S4. ASYMMETRIC DRUG-INDUCED PARKINSONISM IS RELATED TO PSYCHOPATHOLOGY

PubMed Central

Pieters, Lydia; Bakker, P Roberto; Van Harten, Peter N

2018-01-01

severity index (CGI-SCH SI). Discussion DIP is asymmetric in 1 of 5 patients. Therefore, the clinical rule that Parkinson’s disease always starts asymmetrically and such may be helpful to differentiate between Parkinson’s disease and DIP is not valid. Asymmetric presentation of DIP is of clinical relevance as it is related to the severity of psychopathology. Asymmetric DIP may alert the clinician of more severe psychopathology. Replication is indicated to examine the robustness of the relationship. References 1. Modestin J, Wehrli MV, Stephan PL, Agarwalla P. Evolution of neuroleptic-induced extrapyramidal syndromes under long-term neuroleptic treatment. Schizophr Res. 2008; 100(1–3): 97–107. 2. Janno S, Holi M, Tuisku K, Wahlbeck K. Prevalence of Neuroleptic-Induced Movement Disorders in Chronic Schizophrenia Inpatients. Am J Psychiatry. 2004; 161(1): 160–163. 3. Harten PN Van, Matroos GE, Hoek HW. The prevalence of tardive dystonia, tardive dyskinesia, parkinsonism and akathisia. The Curaçao Extrapyramidal Syndromes Study I. Schizophr Res. 1996; 19(2): 195–203. 4. Shin H, Chung J. Drug-Induced Parkinsonism. J Clin Neurol. 2012; 8: 15–21. 5. Bakker PR, de Groot IW, van Os J, van Harten PN. Long-Stay Psychiatric Patients: A Prospective Study Revealing Persistent Antipsychotic-Induced Movement Disorder. PLoS One. 2011; 6(10): 1–6.