Sample records for valgusime snnib lae

  1. [Overexpression of LaeA enhances mevastatin production and reduces sporulation of Penicillium citrinum].

    PubMed

    Zheng, Yueliang; Cao, Shuang; Huang, Yuqi; Liao, Guojian; Hu, Changhua

    2014-12-04

    To study the regulation of laeA overexpression on mevastatin production and sporulation in Penicillium citrinum. We cloned the laeA gene from Penicillium citrinum and constructed the vector pGiHTGi-laeA. The plasmid pGiHTGi-laeA was transformed in Penicillium citrinum by agrobacterium tumefaciens-mediated transformation. Positive transformants were detected by cloning the hygromycin gene. The mevastatin production of the wild type and OE:: laeA was compared by HPLC. The conidia number was counted by blood counting chamber. The biosynthetic gene cluster expression quantity of mevastatin in the wild type and OE: :laeA were analyzed by qRT-PCR. We constructed the plasmid pGiHTGi-laeA, and screened the positive transformants that overexpress the laeA in Penicillium citrinum. With the overexpression of laeA, the mevastatin production was increased from (0.69 ± 0.12) mg/g to (4.02 ± 0.50) mg/g dry cell weight. Compared to the wild type strain, the laeA expression quantity in the OE :: laeA strain increased 29%, and the mlcB expression increased 72%, the mlcR expression increased 153%. Moreover, the overexpression of laeA would decrease the conidia number. Overexpression of LaeA enhances mevastatin production and reduces sporulation of Penicillium citrinum, with increases expression of pathway-regulator mlcR, and biosynthetic gene MlcR. These results could guide global regulatory mechanism of mevastatin biosynthesis and the exploitation of high-production strain.

  2. The putative protein methyltransferase LAE1 controls cellulase gene expression in Trichoderma reesei

    PubMed Central

    Seiboth, Bernhard; Karimi, Razieh Aghcheh; Phatale, Pallavi A; Linke, Rita; Hartl, Lukas; Sauer, Dominik G; Smith, Kristina M; Baker, Scott E; Freitag, Michael; Kubicek, Christian P

    2012-01-01

    Summary Trichoderma reesei is an industrial producer of enzymes that degrade lignocellulosic polysaccharides to soluble monomers, which can be fermented to biofuels. Here we show that the expression of genes for lignocellulose degradation are controlled by the orthologous T. reesei protein methyltransferase LAE1. In a lae1 deletion mutant we observed a complete loss of expression of all seven cellulases, auxiliary factors for cellulose degradation, β-glucosidases and xylanases were no longer expressed. Conversely, enhanced expression of lae1 resulted in significantly increased cellulase gene transcription. Lae1-modulated cellulase gene expression was dependent on the function of the general cellulase regulator XYR1, but also xyr1 expression was LAE1-dependent. LAE1 was also essential for conidiation of T. reesei. Chromatin immunoprecipitation followed by high-throughput sequencing (‘ChIP-seq’) showed that lae1 expression was not obviously correlated with H3K4 di- or trimethylation (indicative of active transcription) or H3K9 trimethylation (typical for heterochromatin regions) in CAZyme coding regions, suggesting that LAE1 does not affect CAZyme gene expression by directly modulating H3K4 or H3K9 methylation. Our data demonstrate that the putative protein methyltransferase LAE1 is essential for cellulase gene expression in T. reesei through mechanisms that remain to be identified. PMID:22554051

  3. Foreground mitigation strategy for measuring the 21 cm-LAE cross-correlation

    NASA Astrophysics Data System (ADS)

    Yoshiura, Shintaro; Line, Jack L. B.; Kubota, Kenji; Hasegawa, Kenji; Takahashi, Keitaro

    2018-05-01

    The cross power spectrum of the 21 cm signal and Lyman-α emitters (LAEs) is a probe of the Epoch of Reionization. Astrophysical foregrounds do not correlate with the LAE distribution, though the foregrounds contribute to the error. To study the impact of foregrounds on the measurement, we assume realistic observation by the Murchison Widefield Array using a catalogue of radio galaxies, a LAE survey by the Subaru Hyper Supreme-Cam and the redshift of LAEs is determined by the Prime Focus Spectrograph. The HI distribution is estimated from a radiative transfer simulation with models based on results of radiation hydrodynamics simulation. Using these models, we found that the error of cross power spectrum is dominated by foreground terms. Furthermore, we estimate the effects of foreground removal, and find 99% of the foreground removal is required to detect the 21 cm-LAE signal at k ~ 0.4 h Mpc-1.

  4. The global regulator LaeA controls production of citric acid and endoglucanases in Aspergillus carbonarius.

    PubMed

    Linde, Tore; Zoglowek, Marta; Lübeck, Mette; Frisvad, Jens Christian; Lübeck, Peter Stephensen

    2016-08-01

    The global regulatory protein LaeA is known for regulating the production of many kinds of secondary metabolites in Aspergillus species, as well as sexual and asexual reproduction, and morphology. In Aspergillus carbonarius, it has been shown that LaeA regulates production of ochratoxin. We have investigated the regulatory effect of LaeA on production of citric acid and cellulolytic enzymes in A. carbonarius. Two types of A. carbonarius strains, having laeA knocked out or overexpressed, were constructed and tested in fermentation. The knockout of laeA significantly decreased the production of citric acid and endoglucanases, but did not reduce the production of beta-glucosidases or xylanases. The citric acid accumulation was reduced with 74-96 % compared to the wild type. The endoglucanase activity was reduced with 51-78 %. Overexpression of LaeA seemed not to have an effect on citric acid production or on cellulose or xylanase activity.

  5. The Putative Protein Methyltransferase LAE1 of Trichoderma atroviride Is a Key Regulator of Asexual Development and Mycoparasitism

    PubMed Central

    Aghcheh, Razieh Karimi; Druzhinina, Irina S.; Kubicek, Christian P.

    2013-01-01

    In Ascomycota the protein methyltransferase LaeA is a global regulator that affects the expression of secondary metabolite gene clusters, and controls sexual and asexual development. The common mycoparasitic fungus Trichoderma atroviride is one of the most widely studied agents of biological control of plant-pathogenic fungi that also serves as a model for the research on regulation of asexual sporulation (conidiation) by environmental stimuli such as light and/or mechanical injury. In order to learn the possible involvement of LAE1 in these two traits, we assessed the effect of deletion and overexpression of lae1 gene on conidiation and mycoparasitic interaction. In the presence of light, conidiation was 50% decreased in a Δ lae1 and 30–50% increased in lae1-overexpressing (OElae1) strains. In darkness, Δ lae1 strains did not sporulate, and the OElae1 strains produced as much spores as the parent strain. Loss-of-function of lae1 also abolished sporulation triggered by mechanical injury of the mycelia. Deletion of lae1 also increased the sensitivity of T. atroviride to oxidative stress, abolished its ability to defend against other fungi and led to a loss of mycoparasitic behaviour, whereas the OElae1 strains displayed enhanced mycoparasitic vigor. The loss of mycoparasitic activity in the Δ lae1 strain correlated with a significant underexpressionn of several genes normally upregulated during mycoparasitic interaction (proteases, GH16 ß-glucanases, polyketide synthases and small cystein-rich secreted proteins), which in turn was reflected in the partial reduction of formation of fungicidal water soluble metabolites and volatile compounds. Our study shows T. atroviride LAE1 is essential for asexual reproduction in the dark and for defense and parasitism on other fungi. PMID:23826217

  6. A simultaneous search for High-z LAEs and LBGs in the SHARDS survey

    NASA Astrophysics Data System (ADS)

    Haro, P. Arrabal; Espinosa, J. M. Rodríguez; Muñoz-Tuñón, C.; Pérez-González, P. G.; Dannerbauer, H.; Bongiovann, Á.; Barro, G.; Cava, A.; Lumbreras-Calle, A.; Hernán-Caballero, A.; Eliche-Moral, M. C.; Sánchez, H. Dománguez; Conselice, C. J.; Tresse, L.; Pampliega, B. Alcalde; Balcells, M.; Daddi, E.; Rodighiero, G.

    2018-05-01

    We have undertaken a comprehensive search for both Lyman Alpha Emitters (LAEs) and Lyman Break Galaxies (LBGs) in the SHARDS Survey of the GOODS-N field. SHARDS is a deep imaging survey, made with the 10.4 m Gran Telescopio Canarias (GTC), employing 25 medium band filters in the range from 500 to 941 nm. This is the first time that both LAEs and LBGs are surveyed simultaneously in a systematic way in a large field. We draw a sample of 1558 sources; 528 of them are LAEs. Most of the sources (1434) show rest-frame UV continua. A minority of them (124) are pure LAEs with virtually no continuum detected in SHARDS. We study these sources from z ˜ 3.35 up to z ˜ 6.8, well into the epoch of reionization. Note that surveys done with just one or two narrow band filters lack the possibility to spot the rest-frame UV continuum present in most of our LAEs. We derive redshifts, Star Formation Rates (SFRs), Lyα Equivalent Widths (EWs) and Luminosity Functions (LFs). Grouping within our sample is also studied, finding 92 pairs or groups of galaxies at the same redshift separated by less than 60 comoving kpc. In addition, we relate 87 and 55 UV-selected objects with two known overdensities at z = 4.05 and z = 5.198, respectively. Finally, we show that surveys made with broad band filters are prone to introduce many unwanted sources (˜20% interlopers), which means that previous studies may be overestimating the calculated LFs, specially at the faint end.

  7. Control of Propellant Lead/Lag to the LAE in the AXAF Propulsion System

    NASA Technical Reports Server (NTRS)

    Casillas, A. R.; Eninger, J.; Joseph, G.; Kenney, J.; Trinidad, M.

    1998-01-01

    Control of the rate at which hypergolic propellants are supplied to a rocket engine prior to ignition is critically important. Potentially damaging explosions may result from excessive lead of either propellant into the combustion chamber. Because the injector fill process is governed by the engine as well as the propellant feed system design, proper management of this issue must take both into consideration. This was recognized early in the development of TRW's Advanced Columbium-Liquid Apogee Engine (LAE), which was flight-qualified in 1996 to maneuver the Advanced X-Ray Astrophysics Facility (AXAF) spacecraft into orbit. The LAE runs on hydrazine and nitrogen tetroxide (MON-3) at a nominal mixture ratio of 1.0. This paper describes the comprehensive test program conducted to ensure reliable startup operation of the LAE in the AYAF propulsion system. The most significant factors affecting chamber fuel lead were found to be: (1) engine location, (2) propellant saturation level, (3) amount of undissolved gas in the lines, and (4) off- nominal tank pressures. Hot-fire tests at a chamber fuel lead range over and above that expected for the LAEs in AXAF demonstrated extremely tolerant behavior of the engine. AY-AF is scheduled for launch on NASA's STS-93 in December 1998.

  8. Fungus-Specific Sirtuin HstD Coordinates Secondary Metabolism and Development through Control of LaeA

    PubMed Central

    Kawauchi, Moriyuki; Nishiura, Mika

    2013-01-01

    The sirtuins are members of the NAD+-dependent histone deacetylase family that contribute to various cellular functions that affect aging, disease, and cancer development in metazoans. However, the physiological roles of the fungus-specific sirtuin family are still poorly understood. Here, we determined a novel function of the fungus-specific sirtuin HstD/Aspergillus oryzae Hst4 (AoHst4), which is a homolog of Hst4 in A. oryzae yeast. The deletion of all histone deacetylases in A. oryzae demonstrated that the fungus-specific sirtuin HstD/AoHst4 is required for the coordination of fungal development and secondary metabolite production. We also show that the expression of the laeA gene, which is the most studied fungus-specific coordinator for the regulation of secondary metabolism and fungal development, was induced in a ΔhstD strain. Genetic interaction analysis of hstD/Aohst4 and laeA clearly indicated that HstD/AoHst4 works upstream of LaeA to coordinate secondary metabolism and fungal development. The hstD/Aohst4 and laeA genes are fungus specific but conserved in the vast family of filamentous fungi. Thus, we conclude that the fungus-specific sirtuin HstD/AoHst4 coordinates fungal development and secondary metabolism via the regulation of LaeA in filamentous fungi. PMID:23729383

  9. Discovery of the Highest Redshift Protocluster: LAEs at z=6.5

    NASA Astrophysics Data System (ADS)

    Chanchaiworawit, Krittapas; Guzman, Rafael; ALBA

    2018-01-01

    We present the photometric candidates, spectroscopic confirmations, and clustering analysis from our search for one of the earliest protoclusters near the end of Cosmic Reionization Epoch. The observations are carried out using high-throughput optical-NIR imager and spectrograph OSIRIS at the 10.4m Gran Telescopio Canarias (GTC). The overdensity leading to the sign of protocluster is found around 2 massive Lyman Alpha Emitters (LAEs) at z=6.5 in SXDS-N field. The total GTC observing time in three medium band photometry (F883w35, F913w25 and F941w33) is over 34 hours covering 8x8 arcminute2 (~30,000 Mpc3 at z=6.5), resulting in identification of 45 fainter LAE candidates. The spectroscopic follow-up of 17 candidates are in the ongoing phase of observations (2016B and 2017B). However, the preliminary results show that at least 6 LAEs are confirmed by showing the signature of faint Lyman-α emission. The clustering analysis based on the overdense level derived from the photometric luminosity function also suggests that the protocluster will evolve to resemble the most massive galaxy clusters observable in the local Universe.

  10. Enhanced itaconic acid production in Aspergillus with increased LaeA expression

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Dai, Ziyu; Baker, Scott E.

    Fungi, such as Aspergillus niger, having a dolichyl-P-Man:Man(5)GlcNAc(2)-PP-dolichyl mannosyltransferase (Alg3) gene genetic inactivation, increased expression of a loss of aflR expression A (LaeA), or both, are described. In some examples, such mutants have several phenotypes, including an increased production of citric acid relative to the parental strain. Methods of using the disclosed fungi to make citric acid are also described, as are compositions and kits including the disclosed fungi. Further described are Aspergillus terreus fungi overexpressing the LaeA gene and the use of such fungi for the production of itaconic acid.

  11. Functional roles of FgLaeA in controlling secondary metabolism, sexual development, and virulence in Fusarium graminearum

    USDA-ARS?s Scientific Manuscript database

    Fusarium graminearum, the causal agent of Fusarium head blight in cereal crops, produces mycotoxins such as trichothecenes and zearalenone in infected plants. Here, we focused on the function of FgLaeA in F. graminearum, a homolog of Aspergillus nidulans LaeA encoding the global regulator for both s...

  12. The stellar mass, star formation rate and dark matter halo properties of LAEs at z ˜ 2

    NASA Astrophysics Data System (ADS)

    Kusakabe, Haruka; Shimasaku, Kazuhiro; Ouchi, Masami; Nakajima, Kimihiko; Goto, Ryosuke; Hashimoto, Takuya; Konno, Akira; Harikane, Yuichi; Silverman, John D.; Capak, Peter L.

    2018-01-01

    We present average stellar population properties and dark matter halo masses of z ˜ 2 Lyα emitters (LAEs) from spectral energy distribution fitting and clustering analysis, respectively, using ≃ 1250 objects (NB387≤25.5) in four separate fields of ≃ 1 deg2 in total. With an average stellar mass of 10.2 ± 1.8 × 108 M⊙ and star formation rate of 3.4 ± 0.4 M⊙ yr-1, the LAEs lie on an extrapolation of the star-formation main sequence (MS) to low stellar mass. Their effective dark matter halo mass is estimated to be 4.0_{-2.9}^{+5.1} × 10^{10}{ }M_{⊙} with an effective bias of 1.22^{+0.16}_{-0.18}, which is lower than that of z ˜ 2 LAEs (1.8 ± 0.3) obtained by a previous study based on a three times smaller survey area, with a probability of 96%. However, the difference in the bias values can be explained if cosmic variance is taken into account. If such a low halo mass implies a low H I gas mass, this result appears to be consistent with the observations of a high Lyα escape fraction. With the low halo masses and ongoing star formation, our LAEs have a relatively high stellar-to-halo mass ratio (SHMR) and a high efficiency of converting baryons into stars. The extended Press-Schechter formalism predicts that at z = 0 our LAEs are typically embedded in halos with masses similar to that of the Large Magellanic Cloud (LMC); they will also have similar SHMRs to the LMC, if their star formation rates are largely suppressed after z ˜ 2 as some previous studies have reported for the LMC itself.

  13. Shallow seismicity of arc-continent collision near Lae, Papua New Guinea

    NASA Astrophysics Data System (ADS)

    Kulig, Christopher; McCaffrey, Robert; Abers, Geoffrey A.; Letz, Horst

    1993-11-01

    In northeastern New Guinea, the narrow Ramu-Markham Valley (RMV) separates island arc rocks to the north from those of continental origin to the south and appears to be the western, onland extension of the New Britain trench. To explore the tectonic processes at the leading edge of the island arc during collision, we operated a portable seismic network for six weeks near the city of Lae at the eastern end of the RMV. We observed a narrow, near-vertical belt of seismicity between 10 and 30 km depth, that we call the Lae Seismic Zone (LSZ), starting at the RMV in the southwest and trending northeasterly cutting across surface geologic structure. The truncation of the LSZ along a steep plane by the Ramu-Markham Fault Zone (RMFZ) and earthquake first motions suggest that the earthquakes occur in the hanging wall of a steep, N-dipping fault that crops out at the RMFZ. We also consider that the LSZ is within the lower plate of a gently dipping thrust. Below 20 km depth the microearthquake zone is truncated by a gently, NE-dipping plane coinciding in depth and dip with nodal planes of recent large ( mb = 5.6 and 6.0) thrust earthquakes. We suggest that the Huon Peninsula is being emplaced onto the Australian plate along a gently (~ 25°) dipping thrust fault that is 20 km deep beneath Lae. The RMFZ may be a steeply dipping thrust fault that connects with this gently, N-dipping thrust but accommodates little convergence at present. The LSZ trends nearly perpendicular to an anticlinal range which appears to be sheared in a left-lateral sense. P-wave first motions for earthquakes in the LSZ with steep (70° to 90° dip) nodal planes that strike parallel to the LSZ suggest a component of south-side-up displacement also. Hence, the crustal block south of the LSZ may be rising relative to the Huon Peninsula and the rapid Quaternary uplift rates estimated for the Lae coastal region may be higher than the uplift rate of the Huon Peninsula as a whole. We suggest that the LSZ

  14. Analytical procedure for the determination of Ethyl Lauroyl Arginate (LAE) to assess the kinetics and specific migration from a new antimicrobial active food packaging.

    PubMed

    Pezo, Davinson; Navascués, Beatriz; Salafranca, Jesús; Nerín, Cristina

    2012-10-01

    Ethyl Lauroyl Arginate (LAE) is a cationic tensoactive compound, soluble in water, with a wide activity spectrum against moulds and bacteria. LAE has been incorporated as antimicrobial agent into packaging materials for food contact and these materials require to comply with the specific migration criteria. In this paper, one analytical procedure has been developed and optimized for the analysis of LAE in food simulants after the migrations tests. It consists of the formation of an ionic pair between LAE and the inorganic complex Co(SCN)(4)(2-) in aqueous solution, followed by a liquid-liquid extraction in a suitable organic solvent and further UV-Vis absorbance measurement. In order to evaluate possible interferences, the ionic pair has been also analyzed by high performance liquid chromatography with UV-Vis detection. Both procedures provided similar analytical characteristics, with linear ranges from 1.10 to 25.00 mg kg(-1), linearity higher than 0.9886, limits of detection and quantification of 0.33 and 1.10 mg kg(-1), respectively, accuracy better than 1% as relative error and precision better than 3.6% expressed as RSD. Optimization of analytical techniques, thermal and chemical stability of LAE, as well as migration kinetics of LAE from experimental active packaging are reported and discussed. Copyright © 2012 Elsevier B.V. All rights reserved.

  15. Key role of LaeA and velvet complex proteins on expression of β-lactam and PR-toxin genes in Penicillium chrysogenum: cross-talk regulation of secondary metabolite pathways.

    PubMed

    Martín, Juan F

    2017-05-01

    Penicillium chrysogenum is an excellent model fungus to study the molecular mechanisms of control of expression of secondary metabolite genes. A key global regulator of the biosynthesis of secondary metabolites is the LaeA protein that interacts with other components of the velvet complex (VelA, VelB, VelC, VosA). These components interact with LaeA and regulate expression of penicillin and PR-toxin biosynthetic genes in P. chrysogenum. Both LaeA and VelA are positive regulators of the penicillin and PR-toxin biosynthesis, whereas VelB acts as antagonist of the effect of LaeA and VelA. Silencing or deletion of the laeA gene has a strong negative effect on penicillin biosynthesis and overexpression of laeA increases penicillin production. Expression of the laeA gene is enhanced by the P. chrysogenum autoinducers 1,3 diaminopropane and spermidine. The PR-toxin gene cluster is very poorly expressed in P. chrysogenum under penicillin-production conditions (i.e. it is a near-silent gene cluster). Interestingly, the downregulation of expression of the PR-toxin gene cluster in the high producing strain P. chrysogenum DS17690 was associated with mutations in both the laeA and velA genes. Analysis of the laeA and velA encoding genes in this high penicillin producing strain revealed that both laeA and velA acquired important mutations during the strain improvement programs thus altering the ratio of different secondary metabolites (e.g. pigments, PR-toxin) synthesized in the high penicillin producing mutants when compared to the parental wild type strain. Cross-talk of different secondary metabolite pathways has also been found in various Penicillium spp.: P. chrysogenum mutants lacking the penicillin gene cluster produce increasing amounts of PR-toxin, and mutants of P. roqueforti silenced in the PR-toxin genes produce large amounts of mycophenolic acid. The LaeA-velvet complex mediated regulation and the pathway cross-talk phenomenon has great relevance for improving the

  16. ChLae1 and ChVel1 Regulate T-toxin Production, Virulence, Oxidative Stress Response, and Development of the Maize Pathogen Cochliobolus heterostrophus

    PubMed Central

    Wu, Dongliang; Oide, Shinichi; Zhang, Ning; Choi, May Yee; Turgeon, B. Gillian

    2012-01-01

    LaeA and VeA coordinate secondary metabolism and differentiation in response to light signals in Aspergillus spp. Their orthologs, ChLae1 and ChVel1, were identified in the maize pathogen Cochliobolus heterostrophus, known to produce a wealth of secondary metabolites, including the host selective toxin, T-toxin. Produced by race T, T-toxin promotes high virulence to maize carrying Texas male sterile cytoplasm (T-cms). T-toxin production is significantly increased in the dark in wild type (WT), whereas Chvel1 and Chlae1 mutant toxin levels are much reduced in the dark compared to WT. Correspondingly, expression of T-toxin biosynthetic genes (Tox1) is up-regulated in the dark in WT, while dark-induced expression is much reduced/minimal in Chvel1 and Chlae1 mutants. Toxin production and Tox1 gene expression are increased in ChVEL1 overexpression (OE) strains grown in the dark and in ChLAE1 strains grown in either light or dark, compared to WT. These observations establish ChLae1 and ChVel1 as the first factors known to regulate host selective toxin production. Virulence of Chlae1 and Chvel1 mutants and OE strains is altered on both T-cms and normal cytoplasm maize, indicating that both T-toxin mediated super virulence and basic pathogenic ability are affected. Deletion of ChLAE1 or ChVEL1 reduces tolerance to H2O2. Expression of CAT3, one of the three catalase genes, is reduced in the Chvel1 mutant. Chlae1 and Chvel1 mutants also show decreased aerial hyphal growth, increased asexual sporulation and female sterility. ChLAE1 OE strains are female sterile, while ChVEL1 OE strains are more fertile than WT. ChLae1 and ChVel1 repress expression of 1,8-dihydroxynaphthalene (DHN) melanin biosynthesis genes, and, accordingly, melanization is enhanced in Chlae1 and Chvel1 mutants, and reduced in OE strains. Thus, ChLae1 and ChVel1 positively regulate T-toxin biosynthesis, pathogenicity and super virulence, oxidative stress responses, sexual development, and aerial hyphal

  17. LaeA and VeA are involved in growth morphology, asexual development, and mycotoxin production in Alternaria alternata.

    PubMed

    Estiarte, N; Lawrence, C B; Sanchis, V; Ramos, A J; Crespo-Sempere, A

    2016-12-05

    Alternaria alternata is a common filamentous fungus that contaminates various fruits, grains and vegetables causing important economic losses to farmers and the food industry. A. alternata is a mycotoxigenic mould, which may jeopardize human and animal health. Two of the most common A. alternata mycotoxins found in food and feed are alternariol and alternariol monomethyl ether. In this study we examined the role of LaeA and VeA, two regulatory proteins belonging to the velvet family, which have been described to be involved in several functions in many fungi including secondary metabolism. We found that deletion of laeA and veA genes, respectively, greatly reduced sporulation and strongly compromised mycotoxin production, both in vitro or during pathogenesis of tomato fruits. We have also studied how the loss of laeA and veA may affect expression of genes related to alternariol and alternariol monomethyl ether biosynthesis (pksJ and altR), and to melanin biosynthesis (cmrA, pksA). Copyright © 2016 Elsevier B.V. All rights reserved.

  18. VizieR Online Data Catalog: Photometry of LBGs, LAEs and GNBs at z~2.85 (Mostardi+, 2013)

    NASA Astrophysics Data System (ADS)

    Mostardi, R. E.; Shapley, A. E.; Nestor, D. B.; Steidel, C. C.; Reddy, N. A.; Trainor, R. F.

    2017-11-01

    We performed multi-object spectroscopy in 2011 May on the Keck 1 telescope, using the blue side of LRIS. We observed four slitmasks with exposure times of 16560, 9000, 8400, and 8100 s, respectively. For all masks, we used the 400 line/mm grism blazed at 3400 Å, achieving a spectral resolution of R=800 for 1.2" slits. The "d500" dichroic beam splitter was used for the first mask (originally designed for deep LyC spectroscopy) and the "d560" dichroic was used for the three additional masks (designed to acquire redshifts). The conditions during the observing run were suboptimal, with intermittent clouds and a seeing FWHM of 0.7"-1.0" during clear spells. When designing the slitmasks, we targeted both LBGs and LAEs with NB3420 detections. Slits were centered on the coordinates of the V (NB4670) centroid for LBGs (LAEs). While most LAEs were selected using the V-band image as the continuum band, a small fraction (20%) were selected using the G-band (henceforth referred to as GNBs). Overall, we observed 46 objects on the four slitmasks, 29 of which had repeat observations. (4 data files).

  19. Low Altitude Emission (LAE) of Energetic Neutral Atoms (ENA) Observed by TWINS and its Relation to the CINEMA CubeSat Mission

    NASA Astrophysics Data System (ADS)

    Bazell, D.; Sotirelis, T.; Nair, H.; Roelof, E. C.; Brandt, P. C.

    2009-12-01

    The brightest source of energetic neutral atoms (ENAs) at energies >1keV is low altitude emission (LAE) from ~200-400km near auroral latitudes where precipitating energetic ions undergo multiple atomic collisions with the monatomic (O) exosphere. This emission is many times brighter than that from the high-altitude ring current region where the energetic ions interact only weakly with the much less dense monatomic (H) hydrogen geocorona. The recently selected NSF CubeSat mission CINEMA [Lin et al., this special session] has, as part of its science payload (STEIN), an ENA imager covering energies 4-100keV. From a high-inclination ~800km orbit, STEIN will view the LAE four times during every 90 minutes. The NASA TWINS stereo ENA imagers (2-40keV) will also view the LAE from their Molniya orbits (apogee radius~7Re). We have been analyzing the TWINS ENA images of LAE and comparing them with in situ ion measurements (1-40keV) from DMSP spacecraft when their tracks take them under the ion precipitation regions imaged by TWINS. We have developed an ENA emissivity function that relates the directionally-dependent emergent ENA spectrum to that of the precipitating ions. The TWINS/DMSP direct comparisons show good agreement. We offer suggestions on joint observing strategies for CINEMA, TWINS and DMSP after the CINEMA launch in the second half of 2011.

  20. Identification of a classical mutant in the industrial host Aspergillus niger by systems genetics: LaeA is required for citric acid production and regulates the formation of some secondary metabolites

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Liu, Jing; Arentshorst, Mark; Nair, Deepa

    Rapid acidification of the culture medium by the production of organic acids and the production of acid-induced proteases are key characteristics of the filamentous fungus Aspergillus niger. The D15 mutant of A. niger is non-acidifying mutant and used often for the expression of recombinant proteins in A. niger, because of its reduced production of extracellular proteases under non-acidic conditions. In this study, the D15 mutant is characterized in detail. Strongly reduced levels of citric and oxalic acid were observed in the D15 mutant both in shake flask cultures and in controlled batch cultivations. To identify the mutation in the D15more » mutant, we successfully combined high-throughput sequencing (Illumina) with bulk segregant analysis. Because of the lack of a sexual cycle for A. niger, the parasexual cycle was used to generate a pool of segregants. From the 52 single nucleotide polymorphisms (SNPs) between the parental strains, three SNPs were homozygous in the genomic DNA of pool of segregants. These three SNPs mapped to all the right arm of chromosome II, indicating that this region contains the genetic locus affecting the phenotype related to acid production. Of the three SNPs, one mutation resulted in a missense mutation in the gene encoding the A. niger homologue of the A. nidulans methyltransferase gene laeA. Complementation analysis of the original mutant with the laeA gene and targeted disruption of laeA further confirmed that LaeA is involved in citric acid production in A. niger lab (N402) and citric acid production strains (ATCC 11414). Analysis of the secondary metabolite (SM) profile of the laeA mutants indicate that LaeA is required for the production of several SMs (asperrubrol, atromentin and JBIR86), but deletion of laeA also resulted in the presence of SMs (aspernigrin A/B and BMS-192548) that were not detected in the wild-type strain. The levels of ten other SMs were not strongly affected as a result of laeA deletion indicating that

  1. Systematic Identification of LAEs for Visible Exploration and Reionization Research Using Subaru HSC (SILVERRUSH). I. Program strategy and clustering properties of ˜2000 Lyα emitters at z = 6-7 over the 0.3-0.5 Gpc2 survey area

    NASA Astrophysics Data System (ADS)

    Ouchi, Masami; Harikane, Yuichi; Shibuya, Takatoshi; Shimasaku, Kazuhiro; Taniguchi, Yoshiaki; Konno, Akira; Kobayashi, Masakazu; Kajisawa, Masaru; Nagao, Tohru; Ono, Yoshiaki; Inoue, Akio K.; Umemura, Masayuki; Mori, Masao; Hasegawa, Kenji; Higuchi, Ryo; Komiyama, Yutaka; Matsuda, Yuichi; Nakajima, Kimihiko; Saito, Tomoki; Wang, Shiang-Yu

    2018-01-01

    We present the SILVERRUSH program strategy and clustering properties investigated with ˜2000 Lyα emitters (LAEs) at z = 5.7 and 6.6 found in the early data of the Hyper Suprime-Cam (HSC) Subaru Strategic Program survey exploiting the carefully designed narrow-band filters. We derive angular correlation functions with the unprecedentedly large samples of LAEs at z = 6-7 over the large total area of 14-21 deg2 corresponding to 0.3-0.5 comoving Gpc2. We obtain the average large-scale bias values of bavg = 4.1 ± 0.2 (4.5 ± 0.6) at z = 5.7 (z = 6.6) for ≳ L* LAEs, indicating a weak evolution of LAE clustering from z = 5.7 to 6.6. We compare the LAE clustering results with two independent theoretical models that suggest an increase of an LAE clustering signal by the patchy ionized bubbles at the epoch of reionization (EoR), and estimate the neutral hydrogen fraction to be x_{H I}=0.15^{+0.15}_{-0.15} at z = 6.6. Based on the halo occupation distribution models, we find that the ≳ L* LAEs are hosted by dark-matter halos with an average mass of log (< M_h > /M_⊙ ) =11.1^{+0.2}_{-0.4} (10.8^{+0.3}_{-0.5}) at z = 5.7 (6.6) with a Lyα duty cycle of 1% or less, where the results of z = 6.6 LAEs may be slightly biased, due to the increase of the clustering signal at the EoR. Our clustering analysis reveals the low-mass nature of ≳ L* LAEs at z = 6-7, and that these LAEs probably evolve into massive super-L* galaxies in the present-day universe.

  2. Identification of a Classical Mutant in the Industrial Host Aspergillus niger by Systems Genetics: LaeA Is Required for Citric Acid Production and Regulates the Formation of Some Secondary Metabolites

    PubMed Central

    Niu, Jing; Arentshorst, Mark; Nair, P. Deepa S.; Dai, Ziyu; Baker, Scott E.; Frisvad, Jens C.; Nielsen, Kristian F.; Punt, Peter J.; Ram, Arthur F.J.

    2015-01-01

    The asexual filamentous fungus Aspergillus niger is an important industrial cell factory for citric acid production. In this study, we genetically characterized a UV-generated A. niger mutant that was originally isolated as a nonacidifying mutant, which is a desirable trait for industrial enzyme production. Physiological analysis showed that this mutant did not secrete large amounts of citric acid and oxalic acid, thus explaining the nonacidifying phenotype. As traditional complementation approaches to characterize the mutant genotype were unsuccessful, we used bulk segregant analysis in combination with high-throughput genome sequencing to identify the mutation responsible for the nonacidifying phenotype. Since A. niger has no sexual cycle, parasexual genetics was used to generate haploid segregants derived from diploids by loss of whole chromosomes. We found that the nonacidifying phenotype was caused by a point mutation in the laeA gene. LaeA encodes a putative methyltransferase-domain protein, which we show here to be required for citric acid production in an A. niger lab strain (N402) and in other citric acid production strains. The unexpected link between LaeA and citric acid production could provide new insights into the transcriptional control mechanisms related to citric acid production in A. niger. Interestingly, the secondary metabolite profile of a ΔlaeA strain differed from the wild-type strain, showing both decreased and increased metabolite levels, indicating that LaeA is also involved in regulating the production of secondary metabolites. Finally, we show that our systems genetics approach is a powerful tool to identify trait mutations. PMID:26566947

  3. Identification of a Classical Mutant in the Industrial Host Aspergillus niger by Systems Genetics: LaeA Is Required for Citric Acid Production and Regulates the Formation of Some Secondary Metabolites.

    PubMed

    Niu, Jing; Arentshorst, Mark; Nair, P Deepa S; Dai, Ziyu; Baker, Scott E; Frisvad, Jens C; Nielsen, Kristian F; Punt, Peter J; Ram, Arthur F J

    2015-11-13

    The asexual filamentous fungus Aspergillus niger is an important industrial cell factory for citric acid production. In this study, we genetically characterized a UV-generated A. niger mutant that was originally isolated as a nonacidifying mutant, which is a desirable trait for industrial enzyme production. Physiological analysis showed that this mutant did not secrete large amounts of citric acid and oxalic acid, thus explaining the nonacidifying phenotype. As traditional complementation approaches to characterize the mutant genotype were unsuccessful, we used bulk segregant analysis in combination with high-throughput genome sequencing to identify the mutation responsible for the nonacidifying phenotype. Since A. niger has no sexual cycle, parasexual genetics was used to generate haploid segregants derived from diploids by loss of whole chromosomes. We found that the nonacidifying phenotype was caused by a point mutation in the laeA gene. LaeA encodes a putative methyltransferase-domain protein, which we show here to be required for citric acid production in an A. niger lab strain (N402) and in other citric acid production strains. The unexpected link between LaeA and citric acid production could provide new insights into the transcriptional control mechanisms related to citric acid production in A. niger. Interestingly, the secondary metabolite profile of a ΔlaeA strain differed from the wild-type strain, showing both decreased and increased metabolite levels, indicating that LaeA is also involved in regulating the production of secondary metabolites. Finally, we show that our systems genetics approach is a powerful tool to identify trait mutations. Copyright © 2016 Niu et al.

  4. Identification of a classical mutant in the industrial host Aspergillus niger by systems genetics: LaeA is required for citric acid production and regulates the formation of some secondary metabolites

    DOE PAGES

    Niu, Jing; Arentshorst, Mark; Nair, P. Deepa S.; ...

    2015-11-13

    The asexual filamentous fungus Aspergillus niger is an important industrial cell factory for citric acid production. In this study, we genetically characterized a UV-generated A. niger mutant that was originally isolated as a nonacidifying mutant, which is a desirable trait for industrial enzyme production. Physiological analysis showed that this mutant did not secrete large amounts of citric acid and oxalic acid, thus explaining the nonacidifying phenotype. As traditional complementation approaches to characterize the mutant genotype were unsuccessful, we used bulk segregant analysis in combination with high-throughput genome sequencing to identify the mutation responsible for the nonacidifying phenotype. Since A. nigermore » has no sexual cycle, parasexual genetics was used to generate haploid segregants derived from diploids by loss of whole chromosomes. We found that the nonacidifying phenotype was caused by a point mutation in the laeA gene. LaeA encodes a putative methyltransferase-domain protein, which we show here to be required for citric acid production in an A. niger lab strain (N402) and in other citric acid production strains. The unexpected link between LaeA and citric acid production could provide new insights into the transcriptional control mechanisms related to citric acid production in A. niger. Interestingly, the secondary metabolite profile of a Δ laeA strain differed from the wild-type strain, showing both decreased and increased metabolite levels, indicating that LaeA is also involved in regulating the production of secondary metabolites. As a result, we show that our systems genetics approach is a powerful tool to identify trait mutations.« less

  5. Identification of a classical mutant in the industrial host Aspergillus niger by systems genetics: LaeA is required for citric acid production and regulates the formation of some secondary metabolites

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Niu, Jing; Arentshorst, Mark; Nair, P. Deepa S.

    The asexual filamentous fungus Aspergillus niger is an important industrial cell factory for citric acid production. In this study, we genetically characterized a UV-generated A. niger mutant that was originally isolated as a nonacidifying mutant, which is a desirable trait for industrial enzyme production. Physiological analysis showed that this mutant did not secrete large amounts of citric acid and oxalic acid, thus explaining the nonacidifying phenotype. As traditional complementation approaches to characterize the mutant genotype were unsuccessful, we used bulk segregant analysis in combination with high-throughput genome sequencing to identify the mutation responsible for the nonacidifying phenotype. Since A. nigermore » has no sexual cycle, parasexual genetics was used to generate haploid segregants derived from diploids by loss of whole chromosomes. We found that the nonacidifying phenotype was caused by a point mutation in the laeA gene. LaeA encodes a putative methyltransferase-domain protein, which we show here to be required for citric acid production in an A. niger lab strain (N402) and in other citric acid production strains. The unexpected link between LaeA and citric acid production could provide new insights into the transcriptional control mechanisms related to citric acid production in A. niger. Interestingly, the secondary metabolite profile of a Δ laeA strain differed from the wild-type strain, showing both decreased and increased metabolite levels, indicating that LaeA is also involved in regulating the production of secondary metabolites. As a result, we show that our systems genetics approach is a powerful tool to identify trait mutations.« less

  6. VizieR Online Data Catalog: z=4.5 and z=5.7 LAEs properties with Spitzer (Finkelstein+, 2015)

    NASA Astrophysics Data System (ADS)

    Finkelstein, K. D.; Finkelstein, S. L.; Tilvi, V.; Malhotra, S.; Rhoads, J. E.; Grogin, N. A.; Pirzkal, N.; Dey, A.; Jannuzi, B. T.; Mobasher, B.; Pakzad, S.; Salmon, B.; Wang, J.

    2017-10-01

    The LAEs targeted by the Spitzer survey were discovered by the Large Area Lyman Alpha (LALA) Survey (Rhoads et al. 2000ApJ...545L..85R), which includes the Bootes field and has accompanying deep broadband imaging in B, V, R, I, and z' bands taken with the MOSAIC camera on the 4 m Mayall telescope at the Kitt Peak National Observatory. To select the z=4.5 and 5.7 LAE candidates the following criteria were used: (1) a secure detection (>5σ) in the narrowband filter; (2) a strong narrowband excess, i.e., the flux density in the narrowband should exceed that in the broadband at the 4σ level, this is done by requiring a narrowband-broadband color <-0.75 mag; and (3) no flux at wavelengths shorter than the expected Lyman break. The last condition implies that at z=4.5, sources are undetected in the B-band, while for z=5.7 sources, they are undetected in both the B-band and V-band. (5 data files).

  7. Effect of equal channel angular pressing on in vitro degradation of LAE442 magnesium alloy.

    PubMed

    Minárik, Peter; Jablonská, Eva; Král, Robert; Lipov, Jan; Ruml, Tomáš; Blawert, Carsten; Hadzima, Branislav; Chmelík, František

    2017-04-01

    Effect of processing by equal channel angular pressing (ECAP) on the degradation behaviour of extruded LAE442 magnesium alloy was investigated in a 0.1M NaCl solution, Kirkland's biocorrosion medium (KBM) and Minimum Essential Medium (MEM), both with and without 10% of foetal bovine serum (FBS). Uniform degradation of as extruded and ECAP processed samples in NaCl solution was observed, nevertheless higher corrosion resistance was found in the latter material. The increase of corrosion resistance due to ECAP was observed also after 14-days immersion in all media used. Higher compactness of the corrosion layer formed on the samples after ECAP was responsible for the observed decrease of corrosion resistance, which was proven by scanning electron microscope investigation. Lower corrosion rate in media with FBS was observed and was explained by additional effect of protein incorporation on the corrosion layer stability. A cytotoxicity test using L929 cells was carried out to investigate possible effect of processing on the cell viability. Sufficient cytocompatibility of the extruded samples was observed with no adverse effects of the subsequent ECAP processing. In conclusion, this in vitro study proved that the degradation behaviour of the LAE442 alloy could be improved by subsequent ECAP processing and this material is a good candidate for future in vivo investigation. Copyright © 2016 Elsevier B.V. All rights reserved.

  8. Degradation behaviour of LAE442-based plate-screw-systems in an in vitro bone model.

    PubMed

    Wolters, Leonie; Besdo, Silke; Angrisani, Nina; Wriggers, Peter; Hering, Britta; Seitz, Jan-Marten; Reifenrath, Janin

    2015-04-01

    The use of absorbable implant materials for fixation after bone fracture helps to avoid a second surgery for implant removal and the risks and costs involved. Magnesium (Mg) is well known as a potential metallic material for degradable implants. The aim of the present in vitro study was to evaluate if degradable LAE442-based magnesium plate-screw-systems are suitable candidates for osteosynthesis implants in load-bearing bones. The corrosion behaviour was tested concerning the influence of different surface treatments, coatings and screw torques. Steel plates and screws of the same size served as control. Plates without special treatment screwed on up to a specified torque of 15cNm or 7cNm, NaOH treated plates (15cNm), magnesium fluoride coated plates (15cNm) and steel plates as control (15cNm) were examined in pH-buffered, temperature-controlled SBF solution for two weeks. The experimental results indicate that the LAE442 plates and screws coated with magnesium fluoride revealed a lower hydrogen evolution in SBF solution as well as a lower weight loss and volume decrease in μ-computed tomography (μCT). The nanoindentation and SEM/EDX measurements at several plate areas showed no significant differences. Summarized, the different screw torques did not affect the corrosion behaviour differently. Also the NaOH treatment seemed to have no essential influence on the degradation kinetics. The plates coated with magnesium fluoride showed a decreased corrosion rate. Hence, it is recommended to consider this coating for the next in vivo study. Copyright © 2015 Elsevier B.V. All rights reserved.

  9. Global distribution of the Energetic Neutral Atom (ENA) / precipitating ion particulate albedo from Low Altitude Emission (LAE) source regions over the last solar maximum

    NASA Astrophysics Data System (ADS)

    Mackler, D. A.; Jahn, J.; Mukherjee, J.; Pollock, C. J.

    2012-12-01

    Charge exchange between ring current ions spiraling into the upper atmosphere and terrestrial neutral constituents produces a non-isotropic distribution of escaping Energetic Neutral Atoms (ENA). These ENA's are no longer tied to the magnetic field, and can therefore be observed remotely from orbiting platforms. Particularly of interest is Low Altitude Emissions (LAE) of ENA's. These ENA emissions occur near the oxygen exobase and constitute the brightest ENA signatures during geomagnetic storms. In this study we build on previous work described in Pollock et al. [2009] in which IMAGE/MENA data was used to compute the Invariant Latitude (IL) and Magnetic Local Time (MLT) distributions of ENA's observed in the 29 October 2003 storm. The algorithms developed in Pollock et al. [2009] are used to compute the IL and MLT of LAE source regions for 76 identified storms at different phases of solar cycle 23. The ENA flux from the source regions are divided by in-situ ion precipitation obtained by DMSP-SSJ4 and NOAA-TED to give a global mapping of the particulate albedo during storm times.

  10. Enhanced citric acid production in aspergillus with inactivated asparagine-linked glycosylation protein 3 (ALG3), and/or increased laeA expression

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Dai, Ziyu; Baker, Scott E.

    Provided herein are fungi, such as Aspergillus niger, having a dolichyl-P-Man:Man(5)GlcNAc(2)-PP-dolichyl mannosyltransferase (Alg3) gene genetic inactivation, increased expression of a loss of aflR expression A (Lae), or both. In some examples, such mutants have several phenotypes, including an increased production of citric acid relative to the parental strain. Methods of using the disclosed fungi to make citric acid are also provided, as are compositions and kits including the disclosed fungi.

  11. Spatial distribution of microbial biomass, activity, community structure, and the biodegradation of linear alkylbenzene sulfonate (LAS) and linear alcohol ethoxylate (LAE) in the subsurface.

    PubMed

    Federle, T W; Ventullo, R M; White, D C

    1990-12-01

    The vertical distribution of microbial biomass, activity, community structure and the mineralization of xenobiotic chemicals was examined in two soil profiles in northern Wisconsin. One profile was impacted by infiltrating wastewater from a laundromat, while the other served as a control. An unconfined aquifer was present 14 meters below the surface at both sites. Biomass and community structure were determined by acridine orange direct counts and measuring concentrations of phospholipid-derived fatty acids (PLFA). Microbial activity was estimated by measuring fluorescein diacetate (FDA) hydrolysis, thymidine incorporation into DNA, and mixed amino acid (MAA) mineralization. Mineralization kinetics of linear alkylbenzene sulfonate (LAS) and linear alcohol ethoxylate (LAE) were determined at each depth. Except for MAA mineralization rates, measures of microbial biomass and activity exhibited similar patterns with depth. PLFA concentration and rates of FDA hydrolysis and thymidine incorporation decreased 10-100 fold below 3 m and then exhibited little variation with depth. Fungal fatty acid markers were found at all depths and represented from 1 to 15% of the total PLFAs. The relative proportion of tuberculostearic acid (TBS), an actinomycete marker, declined with depth and was not detected in the saturated zone. The profile impacted by wastewater exhibited higher levels of PLFA but a lower proportion of TBS than the control profile. This profile also exhibited faster rates of FDA hydrolysis and amino acid mineralization at most depths. LAS was mineralized in the upper 2 m of the vadose zone and in the saturated zone of both profiles. Little or no LAS biodegradation occurred at depths between 2 and 14 m. LAE was mineralized at all depths in both profiles, and the mineralization rate exhibited a similar pattern with depth as biomass and activity measurements. In general, biomass and biodegradative activities were much lower in groundwater than in soil samples obtained

  12. Microstructure characterization of LAE442 magnesium alloy processed by extrusion and ECAP

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Minárik, Peter; Král, Robert; Pešička, Josef

    2016-02-15

    The magnesium alloy LAE442 was processed by extrusion and equal channel angular pressing (ECAP) to achieve ultrafine grained microstructure. Detailed characterization of the microstructure was performed by scanning electron microscope, electron back scattered diffraction (EBSD) and transmission electron microscope. The initial, as-cast, microstructure consisted of large grains of ~ 1 mm. The grain refinement due to the processing by severe plastic deformation led to a decrease of the average grain size to ~ 1.7 μm after the final step of ECAP. A detailed characterization of secondary phases showed the precipitation of Al{sub 11}RE{sub 3}, Al{sub 2}Ca and Al{sub 10}RE{sub 2}Mn{submore » 7} intermetallic phases. X-ray diffraction measurements proved that Li is dissolved within the magnesium matrix in the as-cast condition. Newly formed Al{sub 3}Li phase was observed after ECAP. The texture formation due to the extrusion and ECAP was different from that in the other magnesium alloys due to the activation of non-basal slip systems as a result of the decrease of the c/a ratio. - Highlights: • Combined extrusion and equal channel angular pressing results in significant grain refinement by factor 1000 approximately. • Al{sub 11}RE{sub 3}, Al{sub 2}Ca and Al{sub 10}RE{sub 2}Mn{sub 7} secondary phases are present in the as-cast material while Li was dissolved in the Mg matrix. • Extrusion and ECAP have no effect on the composition of the secondary phases but they influence strongly their distribution. • Texture evolution is affected by decrease of c/a ratio due to the presence of Li and resulting activation of non-basal slip.« less

  13. Nanoemulsions of thymol and eugenol co-emulsified by lauric arginate and lecithin.

    PubMed

    Ma, Qiumin; Davidson, P Michael; Zhong, Qixin

    2016-09-01

    Lauric arginate (LAE) is a cationic surfactant with excellent antimicrobial activities. To incorporate essential oil components (EOCs) in aqueous systems, properties of EOC nanoemulsions prepared with a LAE and lecithin mixture were studied. The LAE-lecithin mixture resulted in stable translucent nanoemulsions of thymol and eugenol with spherical droplets smaller than 100nm, contrasting with the turbid emulsions prepared with individual emulsifiers. Zeta-potential data suggested the formation of LAE-lecithin complexes probably through hydrophobic interaction. Negligible difference was observed for antimicrobial activities of nanoemulsions and LAE in tryptic soy broth. In 2% reduced fat milk, nanoemulsions showed similar antilisterial activities compared to free LAE in inhibiting Listeria monocytogenes, but was less effective against Escherichia coli O157:H7 than free LAE, which was correlated with the availability of LAE as observed in release kinetics. Therefore, mixing LAE with lecithin improved the physical properties of EOC nanoemulsions but did not improve antimicrobial activities, especially against Gram-negative bacteria. Copyright © 2016 Elsevier Ltd. All rights reserved.

  14. Antimicrobial activity of lauric arginate-coated polylactic acid films against Listeria monocytogenes and Salmonella typhimurium on cooked sliced ham.

    PubMed

    Theinsathid, Pornpun; Visessanguan, Wonnop; Kruenate, Jittiporn; Kingcha, Yutthana; Keeratipibul, Suwimon

    2012-02-01

    A novel type of environmentally friendly packaging with antibacterial activity was developed from lauric arginate (LAE)-coating of polylactic acid (PLA) films after surface activation using a corona discharge. Scanning electron microscopy (SEM)-based analysis of the LAE/PLA films confirmed the successful coating of LAE on the PLA surface. The mechanical properties of the LAE/PLA films with different levels of LAE-coating (0% to 2.6%[w/w]) were essentially the same as those of the neat PLA film. The antibacterial activity of the LAE/PLA films against Listeria monocytogenes and Salmonella enterica Serovar Typhimurium (S. Typhimurium) was confirmed by a qualitative modified agar diffusion assay and quantitative JIS Z 2801:2000 method. Using the LAE/PLA film as a food-contact antimicrobial packaging for cooked cured ham, as a model system, suggested a potential application to inhibit L. monocytogenes and S. Typhimurium on ham with a 0.07% (w/w) LAE coating on the PLA when high transparency is required, as evidenced from the 2 to 3 log CFU/tested film lower pathogen growth after 7 d storage but even greater antibacterial activity is obtained with a LAE coating level of 2.6% (w/w) but at the cost of a reduced transparency of the finished product. This article shows how we can simply develop functional green packaging of PLA for food with effective and efficient antimicrobial activity by use of LAE coating on the surface via corona discharge. The effectiveness of an innovative antimicrobial LAE-coated PLA film against foodborne pathogens was demonstrated. Importantly, the application of the LAE to form the LAE-coated PLA film can be customized within current film manufacturing lines. © 2012 Institute of Food Technologists®

  15. Fabrication, stability and efficacy of dual-component antimicrobial nanoemulsions: essential oil (thyme oil) and cationic surfactant (lauric arginate).

    PubMed

    Chang, Yuhua; McLandsborough, Lynne; McClements, David Julian

    2015-04-01

    The influence of a cationic surfactant (lauric arginate, LAE) on the physical properties and antimicrobial efficacy of thyme oil nanoemulsions was investigated. Nanoemulsions prepared from pure thyme oil were highly unstable due to Ostwald ripening, but they could be stabilized by adding a ripening inhibitor (corn oil) to the oil phase prior to homogenisation. The loading capacity and antimicrobial efficacy of thyme oil nanoemulsions were significantly increased by adding LAE. In the absence of LAE, at least 60 wt% corn oil had to be added to the lipid phase to inhibit Ostwald ripening; but in the presence of 0.1 wt% LAE, only 30 wt% corn oil was needed. LAE addition substantially increased the antimicrobial efficacy of the thyme oil nanoemulsions: 200 μg/ml thyme oil was needed to inhibit growth of a spoilage yeast (Zygosaccharomyces bailii) if LAE was added, whereas ⩾ 400 μg/ml was needed in the absence of LAE. Copyright © 2014 Elsevier Ltd. All rights reserved.

  16. Anti-allergic effects of Lycopus lucidus on mast cell-mediated allergy model

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Shin, Tae-Yong; Kim, Sang-Hyun; Suk, Kyoungho

    2005-12-15

    The current study characterizes the mechanism by which the aqueous extract of Lycopus lucidus Turcz. (Labiatae) (LAE) decreases mast cell-mediated immediate-type allergic reaction. The immediate-type allergic reaction is involved in many allergic diseases such as asthma and allergic rhinitis. LAE has been used as a traditional medicine in Korea and is known to have an anti-inflammatory effect. However, its specific mechanism of action is still unknown. LAE was anally administered to mice for high and fast absorption. LAE inhibited compound 48/80-induced systemic reactions in mice. LAE decreased the local allergic reaction, passive cutaneous anaphylaxis, activated by anti-dinitrophenyl (DNP) IgE antibody.more » LAE dose-dependently reduced histamine release from rat peritoneal mast cells activated by compound 48/80 or anti-DNP IgE. Furthermore, LAE decreased the secretion of TNF-{alpha} and IL-6 in phorbol 12-myristate 13-acetate (PMA) plus calcium ionophore A23187-stimulated human mast cells. The inhibitory effect of LAE on the pro-inflammatory cytokine was p38 mitogen-activated protein kinase (MAPK) and nuclear factor-{kappa}B (NF-{kappa}B) dependent. LAE attenuated PMA plus A23187-induced degradation of I{kappa}B{alpha} and nuclear translocation of NF-{kappa}B, and specifically blocked activation of p38 MAPK, but not that of c-jun N-terminal kinase and extracellular signal-regulated kinase. Our findings provide evidence that LAE inhibits mast cell-derived immediate-type allergic reactions and involvement of pro-inflammatory cytokines, p38 MAPK, and NF-{kappa}B in these effects.« less

  17. Modelling of Lyman-alpha emitting galaxies and ionized bubbles at the epoch of reionization

    NASA Astrophysics Data System (ADS)

    Yajima, Hidenobu; Sugimura, Kazuyuki; Hasegawa, Kenji

    2018-04-01

    Understanding {Ly{α }} emitting galaxies (LAEs) can be a key to reveal cosmic reionization and galaxy formation in the early Universe. Based on halo merger trees and {Ly{α }} radiation transfer calculations, we model redshift evolution of LAEs and their observational properties at z ≥ 6. We consider ionized bubbles associated with individual LAEs and IGM transmission of {Ly{α }} photons. We find that {Ly{α }} luminosity tightly correlates with halo mass and stellar mass, while the relation with star formation rate has a large dispersion. Comparing our models with the observed luminosity function by Konno et al., we suggest that LAEs at z ˜ 7 have galactic wind of V_out ≳ 100 km s^{-1} and HI column density of N_HI ≳ 10^{20} cm^{-2}. Number density of bright LAEs rapidly decreases as redshift increases, due to both lower star formation rate and smaller HII bubbles. Our model predicts future wide deep surveys with next generation telescopes, such as JWST, E-ELT and TMT, can detect LAEs at z ˜ 10 with a number density of n_LAE ˜ a few × 10^{-6} Mpc^{-3} for the flux sensitivity of 10^{-18} erg cm^{-2} s^{-1}. When giant HII bubbles are formed by clustering LAEs, the number density of observable LAEs can increase by a factor of few. By combining these surveys with future 21-cm observations, it could be possible to detect both LAEs with L_{Lyα }≳ 10^{42} erg s^{-1} and their associated giant HII bubbles with the size ≳ 250 kpc at z ˜ 10.

  18. On-Premise Alcohol Establishments and Ambulance Calls for Trauma, Assault, and Intoxication

    PubMed Central

    Ray, Joel G.; Turner, Linda; Gozdyra, Piotr; Matheson, Flora I.; Robert, Burgess; Bartsch, Emily; Park, Alison L.

    2016-01-01

    Abstract Alcohol contributes to intentional and unintentional injury. We explored on-premise licensed alcohol establishments (LAEs) and emergency medical service (EMS) ambulance calls. We completed a retrospective population-based study in the Region of Peel, Ontario, 2005 to 2014, where alcohol sales are tightly regulated and healthcare is universally available. We included participants age ≥ 19 years. Longitude–latitude coordinates of all 696 LAEs and all 267,477 EMS ambulance calls were ascertained, and then assigned to 1 of 1568 dissemination areas (DA) in Peel. Relative risks (RRs) described the association between density of on-premise LAEs (by DA deciles) and the rate of EMS calls, adjusted for material deprivation, and density of beer/liquor stores in each DA. There was a curvilinear relation between LAE density and EMS calls for trauma, rising from 45.3 per 1000 in DAs with no LAEs to 381.0 per 1000 in decile-10 (adjusted RR 7.83, 95% confidence interval [CI] 6.15–9.97). This relation was more pronounced for alcohol-focused LAEs, and highest among younger males. Calls for assault (RR 2.67, 95% CI 1.26–5.65) and intoxication (RR 4.00, 95% CI 1.41–11.38) were more likely on the last day of the month and the day thereafter, compared to 1 week prior. At 02:00 hours, when LAEs must stop selling alcohol, there was a considerable rise in assault-related calls in DAs with LAE but not in DAs without LAEs. On-premise LAEs contribute to EMS calls for trauma and assault, especially among young males, around last call, and when monthly pay cheques are cashed. PMID:27175699

  19. An observational study of the relationship between precipitating ions and ENAs emerging from the ion/atmosphere interaction region

    NASA Astrophysics Data System (ADS)

    Mackler, David A.

    Plasmasheet particles transported Earthward during times of active magnetospheric convection can interact with thermospheric neutrals through charge exchange. The resulting Energetic Neutral Atoms (ENAs) are free to leave the influence of the magnetosphere and can be remotely detected. ENAs associated with low altitude (300--800 km) ion precipitation in the high latitude atmosphere/ionosphere are termed Low Altitude Emissions (LAEs). Remotely observed LAEs are highly non-isotropic in velocity space such that the pitch angle distribution at the time of charge exchange is near 90 degrees. The Geomagnetic Emission Cone (GEC) of LAEs can be mapped spatially, showing where proton energy is deposited during times of varying geomagnetic activity. In this study we present a statistical look at the correlation between LAE flux (intensity and location) and geomagnetic activity as well as comparisons of LAE signatures with in situ ion precipitation. The LAE data is from the MENA imager on the IMAGE satellite over the declining phase of solar cycle 23 (2000--2005). The SYM-H, AE, and Kp indices are used to describe geomagnetic activity. The in situ data is from the Defense Meteorological Satellite Program (DMSP). The goal of the study is to evaluate properties of LAEs in ENA images and determine if those images can be used to infer properties of ion precipitation. Results indicate a general positive correlation to LAE flux for all three indices, with the SYM-H showing the greatest non-linearity. The MLT distribution of LAEs are centered about midnight and spread with increasing activity. The Invariant Latitude for all indices has a slightly negative correlation. The combined results indicate that both LAE and DMSP data behave similarly to geomagnetic activity. LAEs are more spread out in latitude, possibly due to multiple charge exchange interactions, while the in situ data changes to lower latitudes dramatically with increasing flux. The bulk of the data indicates that the

  20. Modelling of Lyman-alpha emitting galaxies and ionized bubbles at the epoch of reionization

    NASA Astrophysics Data System (ADS)

    Yajima, Hidenobu; Sugimura, Kazuyuki; Hasegawa, Kenji

    2018-07-01

    Understanding {Ly{α}} emitting galaxies (LAEs) can be a key to reveal cosmic reionization and galaxy formation in the early Universe. Based on halo merger trees and {Ly{α}} radiation transfer calculations, we model redshift evolution of LAEs and their observational properties at z ≥ 6. We consider ionized bubbles associated with individual LAEs and IGM (integer-galactic medium) transmission of {Ly{α}} photons. We find that {Ly{α}} luminosity tightly correlates with halo mass and stellar mass, while the relation with star formation rate has a large dispersion. Comparing our models with the observed luminosity function by Konno et al., we suggest that LAEs at z ˜ 7 have galactic wind of V_out ≳ 100 km s^{-1} and H I column density of N_HI ≳ 10^{20} cm^{-2}. Number density of bright LAEs rapidly decreases as redshift increases, due to both lower star formation rate and smaller H II bubbles. Our model predicts future wide deep surveys with next-generation telescopes, such as James Webb Space Telescope, European Extremely Large Telescope, and Thirty Metre Telescope, can detect LAEs at z ˜ 10 with a number density of n_LAE ˜ {a few } × 10^{-6} Mpc^{-3} for the flux sensitivity of 10^{-18} erg cm^{-2} s^{-1}. When giant H II bubbles are formed by clustering LAEs, the number density of observable LAEs can increase by a factor of few. By combining these surveys with future 21-cm observations, it could be possible to detect both LAEs with L_{Lyα }≳ 10^{42} erg s^{-1} and their associated giant H II bubbles with the size {≳ } 250 kpc at z ˜ 10.

  1. Statistical correlation of low-altitude ENA emissions with geomagnetic activity from IMAGE/MENA observations

    NASA Astrophysics Data System (ADS)

    Mackler, D. A.; Jahn, J.-M.; Perez, J. D.; Pollock, C. J.; Valek, P. W.

    2016-03-01

    Plasma sheet particles transported Earthward during times of active magnetospheric convection can interact with exospheric/thermospheric neutrals through charge exchange. The resulting Energetic Neutral Atoms (ENAs) are free to leave the influence of the magnetosphere and can be remotely detected. ENAs associated with low-altitude (300-800 km) ion precipitation in the high-latitude atmosphere/ionosphere are termed low-altitude emissions (LAEs). Remotely observed LAEs are highly nonisotropic in velocity space such that the pitch angle distribution at the time of charge exchange is near 90°. The Geomagnetic Emission Cone of LAEs can be mapped spatially, showing where proton energy is deposited during times of varying geomagnetic activity. In this study we present a statistical look at the correlation between LAE flux (intensity and location) and geomagnetic activity. The LAE data are from the MENA imager on the IMAGE satellite over the declining phase of solar cycle 23 (2000-2005). The SYM-H, AE, and Kp indices are used to describe geomagnetic activity. The goal of the study is to evaluate properties of LAEs in ENA images and determine if those images can be used to infer properties of ion precipitation. Results indicate a general positive correlation to LAE flux for all three indices, with the SYM-H showing the greatest sensitivity. The magnetic local time distribution of LAEs is centered about midnight and spreads with increasing activity. The invariant latitude for all indices has a slightly negative correlation. The combined results indicate LAE behavior similar to that of ion precipitation.

  2. Statistical Correlation of Low-Altitude ENA Emissions with Geomagnetic Activity from IMAGE MENA Observations

    NASA Technical Reports Server (NTRS)

    Mackler, D. A.; Jahn, J.- M.; Perez, J. D.; Pollock, C. J.; Valek, P. W.

    2016-01-01

    Plasma sheet particles transported Earthward during times of active magnetospheric convection can interact with exospheric/thermospheric neutrals through charge exchange. The resulting Energetic Neutral Atoms (ENAs) are free to leave the influence of the magnetosphere and can be remotely detected. ENAs associated with low-altitude (300-800 km) ion precipitation in the high-latitude atmosphere/ionosphere are termed low-altitude emissions (LAEs). Remotely observed LAEs are highly nonisotropic in velocity space such that the pitch angle distribution at the time of charge exchange is near 90deg. The Geomagnetic Emission Cone of LAEs can be mapped spatially, showing where proton energy is deposited during times of varying geomagnetic activity. In this study we present a statistical look at the correlation between LAE flux (intensity and location) and geomagnetic activity. The LAE data are from the MENA imager on the IMAGE satellite over the declining phase of solar cycle 23 (2000-2005). The SYM-H, AE, and Kp indices are used to describe geomagnetic activity. The goal of the study is to evaluate properties of LAEs in ENA images and determine if those images can be used to infer properties of ion precipitation. Results indicate a general positive correlation to LAE flux for all three indices, with the SYM-H showing the greatest sensitivity. The magnetic local time distribution of LAEs is centered about midnight and spreads with increasing activity. The invariant latitude for all indices has a slightly negative correlation. The combined results indicate LAE behavior similar to that of ion precipitation.

  3. Formulation and Stabilization of Concentrated Edible Oil-in-Water Emulsions Based on Electrostatic Complexes of a Food-Grade Cationic Surfactant (Ethyl Lauroyl Arginate) and Cellulose Nanocrystals.

    PubMed

    Bai, Long; Xiang, Wenchao; Huan, Siqi; Rojas, Orlando J

    2018-05-14

    We report on high-internal-phase, oil-in-water Pickering emulsions that are stable against coalescence during storage. Viscous, edible oil (sunflower) was emulsified by combining naturally derived cellulose nanocrystals (CNCs) and a food-grade, biobased cationic surfactant obtained from lauric acid and L-arginine (ethyl lauroyl arginate, LAE). The interactions between CNC and LAE were elucidated by isothermal titration calorimetry (ITC) and supplementary techniques. LAE adsorption on CNC surfaces and its effect on nanoparticle electrostatic stabilization, aggregation state, and emulsifying ability was studied and related to the properties of resultant oil-in-water emulsions. Pickering systems with tunable droplet diameter and stability against oil coalescence during long-term storage were controllably achieved depending on LAE loading. The underlying stabilization mechanism was found to depend on the type of complex formed, the LAE structures adsorbed on the cellulose nanoparticles (as unimer or as adsorbed admicelles), the presence of free LAE in the aqueous phase, and the equivalent alkane number of the oil phase (sunflower and dodecane oils were compared). The results extend the potential of CNC in the formulation of high-quality and edible Pickering emulsions. The functional properties imparted by LAE, a highly effective molecule against food pathogens and spoilage organisms, open new opportunities in food, cosmetics, and pharmaceutical applications, where the presence of CNC plays a critical role in achieving synergistic effects with LAE.

  4. The VIMOS Ultra Deep Survey: Lyα emission and stellar populations of star-forming galaxies at 2 < z < 2.5

    NASA Astrophysics Data System (ADS)

    Hathi, N. P.; Le Fèvre, O.; Ilbert, O.; Cassata, P.; Tasca, L. A. M.; Lemaux, B. C.; Garilli, B.; Le Brun, V.; Maccagni, D.; Pentericci, L.; Thomas, R.; Vanzella, E.; Zamorani, G.; Zucca, E.; Amorín, R.; Bardelli, S.; Cassarà, L. P.; Castellano, M.; Cimatti, A.; Cucciati, O.; Durkalec, A.; Fontana, A.; Giavalisco, M.; Grazian, A.; Guaita, L.; Koekemoer, A.; Paltani, S.; Pforr, J.; Ribeiro, B.; Schaerer, D.; Scodeggio, M.; Sommariva, V.; Talia, M.; Tresse, L.; Vergani, D.; Capak, P.; Charlot, S.; Contini, T.; Cuby, J. G.; de la Torre, S.; Dunlop, J.; Fotopoulou, S.; López-Sanjuan, C.; Mellier, Y.; Salvato, M.; Scoville, N.; Taniguchi, Y.; Wang, P. W.

    2016-04-01

    The aim of this paper is to investigate spectral and photometric properties of 854 faint (IAB ≲ 25 mag) star-forming galaxies (SFGs) at 2 < z < 2.5 using the VIMOS Ultra-Deep Survey (VUDS) spectroscopic data and deep multi-wavelength photometric data in three extensively studied extragalactic fields (ECDFS, VVDS, COSMOS). These SFGs were targeted for spectroscopy as a result of their photometric redshifts. The VUDS spectra are used to measure the UV spectral slopes (β) as well as Lyα equivalent widths (EW). On average, the spectroscopically measured β (-1.36 ± 0.02), is comparable to the photometrically measured β (-1.32 ± 0.02), and has smaller measurement uncertainties. The positive correlation of β with the spectral energy distribution (SED)-based measurement of dust extinction Es(B-V) emphasizes the importance of β as an alternative dust indicator at high redshifts. To make a proper comparison, we divide these SFGs into three subgroups based on their rest-frame Lyα EW: SFGs with no Lyα emission (SFGN; EW ≤ 0 Å), SFGs with Lyα emission (SFGL; EW > 0 Å), and Lyα emitters (LAEs; EW ≥ 20 Å). The fraction of LAEs at these redshifts is ~10%, which is consistent with previous observations. We compared best-fitSED-estimated stellar parameters of the SFGN, SFGL and LAE samples. For the luminosities probed here (~ L∗), we find that galaxies with and without Lyα in emission have small but significant differences in their SED-based properties. We find that LAEs have less dust, and lower star-formation rates (SFR) compared to non-LAEs. We also find that LAEs are less massive compared to non-LAEs, though the difference is smaller and less significant compared to the SFR and Es(B-V). When we divide the LAEs according to their Spitzer/IRAC 3.6 μm fluxes, we find that the fraction of IRAC-detected (m3.6 ≲ 25 mag) LAEs is much higher than the fraction of IRAC-detected narrow band (NB)-selected LAEs at z ≃ 2-3. This could imply that UV-selected LAEs

  5. In vivo evaluation of a magnesium-based degradable intramedullary nailing system in a sheep model.

    PubMed

    Rössig, Christina; Angrisani, Nina; Helmecke, Patrick; Besdo, Silke; Seitz, Jan-Marten; Welke, Bastian; Fedchenko, Nickolay; Kock, Heiko; Reifenrath, Janin

    2015-10-01

    The biocompatibility and the degradation behavior of the LAE442 magnesium-based intramedullary interlocked nailing system (IM-NS) was assessed in vivo in a comparative study (stainless austenitic steel 1.4441LA) for the first time. IM-NS was implanted into the right tibia (24-week investigation period; nails/screws diameter: 9 mm/3.5 mm, length: 130 mm/15-40 mm) of 10 adult sheep (LAE442, stainless steel, n=5 each group). Clinical and radiographic examinations, in vivo computed tomography (CT), ex vivo micro-computed tomography (μCT), mechanical and histological examinations and element analyses of alloying elements in inner organs were performed. The mechanical examinations (four-point bending) revealed a significant decrease of LAE442 implant stiffness, force at 0.2% offset yield point and maximum force. Periosteal (new bone formation) and endosteal (bone decline) located bone alterations occurred in both groups (LAE442 alloy more pronounced). Moderate gas formation was observed within the LAE442 alloy group. The CT-measured implant volume decreased slightly (not significant). Histologically a predominantly direct bone-to-implant interface existed within the LAE442 alloy group. Formation of a fibrous tissue capsule around the nail occurred in the steel group. Minor inflammatory infiltration was observed in the LAE442 alloy group. Significantly increased quantities of rare earth elements were detected in the LAE442 alloy group. μCT examination showed the beginning of corrosion in dependence of the surrounding tissue. After 24 weeks the local biocompatibility of LAE442 can be considered as suitable for a degradable implant material. An application oriented interlocked intramedullary nailing system in a comparative study (degradable magnesium-based LAE442 alloy vs. steel alloy) was examined in a sheep model for the first time. We focused in particular on the examination of implant degradation by means of (μ-)CT, mechanical properties (four-point bending

  6. DOE Office of Scientific and Technical Information (OSTI.GOV)

    Yang, Huan; Wang, JunXian; Zheng, Zhen-Ya

    Using the Lyα emission line as a tracer of high-redshift, star-forming galaxies, hundreds of Lyα emission line galaxies (LAEs) at z > 5 have been detected. These LAEs are considered to be low-mass young galaxies, critical to the re-ionization of the universe and the metal enrichment of the circumgalactic medium (CGM) and the intergalactic medium (IGM). It is assumed that outflows in LAEs can help both ionizing photons and Lyα photons escape from galaxies. However, we still know little about the outflows in high-redshift LAEs due to observational difficulties, especially at redshift >5. Models of Lyα radiative transfer predict asymmetricmore » Lyα line profiles with broad red wings in LAEs with outflows. Here, we report a z ∼ 5.7 Lyα emission line with a broad red wing extending to >1000 km s{sup –1} relative to the peak of Lyα line, which has been detected in only a couple of z > 5 LAEs until now. If the broad red wing is ascribed to gas outflow instead of active galactic nucleus activity, the outflow velocity could be larger than the escape velocity (∼500 km s{sup –1}) of a typical halo mass of z ∼ 5.7 LAEs, which is consistent with the idea that outflows in LAEs disperse metals to CGM and IGM.« less

  7. Screening Allelochemical-Resistant Species of the Alien Invasive Mikania micrantha for Restoration in South China

    PubMed Central

    Wu, Ai-Ping; Li, Zi-Li; He, Fei-Fei; Wang, Yan-Hong; Dong, Ming

    2015-01-01

    To screen allelochemical-resistant species of the alien invasive weed Mikania micrantha, we studied the allelopathic inhibition effects of the leaf aqueous extract (LAE) of Mikania on seed germination and seedling growth of the 26 species native or naturalized in the invaded region in South China. Seed germination was more strongly negatively affected by LAE than seedling growth. Responses of seed germination and seed growth to LAE differed differently among the target species. LAE more strongly negatively affected seed germination, but less strongly negatively affected seedling growth, in non-legume species than in legume species. LAE more strongly negatively affected seed germination and seedling growth in native species than naturalized exotic species. Therefore, naturalized exotic non-legume seedlings are more suitable than seeds of native legume species for restoration of Mikania-invaded habitats. PMID:26177031

  8. Screening Allelochemical-Resistant Species of the Alien Invasive Mikania micrantha for Restoration in South China.

    PubMed

    Wu, Ai-Ping; Li, Zi-Li; He, Fei-Fei; Wang, Yan-Hong; Dong, Ming

    2015-01-01

    To screen allelochemical-resistant species of the alien invasive weed Mikania micrantha, we studied the allelopathic inhibition effects of the leaf aqueous extract (LAE) of Mikania on seed germination and seedling growth of the 26 species native or naturalized in the invaded region in South China. Seed germination was more strongly negatively affected by LAE than seedling growth. Responses of seed germination and seed growth to LAE differed differently among the target species. LAE more strongly negatively affected seed germination, but less strongly negatively affected seedling growth, in non-legume species than in legume species. LAE more strongly negatively affected seed germination and seedling growth in native species than naturalized exotic species. Therefore, naturalized exotic non-legume seedlings are more suitable than seeds of native legume species for restoration of Mikania-invaded habitats.

  9. Confirmation of a Steep Luminosity Function for Ly alpha Emitters at z 5.7: a Major Component of Reionization

    NASA Technical Reports Server (NTRS)

    Dressler, Alan; Henry, Alaina L.; Martin, Crystal L.; Sawicki, Marcin; McCarthy, Patrick; Villaneuva, Edward

    2014-01-01

    We report the first direct and robust measurement of the faint-end slope of the Ly-alpha emitter (LAE) luminosity function at z = 5.7. Candidate LAEs from a low-spectral-resolution blind search with IMACS on Magellan- Baade were targeted at higher resolution to distinguish high redshift LAEs from foreground galaxies. All but 2 of our 42 single-emission-line systems are fainter than F = 2.0×10(exp-17) ergs s(exp-1) cm(exp-2), making these the faintest emission-lines observed for a z = 5.7 sample with known completeness, an essential property for determining the faint end slope of the LAE luminosity function. We find 13 LAEs as compared to 29 foreground galaxies, in very good agreement with the modeled foreground counts predicted in Dressler et al. (2011a) that had been used to estimate a faint-end slope of alpha = -2.0 for the LAE luminosity function. A 32% LAE fraction, LAE/(LAE+foreground) within the flux interval F = 2-20 × 10(exp-18) ergs s(exp-1) cm(exp-2) constrains the faint end slope of the luminosity function to -1.95 greater than alpha greater than -2.35 (1 delta). We show how this steep LF should provide, to the limit of our observations, more than 20% of the flux necessary to maintain ionization at z = 5.7, with a factor-of-ten extrapolation in flux reaching more than 55%. We suggest that this bodes well for a comparable contribution by similar, low-mass star forming galaxies at higher-redshift - within the reionization epoch at z greater than approximately 7, only 250 Myr earlier - and that such systems provide a substantial, if not dominant, contribution to the late-stage reionization of the IGM.

  10. SILVERRUSH. II. First catalogs and properties of ˜2000 Lyα emitters and blobs at z ˜ 6-7 identified over the 14-21 deg2 sky*

    NASA Astrophysics Data System (ADS)

    Shibuya, Takatoshi; Ouchi, Masami; Konno, Akira; Higuchi, Ryo; Harikane, Yuichi; Ono, Yoshiaki; Shimasaku, Kazuhiro; Taniguchi, Yoshiaki; Kobayashi, Masakazu A. R.; Kajisawa, Masaru; Nagao, Tohru; Furusawa, Hisanori; Goto, Tomotsugu; Kashikawa, Nobunari; Komiyama, Yutaka; Kusakabe, Haruka; Lee, Chien-Hsiu; Momose, Rieko; Nakajima, Kimihiko; Tanaka, Masayuki; Wang, Shiang-Yu; Yuma, Suraphong

    2018-01-01

    We present an unprecedentedly large catalog consisting of 2230 ≳ L* Lyα emitters (LAEs) at z = 5.7 and 6.6 on the 13.8 and 21.2 deg2 sky, respectively, that are identified by the SILVERRUSH program with the first narrow-band imaging data of the Hyper Suprime-Cam (HSC) survey. We confirm that the LAE catalog is reliable on the basis of 96 LAEs whose spectroscopic redshifts are already determined by this program and previous studies. This catalogue is also available online. Based on this catalogue, we derive the rest-frame Lyα equivalent-width distributions of LAEs at z ≃ 5.7-6.6 that are reasonably explained by the exponential profiles with scale lengths of ≃ 120-170 Å, showing no significant evolution from z ≃ 5.7 to z ≃ 6.6. We find that 275 LAEs with large equivalent widths (LEWs) of >240 Å are candidates of young metal poor galaxies and AGNs. We also find that the fraction of LEW LAEs to all LAEs is 4% and 21% at z ≃ 5.7 and z ≃ 6.6, respectively. Our LAE catalog includes 11 Lyα blobs (LABs) that are LAEs with spatially extended Lyα emission with a profile that is clearly distinguished from those of stellar objects at the ≳3σ level. The number density of the LABs at z = 6-7 is ˜10-7-10-6 Mpc-3, being ˜10-100 times lower than those claimed for LABs at z ≃ 2-3, suggestive of disappearing LABs at z ≳ 6, albeit with the different selection methods and criteria for the low and high-z LABs.

  11. Complex Lyα Profiles in Redshift 6.6 Ultraluminous Lyα Emitters

    NASA Astrophysics Data System (ADS)

    Songaila, A.; Hu, E. M.; Barger, A. J.; Cowie, L. L.; Hasinger, G.; Rosenwasser, B.; Waters, C.

    2018-06-01

    We report on a search for ultraluminous Lyα-emitting galaxies (LAEs) at z = 6.6 using the NB921 filter on the Hyper Suprime-Cam on the Subaru telescope. We searched a 30 deg2 area around the north ecliptic pole, which we observed in broadband g‧, r‧, i‧, z‧, and y‧ and narrowband NB816 and NB921, for sources with NB921 < 23.5 and z‧-NB921 > 1.3. This corresponds to a selection of log L(Lyα) > 43.5 erg s‑1. We followed up seven candidate LAEs (out of 13) with the Keck DEIMOS spectrograph and confirmed five z = 6.6 LAEs, one z = 6.6 AGN with a broad Lyα line and a strong red continuum, and one low-redshift ([O III] 5007) galaxy. The five ultraluminous LAEs have wider line profiles than lower-luminosity LAEs, and one source, NEPLA4, has a complex line profile similar to that of COLA1. In combination with previous results, we show that the line profiles of the z = 6.6 ultraluminous LAEs are systematically different from those of lower-luminosity LAEs at this redshift. This result suggests that ultraluminous LAEs generate highly ionized regions of the intergalactic medium in their vicinity that allow the full Lyα profile of the galaxy—including any blue wings—to be visible. If this interpretation is correct, then ultraluminous LAEs offer a unique opportunity to determine the properties of the ionized zones around them, which will help in understanding the ionization of the z ∼ 7 intergalactic medium. A simple calculation gives a very rough estimate of 0.015 for the escape fraction of ionizing photons, but more sophisticated calculations are needed to fully characterize the uncertainties.

  12. Left Atrial Enlargement and Stroke Recurrence: The Northern Manhattan Stroke Study

    PubMed Central

    Yaghi, Shadi; Moon, Yeseon P.; Mora-McLaughlin, Consuelo; Willey, Joshua Z.; Cheung, Ken; Tullio, Marco R. Di; Homma, Shunichi; Kamel, Hooman; Sacco, Ralph L.; Elkind, Mitchell S. V.

    2015-01-01

    Background and purpose While left atrial enlargement (LAE) increases incident stroke risk, the association with recurrent stroke is less clear. Our aim was to determine the association of LAE with recurrent stroke most likely related to embolism (cryptogenic and cardioembolic), and all ischemic stroke recurrences. Methods We followed 655 first ischemic stroke patients in the Northern Manhattan Stroke Study for up to 5 years. LA size from 2-D echocardiography was categorized as normal (52.7%), mild LAE (31.6%), and moderate-severe LAE (15.7%). We used Cox proportional hazard models to calculate the hazard ratios and 95% confidence intervals (HR, 95%CI) for the association of LA size and LAE with recurrent cryptogenic/cardioembolic and total recurrent ischemic stroke. Results LA size was available in 529 (81%) patients. Mean age at enrollment was 69±13 years; 45.8% were male, 54.0% Hispanic, and 18.5% had atrial fibrillation. Over a median of 4 years there were 65 recurrent ischemic strokes (29 were cardioembolic or cryptogenic). In multivariable models adjusted for confounders including atrial fibrillation and heart failure, moderate-severe LAE compared to normal LA size was associated with greater risk of recurrent cardioembolic/cryptogenic stroke (adjusted HR 2.83, 95% CI 1.03-7.81), but not total ischemic stroke (adjusted HR 1.06, 95% CI, 0.48-2.30). Mild LAE was not associated with recurrent stroke. Conclusion Moderate to severe LAE was an independent marker of recurrent cardioembolic or cryptogenic stroke in a multiethnic cohort of ischemic stroke patients. Further research is needed to determine whether anticoagulant use may reduce risk of recurrence in ischemic stroke patients with moderate to severe LAE. PMID:25908460

  13. A High Space Density of Luminous Lyman Alpha Emitters at z ∼ 6.5

    NASA Astrophysics Data System (ADS)

    Bagley, Micaela B.; Scarlata, Claudia; Henry, Alaina; Rafelski, Marc; Malkan, Matthew; Teplitz, Harry; Dai, Y. Sophia; Baronchelli, Ivano; Colbert, James; Rutkowski, Michael; Mehta, Vihang; Dressler, Alan; McCarthy, Patrick; Bunker, Andrew; Atek, Hakim; Garel, Thibault; Martin, Crystal L.; Hathi, Nimish; Siana, Brian

    2017-03-01

    We present the results of a systematic search for Lyα emitters (LAEs) at 6≲ z≲ 7.6 using the HST WFC3 Infrared Spectroscopic Parallel (WISP) Survey. Our total volume over this redshift range is ∼ 8× {10}5 Mpc3, comparable to many of the narrowband surveys despite their larger area coverage. We find two LAEs at z = 6.38 and 6.44 with line luminosities of {L}Lyα }∼ 4.7× {10}43 erg s‑1, putting them among the brightest LAEs discovered at these redshifts. Taking advantage of the broad spectral coverage of WISP, we are able to rule out almost all lower-redshift contaminants. The WISP LAEs have a high number density of 7.7× {10}-6 Mpc‑3. We argue that the LAEs reside in megaparsec-scale ionized bubbles that allow the Lyα photons to redshift out of resonance before encountering the neutral intergalactic medium. We discuss possible ionizing sources and conclude that the observed LAEs alone are not sufficient to ionize the bubbles.

  14. Large arterial elasticity varies as a function of gender and racism-related vigilance in black youth.

    PubMed

    Clark, Rodney; Benkert, Ramona A; Flack, John M

    2006-10-01

    This exploratory study examined the relationship of gender and racism-related vigilance to baseline and task-induced changes in large arterial elasticity (LAE). The convenience sample consisted of 153 black youth (M age = 11.5 years, SD = 1.4) who were normotensive. Large arterial elasticity was measured via pulse wave contour analysis, before, during, and after a sequentially administered digit forward and digit backward task. Racism-related vigilance was reported by participants. Although findings from general linear models indicated that the independent effects of gender and racism-related vigilance were not significantly related to LAE (baseline, reactivity, or recovery) (all p > .05), these analyses showed that gender and racism-related vigilance interacted to predict baseline LAE (p < .02) and task-induced changes (reactivity only) in LAE (p < .006). Follow-up regression analyses explicating the pattern of these interaction effects indicated that 1) racism-related vigilance was marginally and inversely related to baseline LAE among boys (p < .06) but not in girls (p > .21); and, 2) racism-related vigilance was positively and significantly associated with task-induced changes (reactivity) in LAE among boys (p < .008) but not in girls (p > .30). The relationship between racism-related vigilance and LAE varies as a function of gender, and may have longer-term implications for between and within-group disparities in cardiovascular health.

  15. Increased pulse pressure is associated with left atrial enlargement in resistant hypertensive patients.

    PubMed

    Armario, Pedro; Oliveras, Anna; Hernández-Del-Rey, Raquel; Suárez, Carmen; Martell, Nieves; Ruilope, Luis M; De La Sierra, Alejandro

    2013-02-01

    Resistant hypertension (RH) is frequently associated with a high prevalence of target organ damage, which impairs the prognosis of these patients. Considering cardiac alterations in RH, most attention has been devoted to left ventricular hypertrophy (LVH), but data concerning left atrial enlargement (LAE) is less known. This cross-sectional study assessed the factors associated with LAE, with special focus on blood pressure (BP) estimates obtained by ambulatory blood pressure monitoring (ABPM), in 250 patients with RH, aged 64 ± 11 years. LAE and LVH were observed in 10.0% (95% CI 6.3-13.7) and 57.1% (95% CI 50.8-63.5) of patients, respectively. Compared with patients with normal atrium size, those exhibiting LAE were older, more frequently women, had elevated pulse pressure (PP) measured both at the office and by ABPM, and showed higher prevalence of LVH (83% vs 54%; p = 0.016). In a logistic regression analysis, adjusting for age, gender, body mass index, left ventricular mass index and BP pressure estimates, night-time PP was independently associated with LAE (OR for 5 mmHg = 1.28, 95% CI 1.24-1.32; p = 0.001). In conclusion, besides classical determinants of LAE, such as age and LVH, an elevated night-time PP was independently associated with LAE in patients with RH.

  16. FILTER-INDUCED BIAS IN Lyα EMITTER SURVEYS: A COMPARISON BETWEEN STANDARD AND TUNABLE FILTERS. GRAN TELESCOPIO CANARIAS PRELIMINARY RESULTS

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    De Diego, J. A.; De Leo, M. A.; Cepa, J.

    Lyα emitter (LAE) surveys have successfully used the excess in a narrowband filter compared to a nearby broadband image to find candidates. However, the odd spectral energy distribution (SED) of LAEs combined with the instrumental profile has important effects on the properties of the candidate samples extracted from these surveys. We investigate the effect of the bandpass width and the transmission profile of the narrowband filters used for extracting LAE candidates at redshifts z ≅ 6.5 through Monte Carlo simulations, and we present pilot observations to test the performance of tunable filters to find LAEs and other emission-line candidates. Wemore » compare the samples obtained using a narrow ideal rectangular filter, the Subaru NB921 narrowband filter, and sweeping across a wavelength range using the ultra-narrow-band tunable filters of the instrument OSIRIS, installed at the 10.4 m Gran Telescopio Canarias. We use this instrument for extracting LAE candidates from a small set of real observations. Broadband data from the Subaru, Hubble Space Telescope, and Spitzer databases were used for fitting SEDs to calculate photometric redshifts and to identify interlopers. Narrowband surveys are very efficient in finding LAEs in large sky areas, but the samples obtained are not evenly distributed in redshift along the filter bandpass, and the number of LAEs with equivalent widths <60 Å can be underestimated. These biased results do not appear in samples obtained using ultra-narrow-band tunable filters. However, the field size of tunable filters is restricted because of the variation of the effective wavelength across the image. Thus, narrowband and ultra-narrow-band surveys are complementary strategies to investigate high-redshift LAEs.« less

  17. Preliminary investigations on the effects of a Strongylus vulgaris larval extract, mononuclear factors and platelet factors on equine smooth muscle cells in vitro.

    PubMed

    Morgan, S J; Storts, R W; Stromberg, P C; Sowa, B A; Lay, J C

    1989-01-01

    Factors involved in the proliferation of equine vascular smooth muscle cells were studied in vitro. The most prominent proliferative responses in cultured vascular smooth muscle cells were induced by Strongylus vulgaris larval antigen extract (LAE) and platelet-derived factors. Less significant proliferative responses were obtained with conditioned media from S. vulgaris LAE stimulated and from unstimulated equine mononuclear leukocytes. Additionally, vascular smooth muscle cells exposed to S. vulgaris LAE developed numerous perinuclear vacuoles and were more spindle-shaped than control or smooth muscle cells exposed to other factors. Equine mononuclear leukocytes exposed to LAE developed prominent morphological changes, including enlargement, clumping and increased numbers of mitotic figures.

  18. SILVERRUSH. V. Census of Lyα, [O III] λ5007, Hα, and [C II] 158 μm Line Emission with ∼1000 LAEs at z = 4.9–7.0 Revealed with Subaru/HSC

    NASA Astrophysics Data System (ADS)

    Harikane, Yuichi; Ouchi, Masami; Shibuya, Takatoshi; Kojima, Takashi; Zhang, Haibin; Itoh, Ryohei; Ono, Yoshiaki; Higuchi, Ryo; Inoue, Akio K.; Chevallard, Jacopo; Capak, Peter L.; Nagao, Tohru; Onodera, Masato; Faisst, Andreas L.; Martin, Crystal L.; Rauch, Michael; Bruzual, Gustavo A.; Charlot, Stephane; Davidzon, Iary; Fujimoto, Seiji; Hilmi, Miftahul; Ilbert, Olivier; Lee, Chien-Hsiu; Matsuoka, Yoshiki; Silverman, John D.; Toft, Sune

    2018-06-01

    We investigate Lyα, [O III] λ5007, Hα, and [C II] 158 μm emission from 1124 galaxies at z = 4.9–7.0. Our sample is composed of 1092 Lyα emitters (LAEs) at z = 4.9, 5.7, 6.6, and 7.0 identified by Subaru/Hyper-Suprime-Cam (HSC) narrowband surveys covered by Spitzer Large Area Survey with Hyper-Suprime-Cam (SPLASH) and 34 galaxies at z = 5.148–7.508 with deep ALMA [C II] 158 μm data in the literature. Fluxes of strong rest-frame optical lines of [O III] and Hα (Hβ) are constrained by significant excesses found in the SPLASH 3.6 and 4.5 μm photometry. At z = 4.9, we find that the rest-frame Hα equivalent width and the Lyα escape fraction f Lyα positively correlate with the rest-frame Lyα equivalent width {EW}}Lyα }0. The {f}Lyα }{--}{EW}}Lyα }0 correlation is similarly found at z ∼ 0–2, suggesting no evolution of the correlation over z ≃ 0–5. The typical ionizing photon production efficiency of LAEs is log(ξ ion/[Hz erg‑1]) ≃ 25.5, significantly (60%–100%) higher than those of LBGs at a given UV magnitude. At z = 5.7–7.0, there exists an interesting turnover trend that the [O III]/Hα flux ratio increases in {EW}}Lyα }0≃ 0{--}30 \\mathringA and then decreases out to {EW}}Lyα }0≃ 130 \\mathringA . We also identify an anticorrelation between a ratio of [C II] luminosity to star formation rate (L [C II]/SFR) and {EW}}Lyα }0 at the >99% confidence level.. We carefully investigate physical origins of the correlations with stellar-synthesis and photoionization models and find that a simple anticorrelation between {EW}}Lyα }0 and metallicity explains self-consistently all of the correlations of Lyα, Hα, [O III]/Hα, and [C II] identified in our study, indicating detections of metal-poor (∼0.03 Z ⊙) galaxies with {EW}}Lyα }0≃ 200 \\mathringA .

  19. On the UV compactness and morphologies of typical Lyman α emitters from z ˜ 2 to z ˜ 6

    NASA Astrophysics Data System (ADS)

    Paulino-Afonso, Ana; Sobral, David; Ribeiro, Bruno; Matthee, Jorryt; Santos, Sérgio; Calhau, João; Forshaw, Alex; Johnson, Andrea; Merrick, Joanna; Pérez, Sara; Sheldon, Oliver

    2018-06-01

    We investigate the rest-frame UV morphologies of a large sample of Lyman α emitters (LAEs) from z ˜ 2 to z ˜ 6, selected in a uniform way with 16 different narrow and medium bands over the full COSMOS field. We use 3045 LAEs with Hubble Space Telescope coverage in a stacking analysis and find that they have MUV ˜ -20, below M_UV^\\ast at these redshifts. We also focus our analysis on a subsample of 780 individual galaxies with iAB < 25 for which GALFIT converges for 429 of them. The individual median size (re ˜ 1 kpc), ellipticities [slightly elongated with (b/a) ˜ 0.45], Sérsic index (disc-like with n ≲ 2), and light concentration (comparable to that of disc or irregular galaxies, with C ˜ 2.7) of LAEs show mild evolution from z ˜ 2 to z ˜ 6. LAEs with the highest rest-frame equivalent widths (EWs) are the smallest/most compact (re ˜ 0.8 kpc, compared to re ˜ 1.5 kpc for the lower EW LAEs). When stacking our samples in bins of fixed Lyα luminosity and Lyα EW, we find evidence for redshift evolution in n and C, but not in galaxy sizes. The evolution seems to be stronger for LAEs with 25 < EW < 100 Å. When compared to other star-forming galaxies (SFGs), LAEs are found to be smaller at all redshifts. The difference between the two populations changes with redshift, from a factor of ˜1 at z ≳ 5 to SFGs being a factor of ˜2-4 larger than LAEs for z ≲ 2. This means that at the highest redshifts, where typical sizes approach those of LAEs, the fraction of galaxies showing Lyα in emission (and with a high Lyα escape fraction) should be much higher, consistent with observations.

  20. Left atrial enlargement increases the risk of major adverse cardiac events independent of coronary vasodilator capacity.

    PubMed

    Koh, Angela S; Murthy, Venkatesh L; Sitek, Arkadiusz; Gayed, Peter; Bruyere, John; Wu, Justina; Di Carli, Marcelo F; Dorbala, Sharmila

    2015-09-01

    Longstanding uncontrolled atherogenic risk factors may contribute to left atrial (LA) hypertension, LA enlargement (LAE) and coronary vascular dysfunction. Together they may better identify risk of major adverse cardiac events (MACE). The aim of this study was to test the hypothesis that chronic LA hypertension as assessed by LAE modifies the relationship between coronary vascular function and MACE. In 508 unselected subjects with a normal clinical (82)Rb PET/CT, ejection fraction ≥40 %, no prior coronary artery disease, valve disease or atrial fibrillation, LAE was determined based on LA volumes estimated from the hybrid perfusion and CT transmission scan images and indexed to body surface area. Absolute myocardial blood flow and global coronary flow reserve (CFR) were calculated. Subjects were systematically followed-up for the primary end-point - MACE - a composite of all-cause death, myocardial infarction, hospitalization for heart failure, stroke, coronary artery disease progression or revascularization. During a median follow-up of 862 days, 65 of the subjects experienced a composite event. Compared with subjects with normal LA size, subjects with LAE showed significantly lower CFR (2.25 ± 0.83 vs. 1.95 ± 0.80, p = 0.01). LAE independently and incrementally predicted MACE even after accounting for clinical risk factors, medication use, stress left ventricular ejection fraction, stress left ventricular end-diastolic volume index and CFR (chi-squared statistic increased from 30.9 to 48.3; p = 0.001). Among subjects with normal CFR, those with LAE had significantly worse event-free survival (risk adjusted HR 5.4, 95 % CI 2.3 - 12.8, p < 0.0001). LAE and reduced CFR are related but distinct cardiovascular adaptations to atherogenic risk factors. LAE is a risk marker for MACE independent of clinical factors and left ventricular volumes; individuals with LAE may be at risk of MACE despite normal coronary vascular function.

  1. Lyman-α emitters gone missing: the different evolution of the bright and faint populations

    NASA Astrophysics Data System (ADS)

    Weinberger, Lewis H.; Kulkarni, Girish; Haehnelt, Martin G.; Choudhury, Tirthankar Roy

    2018-06-01

    We model the transmission of the Lyman-α line through the circum- and intergalactic media around dark matter haloes expected to host Lyman-alpha emitters (LAEs) at z ≥ 5.7, using the high-dynamic-range Sherwood simulations. We find very different CGM environments around more massive haloes (˜1011M⊙) compared to less massive haloes (˜109M⊙) at these redshifts, which can contribute to a different evolution of the Lyα transmission from LAEs within these haloes. Additionally we confirm that part of the differential evolution could result from bright LAEs being more likely to reside in larger ionized regions. We conclude that a combination of the CGM environment and the IGM ionization structure is likely to be responsible for the differential evolution of the bright and faint ends of the LAE luminosity function at z ≥ 6. More generally, we confirm the suggestion that the self-shielded neutral gas in the outskirts of the host halo can strongly attenuate the Lyα emission from high redshift galaxies. We find that this has a stronger effect on the more massive haloes hosting brighter LAEs. The faint-end of the LAE luminosity function is thus a more reliable probe of the average ionization state of the IGM. Comparing our model for LAEs with a range of observational data we find that the favoured reionization histories are our previously advocated `Late' and `Very Late' reionization histories, in which reionization finishes rather rapidly at around z ≃ 6.

  2. Mineralization of Surfactants by Microbiota of Aquatic Plants.

    PubMed

    Federle, Thomas W; Schwab, Burney S

    1989-08-01

    The biodegradation of linear alkylbenzene sulfonate (LAS) and linear alcohol ethoxylate (LAE) by the microbiota associated with duckweed (Lemna minor) and the roots of cattail (Typha latifolia) was investigated. Plants were obtained from a pristine pond and a pond receiving wastewater from a rural laundromat. Cattail roots and duckweed plants were incubated in vessels containing sterile water amended with [C]LAS, [C]LAE, or C-labeled mixed amino acids (MAA). Evolution of CO(2) was determined over time. The microbiota of cattail roots from both ponds mineralized LAS, LAE, and MAA without lag periods, and the rates and extents of mineralization were not significantly affected by the source of the plants. Mineralization of LAS and LAE was more rapid in the rhizosphere than in nearby root-free sediments, which exhibited differences as a function of pond. The microbiota of duckweed readily mineralized LAE and MAA but not LAS. The rate and extent of mineralization were not affected by the source of the duckweed.

  3. Reduction of Salmonella in skinless chicken breast fillets by lauric arginate surface application.

    PubMed

    Sharma, C S; Ates, A; Joseph, P; Nannapaneni, R; Kiess, A

    2013-05-01

    Lauric arginate (LAE) has been found to be effective against various foodborne pathogens. In this study, the antimicrobial efficacy of LAE against Salmonella and mesophilic organisms was evaluated in fresh, skinless, boneless, uncooked chicken breast fillets. The effect of LAE treatments on pH and color of breast fillets was also assessed. Chicken breast fillets were inoculated with a 4-strain Salmonella cocktail (Salmonella Enteritidis ATCC 4931, Salmonella Heidelberg ATCC 8326, Salmonella Kentucky ATCC 9263, and Salmonella Typhimurium ATCC 14028) and then treated with sterile dionized water (positive control) and 200 ppm and 400 ppm of LAE. The chicken breast fillets were stored at 4 ± 1°C and analyzed on d 0, 1, 3, 5, and 7 for Salmonella, total aerobes, color, and pH. The fillets destined for color analysis were not inoculated with Salmonella cocktail and stored under conditions simulating the retail display. The fillets treated with 400 ppm LAE had lower (P < 0.05) Salmonella counts compared with the positive control from d 0 through d 7 of storage except on d 3, when no effect of LAE was observed. Treating fillets with 200 ppm of LAE caused a significant reduction in Salmonella counts (P < 0.1) on d 0, 1, and 7. Reductions in Salmonella spp. were 0.7 log cfu/g and 0.7 to 1.0 log cfu/g for 200 and 400 ppm treatments, respectively. Lauric arginate did not exhibit any treatment effect on the growth of mesophilic microorganisms, pH, and color of chicken breast fillets (P > 0.05) when applied at 200 and 400 ppm concentrations. These results indicate that surface application of LAE in chicken breast fillets significantly reduces Salmonella during refrigerated aerobic storage without negatively affecting the color of chicken breast fillets.

  4. A Study in Lyman-Alpha

    NASA Astrophysics Data System (ADS)

    Hagen, Alex

    This thesis concentrates on the physical and morphological properties of galaxies via image analysis and spectral energy distribution fitting. My research primarily focuses on Lyman-alpha emitting galaxies (LAEs) at z 2, but to place the investigations in context, comparison samples of galaxies are also used. These galaxies present the opportunity to study formation and evolution of low-mass galaxies at this redshift, which is extremely difficult using continuum selection methods. Chapter 1 gives an introduction to LAEs and puts them in the context of galaxy formation and evolution. Chapter 2 was originally published as Hagen et al. (2014), which studied the physical properties of LAEs at 1.9 < z < 3.5 from the HETDEX Pilot Survey (Adams et al. 2011; Blanc et al. 2011). This paper found that LAEs span almost a three dex range in stellar mass and could be simply drawn for the star-forming galaxy mass function. We also found that, while most LAEs are dust poor, there were some objects that weren't. The Lyman-alpha photons seem to experience the same dust opacity as the UV continuum, suggesting that in these galaxies Lyman-alpha does not undergo significant scattering before escaping. This result, when matched with radiative transfer simulations, will help to constrain how Lyman-alpha escapes galaxies. Chapter 3, originally published as Hagen et al. (2016), describes research that studies how Lyman-alpha emitters are drawn from star-forming galaxies. This work used galaxies identified via their optical emission lines (oELGs) as a comparison sample (Zeimann et al. 2015a). These oELGs have a mass range similar to LAEs and are an excellent comparison sample to LAEs. Previous comparison samples, such as LBGs, are two dex more massive than LAEs and thus do not represent galaxies in the same evolutionary state as LAEs. We compared ten physical and morphological properties between Lyman-alpha and non-Lyman-alpha emitting galaxies and found no statistically significant

  5. Evolution in the Continuum Morphological Properties of Ly alpha-Emitting Galaxies from Z=3.1 to Z=2.1

    NASA Technical Reports Server (NTRS)

    Bond, Nicholas A.; Gawiser, Eric; Guaita, Lucia; Padilla, Nelson; Gronwall, Chile Caryl; Ciardullo, Robin; Lai, Kamson

    2011-01-01

    We present a rest-frame ultraviolet morphological analysis of 108 z = 2.1 Lyman Alpha Emitters (LAEs) in the Extended Chandra Deep Field South (ECDF-S) and compare it to a similar sample of 171 LAEs at z = 3.1 . Using Hubble Space Telescope (HST) images taken as part of the Galaxy Evolution From Morphology and SEDs survey, Great Observatories Origins Deep Survey, and Hubble Ultradeep Field surveys, we measure the size and photometric component distributions, where photo- metric components are defined as distinct clumps of UV-continuum emission. At both redshifts, the majority of LAEs have observed half-light radii < 2 kpc, but the median half-light radius rises from 0.97 kpc at z = 3.1 to 1.41 kpc at z = 2.1. A similar evolution is seen in the sizes of individual rest-UV components, but there is no evidence for evolution in the number of mUlti-component systems. In the z = 2.1 LAE sample, we see clear correlations between the LAE size and other physical properties derived from its SED. LAEs are found to be larger for galaxies with larger stellar mass, larger star formation rate, and larger dust obscuration, but there is no evidence for a trend between equivalent width and half-light radius at either redshift. The presence of these correlations suggests that a wide range of objects are being selected by LAE surveys at that redshift, including a significant fraction of objects for which a massive and moderately extended population of old stars underlies the young starburst giving rise to the Lya emission.

  6. Mineralization of surfactants by microbiota of aquatic plants. [Lemna minor, Typha latifolia

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Federle, T.W.; Schwab, B.S.

    1989-08-01

    The biodegradation of linear alkylbenzene sulfonate (LAS) and linear alcohol ethoxylate (LAE) by the microbiota associated with duckweed (Lemna minor) and the roots of cattail (Typha latifolia) was investigated. Plants were obtained from a pristine pond and a pond receiving wastewater from a rural laundromat. Cattail roots and duckweed plants were incubated in vessels containing sterile water amended with ({sup 14}C)LAS, ({sup 14}C)LAE, or {sup 14}C-labeled mixed amino acids (MAA). Evolution of {sup 14}CO{sub 2} was determined over time. The microbiota of cattail roots from both ponds mineralized LAS, LAE, and MAA without lag periods, and the rates and extentsmore » of mineralization were not significantly affected by the source of the plants. Mineralization of LAS and LAE was more rapid in the rhizosphere than in nearby root-free sediments, which exhibited differences as a function of pond. The microbiota of duckweed readily mineralized LAE and MAA but not LAS. The rate and extent of mineralization were not affected by the source of the duckweed.« less

  7. Mineralization of Surfactants by Microbiota of Aquatic Plants

    PubMed Central

    Federle, Thomas W.; Schwab, Burney S.

    1989-01-01

    The biodegradation of linear alkylbenzene sulfonate (LAS) and linear alcohol ethoxylate (LAE) by the microbiota associated with duckweed (Lemna minor) and the roots of cattail (Typha latifolia) was investigated. Plants were obtained from a pristine pond and a pond receiving wastewater from a rural laundromat. Cattail roots and duckweed plants were incubated in vessels containing sterile water amended with [14C]LAS, [14C]LAE, or 14C-labeled mixed amino acids (MAA). Evolution of 14CO2 was determined over time. The microbiota of cattail roots from both ponds mineralized LAS, LAE, and MAA without lag periods, and the rates and extents of mineralization were not significantly affected by the source of the plants. Mineralization of LAS and LAE was more rapid in the rhizosphere than in nearby root-free sediments, which exhibited differences as a function of pond. The microbiota of duckweed readily mineralized LAE and MAA but not LAS. The rate and extent of mineralization were not affected by the source of the duckweed. PMID:16347999

  8. Spectroscopic properties of luminous Ly α emitters at z ≈ 6-7 and comparison to the Lyman-break population

    NASA Astrophysics Data System (ADS)

    Matthee, Jorryt; Sobral, David; Darvish, Behnam; Santos, Sérgio; Mobasher, Bahram; Paulino-Afonso, Ana; Röttgering, Huub; Alegre, Lara

    2017-11-01

    We present spectroscopic follow-up of candidate luminous Ly α emitters (LAEs) at z = 5.7-6.6 in the SA22 field with VLT/X-SHOOTER. We confirm two new luminous LAEs at z = 5.676 (SR6) and z = 6.532 (VR7), and also present HST follow-up of both sources. These sources have luminosities LLy α ≈ 3 × 1043 erg s-1, very high rest-frame equivalent widths of EW0 ≳ 200 Å and narrow Ly α lines (200-340 km s-1). VR7 is the most UV-luminous LAE at z > 6.5, with M1500 = -22.5, even brighter in the UV than CR7. Besides Ly α, we do not detect any other rest-frame UV lines in the spectra of SR6 and VR7, and argue that rest-frame UV lines are easier to observe in bright galaxies with low Ly α equivalent widths. We confirm that Ly α line widths increase with Ly α luminosity at z = 5.7, while there are indications that Ly α lines of faint LAEs become broader at z = 6.6, potentially due to reionization. We find a large spread of up to 3 dex in UV luminosity for >L⋆ LAEs, but find that the Ly α luminosity of the brightest LAEs is strongly related to UV luminosity at z = 6.6. Under basic assumptions, we find that several LAEs at z ≈ 6-7 have Ly α escape fractions ≳ 100 per cent, indicating bursty star formation histories, alternative Ly α production mechanisms, or dust attenuating Ly α emission differently than UV emission. Finally, we present a method to compute ξion, the production efficiency of ionizing photons, and find that LAEs at z ≈ 6-7 have high values of log10(ξion/Hz erg-1) ≈ 25.51 ± 0.09 that may alleviate the need for high Lyman-Continuum escape fractions required for reionization.

  9. Lyα emitters with very large Lyα equivalent widths, EW0(Lyα) ≃ 200-400 Å, at z ˜ 2

    NASA Astrophysics Data System (ADS)

    Hashimoto, Takuya; Ouchi, Masami; Shimasaku, Kazuhiro; Schaerer, Daniel; Nakajima, Kimihiko; Shibuya, Takatoshi; Ono, Yoshiaki; Rauch, Michael; Goto, Ryosuke

    2017-02-01

    We present physical properties of spectroscopically confirmed Lyα emitters (LAEs) with very large rest-frame Lyα equivalent widths EW0(Lyα). Although the definition of large EW0(Lyα) LAEs is usually difficult due to limited statistical and systematic uncertainties, we identify six LAEs selected from ˜3000 LAEs at z ˜ 2 with reliable measurements of EW0 (Lyα) ≃ 200-400 Å given by careful continuum determinations with our deep photometric and spectroscopic data. These large EW0(Lyα) LAEs do not have signatures of AGN, but notably small stellar masses of M★ = 107-8 M⊙ and high specific star formation rates (star formation rate per unit galaxy stellar mass) of ˜100 Gyr-1. These LAEs are characterized by the median values of L(Lyα) = 3.7 × 1042 erg s-1 and MUV = -18.0 as well as the blue UV continuum slope of β = -2.5 ± 0.2 and the low dust extinction E(B-V)_* = 0.02^{+0.04}_{-0.02}, which indicate a high median Lyα escape fraction of f_esc^{Lyα }=0.68± 0.30. This large f_esc^{Lyα } value is explained by the low H I column density in the interstellar medium which is consistent with full width at half-maximum (FWHM) of the Lyα line, FWHM(Lyα) = 212 ± 32 km s-1, significantly narrower than those of small EW0(Lyα) LAEs. Based on the stellar evolution models, our observational constraints of the large EW0 (Lyα), the small β, and the rest-frame He II EW imply that at least a half of our large EW0(Lyα) LAEs would have young stellar ages of ≲20 Myr and very low metallicities of Z < 0.02 Z⊙ regardless of the star formation history.

  10. First Spectroscopic Evidence for High Ionization State and Low Oxygen Abundance in Lyα Emitters

    NASA Astrophysics Data System (ADS)

    Nakajima, Kimihiko; Ouchi, Masami; Shimasaku, Kazuhiro; Hashimoto, Takuya; Ono, Yoshiaki; Lee, Janice C.

    2013-05-01

    We present results from Keck/NIRSPEC and Magellan/MMIRS follow-up spectroscopy of Lyα emitters (LAEs) at z = 2.2 identified in our Subaru narrowband survey. We successfully detect Hα emission from seven LAEs, and perform a detailed analysis of six LAEs free from active galactic nucleus activity, two out of which, CDFS-3865 and COSMOS-30679, have [O II] and [O III] line detections. They are the first [O II]-detected LAEs at high-z, and their [O III]/[O II] ratios and R23-indices provide the first simultaneous determinations of ionization parameter and oxygen abundance for LAEs. CDFS-3865 has a very high ionization parameter (q_{ion}=2.5^{+1.7}_{-0.8} \\times 10^8 cm s-1) and a low oxygen abundance (12+log (O/H)=7.84^{+0.24}_{-0.25}) in contrast with moderate values of other high-z galaxies such as Lyman break galaxies (LBGs). COSMOS-30679 also possesses a relatively high ionization parameter (q_{ion}=8^{+10}_{-4} \\times 10^7 cm s-1) and a low oxygen abundance (12+log (O/H)=8.18^{+0.28}_{-0.28}). Both LAEs appear to fall below the mass-metallicity relation of z ~ 2 LBGs. Similarly, a low metallicity of 12 + log (O/H) < 8.4 is independently indicated for typical LAEs from a composite spectrum and the [N II]/Hα index. Such high ionization parameters and low oxygen abundances can be found in local star-forming galaxies, but this extreme local population occupies only ~0.06% of the Sloan Digital Sky Survey spectroscopic galaxy sample with a number density ~100 times smaller than that of LAEs. With their high ionization parameters and low oxygen abundances, LAEs would represent an early stage of galaxy formation dominated by massive stars in compact star-forming regions. High-q ion galaxies like LAEs would produce ionizing photons efficiently with a high escape fraction achieved by density-bounded H II regions, which would significantly contribute to cosmic reionization at z > 6. Some of the data presented herein were obtained at the W. M. Keck Observatory, which is

  11. SILVERRUSH. VI. A simulation of Lyα emitters in the reionization epoch and a comparison with Subaru Hyper Suprime-Cam survey early data

    NASA Astrophysics Data System (ADS)

    Inoue, Akio K.; Hasegawa, Kenji; Ishiyama, Tomoaki; Yajima, Hidenobu; Shimizu, Ikkoh; Umemura, Masayuki; Konno, Akira; Harikane, Yuichi; Shibuya, Takatoshi; Ouchi, Masami; Shimasaku, Kazuhiro; Ono, Yoshiaki; Kusakabe, Haruka; Higuchi, Ryo; Lee, Chien-Hsiu

    2018-06-01

    The survey of Lyman α emitters (LAEs) with the Subaru Hyper Suprime-Cam, called SILVERRUSH (Ouchi et al. 2018, PASJ, 70, S13), is producing massive data of LAEs at z ≳ 6. Here we present LAE simulations to compare the SILVERRUSH data. In 1623 comoving Mpc3 boxes, where numerical radiative transfer calculations of reionization were performed, LAEs have been modeled with physically motivated analytic recipes as a function of halo mass. We have examined 23 models depending on the presence or absence of dispersion of halo Lyα emissivity, dispersion of the halo Lyα optical depth, τα, and halo mass dependence of τα. The unique free parameter in our model, a pivot value of τα, is calibrated so as to reproduce the z = 5.7 Lyα luminosity function (LF) of SILVERRUSH. We compare our model predictions with Lyα LFs at z = 6.6 and 7.3, LAE angular auto-correlation functions (ACFs) at z = 5.7 and 6.6, and LAE fractions in Lyman break galaxies at 5 < z < 7. The Lyα LFs and ACFs are reproduced by multiple models, but the LAE fraction turns out to be the most critical test. The dispersion of τα and the halo mass dependence of τα are essential to explain all observations reasonably. Therefore, a simple model of one-to-one correspondence between halo mass and Lyα luminosity with a constant Lyα escape fraction has been ruled out. Based on our best model, we present a formula to estimate the intergalactic neutral hydrogen fraction, x_{H I}, from the observed Lyα luminosity density at z ≳ 6. We finally obtain x_{H I}=0.5_{-0.3}^{+0.1} as a volume-average at z = 7.3.

  12. SILVERRUSH. VI. A simulation of Lyα emitters in the reionization epoch and a comparison with Subaru Hyper Suprime-Cam survey early data

    NASA Astrophysics Data System (ADS)

    Inoue, Akio K.; Hasegawa, Kenji; Ishiyama, Tomoaki; Yajima, Hidenobu; Shimizu, Ikkoh; Umemura, Masayuki; Konno, Akira; Harikane, Yuichi; Shibuya, Takatoshi; Ouchi, Masami; Shimasaku, Kazuhiro; Ono, Yoshiaki; Kusakabe, Haruka; Higuchi, Ryo; Lee, Chien-Hsiu

    2018-05-01

    The survey of Lyman α emitters (LAEs) with the Subaru Hyper Suprime-Cam, called SILVERRUSH (Ouchi et al. 2018, PASJ, 70, S13), is producing massive data of LAEs at z ≳ 6. Here we present LAE simulations to compare the SILVERRUSH data. In 1623 comoving Mpc3 boxes, where numerical radiative transfer calculations of reionization were performed, LAEs have been modeled with physically motivated analytic recipes as a function of halo mass. We have examined 23 models depending on the presence or absence of dispersion of halo Lyα emissivity, dispersion of the halo Lyα optical depth, τα, and halo mass dependence of τα. The unique free parameter in our model, a pivot value of τα, is calibrated so as to reproduce the z = 5.7 Lyα luminosity function (LF) of SILVERRUSH. We compare our model predictions with Lyα LFs at z = 6.6 and 7.3, LAE angular auto-correlation functions (ACFs) at z = 5.7 and 6.6, and LAE fractions in Lyman break galaxies at 5 < z < 7. The Lyα LFs and ACFs are reproduced by multiple models, but the LAE fraction turns out to be the most critical test. The dispersion of τα and the halo mass dependence of τα are essential to explain all observations reasonably. Therefore, a simple model of one-to-one correspondence between halo mass and Lyα luminosity with a constant Lyα escape fraction has been ruled out. Based on our best model, we present a formula to estimate the intergalactic neutral hydrogen fraction, x_{H I}, from the observed Lyα luminosity density at z ≳ 6. We finally obtain x_{H I}=0.5_{-0.3}^{+0.1} as a volume-average at z = 7.3.

  13. The Evolution of Ly-alpha Emitting Galaxies Between z = 2.1 and z = 3.l

    NASA Technical Reports Server (NTRS)

    Ciardullo, Robin; Gronwall,Caryl; Wolf, Christopher; McCathran, Emily; Bond, Nicholas A.; Gawiser, Eric; Guaita, Lucia; Feldmeier, John J.; Treister, Ezequiel; Padilla, Nelson; hide

    2011-01-01

    We describe the results of a new, wide-field survey for z= 3.1 Ly-alpha emission-line galaxies (LAEs) in the Extended Chandra Deep Field South (ECDF-S). By using a nearly top-hat 5010 Angstrom filter and complementary broadband photometry from the MUSYC survey, we identify a complete sample of 141 objects with monochromatic fluxes brighter than 2.4E-17 ergs/cm^2/s and observers-frame equivalent widths greater than 80 Angstroms (i.e., 20 Angstroms in the rest-frame of Ly-alpha). The bright-end of this dataset is dominated by x-ray sources and foreground objects with GALEX detections, but when these interlopers are removed, we are still left with a sample of 130 LAE candidates, 39 of which have spectroscopic confirmations. This sample overlaps the set of objects found in an earlier ECDF-S survey, but due to our filter's redder bandpass, it also includes 68 previously uncataloged sources. We confirm earlier measurements of the z=3.1 LAE emission-line luminosity function, and show that an apparent anti-correlation between equivalent width and continuum brightness is likely due to the effect of correlated errors in our heteroskedastic dataset. Finally, we compare the properties of z=3.1 LAEs to LAEs found at z=2.1. We show that in the approximately 1 Gyr after z approximately 3, the LAE luminosity function evolved significantly, with L * fading by approximately 0.4 mag, the number density of sources with L greater than 1.5E42 ergs/s declining by approximately 50%, and the equivalent width scalelength contracting from 70^{+7}_{-5} Angstroms to 50^{+9}_{-6} Angstroms. When combined with literature results, our observations demonstrate that over the redshift range z approximately 0 to z approximately 4, LAEs contain less than approximately 10% of the star-formation rate density of the universe.

  14. Discovery of a Protocluster Associated with a Lyα Blob Pair at z = 2.3

    NASA Astrophysics Data System (ADS)

    Bădescu, Toma; Yang, Yujin; Bertoldi, Frank; Zabludoff, Ann; Karim, Alexander; Magnelli, Benjamin

    2017-08-01

    Bright Lyα blobs (LABs)—extended nebulae with sizes of ˜100 kpc and Lyα luminosities of ˜1044 erg s-1—often reside in overdensities of compact Lyα emitters (LAEs) that may be galaxy protoclusters. The number density, variance, and internal kinematics of LABs suggest that they themselves trace group-like halos. Here, we test this hierarchical picture, presenting deep, wide-field Lyα narrowband imaging of a 1° × 0.°5 region around a LAB pair at z = 2.3 discovered previously by a blind survey. We find 183 Lyα emitters, including the original LAB pair and three new LABs with Lyα luminosities of (0.9{--}1.3)× {10}43 erg s-1 and isophotal areas of 16-24 arcsec2. Using the LAEs as tracers and a new kernel density estimation method, we discover a large-scale overdensity (Boötes J1430+3522) with a surface density contrast of {δ }{{Σ }}=2.7, a volume density contrast of δ ˜10.4, and a projected diameter of ≈20 comoving Mpc. Comparing with cosmological simulations, we conclude that this LAE overdensity will evolve into a present-day Coma-like cluster with {log}(M/{M}⊙ ) ˜ 15.1 ± 0.2. In this and three other wide-field LAE surveys re-analyzed here, the extents and peak amplitudes of the largest LAE overdensities are similar, not increasing with survey size, and implying that they were indeed the largest structures then and today evolve into rich clusters. Intriguingly, LABs favor the outskirts of the densest LAE concentrations, I.e., intermediate LAE overdensities of {δ }{{Σ }}=1{--}2. We speculate that these LABs mark infalling protogroups being accreted by the more massive protocluster.

  15. Responses of a submersed aquatic plant and periphyton to a nonionic surfactant in model stream mesocosm exposures

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Dunn, A.W.; Rodgers, J.H. Jr.; Dorn, P.B.

    The effects of a nonionic linear alcohol ethoxylate (LAE) surfactant (with an average of 12.8 carbons per chain length and an average of 7.0 ethylene oxide units/mole) on Myriophyllum aquaticum L. and periphyton were evaluated in 30 day exposures in twelve model stream mesocosms. Effects evaluated included: chlorophyll a, pheophytin a, biomass, and membrane integrity for M. aquaticum, and chlorophyll a, pheophytin a, and biomass for periphyton. Average measured concentrations of LAE for replicate streams were 0.32, 0.88, 1.98, and 5.2 mg LAE/L with two untreated controls. During the 30 days exposure in the model stream mesocosms, no significant differencesmore » were observed among treatments and controls, and the estimated LOEC and NOEC for M. aquaticum and periphyton for all parameters measured was > 5.2 mg LAE/L. Based on the results of this study, M. aquaticum and periphyton were relatively insensitive to this (LAE) surfactant when compared with effects observed on fish and macroinvertebrates. These results are similar to those obtained in two previous experimental stream studies with other AE homologs.« less

  16. The Origin of Low Altitude ENA Emissions from Storms in 2000-2005 as Observed by IMAGE/MENA

    NASA Astrophysics Data System (ADS)

    Perez, J. D.; Sheehan, M. M.; Jahn, J.; Mackler, D.; Pollock, C. J.

    2013-12-01

    Low Altitude Emissions (LAEs) are prevalent features of Energetic Neutral Atom (ENA) images of the inner magnetosphere. It is believed that they are created by precipitating ions that reach altitudes near 500 km and then charge exchange with oxygen atoms, subsequently escaping to be observed by satellite borne ENA imagers. In this study, LAEs from the MENA instrument onboard the IMAGE satellite are studied in order to learn about the origin of the precipitating ions. Using the Tsyganenko 05 magnetic field model, the bright pixels capturing the LAEs are mapped to the equator. The LAEs are believed to originate from ions near their mirroring point, i.e., with pitch angles near 90o. Therefore the angle between the line-of-sight and the magnetic field at the point of origin is used to further constrain possible magnetospheric regions that are the origin of the ENAs. By observing the time dependence of the strength and location of the LAEs during geomagnetic storms in the years 2000-2005, the dynamics of the emptying and filling of the loss cone by injected particles is observed. Thus, information regarding the coupling between the inner magnetosphere and the ionosphere is obtained.

  17. System and method for interfacing large-area electronics with integrated circuit devices

    DOEpatents

    Verma, Naveen; Glisic, Branko; Sturm, James; Wagner, Sigurd

    2016-07-12

    A system and method for interfacing large-area electronics with integrated circuit devices is provided. The system may be implemented in an electronic device including a large area electronic (LAE) device disposed on a substrate. An integrated circuit IC is disposed on the substrate. A non-contact interface is disposed on the substrate and coupled between the LAE device and the IC. The non-contact interface is configured to provide at least one of a data acquisition path or control path between the LAE device and the IC.

  18. Large Aquatic Ecosystem Restoration Monitoring for Decision Makers: Monitoring to Target and Evaluate Success of Ecosystem Restoration

    EPA Science Inventory

    Monitoring ecosystem restoration at various scales in LAEs can be challenging, frustrating and rewarding. Some of the major ecosystem restoration monitoring occurring in LAEs include: seagrass expansion/contraction; dead zone sizes; oyster reefs; sea turtle nesting; toxic and nu...

  19. Measuring the Stellar Populations of Individual Lyman Alpha Emitters During the Epoch of Peak Star Formation

    NASA Astrophysics Data System (ADS)

    Reddy, Naveen

    2010-09-01

    Selecting galaxies by their strong Lyman-alpha emission provides a powerful means of probing the reionization epoch and the faint/low-mass galaxies that dominate star formation at high redshift. Yet, our understanding of high-redshift Lyman-alpha emitters {LAEs} has lagged behind that of other well-studied populations {e.g., Lyman break galaxies} due to their continuum faintness and the shifting of age/mass-sensitive features into the near-IR where the high terrestrial background inhibits deep observations. All existing studies of LAEs at z>2 have used stacked optical and/or Spitzer infrared data to discern their median properties, but the actual distributions of ages, reddenings, and stellar masses for these populations are poorly characterized. To fill this glaring gap in the observations and advance our understanding of this important population, we propose WFC3/IR+F160W imaging of fields where we have conducted a survey of low redshift {z 1.9} Lyman-alpha emitters {LAEs}, in order to measure their ages and stellar masses at an epoch where such observations directly probe the age-sensitive Balmer/4000 AA breaks. The targeted sample will include 45-50 spectroscopically confirmed LAEs at z=1.7-2.1 and roughly twice as many candidates, making it the largest sample of homogeneously selected LAEs with individual measurements of the ages, masses, and dust extinction. With these data we will {1} carefully take into account the age-dependence of the extinction curve to make robust comparisons between LAEs and continuum-selected galaxies at the same redshifts; {2} combine clustering and stellar mass measurements to infer the duty cycles of LAEs and determine if they are triggered in the presence of large-scale structures; and {3} quantify the importance of the LAE phase at different galaxy luminosity and mass scales, over a large dynamic range in these properties. An economical investment of just 12 orbits will allow us to accomplish these goals, and remains the only

  20. Survey parameters for detecting 21cm - Lyα emitter cross correlations with the Square Kilometre Array

    NASA Astrophysics Data System (ADS)

    Hutter, Anne; Trott, Cathryn M.; Dayal, Pratika

    2018-06-01

    Detections of the cross correlation signal between the 21cm signal during reionization and high-redshift Lyman Alpha emitters (LAEs) are subject to observational uncertainties which mainly include systematics associated with radio interferometers and LAE selection. These uncertainties can be reduced by increasing the survey volume and/or the survey luminosity limit, i.e. the faintest detectable Lyman Alpha (Lyα) luminosity. We use our model of high-redshift LAEs and the underlying reionization state to compute the uncertainties of the 21cm-LAE cross correlation function at z ≃ 6.6 for observations with SKA1-Low and LAE surveys with Δz = 0.1 for three different values of the average IGM ionization state (⟨χHI⟩≃ 0.1, 0.25, 0.5). At z ≃ 6.6, we find SILVERRUSH type surveys, with a field of view of 21 deg2 and survey luminosity limits of Lα ≥ 7.9 × 1042erg s-1, to be optimal to distinguish between an inter-galactic medium (IGM) that is 50%, 25% and 10% neutral, while surveys with smaller fields of view and lower survey luminosity limits, such as the 5 and 10 deg2 surveys with WFIRST, can only discriminate between a 50% and 10% neutral IGM.

  1. Evolution of Lyman-α Emitters, Lyman-break Galaxies and Elliptical Galaxies

    NASA Astrophysics Data System (ADS)

    Mori, M.; Umemura, M.

    2008-10-01

    High redshift Lyman-α emitters (LAEs) and Lyman-break galaxies (LBGs) possibly provide a significant key for the embryology of galaxies. LBGs have been argued as candidate progenitors of present-day elliptical galaxies in terms of their observed properties. But, what evolutionary stages LBGs correspond to and how they are related to LAEs are still under debate. Here, we present an ultra-high-resolution hydrodynamic simulation of galaxy formation. We show that, at the earliest stages of less than 3×10^8 years, continual supernova explosions produce multitudinous hot bubbles and cooled HI shells in between. The HI shells radiate intense Lyman-α emission like LAEs. We found that the bubbly structures produced are quite similar to the observed features in the Lyman-α surface brightness distribution of the extended LAEs. After 10^9 years, the galaxy emission is dominated by stellar continuum, exhibiting an LBG-like spectrum. Also, we find that, as a result of purely dynamical evolution over 13 billion years, the properties of this galaxy match those of present-day elliptical galaxies well. It is implied that the major episode of star formation and chemical enrichment in elliptical galaxies is almost completed in the evolutionary path from LAEs to LBGs.

  2. Spectral Energy Distribution Fitting of Hetdex Pilot Survey Ly-alpha Emitters in Cosmos and Goods-N

    NASA Technical Reports Server (NTRS)

    Hagen, Alex; Ciardullo, Robin; Cronwall, Caryl; Acquaviva, Viviana; Bridge, Joanna; Zeimann, Gregory R.; Blanc, Guillermo; Bond, Nicholas; Finkelstein, Steven L.; Song, Mimi; hide

    2014-01-01

    We use broadband photometry extending from the rest-frame UV to the near-IR to fit the individual spectral energy distributions of 63 bright (L(Ly-alpha) greater than 10(exp 43) erg s(exp -1) Ly-alpha emitting galaxies (LAEs) in the redshift range 1.9 less than z less than 3.6. We find that these LAEs are quite heterogeneous, with stellar masses that span over three orders of magnitude, from 7.5 greater than logM/solar mass less than 10.5. Moreover, although most LAEs have small amounts of extinction, some high-mass objects have stellar reddenings as large as E(B - V ) is approximately 0.4. Interestingly, in dusty objects the optical depths for Ly-alpha and the UV continuum are always similar, indicating that Lya photons are not undergoing many scatters before escaping their galaxy. In contrast, the ratio of optical depths in low-reddening systems can vary widely, illustrating the diverse nature of the systems. Finally, we show that in the star-formation-rate-log-mass diagram, our LAEs fall above the "main-sequence" defined by z is approximately 3 continuum selected star-forming galaxies. In this respect, they are similar to submillimeter-selected galaxies, although most LAEs have much lower mass.

  3. Reconstructing Ion Spectra from Low-Altitude ENAs: Moderate to Large Storms.

    NASA Astrophysics Data System (ADS)

    LLera, K.; Goldstein, J.; McComas, D. J.; Valek, P. W.

    2015-12-01

    Two Wide-angle Imaging Neutral-atom Spectrometers (TWINS) Energetic neutral atom (ENA) imagers regularly observe Low-altitude Emission (LAE) intensifications during geomagnetic storm intervals. Since LAEs are produced by the interaction between ions and the near-Earth exosphere (altitudes ~200-800 km), they are a global signature of how the ring current decays in response to solar wind conditions. In this "optically thick" region, an ENA readily becomes reionized, and an ion is readily neutralized. Therefore, emerging ENAs that contribute to the LAE signal (detectable several RE away) have undergone multiple charge exchange and electron stripping interactions. Accounting for the ~36 eV energy loss per interaction, we developed a model to quantify the total energy lost by emergent LAEs. The analytical tool is applied to an ensemble of moderate to large storms (including the recent 17 March and 23 June storms in 2015) to reconstruct the parent ion spectra from TWINS ENA images. We examine the ion spectra energy characteristics among the various storm events.

  4. Can Gas Outflows Explain The Strong Lyα Emission Of Lyman Alpha Emitters?

    NASA Astrophysics Data System (ADS)

    Hashimoto, Takuya; Ouchi, M.; Shimasaku, K.; Nakajima, K.; Ono, Y.; Rauch, M.

    2012-05-01

    Lyman alpha emitters (LAEs) are galaxies commonly seen at high redshift, probably playing an important role in galaxy evolution as building blocks of massive galaxies. The most interesting feature of LAEs is strong Lyα emission, because Lyα photons produced in a galaxy are expected to be easily absorbed by dust in the ISM before escaping the galaxy due to their resonant nature. Previous studies have suggested that outflow may help their escape thanks to reduced cross sections of outflowing (ie, redshifted) neutral hydrogen atoms. Although the presence of outflows can be examined from the offset of the Lyα emission from the systemic velocity defined by Hα emission, there are only four LAEs with reliable detection of Hα emission. We present the results of Magellan/MMIRS and Keck/NIRSPEC spectroscopic observations of five LAEs at z˜2.2 from our wide-field narrow-band survey with Subaru/Suprime-Cam. We successfully detect Hα emission for five objects. After eliminating an AGN contaminated object, we measure the velocityoffset between Lyα and Hα (Δ v_Lyα) for the remaining four, to find that three have a positive offset, suggesting an outflow. Since three among the four from the the literature also have an outflow, we conclude that ˜75% of LAEs have an outflow, with velocities of 75-280 km/s. We then use these eight LAEs to examine how the Lyα strength defined by Lyα escape fraction (f_esc) and/or Lyα equivalent width (EW(Lyα)) depend on other physical quantities including those derived from SED fitting. Contrary to our expectation, we find that both f_esc and EW(Lyα) decrease with Δ v_Lyα. Thus, although LAEs do have outflow, high outflow velocities are not the primary cause of strong Lyα emission. We also find that the Lyα strength does not depend on E(B-V). However, we find that objects with a clumpier gas distribution may have higher f_esc.

  5. GAS MOTION STUDY OF Ly{alpha} EMITTERS AT z {approx} 2 USING FUV AND OPTICAL SPECTRAL LINES {sup ,}

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Hashimoto, Takuya; Shimasaku, Kazuhiro; Nakajima, Kimihiko

    2013-03-01

    We present the results of Magellan/MMIRS and Keck/NIRSPEC spectroscopy for five Ly{alpha} emitters (LAEs) at z {approx_equal} 2.2 for which high-resolution FUV spectra from Magellan/MagE are available. We detect nebular emission lines including H{alpha} on the individual basis and low-ionization interstellar (LIS) absorption lines in a stacked FUV spectrum, and measure average offset velocities of the Ly{alpha} line, {Delta}v {sub Ly{alpha}}, and LIS absorption lines, {Delta}v {sub abs}, with respect to the systemic velocity defined by the nebular lines. For a sample of eight z {approx} 2-3 LAEs without active galactic nucleus from our study and the literature, we obtainmore » {Delta}v {sub Ly{alpha}} = 175 {+-} 35 km s{sup -1}, which is significantly smaller than that of Lyman-break Galaxies (LBGs), {Delta}v {sub Ly{alpha}} {approx_equal} 400 km s{sup -1}. The stacked FUV spectrum gives {Delta}v {sub abs} = -179 {+-} 73 km s{sup -1}, comparable to that of LBGs. These positive {Delta}v {sub Ly{alpha}} and negative {Delta}v {sub abs} suggest that LAEs also have outflows. In contrast to LBGs, however, the LAEs' {Delta}v {sub Ly{alpha}} is as small as |{Delta}v {sub abs}|, suggesting low neutral hydrogen column densities. Such a low column density with a small number of resonant scattering may cause the observed strong Ly{alpha} emission of LAEs. We find an anti-correlation between Ly{alpha} equivalent width (EW) and {Delta}v {sub Ly{alpha}} in a compilation of LAE and LBG samples. Although its physical origin is not clear, this anti-correlation result appears to challenge the hypothesis that a strong outflow, by means of a reduced number of resonant scattering, produces a large EW. If LAEs at z > 6 have similarly small {Delta}v {sub Ly{alpha}} values, constraints on the reionization history derived from the Ly{alpha} transmissivity may need to be revised.« less

  6. SILVERRUSH. III. Deep optical and near-infrared spectroscopy for Lyα and UV-nebular lines of bright Lyα emitters at z = 6-7

    NASA Astrophysics Data System (ADS)

    Shibuya, Takatoshi; Ouchi, Masami; Harikane, Yuichi; Rauch, Michael; Ono, Yoshiaki; Mukae, Shiro; Higuchi, Ryo; Kojima, Takashi; Yuma, Suraphong; Lee, Chien-Hsiu; Furusawa, Hisanori; Konno, Akira; Martin, Crystal L.; Shimasaku, Kazuhiro; Taniguchi, Yoshiaki; Kobayashi, Masakazu A. R.; Kajisawa, Masaru; Nagao, Tohru; Goto, Tomotsugu; Kashikawa, Nobunari; Komiyama, Yutaka; Kusakabe, Haruka; Momose, Rieko; Nakajima, Kimihiko; Tanaka, Masayuki; Wang, Shiang-Yu

    2018-01-01

    We present Lyα and UV-nebular emission line properties of bright Lyα emitters (LAEs) at z = 6-7 with a luminosity of log LLyα/[erg s-1] = 43-44 identified in the 21 deg2 area of the SILVERRUSH early sample developed with the Subaru Hyper Suprime-Cam survey data. Our optical spectroscopy newly confirms 21 bright LAEs with clear Lyα emission, and contributes to making a spectroscopic sample of 96 LAEs at z = 6-7 in SILVERRUSH. From the spectroscopic sample, we select seven remarkable LAEs as bright as Himiko and CR7 objects, and perform deep Keck/MOSFIRE and Subaru/nuMOIRCS near-infrared spectroscopy reaching the 3 σ flux limit of ˜2 × 10-18 erg s-1 for the UV-nebular emission lines of He II λ1640, C IV λλ1548,1550, and O III]λλ1661,1666. Except for one tentative detection of C IV, we find no strong UV-nebular lines down to the flux limit, placing the upper limits of the rest-frame equivalent widths (EW0) of ˜2-4 Å for C IV, He II, and O III] lines. We also investigate the VLT/X-SHOOTER spectrum of CR7 whose 6 σ detection of He II is claimed by Sobral et al. Although two individuals and the ESO archive service carefully reanalyzed the X-SHOOTER data that are used in the study of Sobral et al., no He II signal of CR7 is detected, supportive of weak UV-nebular lines of the bright LAEs even for CR7. The spectral properties of these bright LAEs are thus clearly different from those of faint dropouts at z ˜ 7 that have strong UV-nebular lines shown in the various studies. Comparing these bright LAEs and the faint dropouts, we find anti-correlations between the UV-nebular line EW0 and the UV-continuum luminosity, which are similar to those found at z ˜ 2-3.

  7. Using the Learners-as-Ethnographers Approach to Enhance Intercultural Learning among American College Students Learning Chinese as a Foreign Language

    ERIC Educational Resources Information Center

    Lu, Minhui

    2012-01-01

    This study explored how the learners-as-ethnographers (LAE) approach facilitated intercultural learning among American students learning Chinese as a foreign language. Two research questions addressed the effectiveness of the LAE approach and students' learning experiences in a non-immersion context. I designed six ethnographic tasks for the…

  8. Behavior of Listeria monocytogenes on frankfurters surface treated with lauric arginate and/or a liquid smoke extract delivered using the Sprayed Lethality in Container (SLIC®) technology

    USDA-ARS?s Scientific Manuscript database

    The objective of this study was to determine the viability of Listeria monocytogenes (LM) on commercially-produced frankfurters prepared without lactates that were surface treated with 0 or 4 mL of a blend of LAE (CytoGuard; 1.0% LAE final concentration) diluted in a concentrated liquid smoke extrac...

  9. Effects of Opsonization and Gamma Interferon on Growth of Brucella Melitensis 16M in Mouse Peritoneal Macrophages In Vitro

    DTIC Science & Technology

    2000-01-01

    bacterial CFU (Fig. 3). Macrophages cultured without brucel - lae or cultured with brucellae but without IFN-7 made ɘ.3 nmol of nitrite/200 JJLI well...receptors used for the uptake of nonopsonized brucel - lae are unknown. Synergy between the receptor for the Fc domain of immunoglobulin G (FcR) and

  10. No Ly α emitters detected around a QSO at z = 6.4: Suppressed by the QSO?★

    NASA Astrophysics Data System (ADS)

    Goto, Tomotsugu; Utsumi, Yousuke; Kikuta, Satoshi; Miyazaki, Satoshi; Shiki, Kensei; Hashimoto, Tetsuya

    2017-09-01

    Understanding how quasars' (QSOs') ultraviolet (UV) radiation affects galaxy formation is vital to our understanding of the reionization era. Using a custom-made narrow-band filter, NB906, on Subaru/Suprime-Cam, we investigated the number density of Ly α emitters (LAEs) around a QSO at z = 6.4. To date, this is the highest redshift narrow-band observation, where LAEs around a luminous QSO are investigated. Due to the large field of view of Suprime-Cam, our survey area is ˜5400 cMpc2, much larger than previous studies at z = 5.7 (˜200 cMpc2). In this field, we previously found a factor of 7 overdensity of Lyman break galaxies. Based on this, we expected to detect ˜100 LAEs down to NB906 = 25 ABmag. However, our 6.4 h exposure found none. The obtained upper limit on the number density of LAEs is more than an order lower than the blank fields. Furthermore, this lower density of LAEs spans a large scale of 10 pMpc across. A simple argument suggests that a strong UV radiation from the QSO can suppress star formation in haloes with Mvir < 1010 M⊙ within a pMpc from the QSO, but the deficit at the edge of the field (5 pMpc) remains to be explained.

  11. First Spectroscopic Confirmations of z ∼ 7.0 Ly α Emitting Galaxies in the LAGER Survey

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Hu, Weida; Wang, Junxian; Kang, Wenyong

    Narrowband imaging is a highly successful approach for finding large numbers of high-redshift Ly α emitting galaxies (LAEs) up to z ∼ 6.6. However, at z ≳ 7 there are as of yet only three narrowband selected LAEs with spectroscopic confirmations (two at z ∼ 6.9–7.0, one at z ∼ 7.3), which hinders extensive studies on cosmic reionization and galaxy evolution at this key epoch. We have selected 23 candidate z ∼ 6.9 LAEs in COSMOS field with the large area narrowband survey Lyman-Alpha Galaxies at the End of Reionization (LAGER). In this work, we present spectroscopic follow-up observations ofmore » 12 candidates using the Inamori Magellan Areal Camera and Spectrograph on Magellan. For nine of these, the observations are sufficiently deep to detect the expected lines. Ly α emission lines are identified in six sources (yielding a success rate of 2/3), including three luminous LAEs with Ly α luminosities of L {sub Lyα} ∼ 10{sup 43.5} erg s{sup −1}, the highest among known spectroscopically confirmed galaxies at ≳7.0. This triples the sample size of spectroscopically confirmed narrowband selected LAEs at z ≳ 7, and confirms the bright-end bump in the Ly α luminosity function we previously derived based on the photometric sample, supporting a patchy reionization scenario. Two luminous LAEs appear physically linked with a projected distance of 1.1 pMpc and velocity difference of ∼170 km s{sup −1}. They likely sit in a common ionized bubble produced by themselves or with close neighbors, which reduces the intergalactic medium attenuation of Ly α . A tentative narrow N v λ 1240 line is seen in one source, hinting at activity of a central massive black hole with metal-rich line-emitting gas.« less

  12. Interplay Between Genetic Substrate, QTc Duration, and Arrhythmia Risk in Patients With Long QT Syndrome.

    PubMed

    Mazzanti, Andrea; Maragna, Riccardo; Vacanti, Gaetano; Monteforte, Nicola; Bloise, Raffaella; Marino, Maira; Braghieri, Lorenzo; Gambelli, Patrick; Memmi, Mirella; Pagan, Eleonora; Morini, Massimo; Malovini, Alberto; Ortiz, Martin; Sacilotto, Luciana; Bellazzi, Riccardo; Monserrat, Lorenzo; Napolitano, Carlo; Bagnardi, Vincenzo; Priori, Silvia G

    2018-04-17

    Long QT syndrome (LQTS) is a common inheritable arrhythmogenic disorder, often secondary to mutations in the KCNQ1, KCNH2, and SCN5A genes. The disease is characterized by a prolonged ventricular repolarization (QTc interval) that confers susceptibility to life-threatening arrhythmic events (LAEs). This study sought to create an evidence-based risk stratification scheme to personalize the quantification of the arrhythmic risk in patients with LQTS. Data from 1,710 patients with LQTS followed up for a median of 7.1 years (interquartile range [IQR]: 2.7 to 13.4 years) were analyzed to estimate the 5-year risk of LAEs based on QTc duration and genotype and to assess the antiarrhythmic efficacy of beta-blockers. The relationship between QTc duration and risk of events was investigated by comparison of linear and cubic spline models, and the linear model provided the best fit. The 5-year risk of LAEs while patients were off therapy was then calculated in a multivariable Cox model with QTc and genotype considered as independent factors. The estimated risk of LAEs increased by 15% for every 10-ms increment of QTc duration for all genotypes. Intergenotype comparison showed that the risk for patients with LQT2 and LQT3 increased by 130% and 157% at any QTc duration versus patients with LQT1. Analysis of response to beta-blockers showed that only nadolol reduced the arrhythmic risk in all genotypes significantly compared with no therapy (hazard ratio: 0.38; 95% confidence interval: 0.15 to 0.93; p = 0.03). The study provides an estimator of risk of LAEs in LQTS that allows a granular estimate of 5-year arrhythmic risk and demonstrate the superiority of nadolol in reducing the risk of LAEs in LQTS. Copyright © 2018 American College of Cardiology Foundation. Published by Elsevier Inc. All rights reserved.

  13. Large-scale Environment of a z = 6.61 Luminous Quasar Probed by Lyα Emitters and Lyman Break Galaxies

    NASA Astrophysics Data System (ADS)

    Ota, Kazuaki; Venemans, Bram P.; Taniguchi, Yoshiaki; Kashikawa, Nobunari; Nakata, Fumiaki; Harikane, Yuichi; Bañados, Eduardo; Overzier, Roderik; Riechers, Dominik A.; Walter, Fabian; Toshikawa, Jun; Shibuya, Takatoshi; Jiang, Linhua

    2018-04-01

    Quasars (QSOs) hosting supermassive black holes are believed to reside in massive halos harboring galaxy overdensities. However, many observations revealed average or low galaxy densities around z ≳ 6 QSOs. This could be partly because they measured galaxy densities in only tens of arcmin2 around QSOs and might have overlooked potential larger-scale galaxy overdensities. Some previous studies also observed only Lyman break galaxies (LBGs; massive older galaxies) and missed low-mass young galaxies, like Lyα emitters (LAEs), around QSOs. Here we present observations of LAE and LBG candidates in ∼700 arcmin2 around a z = 6.61 luminous QSO using the Subaru Telescope Suprime-Cam with narrowband/broadband. We compare their sky distributions, number densities, and angular correlation functions with those of LAEs/LBGs detected in the same manner and comparable data quality in our control blank field. In the QSO field, LAEs and LBGs are clustering in 4–20 comoving Mpc angular scales, but LAEs show mostly underdensity over the field while LBGs are forming 30 × 60 comoving Mpc2 large-scale structure containing 3σ–7σ high-density clumps. The highest-density clump includes a bright (23.78 mag in the narrowband) extended (≳16 kpc) Lyα blob candidate, indicative of a dense environment. The QSO could be part of the structure but is not located exactly at any of the high-density peaks. Near the QSO, LAEs show underdensity while LBGs average to 4σ excess densities compared to the control field. If these environments reflect halo mass, the QSO may not be in the most massive halo but still in a moderately massive one. Based on data collected at Subaru Telescope, which is operated by the National Astronomical Observatory of Japan.

  14. A Magellan M2FS Spectroscopic Survey of Galaxies at 5.5 < z < 6.8: Program Overview and a Sample of the Brightest Lyα Emitters

    NASA Astrophysics Data System (ADS)

    Jiang, Linhua; Shen, Yue; Bian, Fuyan; Zheng, Zhen-Ya; Wu, Jin; Oyarzún, Grecco A.; Blanc, Guillermo A.; Fan, Xiaohui; Ho, Luis C.; Infante, Leopoldo; Wang, Ran; Wu, Xue-Bing; Mateo, Mario; Bailey, John I., III; Crane, Jeffrey D.; Olszewski, Edward W.; Shectman, Stephen; Thompson, Ian; Walker, Matthew G.

    2017-09-01

    We present a spectroscopic survey of high-redshift, luminous galaxies over four square degrees on the sky, aiming to build a large and homogeneous sample of Lyα emitters (LAEs) at z≈ 5.7 and 6.5, and Lyman-break galaxies (LBGs) at 5.5< z< 6.8. The fields that we choose to observe are well studied, such as by the Subaru XMM-Newton Deep Survey and COSMOS. They have deep optical imaging data in a series of broad and narrow bands, allowing for the efficient selection of galaxy candidates. Spectroscopic observations are being carried out using the multi-object spectrograph M2FS on the Magellan Clay telescope. M2FS is efficient enough to identify high-redshift galaxies, owing to its 256 optical fibers deployed over a circular field of view 30\\prime in diameter. We have observed ˜2.5 square degrees. When the program is completed, we expect to identify more than 400 bright LAEs at z≈ 5.7 and 6.5, and a substantial number of LBGs at z≥slant 6. This unique sample will be used to study a variety of galaxy properties and to search for large protoclusters. Furthermore, the statistical properties of these galaxies will be used to probe cosmic reionization. We describe the motivation, program design, target selection, and M2FS observations. We also outline our science goals, and present a sample of the brightest LAEs at z≈ 5.7 and 6.5. This sample contains 32 LAEs with Lyα luminosities higher than 1043 erg s-1. A few of them reach ≥3 × 1043 erg s-1, comparable to the two most luminous LAEs known at z≥slant 6, “CR7” and “COLA1.” These LAEs provide ideal targets to study extreme galaxies in the distant universe.

  15. Evaluation of Antimicrobial Activities of Sequential Spray Applications of Decontamination Treatments on Chicken Carcasses

    PubMed Central

    Benli, Hakan; Sanchez-Plata, Marcos X.; Ilhak, Osman Irfan; Núñez De González, Maryuri T.; Keeton, Jimmy T.

    2015-01-01

    The objective of this study was to evaluate the effects of sequential applications of ɛ-polylysine (EPL) or lauramide arginine ethyl ester (LAE) sprays followed by an acidic calcium sulfate (ACS) spray on inoculated chicken carcasses to reduce Salmonella (Salmonella enterica serovars including Salmonella typhimurium and Salmonella enteritidis) contamination during 6 days of storage (4.4°C). Secondly, reductions of the resident microflora were studied on uninoculated chicken carcasses following the sequential application of the treatments, chilling and 10 days of storage at 4.4°C. The treatment of Salmonella inoculated carcasses with 300 mg/L EPL followed by 30% ACS (EPL300-ACS30) sprays reduced Salmonella counts initially by 1.5 log cfu/mL and then by 1.2 log cfu/mL (p<0.05) following 6 days of storage at 4.4°C. Likewise, 200 mg/L LAE followed by 30% ACS (LAE200-ACS30) treatment reduced initial Salmonella counts on poultry carcasses by 1.8, 1.4 and 1.8 log cfu/mL (p<0.05), respectively, after 0, 3, and 6 days storage. Immediately after the treatments, EPL300-ACS30 and LAE200-ACS30 both reduced Escherichia coli counts significantly by 2.6 and 2.9 log cfu/mL, respectively. EPL300-ACS30 and LAE200-ASC30 were effective in lowering psychrotroph counts by 1 log cfu/mL on day 10 when compared to the control and distilled water treatments. This study demonstrated that EPL300-ACS30 and LAE200-ACS30 were effective in reducing Salmonella on inoculated chicken carcasses both after treatment and during the storage at 4.4°C for up to 6 days. In addition, reductions in psychrotroph counts indicated that these treatments might have the potential to increase the shelf-life of poultry carcasses. PMID:25656180

  16. MORPHOLOGICAL PROPERTIES OF Lyα EMITTERS AT REDSHIFT 4.86 IN THE COSMOS FIELD: CLUMPY STAR FORMATION OR MERGER?

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Kobayashi, Masakazu A. R.; Taniguchi, Yoshiaki; Kajisawa, Masaru

    2016-03-01

    We investigate morphological properties of 61 Lyα emitters (LAEs) at z = 4.86 identified in the COSMOS field, based on Hubble Space Telescope Advanced Camera for Surveys (ACS) imaging data in the F814W band. Out of the 61 LAEs, we find the ACS counterparts for 54 LAEs. Eight LAEs show double-component structures with a mean projected separation of 0.″63 (∼4.0 kpc at z = 4.86). Considering the faintness of these ACS sources, we carefully evaluate their morphological properties, that is, size and ellipticity. While some of them are compact and indistinguishable from the point-spread function (PSF) half-light radius of 0.″07 (∼0.45 kpc),more » the others are clearly larger than the PSF size and spatially extended up to 0.″3 (∼1.9 kpc). We find that the ACS sources show a positive correlation between ellipticity and size and that the ACS sources with large size and round shape are absent. Our Monte Carlo simulation suggests that the correlation can be explained by (1) the deformation effects via PSF broadening and shot noise or (2) the source blending in which two or more sources with small separation are blended in our ACS image and detected as a single elongated source. Therefore, the 46 single-component LAEs could contain the sources that consist of double (or multiple) components with small spatial separation (i.e., ≲0.″3 or 1.9 kpc). Further observation with high angular resolution at longer wavelengths (e.g., rest-frame wavelengths of ≳4000 Å) is inevitable to decipher which interpretation is adequate for our LAE sample.« less

  17. Prebiotic index evaluation of crude laminaran of Sargassum sp. using feces of wistar rats

    NASA Astrophysics Data System (ADS)

    Chamidah, A.

    2018-03-01

    Today, prebiotics are often added to food. This compound is a food substance which could not be digested, yet benefiting the host by selectively stimulating the growth or activity of one or more bacteria in the colon to improve the health of the host. One of the foodstuffs derived from algae, which could not be digested is laminaran (β-Glucan). The relationship between microflora with the added prebiotics was tested by measuring their prebiotic index, which is supported by total sugars and laminaran levels. The results showed that total sugar content of Laminaran Acid Extract (LAE) (9.075 %) was higher than that of Laminaran Modified Extract (LME) (7.355 %), while the laminaran level of LME (42.23 %) was higher than that of LAE (30.92 %). HPLC test result confirmed the presence of laminaran. The obtained prebiotic index values of LAE and LME were 1.29 and 2.10, respectively, with a negative index score for LAE prebiotic, yet positive one for LME in terms of probiotic from Lactobacillus group. Laminaran extract, especially LME, deserves to be regarded as a prebiotic candidate.

  18. Source-gated transistors for order-of-magnitude performance improvements in thin-film digital circuits

    NASA Astrophysics Data System (ADS)

    Sporea, R. A.; Trainor, M. J.; Young, N. D.; Shannon, J. M.; Silva, S. R. P.

    2014-03-01

    Ultra-large-scale integrated (ULSI) circuits have benefited from successive refinements in device architecture for enormous improvements in speed, power efficiency and areal density. In large-area electronics (LAE), however, the basic building-block, the thin-film field-effect transistor (TFT) has largely remained static. Now, a device concept with fundamentally different operation, the source-gated transistor (SGT) opens the possibility of unprecedented functionality in future low-cost LAE. With its simple structure and operational characteristics of low saturation voltage, stability under electrical stress and large intrinsic gain, the SGT is ideally suited for LAE analog applications. Here, we show using measurements on polysilicon devices that these characteristics lead to substantial improvements in gain, noise margin, power-delay product and overall circuit robustness in digital SGT-based designs. These findings have far-reaching consequences, as LAE will form the technological basis for a variety of future developments in the biomedical, civil engineering, remote sensing, artificial skin areas, as well as wearable and ubiquitous computing, or lightweight applications for space exploration.

  19. Source-gated transistors for order-of-magnitude performance improvements in thin-film digital circuits

    PubMed Central

    Sporea, R. A.; Trainor, M. J.; Young, N. D.; Shannon, J. M.; Silva, S. R. P.

    2014-01-01

    Ultra-large-scale integrated (ULSI) circuits have benefited from successive refinements in device architecture for enormous improvements in speed, power efficiency and areal density. In large-area electronics (LAE), however, the basic building-block, the thin-film field-effect transistor (TFT) has largely remained static. Now, a device concept with fundamentally different operation, the source-gated transistor (SGT) opens the possibility of unprecedented functionality in future low-cost LAE. With its simple structure and operational characteristics of low saturation voltage, stability under electrical stress and large intrinsic gain, the SGT is ideally suited for LAE analog applications. Here, we show using measurements on polysilicon devices that these characteristics lead to substantial improvements in gain, noise margin, power-delay product and overall circuit robustness in digital SGT-based designs. These findings have far-reaching consequences, as LAE will form the technological basis for a variety of future developments in the biomedical, civil engineering, remote sensing, artificial skin areas, as well as wearable and ubiquitous computing, or lightweight applications for space exploration. PMID:24599023

  20. The VELVET A Orthologue VEL1 of Trichoderma reesei Regulates Fungal Development and Is Essential for Cellulase Gene Expression

    PubMed Central

    Atanasova, Lea; Fekete, Erzsébet; Paholcsek, Melinda; Sándor, Erzsébet; Aquino, Benigno; Druzhinina, Irina S.; Karaffa, Levente; Kubicek, Christian P.

    2014-01-01

    Trichoderma reesei is the industrial producer of cellulases and hemicellulases for biorefinery processes. Their expression is obligatorily dependent on the function of the protein methyltransferase LAE1. The Aspergillus nidulans orthologue of LAE1 - LaeA - is part of the VELVET protein complex consisting of LaeA, VeA and VelB that regulates secondary metabolism and sexual as well as asexual reproduction. Here we have therefore investigated the function of VEL1, the T. reesei orthologue of A. nidulans VeA. Deletion of the T. reesei vel1 locus causes a complete and light-independent loss of conidiation, and impairs formation of perithecia. Deletion of vel1 also alters hyphal morphology towards hyperbranching and formation of thicker filaments, and with consequently reduced growth rates. Growth on lactose as a sole carbon source, however, is even more strongly reduced and growth on cellulose as a sole carbon source eliminated. Consistent with these findings, deletion of vel1 completely impaired the expression of cellulases, xylanases and the cellulase regulator XYR1 on lactose as a cellulase inducing carbon source, but also in resting mycelia with sophorose as inducer. Our data show that in T. reesei VEL1 controls sexual and asexual development, and this effect is independent of light. VEL1 is also essential for cellulase gene expression, which is consistent with the assumption that their regulation by LAE1 occurs by the VELVET complex. PMID:25386652

  1. A Search for z>6.5 Lyman-alpha Emitting Galaxies with WISP

    NASA Astrophysics Data System (ADS)

    Bagley, Micaela B.; Scarlata, Claudia; Dai, Yu Sophia; Rafelski, Marc; Baronchelli, Ivano; Colbert, James W.; Dominguez, Alberto; Hathi, Nimish P.; Henry, Alaina L.; Malkan, Matthew Arnold; Martin, Crystal L.; Mehta, Vihang; Pahl, Anthony; Ross, Nathaniel; Rutkowski, Michael J.; Teplitz, Harry I.; WISP Team

    2016-01-01

    The observed number density of Lyman-alpha emitting galaxies at z>6 provides an important probe of the reionization history of the universe. Because Lyman-alpha photons are very sensitive to the presence of neutral hydrogen, the evolution of the galaxy number density above redshift 6 can be used as a measurement on the progress of reionization. However, the Lyman-alpha luminosity function is currently poorly constrained at high-z. We present the results of a systematic search for Lyman-alpha emitters (LAEs) at redshifts of ~6.5 to 7.5 using the HST WFC3 Infrared Spectroscopic Parallels (WISP) survey. WISP's uncorrelated fields are well-suited to the study of bright LAEs, minimizing the effects of clustering introduced by a patchy reionization. From the 30 deepest WISP fields, we compile a sample of single-line emitters, confirm redshifts with broadband colors, and identify LAE candidates that have "dropped out" (are undetected at the 1 sigma level) of the WFC3 UVIS filters. By combining our results with other z~7 studies, we determine whether the number density of LAEs evolves past z~6.5.

  2. Spectroscopic observation of Lyα emitters at z ∼ 7.7 and implications on re-ionization

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Faisst, A. L.; Carollo, C. M.; Capak, P.

    2014-06-10

    We present spectroscopic follow-up observations on two bright Lyα emitter (LAE) candidates originally found by Krug et al. at a redshift of z ∼ 7.7 using the Multi-Object Spectrometer for Infra-Red Exploration at Keck. We rule out any line emission at the >5σ level for both objects, putting on solid ground a previous null result for one of the objects. The limits inferred from the non-detections rule out the previous claim of no or even reversed evolution between 5.7 < z < 7.7 in the Lyα luminosity function (LF) and suggest a drop in the Lyα LF consistent with thatmore » seen in Lyman break galaxy (LBG) samples. We model the redshift evolution of the LAE LF using the LBG UV-continuum LF and the observed rest-frame equivalent width distribution. From the comparison of our empirical model with the observed LAE distribution, we estimate lower limits of the neutral hydrogen fraction to be 50%-70% at z ∼ 7.7. Together with this, we find a strong evolution in the Lyα optical depth characterized by (1 + z){sup 2.2} {sup ±} {sup 0.5} beyond z = 6, indicative of a strong evolution of the intergalactic medium. Finally, we extrapolate the LAE LF to z ∼ 9 using our model and show that it is unlikely that large area surveys, like UltraVISTA or Euclid, pick up LAEs at this redshift assuming the current depths and area.« less

  3. Spatial distribution of Ion Precipitation into the High Latitude Inner Magnetosphere using Energetic Neutral Atom (ENA) images over the Declining Phase of Solar Cycle 23

    NASA Astrophysics Data System (ADS)

    Mackler, D. A.; Jahn, J.; Pollock, C. J.

    2013-12-01

    Plamasheet particles transported Earthward during times of active magnetic convection can interact with thermospheric neutrals through charge exchange. The resulting ENAs are free to leave the influence of the magnetosphere and can be remotely detected. ENAs associated with low altitude (300-800 km) ion precipitation in the high latitude inner mangetosphere are termed Low Altitude Emissions (LAEs). LAEs are highly non-isotropic in velocity space such that the pitch angle distribution at the time of charge exchange is near 90 degrees. The observed Geomagnetic Emission Cone (GEC) of LAEs can be mapped spatially, showing where energy is deposited during storm/sub-storm times. In this study we present a statistical look at the particulate albedo of LAEs over the declining phase of solar cycle 23. The particulate albedo is defined as the ratio of the emitting energetic neutrals to the precipitating ions. The precipitating ion differential directional flux maps are built up from combining NOAA 14/15/16 TED and DMSP 13/14/15 SSJ4 data. Low altitude ENA signatures are identified manually using IMAGE/MENA images and selected out. The geomagnetic location of each pixel representing a LAE source region in the neutral images is computed assuming an altitude of 650 km. Before taking the ratio of the resulting flux of neutrals and ions, the Magnetic Local Time (MLT) and Invariant Latitude (IL) bin sizes are changed such that each has less than 20% error in counting statistics. The particulate albedo maps are then evaluated over changes in geomagnetic storm activity.

  4. Bayesian Redshift Classification of Emission-line Galaxies with Photometric Equivalent Widths

    NASA Astrophysics Data System (ADS)

    Leung, Andrew S.; Acquaviva, Viviana; Gawiser, Eric; Ciardullo, Robin; Komatsu, Eiichiro; Malz, A. I.; Zeimann, Gregory R.; Bridge, Joanna S.; Drory, Niv; Feldmeier, John J.; Finkelstein, Steven L.; Gebhardt, Karl; Gronwall, Caryl; Hagen, Alex; Hill, Gary J.; Schneider, Donald P.

    2017-07-01

    We present a Bayesian approach to the redshift classification of emission-line galaxies when only a single emission line is detected spectroscopically. We consider the case of surveys for high-redshift Lyα-emitting galaxies (LAEs), which have traditionally been classified via an inferred rest-frame equivalent width (EW {W}{Lyα }) greater than 20 Å. Our Bayesian method relies on known prior probabilities in measured emission-line luminosity functions and EW distributions for the galaxy populations, and returns the probability that an object in question is an LAE given the characteristics observed. This approach will be directly relevant for the Hobby-Eberly Telescope Dark Energy Experiment (HETDEX), which seeks to classify ˜106 emission-line galaxies into LAEs and low-redshift [{{O}} {{II}}] emitters. For a simulated HETDEX catalog with realistic measurement noise, our Bayesian method recovers 86% of LAEs missed by the traditional {W}{Lyα } > 20 Å cutoff over 2 < z < 3, outperforming the EW cut in both contamination and incompleteness. This is due to the method’s ability to trade off between the two types of binary classification error by adjusting the stringency of the probability requirement for classifying an observed object as an LAE. In our simulations of HETDEX, this method reduces the uncertainty in cosmological distance measurements by 14% with respect to the EW cut, equivalent to recovering 29% more cosmological information. Rather than using binary object labels, this method enables the use of classification probabilities in large-scale structure analyses. It can be applied to narrowband emission-line surveys as well as upcoming large spectroscopic surveys including Euclid and WFIRST.

  5. Reduction of Salmonella on chicken meat and chicken skin by combined or sequential application of lytic bacteriophage with chemical antimicrobials.

    PubMed

    Sukumaran, Anuraj T; Nannapaneni, Rama; Kiess, Aaron; Sharma, Chander Shekhar

    2015-08-17

    The effectiveness of recently approved Salmonella lytic bacteriophage preparation (SalmoFresh™) in reducing Salmonella in vitro and on chicken breast fillets was examined in combination with lauric arginate (LAE) or cetylpyridinium chloride (CPC). In another experiment, a sequential spray application of this bacteriophage (phage) solution on Salmonella inoculated chicken skin after a 20s dip in chemical antimicrobials (LAE, CPC, peracetic acid, or chlorine) was also examined in reducing Salmonella counts on chicken skin. The application of phage in combination with CPC or LAE reduced S. Typhimurium, S. Heidelberg, and S. Enteritidis up to 5 log units in vitro at 4 °C. On chicken breast fillets, phage in combination with CPC or LAE resulted in significant (p<0.05) reductions of Salmonella ranging from 0.5 to 1.3 log CFU/g as compared to control up to 7 days of refrigerated storage. When phage was applied sequentially with chemical antimicrobials, all the treatments resulted in significant reductions of Salmonella. The application of chlorine (30 ppm) and PAA (400 ppm) followed by phage spray (10(9)PFU/ml) resulted in highest Salmonella reductions of 1.6-1.7 and 2.2-2.5l og CFU/cm(2), respectively. In conclusion, the surface applications of phage in combination with LAE or CPC significantly reduced Salmonella counts on chicken breast fillets. However, higher reductions in Salmonella counts were achieved on chicken skin by the sequential application of chemical antimicrobials followed by phage spray. The sequential application of chlorine, PAA, and phage can provide additional hurdles to reduce Salmonella on fresh poultry carcasses or cut up parts. Copyright © 2015 Elsevier B.V. All rights reserved.

  6. Liquid-Arc/Spark-Excitation Atomic-Emission Spectroscopy

    NASA Technical Reports Server (NTRS)

    Schlagen, Kenneth J.

    1992-01-01

    Constituents of solutions identified in situ. Liquid-arc/spark-excitation atomic-emission spectroscopy (LAES) is experimental variant of atomic-emission spectroscopy in which electric arc or spark established in liquid and spectrum of light from arc or spark analyzed to identify chemical elements in liquid. Observations encourage development of LAES equipment for online monitoring of process streams in such industries as metal plating, electronics, and steel, and for online monitoring of streams affecting environment.

  7. The Rest-frame Optical Spectroscopic Properties of Lyalpha-emitters at Z~2.5: The Physical Origins of Strong Lyalpha Emission

    NASA Astrophysics Data System (ADS)

    Trainor, Ryan F.; Strom, Allison L.; Steidel, Charles C.; Rudie, Gwen C.

    2016-12-01

    We present the rest-frame optical spectroscopic properties of 60 faint (R AB ˜ 27; L ˜ 0.1 L *) Lyα-selected galaxies (LAEs) at z ≈ 2.56. These LAEs also have rest-UV spectra of their Lyα emission line morphologies, which trace the effects of interstellar and circumgalactic gas on the escape of Lyα photons. We find that the LAEs have diverse rest-optical spectra, but their average spectroscopic properties are broadly consistent with the extreme low-metallicity end of the populations of continuum-selected galaxies selected at z ≈ 2-3. In particular, the LAEs have extremely high [O III] λ5008/Hβ ratios (log([O III]/Hβ) ˜ 0.8) and low [N II] λ6585/Hα ratios (log([N II]/Hα) < 1.15). Coupled with a detection of the [O III] λ4364 auroral line, these measurements indicate that the star-forming regions in faint LAEs are characterized by high electron temperatures (T e ≈ 1.8 × 104 K), low oxygen abundances (12 + log(O/H) ≈ 8.04, Z neb ≈ 0.22Z ⊙), and high excitations with respect to their more luminous continuum-selected analogs. Several of our faintest LAEs have line ratios consistent with even lower metallicities, including six with 12 + log(O/H) ≈ 6.9-7.4 (Z neb ≈ 0.02-0.05Z ⊙). We interpret these observations in light of new models of stellar evolution (including binary interactions) that have been shown to produce long-lived populations of hot, massive stars at low metallicities. We find that strong, hard ionizing continua are required to reproduce our observed line ratios, suggesting that faint galaxies are efficient producers of ionizing photons and important analogs of reionization-era galaxies. Furthermore, we investigate the physical trends accompanying Lyα emission across the largest current sample of combined Lyα and rest-optical galaxy spectroscopy, including both the 60 KBSS-Lyα LAEs and 368 more luminous galaxies at similar redshifts. We find that the net Lyα emissivity (parameterized by the Lyα equivalent width) is

  8. THE REST-FRAME OPTICAL SPECTROSCOPIC PROPERTIES OF LY α -EMITTERS AT z  ∼ 2.5: THE PHYSICAL ORIGINS OF STRONG LY α EMISSION

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Trainor, Ryan F.; Strom, Allison L.; Steidel, Charles C.

    We present the rest-frame optical spectroscopic properties of 60 faint ( R {sub AB} ∼ 27; L ∼ 0.1 L {sub *}) Ly α -selected galaxies (LAEs) at z  ≈ 2.56. These LAEs also have rest-UV spectra of their Ly α emission line morphologies, which trace the effects of interstellar and circumgalactic gas on the escape of Ly α photons. We find that the LAEs have diverse rest-optical spectra, but their average spectroscopic properties are broadly consistent with the extreme low-metallicity end of the populations of continuum-selected galaxies selected at z  ≈ 2–3. In particular, the LAEs have extremely high [O iii]more » λ 5008/H β ratios (log([O iii]/H β ) ∼ 0.8) and low [N ii] λ 6585/H α ratios (log([N ii]/H α ) < 1.15). Coupled with a detection of the [O iii] λ 4364 auroral line, these measurements indicate that the star-forming regions in faint LAEs are characterized by high electron temperatures (T{sub e} ≈ 1.8 × 10{sup 4} K), low oxygen abundances (12 + log(O/H) ≈ 8.04, Z{sub neb} ≈ 0.22 Z {sub ⊙}), and high excitations with respect to their more luminous continuum-selected analogs. Several of our faintest LAEs have line ratios consistent with even lower metallicities, including six with 12 + log(O/H) ≈ 6.9–7.4 (Z {sub neb} ≈ 0.02–0.05 Z{sub ⊙}). We interpret these observations in light of new models of stellar evolution (including binary interactions) that have been shown to produce long-lived populations of hot, massive stars at low metallicities. We find that strong, hard ionizing continua are required to reproduce our observed line ratios, suggesting that faint galaxies are efficient producers of ionizing photons and important analogs of reionization-era galaxies. Furthermore, we investigate the physical trends accompanying Ly α emission across the largest current sample of combined Ly α and rest-optical galaxy spectroscopy, including both the 60 KBSS-Ly α LAEs and 368 more luminous galaxies at similar

  9. Stellar Populations of Lyα Emitters at z ~ 6-7: Constraints on the Escape Fraction of Ionizing Photons from Galaxy Building Blocks

    NASA Astrophysics Data System (ADS)

    Ono, Yoshiaki; Ouchi, Masami; Shimasaku, Kazuhiro; Dunlop, James; Farrah, Duncan; McLure, Ross; Okamura, Sadanori

    2010-12-01

    We investigate the stellar populations of Lyα emitters (LAEs) at z = 5.7 and 6.6 in a 0.65 deg2 sky of the Subaru/XMM-Newton Deep Survey (SXDS) Field, using deep images taken with the Subaru/Suprime-Cam, United Kingdom Infrared Telescope/Wide Field Infrared Camera, and Spitzer/Infrared Array Camera (IRAC). We produce stacked multiband images at each redshift from 165 (z = 5.7) and 91 (z = 6.6) IRAC-undetected objects to derive typical spectral energy distributions (SEDs) of z ~ 6-7 LAEs for the first time. The stacked LAEs have as blue UV continua as the Hubble Space Telescope (HST)/Wide Field Camera 3 (WFC3) z-dropout galaxies of similar M UV, with a spectral slope β ~ -3, but at the same time they have red UV-to-optical colors with detection in the 3.6 μm band. Using SED fitting we find that the stacked LAEs have low stellar masses of ~(3-10) × 107 M sun, very young ages of ~1-3 Myr, negligible dust extinction, and strong nebular emission from the ionized interstellar medium, although the z = 6.6 object is fitted similarly well with high-mass models without nebular emission; inclusion of nebular emission reproduces the red UV-to-optical colors while keeping the UV colors sufficiently blue. We infer that typical LAEs at z ~ 6-7 are building blocks of galaxies seen at lower redshifts. We find a tentative decrease in the Lyα escape fraction from z = 5.7 to 6.6, which may imply an increase in the intergalactic medium neutral fraction. From the minimum contribution of nebular emission required to fit the observed SEDs, we place an upper limit on the escape fraction of ionizing photons of f ion esc ~ 0.6 at z = 5.7 and ~0.9 at z = 6.6. We also compare the stellar populations of our LAEs with those of stacked HST/WFC3 z-dropout galaxies. Based on data collected at the Subaru Telescope, which is operated by the National Astronomical Observatory of Japan.

  10. The nature of luminous Lyα emitters at z ˜ 2-3: maximal dust-poor starbursts and highly ionising AGN

    NASA Astrophysics Data System (ADS)

    Sobral, David; Matthee, Jorryt; Darvish, Behnam; Smail, Ian; Best, Philip N.; Alegre, Lara; Röttgering, Huub; Mobasher, Bahram; Stroe, Ana Paulino-Afonso Andra; Oteo, Iván

    2018-03-01

    Deep narrow-band surveys have revealed a large population of faint Lyα emitters (LAEs) in the distant Universe, but relatively little is known about the most luminous sources (L_Lyα {≳} 10^{42.7} erg s-1; L_Lyα {≳} L^*_{Lyα }). Here we present the spectroscopic follow-up of 21 luminous LAEs at z ˜ 2 - 3 found with panoramic narrow-band surveys over five independent extragalactic fields (≈4 × 106 Mpc3 surveyed at z ˜ 2.2 and z ˜ 3.1). We use WHT/ISIS, Keck/DEIMOS and VLT/X-SHOOTER to study these sources using high ionisation UV lines. Luminous LAEs at z ˜ 2-3 have blue UV slopes (β =-2.0^{+0.3}_{-0.1}), high Lyα escape fractions (50^{+20}_{-15}%) and span five orders of magnitude in UV luminosity (M_{UV}≈ -19 to -24). Many (70%) show at least one high ionisation rest-frame UV line such as CIV, NV, CIII], HEII or OIII], typically blue-shifted by ≈100 - 200 km s-1 relative to Lyα. Their Lyα profiles reveal a wide variety of shapes, including significant blue-shifted components and widths from 200 to 4000 km s-1. Overall, 60 ± 11 % appear to be AGN dominated, and at L_{Lyα }>10^{43.3} erg s-1 and/or M_{UV}<-21.5 virtually all LAEs are AGN with high ionisation parameters (log U = 0.6 ± 0.5) and with metallicities of ≈0.5 - 1 Z⊙. Those lacking signatures of AGN (40 ± 11 %) have lower ionisation parameters (log U=-3.0^{+1.6}_{-0.9} and log ξion = 25.4 ± 0.2) and are apparently metal-poor sources likely powered by young, dust-poor "maximal" starbursts. Our results show that luminous LAEs at z ˜ 2-3 are a diverse population and that 2 × L^*_{Lyα } and 2 × M_UV^* mark a sharp transition in the nature of LAEs, from star formation dominated to AGN dominated.

  11. The nature of luminous Ly α emitters at z ˜ 2-3: maximal dust-poor starbursts and highly ionizing AGN

    NASA Astrophysics Data System (ADS)

    Sobral, David; Matthee, Jorryt; Darvish, Behnam; Smail, Ian; Best, Philip N.; Alegre, Lara; Röttgering, Huub; Mobasher, Bahram; Paulino-Afonso, Ana; Stroe, Andra; Oteo, Iván

    2018-06-01

    Deep narrow-band surveys have revealed a large population of faint Ly α emitters (LAEs) in the distant Universe, but relatively little is known about the most luminous sources ({L}_{Lyα } ≳ 10^{42.7} erg s-1; L_{Lyα }≳ L^*_{Lyα }). Here we present the spectroscopic follow-up of 21 luminous LAEs at z ˜ 2-3 found with panoramic narrow-band surveys over five independent extragalactic fields (≈4 × 106 Mpc3 surveyed at z ˜ 2.2 and z ˜ 3.1). We use WHT/ISIS, Keck/DEIMOS, and VLT/X-SHOOTER to study these sources using high ionization UV lines. Luminous LAEs at z ˜ 2-3 have blue UV slopes (β =-2.0^{+0.3}_{-0.1}) and high Ly α escape fractions (50^{+20}_{-15} per cent) and span five orders of magnitude in UV luminosity (MUV ≈ -19 to -24). Many (70 per cent) show at least one high ionization rest-frame UV line such as C IV, N V, C III], He II or O III], typically blue-shifted by ≈100-200 km s-1 relative to Ly α. Their Ly α profiles reveal a wide variety of shapes, including significant blue-shifted components and widths from 200 to 4000 km s-1. Overall, 60 ± 11 per cent appear to be active galactic nucleus (AGN) dominated, and at LLyα > 1043.3 erg s-1 and/or MUV < -21.5 virtually all LAEs are AGNs with high ionization parameters (log U = 0.6 ± 0.5) and with metallicities of ≈0.5 - 1 Z⊙. Those lacking signatures of AGNs (40 ± 11 per cent) have lower ionization parameters (log U=-3.0^{+1.6}_{-0.9} and log ξion = 25.4 ± 0.2) and are apparently metal-poor sources likely powered by young, dust-poor `maximal' starbursts. Our results show that luminous LAEs at z ˜ 2-3 are a diverse population and that 2× L^*_{Lyα } and 2× M_UV^* mark a sharp transition in the nature of LAEs, from star formation dominated to AGN dominated.

  12. Photodiode radiation hardness, lyman-alpha emitting galaxies and photon detection in liquid argon neutrino detectors

    NASA Astrophysics Data System (ADS)

    Baptista, Brian

    2013-12-01

    My dissertation is comprised of three projects: 1) studies of Lyman-alpha Emitting galaxies (LAEs), 2) radiation hardness studies of InGaAs photodiodes (PDs), and 3) scintillation photon detection in liquid argon (LAr) neutrino detectors. I began work on the project that has now become WFIRST, developing a science case that would use WFIRST after launch for the observation of LAEs. The radiation hardness of PDs was as an effort to support the WFIRST calibration team. When WFIRST was significantly delayed, I joined an R&D effort that applied my skills to work on photon detection in LAr neutrino detectors. I report results on a broadband selection method developed to detect high equivalent width (EW) LAEs. Using photometry from the CFHT-Legacy Survey Deep 2 and 3 fields, I have spectroscopically confirmed 63 z=2.5-3.5 LAEs using the WIYN/Hydra spectrograph. Using UV continuum-fitting techniques I computed properties such as EWs, internal reddening and star formation rates. 62 of my LAEs show evidence to be normal dust-free LAEs. Second, I present an investigation into the effects of ionizing proton radiation on commercial off-the-shelf InGaAs PDs. I developed a monochromator-based test apparatus that utilized NIST-calibrated reference PDs. I tested the PDs for changes to their dark current, relative responsivity as a function of wavelength, and absolute responsivity. I irradiated the test PDs using 30, 52, and 98 MeV protons at the IU Cyclotron Facility. I found the InGaAs PDs showed increased dark current as the fluence increased with no evidence of broadband response degradation at the fluences expected at an L2 orbit and a 10-year mission lifetime. Finally, I detail my efforts on technology development of both optical detector technologies and waveshifting light guide construction for LAr vacuum UV scintillation light. Cryogenic neutrino detectors use photon detection for both accelerator based science and for SNe neutrino detection and proton decay. I have

  13. Ly α and UV Sizes of Green Pea Galaxies

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Yang, Huan; Wang, Junxian; Malhotra, Sangeeta

    Green Peas are nearby analogs of high-redshift Ly α -emitting galaxies (LAEs). To probe their Ly α escape, we study the spatial profiles of Ly α and UV continuum emission of 24 Green Pea galaxies using the Cosmic Origins Spectrograph (COS) on the Hubble Space Telescope . We extract the spatial profiles of Ly α emission from their 2D COS spectra, and of the UV continuum from both 2D spectra and NUV images. The Ly α emission shows more extended spatial profiles than the UV continuum, in most Green Peas. The deconvolved full width at half maximum of the Lymore » α spatial profile is about 2–4 times that of the UV continuum, in most cases. Because Green Peas are analogs of high z LAEs, our results suggest that most high- z LAEs probably have larger Ly α sizes than UV sizes. We also compare the spatial profiles of Ly α photons at blueshifted and redshifted velocities in eight Green Peas with sufficient data quality, and find that the blue wing of the Ly α line has a larger spatial extent than the red wing in four Green Peas with comparatively weak blue Ly α line wings. We show that Green Peas and MUSE z = 3–6 LAEs have similar Ly α and UV continuum sizes, which probably suggests that starbursts in both low- z and high- z LAEs drive similar gas outflows illuminated by Ly α light. Five Lyman continuum (LyC) leakers in this sample have similar Ly α to UV continuum size ratios (∼1.4–4.3) to the other Green Peas, indicating that their LyC emissions escape through ionized holes in the interstellar medium.« less

  14. The HETDEX pilot survey. V. The physical origin of Lyα emitters probed by near-infrared spectroscopy

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Song, Mimi; Finkelstein, Steven L.; Gebhardt, Karl

    2014-08-10

    We present the results from a Very Large Telescope/SINFONI and Keck/NIRSPEC near-infrared spectroscopic survey of 16 Lyα emitters (LAEs) at z = 2.1-2.5 in the COSMOS and GOODS-N fields discovered from the Hobby Eberly Telescope Dark Energy Experiment Pilot Survey. We detect rest-frame optical nebular lines (Hα and/or [O III] λ5007) for 10 of the LAEs and measure physical properties, including the star formation rate (SFR), gas-phase metallicity, gas mass fraction, and Lyα velocity offset. We find that LAEs may lie below the mass-metallicity relation for continuum-selected star-forming galaxies at the same redshift. The LAEs all show velocity shifts ofmore » Lyα relative to the systemic redshift ranging between +85 and +296 km s{sup –1} with a mean of +180 km s{sup –1}. This value is smaller than measured for continuum-selected star-forming galaxies at similar redshifts. The Lyα velocity offsets show a moderate correlation with the measured SFR (2.5σ), but no significant correlations are seen with the SFR surface density, specific SFR, stellar mass, or dynamical mass (≲1.5σ). Exploring the role of dust, kinematics of the interstellar medium (ISM), and geometry on the escape of Lyα photons, we find no signature of selective quenching of resonantly scattered Lyα photons. However, we also find no evidence that a clumpy ISM is enhancing the Lyα equivalent width. Our results suggest that the low metallicity in LAEs may be responsible for yielding an environment with a low neutral hydrogen column density and less dust, easing the escape of Lyα photons over that in continuum-selected star-forming galaxies.« less

  15. Monoamine oxidase inhibition by monoterpene indole alkaloids and fractions obtained from Psychotria suterella and Psychotria laciniata.

    PubMed

    Dos Santos Passos, Carolina; Soldi, Tatiane Cristina; Torres Abib, Renata; Anders Apel, Miriam; Simões-Pires, Cláudia; Marcourt, Laurence; Gottfried, Carmem; Henriques, Amélia Teresinha

    2013-06-01

    Alkaloid fractions of Psychotria suterella (SAE) and Psychotria laciniata (LAE) as well as two monoterpene indole alkaloids (MIAs) isolated from these fractions were evaluated against monoamine oxidases (MAO-A and -B) obtained from rat brain mitochondria. SAE and LAE were analysed by HPLC-PDA and UHPLC/HR-TOF-MS leading to the identification of the compounds 1, 2, 3 and 4, whose identity was confirmed by NMR analyses. Furthermore, SAE and LAE were submitted to the enzymatic assays, showing a strong activity against MAO-A, characterized by IC(50) values of 1.37 ± 1.05 and 2.02 ± 1.08 μg/mL, respectively. Both extracts were also able to inhibit MAO-B, but in higher concentrations. In a next step, SAE and LAE were fractionated by RP-MPLC affording three and four major fractions, respectively. The RP-MPLC fractions were subsequently tested against MAO-A and -B. The RP-MPLC fractions SAE-F3 and LAE-F4 displayed a strong inhibition against MAO-A with IC(50) values of 0.57 ± 1.12 and 1.05 ± 1.15 μg/mL, respectively. The MIAs 1 and 2 also inhibited MAO-A (IC(50) of 50.04 ± 1.09 and 132.5 ± 1.33 μg/mL, respectively) and -B (IC(50) of 306.6 ± 1.40 and 162.8 ± 1.26 μg/mL, respectively), but in higher concentrations when compared with the fractions. This is the first work describing the effects of MIAs found in neotropical species of Psychotria on MAO activity. The results suggest that species belonging to this genus could consist of an interesting source in the search for new MAO inhibitors.

  16. Correlating DMSP and NOAA Ion Precipitation Observations with Low Altitude ENA Emissions During the Declining Phase of Solar Cycle 23

    NASA Astrophysics Data System (ADS)

    Mackler, D. A.; Jahn, J. M.; Perez, J. D.; Pollock, C. J.

    2014-12-01

    Plasma sheet particles with sufficiently low mirror points will interact with thermospheric neutrals through charge exchange. The resulting ENAs are no longer magnetically bound and can therefore be detected by remote platforms outside the ionosphere/lower atmosphere. These ENAs closely associated with ion precipitation are termed Low Altitude Emissions (LAEs). They are non-isotropic in velocity space and mimic the corresponding ion pitch angle distribution. In this study we present a statistical correlation between remote observations of the LAE emission characteristics and ion precipitation maps determined in situ over the declining phase of solar cycle 23 (2000-2005). We discuss the strength and derived location (MLT, iMLAT) of LAEs as a function of geomagnetic activity levels in relation to the simultaneously measured strength, location, and spectral characteristics of in situ ion precipitation. These comparisons may allow us to use ENA images to assess where and how much energy is deposited during any type of enhanced geomagnetic activity. The precipitating ion differential directional flux maps are built up from combining NOAA-14/15/16 TED and DMSP-13/14/15 SSJ4 data. Low altitude ENA source locations are identified algorithmically using IMAGE/MENA images. ENA flux maps are derived by computing the LAE source locations assuming an ENA emission altitude (h) of 650 km, then projecting each image pixel onto a sphere with radius Re+h to determine the local time and latitude extent of the ENA source. The IGRF magnetic field model is used in combination with the Solar Magnetic coordinates of LAE pixels to compute the pitch angle of the escaping neutrals (previously ion before charge exchanging). Pitch angles larger than 90° will have a mirror point further into the atmosphere than the assumed emission altitude.

  17. Lyα and UV Sizes of Green Pea Galaxies

    NASA Astrophysics Data System (ADS)

    Yang, Huan; Malhotra, Sangeeta; Rhoads, James E.; Leitherer, Claus; Wofford, Aida; Jiang, Tianxing; Wang, Junxian

    2017-03-01

    Green Peas are nearby analogs of high-redshift Lyα-emitting galaxies (LAEs). To probe their Lyα escape, we study the spatial profiles of Lyα and UV continuum emission of 24 Green Pea galaxies using the Cosmic Origins Spectrograph (COS) on the Hubble Space Telescope. We extract the spatial profiles of Lyα emission from their 2D COS spectra, and of the UV continuum from both 2D spectra and NUV images. The Lyα emission shows more extended spatial profiles than the UV continuum, in most Green Peas. The deconvolved full width at half maximum of the Lyα spatial profile is about 2-4 times that of the UV continuum, in most cases. Because Green Peas are analogs of high z LAEs, our results suggest that most high-z LAEs probably have larger Lyα sizes than UV sizes. We also compare the spatial profiles of Lyα photons at blueshifted and redshifted velocities in eight Green Peas with sufficient data quality, and find that the blue wing of the Lyα line has a larger spatial extent than the red wing in four Green Peas with comparatively weak blue Lyα line wings. We show that Green Peas and MUSE z = 3-6 LAEs have similar Lyα and UV continuum sizes, which probably suggests that starbursts in both low-z and high-z LAEs drive similar gas outflows illuminated by Lyα light. Five Lyman continuum (LyC) leakers in this sample have similar Lyα to UV continuum size ratios (˜1.4-4.3) to the other Green Peas, indicating that their LyC emissions escape through ionized holes in the interstellar medium.

  18. Lyman-α emitters in the context of hierarchical galaxy formation: predictions for VLT/MUSE surveys

    NASA Astrophysics Data System (ADS)

    Garel, T.; Guiderdoni, B.; Blaizot, J.

    2016-02-01

    The VLT/Multi Unit Spectrograph Explorer (MUSE) integral-field spectrograph can detect Lyα emitters (LAE) in the redshift range 2.8 ≲ z ≲ 6.7 in a homogeneous way. Ongoing MUSE surveys will notably probe faint Lyα sources that are usually missed by current narrow-band surveys. We provide quantitative predictions for a typical wedding-cake observing strategy with MUSE based on mock catalogues generated with a semi-analytic model of galaxy formation coupled to numerical Lyα radiation transfer models in gas outflows. We expect ≈1500 bright LAEs (FLyα ≳ 10-17 erg s-1 cm-2) in a typical shallow field (SF) survey carried over ≈100 arcmin2 , and ≈2000 sources as faint as 10-18 erg s-1 cm-2 in a medium-deep field (MDF) survey over 10 arcmin2 . In a typical deep field (DF) survey of 1 arcmin2 , we predict that ≈500 extremely faint LAEs (FLyα ≳ 4 × 10-19 erg s-1 cm-2) will be found. Our results suggest that faint Lyα sources contribute significantly to the cosmic Lyα luminosity and SFR budget. While the host haloes of bright LAEs at z ≈ 3 and 6 have descendants with median masses of 2 × 1012 and 5 × 1013 M⊙, respectively, the faintest sources detectable by MUSE at these redshifts are predicted to reside in haloes which evolve into typical sub-L* and L* galaxy haloes at z = 0. We expect typical DF and MDF surveys to uncover the building blocks of Milky Way-like objects, even probing the bulk of the stellar mass content of LAEs located in their progenitor haloes at z ≈ 3.

  19. Lagrangian averaging with geodesic mean

    NASA Astrophysics Data System (ADS)

    Oliver, Marcel

    2017-11-01

    This paper revisits the derivation of the Lagrangian averaged Euler (LAE), or Euler-α equations in the light of an intrinsic definition of the averaged flow map as the geodesic mean on the volume-preserving diffeomorphism group. Under the additional assumption that first-order fluctuations are statistically isotropic and transported by the mean flow as a vector field, averaging of the kinetic energy Lagrangian of an ideal fluid yields the LAE Lagrangian. The derivation presented here assumes a Euclidean spatial domain without boundaries.

  20. Lagrangian averaging with geodesic mean.

    PubMed

    Oliver, Marcel

    2017-11-01

    This paper revisits the derivation of the Lagrangian averaged Euler (LAE), or Euler- α equations in the light of an intrinsic definition of the averaged flow map as the geodesic mean on the volume-preserving diffeomorphism group. Under the additional assumption that first-order fluctuations are statistically isotropic and transported by the mean flow as a vector field, averaging of the kinetic energy Lagrangian of an ideal fluid yields the LAE Lagrangian. The derivation presented here assumes a Euclidean spatial domain without boundaries.

  1. The Spectroscopic Properties of Lyα-Emitters at z ˜2.7: Escaping Gas and Photons from Faint Galaxies

    NASA Astrophysics Data System (ADS)

    Trainor, Ryan F.; Steidel, Charles C.; Strom, Allison L.; Rudie, Gwen C.

    2015-08-01

    We present a spectroscopic survey of 318 faint ({R}˜ 27, L˜ 0.1{L}*), Lyα-emission-selected galaxies (LAEs) in regions centered on the positions of hyperluminous QSOs (HLQSOs) at 2.5\\lt z\\lt 3. A sample of 32 LAEs with rest-frame optical emission line spectra from Keck/Multi-Object Spectrometer For InfraRed Exploration (MOSFIRE) are used to interpret the LAE spectra in the context of their systemic redshifts. The fields are part of the Keck Baryonic Structure Survey, which includes substantial ancillary multi-wavelength imaging from both the ground and space. From a quantitative analysis of the diverse Lyα spectral morphologies, including line widths, asymmetries, and multi-peaked profiles, we find that peak widths and separations are typically smaller than among samples of more luminous continuum-selected galaxies (Lyman-break galaxies and their analogs; LBGs) at similar redshifts. We find tentative evidence for an association between Lyα spectral morphology and external illumination by the nearby HLQSO. Using the MOSFIRE subsample, we find that the peak of the resolved (R ≈ 1300) Lyα line is shifted by +200 km s-1 with respect to systemic across a diverse set of galaxies including both LAEs and LBGs. We also find a small number of objects with significantly blueshifted Lyα emission, a potential indicator of accreting gas. The Lyα-to-Hα line ratios measured for the MOSFIRE subset suggest that the LAEs in this sample have Lyα escape fractions {f}{esc,{Ly}α } ≈ 30%, significantly higher than typical LBG samples. Using redshifts calibrated by our MOSFIRE sample, we construct composite LAE spectra, finding the first evidence for metal-enriched outflows in such intrinsically faint high-redshift galaxies. These outflows have smaller continuum covering fractions ({f}{{c}}≈ 0.3) and velocities ({v}{ave} ≈ 100-200 km s-1, {v}{max} ≈ 500 km s-1) than those associated with typical LBGs, suggesting that the gas covering fraction is a likely driver of

  2. The very high redshift component of the OTELO survey

    NASA Astrophysics Data System (ADS)

    Bongiovanni, A.; Ramón-Pérez, M.; Pérez García, A. M.; Cepa Nogué, J.; Cervino Saavedra, M.; OTELO Team

    2017-03-01

    Lyman-α emitters (LAEs) and Lyman-break galaxies (LBGs) stand out among the most used tools to study the galaxy formation in the early universe. Despite they constitute truly evolutionary probes of galaxy formation, evidence suggests that LAEs & LBGs correspond to different kinds of extragalactic sources regarding star formation modes, spatial distribution, gas and dust content, nuclear activity, etc., apart from the way they are detected. Such differences gain special significance near the reionization redshift. The OSIRIS Tunable Filter Emission-Line -OTELO- project is a very deep, 2D-spectroscopic (R ˜ 700) blind tomography, defined on a spectral window of 21 nm and centered on 915 nm, which aimsto obtains spectra of all emission line sources in the field, sampling unrelated cosmological volumes between z = 0.4 and 6 (see contributions of Cepa et al., Ramón-Pérez et al. and Nadolny et al. in this Meeting). Data from the OTELO's first pointing (Extended Groth Strip, EGS) and ancillary have been already gathered and reduced. Starting from a sample of 150+ candidates to z > 6 galaxies in the survey in a color diagnostic diagram, we have isolated 7 preliminary LAE candidates by hybrid SED fitting and emission line analysis, including considerations about possible interlopers (e.g. cool Galactic stars and z ˜ 1.3 post-starburst galaxies). A promising LAE candidate at z = 6.531 is shown in this contribution.

  3. Comparison of morphological changes in efferent lymph nodes after implantation of resorbable and non-resorbable implants in rabbits

    PubMed Central

    2011-01-01

    Background Magnesium alloys as biodegradable implant materials received much interest in recent years. It is known that products of implant degradation can induce several types of immune response. Hence, the aim of this study was to examine the morphological changes of efferent lymph nodes after implantation of different resorbable magnesium alloys (MgCa0.8, LAE442) in comparison to commercially available resorbable (PLA) and non-resorbable (titanium) implant materials as well as control groups without implant material. Methods The different implant materials were inserted intramedullary into the rabbit tibia. After postoperative observation periods of three and six months, popliteal lymph nodes were examined histologically and immunhistologically and compared to lymph nodes of sham operated animals and animals without surgery. Haematoxylin and eosin staining was performed for cell differentiation. Mouse anti-CD79α and rat anti-CD3 monoclonal primary antibodies were used for B- and T-lymphocyte detection, mouse anti-CD68 primary antibodies for macrophage detection. Evaluation of all sections was performed applying a semi quantitative score. Results The histological evaluation demonstrated low and moderate levels of morphological changes for both magnesium alloys (LAE442 and MgCa0.8). Higher than moderate values were reached for titanium in sinus histiocytosis and histiocytic apoptosis (3 months) and for PLA in histiocytic apoptosis (3 and 6 months). The immune response to all investigated implants had a non-specific character and predominantly was a foreign-body reaction. LAE442 provoked the lowest changes which might be due to a lower degradation rate in comparison to MgCa0.8. Therewith it is a promising candidate for implants with low immunogenic potential. Conclusion Both examined magnesium alloys did not cause significantly increased morphological changes in efferent lymph nodes in comparison to the widely used implant materials titanium and PLA. LAE442

  4. The MUSE Hubble Ultra Deep Field Survey. X. Lyα equivalent widths at 2.9 < z < 6.6

    NASA Astrophysics Data System (ADS)

    Hashimoto, T.; Garel, T.; Guiderdoni, B.; Drake, A. B.; Bacon, R.; Blaizot, J.; Richard, J.; Leclercq, F.; Inami, H.; Verhamme, A.; Bouwens, R.; Brinchmann, J.; Cantalupo, S.; Carollo, M.; Caruana, J.; Herenz, E. C.; Kerutt, J.; Marino, R. A.; Mitchell, P.; Schaye, J.

    2017-11-01

    We present rest-frame Lyα equivalent widths (EW0) of 417 Lyα emitters (LAEs) detected with Multi Unit Spectroscopic Explorer (MUSE) on the Very Large Telescope (VLT) at 2.9 LAEs reach unprecedented depths, both in Lyα luminosities and UV absolute magnitudes, from log (LLyα/erg s-1) 41.0 to 43.0 and from MUV -16 to -21 (0.01-1.0 L*z=3). The EW0 values span the range of 5 to 240 Å or larger, and their distribution can be well fitted by an exponential law N = N0 exp(-EW0/w0). Owing to the high dynamic range in MUV, we find that the scale factor, w0, depends on MUV in the sense that including fainter MUV objects increases w0, i.e., the Ando effect. The results indicate that selection functions affect the EW0 scale factor. Taking these effects into account, we find that our w0 values are consistent with those in the literature within 1σ uncertainties at 2.9 < z < 6.6 at a given threshold of MUV and LLyα. Interestingly, we find 12 objects with EW0> 200 Å above 1σ uncertainties. Two of these 12 LAEs show signatures of merger or AGN activity: the weak Civλ1549 emission line. For the remaining 10 very large EW0 LAEs, we find that the EW0 values can be reproduced by young stellar ages (< 100 Myr) and low metallicities (≲ 0.02 Z⊙). Otherwise, at least part of the Lyα emission in these LAEs needs to arise from anisotropic radiative transfer effects, fluorescence by hidden AGN or quasi-stellar object activity, or gravitational cooling.

  5. Empowering line intensity mapping to study early galaxies

    NASA Astrophysics Data System (ADS)

    Comaschi, P.; Ferrara, A.

    2016-12-01

    Line intensity mapping is a superb tool to study the collective radiation from early galaxies. However, the method is hampered by the presence of strong foregrounds, mostly produced by low-redshift interloping lines. We present here a general method to overcome this problem which is robust against foreground residual noise and based on the cross-correlation function ψαL(r) between diffuse line emission and Lyα emitters (LAE). We compute the diffuse line (Lyα is used as an example) emission from galaxies in a (800 Mpc)3 box at z = 5.7 and 6.6. We divide the box in slices and populate them with 14 000(5500) LAEs at z = 5.7(6.6), considering duty cycles from 10-3 to 1. Both the LAE number density and slice volume are consistent with the expected outcome of the Subaru Hyper Suprime Cam survey. We add Gaussian random noise with variance σN up to 100 times the variance of the Lyα emission, σα, to simulate residual foregrounds and compute ψαL(r). We find that the signal-to-noise ratio of the observed ψαL(r) does not change significantly if σN ≤ 10σα and show that in these conditions the mean line intensity, ILyα, can be precisely recovered independently of the LAE duty cycle. Even if σN = 100σα, Iα can be constrained within a factor 2. The method works equally well for any other line (e.g. [C II], He II) used for the intensity-mapping experiment.

  6. The MUSE Hubble Ultra Deep Field Survey. VI. The faint-end of the Lyα luminosity function at 2.91 < z < 6.64 and implications for reionisation

    NASA Astrophysics Data System (ADS)

    Drake, A. B.; Garel, T.; Wisotzki, L.; Leclercq, F.; Hashimoto, T.; Richard, J.; Bacon, R.; Blaizot, J.; Caruana, J.; Conseil, S.; Contini, T.; Guiderdoni, B.; Herenz, E. C.; Inami, H.; Lewis, J.; Mahler, G.; Marino, R. A.; Pello, R.; Schaye, J.; Verhamme, A.; Ventou, E.; Weilbacher, P. M.

    2017-11-01

    We present the deepest study to date of the Lyα luminosity function in a blank field using blind integral field spectroscopy from MUSE. We constructed a sample of 604 Lyα emitters (LAEs) across the redshift range 2.91 < z < 6.64 using automatic detection software in the Hubble Ultra Deep Field. The deep data cubes allowed us to calculate accurate total Lyα fluxes capturing low surface-brightness extended Lyα emission now known to be a generic property of high-redshift star-forming galaxies. We simulated realistic extended LAEs to fully characterise the selection function of our samples, and performed flux-recovery experiments to test and correct for bias in our determination of total Lyα fluxes. We find that an accurate completeness correction accounting for extended emission reveals a very steep faint-end slope of the luminosity function, α, down to luminosities of log10L erg s-1< 41.5, applying both the 1 /Vmax and maximum likelihood estimators. Splitting the sample into three broad redshift bins, we see the faint-end slope increasing from -2.03-0.07+ 1.42 at z ≈ 3.44 to -2.86-∞+0.76 at z ≈ 5.48, however no strong evolution is seen between the 68% confidence regions in L∗-α parameter space. Using the Lyα line flux as a proxy for star formation activity, and integrating the observed luminosity functions, we find that LAEs' contribution to the cosmic star formation rate density rises with redshift until it is comparable to that from continuum-selected samples by z ≈ 6. This implies that LAEs may contribute more to the star-formation activity of the early Universe than previously thought, as any additional intergalactic medium (IGM) correction would act to further boost the Lyα luminosities. Finally, assuming fiducial values for the escape of Lyα and LyC radiation, and the clumpiness of the IGM, we integrated the maximum likelihood luminosity function at 5.00

  7. Use of an Electrostatic Spraying System or the Sprayed Lethality in Container Method To Deliver Antimicrobial Agents onto the Surface of Beef Subprimals To Control Shiga Toxin-Producing Escherichia coli.

    PubMed

    Stella, J Max; Luchansky, John B; Miller, Kelsey; Shoyer, Bradley A; Shane, Laura E; McGeary, Lianna; Osoria, Manuela; Stahler, Laura J; Sevart, Nicholas J; Phebus, Randall K; Thippareddi, Harshavardhan; Porto-Fett, Anna C S

    2017-08-01

    The efficacy of an electrostatic spraying system (ESS) and/or the sprayed lethality in container (SLIC) method to deliver antimicrobial agents onto the surface of beef subprimals to reduce levels of Shiga toxin-producing Escherichia coli (STEC) was evaluated. Beef subprimals were surface inoculated (lean side; ca. 5.8 log CFU per subprimal) with 2 mL of an eight-strain cocktail comprising single strains of rifampin-resistant (100 μg/mL) STEC (O26:H11, O45:H2, O103:H2, O104:H4, O111:H - , O121:H19, O145:NM, and O157:H7). Next, inoculated subprimals were surface treated with lauric arginate (LAE; 1%), peroxyacetic acid (PAA; 0.025%), or cetylpyridinium chloride (CPC; 0.4%) by passing each subprimal, with the inoculated lean side facing upward, through an ESS cabinet or via SLIC. Subprimals were then vacuum packaged and stored at 4°C. One set of subprimals was sampled after an additional 2 h, 3 days, or 7 days of refrigerated storage, whereas another set was retreated via SLIC after 3 days of storage with a different one of the three antimicrobial agents (e.g., a subprimal treated with LAE on day 0 was then treated with PAA or CPE on day 3). Retreated subprimals were sampled after 2 h or 4 days of additional storage at 4°C. A single initial application of LAE, PAA, or CPC via ESS or SLIC resulted in STEC reductions of ca. 0.3 to 1.3 log CFU per subprimal after 7 days of storage. However, when subprimals were initially treated with LAE, PAA, or CPC via ESS or SLIC and then separately retreated with a different one of these antimicrobial agents via SLIC on day 3, additional STEC reductions of 0.4 to 1.0 log CFU per subprimal were observed after an additional 4 days of storage. Application of LAE, PAA, or CPC, either alone or in combination, via ESS or SLIC is effective for reducing low levels (ca. 0.3 to 1.6 log CFU) of STEC that may be naturally present on the surface of beef subprimals.

  8. Diagnosis of Nonischemic Stage B Heart Failure in Type 2 Diabetes Mellitus: Optimal Parameters for Prediction of Heart Failure.

    PubMed

    Wang, Ying; Yang, Hong; Huynh, Quan; Nolan, Mark; Negishi, Kazuaki; Marwick, Thomas H

    2018-05-11

    This study sought to identify whether impaired global longitudinal strain (GLS), diastolic dysfunction (DD), or left atrial enlargement (LAE) should be added to stage B heart failure (SBHF) criteria in asymptomatic patients with type 2 diabetes mellitus. SBHF is a precursor to clinical heart failure (HF), and its recognition justifies initiation of cardioprotective therapy. However, original definitions of SBHF were based on LV hypertrophy and impaired ejection fraction. Patients with asymptomatic type 2 diabetes mellitus ≥65 years-of-age (age 71 ± 4 years; 55% men) with preserved ejection fraction and no ischemic heart disease were recruited from a community-based population. All underwent a standard clinical evaluation, and a comprehensive echocardiogram, including assessment of left ventricular hypertrophy (LVH), LAE, DD (abnormal E/e'), and GLS (<16%). Over a median follow-up of 1.5 years (range 0.5 to 3), 20 patients were lost to follow-up, and 290 individuals were entered into the final analyses. In this asymptomatic group, LV dysfunction was identified in 30 (10%) by DD, 68 (23%) by LVH, 102 (35%) by LAE, and 68 (23%) by impaired GLS. New-onset HF developed in 45 patients and 4 died, giving an event rate of 112/1,000 person-years. Survival free of the composite endpoint (HF and death) was about 1.5-fold higher in patients without a normal, compared with an abnormal echocardiogram. LVH, LAE, and GLS <16% were associated with increased risk of the composite endpoint, independent of ARIC risk score and glycosylated hemoglobin, but abnormal E/e' was not. The addition of left atrial volume and GLS provided incremental value to the current standard of clinical risk (ARIC score) and LVH. In a competing-risks regression analysis, LVH (hazard ratio: 2.90; p < 0.001) and GLS <16% (hazard ratio: 2.26; p = 0.008), but not DD and LAE were associated with incident HF. Subclinical left ventricular systolic dysfunction is prevalent in asymptomatic elderly patients

  9. Investigating the control of Listeria monocytogenes on a ready-to-eat ham product using natural antimicrobial ingredients and postlethality interventions.

    PubMed

    Lavieri, Nicolas A; Sebranek, Joseph G; Brehm-Stecher, Byron F; Cordray, Joseph C; Dickson, James S; Horsch, Ashley M; Jung, Stephanie; Larson, Elaine M; Manu, David K; Mendonça, Aubrey F

    2014-06-01

    Ready-to-eat (RTE) meat and poultry products manufactured with natural or organic methods are at greater risk for Listeria monocytogenes growth, if contaminated, than their conventional counterparts due to the required absence of preservatives and antimicrobials. Thus, the objective of this study was to investigate the use of commercially available natural antimicrobials and postlethality interventions in the control of L. monocytogenes growth and recovery on a RTE ham product. Antimicrobials evaluated were cranberry powder (90MX), vinegar (DV), and vinegar/lemon juice concentrate (LV1X). Postlethality interventions studied were high hydrostatic pressure at 400 (HHP400) or 600 (HHP600) MPa, lauric arginate (LAE), octanoic acid (OA), and postpackaging thermal treatment (PPTT). Parameters evaluated through 98 days of storage at 4±1°C were residual nitrite concentrations, pH, a(w), and viable L. monocytogenes on modified Oxford (MOX) media. On day 1, OA, 90MX, DV, and LV1X yielded lower residual nitrite concentrations than the control, whereas HHP400, HHP600, and LAE did not. LAE, HHP400, and OA reduced L. monocytogenes population compared to the control after 1 day of storage by 2.38, 2.21, and 1.73 log10 colony-forming units per gram, respectively. PPTT did not achieve a significant reduction in L. monocytogenes populations. L. monocytogenes recovered and grew in all postlethality intervention treatments except HHP600. 90MX did not inhibit the growth of L. monocytogenes, while DV and LV1X did. Results of this study demonstrate the bactericidal properties of HHP, OA, and LAE and the bacteriostatic potential of natural antimicrobial ingredients such as DV and LV1X against L. monocytogenes.

  10. Revitalization of a Forward Genetic Screen Identifies Three New Regulators of Fungal Secondary Metabolism in the Genus Aspergillus

    PubMed Central

    Pfannenstiel, Brandon T.; Zhao, Xixi; Wortman, Jennifer; Throckmorton, Kurt; Spraker, Joseph E.; Luo, Xingyu; Lindner, Daniel L.; Lim, Fang Yun; Knox, Benjamin P.; Haas, Brian; Fischer, Gregory J.; Choera, Tsokyi; Butchko, Robert A. E.; Bok, Jin-Woo; Affeldt, Katharyn J.

    2017-01-01

    ABSTRACT The study of aflatoxin in Aspergillus spp. has garnered the attention of many researchers due to aflatoxin’s carcinogenic properties and frequency as a food and feed contaminant. Significant progress has been made by utilizing the model organism Aspergillus nidulans to characterize the regulation of sterigmatocystin (ST), the penultimate precursor of aflatoxin. A previous forward genetic screen identified 23 A. nidulans mutants involved in regulating ST production. Six mutants were characterized from this screen using classical mapping (five mutations in mcsA) and complementation with a cosmid library (one mutation in laeA). The remaining mutants were backcrossed and sequenced using Illumina and Ion Torrent sequencing platforms. All but one mutant contained one or more sequence variants in predicted open reading frames. Deletion of these genes resulted in identification of mutant alleles responsible for the loss of ST production in 12 of the 17 remaining mutants. Eight of these mutations were in genes already known to affect ST synthesis (laeA, mcsA, fluG, and stcA), while the remaining four mutations (in laeB, sntB, and hamI) were in previously uncharacterized genes not known to be involved in ST production. Deletion of laeB, sntB, and hamI in A. flavus results in loss of aflatoxin production, confirming that these regulators are conserved in the aflatoxigenic aspergilli. This report highlights the multifaceted regulatory mechanisms governing secondary metabolism in Aspergillus. Additionally, these data contribute to the increasing number of studies showing that forward genetic screens of fungi coupled with whole-genome resequencing is a robust and cost-effective technique. PMID:28874473

  11. The application of liquid air energy storage for large scale long duration solutions to grid balancing

    NASA Astrophysics Data System (ADS)

    Brett, Gareth; Barnett, Matthew

    2014-12-01

    Liquid Air Energy Storage (LAES) provides large scale, long duration energy storage at the point of demand in the 5 MW/20 MWh to 100 MW/1,000 MWh range. LAES combines mature components from the industrial gas and electricity industries assembled in a novel process and is one of the few storage technologies that can be delivered at large scale, with no geographical constraints. The system uses no exotic materials or scarce resources and all major components have a proven lifetime of 25+ years. The system can also integrate low grade waste heat to increase power output. Founded in 2005, Highview Power Storage, is a UK based developer of LAES. The company has taken the concept from academic analysis, through laboratory testing, and in 2011 commissioned the world's first fully integrated system at pilot plant scale (300 kW/2.5 MWh) hosted at SSE's (Scottish & Southern Energy) 80 MW Biomass Plant in Greater London which was partly funded by a Department of Energy and Climate Change (DECC) grant. Highview is now working with commercial customers to deploy multi MW commercial reference plants in the UK and abroad.

  12. Direct evidence for Lyboldsymbol{alpha } depletion in the protocluster core

    NASA Astrophysics Data System (ADS)

    Shimakawa, Rhythm; Kodama, Tadayuki; Hayashi, Masao; Tanaka, Ichi; Matsuda, Yuichi; Kashikawa, Nobunari; Shibuya, Takatoshi; Tadaki, Ken-ichi; Koyama, Yusei; Suzuki, Tomoko L.; Yamamoto, Moegi

    2017-06-01

    We have carried out panoramic Lyα narrow-band imaging with Suprime-Cam on Subaru towards the known protocluster USS1558-003 at z = 2.53. Our previous narrow-band imaging in the near-infrared identified multiple dense groups of Hα emitters (HAEs) within the protocluster. We have now identified the large-scale structures across a ˜50 comoving Mpc scale traced by Lyα emitters (LAEs) in which the protocluster traced by the HAEs is embedded. On a smaller scale, however, there are remarkably few LAEs in the regions of HAE overdensities. Moreover, the stacking analyses of the images show that HAEs in higher-density regions show systematically lower escape fractions of Lyα photons than those of HAEs in lower-density regions. These phenomena may be driven by the extra depletion of Lyα emission lines along our line of sight by more intervening cold circumgalactic/intergalactic medium and/or dust in the dense core. We also caution that all the previous high-z protocluster surveys using LAEs as tracers would have largely missed galaxies in the very dense cores of the protoclusters where we would expect to see any early environmental effects.

  13. Comparison of lead attenuation and lead hardening equivalence of materials used in respect of diagnostic X-ray shielding.

    PubMed

    Okunade, Akintunde Akangbe

    2002-12-01

    Present interest is in the shielding of diagnostic X-ray units. Numerical comparison has been made of the attenuation and hardening properties of lead and some particular alternative materials: steel, plate glass and gypsum wallboard. Results show, for particular choices of thickness, that lead and steel can be made to provide closely similar attenuation and spectral hardening, values of lead attenuation equivalent (LAE) and lead hardening equivalent (LHE) thicknesses being nearly the same. Significant differences in the attenuation and hardening properties of lead are found in comparison with plate glass and gypsum wallboard. LAE produces better matching of exposure for lead-plate glass and lead-gypsum wallboard than LHE.

  14. Two new advanced forms of spectrometry for space and commercial applications

    NASA Technical Reports Server (NTRS)

    Schlager, Kenneth J.

    1991-01-01

    Reagentless ultraviolet absorption spectrometry (UVAS) and Liquid Atomic Emission Spectrometry (LAES) represent new forms of spectrometry with extensive potential in both space and commercial applications. Originally developed under KSC sponsorship for monitoring nutrient solutions for the Controlled Ecological Life Support System (CELSS), both UVAS and LAES have extensive analytical capabilities for both organic and inorganic chemical compounds. Both forms of instrumentation involve the use of remote fiber optic probes and real-time measurements for on-line process monitoring. Commercial applications exist primarily in environmental analysis and for process control in the chemical, pulp and paper, food processing, metal plating, and water/wastewater treatment industries.

  15. Probing the Metal Enrichment of the Intergalactic Medium at z = 5-6 Using the Hubble Space Telescope

    NASA Astrophysics Data System (ADS)

    Cai, Zheng; Fan, Xiaohui; Dave, Romeel; Finlator, Kristian; Oppenheimer, Ben

    2017-11-01

    We test the galactic outflow model by probing associated galaxies of four strong intergalactic C IV absorbers at z = 5-6 using the Hubble Space Telescope (HST) Advanced Camera for Surveys (ACS) ramp narrowband filters. The four strong C IV absorbers reside at z = 5.74, 5.52, 4.95, and 4.87, with column densities ranging from N C IV = 1013.8 to 1014.8 cm-2. At z = 5.74, we detect an I-dropout Lyα emitter (LAE) candidate with a projected impact parameter of 42 physical kpc from the C IV absorber. This LAE candidate has a Lyα-based star formation rate (SFRLyα ) of 2 M ⊙ yr-1 and a UV-based SFR of 4 M ⊙ yr-1. Although we cannot completely rule out that this I-dropout emitter may be an [O II] interloper, its measured properties are consistent with the C IV powered galaxy at z = 5.74. For C IV absorbers at z = 4.95 and z = 4.87, although we detect two LAE candidates with impact parameters of 160 and 200 kpc, such distances are larger than that predicted from the simulations. Therefore, we treat them as nondetections. For the system at z = 5.52, we do not detect LAE candidates, placing a 3σ upper limit of SFRLyα ≈ 1.5 M ⊙ yr-1. In summary, in these four cases, we only detect one plausible C IV source at z = 5.74. Combining the modest SFR of the one detection and the three nondetections, our HST observations strongly support that smaller galaxies (SFRLyα ≲ 2 M ⊙ yr-1) are main sources of intergalactic C IV absorbers, and such small galaxies play a major role in the metal enrichment of the intergalactic medium at z ≳ 5.

  16. DEEP LBT/LUCI SPECTROSCOPY OF AN Ly{alpha} EMITTER CANDIDATE AT z {approx_equal} 7.7

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Jiang Linhua; Bian Fuyan; Fan Xiaohui

    2013-07-01

    We present deep spectroscopic observations of an Ly{alpha} emitter (LAE) candidate at z {approx_equal} 7.7 using the infrared spectrograph LUCI on the 2 Multiplication-Sign 8.4 m Large Binocular Telescope (LBT). The candidate is the brightest among the four z {approx_equal} 7.7 LAE candidates found in a narrowband imaging survey by Krug et al. Our spectroscopic data include a total of 7.5 hr of integration with LBT/LUCI and are deep enough to significantly (3.2{sigma}-4.9{sigma}) detect the Ly{alpha} emission line of this candidate based on its Ly{alpha} flux 1.2 Multiplication-Sign 10{sup -17} erg s{sup -1} cm{sup -2} estimated from the narrowband photometry.more » However, we do not find any convincing signal at the expected position of its Ly{alpha} emission line, suggesting that this source is not an LAE at z {approx_equal} 7.7. The non-detection in this work, together with the previous studies of z {approx_equal} 7.7 LAEs, puts a strong constraint on the bright-end Ly{alpha} luminosity function (LF) at z {approx_equal} 7.7. We find a rapid evolution of the Ly{alpha} LF from z {approx_equal} 6.5 to 7.7: the upper limit of the z {approx_equal} 7.7 LF is more than five times lower than the z {approx_equal} 6.5 LF at the bright end (f{>=} 1.0 Multiplication-Sign 10{sup -17} erg s{sup -1} cm{sup -2} or L{>=} 6.9 Multiplication-Sign 10{sup 42} erg s{sup -1}). This is likely caused by an increasing neutral fraction in the intergalactic medium that substantially attenuates Ly{alpha} emission at z {approx_equal} 7.7.« less

  17. Influence of droplet charge on the chemical stability of citral in oil-in-water emulsions.

    PubMed

    Choi, Seung Jun; Decker, Eric Andrew; Henson, Lulu; Popplewell, L Michael; McClements, David Julian

    2010-08-01

    The chemical stability of citral, a flavor component widely used in beverage, food, and fragrance products, in oil-in-water emulsions stabilized by surfactants with different charge characteristics was investigated. Emulsions were prepared using cationic (lauryl alginate, LAE), non-ionic (polyoxyethylene (23) lauryl ether, Brij 35), and anionic (sodium dodecyl sulfate, SDS) surfactants at pH 3.5. The citral concentration decreased over time in all the emulsions, but the rate of decrease depended on surfactant type. After 7 d storage, the citral concentrations remaining in the emulsions were around 60% for LAE- or Brij 35-stabilized emulsions and 10% for SDS-stabilized emulsions. An increase in the local proton (H(+)) concentration around negatively charged droplet surfaces may account for the more rapid citral degradation observed in SDS-stabilized emulsions. A strong metal ion chelator (EDTA), which has previously been shown to be effective at increasing the oxidative stability of labile components, had no effect on citral stability in LAE- or Brij 35-stabilized emulsions, but it slightly decreased the initial rate of citral degradation in SDS-stabilized emulsions. These results suggest the surfactant type used to prepare emulsions should be controlled to improve the chemical stability of citral in emulsion systems.

  18. New SIMS U-Pb age constraints on the largest lake transgression event in the Songliao Basin, NE China.

    PubMed

    Xi, Dangpeng; He, Huaiyu; Yu, Zhiqiang; Huang, Qinghua; Hu, Jianfang; Xu, Yankang; Shi, Zhongye; Qin, Zuohuan; Wan, Xiaoqiao

    2018-01-01

    The largest lake transgression event (LTE) associated with lake anoxic events (LAE) and periodic seawater incursion events (SWIE) in the Songliao Basin, northeastern China, occurred during deposition of the Cretaceous Nenjiang Formation. The Yaojia-Nenjiang Formation boundary (YNB) marks the beginning of the LTE, as well as LAE and SWIE. However, there is an absence of direct radioisotopic dating, and therefore the age of the YNB, as well as the beginning of LTE, together with their relationship with other geological events, is strongly debated. Here we present a new SIMS U-Pb zircon age from the lowermost Nenjiang Formation. The bentonite bed located 9.88 m above the YNB of the X1-4 borehole was analyzed. Twenty-five analyses of 25 zircons were conducted, which produced a weighted mean age of 85.5±0.6 Ma (MSWD = 0.87). Based on the average sediment accumulation rate, the age of the YNB is suggested to be 85.7 Ma, indicating that the LTE began in the Early Santonian. The new ages provide a precise chronostratigraphic framework for climatic and geological events. Our new results imply that the beginning of the LTE, LAE and SWIE occurred almost simultaneously with short-term sea level rise, and probably had a close relationship with OAE3.

  19. Accelerated Evolution of the Lyα Luminosity Function at z >~ 7 Revealed by the Subaru Ultra-deep Survey for Lyα Emitters at z = 7.3

    NASA Astrophysics Data System (ADS)

    Konno, Akira; Ouchi, Masami; Ono, Yoshiaki; Shimasaku, Kazuhiro; Shibuya, Takatoshi; Furusawa, Hisanori; Nakajima, Kimihiko; Naito, Yoshiaki; Momose, Rieko; Yuma, Suraphong; Iye, Masanori

    2014-12-01

    We present the ultra-deep Subaru narrowband imaging survey for Lyα emitters (LAEs) at z = 7.3 in the Subaru/XMM-Newton Deep Survey (SXDS) and Cosmic Evolution Survey (COSMOS) fields (~0.5 deg2) with a total integration time of 106 hr. Exploiting our new sharp bandwidth filter, NB101, installed on the Suprime-Cam, we have reached L(Lyα) = 2.4 × 1042 erg s-1 (5σ) for z = 7.3 LAEs, about four times deeper than previous Subaru z >~ 7 studies, which allows us to reliably investigate the evolution of the Lyα luminosity function (LF) for the first time down to the luminosity limit same as those of Subaru z = 3.1-6.6 LAE samples. Surprisingly, we only find three and four LAEs in the SXDS and COSMOS fields, respectively, while one expects a total of ~65 LAEs by our survey in the case of no Lyα LF evolution from z = 6.6 to 7.3. We identify a decrease of the Lyα LF from z = 6.6 to 7.3 at the >90% confidence level from our z = 7.3 Lyα LF with the best-fit Schechter parameters of L*{Lyα } = 2.7+8.0-1.2 × 1042 {erg} {s}-1 and φ * = 3.7+17.6-3.3 × 10-4 {Mpc}-3 for a fixed α = -1.5. Moreover, the evolution of the Lyα LF is clearly accelerated at z > 6.6 beyond the measurement uncertainties including cosmic variance. Because no such accelerated evolution of the UV-continuum LF or the cosmic star formation rate (SFR) is found at z ~ 7, but suggested only at z > 8, this accelerated Lyα LF evolution is explained by physical mechanisms different from a pure SFR decrease but related to the Lyα production and escape in the process of cosmic reionization. Because a simple accelerating increase of intergalactic medium neutral hydrogen absorbing Lyα cannot be reconciled with Thomson scattering of optical depth measurements from WMAP and Planck, our findings may support new physical pictures suggested by recent theoretical studies, such as the existence of HI clumpy clouds within cosmic ionized bubbles that are selectively absorbing Lyα and the large ionizing photon escape

  20. Distinct Roles of Velvet Complex in the Development, Stress Tolerance, and Secondary Metabolism in Pestalotiopsis microspora, a Taxol Producer

    PubMed Central

    Akhberdi, Oren; Zhang, Qian; Wang, Dan; Wang, Haichuan; Hao, Xiaoran; Liu, Yanjie; Wei, Dongsheng; Zhu, Xudong

    2018-01-01

    The velvet family proteins have been shown to play critical roles in fungal secondary metabolism and development. However, variations of the roles have been observed in different fungi. We report here the observation on the role of three velvet complex components VeA, VelB, and LaeA in Pestalotiopsis microspora, a formerly reported taxol-producing fungus. Deletion of individual members led to the retardation of vegetative growth and sporulation and pigmentation, suggesting critical roles in these processes. The mutant strain △velB appeared hypersensitive to osmotic stress and the dye Congo red, whereas △veA and △laeA were little affected by the pressures, suggesting only velB was required for the integrity of the cell wall. Importantly, we found that the genes played distinct roles in the biosynthesis of secondary metabolites in P. microspora. For instance, the production of pestalotiollide B, a previously characterized polyketide, required velB and laeA. In contrast, the veA gene appeared to inhibit the pestalotiollide B (PB) role in its biosynthesis. This study suggests that the three components of the velvet complex are important global regulators, but with distinct roles in hyphal growth, asexual production, and secondary metabolism in P. microspora. This work provides information for further understanding the biosynthesis of secondary metabolism in the fungus. PMID:29538316

  1. Distinct Roles of Velvet Complex in the Development, Stress Tolerance, and Secondary Metabolism in Pestalotiopsis microspora, a Taxol Producer.

    PubMed

    Akhberdi, Oren; Zhang, Qian; Wang, Dan; Wang, Haichuan; Hao, Xiaoran; Liu, Yanjie; Wei, Dongsheng; Zhu, Xudong

    2018-03-14

    The velvet family proteins have been shown to play critical roles in fungal secondary metabolism and development. However, variations of the roles have been observed in different fungi. We report here the observation on the role of three velvet complex components VeA, VelB, and LaeA in Pestalotiopsis microspora , a formerly reported taxol-producing fungus. Deletion of individual members led to the retardation of vegetative growth and sporulation and pigmentation, suggesting critical roles in these processes. The mutant strain △velB appeared hypersensitive to osmotic stress and the dye Congo red, whereas △veA and △laeA were little affected by the pressures, suggesting only velB was required for the integrity of the cell wall. Importantly, we found that the genes played distinct roles in the biosynthesis of secondary metabolites in P. microspora . For instance, the production of pestalotiollide B, a previously characterized polyketide, required velB and laeA . In contrast, the veA gene appeared to inhibit the pestalotiollide B (PB) role in its biosynthesis. This study suggests that the three components of the velvet complex are important global regulators, but with distinct roles in hyphal growth, asexual production, and secondary metabolism in P. microspora . This work provides information for further understanding the biosynthesis of secondary metabolism in the fungus.

  2. In Vivo Degradation Behavior of the Magnesium Alloy LANd442 in Rabbit Tibiae

    PubMed Central

    Ullmann, Berit; Reifenrath, Janin; Dziuba, Dina; Seitz, Jan-Marten; Bormann, Dirk; Meyer-Lindenberg, Andrea

    2011-01-01

    In former studies the magnesium alloy LAE442 showed promising in vivo degradation behavior and biocompatibility. However, reproducibility might be enhanced by replacement of the rare earth composition metal “E” by only a single rare earth element. Therefore, it was the aim of this study to examine whether the substitution of “E” by neodymium (“Nd”) had an influence on the in vivo degradation rate. LANd442 implants were inserted into rabbit tibiae and rabbits were euthanized after 4, 8, 13 and 26 weeks postoperatively. In vivo µCT was performed to evaluate the in vivo implant degradation behaviour by calculation of implant volume, density true 3-D thickness and corrosion rates. Additionally, weight loss, type of corrosion and mechanical stability were appraised by SEM/EDS-analysis and three-point bending tests. Implant volume, density and true 3-D thickness decreased over time, whereas the variance of the maximum diameters within an implant as well as the corrosion rate and weight loss increased. SEM examination revealed mainly pitting corrosion after 26 weeks. The maximum bending forces decreased over time. In comparison to LAE442, the new alloy showed a slower, but more uneven degradation behavior and less mechanical stability. To summarize, LANd442 appeared suitable for low weight bearing bones but is inferior to LAE442 regarding its degradation morphology and strength. PMID:28824133

  3. Discovery of a Very Bright and Intrinsically Very Luminous, Strongly Lensed Lyα Emitting Galaxy at z = 2.82 in the BOSS Emission-Line Lens Survey

    NASA Astrophysics Data System (ADS)

    Marques-Chaves, Rui; Pérez-Fournon, Ismael; Shu, Yiping; Martínez-Navajas, Paloma I.; Bolton, Adam S.; Kochanek, Christopher S.; Oguri, Masamune; Zheng, Zheng; Mao, Shude; Montero-Dorta, Antonio D.; Cornachione, Matthew A.; Brownstein, Joel R.

    2017-01-01

    We report the discovery of a very bright (r = 20.16), highly magnified, and yet intrinsically very luminous Lyα emitter (LAE) at z=2.82. This system comprises four images in the observer plane with a maximum separation of ˜ 6\\prime\\prime and it is lensed by a z=0.55 massive early-type galaxy. It was initially identified in the Baryon Oscillation Spectroscopic Survey Emission-Line Lens Survey for GALaxy-Lyα EmitteR sYstems survey, and follow-up imaging and spectroscopic observations using the Gran Telescopio Canarias and William Herschel Telescope confirmed the lensing nature of this system. A lens model using a singular isothermal ellipsoid in an external shear field reproduces the main features of the system quite well, yielding an Einstein radius of 2.″95 ± 0.″10, and a total magnification factor for the LAE of 8.8 ± 0.4. This LAE is one of the brightest and most luminous galaxy-galaxy strong lenses known. We present initial imaging and spectroscopy showing the basic physical and morphological properties of this lensed system. Based on observations made with the Gran Telescopio Canarias (GTC) and William Herschel Telescope (WHT), in the Spanish Observatorio del Roque de los Muchachos of the IAC, under Directors Discretionary Time (DDT programs IDs: GTC2016-054 and DDT2016-077).

  4. Antimicrobial edible coatings and films from micro-emulsions and their food applications.

    PubMed

    Guo, Mingming; Yadav, Madhav P; Jin, Tony Z

    2017-12-18

    This study focused on the use of antimicrobial edible coatings and films from micro-emulsions to reduce populations of foodborne pathogens in foods. Corn-Bio-fiber gum (C-BFG) was used as an emulsifier with chitosan. Allyl isothiocyanate (AIT) and lauric arginate ester (LAE) served as antimicrobials. Micro-emulsions were obtained from a solution consisting of 1% chitosan, 0.5% C-BFG, and 1-4% AIT or LAE which was subject to high pressure homogenization (HPH) processing at 138MPa for 3cycles. Coatings and films produced from the micro-emulsions had micro-pores with sizes ranging from 100 to 300nm and micro-channels that hold antimicrobials effectively and facilitate the release of antimicrobials from the center to the surface of the films or coatings, thus enhancing their antimicrobial efficacy. The coatings and films with 1% AIT reduced populations of Listeria innocua by over 5, 2, and 3 log CFU in culture medium (Tryptic soy broth, TSB), ready-to-eat meat, and strawberries, respectively. The coatings and films with 1% LAE reduced populations of Escherichia coli O157:H7 and Salmonella spp. by over 5 and 2 log CFU in TSB and strawberries, respectively. This study provides an innovative approach for the development of effective antimicrobial materials to reduce food borne pathogenic contaminants on ready-to-eat meat, strawberries, or other food. Published by Elsevier B.V.

  5. A Faint Flux-limited Ly α Emitter Sample at z ∼ 0.3

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Wold, Isak G. B.; Finkelstein, Steven L.; Barger, Amy J.

    2017-10-20

    We present a flux-limited sample of z ∼ 0.3 Ly α emitters (LAEs) from Galaxy Evolution Explorer ( GALEX ) grism spectroscopic data. The published GALEX z ∼ 0.3 LAE sample is pre-selected from continuum-bright objects and thus is biased against high equivalent width (EW) LAEs. We remove this continuum pre-selection and compute the EW distribution and the luminosity function of the Ly α emission line directly from our sample. We examine the evolution of these quantities from z ∼ 0.3 to 2.2 and find that the EW distribution shows little evidence for evolution over this redshift range. As shownmore » by previous studies, the Ly α luminosity density from star-forming (SF) galaxies declines rapidly with declining redshift. However, we find that the decline in Ly α luminosity density from z = 2.2 to z = 0.3 may simply mirror the decline seen in the H α luminosity density from z = 2.2 to z = 0.4, implying little change in the volumetric Ly α escape fraction. Finally, we show that the observed Ly α luminosity density from AGNs is comparable to the observed Ly α luminosity density from SF galaxies at z = 0.3. We suggest that this significant contribution from AGNs to the total observed Ly α luminosity density persists out to z ∼ 2.2.« less

  6. The impact of Lyman-α radiative transfer on large-scale clustering in the Illustris simulation

    NASA Astrophysics Data System (ADS)

    Behrens, C.; Byrohl, C.; Saito, S.; Niemeyer, J. C.

    2018-06-01

    Context. Lyman-α emitters (LAEs) are a promising probe of the large-scale structure at high redshift, z ≳ 2. In particular, the Hobby-Eberly Telescope Dark Energy Experiment aims at observing LAEs at 1.9 < z < 3.5 to measure the baryon acoustic oscillation (BAO) scale and the redshift-space distortion (RSD). However, it has been pointed out that the complicated radiative transfer (RT) of the resonant Lyman-α emission line generates an anisotropic selection bias in the LAE clustering on large scales, s ≳ 10 Mpc. This effect could potentially induce a systematic error in the BAO and RSD measurements. Also, there exists a recent claim to have observational evidence of the effect in the Lyman-α intensity map, albeit statistically insignificant. Aims: We aim at quantifying the impact of the Lyman-α RT on the large-scale galaxy clustering in detail. For this purpose, we study the correlations between the large-scale environment and the ratio of an apparent Lyman-α luminosity to an intrinsic one, which we call the "observed fraction", at 2 < z < 6. Methods: We apply our Lyman-α RT code by post-processing the full Illustris simulations. We simply assume that the intrinsic luminosity of the Lyman-α emission is proportional to the star formation rate of galaxies in Illustris, yielding a sufficiently large sample of LAEs to measure the anisotropic selection bias. Results: We find little correlation between large-scale environment and the observed fraction induced by the RT, and hence a smaller anisotropic selection bias than has previously been claimed. We argue that the anisotropy was overestimated in previous work due to insufficient spatial resolution; it is important to keep the resolution such that it resolves the high-density region down to the scale of the interstellar medium, that is, 1 physical kpc. We also find that the correlation can be further enhanced by assumptions in modeling intrinsic Lyman-α emission.

  7. Probing the Metal Enrichment of the Intergalactic Medium at z = 5–6 Using the Hubble Space Telescope

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Cai, Zheng; Fan, Xiaohui; Dave, Romeel

    We test the galactic outflow model by probing associated galaxies of four strong intergalactic C iv absorbers at z = 5–6 using the Hubble Space Telescope ( HST ) Advanced Camera for Surveys (ACS) ramp narrowband filters. The four strong C iv absorbers reside at z = 5.74, 5.52, 4.95, and 4.87, with column densities ranging from N {sub Civ} = 10{sup 13.8} to 10{sup 14.8} cm{sup −2}. At z = 5.74, we detect an i-dropout Ly α emitter (LAE) candidate with a projected impact parameter of 42 physical kpc from the C iv absorber. This LAE candidate has amore » Ly α -based star formation rate (SFR{sub Lyα} ) of 2 M {sub ⊙} yr{sup −1} and a UV-based SFR of 4 M {sub ⊙} yr{sup −1}. Although we cannot completely rule out that this i-dropout emitter may be an [O ii] interloper, its measured properties are consistent with the C iv powered galaxy at z = 5.74. For C iv absorbers at z = 4.95 and z = 4.87, although we detect two LAE candidates with impact parameters of 160 and 200 kpc, such distances are larger than that predicted from the simulations. Therefore, we treat them as nondetections. For the system at z = 5.52, we do not detect LAE candidates, placing a 3 σ upper limit of SFR{sub Lyα} ≈ 1.5 M {sub ⊙} yr{sup −1}. In summary, in these four cases, we only detect one plausible C iv source at z = 5.74. Combining the modest SFR of the one detection and the three nondetections, our HST observations strongly support that smaller galaxies (SFR{sub Lyα} ≲ 2 M {sub ⊙} yr{sup −1}) are main sources of intergalactic C iv absorbers, and such small galaxies play a major role in the metal enrichment of the intergalactic medium at z ≳ 5.« less

  8. Defining treatment conditions for pulsed electric field pasteurization of apple juice.

    PubMed

    Saldaña, G; Puértolas, E; Monfort, S; Raso, J; Alvarez, I

    2011-11-15

    The influence of temperature and the presence of N(α)-lauroyl ethylester (ethyl lauroyl arginate, LAE) on the inactivation caused by continuous pulsed electric field treatments (PEF) in Escherichia coli O157:H7 suspended in apple juice have been investigated to define treatment conditions applicable at industrial scale that promote an equivalent safety level when compared with thermal processing. In the range of experimental conditions investigated (outlet temperature: 20-40 °C, electric field strength: 20-30 kV, treatment time: 5-125 μs) at outlet temperatures equal or lower than 55±1 °C, the inactivation of E. coli O157:H7 treated in apple juice ranged from 0.4 to 3.6 Log₁₀ cycles reduction and treated in apple juice supplemented with LAE (50 ppm) ranged from 0.9 to 6.7 Log₁₀ cycles reduction. An empirical mathematical model was developed to estimate the treatment time and total specific energy input to obtain 5 Log₁₀ cycles reduction in the population of E. coli O157:H7 suspended in apple juice supplemented with 50 ppm of LAE at different electric field strengths and inlet temperatures. Treatment conditions established for E. coli O157:H7 were validated with other PEF resistant Gram-positive (Listeria monocytogenes, and Staphylococcus aureus) and Gram-negative (Salmonella enterica serovar Typhimurium) strains. When the treatment was applied to the apple juice, a treatment of 25 kV/cm for 63 μs corresponding with an outlet temperature of 65 °C and input energy of 125 kJ/kg was required to achieve more than 5 Log₁₀ cycles in the four strains investigated. The addition of LAE reduced the treatment time required to obtain an equivalent inactivation (>5 Log₁₀ cycles) in the four microorganisms to 38.4 μs, the outlet temperature to 55 °C, and the input energy to 83.2 kJ/kg. Copyright © 2011 Elsevier B.V. All rights reserved.

  9. SILVERRUSH. IV. Lyα luminosity functions at z = 5.7 and 6.6 studied with ˜1300 Lyα emitters on the 14-21 deg2 sky

    NASA Astrophysics Data System (ADS)

    Konno, Akira; Ouchi, Masami; Shibuya, Takatoshi; Ono, Yoshiaki; Shimasaku, Kazuhiro; Taniguchi, Yoshiaki; Nagao, Tohru; Kobayashi, Masakazu A. R.; Kajisawa, Masaru; Kashikawa, Nobunari; Inoue, Akio K.; Oguri, Masamune; Furusawa, Hisanori; Goto, Tomotsugu; Harikane, Yuichi; Higuchi, Ryo; Komiyama, Yutaka; Kusakabe, Haruka; Miyazaki, Satoshi; Nakajima, Kimihiko; Wang, Shiang-Yu

    2018-01-01

    We present the Lyα luminosity functions (LFs) at z = 5.7 and 6.6 derived from a new large sample of 1266 Lyα emitters (LAEs) identified in total areas of 14 and 21 deg2, respectively, based on the early narrowband data of the Subaru/Hyper Suprime-Cam survey. Together with careful Monte Carlo simulations that account for the incompleteness of the LAE selection and the flux estimate systematics in the narrowband imaging, we have determined the Lyα LFs with unprecedentedly small statistical and systematic uncertainties in a wide Lyα luminosity range of 1042.8-43.8 erg s-1. We obtain best-fit Schechter parameters of L^{*}_{Lyα } = 1.6^{+2.2}_{-0.6} (1.7^{+0.3}_{-0.7}) × 10^{43}ergs^{-1}, φ ^{*}_{Lyα } = 0.85^{+1.87}_{-0.77} (0.47^{+1.44}_{-0.44}) × 10^{-4}Mpc^{-3}, and α = -2.6^{+0.6}_{-0.4} (-2.5^{+0.5}_{-0.5}) at z = 5.7 (6.6). We confirm that our best-estimate Lyα LFs are consistent with the majority of the previous studies, but find that our Lyα LFs do not agree with the high number densities of LAEs recently claimed by Matthee/Santos et al.'s studies that may overcorrect the incompleteness and the flux systematics. Our Lyα LFs at z = 5.7 and 6.6 show an indication that the faint-end slope is very steep (α ≃ -2.5), although it is also possible that the bright-end LF results are enhanced by systematic effects such as the contribution from AGNs, blended merging galaxies, and/or large ionized bubbles around bright LAEs. Comparing our Lyα LF measurements with four independent reionization models, we estimate the neutral hydrogen fraction of the intergalactic medium to be x_{H I} = 0.3 ± 0.2 at z = 6.6, which is consistent with the small Thomson scattering optical depth obtained by Planck 2016.

  10. Accelerated evolution of the Lyα luminosity function at z ≳ 7 revealed by the Subaru ultra-deep survey for Lyα emitters at z = 7.3

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Konno, Akira; Ouchi, Masami; Ono, Yoshiaki

    2014-12-10

    We present the ultra-deep Subaru narrowband imaging survey for Lyα emitters (LAEs) at z = 7.3 in the Subaru/XMM-Newton Deep Survey (SXDS) and Cosmic Evolution Survey (COSMOS) fields (∼0.5 deg{sup 2}) with a total integration time of 106 hr. Exploiting our new sharp bandwidth filter, NB101, installed on the Suprime-Cam, we have reached L(Lyα) = 2.4 × 10{sup 42} erg s{sup –1} (5σ) for z = 7.3 LAEs, about four times deeper than previous Subaru z ≳ 7 studies, which allows us to reliably investigate the evolution of the Lyα luminosity function (LF) for the first time down to themore » luminosity limit same as those of Subaru z = 3.1-6.6 LAE samples. Surprisingly, we only find three and four LAEs in the SXDS and COSMOS fields, respectively, while one expects a total of ∼65 LAEs by our survey in the case of no Lyα LF evolution from z = 6.6 to 7.3. We identify a decrease of the Lyα LF from z = 6.6 to 7.3 at the >90% confidence level from our z = 7.3 Lyα LF with the best-fit Schechter parameters of L{sub Lyα}{sup ∗}=2.7{sub −1.2}{sup +8.0}×10{sup 42} erg s{sup −1} and ϕ{sup ∗}=3.7{sub −3.3}{sup +17.6}×10{sup −4} Mpc{sup −3} for a fixed α = –1.5. Moreover, the evolution of the Lyα LF is clearly accelerated at z > 6.6 beyond the measurement uncertainties including cosmic variance. Because no such accelerated evolution of the UV-continuum LF or the cosmic star formation rate (SFR) is found at z ∼ 7, but suggested only at z > 8, this accelerated Lyα LF evolution is explained by physical mechanisms different from a pure SFR decrease but related to the Lyα production and escape in the process of cosmic reionization. Because a simple accelerating increase of intergalactic medium neutral hydrogen absorbing Lyα cannot be reconciled with Thomson scattering of optical depth measurements from WMAP and Planck, our findings may support new physical pictures suggested by recent theoretical studies, such as the existence of HI clumpy clouds

  11. Effect of methergoline on body temperature in mice.

    PubMed

    Cardano, C; Strocchi, P; Gonni, D; Walsh, M; Agnati, L F

    1977-03-01

    Serotonin (5-HT) involvement in body temperature regulation has been studied in mice by means of a 5-HT-selective blocking agent (methergoline). This drug causes an effect on body temperature which is dependent on environmental temperature. At environmental temperatures of 25 degrees C and 11 degrees C methergoline has a hypothermic effect, while at 36 degrees C environmental temperature, methergoline has a hyperthermic effect. At 25 degrees C environmental temperature, the hypothermic effect induced by 125 mug/kg i.p. of methergoline could be antagonized by low doses of LAE-32 (80 mug/kg s.c.), while there was not such an antagonism using higher doses of LAE-32 (100 and 300 mug/kg s.c.). This has been explained using Jalfre's hypothesis of the existence of 5-HT inhibitory and excitatory receptors.

  12. Detection of Steel Fatigue Cracks with Strain Sensing Sheets Based on Large Area Electronics

    PubMed Central

    Yao, Yao; Glisic, Branko

    2015-01-01

    Reliable early-stage damage detection requires continuous monitoring over large areas of structure, and with sensors of high spatial resolution. Technologies based on Large Area Electronics (LAE) can enable direct sensing and can be scaled to the level required for Structural Health Monitoring (SHM) of civil structures and infrastructure. Sensing sheets based on LAE contain dense arrangements of thin-film strain sensors, associated electronics and various control circuits deposited and integrated on a flexible polyimide substrate that can cover large areas of structures. This paper presents the development stage of a prototype strain sensing sheet based on LAE for crack detection and localization. Two types of sensing-sheet arrangements with size 6 × 6 inch (152 × 152 mm) were designed and manufactured, one with a very dense arrangement of sensors and the other with a less dense arrangement of sensors. The sensing sheets were bonded to steel plates, which had a notch on the boundary, so the fatigue cracks could be generated under cyclic loading. The sensors within the sensing sheet that were close to the notch tip successfully detected the initialization of fatigue crack and localized the damage on the plate. The sensors that were away from the crack successfully detected the propagation of fatigue cracks based on the time history of the measured strain. The results of the tests have validated the general principles of the proposed sensing sheets for crack detection and identified advantages and challenges of the two tested designs. PMID:25853407

  13. Thermodynamic characteristics of a novel wind-solar-liquid air energy storage system

    NASA Astrophysics Data System (ADS)

    Ji, W.; Zhou, Y.; Sun, Y.; Zhang, W.; Pan, C. Z.; Wang, J. J.

    2017-12-01

    Due to the nature of fluctuation and intermittency, the utilization of wind and solar power will bring a huge impact to the power grid management. Therefore a novel hybrid wind-solar-liquid air energy storage (WS-LAES) system was proposed. In this system, wind and solar power are stored in the form of liquid air by cryogenic liquefaction technology and thermal energy by solar thermal collector, respectively. Owing to the high density of liquid air, the system has a large storage capacity and no geographic constraints. The WS-LAES system can store unstable wind and solar power for a stable output of electric energy and hot water. Moreover, a thermodynamic analysis was carried out to investigate the best system performance. The result shows that the increases of compressor adiabatic efficiency, turbine inlet pressure and inlet temperature all have a beneficial effect.

  14. A New Constraint on Reionization from the Evolution of the Lyα Luminosity Function at z ˜ 6-7 Probed by a Deep Census of z = 7.0 Lyα Emitter Candidates to 0.3L *

    NASA Astrophysics Data System (ADS)

    Ota, Kazuaki; Iye, Masanori; Kashikawa, Nobunari; Konno, Akira; Nakata, Fumiaki; Totani, Tomonori; Kobayashi, Masakazu A. R.; Fudamoto, Yoshinobu; Seko, Akifumi; Toshikawa, Jun; Ichikawa, Akie; Shibuya, Takatoshi; Onoue, Masafusa

    2017-07-01

    We detect 20 z = 7.0 Lyα emitter (LAE) candidates to L(Lyα) ˜ 2 × 1042 erg s-1 or 0.3 {L}z=7* and in a volume of 6.1 × 105 Mpc3 in the Subaru Deep Field and the Subaru/XMM-Newton Deep Survey field by 82 hr and 37 hr of Subaru Suprime-Cam narrowband NB973 and reddest optical y-band imaging. We compare their Lyα and UV luminosity functions (LFs) and densities and Lyα equivalent widths (EWs) to those of z = 5.7, 6.6, and 7.3 LAEs from previous Suprime-Cam surveys. The Lyα LF (density) rapidly declines by a factor of ×1.5 (1.9) in L(Lyα) at z = 5.7-6.6 (160 Myr), ×1.5 (1.6) at z = 6.6-7.0 (60 Myr) at the faint end, and ×2.0 (3.8) at z = 7.0-7.3 (40 Myr). Also, in addition to the systematic decrease in EW at z = 5.7-6.6 previously found, two-thirds of the z = 7.0 LAEs detected in the UV continuum exhibit lower EWs than the z = 6.6 ones. Moreover, while the UV LF and density do not evolve at z = 5.7-6.6, they modestly decline at z = 6.6-7.0, implying galaxy evolution contributing to the decline of the Lyα LF. Comparison of the z = 7.0 Lyα LF to the one predicted by an LAE evolution model further reveals that galaxy evolution alone cannot explain all of the decline of the Lyα LF. If we attribute the discrepancy to Lyα attenuation by neutral hydrogen, the intergalactic medium transmission of Lyα photons at z = 7.0 would be {T}{Lyα }{IGM}≤slant 0.6{--}0.7. It is lower (higher) than the {T}{Lyα }{IGM} at z = 6.6 (7.3) derived by previous studies, suggesting rapid increase in neutral fraction at z > 6. Based on data collected at Subaru Telescope, which is operated by the National Astronomical Observatory of Japan.

  15. Evaluation of USDA approved antimicrobials on the reduction of Salmonella and Campylobacter in ground chicken frames and their effect on meat quality.

    PubMed

    Moore, A; Nannapaneni, R; Kiess, A; Sharma, C S

    2017-07-01

    The main objective of this study was to examine the efficacy of USDA approved antimicrobials in reducing Salmonella Heidelberg (S. H.) and Campylobacter jejuni (C. j.) in ground chicken frames and to determine the treatment effects on total aerobic counts and meat color. Six antimicrobials (0.1% peracetic acid [PAA], 0.6% cetylpyridinium chloride [CPC], 0.005% sodium hypochlorite, 1.5% acidified lactic acid [ALA], 0.3% propionic acid, and 0.1% lauric arginate [LAE]) applied as dip treatments were evaluated in their efficacy in reducing S. Heidelberg and C. jejuni. Fresh chicken frames were spot inoculated with nalidixic acid resistant S. H. and C. j. (ATCC 33291) to achieve a recovery level of ca. 3 log CFU/g in the ground product. Frames were dipped for 10 s in each antimicrobial solution and each treatment was replicated on 3 frames. Three separate replications were conducted for this experiment. Frames were blended, and ground samples similar to mechanically separated chicken (MSC) were obtained and stored at 4°C for 24 hours. Samples were analyzed after grinding on d zero (2 h) and d one (24 h) to determine reduction in S. H. and C. j. counts in MSC. PAA and LAE treatments had the highest reductions on Salmonella counts (P ≤ 0.05), both treatments resulting in 0.9 log CFU/g reduction as compared to control on d zero. PAA and CPC reduced Salmonella counts by 1.4 and 0.9 log CFU/g, respectively, on d one; PAA, propionic acid, ALA, and LAE resulted in one log CFU/g reductions of C. j. as compared to control on d one. There was no significant difference among the treatments in their ability to reduce C. j. on d one. The treatments had no effect on total aerobic counts. The findings from the study indicate that PAA, CPC, and LAE can reduce S. H. in ground chicken frames, whereas all the antimicrobials tested in the study, except chlorine, have the ability to reduce C. j. in ground chicken frames, a product similar to commercial MSC. © 2017 Poultry Science

  16. The mean ultraviolet spectrum of a representative sample of faint z ˜ 3 Lyman alpha emitters

    NASA Astrophysics Data System (ADS)

    Nakajima, Kimihiko; Fletcher, Thomas; Ellis, Richard S.; Robertson, Brant E.; Iwata, Ikuru

    2018-06-01

    We discuss the rest-frame ultraviolet (UV) emission line spectra of a large (˜100) sample of low luminosity redshift z ˜ 3.1 Lyman alpha emitters (LAEs) drawn from a Subaru imaging survey in the SSA22 survey field. Our earlier work based on smaller samples indicated that such sources have high [O III]/[O II] line ratios possibly arising from a hard ionizing spectrum that may be typical of similar sources in the reionization era. With optical spectra secured from VLT/VIMOS, we re-examine the nature of the ionizing radiation in a larger sample using the strength of the high ionization diagnostic emission lines of CIII]λ1909, CIVλ1549, HEIIλ1640, and O III]λλ1661, 1666 Å in various stacked subsets. Our analysis confirms earlier suggestions of a correlation between the strength of Ly α and CIII] emission and we find similar trends with broad-band UV luminosity and rest-frame UV colour. Using various diagnostic line ratios and our stellar photoionization models, we determine both the gas phase metallicity and hardness of the ionization spectrum characterized by ξion - the number of Lyman continuum photons per UV luminosity. We confirm our earlier suggestion that ξion is significantly larger for LAEs than for continuum-selected Lyman break galaxies, particularly for those LAEs with the faintest UV luminosities. We briefly discuss the implications for cosmic reionization if the metal-poor intensely star-forming systems studied here are representative examples of those at much higher redshift.

  17. Health promotion and information provision during long-term follow-up for childhood cancer survivors: A service evaluation.

    PubMed

    Mayes, Jonathan; Brown, Morven C; Davies, Nicola; Skinner, Roderick

    2016-09-01

    Health promotion is an important component of long-term follow-up (LTFU) care for childhood cancer survivors (CCS). However, little information exists about how survivors perceive their own health promotion needs. As part of a service evaluation, 51 CCS who had previously attended the LTFU clinic took part in a single semistructured interview to seek their views on information they had received regarding late adverse effects (LAEs) of treatment, the purpose of LTFU, and the provision of health promotion information. Although most (93%) CCS were satisfied with the information received about LAEs, 37% desired further details. Over half (59%) believed that the purpose of LTFU was to screen for LAEs, whereas 31% felt that it was to check for relapse. No survivor reported health promotion to be an aim of LTFU; only 14% of CCS expected to receive healthy lifestyle advice, and fewer than 10% wanted dietary and physical activity advice. Most (88%) CCS felt that their hospital-based health care professional was best placed to give healthy lifestyle advice, but there was no consensus about the optimum timing for health promotion. CCS varied in their knowledge, needs, and wishes regarding LTFU care. The results of this evaluation strongly indicate that the profile of health promotion needs to be raised within our service and identifies issues that may be pertinent to similar services. Further research is needed to understand the views of CCS regarding health promotion and lifestyle behaviors, with the aim of tailoring and improving the delivery of effective health education to CCS.

  18. Technostress and the Reference Librarian.

    ERIC Educational Resources Information Center

    Kupersmith, John

    1992-01-01

    Defines "technostress" as the stress experienced by reference librarians who must constantly deal with the demands of new information technology and the changes they produce in the work place. Discussion includes suggested ways in which both organizations and individuals can work to reduce stress. (27 references) (LAE)

  19. The Half-circled "C": Canadian Copyright Legislation.

    ERIC Educational Resources Information Center

    Hansen, Linda

    1992-01-01

    Reviews the legislative history of Canadian copyright law, especially with respect to government documents. Briefly describes the British origins of Canadian copyright, the British North America Act (1867), and the Copyright Act of 1921, all of which serve as background to the current law. (111 references) (LAE)

  20. Antimicrobial edible coatings and films from micro-emulsions and their food applications

    USDA-ARS?s Scientific Manuscript database

    This study focused on the use of antimicrobial edible coatings and films from micro-emulsions to reduce populations of foodborne pathogens in foods. Corn-Bio-fiber gum (C-BFG) was used as an emulsifier with chitosan. Allyl isothiocyanate (AIT) and lauric arginate ester (LAE) served as antimicrobials...

  1. Acoustic energy propagation around railways

    NASA Astrophysics Data System (ADS)

    Cizkova, Petra

    2017-09-01

    The article deals with the issues of acoustic energy propagation around railways. The research subject was noise emission spreading into the surroundings during the passage of trains over a directly travelled steel bridge construction. Noise emissions were measured using direct measurements in the field. The measurements were performed in two measurement profiles. The noise exposures A LAE measured near the steel bridge construction were compared against the noise exposures A LAE captured on an open track. From the difference of these data, the noise level of the steel bridge structure was determined. Part of the research was to evaluate the effect of the reconstruction of the railway track superstructure on the acoustic situation in the given section of the railway track. The article describes the methodology of measurements, including the processing and evaluation of measured data. The article points out the noise levels of the steel bridge construction and assesses changes in the acoustic situation after the reconstruction.

  2. Antimicrobial polylactic acid packaging films against Listeria and Salmonella in culture medium and on ready-to-eat meat

    USDA-ARS?s Scientific Manuscript database

    The contamination of Listeria monocytogenes and Salmonella spp. in ready-to-eat (RTE) meat products has been a concern for the meat industry. In this study, edible chitosan-acid solutions incorporating lauric arginate ester (LAE), sodium lactate (NaL) and sorbic acid (SA) alone or in combinations we...

  3. Go Figure: Computer Database Adds the Personal Touch.

    ERIC Educational Resources Information Center

    Gaffney, Jean; Crawford, Pat

    1992-01-01

    A database for recordkeeping for a summer reading club was developed for a public library system using an IBM PC and Microsoft Works. Use of the database resulted in more efficient program management, giving librarians more time to spend with patrons and enabling timely awarding of incentives. (LAE)

  4. On the Decreasing Fraction of Strong Ly α Emitters around z ∼ 6-7

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Sadoun, Raphael; Zheng, Zheng; Miralda-Escudé, Jordi, E-mail: raphael.sadoun@utah.edu

    2017-04-10

    The fraction of galaxies with strong Ly α emission has been observed to decrease rapidly with redshift at z ≳ 6, after a gradual increase at z < 6. This has been interpreted as being a trace of the reionization of the intergalactic medium (IGM): the emitted Ly α photons would be scattered by an increasingly neutral IGM at z > 6. We study this effect by modeling the ionization and Ly α radiative transfer in the infall region and the IGM around a Ly α emitting galaxy (LAE), for a spherical halo model with the mean density and radialmore » velocity profiles in the standard ΛCDM cosmological scenario. We find that the expected fast increase of the ionizing background intensity toward the end of the reionization epoch implies a rapid evolution of halo infall regions from being self-shielded against the external ionizing background to being mostly ionized. Whereas self-shielded infall regions can scatter the Ly α photons over a much larger area than the commonly used apertures for observing LAEs, the same infalling gas is no longer optically thick to the Ly α emission line after it is ionized by the external background, making the Ly α emission more compact and brighter within the observed apertures. Based on this simple model, we show that the observed drop in the abundance of LAEs at z > 6 does not imply a rapid increase with redshift of the fraction of the whole IGM volume that is atomic, but is accounted for by a rapid increase of the neutral fraction in the infall regions around galaxy host halos.« less

  5. The Left Atrio-Vertebral Ratio: a new simple means for assessing left atrial enlargement on Computed Tomography.

    PubMed

    Montillet, Marie; Baqué-Juston, Marie; Tasu, Jean-Pierre; Bertrand, Sandra; Berthier, Frédéric; Zarqane, Naïma; Brunner, Philippe

    2018-03-01

    The purpose of this study is to describe a new method to quickly estimate left atrial enlargement (LAE) on Computed Tomography. Left atrial (LA) volume was assessed with a 3D-threshold Hounsfield unit detection technique, including left atrial appendage and excluding pulmonary venous confluence, in 201 patients with ECG-gated 128-slice dual-source CT and indexed to body surface area. LA and vertebral axial diameter and area were measured at the bottom level of the right inferior pulmonary vein ostium. Ratio of LA diameter and surface on vertebra (LAVD and LAVA) were compared to LA volume. In accordance with the literature, a cutoff value of 78 ml/m 2 was chosen for maximal normal LA volume. 18% of LA was enlarged. The best cutoff values for LAE assessment were 2.5 for LAVD (AUC: 0.65; 95% CI: 0.58-0.73; sensitivity: 57%; specificity: 71%), and 3 for LAVA (AUC: 0.78; 95% CI: 0.72-0.84; sensitivity: 67%; specificity: 79%), with higher accuracy for LAVA (P=0.015). Inter-observer and intra-observer variability were either good or excellent for LAVD and LAVA (respective intraclass coefficients: 0.792 and 0.910; 0.912 and 0.937). A left atrium area superior to three times the vertebral area indicates LAE with high specificity. • Left atrial enlargement is a frequent condition associated with poor cardiac outcome. • Left atrial enlargement is highly time-consuming to diagnose on CT. • The left atrio-vertebral ratio quickly assesses left atrial enlargement. • A left atrial area > three times vertebral area is highly specific.

  6. A Faint Flux-limited Lyα Emitter Sample at z ˜ 0.3

    NASA Astrophysics Data System (ADS)

    Wold, Isak G. B.; Finkelstein, Steven L.; Barger, Amy J.; Cowie, Lennox L.; Rosenwasser, Benjamin

    2017-10-01

    We present a flux-limited sample of z ˜ 0.3 Lyα emitters (LAEs) from Galaxy Evolution Explorer (GALEX) grism spectroscopic data. The published GALEX z ˜ 0.3 LAE sample is pre-selected from continuum-bright objects and thus is biased against high equivalent width (EW) LAEs. We remove this continuum pre-selection and compute the EW distribution and the luminosity function of the Lyα emission line directly from our sample. We examine the evolution of these quantities from z ˜ 0.3 to 2.2 and find that the EW distribution shows little evidence for evolution over this redshift range. As shown by previous studies, the Lyα luminosity density from star-forming (SF) galaxies declines rapidly with declining redshift. However, we find that the decline in Lyα luminosity density from z = 2.2 to z = 0.3 may simply mirror the decline seen in the Hα luminosity density from z = 2.2 to z = 0.4, implying little change in the volumetric Lyα escape fraction. Finally, we show that the observed Lyα luminosity density from AGNs is comparable to the observed Lyα luminosity density from SF galaxies at z = 0.3. We suggest that this significant contribution from AGNs to the total observed Lyα luminosity density persists out to z ˜ 2.2. Some of the data presented herein were obtained at the W.M. Keck Observatory, which is operated as a scientific partnership among the California Institute of Technology, the University of California, and the National Aeronautics and Space Administration. The Observatory was made possible by the generous financial support of the W.M. Keck Foundation.

  7. Physical Properties of Spectroscopically Confirmed Galaxies at z >= 6. I. Basic Characteristics of the Rest-frame UV Continuum and Lyα Emission

    NASA Astrophysics Data System (ADS)

    Jiang, Linhua; Egami, Eiichi; Mechtley, Matthew; Fan, Xiaohui; Cohen, Seth H.; Windhorst, Rogier A.; Davé, Romeel; Finlator, Kristian; Kashikawa, Nobunari; Ouchi, Masami; Shimasaku, Kazuhiro

    2013-08-01

    We present deep Hubble Space Telescope near-IR and Spitzer mid-IR observations of a large sample of spectroscopically confirmed galaxies at z >= 6. The sample consists of 51 Lyα emitters (LAEs) at z ~= 5.7, 6.5, and 7.0, and 16 Lyman break galaxies (LBGs) at 5.9 <= z <= 6.5. The near-IR images were mostly obtained with WFC3 in the F125W and F160W bands, and the mid-IR images were obtained with IRAC in the 3.6 μm and 4.5 μm bands. Our galaxies also have deep optical imaging data from Subaru Suprime-Cam. We utilize the multi-band data and secure redshifts to derive their rest-frame UV properties. These galaxies have steep UV-continuum slopes roughly between β ~= -1.5 and -3.5, with an average value of β ~= -2.3, slightly steeper than the slopes of LBGs in previous studies. The slope shows little dependence on UV-continuum luminosity except for a few of the brightest galaxies. We find a statistically significant excess of galaxies with slopes around β ~= -3, suggesting the existence of very young stellar populations with extremely low metallicity and dust content. Our galaxies have moderately strong rest-frame Lyα equivalent width (EW) in a range of ~10 to ~200 Å. The star formation rates are also moderate, from a few to a few tens of solar masses per year. The LAEs and LBGs in this sample share many common properties, implying that LAEs represent a subset of LBGs with strong Lyα emission. Finally, the comparison of the UV luminosity functions between LAEs and LBGs suggests that there exists a substantial population of faint galaxies with weak Lyα emission (EW < 20 Å) that could be the dominant contribution to the total ionizing flux at z >= 6. Based in part on observations made with the NASA/ESA Hubble Space Telescope, obtained from the data archive at the Space Telescope Science Institute, which is operated by the Association of Universities for Research in Astronomy, Inc. under NASA contract NAS 5-26555. Based in part on observations made with the

  8. Services of the Central Education Library of the Peel Board of Education Serving Graduates at Brock University and the Extension Campus of the Ontario Institute of Studies in Education: A Survey.

    ERIC Educational Resources Information Center

    Wilkins, Catherine E.

    1992-01-01

    Assesses the resources and services of the Central Education Library of the Peel Board of Education through a survey of the views and opinions of its two primary user groups: (1) members of the Peel Board of Education, and (2) faculty in graduate education programs in Ontario. (19 references) (LAE)

  9. Trapped in a Local History: Why Did Extramural Fail to Engage in the Era of Engagement?

    ERIC Educational Resources Information Center

    Duke, Chris

    2008-01-01

    Extramural liberal adult education (LAE), as conceived in the particular UK tradition, was doomed by its high-minded origins and its privileged status, and contributed little to the new concepts of "éducation permanente," lifelong learning, the knowledge society, the learning society and region, or to the new understandings of university…

  10. The American Archival Profession and Information Technology Standards.

    ERIC Educational Resources Information Center

    Cox, Richard J.

    1992-01-01

    Discussion of the use of standards by archivists highlights the U.S. MARC AMC (Archives-Manuscript Control) format for reporting archival records and manuscripts; their interest in specific standards being developed for the OSI (Open Systems Interconnection) reference model; and the management of records in electronic formats. (16 references) (LAE)

  11. Aspergillus flavus VelB acts distinctly from VeA in conidiation and may coordinate with FluG to modulate sclerotial production

    USDA-ARS?s Scientific Manuscript database

    Asexual and sexual differentiation in Aspergillus nidulans involve complex control by a number of factors and is light-dependent. The velvet protein, VeA, in A. nidulans is a negative regulator of conidiation and a positive regulator of sexual development. It forms a complex with VelB and LaeA to co...

  12. Why Do We Study the History of Libraries? A Meditation on the Perils of Ahistoricism in the Information Era.

    ERIC Educational Resources Information Center

    Harris, Michael H.; Hannah, Stanley

    1992-01-01

    This review of the literature responds to Daniel Bell, F. W. Lancaster, and others who have predicted the end of the library with the coming of the postindustrial, "paperless" society. Highlights include discussions of librarians as cultural custodians and the importance of the library in the history of civilization. (35 references) (LAE)

  13. Evolution of the observed Lyα luminosity function from z = 6.5 to z = 7.7: evidence for the epoch of reionization?

    NASA Astrophysics Data System (ADS)

    Clément, B.; Cuby, J.-G.; Courbin, F.; Fontana, A.; Freudling, W.; Fynbo, J.; Gallego, J.; Hibon, P.; Kneib, J.-P.; Le Fèvre, O.; Lidman, C.; McMahon, R.; Milvang-Jensen, B.; Moller, P.; Moorwood, A.; Nilsson, K. K.; Pentericci, L.; Venemans, B.; Villar, V.; Willis, J.

    2012-02-01

    Aims: Lyα emitters (LAEs) can be detected out to very high redshifts during the epoch of reionization. The evolution of the LAE luminosity function with redshift is a direct probe of the Lyα transmission of the intergalactic medium (IGM), and therefore of the IGM neutral-hydrogen fraction. Measuring the Lyα luminosity function (LF) of Lyα emitters at redshift z = 7.7 therefore allows us to constrain the ionizing state of the Universe at this redshift. Methods: We observed three 7'.5 × 7'.5 fields with the HAWK-I instrument at the VLT with a narrow band filter centred at 1.06 μm and targeting Lyα emitters at redshift z ~ 7.7. The fields were chosen for the availability of multiwavelength data. One field is a galaxy cluster, the Bullet Cluster, which allowed us to use gravitational amplification to probe luminosities that are fainter than in the field. The two other fields are subareas of the GOODS Chandra Deep Field South and CFHTLS-D4 deep field. We selected z = 7.7 LAE candidates from a variety of colour criteria, in particular from the absence of detection in the optical bands. Results: We do not find any LAE candidates at z = 7.7 in ~2.4 × 104 Mpc3 down to a narrow band AB magnitude of ~26, which allows us to infer robust constraints on the Lyα LAE luminosity function at this redshift. Conclusions: The predicted mean number of objects at z = 6.5, derived from somewhat different luminosity functions of Hu et al. (2010, ApJ, 725, 394), Ouchi et al. (2010, ApJ, 723, 869), and Kashikawa et al. (2011, ApJ, 734, 119) are 2.5, 13.7, and 11.6, respectively. Depending on which of these luminosity functions we refer to, we exclude a scenario with no evolution from z = 6.5 to z = 7.7 at 85% confidence without requiring a strong change in the IGM Lyα transmission, or at 99% confidence with a significant quenching of the IGM Lyα transmission, possibly from a strong increase in the high neutral-hydrogen fraction between these two redshifts. Based on observations

  14. The Relationship Between Stellar Populations and Lyα Emission in Lyman Break Galaxies

    NASA Astrophysics Data System (ADS)

    Kornei, Katherine; Shapley, A. E.; Erb, D. K.; Steidel, C. C.; Reddy, N. A.; Pettini, M.; Bogosavljevic, M.

    2010-01-01

    We present the results of a photometric and spectroscopic survey of 321 Lyman break galaxies (LBGs) at z ˜ 3 to investigate systematically the relationship between Lyα emission and stellar populations. Lyα equivalent widths (EWs) were calculated from rest-frame UV spectroscopy and optical/near-infrared/Spitzer photometry was used in population synthesis modeling to derive the key properties of age, dust extinction, star formation rate (SFR), and stellar mass. We directly compare the stellar populations of LBGs with and without strong Lyα emission, where we designate the former group (EW ≥ 20 angstroms) as Lyα-emitters (LAEs) and the latter group (EW < 20 angstroms) as non-LAEs. This controlled method of comparing objects from the same UV luminosity distribution represents an improvement over previous studies in which the stellar populations of LBGs and narrowband-selected LAEs were contrasted, where the latter were often intrinsically fainter in broadband filters by an order of magnitude simply due to different selection criteria. Using a variety of statistical tests, we find that Lyα equivalent width and age, SFR, and dust extinction, respectively, are significantly correlated in the sense that objects with strong Lyα emission also tend to be older, lower in star formation rate, and less dusty than objects with weak Lyα emission, or the line in absorption. We accordingly conclude that, within the LBG sample, objects with strong Lyα emission represent a later stage of galaxy evolution in which supernovae-induced outflows have reduced the dust covering fraction. We also examined the hypothesis that the attenuation of Lyα photons is lower than that of the continuum, as proposed by some, but found no evidence to support this picture.

  15. Deep Spitzer/IRAC Imaging of the Subaru Deep Field

    NASA Astrophysics Data System (ADS)

    Jiang, Linhua; Egami, Eiichi; Cohen, Seth; Fan, Xiaohui; Ly, Chun; Mechtley, Matthew; Windhorst, Rogier

    2013-10-01

    The last decade saw great progress in our understanding of the distant Universe as a number of objects at z > 6 were discovered. The Subaru Deep Field (SDF) project has played an important role on study of high-z galaxies. The SDF is unique: it covers a large area of 850 sq arcmin; it has extremely deep optical images in a series of broad and narrow bands; it has the largest sample of spectroscopically-confirmed galaxies known at z >= 6, including ~100 Lyman alpha emitters (LAEs) and ~50 Lyman break galaxies (LBGs). Here we propose to carry out deep IRAC imaging observations of the central 75% of the SDF. The proposed observations together with those from our previous Spitzer programs will reach a depth of ~10 hours, and enable the first complete census of physical properties and stellar populations of spectroscopically-confirmed galaxies at the end of cosmic reionization. IRAC data is the key to measure stellar masses and constrain stellar populations in high-z galaxies. From SED modeling with secure redshifts, we will characterize the physical properties of these galaxies, and trace their mass assembly and star formation history. In particular, it allows us, for the first time, to study stellar populations in a large sample of z >=6 LAEs. We will also address some critical questions, such as whether LAEs and LBGs represent physically different galaxy populations. All these will help us to understand the earliest galaxy formation and evolution, and better constrain the galaxy contribution to reionization. The IRAC data will also cover 10,000 emission-line selected galaxies at z < 1.5, 50,000 UV and mass selected LBGs at 1.5 < z < 3, and more than 5,000 LBGs at 3 < z < 6. It will have a legacy value for SDF-related programs.

  16. Discovery of Massive, Mostly Star Formation Quenched Galaxies with Extremely Large Lyα Equivalent Widths at z ˜ 3

    NASA Astrophysics Data System (ADS)

    Taniguchi, Yoshiaki; Kajisawa, Masaru; Kobayashi, Masakazu A. R.; Nagao, Tohru; Shioya, Yasuhiro; Scoville, Nick Z.; Sanders, David B.; Capak, Peter L.; Koekemoer, Anton M.; Toft, Sune; McCracken, Henry J.; Le Fèvre, Olivier; Tasca, Lidia; Sheth, Kartik; Renzini, Alvio; Lilly, Simon; Carollo, Marcella; Kovač, Katarina; Ilbert, Olivier; Schinnerer, Eva; Fu, Hai; Tresse, Laurence; Griffiths, Richard E.; Civano, Francesca

    2015-08-01

    We report a discovery of six massive galaxies with both extremely large Lyα equivalent widths (EWs) and evolved stellar populations at z ˜ 3. These MAssive Extremely STrong Lyα emitting Objects (MAESTLOs) have been discovered in our large-volume systematic survey for strong Lyα emitters (LAEs) with 12 optical intermediate-band data taken with Subaru/Suprime-Cam in the COSMOS field. Based on the spectral energy distribution fitting analysis for these LAEs, it is found that these MAESTLOs have (1) large rest-frame EWs of EW0 (Lyα) ˜ 100-300 Å, (2) M⋆ ˜ 1010.5-1011.1 M⊙, and (3) relatively low specific star formation rates of SFR/M⋆ ˜ 0.03-1 Gyr-1. Three of the six MAESTLOs have extended Lyα emission with a radius of several kiloparsecs, although they show very compact morphology in the HST/ACS images, which correspond to the rest-frame UV continuum. Since the MAESTLOs do not show any evidence for active galactic nuclei, the observed extended Lyα emission is likely to be caused by a star formation process including the superwind activity. We suggest that this new class of LAEs, MAESTLOs, provides a missing link from star-forming to passively evolving galaxies at the peak era of the cosmic star formation history. Based on observations with NASA/ESA Hubble Space Telescope, obtained at the Space Telescope Science Institute, which is operated by AURA, Inc., under NASA contract NAS 5-26555; also based on data collected at the Subaru Telescope, which is operated by the National Astronomical Observatory of Japan; and also based on data products from observations made with ESO Telescopes at the La Silla Paranal Observatory under ESO programme ID 179.A-2005 and on data products produced by TERAPIX and the Cambridge Astronomy Survey Unit on behalf of the UltraVISTA consortium.

  17. High Prevalence of Echocardiographic Abnormalities among HIV-infected Persons in the Era of Highly Active Antiretroviral Therapy.

    PubMed

    Mondy, Kristin E; Gottdiener, John; Overton, E Turner; Henry, Keith; Bush, Tim; Conley, Lois; Hammer, John; Carpenter, Charles C; Kojic, Erna; Patel, Pragna; Brooks, John T

    2011-02-01

    in the era of highly active antiretroviral therapy (HAART), human immunodeficiency virus (HIV)-infected persons have higher cardiovascular disease risk. Little is known about asymptomatic abnormalities in cardiac structure and function in this population. the Study to Understand the Natural History of HIV/AIDS in the Era of Effective Therapy (SUN Study) is a prospective, observational, multi-site cohort of 656 HIV-infected participants who underwent baseline echocardiography during 2004-2006. We examined prevalence of and factors associated with left ventricular systolic dysfunction (LVSD), diastolic dysfunction (DD), pulmonary hypertension (PHTN), left ventricular hypertrophy (LVH), and left atrial enlargement (LAE). participant characteristics were as follows: median age, 41 years; 24% women; 29% non-Hispanic black; 73% receiving HAART; and median CD4+ cell count, 462 cells/μL. Among evaluable participants, 18% had LVSD, 26% had DD, 57% had PHTN (right ventricular pressure >30 mm Hg), 6.5% had LVH, and 40% had LAE. In multivariate analyses, significant factors (P < .05) associated with LVSD were history of MI, elevated highly sensitive C-reactive protein (hsCRP) level, and current tobacco smoking; for DD, elevated hsCRP level and hypertension; for PHTN, current use of ritonavir; for LVH, hypertension, diabetes, non-white race, female sex with elevated body mass index, calculated as the weight in kilograms divided by the square of height in meters, of ≥ 25, elevated hsCRP level, and current use of abacavir; for LAE, hypertension and recent marijuana use. in this large contemporary HIV cohort, the prevalence of subclinical functional and structural cardiac abnormalities was greater than expected for age. Abnormalities were mostly associated with expected and often modifiable risks. Lifestyle modification should become a greater priority in the management of chronic HIV disease.

  18. SUBSTRUCTURE WITHIN THE SSA22 PROTOCLUSTER AT z ≈ 3.09

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Topping, Michael W.; Shapley, Alice E.; Steidel, Charles C., E-mail: mtopping@astro.ucla.edu

    We present the results of a densely sampled spectroscopic survey of the SSA22 protocluster at z ≈ 3.09. Our sample with Keck/LRIS spectroscopy includes 106 Ly α emitters (LAEs) and 40 Lyman break galaxies (LBGs) at z = 3.05–3.12. These galaxies are contained within the 9′ × 9′ region in which the protocluster was discovered, which also hosts the maximum galaxy overdensity in the SSA22 region. The redshift histogram of our spectroscopic sample reveals two distinct peaks, at z = 3.069 (blue; 43 galaxies) and z = 3.095 (red; 103 galaxies). Furthermore, objects in the blue and red peaks aremore » segregated on the sky, with galaxies in the blue peak concentrating toward the western half of the field. These results suggest that the blue and red redshift peaks represent two distinct structures in physical space. Although the double-peaked redshift histogram is traced in the same manner by LBGs and LAEs, and brighter and fainter galaxies, we find that 9 out of 10 X-ray AGNs in SSA22, and all 7 spectroscopically confirmed giant Ly α “blobs,” reside in the red peak. We combine our data set with sparsely sampled spectroscopy from the literature over a significantly wider area, finding preliminary evidence that the double-peaked structure in redshift space extends beyond the region of our dense spectroscopic sampling. In order to fully characterize the three-dimensional structure, dynamics, and evolution of large-scale structure in the SSA22 overdensity, we require the measurement of large samples of LAE and LBG redshifts over a significantly wider area, as well as detailed comparisons with cosmological simulations of massive cluster formation.« less

  19. LINKING Lyα AND LOW-IONIZATION TRANSITIONS AT LOW OPTICAL DEPTH

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Jaskot, A. E.; Oey, M. S.

    2014-08-20

    We suggest that low optical depth in the Lyman continuum (LyC) may relate the Lyα emission, C II and Si II absorption, and C II* and Si II* emission seen in high-redshift galaxies. We base this analysis on Hubble Space Telescope Cosmic Origins Spectrograph spectra of four Green Pea (GP) galaxies, which may be analogs of z > 2 Lyα emitters (LAEs). In the two GPs with the strongest Lyα emission, the Lyα line profiles show reduced signs of resonant scattering. Instead, the Lyα profiles resemble the Hα line profiles of evolved star ejecta, suggesting that the Lyα emission originatesmore » from a low column density and similar outflow geometry. The weak C II absorption and presence of non-resonant C II* emission in these GPs support this interpretation and imply a low LyC optical depth along the line of sight. In two additional GPs, weak Lyα emission and strong C II absorption suggest a higher optical depth. These two GPs differ in their Lyα profile shapes and C II* emission strengths, however, indicating different inclinations of the outflows to our line of sight. With these four GPs as examples, we explain the observed trends linking Lyα, C II, and C II* in stacked LAE spectra, in the context of optical depth and geometric effects. Specifically, in some galaxies with strong Lyα emission, a low LyC optical depth may allow Lyα to escape with reduced scattering. Furthermore, C II absorption, C II* emission, and Lyα profile shape can reveal the optical depth, constrain the orientation of neutral outflows in LAEs, and identify candidate LyC emitters.« less

  20. "All Students Are Brilliant": A Confession of Injustice and a Call to Action

    ERIC Educational Resources Information Center

    Robertson, Amy D.; Elliott, Leslie J. Atkins

    2017-01-01

    The two of us (AR and LAE), in our teaching, research, and work with teachers, advocate for responsive teaching--an approach that seeks out and builds on the productive "seeds of science" in what our students say and do and assumes that "all students…are brilliant." This pedagogical approach requires a commitment to listening…

  1. Influence of fat addition on the antimicrobial activity of sodium lactate, lauric arginate and methylparaben in minced meat.

    PubMed

    Magrinyà, Núria; Terjung, Nino; Loeffler, Myriam; Gibis, Monika; Bou, Ricard; Weiss, Jochen

    2015-12-23

    A minced meat model system containing three different fat levels (0, 15, and 50 wt.%) was used to evaluate the antimicrobial efficacy of three antimicrobials with different aqueous solubilities (sodium lactate>lauric arginate (Nα-lauroyl-L-arginine ethyl ester, LAE)>methylparaben). Various concentrations of sodium lactate (20, 40, and 60 mg/g), lauric arginate (0.5, 1, 1.5, 2.0, and 2.5 mg/g) and methylparaben (0.1, 0.5, 1.0, and 2.0 mg/g) were used to evaluate the antimicrobial activity against natural meat microbiota (total aerobic mesophilic colony counts, coliform bacteria, and lactic acid bacteria). The results indicate that the three antimicrobials tested are influenced at different strengths by the changes of the fat addition of the minced meat. The antimicrobial efficacy of LAE and methylparaben is increased by a higher fat content in the meat batter, whereas for lactate no clear lactate proportionality relationship can be seen. This structure sensitivity is most strongly pronounced with lauric arginate, which we attributed to the amphiphilic character of the molecule. Copyright © 2015 Elsevier B.V. All rights reserved.

  2. Environment of Submillimeter Galaxies

    NASA Astrophysics Data System (ADS)

    Hou, K.-c.; Chen, L.-w.

    2013-10-01

    To study the environment of high-redshift star-forming galaxies — submillimeter galaxies (SMGs) — and their role during large-scale structure formation, we have estimated the galaxy number density fluctuations around SMGs, and analyzed their cross correlation functions with Lyman alpha emitters (LAEs), and optical-selected galaxies with photometric redshift in the COSMOS and ECDFS fields. Only a marginal cross-correlation between SMGs and optical-selected galaxies at most redshifts intervals is found in our results, except a relatively strong correlation detected in the cases of AzTEC-detected SMGs with galaxies at z ˜2.6 and 3.6. The density fluctuations around SMGs with redshift estimated show most SMGs located in a high-density region. There is no correlation signal between LAEs and SMGs, and the galaxy density fluctuations indicate a slightly anti-correlation on a scale smaller than 2 Mpc. Furthermore, we also investigate the density fluctuations of passive and starforming galaxies selected by optical and near infrared colors at similar redshift around SMGs. Finally the implication from our results to the interconnection between high-redshift galaxy populations is discussed.

  3. High Anger Expression is Associated with Reduced Cortisol Awakening Response and Health Complaints in Healthy Young Adults.

    PubMed

    Romero-Martínez, Ángel; Moya-Albiol, Luis

    2016-04-29

    The extant evidence suggests a robust positive association between expression (anger expression-out) and suppression (anger expression-in) of anger and compromised health. Nevertheless, the underlying psychobiological mechanisms which explain these relationships are not well understood. This study examined whether anger expression would predict general health, cortisol awakening response (CAR) and evening cortisol levels in a community sample of 156 healthy young adults of both genders. Participants were distributed into two groups according to their anger expression scores: high and low anger expression (HAE and LAE, respectively). Findings indicated that those with HAE had worse self-reported health (p = .02) and higher CAR than the LAE group (p = .04). Moreover, high levels of anger expression-out (p < .01) and -in (p < .01, for all) predicted a worse self-reported health in both groups. On the other hand, high anger expression-out was associated with flattened CAR but only in the HAE group (p < .01). This study reinforces the need to develop effective strategies to provide mechanisms to regulate anger expression by promoting personal growth and positive skills that enhance individuals' well-being and quality of life and, in turn, their own health.

  4. Manipulating interactions between functional colloidal particles and polyethylene surfaces using interfacial engineering.

    PubMed

    Ziani, Khalid; Barish, Jeffrey A; McClements, David Julian; Goddard, Julie M

    2011-08-01

    The purpose of this study was to examine the interaction between lipid droplets and polyethylene surfaces, representative of those commonly used in food packaging. Lipid droplets with various surface charges were prepared by homogenizing corn oil and water in the presence of surfactants with different electrical characteristics: non-ionic (Tween 80, T80), cationic (lauric arginate, LAE), and/or anionic (sodium dodecyl sulfate, SDS). The ionic properties of polyethylene surfaces were modified by UV-treatment. Stable emulsions containing small droplets (d<200 nm) with nearly neutral (T80), cationic (T80: LAE), and anionic (T80: SDS) charges were prepared by adding different levels of the ionic surfactants to Tween 80 stabilized emulsions. Scanning electronic microscopy (SEM), confocal fluorescence microscopy, and ATR-FTIR showed that the number of droplets attached to the polyethylene surfaces depended on the droplet charge and the polyethylene surface characteristics. The greatest degree of droplet adsorption was observed for the cationic droplets to the UV-ozone treated polyethylene surfaces, which was attributed to electrostatic attraction. These results are important for understanding the behavior of encapsulated lipophilic components in food containers. Copyright © 2011 Elsevier Inc. All rights reserved.

  5. Using site-selection model to identify suitable sites for seagrass transplantation in the west coast of South Sulawesi

    NASA Astrophysics Data System (ADS)

    Lanuru, Mahatma; Mashoreng, S.; Amri, K.

    2018-03-01

    The success of seagrass transplantation is very much depending on the site selection and suitable transplantation methods. The main objective of this study is to develop and use a site-selection model to identify the suitability of sites for seagrass (Enhalus acoroides) transplantation. Model development was based on the physical and biological characteristics of the transplantation site. The site-selection process is divided into 3 phases: Phase I identifies potential seagrass habitat using available knowledge, removes unnecessary sites before the transplantation test is performed. Phase II involves field assessment and transplantation test of the best scoring areas identified in Phase I. Phase III is the final calculation of the TSI (Transplant Suitability Index), based on results from Phases I and II. The model was used to identify the suitability of sites for seagrass transplantation in the West coast of South Sulawesi (3 sites at Labakkang Coast, 3 sites at Awerange Bay, and 3 sites at Lale-Lae Island). Of the 9 sites, two sites were predicted by the site-selection model to be the most suitable sites for seagrass transplantation: Site II at Labakkang Coast and Site III at Lale-Lae Island.

  6. Efficacy of ε-polylysine, lauric arginate, or acidic calcium sulfate applied sequentially for Salmonella reduction on membrane filters and chicken carcasses.

    PubMed

    Benli, Hakan; Sanchez-Plata, Marcos X; Keeton, Jimmy T

    2011-05-01

    Salmonella contamination continues to be one of the major concerns for the microbiological safety of raw poultry products. Application of more than one decontamination agent as a multihurdle intervention to carcasses in a processing line might produce greater reductions than one treatment alone due to different modes of action of individual antimicrobials. In this study, all possible two-way combinations and individual applications of ε-polylysine (EPL), lauric arginate (LAE), and acidic calcium sulfate (ACS) solutions were evaluated for their effects against Salmonella enterica serovars, including Enteritidis and Typhimurium, using a sterile membrane filter model system. The combinations that provided higher Salmonella reductions were further evaluated on inoculated chicken carcasses in various concentrations applied in a sequential manner. Sequential spray applications of 300 mg of EPL per liter followed by 30% ACS and of 200 mg of LAE per liter followed by 30% ACS produced the highest Salmonella reductions on inoculated chicken carcasses, by 2.1 and 2.2 log CFU/ml, respectively. Our results indicated that these sequential spray applications of decontamination agents are effective for decreasing Salmonella contamination on poultry carcasses, but further studies are needed to determine the effectiveness of these combinations over a storage period.

  7. SEURAT: SPH scheme extended with ultraviolet line radiative transfer

    NASA Astrophysics Data System (ADS)

    Abe, Makito; Suzuki, Hiroyuki; Hasegawa, Kenji; Semelin, Benoit; Yajima, Hidenobu; Umemura, Masayuki

    2018-05-01

    We present a novel Lyman alpha (Ly α) radiative transfer code, SEURAT (SPH scheme Extended with Ultraviolet line RAdiative Transfer), where line scatterings are solved adaptively with the resolution of the smoothed particle hydrodynamics (SPH). The radiative transfer method implemented in SEURAT is based on a Monte Carlo algorithm in which the scattering and absorption by dust are also incorporated. We perform standard test calculations to verify the validity of the code; (i) emergent spectra from a static uniform sphere, (ii) emergent spectra from an expanding uniform sphere, and (iii) escape fraction from a dusty slab. Thereby, we demonstrate that our code solves the {Ly} α radiative transfer with sufficient accuracy. We emphasize that SEURAT can treat the transfer of {Ly} α photons even in highly complex systems that have significantly inhomogeneous density fields. The high adaptivity of SEURAT is desirable to solve the propagation of {Ly} α photons in the interstellar medium of young star-forming galaxies like {Ly} α emitters (LAEs). Thus, SEURAT provides a powerful tool to model the emergent spectra of {Ly} α emission, which can be compared to the observations of LAEs.

  8. Perturbing the Hypothalamic Pituitary Adrenal Axis:A Mathematical Model for Interpreting PTSDAssessment Tests

    DTIC Science & Technology

    2017-08-15

    RESEARCH Perturbing the Hypothalamic–Pituitary–Adrenal Axis: A Mathematical Model for Interpreting PTSD Assessment Tests Lae Un Kim1, Maria R...D’Orsogna2, and Tom Chou1 1Department of Biomathematics, University of California, Los Angeles, USA 2Department of Mathematics , California State University...observed features and experimental responses can arise from a bistable mathematical model containing two steady-states, rather than relying on specific

  9. The Relationship between Stellar Populations and Lyα Emission in Lyman Break Galaxies

    NASA Astrophysics Data System (ADS)

    Kornei, Katherine A.; Shapley, Alice E.; Erb, Dawn K.; Steidel, Charles C.; Reddy, Naveen A.; Pettini, Max; Bogosavljević, Milan

    2010-03-01

    We present the results of a photometric and spectroscopic survey of 321 Lyman break galaxies (LBGs) at z~ 3 to investigate systematically the relationship between Lyα emission and stellar populations. Lyα equivalent widths (W Lyα) were calculated from rest-frame UV spectroscopy and optical/near-infrared/Spitzer photometry was used in population synthesis modeling to derive the key properties of age, dust extinction, star formation rate (SFR), and stellar mass. We directly compare the stellar populations of LBGs with and without strong Lyα emission, where we designate the former group (W Lyα>= 20 Å) as Lyα emitters (LAEs) and the latter group (W Lyα< 20 Å) as non-LAEs. This controlled method of comparing objects from the same UV luminosity distribution represents an improvement over previous studies in which the stellar populations of LBGs and narrowband-selected LAEs were contrasted, where the latter were often intrinsically fainter in broadband filters by an order of magnitude simply due to different selection criteria. Using a variety of statistical tests, we find that Lyα equivalent width and age, SFR, and dust extinction, respectively, are significantly correlated in the sense that objects with strong Lyα emission also tend to be older, lower in SFR, and less dusty than objects with weak Lyα emission, or the line in absorption. We accordingly conclude that, within the LBG sample, objects with strong Lyα emission represent a later stage of galaxy evolution in which supernovae-induced outflows have reduced the dust covering fraction. We also examined the hypothesis that the attenuation of Lyα photons is lower than that of the continuum, as proposed by some, but found no evidence to support this picture. Based, in part, on data obtained at the W.M. Keck Observatory, which is operated as a scientific partnership among the California Institute of Technology, the University of California, and NASA, and was made possible by the generous financial support

  10. Mapping the Lyα Emission around a z ˜ 6.6 QSO with MUSE: Extended Emission and a Companion at a Close Separation

    NASA Astrophysics Data System (ADS)

    Farina, Emanuele P.; Venemans, Bram P.; Decarli, Roberto; Hennawi, Joseph F.; Walter, Fabian; Bañados, Eduardo; Mazzucchelli, Chiara; Cantalupo, Sebastiano; Arrigoni-Battaia, Fabrizio; McGreer, Ian D.

    2017-10-01

    We utilize the Multi Unit Spectroscopic Explorer (MUSE) on the Very Large Telescope to search for extended Lyα emission around the z ˜ 6.6 QSO J0305-3150. After carefully subtracting the point spread function, we reach a nominal 5σ surface-brightness limit of SB5σ = 1.9 × 10-18 erg s-1 cm-2 arcsec-2 over a 1 arcsec2 aperture, collapsing five wavelength slices centered at the expected location of the redshifted Lyα emission (I.e., at 9256 Å). Current data suggest the presence (5σ accounting for systematics) of a Lyα nebula that extends for 9 kpc around the QSO. This emission is displaced and redshifted by 155 km s-1 with respect to the location of the QSO host galaxy traced by the [{{C}} {{II}}] 158 μm emission line. The total luminosity is L({Ly}α ) = (3.0 ± 0.4) × 1042 erg s-1. Our analysis suggests that this emission is unlikely to rise from optically thick clouds illuminated by the ionizing radiation of the QSO. It is more plausible that the Lyα emission is due to the fluorescence of the highly ionized optically thin gas. This scenario implies a high hydrogen volume density of {n}{{H}}˜ 6 cm-3. In addition, we detect a Lyα emitter (LAE) in the immediate vicinity of the QSO, I.e., with a projected separation of ˜12.5 kpc and a line-of-sight velocity difference of 560 km s-1. The luminosity of the LAE is L({Ly}α ) = (2.1 ± 0.2) × 1042 erg s-1 and its inferred star-formation rate is SFR ˜ 1.3 M ⊙ yr-1. The probability of finding such a close LAE is one order of magnitude above the expectations based on the QSO-galaxy cross-correlation function. This discovery is in agreement with a scenario where dissipative interactions favor the rapid build-up of supermassive black holes at early cosmic times.

  11. Amphibian Engineers in the Southwest Pacific

    DTIC Science & Technology

    2017-03-08

    groups supporting Marine ground combat on small island chains. Such actions dominate the central Pacific. The ideal depiction of combat is Marine...to: first capture Tulagi and Guadalcanal in the Solomon Islands, second capture the remainder of the Solomon Islands plus Lae and Salamaua, and...air, sea, and ground operations from New Guinea through the Solomons and into the Marianas. Seizing Rabaul was critical to the allied forces in the

  12. Arctic Ice Studies

    DTIC Science & Technology

    1993-02-01

    Aeronautics and Space Administration; DMSP: Defense Meteorological Satellit= innovative helicopter survey for ambient Program; AVHRR: Advanced Very High...a" aA z’•Lae Na g 419" .aso ." -I Nas"o Te a ’ b 0 York A4CJ ’ crk A19. YCrk t•nrtid 0 .436 b = -. 49cr9k Trott *._-. 3 - -. Now A19. No~v, AtC. Nowv

  13. Allergens/Antigens, toxins and polyketides of important Aspergillus species.

    PubMed

    Bhetariya, Preetida J; Madan, Taruna; Basir, Seemi Farhat; Varma, Anupam; Usha, Sarma P

    2011-04-01

    The medical, agricultural and biotechnological importance of the primitive eukaryotic microorganisms, the Fungi was recognized way back in 1920. Among various groups of fungi, the Aspergillus species are studied in great detail using advances in genomics and proteomics to unravel biological and molecular mechanisms in these fungi. Aspergillus fumigatus, Aspergillus flavus, Aspergillus niger, Aspergillus parasiticus, Aspergillus nidulans and Aspergillus terreus are some of the important species relevant to human, agricultural and biotechnological applications. The potential of Aspergillus species to produce highly diversified complex biomolecules such as multifunctional proteins (allergens, antigens, enzymes) and polyketides is fascinating and demands greater insight into the understanding of these fungal species for application to human health. Recently a regulator gene for secondary metabolites, LaeA has been identified. Gene mining based on LaeA has facilitated new metabolites with antimicrobial activity such as emericellamides and antitumor activity such as terrequinone A from A. nidulans. Immunoproteomic approach was reported for identification of few novel allergens for A. fumigatus. In this context, the review is focused on recent developments in allergens, antigens, structural and functional diversity of the polyketide synthases that produce polyketides of pharmaceutical and biological importance. Possible antifungal drug targets for development of effective antifungal drugs and new strategies for development of molecular diagnostics are considered.

  14. Calibrating Late Cretaceous Terrestrial Cyclostratigraphy with High-precision U-Pb Zircon Geochronology: Qingshankou Formation of the Songliao Basin, China

    NASA Astrophysics Data System (ADS)

    Wang, T.; Ramezani, J.; Wang, C.

    2015-12-01

    A continuous succession of Late Cretaceous lacustrine strata has been recovered from the SK-I south (SK-Is) and SKI north (SK-In) boreholes in the long-lived Cretaceous Songliao Basin in Northeast China. Establishing a high-resolution chronostratigraphic framework is a prerequisite for integrating the Songliao record with the global marine Cretaceous. We present high-precision U-Pb zircon geochronology by the chemical abrasion isotope dilution thermal-ionization mass spectrometry method from multiple bentonite core samples from the Late Cretaceous Qingshankou Formation in order to assess the astrochronological model for the Songliao Basin cyclostratigraphy. Our results from the SK-Is core present major improvements in precision and accuracy over the previously published geochronology and allow a cycle-level calibration of the cyclostratigraphy. The resulting choronostratigraphy suggest a good first-order agreement between the radioisotope geochronology and the established astrochronological time scale over the corresponding interval. The dated bentonite beds near the 1780 m depth straddle a prominent oil shale layer of the Qingshankou Formation, which records a basin-wide lake anoxic event (LAE1), providing a direct age constraint for the LAE1. The latter appears to coincide in time with the Late Cretaceous (Turonian) global sea level change event Tu4 presently constrained at 91.8 Ma.

  15. [Prevalence of target organ damage and factors associated with cardiovascular events in subjects with refractory hypertension].

    PubMed

    Armario, Pedro; Oliveras, Anna; Hernández Del Rey, Raquel; Poch, Esteban; Larrouse, María; Roca-Cusachs, Alex; de la Sierra, Alejandro

    2009-06-27

    To asses the prevalence of target organ damage (TOD) and factors associated with cardiovascular events in subjects with refractory hypertension. Cross-sectional study of 146 patients with clinical diagnosis of refractory hypertension. TOD was defined as the presence of microalbuminuria (MA), renal failure (RF), left ventricular hypertrophy (LVH) or left atrial enlargement (LAE). Cardiovascular events were defined as the antecedent of stroke, coronary heart disease, heart failure or peripheral arterial disease. 24-h ambulatory blood pressure monitoring was (ABPM) performed with a validated Spacelabs 90207. The prevalence of LVH was 62.3%, and LAE was observed in 27.7% of the subjects. The prevalence of RF was 28.1% and MA was found in 41,4%. An association between MA and LVH was observed. After adjusting by age, the urinary albumin excretion (UAE) correlated with clinical blood pressure (BP) and BP during 24-h ABPM, whereas LVMI correlated with ambulatory BP but not with clinical BP. The prevalence of previous cardiovascular events was 22% and in the multivariate regression analysis, UAE was the only independent factor associated with the antecedent of cardiovascular events. In subjects with refractory hypertension, the prevalence of TOD was high, and an association between heart and renal organ damage was observed. UAE was independently associated with the antecedent of cardiovascular disease.

  16. Comprehensive Comparison between Empty Nest and Non-Empty Nest Elderly: A Cross-Sectional Study among Rural Populations in Northeast China.

    PubMed

    Chang, Ye; Guo, Xiaofan; Guo, Liang; Li, Zhao; Yang, Hongmei; Yu, Shasha; Sun, Guozhe; Sun, Yingxian

    2016-08-27

    This study aimed to comprehensively compare the general characteristics, lifestyles, serum parameters, ultrasonic cardiogram (UCG) parameters, depression, quality of life, and various comorbidities between empty nest and non-empty nest elderly among rural populations in northeast China. This analysis was based on our previous study which was conducted from January 2012 to August 2013, using a multistage, stratified, random cluster sampling scheme. The final analyzed sample consisted of 3208 participants aged no less than 60 years, which was further classified into three groups: non-empty nest group, empty nest group (living as a couple), and empty nest group (living alone). More than half of the participants were empty nest elderly (60.5%). There were no significant statistical differences for serum parameters, UCG parameters, lifestyles, dietary pattern, and scores of Patient Health Questionnaire-9 (PHQ-9) and World Health Organization Quality of Life questionnaire, abbreviated version (WHOQOL-BREF) among the three groups. Empty nest elderly showed no more risk for comorbidities such as general obesity, abdominal obesity, hyperuricemia, hyperhomocysteinemia, diabetes, dyslipidemia, left atrial enlargement (LAE), and stroke. Our study indicated that empty nest elderly showed no more risk for depression, low quality of life and comorbidities such as general obesity, abdominal obesity, hyperuricemia, hyperhomocysteinemia, diabetes, dyslipidemia, LAE, and stroke among rural populations in northeast China.

  17. The relative importance of noise and vibration from railways.

    PubMed

    Howarth, H V; Griffin, M J

    1990-06-01

    An experiment was conducted to determine the subjective equivalence of railway noise and railway-induced building vibration, and hence the relative importance of the two stimuli. Six magnitudes of whole-body, vertical (z-axis) vibration and six levels of noise were presented simultaneously to each of 30 subjects in all 36 possible paired combinations. The stimuli were reproductions of the noise and vibration recorded inside a house during the passage of a train. The subjects were asked to indicate, after each presentation, which of the two stimuli (noise and vibration) they would prefer to be reduced. A seven-point scale was employed to indicate the total annoyance produced by the two stimuli. A subjective equivalence contour was determined from the levels at which 50% of the subjects preferred the reduction of noise and 50% preferred the reduction of vibration. The contour may be described by the relation L(AE) = 29.3 log10 VDV + 89.2, where L(AE) is the sound exposure level and VDV is the vibration dose value. This relation may be used to determine whether a reduction of noise or a reduction of vibration would be more beneficial to residents near railways. The total annoyance due to simultaneous noise and vibration was shown to depend on the magnitude of both stimuli.

  18. Llamas: Large-area microphone arrays and sensing systems

    NASA Astrophysics Data System (ADS)

    Sanz-Robinson, Josue

    Large-area electronics (LAE) provides a platform to build sensing systems, based on distributing large numbers of densely spaced sensors over a physically-expansive space. Due to their flexible, "wallpaper-like" form factor, these systems can be seamlessly deployed in everyday spaces. They go beyond just supplying sensor readings, but rather they aim to transform the wealth of data from these sensors into actionable inferences about our physical environment. This requires vertically integrated systems that span the entirety of the signal processing chain, including transducers and devices, circuits, and signal processing algorithms. To this end we develop hybrid LAE / CMOS systems, which exploit the complementary strengths of LAE, enabling spatially distributed sensors, and CMOS ICs, providing computational capacity for signal processing. To explore the development of hybrid sensing systems, based on vertical integration across the signal processing chain, we focus on two main drivers: (1) thin-film diodes, and (2) microphone arrays for blind source separation: 1) Thin-film diodes are a key building block for many applications, such as RFID tags or power transfer over non-contact inductive links, which require rectifiers for AC-to-DC conversion. We developed hybrid amorphous / nanocrystalline silicon diodes, which are fabricated at low temperatures (<200 °C) to be compatible with processing on plastic, and have high current densities (5 A/cm2 at 1 V) and high frequency operation (cutoff frequency of 110 MHz). 2) We designed a system for separating the voices of multiple simultaneous speakers, which can ultimately be fed to a voice-command recognition engine for controlling electronic systems. On a device level, we developed flexible PVDF microphones, which were used to create a large-area microphone array. On a circuit level we developed localized a-Si TFT amplifiers, and a custom CMOS IC, for system control, sensor readout and digitization. On a signal processing

  19. ALMA observation of 158 μm [C II] line and dust continuum of a z = 7 normally star-forming galaxy in the epoch of reionization

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Ota, Kazuaki; Walter, Fabian; Da Cunha, Elisabete

    We present ALMA observations of the [C II] line and far-infrared (FIR) continuum of a normally star-forming galaxy in the reionization epoch, the z = 6.96 Lyα emitter (LAE) IOK-1. Probing to sensitivities of σ{sub line} = 240 μJy beam{sup –1} (40 km s{sup –1} channel) and σ{sub cont} = 21 μJy beam{sup –1}, we found the galaxy undetected in both [C II] and continuum. Comparison of ultraviolet (UV)-FIR spectral energy distribution (SED) of IOK-1, including our ALMA limit, with those of several types of local galaxies (including the effects of the cosmic microwave background, CMB, on the FIR continuum)more » suggests that IOK-1 is similar to local dwarf/irregular galaxies in SED shape rather than highly dusty/obscured galaxies. Moreover, our 3σ FIR continuum limit, corrected for CMB effects, implies intrinsic dust mass M {sub dust} < 6.4 × 10{sup 7} M {sub ☉}, FIR luminosity L {sub FIR} < 3.7 × 10{sup 10} L {sub ☉} (42.5-122.5 μm), total IR luminosity L {sub IR} < 5.7 × 10{sup 10} L {sub ☉} (8-1000 μm), and dust-obscured star formation rate (SFR) < 10 M {sub ☉} yr{sup –1}, if we assume that IOK-1 has a dust temperature and emissivity index typical of local dwarf galaxies. This SFR is 2.4 times lower than one estimated from the UV continuum, suggesting that <29% of the star formation is obscured by dust. Meanwhile, our 3σ [C II] flux limit translates into [C II] luminosity, L {sub [C} {sub II]} < 3.4 × 10{sup 7} L {sub ☉}. Locations of IOK-1 and previously observed LAEs on the L {sub [C} {sub II]} versus SFR and L {sub [C} {sub II]}/L {sub FIR} versus L {sub FIR} diagrams imply that LAEs in the reionization epoch have significantly lower gas and dust enrichment than AGN-powered systems and starbursts at similar/lower redshifts, as well as local star-forming galaxies.« less

  20. Cultural Resources Survey and Monitoring of Joint Task Force Six (JTF-6) Actions in Webb, Zapata, Dimmit, La Salle, Duvall, and Jim Hogg Counties, Texas

    DTIC Science & Technology

    1994-08-01

    vegetation, game, and riverine resources. A recent survey conducted for the proposed Camino Colombia Toll Road resulted in the recording of numerous...Trevino, who was reportedly from old Guerrero (also called Revilla, one of the 12 original Spanish colonies founded by Jose De Escandon in 1749 [(Hume 1972...1985). (Scale 1:1) 19 a b c de Figure 10. Diagnostic projectile points of the Lae Archaic period of South Texas: (a) Ensor (Bell 1960); (b) Frio (Turner

  1. Annual Report Number 3, 1986.

    DTIC Science & Technology

    1986-01-01

    REPORT 1986 as DISTPJUtIoN STATE’Tr A Agpprovod for public reI~laeC D is riL u ti o ’ Uni e L h i DIRECTORATE SJUN 109 OF D MANAGEMENT SCIENCES AFLC/XRS...21 2. Incorporate Aircraft Availability Into D041 . 22 3. Weapon System Phase In/Out And The Aircraft Availability Procurement Model (AAPM...Capabilities .. ......... 43 2. Evaluation Of CONUS Cargo Movement Requirements ........ ................. 4 3. Material Management Manpower Standars . 4.....44 V

  2. Extraction of bromelain from pineapple peels.

    PubMed

    Ketnawa, S; Chaiwut, P; Rawdkuen, S

    2011-08-01

    Large amount of pineapple peels (by-products) is left over after processing and they are a potential source for bromelain extraction. Distilled water (DI), DI containing cysteine and ethylenediaminetetraacetic acid (EDTA) (DI-CE), sodium phosphate buffer pH 7.0 (PB) and PB containing cysteine and EDTA (PB-CE) were used as extractants for bromelain from the pineapple peels. The highest bromelain activity was obtained when it was extracted with PB-CE (867 and 1032 units for Nang Lae and Phu Lae cultv, respectively). The PB could maintain the pH of the extract (pH 5.1-5.7) when compared with others. Under sodium dodecyl sulfate polyacrylamide gel electrophoresis, the extract showed protein bands in the range 24-28 kDa. The protein band with a molecular weight of ∼28 kDa exposed the clear zone on blue background under the casein-substrate gel electrophoresis. The effects of the bromelain extract on the protein patterns of beef, chicken and squid muscles were also determined. Trichloroacetic acid soluble peptide content of all the treated muscles increased when the amount of bromelain extract increased. Decrease in myosin heavy chains and actin was observed in all the muscle types when bromelain extract was used. The best extractant for bromelain from pineapple peels was PB-CE. Moreover, bromelain extract could be used as a muscle food tenderizing agent in food industries.

  3. Comprehensive Comparison between Empty Nest and Non-Empty Nest Elderly: A Cross-Sectional Study among Rural Populations in Northeast China

    PubMed Central

    Chang, Ye; Guo, Xiaofan; Guo, Liang; Li, Zhao; Yang, Hongmei; Yu, Shasha; Sun, Guozhe; Sun, Yingxian

    2016-01-01

    This study aimed to comprehensively compare the general characteristics, lifestyles, serum parameters, ultrasonic cardiogram (UCG) parameters, depression, quality of life, and various comorbidities between empty nest and non-empty nest elderly among rural populations in northeast China. This analysis was based on our previous study which was conducted from January 2012 to August 2013, using a multistage, stratified, random cluster sampling scheme. The final analyzed sample consisted of 3208 participants aged no less than 60 years, which was further classified into three groups: non-empty nest group, empty nest group (living as a couple), and empty nest group (living alone). More than half of the participants were empty nest elderly (60.5%). There were no significant statistical differences for serum parameters, UCG parameters, lifestyles, dietary pattern, and scores of Patient Health Questionnaire-9 (PHQ-9) and World Health Organization Quality of Life questionnaire, abbreviated version (WHOQOL-BREF) among the three groups. Empty nest elderly showed no more risk for comorbidities such as general obesity, abdominal obesity, hyperuricemia, hyperhomocysteinemia, diabetes, dyslipidemia, left atrial enlargement (LAE), and stroke. Our study indicated that empty nest elderly showed no more risk for depression, low quality of life and comorbidities such as general obesity, abdominal obesity, hyperuricemia, hyperhomocysteinemia, diabetes, dyslipidemia, LAE, and stroke among rural populations in northeast China. PMID:27618905

  4. Optical Data Processing for Missile Guidance.

    DTIC Science & Technology

    1984-11-21

    and architectures for back -substitution and the solution of triangular systems of LAEs (linear algebraic equations). Most recently, a parallel QR...Calculation of I1 is quite difficult since the o T exact Z matrix is quite ill-conditioned. The two VC choices considered in our system are E - I and E I - 0...shown in fig. 1. It These operations are most commonly referred to as shows the ship in water with a sky and shoreline back - segmentation and also

  5. Final Report on A. R. A. P.’s Model for the Atmospheric Marine Environment

    DTIC Science & Technology

    1982-01-01

    Around Airports," NASA CR-2752, prepared by A.R.A.P. for Marshall Space Center. 25. Brost , R.A. and Wyngaard, N.C., 1978: "A Model Study of the...FRANCE DR. R. A. BROST NCAR P.O. BOX 3000 BOULDER, CO 80307 JOHNS HOPKINS UNIV. APPLIED PHYSICS LAB R.E. GIBSON LIBRARY JOHNS HOPKINS ROAD...RESEARCH LABS BOULDER, CO 80303 DR. GEORGE L. HELLOR GEOPHYSICAL FLUID DYNAMICS LAE PRINCETON, NJ 08540 DR. TETSUJI YAMADA LOS ALAMOS NATIONAL LAB

  6. THE BOSS EMISSION-LINE LENS SURVEY. IV. SMOOTH LENS MODELS FOR THE BELLS GALLERY SAMPLE

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Shu, Yiping; Bolton, Adam S.; Montero-Dorta, Antonio D.

    We present Hubble Space Telescope F606W-band imaging observations of 21 galaxy-Ly α emitter lens candidates in the Baryon Oscillation Spectroscopic Survey Emission-Line Lens Survey (BELLS) for the GALaxy-Ly α EmitteR sYstems (BELLS GALLERY) survey. Seventeen systems are confirmed to be definite lenses with unambiguous evidence of multiple imaging. The lenses are primarily massive early-type galaxies (ETGs) at redshifts of approximately 0.55, while the lensed sources are Ly α emitters (LAEs) at redshifts from two to three. Although most of the lens systems are well fit by smooth lens models consisting of singular isothermal ellipsoids in an external shear field, a thoroughmore » exploration of dark substructures in the lens galaxies is required. The Einstein radii of the BELLS GALLERY lenses are, on average, 60% larger than those of the BELLS lenses because of the much higher source redshifts. This will allow for a detailed investigation of the radius evolution of the mass profile in ETGs. With the aid of the average ∼13× lensing magnification, the LAEs are frequently resolved into individual star-forming knots with a wide range of properties. They have characteristic sizes from less than 100 pc to several kiloparsecs, rest-frame far-UV apparent AB magnitudes from 29.6 to 24.2, and typical projected separations of 500 pc to 2 kpc.« less

  7. Feasibility of remote real-time guidance of a cardiac examination performed by novices using a pocket-sized ultrasound device.

    PubMed

    Mai, Tuan V; Ahn, David T; Phillips, Colin T; Agan, Donna L; Kimura, Bruce J

    2013-01-01

    Background. The potential of pocket-sized ultrasound devices (PUDs) to improve global healthcare delivery is limited by the lack of a suitable imaging protocol and trained users. Therefore, we investigated the feasibility of performing a brief, evidence-based cardiac limited ultrasound exam (CLUE) through wireless guidance of novice users. Methods. Three trainees applied PUDs on 27 subjects while directed by an off-site cardiologist to obtain a CLUE to screen for LV systolic dysfunction (LVSD), LA enlargement (LAE), ultrasound lung comets (ULC+), and elevated CVP (eCVP). Real-time remote audiovisual guidance and interpretation by the cardiologist were performed using the iPhone 4/iPod (FaceTime, Apple, Inc.) attached to the PUD and transmitted data wirelessly. Accuracy and technical quality of transmitted images were compared to on-site, gold-standard echo thresholds. Results. Novice versus sonographer imaging yielded technically adequate views in 122/135 (90%) versus 130/135 (96%) (P < 0.05). CLUE's combined SN, SP, and ACC were 0.67, 0.96, and 0.90. Technical adequacy (%) and accuracy for each abnormality (n) were LVSD (85%, 0.93, n = 5), LAE (89%, 0.74, n = 16), ULC+ (100%, 0.94, n = 5), and eCVP (78%, 0.91, n = 1). Conclusion. A novice can perform the CLUE using PUD when wirelessly guided by an expert. This method could facilitate PUD use for off-site bedside medical decision making and triaging of patients.

  8. NO OVERDENSITY OF LYMAN-ALPHA EMITTING GALAXIES AROUND A QUASAR AT z  ∼ 5.7

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Mazzucchelli, C.; Bañados, E.; Decarli, R.

    2017-01-01

    Bright quasars, observed when the universe was less than one billion years old ( z  > 5.5), are known to host massive black holes (∼10{sup 9} M {sub ⊙}) and are thought to reside in the center of massive dark matter overdensities. In this picture, overdensities of galaxies are expected around high-redshift quasars. However, observations based on the detection of Lyman-break galaxies (LBGs) around these quasars do not offer a clear picture: this may be due to the uncertain redshift constraints of LBGs, which are solely selected through broadband filters. To circumvent such uncertainties, we here perform a search for Lyman-alphamore » emitting galaxies (LAEs) in the field of the quasar PSO J215.1512–16.0417 at z  ∼ 5.73, through narrowband deep imaging with FORS2 at the Very Large Telescope. We study an area of 37 arcmin{sup 2}, i.e., ∼206 comoving Mpc{sup 2} at the redshift of the quasar. We find no evidence of an overdensity of LAEs in the quasar field with respect to blank-field studies. Possible explanations for these findings may be that our survey volume is too small, or that the strong ionizing radiation from the quasar hinders galaxy formation in its immediate proximity. Another possibility is that these quasars are not situated in the dense environments predicted by some simulations.« less

  9. Collision propagation in Papua New Guinea and Solomon Sea

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Silver, E.A.; Abbott, L.; Kirchoff-Stein, K.

    The collision of the Finisterre-New Britain terrane with the Australian continent is propagating eastward at a rate of approximately 125 km/m.y., based on plate motions and the collisional geometry, as well as on the geochemistry of the arc volcanics. A sequence of sedimentary facies is developed from east to west in the modern environment (pelagic sediments, turbidites, marine molasse, and fluvial molasse), and this sequence is accreted from north to south at the front of the terrane collision in the Markham valley. Based on the modern distribution, the authors suggest that the age of the initial marine molasse will predatemore » the passage of the collision point, and that of the fluvial molasse will postdate its passage. Intense erosion in the Markham canyon, located along the suture between the collision point and the coast, appears to be responsible for stripping most of the accreted marine molasse and redepositing it in a basin just east of the collision point. Convergence along the suture zone deceases westward. At Lae, very young deformation is seen, but 80 km to the west undeformed terrace deposits cover the deformation front. Uplift appears active within the range, aided by out-of-sequence thrusting, but still farther west the rocks lack signs of young tectonism. In the region just west of Lae, the main locus of slip between the Australian and south Bismarck plates must transfer southward to the front of the Papuan fold-and-thrust belt.« less

  10. Corrosion behavior, biocompatibility and biomechanical stability of a prototype magnesium-based biodegradable intramedullary nailing system.

    PubMed

    Krämer, Manuel; Schilling, Markus; Eifler, Rainer; Hering, Britta; Reifenrath, Janin; Besdo, Silke; Windhagen, Henning; Willbold, Elmar; Weizbauer, Andreas

    2016-02-01

    Implants made of degradable magnesium alloys are a potential alternative to conventional orthopaedic implant materials, e.g. stainless steel or titanium. Intramedullary nails made of the magnesium alloy LAE442 were subjected to cyclic fatigue tests in both distilled water and Hank's Balanced Salt Solution (HBSS) at 37.5°C until implant failure or a limit of 500,000cycles was reached. In distilled water, four of the five nails were still intact after the end of the biomechanical test. In HBSS, a breakage within the first 70,000 bending cycles was observed. Additionally, the degradation rate of this alloy was determined in HBSS according to the weight loss method (0.24±0.12mmyear(-1)) and based on gas release (0.21±0.03mmyear(-1)) with a standard eudiometer. A cytotoxicity test with L929 cells was carried out in accordance with EN ISO 10993-5/12. This test demonstrated sufficient cell viability of the diluted extracts (50%, 25% and 12.5%). The relative metabolic activity of the 100% extract was reduced slightly below 70%, which is classified as a threshold value for cytotoxicity. In conclusion, this in vitro study indicates that intramedullary nails made of LAE442 may not have the required fatigue resistance for load-bearing applications and the development of a corrosion-protective coating may be necessary to prevent early failure of the implant. Copyright © 2015 Elsevier B.V. All rights reserved.

  11. Diagnostic Utility of High Sensitivity Troponins for Echocardiographic Markers of Structural Heart Disease.

    PubMed

    Wang, Tom Kai Ming; Dugo, Clementina; Gillian, Yvonne; Yvonne, Wynne; Heather, Semple; Kevin, Smith; Peter, Cleave; Jonathan, Christiansen; Andrew, To; Nezar, Amir; Scott, Tony; Ross, Boswell; Patrick, Gladding

    2018-02-15

    The conventional use of high-sensitivity troponins (hs-troponins) is for diagnosing myocardial infarction however they also have a role in chronic disease management. This pilot study assessed the relationship of hs-troponins with echocardiographic markers of left ventricular hypertrophy (LVH) and structural heart disease (SHD). Patients undergoing computer gomography (CT) coronary angiogram for low-intermediate risk chest pain and healthy volunteers were recruited. Hs-troponins Singulex I, Abbott I and Roche T and N-terminal pro-brain natriuretic peptide (NT-proBNP) were evaluated in relation to SHD parameters including left ventricular hypertrophy (LVH Echo ) and left atrial enlargement (LAE Echo ) on echocardiography. 78 subjects who underwent echocardiography were included in this study. C-statistics (95% confidence interval) of the four biomarkers for predicting LVH Echo were 0.84 (0.72-0.92), 0.84 (0.73-0.92), 0.75 (0.63-0.85) and 0.62 (0.49-0.74); for LAE Echo 0.74 (0.6-0.85), 0.78 (0.66-0.88), 0.55 (0.42-0.67) and 0.68 (0.62-0.85); and composite SHD 0.79 (0.66-0.88), 0.87 (0.75-0.94), 0.62 (0.49-0.73) and 0.74 (0.62-0.84) respectively. Optimal cut points for SHD were >1.2 ng/L, >1.6 ng/L, >8 ng/L and >18 pmol/L respectively. These results advocate the potential role of hs-troponins as screening tools for structural heart disease with theranostic implications.

  12. The influence of storage and heat treatment on a magnesium-based implant material: an in vitro and in vivo study.

    PubMed

    Bracht, Katja; Angrisani, Nina; Seitz, Jan-Marten; Eifler, Rainer; Weizbauer, Andreas; Reifenrath, Janin

    2015-10-19

    Magnesium alloys are recommended as a potential material for osteosynthesis. It is known that storage-induced property modifications can occur in materials like aluminum. Thus the aim of this study was to analyze the influence of storage durations of up to 48 weeks on the biomechanical, structural, and degradation properties of the degradable magnesium alloy LAE442. Extruded implants (n = 104; Ø 2.5 mm × 25 mm) were investigated after storage periods of 0, 12, 24, and 48 weeks in three different sub-studies: (I) immediately after the respective storage duration and after an additional (II) 56 days of in vitro corrosion in simulated body fluid (SFB), and (III) 48 weeks in vivo corrosion in a rabbit model, respectively. In addition, the influence of a T5-heat treatment (206 °C for 15 h in an argon atmosphere) was tested (n = 26; 0 week of storage). Evaluation was performed by three-point bending, scanning electron microscopy, radiography, µ-computed tomography, evaluation of the mean grain size, and contrast analysis of precipitations (such as aluminum or lithium). The heat treatment induced a significant reduction in initial stability, and enhanced the corrosion resistance. In vivo experiments showed a good biocompatibility for all implants. During the storage of up to 48 weeks, no significant changes occurred in the implant properties. LAE442 implants can be safely used after up to 48 weeks of storage.

  13. LAE1 regulates expression of multiple secondary metabolite gene clusters in Fusarium verticillioides

    USDA-ARS?s Scientific Manuscript database

    The filamentous fungus Fusarium verticillioides can cause disease of maize and is capable of producing the polyketide derived mycotoxins called fumonisins. Fumonisin contamination of maize kernels is a food safety concern. Fumonisins have been implicated in human esophageal cancer as well as in cau...

  14. National Dam Safety Program. Rock Island Lake Dam (NJ 00819) Wallkill River Basin, Rock Island Lake, Sussex County, New Jersey. Phase I Inspection Report.

    DTIC Science & Technology

    1981-08-01

    8 Y4 Z] 4 .TTL ad util)r.~!E or... 4 wone~fl idwk., p- 4 , r nmburgd I ~~~’~~ Alet~ arytoJ 0- I ~ embers rns d CALEt IN MAILES FDATE: ,JtJ I" I H ey Lae arREGw APPENDIX 1 CHECK LIST...7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 3 IN. SCALE I 3 4 ~ a, 4 l4CjAcL-J C 5 -6 -I--.r r \\ -I ,,) 7 8 lp,:/ __.!o____._.

  15. CECOM Index of Technical Papers, International Wire and Cable Symposia,

    DTIC Science & Technology

    1982-10-18

    ROOS. J.SoL. SEVENT4 SYIPOS1U.Mv 1959 8AD-656295) 143 MEAS’JRF1i4T JF THE DEGIEE OF DISPERSION OF CARBON B3LACK IN POYETHY LENE USING A3 SORPTION OF...COMPOSITIONS (AGING, wAXES) BY: YURGENt W.J. PALINCHAK9 So STICKNEY, P.8. TENTH SYMPOSI’UM, 1961 (AD-656172) 218 WATER Ati SORPTION OF ELASTOMERS BY: BIRIGGS9...Fl %R CA3Lf oESIGN AND MANUFAC -3USCHMER G. 55b WATER VAPOR SORPTION OF POI.YETHYLENE: A DECISI -JSCHER, G. 975 CORRELATION BTWCEN LAeORATJRY TESTS

  16. Chinese-English Rocketry Dictionary. Volume 3

    DTIC Science & Technology

    1979-03-01

    xiezhen diania 14] Q i. plate tank 1’? yangil yanghuara $, anodic oxidation process 18 yangji yinji dianya I3 A.j - I t anode -cathode voltage...talo Gu Yin yin aao ou Ylng Yin ta’u Ou YU You taluan cuan Yuing Yawg talui cul 341 tau tm yuan ruan toa ’Wg Cown Yft ye. tfu tu Yfln t’tian tuant...tanhuang Jiahe mopian 94f X laE f(4 ’m’. #j spring-loaded membrane 14 tanhuang Jiaju A1 A -)t spring clawp 15 tanhuang Jianshendian A1 &c A V -’P spring

  17. A New Population of High-z, Dusty Lyman-alpha Emitters and Blobs Discovered by WISE: Feedback Caught in the Act?

    NASA Technical Reports Server (NTRS)

    Bridge, Carrie R.; Blain, Andrew; Borys, Colin J. K.; Petty, Sara; Benford, Dominic; Eisenhardt, Peter; Farrah, Duncan; Griffith, Roger, L.; Jarrett, Tom; Lonsdale, Carol; hide

    2013-01-01

    By combining data from the NASA Wide-field Infrared Survey Explorer (WISE) mission with optical spectroscopy from the W. M. Keck telescope, we discover a mid-IR color criterion that yields a 78% success rate in identifying rare, typically radio-quiet, 1.6 approx. < z approx. < 4.6 dusty Ly-alpha emitters (LAEs). Of these, at least 37% have emission extended on scales of 30-100 kpc and are considered Ly-alpha "blobs" (LABs). The objects have a surface density of only approx.. 0.1 deg(exp -2), making them rare enough that they have been largely missed in deep, small area surveys. We measured spectroscopic redshifts for 92 of these galaxies, and find that the LAEs (LABs) have a median redshift of 2.3 (2.5). The WISE photometry coupled with data from Herschel (Herschel is an ESA space observatory with science instruments provided by European-led Principal Investigator consortia and with important participation from NASA) reveals that these galaxies are in the Hyper Luminous IR galaxy regime (L(sub IR) approx. > 10(exp 13)-10(exp 14) Solar L) and have warm colors. They are typically more luminous and warmer than other dusty, z approx.. 2 populations such as submillimeter-selected galaxies and dust-obscured galaxies. These traits are commonly associated with the dust being illuminated by intense active galactic nucleus activity. We hypothesize that the combination of spatially extended Ly-alpha, large amounts of warm IR-luminous dust, and rarity (implying a short-lived phase) can be explained if the galaxies are undergoing brief, intense "feedback" transforming them from an extreme dusty starburst/QSO into a mature galaxy.

  18. Association of fungal secondary metabolism and sclerotial biology

    PubMed Central

    Calvo, Ana M.; Cary, Jeffrey W.

    2015-01-01

    Fungal secondary metabolism and morphological development have been shown to be intimately associated at the genetic level. Much of the literature has focused on the co-regulation of secondary metabolite production (e.g., sterigmatocystin and aflatoxin in Aspergillus nidulans and Aspergillus flavus, respectively) with conidiation or formation of sexual fruiting bodies. However, many of these genetic links also control sclerotial production. Sclerotia are resistant structures produced by a number of fungal genera. They also represent the principal source of primary inoculum for some phytopathogenic fungi. In nature, higher plants often concentrate secondary metabolites in reproductive structures as a means of defense against herbivores and insects. By analogy, fungi also sequester a number of secondary metabolites in sclerotia that act as a chemical defense system against fungivorous predators. These include antiinsectant compounds such as tetramic acids, indole diterpenoids, pyridones, and diketopiperazines. This chapter will focus on the molecular mechanisms governing production of secondary metabolites and the role they play in sclerotial development and fungal ecology, with particular emphasis on Aspergillus species. The global regulatory proteins VeA and LaeA, components of the velvet nuclear protein complex, serve as virulence factors and control both development and secondary metabolite production in many Aspergillus species. We will discuss a number of VeA- and LaeA-regulated secondary metabolic gene clusters in A. flavus that are postulated to be involved in sclerotial morphogenesis and chemical defense. The presence of multiple regulatory factors that control secondary metabolism and sclerotial formation suggests that fungi have evolved these complex regulatory mechanisms as a means to rapidly adapt chemical responses to protect sclerotia from predators, competitors and other environmental stressors. PMID:25762985

  19. Tomographic reconstruction of storm time RC ion distribution from ENA images on board multiple spacecraft

    NASA Astrophysics Data System (ADS)

    Ma, Shu-Ying; Yan, Wei-Nan; Xu, Liang

    2015-11-01

    A quantitative retrieval of 3-D distribution of energetic ions as energetic neutral atoms (ENA) sources is a challenging task. In this paper the voxel computerized tomography (CT) method is initially applied to reconstruct the 3-D distribution of energetic ions in the magnetospheric ring current (RC) region from ENA emission images on board multiple spacecraft. To weaken the influence of low-altitude emission (LAE) on the reconstruction, the LAE-associated ENA intensities are corrected by invoking the thick-target approximation. To overcome the divergence in iteration due to discordant instrument biases, a differential ENA voxel CT method is developed. The method is proved reliable and advantageous by numerical simulation for the case of constant bias independent of viewing angle. Then this method is implemented with ENA data measured by the Two Wide-angle Imaging Neutral-atom Spectrometers mission which performs stereoscopic ENA imaging. The 3-D spatial distributions and energy spectra of RC ion flux intensity are reconstructed for energies of 4-50 keV during the main phase of a major magnetic storm. The retrieved ion flux distributions seem to correspond to an asymmetric partial RC, located mainly around midnight favoring the postmidnight with L = 3.5-7.0 in the equatorial plane. The RC ion distributions with magnetic local time depend on energy, with major equatorial flux peak for lower energy located east of that for higher energy. In comparison with the ion energy spectra measured by Time History of Events and Macroscale Interactions during Substorms-D satellite flying in the RC region, the retrieved spectrum from remotely sensed ENA images are well matched with the in situ measurements.

  20. Empirical Characterization of Low-Altitude Ion Flux Derived from TWINS

    NASA Astrophysics Data System (ADS)

    Goldstein, J.; LLera, K.; McComas, D. J.; Redfern, J.; Valek, P. W.

    2018-05-01

    In this study we analyze ion differential flux from 10 events between 2008 and 2015. The ion fluxes are derived from low-altitude emissions (LAEs) in energetic neutral atom (ENA) images obtained by Two Wide-angle Imaging Neutral-atom Spectrometers (TWINS). The data set comprises 119.44 hr of observations, including 4,284 per energy images with 128,277 values of differential ENA flux from pixels near Earth's limb. Limb pixel data are extracted and mapped to a common polar ionospheric grid and associated with values of the Dst index. Statistical analysis is restricted to pixels within 10% of the LAE emissivity peak. For weak Dst conditions we find a premidnight peak in the average ion precipitation, whose flux and location are relatively insensitive to energy. For moderate Dst, elevated flux levels appear over a wider magnetic local time (MLT) range, with a separation of peak locations by energy. Strong disturbances bring a dramatic flux increase across the entire nightside at all energies but strongest for low energies in the postmidnight sector. The arrival of low-energy ions can lower the average energy for strong Dst, even as it raises the total integral number flux. TWINS-derived ion fluxes provide a macroscale measurement of the average precipitating ion distribution and confirm that convection, either quasi-steady or bursty, is an important process controlling the spatial and spectral properties of precipitating ions. The premidnight peak (weak Dst), MLT widening and energy-versus-MLT dependence (moderate Dst), and postmidnight low-energy ion enhancement (strong Dst) are consistent with observations and models of steady or bursty convective transport.

  1. Health Services for Gender-Based Violence: Médecins Sans Frontières Experience Caring for Survivors in Urban Papua New Guinea.

    PubMed

    Lokuge, Kamalini; Verputten, Meggy; Ajakali, Maryanne; Tolboom, Bianca; Joshy, Grace; Thurber, Katherine A; Plana, Daisy; Howes, Steven; Wakon, Anastasia; Banks, Emily

    2016-01-01

    Levels of gender-based violence in Papua New Guinea (PNG) are high; health services for survivors are limited. Evidence from the few existing health services for survivors can inform improvements in care in this and similar settings. Médecins Sans Frontières supported health services for survivors in Lae, PNG from 2008-2013. Routine monitoring data from August 2010-April 2013 were used to describe patient and service characteristics. 5,892 individuals received care over 6,860 presentations, the majority self-referred or referred by friends and family. Presentations were attributed to intimate partner violence(62%), non-partner sexual violence(15%), other forms of violence(3%), and past (but not current) violence(21%). 97% were female; an estimated 4.9% (95%CI:4.8-5.0%) of females resident in the catchment area presented to the programme during the 2.8years analysed. Of presentations for non-partner sexual violence, 79% knew their abuser and 50% were children <16 years. 92% of presentations reporting current violence received medical treatment for injuries. The majority of patients who received multiple counselling sessions reported improved functioning and decreased severity of psycho-social complaints. Community awareness of the availability of free, best-practice, accessible, confidential medical and counselling services for sexual and gender-based violence in Lae, PNG resulted in many survivors presenting for care. High levels of ongoing intimate partner violence and child sexual abuse by known abusers indicates that alongside comprehensive medical care, access to effective services in non-health sectors such as policing, protection and legal services are needed if survivors are to escape the cycle of violence.

  2. Symposium on Underwater Physiology (7th), July 5-10, 1980, Athens, Greece

    DTIC Science & Technology

    1980-07-10

    bean dirtttenpiui-iridi tinsta lae a ti-li-too11 andittin, Isisiatr ,ardn rhc da at"I"iah a~iriys` I a it- " thac iec torneaaa Witsh "Apoptit...Mljettil t iulywaaI’Vided Ifntoi tfoout of f ifteen *utiait]f’ eapkio0Atd ill 11 ilylfie- I 61010 1 ilmrfItted Withi nbisovatitub florts I deoloh...ll I nhllel II.I cc I e IIc-III II I e llce cl h ll i’iiiic II ’ 111. I nhIe eIi; i-ci le in e ccli.,-lll 11 lcec qiiieee-. iec ,e’l ll~ Icicle hlte l

  3. Dealing with Taxes. Tierra de Oportunidad Module 17. LAES: Latino Adult Education Services Project.

    ERIC Educational Resources Information Center

    Kissam, Ed; Dorsey, Holda

    This module, which may be used as the basis for a workshop or as a special topic unit in adult basic education or English-as-a-Second-Language (ESL) courses, addresses how to file and pay federal income taxes. Topics covered include the following: defining tax-related vocabulary; analyzing tax credits and selecting the most appropriate ones;…

  4. VizieR Online Data Catalog: LAE candidates around bright Lyα blobs (Badescu+, 2017)

    NASA Astrophysics Data System (ADS)

    Badescu, T.; Yang, Y.; Bertoldi, F.; Zabludoff, A.; Karim, A.; Magnelli, B.

    2018-04-01

    We obtain narrowband images covering a total area of ~1°x0.5° around the two known Lyα blobs (Yang+ 2009ApJ...693.1579Y) using the Mosaic1.1 camera on the Kitt Peak National Observatory (KPNO) Mayall 4m telescope. In Figure 1 we show the areas covered by the National Optical Astronomical Observatory (NOAO) Deep Wide-field Survey (NDWFS) and the locations of our two pointings (hereafter Bootes1 and Bootes2) centered on 14:31:42.22,+35:31:19.9 and 14:28:54.08,+35:31:19.9. Observations were carried out on 2011 April 29 and 30, with exposure times of 7.3 and 6.0hr, respectively. The filter has a central wavelength of λc=4030Å and a bandwidth of ΔλFWHM=47Å, corresponding to the Lyα emission at z=2.3. Apart from the narrowband (NB) images, we also use NDWFS broadband BW-, R-, and I-band images for continuum estimation. (2 data files).

  5. DIFFUSE Ly{alpha} EMITTING HALOS: A GENERIC PROPERTY OF HIGH-REDSHIFT STAR-FORMING GALAXIES

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Steidel, Charles C.; Bogosavljevic, Milan; Shapley, Alice E.

    2011-08-01

    Using a sample of 92 UV continuum-selected, spectroscopically identified galaxies with (z) = 2.65, all of which have been imaged in the Ly{alpha} line with extremely deep narrow-band imaging, we examine galaxy Ly{alpha} emission profiles to very faint surface brightness limits. The galaxy sample is representative of spectroscopic samples of Lyman break galaxies (LBGs) at similar redshifts in terms of apparent magnitude, UV luminosity, inferred extinction, and star formation rate and was assembled without regard to Ly{alpha} emission properties. Approximately 45% (55%) of the galaxy spectra have Ly{alpha} appearing in net absorption (emission), with {approx_equal} 20% satisfying commonly used criteriamore » for the identification of 'Ly{alpha} emitters' (LAEs; W{sub 0}(Ly{alpha}) {>=} 20 A). We use extremely deep stacks of rest-UV continuum and continuum-subtracted Ly{alpha} images to show that all sub-samples exhibit diffuse Ly{alpha} emission to radii of at least 10'' ({approx}80 physical kpc). The characteristic exponential scale lengths for Ly{alpha} line emission exceed that of the {lambda}{sub 0} = 1220 A UV continuum light by factors of {approx}5-10. The surface brightness profiles of Ly{alpha} emission are strongly suppressed relative to the UV continuum light in the inner few kpc, by amounts that are tightly correlated with the galaxies' observed spectral morphology; however, all galaxy sub-subsamples, including that of galaxies for which Ly{alpha} appears in net absorption in the spectra, exhibit qualitatively similar diffuse Ly{alpha} emission halos. Accounting for the extended Ly{alpha} emission halos, which generally would not be detected in the slit spectra of individual objects or with typical narrow-band Ly{alpha} imaging, increases the total Ly{alpha} flux (and rest equivalent width W{sub 0}(Ly{alpha})) by an average factor of {approx}5, and by a much larger factor for the 80% of LBGs not classified as LAEs. We argue that most, if not all, of the

  6. Imaging of diffuse H I absorption structure in the SSA22 protocluster region at z = 3.1

    NASA Astrophysics Data System (ADS)

    Mawatari, Ken; Inoue, Akio K.; Yamada, Toru; Hayashino, Tomoki; Otsuka, Takuya; Matsuda, Yuichi; Umehata, Hideki; Ouchi, Masami; Mukae, Shiro

    2017-06-01

    Using galaxies as background light sources to map intervening Ly α absorption is a novel approach to study the interplay among galaxies, the circumgalactic medium (CGM) and the intergalactic medium. Introducing a new measure of z = 3.1 H I Ly α absorption relative to the cosmic mean, ΔNB497, estimated from photometric data of star-forming galaxies at 3.3 ≲ z ≲ 3.5, we have made two-dimensional ΔNB497 maps in the z = 3.1 SSA22 protocluster region and two control fields (Subaru/XMM-Newton Deep Survey; Great Observatory Optical Deep Survey North) with a spatial resolution of ˜5 comoving Mpc. The ΔNB497 measurements in the SSA22 field are systematically larger than those in the control fields, and this H I absorption enhancement extends more than 50 comoving Mpc. The field-averaged (I.e. ˜50 comoving Mpc scale) ΔNB497 and the overdensity of Ly α emitters (LAEs) seem to be correlated, while there is no clear dependency of the ΔNB497 on the local LAE overdensity in a few comoving Mpc scale. These results suggest that diffuse H I gas spreads out in/around the SSA22 protocluster. We have also found an enhancement of ΔNB497 at a projected distance <100 physical kpc from the nearest z = 3.1 galaxies at least in the SSA22 field, which is probably due to H I gas associated with the CGM of individual galaxies. The H I absorption enhancement in the CGM-scale tends to be weaker around galaxies with stronger Ly α emission, which suggests that the Ly α escape fraction from galaxies depends on hydrogen neutrality in the CGM.

  7. Atrial Cardiopathy and Cryptogenic Stroke: A Cross-sectional Pilot Study.

    PubMed

    Yaghi, Shadi; Boehme, Amelia K; Hazan, Rebecca; Hod, Eldad A; Canaan, Alberto; Andrews, Howard F; Kamel, Hooman; Marshall, Randolph S; Elkind, Mitchell S V

    2016-01-01

    There is increasing evidence that left atrial dysfunction or cardiopathy is associated with ischemic stroke risk independently of atrial fibrillation. We aimed to determine the prevalence of atrial cardiopathy biomarkers in patients with cryptogenic stroke. We included consecutive patients with ischemic stroke enrolled in the New York Columbia Collaborative Specialized Program of Translational Research in Acute Stroke registry between December 1, 2008, and April 30, 2012. Medical records were reviewed and patients with a diagnosis of cryptogenic stroke were identified. Atrial cardiopathy was defined as at least one of the following: serum N-terminal probrain natriuretic peptide (NT-proBNP) level greater than 250 pg/mL, P-wave terminal force velocity in lead V1 (PTFV1) on electrocardiogram (ECG) greater than 5000 µV⋅ms, or severe left atrial enlargement (LAE) on echocardiogram. We compared clinical, echocardiographic, and radiological characteristics between patients with and without atrial cardiopathy. Among 40 patients with cryptogenic stroke, 63% had at least one of the biomarkers of atrial cardiopathy; 49% had elevated NT-proBNP levels, 20% had evidence of increased PTFV1 on ECG, and 5% had severe LAE. Patients with atrial cardiopathy were more likely to be older (76 versus 62 years, P = .012); have hypertension (96% versus 33%, P < .001), hyperlipidemia (60% versus 27%, P = .05), or coronary heart disease (28% versus 0%, P = .033); and less likely to have a patent foramen ovale (4% versus 40%, P = .007). There is a high prevalence of biomarkers indicative of atrial cardiopathy in patients with cryptogenic stroke. Clinical trials are needed to determine whether these patients may benefit from anticoagulation to prevent stroke. Copyright © 2015 National Stroke Association. Published by Elsevier Inc. All rights reserved.

  8. Extreme Faint Flux Imaging with an EMCCD

    NASA Astrophysics Data System (ADS)

    Daigle, Olivier; Carignan, Claude; Gach, Jean-Luc; Guillaume, Christian; Lessard, Simon; Fortin, Charles-Anthony; Blais-Ouellette, Sébastien

    2009-08-01

    An EMCCD camera, designed from the ground up for extreme faint flux imaging, is presented. CCCP, the CCD Controller for Counting Photons, has been integrated with a CCD97 EMCCD from e2v technologies into a scientific camera at the Laboratoire d’Astrophysique Expérimentale (LAE), Université de Montréal. This new camera achieves subelectron readout noise and very low clock-induced charge (CIC) levels, which are mandatory for extreme faint flux imaging. It has been characterized in laboratory and used on the Observatoire du Mont Mégantic 1.6 m telescope. The performance of the camera is discussed and experimental data with the first scientific data are presented.

  9. Subaru studies of the cosmic dawn

    PubMed Central

    IYE, Masanori

    2011-01-01

    An overview on the current status of the census of the early Universe population is given. Observational surveys of high redshift objects provide direct opportunities to study the early epoch of the Universe. The target population included are Lyman Alpha Emitters (LAE), Lyman Break Galaxies (LBG), gravitationally lensed galaxies, quasars and gamma-ray bursts (GRB). The basic properties of these objects and the methods used to study them are reviewed. The present paper highlights the fact that the Subaru Telescope group made significant contributions in this field of science to elucidate the epoch of the cosmic dawn and to improve the understanding of how and when infant galaxies evolve into mature ones. PMID:22075759

  10. Type of vegetable oils used in cooking and risk of metabolic syndrome among Asian Indians.

    PubMed

    Lakshmipriya, Nagarajan; Gayathri, Rajagopal; Praseena, Kallingal; Vijayalakshmi, Parthasarathy; Geetha, Gunasekaran; Sudha, Vasudevan; Krishnaswamy, Kamala; Anjana, Ranjit Mohan; Henry, Jeyakumar; Mohan, Viswanathan

    2013-03-01

    There is little data on the type of vegetable oil used and the prevalence of metabolic syndrome (MS) in Asian Indians. Food frequency questionnaire was used to document the type of cooking oil in 1875 adults in Chennai city. MS was assessed by new harmonizing criteria. The prevalence of MS was higher among sunflower oil users (30.7%) than palmolein (23.2%) and traditional oil (17.1%, p < 0.001) users. The higher prevalence of MS in sunflower oil group persisted even when stratified according to body mass index, except in obese groups. The risk of MS was further compounded by quantity of refined cereals consumed. Higher LA%E and linoleic acid/alpha-linolenic acid ratio in sunflower oil probably contributes to increased risk of MS.

  11. 20. 'Erection Plan, Renewal of Bridge 210 C over Sacramento ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    20. 'Erection Plan, Renewal of Bridge 210 C over Sacramento River near Tehama, Calif., 3 140'-0' S. T. Riveted Thru Truss Spans, 17'-9' C. to C. Trusses, 31'-0' C. To C. Chords. U.S.S. P. Co. Pacific Coast Dept., Order No. SF 604, Southern Pacific Co., Order No. 51168-P-38428, 1925 Specifications, Scale in. ft., American Bridge Co., Ambridge Plant, Dwgs. made at Ambridge No. 5 in charge of Reehl, Detailed by W.F.R., Date, Checked by L.A.E., Date 1/5/29, Fld. conn. chk. by ENN, Date 3/9/29, Order No. F5659, Sheet No. E3.' - Southern Pacific Railroad Shasta Route, Bridge No. 210.52, Milepost 210.52, Tehama, Tehama County, CA

  12. Development and validation of an LC-MS/MS method to quantify lysergic acid diethylamide (LSD), iso-LSD, 2-oxo-3-hydroxy-LSD, and nor-LSD and identify novel metabolites in plasma samples in a controlled clinical trial.

    PubMed

    Dolder, Patrick C; Liechti, Matthias E; Rentsch, Katharina M

    2018-02-01

    Lysergic acid diethylamide (LSD) is a widely used recreational drug. The aim of this study was to develop and validate a liquid chromatography tandem mass spectrometry (LC-MS/MS) method for the quantification of LSD, iso-LSD, 2-oxo-3-hydroxy LSD (O-H-LSD), and nor-LSD in plasma samples from 24 healthy subjects after controlled administration of 100 μg LSD in a clinical trial. In addition, metabolites that have been recently described in in vitro studies, including lysergic acid monoethylamide (LAE), lysergic acid ethyl-2-hydroxyethylamide (LEO), 2-oxo-LSD, trioxylated-LSD, and 13/14-hydroxy-LSD, should be identified. Separation of LSD and its metabolites was achieved on a reversed phase chromatography column after turbulent-flow online extraction. For the identification and quantification, a triple-stage quadrupole LC-MS/MS instrument was used. The validation data showed slight matrix effects for LSD, iso-LSD, O-H-LSD, or nor-LSD. Mean intraday and interday accuracy and precision were 105%/4.81% and 105%/4.35% for LSD, 98.7%/5.75% and 99.4%/7.21% for iso-LSD, 106%/4.54% and 99.4%/7.21% for O-H-LSD, and 107%/5.82% and 102%/5.88% for nor-LSD, respectively. The limit of quantification was 0.05 ng/mL for LSD, iso-LSD, and nor-LSD and 0.1 ng/mL for O-H-LSD. The limit of detection was 0.01 ng/mL for all compounds. The method described herein was accurate, precise, and the calibration range within the range of expected plasma concentrations. LSD was quantified in the plasma samples of the 24 subjects of the clinical trial, whereas iso-LSD, O-H-LSD, nor-LSD, LAE, LEO, 13/14-hydroxy-LSD, and 2-oxo-LSD could only sporadically be detected but were too low for quantification. © 2017 Wiley Periodicals, Inc.

  13. Essential Oils Modulate Gene Expression and Ochratoxin A Production in Aspergillus carbonarius.

    PubMed

    El Khoury, Rachelle; Atoui, Ali; Verheecke, Carol; Maroun, Richard; El Khoury, Andre; Mathieu, Florence

    2016-08-19

    Ochratoxin A (OTA) is a mycotoxin, mainly produced on grapes by Aspergillus carbonarius, that causes massive health problems for humans. This study aims to reduce the occurrence of OTA by using the ten following essential oils (E.Os): fennel, cardamom, anise, chamomile, celery, cinnamon, thyme, taramira, oregano and rosemary at 1 µL/mL and 5 µL/mL for each E.O.As a matter of fact, their effects on the OTA production and the growth of A. carbonarius S402 cultures were evaluated, after four days at 28 °C on a Synthetic Grape Medium (SGM). Results showed that A. carbonarius growth was reduced up to 100%, when cultured with the E.Os of cinnamon, taramira, and oregano at both concentrations and the thyme at 5 µL/mL. As for the other six E.Os, their effect on A. carbonarius growth was insignificant, but highly important on the OTA production. Interestingly, the fennel E.O at 5 µL/mL reduced the OTA production up to 88.9% compared to the control, with only 13.8% of fungal growth reduction. We further investigated the effect of these E.Os on the expression levels of the genes responsible for the OTA biosynthesis (acOTApks and acOTAnrps along with the acpks gene) as well as the two regulatory genes laeA and vea, using the quantitative Reverse Transcription-Polymerase Chain Reaction (qRT-PCR) method. The results revealed that these six E.Os reduced the expression of the five studied genes, where the ackps was downregulated by 99.2% (the highest downregulation in this study) with 5 µL/mL of fennel E.O.As for the acOTApks, acOTAnrps, veA and laeA, their reduction levels ranged between 10% and 96% depending on the nature of the E.O and its concentration in the medium.

  14. The Lyα properties of faint galaxies at z ∼ 2-3 with systemic redshifts and velocity dispersions from Keck-MOSFIRE

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Erb, Dawn K.; Steidel, Charles C.; Trainor, Ryan F.

    2014-11-01

    We study the Lyα profiles of 36 spectroscopically detected Lyα-emitters (LAEs) at z ∼ 2-3, using Keck MOSFIRE to measure systemic redshifts and velocity dispersions from rest-frame optical nebular emission lines. The sample has a median optical magnitude R=26.0, and ranges from R≃23 to R>27, corresponding to rest-frame UV absolute magnitudes M {sub UV} ≅ –22 to M {sub UV} > –18.2. Dynamical masses range from M {sub dyn} < 1.3 × 10{sup 8} M {sub ☉} to M {sub dyn} = 6.8 × 10{sup 9} M {sub ☉}, with a median value of M {sub dyn} = 6.3 ×more » 10{sup 8} M {sub ☉}. Thirty of the 36 Lyα emission lines are redshifted with respect to the systemic velocity with at least 1σ significance, and the velocity offset with respect to systemic Δv {sub Lyα} is correlated with the R-band magnitude, M {sub UV}, and the velocity dispersion measured from nebular emission lines with >3σ significance: brighter galaxies with larger velocity dispersions tend to have larger values of Δv {sub Lyα}. We also make use of a comparison sample of 122 UV-color-selected R<25.5 galaxies at z ∼ 2, all with Lyα emission and systemic redshifts measured from nebular emission lines. Using the combined LAE and comparison samples for a total of 158 individual galaxies, we find that Δv {sub Lyα} is anti-correlated with the Lyα equivalent width with 7σ significance. Our results are consistent with a scenario in which the Lyα profile is determined primarily by the properties of the gas near the systemic redshift; in such a scenario, the opacity to Lyα photons in lower mass galaxies may be reduced if large gaseous disks have not yet developed and if the gas is ionized by the harder spectrum of young, low metallicity stars.« less

  15. Antibacterial activities of β-glucan (laminaran) against gram-negative and gram-positive bacteria

    NASA Astrophysics Data System (ADS)

    Chamidah, A.; Hardoko, Prihanto, A. A.

    2017-05-01

    This study aimed to determine the antibacterial activity of β-Glucan (laminaran) of LAE and LME extracts from brown algae Sargassum crassifolium using HPMS and Ultrasonication against Gram-positive bacteria (Bacillus subtilis and Staphylococcus aureus) and Gram-negative bacteria (Salmonella typhimurium and Escherichia coli). The highest antibacterial activities of LME extract obtained using the HPMS method against Gram-positive bacteria (B. subtilis and S. aureus) were at 18:10 and 18.80 mm. The ultrasonication method showed a lower inhibition trend than the HPMS method, with MIC and MBC values of 250 mg/ml and 2-8 CFU/ml, respectively, in all Gram-negative and Gram-positive bacteria. The results showed that LME extract at a concentration of 250 mg/mL is bacteriostatic against Gram-positive and -negative bacteria.

  16. 1984 CRC (Coordinating Research Council) Octane Number Requirement Survey.

    DTIC Science & Technology

    1985-12-01

    Knocking IAE 230A3/LAE 230A3 14 13 5 38.5 (Knock Sensor, Max. [high]) NAR F25A3/HAR F25A3/ IAR F25A3/LAR F25A3 12 11 8 72.7 NAX 228A3/HAX 228A3 13 10 6...102 -- 14 86 91.4 10.6 103 -- 5 95 92.6 10.4 7 C- 3 TABLE C-111 -" - 44. SENSITIVITIES OF 1984 AND 1983 FBRU AND FBRSU FUELS FBRU FBRSJ Research...c CA LA V) - I- 00 co =I CJ 9 Lo a, INN wo. I"L co 0 I- J o󈧄A ON m ~ al c m M. CDj CDa *l 14 00 1 I0 ff Ln tD1 00 ON Q𔃾.036 P-04 -, LOJ L- %% W D m

  17. Neutron Decay Electron Injection into the Magnetosphere.

    DTIC Science & Technology

    1982-03-01

    1000 Seconds After a Fission Burst, AFWL-TR-78-4 (November, 1978). 3. Hess, Wilmot N., The Radiation Belt and Magnetosphere, Toronto: Blaisdell Pub. Co...0a z w :3 1.-- w Ix -j L ccz I-- -i Ui)z L) 0 x La I- z) La La x . 4 I z 0. 1- ua CD cn I- 4 0)-- Cw m LaE Cf . w- La w z- L ZI--V 1- 0 La IM w z 0 x 0...mD (a "- U) :3-4 La 0 -0 M ..jZ z IM Ix Z in zci o Z L M0 2 EnC woo >- I- c La V~)P) Z -0 -0 Z 0 ik: co u x U) 4. w cD-4 lz La >-ix - Cf ) wI- xL (lI I

  18. Galaxy Transformation Under Extreme Conditions: The Evolution of Galaxies in the Largest Structures in the High Redshift Universe

    NASA Astrophysics Data System (ADS)

    Lemaux, Brian Clark

    This dissertation describes research performed in the field of observational astrophysics as part of the Observations of Redshift Evolution in Large Scale Environment (ORELSE) survey. The general motivation of the research presented in this dissertation is to investigate the processes responsible for the evolution of galaxies in a wide range of physical conditions over cosmic time. Throughout this dissertation, galaxy populations will be considered in the very nearby universe (i.e., within one billion light years from Earth), the middle-aged universe (i.e., eight billion years ago), and in the very early universe (i.e., just one billion years after the beginning of the universe). In each chapter I present unique data from observations taken and analyzed specifically for the ORELSE survey. In the first part of this dissertation I describe the context, aims, and current state of the ORELSE survey. The studies presented in this dissertation span a large range of galaxy samples and investigate a variety of different astrophysical phenomena. As all of these studies fall under the context of galaxy evolution, these initial sections will set the framework for the variety of studies presented in this thesis. In the second part of this dissertation I present four studies undertaken to investigate various aspects of galaxy evolution. The first of these studies is an investigation of a large population of very distant galaxies detected in one of the ORELSE fields. The survey in this field represents the deepest survey of a particular kind of very distant galaxy population known as Lymanalpha Emitter (LAEs). The number of LAEs found in this survey far exceeded expectations for such galaxies and are shown to be in excess of every other survey of similar galaxies at similar distances. This result has important consequences for galaxy evolution studies, as it suggests that faint LAEs may be much more numerous than previously thought. This work also has important consequences for

  19. Lagrangian averaging, nonlinear waves, and shock regularization

    NASA Astrophysics Data System (ADS)

    Bhat, Harish S.

    In this thesis, we explore various models for the flow of a compressible fluid as well as model equations for shock formation, one of the main features of compressible fluid flows. We begin by reviewing the variational structure of compressible fluid mechanics. We derive the barotropic compressible Euler equations from a variational principle in both material and spatial frames. Writing the resulting equations of motion requires certain Lie-algebraic calculations that we carry out in detail for expository purposes. Next, we extend the derivation of the Lagrangian averaged Euler (LAE-alpha) equations to the case of barotropic compressible flows. The derivation in this thesis involves averaging over a tube of trajectories etaepsilon centered around a given Lagrangian flow eta. With this tube framework, the LAE-alpha equations are derived by following a simple procedure: start with a given action, expand via Taylor series in terms of small-scale fluid fluctuations xi, truncate, average, and then model those terms that are nonlinear functions of xi. We then analyze a one-dimensional subcase of the general models derived above. We prove the existence of a large family of traveling wave solutions. Computing the dispersion relation for this model, we find it is nonlinear, implying that the equation is dispersive. We carry out numerical experiments that show that the model possesses smooth, bounded solutions that display interesting pattern formation. Finally, we examine a Hamiltonian partial differential equation (PDE) that regularizes the inviscid Burgers equation without the addition of standard viscosity. Here alpha is a small parameter that controls a nonlinear smoothing term that we have added to the inviscid Burgers equation. We show the existence of a large family of traveling front solutions. We analyze the initial-value problem and prove well-posedness for a certain class of initial data. We prove that in the zero-alpha limit, without any standard viscosity

  20. Patterns of failure after radical prostatectomy in prostate cancer - implications for radiation therapy planning after 68Ga-PSMA-PET imaging.

    PubMed

    Schiller, Kilian; Sauter, K; Dewes, S; Eiber, M; Maurer, T; Gschwend, J; Combs, S E; Habl, G

    2017-09-01

    Salvage radiotherapy (SRT) after radical prostatectomy (RPE) and lymphadenectomy (LAE) is the appropriate radiotherapy option for patients with persistent/ recurrent prostate cancer (PC). 68 Ga-PSMA-PET imaging has been shown to accurately detect PC lesions in a primary setting as well as for local recurrence or for lymph node (LN) metastases. In this study we evaluated the patterns of recurrence after RPE in patients with PC, putting a highlight on the differentiation between sites that would have been covered by a standard radiation therapy (RT) field in consensus after the RTOG consensus and others that would have not. Thirty-one out of 83 patients (37%) with high-risk PC were the subject of our study. Information from 68 Ga-PSMA-PET imaging was used to individualize treatment plans to include suspicious lesions as well as possibly boost sites with tracer uptake in LN or the prostate bed. For evaluation, 68 Ga-PSMA-PET-positive LN were contoured in a patient dataset with a standard lymph drainage (RTOG consensus on CTV definition of pelvic lymph nodes) radiation field depicting color-coded nodes that would have been infield or outfield of that standard lymph drainage field and thereby visualizing typical patterns of failure of a "blind" radiation therapy after RPE and LAE. Compared to negative conventional imaging (CT/MRI), lesions suspicious for PC were detected in 27/31 cases (87.1%) by 68 Ga-PSMA-PET imaging, which resulted in changes to the radiation concept. There were 16/31 patients (51.6%) that received a simultaneous integrated boost (SIB) to a subarea of the prostate bed (in only three cases this dose escalation would have been planned without the additional knowledge of 68 Ga-PSMA-PET imaging) and 18/31 (58.1%) to uncommon (namely presacral, paravesical, pararectal, preacetabular and obturatoric) LN sites. Furthermore, 14 patients (45.2%) had a changed TNM staging result by means of 68 Ga-PSMA-PET imaging. Compared to conventional CT or MRI staging, 68

  1. 3D-NTT: a versatile integral field spectro-imager for the NTT

    NASA Astrophysics Data System (ADS)

    Marcelin, M.; Amram, P.; Balard, P.; Balkowski, C.; Boissin, O.; Boulesteix, J.; Carignan, C.; Daigle, O.; de Denus Baillargeon, M.-M.; Epinat, B.; Gach, J.-L.; Hernandez, O.; Rigaud, F.; Vallée, P.

    2008-07-01

    The 3D-NTT is a visible integral field spectro-imager offering two modes. A low resolution mode (R ~ 300 to 6 000) with a large field of view Tunable Filter (17'x17') and a high resolution mode (R ~ 10 000 to 40 000) with a scanning Fabry-Perot (7'x7'). It will be operated as a visitor instrument on the NTT from 2009. Two large programmes will be led: "Characterizing the interstellar medium of nearby galaxies with 2D maps of extinction and abundances" (PI M. Marcelin) and "Gas accretion and radiative feedback in the early universe" (PI J. Bland Hawthorn). Both will be mainly based on the Tunable Filter mode. This instrument is being built as a collaborative effort between LAM (Marseille), GEPI (Paris) and LAE (Montreal). The website adress of the instrument is : http://www.astro.umontreal.ca/3DNTT

  2. Cosmic ray anisotropy along with interplanetary transients

    NASA Astrophysics Data System (ADS)

    Mishra, Rajesh Kumar

    The present work deals with the study of first three harmonics of low amplitude anisotropic wave trains of cosmic ray intensity over the period 1991-1994 for Deep River neutron monitoring station. It is observed that the diurnal time of maximum remains in the corotational direction; whereas, the time of maximum for both diurnal and semi-diurnal anisotropy has significantly shifted towards later hours as compared to the quiet day annual average for majority of the LAE events. It is noticed that these events are not caused either by the high-speed solar wind streams or by the sources on the Sun responsible for producing these streams; such as, polar coronal holes. The direction of the tri-diurnal anisotropy shows a good negative correlation with Bz component of interplanetary magnetic field. The occurrence of low amplitude events is dominant for positive polarity of Bz. The Disturbance Storm Time index i.e. Dst remains consistently negative only throughout the entire low amplitude wave train event.

  3. Crossover fungal pathogens: the biology and pathogenesis of fungi capable of crossing kingdoms to infect plants and humans.

    PubMed

    Gauthier, Gregory M; Keller, Nancy P

    2013-12-01

    The outbreak of fungal meningitis associated with contaminated methylprednisolone acetate has thrust the importance of fungal infections into the public consciousness. The predominant pathogen isolated from clinical specimens, Exserohilum rostratum (teleomorph: Setosphaeria rostrata), is a dematiaceous fungus that infects grasses and rarely humans. This outbreak highlights the potential for fungal pathogens to infect both plants and humans. Most crossover or trans-kingdom pathogens are soil saprophytes and include fungi in Ascomycota and Mucormycotina phyla. To establish infection, crossover fungi must overcome disparate, host-specific barriers, including protective surfaces (e.g. cuticle, skin), elevated temperature, and immune defenses. This review illuminates the underlying mechanisms used by crossover fungi to cause infection in plants and mammals, and highlights critical events that lead to human infection by these pathogens. Several genes including veA, laeA, and hapX are important in regulating biological processes in fungi important for both invasive plant and animal infections. Copyright © 2013 Elsevier Inc. All rights reserved.

  4. A Ly{alpha} GALAXY AT REDSHIFT z = 6.944 IN THE COSMOS FIELD

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Rhoads, James E.; Hibon, Pascale; Malhotra, Sangeeta

    2012-06-20

    Ly{alpha} emitting galaxies can be used to study cosmological reionization, because a neutral intergalactic medium (IGM) scatters Ly{alpha} photons into diffuse halos whose surface brightness falls below typical survey detection limits. Here, we present the Ly{alpha} emitting galaxy LAE J095950.99+021219.1, identified at redshift z = 6.944 in the COSMOS field using narrowband imaging and follow-up spectroscopy with the IMACS instrument on the Magellan I Baade telescope. With a single object spectroscopically confirmed so far, our survey remains consistent with a wide range of IGM neutral fraction at z Almost-Equal-To 7, but further observations are planned and will help clarify themore » situation. Meantime, the object we present here is only the third Ly{alpha}-selected galaxy to be spectroscopically confirmed at z {approx}> 7, and is {approx}2-3 times fainter than the previously confirmed z Almost-Equal-To 7 Ly{alpha} galaxies.« less

  5. Educational and Social Development in Doi Ang Khang: A Comparative Study of the Khob Dong and Nor Lae Villages

    ERIC Educational Resources Information Center

    Frost, Timothy; Gray, Lauren; Lake, John; Roy, Jessica

    2007-01-01

    Northern Thailand is home to many hill tribes, who have lived for hundreds of years as subsistence farmers or nomadic hunters. In the 1940s, communist insurgencies drove many hill tribes from China, Burma, and other nations south into northern Thailand. Uprooted from their native lands, the hill tribes left behind ties to economic resources and,…

  6. On the Analysis of the Printing Nip on Sheetfed Lithographic Presses and its Implications on the Runnability of Common Substrates

    NASA Astrophysics Data System (ADS)

    Diaz, Francisco J.

    This dissertation is based on the thesis that: Adequate analysis of the offset printing nip, under proper solutions of the Navier-Stokes equations---NSE---for the ink flow and, every day common sense, must provide answers to relevant questions still pending response in the offset printing process. Among these questions are: the influence of wall pressure on the flow, the presence or lack thereof of cavitation, the influence of the Newtonian and non- Newtonian conditions of the ink and, the validity of Stefan's law in the flow as ink and substrate split from the blanket/ink interface. As those questions are properly studied and, solutions are provided on the influence of the ink flow on common substrates (mainly focused on coated papers). Answers are presented on ink velocity profiles, influence of ink viscosity and ink layer height (under full ink coverage), and adequate release of the substrate at common SFO---Sheet Fed Offset---printing conditions. In order to understand the flow, a model is proposed by using a thin channel, high aspect ratio, based on the very thin ink layer running at 2 microns (2 x 10--6 m) through a long contacting channel S, of 0.012 m, while the walls move at a set velocity of 3 m/s and known contacting pressure (peaking at the center at 1 MPa). The problem is divided in two regions with similar geometry (high aspect ratio) but, with different boundary conditions. Inside the nip, the problem is a Couette-like flow. Once it leaves the nip, the problem turns into an adhesion matter. Due the high aspect ratio, NSE can be simplified to the Lubrication Approximation Equations---LAE. The printing process is absolutely symmetric in the depth direction of the flow---considered here as y-direction in accordance with paper physics literature---, validating the simplification of the study from 3D to 2D. The physics and geometry of the flow indicate as well that: the fluid is incompressible, the interaction of the ink and substrate happen very rapidly

  7. Regulation of raft-dependent endocytosis

    PubMed Central

    Lajoie, P; Nabi, IR

    2007-01-01

    Abstract Raft-dependent endocytosis is in large part defined as the cholesterol-sensitive, clathrin-independent internalization of ligands and receptors from the plasma membrane. It encompasses the endocytosis of caveo-lae, smooth plasmalemmal vesicles that form a subdomain of cholesterol and sphingolipid-rich lipid rafts and that are enriched for caveolin-1. While sharing common mechanisms, like cholesterol sensitivity, raft endocytic routes show differential regulation by various cellular components including caveolin-1, dynamin-2 and regulators of the actin cytoskeleton. Dynamin-dependent raft pathways, mediated by caveolae and morphologically equivalent non-caveolin vesicular intermediates, are referred to as caveolae/raft-dependent endocytosis. In contrast, dynamin-independent raft pathways are mediated by non-caveolar intermediates. Raft-dependent endocytosis is regulated by tyrosine kinase inhibitors and, through the regulation of the internalization of various ligands, receptors and effectors, is also a determinant of cellular signaling. In this review, we characterize and discuss the regulation of raft-dependent endocytic pathways and the role of key regulators such as caveolin-1. PMID:17760830

  8. Degradation of magnesium and its alloys: dependence on the composition of the synthetic biological media.

    PubMed

    Mueller, Wolf-Dieter; de Mele, Monica Fernández Lorenzo; Nascimento, Maria Lucia; Zeddies, Miriam

    2009-08-01

    Magnesium and its alloys are highly degradable metals that are potentially useful as biomaterials, especially in orthopaedic and cardiovascular applications. However, the in vivo corrosion has proved to be too high. Because of the complexity of in vivo conditions, a careful study of the corrosion of magnesium in synthetic solutions that simulate the in vivo environment is necessary as a first approach to predict the actual in vivo situation. The aim of this work was to evaluate the influence of the electrolyte composition on the corrosion behavior of magnesium and two Mg-alloys in synthetic biological media. Pure magnesium and its alloys (AZ31 and LAE442) were employed in the experiments. Electrochemical potentiodynamic polarization curves were recorded in sodium chloride and PBS electrolytes with different chloride ion and albumin concentration. Optical and SEM observations complemented by EDX analysis were made. The results showed that magnesium corrosion is localized in chloride- and albumin-containing buffer solutions. They also showed that the chloride concentration and the presence of buffer and protein strongly affect the electrochemical behavior of magnesium and magnesium alloys.

  9. Host-pathogen interaction in Fusarium oxysporum infections: where do we stand?

    PubMed

    Husaini, Amjad M; Sakina, Aafreen; Cambay, Souliha R

    2018-03-16

    Fusarium oxysporum, a ubiquitous soil-borne pathogen causes devastating vascular wilt in more than 100 plant species and ranks fifth among top ten fungal plant pathogens. It has emerged as a human pathogen too, causing infections in immune-compromised patients. It is, therefore, important to gain insight into the molecular processes involved in the pathogenesis of this trans-kingdom pathogen. A complex network comprising of interconnected and over lapping signal pathways; mitogen-activated protein kinase (MAPK) signaling pathways, Ras proteins, G-protein signaling components and their downstream pathways, components of the velvet (LaeA/VeA/VelB) complex and cAMP pathways, is involved in perceiving the host. This network regulates the expression of various pathogenicity genes. Plants have however evolved an elaborate protection system to combat this attack. They too possess intricate mechanisms at molecular level, which once triggered by pathogen attack transduce signals to activate defense response. This review focuses on understanding and presenting a wholistic picture of the molecular mechanisms of F. oxysporum-host interactions in plant immunity.

  10. Combinatorial function of velvet and AreA in transcriptional regulation of nitrate utilization and secondary metabolism.

    PubMed

    López-Berges, Manuel S; Schäfer, Katja; Hera, Concepción; Di Pietro, Antonio

    2014-01-01

    Velvet is a conserved protein complex that functions as a regulator of fungal development and secondary metabolism. In the soil-inhabiting pathogen Fusarium oxysporum, velvet governs mycotoxin production and virulence on plant and mammalian hosts. Here we report a previously unrecognized role of the velvet complex in regulation of nitrate metabolism. F. oxysporum mutants lacking VeA or LaeA, two key components of the complex, were impaired in growth on the non-preferred nitrogen sources nitrate and nitrite. Both velvet and the general nitrogen response GATA factor AreA were required for transcriptional activation of nitrate (nit1) and nitrite (nii1) reductase genes under de-repressing conditions, as well as for the nitrate-triggered increase in chromatin accessibility at the nit1 locus. AreA also contributed to chromatin accessibility and expression of two velvet-regulated gene clusters, encoding biosynthesis of the mycotoxin beauvericin and of the siderophore ferricrocin. Thus, velvet and AreA coordinately orchestrate primary and secondary metabolism as well as virulence functions in F. oxysporum. Copyright © 2013 Elsevier Inc. All rights reserved.

  11. The influence of the emulsion composition on the wettability of the emulsion

    NASA Astrophysics Data System (ADS)

    Liu, Yan Jun; Shao, Jian Nan; Lei Liu, Peng

    2018-03-01

    In order to explore the influence of the emulsion composition on the wettability of the emulsion, using lauric acid polyoxyethylene esters (LAE) and polyethylene oleic acid diester (DQA) as the emulsifier and oleic acid ester (QA) as the smoothing agent, the spinning oil emulsion system with the content of smoothing agent above 30% was prepared. The results show that: with the increase of emulsion concentration, the surface tension of emulsion, the contact Angle of emulsion on the surface of the polypropylene fiber and the wetting time of canvas in emulsion all decreases. At the same time,the emulsion has critical micelle concentration, when the concentration is less than CMC, the surface tension of emulsion, the contact Angle of emulsion on the surface of the polypropylene fiber and the wetting time of canvas in the emulsion decreases rapidly with the increase of the emulsion concentration, while it’s more than this concentration, the influence of emulsion concentration on the three kinds of nature is smaller. Besides, the increase of the mass fraction of the smoothing agent and the increase of the compound emulsifier HLB will result in worse wettability.

  12. A robust signal processing method for quantitative high-cycle fatigue crack monitoring using soft elastomeric capacitor sensors

    NASA Astrophysics Data System (ADS)

    Kong, Xiangxiong; Li, Jian; Collins, William; Bennett, Caroline; Laflamme, Simon; Jo, Hongki

    2017-04-01

    A large-area electronics (LAE) strain sensor, termed soft elastomeric capacitor (SEC), has shown great promise in fatigue crack monitoring. The SEC is able to monitor strain changes over a mesoscale structural surface and endure large deformations without being damaged under cracking. Previous tests verified that the SEC is able to detect, localize, and monitor fatigue crack activities under low-cycle fatigue loading. In this paper, to examine the SEC's capability of monitoring high-cycle fatigue cracks, a compact specimen is tested under cyclic tension, designed to ensure realistic crack opening sizes representative of those in real steel bridges. To overcome the difficulty of low signal amplitude and relatively high noise level under high-cycle fatigue loading, a robust signal processing method is proposed to convert the measured capacitance time history from the SEC sensor to power spectral densities (PSD) in the frequency domain, such that signal's peak-to-peak amplitude can be extracted at the dominant loading frequency. A crack damage indicator is proposed as the ratio between the square root of the amplitude of PSD and load range. Results show that the crack damage indicator offers consistent indication of crack growth.

  13. A Three-Way Transcriptomic Interaction Study of a Biocontrol Agent (Clonostachys rosea), a Fungal Pathogen (Helminthosporium solani), and a Potato Host (Solanum tuberosum).

    PubMed

    Lysøe, Erik; Dees, Merete W; Brurberg, May Bente

    2017-08-01

    Helminthosporium solani causes silver scurf, which affects the quality of potato. The biocontrol agent Clonostachys rosea greatly limited the severity of silver scurf symptoms and amount of H. solani genomic DNA in laboratory experiments. Transcriptomic analysis during interaction showed that H. solani gene expression was highly reduced when coinoculated with the biocontrol agent C. rosea, whereas gene expression of C. rosea was clearly boosted as a response to the pathogen. The most notable upregulated C. rosea genes were those encoding proteins involved in cellular response to oxidative stress, proteases, G-protein signaling, and the methyltransferase LaeA. The most notable potato response to both fungi was downregulation of defense-related genes and mitogen-activated protein kinase kinase kinases. At a later stage, this shifted, and most potato defense genes were turned on, especially those involved in terpenoid biosynthesis when H. solani was present. Some biocontrol-activated defense-related genes in potato were upregulated during early interaction with C. rosea alone that were not triggered by H. solani alone. Our results indicate that the reductions of silver scurf using C. rosea are probably due to a combination of mechanisms, including mycoparasitism, biocontrol-activated stimulation of plant defense mechanisms, microbial competition for nutrients, space, and antibiosis.

  14. Green Peas emit X-rays: Extreme Star Formation in Early Universe Analog Galaxies

    NASA Astrophysics Data System (ADS)

    Brorby, Matthew; Kaaret, Philip

    2017-01-01

    Luminous compact galaxies (LCGs), Lyman Alpha Emitters (LAEs), and Lyman Break Analog galaxies (LBAs) are all used as proxies for star-forming galaxies in the early Universe (z ≥ 6). The X-ray emission from such galaxies has been found to be elevated compared to other star-forming galaxies in our local Universe. It has been suggested that this may be due to the lower metallicity seen in these proxies to high-redshift galaxies and the elevated X-ray emission may affect the heating and Reionization evolution of the early Universe. Our previous studies have suggested the existence of an LX-SFR-metallicity plane for all star-forming galaxies. We present these results in the context of our newest Joint Chandra/HST study containing the first X-ray detection of the Green Pea galaxies, a population of compact starburst galaxies discovered by volunteers in the Galaxy Zoo Project (Cardamone+2009). The galaxies were given the name Green Peas due to their compact size and green appearance in the gri composite images from SDSS. The green color is caused by a strong [OIII]λ5007Å emission line, an indicator of recent star formation. We observed a few of the most promising candidates with joint Chandra/HST observation and discuss our findings here.

  15. Effects of antimicrobial coatings and cryogenic freezing on survival and growth of Listeria innocua on frozen ready-to-eat shrimp during thawing.

    PubMed

    Guo, Mingming; Jin, Tony Z; Scullen, O Joseph; Sommers, Christopher H

    2013-08-01

    Foodborne pathogens such as Listeria monocytogenes could pose a health risk on frozen ready-to-eat (RTE) shrimp as the pathogen could grow following thawing. In this study, antimicrobial-coating treatments alone, or in combination with cryogenic freezing, were evaluated for their ability to inhibit the growth of Listeria innocua, a surrogate for L. monocytogenes, on RTE shrimp. Cooked RTE shrimp were inoculated with L. innocua at 3 population levels and treated with coating solutions consisting of chitosan, allyl isothiocyanate (AIT), or lauric arginate ester (LAE). The treated shrimp were then stored at -18 °C for 6 d before being thawed at 4, 10, or 22 °C for either 24 or 48 h. Results revealed that antimicrobial coatings achieved approximately 5.5 to 1 log CFU/g reduction of L. innocua on RTE shrimp after the treatments, depending on the inoculated population levels. The coating-treated shrimp samples had significantly (P < 0.05) less L. innocua than controls at each thawing temperature and time. Cryogenic freezing in combination with coating treatments did not achieve synergistic effects against L. innocua. Antimicrobial coatings can help to improve product safety by reducing Listeria on RTE shrimp. Journal of Food Science © 2013 Institute of Food Technologists® No claim to original US government works.

  16. Distinct innate immune phagocyte responses to Aspergillus fumigatus conidia and hyphae in zebrafish larvae.

    PubMed

    Knox, Benjamin P; Deng, Qing; Rood, Mary; Eickhoff, Jens C; Keller, Nancy P; Huttenlocher, Anna

    2014-10-01

    Aspergillus fumigatus is the most common filamentous fungal pathogen of immunocompromised hosts, resulting in invasive aspergillosis (IA) and high mortality rates. Innate immunity is known to be the predominant host defense against A. fumigatus; however, innate phagocyte responses to A. fumigatus in an intact host and their contributions to host survival remain unclear. Here, we describe a larval zebrafish A. fumigatus infection model amenable to real-time imaging of host-fungal interactions in live animals. Following infection with A. fumigatus, innate phagocyte populations exhibit clear preferences for different fungal morphologies: macrophages rapidly phagocytose conidia and form aggregates around hyphae, while the neutrophil response is dependent upon the presence of hyphae. Depletion of macrophages rendered host larvae susceptible to invasive disease. Moreover, a zebrafish model of human leukocyte adhesion deficiency with impaired neutrophil function also resulted in invasive disease and impaired host survival. In contrast, macrophage-deficient but not neutrophil-deficient larvae exhibited attenuated disease following challenge with a less virulent (ΔlaeA) strain of A. fumigatus, which has defects in secondary metabolite production. Taking these results together, we have established a new vertebrate model for studying innate immune responses to A. fumigatus that reveals distinct roles for neutrophils and macrophages in mediating host defense against IA. Copyright © 2014, American Society for Microbiology. All Rights Reserved.

  17. Analysis of hydraulic fracturing flowback and produced waters using accurate mass: identification of ethoxylated surfactants.

    PubMed

    Thurman, E Michael; Ferrer, Imma; Blotevogel, Jens; Borch, Thomas

    2014-10-07

    Two series of ethylene oxide (EO) surfactants, polyethylene glycols (PEGs from EO3 to EO33) and linear alkyl ethoxylates (LAEs C-9 to C-15 with EO3-EO28), were identified in hydraulic fracturing flowback and produced water using a new application of the Kendrick mass defect and liquid chromatography/quadrupole-time-of-flight mass spectrometry. The Kendrick mass defect differentiates the proton, ammonium, and sodium adducts in both singly and doubly charged forms. A structural model of adduct formation is presented, and binding constants are calculated, which is based on a spherical cagelike conformation, where the central cation (NH4(+) or Na(+)) is coordinated with ether oxygens. A major purpose of the study was the identification of the ethylene oxide (EO) surfactants and the construction of a database with accurate masses and retention times in order to unravel the mass spectral complexity of surfactant mixtures used in hydraulic fracturing fluids. For example, over 500 accurate mass assignments are made in a few seconds of computer time, which then is used as a fingerprint chromatogram of the water samples. This technique is applied to a series of flowback and produced water samples to illustrate the usefulness of ethoxylate "fingerprinting", in a first application to monitor water quality that results from fluids used in hydraulic fracturing.

  18. An Extremely Rich Group Of Starbursts And Agns At A Z=3.1 Proto-Cluster Core

    NASA Astrophysics Data System (ADS)

    Umehata, Hideki

    2017-06-01

    The environment where galaxies inhabit is expected to play a critical role in shaping their evolution. Galaxies and nuclei in the dense environment at high redshift (i.e., proto-clusters) provide a good laboratory to investigate the accelerated, most extreme evolution of galaxies at a given epoch. Using ALMA band 3 and band 6, we mapped a 2'x3' region within the node at the junction of the 50 Mpc-scale filamentary three-dimensional structure traced by Lyman-alpha emitters (LAEs) in this field. We obtained 18 robustly detected 1.1mm sources (here after submillimeter galaxies, SMGs) with a signal-to-noise ratio (SNR) >5. We also detected CO(3-2) line from 8 SMGs, which in general shows relatively extended structure. Totally 12 ALMA SMGs have spectroscopic redshifts of z=3.09 and six of them host a X-ray luminous active galactic nuclei (AGN). We also find that multiple z=3.09 ALMA SMGs contribute to two AzTEC sources, supporting that interaction may be responsible for a significant fraction of multiplicity in single-dish sources. Our results suggest that the vigorous star formation activity and the growth of super massive black holes (SMBHs) occurred simultaneously in the densest regions at z 3, which is likely to correspond to the most active historical phase of the massive galaxy population found in the core of the clusters in the present universe.

  19. Citrate-Coated Silver Nanoparticles Growth-Independently Inhibit Aflatoxin Synthesis in Aspergillus parasiticus.

    PubMed

    Mitra, Chandrani; Gummadidala, Phani M; Afshinnia, Kamelia; Merrifield, Ruth C; Baalousha, Mohammed; Lead, Jamie R; Chanda, Anindya

    2017-07-18

    Manufactured silver nanoparticles (Ag NPs) have long been used as antimicrobials. However, little is known about how these NPs affect fungal cell functions. While multiple previous studies reveal that Ag NPs inhibit secondary metabolite syntheses in several mycotoxin producing filamentous fungi, these effects are associated with growth repression and hence need sublethal to lethal NP doses, which besides stopping fungal growth, can potentially accumulate in the environment. Here we demonstrate that citrate-coated Ag NPs of size 20 nm, when applied at a selected nonlethal dose, can result in a >2 fold inhibition of biosynthesis of the carcinogenic mycotoxin and secondary metabolite, aflatoxin B 1 in the filamentous fungus and an important plant pathogen, Aspergillus parasiticus, without inhibiting fungal growth. We also show that the observed inhibition was not due to Ag ions, but was specifically associated with the mycelial uptake of Ag NPs. The NP exposure resulted in a significant decrease in transcript levels of five aflatoxin genes and at least two key global regulators of secondary metabolism, laeA and veA, with a concomitant reduction of total reactive oxygen species (ROS). Finally, the depletion of Ag NPs in the growth medium allowed the fungus to regain completely its ability of aflatoxin biosynthesis. Our results therefore demonstrate the feasibility of Ag NPs to inhibit fungal secondary metabolism at nonlethal concentrations, hence providing a novel starting point for discovery of custom designed engineered nanoparticles that can efficiently prevent mycotoxins with minimal risk to health and environment.

  20. Recovering the systemic redshift of galaxies from their Lyman-alpha line profile

    NASA Astrophysics Data System (ADS)

    Verhamme, A.; Garel, T.; Ventou, E.; Contini, T.; Bouché, N.; Herenz, E. C.; Richard, J.; Bacon, R.; Schmidt, K. B.; Maseda, M.; Marino, R. A.; Brinchmann, J.; Cantalupo, S.; Caruana, J.; Clément, B.; Diener, C.; Drake, A. B.; Hashimoto, T.; Inami, H.; Kerutt, J.; Kollatschny, W.; Leclercq, F.; Patrício, V.; Schaye, J.; Wisotzki, L.; Zabl, J.

    2018-04-01

    The Lyman alpha (Lyα) line of Hydrogen is a prominent feature in the spectra of star-forming galaxies, usually redshifted by a few hundreds of km s-1 compared to the systemic redshift. This large offset hampers follow-up surveys, galaxy pair statistics and correlations with quasar absorption lines when only Lyα is available. We propose diagnostics that can be used to recover the systemic redshift directly from the properties of the Lyα line profile. We use spectroscopic observations of Lyman-Alpha Emitters (LAEs) for which a precise measurement of the systemic redshift is available. Our sample contains 13 sources detected between z ≈ 3 and z ≈ 6 as part of various Multi Unit Spectroscopic Explorer (MUSE) Guaranteed Time Observations (GTO). We also include a compilation of spectroscopic Lyα data from the literature spanning a wide redshift range (z ≈ 0 - 8). First, restricting our analysis to double-peaked Lyα spectra, we find a tight correlation between the velocity offset of the red peak with respect to the systemic redshift, V_peak^red, and the separation of the peaks. Secondly, we find a correlation between V_peak^red and the full width at half maximum of the Lyα line. Fitting formulas, to estimate systemic redshifts of galaxies with an accuracy of ≤100 km s-1 when only the Lyα emission line is available, are given for the two methods.

  1. Identifying hazards associated with lava deltas

    USGS Publications Warehouse

    Poland, Michael P.; Orr, Tim R.

    2014-01-01

    Lava deltas, formed where lava enters the ocean and builds a shelf of new land extending from the coastline, represent a significant local hazard, especially on populated ocean island volcanoes. Such structures are unstable and prone to collapse—events that are often accompanied by small explosions that can deposit boulders and cobbles hundreds of meters inland. Explosions that coincide with collapses of the East Lae ‘Apuki lava delta at Kīlauea Volcano, Hawai‘i, during 2005–2007 followed an evolutionary progression mirroring that of the delta itself. A collapse that occurred when the lava–ocean entry was active was associated with a blast of lithic blocks and dispersal of spatter and fine, glassy tephra. Shortly after delta growth ceased, a collapse exposed hot rock to cold ocean water, resulting in an explosion composed entirely of lithic blocks and lapilli. Further collapse of the delta after several months of inactivity, by which time it had cooled significantly, resulted in no recognizable explosion deposit. Seaward displacement and subsidence of the coastline immediately inland of the delta was measured by both satellite and ground-based sensors and occurred at rates of several centimeters per month even after the lava–ocean entry had ceased. The anomalous deformation ended only after complete collapse of the delta. Monitoring of ground deformation may therefore provide an indication of the potential for delta collapse, while the hazard associated with collapse can be inferred from the level of activity, or the time since the last activity, on the delta.

  2. A Novel C2H2 Transcription Factor that Regulates gliA Expression Interdependently with GliZ in Aspergillus fumigatus

    PubMed Central

    Schoberle, Taylor J.; Nguyen-Coleman, C. Kim; Herold, Jennifer; Yang, Ally; Weirauch, Matt; Hughes, Timothy R.; McMurray, John S.; May, Gregory S.

    2014-01-01

    Secondary metabolites are produced by numerous organisms and can either be beneficial, benign, or harmful to humans. Genes involved in the synthesis and transport of these secondary metabolites are frequently found in gene clusters, which are often coordinately regulated, being almost exclusively dependent on transcription factors that are located within the clusters themselves. Gliotoxin, which is produced by a variety of Aspergillus species, Trichoderma species, and Penicillium species, exhibits immunosuppressive properties and has therefore been the subject of research for many laboratories. There have been a few proteins shown to regulate the gliotoxin cluster, most notably GliZ, a Zn2Cys6 binuclear finger transcription factor that lies within the cluster, and LaeA, a putative methyltransferase that globally regulates secondary metabolism clusters within numerous fungal species. Using a high-copy inducer screen in A. fumigatus, our lab has identified a novel C2H2 transcription factor, which plays an important role in regulating the gliotoxin biosynthetic cluster. This transcription factor, named GipA, induces gliotoxin production when present in extra copies. Furthermore, loss of gipA reduces gliotoxin production significantly. Through protein binding microarray and mutagenesis, we have identified a DNA binding site recognized by GipA that is in extremely close proximity to a potential GliZ DNA binding site in the 5′ untranslated region of gliA, which encodes an efflux pump within the gliotoxin cluster. Not surprisingly, GliZ and GipA appear to work in an interdependent fashion to positively control gliA expression. PMID:24784729

  3. Gibepyrone Biosynthesis in the Rice Pathogen Fusarium fujikuroi Is Facilitated by a Small Polyketide Synthase Gene Cluster*

    PubMed Central

    Janevska, Slavica; Arndt, Birgit; Niehaus, Eva-Maria; Burkhardt, Immo; Rösler, Sarah M.; Brock, Nelson L.; Humpf, Hans-Ulrich; Dickschat, Jeroen S.; Tudzynski, Bettina

    2016-01-01

    The 2H-pyran-2-one gibepyrone A and its oxidized derivatives gibepyrones B–F have been isolated from the rice pathogenic fungus Fusarium fujikuroi already more than 20 years ago. However, these products have not been linked to the respective biosynthetic genes, and therefore, their biosynthesis has not yet been analyzed on a molecular level. Feeding experiments with isotopically labeled precursors clearly supported a polyketide origin for the formal monoterpenoid gibepyrone A, whereas the terpenoid pathway could be excluded. Targeted gene deletion verified that the F. fujikuroi polyketide synthase PKS13, designated Gpy1, is responsible for gibepyrone A biosynthesis. Next to Gpy1, the ATP-binding cassette transporter Gpy2 is encoded by the gibepyrone gene cluster. Gpy2 was shown to have only a minor impact on the actual efflux of gibepyrone A out of the cell. Instead, we obtained evidence that Gpy2 is involved in gene regulation as it represses GPY1 gene expression. Thus, GPY1 was up-regulated and gibepyrone A production was enhanced both extra- and intracellularly in Δgpy2 mutants. Furthermore, expression of GPY genes is strictly repressed by members of the fungus-specific velvet complex, Vel1, Vel2, and Lae1, whereas Sge1, a major regulator of secondary metabolism in F. fujikuroi, affects gibepyrone biosynthesis in a positive manner. The gibepyrone A derivatives gibepyrones B and D were shown to be produced by cluster-independent P450 monooxygenases, probably to protect the fungus from the toxic product. In contrast, the formation of gibepyrones E and F from gibepyrone A is a spontaneous process and independent of enzymatic activity. PMID:27856636

  4. Sensing sheets based on large area electronics for fatigue crack detection

    NASA Astrophysics Data System (ADS)

    Yao, Yao; Glisic, Branko

    2015-03-01

    Reliable early-stage damage detection requires continuous structural health monitoring (SHM) over large areas of structure, and with high spatial resolution of sensors. This paper presents the development stage of prototype strain sensing sheets based on Large Area Electronics (LAE), in which thin-film strain gauges and control circuits are integrated on the flexible electronics and deposited on a polyimide sheet that can cover large areas. These sensing sheets were applied for fatigue crack detection on small-scale steel plates. Two types of sensing-sheet interconnects were designed and manufactured, and dense arrays of strain gauge sensors were assembled onto the interconnects. In total, four (two for each design type) strain sensing sheets were created and tested, which were sensitive to strain at virtually every point over the whole sensing sheet area. The sensing sheets were bonded to small-scale steel plates, which had a notch on the boundary so that fatigue cracks could be generated under cyclic loading. The fatigue tests were carried out at the Carleton Laboratory of Columbia University, and the steel plates were attached through a fixture to the loading machine that applied cyclic fatigue load. Fatigue cracks then occurred and propagated across the steel plates, leading to the failure of these test samples. The strain sensor that was close to the notch successfully detected the initialization of fatigue crack and localized the damage on the plate. The strain sensor that was away from the crack successfully detected the propagation of fatigue crack based on the time history of measured strain. Overall, the results of the fatigue tests validated general principles of the strain sensing sheets for crack detection.

  5. A Proteomic Approach to Investigating Gene Cluster Expression and Secondary Metabolite Functionality in Aspergillus fumigatus

    PubMed Central

    Owens, Rebecca A.; Hammel, Stephen; Sheridan, Kevin J.; Jones, Gary W.; Doyle, Sean

    2014-01-01

    A combined proteomics and metabolomics approach was utilised to advance the identification and characterisation of secondary metabolites in Aspergillus fumigatus. Here, implementation of a shotgun proteomic strategy led to the identification of non-redundant mycelial proteins (n = 414) from A. fumigatus including proteins typically under-represented in 2-D proteome maps: proteins with multiple transmembrane regions, hydrophobic proteins and proteins with extremes of molecular mass and pI. Indirect identification of secondary metabolite cluster expression was also achieved, with proteins (n = 18) from LaeA-regulated clusters detected, including GliT encoded within the gliotoxin biosynthetic cluster. Biochemical analysis then revealed that gliotoxin significantly attenuates H2O2-induced oxidative stress in A. fumigatus (p>0.0001), confirming observations from proteomics data. A complementary 2-D/LC-MS/MS approach further elucidated significantly increased abundance (p<0.05) of proliferating cell nuclear antigen (PCNA), NADH-quinone oxidoreductase and the gliotoxin oxidoreductase GliT, along with significantly attenuated abundance (p<0.05) of a heat shock protein, an oxidative stress protein and an autolysis-associated chitinase, when gliotoxin and H2O2 were present, compared to H2O2 alone. Moreover, gliotoxin exposure significantly reduced the abundance of selected proteins (p<0.05) involved in de novo purine biosynthesis. Significantly elevated abundance (p<0.05) of a key enzyme, xanthine-guanine phosphoribosyl transferase Xpt1, utilised in purine salvage, was observed in the presence of H2O2 and gliotoxin. This work provides new insights into the A. fumigatus proteome and experimental strategies, plus mechanistic data pertaining to gliotoxin functionality in the organism. PMID:25198175

  6. The Development of Replicated Optical Integral Field Spectrographs and their Application to the Study of Lyman-alpha Emission at Moderate Redshifts

    NASA Astrophysics Data System (ADS)

    Chonis, Taylor Steven

    In the upcoming era of extremely large ground-based astronomical telescopes, the design of wide-field spectroscopic survey instrumentation has become increasingly complex due to the linear growth of instrument pupil size with telescope diameter for a constant spectral resolving power. The upcoming Visible Integral field Replicable Unit Spectrograph (VIRUS), a baseline array of 150 copies of a simple integral field spectrograph that will be fed by 3:36 x 104 optical fibers on the upgraded Hobby-Eberly Telescope (HET) at McDonald Observatory, represents one of the first uses of large-scale replication to break the relationship between instrument pupil size and telescope diameter. By dividing the telescope's field of view between a large number of smaller and more manageable instruments, the total information grasp of a traditional monolithic survey spectrograph can be achieved at a fraction of the cost and engineering complexity. To highlight the power of this method, VIRUS will execute the HET Dark Energy Experiment (HETDEX) and survey & 420 degrees2 of sky to an emission line flux limit of ˜ 10-17 erg s-1 cm -2 to detect ˜ 106 Lyman-alpha emitting galaxies (LAEs) as probes of large-scale structure at redshifts of 1:9 < z < 3:5. HETDEX will precisely measure the evolution of dark energy at that epoch, and will simultaneously amass an LAE sample that will be unprecedented for extragalactic astrophysics at the redshifts of interest. Large-scale replication has clear advantages to increasing the total information grasp of a spectrograph, but there are also challenges. In this dissertation, two of these challenges with respect to VIRUS are detailed. First, the VIRUS cryogenic system is discussed, specifically the design and tests of a novel thermal connector and internal camera croygenic components that link the 150 charge-coupled device detectors to the instrument's liquid nitrogen distribution system. Second, the design, testing, and mass production of the suite of

  7. Gα-cAMP/PKA pathway positively regulates pigmentation, chaetoglobosin A biosynthesis and sexual development in Chaetomium globosum

    PubMed Central

    Hu, Yang; Chen, Longfei; Akhberdi, Oren; Yu, Xi; Liu, Yanjie; Zhu, Xudong

    2018-01-01

    Sensing the environmental signals, the canonical Gα-cAMP/PKA pathway modulates mycelial growth and development, and negatively regulates some secondary metabolism in filamentous fungi, e.g. aflatoxin in Aspergillus nidulans. Here we report the characterization of this signaling pathway in Chaetomium globosum, a widely spread fungus known for synthesizing abundant secondary metabolites, e.g. chaetoglobosin A (ChA). RNAi-mediated knockdown of a putative Gα-encoding gene gna-1, led to plural changes in phenotype, e.g. albino mycelium, significant restriction on perithecium development and decreased production of ChA. RNA-seq profiling and qRT-PCR verified significantly fall in expression of corresponding genes, e.g. pks-1 and CgcheA. These defects could be restored by simultaneous knock-down of the pkaR gene encoding a regulatory subunit of cAMP-dependent protein kinase A (PKA), suggesting that pkaR had a negative effect on the above mentioned traits. Confirmatively, the intracellular level of cAMP in wild-type strain was about 3.4-fold to that in gna-1 silenced mutant pG14, and addition of a cAMP analog, 8-Br-cAMP, restored the same defects, e.g., the expression of CgcheA. Furthermore, the intracellular cAMP in gna-1 and pkaR double silenced mutant was approaching the normal level. The following activity inhibition experiment proved that the expression of CgcheA was indeed regulated by PKA. Down-regulation of LaeA/VeA/SptJ expression in gna-1 mutant was also observed, implying that Gα signaling may crosstalk to other regulatory pathways. Taken together, this study proposes that the heterotrimeric Gα protein-cAMP/PKA signaling pathway positively mediates the sexual development, melanin biosynthesis, and secondary metabolism in C. globosum. PMID:29652900

  8. Faint submillimeter galaxies revealed by multifield deep ALMA observations: number counts, spatial clustering, and a dark submillimeter line emitter

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Ono, Yoshiaki; Ouchi, Masami; Momose, Rieko

    2014-11-01

    We present the statistics of faint submillimeter/millimeter galaxies (SMGs) and serendipitous detections of a submillimeter/millimeter line emitter (SLE) with no multi-wavelength continuum counterpart revealed by the deep ALMA observations. We identify faint SMGs with flux densities of 0.1-1.0 mJy in the deep Band-6 and Band-7 maps of 10 independent fields that reduce cosmic variance effects. The differential number counts at 1.2 mm are found to increase with decreasing flux density down to 0.1 mJy. Our number counts indicate that the faint (0.1-1.0 mJy, or SFR{sub IR} ∼ 30-300 M {sub ☉} yr{sup –1}) SMGs contribute nearly a half of themore » extragalactic background light (EBL), while the remaining half of the EBL is mostly contributed by very faint sources with flux densities of <0.1 mJy (SFR{sub IR} ≲ 30 M {sub ☉} yr{sup –1}). We conduct counts-in-cells analysis with multifield ALMA data for the faint SMGs, and obtain a coarse estimate of galaxy bias, b {sub g} < 4. The galaxy bias suggests that the dark halo masses of the faint SMGs are ≲ 7 × 10{sup 12} M {sub ☉}, which is smaller than those of bright (>1 mJy) SMGs, but consistent with abundant high-z star-forming populations, such as sBzKs, LBGs, and LAEs. Finally, we report the serendipitous detection of SLE-1, which has no continuum counterparts in our 1.2 mm-band or multi-wavelength images, including ultra deep HST/WFC3 and Spitzer data. The SLE has a significant line at 249.9 GHz with a signal-to-noise ratio of 7.1. If the SLE is not a spurious source made by the unknown systematic noise of ALMA, the strong upper limits of our multi-wavelength data suggest that the SLE would be a faint galaxy at z ≳ 6.« less

  9. Three Campaigns to Image the Earth's Interior Using Mermaids (Mobile Earthquake Recorder in Marine Areas by Indepen-dent Divers).

    NASA Astrophysics Data System (ADS)

    Pazmino, A.; Bonnieux, S.; Joubert, C.; Gonzales, N.; Hello, Y.; Nolet, G.

    2014-12-01

    Mermaids have been developed to improve seismic data coverage in the oceanic domain for imaging of the Earth's interior. Though housed in conventional Argo-type floats, hardware and software was developed to analyze acoustic signals and determine whether an earthquake has been recorded, and whether the Mermaid should to come up to the surface and transmit to the satellite. In contrast to the passive Argo floats, Mermaids are essentially floating computers that decide for themselves what to do. After testing in the Mediterranean and Indian Ocean and improving the concept for more than a year, we recently started two fully scientific experiments using Mermaids. In cooperation with Inocar, we deployed a fleet of 10 Mermaids in May 2014 around the Galapagos islands from the LAE Sirius to study the suspected mantle plume beneath these islands. We are interested in plumes because we do not understand very well how the mantle has retained an almost constant temperature for three or four billion years, an essential condition for life to develop. The depth of mantle plumes is an important unknown, because it may tell us how well the lower mantle is able to transmit heat into the upper mantle. A second experiment is taking place in the Ligurian Sea. This basin opened with a rifting phase in late Oligocene. The rifting phase of the Ligurian basin is followed by the Corsica - Sardinia block counterclockwise rotation, but the deeper causes of this are still poorly understood. Three Mermaids are deployed, and re-deployed after drifting too far west, to augment the P arrivals observed for 6 months with 5 OBS's during the 2008 Grosmarin campaign. The experience obtained with this first generation of Mermaids has led to the development of a new multidisciplinary float (Multimermaid), which is programmable, able to carry up to 8 sensors to a depth of 3000 m, and with a duration of at least five years.

  10. Flight Validation of the Thermal Propellant Gauging Method used at EADS Astrium

    NASA Astrophysics Data System (ADS)

    Dandaleix, L.; Ounougha, L.; Jallade, S.

    2004-10-01

    EADS Astrium recently met a major milestone in the field of propellant gauging with the first reorbitation of an Eurostar tanks equipped satellite. It proved successful determining the remaining available propellant mass for spacecraft displacement beyond the customer specified graveyard orbit; thus demonstrating its expertness in Propellant Gauging in correlation with tank residual mass minimization. A critical parameter in satellite operational planning is indeed the accurate knowledge of the on-board remaining propellant mass; basically for the commercial telecommunication missions, where it is the major criterion for lifetime maximization. To provide an accurate and reliable process for measurement of this propellant mass throughout lifetime, EADS Astrium uses a Combination of two independent techniques: The Dead Reckoning Method (maximum accuracy at BOL), based on thrusters flow rate prediction &the Thermal Propellant Gauging Technique, deriving the propellant mass from the tank thermal capacity (Absolute gauging method, with increasing accuracy along lifetime). Then, the present article shows the recent flight validation of the Gauging method obtained for Eurostar E2000 propellant tanks including the validation of the different thermodynamic models. ABBREVIATIONS &ACRONYMS BOL, MOL, EOL: Beginning, Middle &End of Life Cempty: Empty tank thermal inertia [J/K] Chelium: Helium thermal inertia [J/K] Cpropellant: Propellant thermal inertia [J/K] Ct = C1+C2: Total tank thermal inertia (Subscript for upper node and for lower node) [J/K] CPS: Combined Propulsion System DR: Dead Reckoning FM: Flight Model LAE: Liquid Apogee Engine lsb: Least significant byte M0: TPGS Uncertainty component linked to Cempty mox, mfuel: Propellant mass of oxidiser &fuel [kg] Pox, Pfuel: Pressure of oxidiser &fuel [bar] PTA: Propellant Tank Assembly Q: Heater power [W] Qox, Qfuel: Mass flow rate of oxidiser &fuel [kg/s] RCT: Reaction Control Thrusters T0: Spacecraft platform equilibrium

  11. Transcriptomic profiles of Aspergillus flavus CA42, a strain that produces small sclerotia, by decanal treatment and after recovery.

    PubMed

    Chang, Perng-Kuang; Scharfenstein, Leslie L; Mack, Brian; Yu, Jiujiang; Ehrlich, Kenneth C

    2014-07-01

    Aspergillus flavus is a ubiquitous saprophyte and is capable of producing many secondary metabolites including the carcinogenic aflatoxins. The A. flavus population that produces small sclerotia (S strain) has been implicated as the culprit for persistent aflatoxin contamination in field crops. We investigated how the plant volatile decanal, a C10 fatty aldehyde, affected the growth and development of the S strain A. flavus. Decanal treatment yielded fluffy variants lacking sclerotia and conidia and exhibiting a dosage-dependent radial colony growth. We used RNA-Seq analysis to examine transcriptomic changes caused by decanal and after removal of decanal. Mature sclerotia contained only 80% of the total transcripts detected in all samples in comparison to 94% for the decanal treated culture. Gene ontology (GO) analysis showed that decanal treatment increased expression of genes involved in oxidoreductase activity, cellular carbohydrate metabolism, alcohol metabolism and aflatoxin biosynthesis. The treatment affected cellular components associated with cell wall, and gene expression of glucanases, α-amylases, pectinesterase and peptidase required for its biosynthesis was increased. After decanal was removed, the culture resumed sclerotial production. Moreover, its GO terms significantly overlapped with those of the untreated culture; five of the enriched molecular functions, oxidoreductase activity, monooxygenase activity, electron carrier activity, heme binding, and iron binding were found in the untreated culture. The GO term of cellular component enriched was mainly integral protein constituents of the membrane. The results suggested that decanal halted development at the vegetative state rendering the fungus unable to produce conidia and sclerotia. The induced fluffy phenotype could be related to lower transcript abundance of flbB, flbD, and flbE but not to veA expression. Increased abundance of the laeA transcript in the treated culture correlated with early

  12. Neotectonic Geomorphology of the Owen Stanley Oblique-slip Fault System, Eastern Papua New Guinea

    NASA Astrophysics Data System (ADS)

    Watson, L.; Mann, P.; Taylor, F.

    2003-12-01

    streams by 0.5 to 1.2 km. The northern edge of the OSFS merges with the Ramu-Markham strike-slip fault near Lae. SW tilting of the footwall block (Papuan Peninsula) is responsible for the asymmetrical topographic profile of the peninsula and drowned topography along the southern coast of the peninsula.

  13. 40Ar/39Ar geochronology of submarine Mauna Loa volcano, Hawaii

    NASA Astrophysics Data System (ADS)

    Jicha, Brian R.; Rhodes, J. Michael; Singer, Brad S.; Garcia, Michael O.

    2012-09-01

    constrain the eruption of the Ninole Basalts from 227 to 108 ka and provide maximum estimates on the timing of the Ka Lae and South Kona landslides.

  14. A Geochemical Study of Magmatic Processes and Evolution along the Submarine Southwest Rift zone of Mauna Loa Volcano, Hawaii

    NASA Astrophysics Data System (ADS)

    Rhodes, J. M.; Garcia, M. O.; Weis, D.; Trusdell, F. A.; Vollinger, M. J.

    2003-12-01

    Mauna Loa's southwest rift zone (SWR) extends for 102 km from its summit caldera, at an elevation of 4,170 m above sea level, to submarine depths of over 4,500 m. About 65% of the rift zone is subaerial and 35% submarine. Recent sampling with the Jason II submersible of the `mile-high' (1800 m) Ka Lae submarine landslide scarp and the deepest section of the rift zone, in conjunction with previous submersible and dredge-haul collecting, provides petrological and geochemical understanding of rift zone processes, as well as a record of Mauna Loa's eruptive history extending back about 400 ka. The major and trace element trends of the submarine lavas are remarkably similar to those of historical and young prehistoric lavas (<31 ka) erupted along the subaerial SWR. We take this to imply that magma-forming processes have remained relatively constant over much of the volcano's recorded eruptive history. However, the distribution of samples along these trends has varied, and is correlated with elevation. There are very few picrites (>12% MgO) among the subaerial lavas, and compositions tend to cluster around 6.8-8.0% MgO. In contrast, picritic lavas are extremely abundant in the submarine samples, increasing in frequency with depth, especially below 1200 m. These observations support earlier interpretations that the submarine lavas are derived directly from deeper levels in the magma column, and that magmas from a shallow, steady-state, magma reservoir are of uncommon at these depths. Isotopic ratios of Pb and Sr in the submarine lavas, in conjunction with Nb/Y and Zr/Nb ratios, extend from values that are identical with subaerial historical Mauna Loa lavas to lavas with markedly lower 87Sr/86Sr and higher 206Pb/204Pb isotopic ratios. As yet, we see no correlation with depth or age, but the implications are that, in the past, the plume source of Mauna Loa magmas was more variable than in the last 31 ka, and contained a greater proportion of the Kea component. *Team members

  15. New Insights into the present-day kinematics of the central and western Papua New Guinea from GPS

    NASA Astrophysics Data System (ADS)

    Koulali, A.; Tregoning, P.; McClusky, S.; Stanaway, R.; Wallace, L.; Lister, G.

    2015-08-01

    New Guinea is a region characterized by rapid oblique convergence between the Pacific and Australian tectonic plates. The detailed tectonics of the region, including the partitioning of relative block motions and fault slip rates within this complex boundary plate boundary zone are still not well understood. In this study, we quantify the distribution of the deformation throughout the central and western parts of Papua New Guinea (PNG) using 20 yr of GPS data (1993-2014). We use an elastic block model to invert the regional GPS velocities as well as earthquake slip vectors for the location and rotation rates of microplate Euler poles as well as fault slip parameters in the region. Convergence between the Pacific and the Australian plates is accommodated in northwestern PNG largely by the New Guinea Trench with rates exceeding 90 mm yr-1, indicating that this is the major active interplate boundary. However, some convergent deformation is partitioned into a shear component with ˜12 per cent accommodated by the Bewani-Torricelli fault zone and the southern Highlands Fold-and-Thrust Belt. New GPS velocities in the eastern New Guinea Highlands region have led to the identification of the New Guinea Highlands and the Papuan Peninsula being distinctly different blocks, separated by a boundary through the Aure Fold-and-Thrust Belt complex which accommodates an estimated 4-5 mm yr-1 of left-lateral and 2-3 mm yr-1 of convergent motion. This implies that the Highlands Block is rotating in a clockwise direction relative to the rigid Australian Plate, consistent with the observed transition to left-lateral strike-slip regime observed in western New Guinea Highlands. We find a better fit of our block model to the observed velocities when assigning the current active boundary between the Papuan Peninsula and the South Bismark Block to be to the north of the city of Lae on the Gain Thrust, rather than on the more southerly Ramu-Markham fault as previously thought. This may

  16. Slicing COSMOS with SC4K: the evolution of typical Ly α emitters and the Ly α escape fraction from z ˜ 2 to 6

    NASA Astrophysics Data System (ADS)

    Sobral, David; Santos, Sérgio; Matthee, Jorryt; Paulino-Afonso, Ana; Ribeiro, Bruno; Calhau, João; Khostovan, Ali A.

    2018-06-01

    We present and explore deep narrow- and medium-band data obtained with the Subaru and the Isaac Newton Telescopes in the ˜2 deg2 COSMOS field. We use these data as an extremely wide, low-resolution (R ˜ 20-80) Integral Field Unit survey to slice through the COSMOS field and obtain a large sample of ˜4000 Ly α emitters (LAEs) from z ˜ 2 to 6 in 16 redshift slices (SC4K). We present new Ly α luminosity functions (LFs) covering a comoving volume of ˜108 Mpc3. SC4K extensively complements ultradeep surveys, jointly covering over 4 dex in Ly α luminosity and revealing a global (2.5 < z < 6) synergy LF with α =-1.93^{+0.12}_{-0.12}, log _{10}Φ ^*_{Lyα }={-3.45^{+0.22}_{-0.29}} Mpc-3, and log _{10}L^*_{Lyα }={42.93^{+0.15}_{-0.11}} erg s-1. The Schechter component of the Ly α LF reveals a factor ˜5 rise in L^*_Lyα and a ˜7 × decline in Φ ^*_{Lyα } from z ˜ 2 to 6. The data reveal an extra power-law (or Schechter) component above LLy α ≈ 1043.3 erg s-1 at z ˜ 2.2-3.5 and we show that it is partially driven by X-ray and radio active galactic nucleus (AGN), as their Ly α LF resembles the excess. The power-law component vanishes and/or is below our detection limits above z > 3.5, likely linked with the evolution of the AGN population. The Ly α luminosity density rises by a factor ˜2 from z ˜ 2 to 3 but is then found to be roughly constant (1.1^{+0.2}_{-0.2}× 10^{40} erg s-1 Mpc-3) to z ˜ 6, despite the ˜0.7 dex drop in ultraviolet (UV) luminosity density. The Ly α/UV luminosity density ratio rises from 4 ± 1 per cent to 30 ± 6 per cent from z ˜ 2.2 to 6. Our results imply a rise of a factor of ≈2 in the global ionization efficiency (ξion) and a factor ≈4 ± 1 in the Ly α escape fraction from z ˜ 2 to 6, hinting for evolution in both the typical burstiness/stellar populations and even more so in the typical interstellar medium conditions allowing Ly α photons to escape.

  17. Composition and Structure of Mauna Loa's Submarine West Flank, Hawaii

    NASA Astrophysics Data System (ADS)

    Borchers, D.; Morgan, J. K.; Clague, D. A.; Moore, G. F.

    2003-12-01

    layered slope strata overlie the upper flank to the south, and are truncated above the Ka Lae avalanche scar. The central bench to the north, sampled by the MBARI dives, shows only thin sediment cover above a poorly reflective interior. Strong deep reflections in both locations begin to resolve the underlying oceanic crust, as well as probable fault planes that may be responsible for flank deformation in this area. The abundance of volcaniclastic rocks with Mauna Loa affinities within the bench supports the idea that giant landslides from Mauna Loa were the source of much of the offshore debris. The stratal repetition, deformation fabrics, and cementation of the volcaniclastics also suggest that the rocks composing the bench were once deeply buried and have been subsequently exhumed by thrusting, most likely driven by deep volcanic spreading.

  18. The MUSE Hubble Ultra Deep Field Survey. VIII. Extended Lyman-α haloes around high-z star-forming galaxies

    NASA Astrophysics Data System (ADS)

    Leclercq, Floriane; Bacon, Roland; Wisotzki, Lutz; Mitchell, Peter; Garel, Thibault; Verhamme, Anne; Blaizot, Jérémy; Hashimoto, Takuya; Herenz, Edmund Christian; Conseil, Simon; Cantalupo, Sebastiano; Inami, Hanae; Contini, Thierry; Richard, Johan; Maseda, Michael; Schaye, Joop; Marino, Raffaella Anna; Akhlaghi, Mohammad; Brinchmann, Jarle; Carollo, Marcella

    2017-11-01

    We report the detection of extended Lyα haloes around 145 individual star-forming galaxies at redshifts 3 ≤ z ≤ 6 in the Hubble Ultra Deep Field observed with the Multi-Unit Spectroscopic Explorer (MUSE) at ESO-VLT. Our sample consists of continuum-faint (- 15 ≥ MUV ≥ -22) Lyα emitters (LAEs). Using a 2D, two-component (continuum-like and halo) decomposition of Lyα emission assuming circular exponential distributions, we measure scale lengths and luminosities of Lyα haloes. We find that 80% of our objects having reliable Lyα halo measurements show Lyα emission that is significantly more extended than the UV continuum detected by HST (by a factor ≈4 to >20). The median exponential scale length of the Lyα haloes in our sample is ≈4.5 kpc with a few haloes exceeding 10 kpc. By comparing the maximal detected extent of the Lyα emission with the predicted dark matter halo virial radii of simulated galaxies, we show that the detected Lyα emission of our selected sample of Lyα emitters probes a significant portion of the cold circum-galactic medium of these galaxies (>50% in average). This result therefore shows that there must be significant HI reservoirs in the circum-galactic medium and reinforces the idea that Lyα haloes are ubiquitous around high-redshift Lyα emitting galaxies. Our characterization of the Lyα haloes indicates that the majority of the Lyα flux comes from the halo (≈65%) and that their scale lengths seem to be linked to the UV properties of the galaxies (sizes and magnitudes). We do not observe a significant Lyα halo size evolution with redshift, although our sample for z> 5 is very small. We also explore the diversity of the Lyα line profiles in our sample and we find that the Lyα lines cover a large range of full width at half maximum (FWHM) from 118 to 512 km s-1. While the FWHM does not seem to be correlated to the Lyα scale length, most compact Lyα haloes and those that are not detected with high significance tend

  19. Analyzing the Signatures of High Red-shift Hydrogen: The Lyman Alpha and 21cm Emission Lines

    NASA Astrophysics Data System (ADS)

    Hansen, Matthew

    Hydrogen line emission is an important window on galaxy formation due to the large abundance of neutral hydrogen in the early Universe. This dissertation comprises two theoretical/computational studies of two types of hydrogen line emission: Lyman alpha emission and escape from young stellar populations, and 21cm radiation from neutral hydrogen clouds at the time of the first luminous objects. The Lyman alpha research concerns the radiative transfer of resonant line radiation from a central source escaping from a multi-phase medium appropriate to young star forming regions. To analyze the properties of this novel radiative transfer problem I develop new theoretical formulations of the problem, substantiated by physically accurate monte carlo simulations of photon scattering and absorption through multi-phase gas geometries. I find that the escape fraction of resonant line photons from young star forming regions--ionized gas filled with neutral hydrogen clouds with low dust content--can exceed the continuum photon escape fraction by up to an order of magnitude. Additionally, I study the effect of gas outflow on the line profile of escaping resonant photons. In light of these results, I discuss why a young normal stellar populations surrounded by a clumpy multi-phase gas outflow can explain the Lyman alpha spectra seen from high red-shift Lyman Alpha Emitters (LAEs). The 21cm research concerns the ionization evolution of the Intergalactic Medium (IGM) during the era of the first luminous objects in the Universe. Large radio-array observatories are currently being built to specifically detect the red-shifted 21cm radiation from neutral hydrogen at red-shifts z ˜ 12 - - 6; the output will be three dimensional maps of ionized regions across the plane of the sky at various red-shift depths. The signal in the resulting ionization maps will be limited by observational noise, mainly from foreground galactic emission in radio frequencies. The research presented here is a

  20. 40Ar/39Ar geochronology of submarine Mauna Loa volcano, Hawaii

    NASA Astrophysics Data System (ADS)

    Jicha, B.; Rhodes, J. M.; Singer, B. S.; Vollinger, M. J.; Garcia, M. O.

    2009-12-01

    A major impediment to our understanding of the nature and structure of the Hawaiian plume, and evaluating the competing plume models has been a lack of thick stratigraphic sections from which to obtain long temporal records of magmatic history. The Hawaii Scientific Drilling Project (HSDP) made a significant advance towards solving this problem by documenting the long-term magmatic evolution of Mauna Kea volcano on the Kea side of the plume. To evaluate comparable long-term magmatic history on the Loa side of the plume we collected a stratigraphically controlled sample suite using Jason and Pisces dives from three vertical transects of the 1.6 km high Kae Lae landslide scarp cut into Mauna Loa’s submarine southwest rift zone (SWR). We have undertaken an 40Ar/39Ar investigation of Mauna Loa’s growth history to integrate new geochronologic constraints with geochemical, and isotopic data, illuminating temporal trends within the Hawaiian plume. Obtaining precise 40Ar/39Ar ages from tholeiitic lavas younger than 500 ka containing only 0.2-0.6 wt.% K2O is challenging due to the extremely low radiogenic 40Ar contents. Furnace incremental heating experiments of groundmass separated from 15 submarine lavas have yielded four new age determinations (a 27% success rate). These four lavas give concordant age spectra with plateau and isochron ages that agree with stratigraphy. We also analyzed two previously-dated subaerial Mauna Kea tholeiites from the HSDP-2 drill core, to assess inter-laboratory reproducibility and calibrate our results to those obtained for the core. Two experiments on sample SR413-4.0 and one experiment from SR781-21.2 gave weighted mean plateau ages of 364 ± 95 ka and 473 ± 109, respectively, which are indistinguishable from the published 40Ar/39Ar ages of 390 ± 70 ka and 482 ± 67. Although Sharp and Renne (2005) preferred isochron ages for the submarine Mauna Kea tholeiites recovered from HSDP, we find that submarine Mauna Loa lavas contain

  1. Mapping fire effects on ash and soil properties. Current knowledge and future perspectives.

    NASA Astrophysics Data System (ADS)

    Pereira, Paulo; Cerda, Artemi; Strielko, Irina

    2014-05-01

    scales and the future perspectives. References Finley, C.D., Glenn, N.F. (2010) Fire and vegetation type effects on soil hydrophobicity and infiltration in the sagebrussh-steppe: II. Hyperspectral analysis. Journal of Arid Environments, 74: 660-666. Fox, D.A., Maselli, F., Carrega, P. (2008) Using SPOT images and field sampling to map burn severity and vegetation factors affecting post-fire erosion risk. Catena, 75: 326-335. Gimeno-Garcia. E., Andreu., V., Rubio, J.L. (2004) Spatial patterns of soil temperatures during experiemntal fires. Geoderma, 118: 17-34. Hirobe, M., Tokushi, N., Wachrinrat, C., Takeda, H. (2003) Fire history influences on the spatial heterogeneity of soil nitrogen transformations in three adjacent stands in a dry tropical forest in Thailand. Plant and Soil, 249: 309-318. Kokaly, R.F., Rockwell, B.W., Haire, S.L., King, T.V.V. (2007) Characterization of post fire surface cover, soils, and burn severity at the Cerro Grande fire, New Mexico, using hyperspectral and multispectral remote sensing. Remote Sensing of the Environment, 106: 305-325. Lewis, S.A., Hudak, A.T., Ottmar, R.D., Robichaud, P.R., Lentile, L.B., Hood, S.M., Cronan, J.B., Morgan, P. (2012) Using hyperspectral imagery to estimate forest floor consumption from wildfire in boreal forests of Alaska. International Journal of Wildland Fire, 20: 255-271. Lewis, S.A., Robichaud, P.R., Frazier, B.E., Wu, J.Q., Laes, D.Y.M. (2008) Using hyperspectral imagery to predict post-wildfire soil repellency. Geomorphology, 98, 192-205. Miller, J.D., Yool, S. (2002) Mapping forest post-fire canopy consumption in several overstory types using multi-temporal Landsat TM and ETM data. Remote Sensing of the Environment, 82: 481-496. Outeiro, L., Aspero, F., Ubeda, X. (2008) Geostatistical methods to study spatial variability of soil cation after a prescribed fire and rainfall. Catena, 74: 310-320. Parsons, A., Robichaud, P.R., Lewis, S.A., Napper, C., Clark, J.T. (2010) Field guide for mapping post-fire soil