dynamics

NASA Astrophysics Data System (ADS)

Peres, Lucas R.; Fontanari, José F.

2012-09-01

The study of the effects of spatially uniform fields on the steady-state properties of Axelrod's model has yielded plenty of counterintuitive results. Here, we reexamine the impact of this type of field for a selection of parameters such that the field-free steady state of the model is heterogeneous or multicultural. Analyses of both one- and two-dimensional versions of Axelrod's model indicate that the steady state remains heterogeneous regardless of the value of the field strength. Turning on the field leads to a discontinuous decrease on the number of cultural domains, which we argue is due to the instability of zero-field heterogeneous absorbing configurations. We find, however, that spatially nonuniform fields that implement a consensus rule among the neighborhood of the agents enforce homogenization. Although the overall effects of the fields are essentially the same irrespective of the dimensionality of the model, we argue that the dimensionality has a significant impact on the stability of the field-free homogeneous steady state.

A diagonal algorithm for the method of pseudocompressibility. [for steady-state solution to incompressible Navier-Stokes equation

NASA Technical Reports Server (NTRS)

Rogers, S. E.; Kwak, D.; Chang, J. L. C.

1986-01-01

The method of pseudocompressibility has been shown to be an efficient method for obtaining a steady-state solution to the incompressible Navier-Stokes equations. Recent improvements to this method include the use of a diagonal scheme for the inversion of the equations at each iteration. The necessary transformations have been derived for the pseudocompressibility equations in generalized coordinates. The diagonal algorithm reduces the computing time necessary to obtain a steady-state solution by a factor of nearly three. Implicit viscous terms are maintained in the equations, and it has become possible to use fourth-order implicit dissipation. The steady-state solution is unchanged by the approximations resulting from the diagonalization of the equations. Computed results for flow over a two-dimensional backward-facing step and a three-dimensional cylinder mounted normal to a flat plate are presented for both the old and new algorithms. The accuracy and computing efficiency of these algorithms are compared.

Microfluidic circuit analysis II: implications of ion conservation for microchannels connected in series.

PubMed

Biscombe, Christian J C; Davidson, Malcolm R; Harvie, Dalton J E

2012-01-01

A mathematical framework for analysing electrokinetic flow in microchannel networks is outlined. The model is based on conservation of volume and total charge at network junctions, but in contrast to earlier theories also incorporates conservation of ion charge there. The model is applied to mixed pressure-driven/electro-osmotic flows of binary electrolytes through homogeneous microchannels as well as a 4:1:4 contraction-expansion series network. Under conditions of specified volumetric flow rate and ion currents, non-linear steady-state phenomena may arise: when the direction of the net co-ion flux is opposite to the direction of the net volumetric flow, two different fully developed, steady-state flow solutions may be obtained. Model predictions are compared with two-dimensional computational fluid dynamics (CFD) simulations. For systems where two steady states are realisable, the ultimate steady behaviour is shown to depend in part upon the initial state of the system. Copyright © 2011 Elsevier Inc. All rights reserved.

Steady states of OQBM: Central Limit Theorem, Gaussian and non-Gaussian behavior

NASA Astrophysics Data System (ADS)

Petruccione, Francesco; Sinayskiy, Ilya

Open Quantum Brownian Motion (OQBM) describes a Brownian particle with an additional internal quantum degree of freedom. Originally, it was introduced as a scaling limit of Open Quantum Walks (OQWs). Recently, it was noted, that for the model of free OQBM with a two-level system as an internal degree of freedom and decoherent coupling to a dissipative environment, one could use weak external driving of the internal degree of freedom to manipulate the steady-state position of the walker. This observation establishes a useful connection between controllable parameters of the OQBM, e.g. driving strengths and magnitude of detuning, and its steady state properties. Although OQWs satisfy a central limit theorem (CLT), it is known, that OQBM, in general, does not. The aim of this work is to derive steady states for some particular OQBMs and observe possible transitions from Gaussian to non-Gaussian behavior depending on the choice of quantum coin and as a function of diffusion coefficient and dissipation strength.

Viral dynamics in primary HIV-1 infection. Karolinska Institutet Primary HIV Infection Study Group.

PubMed

Lindbäck, S; Karlsson, A C; Mittler, J; Blaxhult, A; Carlsson, M; Briheim, G; Sönnerborg, A; Gaines, H

2000-10-20

To study the natural course of viremia during primary HIV infection (PHI). Eight patients were followed from a median of 5 days from the onset of PHI illness. Plasma HIV-1 RNA levels were measured frequently and the results were fitted to mathematical models. HIV-1 RNA levels were also monitored in nine patients given two reverse transcriptase inhibitors and a protease inhibitor after a median of 7 days from the onset of PHI illness. HIV-1 RNA appeared in the blood during the week preceding onset of PHI illness and increased rapidly during the first viremic phase, reaching a peak at a mean of 7 days after onset of illness. This was followed by a phase of rapidly decreasing levels of HIV-1 RNA to an average of 21 days after onset. Viral density continued to decline thereafter but at a 5- to 50-fold lower rate; a steady-state level was reached at a median of 2 months after onset of PHI. Peak viral density levels correlated significantly with levels measured between days 50 and 600. Initiation of antiretroviral treatment during PHI resulted in rapidly declining levels to below 50 copies/mL. This study demonstrates the kinetic phases of viremia during PHI and indicates two new contributions to the natural history of HIV-1 infection: PHI peak levels correlate with steady-state levels and HIV-1 RNA declines biphasically; an initial rapid decay is usually followed by a slow decay, which is similar to the initial changes seen with antiviral treatment.

A new driving method for piezo deformable mirrors: open loop control and MOAO made easy

NASA Astrophysics Data System (ADS)

Ouattara, Issa; Gach, Jean-Luc; Amram, Philippe

2016-07-01

This paper presents the design and the realisation of a technique to attenuate the hysteresis nonlinear phenomenon of piezoelectric actuators. Piezoelectric actuator are widely utilised for deformable mirrors used for MOAO and power laser beam shaping techniques. The nonlinearities of piezo are usually iteratively compensa- ted using closed-loop set-ups. In open-loop control, the hysteresis and the creep of the piezo cannot be corrected, thus this nonlinearities must be removed or at least minimised. The concept has been demonstrated on high displacement Amplified Piezoelectric Actuators (APA) mounted in a Fabry-Perot interferometer. The hysteresis attenuation technique aims to assist the Fabry-Perots nano-positioning control system to attain its main scientific specification. In such system, each APA has a maximum stroke of 270 μm within a 170 V (-20 V to +150 V) range and is used to position a high reflective mirror plate. The Fabry-Perots nano-positioning control system is specified to limit the APAs positioning steady-state noise to 3nm rms, but the hysteresis limits the positioning accuracy. In order to attenuate hysteresis, a hybrid amplifier circuit built with a high power operational amplifier has been designed and applied for each APA. The experiments results show that the hysteresis effect has almost been eliminated, and consequently the positioning steady-state noise can significantly been reduced. Because of the excellent results of this hybrid amplifier, a patent application has been introduced in June 12, 2015 under number No.1555381 and is being reviewed now.

Development of Fuzzy Logic Controller for Quanser Bench-Top Helicopter

NASA Astrophysics Data System (ADS)

Jafri, M. H.; Mansor, H.; Gunawan, T. S.

2017-11-01

Bench-top helicopter is a laboratory scale helicopter that usually used as a testing bench of the real helicopter behavior. This helicopter is a 3 Degree of Freedom (DOF) helicopter which works by three different axes wshich are elevation, pitch and travel. Thus, fuzzy logic controller has been proposed to be implemented into Quanser bench-top helicopter because of its ability to work with non-linear system. The objective for this project is to design and apply fuzzy logic controller for Quanser bench-top helicopter. Other than that, fuzzy logic controller performance system has been simulated to analyze and verify its behavior over existing PID controller by using Matlab & Simulink software. In this research, fuzzy logic controller has been designed to control the elevation angle. After simulation has been performed, it can be seen that simulation result shows that fuzzy logic elevation control is working for 4°, 5° and 6°. These three angles produce zero steady state error and has a fast response. Other than that, performance comparisons have been performed between fuzzy logic controller and PID controller. Fuzzy logic elevation control has a better performance compared to PID controller where lower percentage overshoot and faster settling time have been achieved in 4°, 5° and 6° step response test. Both controller are have zero steady state error but fuzzy logic controller is managed to produce a better performance in term of settling time and percentage overshoot which make the proposed controller is reliable compared to the existing PID controller.

Shaper-Based Filters for the compensation of the load cell response in dynamic mass measurement

NASA Astrophysics Data System (ADS)

Richiedei, Dario; Trevisani, Alberto

2018-01-01

This paper proposes a novel model-based signal filtering technique for dynamic mass measurement through load cells. Load cells are sensors with an underdamped oscillatory response which usually imposes a long settling time. Real-time filtering is therefore necessary to compensate for such a dynamics and to quickly retrieve the mass of the measurand (which is the steady state value of the load cell response) before the measured signal actually settles. This problem has a big impact on the throughput of industrial weighing machines. In this paper a novel solution to this problem is developed: a model-based filtering technique is proposed to ensure accurate, robust and rapid estimation of the mass of the measurand. The digital filters proposed are referred to as Shaper-Based Filters (SBFs) and are based on the convolution of the load cell output signal with a sequence of few impulses (typically, between 2 and 5). The amplitudes and the instants of application of such impulses are computed through the analytical development of the load cell step response, by imposing the admissible residual oscillation in the steady-state filtered signal and by requiring the desired sensitivity of the filter. The inclusion of robustness specifications tackles effectively the unavoidable uncertainty and variability in the load cell frequency and damping. The effectiveness of the proposed filters is proved experimentally through an industrial set up: the load-cell-instrumented weigh bucket of a multihead weighing machine for packaging. A performance comparison with other benchmark filters is provided and discussed too.

/sup 125/I iothalamate an ideal marker for glomerular filtration

DOE Office of Scientific and Technical Information (OSTI.GOV)

Odlind, B.; Haellgren, R.S.; Sohtell, M.

1985-01-01

The triiodinated angiographic contrast medium, iothalamate (usually labelled /sup 125/I), has been used extensively as a marker for glomerular filtration. The authors have studied the renal handling of /sup 125/I iothalamate (IOT) in vivo and in vitro in several species. In renal cortical slices from chicken, rabbit, rat, and monkey, the tissue-to-medium ratio of IOT was twice that of /sup 51/Cr-EDTA (EDTA) at 37 degrees C; a difference that was abolished at 0 degree C and markedly reduced by added o-iodohippurate or iodipamide. In five chickens the steady-state renal clearance of IOT (CIOT) was twice that of EDTA (CEDTA) ormore » /sup 3/H inulin (C1); a difference that was abolished by administration of 100 mg/kg/hr of novobiocin, an organic anion transport inhibitor. CEDTA was similar to C1 before as well as after transport inhibition. Utilizing the Sperber technique the mean apparent tubular excretion fraction (ATEF) of IOT was 8%, while that of EDTA was 1%. After novobiocin coinfusion (new steady-state) ATEFIOT was significantly reduced and not different from that of EDTA (-1%). In the same animals the total urinary recovery of IOT was 84 and 57% before and after novobiocin, respectively, while corresponding values for EDTA was unchanged by the inhibitor. In seven rats the renal extraction of IOT was reduced from 29 to 17% by coinfusion of probenecid (5 mg/kg/hr). Corresponding extractions were 82 to 34% and 22% (unchanged) for PAH and EDTA, respectively.« less

Assessment of the Absolute Excitatory Level of the Retina by Flicker ERG.

PubMed

Tanimoto, Naoyuki; Seeliger, Mathias W

2018-01-01

Electroretinography (ERG) is important for functional diagnostics of the retina. Types of information about retinal function obtainable by ERG differ depending on recording conditions, e.g., a combination of light stimulus and adaptation. In terms of stimulation, single-flash and flicker stimuli are frequently used because response properties have been well investigated, allowing an assessment of fundamental retinal functionality; for example, how photoreceptors and bipolar cells, including signal transmission between them, are affected under pathological conditions. Usually, ERGs are recorded with a nonzero lower cutoff frequency of amplifiers to avoid certain artifacts, and additionally, responses are averaged over time so that non-event-related signals are cancelled out. However, the improved signal quality is associated with a loss of information. Especially in steady-state flicker ERG, information about the absolute baseline of recordings is missing because the prestimulus baseline is not included on the recording trace as well as because a zero response is obtained in all cases in which the signal baseline stays constant for a sufficient amount of time. In other words, it is impossible to tell from the conventional flicker ERG whether a zero signal is obtained under conditions of maximal or no excitation of the visual system. In this chapter, we describe a direct current ERG protocol (featuring a lower cutoff frequency of zero) with repetitive single flashes mimicking conventional flicker that contains a defined onset. Using this recording protocol, it is possible to assess not only the absolute excitatory level of the retina but also the development of steady-state responses from the single flash response.

A fission-fusion hybrid reactor in steady-state L-mode tokamak configuration with natural uranium

NASA Astrophysics Data System (ADS)

Reed, Mark; Parker, Ronald R.; Forget, Benoit

2012-06-01

This work develops a conceptual design for a fusion-fission hybrid reactor operating in steady-state L-mode tokamak configuration with a subcritical natural or depleted uranium pebble bed blanket. A liquid lithium-lead alloy breeds enough tritium to replenish that consumed by the D-T fusion reaction. The fission blanket augments the fusion power such that the fusion core itself need not have a high power gain, thus allowing for fully non-inductive (steady-state) low confinement mode (L-mode) operation at relatively small physical dimensions. A neutron transport Monte Carlo code models the natural uranium fission blanket. Maximizing the fission power gain while breeding sufficient tritium allows for the selection of an optimal set of blanket parameters, which yields a maximum prudent fission power gain of approximately 7. A 0-D tokamak model suffices to analyze approximate tokamak operating conditions. This fission blanket would allow the fusion component of a hybrid reactor with the same dimensions as ITER to operate in steady-state L-mode very comfortably with a fusion power gain of 6.7 and a thermal fusion power of 2.1 GW. Taking this further can determine the approximate minimum scale for a steady-state L-mode tokamak hybrid reactor, which is a major radius of 5.2 m and an aspect ratio of 2.8. This minimum scale device operates barely within the steady-state L-mode realm with a thermal fusion power of 1.7 GW. Basic thermal hydraulic analysis demonstrates that pressurized helium could cool the pebble bed fission blanket with a flow rate below 10 m/s. The Brayton cycle thermal efficiency is 41%. This reactor, dubbed the Steady-state L-mode non-Enriched Uranium Tokamak Hybrid (SLEUTH), with its very fast neutron spectrum, could be superior to pure fission reactors in terms of breeding fissile fuel and transmuting deleterious fission products. It would likely function best as a prolific plutonium breeder, and the plutonium it produces could actually be more proliferation-resistant than that bred by conventional fast reactors. Furthermore, it can maintain constant total hybrid power output as burnup proceeds by varying the neutron source strength.

Achieving Shared Situational Awareness During Steady-State Operations in New York State: A Model for Success

DTIC Science & Technology

2010-03-01

steady-state conditions, state forest rangers and DEC firefighters monitor seasonal weather conditions and provide open-source reports to several state...NYS Forest Rangers ; NYS Corrections), but the NYSP is the state’s largest direct policing and investigative agency. Given the extensive number of...hole before the spaceship falls close enough to be destroyed. Once mankind figures out how to travel through great distances around the galaxy , this

Steady-states for shear flows of a liquid-crystal model: Multiplicity, stability, and hysteresis

NASA Astrophysics Data System (ADS)

Dorn, Tim; Liu, Weishi

In this work, we study shear flows of a fluid layer between two solid blocks via a liquid-crystal type model proposed in [C.H.A. Cheng, L.H. Kellogg, S. Shkoller, D.L. Turcotte, A liquid-crystal model for friction, Proc. Natl. Acad. Sci. USA 21 (2007) 1-5] for an understanding of frictions. A characterization on the existence and multiplicity of steady-states is provided. Stability issue of the steady-states is examined mainly focusing on bifurcations of zero eigenvalues. The stability result suggests that this simple model exhibits hysteresis, and it is supported by a numerical simulation.

Longtime dynamics of the PDE model for the motion toward light of bacterial colonies

NASA Astrophysics Data System (ADS)

Taranets, R.; Chugunova, M.

2018-03-01

We study stationary solutions and longtime dynamics of the PDE model for cyanobacteria motion, which was recently proposed by Chavy-Waddy and Kolokolnikov (2016 Nonlinearity 29 3174). For different values of the parameter α, which controls the extent of the aggregate, we analyse a family of corresponding steady states and their stability (considering symmetric and non-symmetric cases separately). We derive the rate of convergence toward steady states, show existence of weak nonnegative solutions, and we also discover that the value α = 3 is a special case for this PDE model. Using numerical simulations we compare different regimes and illustrate convergence toward steady states.

Mapping current fluctuations of stochastic pumps to nonequilibrium steady states.

NASA Astrophysics Data System (ADS)

Rotskoff, Grant

We show that current fluctuations in stochastic pumps can be robustly mapped to fluctuations in a corresponding time-independent non-equilibrium steady state. We thus refine a recently proposed mapping so that it ensures equivalence of not only the averages, but also the optimal representation of fluctuations in currents and density. Our mapping leads to a natural decomposition of the entropy production in stochastic pumps, similar to the ``housekeeping'' heat. As a consequence of the decomposition of entropy production, the current fluctuations in weakly perturbed stochastic pumps satisfy a universal bound determined by the steady state entropy production. National Science Foundation Graduate Research Fellowship.

A model for predicting aortic dynamic response to -G sub z impact acceleration.

NASA Technical Reports Server (NTRS)

Advani, S. H.; Tarnay, T. J.; Byars, E. F.; Love, J. S.

1972-01-01

A steady state dynamic response model for the radial motion of the aorta is developed from in vivo pressure-displacement and nerve stimulation experiments on canines. The model represented by a modified Van der Pol wave motion oscillator closely predicts steady state and perturbed response results. The applicability of the steady state canine aortic model to tailward acting impact forces is studied by means of the perturbed phase plane of the oscillator. The backflow through the aortic arch resulting from a specified acceleration-time profile is computed and an analysis for predicting the forced motion aortic response is presented.

The creep properties of dispersion-strengthened silver-gallium oxide alloys.

NASA Technical Reports Server (NTRS)

Lenel, F. V.; Ansell, G. S.; Nazmy, M. Y.

1971-01-01

Steady-state creep rates were measured for two preparations of a dispersion-strengthened alloy of silver with 1 mol % gallium oxide. One preparation, an internally-oxidized type, had a grain size 40 times that of the other preparation, which was a consolidated-powder type of alloy. The temperature and stress dependence of the steady-state creep rate differs widely for the two alloys and must be attributed to the difference in grain size. The activation energy for steady-state creep of the internally-oxidized coarse grained material is near that for self-diffusion of silver, which strongly indicates a creep process controlled by dislocation climb.

A stability theorem for energy-balance climate models

NASA Technical Reports Server (NTRS)

Cahalan, R. F.; North, G. R.

1979-01-01

The paper treats the stability of steady-state solutions of some simple, latitude-dependent, energy-balance climate models. For north-south symmetric solutions of models with an ice-cap-type albedo feedback, and for the sum of horizontal transport and infrared radiation given by a linear operator, it is possible to prove a 'slope stability' theorem, i.e., if the local slope of the steady-state iceline latitude versus solar constant curve is positive (negative) the steady-state solution is stable (unstable). Certain rather weak restrictions on the albedo function and on the heat transport are required for the proof, and their physical basis is discussed.

Global stability of steady states in the classical Stefan problem for general boundary shapes

PubMed Central

Hadžić, Mahir; Shkoller, Steve

2015-01-01

The classical one-phase Stefan problem (without surface tension) allows for a continuum of steady-state solutions, given by an arbitrary (but sufficiently smooth) domain together with zero temperature. We prove global-in-time stability of such steady states, assuming a sufficient degree of smoothness on the initial domain, but without any a priori restriction on the convexity properties of the initial shape. This is an extension of our previous result (Hadžić & Shkoller 2014 Commun. Pure Appl. Math. 68, 689–757 (doi:10.1002/cpa.21522)) in which we studied nearly spherical shapes. PMID:26261359

Descriptive Linear modeling of steady-state visual evoked response

NASA Technical Reports Server (NTRS)

Levison, W. H.; Junker, A. M.; Kenner, K.

1986-01-01

A study is being conducted to explore use of the steady state visual-evoke electrocortical response as an indicator of cognitive task loading. Application of linear descriptive modeling to steady state Visual Evoked Response (VER) data is summarized. Two aspects of linear modeling are reviewed: (1) unwrapping the phase-shift portion of the frequency response, and (2) parsimonious characterization of task-loading effects in terms of changes in model parameters. Model-based phase unwrapping appears to be most reliable in applications, such as manual control, where theoretical models are available. Linear descriptive modeling of the VER has not yet been shown to provide consistent and readily interpretable results.

ANALYZING NUMERICAL ERRORS IN DOMAIN HEAT TRANSPORT MODELS USING THE CVBEM.

USGS Publications Warehouse

Hromadka, T.V.

1987-01-01

Besides providing an exact solution for steady-state heat conduction processes (Laplace-Poisson equations), the CVBEM (complex variable boundary element method) can be used for the numerical error analysis of domain model solutions. For problems where soil-water phase change latent heat effects dominate the thermal regime, heat transport can be approximately modeled as a time-stepped steady-state condition in the thawed and frozen regions, respectively. The CVBEM provides an exact solution of the two-dimensional steady-state heat transport problem, and also provides the error in matching the prescribed boundary conditions by the development of a modeling error distribution or an approximate boundary generation.

Temperature field of dielectric films under continuous ion-beam irradiation

NASA Astrophysics Data System (ADS)

Salikhov, T. Kh.; Abdurahmonov, A. A.

2017-11-01

In the present study, we theoretically examine the formation process of the steady-state temperature field in dielectrics under irradiation with a continuous ion beam in air with allowance for the temperature dependence of thermophysical quantities. Analytical expressions for the temperature field were obtained. An interconnected system of nonlinear algebraic equations for the steady-state temperatures at the front (irradiated) and rear surfaces of the sample, and the steady-state temperature at the interface between the ion-damaged and non-damaged region was obtained; by numerical solution of this system, a nonlinear dependence of the mentioned temperatures on the characteristics of incident ion flux was revealed.

Progress and prospect of true steady state operation with RF

NASA Astrophysics Data System (ADS)

Jacquinot, Jean

2017-10-01

Operation of fusion confinement experiments in full steady state is a major challenge for the development towards fusion energy. Critical to achieving this goal is the availability of actively cooled plasma facing components and auxiliary systems withstanding the very harsh plasma environment. Equally challenging are physics issues related to achieving plasma conditions and current drive efficiency required by reactor plasmas. RF heating and current drive systems have been key instruments for obtaining the progress made until today towards steady state. They hold all the records of long pulse plasma operation both in tokamaks and in stellarators. Nevertheless much progress remains to be made in particular for integrating all the requirements necessary for maintaining in steady state the density and plasma pressure conditions of a reactor. This is an important stated aim of ITER and of devices equipped with superconducting magnets. After considering the present state of the art, this review will address the key issues which remain to be solved both in physics and technology for reaching this goal. They constitute very active subjects of research which will require much dedicated experimentation in the new generation of superconducting devices which are now in operation or becoming close to it.

A controls engineering approach for analyzing airplane input-output characteristics

NASA Technical Reports Server (NTRS)

Arbuckle, P. Douglas

1991-01-01

An engineering approach for analyzing airplane control and output characteristics is presented. State-space matrix equations describing the linear perturbation dynamics are transformed from physical coordinates into scaled coordinates. The scaling is accomplished by applying various transformations to the system to employ prior engineering knowledge of the airplane physics. Two different analysis techniques are then explained. Modal analysis techniques calculate the influence of each system input on each fundamental mode of motion and the distribution of each mode among the system outputs. The optimal steady state response technique computes the blending of steady state control inputs that optimize the steady state response of selected system outputs. Analysis of an example airplane model is presented to demonstrate the described engineering approach.

Quantum spatial propagation of squeezed light in a degenerate parametric amplifier

NASA Technical Reports Server (NTRS)

Deutsch, Ivan H.; Garrison, John C.

1992-01-01

Differential equations which describe the steady state spatial evolution of nonclassical light are established using standard quantum field theoretic techniques. A Schroedinger equation for the state vector of the optical field is derived using the quantum analog of the slowly varying envelope approximation (SVEA). The steady state solutions are those that satisfy the time independent Schroedinger equation. The resulting eigenvalue problem then leads to the spatial propagation equations. For the degenerate parametric amplifier this method shows that the squeezing parameter obey nonlinear differential equations coupled by the amplifier gain and phase mismatch. The solution to these differential equations is equivalent to one obtained from the classical three wave mixing steady state solution to the parametric amplifier with a nondepleted pump.

Performance Assessment of Communication Enhancement Devices TEA HI Threat Headset

DTIC Science & Technology

2015-08-01

while mitigating hearing loss and tinnitus caused by exposure to loud, steady-state and impulsive noise. Active devices should theoretically have...mitigating hearing loss and tinnitus caused by exposure to loud, steady-state and impulsive noise. The general approach for this assessment was to use

TRANSIENT AND STEADY STATE STUDY OF PURE AND MIXED REFRIGERANTS IN A RESIDENTIAL HEAT PUMP

EPA Science Inventory

The report gives results of an experimental and theoretical investigation of the transient and steady state performance of a residential air-conditioning/heat pump (AC/HP) operating with different refrigerants. (NOTE: The project was motivated by environmental concerns related to...

Effect of humoral immunity on HIV-1 dynamics with virus-to-target and infected-to-target infections

NASA Astrophysics Data System (ADS)

Elaiw, A. M.; Raezah, A. A.; Alofi, A. S.

2016-08-01

We consider an HIV-1 dynamics model by incorporating (i) two routes of infection via, respectively, binding of a virus to a receptor on the surface of a target cell to start genetic reactions (virus-to-target infection), and the direct transmission from infected cells to uninfected cells through the concept of virological synapse in vivo (infected-to-target infection); (ii) two types of distributed-time delays to describe the time between the virus or infected cell contacts an uninfected CD4+ T cell and the emission of new active viruses; (iii) humoral immune response, where the HIV-1 particles are attacked by the antibodies that are produced from the B lymphocytes. The existence and stability of all steady states are completely established by two bifurcation parameters, R 0 (the basic reproduction number) and R 1 (the viral reproduction number at the chronic-infection steady state without humoral immune response). By constructing Lyapunov functionals and using LaSalle's invariance principle, we have proven that, if R 0 ≤ 1 , then the infection-free steady state is globally asymptotically stable, if R 1 ≤ 1 < R 0 , then the chronic-infection steady state without humoral immune response is globally asymptotically stable, and if R 1 > 1 , then the chronic-infection steady state with humoral immune response is globally asymptotically stable. We have performed numerical simulations to confirm our theoretical results.

Refined elasticity sampling for Monte Carlo-based identification of stabilizing network patterns.

PubMed

Childs, Dorothee; Grimbs, Sergio; Selbig, Joachim

2015-06-15

Structural kinetic modelling (SKM) is a framework to analyse whether a metabolic steady state remains stable under perturbation, without requiring detailed knowledge about individual rate equations. It provides a representation of the system's Jacobian matrix that depends solely on the network structure, steady state measurements, and the elasticities at the steady state. For a measured steady state, stability criteria can be derived by generating a large number of SKMs with randomly sampled elasticities and evaluating the resulting Jacobian matrices. The elasticity space can be analysed statistically in order to detect network positions that contribute significantly to the perturbation response. Here, we extend this approach by examining the kinetic feasibility of the elasticity combinations created during Monte Carlo sampling. Using a set of small example systems, we show that the majority of sampled SKMs would yield negative kinetic parameters if they were translated back into kinetic models. To overcome this problem, a simple criterion is formulated that mitigates such infeasible models. After evaluating the small example pathways, the methodology was used to study two steady states of the neuronal TCA cycle and the intrinsic mechanisms responsible for their stability or instability. The findings of the statistical elasticity analysis confirm that several elasticities are jointly coordinated to control stability and that the main source for potential instabilities are mutations in the enzyme alpha-ketoglutarate dehydrogenase. © The Author 2015. Published by Oxford University Press.

Effect of age and single versus multiple dose pharmacokinetics of letrozole (Femara) in breast cancer patients.

PubMed

Pfister, C U; Martoni, A; Zamagni, C; Lelli, G; De Braud, F; Souppart, C; Duval, M; Hornberger, U

2001-07-01

Letrozole (trademark Femara) is a new orally active, potent and selective aromatase inhibitor for the hormonal treatment of advanced breast cancer in postmenopausal women. The pharmacokinetics of letrozole and the suppression of peripheral estrogens were studied in 28 breast cancer patients after a single dose and at steady state. The pharmacokinetics of two distinct age groups (> or =50, < or =65, N=15 and > or =70 years old, N=9) were compared. There were no significant differences in area under the curve (AUC) or terminal half-life between the two age groups neither after a single dose nor at steady state. However, when comparing steady state to single dose kinetics, half-life and AUC increased significantly by 42% (90% CI: 1.13, 1.78) and 28% (90% CI: 1.12, 1.47), respectively. This deviation from linearity was probably due to a partial saturation or auto-inhibition of the dominant metabolic clearance mechanism of letrozole. At steady state, approximately 70% of the administered dose was excreted in urine as unchanged letrozole (6.0+/-3.8%) or as the glucuronide of the major, pharmacologically inactive metabolite CGP44645 (64.2+/-22.7%). A single dose of letrozole caused suppression of serum estrogen levels close to the quantification limit of the assay. No difference between single dose suppression and suppression at steady state could be detected. Copyright 2001 John Wiley & Sons, Ltd.

Efficient Decoding With Steady-State Kalman Filter in Neural Interface Systems

PubMed Central

Malik, Wasim Q.; Truccolo, Wilson; Brown, Emery N.; Hochberg, Leigh R.

2011-01-01

The Kalman filter is commonly used in neural interface systems to decode neural activity and estimate the desired movement kinematics. We analyze a low-complexity Kalman filter implementation in which the filter gain is approximated by its steady-state form, computed offline before real-time decoding commences. We evaluate its performance using human motor cortical spike train data obtained from an intracortical recording array as part of an ongoing pilot clinical trial. We demonstrate that the standard Kalman filter gain converges to within 95% of the steady-state filter gain in 1.5 ± 0.5 s (mean ± s.d.). The difference in the intended movement velocity decoded by the two filters vanishes within 5 s, with a correlation coefficient of 0.99 between the two decoded velocities over the session length. We also find that the steady-state Kalman filter reduces the computational load (algorithm execution time) for decoding the firing rates of 25 ± 3 single units by a factor of 7.0 ± 0.9. We expect that the gain in computational efficiency will be much higher in systems with larger neural ensembles. The steady-state filter can thus provide substantial runtime efficiency at little cost in terms of estimation accuracy. This far more efficient neural decoding approach will facilitate the practical implementation of future large-dimensional, multisignal neural interface systems. PMID:21078582

Computing the structural influence matrix for biological systems.

PubMed

Giordano, Giulia; Cuba Samaniego, Christian; Franco, Elisa; Blanchini, Franco

2016-06-01

We consider the problem of identifying structural influences of external inputs on steady-state outputs in a biological network model. We speak of a structural influence if, upon a perturbation due to a constant input, the ensuing variation of the steady-state output value has the same sign as the input (positive influence), the opposite sign (negative influence), or is zero (perfect adaptation), for any feasible choice of the model parameters. All these signs and zeros can constitute a structural influence matrix, whose (i, j) entry indicates the sign of steady-state influence of the jth system variable on the ith variable (the output caused by an external persistent input applied to the jth variable). Each entry is structurally determinate if the sign does not depend on the choice of the parameters, but is indeterminate otherwise. In principle, determining the influence matrix requires exhaustive testing of the system steady-state behaviour in the widest range of parameter values. Here we show that, in a broad class of biological networks, the influence matrix can be evaluated with an algorithm that tests the system steady-state behaviour only at a finite number of points. This algorithm also allows us to assess the structural effect of any perturbation, such as variations of relevant parameters. Our method is applied to nontrivial models of biochemical reaction networks and population dynamics drawn from the literature, providing a parameter-free insight into the system dynamics.

Analysis of Operating Principles with S-system Models

PubMed Central

Lee, Yun; Chen, Po-Wei; Voit, Eberhard O.

2011-01-01

Operating principles address general questions regarding the response dynamics of biological systems as we observe or hypothesize them, in comparison to a priori equally valid alternatives. In analogy to design principles, the question arises: Why are some operating strategies encountered more frequently than others and in what sense might they be superior? It is at this point impossible to study operation principles in complete generality, but the work here discusses the important situation where a biological system must shift operation from its normal steady state to a new steady state. This situation is quite common and includes many stress responses. We present two distinct methods for determining different solutions to this task of achieving a new target steady state. Both methods utilize the property of S-system models within Biochemical Systems Theory (BST) that steady-states can be explicitly represented as systems of linear algebraic equations. The first method uses matrix inversion, a pseudo-inverse, or regression to characterize the entire admissible solution space. Operations on the basis of the solution space permit modest alterations of the transients toward the target steady state. The second method uses standard or mixed integer linear programming to determine admissible solutions that satisfy criteria of functional effectiveness, which are specified beforehand. As an illustration, we use both methods to characterize alternative response patterns of yeast subjected to heat stress, and compare them with observations from the literature. PMID:21377479

Chemostat studies of bacteriophage M13 infected Escherichia coli JM109 for continuous ssDNA production.

PubMed

Kick, Benjamin; Behler, Karl Lorenz; Severin, Timm Steffen; Weuster-Botz, Dirk

2017-09-20

Steady state studies in a chemostat enable the control of microbial growth rate at defined reaction conditions. The effects of bacteriophage M13 infection on maximum growth rate of Escherichia coli JM109 were studied in parallel operated chemostats on a milliliter-scale to analyze the steady state kinetics of phage production. The bacteriophage infection led to a decrease in maximum specific growth rate of 15% from 0.74h -1 to 0.63h -1 . Under steady state conditions, a constant cell specific ssDNA formation rate of 0.15±0.004 mg ssDNA g CDW -1 h -1 was observed, which was independent of the growth rate. Using the estimated kinetic parameters for E. coli infected with bacteriophage M13, the ssDNA concentration in the steady state could be predicted as function of the dilution rate and the glucose concentration in the substrate. Scalability of milliliter-scale data was approved by steady state studies on a liter-scale at a selected dilution rate. An ssDNA space-time yield of 5.7mgL -1 h -1 was achieved with increased glucose concentration in the feed at a dilution rate of 0.3h -1 , which is comparable to established fed-batch fermentation with bacteriophage M13 for ssDNA production. Copyright © 2017 Elsevier B.V. All rights reserved.

Universal Poisson Statistics of mRNAs with Complex Decay Pathways.

PubMed

Thattai, Mukund

2016-01-19

Messenger RNA (mRNA) dynamics in single cells are often modeled as a memoryless birth-death process with a constant probability per unit time that an mRNA molecule is synthesized or degraded. This predicts a Poisson steady-state distribution of mRNA number, in close agreement with experiments. This is surprising, since mRNA decay is known to be a complex process. The paradox is resolved by realizing that the Poisson steady state generalizes to arbitrary mRNA lifetime distributions. A mapping between mRNA dynamics and queueing theory highlights an identifiability problem: a measured Poisson steady state is consistent with a large variety of microscopic models. Here, I provide a rigorous and intuitive explanation for the universality of the Poisson steady state. I show that the mRNA birth-death process and its complex decay variants all take the form of the familiar Poisson law of rare events, under a nonlinear rescaling of time. As a corollary, not only steady-states but also transients are Poisson distributed. Deviations from the Poisson form occur only under two conditions, promoter fluctuations leading to transcriptional bursts or nonindependent degradation of mRNA molecules. These results place severe limits on the power of single-cell experiments to probe microscopic mechanisms, and they highlight the need for single-molecule measurements. Copyright © 2016 The Authors. Published by Elsevier Inc. All rights reserved.

Coherence enhanced quantum metrology in a nonequilibrium optical molecule

NASA Astrophysics Data System (ADS)

Wang, Zhihai; Wu, Wei; Cui, Guodong; Wang, Jin

2018-03-01

We explore the quantum metrology in an optical molecular system coupled to two environments with different temperatures, using a quantum master equation beyond secular approximation. We discover that the steady-state coherence originating from and sustained by the nonequilibrium condition can enhance quantum metrology. We also study the quantitative measures of the nonequilibrium condition in terms of the curl flux, heat current and entropy production at the steady state. They are found to grow with temperature difference. However, an apparent paradox arises considering the contrary behaviors of the steady-state coherence and the nonequilibrium measures in relation to the inter-cavity coupling strength. This paradox is resolved by decomposing the heat current into a population part and a coherence part. Only the latter, the coherence part of the heat current, is tightly connected to the steady-state coherence and behaves similarly with respect to the inter-cavity coupling strength. Interestingly, the coherence part of the heat current flows from the low-temperature reservoir to the high-temperature reservoir, opposite to the direction of the population heat current. Our work offers a viable way to enhance quantum metrology for open quantum systems through steady-state coherence sustained by the nonequilibrium condition, which can be controlled and manipulated to maximize its utility. The potential applications go beyond quantum metrology and extend to areas such as device designing, quantum computation and quantum technology in general.

Proteome analysis of the Escherichia coli heat shock response under steady-state conditions

PubMed Central

Lüders, Svenja; Fallet, Claas; Franco-Lara, Ezequiel

2009-01-01

In this study a proteomic approach was used to investigate the steady-state response of Escherichia coli to temperature up-shifts in a cascade of two continuously operated bioreactors. The first reactor served as cell source with optimal settings for microbial growth, while in the second chemostat the cells were exposed to elevated temperatures. By using this reactor configuration, which has not been reported to be used for the study of bacterial stress responses so far, it is possible to study temperature stress under well-defined, steady-state conditions. Specifically the effect on the cellular adaption to temperature stress using two-dimensional gel electrophoresis was examined and compared at the cultivation temperatures of 37°C and 47.5°C. As expected, the steady-state study with the double bioreactor configuration delivered a different protein spectrum compared to that obtained with standard batch experiments in shaking flasks and bioreactors. Setting a high cut-out spot-to-spot size ratio of 5, proteins involved in defence against oxygen stress, functional cell envelope proteins, chaperones and proteins involved in protein biosynthesis, the energy metabolism and the amino acid biosynthesis were found to be differently expressed at high cultivation temperatures. The results demonstrate the complexity of the stress response in a steady-state culture not reported elsewhere to date. PMID:19772559

Evaluation of diffusion coefficients by means of an approximate steady-state condition in sedimentation velocity distributions.

PubMed

Scott, David J; Harding, Stephen E; Winzor, Donald J

2015-12-01

This investigation examined the feasibility of manipulating the rotor speed in sedimentation velocity experiments to spontaneously generate an approximate steady-state condition where the extent of diffusional spreading is matched exactly by the boundary sharpening arising from negative s-c dependence. Simulated sedimentation velocity distributions based on the sedimentation characteristics for a purified mucin preparation were used to illustrate a simple procedure for determining the diffusion coefficient from such steady-state distributions in situations where the concentration dependence of the sedimentation coefficient, s = s(0)/(1 + Kc), was quantified in terms of the limiting sedimentation coefficient as c → 0 (s(0)) and the concentration coefficient (K). Those simulations established that spontaneous generation of the approximate steady state could well be a feature of sedimentation velocity distributions for many unstructured polymer systems because the requirement that Kcoω(2)s(0)/D be between 46 and 183 cm(-2) is not unduly restrictive. Although spontaneous generation of the approximate steady state is also a theoretical prediction for structured macromolecular solutes exhibiting linear concentration dependence of the sedimentation coefficient, s = s(0)(1 - kc), the required value of k is far too large for any practical advantage to be taken of this approach with globular proteins. Copyright © 2015 Elsevier Inc. All rights reserved.

The number statistics and optimal history of non-equilibrium steady states of mortal diffusing particles

NASA Astrophysics Data System (ADS)

Meerson, Baruch

2015-05-01

Suppose that a point-like steady source at x = 0 injects particles into a half-infinite line. The particles diffuse and die. At long times a non-equilibrium steady state sets in, and we assume that it involves many particles. If the particles are non-interacting, their total number N in the steady state is Poisson-distributed with mean \\bar{N} predicted from a deterministic reaction-diffusion equation. Here we determine the most likely density history of this driven system conditional on observing a given N. We also consider two prototypical examples of interacting diffusing particles: (i) a family of mortal diffusive lattice gases with constant diffusivity (as illustrated by the simple symmetric exclusion process with mortal particles), and (ii) random walkers that can annihilate in pairs. In both examples we calculate the variances of the (non-Poissonian) stationary distributions of N.

Start Up of a Nb-1%Zr Potassium Heat Pipe From the Frozen State

NASA Technical Reports Server (NTRS)

Glass, David E.; Merrigan, Michael A.; Sena, J. Tom

1998-01-01

The start up of a liquid metal heat pipe from the frozen state was evaluated experimentally with a Nb-1%Zr heat pipe with potassium as the working fluid. The heat pipe was fabricated and tested at Los Alamos National Laboratory. RF induction heating was used to heat 13 cm of the 1-m-long heat pipe. The heat pipe and test conditions are well characterized so that the test data may be used for comparison with numerical analyses. An attempt was made during steady state tests to calibrate the heat input so that the heat input would be known during the transient cases. The heat pipe was heated to 675 C with a throughput of 600 W and an input heat flux of 6 W/cm(exp 2). Steady state tests, start up from the frozen state, and transient variations from steady state were performed.

Laboratory longitudinal diffusion tests: 1. Dimensionless formulations and validity of simplified solutions

NASA Astrophysics Data System (ADS)

Takeda, M.; Nakajima, H.; Zhang, M.; Hiratsuka, T.

2008-04-01

To obtain reliable diffusion parameters for diffusion testing, multiple experiments should not only be cross-checked but the internal consistency of each experiment should also be verified. In the through- and in-diffusion tests with solution reservoirs, test interpretation of different phases often makes use of simplified analytical solutions. This study explores the feasibility of steady, quasi-steady, equilibrium and transient-state analyses using simplified analytical solutions with respect to (i) valid conditions for each analytical solution, (ii) potential error, and (iii) experimental time. For increased generality, a series of numerical analyses are performed using unified dimensionless parameters and the results are all related to dimensionless reservoir volume (DRV) which includes only the sorptive parameter as an unknown. This means the above factors can be investigated on the basis of the sorption properties of the testing material and/or tracer. The main findings are that steady, quasi-steady and equilibrium-state analyses are applicable when the tracer is not highly sorptive. However, quasi-steady and equilibrium-state analyses become inefficient or impractical compared to steady state analysis when the tracer is non-sorbing and material porosity is significantly low. Systematic and comprehensive reformulation of analytical models enables the comparison of experimental times between different test methods. The applicability and potential error of each test interpretation can also be studied. These can be applied in designing, performing, and interpreting diffusion experiments by deducing DRV from the available information for the target material and tracer, combined with the results of this study.

Bounds on internal state variables in viscoplasticity

NASA Technical Reports Server (NTRS)

Freed, Alan D.

1993-01-01

A typical viscoplastic model will introduce up to three types of internal state variables in order to properly describe transient material behavior; they are as follows: the back stress, the yield stress, and the drag strength. Different models employ different combinations of these internal variables--their selection and description of evolution being largely dependent on application and material selection. Under steady-state conditions, the internal variables cease to evolve and therefore become related to the external variables (stress and temperature) through simple functional relationships. A physically motivated hypothesis is presented that links the kinetic equation of viscoplasticity with that of creep under steady-state conditions. From this hypothesis one determines how the internal variables relate to one another at steady state, but most importantly, one obtains bounds on the magnitudes of stress and back stress, and on the yield stress and drag strength.

ROLE OF NMDA, NICOTINIC, AND GABA RECEPTORS IN THE STEADY STATE VISUAL EVOKED POTENTIAL IN RATS.

EPA Science Inventory

This manuscript characterizes the receptor pathways involved in pattern-evoked potential generation in rats

" NMDA and nicotinic acetylcholine receptors appear to be involved in the generation of the steady-state pattern evoked response in vivo.

" The pattern evok...

Steady-State Multiplicity Features of Chemically Reacting Systems.

ERIC Educational Resources Information Center

Luss, Dan

1986-01-01

Analyzes steady-state multiplicity in chemical reactors, focusing on the use of two mathematical tools, namely, the catastrophe theory and the singularity theory with a distinguished parameter. These tools can be used to determine the maximum number of possible solutions and the different types of bifurcation diagrams. (JN)

How Cosmology Became a Science.

ERIC Educational Resources Information Center

Brush, Stephen G.

1992-01-01

Describes the origin of the science of cosmology and the competing theories to explain the beginning of the universe. The big bang theory for the creation of the universe is contrasted with the steady state theory. The author details discoveries that led to the demise of the steady state theory. (PR)

D-3He Spherical Torus Fusion Reactor System Study

DTIC Science & Technology

1992-04-01

assumed as a reasonable range. A.6 Steady-State Particle Balance The steady-state densities of the various species present in a burning plasma are...determined by a detailed particle balance calculation. In addition to the con- sumption and production of various species in a burning plasma , a

STEADY STATE FLAMMABLE GAS RELEASE RATE CALCULATION AND LOWER FLAMMABILITY LEVEL EVALUATION FOR HANFORD TANK WASTE

DOE Office of Scientific and Technical Information (OSTI.GOV)

HU TA

2009-10-26

Assess the steady-state flammability level at normal and off-normal ventilation conditions. The hydrogen generation rate was calculated for 177 tanks using the rate equation model. Flammability calculations based on hydrogen, ammonia, and methane were performed for 177 tanks for various scenarios.

Steady-State Pharmacokinetics of Bupropion SR in Juvenile Patients

ERIC Educational Resources Information Center

Daviss, W. Burleson; Perel, James M.; Rudolph, George R.; Axelson, David A.; Gilchrist, Richard; Nuss, Sharon; Birmaher, Boris; Brent, David A.

2005-01-01

Objective: To examine the steady-state pharmacokinetic properties of bupropion sustained release (SR) and their potential developmental differences in youths. Method: Eleven boys and eight girls aged 11 to 17 years old were prescribed bupropion SR monotherapy for attention-deficit/hyperactivity disorder (n = 16) and/or depressive disorders (n =…

User's instructions for the 41-node thermoregulatory model (steady state version)

NASA Technical Reports Server (NTRS)

Leonard, J. I.

1974-01-01

A user's guide for the steady-state thermoregulatory model is presented. The model was modified to provide conversational interaction on a remote terminal, greater flexibility for parameter estimation, increased efficiency of convergence, greater choice of output variable and more realistic equations for respiratory and skin diffusion water losses.

Steady-state inductive spheromak operation

DOEpatents

Janos, Alan C.; Jardin, Stephen C.; Yamada, Masaaki

1987-01-01

The inductively formed spheromak plasma can be maintained in a highly stable and controlled fashion. Steady-state operation is obtained by forming the plasma in the linked mode, then oscillating the poloidal and toroidal fields such that they have different phases. Preferably, the poloidal and magnetic fields are 90.degree. out of phase.

Steady fall of isothermal, resistive-viscous, compressible fluid across magnetic field

DOE Office of Scientific and Technical Information (OSTI.GOV)

Low, B. C., E-mail: low@ucar.edu; Egan, A. K., E-mail: andrea.egan@colorado.edu

This is a basic MHD study of the steady fall of an infinite, vertical slab of isothermal, resistive-viscous, compressible fluid across a dipped magnetic field in uniform gravity. This double-diffusion steady flow in unbounded space poses a nonlinear but numerically tractable, one-dimensional (1D) free-boundary problem, assuming constant coefficients of resistivity and viscosity. The steady flow is determined by a dimensionless number μ{sub 1} proportional to the triple product of the two diffusion coefficients and the square of the linear total mass. For a sufficiently large μ{sub 1}, the Lorentz, viscous, fluid-pressure, and gravitational forces pack and collimate the fluid intomore » a steady flow of a finite width defined by the two zero-pressure free-boundaries of the slab with vacuum. The viscous force is essential in this collimation effect. The study conjectures that in the regime μ{sub 1}→0, the 1D steady state exists only for μ{sub 1}∈Ω, a spectrum of an infinite number of discrete values, including μ{sub 1} = 0 that corresponds to two steady states, the classical zero-resistivity static slab of Kippenhahn and Schlüter [R. Kippenhahn and A. Schlüter, Z. Astrophys. 43, 36 (1957)] and its recent generalization [B. C. Low et al., Astrophys. J. 755, 34 (2012)] to admit an inviscid resistive flow. The pair of zero-pressure boundaries of each of the μ{sub 1}→0 steady-state slabs are located at infinity. Computational evidence suggests that the Ω steady-states are densely distributed around μ{sub 1} = 0, as an accumulation point, but are sparsely separated by open intervals of μ{sub 1}-values for which the slab must be either time-dependent or spatially multi-dimensional. The widths of these intervals are vanishingly small as μ{sub 1}→0. This topological structure of physical states is similar to that described by Landau and Liftshitz [L. D. Landau and E. M. Lifshitz, Fluid Mechanics (Addison-Wesley, Reading, MA, 1959)] to explain the onset of hydrodynamic turbulence. The implications of this MHD study are discussed, with an interest in the prominences in the solar atmosphere and the interstellar clouds in the Galaxy.« less

A surface renewal model for unsteady-state mass transfer using the generalized Danckwerts age distribution function

PubMed Central

Horvath, Isabelle R.

2018-01-01

The recently derived steady-state generalized Danckwerts age distribution is extended to unsteady-state conditions. For three different wind speeds used by researchers on air–water heat exchange on the Heidelberg Aeolotron, calculations reveal that the distribution has a sharp peak during the initial moments, but flattens out and acquires a bell-shaped character with process time, with the time taken to attain a steady-state profile being a strong and inverse function of wind speed. With increasing wind speed, the age distribution narrows significantly, its skewness decreases and its peak becomes larger. The mean eddy renewal time increases linearly with process time initially but approaches a final steady-state value asymptotically, which decreases dramatically with increased wind speed. Using the distribution to analyse the transient absorption of a gas into a large body of liquid, assuming negligible gas-side mass-transfer resistance, estimates are made of the gas-absorption and dissolved-gas transfer coefficients for oxygen absorption in water at 25°C for the three different wind speeds. Under unsteady-state conditions, these two coefficients show an inverse behaviour, indicating a heightened accumulation of dissolved gas in the surface elements, especially during the initial moments of absorption. However, the two mass-transfer coefficients start merging together as the steady state is approached. Theoretical predictions of the steady-state mass-transfer coefficient or transfer velocity are in fair agreement (average absolute error of prediction = 18.1%) with some experimental measurements of the same for the nitrous oxide–water system at 20°C that were made in the Heidelberg Aeolotron. PMID:29892429

Transient competitive complexation in biological kinetic isotope fractionation explains non-steady isotopic effects: Theory and application to denitrification in soils

DOE Office of Scientific and Technical Information (OSTI.GOV)

Maggi, F.M.; Riley, W.J.

2009-06-01

The theoretical formulation of biological kinetic reactions in isotopic applications often assume first-order or Michaelis-Menten-Monod kinetics under the quasi-steady-state assumption to simplify the system kinetics. However, isotopic e ects have the same order of magnitude as the potential error introduced by these simpli cations. Both formulations lead to a constant fractionation factor which may yield incorrect estimations of the isotopic effect and a misleading interpretation of the isotopic signature of a reaction. We have analyzed the isotopic signature of denitri cation in biogeochemical soil systems by Menyailo and Hungate [2006], where high {sup 15}N{sub 2}O enrichment during N{sub 2}O productionmore » and inverse isotope fractionation during N{sub 2}O consumption could not be explained with first-order kinetics and the Rayleigh equation, or with the quasi-steady-state Michaelis-Menten-Monod kinetics. When the quasi-steady-state assumption was relaxed, transient Michaelis-Menten-Monod kinetics accurately reproduced the observations and aided in interpretation of experimental isotopic signatures. These results may imply a substantial revision in using the Rayleigh equation for interpretation of isotopic signatures and in modeling biological kinetic isotope fractionation with first-order kinetics or quasi-steady-state Michaelis-Menten-Monod kinetics.« less

A series RCL circuit theory for analyzing non-steady-state water uptake of maize plants.

PubMed

Zhuang, Jie; Yu, Gui-Rui; Nakayama, Keiichi

2014-10-22

Understanding water uptake and transport through the soil-plant continuum is vital for ecosystem management and agricultural water use. Plant water uptake under natural conditions is a non-steady transient flow controlled by root distribution, plant configuration, soil hydraulics, and climatic conditions. Despite significant progress in model development, a mechanistic description of transient water uptake has not been developed or remains incomplete. Here, based on advanced electrical network theory (RLC circuit theory), we developed a non-steady state biophysical model to mechanistically analyze the fluctuations of uptake rates in response to water stress. We found that the non-steady-state model captures the nature of instantaneity and hysteresis of plant water uptake due to the considerations of water storage in plant xylem and coarse roots (capacitance effect), hydraulic architecture of leaf system (inductance effect), and soil-root contact (fuse effect). The model provides insights into the important role of plant configuration and hydraulic heterogeneity in helping plants survive an adverse environment. Our tests against field data suggest that the non-steady-state model has great potential for being used to interpret the smart water strategy of plants, which is intrinsically determined by stem size, leaf size/thickness and distribution, root system architecture, and the ratio of fine-to-coarse root lengths.

A Ratio-Analysis Method to the Dynamics of Excited State Proton Transfer: Pyranine in Water and Micelles.

PubMed

Sahu, Kalyanasis; Nandi, Nilanjana; Dolai, Suman; Bera, Avisek

2018-06-05

Emission spectrum of a fluorophore undergoing excited state proton transfer (ESPT) often exhibits two distinct bands each representing emissions from protonated and deprotonated forms. The relative contribution of the two bands, best represented by an emission intensity ratio (R) (intensity maximum of the protonated band / intensity maximum of the deprotonated band), is an important parameter which usually denotes feasibility or promptness of the ESPT process. However, the use of ratio is only limited to the interpretation of steady-state fluorescence spectra. Here, for the first time, we exploit the time-dependence of the ratio (R(t)), calculated from time-resolved emission spectra (TRES) at different times, to analyze ESPT dynamics. TRES at different times were fitted with a sum of two lognormal-functions representing each peaks and then, the peak intensity ratio, R(t) was calculated and further fitted with an analytical function. Recently, a time-resolved area-normalized emission spectra (TRANES)-based analysis was presented where the decay of protonated emission or the rise of deprotonated emission intensity conveniently accounts for the ESPT dynamics. We show that these two methods are equivalent but the new method provides more insights on the nature of the ESPT process.

How should we understand non-equilibrium many-body steady states?

NASA Astrophysics Data System (ADS)

Maghrebi, Mohammad; Gorshkov, Alexey

: Many-body systems with both coherent dynamics and dissipation constitute a rich class of models which are nevertheless much less explored than their dissipationless counterparts. The advent of numerous experimental platforms that simulate such dynamics poses an immediate challenge to systematically understand and classify these models. In particular, nontrivial many-body states emerge as steady states under non-equilibrium dynamics. In this talk, I use a field-theoretic approach based on the Keldysh formalism to study nonequilibrium phases and phase transitions in such models. I show that an effective temperature generically emerges as a result of dissipation, and the universal behavior including the dynamics near the steady state is described by a thermodynamic universality class. In the end, I will also discuss possibilities that go beyond the paradigm of an effective thermodynamic behavior.

Steady state whistler turbulence and stability of thermal barriers in tandem mirrors

DOE Office of Scientific and Technical Information (OSTI.GOV)

Litwin, C.; Sudan, R.N.

The effect of the whistler turbulence on anisotropic electrons in a thermal barrier is examined. The electron distribution function is derived self-consistently by solving the steady state quasilinear diffusion equation. Saturated amplitudes are computed using the resonance broadening theory or convective stabilization. Estimated power levels necessary for sustaining the steady state of a strongly anisotropic electron population are found to exceed by orders of magnitude the estimates based on Fokker--Planck calculations for the range of parameters of tandem mirror (TMX-U and MFTF-B) experiments (Nucl. Fusion 25, 1205 (1985)). Upper limits on the allowed degree of anisotropy for existing power densitiesmore » are calculated.« less

Comparing Interval Management Control Laws for Steady-State Errors and String Stability

NASA Technical Reports Server (NTRS)

Weitz, Lesley A.; Swieringa, Kurt A.

2018-01-01

Interval Management (IM) is a future airborne spacing concept that leverages avionics to provide speed guidance to an aircraft to achieve and maintain a specified spacing interval from another aircraft. The design of a speed control law to achieve the spacing goal is a key aspect in the research and development of the IM concept. In this paper, two control laws that are used in much of the contemporary IM research are analyzed and compared to characterize steady-state errors and string stability. Numerical results are used to illustrate how the choice of control laws gains impacts the size of steady-state errors and string performance and the potential trade-offs between those performance characteristics.

Characterization of the space shuttle reaction control system engine

NASA Technical Reports Server (NTRS)

Wilson, M. S.; Stechman, R. C.; Edelman, R. B.; Fortune, O. F.; Economos, C.

1972-01-01

A computer program was developed and written in FORTRAN 5 which predicts the transient and steady state performance and heat transfer characteristics of a pulsing GO2/GH2 rocket engine. This program predicts the dynamic flow and ignition characteristics which, when combined in a quasi-steady state manner with the combustion and mixing analysis program, will provide the thrust and specific impulse of the engine as a function of time. The program also predicts the transient and steady state heat transfer characteristics of the engine using various cooling concepts. The computer program, test case, and documentation are presented. The program is applicable to any system capable of utilizing the FORTRAN 4 or FORTRAN 5 language.

A far-field non-reflecting boundary condition for two-dimensional wake flows

NASA Technical Reports Server (NTRS)

Danowitz, Jeffrey S.; Abarbanel, Saul A.; Turkel, Eli

1995-01-01

Far-field boundary conditions for external flow problems have been developed based upon long-wave perturbations of linearized flow equations about a steady state far field solution. The boundary improves convergence to steady state in single-grid temporal integration schemes using both regular-time-stepping and local-time-stepping. The far-field boundary may be near the trailing edge of the body which significantly reduces the number of grid points, and therefore the computational time, in the numerical calculation. In addition the solution produced is smoother in the far-field than when using extrapolation conditions. The boundary condition maintains the convergence rate to steady state in schemes utilizing multigrid acceleration.

An improved VSS NLMS algorithm for active noise cancellation

NASA Astrophysics Data System (ADS)

Sun, Yunzhuo; Wang, Mingjiang; Han, Yufei; Zhang, Congyan

2017-08-01

In this paper, an improved variable step size NLMS algorithm is proposed. NLMS has fast convergence rate and low steady state error compared to other traditional adaptive filtering algorithm. But there is a contradiction between the convergence speed and steady state error that affect the performance of the NLMS algorithm. Now, we propose a new variable step size NLMS algorithm. It dynamically changes the step size according to current error and iteration times. The proposed algorithm has simple formulation and easily setting parameters, and effectively solves the contradiction in NLMS. The simulation results show that the proposed algorithm has a good tracking ability, fast convergence rate and low steady state error simultaneously.

Transport of a decay chain in homogenous porous media: analytical solutions.

PubMed

Bauer, P; Attinger, S; Kinzelbach, W

2001-06-01

With the aid of integral transforms, analytical solutions for the transport of a decay chain in homogenous porous media are derived. Unidirectional steady-state flow and radial steady-state flow in single and multiple porosity media are considered. At least in Laplace domain, all solutions can be written in closed analytical formulae. Partly, the solutions can also be inverted analytically. If not, analytical calculation of the steady-state concentration distributions, evaluation of temporal moments and numerical inversion are still possible. Formulae for several simple boundary conditions are given and visualized in this paper. The derived novel solutions are widely applicable and are very useful for the validation of numerical transport codes.

Steady-state LPO is not always reached in high-strain shear zones

NASA Astrophysics Data System (ADS)

Kumamoto, K. M.; Warren, J. M.

2017-12-01

Seismic anisotropy in the upper mantle results from the alignment of olivine crystal lattices during flow by dislocation creep. Experiments on the evolution of olivine lattice preferred orientation (LPO) as a function of shear strain have found that high strains (>10) are necessary to achieve a steady-state LPO (i.e., the dominant slip system does not change appreciably with further strain) when a pre-existing LPO is present. At lower strain ( 2), a pseudo-steady-state fabric is reached, in which the [100] axes of olivine reach a steady orientation relative to the deformation kinematics, but the [010] and [001] axes continue to evolve (e.g. Hansen et al., 2014). To constrain LPO evolution at mantle conditions, we looked at the LPO variation across three high temperature mantle shear zones in the Josephine Peridotite of SW Oregon. These shear zones provide a rare opportunity to examine LPO evolution in natural samples as a function of shear strain, due to the presence of a pyroxene foliation that serves as a strain marker. Observations of two of these shear zones are consistent with experimental observations (Warren et al., 2008; Skemer et al., 2010). Shear Zone G reaches a steady-state LPO at a strain of >20. Shear Zone P reaches a pseudo-steady-state LPO, with a consistent [100] axis orientation, at a strain of 3.5. However, a steady-state orientation is not reached in the [010] or [001] axes at the maximum strain of 5.25. The third shear zone, Shear Zone A, does not appear to reach even a pseudo-steady-state LPO, despite reaching strains >20 at its center. Instead, the dominant slip plane switches back and forth between the (010) and (001) planes with increasing strain, while the [100] axis orientations continue to evolve. Unusually, at peak strain, the [100] axes are oriented 40° past the shear plane. In contrast, the other two shear zones, along with other natural and experimental examples, have the [100] axes oriented approximately parallel to the shear direction at very high strain. The high angle of the [100] axes to the shear direction at high strain in SZA may explain angular offsets between plate motion and fast seismic direction, for instance as seen in the MELT experiment (Wolfe and Solomon, 1998). Hansen et al., 2014, EPSLSkemer et al., 2010, J. Pet. Warren et al., 2008, EPSLWolfe and Solomon, 1998, Science

Stochastic pumping of non-equilibrium steady-states: how molecules adapt to a fluctuating environment.

PubMed

Astumian, R D

2018-01-11

In the absence of input energy, a chemical reaction in a closed system ineluctably relaxes toward an equilibrium state governed by a Boltzmann distribution. The addition of a catalyst to the system provides a way for more rapid equilibration toward this distribution, but the catalyst can never, in and of itself, drive the system away from equilibrium. In the presence of external fluctuations, however, a macromolecular catalyst (e.g., an enzyme) can absorb energy and drive the formation of a steady state between reactant and product that is not determined solely by their relative energies. Due to the ubiquity of non-equilibrium steady states in living systems, the development of a theory for the effects of external fluctuations on chemical systems has been a longstanding focus of non-equilibrium thermodynamics. The theory of stochastic pumping has provided insight into how a non-equilibrium steady-state can be formed and maintained in the presence of dissipation and kinetic asymmetry. This effort has been greatly enhanced by a confluence of experimental and theoretical work on synthetic molecular machines designed explicitly to harness external energy to drive non-equilibrium transport and self-assembly.

Application of quasi-steady state methods to molecular motor transport on microtubules in fungal hyphae.

PubMed

Dauvergne, Duncan; Edelstein-Keshet, Leah

2015-08-21

We consider bidirectional transport of cargo by molecular motors dynein and kinesin that walk along microtubules, and/or diffuse in the cell. The motors compete to transport cargo in opposite directions with respect to microtubule polarity (towards the plus or minus end of the microtubule). In recent work, Gou et al. (2014) used a hierarchical set of models, each consisting of continuum transport equations to track the evolution of motors and their cargo (early endosomes) in the specific case of the fungus Ustilago maydis. We complement their work using a framework of quasi-steady state analysis developed by Newby and Bressloff (2010) and Bressloff and Newby (2013) to reduce the models to an approximating steady state Fokker-Plank equation. This analysis allows us to find analytic approximations to the steady state solutions in many cases where the full models are not easily solved. Consequently, we can make predictions about parameter dependence of the resulting spatial distributions. We also characterize the overall rates of bulk transport and diffusion, and how these are related to state transition parameters, motor speeds, microtubule polarity distribution, and specific assumptions made. Copyright © 2015 Elsevier Ltd. All rights reserved.

The fluorescence intensities ratio is not a reliable parameter for evaluation of protein unfolding transitions.

PubMed

Žoldák, Gabriel; Jancura, Daniel; Sedlák, Erik

2017-06-01

Monitoring the fluorescence of proteins, particularly the fluorescence of intrinsic tryptophan residues, is a popular method often used in the analysis of unfolding transitions (induced by temperature, chemical denaturant, and pH) in proteins. The tryptophan fluorescence provides several suitable parameters, such as steady-state fluorescence intensity, apparent quantum yield, mean fluorescence lifetime, position of emission maximum that are often utilized for the observation of the conformational/unfolding transitions of proteins. In addition, the fluorescence intensities ratio at different wavelengths (usually at 330 nm and 350 nm) is becoming an increasingly popular parameter for the evaluation of thermal transitions. We show that, under certain conditions, the use of this parameter for the analysis of unfolding transitions leads to the incorrect determination of thermodynamic parameters characterizing unfolding transitions in proteins (e.g., melting temperature) and, hence, can compromise the hit identification during high-throughput drug screening campaigns. © 2017 The Protein Society.

Nonfixed Retirement Age for University Professors: Modeling Its Effects on New Faculty Hires.

PubMed

Larson, Richard C; Diaz, Mauricio Gomez

2012-03-01

We model the set of tenure-track faculty members at a university as a queue, where "customers" in queue are faculty members in active careers. Arrivals to the queue are usually young, untenured assistant professors, and departures from the queue are primarily those who do not pass a promotion or tenure hurdle and those who retire. There are other less-often-used ways to enter and leave the queue. Our focus is on system effects of the elimination of mandatory retirement age. In particular, we are concerned with estimating the number of assistant professor slots that annually are no longer available because of the elimination of mandatory retirement. We start with steady-state assumptions that require use of Little's Law of Queueing, and we progress to a transient model using system dynamics. We apply these simple models using available data from our home university, the Massachusetts Institute of Technology.

Nonfixed Retirement Age for University Professors: Modeling Its Effects on New Faculty Hires

PubMed Central

Larson, Richard C.; Diaz, Mauricio Gomez

2013-01-01

We model the set of tenure-track faculty members at a university as a queue, where “customers” in queue are faculty members in active careers. Arrivals to the queue are usually young, untenured assistant professors, and departures from the queue are primarily those who do not pass a promotion or tenure hurdle and those who retire. There are other less-often-used ways to enter and leave the queue. Our focus is on system effects of the elimination of mandatory retirement age. In particular, we are concerned with estimating the number of assistant professor slots that annually are no longer available because of the elimination of mandatory retirement. We start with steady-state assumptions that require use of Little’s Law of Queueing, and we progress to a transient model using system dynamics. We apply these simple models using available data from our home university, the Massachusetts Institute of Technology. PMID:23936582

Production and Purification of Recombinant SUMOylated Proteins Using Engineered Bacteria.

PubMed

Brockly, Frédérique; Piechaczyk, Marc; Bossis, Guillaume

2016-01-01

SUMO is a ubiquitin-like protein that is covalently conjugated to numerous cellular proteins to modify their function and fate. Although large progresses have been made in the identification of SUMOylated proteins, the molecular consequences of their SUMOylation are generally unknown. This is, most often, due to the low abundance of SUMOylated proteins in the cell, usually less than 1 % of a given protein being modified at steady state. To gain insights into the role of specific SUMOylation targets, SUMO conjugation can be reconstituted in vitro using purified proteins. However, for most substrates, the efficiency of in vitro SUMOylation is too low to obtain sufficient amounts of their SUMOylated forms for biochemical studies. Here, we describe a detailed protocol to purify large amounts of recombinant SUMOylated proteins using bacteria modified to express His-tagged SUMO as well as the SUMO-activating and -conjugating enzymes.

Intermittency, nonlinear dynamics and dissipation in the solar wind and astrophysical plasmas

PubMed Central

Matthaeus, W. H.; Wan, Minping; Servidio, S.; Greco, A.; Osman, K. T.; Oughton, S.; Dmitruk, P.

2015-01-01

An overview is given of important properties of spatial and temporal intermittency, including evidence of its appearance in fluids, magnetofluids and plasmas, and its implications for understanding of heliospheric plasmas. Spatial intermittency is generally associated with formation of sharp gradients and coherent structures. The basic physics of structure generation is ideal, but when dissipation is present it is usually concentrated in regions of strong gradients. This essential feature of spatial intermittency in fluids has been shown recently to carry over to the realm of kinetic plasma, where the dissipation function is not known from first principles. Spatial structures produced in intermittent plasma influence dissipation, heating, and transport and acceleration of charged particles. Temporal intermittency can give rise to very long time correlations or a delayed approach to steady-state conditions, and has been associated with inverse cascade or quasi-inverse cascade systems, with possible implications for heliospheric prediction. PMID:25848085

Non-standard models and the sociology of cosmology

NASA Astrophysics Data System (ADS)

López-Corredoira, Martín

2014-05-01

I review some theoretical ideas in cosmology different from the standard "Big Bang": the quasi-steady state model, the plasma cosmology model, non-cosmological redshifts, alternatives to non-baryonic dark matter and/or dark energy, and others. Cosmologists do not usually work within the framework of alternative cosmologies because they feel that these are not at present as competitive as the standard model. Certainly, they are not so developed, and they are not so developed because cosmologists do not work on them. It is a vicious circle. The fact that most cosmologists do not pay them any attention and only dedicate their research time to the standard model is to a great extent due to a sociological phenomenon (the "snowball effect" or "groupthink"). We might well wonder whether cosmology, our knowledge of the Universe as a whole, is a science like other fields of physics or a predominant ideology.

Non-canonical distribution and non-equilibrium transport beyond weak system-bath coupling regime: A polaron transformation approach

NASA Astrophysics Data System (ADS)

Xu, Dazhi; Cao, Jianshu

2016-08-01

The concept of polaron, emerged from condense matter physics, describes the dynamical interaction of moving particle with its surrounding bosonic modes. This concept has been developed into a useful method to treat open quantum systems with a complete range of system-bath coupling strength. Especially, the polaron transformation approach shows its validity in the intermediate coupling regime, in which the Redfield equation or Fermi's golden rule will fail. In the polaron frame, the equilibrium distribution carried out by perturbative expansion presents a deviation from the canonical distribution, which is beyond the usual weak coupling assumption in thermodynamics. A polaron transformed Redfield equation (PTRE) not only reproduces the dissipative quantum dynamics but also provides an accurate and efficient way to calculate the non-equilibrium steady states. Applications of the PTRE approach to problems such as exciton diffusion, heat transport and light-harvesting energy transfer are presented.

The radial electric field dynamics in the neoclassical plasmas

DOE Office of Scientific and Technical Information (OSTI.GOV)

Novakovskii, S.V.; Liu, C.S.; Sagdeev, R.Z.

1997-12-01

A numerical simulation and analytical theory of the radial electric field dynamics in low collisional tokamak plasmas are presented. An initial value code {open_quotes}ELECTRIC{close_quotes} has been developed to solve the ion drift kinetic equation with a full collisional operator in the Hirshman{endash}Sigmar{endash}Clarke form together with the Maxwell equations. Different scenarios of relaxation of the radial electric field toward the steady-state in response to sudden and adiabatic changes of the equilibrium temperature gradient are presented. It is shown, that while the relaxation is usually accompanied by the geodesic acoustic oscillations, during the adiabatic change these oscillations are suppressed and only themore » magnetic pumping remains. Both the collisional damping and the Landau resonance interaction are shown to be important relaxation mechanisms. Scalings of the relaxation rates versus basic plasma parameters are presented. {copyright} {ital 1997 American Institute of Physics.}« less

Application of cosmic-ray shock theories to the Cygnus Loop - An alternative model

NASA Technical Reports Server (NTRS)

Boulares, Ahmed; Cox, Donald P.

1988-01-01

Steady state cosmic-ray shock models are investigated here in the light of observations of the Cygnus Loop supernova remnant. The predicted downstream temperature is derived for each model. The Cygnus Loop data and the application of the models to them, including wave dissipation, are presented. Heating rate and ionization fraction structures are provided along with an estimate of the cosmic-ray diffusion coefficient. It is found that the model of Voelk, Drury, and McKenzie (1984), in which the plasma waves are generated by the streaming instability of the cosmic rays and are dissipated into the gas, can be made consistent with some observed characteristics of the Cygnus Loop shocks. The model is used to deduce upstream densities and shock velocities and, compared to the usual pure gas shock interpretation, it is found that lower densities and approximately three times higher velocities are required.

A Steady State Visually Evoked Potential Investigation of Memory and Ageing

ERIC Educational Resources Information Center

Macpherson, Helen; Pipingas, Andrew; Silberstein, Richard

2009-01-01

Old age is generally accompanied by a decline in memory performance. Specifically, neuroimaging and electrophysiological studies have revealed that there are age-related changes in the neural correlates of episodic and working memory. This study investigated age-associated changes in the steady state visually evoked potential (SSVEP) amplitude and…

Performance Assessment of Hearing Protection and Communication Enhancement Devices: Peltor Comtac III and IV

DTIC Science & Technology

2015-07-01

providing a hear-thru, or active capability while mitigating hearing loss and tinnitus caused by exposure to loud, steady-state and impulse noise. Active...loss and tinnitus caused by exposure to loud, steady-state and impulse noise. The general approach was to use ANSI standard measurement procedures

Steady States of the Parametric Rotator and Pendulum

ERIC Educational Resources Information Center

Bouzas, Antonio O.

2010-01-01

We discuss several steady-state rotation and oscillation modes of the planar parametric rotator and pendulum with damping. We consider a general elliptic trajectory of the suspension point for both rotator and pendulum, for the latter at an arbitrary angle with gravity, with linear and circular trajectories as particular cases. We treat the…

Stream network and stream segment temperature models software

USGS Publications Warehouse

Bartholow, John

2010-01-01

This set of programs simulates steady-state stream temperatures throughout a dendritic stream network handling multiple time periods per year. The software requires a math co-processor and 384K RAM. Also included is a program (SSTEMP) designed to predict the steady state stream temperature within a single stream segment for a single time period.

The Cost Structure of Higher Education: Implications for Governmental Policy in Steady State.

ERIC Educational Resources Information Center

Lyell, Edward H.

The historical pattern of resource allocation in American higher education as exemplified by public colleges in Colorado was examined. The reliance upon average cost information in making resource allocation decisions was critiqued for the special problems that arise from student enrollment decline or steady state. A model of resource allocation…

46 CFR 160.174-3 - Incorporation by reference.

Code of Federal Regulations, 2010 CFR

2010-10-01

... by reference in this subpart are: American Society for Testing and Materials (ASTM) 100 Barr Harbor Drive, West Conshohocken, PA 19428-2959. ASTM C 177-85 (1993), Standard Test Method for Steady-State...—160.174-17 ASTM C 518-91, Standard Test Method for Steady-State Heat Flux Measurements and Thermal...

Steady-State Squeezing in the Micromaser Cavity Field

NASA Technical Reports Server (NTRS)

Nayak, N.

1996-01-01

It is shown that the radiation field in the presently operated micromaser cavity may be squeezed when pumped with polarized atoms. The squeezing is in the steady state field corresponding to the action similar to that of the conventional micromaser, with the effect of cavity dissipation during entire t(sub c) = tau + t(sub cav).

Numerical Modeling of One-Dimensional Steady-State Flow and Contaminant Transport in a Horizontally Heterogeneous Unconfined Aquifer with an Uneven Base

EPA Science Inventory

Algorithms and a short description of the D1_Flow program for numerical modeling of one-dimensional steady-state flow in horizontally heterogeneous aquifers with uneven sloping bases are presented. The algorithms are based on the Dupuit-Forchheimer approximations. The program per...

Dynamic variation in sapwood specific conductivity in six woody species.

Treesearch

J.C. Domec; F.C. Meinzer; B.L. Gartner; J. Housset

2007-01-01

Relationships between pressure gradients and flow rates in the xylem are incompletely understood because steady-state conductivity coefficients are inadequate for predicting and interpreting flow under the non-steady-state conditions more prevalent in intact trees. The goal of this study was to determine the magnitude of deviation of trunk sapwood specific conductivity...

Introducing Michaelis-Menten Kinetics through Simulation

ERIC Educational Resources Information Center

Halkides, Christopher J.; Herman, Russell

2007-01-01

We describe a computer tutorial that introduces the concept of the steady state in enzyme kinetics. The tutorial allows students to produce graphs of the concentrations of free enzyme, enzyme-substrate complex, and product versus time in order to learn about the approach to steady state. By using a range of substrate concentrations and rate…

Steady-State Staffing: A Second Report.

ERIC Educational Resources Information Center

Furniss, W. Todd

This is a folow-up report on developments in long-range faculty personnel planning since the publication of "Steady-State Staffing in Tenure-Granting Institutions and Related Papers," covering the period from March through December 1973. Following references to newly available data, the paper deals first with work done at SUNY-Buffalo, Stanford,…

40 CFR 1051.505 - What special provisions apply for testing snowmobiles?

Code of Federal Regulations, 2010 CFR

2010-07-01

... provisions for testing snowmobiles: (a) You may perform steady-state testing with either discrete-mode or... both discrete-mode and ramped-modal testing (either in your original application or in an amendment to... as allowed by the Clean Air Act. Measure steady-state emissions as follows: (1) For discrete-mode...

Analytical steady-state solutions for water-limited cropping systems using saline irrigation water

USDA-ARS?s Scientific Manuscript database

Due to the diminishing availability of good quality water for irrigation, it is increasingly important that irrigation and salinity management tools be able to target submaximal crop yields and support the use of marginal quality waters. In this work, we present a steady-state irrigated systems mod...

78 FR 65206 - Airworthiness Directives; Bell Helicopter Textron Canada Limited (Bell) Helicopters

Federal Register 2010, 2011, 2012, 2013, 2014

2013-10-31

... engine speeds during steady- state operations. These actions are intended to alert pilots to avoid... intended to alert pilots to avoid certain engine speeds during steady- state operations, prevent failure of... decal as described in Bell Alert Service Bulletin (ASB) No. 430-05-34, dated June 10, 2005 (ASB 430-05...

78 FR 65200 - Airworthiness Directives; Bell Helicopter Textron Canada Limited (Bell) Helicopters

Federal Register 2010, 2011, 2012, 2013, 2014

2013-10-31

... vibrations at certain engine speeds during steady- state operations. These actions are intended to alert... proposed requirements were intended to alert pilots to avoid certain engine speeds during steady-state... the change, and installing a decal as described in Bell Alert Service Bulletin (ASB) No. 407-05-67...

40 CFR 86.1362-2007 - Steady-state testing with a ramped-modal cycle.

Code of Federal Regulations, 2010 CFR

2010-07-01

...-modal cycle. 86.1362-2007 Section 86.1362-2007 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY... (CONTINUED) Emission Regulations for New Otto-Cycle and Diesel Heavy-Duty Engines; Gaseous and Particulate Exhaust Test Procedures § 86.1362-2007 Steady-state testing with a ramped-modal cycle. This section...

40 CFR 86.1362-2010 - Steady-state testing with a ramped-modal cycle.

Code of Federal Regulations, 2010 CFR

2010-07-01

...-modal cycle. 86.1362-2010 Section 86.1362-2010 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY... (CONTINUED) Emission Regulations for New Otto-Cycle and Diesel Heavy-Duty Engines; Gaseous and Particulate Exhaust Test Procedures § 86.1362-2010 Steady-state testing with a ramped-modal cycle. This section...

A novel milliliter-scale chemostat system for parallel cultivation of microorganisms in stirred-tank bioreactors.

PubMed

Schmideder, Andreas; Severin, Timm Steffen; Cremer, Johannes Heinrich; Weuster-Botz, Dirk

2015-09-20

A pH-controlled parallel stirred-tank bioreactor system was modified for parallel continuous cultivation on a 10 mL-scale by connecting multichannel peristaltic pumps for feeding and medium removal with micro-pipes (250 μm inner diameter). Parallel chemostat processes with Escherichia coli as an example showed high reproducibility with regard to culture volume and flow rates as well as dry cell weight, dissolved oxygen concentration and pH control at steady states (n=8, coefficient of variation <5%). Reliable estimation of kinetic growth parameters of E. coli was easily achieved within one parallel experiment by preselecting ten different steady states. Scalability of milliliter-scale steady state results was demonstrated by chemostat studies with a stirred-tank bioreactor on a liter-scale. Thus, parallel and continuously operated stirred-tank bioreactors on a milliliter-scale facilitate timesaving and cost reducing steady state studies with microorganisms. The applied continuous bioreactor system overcomes the drawbacks of existing miniaturized bioreactors, like poor mass transfer and insufficient process control. Copyright © 2015 Elsevier B.V. All rights reserved.

Onsager's variational principle for the dynamics of a vesicle in a Poiseuille flow

NASA Astrophysics Data System (ADS)

Oya, Yutaka; Kawakatsu, Toshihiro

2018-03-01

We propose a systematic formulation of the migration behaviors of a vesicle in a Poiseuille flow based on Onsager's variational principle, which can be used to determine the most stable steady state. Our model is described by a combination of the phase field theory for the vesicle and the hydrodynamics for the flow field. The dynamics is governed by the bending elastic energy and the dissipation functional, the latter being composed of viscous dissipation of the flow field, dissipation of the bending energy of the vesicle, and the friction between the vesicle and the flow field. We performed a series of simulations on 2-dimensional systems by changing the bending elasticity of the membrane and observed 3 types of steady states, i.e., those with slipper shape, bullet shape, and snaking motion, and a quasi-steady state with zig-zag motion. We show that the transitions among these steady states can be quantitatively explained by evaluating the dissipation functional, which is determined by the competition between the friction on the vesicle surface and the viscous dissipation in the bulk flow.

An evaluation of random analysis methods for the determination of panel damping

NASA Technical Reports Server (NTRS)

Bhat, W. V.; Wilby, J. F.

1972-01-01

An analysis is made of steady-state and non-steady-state methods for the measurement of panel damping. Particular emphasis is placed on the use of random process techniques in conjunction with digital data reduction methods. The steady-state methods considered use the response power spectral density, response autocorrelation, excitation-response crosspower spectral density, or single-sided Fourier transform (SSFT) of the response autocorrelation function. Non-steady-state methods are associated mainly with the use of rapid frequency sweep excitation. Problems associated with the practical application of each method are evaluated with specific reference to the case of a panel exposed to a turbulent airflow, and two methods, the power spectral density and the single-sided Fourier transform methods, are selected as being the most suitable. These two methods are demonstrated experimentally, and it is shown that the power spectral density method is satisfactory under most conditions, provided that appropriate corrections are applied to account for filter bandwidth and background noise errors. Thus, the response power spectral density method is recommended for the measurement of the damping of panels exposed to a moving airflow.

Computational Study of Axisymmetric Off-Design Nozzle Flows

NASA Technical Reports Server (NTRS)

DalBello, Teryn; Georgiadis, Nicholas; Yoder, Dennis; Keith, Theo

2003-01-01

Computational Fluid Dynamics (CFD) analyses of axisymmetric circular-arc boattail nozzles operating off-design at transonic Mach numbers have been completed. These computations span the very difficult transonic flight regime with shock-induced separations and strong adverse pressure gradients. External afterbody and internal nozzle pressure distributions computed with the Wind code are compared with experimental data. A range of turbulence models were examined, including the Explicit Algebraic Stress model. Computations have been completed at freestream Mach numbers of 0.9 and 1.2, and nozzle pressure ratios (NPR) of 4 and 6. Calculations completed with variable time-stepping (steady-state) did not converge to a true steady-state solution. Calculations obtained using constant timestepping (timeaccurate) indicate less variations in flow properties compared with steady-state solutions. This failure to converge to a steady-state solution was the result of using variable time-stepping with large-scale separations present in the flow. Nevertheless, time-averaged boattail surface pressure coefficient and internal nozzle pressures show reasonable agreement with experimental data. The SST turbulence model demonstrates the best overall agreement with experimental data.

Implications of Enhanced Relative Humidity in Cold Tropical Cirrus

NASA Technical Reports Server (NTRS)

Jensen, Eric; Pfister, Leonhard

2004-01-01

In situ measurements of water vapor concentration and temperature in tropical cirrus during the CRYSTAL-FACE and Pre-AVE missions indicate that the steady-state relative humidity within cirrus at T less than 200 K is about 20-30% higher than ice saturation. These measurements challenge the conventional belief, that any water vapor in excess of ice saturation should be depleted by crystal growth given sufficient time. Detailed simulations of thin cirrus near the tropopause indicate that this enhanced steady-state relative humidity increases ice number densities, decreases crystal sizes and extends cloud lifetimes. The areal coverage of thin cirrus in the tropics is increased rather than decreased as indicated by simpler conceptual models. Perhaps most significantly, the increased steady-state H2O saturation mixing ratio over ice in thin cirrus near the tropopause results in about a 0.5-1 ppmv increase in the amount of water that can enter the stratosphere across the tropical tropopause cold trap. Hence, the enhanced steady-state relative humidity in cold cirrus implies that lower tropopause temperatures are required to explain the observed stratospheric water vapor mixing ratios than previously assumed.

Toward quantitative estimation of material properties with dynamic mode atomic force microscopy: a comparative study.

PubMed

Ghosal, Sayan; Gannepalli, Anil; Salapaka, Murti

2017-08-11

In this article, we explore methods that enable estimation of material properties with the dynamic mode atomic force microscopy suitable for soft matter investigation. The article presents the viewpoint of casting the system, comprising of a flexure probe interacting with the sample, as an equivalent cantilever system and compares a steady-state analysis based method with a recursive estimation technique for determining the parameters of the equivalent cantilever system in real time. The steady-state analysis of the equivalent cantilever model, which has been implicitly assumed in studies on material property determination, is validated analytically and experimentally. We show that the steady-state based technique yields results that quantitatively agree with the recursive method in the domain of its validity. The steady-state technique is considerably simpler to implement, however, slower compared to the recursive technique. The parameters of the equivalent system are utilized to interpret storage and dissipative properties of the sample. Finally, the article identifies key pitfalls that need to be avoided toward the quantitative estimation of material properties.

Sequence memory based on coherent spin-interaction neural networks.

PubMed

Xia, Min; Wong, W K; Wang, Zhijie

2014-12-01

Sequence information processing, for instance, the sequence memory, plays an important role on many functions of brain. In the workings of the human brain, the steady-state period is alterable. However, in the existing sequence memory models using heteroassociations, the steady-state period cannot be changed in the sequence recall. In this work, a novel neural network model for sequence memory with controllable steady-state period based on coherent spininteraction is proposed. In the proposed model, neurons fire collectively in a phase-coherent manner, which lets a neuron group respond differently to different patterns and also lets different neuron groups respond differently to one pattern. The simulation results demonstrating the performance of the sequence memory are presented. By introducing a new coherent spin-interaction sequence memory model, the steady-state period can be controlled by dimension parameters and the overlap between the input pattern and the stored patterns. The sequence storage capacity is enlarged by coherent spin interaction compared with the existing sequence memory models. Furthermore, the sequence storage capacity has an exponential relationship to the dimension of the neural network.

Study on the steady operating state of a micro-pulse electron gun.

PubMed

Kui, Zhou; Xiangyang, Lu; Shengwen, Quan; Jifei, Zhao; Xing, Luo; Ziqin, Yang

2014-09-01

Micro-pulse electron gun (MPG) employs the basic concept of multipacting to produce high-current and short-pulse electron beams from a radio-frequency (RF) cavity. The concept of MPG has been proposed for more than two decades. However, the unstable operating state of MPG vastly obstructs its practical applications. This paper presents a study on the steady operating state of a micro-pulse electron gun with theory and experiments. The requirements for the steady operating state are proposed through the analysis of the interaction between the RF cavity and the beam load. Accordingly, a MPG cavity with the frequency of 2856 MHz has been designed, constructed, and tested. Some primary experiments have been finished. Both the unstable and stable operating states of the MPG have been observed. The stable output beam current has been detected at about 3.8 mA. Further experimental study is under way now.

DYNGEN: A program for calculating steady-state and transient performance of turbojet and turbofan engines

NASA Technical Reports Server (NTRS)

Sellers, J. F.; Daniele, C. J.

1975-01-01

The DYNGEN, a digital computer program for analyzing the steady state and transient performance of turbojet and turbofan engines, is described. The DYNGEN is based on earlier computer codes (SMOTE, GENENG, and GENENG 2) which are capable of calculating the steady state performance of turbojet and turbofan engines at design and off-design operating conditions. The DYNGEN has the combined capabilities of GENENG and GENENG 2 for calculating steady state performance; to these the further capability for calculating transient performance was added. The DYNGEN can be used to analyze one- and two-spool turbojet engines or two- and three-spool turbofan engines without modification to the basic program. A modified Euler method is used by DYNGEN to solve the differential equations which model the dynamics of the engine. This new method frees the programmer from having to minimize the number of equations which require iterative solution. As a result, some of the approximations normally used in transient engine simulations can be eliminated. This tends to produce better agreement when answers are compared with those from purely steady state simulations. The modified Euler method also permits the user to specify large time steps (about 0.10 sec) to be used in the solution of the differential equations. This saves computer execution time when long transients are run. Examples of the use of the program are included, and program results are compared with those from an existing hybrid-computer simulation of a two-spool turbofan.

The effect of dissolve gas concentration in the initial growth stage of multi cavitation bubbles. Differences between vacuum degassing and ultrasound degassing.

PubMed

Yanagida, Hirotaka

2008-04-01

The sonochemical luminescence intensity from luminol was measured at a sampling rate of several kilohertz. This was noted at three different periods: first, the latent period in which no light emission occurs at all; second, the increased emission period from the start of light emission to the time when a steady state is reached; and third, the steady state period in which light emission occurs at the steady state value. When irradiated with ultrasound of different intensities, the times of the latent period and increased emission period are shorter for higher ultrasound intensities. To know how the dissolved oxygen content is involved in early-stage cavitation growth, an experiment was conducted using solutions with varying dissolved oxygen contents from 100% to 37%. For dissolved air content of 50% or less, it was found that the latent period was 30 times longer in a saturated condition. It was also found that the increased emission period was 10 times longer. However, the emission intensity in the steady state did not change at all even when the initial dissolved gas concentration of the sample was changed. From this, it was found that the reuse of collapsed bubbles takes place efficiently in the steady state. Dissolved oxygen was reduced by the use of a vacuum pump and by the degassing action of ultrasound, and it was discovered that the behavior of transient emission differed for the two ways of degassing.

Steady-state pharmacokinetics of isotretinoin and its 4-oxo metabolite: implications for fetal safety.

PubMed

Nulman, I; Berkovitch, M; Klein, J; Pastuszak, A; Lester, R S; Shear, N; Koren, G

1998-10-01

Isotretinoin is the most potent human teratogen on the market. Women for whom contraception fails may conceive during or soon after discontinuing isotretinoin therapy, making its elimination kinetics a crucial determinant of fetal safety. The steady-state pharmacokinetics of isotretinoin and its major 4-oxo metabolite were studied in 16 adult patients treated for acne who were receiving doses that ranged from 0.47 to 1.7 mg/kg daily. This is the first study of the pharmacokinetics of isotretinoin in women of childbearing age (n = 11). The clinical efficacy and tolerability of isotretinoin was investigated, and the correlation between these data and steady-state serum concentrations of isotretinoin was tested. The concentration-time data best fitted a two-compartment open model with linear elimination. There was no correlation between efficacy and tolerability of isotretinoin and steady-state serum concentrations. There was no correlation between dose of isotretinoin and steady-state concentration, due to the large variability in apparent clearance. Values for elimination half-life (t1/2) of isotretinoin and its metabolite were 29+/-40 hours and 22+/-10 hours, respectively. These data suggest a longer elimination t1/2 of the parent drug than previously reported. This is probably due to the longer sampling time used in this study (as long as 28 days). This study suggests that a greater variability exists in the safe time after discontinuation of the drug for onset of conception.

The Deformation of Polydimethylsiloxane (PDMS) Microfluidic Channels Filled with Embedded Circular Obstacles under Certain Circumstances.

PubMed

Roh, Changhyun; Lee, Jaewoong; Kang, Chankyu

2016-06-18

Experimental investigations were conducted to determine the influence of polydimethylsiloxane (PDMS) microfluidic channels containing aligned circular obstacles (with diameters of 172 µm and 132 µm) on the flow velocity and pressure drop under steady-state flow conditions. A significant PDMS bulging was observed when the fluid flow initially contacted the obstacles, but this phenomenon decreased in the 1 mm length of the microfluidic channels when the flow reached a steady-state. This implies that a microfluidic device operating with steady-state flows does not provide fully reliable information, even though less PDMS bulging is observed compared to quasi steady-state flow. Numerical analysis of PDMS bulging using ANSYS Workbench showed a relatively good agreement with the measured data. To verify the influence of PDMS bulging on the pressure drop and flow velocity, theoretical analyses were performed and the results were compared with the experimental results. The measured flow velocity and pressure drop data relatively matched well with the classical prediction under certain circumstances. However, discrepancies were generated and became worse as the microfluidic devices were operated under the following conditions: (1) restricted geometry of the microfluidic channels (i.e., shallow channel height, large diameter of obstacles and a short microchannel length); (2) operation in quasi-steady state flow; (3) increasing flow rates; and (4) decreasing amount of curing agent in the PDMS mixture. Therefore, in order to obtain reliable data a microfluidic device must be operated under appropriate conditions.

[Growth characteristics and control of iron bacteria on cast iron in drinking water distribution systems].

PubMed

Wang, Yang; Zhang, Xiao-Jian; Chen, Yu-Qiao; Lu, Pin-Pin; Chen, Chao

2009-11-01

This study investigated the growth characteristics of iron bacteria on cast iron and relationship between suspended and attached iron bacteria. The steady-state growth of iron bacteria would need 12 d and iron bacteria level in effluents increased 1 lg. Hydraulics influence on iron bacteria level and detachment rate of steady-state attached iron bacteria was not significant. But it could affect the time of attached iron bacteria on cast-iron coupons reaching to steady state. When the chlorine residual was 0.3 mg/L, the iron bacteria growth could be controlled effectively and suspended and attached iron bacteria levels both decreased 1 lg. When the chlorine residual was more than 1.0 mg/L, it could not inactivate the iron bacteria of internal corrosion scale yet. There was little effect on inhibiting the iron bacteria growth that the chlorine residual was 0.05 mg/L in drinking water quality standard of China. The iron bacteria on coupons reached to steady state without disinfectant and then increased the chlorine residual to 1.25 mg/L, the attached iron bacteria level could decrease 2 lg to 3 lg. Under steady-state, the suspended iron bacteria levels were linearly dependent on the attached iron bacteria. The control of iron bacteria in drinking water distribution systems was advanced: maintaining the chlorine residual (0.3 mg/L), flushing the pipeline with high dosage disinfectant, adopting corrosion-resistant pipe materials and renovating the old pipe loop.

Chemical-specific screening criteria for interpretation of biomonitoring data for volatile organic compounds (VOCs)--application of steady-state PBPK model solutions.

PubMed

Aylward, Lesa L; Kirman, Chris R; Blount, Ben C; Hays, Sean M

2010-10-01

The National Health and Nutrition Examination Survey (NHANES) generates population-representative biomonitoring data for many chemicals including volatile organic compounds (VOCs) in blood. However, no health or risk-based screening values are available to evaluate these data from a health safety perspective or to use in prioritizing among chemicals for possible risk management actions. We gathered existing risk assessment-based chronic exposure reference values such as reference doses (RfDs), reference concentrations (RfCs), tolerable daily intakes (TDIs), cancer slope factors, etc. and key pharmacokinetic model parameters for 47 VOCs. Using steady-state solutions to a generic physiologically-based pharmacokinetic (PBPK) model structure, we estimated chemical-specific steady-state venous blood concentrations across chemicals associated with unit oral and inhalation exposure rates and with chronic exposure at the identified exposure reference values. The geometric means of the slopes relating modeled steady-state blood concentrations to steady-state exposure to a unit oral dose or unit inhalation concentration among 38 compounds with available pharmacokinetic parameters were 12.0 microg/L per mg/kg-d (geometric standard deviation [GSD] of 3.2) and 3.2 microg/L per mg/m(3) (GSD=1.7), respectively. Chemical-specific blood concentration screening values based on non-cancer reference values for both oral and inhalation exposure range from 0.0005 to 100 microg/L; blood concentrations associated with cancer risk-specific doses at the 1E-05 risk level ranged from 5E-06 to 6E-02 microg/L. The distribution of modeled steady-state blood concentrations associated with unit exposure levels across VOCs may provide a basis for estimating blood concentration screening values for VOCs that lack chemical-specific pharmacokinetic data. The screening blood concentrations presented here provide a tool for risk assessment-based evaluation of population biomonitoring data for VOCs and are most appropriately applied to central tendency estimates for such datasets. Copyright (c) 2010 Elsevier Inc. All rights reserved.

Distinct findings from the steady-state analysis of a microbial model with time-invariant or seasonal driving forces

NASA Astrophysics Data System (ADS)

Wang, G.; Mayes, M. A.

2017-12-01

Microbially-explicit soil organic matter (SOM) decomposition models are thought to be more biologically realistic than conventional models. Current testing or evaluation of microbial models majorly uses steady-state analysis with time-invariant forces (i.e., soil temperature, moisture and litter input). The findings from such simplified analyses are assumed to be capable of representing the model responses in field soil conditions with seasonal driving forces. Here we show that the steady-state modeling results with seasonal forces may result in distinct findings from the simulations with time-invariant forcing data. We evaluate the response of soil organic C (SOC) to litter addition (L+) in a subtropical pine forest using the calibrated Microbial-ENzyme Decomposition (MEND) model. We implemented two sets of modeling analyses, with each set including two scenarios, i.e., control (CR) vs. litter-addition (L+). The first set (Set1) uses fixed soil temperature and moisture, and constant litter input under Scenario CR vs. increased constant litter input under Scenario L+. The second set (Set2) employs hourly soil temperature and moisture and monthly litter input under Scenario CR. Under Scenario L+ of Set2, A logistic function with an upper plateau represents the increasing trend of litter input to SOM. We conduct long-term simulations to ensure that the models reach steady-states for Set1 or dynamic equilibrium for Set2. Litter addition of Set2 causes an increase of SOC by 29%. However, the steady-state SOC pool sizes of Set1 would not respond to L+ as long as the chemical composition of litter remained the same. Our results indicate the necessity to implement dynamic model simulations with seasonal forcing data, which could lead to modeling results qualitatively different from the steady-state analysis with time-invariant forcing data.

A comparison of practical assessment methods to determine treadmill, cycle and elliptical ergometer VO2peak

PubMed Central

Mays, Ryan J.; Boér, Nicholas F.; Mealey, Lisa M.; Kim, Kevin H.; Goss, Fredric L.

2015-01-01

This investigation compared estimated and predicted peak oxygen consumption (VO2peak) and maximal heart rate (HRmax) among the treadmill, cycle ergometer and elliptical ergometer. Seventeen women (mean ± SE: 21.9 ± .3 yrs) exercised to exhaustion on all modalities. ACSM metabolic equations were used to estimate VO2peak. Digital displays on the elliptical ergometer were used to estimate VO2peak. Two individual linear regression methods were used to predict VO2peak: 1) two steady state heart rate (HR) responses up to 85% of age-predicted HRmax, and 2) multiple steady state/non-steady state HR responses up to 85% of age-predicted HRmax. Estimated VO2peak for the treadmill (46.3 ± 1.3 ml · kg−1 · min−1) and the elliptical ergometer (44.4 ± 1.0 ml · kg−1 · min−1) did not differ. The cycle ergometer estimated VO2peak (36.5 ± 1.0 ml · kg−1 · min−1) was lower (p < .001) than the estimated VO2peak values for the treadmill and elliptical ergometer. Elliptical ergometer VO2peak predicted from steady state (51.4 ± .8 ml · kg−1 · min−1) and steady state/non-steady state (50.3 ± 2.0 ml · kg−1 · min−1) models were higher than estimated elliptical ergometer VO2peak, p < .01. HRmax and estimates of VO2peak were similar between the treadmill and elliptical ergometer, thus cross-modal exercise prescriptions may be generated. The use of digital display estimates of submaximal oxygen uptake for the elliptical ergometer may not be an accurate method for predicting VO2peak. Health-fitness professionals should use caution when utilizing submaximal elliptical ergometer digital display estimates to predict VO2peak. PMID:20393357

A cross-bridge based model of force depression: Can a single modification address both transient and steady-state behaviors?

PubMed

Corr, David T; Herzog, Walter

2016-03-21

Force depression (FD), the reduction of isometric force following active shortening, is a phenomenon of skeletal muscle that has received significant attention in biomechanical and physiological literature, yet the mechanisms underlying FD remain unknown. Recent experiments identified a slower rate of force redevelopment with increasing amounts of steady-state FD, suggesting that FD may be caused, at least in part, by a decrease in cross-bridge binding rate (Corr and Herzog, 2005; Koppes et al., 2014). Herein, we develop a cross-bridge based model of FD in which the binding rate function, f, decreases with the mechanical work performed during shortening. This modification incorporates a direct relationship between steady-state FD and muscle mechanical work (Corr and Herzog, 2005; Herzog et al., 2000; Kosterina et al., 2008), and is consistent with a proposed mechanism attributing FD to stress-induced inhibition of cross-bridge attachments (Herzog, 1998; Maréchal and Plaghki, 1979). Thus, for an increase in mechanical work, the model should predict a slower force redevelopment (decreased attachment rate) to a more depressed steady-state force (fewer attached cross-bridges), and a reduction in contractile element stiffness (Ford et al., 1981). We hypothesized that since this modification affects the cross-bridge kinetics, a corresponding model would be able to account for both transient and steady-state FD behaviors. Comparisons to prior experiments (Corr and Herzog, 2005; Herzog et al., 2000; Kosterina et al., 2008) show that both steady-state and transient aspects of FD, as well as the relationship of FD with respect to speed and amplitude of shortening, are well captured by this model. Thus, this relatively simple cross-bridge based model of FD lends support to a mechanism involving the inhibition of cross-bridge binding, and indicates that cross-bridge kinetics may play a critical role in FD. Copyright © 2016 Elsevier Ltd. All rights reserved.

Global Asymptotic Behavior of Iterative Implicit Schemes

NASA Technical Reports Server (NTRS)

Yee, H. C.; Sweby, P. K.

1994-01-01

The global asymptotic nonlinear behavior of some standard iterative procedures in solving nonlinear systems of algebraic equations arising from four implicit linear multistep methods (LMMs) in discretizing three models of 2 x 2 systems of first-order autonomous nonlinear ordinary differential equations (ODEs) is analyzed using the theory of dynamical systems. The iterative procedures include simple iteration and full and modified Newton iterations. The results are compared with standard Runge-Kutta explicit methods, a noniterative implicit procedure, and the Newton method of solving the steady part of the ODEs. Studies showed that aside from exhibiting spurious asymptotes, all of the four implicit LMMs can change the type and stability of the steady states of the differential equations (DEs). They also exhibit a drastic distortion but less shrinkage of the basin of attraction of the true solution than standard nonLMM explicit methods. The simple iteration procedure exhibits behavior which is similar to standard nonLMM explicit methods except that spurious steady-state numerical solutions cannot occur. The numerical basins of attraction of the noniterative implicit procedure mimic more closely the basins of attraction of the DEs and are more efficient than the three iterative implicit procedures for the four implicit LMMs. Contrary to popular belief, the initial data using the Newton method of solving the steady part of the DEs may not have to be close to the exact steady state for convergence. These results can be used as an explanation for possible causes and cures of slow convergence and nonconvergence of steady-state numerical solutions when using an implicit LMM time-dependent approach in computational fluid dynamics.

The relationship between nighttime formation of gaseous HONO and nocturnal stability in an urban environment

NASA Astrophysics Data System (ADS)

McLaren, Robert; Wojtal, Patryk; Taylor, Peter

2014-05-01

Nitrous acid (HONO) is an important radical precursor in the troposphere that accumulates overnight giving rise to a significant photolytic production of the hydroxyl radical, OH, in the boundary layer during early morning hours the next day. It is understood that HONO is formed in the dark through the heterogeneous hydrolysis of NO2 on surfaces (2 NO2+ H2O -> HONO + HNO3) in a first order process, largely dominated by hydrolysis on ground surfaces and a smaller contribution from aerosol surfaces. Despite progress, the dark heterogeneous mechanism of HONO formation is still not well understood, mirroring our lack of consensus on the daytime production of HONO. We have measured HONO at night in an urban area (York University, Toronto, Canada) by DOAS for over one year. This rich dataset was analyzed with a view to understanding the nocturnal formation mechanism, and possible links to the daytime HONO formation mechanism. Frequently, "steady-states" of HONO are observed at night; d[HONO]/dt ~ 0, which follow after a rapid buildup of HONO during sunset at rates of several ppb hr-1. These steady-state levels of HONO are found to be independent of the mixing ratio of NO2 throughout the night. On other occasions, steady-states are not observed and HONO continues to increase throughout the night, highly correlated with the levels of NO2 d([HONO]/[NO2])/dt ~ 0). We have found that a very significant predictor of the type of behavior is the nocturnal stability of the atmosphere, measured by the thermal gradient, ΔT=T9.5m-T1.0m, and wind speed. The steady-state behavior is found to occur almost exclusively on unstable nights with higher wind speeds and ΔT ~ 0, when mixing of air in the lower atmosphere is more efficient. The non steady-state behavior of HONO is observed on stable nights with low wind speeds and large thermal gradients, ΔT > 2oC indicating limited vertical mixing. The observation of NO2 independent steady-states of HONO under conditions of efficient nocturnal mixing suggest that the steady-state may result from an equilibrium between a surface reservoir source of HONO, reminiscent of those observed in the polluted marine boundary layer at night (Wojtal et al., Atmos. Chem. Phys., 11, 3243-3261, 2011).

A fission-fusion hybrid reactor in steady-state L-mode tokamak configuration with natural uranium

DOE Office of Scientific and Technical Information (OSTI.GOV)

Reed, Mark; Parker, Ronald R.; Forget, Benoit

2012-06-19

This work develops a conceptual design for a fusion-fission hybrid reactor operating in steady-state L-mode tokamak configuration with a subcritical natural or depleted uranium pebble bed blanket. A liquid lithium-lead alloy breeds enough tritium to replenish that consumed by the D-T fusion reaction. The fission blanket augments the fusion power such that the fusion core itself need not have a high power gain, thus allowing for fully non-inductive (steady-state) low confinement mode (L-mode) operation at relatively small physical dimensions. A neutron transport Monte Carlo code models the natural uranium fission blanket. Maximizing the fission power gain while breeding sufficient tritiummore » allows for the selection of an optimal set of blanket parameters, which yields a maximum prudent fission power gain of approximately 7. A 0-D tokamak model suffices to analyze approximate tokamak operating conditions. This fission blanket would allow the fusion component of a hybrid reactor with the same dimensions as ITER to operate in steady-state L-mode very comfortably with a fusion power gain of 6.7 and a thermal fusion power of 2.1 GW. Taking this further can determine the approximate minimum scale for a steady-state L-mode tokamak hybrid reactor, which is a major radius of 5.2 m and an aspect ratio of 2.8. This minimum scale device operates barely within the steady-state L-mode realm with a thermal fusion power of 1.7 GW. Basic thermal hydraulic analysis demonstrates that pressurized helium could cool the pebble bed fission blanket with a flow rate below 10 m/s. The Brayton cycle thermal efficiency is 41%. This reactor, dubbed the Steady-state L-mode non-Enriched Uranium Tokamak Hybrid (SLEUTH), with its very fast neutron spectrum, could be superior to pure fission reactors in terms of breeding fissile fuel and transmuting deleterious fission products. It would likely function best as a prolific plutonium breeder, and the plutonium it produces could actually be more proliferation-resistant than that bred by conventional fast reactors. Furthermore, it can maintain constant total hybrid power output as burnup proceeds by varying the neutron source strength.« less

Modeling transitions in body composition: the approach to steady state for anthropometric measures and physiological functions in the Minnesota human starvation study

PubMed Central

Hargrove, James L; Heinz, Grete; Heinz, Otto

2008-01-01

Background This study evaluated whether the changes in several anthropometric and functional measures during caloric restriction combined with walking and treadmill exercise would fit a simple model of approach to steady state (a plateau) that can be solved using spreadsheet software (Microsoft Excel®). We hypothesized that transitions in waist girth and several body compartments would fit a simple exponential model that approaches a stable steady-state. Methods The model (an equation) was applied to outcomes reported in the Minnesota starvation experiment using Microsoft Excel's Solver® function to derive rate parameters (k) and projected steady state values. However, data for most end-points were available only at t = 0, 12 and 24 weeks of caloric restriction. Therefore, we derived 2 new equations that enable model solutions to be calculated from 3 equally spaced data points. Results For the group of male subjects in the Minnesota study, body mass declined with a first order rate constant of about 0.079 wk-1. The fractional rate of loss of fat free mass, which includes components that remained almost constant during starvation, was 0.064 wk-1, compared to a rate of loss of fat mass of 0.103 wk-1. The rate of loss of abdominal fat, as exemplified by the change in the waist girth, was 0.213 wk-1. On average, 0.77 kg was lost per cm of waist girth. Other girths showed rates of loss between 0.085 and 0.131 wk-1. Resting energy expenditure (REE) declined at 0.131 wk-1. Changes in heart volume, hand strength, work capacity and N excretion showed rates of loss in the same range. The group of 32 subjects was close to steady state or had already reached steady state for the variables under consideration at the end of semi-starvation. Conclusion When energy intake is changed to new, relatively constant levels, while physical activity is maintained, changes in several anthropometric and physiological measures can be modeled as an exponential approach to steady state using software that is widely available. The 3 point method for parameter estimation provides a criterion for testing whether change in a variable can be usefully modelled with exponential kinetics within the time range for which data are available. PMID:18840293

Steady-State Cycle Deck Launcher Developed for Numerical Propulsion System Simulation

NASA Technical Reports Server (NTRS)

VanDrei, Donald E.

1997-01-01

One of the objectives of NASA's High Performance Computing and Communications Program's (HPCCP) Numerical Propulsion System Simulation (NPSS) is to reduce the time and cost of generating aerothermal numerical representations of engines, called customer decks. These customer decks, which are delivered to airframe companies by various U.S. engine companies, numerically characterize an engine's performance as defined by the particular U.S. airframe manufacturer. Until recently, all numerical models were provided with a Fortran-compatible interface in compliance with the Society of Automotive Engineers (SAE) document AS681F, and data communication was performed via a standard, labeled common structure in compliance with AS681F. Recently, the SAE committee began to develop a new standard: AS681G. AS681G addresses multiple language requirements for customer decks along with alternative data communication techniques. Along with the SAE committee, the NPSS Steady-State Cycle Deck project team developed a standard Application Program Interface (API) supported by a graphical user interface. This work will result in Aerospace Recommended Practice 4868 (ARP4868). The Steady-State Cycle Deck work was validated against the Energy Efficient Engine customer deck, which is publicly available. The Energy Efficient Engine wrapper was used not only to validate ARP4868 but also to demonstrate how to wrap an existing customer deck. The graphical user interface for the Steady-State Cycle Deck facilitates the use of the new standard and makes it easier to design and analyze a customer deck. This software was developed following I. Jacobson's Object-Oriented Design methodology and is implemented in C++. The AS681G standard will establish a common generic interface for U.S. engine companies and airframe manufacturers. This will lead to more accurate cycle models, quicker model generation, and faster validation leading to specifications. The standard will facilitate cooperative work between industry and NASA. The NPSS Steady-State Cycle Deck team released a batch version of the Steady-State Cycle Deck in March 1996. Version 1.1 was released in June 1996. During fiscal 1997, NPSS accepted enhancements and modifications to the Steady-State Cycle Deck launcher. Consistent with NPSS' commercialization plan, these modifications will be done by a third party that can provide long-term software support.

Applications and interpretation of krypton 81m ventilation/technetium 99m macroaggregate perfusion lung scanning in childhood

NASA Astrophysics Data System (ADS)

Davies, Hugh Trevor Frimston

Radionuclide ventilation perfusion lung scans now play an important part in the investigation of paediatric lung disease, providing a safe, noninvasive assessment of regional lung function in children with suspected pulmonary disease. In paediatric practice the most suitable radionuclides are Krypton 81m (Kr81m) and Technetium 99m (Tc99m), which are jointly used in the Kr81m ventilation/Tc99m macroaggregate perfusion lung scan (V/Q lung scan). The Kr81m ventilation scan involves a low radiation dose, requires little or no subject cooperation and because of the very short half life of Kr81m (13 seconds) the steady state image acquired during continuous inhalation of the radionuclide is considered to reflect regional distribution of ventilation. It is now the most important noninvasive method available for the investigation of the regional abnormalities of ventilation characteristic of many congenital and acquired paediatric respiratory diseases, such as diaphragmatic hernia, pulmonary sequestration, bronchopulmonary dysplasia, foreign body inhalation and bronchiectasis. It improves diagnostic accuracy, aids clinical decision making and is used to monitor the progress of disease and response to therapy. Theoretical analysis of the steady state Kr81m ventilation image suggests that it may only reflect regional ventilation when specific ventilation (ventilation per unit volume of lung) is within or below the normal adult range (1-3 L/L/min). At higher values such as those seen in neonates and infants (8-15 L/L/min) Kr81m activity may reflect regional lung volume rather than ventilation, a conclusion supported by the studies of Ciofetta et al. There is some controversy on this issue as animal studies have demonstrated that the Kr81m image reflects ventilation over a much wider range of specific ventilation (up to 13 L/L/min). A clinical study of sick infants and very young children is in agreement with this animal work and suggests that the steady state Kr81m image still reflects regional ventilation in this age group. The doubt cast on the interpretation of the Kr81m steady state image could limit the value of V/Q lung scans in following regional lung function through childhood, a period when specific ventilation is falling rapidly as the child grows. Therefore the first aim of this study was to examine the application of this theoretical model to children and determine whether the changing specific ventilation seen through childhood significantly alters the interpretation of the steady state Kr81m image. This is a necessary first step before conducting longitudinal studies of regional ventilation and perfusion in children. The effect of posture on regional ventilation and perfusion in the adult human lung has been extensively studied. Radiotracer studies have consistently shown that both ventilation and perfusion are preferentially distributed to dependent lung regions during tidal breathing regardless of posture. There is little published information concerning the pattern in children yet there are many differences in lung and chest wall mechanics of children and adults which, along with clinical observation, have led to the hypothesis that the pattern of regional ventilation observed in adults may not be seen in children. Recent reports of regional ventilation in infants and very young children have provided support for this theory. The paper of Heaf et al demonstrated that these differences may in certain circumstances be clinically important. It is not clear however at what age children adopt the "adult pattern of ventilation". In addition to the problems referred to above, attenuation of Kr81m activity as it passes through the chest wall and the changing geometry of the chest during tidal breathing have made quantitative analysis of the image difficult although fractional ventilation and perfusion to each lung can be calculated from the steady state image. In clinical practise, therefore, ventilation and perfusion are usually assessed by inspection of the steady state image. The aims of the present study were therefore: 1. To critically assess Kr81m ventilation and Tc99m MAA perfusion images in children. 2. To derive fractional ventilation and perfusion to each lung in children with normal chest radiography and homogeneous distribution of the radionuclides. 3. To conduct further studies into the effects of gravity on regional lung function. 4. To apply the technique in clinical practise. 5. To attempt to improve quantitation of the Kr81m ventilation image.

Steady-state bumpless transfer under controller uncertainty using the state/output feedback topology

DOE Office of Scientific and Technical Information (OSTI.GOV)

Zheng, K.; Lee, A.H.; Bentsman, J.

2006-01-15

Linear quadratic (LQ) bumpless transfer design introduced recently by Turner and Walker gives a very convenient and straightforward computational procedure for the steady-state bumpless transfer operator synthesis. It is, however, found to be incapable of providing convergence of the output of the offline controller to that of the online controller in several industrial applications, producing bumps in the plant output in the wake of controller transfer. An examination of this phenomenon reveals that the applications in question are characterized by a significant mismatch, further referred to as controller uncertainty, between the dynamics of the implemented controllers and their models usedmore » in the transfer operator computation. To address this problem, while retaining the convenience of the Turner and Walker design, a novel state/output feedback bumpless transfer topology is introduced that employs the nominal state of the offline controller and, through the use of an additional controller/model mismatch compensator, also the offline controller output. A corresponding steady-state bumpless transfer design procedure along with the supporting theory is developed for a large class of systems. Due to these features, it is demonstrated to solve a long-standing problem of high-quality steady-state bumpless transfer from the industry standard low-order nonlinear multiloop PID-based controllers to the modern multiinput-multioutput (MIMO) robust controllers in the megawatt/throttle pressure control of a typical coal-fired boiler/turbine unit.« less

A new method to obtain narrowband emission from a broadband current using increased impedance of plasma-like media (Conference Presentation)

NASA Astrophysics Data System (ADS)

Hur, Min Sup; Ersfeld, Bernhard; Noble, Adam; Suk, Hyyong; Jaroszynski, Dino A.

2017-05-01

In conventional radiation sources, narrowband radiation emission can be obtained by narrowband current oscillation. Usually the spectrum of the oscillating current is made narrow by a large or complicated structure for wave-particle interaction. One good example is the beam-undulator system. In this presentation, we introduce a new method to obtain a radiation emission with a well-collimated frequency without changing the broadband nature of a given current source. The method is based on our recent discovery of the new physical properties of the cut-off phenomenon, which broadly exists in general plasma-like media, such as plasma, waveguide, or photonic crystal, etc. A common feature of these media is the Bohm-Gross dispersion relation, which has a frequency condition to make the wavenumber zero. In the zero-wavenumber state, an electromagnetic wave cannot propagate through the medium, but instead, is reflected (i.e. cut-off). In regular steady-state analysis, the cut-off condition is characterized by infinite radiation impedance. An interesting question here is what would happen to the radiation power, if a non-zero current oscillating with the cut-off frequency were enforced in a medium (a current source, in contrast with the regular voltage source). A regular steady-state analysis for this situation leads to infinite power of radiation from Ohm's law. We could solve such a paradoxical situation by analyzing the non-steady-state system; we found that the system can be described by a time-dependent Schroedinger equation with an external driving term. The solution of this equation shows a temporally growing electromagnetic field. When this concept is extended to a generally broadband current source, the spectral density at the cut-off frequency can be selectively enhanced (selectively enhanced emission, SEE). Hence a general broadband radiation source can be easily converted to a narrowband source by enclosing the system with a plasma-like medium. The current source seems to exist in many radiation systems with a low driver-to-emission efficiency. When the current is determined predominantly by the driver (for examples, laser pulses), while the feedback from the emitted field is weak, such current can be considered as a quasi-current source, We present a few examples (mostly from PIC simulations) to demonstrate the SEE; two-color-driven THz system enclosed by a tapered waveguide, THz emission from a magnetized plasma, and re-interpretation of experimental data. Those examples show that quasi-current source can be found in practical systems, and the SEE mechanism works.

SPH non-Newtonian Model for Ice Sheet and Ice Shelf Dynamics

DOE Office of Scientific and Technical Information (OSTI.GOV)

Tartakovsky, Alexandre M.; Pan, Wenxiao; Monaghan, Joseph J.

2012-07-07

We propose a new three-dimensional smoothed particle hydrodynamics (SPH) non-Newtonian model to study coupled ice sheet and ice shelf dynamics. Most existing ice sheet numerical models use a grid-based Eulerian approach, and are usually restricted to shallow ice sheet and ice shelf approximations of the momentum conservation equation. SPH, a fully Lagrangian particle method, solves the full momentum conservation equation. SPH method also allows modeling of free-surface flows, large material deformation, and material fragmentation without employing complex front-tracking schemes, and does not require re-meshing. As a result, SPH codes are highly scalable. Numerical accuracy of the proposed SPH model ismore » first verified by simulating a plane shear flow with a free surface and the propagation of a blob of ice along a horizontal surface. Next, the SPH model is used to investigate the grounding line dynamics of ice sheet/shelf. The steady position of the grounding line, obtained from our SPH simulations, is in good agreement with laboratory observations for a wide range of bedrock slopes, ice-to-fluid density ratios, and flux. We examine the effect of non-Newtonian behavior of ice on the grounding line dynamics. The non-Newtonian constitutive model is based on Glen's law for a creeping flow of a polycrystalline ice. Finally, we investigate the effect of a bedrock geometry on a steady-state position of the grounding line.« less

Effects of subglottal and supraglottal acoustic loading on voice production

NASA Astrophysics Data System (ADS)

Zhang, Zhaoyan; Mongeau, Luc; Frankel, Steven

2002-05-01

Speech production involves sound generation by confined jets through an orifice (the glottis) with a time-varying area. Predictive models are usually based on the quasi-steady assumption. This assumption allows the complex unsteady flows to be treated as steady flows, which are more effectively modeled computationally. Because of the reflective properties of the human lungs, trachea and vocal tract, subglottal and supraglottal resonance and other acoustic effects occur in speech, which might affect glottal impedance, especially in the regime of unsteady flow separation. Changes in the flow structure, or flow regurgitation due to a transient negative transglottal pressure, could also occur. These phenomena may affect the quasi-steady behavior of speech production. To investigate the possible effects of the subglottal and supraglottal acoustic loadings, a dynamic mechanical model of the larynx was designed and built. The subglottal and supraglottal acoustic loadings are simulated using an expansion in the tube upstream of the glottis and a finite length tube downstream, respectively. The acoustic pressures of waves radiated upstream and downstream of the orifice were measured and compared to those predicted using a model based on the quasi-steady assumption. A good agreement between the experimental data and the predictions was obtained for different operating frequencies, flow rates, and orifice shapes. This supports the validity of the quasi-steady assumption for various subglottal and supraglottal acoustic loadings.

Feature-based data assimilation in geophysics

NASA Astrophysics Data System (ADS)

Morzfeld, Matthias; Adams, Jesse; Lunderman, Spencer; Orozco, Rafael

2018-05-01

Many applications in science require that computational models and data be combined. In a Bayesian framework, this is usually done by defining likelihoods based on the mismatch of model outputs and data. However, matching model outputs and data in this way can be unnecessary or impossible. For example, using large amounts of steady state data is unnecessary because these data are redundant. It is numerically difficult to assimilate data in chaotic systems. It is often impossible to assimilate data of a complex system into a low-dimensional model. As a specific example, consider a low-dimensional stochastic model for the dipole of the Earth's magnetic field, while other field components are ignored in the model. The above issues can be addressed by selecting features of the data, and defining likelihoods based on the features, rather than by the usual mismatch of model output and data. Our goal is to contribute to a fundamental understanding of such a feature-based approach that allows us to assimilate selected aspects of data into models. We also explain how the feature-based approach can be interpreted as a method for reducing an effective dimension and derive new noise models, based on perturbed observations, that lead to computationally efficient solutions. Numerical implementations of our ideas are illustrated in four examples.

Current distribution in a three-dimensional IC analyzed by a perturbation method. Part 1: A simple steady state theory

NASA Technical Reports Server (NTRS)

Edmonds, Larry D.

1987-01-01

The steady state current distribution in a three dimensional integrated circuit is presented. A device physics approach, based on a perturbation method rather than an equivalent lumped circuit approach, is used. The perturbation method allows the various currents to be expressed in terms of elementary solutions which are solutions to very simple boundary value problems. A Simple Steady State Theory is the subtitle because the most obvious limitation of the present version of the analysis is that all depletion region boundary surfaces are treated as equipotential surfaces. This may be an adequate approximation in some applications but it is an obvious weakness in the theory when applied to latched states. Examples that illustrate the use of these analytical methods are not given because they will be presented in detail in the future.

Quantum cooling and squeezing of a levitating nanosphere via time-continuous measurements

NASA Astrophysics Data System (ADS)

Genoni, Marco G.; Zhang, Jinglei; Millen, James; Barker, Peter F.; Serafini, Alessio

2015-07-01

With the purpose of controlling the steady state of a dielectric nanosphere levitated within an optical cavity, we study its conditional dynamics under simultaneous sideband cooling and additional time-continuous measurement of either the output cavity mode or the nanosphere’s position. We find that the average phonon number, purity and quantum squeezing of the steady-states can all be made more non-classical through the addition of time-continuous measurement. We predict that the continuous monitoring of the system, together with Markovian feedback, allows one to stabilize the dynamics for any value of the laser frequency driving the cavity. By considering state of the art values of the experimental parameters, we prove that one can in principle obtain a non-classical (squeezed) steady-state with an average phonon number {n}{ph}≈ 0.5.

Secondary organic aerosol from ozone-initiated reactions with terpene-rich household products

NASA Astrophysics Data System (ADS)

Coleman, Beverly K.; Lunden, Melissa M.; Destaillats, Hugo; Nazaroff, William W.

We analyzed secondary organic aerosol (SOA) data from a series of small-chamber experiments in which terpene-rich vapors from household products were combined with ozone under conditions analogous to product use indoors. Reagents were introduced into a continuously ventilated 198 L chamber at steady rates. Consistently, at the time of ozone introduction, nucleation occurred exhibiting similar behavior to atmospheric events. The initial nucleation burst and growth was followed by a period in which approximately stable particle levels were established, reflecting a balance between new particle formation, condensational growth, and removal by ventilation. Airborne particles were measured with a scanning mobility particle sizer (SMPS, 10-400 nm) in every experiment and with an optical particle counter (OPC, 0.1-2.0 μm) in a subset. Parameters for a three-mode lognormal fit to the size distribution at steady state were determined for each experiment. Increasing the supply ozone level increased the steady-state mass concentration and yield of SOA from each product tested. Decreasing the air-exchange rate increased the yield. The steady-state fine-particle mass concentration (PM 1.1) ranged from 10 to >300 μg m -3 and yields ranged from 5% to 37%. Steady-state nucleation rates and SOA mass formation rates were ˜10 cm -3 s -1 and ˜10 μg m -3 min -1, respectively.

Secondary organic aerosol from ozone-initiated reactions with terpene-rich household products

DOE Office of Scientific and Technical Information (OSTI.GOV)

Coleman, Beverly; Coleman, Beverly K.; Lunden, Melissa M.

2008-01-01

We analyzed secondary organic aerosol (SOA) data from a series of small-chamber experiments in which terpene-rich vapors from household products were combined with ozone under conditions analogous to product use indoors. Reagents were introduced into a continuously ventilated 198 L chamber at steady rates. Consistently, at the time of ozone introduction, nucleation occurred exhibiting behavior similar to atmospheric events. The initial nucleation burst and growth was followed by a period in which approximately stable particle levels were established reflecting a balance between new particle formation, condensational growth, and removal by ventilation. Airborne particles were measured with a scanning mobility particlemore » sizer (SMPS, 10 to 400 nm) in every experiment and with an optical particle counter (OPC, 0.1 to 2.0 ?m) in a subset. Parameters for a three-mode lognormal fit to the size distribution at steady state were determined for each experiment. Increasing the supply ozone level increased the steady-state mass concentration and yield of SOA from each product tested. Decreasing the air-exchange rate increased the yield. The steady-state fine-particle mass concentration (PM1.1) ranged from 10 to> 300 mu g m-3 and yields ranged from 5percent to 37percent. Steady-state nucleation rates and SOA mass formation rates were on the order of 10 cm-3 s-1 and 10 mu g m-3 min-1, respectively.« less

Variability simulations with a steady, linearized primitive equations model

NASA Technical Reports Server (NTRS)

Kinter, J. L., III; Nigam, S.

1985-01-01

Solutions of the steady, primitive equations on a sphere, linearized about a zonally symmetric basic state are computed for the purpose of simulating monthly mean variability in the troposphere. The basic states are observed, winter monthly mean, zonal means of zontal and meridional velocities, temperatures and surface pressures computed from the 15 year NMC time series. A least squares fit to a series of Legendre polynomials is used to compute the basic states between 20 H and the equator, and the hemispheres are assumed symmetric. The model is spectral in the zonal direction, and centered differences are employed in the meridional and vertical directions. Since the model is steady and linear, the solution is obtained by inversion of a block, pente-diagonal matrix. The model simulates the climatology of the GFDL nine level, spectral general circulation model quite closely, particularly in middle latitudes above the boundary layer. This experiment is an extension of that simulation to examine variability of the steady, linear solution.

Dissipative structure in the photo-induced phase under steady light irradiation in the spin crossover complex.

PubMed

Nishihara, Taishi; Bousseksou, Azzdine; Tanaka, Koichiro

2013-12-16

We report the spatial and temporal dynamics of the photo-induced phase in the iron (II) spin crossover complex Fe(ptz)(6)(BF(4))(2) studied by image measurement under steady light irradiation and transient absorption measurement. The dynamic factors are derived from the spatial and temporal fluctuation of the image in the steady state under light irradiation between 65 and 100 K. The dynamic factors clearly indicate that the fluctuation has a resonant frequency that strongly depends on the temperature, and is proportional to the relaxation rate of the photo-induced phase. This oscillation of the speckle pattern under steady light irradiation is ascribed to the nonlinear interaction between the spin state and the lattice volume at the surface.

What Polar Bears Can Teach Us about Mission Creep

DTIC Science & Technology

2015-04-16

or Phase 0 operations. Mission Creep, the expansion of a project or mission beyond its original goals, is often an outcome of such steady state...state or Phase 0 operations. Mission Creep, the expansion of a project or mission beyond its original goals, is often an outcome of such steady state...de Tocqueville Mission Creep is the expansion of an operation or mission beyond its original goals, often after initial success. It occurs when

Combined Steady-State and Dynamic Heat Exchanger Experiment

ERIC Educational Resources Information Center

Luyben, William L.; Tuzla, Kemal; Bader, Paul N.

2009-01-01

This paper describes a heat-transfer experiment that combines steady-state analysis and dynamic control. A process-water stream is circulated through two tube-in-shell heat exchangers in series. In the first, the process water is heated by steam. In the second, it is cooled by cooling water. The equipment is pilot-plant size: heat-transfer areas…

Magnetic Resonance Arterial Spin Tagging for Noninvasive Pharmacokinetic Analysis of Breast Cancer

DTIC Science & Technology

1998-10-01

TIbr () - TIbr (j) and 1 In (Sreg - Sno (i)) - In (Sreg - Snon(J)) (1.9) Ti. Tlb, Wi - Tlbr W) where Sreg = the average steady-state signal intensity at...a pixel under the Regular Condition, Tlbr (i) = the ith effective inversion time (TI) (used for the ith image), Ssel(i) = the steady-state signal

Mechanistic assessment of hillslope transpiration controls of diel subsurface flow: a steady-state irrigation approach

Treesearch

H.R. Barnard; C.B. Graham; W.J. van Verseveld; J.R. Brooks; B.J. Bond; J.J. McDonnell

2010-01-01

Mechanistic assessment of how transpiration influences subsurface flow is necessary to advance understanding of catchment hydrology. We conducted a 24-day, steady-state irrigation experiment to quantify the relationships among soil moisture, transpiration and hillslope subsurface flow. Our objectives were to: (1) examine the time lag between maximum transpiration and...

Existence and uniqueness of steady state solutions of a nonlocal diffusive logistic equation

NASA Astrophysics Data System (ADS)

Sun, Linan; Shi, Junping; Wang, Yuwen

2013-08-01

In this paper, we consider a dynamical model of population biology which is of the classical Fisher type, but the competition interaction between individuals is nonlocal. The existence, uniqueness, and stability of the steady state solution of the nonlocal problem on a bounded interval with homogeneous Dirichlet boundary conditions are studied.

78 FR 29393 - University of Missouri-Columbia Facility Operating License No. R-103

Federal Register 2010, 2011, 2012, 2013, 2014

2013-05-20

... Curators of the University of Missouri--Columbia (the licensee) to operate the Missouri University Research Reactor (MURR) at a maximum steady-state thermal power of 10 megawatts (MW). The renewed license would authorize the licensee to operate the MURR up to a steady-state thermal power of 10 MW for an additional 20...

REAL-TIME EMISSION CHARACTERIZATION OF ORGANIC AIR TOXIC POLLUTANTS DURING STEADY STATE AND TRANSIENT OPERATION OF A MEDIUM DUTY DIESEL ENGINE

EPA Science Inventory

An on-line monitoring method, jet resonance-enhanced multi-photon ionization (REMPI) with time-of-flight mass spectrometry (TOFMS) was used to measure emissions of organic air toxics from a medium-duty (60 kW)diesel generator during transient and steady state operations. Emission...

New steady-state models for water-limited cropping systems using saline irrigation waters: Analytical solutions and applications

USDA-ARS?s Scientific Manuscript database

Due to the diminishing availability of good quality water for irrigation, it is increasingly important that irrigation and salinity management tools be able to target submaximal crop yields and support the use of marginal quality waters. In this work, we present a steady-state irrigated systems mod...

New steady-state models for water-limited cropping systems using saline irrigation waters: Analytical solutions and applications

USDA-ARS?s Scientific Manuscript database

Due to the diminishing availability of good quality water for irrigation, it is increasingly important that irrigation and salinity management tools be able to target submaximal crop yields and support the use of marginal quality waters. In this work, we present a steady-state irrigated systems mode...

Steady State Load Characterization Fact Sheet: 2012 Chevy Volt

DOE Office of Scientific and Technical Information (OSTI.GOV)

Scoffield, Don

2015-03-01

This fact sheet characterizes the steady state charging behavior of a 2012 Chevy Volt. Both level 1 charging (120 volt) and level 2 charging (208 volts) is investigated. This fact sheet contains plots of efficiency, power factor, and current harmonics as vehicle charging is curtailed. Prominent current harmonics are also displayed in a histogram for various charge rates.

Walkway Length Determination for Steady State Walking in Young and Older Adults

ERIC Educational Resources Information Center

Macfarlane, Pamela A.; Looney, Marilyn A.

2008-01-01

The primary purpose of this study was to determine acceleration (AC) and deceleration (DC) distances that would accommodate young and older adults walking at their preferred and fast speeds. A secondary purpose was to determine the minimal walkway length needed to record six steady state (SS) steps (three full gait cycles) for younger and older…

Programmable calculator uses equation to figure steady-state gas-pipeline flow

DOE Office of Scientific and Technical Information (OSTI.GOV)

Holmberg, E.

Because it is accurate and consistent over a wide range of variables, the Colebrook-White (C-W) formula serves as the basis for many methods of calculating turbulent flow in gas pipelines. Oilconsult reveals a simple way to adapt the C-W formula to calculate steady-state pipeline flow using the TI-59 programmable calculator.

Time- and Space-Resolved Spectroscopic Investigation on Pi-Conjugated Nanostructures - 2

DTIC Science & Technology

2016-01-12

15. SUBJECT TERMS Materials Characterization, Materials Chemistry, Nonlinear Optical Materials, Spectroscopy 16. SECURITY CLASSIFICATION...nanostructures will translate into new ground-breaking developments that not only allow the structure-property relationships to be probed in greater detail... spectroscopy . I. Experimental method 1. Steady-state Spectroscopy - UV-Vis-NIR Absorption & Emission Steady-state Spectroscopy - NIR

General purpose computer programs for numerically analyzing linear ac electrical and electronic circuits for steady-state conditions

NASA Technical Reports Server (NTRS)

Egebrecht, R. A.; Thorbjornsen, A. R.

1967-01-01

Digital computer programs determine steady-state performance characteristics of active and passive linear circuits. The ac analysis program solves the basic circuit parameters. The compiler program solves these circuit parameters and in addition provides a more versatile program by allowing the user to perform mathematical and logical operations.

Newton's method applied to finite-difference approximations for the steady-state compressible Navier-Stokes equations

NASA Technical Reports Server (NTRS)

Bailey, Harry E.; Beam, Richard M.

1991-01-01

Finite-difference approximations for steady-state compressible Navier-Stokes equations, whose two spatial dimensions are written in generalized curvilinear coordinates and strong conservation-law form, are presently solved by means of Newton's method in order to obtain a lifting-airfoil flow field under subsonic and transonnic conditions. In addition to ascertaining the computational requirements of an initial guess ensuring convergence and the degree of computational efficiency obtainable via the approximate Newton method's freezing of the Jacobian matrices, attention is given to the need for auxiliary methods assessing the temporal stability of steady-state solutions. It is demonstrated that nonunique solutions of the finite-difference equations are obtainable by Newton's method in conjunction with a continuation method.

Kinetics of motility-induced phase separation and swim pressure

NASA Astrophysics Data System (ADS)

Patch, Adam; Yllanes, David; Marchetti, M. Cristina

Active Brownian particles (ABPs) represent a minimal model of active matter consisting of self-propelled spheres with purely repulsive interactions and rotational noise. We correlate the time evolution of the mean pressure towards its steady state value with the kinetics of motility-induced phase separation. For parameter values corresponding to phase separated steady states, we identify two dynamical regimes. The pressure grows monotonically in time during the initial regime of rapid cluster formation, overshooting its steady state value and then quickly relaxing to it, and remains constant during the subsequent slower period of cluster coalescence and coarsening. The overshoot is a distinctive feature of active systems. NSF-DMR-1305184, NSF-DGE-1068780, ACI-1341006, FIS2015-65078-C02, BIFI-ZCAM.

Investigation of dynamic characteristics of a turbine-propeller engine

NASA Technical Reports Server (NTRS)

Oppenheimer, Frank L; Jacques, James R

1951-01-01

Time constants that characterize engine speed response of a turbine-propeller engine over the cruising speed range for various values of constant fuel flow and constant blade angle were obtained both from steady-state characteristics and from transient operation. Magnitude of speed response to changes in fuel flow and blade angle was investigated and is presented in the form of gain factors. Results indicate that at any given value of speed in the engine cruising speed range, time constants obtained both from steady-state characteristics and from transient operation agree satisfactorily for any given constant fuel flow, whereas time constants obtained from transient operation exceed time constants obtained from steady-state characteristics by approximately 14 percent for any given blade angle.

Structure and Dynamics of Fluid Planets

NASA Astrophysics Data System (ADS)

Houben, H.

2014-12-01

Attention to conservation laws gives a comprehensive picture of the structure and dynamics of gas giants: Atmospheric differential rotation is generated by tidal torques (dependent on tropospheric static stability) and is dragged into the interior by turbulent viscosity. The consequent heat dissipation generates baroclinicity and approximate thermal wind balance, not Taylor-Proudman conditions. Magnetic Lorentz forces have no effect on the zonal wind, but generate a meridional wind approximately parallel to field lines. Thus, magnetic field generation in the interior is dominated by the ω-effect (zonal field wound up by differential rotation), with the α-effect (meridional field generated by turbulence) severely limited by the β-effect (turbulence-enhanced resistivity). The meridional circulation quenches the ω-effect so that a steady state is reached and also limits the magnitude of the non-axisymmetric field under certain circumstances. The stability of the steady state requires further study. The magnetic field travels with the E X B drift, rather than the fluid velocity. Work by the fluid on the magnetic field balances work by the magnetic field on the fluid, so the global heat flux is little changed. In conducting regions the meridional density distribution (and gravity field) is most sensitive to the total pressure (gas + magnetic) and the ω-effect. In nonconducting regions, the gas pressure, centrifugal force, and differential rotation dominate. The differential rotation varies at least as fast as r³, so the gravitational signal is small compared to that for differential rotation on cylinders. The entropy minimum near the tropopause allows meteorology to be dominated by (relatively) long-lived, closed potential temperature surfaces, usually called spots, which conserve potential vorticity. All of the above must be taken into account to properly assimilate any available observational data to further specify the interior properties of fluid planets.

Toxicokinetic Triage for Environmental Chemicals

PubMed Central

Wambaugh, John F.; Wetmore, Barbara A.; Pearce, Robert; Strope, Cory; Goldsmith, Rocky; Sluka, James P.; Sedykh, Alexander; Tropsha, Alex; Bosgra, Sieto; Shah, Imran; Judson, Richard; Thomas, Russell S.; Woodrow Setzer, R.

2015-01-01

Toxicokinetic (TK) models link administered doses to plasma, blood, and tissue concentrations. High-throughput TK (HTTK) performs in vitro to in vivo extrapolation to predict TK from rapid in vitro measurements and chemical structure-based properties. A significant toxicological application of HTTK has been “reverse dosimetry,” in which bioactive concentrations from in vitro screening studies are converted into in vivo doses (mg/kg BW/day). These doses are predicted to produce steady-state plasma concentrations that are equivalent to in vitro bioactive concentrations. In this study, we evaluate the impact of the approximations and assumptions necessary for reverse dosimetry and develop methods to determine whether HTTK tools are appropriate or may lead to false conclusions for a particular chemical. Based on literature in vivo data for 87 chemicals, we identified specific properties (eg, in vitro HTTK data, physico-chemical descriptors, and predicted transporter affinities) that correlate with poor HTTK predictive ability. For 271 chemicals we developed a generic HT physiologically based TK (HTPBTK) model that predicts non-steady-state chemical concentration time-courses for a variety of exposure scenarios. We used this HTPBTK model to find that assumptions previously used for reverse dosimetry are usually appropriate, except most notably for highly bioaccumulative compounds. For the thousands of man-made chemicals in the environment that currently have no TK data, we propose a 4-element framework for chemical TK triage that can group chemicals into 7 different categories associated with varying levels of confidence in HTTK predictions. For 349 chemicals with literature HTTK data, we differentiated those chemicals for which HTTK approaches are likely to be sufficient, from those that may require additional data. PMID:26085347

Role of retinal slip in the prediction of target motion during smooth and saccadic pursuit.

PubMed

de Brouwer, S; Missal, M; Lefèvre, P

2001-08-01

Visual tracking of moving targets requires the combination of smooth pursuit eye movements with catch-up saccades. In primates, catch-up saccades usually take place only during pursuit initiation because pursuit gain is close to unity. This contrasts with the lower and more variable gain of smooth pursuit in cats, where smooth eye movements are intermingled with catch-up saccades during steady-state pursuit. In this paper, we studied in detail the role of retinal slip in the prediction of target motion during smooth and saccadic pursuit in the cat. We found that the typical pattern of pursuit in the cat was a combination of smooth eye movements with saccades. During smooth pursuit initiation, there was a correlation between peak eye acceleration and target velocity. During pursuit maintenance, eye velocity oscillated at approximately 3 Hz around a steady-state value. The average gain of smooth pursuit was approximately 0.5. Trained cats were able to continue pursuing in the absence of a visible target, suggesting a role of the prediction of future target motion in this species. The analysis of catch-up saccades showed that the smooth-pursuit motor command is added to the saccadic command during catch-up saccades and that both position error and retinal slip are taken into account in their programming. The influence of retinal slip on catch-up saccades showed that prediction about future target motion is used in the programming of catch-up saccades. Altogether, these results suggest that pursuit systems in primates and cats are qualitatively similar, with a lower average gain in the cat and that prediction affects both saccades and smooth eye movements during pursuit.

Alternative refrigerants and refrigeration cycles for domestic refrigerators

DOE Office of Scientific and Technical Information (OSTI.GOV)

Sand, J.R.; Rice, C.L.; Vineyard, E.A.

1992-12-01

This project initially focused on using nonazeotropic refrigerant mixtures (NARMs) in a two-evaporator refrigerator-freezer design using two stages of liquid refrigerant subcooling. This concept was proposed and tested in 1975. The work suggested that the concept was 20% more efficient than the conventional one-evaporator refrigerator-freezer (RF) design. After considerable planning and system modeling based on using a NARM in a Lorenz-Meutzner (L-M) RF, the program scope was broadened to include investigation of a ``dual-loop`` concept where energy savings result from exploiting the less stringent operating conditions needed to satisfy cooling, of the fresh food section. A steady-state computer model (CYCLE-Z)more » capable of simulating conventional, dual loop, and L-M refrigeration cycles was developed. This model was used to rank the performance of 20 ozone-safe NARMs in the L-M refrigeration cycle while key system parameters were systematically varied. The results indicated that the steady-state efficiency of the L-M design was up to 25% greater than that of a conventional cycle. This model was also used to calculate the performance of other pure refrigerants relative to that of dichlorodifluoromethane, R-12, in conventional and dual-loop RF designs. Projected efficiency gains for these cycles were more modest, ranging from 0 to 10%. Individual compressor calorimeter tests of nine combinations of evaporator and condenser temperatures usually used to map RF compressor performance were carried out with R-12 and two candidate L-M NARMs in several compressors. Several models of a commercially produced two-evaporator RF were obtained as test units. Two dual-loop RF designs were built and tested as part of this project.« less

An equation-free probabilistic steady-state approximation: dynamic application to the stochastic simulation of biochemical reaction networks.

PubMed

Salis, Howard; Kaznessis, Yiannis N

2005-12-01

Stochastic chemical kinetics more accurately describes the dynamics of "small" chemical systems, such as biological cells. Many real systems contain dynamical stiffness, which causes the exact stochastic simulation algorithm or other kinetic Monte Carlo methods to spend the majority of their time executing frequently occurring reaction events. Previous methods have successfully applied a type of probabilistic steady-state approximation by deriving an evolution equation, such as the chemical master equation, for the relaxed fast dynamics and using the solution of that equation to determine the slow dynamics. However, because the solution of the chemical master equation is limited to small, carefully selected, or linear reaction networks, an alternate equation-free method would be highly useful. We present a probabilistic steady-state approximation that separates the time scales of an arbitrary reaction network, detects the convergence of a marginal distribution to a quasi-steady-state, directly samples the underlying distribution, and uses those samples to accurately predict the state of the system, including the effects of the slow dynamics, at future times. The numerical method produces an accurate solution of both the fast and slow reaction dynamics while, for stiff systems, reducing the computational time by orders of magnitude. The developed theory makes no approximations on the shape or form of the underlying steady-state distribution and only assumes that it is ergodic. We demonstrate the accuracy and efficiency of the method using multiple interesting examples, including a highly nonlinear protein-protein interaction network. The developed theory may be applied to any type of kinetic Monte Carlo simulation to more efficiently simulate dynamically stiff systems, including existing exact, approximate, or hybrid stochastic simulation techniques.

Synthesis and Turnover of Embryonic Sea Urchin Ciliary Proteins during Selective Inhibition of Tubulin Synthesis and Assembly

PubMed Central

Stephens, Raymond E.

1997-01-01

When ciliogenesis first occurs in sea urchin embryos, the major building block proteins, tubulin and dynein, exist in substantial pools, but most 9+2 architectural proteins must be synthesized de novo. Pulse-chase labeling with [3H]leucine demonstrates that these proteins are coordinately up-regulated in response to deciliation so that regeneration ensues and the tubulin and dynein pools are replenished. Protein labeling and incorporation into already-assembled cilia is high, indicating constitutive ciliary gene expression and steady-state turnover. To determine whether either the synthesis of tubulin or the size of its available pool is coupled to the synthesis or turnover of the other 9+2 proteins in some feedback manner, fully-ciliated mid- or late-gastrula stage Strongylocentrotus droebachiensis embryos were pulse labeled in the presence of colchicine or taxol at concentrations that block ciliary growth. As a consequence of tubulin autoregulation mediated by increased free tubulin, no labeling of ciliary tubulin occurred in colchicine-treated embryos. However, most other proteins were labeled and incorporated into steady-state cilia at near-control levels in the presence of colchicine or taxol. With taxol, tubulin was labeled as well. An axoneme-associated 78 kDa cognate of the molecular chaperone HSP70 correlated with length during regeneration; neither colchicine nor taxol influenced the association of this protein in steady-state cilia. These data indicate that 1) ciliary protein synthesis and turnover is independent of tubulin synthesis or tubulin pool size; 2) steady-state incorporation of labeled proteins cannot be due to formation or elongation of cilia; 3) substantial tubulin exchange takes place in fully-motile cilia; and 4) chaperone presence and association in steady-state cilia is independent of background ciliogenesis, tubulin synthesis, and tubulin assembly state. PMID:9362062

Integration of plume and puff diffusion models/application of CFD

NASA Astrophysics Data System (ADS)

Mori, Akira

The clinical symptoms of patients and other evidences of a gas poisoning accident inside an industrial building strongly suggested an abrupt influx of engine exhaust from a construction vehicle which was operating outside in the open air. But the obviously high level of gas concentration could not be well explained by any conventional steady-state gas diffusion models. The author used an unsteady-state continuous Puff Model to simulate the time-wise changes in air stream with the pollutant gas being continuously emitted, and successfully reproduced the observed phenomena. The author demonstrates that this diffusion formula can be solved analytically by the use of error function as long as the change in wind velocity is stepwise, and clarifies the accurate differences between the unsteady- and steady-states and their convergence profiles. Also, the relationship between the Puff and Plume Models is discussed. The case study included a computational fluid dynamics (CFD) analysis to estimate the steady-state air stream and the gas concentration pattern in the affected area. It is well known that clear definition of the boundary conditions is key to successful CFD analysis. The author describes a two-step use of CFD: the first step to define the boundary conditions and the second to determine the steady-state air stream and the gas concentration pattern.

Cyclic steady state stress-strain behavior of UHMW polyethylene.

PubMed

Krzypow, D J; Rimnac, C M

2000-10-01

To increase the long-term performance of total joint replacements, finite element analyses of ultra high molecular weight polyethylene (UHMWPE) components have been conducted to predict the effect of load on the stress and strain distributions occurring on and within these components. Early models incorporated the monotonic behavior of UHMWPE without considering the unloading and cyclic loading behavior. However, UHMWPE components undergo cyclic loading during use and at least two wear damage modes (pitting and delamination) are thought to be associated with the fatigue fracture properties of UHMWPE. The objective of this study was to examine the fully reversed uniaxial tension/compression cyclic steady state stress-strain behavior of UHMWPE as a first step towards developing a cyclic constitutive relationship for UHMWPE. The hypothesis that cycling results in a permanent change in the stress-strain relationship, that is, that the cyclic steady state represents a new cyclically stabilized state, was examined. It was found that, like other ductile polymers, UHMWPE substantially cyclically softens under fully reversed uniaxial straining. More cyclic softening occurred in tension than in compression. Furthermore, cyclic steady state was attained, but not cyclic stability. It is suggested that it may be more appropriate to base a material constitutive relationship for UHMWPE for finite element analyses of components upon a cyclically modified stress-strain relationship.

Fast cooling for a system of stochastic oscillators

DOE Office of Scientific and Technical Information (OSTI.GOV)

Chen, Yongxin, E-mail: chen2468@umn.edu; Georgiou, Tryphon T., E-mail: tryphon@umn.edu; Pavon, Michele, E-mail: pavon@math.unipd.it

2015-11-15

We study feedback control of coupled nonlinear stochastic oscillators in a force field. We first consider the problem of asymptotically driving the system to a desired steady state corresponding to reduced thermal noise. Among the feedback controls achieving the desired asymptotic transfer, we find that the most efficient one from an energy point of view is characterized by time-reversibility. We also extend the theory of Schrödinger bridges to this model, thereby steering the system in finite time and with minimum effort to a target steady-state distribution. The system can then be maintained in this state through the optimal steady-state feedbackmore » control. The solution, in the finite-horizon case, involves a space-time harmonic function φ, and −logφ plays the role of an artificial, time-varying potential in which the desired evolution occurs. This framework appears extremely general and flexible and can be viewed as a considerable generalization of existing active control strategies such as macromolecular cooling. In the case of a quadratic potential, the results assume a form particularly attractive from the algorithmic viewpoint as the optimal control can be computed via deterministic matricial differential equations. An example involving inertial particles illustrates both transient and steady state optimal feedback control.« less

Non-equilibrium steady states in the Klein-Gordon theory

NASA Astrophysics Data System (ADS)

Doyon, Benjamin; Lucas, Andrew; Schalm, Koenraad; Bhaseen, M. J.

2015-03-01

We construct non-equilibrium steady states in the Klein-Gordon theory in arbitrary space dimension d following a local quench. We consider the approach where two independently thermalized semi-infinite systems, with temperatures {{T}L} and {{T}R}, are connected along a d-1-dimensional hypersurface. A current-carrying steady state, described by thermally distributed modes with temperatures {{T}L} and {{T}R} for left and right-moving modes, respectively, emerges at late times. The non-equilibrium density matrix is the exponential of a non-local conserved charge. We obtain exact results for the average energy current and the complete distribution of energy current fluctuations. The latter shows that the long-time energy transfer can be described by a continuum of independent Poisson processes, for which we provide the exact weights. We further describe the full time evolution of local observables following the quench. Averages of generic local observables, including the stress-energy tensor, approach the steady state with a power-law in time, where the exponent depends on the initial conditions at the connection hypersurface. We describe boundary conditions and special operators for which the steady state is reached instantaneously on the connection hypersurface. A semiclassical analysis of freely propagating modes yields the average energy current at large distances and late times. We conclude by comparing and contrasting our findings with results for interacting theories and provide an estimate for the timescale governing the crossover to hydrodynamics. As a modification of our Klein-Gordon analysis we also include exact results for free Dirac fermions.

Analytical solutions of one-dimensional multispecies reactive transport in a permeable reactive barrier-aquifer system

NASA Astrophysics Data System (ADS)

Mieles, John; Zhan, Hongbin

2012-06-01

The permeable reactive barrier (PRB) remediation technology has proven to be more cost-effective than conventional pump-and-treat systems, and has demonstrated the ability to rapidly reduce the concentrations of specific chemicals of concern (COCs) by up to several orders of magnitude in some scenarios. This study derives new steady-state analytical solutions to multispecies reactive transport in a PRB-aquifer (dual domain) system. The advantage of the dual domain model is that it can account for the potential existence of natural degradation in the aquifer, when designing the required PRB thickness. The study focuses primarily on the steady-state analytical solutions of the tetrachloroethene (PCE) serial degradation pathway and secondly on the analytical solutions of the parallel degradation pathway. The solutions in this study can also be applied to other types of dual domain systems with distinct flow and transport properties. The steady-state analytical solutions are shown to be accurate and the numerical program RT3D is selected for comparison. The results of this study are novel in that the solutions provide improved modeling flexibility including: 1) every species can have unique first-order reaction rates and unique retardation factors, and 2) daughter species can be modeled with their individual input concentrations or solely as byproducts of the parent species. The steady-state analytical solutions exhibit a limitation that occurs when interspecies reaction rate factors equal each other, which result in undefined solutions. Excel spreadsheet programs were created to facilitate prompt application of the steady-state analytical solutions, for both the serial and parallel degradation pathways.