Sample records for validation experiments showed

  1. 42 CFR 456.655 - Validation of showings.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 42 Public Health 4 2013-10-01 2013-10-01 false Validation of showings. 456.655 Section 456.655... Showing of an Effective Institutional Utilization Control Program § 456.655 Validation of showings. (a) The Administrator will periodically validate showings submitted under § 456.654. Validation procedures...

  2. 42 CFR 456.655 - Validation of showings.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 42 Public Health 4 2012-10-01 2012-10-01 false Validation of showings. 456.655 Section 456.655... Showing of an Effective Institutional Utilization Control Program § 456.655 Validation of showings. (a) The Administrator will periodically validate showings submitted under § 456.654. Validation procedures...

  3. 42 CFR 456.655 - Validation of showings.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 42 Public Health 4 2014-10-01 2014-10-01 false Validation of showings. 456.655 Section 456.655... Showing of an Effective Institutional Utilization Control Program § 456.655 Validation of showings. (a) The Administrator will periodically validate showings submitted under § 456.654. Validation procedures...

  4. 42 CFR 456.655 - Validation of showings.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 42 Public Health 4 2011-10-01 2011-10-01 false Validation of showings. 456.655 Section 456.655... Showing of an Effective Institutional Utilization Control Program § 456.655 Validation of showings. (a) The Administrator will periodically validate showings submitted under § 456.654. Validation procedures...

  5. 42 CFR 456.655 - Validation of showings.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... Administrator will not find an agency's showing satisfactory if the information obtained through his validation... 42 Public Health 4 2010-10-01 2010-10-01 false Validation of showings. 456.655 Section 456.655... Showing of an Effective Institutional Utilization Control Program § 456.655 Validation of showings. (a...

  6. Validation of RNAi Silencing Efficiency Using Gene Array Data shows 18.5% Failure Rate across 429 Independent Experiments.

    PubMed

    Munkácsy, Gyöngyi; Sztupinszki, Zsófia; Herman, Péter; Bán, Bence; Pénzváltó, Zsófia; Szarvas, Nóra; Győrffy, Balázs

    2016-09-27

    No independent cross-validation of success rate for studies utilizing small interfering RNA (siRNA) for gene silencing has been completed before. To assess the influence of experimental parameters like cell line, transfection technique, validation method, and type of control, we have to validate these in a large set of studies. We utilized gene chip data published for siRNA experiments to assess success rate and to compare methods used in these experiments. We searched NCBI GEO for samples with whole transcriptome analysis before and after gene silencing and evaluated the efficiency for the target and off-target genes using the array-based expression data. Wilcoxon signed-rank test was used to assess silencing efficacy and Kruskal-Wallis tests and Spearman rank correlation were used to evaluate study parameters. All together 1,643 samples representing 429 experiments published in 207 studies were evaluated. The fold change (FC) of down-regulation of the target gene was above 0.7 in 18.5% and was above 0.5 in 38.7% of experiments. Silencing efficiency was lowest in MCF7 and highest in SW480 cells (FC = 0.59 and FC = 0.30, respectively, P = 9.3E-06). Studies utilizing Western blot for validation performed better than those with quantitative polymerase chain reaction (qPCR) or microarray (FC = 0.43, FC = 0.47, and FC = 0.55, respectively, P = 2.8E-04). There was no correlation between type of control, transfection method, publication year, and silencing efficiency. Although gene silencing is a robust feature successfully cross-validated in the majority of experiments, efficiency remained insufficient in a significant proportion of studies. Selection of cell line model and validation method had the highest influence on silencing proficiency.

  7. CFD validation experiments for hypersonic flows

    NASA Technical Reports Server (NTRS)

    Marvin, Joseph G.

    1992-01-01

    A roadmap for CFD code validation is introduced. The elements of the roadmap are consistent with air-breathing vehicle design requirements and related to the important flow path components: forebody, inlet, combustor, and nozzle. Building block and benchmark validation experiments are identified along with their test conditions and measurements. Based on an evaluation criteria, recommendations for an initial CFD validation data base are given and gaps identified where future experiments could provide new validation data.

  8. Virtual experiments, physical validation: dental morphology at the intersection of experiment and theory

    PubMed Central

    Anderson, P. S. L.; Rayfield, E. J.

    2012-01-01

    Computational models such as finite-element analysis offer biologists a means of exploring the structural mechanics of biological systems that cannot be directly observed. Validated against experimental data, a model can be manipulated to perform virtual experiments, testing variables that are hard to control in physical experiments. The relationship between tooth form and the ability to break down prey is key to understanding the evolution of dentition. Recent experimental work has quantified how tooth shape promotes fracture in biological materials. We present a validated finite-element model derived from physical compression experiments. The model shows close agreement with strain patterns observed in photoelastic test materials and reaction forces measured during these experiments. We use the model to measure strain energy within the test material when different tooth shapes are used. Results show that notched blades deform materials for less strain energy cost than straight blades, giving insights into the energetic relationship between tooth form and prey materials. We identify a hypothetical ‘optimal’ blade angle that minimizes strain energy costs and test alternative prey materials via virtual experiments. Using experimental data and computational models offers an integrative approach to understand the mechanics of tooth morphology. PMID:22399789

  9. Validation of the revised Mystical Experience Questionnaire in experimental sessions with psilocybin.

    PubMed

    Barrett, Frederick S; Johnson, Matthew W; Griffiths, Roland R

    2015-11-01

    The 30-item revised Mystical Experience Questionnaire (MEQ30) was previously developed within an online survey of mystical-type experiences occasioned by psilocybin-containing mushrooms. The rated experiences occurred on average eight years before completion of the questionnaire. The current paper validates the MEQ30 using data from experimental studies with controlled doses of psilocybin. Data were pooled and analyzed from five laboratory experiments in which participants (n=184) received a moderate to high oral dose of psilocybin (at least 20 mg/70 kg). Results of confirmatory factor analysis demonstrate the reliability and internal validity of the MEQ30. Structural equation models demonstrate the external and convergent validity of the MEQ30 by showing that latent variable scores on the MEQ30 positively predict persisting change in attitudes, behavior, and well-being attributed to experiences with psilocybin while controlling for the contribution of the participant-rated intensity of drug effects. These findings support the use of the MEQ30 as an efficient measure of individual mystical experiences. A method to score a "complete mystical experience" that was used in previous versions of the mystical experience questionnaire is validated in the MEQ30, and a stand-alone version of the MEQ30 is provided for use in future research. © The Author(s) 2015.

  10. A statistical approach to selecting and confirming validation targets in -omics experiments

    PubMed Central

    2012-01-01

    Background Genomic technologies are, by their very nature, designed for hypothesis generation. In some cases, the hypotheses that are generated require that genome scientists confirm findings about specific genes or proteins. But one major advantage of high-throughput technology is that global genetic, genomic, transcriptomic, and proteomic behaviors can be observed. Manual confirmation of every statistically significant genomic result is prohibitively expensive. This has led researchers in genomics to adopt the strategy of confirming only a handful of the most statistically significant results, a small subset chosen for biological interest, or a small random subset. But there is no standard approach for selecting and quantitatively evaluating validation targets. Results Here we present a new statistical method and approach for statistically validating lists of significant results based on confirming only a small random sample. We apply our statistical method to show that the usual practice of confirming only the most statistically significant results does not statistically validate result lists. We analyze an extensively validated RNA-sequencing experiment to show that confirming a random subset can statistically validate entire lists of significant results. Finally, we analyze multiple publicly available microarray experiments to show that statistically validating random samples can both (i) provide evidence to confirm long gene lists and (ii) save thousands of dollars and hundreds of hours of labor over manual validation of each significant result. Conclusions For high-throughput -omics studies, statistical validation is a cost-effective and statistically valid approach to confirming lists of significant results. PMID:22738145

  11. Validation of the revised Mystical Experience Questionnaire in experimental sessions with psilocybin

    PubMed Central

    Barrett, Frederick S; Johnson, Matthew W; Griffiths, Roland R

    2016-01-01

    The 30-item revised Mystical Experience Questionnaire (MEQ30) was previously developed within an online survey of mystical-type experiences occasioned by psilocybin-containing mushrooms. The rated experiences occurred on average eight years before completion of the questionnaire. The current paper validates the MEQ30 using data from experimental studies with controlled doses of psilocybin. Data were pooled and analyzed from five laboratory experiments in which participants (n=184) received a moderate to high oral dose of psilocybin (at least 20 mg/70 kg). Results of confirmatory factor analysis demonstrate the reliability and internal validity of the MEQ30. Structural equation models demonstrate the external and convergent validity of the MEQ30 by showing that latent variable scores on the MEQ30 positively predict persisting change in attitudes, behavior, and well-being attributed to experiences with psilocybin while controlling for the contribution of the participant-rated intensity of drug effects. These findings support the use of the MEQ30 as an efficient measure of individual mystical experiences. A method to score a “complete mystical experience” that was used in previous versions of the mystical experience questionnaire is validated in the MEQ30, and a stand-alone version of the MEQ30 is provided for use in future research. PMID:26442957

  12. Electrolysis Performance Improvement and Validation Experiment

    NASA Technical Reports Server (NTRS)

    Schubert, Franz H.

    1992-01-01

    Viewgraphs on electrolysis performance improvement and validation experiment are presented. Topics covered include: water electrolysis: an ever increasing need/role for space missions; static feed electrolysis (SFE) technology: a concept developed for space applications; experiment objectives: why test in microgravity environment; and experiment description: approach, hardware description, test sequence and schedule.

  13. Results from SMAP Validation Experiments 2015 and 2016

    NASA Astrophysics Data System (ADS)

    Colliander, A.; Jackson, T. J.; Cosh, M. H.; Misra, S.; Crow, W.; Powers, J.; Wood, E. F.; Mohanty, B.; Judge, J.; Drewry, D.; McNairn, H.; Bullock, P.; Berg, A. A.; Magagi, R.; O'Neill, P. E.; Yueh, S. H.

    2017-12-01

    NASA's Soil Moisture Active Passive (SMAP) mission was launched in January 2015. The objective of the mission is global mapping of soil moisture and freeze/thaw state. Well-characterized sites with calibrated in situ soil moisture measurements are used to determine the quality of the soil moisture data products; these sites are designated as core validation sites (CVS). To support the CVS-based validation, airborne field experiments are used to provide high-fidelity validation data and to improve the SMAP retrieval algorithms. The SMAP project and NASA coordinated airborne field experiments at three CVS locations in 2015 and 2016. SMAP Validation Experiment 2015 (SMAPVEX15) was conducted around the Walnut Gulch CVS in Arizona in August, 2015. SMAPVEX16 was conducted at the South Fork CVS in Iowa and Carman CVS in Manitoba, Canada from May to August 2016. The airborne PALS (Passive Active L-band Sensor) instrument mapped all experiment areas several times resulting in 30 coincidental measurements with SMAP. The experiments included intensive ground sampling regime consisting of manual sampling and augmentation of the CVS soil moisture measurements with temporary networks of soil moisture sensors. Analyses using the data from these experiments have produced various results regarding the SMAP validation and related science questions. The SMAPVEX15 data set has been used for calibration of a hyper-resolution model for soil moisture product validation; development of a multi-scale parameterization approach for surface roughness, and validation of disaggregation of SMAP soil moisture with optical thermal signal. The SMAPVEX16 data set has been already used for studying the spatial upscaling within a pixel with highly heterogeneous soil texture distribution; for understanding the process of radiative transfer at plot scale in relation to field scale and SMAP footprint scale over highly heterogeneous vegetation distribution; for testing a data fusion based soil moisture

  14. PSI-Center Simulations of Validation Platform Experiments

    NASA Astrophysics Data System (ADS)

    Nelson, B. A.; Akcay, C.; Glasser, A. H.; Hansen, C. J.; Jarboe, T. R.; Marklin, G. J.; Milroy, R. D.; Morgan, K. D.; Norgaard, P. C.; Shumlak, U.; Victor, B. S.; Sovinec, C. R.; O'Bryan, J. B.; Held, E. D.; Ji, J.-Y.; Lukin, V. S.

    2013-10-01

    The Plasma Science and Innovation Center (PSI-Center - http://www.psicenter.org) supports collaborating validation platform experiments with extended MHD simulations. Collaborators include the Bellan Plasma Group (Caltech), CTH (Auburn U), FRX-L (Los Alamos National Laboratory), HIT-SI (U Wash - UW), LTX (PPPL), MAST (Culham), Pegasus (U Wisc-Madison), PHD/ELF (UW/MSNW), SSX (Swarthmore College), TCSU (UW), and ZaP/ZaP-HD (UW). Modifications have been made to the NIMROD, HiFi, and PSI-Tet codes to specifically model these experiments, including mesh generation/refinement, non-local closures, appropriate boundary conditions (external fields, insulating BCs, etc.), and kinetic and neutral particle interactions. The PSI-Center is exploring application of validation metrics between experimental data and simulations results. Biorthogonal decomposition is proving to be a powerful method to compare global temporal and spatial structures for validation. Results from these simulation and validation studies, as well as an overview of the PSI-Center status will be presented.

  15. Teaching "Instant Experience" with Graphical Model Validation Techniques

    ERIC Educational Resources Information Center

    Ekstrøm, Claus Thorn

    2014-01-01

    Graphical model validation techniques for linear normal models are often used to check the assumptions underlying a statistical model. We describe an approach to provide "instant experience" in looking at a graphical model validation plot, so it becomes easier to validate if any of the underlying assumptions are violated.

  16. Earth Radiation Budget Experiment (ERBE) validation

    NASA Technical Reports Server (NTRS)

    Barkstrom, Bruce R.; Harrison, Edwin F.; Smith, G. Louis; Green, Richard N.; Kibler, James F.; Cess, Robert D.

    1990-01-01

    During the past 4 years, data from the Earth Radiation Budget Experiment (ERBE) have been undergoing detailed examination. There is no direct source of groundtruth for the radiation budget. Thus, this validation effort has had to rely heavily upon intercomparisons between different types of measurements. The ERBE SCIENCE Team chose 10 measures of agreement as validation criteria. Late in August 1988, the Team agreed that the data met these conditions. As a result, the final, monthly averaged data products are being archived. These products, their validation, and some results for January 1986 are described. Information is provided on obtaining the data from the archive.

  17. Initial Retrieval Validation from the Joint Airborne IASI Validation Experiment (JAIVEx)

    NASA Technical Reports Server (NTRS)

    Zhou, Daniel K.; Liu, Xu; Smith, WIlliam L.; Larar, Allen M.; Taylor, Jonathan P.; Revercomb, Henry E.; Mango, Stephen A.; Schluessel, Peter; Calbet, Xavier

    2007-01-01

    The Joint Airborne IASI Validation Experiment (JAIVEx) was conducted during April 2007 mainly for validation of the Infrared Atmospheric Sounding Interferometer (IASI) on the MetOp satellite, but also included a strong component focusing on validation of the Atmospheric InfraRed Sounder (AIRS) aboard the AQUA satellite. The cross validation of IASI and AIRS is important for the joint use of their data in the global Numerical Weather Prediction process. Initial inter-comparisons of geophysical products have been conducted from different aspects, such as using different measurements from airborne ultraspectral Fourier transform spectrometers (specifically, the NPOESS Airborne Sounder Testbed Interferometer (NAST-I) and the Scanning-High resolution Interferometer Sounder (S-HIS) aboard the NASA WB-57 aircraft), UK Facility for Airborne Atmospheric Measurements (FAAM) BAe146-301 aircraft insitu instruments, dedicated dropsondes, radiosondes, and ground based Raman Lidar. An overview of the JAIVEx retrieval validation plan and some initial results of this field campaign are presented.

  18. CFD validation experiments at the Lockheed-Georgia Company

    NASA Technical Reports Server (NTRS)

    Malone, John B.; Thomas, Andrew S. W.

    1987-01-01

    Information is given in viewgraph form on computational fluid dynamics (CFD) validation experiments at the Lockheed-Georgia Company. Topics covered include validation experiments on a generic fighter configuration, a transport configuration, and a generic hypersonic vehicle configuration; computational procedures; surface and pressure measurements on wings; laser velocimeter measurements of a multi-element airfoil system; the flowfield around a stiffened airfoil; laser velocimeter surveys of a circulation control wing; circulation control for high lift; and high angle of attack aerodynamic evaluations.

  19. EAQUATE: An International Experiment for Hyper-Spectral Atmospheric Sounding Validation

    NASA Technical Reports Server (NTRS)

    Taylor, J. P.; Smith, W.; Cuomo, V.; Larar, A.; Zhou, D.; Serio, C.; Maestri, T.; Rizzi, R.; Newman, S.; Antonelli, P.; hide

    2008-01-01

    The international experiment called EAQUATE (European AQUA Thermodynamic Experiment) was held in September 2004 in Italy and the United Kingdom to demonstrate certain ground-based and airborne systems useful for validating hyperspectral satellite sounding observations. A range of flights over land and marine surfaces were conducted to coincide with overpasses of the AIRS instrument on the EOS Aqua platform. Direct radiance evaluation of AIRS using NAST-I and SHIS has shown excellent agreement. Comparisons of level 2 retrievals of temperature and water vapor from AIRS and NAST-I validated against high quality lidar and drop sonde data show that the 1K/1km and 10%/1km requirements for temperature and water vapor (respectively) are generally being met. The EAQUATE campaign has proven the need for synergistic measurements from a range of observing systems for satellite cal/val and has paved the way for future cal/val activities in support of IASI on the European Metop platform and CrIS on the US NPP/NPOESS platform.

  20. Validation and scaling of soil moisture in a semi-arid environment: SMAP Validation Experiment 2015 (SMAPVEX15)

    USDA-ARS?s Scientific Manuscript database

    The NASA SMAP (Soil Moisture Active Passive) mission conducted the SMAP Validation Experiment 2015 (SMAPVEX15) in order to support the calibration and validation activities of SMAP soil moisture data product.The main goals of the experiment were to address issues regarding the spatial disaggregation...

  1. SATS HVO Concept Validation Experiment

    NASA Technical Reports Server (NTRS)

    Consiglio, Maria; Williams, Daniel; Murdoch, Jennifer; Adams, Catherine

    2005-01-01

    A human-in-the-loop simulation experiment was conducted at the NASA Langley Research Center s (LaRC) Air Traffic Operations Lab (ATOL) in an effort to comprehensively validate tools and procedures intended to enable the Small Aircraft Transportation System, Higher Volume Operations (SATS HVO) concept of operations. The SATS HVO procedures were developed to increase the rate of operations at non-towered, non-radar airports in near all-weather conditions. A key element of the design is the establishment of a volume of airspace around designated airports where pilots accept responsibility for self-separation. Flights operating at these airports, are given approach sequencing information computed by a ground based automated system. The SATS HVO validation experiment was conducted in the ATOL during the spring of 2004 in order to determine if a pilot can safely and proficiently fly an airplane while performing SATS HVO procedures. Comparative measures of flight path error, perceived workload and situation awareness were obtained for two types of scenarios. Baseline scenarios were representative of today s system utilizing procedure separation, where air traffic control grants one approach or departure clearance at a time. SATS HVO scenarios represented approaches and departure procedures as described in the SATS HVO concept of operations. Results from the experiment indicate that low time pilots were able to fly SATS HVO procedures and maintain self-separation as safely and proficiently as flying today's procedures.

  2. The Play Experience Scale: development and validation of a measure of play.

    PubMed

    Pavlas, Davin; Jentsch, Florian; Salas, Eduardo; Fiore, Stephen M; Sims, Valerie

    2012-04-01

    A measure of play experience in video games was developed through literature review and two empirical validation studies. Despite the considerable attention given to games in the behavioral sciences, play experience remains empirically underexamined. One reason for this gap is the absence of a scale that measures play experience. In Study 1, the initial Play Experience Scale (PES) was tested through an online validation that featured three different games (N = 203). In Study 2, a revised PES was assessed with a serious game in the laboratory (N = 77). Through principal component analysis of the Study 1 data, the initial 20-item PES was revised, resulting in the 16-item PES-16. Study 2 showed the PES-16 to be a robust instrument with the same patterns of correlations as in Study 1 via (a) internal consistency estimates, (b) correlations with established scales of motivation, (c) distributions of PES-16 scores in different game conditions, and (d) examination of the average variance extracted of the PES and the Intrinsic Motivation Scale. We suggest that the PES is appropriate for use in further validation studies. Additional examinations of the scale are required to determine its applicability to other contexts and its relationship with other constructs. The PES is potentially relevant to human factors undertakings involving video games, including basic research into play, games, and learning; prototype testing; and exploratory learning studies.

  3. Changes and Issues in the Validation of Experience

    ERIC Educational Resources Information Center

    Triby, Emmanuel

    2005-01-01

    This article analyses the main changes in the rules for validating experience in France and of what they mean for society. It goes on to consider university validation practices. The way in which this system is evolving offers a chance to identify the issues involved for the economy and for society, with particular attention to the expected…

  4. Bayesian cross-entropy methodology for optimal design of validation experiments

    NASA Astrophysics Data System (ADS)

    Jiang, X.; Mahadevan, S.

    2006-07-01

    An important concern in the design of validation experiments is how to incorporate the mathematical model in the design in order to allow conclusive comparisons of model prediction with experimental output in model assessment. The classical experimental design methods are more suitable for phenomena discovery and may result in a subjective, expensive, time-consuming and ineffective design that may adversely impact these comparisons. In this paper, an integrated Bayesian cross-entropy methodology is proposed to perform the optimal design of validation experiments incorporating the computational model. The expected cross entropy, an information-theoretic distance between the distributions of model prediction and experimental observation, is defined as a utility function to measure the similarity of two distributions. A simulated annealing algorithm is used to find optimal values of input variables through minimizing or maximizing the expected cross entropy. The measured data after testing with the optimum input values are used to update the distribution of the experimental output using Bayes theorem. The procedure is repeated to adaptively design the required number of experiments for model assessment, each time ensuring that the experiment provides effective comparison for validation. The methodology is illustrated for the optimal design of validation experiments for a three-leg bolted joint structure and a composite helicopter rotor hub component.

  5. Reliability and validity of the neurorehabilitation experience questionnaire for inpatients.

    PubMed

    Kneebone, Ian I; Hull, Samantha L; McGurk, Rhona; Cropley, Mark

    2012-09-01

    Patient-centered measures of the inpatient neurorehabilitation experience are needed to assess services. The objective of this study was to develop a valid and reliable Neurorehabilitation Experience Questionnaire (NREQ) to assess whether neurorehabilitation inpatients experience service elements important to them. Based on the themes established in prior qualitative research, adopting questions from established inventories and using a literature review, a draft version of the NREQ was generated. Focus groups and interviews were conducted with 9 patients and 26 staff from neurological rehabilitation units to establish face validity. Then, 70 patients were recruited to complete the NREQ to ascertain reliability (internal and test-retest) and concurrent validity. On the basis of the face validity testing, several modifications were made to the draft version of the NREQ. Subsequently, internal reliability (time 1 α = .76, time 2 α = .80), test retest reliability (r = 0.70), and concurrent validity (r = 0.32 and r = 0.56) were established for the revised version. Whereas responses were associated with positive mood (r = 0.30), they appeared not to be influenced by negative mood, age, education, length of stay, sex, functional independence, or whether a participant had been a patient on a unit previously. Preliminary validation of the NREQ suggests promise for use with its target population.

  6. Latency-Based and Psychophysiological Measures of Sexual Interest Show Convergent and Concurrent Validity.

    PubMed

    Ó Ciardha, Caoilte; Attard-Johnson, Janice; Bindemann, Markus

    2018-04-01

    Latency-based measures of sexual interest require additional evidence of validity, as do newer pupil dilation approaches. A total of 102 community men completed six latency-based measures of sexual interest. Pupillary responses were recorded during three of these tasks and in an additional task where no participant response was required. For adult stimuli, there was a high degree of intercorrelation between measures, suggesting that tasks may be measuring the same underlying construct (convergent validity). In addition to being correlated with one another, measures also predicted participants' self-reported sexual interest, demonstrating concurrent validity (i.e., the ability of a task to predict a more validated, simultaneously recorded, measure). Latency-based and pupillometric approaches also showed preliminary evidence of concurrent validity in predicting both self-reported interest in child molestation and viewing pornographic material containing children. Taken together, the study findings build on the evidence base for the validity of latency-based and pupillometric measures of sexual interest.

  7. Radiative transfer model validations during the First ISLSCP Field Experiment

    NASA Technical Reports Server (NTRS)

    Frouin, Robert; Breon, Francois-Marie; Gautier, Catherine

    1990-01-01

    Two simple radiative transfer models, the 5S model based on Tanre et al. (1985, 1986) and the wide-band model of Morcrette (1984) are validated by comparing their outputs with results obtained during the First ISLSCP Field Experiment on concomitant radiosonde, aerosol turbidity, and radiation measurements and sky photographs. Results showed that the 5S model overestimates the short-wave irradiance by 13.2 W/sq m, whereas the Morcrette model underestimated the long-wave irradiance by 7.4 W/sq m.

  8. Methodology for turbulence code validation: Quantification of simulation-experiment agreement and application to the TORPEX experiment

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Ricci, Paolo; Theiler, C.; Fasoli, A.

    A methodology for plasma turbulence code validation is discussed, focusing on quantitative assessment of the agreement between experiments and simulations. The present work extends the analysis carried out in a previous paper [P. Ricci et al., Phys. Plasmas 16, 055703 (2009)] where the validation observables were introduced. Here, it is discussed how to quantify the agreement between experiments and simulations with respect to each observable, how to define a metric to evaluate this agreement globally, and - finally - how to assess the quality of a validation procedure. The methodology is then applied to the simulation of the basic plasmamore » physics experiment TORPEX [A. Fasoli et al., Phys. Plasmas 13, 055902 (2006)], considering both two-dimensional and three-dimensional simulation models.« less

  9. The Grand Banks ERS-1 SAR wave spectra validation experiment

    NASA Technical Reports Server (NTRS)

    Vachon, P. W.; Dobson, F. W.; Smith, S. D.; Anderson, R. J.; Buckley, J. R.; Allingham, M.; Vandemark, D.; Walsh, E. J.; Khandekar, M.; Lalbeharry, R.

    1993-01-01

    As part of the ERS-1 validation program, the ERS-1 Synthetic Aperture Radar (SAR) wave spectra validation experiment was carried out over the Grand Banks of Newfoundland (Canada) in Nov. 1991. The principal objective of the experiment was to obtain complete sets of wind and wave data from a variety of calibrated instruments to validate SAR measurements of ocean wave spectra. The field program activities are described and the rather complex wind and wave conditions which were observed are summarized. Spectral comparisons with ERS-1 SAR image spectra are provided. The ERS-1 SAR is shown to have measured swell and range traveling wind seas, but did not measure azimuth traveling wind seas at any time during the experiment. Results of velocity bunching forward mapping and new measurements of the relationship between wind stress and sea state are also shown.

  10. Reconceptualising the external validity of discrete choice experiments.

    PubMed

    Lancsar, Emily; Swait, Joffre

    2014-10-01

    External validity is a crucial but under-researched topic when considering using discrete choice experiment (DCE) results to inform decision making in clinical, commercial or policy contexts. We present the theory and tests traditionally used to explore external validity that focus on a comparison of final outcomes and review how this traditional definition has been empirically tested in health economics and other sectors (such as transport, environment and marketing) in which DCE methods are applied. While an important component, we argue that the investigation of external validity should be much broader than a comparison of final outcomes. In doing so, we introduce a new and more comprehensive conceptualisation of external validity, closely linked to process validity, that moves us from the simple characterisation of a model as being or not being externally valid on the basis of predictive performance, to the concept that external validity should be an objective pursued from the initial conceptualisation and design of any DCE. We discuss how such a broader definition of external validity can be fruitfully used and suggest innovative ways in which it can be explored in practice.

  11. Prognostics of Power Electronics, Methods and Validation Experiments

    NASA Technical Reports Server (NTRS)

    Kulkarni, Chetan S.; Celaya, Jose R.; Biswas, Gautam; Goebel, Kai

    2012-01-01

    Abstract Failure of electronic devices is a concern for future electric aircrafts that will see an increase of electronics to drive and control safety-critical equipment throughout the aircraft. As a result, investigation of precursors to failure in electronics and prediction of remaining life of electronic components is of key importance. DC-DC power converters are power electronics systems employed typically as sourcing elements for avionics equipment. Current research efforts in prognostics for these power systems focuses on the identification of failure mechanisms and the development of accelerated aging methodologies and systems to accelerate the aging process of test devices, while continuously measuring key electrical and thermal parameters. Preliminary model-based prognostics algorithms have been developed making use of empirical degradation models and physics-inspired degradation model with focus on key components like electrolytic capacitors and power MOSFETs (metal-oxide-semiconductor-field-effect-transistor). This paper presents current results on the development of validation methods for prognostics algorithms of power electrolytic capacitors. Particularly, in the use of accelerated aging systems for algorithm validation. Validation of prognostics algorithms present difficulties in practice due to the lack of run-to-failure experiments in deployed systems. By using accelerated experiments, we circumvent this problem in order to define initial validation activities.

  12. Validation Experiences and Persistence among Urban Community College Students

    ERIC Educational Resources Information Center

    Barnett, Elisabeth A.

    2007-01-01

    The purpose of this research was to examine the extent to which urban community college students' experiences with validation by faculty contributed to their sense of integration in college and whether this, in turn, contributed to their intent to persist in college. This study focused on urban community college students' validating experiences…

  13. CFD validation experiments at McDonnell Aircraft Company

    NASA Technical Reports Server (NTRS)

    Verhoff, August

    1987-01-01

    Information is given in viewgraph form on computational fluid dynamics (CFD) validation experiments at McDonnell Aircraft Company. Topics covered include a high speed research model, a supersonic persistence fighter model, a generic fighter wing model, surface grids, force and moment predictions, surface pressure predictions, forebody models with 65 degree clipped delta wings, and the low aspect ratio wing/body experiment.

  14. Experience with Aero- and Fluid-Dynamic Testing for Engineering and CFD Validation

    NASA Technical Reports Server (NTRS)

    Ross, James C.

    2016-01-01

    Ever since computations have been used to simulate aerodynamics the need to ensure that the computations adequately represent real life has followed. Many experiments have been performed specifically for validation and as computational methods have improved, so have the validation experiments. Validation is also a moving target because computational methods improve requiring validation for the new aspect of flow physics that the computations aim to capture. Concurrently, new measurement techniques are being developed that can help capture more detailed flow features pressure sensitive paint (PSP) and particle image velocimetry (PIV) come to mind. This paper will present various wind-tunnel tests the author has been involved with and how they were used for validation of various kinds of CFD. A particular focus is the application of advanced measurement techniques to flow fields (and geometries) that had proven to be difficult to predict computationally. Many of these difficult flow problems arose from engineering and development problems that needed to be solved for a particular vehicle or research program. In some cases the experiments required to solve the engineering problems were refined to provide valuable CFD validation data in addition to the primary engineering data. All of these experiments have provided physical insight and validation data for a wide range of aerodynamic and acoustic phenomena for vehicles ranging from tractor-trailers to crewed spacecraft.

  15. Validation Experiments for Spent-Fuel Dry-Cask In-Basket Convection

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Smith, Barton L.

    2016-08-16

    This work consisted of the following major efforts; 1. Literature survey on validation of external natural convection; 2. Design the experiment; 3. Build the experiment; 4. Run the experiment; 5. Collect results; 6. Disseminate results; and 7. Perform a CFD validation study using the results. We note that while all tasks are complete, some deviations from the original plan were made. Specifically, geometrical changes in the parameter space were skipped in favor of flow condition changes, which were found to be much more practical to implement. Changing the geometry required new as-built measurements, which proved extremely costly and impractical givenmore » the time and funds available« less

  16. Validation results of satellite mock-up capturing experiment using nets

    NASA Astrophysics Data System (ADS)

    Medina, Alberto; Cercós, Lorenzo; Stefanescu, Raluca M.; Benvenuto, Riccardo; Pesce, Vincenzo; Marcon, Marco; Lavagna, Michèle; González, Iván; Rodríguez López, Nuria; Wormnes, Kjetil

    2017-05-01

    The PATENDER activity (Net parametric characterization and parabolic flight), funded by the European Space Agency (ESA) via its Clean Space initiative, was aiming to validate a simulation tool for designing nets for capturing space debris. This validation has been performed through a set of different experiments under microgravity conditions where a net was launched capturing and wrapping a satellite mock-up. This paper presents the architecture of the thrown-net dynamics simulator together with the set-up of the deployment experiment and its trajectory reconstruction results on a parabolic flight (Novespace A-310, June 2015). The simulator has been implemented within the Blender framework in order to provide a highly configurable tool, able to reproduce different scenarios for Active Debris Removal missions. The experiment has been performed over thirty parabolas offering around 22 s of zero-g conditions. Flexible meshed fabric structure (the net) ejected from a container and propelled by corner masses (the bullets) arranged around its circumference have been launched at different initial velocities and launching angles using a pneumatic-based dedicated mechanism (representing the chaser satellite) against a target mock-up (the target satellite). High-speed motion cameras were recording the experiment allowing 3D reconstruction of the net motion. The net knots have been coloured to allow the images post-process using colour segmentation, stereo matching and iterative closest point (ICP) for knots tracking. The final objective of the activity was the validation of the net deployment and wrapping simulator using images recorded during the parabolic flight. The high-resolution images acquired have been post-processed to determine accurately the initial conditions and generate the reference data (position and velocity of all knots of the net along its deployment and wrapping of the target mock-up) for the simulator validation. The simulator has been properly

  17. CFD Modeling Needs and What Makes a Good Supersonic Combustion Validation Experiment

    NASA Technical Reports Server (NTRS)

    Gaffney, Richard L., Jr.; Cutler, Andrew D.

    2005-01-01

    If a CFD code/model developer is asked what experimental data he wants to validate his code or numerical model, his answer will be: "Everything, everywhere, at all times." Since this is not possible, practical, or even reasonable, the developer must understand what can be measured within the limits imposed by the test article, the test location, the test environment and the available diagnostic equipment. At the same time, it is important for the expermentalist/diagnostician to understand what the CFD developer needs (as opposed to wants) in order to conduct a useful CFD validation experiment. If these needs are not known, it is possible to neglect easily measured quantities at locations needed by the developer, rendering the data set useless for validation purposes. It is also important for the experimentalist/diagnostician to understand what the developer is trying to validate so that the experiment can be designed to isolate (as much as possible) the effects of a particular physical phenomena that is associated with the model to be validated. The probability of a successful validation experiment can be greatly increased if the two groups work together, each understanding the needs and limitations of the other.

  18. DC-8 and ER-2 in Sweden for the Sage III Ozone Loss and Validation Experiment (SOLVE)

    NASA Technical Reports Server (NTRS)

    2000-01-01

    This 48 second video shows Dryden's Airborne Science aircraft in Kiruna Sweden in January 2000. The DC-8 and ER-2 conducted atmospheric studies for the Sage III Ozone Loss and Validation Experiment (SOLVE).

  19. Validation Experiences and Persistence among Community College Students

    ERIC Educational Resources Information Center

    Barnett, Elisabeth A.

    2011-01-01

    The purpose of this correlational research was to examine the extent to which community college students' experiences with validation by faculty (Rendon, 1994, 2002) predicted: (a) their sense of integration, and (b) their intent to persist. The research was designed as an elaboration of constructs within Tinto's (1993) Longitudinal Model of…

  20. SeaSat-A Satellite Scatterometer (SASS) Validation and Experiment Plan

    NASA Technical Reports Server (NTRS)

    Schroeder, L. C. (Editor)

    1978-01-01

    This plan was generated by the SeaSat-A satellite scatterometer experiment team to define the pre-and post-launch activities necessary to conduct sensor validation and geophysical evaluation. Details included are an instrument and experiment description/performance requirements, success criteria, constraints, mission requirements, data processing requirement and data analysis responsibilities.

  1. Development and validation of the Consumer Quality index instrument to measure the experience and priority of chronic dialysis patients.

    PubMed

    van der Veer, Sabine N; Jager, Kitty J; Visserman, Ella; Beekman, Robert J; Boeschoten, Els W; de Keizer, Nicolette F; Heuveling, Lara; Stronks, Karien; Arah, Onyebuchi A

    2012-08-01

    Patient experience is an established indicator of quality of care. Validated tools that measure both experiences and priorities are lacking for chronic dialysis care, hampering identification of negative experiences that patients actually rate important. We developed two Consumer Quality (CQ) index questionnaires, one for in-centre haemodialysis (CHD) and the other for peritoneal dialysis and home haemodialysis (PHHD) care. The instruments were validated using exploratory factor analyses, reliability analysis of identified scales and assessing the association between reliable scales and global ratings. We investigated opportunities for improvement by combining suboptimal experience with patient priority. Sixteen dialysis centres participated in our study. The pilot CQ index for CHD care consisted of 71 questions. Based on data of 592 respondents, we identified 42 core experience items in 10 scales with Cronbach's α ranging from 0.38 to 0.88; five were reliable (α ≥ 0.70). The instrument identified information on centres' fire procedures as the aspect of care exhibiting the biggest opportunity for improvement. The pilot CQ index PHHD comprised 56 questions. The response of 248 patients yielded 31 core experience items in nine scales with Cronbach's α ranging between 0.53 and 0.85; six were reliable. Information on kidney transplantation during pre-dialysis showed most room for improvement. However, for both types of care, opportunities for improvement were mostly limited. The CQ index reliably and validly captures dialysis patient experience. Overall, most care aspects showed limited room for improvement, mainly because patients participating in our study rated their experience to be optimal. To evaluate items with high priority, but with which relatively few patients have experience, more qualitative instruments should be considered.

  2. Chemometric and biological validation of a capillary electrophoresis metabolomic experiment of Schistosoma mansoni infection in mice.

    PubMed

    Garcia-Perez, Isabel; Angulo, Santiago; Utzinger, Jürg; Holmes, Elaine; Legido-Quigley, Cristina; Barbas, Coral

    2010-07-01

    Metabonomic and metabolomic studies are increasingly utilized for biomarker identification in different fields, including biology of infection. The confluence of improved analytical platforms and the availability of powerful multivariate analysis software have rendered the multiparameter profiles generated by these omics platforms a user-friendly alternative to the established analysis methods where the quality and practice of a procedure is well defined. However, unlike traditional assays, validation methods for these new multivariate profiling tools have yet to be established. We propose a validation for models obtained by CE fingerprinting of urine from mice infected with the blood fluke Schistosoma mansoni. We have analysed urine samples from two sets of mice infected in an inter-laboratory experiment where different infection methods and animal husbandry procedures were employed in order to establish the core biological response to a S. mansoni infection. CE data were analysed using principal component analysis. Validation of the scores consisted of permutation scrambling (100 repetitions) and a manual validation method, using a third of the samples (not included in the model) as a test or prediction set. The validation yielded 100% specificity and 100% sensitivity, demonstrating the robustness of these models with respect to deciphering metabolic perturbations in the mouse due to a S. mansoni infection. A total of 20 metabolites across the two experiments were identified that significantly discriminated between S. mansoni-infected and noninfected control samples. Only one of these metabolites, allantoin, was identified as manifesting different behaviour in the two experiments. This study shows the reproducibility of CE-based metabolic profiling methods for disease characterization and screening and highlights the importance of much needed validation strategies in the emerging field of metabolomics.

  3. Digital Fly-By-Wire Flight Control Validation Experience

    NASA Technical Reports Server (NTRS)

    Szalai, K. J.; Jarvis, C. R.; Krier, G. E.; Megna, V. A.; Brock, L. D.; Odonnell, R. N.

    1978-01-01

    The experience gained in digital fly-by-wire technology through a flight test program being conducted by the NASA Dryden Flight Research Center in an F-8C aircraft is described. The system requirements are outlined, along with the requirements for flight qualification. The system is described, including the hardware components, the aircraft installation, and the system operation. The flight qualification experience is emphasized. The qualification process included the theoretical validation of the basic design, laboratory testing of the hardware and software elements, systems level testing, and flight testing. The most productive testing was performed on an iron bird aircraft, which used the actual electronic and hydraulic hardware and a simulation of the F-8 characteristics to provide the flight environment. The iron bird was used for sensor and system redundancy management testing, failure modes and effects testing, and stress testing in many cases with the pilot in the loop. The flight test program confirmed the quality of the validation process by achieving 50 flights without a known undetected failure and with no false alarms.

  4. Disruption Tolerant Networking Flight Validation Experiment on NASA's EPOXI Mission

    NASA Technical Reports Server (NTRS)

    Wyatt, Jay; Burleigh, Scott; Jones, Ross; Torgerson, Leigh; Wissler, Steve

    2009-01-01

    In October and November of 2008, the Jet Propulsion Laboratory installed and tested essential elements of Delay/Disruption Tolerant Networking (DTN) technology on the Deep Impact spacecraft. This experiment, called Deep Impact Network Experiment (DINET), was performed in close cooperation with the EPOXI project which has responsibility for the spacecraft. During DINET some 300 images were transmitted from the JPL nodes to the spacecraft. Then they were automatically forwarded from the spacecraft back to the JPL nodes, exercising DTN's bundle origination, transmission, acquisition, dynamic route computation, congestion control, prioritization, custody transfer, and automatic retransmission procedures, both on the spacecraft and on the ground, over a period of 27 days. All transmitted bundles were successfully received, without corruption. The DINET experiment demonstrated DTN readiness for operational use in space missions. This activity was part of a larger NASA space DTN development program to mature DTN to flight readiness for a wide variety of mission types by the end of 2011. This paper describes the DTN protocols, the flight demo implementation, validation metrics which were created for the experiment, and validation results.

  5. Development and Validation of a Scale Assessing Mental Health Clinicians' Experiences of Associative Stigma.

    PubMed

    Yanos, Philip T; Vayshenker, Beth; DeLuca, Joseph S; O'Connor, Lauren K

    2017-10-01

    Mental health professionals who work with people with serious mental illnesses are believed to experience associative stigma. Evidence suggests that associative stigma could play an important role in the erosion of empathy among professionals; however, no validated measure of the construct currently exists. This study examined the convergent and discriminant validity and factor structure of a new scale assessing the associative stigma experiences of clinicians working with people with serious mental illnesses. A total of 473 clinicians were recruited from professional associations in the United States and participated in an online study. Participants completed the Clinician Associative Stigma Scale (CASS) and measures of burnout, quality of care, expectations about recovery, and self-efficacy. Associative stigma experiences were commonly endorsed; eight items on the 18-item scale were endorsed as being experienced "sometimes" or "often" by over 50% of the sample. The new measure demonstrated a logical four-factor structure: "negative stereotypes about professional effectiveness," "discomfort with disclosure," "negative stereotypes about people with mental illness," and "stereotypes about professionals' mental health." The measure had good internal consistency. It was significantly related to measures of burnout and quality of care, but it was not related to measures of self-efficacy or expectations about recovery. Findings suggest that the CASS is internally consistent and shows evidence of convergent validity and that associative stigma is commonly experienced by mental health professionals who work with people with serious mental illnesses.

  6. Validation of the Turkish Version of the Sexual Health Outcomes in Women Questionnaire (SHOW-Q) in Turkish-Speaking Women.

    PubMed

    Selcuk, Selcuk; Kucukbas, Mehmet; Cam, Cetin; Eser, Ahmet; Devranoglu, Belgin; Turkyilmaz, Sebnem; Karateke, Ates

    2016-06-01

    The Sexual Health Outcomes in Women Questionnaire (SHOW-Q) is designed to evaluate the sexual life of women for satisfaction, orgasm, desire, and pelvic problem interference. The SHOW-Q is important for evaluating worsening of sexual life for patients with pelvic problems and the management of these women to improve their sexual life. To validate the Turkish versions of the SHOW-Q for Turkish-speaking women. The Turkish version of the SHOW-Q was generated by two independent professional English-to-Turkish translators. The translated version of the SHOW-Q was reverse translated by two bilingual translators whose native language was English. Women with at least one symptom related to pelvic problems (n = 71) and those with no symptoms (n = 38) were included in the present study. Test-retest reliability analysis, content-face validity, internal consistency reliability, item-total correlations, convergent validity, construct validity, and factorial validity were performed to assess the psychometric properties of the Turkish versions of the SHOW-Q. Test-retest reliability demonstrated good correlation for all subscales. Cronbach α values ranged from 0.735 to 0.892 and indicated high internal consistency. There was a strong correlation for the corresponding subscales between the SHOW-Q and the Female Sexual Function Index. The mean score of each SHOW-Q subscale showed significant differences between symptomatic and asymptomatic patients. The Turkish version of the SHOW-Q is a valid and reliable instrument that can be used to evaluate the sexual life of Turkish-speaking women with different pelvic problems. Copyright © 2016 The Authors. Published by Elsevier Inc. All rights reserved.

  7. Validation of Skills, Knowledge and Experience in Lifelong Learning in Europe

    ERIC Educational Resources Information Center

    Ogunleye, James

    2012-01-01

    The paper examines systems of validation of skills and experience as well as the main methods/tools currently used for validating skills and knowledge in lifelong learning. The paper uses mixed methods--a case study research and content analysis of European Union policy documents and frameworks--as a basis for this research. The selection of the…

  8. Progress Towards a Microgravity CFD Validation Study Using the ISS SPHERES-SLOSH Experiment

    NASA Technical Reports Server (NTRS)

    Storey, Jedediah M.; Kirk, Daniel; Marsell, Brandon (Editor); Schallhorn, Paul (Editor)

    2017-01-01

    Understanding, predicting, and controlling fluid slosh dynamics is critical to safety and improving performance of space missions when a significant percentage of the spacecrafts mass is a liquid. Computational fluid dynamics simulations can be used to predict the dynamics of slosh, but these programs require extensive validation. Many CFD programs have been validated by slosh experiments using various fluids in earth gravity, but prior to the ISS SPHERES-Slosh experiment1, little experimental data for long-duration, zero-gravity slosh existed. This paper presents the current status of an ongoing CFD validation study using the ISS SPHERES-Slosh experimental data.

  9. Progress Towards a Microgravity CFD Validation Study Using the ISS SPHERES-SLOSH Experiment

    NASA Technical Reports Server (NTRS)

    Storey, Jed; Kirk, Daniel (Editor); Marsell, Brandon (Editor); Schallhorn, Paul (Editor)

    2017-01-01

    Understanding, predicting, and controlling fluid slosh dynamics is critical to safety and improving performance of space missions when a significant percentage of the spacecrafts mass is a liquid. Computational fluid dynamics simulations can be used to predict the dynamics of slosh, but these programs require extensive validation. Many CFD programs have been validated by slosh experiments using various fluids in earth gravity, but prior to the ISS SPHERES-Slosh experiment, little experimental data for long-duration, zero-gravity slosh existed. This paper presents the current status of an ongoing CFD validation study using the ISS SPHERES-Slosh experimental data.

  10. The risk of bias in systematic reviews tool showed fair reliability and good construct validity.

    PubMed

    Bühn, Stefanie; Mathes, Tim; Prengel, Peggy; Wegewitz, Uta; Ostermann, Thomas; Robens, Sibylle; Pieper, Dawid

    2017-11-01

    There is a movement from generic quality checklists toward a more domain-based approach in critical appraisal tools. This study aimed to report on a first experience with the newly developed risk of bias in systematic reviews (ROBIS) tool and compare it with A Measurement Tool to Assess Systematic Reviews (AMSTAR), that is, the most common used tool to assess methodological quality of systematic reviews while assessing validity, reliability, and applicability. Validation study with four reviewers based on 16 systematic reviews in the field of occupational health. Interrater reliability (IRR) of all four raters was highest for domain 2 (Fleiss' kappa κ = 0.56) and lowest for domain 4 (κ = 0.04). For ROBIS, median IRR was κ = 0.52 (range 0.13-0.88) for the experienced pair of raters compared to κ = 0.32 (range 0.12-0.76) for the less experienced pair of raters. The percentage of "yes" scores of each review of ROBIS ratings was strongly correlated with the AMSTAR ratings (r s  = 0.76; P = 0.01). ROBIS has fair reliability and good construct validity to assess the risk of bias in systematic reviews. More validation studies are needed to investigate reliability and applicability, in particular. Copyright © 2017 Elsevier Inc. All rights reserved.

  11. Validity And Practicality of Experiment Integrated Guided Inquiry-Based Module on Topic of Colloidal Chemistry for Senior High School Learning

    NASA Astrophysics Data System (ADS)

    Andromeda, A.; Lufri; Festiyed; Ellizar, E.; Iryani, I.; Guspatni, G.; Fitri, L.

    2018-04-01

    This Research & Development study aims to produce a valid and practical experiment integrated guided inquiry based module on topic of colloidal chemistry. 4D instructional design model was selected in this study. Limited trial of the product was conducted at SMAN 7 Padang. Instruments used were validity and practicality questionnaires. Validity and practicality data were analyzed using Kappa moment. Analysis of the data shows that Kappa moment for validity was 0.88 indicating a very high degree of validity. Kappa moments for the practicality from students and teachers were 0.89 and 0.95 respectively indicating high degree of practicality. Analysis on the module filled in by students shows that 91.37% students could correctly answer critical thinking, exercise, prelab, postlab and worksheet questions asked in the module. These findings indicate that the integrated guided inquiry based module on topic of colloidal chemistry was valid and practical for chemistry learning in senior high school.

  12. Pathways to Engineering: The Validation Experiences of Transfer Students

    ERIC Educational Resources Information Center

    Zhang, Yi; Ozuna, Taryn

    2015-01-01

    Community college engineering transfer students are a critical student population of engineering degree recipients and technical workforce in the United States. Focusing on this group of students, we adopted Rendón's (1994) validation theory to explore the students' experiences in community colleges prior to transferring to a four-year…

  13. Construction and Initial Validation of the Multiracial Experiences Measure (MEM)

    PubMed Central

    Yoo, Hyung Chol; Jackson, Kelly; Guevarra, Rudy P.; Miller, Matthew J.; Harrington, Blair

    2015-01-01

    This article describes the development and validation of the Multiracial Experiences Measure (MEM): a new measure that assesses uniquely racialized risks and resiliencies experienced by individuals of mixed racial heritage. Across two studies, there was evidence for the validation of the 25-item MEM with 5 subscales including Shifting Expressions, Perceived Racial Ambiguity, Creating Third Space, Multicultural Engagement, and Multiracial Discrimination. The 5-subscale structure of the MEM was supported by a combination of exploratory and confirmatory factor analyses. Evidence of criterion-related validity was partially supported with MEM subscales correlating with measures of racial diversity in one’s social network, color-blind racial attitude, psychological distress, and identity conflict. Evidence of discriminant validity was supported with MEM subscales not correlating with impression management. Implications for future research and suggestions for utilization of the MEM in clinical practice with multiracial adults are discussed. PMID:26460977

  14. Construction and initial validation of the Multiracial Experiences Measure (MEM).

    PubMed

    Yoo, Hyung Chol; Jackson, Kelly F; Guevarra, Rudy P; Miller, Matthew J; Harrington, Blair

    2016-03-01

    This article describes the development and validation of the Multiracial Experiences Measure (MEM): a new measure that assesses uniquely racialized risks and resiliencies experienced by individuals of mixed racial heritage. Across 2 studies, there was evidence for the validation of the 25-item MEM with 5 subscales including Shifting Expressions, Perceived Racial Ambiguity, Creating Third Space, Multicultural Engagement, and Multiracial Discrimination. The 5-subscale structure of the MEM was supported by a combination of exploratory and confirmatory factor analyses. Evidence of criterion-related validity was partially supported with MEM subscales correlating with measures of racial diversity in one's social network, color-blind racial attitude, psychological distress, and identity conflict. Evidence of discriminant validity was supported with MEM subscales not correlating with impression management. Implications for future research and suggestions for utilization of the MEM in clinical practice with multiracial adults are discussed. (c) 2016 APA, all rights reserved).

  15. The Outpatient Experience Questionnaire of comprehensive public hospital in China: development, validity and reliability.

    PubMed

    Hu, Yinhuan; Zhang, Zixia; Xie, Jinzhu; Wang, Guanping

    2017-02-01

    The objective of this study is to describe the development of the Outpatient Experience Questionnaire (OPEQ) and to assess the validity and reliability of the scale. Literature review, patient interviews, Delphi method and Cross-sectional validation survey. Six comprehensive public hospitals in China. The survey was carried out on a sample of 600 outpatients. Acceptability of the questionnaire was assessed according to the overall response rate, item non-response rate and the average completion time. Correlation coefficients and confirmatory factor analysis were used to test construct validity. Delphi method was used to assess the content validity of the questionnaire. Cronbach's coefficient alpha and split-half reliability coefficient were used to estimate the internal reliability of the questionnaire. The overall response rate was 97.2% and the item non-response rate ranged from 0% to 0.3%. The mean completion time was 6 min. The Spearman correlations of item-total score ranged from 0.466 to 0.765. The results of confirmatory factor analysis showed that all items had factor loadings above 0.40 and the dimension intercorrelation ranged from 0.449 to 0.773, the goodness of fit of the questionnaire was reasonable. The overall authority grade of expert consultation was 0.80 and Kendall's coefficient of concordance W was 0.186. The Cronbach's coefficients alpha of six dimensions ranged from 0.708 to 0.895, the split-half reliability coefficient (Spearman-Brown coefficient) was 0.969. The OPEQ is a promising instrument covering the most important aspects which influence outpatient experiences of comprehensive public hospital in China. It has good evidence for acceptability, validity and reliability. © The Author 2016. Published by Oxford University Press in association with the International Society for Quality in Health Care. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com

  16. Reactivity loss validation of high burn-up PWR fuels with pile-oscillation experiments in MINERVE

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Leconte, P.; Vaglio-Gaudard, C.; Eschbach, R.

    2012-07-01

    The ALIX experimental program relies on the experimental validation of the spent fuel inventory, by chemical analysis of samples irradiated in a PWR between 5 and 7 cycles, and also on the experimental validation of the spent fuel reactivity loss with bum-up, obtained by pile-oscillation measurements in the MINERVE reactor. These latter experiments provide an overall validation of both the fuel inventory and of the nuclear data responsible for the reactivity loss. This program offers also unique experimental data for fuels with a burn-up reaching 85 GWd/t, as spent fuels in French PWRs never exceeds 70 GWd/t up to now.more » The analysis of these experiments is done in two steps with the APOLLO2/SHEM-MOC/CEA2005v4 package. In the first one, the fuel inventory of each sample is obtained by assembly calculations. The calculation route consists in the self-shielding of cross sections on the 281 energy group SHEM mesh, followed by the flux calculation by the Method Of Characteristics in a 2D-exact heterogeneous geometry of the assembly, and finally a depletion calculation by an iterative resolution of the Bateman equations. In the second step, the fuel inventory is used in the analysis of pile-oscillation experiments in which the reactivity of the ALIX spent fuel samples is compared to the reactivity of fresh fuel samples. The comparison between Experiment and Calculation shows satisfactory results with the JEFF3.1.1 library which predicts the reactivity loss within 2% for burn-up of {approx}75 GWd/t and within 4% for burn-up of {approx}85 GWd/t. (authors)« less

  17. A Validation Study of the Adolescent Dissociative Experiences Scale

    ERIC Educational Resources Information Center

    Keck Seeley, Susan. M.; Perosa, Sandra, L.; Perosa, Linda, M.

    2004-01-01

    Objective: The purpose of this study was to further the validation process of the Adolescent Dissociative Experiences Scale (A-DES). In this study, a 6-item Likert response format with descriptors was used when responding to the A-DES rather than the 11-item response format used in the original A-DES. Method: The internal reliability and construct…

  18. Style preference survey: a report on the psychometric properties and a cross-validation experiment.

    PubMed

    Smith, Sherri L; Ricketts, Todd; McArdle, Rachel A; Chisolm, Theresa H; Alexander, Genevieve; Bratt, Gene

    2013-02-01

    Several self-report measures exist that target different aspects of outcomes for hearing aid use. Currently, no comprehensive questionnaire specifically assesses factors that may be important for differentiating outcomes pertaining to hearing aid style. The goal of this work was to develop the Style Preference Survey (SPS), a questionnaire aimed at outcomes associated with hearing aid style differences. Two experiments were conducted. After initial item development, Experiment 1 was conducted to refine the items and to determine its psychometric properties. Experiment 2 was designed to cross-validate the findings from the initial experiment. An observational design was used in both experiments. Participants who wore traditional, custom-fitted (TC) or open-canal (OC) style hearing aids from 3 mo to 3 yr completed the initial experiment. One-hundred and eighty-four binaural hearing aid users (120 of whom wore TC hearing aids and 64 of whom wore OC hearing aids) participated. A new sample of TC and OC users (n = 185) participated in the cross-validation experiment. Currently available self-report measures were reviewed to identify items that might differentiate between hearing aid styles, particularly preference for OC versus TC hearing aid styles. A total of 15 items were selected and modified from available self-report measures. An additional 55 items were developed through consensus of six audiologists for the initial version of the SPS. In the first experiment, the initial SPS version was mailed to 550 veterans who met the inclusion criteria. A total of 184 completed the SPS. Approximately three weeks later, a subset of participants (n = 83) completed the SPS a second time. Basic analyses were conducted to evaluate the psychometric properties of the SPS including subscale structure, internal consistency, test-retest reliability, and responsiveness. Based on the results of Experiment 1, the SPS was revised. A cross-validation experiment was then conducted using the

  19. The Development and Validation of the Game User Experience Satisfaction Scale (GUESS).

    PubMed

    Phan, Mikki H; Keebler, Joseph R; Chaparro, Barbara S

    2016-12-01

    The aim of this study was to develop and psychometrically validate a new instrument that comprehensively measures video game satisfaction based on key factors. Playtesting is often conducted in the video game industry to help game developers build better games by providing insight into the players' attitudes and preferences. However, quality feedback is difficult to obtain from playtesting sessions without a quality gaming assessment tool. There is a need for a psychometrically validated and comprehensive gaming scale that is appropriate for playtesting and game evaluation purposes. The process of developing and validating this new scale followed current best practices of scale development and validation. As a result, a mixed-method design that consisted of item pool generation, expert review, questionnaire pilot study, exploratory factor analysis (N = 629), and confirmatory factor analysis (N = 729) was implemented. A new instrument measuring video game satisfaction, called the Game User Experience Satisfaction Scale (GUESS), with nine subscales emerged. The GUESS was demonstrated to have content validity, internal consistency, and convergent and discriminant validity. The GUESS was developed and validated based on the assessments of over 450 unique video game titles across many popular genres. Thus, it can be applied across many types of video games in the industry both as a way to assess what aspects of a game contribute to user satisfaction and as a tool to aid in debriefing users on their gaming experience. The GUESS can be administered to evaluate user satisfaction of different types of video games by a variety of users. © 2016, Human Factors and Ergonomics Society.

  20. Thyroid-specific questions on work ability showed known-groups validity among Danes with thyroid diseases.

    PubMed

    Nexo, Mette Andersen; Watt, Torquil; Bonnema, Steen Joop; Hegedüs, Laszlo; Rasmussen, Åse Krogh; Feldt-Rasmussen, Ulla; Bjorner, Jakob Bue

    2015-07-01

    We aimed to identify the best approach to work ability assessment in patients with thyroid disease by evaluating the factor structure, measurement equivalence, known-groups validity, and predictive validity of a broad set of work ability items. Based on the literature and interviews with thyroid patients, 24 work ability items were selected from previous questionnaires, revised, or developed anew. Items were tested among 632 patients with thyroid disease (non-toxic goiter, toxic nodular goiter, Graves' disease (with or without orbitopathy), autoimmune hypothyroidism, and other thyroid diseases), 391 of which had participated in a study 5 years previously. Responses to select items were compared to general population data. We used confirmatory factor analyses for categorical data, logistic regression analyses and tests of differential item function, and head-to-head comparisons of relative validity in distinguishing known groups. Although all work ability items loaded on a common factor, the optimal factor solution included five factors: role physical, role emotional, thyroid-specific limitations, work limitations (without disease attribution), and work performance. The scale on thyroid-specific limitations showed the most power in distinguishing clinical groups and time since diagnosis. A global single item proved useful for comparisons with the general population, and a thyroid-specific item predicted labor market exclusion within the next 5 years (OR 5.0, 95 % CI 2.7-9.1). Items on work limitations with attribution to thyroid disease were most effective in detecting impact on work ability and showed good predictive validity. Generic work ability items remain useful for general population comparisons.

  1. The Sensed Presence Questionnaire (SenPQ): initial psychometric validation of a measure of the “Sensed Presence” experience

    PubMed Central

    Bell, Vaughan

    2017-01-01

    Background The experience of ‘sensed presence’—a feeling or sense that another entity, individual or being is present despite no clear sensory or perceptual evidence—is known to occur in the general population, appears more frequently in religious or spiritual contexts, and seems to be prominent in certain psychiatric or neurological conditions and may reflect specific functions of social cognition or body-image representation systems in the brain. Previous research has relied on ad-hoc measures of the experience and no specific psychometric scale to measure the experience exists to date. Methods Based on phenomenological description in the literature, we created the 16-item Sensed Presence Questionnaire (SenPQ). We recruited participants from (i) a general population sample, and; (ii) a sample including specific selection for religious affiliation, to complete the SenPQ and additional measures of well-being, schizotypy, social anxiety, social imagery, and spiritual experience. We completed an analysis to test internal reliability, the ability of the SenPQ to distinguish between religious and non-religious participants, and whether the SenPQ was specifically related to positive schizotypical experiences and social imagery. A factor analysis was also conducted to examine underlying latent variables. Results The SenPQ was found to be reliable and valid, with religious participants significantly endorsing more items than non-religious participants, and the scale showing a selective relationship with construct relevant measures. Principal components analysis indicates two potential underlying factors interpreted as reflecting ‘benign’ and ‘malign’ sensed presence experiences. Discussion The SenPQ appears to be a reliable and valid measure of sensed presence experience although further validation in neurological and psychiatric conditions is warranted. PMID:28367379

  2. Assessing decentering: validation, psychometric properties, and clinical usefulness of the Experiences Questionnaire in a Spanish sample.

    PubMed

    Soler, Joaquim; Franquesa, Alba; Feliu-Soler, Albert; Cebolla, Ausias; García-Campayo, Javier; Tejedor, Rosa; Demarzo, Marcelo; Baños, Rosa; Pascual, Juan Carlos; Portella, Maria J

    2014-11-01

    Decentering is defined as the ability to observe one's thoughts and feelings in a detached manner. The Experiences Questionnaire (EQ) is a self-report instrument that originally assessed decentering and rumination. The purpose of this study was to evaluate the psychometric properties of the Spanish version of EQ-Decentering and to explore its clinical usefulness. The 11-item EQ-Decentering subscale was translated into Spanish and psychometric properties were examined in a sample of 921 adult individuals, 231 with psychiatric disorders and 690 without. The subsample of nonpsychiatric participants was also split according to their previous meditative experience (meditative participants, n=341; and nonmeditative participants, n=349). Additionally, differences among these three subgroups were explored to determine clinical validity of the scale. Finally, EQ-Decentering was administered twice in a group of borderline personality disorder, before and after a 10-week mindfulness intervention. Confirmatory factor analysis indicated acceptable model fit, sbχ(2)=243.8836 (p<.001), CFI=.939, GFI=.936, SRMR=.040, and RMSEA=.06 (.060-.077), and psychometric properties were found to be satisfactory (reliability: Cronbach's α=.893; convergent validity: r>.46; and divergent validity: r<-.35). The scale detected changes in decentering after a 10-session intervention in mindfulness (t=-4.692, p<.00001). Differences among groups were significant (F=134.8, p<.000001), where psychiatric participants showed the lowest scores compared to nonpsychiatric meditative and nonmeditative participants. The Spanish version of the EQ-Decentering is a valid and reliable instrument to assess decentering either in clinical and nonclinical samples. In addition, the findings show that EQ-Decentering seems an adequate outcome instrument to detect changes after mindfulness-based interventions. Copyright © 2014. Published by Elsevier Ltd.

  3. In-Space Structural Validation Plan for a Stretched-Lens Solar Array Flight Experiment

    NASA Technical Reports Server (NTRS)

    Pappa, Richard S.; Woods-Vedeler, Jessica A.; Jones, Thomas W.

    2001-01-01

    This paper summarizes in-space structural validation plans for a proposed Space Shuttle-based flight experiment. The test article is an innovative, lightweight solar array concept that uses pop-up, refractive stretched-lens concentrators to achieve a power/mass density of at least 175 W/kg, which is more than three times greater than current capabilities. The flight experiment will validate this new technology to retire the risk associated with its first use in space. The experiment includes structural diagnostic instrumentation to measure the deployment dynamics, static shape, and modes of vibration of the 8-meter-long solar array and several of its lenses. These data will be obtained by photogrammetry using the Shuttle payload-bay video cameras and miniature video cameras on the array. Six accelerometers are also included in the experiment to measure base excitations and small-amplitude tip motions.

  4. [Validation study of the Depressive Experience Questionnaire].

    PubMed

    Atger, F; Frasson, G; Loas, G; Guibourgé, S; Corcos, M; Perez Diaz, F; Speranza, M; Venisse, J-L; Lang, F; Stephan, Ph; Bizouard, P; Flament, M; Jeammet, Ph

    2003-01-01

    Sidney Blatt, considering as being insufficient the categorical-symptomatic approach of depression, has worked out a theory of depression and psychopathology that integrates the contributions of psychoanalysis as well as cognitive and developmental psychology. Within a broad psychoanalytic framework, Blatt's formulation focus on the quality of interpersonal relationship, the nature of object representation and early life experiences. Personality development is viewed as the consequence of the interaction of 2 basic developmental tasks: the establishment of the capacity to form stable, enduring, mutually satisfying interpersonal relationships and the achievement of a differentiated, realistic, essentially positive identity. The relationship between these 2 developmental lines involves a complex dialectical process during which progress in each line is essential for progress in the other and which contributes to the development of both a sense of identity and the capacity for interpersonal relatedness. These developmental lines permit not only to define an during individual's primary personality configuration but also enable to identify cognitive structures that are inherent in various forms of psychopathology, including depression. Disruptions at different developmental stages create vulnerability to different subsequent psychological disturbances. Blatt characterised as anaclitic or dependent the axis concerned with interpersonal relationship and as introjective or self-critical the axis concerned with development of the sense of self and identity. Depressive Experience Questionnaire was developed by Blatt et al. to determine the validity of this model of psychopathology which emphazises continuities between normal and pathological forms of depression. The instrument was developed by Blatt et al. by assembling a pool of items describing experiences frequently reported by depressed individual. Sixty-six items were selected and administered to a large nonclinical

  5. Explicating Experience: Development of a Valid Scale of Past Hazard Experience for Tornadoes.

    PubMed

    Demuth, Julie L

    2018-03-23

    People's past experiences with a hazard theoretically influence how they approach future risks. Yet, past hazard experience has been conceptualized and measured in wide-ranging, often simplistic, ways, resulting in mixed findings about its relationship with risk perception. This study develops a scale of past hazard experiences, in the context of tornadoes, that is content and construct valid. A conceptual definition was developed, a set of items were created to measure one's most memorable and multiple tornado experiences, and the measures were evaluated through two surveys of the public who reside in tornado-prone areas. Four dimensions emerged of people's most memorable experience, reflecting their awareness of the tornado risk that day, their personalization of the risk, the intrusive impacts on them personally, and impacts experienced vicariously through others. Two dimensions emerged of people's multiple experiences, reflecting common types of communication received and negative emotional responses. These six dimensions are novel in that they capture people's experience across the timeline of a hazard as well as intangible experiences that are both direct and indirect. The six tornado experience dimensions were correlated with tornado risk perceptions measured as cognitive-affective and as perceived probability of consequences. The varied experience-risk perception results suggest that it is important to understand the nuances of these concepts and their relationships. This study provides a foundation for future work to continue explicating past hazard experience, across different risk contexts, and for understanding its effect on risk assessment and responses. © 2018 Society for Risk Analysis.

  6. SMAP Validation Experiment 2015 (SMAPVEX15)

    NASA Astrophysics Data System (ADS)

    Colliander, A.; Jackson, T. J.; Cosh, M. H.; Misra, S.; Crow, W. T.; Chae, C. S.; Moghaddam, M.; O'Neill, P. E.; Entekhabi, D.; Yueh, S. H.

    2015-12-01

    NASA's (National Aeronautics and Space Administration) Soil Moisture Active Passive (SMAP) mission was launched in January 2015. The objective of the mission is global mapping of soil moisture and freeze/thaw state. For soil moisture algorithm validation, the SMAP project and NASA coordinated SMAPVEX15 around the Walnut Gulch Experimental Watershed (WGEW) in Tombstone, Arizona on August 1-19, 2015. The main goals of SMAPVEX15 are to understand the effects and contribution of heterogeneity on the soil moisture retrievals, evaluate the impact of known RFI sources on retrieval, and analyze the brightness temperature product calibration and heterogeneity effects. Additionally, the campaign aims to contribute to the validation of GPM (Global Precipitation Mission) data products. The campaign will feature three airborne microwave instruments: PALS (Passive Active L-band System), UAVSAR (Uninhabited Aerial Vehicle Synthetic Aperture Radar) and AirMOSS (Airborne Microwave Observatory of Subcanopy and Subsurface). PALS has L-band radiometer and radar, and UAVSAR and AirMOSS have L- and P-band synthetic aperture radars, respectively. The PALS instrument will map the area on seven days coincident with SMAP overpasses; UAVSAR and AirMOSS on four days. WGEW was selected as the experiment site due to the rainfall patterns in August and existing dense networks of precipitation gages and soil moisture sensors. An additional temporary network of approximately 80 soil moisture stations was deployed in the region. Rainfall observations were supplemented with two X-band mobile scanning radars, approximately 25 tipping bucket rain gauges, three laser disdrometers, and three vertically-profiling K-band radars. Teams were on the field to take soil moisture samples for gravimetric soil moisture, bulk density and rock fraction determination as well as to measure surface roughness and vegetation water content. In this talk we will present preliminary results from the experiment including

  7. Development and validation of the FertiMed questionnaire assessing patients' experiences with hormonal fertility medication.

    PubMed

    Lankreijer, K; D'Hooghe, T; Sermeus, W; van Asseldonk, F P M; Repping, S; Dancet, E A F

    2016-08-01

    Can a valid and reliable questionnaire be developed to assess patients' experiences with all of the characteristics of hormonal fertility medication valued by them? The FertiMed questionnaire is a valid and reliable tool that assesses patients' experiences with all medication characteristics valued by them and that can be used for all hormonal fertility medications, irrespective of their route of administration. Hormonal fertility medications cause emotional strain and differ in their dosage regime and route of administration, although they often have comparable effectiveness. Medication experiences of former patients would be informative for medication choices. A recent literature review showed that there is no trustworthy tool to compare patients' experiences of medications with differing routes of administration, regarding all medication characteristics which patients value. The items of the new FertiMed questionnaire were generated by literature review and 23 patient interviews. In 2013, 411 IVF-patients were asked to retrospectively complete the FertiMed questionnaire to assess 1 out of the 8 different medications used for ovarian stimulation, induction of pituitary quiescence, ovulation triggering or luteal support. In total, 276 patients (on average 35 per medication) from 2 university fertility clinics (Belgium, the Netherlands) completed the FertiMed questionnaire (67% response rate). The FertiMed questionnaire questioned whether items were valued by patients and whether these items were experienced while using the assessed medication. Hence, the final outcome 'Experiences with Valued Aspects Scores' (EVAS) combined importance and experience ratings. The content and face validity, reliability, feasibility and discriminative potential of the FertiMed questionnaire were tested and changes were made accordingly. Patient interviews defined 51 items relevant to seven medication characteristics previously proved to be important to patients. Item analysis deleted

  8. [Caregiver's health: adaption and validation in a Spanish population of the Experience of Caregiving Inventory (ECI)].

    PubMed

    Crespo-Maraver, Mariacruz; Doval, Eduardo; Fernández-Castro, Jordi; Giménez-Salinas, Jordi; Prat, Gemma; Bonet, Pere

    2018-04-04

    To adapt and to validate the Experience of Caregiving Inventory (ECI) in a Spanish population, providing empirical evidence of its internal consistency, internal structure and validity. Psychometric validation of the adapted version of the ECI. One hundred and seventy-two caregivers (69.2% women), mean age 57.51 years (range: 21-89) participated. Demographic and clinical data, standardized measures (ECI, suffering scale of SCL-90-R, Zarit burden scale) were used. The two scales of negative evaluation of the ECI most related to serious mental disorders (disruptive behaviours [DB] and negative symptoms [NS]) and the two scales of positive appreciation (positive personal experiences [PPE], and good aspects of the relationship [GAR]) were analyzed. Exploratory structural equation modelling was used to analyze the internal structure. The relationship between the ECI scales and the SCL-90-R and Zarit scores was also studied. The four-factor model presented a good fit. Cronbach's alpha (DB: 0.873; NS: 0.825; PPE: 0.720; GAR: 0.578) showed a higher homogeneity in the negative scales. The SCL-90-R scores correlated with the negative ECI scales, and none of the ECI scales correlated with the Zarit scale. The Spanish version of the ECI can be considered a valid, reliable, understandable and feasible self-report measure for its administration in the health and community context. Copyright © 2018 SESPAS. Publicado por Elsevier España, S.L.U. All rights reserved.

  9. Panamanian women׳s experience of vaginal examination in labour: A questionnaire validation.

    PubMed

    Bonilla-Escobar, Francisco J; Ortega-Lenis, Delia; Rojas-Mirquez, Johanna C; Ortega-Loubon, Christian

    2016-05-01

    to validate a tool that allows healthcare providers to obtain accurate information regarding Panamanian women׳s thoughts and feelings about vaginal examination during labour that can be used in other Latin-American countries. validation study based on a database from a cross-sectional study carried out in two tertiary care hospitals in Panama City, Panama. Women in the immediate postpartum period who had spontaneous labour onset and uncomplicated deliveries were included in the study from April to August 2008. Researchers used a survey designed by Lewin et al. that included 20 questions related to a patient׳s experience during a vaginal examination. five constructs (factors) related to a patient׳s experience of vaginal examination during labour were identified: Approval (Alpha Cronbach׳s 0.72), Perception (0.67), Rejection (0.40), Consent (0.51), and Stress (0.20). it was demonstrated the validity of the scale and its constructs used to obtain information related to vaginal examination during labour, including patients' experiences with examination and healthcare staff performance. utilisation of the scale will allow institutions to identify items that need improvement and address these areas in order to promote the best care for patients in labour. Copyright © 2016 Elsevier Ltd. All rights reserved.

  10. Validating the BISON fuel performance code to integral LWR experiments

    DOE PAGES

    Williamson, R. L.; Gamble, K. A.; Perez, D. M.; ...

    2016-03-24

    BISON is a modern finite element-based nuclear fuel performance code that has been under development at the Idaho National Laboratory (INL) since 2009. The code is applicable to both steady and transient fuel behavior and has been used to analyze a variety of fuel forms in 1D spherical, 2D axisymmetric, or 3D geometries. Code validation is underway and is the subject of this study. A brief overview of BISON’s computational framework, governing equations, and general material and behavioral models is provided. BISON code and solution verification procedures are described, followed by a summary of the experimental data used to datemore » for validation of Light Water Reactor (LWR) fuel. Validation comparisons focus on fuel centerline temperature, fission gas release, and rod diameter both before and following fuel-clad mechanical contact. Comparisons for 35 LWR rods are consolidated to provide an overall view of how the code is predicting physical behavior, with a few select validation cases discussed in greater detail. Our results demonstrate that 1) fuel centerline temperature comparisons through all phases of fuel life are very reasonable with deviations between predictions and experimental data within ±10% for early life through high burnup fuel and only slightly out of these bounds for power ramp experiments, 2) accuracy in predicting fission gas release appears to be consistent with state-of-the-art modeling and with the involved uncertainties and 3) comparison of rod diameter results indicates a tendency to overpredict clad diameter reduction early in life, when clad creepdown dominates, and more significantly overpredict the diameter increase late in life, when fuel expansion controls the mechanical response. In the initial rod diameter comparisons they were unsatisfactory and have lead to consideration of additional separate effects experiments to better understand and predict clad and fuel mechanical behavior. Results from this study are being used to

  11. Spanish and Catalan translation, cultural adaptation and validation of the Picker Patient Experience Questionnaire-15.

    PubMed

    Bertran, M J; Viñarás, M; Salamero, M; Garcia, F; Graham, C; McCulloch, A; Escarrabill, J

    To develop and test a culturally adapted core set of questions to measure patients' experience after in-patient care. Following the methodology recommended by international guides, a basic set of patient experience questions, selected from Picker Institute Europe questionnaires (originally in English), was translated to Spanish and Catalan. Acceptability, construct validity and reliability of the adapted questionnaire were assessed via a cross-sectional validation study. The inclusion criteria were patients aged >18 years, discharged within one week to one month prior to questionnaire sending and whose email was available. Day cases, emergency department patients and deaths were excluded. Invitations were sent by email (N=876) and questionnaire was fulfilled through an online platform. An automatic reminder was sent 5 days later to non-respondents. A questionnaire, in Spanish and Catalan, with adequate conceptual and linguistic equivalence was obtained. Response rate was 44.4% (389 responses). The correlation matrix was factorable. Four factors were extracted with Parallel Analysis, which explained 43% of the total variance. First factor: information and communication received during discharge. Second factor: low sensitivity attitudes of professionals. Third factor: assessment of communication of medical and nursing staff. Fourth factor: global items. The value of the Cronbach alpha was 0.84, showing a high internal consistency. The obtained experience patient questionnaire, in Spanish and Catalan, shows good results in the psychometric properties evaluated and could be a useful tool to identify opportunities for health care improvement in our context. Email could become a feasible tool for greater patient participation in everything that concerns his health. Copyright © 2018 SECA. Publicado por Elsevier España, S.L.U. All rights reserved.

  12. Supersonic Coaxial Jet Experiment for CFD Code Validation

    NASA Technical Reports Server (NTRS)

    Cutler, A. D.; Carty, A. A.; Doerner, S. E.; Diskin, G. S.; Drummond, J. P.

    1999-01-01

    A supersonic coaxial jet facility has been designed to provide experimental data suitable for the validation of CFD codes used to analyze high-speed propulsion flows. The center jet is of a light gas and the coflow jet is of air, and the mixing layer between them is compressible. Various methods have been employed in characterizing the jet flow field, including schlieren visualization, pitot, total temperature and gas sampling probe surveying, and RELIEF velocimetry. A Navier-Stokes code has been used to calculate the nozzle flow field and the results compared to the experiment.

  13. An Overlooked Population in Community College: International Students' (In)Validation Experiences With Academic Advising

    ERIC Educational Resources Information Center

    Zhang, Yi

    2016-01-01

    Objective: Guided by validation theory, this study aims to better understand the role that academic advising plays in international community college students' adjustment. More specifically, this study investigated how academic advising validates or invalidates their academic and social experiences in a community college context. Method: This…

  14. Experiences using IAEA Code of practice for radiation sterilization of tissue allografts: Validation and routine control

    NASA Astrophysics Data System (ADS)

    Hilmy, N.; Febrida, A.; Basril, A.

    2007-11-01

    Problems of tissue allografts in using International Standard (ISO) 11137 for validation of radiation sterilization dose (RSD) are limited and low numbers of uniform samples per production batch, those are products obtained from one donor. Allograft is a graft transplanted between two different individuals of the same species. The minimum number of uniform samples needed for verification dose (VD) experiment at the selected sterility assurance level (SAL) per production batch according to the IAEA Code is 20, i.e., 10 for bio-burden determination and the remaining 10 for sterilization test. Three methods of the IAEA Code have been used for validation of RSD, i.e., method A1 that is a modification of method 1 of ISO 11137:1995, method B (ISO 13409:1996), and method C (AAMI TIR 27:2001). This paper describes VD experiments using uniform products obtained from one cadaver donor, i.e., cancellous bones, demineralized bone powders and amnion grafts from one life donor. Results of the verification dose experiments show that RSD is 15.4 kGy for cancellous and demineralized bone grafts and 19.2 kGy for amnion grafts according to method A1 and 25 kGy according to methods B and C.

  15. Examining students' views about validity of experiments: From introductory to Ph.D. students

    NASA Astrophysics Data System (ADS)

    Hu, Dehui; Zwickl, Benjamin M.

    2018-06-01

    We investigated physics students' epistemological views on measurements and validity of experimental results. The roles of experiments in physics have been underemphasized in previous research on students' personal epistemology, and there is a need for a broader view of personal epistemology that incorporates experiments. An epistemological framework incorporating the structure, methodology, and validity of scientific knowledge guided the development of an open-ended survey. The survey was administered to students in algebra-based and calculus-based introductory physics courses, upper-division physics labs, and physics Ph.D. students. Within our sample, we identified several differences in students' ideas about validity and uncertainty in measurement. The majority of introductory students justified the validity of results through agreement with theory or with results from others. Alternatively, Ph.D. students frequently justified the validity of results based on the quality of the experimental process and repeatability of results. When asked about the role of uncertainty analysis, introductory students tended to focus on the representational roles (e.g., describing imperfections, data variability, and human mistakes). However, advanced students focused on the inferential roles of uncertainty analysis (e.g., quantifying reliability, making comparisons, and guiding refinements). The findings suggest that lab courses could emphasize a variety of approaches to establish validity, such as by valuing documentation of the experimental process when evaluating the quality of student work. In order to emphasize the role of uncertainty in an authentic way, labs could provide opportunities to iterate, make repeated comparisons, and make decisions based on those comparisons.

  16. The inventory for déjà vu experiences assessment. Development, utility, reliability, and validity.

    PubMed

    Sno, H N; Schalken, H F; de Jonghe, F; Koeter, M W

    1994-01-01

    In this article the development, utility, reliability, and validity of the Inventory for Déjà vu Experiences Assessment (IDEA) are described. The IDEA is a 23-item self-administered questionnaire consisting of a general section of nine questions and qualitative section of 14 questions. The latter questions comprise 48 topics. The questionnaire appeared to be a user-friendly instrument with satisfactory to good reliability and validity. The IDEA permits the study of quantitative and qualitative characteristics of déjà vu experiences.

  17. Methodology and issues of integral experiments selection for nuclear data validation

    NASA Astrophysics Data System (ADS)

    Tatiana, Ivanova; Ivanov, Evgeny; Hill, Ian

    2017-09-01

    Nuclear data validation involves a large suite of Integral Experiments (IEs) for criticality, reactor physics and dosimetry applications. [1] Often benchmarks are taken from international Handbooks. [2, 3] Depending on the application, IEs have different degrees of usefulness in validation, and usually the use of a single benchmark is not advised; indeed, it may lead to erroneous interpretation and results. [1] This work aims at quantifying the importance of benchmarks used in application dependent cross section validation. The approach is based on well-known General Linear Least Squared Method (GLLSM) extended to establish biases and uncertainties for given cross sections (within a given energy interval). The statistical treatment results in a vector of weighting factors for the integral benchmarks. These factors characterize the value added by a benchmark for nuclear data validation for the given application. The methodology is illustrated by one example, selecting benchmarks for 239Pu cross section validation. The studies were performed in the framework of Subgroup 39 (Methods and approaches to provide feedback from nuclear and covariance data adjustment for improvement of nuclear data files) established at the Working Party on International Nuclear Data Evaluation Cooperation (WPEC) of the Nuclear Science Committee under the Nuclear Energy Agency (NEA/OECD).

  18. Airborne Observations and Satellite Validation: INTEX-A Experience and INTEX-B Plans

    NASA Technical Reports Server (NTRS)

    Crawford, James H.; Singh, Hanwant B.; Brune, William H.; Jacob, Daniel J.

    2005-01-01

    Intercontinental Chemical Transport Experiment (INTEX; http://cloudl.arc.nasa.gov) is an ongoing two-phase integrated atmospheric field experiment being performed over North America (NA). Its first phase (INTEX-A) was performed in the summer of 2004 and the second phase (INTEX-B) is planned for the early spring of 2006. The main goal of INTEX-NA is to understand the transport and transformation of gases and aerosols on transcontinental/intercontinental scales and to assess their impact on air quality and climate. Central to achieving this goal is the need to relate space-based observations with those from airborne and surface platforms. During INTEX-A, NASA s DC-8 was joined by some dozen other aircraft from a large number of European and North American partners to focus on the outflow of pollution from NA to the Atlantic. Several instances of Asian pollution over NA were also encountered. INTEX-A flight planning extensively relied on satellite observations and in turn Satellite validation (Terra, Aqua, and Envisat) was given high priority. Over 20 validation profiles were successfully carried out. DC-8 sampling of smoke from Alaskan fires and formaldehyde over forested regions, and simultaneous satellite observations of these provided excellent opportunities for the interplay of these platforms. The planning for INTEX-5 is currently underway, and a vast majority of "standard" and "research" products to be retrieved from Aura instruments will be measured during INTEX-B throughout the troposphere. INTEX-B will focus on the inflow of pollution from Asia to North America and validation of satellite observations with emphasis on Aura. Several national and international partners are expected to coordinate activities with INTEX-B, and we expect its scope to expand in the coming months. An important new development involves partnership with an NSF-sponsored campaign called MIRAGE (Megacity Impacts on Regional and Global Environments- Mexico City Pollution Outflow Field

  19. Evaluation of Fission Product Critical Experiments and Associated Biases for Burnup Credit Validation

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Mueller, Don; Rearden, Bradley T; Reed, Davis Allan

    2010-01-01

    One of the challenges associated with implementation of burnup credit is the validation of criticality calculations used in the safety evaluation; in particular the availability and use of applicable critical experiment data. The purpose of the validation is to quantify the relationship between reality and calculated results. Validation and determination of bias and bias uncertainty require the identification of sets of critical experiments that are similar to the criticality safety models. A principal challenge for crediting fission products (FP) in a burnup credit safety evaluation is the limited availability of relevant FP critical experiments for bias and bias uncertainty determination.more » This paper provides an evaluation of the available critical experiments that include FPs, along with bounding, burnup-dependent estimates of FP biases generated by combining energy dependent sensitivity data for a typical burnup credit application with the nuclear data uncertainty information distributed with SCALE 6. A method for determining separate bias and bias uncertainty values for individual FPs and illustrative results is presented. Finally, a FP bias calculation method based on data adjustment techniques and reactivity sensitivity coefficients calculated with the SCALE sensitivity/uncertainty tools and some typical results is presented. Using the methods described in this paper, the cross-section bias for a representative high-capacity spent fuel cask associated with the ENDF/B-VII nuclear data for 16 most important stable or near stable FPs is predicted to be no greater than 2% of the total worth of the 16 FPs, or less than 0.13 % k/k.« less

  20. Patient experiences questionnaire for interdisciplinary treatment for substance dependence (PEQ-ITSD): reliability and validity following a national survey in Norway.

    PubMed

    Haugum, Mona; Iversen, Hilde Hestad; Bjertnaes, Oyvind; Lindahl, Anne Karin

    2017-02-20

    Patient experiences are an important aspect of health care quality, but there is a lack of validated instruments for their measurement in the substance dependence literature. A new questionnaire to measure inpatients' experiences of interdisciplinary treatment for substance dependence has been developed in Norway. The aim of this study was to psychometrically test the new questionnaire, using data from a national survey in 2013. The questionnaire was developed based on a literature review, qualitative interviews with patients, expert group discussions and pretesting. Data were collected in a national survey covering all residential facilities with inpatients in treatment for substance dependence in 2013. Data quality and psychometric properties were assessed, including ceiling effects, item missing, exploratory factor analysis, and tests of internal consistency reliability, test-retest reliability and construct validity. The sample included 978 inpatients present at 98 residential institutions. After correcting for excluded patients (n = 175), the response rate was 91.4%. 28 out of 33 items had less than 20.5% of missing data or replies in the "not applicable" category. All but one item met the ceiling effect criterion of less than 50.0% of the responses in the most favorable category. Exploratory factor analysis resulted in three scales: "treatment and personnel", "milieu" and "outcome". All scales showed satisfactory internal consistency reliability (Cronbach's alpha ranged from 0.75-0.91) and test-retest reliability (ICC ranged from 0.82-0.85). 17 of 18 significant associations between single variables and the scales supported construct validity of the PEQ-ITSD. The content validity of the PEQ-ITSD was secured by a literature review, consultations with an expert group and qualitative interviews with patients. The PEQ-ITSD was used in a national survey in Norway in 2013 and psychometric testing showed that the instrument had satisfactory internal consistency

  1. Observations with the ROWS instrument during the Grand Banks calibration/validation experiments

    NASA Technical Reports Server (NTRS)

    Vandemark, D.; Chapron, B.

    1994-01-01

    As part of a global program to validate the ocean surface sensors on board ERS-1, a joint experiment on the Grand Banks of Newfoundland was carried out in Nov. 1991. The principal objective was to provide a field validation of ERS-1 Synthetic Aperture Radar (SAR) measurement of ocean surface structure. The NASA-P3 aircraft measurements made during this experiment provide independent measurements of the ocean surface along the validation swath. The Radar Ocean Wave Spectrometer (ROWS) is a radar sensor designed to measure direction of the long wave components using spectral analysis of the tilt induced radar backscatter modulation. This technique greatly differs from SAR and thus, provides a unique set of measurements for use in evaluating SAR performance. Also, an altimeter channel in the ROWS gives simultaneous information on the surface wave height and radar mean square slope parameter. The sets of geophysical parameters (wind speed, significant wave height, directional spectrum) are used to study the SAR's ability to accurately measure ocean gravity waves. The known distortion imposed on the true directional spectrum by the SAR imaging mechanism is discussed in light of the direct comparisons between ERS-1 SAR, airborne Canadian Center for Remote Sensing (CCRS) SAR, and ROWS spectra and the use of the nonlinear ocean SAR transform.

  2. The Development and Validation of a Life Experience Inventory for the Identification of Creative Electrical Engineers.

    ERIC Educational Resources Information Center

    Michael, William B.; Colson, Kenneth R.

    1979-01-01

    The construction and validation of the Life Experience Inventory (LEI) for the identification of creative electrical engineers are described. Using the number of patents held or pending as a criterion measure, the LEI was found to have high concurrent validity. (JKS)

  3. Closing the patient experience chasm: A two-level validation of the Consumer Quality Index Inpatient Hospital Care.

    PubMed

    Smirnova, Alina; Lombarts, Kiki M J M H; Arah, Onyebuchi A; van der Vleuten, Cees P M

    2017-10-01

    Evaluation of patients' health care experiences is central to measuring patient-centred care. However, different instruments tend to be used at the hospital or departmental level but rarely both, leading to a lack of standardization of patient experience measures. To validate the Consumer Quality Index (CQI) Inpatient Hospital Care for use on both department and hospital levels. Using cross-sectional observational data, we investigated the internal validity of the questionnaire using confirmatory factor analyses (CFA), and the generalizability of the questionnaire for use at the department and hospital levels using generalizability theory. 22924 adults hospitalized for ≥24 hours between 1 January 2013 and 31 December 2014 in 23 Dutch hospitals (515 department evaluations). CQI Inpatient Hospital Care questionnaire. CFA results showed a good fit on individual level (CFI=0.96, TLI=0.95, RMSEA=0.04), which was comparable between specialties. When scores were aggregated to the department level, the fit was less desirable (CFI=0.83, TLI=0.81, RMSEA=0.06), and there was a significant overlap between communication with doctors and explanation of treatment subscales. Departments and hospitals explained ≤5% of total variance in subscale scores. In total, 4-8 departments and 50 respondents per department are needed to reliably evaluate subscales rated on a 4-point scale, and 10 departments with 100-150 respondents per department for binary subscales. The CQI Inpatient Hospital Care is a valid and reliable questionnaire to evaluate inpatient experiences in Dutch hospitals provided sufficient sampling is done. Results can facilitate meaningful comparisons and guide quality improvement activities in individual departments and hospitals. © 2017 The Authors Health Expectations Published by John Wiley & Sons Ltd.

  4. A Supersonic Argon/Air Coaxial Jet Experiment for Computational Fluid Dynamics Code Validation

    NASA Technical Reports Server (NTRS)

    Clifton, Chandler W.; Cutler, Andrew D.

    2007-01-01

    A non-reacting experiment is described in which data has been acquired for the validation of CFD codes used to design high-speed air-breathing engines. A coaxial jet-nozzle has been designed to produce pressure-matched exit flows of Mach 1.8 at 1 atm in both a center jet of argon and a coflow jet of air, creating a supersonic, incompressible mixing layer. The flowfield was surveyed using total temperature, gas composition, and Pitot probes. The data set was compared to CFD code predictions made using Vulcan, a structured grid Navier-Stokes code, as well as to data from a previous experiment in which a He-O2 mixture was used instead of argon in the center jet of the same coaxial jet assembly. Comparison of experimental data from the argon flowfield and its computational prediction shows that the CFD produces an accurate solution for most of the measured flowfield. However, the CFD prediction deviates from the experimental data in the region downstream of x/D = 4, underpredicting the mixing-layer growth rate.

  5. Free Radicals and Reactive Intermediates for the SAGE III Ozone Loss and Validation Experiment (SOLVE) Mission

    NASA Technical Reports Server (NTRS)

    Anderson, James G.

    2001-01-01

    This grant provided partial support for participation in the SAGE III Ozone Loss and Validation Experiment. The NASA-sponsored SOLVE mission was conducted Jointly with the European Commission-sponsored Third European Stratospheric Experiment on Ozone (THESEO 2000). Researchers examined processes that control ozone amounts at mid to high latitudes during the arctic winter and acquired correlative data needed to validate the Stratospheric Aerosol and Gas Experiment (SAGE) III satellite measurements that are used to quantitatively assess high-latitude ozone loss. The campaign began in September 1999 with intercomparison flights out of NASA Dryden Flight Research Center in Edwards. CA. and continued through March 2000. with midwinter deployments out of Kiruna. Sweden. SOLVE was co-sponsored by the Upper Atmosphere Research Program (UARP). Atmospheric Effects of Aviation Project (AEAP). Atmospheric Chemistry Modeling and Analysis Program (ACMAP). and Earth Observing System (EOS) of NASA's Earth Science Enterprise (ESE) as part of the validation program for the SAGE III instrument.

  6. Description of the CERES Ocean Validation Experiment (COVE), A Dedicated EOS Validation Test Site

    NASA Astrophysics Data System (ADS)

    Rutledge, K.; Charlock, T.; Smith, B.; Jin, Z.; Rose, F.; Denn, F.; Rutan, D.; Haeffelin, M.; Su, W.; Xhang, T.; Jay, M.

    2001-12-01

    A unique test site located in the mid-Atlantic coastal marine waters has been used by several EOS projects for validation measurements. A common theme across these projects is the need for a stable measurement site within the marine environment for long-term, high quality radiation measurements. The site was initiated by NASA's Clouds and the Earths Radiant Energy System (CERES) project. One of CERES's challenging goals is to provide upwelling and downwelling shortwave fluxes at several pressure altitudes within the atmosphere and at the surface. Operationally the radiative transfer model of Fu and Liou (1996, 1998), the CERES instrument measured radiances and various other EOS platform data are being used to accomplish this goal. We present here, a component of the CERES/EOS validation effort that is focused to verify and optimize the prediction algorithms for radiation parameters associated with the marine coastal and oceanic surface types of the planet. For this validation work, the CERES Ocean Validation Experiment (COVE) was developed to provide detailed high-frequency and long-duration measurements for radiation and their associated dependent variables. The CERES validations also include analytical efforts which will not be described here (but see Charlock et.al, Su et.al., Smith et.al-Fall 2001 AGU Meeting) The COVE activity is based on a rigid ocean platform which is located approximately twenty kilometers off of the coast of Virginia Beach, Virginia. The once-manned US Coast Guard facility rises 35 meters from the ocean surface allowing the radiation instruments to be well above the splash zone. The depth of the sea is eleven meters at the site. A power and communications system has been installed for present and future requirements. Scientific measurements at the site have primarily been developed within the framework of established national and international monitoring programs. These include the Baseline Surface Radiation Network of the World

  7. Towards program theory validation: Crowdsourcing the qualitative analysis of participant experiences.

    PubMed

    Harman, Elena; Azzam, Tarek

    2018-02-01

    This exploratory study examines a novel tool for validating program theory through crowdsourced qualitative analysis. It combines a quantitative pattern matching framework traditionally used in theory-driven evaluation with crowdsourcing to analyze qualitative interview data. A sample of crowdsourced participants are asked to read an interview transcript and identify whether program theory components (Activities and Outcomes) are discussed and to highlight the most relevant passage about that component. The findings indicate that using crowdsourcing to analyze qualitative data can differentiate between program theory components that are supported by a participant's experience and those that are not. This approach expands the range of tools available to validate program theory using qualitative data, thus strengthening the theory-driven approach. Copyright © 2017 Elsevier Ltd. All rights reserved.

  8. EVLncRNAs: a manually curated database for long non-coding RNAs validated by low-throughput experiments.

    PubMed

    Zhou, Bailing; Zhao, Huiying; Yu, Jiafeng; Guo, Chengang; Dou, Xianghua; Song, Feng; Hu, Guodong; Cao, Zanxia; Qu, Yuanxu; Yang, Yuedong; Zhou, Yaoqi; Wang, Jihua

    2018-01-04

    Long non-coding RNAs (lncRNAs) play important functional roles in various biological processes. Early databases were utilized to deposit all lncRNA candidates produced by high-throughput experimental and/or computational techniques to facilitate classification, assessment and validation. As more lncRNAs are validated by low-throughput experiments, several databases were established for experimentally validated lncRNAs. However, these databases are small in scale (with a few hundreds of lncRNAs only) and specific in their focuses (plants, diseases or interactions). Thus, it is highly desirable to have a comprehensive dataset for experimentally validated lncRNAs as a central repository for all of their structures, functions and phenotypes. Here, we established EVLncRNAs by curating lncRNAs validated by low-throughput experiments (up to 1 May 2016) and integrating specific databases (lncRNAdb, LncRANDisease, Lnc2Cancer and PLNIncRBase) with additional functional and disease-specific information not covered previously. The current version of EVLncRNAs contains 1543 lncRNAs from 77 species that is 2.9 times larger than the current largest database for experimentally validated lncRNAs. Seventy-four percent lncRNA entries are partially or completely new, comparing to all existing experimentally validated databases. The established database allows users to browse, search and download as well as to submit experimentally validated lncRNAs. The database is available at http://biophy.dzu.edu.cn/EVLncRNAs. © The Author(s) 2017. Published by Oxford University Press on behalf of Nucleic Acids Research.

  9. EVLncRNAs: a manually curated database for long non-coding RNAs validated by low-throughput experiments

    PubMed Central

    Zhao, Huiying; Yu, Jiafeng; Guo, Chengang; Dou, Xianghua; Song, Feng; Hu, Guodong; Cao, Zanxia; Qu, Yuanxu

    2018-01-01

    Abstract Long non-coding RNAs (lncRNAs) play important functional roles in various biological processes. Early databases were utilized to deposit all lncRNA candidates produced by high-throughput experimental and/or computational techniques to facilitate classification, assessment and validation. As more lncRNAs are validated by low-throughput experiments, several databases were established for experimentally validated lncRNAs. However, these databases are small in scale (with a few hundreds of lncRNAs only) and specific in their focuses (plants, diseases or interactions). Thus, it is highly desirable to have a comprehensive dataset for experimentally validated lncRNAs as a central repository for all of their structures, functions and phenotypes. Here, we established EVLncRNAs by curating lncRNAs validated by low-throughput experiments (up to 1 May 2016) and integrating specific databases (lncRNAdb, LncRANDisease, Lnc2Cancer and PLNIncRBase) with additional functional and disease-specific information not covered previously. The current version of EVLncRNAs contains 1543 lncRNAs from 77 species that is 2.9 times larger than the current largest database for experimentally validated lncRNAs. Seventy-four percent lncRNA entries are partially or completely new, comparing to all existing experimentally validated databases. The established database allows users to browse, search and download as well as to submit experimentally validated lncRNAs. The database is available at http://biophy.dzu.edu.cn/EVLncRNAs. PMID:28985416

  10. The earth radiation budget experiment: Early validation results

    NASA Astrophysics Data System (ADS)

    Smith, G. Louis; Barkstrom, Bruce R.; Harrison, Edwin F.

    The Earth Radiation Budget Experiment (ERBE) consists of radiometers on a dedicated spacecraft in a 57° inclination orbit, which has a precessional period of 2 months, and on two NOAA operational meteorological spacecraft in near polar orbits. The radiometers include scanning narrow field-of-view (FOV) and nadir-looking wide and medium FOV radiometers covering the ranges 0.2 to 5 μm and 5 to 50 μm and a solar monitoring channel. This paper describes the validation procedures and preliminary results. Each of the radiometer channels underwent extensive ground calibration, and the instrument packages include in-flight calibration facilities which, to date, show negligible changes of the instruments in orbit, except for gradual degradation of the suprasil dome of the shortwave wide FOV (about 4% per year). Measurements of the solar constant by the solar monitors, wide FOV, and medium FOV radiometers of two spacecraft agree to a fraction of a percent. Intercomparisons of the wide and medium FOV radiometers with the scanning radiometers show agreement of 1 to 4%. The multiple ERBE satellites are acquiring the first global measurements of regional scale diurnal variations in the Earth's radiation budget. These diurnal variations are verified by comparison with high temporal resolution geostationary satellite data. Other principal investigators of the ERBE Science Team are: R. Cess, SUNY, Stoneybrook; J. Coakley, NCAR; C. Duncan, M. King and A Mecherikunnel, Goddard Space Flight Center, NASA; A. Gruber and A.J. Miller, NOAA; D. Hartmann, U. Washington; F.B. House, Drexel U.; F.O. Huck, Langley Research Center, NASA; G. Hunt, Imperial College, London U.; R. Kandel and A. Berroir, Laboratory of Dynamic Meteorology, Ecole Polytechique; V. Ramanathan, U. Chicago; E. Raschke, U. of Cologne; W.L. Smith, U. of Wisconsin and T.H. Vonder Haar, Colorado State U.

  11. Monitoring Building Deformation with InSAR: Experiments and Validation.

    PubMed

    Yang, Kui; Yan, Li; Huang, Guoman; Chen, Chu; Wu, Zhengpeng

    2016-12-20

    Synthetic Aperture Radar Interferometry (InSAR) techniques are increasingly applied for monitoring land subsidence. The advantages of InSAR include high accuracy and the ability to cover large areas; nevertheless, research validating the use of InSAR on building deformation is limited. In this paper, we test the monitoring capability of the InSAR in experiments using two landmark buildings; the Bohai Building and the China Theater, located in Tianjin, China. They were selected as real examples to compare InSAR and leveling approaches for building deformation. Ten TerraSAR-X images spanning half a year were used in Permanent Scatterer InSAR processing. These extracted InSAR results were processed considering the diversity in both direction and spatial distribution, and were compared with true leveling values in both Ordinary Least Squares (OLS) regression and measurement of error analyses. The detailed experimental results for the Bohai Building and the China Theater showed a high correlation between InSAR results and the leveling values. At the same time, the two Root Mean Square Error (RMSE) indexes had values of approximately 1 mm. These analyses show that a millimeter level of accuracy can be achieved by means of InSAR technique when measuring building deformation. We discuss the differences in accuracy between OLS regression and measurement of error analyses, and compare the accuracy index of leveling in order to propose InSAR accuracy levels appropriate for monitoring buildings deformation. After assessing the advantages and limitations of InSAR techniques in monitoring buildings, further applications are evaluated.

  12. Monitoring Building Deformation with InSAR: Experiments and Validation

    PubMed Central

    Yang, Kui; Yan, Li; Huang, Guoman; Chen, Chu; Wu, Zhengpeng

    2016-01-01

    Synthetic Aperture Radar Interferometry (InSAR) techniques are increasingly applied for monitoring land subsidence. The advantages of InSAR include high accuracy and the ability to cover large areas; nevertheless, research validating the use of InSAR on building deformation is limited. In this paper, we test the monitoring capability of the InSAR in experiments using two landmark buildings; the Bohai Building and the China Theater, located in Tianjin, China. They were selected as real examples to compare InSAR and leveling approaches for building deformation. Ten TerraSAR-X images spanning half a year were used in Permanent Scatterer InSAR processing. These extracted InSAR results were processed considering the diversity in both direction and spatial distribution, and were compared with true leveling values in both Ordinary Least Squares (OLS) regression and measurement of error analyses. The detailed experimental results for the Bohai Building and the China Theater showed a high correlation between InSAR results and the leveling values. At the same time, the two Root Mean Square Error (RMSE) indexes had values of approximately 1 mm. These analyses show that a millimeter level of accuracy can be achieved by means of InSAR technique when measuring building deformation. We discuss the differences in accuracy between OLS regression and measurement of error analyses, and compare the accuracy index of leveling in order to propose InSAR accuracy levels appropriate for monitoring buildings deformation. After assessing the advantages and limitations of InSAR techniques in monitoring buildings, further applications are evaluated. PMID:27999403

  13. Validation of design procedure and performance modeling of a heat and fluid transport field experiment in the unsaturated zone

    NASA Astrophysics Data System (ADS)

    Nir, A.; Doughty, C.; Tsang, C. F.

    Validation methods which developed in the context of deterministic concepts of past generations often cannot be directly applied to environmental problems, which may be characterized by limited reproducibility of results and highly complex models. Instead, validation is interpreted here as a series of activities, including both theoretical and experimental tests, designed to enhance our confidence in the capability of a proposed model to describe some aspect of reality. We examine the validation process applied to a project concerned with heat and fluid transport in porous media, in which mathematical modeling, simulation, and results of field experiments are evaluated in order to determine the feasibility of a system for seasonal thermal energy storage in shallow unsaturated soils. Technical details of the field experiments are not included, but appear in previous publications. Validation activities are divided into three stages. The first stage, carried out prior to the field experiments, is concerned with modeling the relevant physical processes, optimization of the heat-exchanger configuration and the shape of the storage volume, and multi-year simulation. Subjects requiring further theoretical and experimental study are identified at this stage. The second stage encompasses the planning and evaluation of the initial field experiment. Simulations are made to determine the experimental time scale and optimal sensor locations. Soil thermal parameters and temperature boundary conditions are estimated using an inverse method. Then results of the experiment are compared with model predictions using different parameter values and modeling approximations. In the third stage, results of an experiment performed under different boundary conditions are compared to predictions made by the models developed in the second stage. Various aspects of this theoretical and experimental field study are described as examples of the verification and validation procedure. There is no

  14. Validation experiments to determine radiation partitioning of heat flux to an object in a fully turbulent fire.

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Ricks, Allen; Blanchat, Thomas K.; Jernigan, Dann A.

    2006-06-01

    It is necessary to improve understanding and develop validation data of the heat flux incident to an object located within the fire plume for the validation of SIERRA/ FUEGO/SYRINX fire and SIERRA/CALORE. One key aspect of the validation data sets is the determination of the relative contribution of the radiative and convective heat fluxes. To meet this objective, a cylindrical calorimeter with sufficient instrumentation to measure total and radiative heat flux had been designed and fabricated. This calorimeter will be tested both in the controlled radiative environment of the Penlight facility and in a fire environment in the FLAME/Radiant Heatmore » (FRH) facility. Validation experiments are specifically designed for direct comparison with the computational predictions. Making meaningful comparisons between the computational and experimental results requires careful characterization and control of the experimental features or parameters used as inputs into the computational model. Validation experiments must be designed to capture the essential physical phenomena, including all relevant initial and boundary conditions. A significant question of interest to modeling heat flux incident to an object in or near a fire is the contribution of the radiation and convection modes of heat transfer. The series of experiments documented in this test plan is designed to provide data on the radiation partitioning, defined as the fraction of the total heat flux that is due to radiation.« less

  15. Validation of the Italian version of the dissociative experience scale for adolescents and young adults.

    PubMed

    De Pasquale, Concetta; Sciacca, Federica; Hichy, Zira

    2016-01-01

    The Dissociative Experience Scale for adolescent (A-DES), a 30-item, multidimensional, self-administered questionnaire, was validated using a large sample of American young people sample. We reported the linguistic validation process and the metric validity of the Italian version of A-DES in the Italy. A set of questionnaires was provided to a total of 633 participants from March 2015 to April 2016. The participants consisted of 282 boys and 351 girls, and their average age was between 18 and 24 years old. The translation process consisted of two consecutive steps: forward-backward translation and acceptability testing. The psychometric testing was applied to Italian students who were recruited from the Italian Public Schools and Universities in Sicily. Informed consent was obtained from all participants at the research. All individuals completed the A-DES. Reliability and validity were tested. The translated version was validated on a total of 633 Italian students. The reliability of A-DES total is .926. It is composed by 4 subscales: Dissociative amnesia, Absorption and imaginative involvement, Depersonalization and derealization, and Passive influence. The reliability of each subscale is: .756 for dissociative amnesia, .659 for absorption and imaginative involvement, .850 for depersonalization and derealization, and .743 for passive influence. The Italian version of the A-DES constitutes a useful instrument to measure dissociative experience in adolescents and young adults in Italy.

  16. Validation of the Land-Surface Energy Budget and Planetary Boundary Layer for Several Intensive field Experiments

    NASA Technical Reports Server (NTRS)

    Bosilovich, Michael G.; Schubert, Siegfried; Molod, Andrea; Houser, Paul R.

    1999-01-01

    Land-surface processes in a data assimilation system influence the lower troposphere and must be properly represented. With the recent incorporation of the Mosaic Land-surface Model (LSM) into the GEOS Data Assimilation System (DAS), the detailed land-surface processes require strict validation. While global data sources can identify large-scale systematic biases at the monthly timescale, the diurnal cycle is difficult to validate. Moreover, global data sets rarely include variables such as evaporation, sensible heat and soil water. Intensive field experiments, on the other hand, can provide high temporal resolution energy budget and vertical profile data for sufficiently long periods, without global coverage. Here, we evaluate the GEOS DAS against several intensive field experiments. The field experiments are First ISLSCP Field Experiment (FIFE, Kansas, summer 1987), Cabauw (as used in PILPS, Netherlands, summer 1987), Atmospheric Radiation Measurement (ARM, Southern Great Plains, winter and summer 1998) and the Surface Heat Budget of the Arctic Ocean (SHEBA, Arctic ice sheet, winter and summer 1998). The sites provide complete surface energy budget data for periods of at least one year, and some periods of vertical profiles. This comparison provides a detailed validation of the Mosaic LSM within the GEOS DAS for a variety of climatologic and geographic conditions.

  17. STS-42 closeup view shows SE 81-09 Convection in Zero Gravity experiment

    NASA Image and Video Library

    1992-01-30

    STS-42 closeup view shows Student Experiment 81-09 (SE 81-09), Convection in Zero Gravity experiment, with radial pattern caused by convection induced by heating an oil and aluminum powder mixture in the weightlessness of space. While the STS-42 crewmembers activated the Shuttle Student Involvement Program (SSIP) experiment on Discovery's, Orbiter Vehicle (OV) 103's, middeck, Scott Thomas, the student who designed the experiment, was able to observe the procedures via downlinked television (TV) in JSC's Mission Control Center (MCC). Thomas, now a physics doctoral student at the University of Texas, came up with the experiment while he participated in the SSIP as a student at Richland High School in Johnstown, Pennsylvia.

  18. TRIMS: Validating T2 Molecular Effects for Neutrino Mass Experiments

    NASA Astrophysics Data System (ADS)

    Lin, Ying-Ting; Trims Collaboration

    2017-09-01

    The Tritium Recoil-Ion Mass Spectrometer (TRIMS) experiment examines the branching ratio of the molecular tritium (T2) beta decay to the bound state (3HeT+). Measuring this branching ratio helps to validate the current molecular final-state theory applied in neutrino mass experiments such as KATRIN and Project 8. TRIMS consists of a magnet-guided time-of-flight mass spectrometer with a detector located on each end. By measuring the kinetic energy and time-of-flight difference of the ions and beta particles reaching the detectors, we will be able to distinguish molecular ions from atomic ones and hence derive the ratio in question. We will give an update on the apparatus, simulation software, and analysis tools, including efforts to improve the resolution of our detectors and to characterize the stability and uniformity of our field sources. We will also share our commissioning results and prospects for physics data. The TRIMS experiment is supported by U.S. Department of Energy Office of Science, Office of Nuclear Physics, Award Number DE-FG02-97ER41020.

  19. Development and validation of the Measure of Indigenous Racism Experiences (MIRE)

    PubMed Central

    Paradies, Yin C; Cunningham, Joan

    2008-01-01

    Background In recent decades there has been increasing evidence of a relationship between self-reported racism and health. Although a plethora of instruments to measure racism have been developed, very few have been described conceptually or psychometrically Furthermore, this research field has been limited by a dearth of instruments that examine reactions/responses to racism and by a restricted focus on African American populations. Methods In response to these limitations, the 31-item Measure of Indigenous Racism Experiences (MIRE) was developed to assess self-reported racism for Indigenous Australians. This paper describes the development of the MIRE together with an opportunistic examination of its content, construct and convergent validity in a population health study involving 312 Indigenous Australians. Results Focus group research supported the content validity of the MIRE, and inter-item/scale correlations suggested good construct validity. A good fit with a priori conceptual dimensions was demonstrated in factor analysis, and convergence with a separate item on discrimination was satisfactory. Conclusion The MIRE has considerable utility as an instrument that can assess multiple facets of racism together with responses/reactions to racism among indigenous populations and, potentially, among other ethnic/racial groups. PMID:18426602

  20. Validity of Adult Retrospective Reports of Adverse Childhood Experiences: Review of the Evidence

    ERIC Educational Resources Information Center

    Hardt, Jochen; Rutter, Michael

    2004-01-01

    Background: Influential studies have cast doubt on the validity of retrospective reports by adults of their own adverse experiences in childhood. Accordingly, many researchers view retrospective reports with scepticism. Method: A computer-based search, supplemented by hand searches, was used to identify studies reported between 1980 and 2001 in…

  1. Directed Design of Experiments for Validating Probability of Detection Capability of a Testing System

    NASA Technical Reports Server (NTRS)

    Generazio, Edward R. (Inventor)

    2012-01-01

    A method of validating a probability of detection (POD) testing system using directed design of experiments (DOE) includes recording an input data set of observed hit and miss or analog data for sample components as a function of size of a flaw in the components. The method also includes processing the input data set to generate an output data set having an optimal class width, assigning a case number to the output data set, and generating validation instructions based on the assigned case number. An apparatus includes a host machine for receiving the input data set from the testing system and an algorithm for executing DOE to validate the test system. The algorithm applies DOE to the input data set to determine a data set having an optimal class width, assigns a case number to that data set, and generates validation instructions based on the case number.

  2. A Rasch scaling validation of a 'core' near-death experience.

    PubMed

    Lange, Rense; Greyson, Bruce; Houran, James

    2004-05-01

    For those with true near-death experiences (NDEs), Greyson's (1983, 1990) NDE Scale satisfactorily fits the Rasch rating scale model, thus yielding a unidimensional measure with interval-level scaling properties. With increasing intensity, NDEs reflect peace, joy and harmony, followed by insight and mystical or religious experiences, while the most intense NDEs involve an awareness of things occurring in a different place or time. The semantics of this variable are invariant across True-NDErs' gender, current age, age at time of NDE, and latency and intensity of the NDE, thus identifying NDEs as 'core' experiences whose meaning is unaffected by external variables, regardless of variations in NDEs' intensity. Significant qualitative and quantitative differences were observed between True-NDErs and other respondent groups, mostly revolving around the differential emphasis on paranormal/mystical/religious experiences vs. standard reactions to threat. The findings further suggest that False-Positive respondents reinterpret other profound psychological states as NDEs. Accordingly, the Rasch validation of the typology proposed by Greyson (1983) also provides new insights into previous research, including the possibility of embellishment over time (as indicated by the finding of positive, as well as negative, latency effects) and the potential roles of religious affiliation and religiosity (as indicated by the qualitative differences surrounding paranormal/mystical/religious issues).

  3. Design of experiments in medical physics: Application to the AAA beam model validation.

    PubMed

    Dufreneix, S; Legrand, C; Di Bartolo, C; Bremaud, M; Mesgouez, J; Tiplica, T; Autret, D

    2017-09-01

    The purpose of this study is to evaluate the usefulness of the design of experiments in the analysis of multiparametric problems related to the quality assurance in radiotherapy. The main motivation is to use this statistical method to optimize the quality assurance processes in the validation of beam models. Considering the Varian Eclipse system, eight parameters with several levels were selected: energy, MLC, depth, X, Y 1 and Y 2 jaw dimensions, wedge and wedge jaw. A Taguchi table was used to define 72 validation tests. Measurements were conducted in water using a CC04 on a TrueBeam STx, a TrueBeam Tx, a Trilogy and a 2300IX accelerator matched by the vendor. Dose was computed using the AAA algorithm. The same raw data was used for all accelerators during the beam modelling. The mean difference between computed and measured doses was 0.1±0.5% for all beams and all accelerators with a maximum difference of 2.4% (under the 3% tolerance level). For all beams, the measured doses were within 0.6% for all accelerators. The energy was found to be an influencing parameter but the deviations observed were smaller than 1% and not considered clinically significant. Designs of experiment can help define the optimal measurement set to validate a beam model. The proposed method can be used to identify the prognostic factors of dose accuracy. The beam models were validated for the 4 accelerators which were found dosimetrically equivalent even though the accelerator characteristics differ. Copyright © 2017 Associazione Italiana di Fisica Medica. Published by Elsevier Ltd. All rights reserved.

  4. Validation and Scaling of Soil Moisture in a Semi-Arid Environment: SMAP Validation Experiment 2015 (SMAPVEX15)

    NASA Technical Reports Server (NTRS)

    Colliander, Andreas; Cosh, Michael H.; Misra, Sidharth; Jackson, Thomas J.; Crow, Wade T.; Chan, Steven; Bindlish, Rajat; Chae, Chun; Holifield Collins, Chandra; Yueh, Simon H.

    2017-01-01

    The NASA SMAP (Soil Moisture Active Passive) mission conducted the SMAP Validation Experiment 2015 (SMAPVEX15) in order to support the calibration and validation activities of SMAP soil moisture data products. The main goals of the experiment were to address issues regarding the spatial disaggregation methodologies for improvement of soil moisture products and validation of the in situ measurement upscaling techniques. To support these objectives high-resolution soil moisture maps were acquired with the airborne PALS (Passive Active L-band Sensor) instrument over an area in southeast Arizona that includes the Walnut Gulch Experimental Watershed (WGEW), and intensive ground sampling was carried out to augment the permanent in situ instrumentation. The objective of the paper was to establish the correspondence and relationship between the highly heterogeneous spatial distribution of soil moisture on the ground and the coarse resolution radiometer-based soil moisture retrievals of SMAP. The high-resolution mapping conducted with PALS provided the required connection between the in situ measurements and SMAP retrievals. The in situ measurements were used to validate the PALS soil moisture acquired at 1-km resolution. Based on the information from a dense network of rain gauges in the study area, the in situ soil moisture measurements did not capture all the precipitation events accurately. That is, the PALS and SMAP soil moisture estimates responded to precipitation events detected by rain gauges, which were in some cases not detected by the in situ soil moisture sensors. It was also concluded that the spatial distribution of the soil moisture resulted from the relatively small spatial extents of the typical convective storms in this region was not completely captured with the in situ stations. After removing those cases (approximately10 of the observations) the following metrics were obtained: RMSD (root mean square difference) of0.016m3m3 and correlation of 0.83. The

  5. Development and initial validation of the assessment of caregiver experience with neuromuscular disease.

    PubMed

    Matsumoto, Hiroko; Clayton-Krasinski, Debora A; Klinge, Stephen A; Gomez, Jaime A; Booker, Whitney A; Hyman, Joshua E; Roye, David P; Vitale, Michael G

    2011-01-01

    Orthopaedic intervention can have a wide range of functional and psychosocial effects on children with neuromuscular disease (NMD). In the multihandicapped child (Gross Motor Classification System IV/V), functional status, pain, psychosocial function, and health-related quality of life also have effects on the families of these child. The purpose of this study is to report the development and initial validation of an outcomes instrument specifically designed to assess the caregiver impact experienced by parents raising severely affected NMD children: the Assessment of Caregiver Experience with Neuromuscular Disease (ACEND). In the first part of this prospective study, 61 children with NMD and their parents were administered a range of earlier validated pediatric health measures. A framework technique was used to select the most appropriate and relevant subset of questions from this large set. Sensitivity analyses guided the development of a master question list measuring caregiver impact, excluding items with low relevance, and modifying unclear questions. In the second part of the study, the ACEND was administered to the caregivers of 46 children with moderate-to-severe NMD. Statistical analyses were conducted to determine validity of the instrument. The resulting ACEND instrument included 2 domains, 7 subdomains, and 41 items. Domain 1, examining physical impact, includes 4 subdomains: feeding/grooming/dressing (6 items), sitting/play (5 items), transfers (5 items), and mobility (7 items). Domain 2, which examines general caregiver impact, included 3 subdomains: time (4 items), emotion (9 items), and finance (5 items). Mean overall relevance rating was 6.21 ± 0.37 and clarity rating was 6.68 ± 0.52 (scale 0 to 7). Multiple floor effects in patients with GMFCS V and ceiling effects in patients with GMFCS III were identified almost exclusively in motor-based items. Virtually no floor or ceiling effects were identified in the time, emotion or finance domains

  6. [Validation of a Japanese version of the Experience in Close Relationship- Relationship Structure].

    PubMed

    Komura, Kentaro; Murakami, Tatsuya; Toda, Koji

    2016-08-01

    The purpose of this study was to translate the Experience of Close Relationship-Relationship Structure (ECRRS) and evaluate its validity. In study 1 (N = 982), evidence based internal structure (factor structure, internal consistency, and correlation among sub-scales) and evidence based relations to other variables (depression, reassurance seeking and self-esteem) were confirmed. In study 2 (N = 563), evidence based on internal structure was reconfirmed, and evidence based relations to other variables (IWMS, RQ, and ECR-GO) were confirmed. In study 3 (N = 342), evidence based internal structure (test-retest reliability) was confirmed. Based on these results, we concluded that ECR-RS was valid for measuring adult attachment style.

  7. Libet's experiment: Questioning the validity of measuring the urge to move.

    PubMed

    Dominik, Tomáš; Dostál, Daniel; Zielina, Martin; Šmahaj, Jan; Sedláčková, Zuzana; Procházka, Roman

    2017-03-01

    The time of subjectively registered urge to move (W) constituted the central point of most Libet-style experiments. It is therefore crucial to verify the W validity. Our experiment was based on the assumption that the W time is inferred, rather than introspectively perceived. We used the rotating spot method to gather the W reports together with the reports of the subjective timing of actual movement (M). The subjects were assigned the tasks in two different orders. When measured as first in the respective session, no significant difference between W and M values was found, which suggests that uninformed subjects tend to confuse W for M reports. Moreover, we found that W values measured after the M task were significantly earlier than W values measured before M. This phenomenon suggests that the apparent difference between W and M values is in fact caused by the subjects' previous experience with M measurements. Copyright © 2017 Elsevier Inc. All rights reserved.

  8. SCALE TSUNAMI Analysis of Critical Experiments for Validation of 233U Systems

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Mueller, Don; Rearden, Bradley T

    2009-01-01

    Oak Ridge National Laboratory (ORNL) staff used the SCALE TSUNAMI tools to provide a demonstration evaluation of critical experiments considered for use in validation of current and anticipated operations involving {sup 233}U at the Radiochemical Development Facility (RDF). This work was reported in ORNL/TM-2008/196 issued in January 2009. This paper presents the analysis of two representative safety analysis models provided by RDF staff.

  9. An intercomparison of a large ensemble of statistical downscaling methods for Europe: Overall results from the VALUE perfect predictor cross-validation experiment

    NASA Astrophysics Data System (ADS)

    Gutiérrez, Jose Manuel; Maraun, Douglas; Widmann, Martin; Huth, Radan; Hertig, Elke; Benestad, Rasmus; Roessler, Ole; Wibig, Joanna; Wilcke, Renate; Kotlarski, Sven

    2016-04-01

    VALUE is an open European network to validate and compare downscaling methods for climate change research (http://www.value-cost.eu). A key deliverable of VALUE is the development of a systematic validation framework to enable the assessment and comparison of both dynamical and statistical downscaling methods. This framework is based on a user-focused validation tree, guiding the selection of relevant validation indices and performance measures for different aspects of the validation (marginal, temporal, spatial, multi-variable). Moreover, several experiments have been designed to isolate specific points in the downscaling procedure where problems may occur (assessment of intrinsic performance, effect of errors inherited from the global models, effect of non-stationarity, etc.). The list of downscaling experiments includes 1) cross-validation with perfect predictors, 2) GCM predictors -aligned with EURO-CORDEX experiment- and 3) pseudo reality predictors (see Maraun et al. 2015, Earth's Future, 3, doi:10.1002/2014EF000259, for more details). The results of these experiments are gathered, validated and publicly distributed through the VALUE validation portal, allowing for a comprehensive community-open downscaling intercomparison study. In this contribution we describe the overall results from Experiment 1), consisting of a European wide 5-fold cross-validation (with consecutive 6-year periods from 1979 to 2008) using predictors from ERA-Interim to downscale precipitation and temperatures (minimum and maximum) over a set of 86 ECA&D stations representative of the main geographical and climatic regions in Europe. As a result of the open call for contribution to this experiment (closed in Dec. 2015), over 40 methods representative of the main approaches (MOS and Perfect Prognosis, PP) and techniques (linear scaling, quantile mapping, analogs, weather typing, linear and generalized regression, weather generators, etc.) were submitted, including information both data

  10. Recidivism in female offenders: PCL-R lifestyle factor and VRAG show predictive validity in a German sample.

    PubMed

    Eisenbarth, Hedwig; Osterheider, Michael; Nedopil, Norbert; Stadtland, Cornelis

    2012-01-01

    A clear and structured approach to evidence-based and gender-specific risk assessment of violence in female offenders is high on political and mental health agendas. However, most data on the factors involved in risk-assessment instruments are based on data of male offenders. The aim of the present study was to validate the use of the Psychopathy Checklist Revised (PCL-R), the HCR-20 and the Violence Risk Appraisal Guide (VRAG) for the prediction of recidivism in German female offenders. This study is part of the Munich Prognosis Project (MPP). It focuses on a subsample of female delinquents (n = 80) who had been referred for forensic-psychiatric evaluation prior to sentencing. The mean time at risk was 8 years (SD = 5 years; range: 1-18 years). During this time, 31% (n = 25) of the female offenders were reconvicted, 5% (n = 4) for violent and 26% (n = 21) for non-violent re-offenses. The predictive validity of the PCL-R for general recidivism was calculated. Analysis with receiver-operating characteristics revealed that the PCL-R total score, the PCL-R antisocial lifestyle factor, the PCL-R lifestyle factor and the PCL-R impulsive and irresponsible behavioral style factor had a moderate predictive validity for general recidivism (area under the curve, AUC = 0.66, p = 0.02). The VRAG has also demonstrated predictive validity (AUC = 0.72, p = 0.02), whereas the HCR-20 showed no predictive validity. These results appear to provide the first evidence that the PCL-R total score and the antisocial lifestyle factor are predictive for general female recidivism, as has been shown consistently for male recidivists. The implications of these findings for crime prevention, prognosis in women, and future research are discussed. Copyright © 2012 John Wiley & Sons, Ltd.

  11. The Experiences in Close Relationship Scale (ECR)-short form: reliability, validity, and factor structure.

    PubMed

    Wei, Meifen; Russell, Daniel W; Mallinckrodt, Brent; Vogel, David L

    2007-04-01

    We developed a 12-item, short form of the Experiences in Close Relationship Scale (ECR; Brennan, Clark, & Shaver, 1998) across 6 studies. In Study 1, we examined the reliability and factor structure of the measure. In Studies 2 and 3, we cross-validated the reliability, factor structure, and validity of the short form measure; whereas in Study 4, we examined test-retest reliability over a 1-month period. In Studies 5 and 6, we further assessed the reliability, factor structure, and validity of the short version of the ECR when administered as a stand-alone instrument. Confirmatory factor analyses indicated that 2 factors, labeled Anxiety and Avoidance, provided a good fit to the data after removing the influence of response sets. We found validity to be equivalent for the short and the original versions of the ECR across studies. Finally, the results were comparable when we embedded the short form within the original version of the ECR and when we administered it as a stand-alone measure.

  12. An Examination and Validation of an Adapted Youth Experience Scale for University Sport

    ERIC Educational Resources Information Center

    Rathwell, Scott; Young, Bradley W.

    2016-01-01

    Limited tools assess positive development through university sport. Such a tool was validated in this investigation using two independent samples of Canadian university athletes. In Study 1, 605 athletes completed 99 survey items drawn from the Youth Experience Scale (YES 2.0), and separate a priori measurement models were evaluated (i.e., 99…

  13. Estimation of Uncertainties for a Supersonic Retro-Propulsion Model Validation Experiment in a Wind Tunnel

    NASA Technical Reports Server (NTRS)

    Rhode, Matthew N.; Oberkampf, William L.

    2012-01-01

    A high-quality model validation experiment was performed in the NASA Langley Research Center Unitary Plan Wind Tunnel to assess the predictive accuracy of computational fluid dynamics (CFD) models for a blunt-body supersonic retro-propulsion configuration at Mach numbers from 2.4 to 4.6. Static and fluctuating surface pressure data were acquired on a 5-inch-diameter test article with a forebody composed of a spherically-blunted, 70-degree half-angle cone and a cylindrical aft body. One non-powered configuration with a smooth outer mold line was tested as well as three different powered, forward-firing nozzle configurations: a centerline nozzle, three nozzles equally spaced around the forebody, and a combination with all four nozzles. A key objective of the experiment was the determination of experimental uncertainties from a range of sources such as random measurement error, flowfield non-uniformity, and model/instrumentation asymmetries. This paper discusses the design of the experiment towards capturing these uncertainties for the baseline non-powered configuration, the methodology utilized in quantifying the various sources of uncertainty, and examples of the uncertainties applied to non-powered and powered experimental results. The analysis showed that flowfield nonuniformity was the dominant contributor to the overall uncertainty a finding in agreement with other experiments that have quantified various sources of uncertainty.

  14. A novel cell culture model as a tool for forensic biology experiments and validations.

    PubMed

    Feine, Ilan; Shpitzen, Moshe; Roth, Jonathan; Gafny, Ron

    2016-09-01

    To improve and advance DNA forensic casework investigation outcomes, extensive field and laboratory experiments are carried out in a broad range of relevant branches, such as touch and trace DNA, secondary DNA transfer and contamination confinement. Moreover, the development of new forensic tools, for example new sampling appliances, by commercial companies requires ongoing validation and assessment by forensic scientists. A frequent challenge in these kinds of experiments and validations is the lack of a stable, reproducible and flexible biological reference material. As a possible solution, we present here a cell culture model based on skin-derived human dermal fibroblasts. Cultured cells were harvested, quantified and dried on glass slides. These slides were used in adhesive tape-lifting experiments and tests of DNA crossover confinement by UV irradiation. The use of this model enabled a simple and concise comparison between four adhesive tapes, as well as a straightforward demonstration of the effect of UV irradiation intensities on DNA quantity and degradation. In conclusion, we believe this model has great potential to serve as an efficient research tool in forensic biology. Copyright © 2016 Elsevier Ireland Ltd. All rights reserved.

  15. NASA's Rodent Research Project: Validation of Capabilities for Conducting Long Duration Experiments in Space

    NASA Technical Reports Server (NTRS)

    Choi, Sungshin Y.; Cole, Nicolas; Reyes, America; Lai, San-Huei; Klotz, Rebecca; Beegle, Janet E.; Wigley, Cecilia L.; Pletcher, David; Globus, Ruth K.

    2015-01-01

    Research using rodents is an essential tool for advancing biomedical research on Earth and in space. Prior rodent experiments on the Shuttle were limited by the short flight duration. The International Space Station (ISS) provides a new platform for conducting rodent experiments under long duration conditions. Rodent Research (RR)-1 was conducted to validate flight hardware, operations, and science capabilities that were developed at the NASA Ames Research Center. Twenty C57BL6J adult female mice were launched on Sept 21, 2014 in a Dragon Capsule (SpaceX-4), then transferred to the ISS for a total time of 21-22 days (10 commercial mice) or 37 days (10 validation mice). Tissues collected on-orbit were either rapidly frozen or preserved in RNAlater at -80C (n2group) until their return to Earth. Remaining carcasses on-orbit were rapidly frozen for dissection post-flight. The three controls groups at Kennedy Space Center consisted of: Basal mice euthanized at the time of launch, Vivarium controls housed in standard cages, and Ground Controls (GC) housed in flight hardware within an environmental chamber. Upon return to Earth, there were no differences in body weights between Flight (FLT) and GC at the end of the 37 days in space. Liver enzyme activity levels of FLT mice and all control mice were similar in magnitude to those of the samples that were processed under optimal conditions in the laboratory. Liver samples dissected on-orbit yielded high quality RNA (RIN8.99+-0.59, n7). Liver samples dissected post-flight from the intact, frozen FLT carcasses yielded RIN of 7.27 +- 0.52 (n6). Additionally, wet weights of various tissues were measured. Adrenal glands and spleen showed no significant differences in FLT compared to GC although thymus and livers weights were significantly greater in FLT compared to GC. Over 3,000 tissue aliquots collected post-flight from the four groups of mice were deposited into the Ames Life Science Data Archives for future Biospecimen

  16. Calibration of Predictor Models Using Multiple Validation Experiments

    NASA Technical Reports Server (NTRS)

    Crespo, Luis G.; Kenny, Sean P.; Giesy, Daniel P.

    2015-01-01

    This paper presents a framework for calibrating computational models using data from several and possibly dissimilar validation experiments. The offset between model predictions and observations, which might be caused by measurement noise, model-form uncertainty, and numerical error, drives the process by which uncertainty in the models parameters is characterized. The resulting description of uncertainty along with the computational model constitute a predictor model. Two types of predictor models are studied: Interval Predictor Models (IPMs) and Random Predictor Models (RPMs). IPMs use sets to characterize uncertainty, whereas RPMs use random vectors. The propagation of a set through a model makes the response an interval valued function of the state, whereas the propagation of a random vector yields a random process. Optimization-based strategies for calculating both types of predictor models are proposed. Whereas the formulations used to calculate IPMs target solutions leading to the interval value function of minimal spread containing all observations, those for RPMs seek to maximize the models' ability to reproduce the distribution of observations. Regarding RPMs, we choose a structure for the random vector (i.e., the assignment of probability to points in the parameter space) solely dependent on the prediction error. As such, the probabilistic description of uncertainty is not a subjective assignment of belief, nor is it expected to asymptotically converge to a fixed value, but instead it casts the model's ability to reproduce the experimental data. This framework enables evaluating the spread and distribution of the predicted response of target applications depending on the same parameters beyond the validation domain.

  17. Analysis procedures and subjective flight results of a simulator validation and cue fidelity experiment

    NASA Technical Reports Server (NTRS)

    Carr, Peter C.; Mckissick, Burnell T.

    1988-01-01

    A joint experiment to investigate simulator validation and cue fidelity was conducted by the Dryden Flight Research Facility of NASA Ames Research Center (Ames-Dryden) and NASA Langley Research Center. The primary objective was to validate the use of a closed-loop pilot-vehicle mathematical model as an analytical tool for optimizing the tradeoff between simulator fidelity requirements and simulator cost. The validation process includes comparing model predictions with simulation and flight test results to evaluate various hypotheses for differences in motion and visual cues and information transfer. A group of five pilots flew air-to-air tracking maneuvers in the Langley differential maneuvering simulator and visual motion simulator and in an F-14 aircraft at Ames-Dryden. The simulators used motion and visual cueing devices including a g-seat, a helmet loader, wide field-of-view horizon, and a motion base platform.

  18. Validation of space-based polarization measurements by use of a single-scattering approximation, with application to the global ozone monitoring experiment.

    PubMed

    Aben, Ilse; Tanzi, Cristina P; Hartmann, Wouter; Stam, Daphne M; Stammes, Piet

    2003-06-20

    A method is presented for in-flight validation of space-based polarization measurements based on approximation of the direction of polarization of scattered sunlight by the Rayleigh single-scattering value. This approximation is verified by simulations of radiative transfer calculations for various atmospheric conditions. The simulations show locations along an orbit where the scattering geometries are such that the intensities of the parallel and orthogonal polarization components of the light are equal, regardless of the observed atmosphere and surface. The method can be applied to any space-based instrument that measures the polarization of reflected solar light. We successfully applied the method to validate the Global Ozone Monitoring Experiment (GOME) polarization measurements. The error in the GOME's three broadband polarization measurements appears to be approximately 1%.

  19. CFD Validation Experiment of a Mach 2.5 Axisymmetric Shock-Wave/Boundary-Layer Interaction

    NASA Technical Reports Server (NTRS)

    Davis, David O.

    2015-01-01

    Experimental investigations of specific flow phenomena, e.g., Shock Wave Boundary-Layer Interactions (SWBLI), provide great insight to the flow behavior but often lack the necessary details to be useful as CFD validation experiments. Reasons include: 1.Undefined boundary conditions Inconsistent results 2.Undocumented 3D effects (CL only measurements) 3.Lack of uncertainty analysis While there are a number of good subsonic experimental investigations that are sufficiently documented to be considered test cases for CFD and turbulence model validation, the number of supersonic and hypersonic cases is much less. This was highlighted by Settles and Dodsons [1] comprehensive review of available supersonic and hypersonic experimental studies. In all, several hundred studies were considered for their database.Of these, over a hundred were subjected to rigorous acceptance criteria. Based on their criteria, only 19 (12 supersonic, 7 hypersonic) were considered of sufficient quality to be used for validation purposes. Aeschliman and Oberkampf [2] recognized the need to develop a specific methodology for experimental studies intended specifically for validation purposes.

  20. Validity and reliability of CHOICE Health Experience Questionnaire: Thai version.

    PubMed

    Aiyasanon, Nipa; Premasathian, Nalinee; Nimmannit, Akarin; Jetanavanich, Pantip; Sritippayawan, Suchai

    2009-09-01

    Assess the reliability and validity of the Thai translation of the CHOICE Health Experience Questionnaire (CHEQ), which is the English-language questionnaire, developed specifically for End-stage-renal disease (ESRD) patients. The CHEQ comprised of two parts, nine general domains of SF-36 (physical function, role-physical, bodily pain, mental health, role-emotional, social function, vitality, general health, and report transition) and 16 dialysis specific domains of the CHEQ (role-physical, mental health, general health, freedom, travel restriction, cognitive function, financial function, restriction diet and fluids, recreation, work, body image, symptoms, sex, sleep, access, and quality of life). The authors translated the CHEQ questionnaire into Thai and confirmed the accuracy by back translation. Pilot study sample was 10 Thai ESRD patients. Then the CHEQ (Thai) was applied to 110 Thai ESRD patients. Twenty-three patients had chronic peritoneal dialysis patients and 87 were chronic intermittent hemodialysis patients. Statistical analysis included descriptive statistics, Mann-Whitney U test, Student's t-test, and Cronbach's alpha. Construct validity was satisfactory with the significant difference less than 0.001 between the low and high group. The reliability coefficient for the Cronbach's alpha of the total scale of the CHEQ (Thai) was 0.98. The Cronbach 's alphas were greater than 0.7 for all domains, range from 0.58 to 0.92, except the social function and quality of life domain (alpha = 0.66 and 0.575). The CHEQ (Thai) is reliable and valid for assessment of Thai ESRD patients receiving chronic dialysis. Its properties are similar to those reported in the original version.

  1. Validating vignette and conjoint survey experiments against real-world behavior

    PubMed Central

    Hainmueller, Jens; Hangartner, Dominik; Yamamoto, Teppei

    2015-01-01

    Survey experiments, like vignette and conjoint analyses, are widely used in the social sciences to elicit stated preferences and study how humans make multidimensional choices. However, there is a paucity of research on the external validity of these methods that examines whether the determinants that explain hypothetical choices made by survey respondents match the determinants that explain what subjects actually do when making similar choices in real-world situations. This study compares results from conjoint and vignette analyses on which immigrant attributes generate support for naturalization with closely corresponding behavioral data from a natural experiment in Switzerland, where some municipalities used referendums to decide on the citizenship applications of foreign residents. Using a representative sample from the same population and the official descriptions of applicant characteristics that voters received before each referendum as a behavioral benchmark, we find that the effects of the applicant attributes estimated from the survey experiments perform remarkably well in recovering the effects of the same attributes in the behavioral benchmark. We also find important differences in the relative performances of the different designs. Overall, the paired conjoint design, where respondents evaluate two immigrants side by side, comes closest to the behavioral benchmark; on average, its estimates are within 2% percentage points of the effects in the behavioral benchmark. PMID:25646415

  2. Contactless experiments on individual DNA molecules show no evidence for molecular wire behavior.

    PubMed

    Gómez-Navarro, C; Moreno-Herrero, F; de Pablo, P J; Colchero, J; Gómez-Herrero, J; Baró, A M

    2002-06-25

    A fundamental requirement for a molecule to be considered a molecular wire (MW) is the ability to transport electrical charge with a reasonably low resistance. We have carried out two experiments that measure first, the charge transfer from an electrode to the molecule, and second, the dielectric response of the MW. The latter experiment requires no contacts to either end of the molecule. From our experiments we conclude that adsorbed individual DNA molecules have a resistivity similar to mica, glass, and silicon oxide substrates. Therefore adsorbed DNA is not a conductor, and it should not be considered as a viable candidate for MW applications. Parallel studies on other nanowires, including single-walled carbon nanotubes, showed conductivity as expected.

  3. Validation of spatial variability in downscaling results from the VALUE perfect predictor experiment

    NASA Astrophysics Data System (ADS)

    Widmann, Martin; Bedia, Joaquin; Gutiérrez, Jose Manuel; Maraun, Douglas; Huth, Radan; Fischer, Andreas; Keller, Denise; Hertig, Elke; Vrac, Mathieu; Wibig, Joanna; Pagé, Christian; Cardoso, Rita M.; Soares, Pedro MM; Bosshard, Thomas; Casado, Maria Jesus; Ramos, Petra

    2016-04-01

    VALUE is an open European network to validate and compare downscaling methods for climate change research. Within VALUE a systematic validation framework to enable the assessment and comparison of both dynamical and statistical downscaling methods has been developed. In the first validation experiment the downscaling methods are validated in a setup with perfect predictors taken from the ERA-interim reanalysis for the period 1997 - 2008. This allows to investigate the isolated skill of downscaling methods without further error contributions from the large-scale predictors. One aspect of the validation is the representation of spatial variability. As part of the VALUE validation we have compared various properties of the spatial variability of downscaled daily temperature and precipitation with the corresponding properties in observations. We have used two test validation datasets, one European-wide set of 86 stations, and one higher-density network of 50 stations in Germany. Here we present results based on three approaches, namely the analysis of i.) correlation matrices, ii.) pairwise joint threshold exceedances, and iii.) regions of similar variability. We summarise the information contained in correlation matrices by calculating the dependence of the correlations on distance and deriving decorrelation lengths, as well as by determining the independent degrees of freedom. Probabilities for joint threshold exceedances and (where appropriate) non-exceedances are calculated for various user-relevant thresholds related for instance to extreme precipitation or frost and heat days. The dependence of these probabilities on distance is again characterised by calculating typical length scales that separate dependent from independent exceedances. Regionalisation is based on rotated Principal Component Analysis. The results indicate which downscaling methods are preferable if the dependency of variability at different locations is relevant for the user.

  4. (In)validation in the Minority: The Experiences of Latino Students Enrolled in an HBCU

    ERIC Educational Resources Information Center

    Allen, Taryn Ozuna

    2016-01-01

    This qualitative, phenomenological study examined the academic and interpersonal validation experiences of four female and four male Latino students who were enrolled in their second- to fifth-year at an HBCU in Texas. Using interviews, campus observations, a questionnaire, and analytic memos, this study sought to understand the role of in- and…

  5. Assessing movement quality in persons with severe mental illness - Reliability and validity of the Body Awareness Scale Movement Quality and Experience.

    PubMed

    Hedlund, Lena; Gyllensten, Amanda Lundvik; Waldegren, Tomas; Hansson, Lars

    2016-05-01

    Motor disturbances and disturbed self-recognition are common features that affect mobility in persons with schizophrenia spectrum disorder and bipolar disorder. Physiotherapists in Scandinavia assess and treat movement difficulties in persons with severe mental illness. The Body Awareness Scale Movement Quality and Experience (BAS MQ-E) is a new and shortened version of the commonly used Body Awareness Scale-Health (BAS-H). The purpose of this study was to investigate the inter-rater reliability and the concurrent validity of BAS MQ-E in persons with severe mental illness. The concurrent validity was examined by investigating the relationships between neurological soft signs, alexithymia, fatigue, anxiety, and mastery. Sixty-two persons with severe mental illness participated in the study. The results showed a satisfactory inter-rater reliability (n = 53) and a concurrent validity (n = 62) with neurological soft signs, especially cognitive and perceptual based signs. There was also a concurrent validity linked to physical fatigue and aspects of alexithymia. The scores of BAS MQ-E were in general higher for persons with schizophrenia compared to persons with other diagnoses within the schizophrenia spectrum disorders and bipolar disorder. The clinical implications are presented in the discussion.

  6. The family experiences of in-hospital care questionnaire in severe traumatic brain injury (FECQ-TBI): a validation study.

    PubMed

    Anke, Audny; Manskow, Unn Sollid; Friborg, Oddgeir; Røe, Cecilie; Arntzen, Cathrine

    2016-11-28

    Family members are important for support and care of their close relative after severe traumas, and their experiences are vital health care quality indicators. The objective was to describe the development of the Family Experiences of in-hospital Care Questionnaire for family members of patients with severe Traumatic Brain Injury (FECQ-TBI), and to evaluate its psychometric properties and validity. The design of the study is a Norwegian multicentre study inviting 171 family members. The questionnaire developmental process included a literature review, use of an existing instrument (the parent experience of paediatric care questionnaire), focus group with close family members, as well as expert group judgments. Items asking for family care experiences related to acute wards and rehabilitation were included. Several items of the paediatric care questionnaire were removed or the wording of the items was changed to comply with the present purpose. Questions covering experiences with the inpatient rehabilitation period, the discharge phase, the family experiences with hospital facilities, the transfer between departments and the economic needs of the family were added. The developed questionnaire was mailed to the participants. Exploratory factor analyses were used to examine scale structure, in addition to screening for data quality, and analyses of internal consistency and validity. The questionnaire was returned by 122 (71%) of family members. Principal component analysis extracted six dimensions (eigenvalues > 1.0): acute organization and information (10 items), rehabilitation organization (13 items), rehabilitation information (6 items), discharge (4 items), hospital facilities-patients (4 items) and hospital facilities-family (2 items). Items related to the acute phase were comparable to items in the two dimensions of rehabilitation: organization and information. All six subscales had high Cronbach's alpha coefficients >0.80. The construct validity was

  7. Development and validation of the BRIGHTLIGHT Survey, a patient-reported experience measure for young people with cancer.

    PubMed

    Taylor, Rachel M; Fern, Lorna A; Solanki, Anita; Hooker, Louise; Carluccio, Anna; Pye, Julia; Jeans, David; Frere-Smith, Tom; Gibson, Faith; Barber, Julie; Raine, Rosalind; Stark, Dan; Feltbower, Richard; Pearce, Susie; Whelan, Jeremy S

    2015-07-28

    Patient experience is increasingly used as an indicator of high quality care in addition to more traditional clinical end-points. Surveys are generally accepted as appropriate methodology to capture patient experience. No validated patient experience surveys exist specifically for adolescents and young adults (AYA) aged 13-24 years at diagnosis with cancer. This paper describes early work undertaken to develop and validate a descriptive patient experience survey for AYA with cancer that encompasses both their cancer experience and age-related issues. We aimed to develop, with young people, an experience survey meaningful and relevant to AYA to be used in a longitudinal cohort study (BRIGHTLIGHT), ensuring high levels of acceptability to maximise study retention. A three-stage approach was employed: Stage 1 involved developing a conceptual framework, conducting literature/Internet searches and establishing content validity of the survey; Stage 2 confirmed the acceptability of methods of administration and consisted of four focus groups involving 11 young people (14-25 years), three parents and two siblings; and Stage 3 established survey comprehension through telephone-administered cognitive interviews with a convenience sample of 23 young people aged 14-24 years. Stage 1: Two-hundred and thirty eight questions were developed from qualitative reports of young people's cancer and treatment-related experience. Stage 2: The focus groups identified three core themes: (i) issues directly affecting young people, e.g. impact of treatment-related fatigue on ability to complete survey; (ii) issues relevant to the actual survey, e.g. ability to answer questions anonymously; (iii) administration issues, e.g. confusing format in some supporting documents. Stage 3: Cognitive interviews indicated high levels of comprehension requiring minor survey amendments. Collaborating with young people with cancer has enabled a survey of to be developed that is both meaningful to young

  8. EPIC Calibration/Validation Experiment Field Campaign Report

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Koch, Steven E; Chilson, Phillip; Argrow, Brian

    A field exercise involving several different kinds of Unmanned Aerial Systems (UAS) and supporting instrumentation systems provided by DOE/ARM and NOAA/NSSL was conducted at the ARM SGP site in Lamont, Oklahoma on 29-30 October 2016. This campaign was part of a larger National Oceanic and Atmospheric Administration (NOAA) UAS Program Office program awarded to the National Severe Storms Laboratory (NSSL). named Environmental Profiling and Initiation of Convection (EPIC). The EPIC Field Campaign (Test and Calibration/Validation) proposed to ARM was a test or “dry-run” for a follow-up campaign to be requested for spring/summer 2017. The EPIC project addresses NOAA’s objective tomore » “evaluate options for UAS profiling of the lower atmosphere with applications for severe weather.” The project goal is to demonstrate that fixed-wing and rotary-wing small UAS have the combined potential to provide a unique observing system capable of providing detailed profiles of temperature, moisture, and winds within the atmospheric boundary layer (ABL) to help determine the potential for severe weather development. Specific project objectives are: 1) to develop small UAS capable of acquiring needed wind and thermodynamic profiles and transects of the ABL using one fixed-wing UAS operating in tandem with two different fixed rotary-wing UAS pairs; 2) adapt and test miniaturized, high-precision, and fast-response atmospheric sensors with high accuracy in strong winds characteristic of the pre-convective ABL in Oklahoma; 3) conduct targeted short-duration experiments at the ARM Southern Great Plains site in northern Oklahoma concurrently with a second site to be chosen in “real-time” from the Oklahoma Mesonet in coordination with the (National Weather Service (NWS)-Norman Forecast Office; and 4) gain valuable experience in pursuit of NOAA’s goals for determining the value of airborne, mobile observing systems for monitoring rapidly evolving high-impact severe weather

  9. Father for the first time - development and validation of a questionnaire to assess fathers’ experiences of first childbirth (FTFQ)

    PubMed Central

    2012-01-01

    Background A father’s experience of the birth of his first child is important not only for his birth-giving partner but also for the father himself, his relationship with the mother and the newborn. No validated questionnaire assessing first-time fathers' experiences during childbirth is currently available. Hence, the aim of this study was to develop and validate an instrument to assess first-time fathers’ experiences of childbirth. Method Domains and items were initially derived from interviews with first-time fathers, and supplemented by a literature search and a focus group interview with midwives. The comprehensibility, comprehension and relevance of the items were evaluated by four paternity research experts and a preliminary questionnaire was pilot tested in eight first-time fathers. A revised questionnaire was completed by 200 first-time fathers (response rate = 81%) Exploratory factor analysis using principal component analysis with varimax rotation was performed and multitrait scaling analysis was used to test scaling assumptions. External validity was assessed by means of known-groups analysis. Results Factor analysis yielded four factors comprising 22 items and accounting 48% of the variance. The domains found were Worry, Information, Emotional support and Acceptance. Multitrait analysis confirmed the convergent and discriminant validity of the domains; however, Cronbach’s alpha did not meet conventional reliability standards in two domains. The questionnaire was sensitive to differences between groups of fathers hypothesized to differ on important socio demographic or clinical variables. Conclusions The questionnaire adequately measures important dimensions of first-time fathers’ childbirth experience and may be used to assess aspects of fathers’ experiences during childbirth. To obtain the FTFQ and permission for its use, please contact the corresponding author. PMID:22594834

  10. Father for the first time--development and validation of a questionnaire to assess fathers' experiences of first childbirth (FTFQ).

    PubMed

    Premberg, Åsa; Taft, Charles; Hellström, Anna-Lena; Berg, Marie

    2012-05-17

    A father's experience of the birth of his first child is important not only for his birth-giving partner but also for the father himself, his relationship with the mother and the newborn. No validated questionnaire assessing first-time fathers' experiences during childbirth is currently available. Hence, the aim of this study was to develop and validate an instrument to assess first-time fathers' experiences of childbirth. Domains and items were initially derived from interviews with first-time fathers, and supplemented by a literature search and a focus group interview with midwives. The comprehensibility, comprehension and relevance of the items were evaluated by four paternity research experts and a preliminary questionnaire was pilot tested in eight first-time fathers. A revised questionnaire was completed by 200 first-time fathers (response rate = 81%) Exploratory factor analysis using principal component analysis with varimax rotation was performed and multitrait scaling analysis was used to test scaling assumptions. External validity was assessed by means of known-groups analysis. Factor analysis yielded four factors comprising 22 items and accounting 48% of the variance. The domains found were Worry, Information, Emotional support and Acceptance. Multitrait analysis confirmed the convergent and discriminant validity of the domains; however, Cronbach's alpha did not meet conventional reliability standards in two domains. The questionnaire was sensitive to differences between groups of fathers hypothesized to differ on important socio demographic or clinical variables. The questionnaire adequately measures important dimensions of first-time fathers' childbirth experience and may be used to assess aspects of fathers' experiences during childbirth. To obtain the FTFQ and permission for its use, please contact the corresponding author.

  11. 2-D Circulation Control Airfoil Benchmark Experiments Intended for CFD Code Validation

    NASA Technical Reports Server (NTRS)

    Englar, Robert J.; Jones, Gregory S.; Allan, Brian G.; Lin, Johb C.

    2009-01-01

    A current NASA Research Announcement (NRA) project being conducted by Georgia Tech Research Institute (GTRI) personnel and NASA collaborators includes the development of Circulation Control (CC) blown airfoils to improve subsonic aircraft high-lift and cruise performance. The emphasis of this program is the development of CC active flow control concepts for both high-lift augmentation, drag control, and cruise efficiency. A collaboration in this project includes work by NASA research engineers, whereas CFD validation and flow physics experimental research are part of NASA s systematic approach to developing design and optimization tools for CC applications to fixed-wing aircraft. The design space for CESTOL type aircraft is focusing on geometries that depend on advanced flow control technologies that include Circulation Control aerodynamics. The ability to consistently predict advanced aircraft performance requires improvements in design tools to include these advanced concepts. Validation of these tools will be based on experimental methods applied to complex flows that go beyond conventional aircraft modeling techniques. This paper focuses on recent/ongoing benchmark high-lift experiments and CFD efforts intended to provide 2-D CFD validation data sets related to NASA s Cruise Efficient Short Take Off and Landing (CESTOL) study. Both the experimental data and related CFD predictions are discussed.

  12. The Development and Validation of the Social Networking Experiences Questionnaire: A Measure of Adolescent Cyberbullying and Its Impact.

    PubMed

    Dredge, Rebecca; Gleeson, John; Garcia, Xochitl de la Piedad

    2015-01-01

    The measurement of cyberbullying has been marked by several inconsistencies that lead to difficulties in cross-study comparisons of the frequency of occurrence and the impact of cyberbullying. Consequently, the first aim of this study was to develop a measure of experience with and impact of cyberbullying victimization in social networking sites in adolescents. The second aim was to investigate the psychometric properties of a purpose-built measure (Social Networking Experiences Questionnaire [SNEQ]). Exploratory factor analysis on 253 adolescent social networking sites users produced a six-factor model of impact. However, one factor was removed because of low internal consistency. Cronbach's alpha was higher than .76 for the victimization and remaining five impact subscales. Furthermore, correlation coefficients for the Victimization scale and related dimensions showed good construct validity. The utility of the SNEQ for victim support personnel, research, and cyberbullying education/prevention programs is discussed.

  13. Quality Control and Analysis of Microphysical Data Collected in TRMM Aircraft Validation Experiments

    NASA Technical Reports Server (NTRS)

    Heymsfield, Andrew J.

    2004-01-01

    This report summarizes our efforts on the funded project 'Quality Control and Analysis of Microphysical Data Collected in TRMM Airborne Validation Experiments', NASA NAG5-9663, Andrew Heymsfield, P. I. We begin this report by summarizing our activities in FY2000-FY2004. We then present some highlights of our work. The last part of the report lists the publications that have resulted from our funding through this grant.

  14. Dog owners show experience-based viewing behaviour in judging dog face approachability.

    PubMed

    Gavin, Carla Jade; Houghton, Sarah; Guo, Kun

    2017-01-01

    Our prior visual experience plays a critical role in face perception. We show superior perceptual performance for differentiating conspecific (vs non-conspecific), own-race (vs other-race) and familiar (vs unfamiliar) faces. However, it remains unclear whether our experience with faces of other species would influence our gaze allocation for extracting salient facial information. In this eye-tracking study, we asked both dog owners and non-owners to judge the approachability of human, monkey and dog faces, and systematically compared their behavioural performance and gaze pattern associated with the task. Compared to non-owners, dog owners assessed dog faces with shorter time and fewer fixations, but gave higher approachability ratings. The gaze allocation within local facial features was also modulated by the ownership. The averaged proportion of the fixations and viewing time directed at the dog mouth region were significantly less for the dog owners, and more experienced dog owners tended to look more at the dog eyes, suggesting the adoption of a prior experience-based viewing behaviour for assessing dog approachability. No differences in behavioural performance and gaze pattern were observed between dog owners and non-owners when judging human and monkey faces, implying that the dog owner's experience-based gaze strategy for viewing dog faces was not transferable across faces of other species.

  15. Improving the quality of discrete-choice experiments in health: how can we assess validity and reliability?

    PubMed

    Janssen, Ellen M; Marshall, Deborah A; Hauber, A Brett; Bridges, John F P

    2017-12-01

    The recent endorsement of discrete-choice experiments (DCEs) and other stated-preference methods by regulatory and health technology assessment (HTA) agencies has placed a greater focus on demonstrating the validity and reliability of preference results. Areas covered: We present a practical overview of tests of validity and reliability that have been applied in the health DCE literature and explore other study qualities of DCEs. From the published literature, we identify a variety of methods to assess the validity and reliability of DCEs. We conceptualize these methods to create a conceptual model with four domains: measurement validity, measurement reliability, choice validity, and choice reliability. Each domain consists of three categories that can be assessed using one to four procedures (for a total of 24 tests). We present how these tests have been applied in the literature and direct readers to applications of these tests in the health DCE literature. Based on a stakeholder engagement exercise, we consider the importance of study characteristics beyond traditional concepts of validity and reliability. Expert commentary: We discuss study design considerations to assess the validity and reliability of a DCE, consider limitations to the current application of tests, and discuss future work to consider the quality of DCEs in healthcare.

  16. Validation of Cross Sections with Criticality Experiment and Reaction Rates: the Neptunium Case

    NASA Astrophysics Data System (ADS)

    Leong, L. S.; Tassan-Got, L.; Audouin, L.; Berthier, B.; Le Naour, C.; Stéphan, C.; Paradela, C.; Tarrío, D.; Duran, I.

    2014-04-01

    The 237Np neutron-induced fission cross section has been recently measured in a large energy range (from eV to GeV) at the n_TOF facility at CERN. When compared to previous measurements the n_TOF fission cross section appears to be higher by 5-7% beyond the fission threshold. To check the relevance of the n_TOF data, we considered a criticality experiment performed at Los Alamos with a 6 kg sphere of 237Np, surrounded by uranium highly enriched in 235U so as to approach criticality with fast neutrons. The multiplication factor keff of the calculation is in better agreement with the experiment when we replace the ENDF/B-VII.0 evaluation of the 237Np fission cross section by the n_TOF data. We also explored the hypothesis of deficiencies of the inelastic cross section in 235U which has been invoked by some authors to explain the deviation of 750 pcm. The large modification needed to reduce the deviation seems to be incompatible with existing inelastic cross section measurements. Also we show that the νbar of 237Np can hardly be incriminated because of the high accuracy of the existing data. Fission rate ratios or averaged fission cross sections measured in several fast neutron fields seem to give contradictory results on the validation of the 237Np cross section but at least one of the benchmark experiments, where the active deposits have been well calibrated for the number of atoms, favors the n_TOF data set. These outcomes support the hypothesis of a higher fission cross section of 237Np.

  17. Psychological and interactional characteristics of patients with somatoform disorders: Validation of the Somatic Symptoms Experiences Questionnaire (SSEQ) in a clinical psychosomatic population.

    PubMed

    Herzog, Annabel; Voigt, Katharina; Meyer, Björn; Wollburg, Eileen; Weinmann, Nina; Langs, Gernot; Löwe, Bernd

    2015-06-01

    The new DSM-5 Somatic Symptom Disorder (SSD) emphasizes the importance of psychological processes related to somatic symptoms in patients with somatoform disorders. To address this, the Somatic Symptoms Experiences Questionnaire (SSEQ), the first self-report scale that assesses a broad range of psychological and interactional characteristics relevant to patients with a somatoform disorder or SSD, was developed. This prospective study was conducted to validate the SSEQ. The 15-item SSEQ was administered along with a battery of self-report questionnaires to psychosomatic inpatients. Patients were assessed with the Structured Clinical Interview for DSM-IV to confirm a somatoform, depressive, or anxiety disorder. Confirmatory factor analyses, tests of internal consistency and tests of validity were performed. Patients (n=262) with a mean age of 43.4 years, 60.3% women, were included in the analyses. The previously observed four-factor model was replicated and internal consistency was good (Cronbach's α=.90). Patients with a somatoform disorder had significantly higher scores on the SSEQ (t=4.24, p<.001) than patients with a depressive/anxiety disorder. Construct validity was shown by high correlations with other instruments measuring related constructs. Hierarchical multiple regression analyses showed that the questionnaire predicted health-related quality of life. Sensitivity to change was shown by significantly higher effect sizes of the SSEQ change scores for improved patients than for patients without improvement. The SSEQ appears to be a reliable, valid, and efficient instrument to assess a broad range of psychological and interactional features related to the experience of somatic symptoms. Copyright © 2015 Elsevier Inc. All rights reserved.

  18. A design of experiments approach to validation sampling for logistic regression modeling with error-prone medical records.

    PubMed

    Ouyang, Liwen; Apley, Daniel W; Mehrotra, Sanjay

    2016-04-01

    Electronic medical record (EMR) databases offer significant potential for developing clinical hypotheses and identifying disease risk associations by fitting statistical models that capture the relationship between a binary response variable and a set of predictor variables that represent clinical, phenotypical, and demographic data for the patient. However, EMR response data may be error prone for a variety of reasons. Performing a manual chart review to validate data accuracy is time consuming, which limits the number of chart reviews in a large database. The authors' objective is to develop a new design-of-experiments-based systematic chart validation and review (DSCVR) approach that is more powerful than the random validation sampling used in existing approaches. The DSCVR approach judiciously and efficiently selects the cases to validate (i.e., validate whether the response values are correct for those cases) for maximum information content, based only on their predictor variable values. The final predictive model will be fit using only the validation sample, ignoring the remainder of the unvalidated and unreliable error-prone data. A Fisher information based D-optimality criterion is used, and an algorithm for optimizing it is developed. The authors' method is tested in a simulation comparison that is based on a sudden cardiac arrest case study with 23 041 patients' records. This DSCVR approach, using the Fisher information based D-optimality criterion, results in a fitted model with much better predictive performance, as measured by the receiver operating characteristic curve and the accuracy in predicting whether a patient will experience the event, than a model fitted using a random validation sample. The simulation comparisons demonstrate that this DSCVR approach can produce predictive models that are significantly better than those produced from random validation sampling, especially when the event rate is low. © The Author 2015. Published by Oxford

  19. Validation of the Child HCAHPS survey to measure pediatric inpatient experience of care in Flanders.

    PubMed

    Bruyneel, Luk; Coeckelberghs, Ellen; Buyse, Gunnar; Casteels, Kristina; Lommers, Barbara; Vandersmissen, Jo; Van Eldere, Johan; Van Geet, Chris; Vanhaecht, Kris

    2017-07-01

    The recently developed Child HCAHPS provides a standard to measure US hospitals' performance on pediatric inpatient experiences of care. We field-tested Child HCAHPS in Belgium to instigate international comparison. In the development stage, forward/backward translation was conducted and patients assessed content validity index as excellent. The draft Flemish Child HCAHPS included 63 items: 38 items for five topics hypothesized to be similar to those proposed in the US (communication with parent, communication with child, attention to safety and comfort, hospital environment, and global rating), 10 screeners, a 14-item demographic and descriptive section, and one open-ended item. A 6-week pilot test was subsequently performed in three pediatric wards (general ward, hematology and oncology ward, infant and toddler ward) at a JCI-accredited university hospital. An overall response rate of 90.99% (303/333) was achieved and was consistent across wards. Confirmatory factor analysis largely confirmed the configuration of the proposed composites. Composite and single-item measures related well to patients' global rating of the hospital. Interpretation of different patient experiences across types of wards merits further investigation. Child HCAHPS provides an opportunity for systematic and cross-national assessment of pediatric inpatient experiences. Sharing and implementing international best practices are the next logical step. What is Known: • Patient experience surveys are increasingly used to reflect on the quality, safety, and centeredness of patient care. • While adult inpatient experience surveys are routinely used across countries around the world, the measurement of pediatric inpatient experiences is a young field of research that is essential to reflect on family-centered care. What is New: • We demonstrate that the US-developed Child HCAHPS provides an opportunity for international benchmarking of pediatric inpatient experiences with care through parents

  20. Comparing Derived and Actual Upwelling Longwave Measurements at the CERES Ocean Validation Experiment (COVE)

    NASA Astrophysics Data System (ADS)

    Fabbri, B. E.; Schuster, G. L.; Denn, F. M.; Arduini, R. F.; Madigan, J. J.

    2017-12-01

    One of the parameters measured from the Clouds and the Earth's Radiant Energy System (CERES) satellite is Earth emitted or longwave (LW) radiation. One validation site to compare this quantity is the CERES Ocean Validation Experiment (COVE), located at Chesapeake Light Station, approximately 25 kilometers east of Virginia Beach, Virginia (coordinates: 36.90N, 75.71W). However, the upwelling measurement is complicated due to the Light Station tower being in the LW instruments field of view. A negative outcome of the tower being in the field of view is a tower radiating effect, especially noticeable on clear, sunny days. During these days, the tower tends to heat up and radiate extra heat energy that is measured by the LW instrument. To understand the extent of the problem, we derive upwelling longwave measurements at the surface using sea surface temperature, air temperature, and dewpoint to compare with the actual longwave measurement made with an Eppley Laboratory pyrgeometer. The data used in this study is over a four-year period (2009-2012). One result using only nighttime data (range: 15.0 =< sa <= 55.0) shows the relative error between actual versus derived being low. The resultant statistics produced a mean, median, standard deviation and standard error to be -0.378, -0.14, 1.906 and 0.005 respectively. This low error is not too surprising since there is no solar insolation creating the tower radiating effect. Other results comparing the diurnal scope are analyzed and presented.

  1. Unsteady Aerodynamic Validation Experiences From the Aeroelastic Prediction Workshop

    NASA Technical Reports Server (NTRS)

    Heeg, Jennifer; Chawlowski, Pawel

    2014-01-01

    The AIAA Aeroelastic Prediction Workshop (AePW) was held in April 2012, bringing together communities of aeroelasticians, computational fluid dynamicists and experimentalists. The extended objective was to assess the state of the art in computational aeroelastic methods as practical tools for the prediction of static and dynamic aeroelastic phenomena. As a step in this process, workshop participants analyzed unsteady aerodynamic and weakly-coupled aeroelastic cases. Forced oscillation and unforced system experiments and computations have been compared for three configurations. This paper emphasizes interpretation of the experimental data, computational results and their comparisons from the perspective of validation of unsteady system predictions. The issues examined in detail are variability introduced by input choices for the computations, post-processing, and static aeroelastic modeling. The final issue addressed is interpreting unsteady information that is present in experimental data that is assumed to be steady, and the resulting consequences on the comparison data sets.

  2. A newly developed tool for classifying study designs in systematic reviews of interventions and exposures showed substantial reliability and validity.

    PubMed

    Seo, Hyun-Ju; Kim, Soo Young; Lee, Yoon Jae; Jang, Bo-Hyoung; Park, Ji-Eun; Sheen, Seung-Soo; Hahn, Seo Kyung

    2016-02-01

    To develop a study Design Algorithm for Medical Literature on Intervention (DAMI) and test its interrater reliability, construct validity, and ease of use. We developed and then revised the DAMI to include detailed instructions. To test the DAMI's reliability, we used a purposive sample of 134 primary, mainly nonrandomized studies. We then compared the study designs as classified by the original authors and through the DAMI. Unweighted kappa statistics were computed to test interrater reliability and construct validity based on the level of agreement between the original and DAMI classifications. Assessment time was also recorded to evaluate ease of use. The DAMI includes 13 study designs, including experimental and observational studies of interventions and exposure. Both the interrater reliability (unweighted kappa = 0.67; 95% CI [0.64-0.75]) and construct validity (unweighted kappa = 0.63, 95% CI [0.52-0.67]) were substantial. Mean classification time using the DAMI was 4.08 ± 2.44 minutes (range, 0.51-10.92). The DAMI showed substantial interrater reliability and construct validity. Furthermore, given its ease of use, it could be used to accurately classify medical literature for systematic reviews of interventions although minimizing disagreement between authors of such reviews. Copyright © 2016 Elsevier Inc. All rights reserved.

  3. The NASA CloudSat/GPM Light Precipitation Validation Experiment (LPVEx)

    NASA Technical Reports Server (NTRS)

    Petersen, Walter A.; L'Ecuyer, Tristan; Moisseev, Dmitri

    2011-01-01

    Ground-based measurements of cool-season precipitation at mid and high latitudes (e.g., above 45 deg N/S) suggest that a significant fraction of the total precipitation volume falls in the form of light rain, i.e., at rates less than or equal to a few mm/h. These cool-season light rainfall events often originate in situations of a low-altitude (e.g., lower than 2 km) melting level and pose a significant challenge to the fidelity of all satellite-based precipitation measurements, especially those relying on the use of multifrequency passive microwave (PMW) radiometers. As a result, significant disagreements exist between satellite estimates of rainfall accumulation poleward of 45 deg. Ongoing efforts to develop, improve, and ultimately evaluate physically-based algorithms designed to detect and accurately quantify high latitude rainfall, however, suffer from a general lack of detailed, observationally-based ground validation datasets. These datasets serve as a physically consistent framework from which to test and refine algorithm assumptions, and as a means to build the library of algorithm retrieval databases in higher latitude cold-season light precipitation regimes. These databases are especially relevant to NASA's CloudSat and Global Precipitation Measurement (GPM) ground validation programs that are collecting high-latitude precipitation measurements in meteorological systems associated with frequent coolseason light precipitation events. In an effort to improve the inventory of cool-season high-latitude light precipitation databases and advance the physical process assumptions made in satellite-based precipitation retrieval algorithm development, the CloudSat and GPM mission ground validation programs collaborated with the Finnish Meteorological Institute (FMI), the University of Helsinki (UH), and Environment Canada (EC) to conduct the Light Precipitation Validation Experiment (LPVEx). The LPVEx field campaign was designed to make detailed measurements of

  4. Directed Design of Experiments for Validating Probability of Detection Capability of NDE Systems (DOEPOD)

    NASA Technical Reports Server (NTRS)

    Generazio, Edward R.

    2015-01-01

    Directed Design of Experiments for Validating Probability of Detection Capability of NDE Systems (DOEPOD) Manual v.1.2 The capability of an inspection system is established by applications of various methodologies to determine the probability of detection (POD). One accepted metric of an adequate inspection system is that there is 95% confidence that the POD is greater than 90% (90/95 POD). Design of experiments for validating probability of detection capability of nondestructive evaluation (NDE) systems (DOEPOD) is a methodology that is implemented via software to serve as a diagnostic tool providing detailed analysis of POD test data, guidance on establishing data distribution requirements, and resolving test issues. DOEPOD demands utilization of observance of occurrences. The DOEPOD capability has been developed to provide an efficient and accurate methodology that yields observed POD and confidence bounds for both Hit-Miss or signal amplitude testing. DOEPOD does not assume prescribed POD logarithmic or similar functions with assumed adequacy over a wide range of flaw sizes and inspection system technologies, so that multi-parameter curve fitting or model optimization approaches to generate a POD curve are not required. DOEPOD applications for supporting inspector qualifications is included.

  5. Students' and Teacher's Experiences of the Validity and Reliability of Assessment in a Bioscience Course

    ERIC Educational Resources Information Center

    Räisänen, Milla; Tuononen, Tarja; Postareff, Liisa; Hailikari, Telle; Virtanen, Viivi

    2016-01-01

    This case study explores the assessment of students' learning outcomes in a second-year lecture course in biosciences. The aim is to deeply explore the teacher's and the students' experiences of the validity and reliability of assessment and to compare those perspectives. The data were collected through stimulated recall interviews. The results…

  6. Validating An Analytic Completeness Model for Kepler Target Stars Based on Flux-level Transit Injection Experiments

    NASA Astrophysics Data System (ADS)

    Catanzarite, Joseph; Burke, Christopher J.; Li, Jie; Seader, Shawn; Haas, Michael R.; Batalha, Natalie; Henze, Christopher; Christiansen, Jessie; Kepler Project, NASA Advanced Supercomputing Division

    2016-06-01

    The Kepler Mission is developing an Analytic Completeness Model (ACM) to estimate detection completeness contours as a function of exoplanet radius and period for each target star. Accurate completeness contours are necessary for robust estimation of exoplanet occurrence rates.The main components of the ACM for a target star are: detection efficiency as a function of SNR, the window function (WF) and the one-sigma depth function (OSDF). (Ref. Burke et al. 2015). The WF captures the falloff in transit detection probability at long periods that is determined by the observation window (the duration over which the target star has been observed). The OSDF is the transit depth (in parts per million) that yields SNR of unity for the full transit train. It is a function of period, and accounts for the time-varying properties of the noise and for missing or deweighted data.We are performing flux-level transit injection (FLTI) experiments on selected Kepler target stars with the goal of refining and validating the ACM. “Flux-level” injection machinery inserts exoplanet transit signatures directly into the flux time series, as opposed to “pixel-level” injection, which inserts transit signatures into the individual pixels using the pixel response function. See Jie Li's poster: ID #2493668, "Flux-level transit injection experiments with the NASA Pleiades Supercomputer" for details, including performance statistics.Since FLTI is affordable for only a small subset of the Kepler targets, the ACM is designed to apply to most Kepler target stars. We validate this model using “deep” FLTI experiments, with ~500,000 injection realizations on each of a small number of targets and “shallow” FLTI experiments with ~2000 injection realizations on each of many targets. From the results of these experiments, we identify anomalous targets, model their behavior and refine the ACM accordingly.In this presentation, we discuss progress in validating and refining the ACM, and we

  7. STORMVEX: The Storm Peak Lab Cloud Property Validation Experiment Science and Operations Plan

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Mace, J; Matrosov, S; Shupe, M

    2010-09-29

    During the Storm Peak Lab Cloud Property Validation Experiment (STORMVEX), a substantial correlative data set of remote sensing observations and direct in situ measurements from fixed and airborne platforms will be created in a winter season, mountainous environment. This will be accomplished by combining mountaintop observations at Storm Peak Laboratory and the airborne National Science Foundation-supported Colorado Airborne Multi-Phase Cloud Study campaign with collocated measurements from the second ARM Mobile Facility (AMF2). We describe in this document the operational plans and motivating science for this experiment, which includes deployment of AMF2 to Steamboat Springs, Colorado. The intensive STORMVEX field phasemore » will begin nominally on 1 November 2010 and extend to approximately early April 2011.« less

  8. NASA 9-Point LDI Code Validation Experiment

    NASA Technical Reports Server (NTRS)

    Hicks, Yolanda R.; Anderson, Robert C.; Locke, Randy J.

    2007-01-01

    This presentation highlights the experimental work to date to obtain validation data using a 9-point lean direct injector (LDI) in support of the National Combustion Code. The LDI is designed to supply fuel lean, Jet-A and air directly into the combustor such that the liquid fuel atomizes and mixes rapidly to produce short flame zones and produce low levels of oxides of nitrogen and CO. We present NOx and CO emission results from gas sample data that support that aspect of the design concept. We describe this injector and show high speed movies of selected operating points. We present image-based species maps of OH, fuel, CH and NO obtained using planar laser induced fluorescence and chemiluminescence. We also present preliminary 2-component, axial and vertical, velocity vectors of the air flow obtained using particle image velocimetry and of the fuel drops in a combusting case. For the same combusting case, we show preliminary 3-component velocity vectors obtained using a phase Doppler anemometer. For the fueled, combusting cases especially, we found optical density is a technical concern that must be addressed, but that in general, these preliminary results are promising. All optical-based results confirm that this injector produces short flames, typically on the order of 5- to-7-mm long at typical cruise and high power engine cycle conditions.

  9. Assessing positive and negative experiences: validation of a new measure of well-being in an Italian population.

    PubMed

    Corno, Giulia; Molinari, Guadalupe; Baños, Rosa Maria

    2016-01-01

    The aim of this study is to explore the psychometric properties of an affect scale, the Scale of Positive and Negative Experience (SPANE), in an Italian-speaking population. The results of this study demonstrate that the Italian version of the SPANE has psychometric properties similar to those shown by the original and previous versions, and it presents satisfactory reliability and factorial validity. The results of the Confirmatory Factor Analysis support the expected two-factor structure, positive and negative feeling, which characterized the previous versions. As expected, measures of negative affect, anxiety, negative future expectances, and depression correlated positively with the negative experiences SPANE subscale, and negatively with the positive experiences SPANE subscale. Results of this study demonstrate that the Italian version of the SPANE has psychometric properties similar to those shown by the original and previous versions, and it presents satisfactory reliability and factorial validity. The use of this instrument provides clinically useful information about a person’s overall emotional experience and it is an indicator of well-being. Although further studies are required to confirm the psychometric characteristics of the scale, the SPANE Italian version is expected to improve theoretical and empirical research on the well-being of the Italian population.

  10. System Validation Experiments for Obtaining Tracer Laser-Induced Fluorescence Data at Elevated Pressure and Temperature.

    PubMed

    Hartwig, Jason; Mittal, Gaurav; Kumar, Kamal; Sung, Chih-Jen

    2018-04-01

    This paper presents a set of system validation experiments that can be used to qualify either static or flow experimental systems for gathering tracer photophysical data or conducting laser diagnostics at high pressure and temperature in order to establish design and operation limits and reduce uncertainty in data interpretation. Tests demonstrated here quantify the effect of tracer absorption at the test cell walls, stratification, photolysis, pyrolysis, adequacy of mixing and seeding, and reabsorption of laser light using acetone as the tracer and 282 nm excitation. Results show that acetone exhibits a 10% decrease in fluorescence signal over 36 000 shots at 127.4 mJ/cm 2 , and photolysis is negligible below 1000 shots collected. Meanwhile, appropriately chosen gas residence times can mitigate risks due to pyrolysis and inadequate mixing and seeding; for the current work 100 ms residence time ensured <0.5% alteration of tracer number density due to thermal destruction. Experimental results here are compared to theoretical values from the literature.

  11. The List of Threatening Experiences: the reliability and validity of a brief life events questionnaire.

    PubMed

    Brugha, T S; Cragg, D

    1990-07-01

    During the 23 years since the original work of Holmes & Rahe, research into stressful life events on human subjects has tended towards the development of longer and more complex inventories. The List of Threatening Experiences (LTE) of Brugha et al., by virtue of its brevity, overcomes difficulties of clinical application. In a study of 50 psychiatric patients and informants, the questionnaire version of the list (LTE-Q) was shown to have high test-retest reliability, and good agreement with informant information. Concurrent validity, based on the criterion of independently rated adversity derived from a semistructured life events interview, making use of the Life Events and Difficulties Scales (LEDS) method developed by Brown & Harris, showed both high specificity and sensitivity. The LTE-Q is particularly recommended for use in psychiatric, psychological and social studies in which other intervening variables such as social support, coping, and cognitive variables are of interest, and resources do not allow for the use of extensive interview measures of stress.

  12. The brief negative symptom scale: validation of the German translation and convergent validity with self-rated anhedonia and observer-rated apathy.

    PubMed

    Bischof, Martin; Obermann, Caitriona; Hartmann, Matthias N; Hager, Oliver M; Kirschner, Matthias; Kluge, Agne; Strauss, Gregory P; Kaiser, Stefan

    2016-11-22

    Negative symptoms are considered core symptoms of schizophrenia. The Brief Negative Symptom Scale (BNSS) was developed to measure this symptomatic dimension according to a current consensus definition. The present study examined the psychometric properties of the German version of the BNSS. To expand former findings on convergent validity, we employed the Temporal Experience Pleasure Scale (TEPS), a hedonic self-report that distinguishes between consummatory and anticipatory pleasure. Additionally, we addressed convergent validity with observer-rated assessment of apathy with the Apathy Evaluation Scale (AES), which was completed by the patient's primary nurse. Data were collected from 75 in- and outpatients from the Psychiatric Hospital, University Zurich diagnosed with either schizophrenia or schizoaffective disorder. We assessed convergent and discriminant validity, internal consistency and inter-rater reliability. We largely replicated the findings of the original version showing good psychometric properties of the BNSS. In addition, the primary nurses evaluation correlated moderately with interview-based clinician rating. BNSS anhedonia items showed good convergent validity with the TEPS. Overall, the German BNSS shows good psychometric properties comparable to the original English version. Convergent validity extends beyond interview-based assessments of negative symptoms to self-rated anhedonia and observer-rated apathy.

  13. Use of integral experiments in support to the validation of JEFF-3.2 nuclear data evaluation

    NASA Astrophysics Data System (ADS)

    Leclaire, Nicolas; Cochet, Bertrand; Jinaphanh, Alexis; Haeck, Wim

    2017-09-01

    For many years now, IRSN has developed its own Monte Carlo continuous energy capability, which allows testing various nuclear data libraries. In that prospect, a validation database of 1136 experiments was built from cases used for the validation of the APOLLO2-MORET 5 multigroup route of the CRISTAL V2.0 package. In this paper, the keff obtained for more than 200 benchmarks using the JEFF-3.1.1 and JEFF-3.2 libraries are compared to benchmark keff values and main discrepancies are analyzed regarding the neutron spectrum. Special attention is paid on benchmarks for which the results have been highly modified between both JEFF-3 versions.

  14. Validation of scaffold design optimization in bone tissue engineering: finite element modeling versus designed experiments.

    PubMed

    Uth, Nicholas; Mueller, Jens; Smucker, Byran; Yousefi, Azizeh-Mitra

    2017-02-21

    This study reports the development of biological/synthetic scaffolds for bone tissue engineering (TE) via 3D bioplotting. These scaffolds were composed of poly(L-lactic-co-glycolic acid) (PLGA), type I collagen, and nano-hydroxyapatite (nHA) in an attempt to mimic the extracellular matrix of bone. The solvent used for processing the scaffolds was 1,1,1,3,3,3-hexafluoro-2-propanol. The produced scaffolds were characterized by scanning electron microscopy, microcomputed tomography, thermogravimetric analysis, and unconfined compression test. This study also sought to validate the use of finite-element optimization in COMSOL Multiphysics for scaffold design. Scaffold topology was simplified to three factors: nHA content, strand diameter, and strand spacing. These factors affect the ability of the scaffold to bear mechanical loads and how porous the structure can be. Twenty four scaffolds were constructed according to an I-optimal, split-plot designed experiment (DE) in order to generate experimental models of the factor-response relationships. Within the design region, the DE and COMSOL models agreed in their recommended optimal nHA (30%) and strand diameter (460 μm). However, the two methods disagreed by more than 30% in strand spacing (908 μm for DE; 601 μm for COMSOL). Seven scaffolds were 3D-bioplotted to validate the predictions of DE and COMSOL models (4.5-9.9 MPa measured moduli). The predictions for these scaffolds showed relative agreement for scaffold porosity (mean absolute percentage error of 4% for DE and 13% for COMSOL), but were substantially poorer for scaffold modulus (51% for DE; 21% for COMSOL), partly due to some simplifying assumptions made by the models. Expanding the design region in future experiments (e.g., higher nHA content and strand diameter), developing an efficient solvent evaporation method, and exerting a greater control over layer overlap could allow developing PLGA-nHA-collagen scaffolds to meet the mechanical requirements for

  15. In-Trail Procedure Air Traffic Control Procedures Validation Simulation Study

    NASA Technical Reports Server (NTRS)

    Chartrand, Ryan C.; Hewitt, Katrin P.; Sweeney, Peter B.; Graff, Thomas J.; Jones, Kenneth M.

    2012-01-01

    In August 2007, Airservices Australia (Airservices) and the United States National Aeronautics and Space Administration (NASA) conducted a validation experiment of the air traffic control (ATC) procedures associated with the Automatic Dependant Surveillance-Broadcast (ADS-B) In-Trail Procedure (ITP). ITP is an Airborne Traffic Situation Awareness (ATSA) application designed for near-term use in procedural airspace in which ADS-B data are used to facilitate climb and descent maneuvers. NASA and Airservices conducted the experiment in Airservices simulator in Melbourne, Australia. Twelve current operational air traffic controllers participated in the experiment, which identified aspects of the ITP that could be improved (mainly in the communication and controller approval process). Results showed that controllers viewed the ITP as valid and acceptable. This paper describes the experiment design and results.

  16. [Perception scales of validated food insecurity: the experience of the countries in Latin America and the Caribbean].

    PubMed

    Sperandio, Naiara; Morais, Dayane de Castro; Priore, Silvia Eloiza

    2018-02-01

    The scope of this systematic review was to compare the food insecurity scales validated and used in the countries in Latin America and the Caribbean, and analyze the methods used in validation studies. A search was conducted in the Lilacs, SciELO and Medline electronic databases. The publications were pre-selected by titles and abstracts, and subsequently by a full reading. Of the 16,325 studies reviewed, 14 were selected. Twelve validated scales were identified for the following countries: Venezuela, Brazil, Colombia, Bolivia, Ecuador, Costa Rica, Mexico, Haiti, the Dominican Republic, Argentina and Guatemala. Besides these, there is the Latin American and Caribbean scale, the scope of which is regional. The scales ranged from the standard reference used, number of questions and diagnosis of insecurity. The methods used by the studies for internal validation were calculation of Cronbach's alpha and the Rasch model; for external validation the authors calculated association and /or correlation with socioeconomic and food consumption variables. The successful experience of Latin America and the Caribbean in the development of national and regional scales can be an example for other countries that do not have this important indicator capable of measuring the phenomenon of food insecurity.

  17. Validation of Air-Backed Underwater Explosion Experiments with ALE3D

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Leininger, L D

    2005-02-04

    This paper summarizes an exercise carried out to validate the process of implementing LLNL's ALE3D to predict the permanent deformation and rupture of an air-backed steel plate subjected to underwater shock. Experiments were performed in a shock tank at the Naval Science and Technology Laboratory in Visakhapatnam India, and the results are documented in reference. A consistent set of air-backed plates is subjected to shocks from increasing weights of explosives ranging from 10g-80g. At 40g and above, rupture is recorded in the experiment and, without fracture mechanics implemented in ALE3D, only the cases of 10g, 20g, and 30g are presentedmore » here. This methodology applies the Jones-Wilkins-Lee (JWL) Equation of State (EOS) to predict the pressure of the expanding detonation products, the Gruneisein EOS for water under highly dynamic compressible flow - both on 1-point integrated 3-d continuum elements. The steel plates apply a bilinear elastic-plastic response with failure and are simulated with 3-point integrated shell elements. The failure for this exercise is based on effective (or equivalent) plastic strain.« less

  18. Testing and validating environmental models

    USGS Publications Warehouse

    Kirchner, J.W.; Hooper, R.P.; Kendall, C.; Neal, C.; Leavesley, G.

    1996-01-01

    Generally accepted standards for testing and validating ecosystem models would benefit both modellers and model users. Universally applicable test procedures are difficult to prescribe, given the diversity of modelling approaches and the many uses for models. However, the generally accepted scientific principles of documentation and disclosure provide a useful framework for devising general standards for model evaluation. Adequately documenting model tests requires explicit performance criteria, and explicit benchmarks against which model performance is compared. A model's validity, reliability, and accuracy can be most meaningfully judged by explicit comparison against the available alternatives. In contrast, current practice is often characterized by vague, subjective claims that model predictions show 'acceptable' agreement with data; such claims provide little basis for choosing among alternative models. Strict model tests (those that invalid models are unlikely to pass) are the only ones capable of convincing rational skeptics that a model is probably valid. However, 'false positive' rates as low as 10% can substantially erode the power of validation tests, making them insufficiently strict to convince rational skeptics. Validation tests are often undermined by excessive parameter calibration and overuse of ad hoc model features. Tests are often also divorced from the conditions under which a model will be used, particularly when it is designed to forecast beyond the range of historical experience. In such situations, data from laboratory and field manipulation experiments can provide particularly effective tests, because one can create experimental conditions quite different from historical data, and because experimental data can provide a more precisely defined 'target' for the model to hit. We present a simple demonstration showing that the two most common methods for comparing model predictions to environmental time series (plotting model time series

  19. A systematic review of the reliability and validity of discrete choice experiments in valuing non-market environmental goods.

    PubMed

    Rakotonarivo, O Sarobidy; Schaafsma, Marije; Hockley, Neal

    2016-12-01

    While discrete choice experiments (DCEs) are increasingly used in the field of environmental valuation, they remain controversial because of their hypothetical nature and the contested reliability and validity of their results. We systematically reviewed evidence on the validity and reliability of environmental DCEs from the past thirteen years (Jan 2003-February 2016). 107 articles met our inclusion criteria. These studies provide limited and mixed evidence of the reliability and validity of DCE. Valuation results were susceptible to small changes in survey design in 45% of outcomes reporting reliability measures. DCE results were generally consistent with those of other stated preference techniques (convergent validity), but hypothetical bias was common. Evidence supporting theoretical validity (consistency with assumptions of rational choice theory) was limited. In content validity tests, 2-90% of respondents protested against a feature of the survey, and a considerable proportion found DCEs to be incomprehensible or inconsequential (17-40% and 10-62% respectively). DCE remains useful for non-market valuation, but its results should be used with caution. Given the sparse and inconclusive evidence base, we recommend that tests of reliability and validity are more routinely integrated into DCE studies and suggest how this might be achieved. Copyright © 2016 The Authors. Published by Elsevier Ltd.. All rights reserved.

  20. Validation of an instrument to measure patients' experiences of medicine use: the Living with Medicines Questionnaire.

    PubMed

    Krska, Janet; Katusiime, Barbra; Corlett, Sarah A

    2017-01-01

    Medicine-related burden is an increasingly recognized concept, stemming from the rising tide of polypharmacy, which may impact on patient behaviors, including nonadherence. No instruments currently exist which specifically measure medicine-related burden. The Living with Medicines Questionnaire (LMQ) was developed for this purpose. This study validated the LMQ in a sample of adults using regular prescription medicines in the UK. Questionnaires were distributed in community pharmacies and public places in southeast England or online through UK health websites and social media. A total of 1,177 were returned: 507 (43.1%) from pharmacy distribution and 670 (56.9%) online. Construct validity was assessed by principal components analysis and item reduction undertaken on the original 60-item pool. Known-groups analysis assessed differences in mean total scores between participants using different numbers of medicines and between those who did or did not require assistance with medicine use. Internal consistency was assessed by Cronbach's alpha. Free-text comments were analyzed thematically to substantiate underlying dimensions. A 42-item, eight-factor structure comprising intercorrelated dimensions (patient-doctor relationships and communication about medicines, patient-pharmacist communication about medicines, interferences with daily life, practical difficulties, effectiveness, acceptance of medicine use, autonomy/control over medicines and concerns about medicine use) was derived, which explained 57.4% of the total variation. Six of the eight subscales had acceptable internal consistency (α>0.7). More positive experiences were observed among patients using eight or fewer medicines compared to nine or more, and those independent with managing/using their medicines versus those requiring assistance. Free-text comments, provided by almost a third of the respondents, supported the domains identified. The resultant LMQ-2 is a valid and reliable multidimensional measure of

  1. Preparing for the Validation Visit--Guidelines for Optimizing the Experience.

    ERIC Educational Resources Information Center

    Osborn, Hazel A.

    2003-01-01

    Urges child care programs to seek accreditation from NAEYC's National Academy of Early Childhood Programs to increase program quality and provides information on the validation process. Includes information on the validation visit and the validator's role and background. Offers suggestions for preparing the director, staff, children, and families…

  2. Design for validation: An approach to systems validation

    NASA Technical Reports Server (NTRS)

    Carter, William C.; Dunham, Janet R.; Laprie, Jean-Claude; Williams, Thomas; Howden, William; Smith, Brian; Lewis, Carl M. (Editor)

    1989-01-01

    Every complex system built is validated in some manner. Computer validation begins with review of the system design. As systems became too complicated for one person to review, validation began to rely on the application of adhoc methods by many individuals. As the cost of the changes mounted and the expense of failure increased, more organized procedures became essential. Attempts at devising and carrying out those procedures showed that validation is indeed a difficult technical problem. The successful transformation of the validation process into a systematic series of formally sound, integrated steps is necessary if the liability inherent in the future digita-system-based avionic and space systems is to be minimized. A suggested framework and timetable for the transformtion are presented. Basic working definitions of two pivotal ideas (validation and system life-cyle) are provided and show how the two concepts interact. Many examples are given of past and present validation activities by NASA and others. A conceptual framework is presented for the validation process. Finally, important areas are listed for ongoing development of the validation process at NASA Langley Research Center.

  3. The COSIMA experiments and their verification, a data base for the validation of two phase flow computer codes

    NASA Astrophysics Data System (ADS)

    Class, G.; Meyder, R.; Stratmanns, E.

    1985-12-01

    The large data base for validation and development of computer codes for two-phase flow, generated at the COSIMA facility, is reviewed. The aim of COSIMA is to simulate the hydraulic, thermal, and mechanical conditions in the subchannel and the cladding of fuel rods in pressurized water reactors during the blowout phase of a loss of coolant accident. In terms of fuel rod behavior, it is found that during blowout under realistic conditions only small strains are reached. For cladding rupture extremely high rod internal pressures are necessary. The behavior of fuel rod simulators and the effect of thermocouples attached to the cladding outer surface are clarified. Calculations performed with the codes RELAP and DRUFAN show satisfactory agreement with experiments. This can be improved by updating the phase separation models in the codes.

  4. Genome-wide analysis of adolescent psychotic-like experiences shows genetic overlap with psychiatric disorders.

    PubMed

    Pain, Oliver; Dudbridge, Frank; Cardno, Alastair G; Freeman, Daniel; Lu, Yi; Lundstrom, Sebastian; Lichtenstein, Paul; Ronald, Angelica

    2018-03-31

    This study aimed to test for overlap in genetic influences between psychotic-like experience traits shown by adolescents in the community, and clinically-recognized psychiatric disorders in adulthood, specifically schizophrenia, bipolar disorder, and major depression. The full spectra of psychotic-like experience domains, both in terms of their severity and type (positive, cognitive, and negative), were assessed using self- and parent-ratings in three European community samples aged 15-19 years (Final N incl. siblings = 6,297-10,098). A mega-genome-wide association study (mega-GWAS) for each psychotic-like experience domain was performed. Single nucleotide polymorphism (SNP)-heritability of each psychotic-like experience domain was estimated using genomic-relatedness-based restricted maximum-likelihood (GREML) and linkage disequilibrium- (LD-) score regression. Genetic overlap between specific psychotic-like experience domains and schizophrenia, bipolar disorder, and major depression was assessed using polygenic risk score (PRS) and LD-score regression. GREML returned SNP-heritability estimates of 3-9% for psychotic-like experience trait domains, with higher estimates for less skewed traits (Anhedonia, Cognitive Disorganization) than for more skewed traits (Paranoia and Hallucinations, Parent-rated Negative Symptoms). Mega-GWAS analysis identified one genome-wide significant association for Anhedonia within IDO2 but which did not replicate in an independent sample. PRS analysis revealed that the schizophrenia PRS significantly predicted all adolescent psychotic-like experience trait domains (Paranoia and Hallucinations only in non-zero scorers). The major depression PRS significantly predicted Anhedonia and Parent-rated Negative Symptoms in adolescence. Psychotic-like experiences during adolescence in the community show additive genetic effects and partly share genetic influences with clinically-recognized psychiatric disorders, specifically schizophrenia and

  5. Validating a large geophysical data set: Experiences with satellite-derived cloud parameters

    NASA Technical Reports Server (NTRS)

    Kahn, Ralph; Haskins, Robert D.; Knighton, James E.; Pursch, Andrew; Granger-Gallegos, Stephanie

    1992-01-01

    We are validating the global cloud parameters derived from the satellite-borne HIRS2 and MSU atmospheric sounding instrument measurements, and are using the analysis of these data as one prototype for studying large geophysical data sets in general. The HIRS2/MSU data set contains a total of 40 physical parameters, filling 25 MB/day; raw HIRS2/MSU data are available for a period exceeding 10 years. Validation involves developing a quantitative sense for the physical meaning of the derived parameters over the range of environmental conditions sampled. This is accomplished by comparing the spatial and temporal distributions of the derived quantities with similar measurements made using other techniques, and with model results. The data handling needed for this work is possible only with the help of a suite of interactive graphical and numerical analysis tools. Level 3 (gridded) data is the common form in which large data sets of this type are distributed for scientific analysis. We find that Level 3 data is inadequate for the data comparisons required for validation. Level 2 data (individual measurements in geophysical units) is needed. A sampling problem arises when individual measurements, which are not uniformly distributed in space or time, are used for the comparisons. Standard 'interpolation' methods involve fitting the measurements for each data set to surfaces, which are then compared. We are experimenting with formal criteria for selecting geographical regions, based upon the spatial frequency and variability of measurements, that allow us to quantify the uncertainty due to sampling. As part of this project, we are also dealing with ways to keep track of constraints placed on the output by assumptions made in the computer code. The need to work with Level 2 data introduces a number of other data handling issues, such as accessing data files across machine types, meeting large data storage requirements, accessing other validated data sets, processing speed

  6. Patient Experience Shows Little Relationship with Hospital Quality Management Strategies

    PubMed Central

    Groene, Oliver; Arah, Onyebuchi A.; Klazinga, Niek S.; Wagner, Cordula; Bartels, Paul D.; Kristensen, Solvejg; Saillour, Florence; Thompson, Andrew; Thompson, Caroline A.; Pfaff, Holger; DerSarkissian, Maral; Sunol, Rosa

    2015-01-01

    Objectives Patient-reported experience measures are increasingly being used to routinely monitor the quality of care. With the increasing attention on such measures, hospital managers seek ways to systematically improve patient experience across hospital departments, in particular where outcomes are used for public reporting or reimbursement. However, it is currently unclear whether hospitals with more mature quality management systems or stronger focus on patient involvement and patient-centered care strategies perform better on patient-reported experience. We assessed the effect of such strategies on a range of patient-reported experience measures. Materials and Methods We employed a cross-sectional, multi-level study design randomly recruiting hospitals from the Czech Republic, France, Germany, Poland, Portugal, Spain, and Turkey between May 2011 and January 2012. Each hospital contributed patient level data for four conditions/pathways: acute myocardial infarction, stroke, hip fracture and deliveries. The outcome variables in this study were a set of patient-reported experience measures including a generic 6-item measure of patient experience (NORPEQ), a 3-item measure of patient-perceived discharge preparation (Health Care Transition Measure) and two single item measures of perceived involvement in care and hospital recommendation. Predictor variables included three hospital management strategies: maturity of the hospital quality management system, patient involvement in quality management functions and patient-centered care strategies. We used directed acyclic graphs to detail and guide the modeling of the complex relationships between predictor variables and outcome variables, and fitted multivariable linear mixed models with random intercept by hospital, and adjusted for fixed effects at the country level, hospital level and patient level. Results Overall, 74 hospitals and 276 hospital departments contributed data on 6,536 patients to this study (acute

  7. Patient Experience Shows Little Relationship with Hospital Quality Management Strategies.

    PubMed

    Groene, Oliver; Arah, Onyebuchi A; Klazinga, Niek S; Wagner, Cordula; Bartels, Paul D; Kristensen, Solvejg; Saillour, Florence; Thompson, Andrew; Thompson, Caroline A; Pfaff, Holger; DerSarkissian, Maral; Sunol, Rosa

    2015-01-01

    Patient-reported experience measures are increasingly being used to routinely monitor the quality of care. With the increasing attention on such measures, hospital managers seek ways to systematically improve patient experience across hospital departments, in particular where outcomes are used for public reporting or reimbursement. However, it is currently unclear whether hospitals with more mature quality management systems or stronger focus on patient involvement and patient-centered care strategies perform better on patient-reported experience. We assessed the effect of such strategies on a range of patient-reported experience measures. We employed a cross-sectional, multi-level study design randomly recruiting hospitals from the Czech Republic, France, Germany, Poland, Portugal, Spain, and Turkey between May 2011 and January 2012. Each hospital contributed patient level data for four conditions/pathways: acute myocardial infarction, stroke, hip fracture and deliveries. The outcome variables in this study were a set of patient-reported experience measures including a generic 6-item measure of patient experience (NORPEQ), a 3-item measure of patient-perceived discharge preparation (Health Care Transition Measure) and two single item measures of perceived involvement in care and hospital recommendation. Predictor variables included three hospital management strategies: maturity of the hospital quality management system, patient involvement in quality management functions and patient-centered care strategies. We used directed acyclic graphs to detail and guide the modeling of the complex relationships between predictor variables and outcome variables, and fitted multivariable linear mixed models with random intercept by hospital, and adjusted for fixed effects at the country level, hospital level and patient level. Overall, 74 hospitals and 276 hospital departments contributed data on 6,536 patients to this study (acute myocardial infarction n = 1,379, hip fracture

  8. Measuring Educators' Attitudes and Beliefs about Evaluation: Construct Validity and Reliability of the Teacher Evaluation Experience Scale

    ERIC Educational Resources Information Center

    Reddy, Linda A.; Dudek, Christopher M.; Kettler, Ryan J.; Kurz, Alexander; Peters, Stephanie

    2016-01-01

    This study presents the reliability and validity of the Teacher Evaluation Experience Scale--Teacher Form (TEES-T), a multidimensional measure of educators' attitudes and beliefs about teacher evaluation. Confirmatory factor analyses of data from 583 teachers were conducted on the TEES-T hypothesized five-factor model, as well as on alternative…

  9. Shame, trauma, temperament and psychopathology: Construct validity of the Experience of Shame Scale.

    PubMed

    Vizin, Gabriella; Urbán, Róbert; Unoka, Zsolt

    2016-12-30

    Although Experience of Shame Scale (ESS) is used in clinical research and it covers psychiatrically relevant dimensions of chronic shame, characterological (CS), behavioral (BS) and bodily (BoS) respectively, its factor structures were not confirmed on clinical sample. The goals of our research were to examine the factor structure of the Hungarian version of ESS, in addition, to analyze the associations between factors of ESS and different types of predictors, such as clinical status, gender, age, school years, early abuse history, general psychopathology (GSI), and temperament dimensions by using a series of confirmatory factor analyses (CFA) with covariates in a large clinical and matched healthy sample. Psychiatric inpatients (N=148) and healthy control subjects (N=148) participated in this cross-sectional questionnaire study. In both samples, the degree of fit was adequate. The final CFA with covariates model showed significant and positive associations between CS and clinical status and education respectively, between CS, BS, BoS and frequency of verbal abuse, between CS and BoS and GSI and between CS and BS and harm avoidance and in addition we found negative associations between each of the shame factors and age. Our results support the psychiatric validity of the ESS construct. Copyright © 2016 Elsevier Ireland Ltd. All rights reserved.

  10. Measures of aggression and victimization in portuguese adolescents: Cross-cultural validation of the Revised Peer Experience Questionnaire.

    PubMed

    Queirós, Andreia N; Vagos, Paula

    2016-10-01

    The goal of this research was to develop and psychometrically evaluate the Portuguese version of the Revised Peer Experience Questionnaire, which assesses aggression, victimization and prosocial behavior. Victimization and aggression among adolescents in school settings is a growing problem, not yet fully understood or properly evaluated, particularly in Portugal. A sample of 1320 adolescents was recruited (52.7% female), with ages varying from 10 to 18 years old, attending middle and high school. Confirmatory factor analysis confirms the measurement model of the instrument's bully and victim versions, as evaluating overt, relational, and reputational aggression/victimization and providing/receiving prosocial behavior, respectively. This measurement model was invariant across schooling and gender, showed adequate internal consistency indicators, and presented evidence for construct validity in relation to other variables. Descriptive analyses indicate that boys are more aggressive in overt and relational forms and victimized through overt aggression, whereas girls are more aggressive and victimized relationally. More than any form of aggression or victimization, boys and girls revealed higher values for engaging in and receiving prosocial behavior. These results suggest that this instrument is a reliable, valid, and structurally sound measure of aggression, victimization and prosocial behavior in this Portuguese school-based community sample. Hence, its use may assist researchers in gaining a better understanding of adolescent aggression and victimization. (PsycINFO Database Record (c) 2016 APA, all rights reserved).

  11. The Development of the Functional Literacy Experience Scale Based upon Ecological Theory (FLESBUET) and Validity-Reliability Study

    ERIC Educational Resources Information Center

    Özenç, Emine Gül; Dogan, M. Cihangir

    2014-01-01

    This study aims to perform a validity-reliability test by developing the Functional Literacy Experience Scale based upon Ecological Theory (FLESBUET) for primary education students. The study group includes 209 fifth grade students at Sabri Taskin Primary School in the Kartal District of Istanbul, Turkey during the 2010-2011 academic year.…

  12. Validation of NOViSE.

    PubMed

    Korzeniowski, Przemyslaw; Brown, Daniel C; Sodergren, Mikael H; Barrow, Alastair; Bello, Fernando

    2017-02-01

    The goal of this study was to establish face, content, and construct validity of NOViSE-the first force-feedback enabled virtual reality (VR) simulator for natural orifice transluminal endoscopic surgery (NOTES). Fourteen surgeons and surgical trainees performed 3 simulated hybrid transgastric cholecystectomies using a flexible endoscope on NOViSE. Four of them were classified as "NOTES experts" who had independently performed 10 or more simulated or human NOTES procedures. Seven participants were classified as "Novices" and 3 as "Gastroenterologists" with no or minimal NOTES experience. A standardized 5-point Likert-type scale questionnaire was administered to assess the face and content validity. NOViSE showed good overall face and content validity. In 14 out of 15 statements pertaining to face validity (graphical appearance, endoscope and tissue behavior, overall realism), ≥50% of responses were "agree" or "strongly agree." In terms of content validity, 85.7% of participants agreed or strongly agreed that NOViSE is a useful training tool for NOTES and 71.4% that they would recommend it to others. Construct validity was established by comparing a number of performance metrics such as task completion times, path lengths, applied forces, and so on. NOViSE demonstrated early signs of construct validity. Experts were faster and used a shorter endoscopic path length than novices in all but one task. The results indicate that NOViSE authentically recreates a transgastric hybrid cholecystectomy and sets promising foundations for the further development of a VR training curriculum for NOTES without compromising patient safety or requiring expensive animal facilities.

  13. Culture Training: Validation Evidence for the Culture Assimilator.

    ERIC Educational Resources Information Center

    Mitchell, Terence R.; And Others

    The culture assimilator, a programed self-instructional approach to culture training, is described and a series of laboratory experiments and field studies validating the culture assimilator are reviewed. These studies show that the culture assimilator is an effective method of decreasing some of the stress experienced when one works with people…

  14. Validation of scintillometer measurements over a heterogeneous landscape: The LITFASS-2009 Experiment

    NASA Astrophysics Data System (ADS)

    Beyrich, F.; Bange, J.; Hartogensis, O.; Raasch, S.

    2009-09-01

    The turbulent exchange of heat and water vapour are essential land surface - atmosphere interaction processes in the local, regional and global energy and water cycles. Scintillometry can be considered as the only technique presently available for the quasi-operational experimental determination of area-averaged turbulent fluxes needed to validate the fluxes simulated by regional atmospheric models or derived from satellite images at a horizontal scale of a few kilometres. While scintillometry has found increasing application over the last years, some fundamental issues related to its use still need further investigation. In particular, no studies are known so far to reproduce the path-averaged structure parameters measured by scintillometers by independent measurements or modelling techniques. The LITFASS-2009 field experiment has been performed in the area around the Meteorological Observatory Lindenberg / Richard-Aßmann-Observatory in Germany during summer 2009. It was designed to investigate the spatial (horizontal and vertical) and temporal variability of structure parameters (underlying the scintillometer principle) over moderately heterogeneous terrain. The experiment essentially relied on a coupling of eddy-covariance measurements, scintillometry and airborne measurements with an unmanned autonomous aircraft able to strictly fly along the scintillometer path. Data interpretation will be supported by numerical modelling using a large-eddy simulation (LES) model. The paper will describe the design of the experiment. First preliminary results from the measurements will be presented.

  15. The Experience of Cognitive Intrusion of Pain: scale development and validation

    PubMed Central

    Attridge, Nina; Crombez, Geert; Van Ryckeghem, Dimitri; Keogh, Edmund; Eccleston, Christopher

    2015-01-01

    Abstract Patients with chronic pain often report their cognition to be impaired by pain, and this observation has been supported by numerous studies measuring the effects of pain on cognitive task performance. Furthermore, cognitive intrusion by pain has been identified as one of 3 components of pain anxiety, alongside general distress and fear of pain. Although cognitive intrusion is a critical characteristic of pain, no specific measure designed to capture its effects exists. In 3 studies, we describe the initial development and validation of a new measure of pain interruption: the Experience of Cognitive Intrusion of Pain (ECIP) scale. In study 1, the ECIP scale was administered to a general population sample to assess its structure and construct validity. In study 2, the factor structure of the ECIP scale was confirmed in a large general population sample experiencing no pain, acute pain, or chronic pain. In study 3, we examined the predictive value of the ECIP scale in pain-related disability in fibromyalgia patients. The ECIP scale scores followed a normal distribution with good variance in a general population sample. The scale had high internal reliability and a clear 1-component structure. It differentiated between chronic pain and control groups, and it was a significant predictor of pain-related disability over and above pain intensity. Repairing attentional interruption from pain may become a novel target for pain management interventions, both pharmacologic and nonpharmacologic. PMID:26067388

  16. Development and Validation of an Assessment Instrument for Course Experience in a General Education Integrated Science Course

    ERIC Educational Resources Information Center

    Liu, Juhong Christie; St. John, Kristen; Courtier, Anna M. Bishop

    2017-01-01

    Identifying instruments and surveys to address geoscience education research (GER) questions is among the high-ranked needs in a 2016 survey of the GER community (St. John et al., 2016). The purpose of this study was to develop and validate a student-centered assessment instrument to measure course experience in a general education integrated…

  17. CFD Validation Studies for Hypersonic Flow Prediction

    NASA Technical Reports Server (NTRS)

    Gnoffo, Peter A.

    2001-01-01

    A series of experiments to measure pressure and heating for code validation involving hypersonic, laminar, separated flows was conducted at the Calspan-University at Buffalo Research Center (CUBRC) in the Large Energy National Shock (LENS) tunnel. The experimental data serves as a focus for a code validation session but are not available to the authors until the conclusion of this session. The first set of experiments considered here involve Mach 9.5 and Mach 11.3 N2 flow over a hollow cylinder-flare with 30 degree flare angle at several Reynolds numbers sustaining laminar, separated flow. Truncated and extended flare configurations are considered. The second set of experiments, at similar conditions, involves flow over a sharp, double cone with fore-cone angle of 25 degrees and aft-cone angle of 55 degrees. Both sets of experiments involve 30 degree compressions. Location of the separation point in the numerical simulation is extremely sensitive to the level of grid refinement in the numerical predictions. The numerical simulations also show a significant influence of Reynolds number on extent of separation. Flow unsteadiness was easily introduced into the double cone simulations using aggressive relaxation parameters that normally promote convergence.

  18. CFD Validation Studies for Hypersonic Flow Prediction

    NASA Technical Reports Server (NTRS)

    Gnoffo, Peter A.

    2001-01-01

    A series of experiments to measure pressure and heating for code validation involving hypersonic, laminar, separated flows was conducted at the Calspan-University at Buffalo Research Center (CUBRC) in the Large Energy National Shock (LENS) tunnel. The experimental data serves as a focus for a code validation session but are not available to the authors until the conclusion of this session. The first set of experiments considered here involve Mach 9.5 and Mach 11.3 N, flow over a hollow cylinder-flare with 30 deg flare angle at several Reynolds numbers sustaining laminar, separated flow. Truncated and extended flare configurations are considered. The second set of experiments, at similar conditions, involves flow over a sharp, double cone with fore-cone angle of 25 deg and aft-cone angle of 55 deg. Both sets of experiments involve 30 deg compressions. Location of the separation point in the numerical simulation is extremely sensitive to the level of grid refinement in the numerical predictions. The numerical simulations also show a significant influence of Reynolds number on extent of separation. Flow unsteadiness was easily introduced into the double cone simulations using aggressive relaxation parameters that normally promote convergence.

  19. The ALICE Software Release Validation cluster

    NASA Astrophysics Data System (ADS)

    Berzano, D.; Krzewicki, M.

    2015-12-01

    One of the most important steps of software lifecycle is Quality Assurance: this process comprehends both automatic tests and manual reviews, and all of them must pass successfully before the software is approved for production. Some tests, such as source code static analysis, are executed on a single dedicated service: in High Energy Physics, a full simulation and reconstruction chain on a distributed computing environment, backed with a sample “golden” dataset, is also necessary for the quality sign off. The ALICE experiment uses dedicated and virtualized computing infrastructures for the Release Validation in order not to taint the production environment (i.e. CVMFS and the Grid) with non-validated software and validation jobs: the ALICE Release Validation cluster is a disposable virtual cluster appliance based on CernVM and the Virtual Analysis Facility, capable of deploying on demand, and with a single command, a dedicated virtual HTCondor cluster with an automatically scalable number of virtual workers on any cloud supporting the standard EC2 interface. Input and output data are externally stored on EOS, and a dedicated CVMFS service is used to provide the software to be validated. We will show how the Release Validation Cluster deployment and disposal are completely transparent for the Release Manager, who simply triggers the validation from the ALICE build system's web interface. CernVM 3, based entirely on CVMFS, permits to boot any snapshot of the operating system in time: we will show how this allows us to certify each ALICE software release for an exact CernVM snapshot, addressing the problem of Long Term Data Preservation by ensuring a consistent environment for software execution and data reprocessing in the future.

  20. Measuring women's childbirth experiences: a systematic review for identification and analysis of validated instruments.

    PubMed

    Nilvér, Helena; Begley, Cecily; Berg, Marie

    2017-06-29

    Women's childbirth experience can have immediate as well as long-term positive or negative effects on their life, well-being and health. When evaluating and drawing conclusions from research results, women's experiences of childbirth should be one aspect to consider. Researchers and clinicians need help in finding and selecting the most suitable instrument for their purpose. The aim of this study was therefore to systematically identify and present validated instruments measuring women's childbirth experience. A systematic review was conducted in January 2016 with a comprehensive search in the bibliographic databases PubMed, CINAHL, Scopus, The Cochrane Library and PsycINFO. Included instruments measured women's childbirth experiences. Papers were assessed independently by two reviewers for inclusion, and quality assessment of included instruments was made by two reviewers independently and in pairs using Terwee et al's criteria for evaluation of psychometric properties. In total 5189 citations were screened, of which 5106 were excluded by title and abstract. Eighty-three full-text papers were reviewed, and 37 papers were excluded, resulting in 46 included papers representing 36 instruments. These instruments demonstrated a wide range in purpose and content as well as in the quality of psychometric properties. This systematic review provides an overview of existing instruments measuring women's childbirth experiences and can support researchers to identify appropriate instruments to be used, and maybe adapted, in their specific contexts and research purpose.

  1. PSI-Center Validation Studies

    NASA Astrophysics Data System (ADS)

    Nelson, B. A.; Akcay, C.; Glasser, A. H.; Hansen, C. J.; Jarboe, T. R.; Marklin, G. J.; Milroy, R. D.; Morgan, K. D.; Norgaard, P. C.; Shumlak, U.; Sutherland, D. A.; Victor, B. S.; Sovinec, C. R.; O'Bryan, J. B.; Held, E. D.; Ji, J.-Y.; Lukin, V. S.

    2014-10-01

    The Plasma Science and Innovation Center (PSI-Center - http://www.psicenter.org) supports collaborating validation platform experiments with 3D extended MHD simulations using the NIMROD, HiFi, and PSI-TET codes. Collaborators include the Bellan Plasma Group (Caltech), CTH (Auburn U), HBT-EP (Columbia), HIT-SI (U Wash-UW), LTX (PPPL), MAST (Culham), Pegasus (U Wisc-Madison), SSX (Swarthmore College), TCSU (UW), and ZaP/ZaP-HD (UW). The PSI-Center is exploring application of validation metrics between experimental data and simulations results. Biorthogonal decomposition (BOD) is used to compare experiments with simulations. BOD separates data sets into spatial and temporal structures, giving greater weight to dominant structures. Several BOD metrics are being formulated with the goal of quantitive validation. Results from these simulation and validation studies, as well as an overview of the PSI-Center status will be presented.

  2. Offshore Radiation Observations for Climate Research at the CERES Ocean Validation Experiment

    NASA Technical Reports Server (NTRS)

    Rutledge, Charles K.; Schuster, Gregory L.; Charlock, Thomas P.; Denn, Frederick M.; Smith, William L., Jr.; Fabbri, Bryan E.; Madigan, James J., Jr.; Knapp, Robert J.

    2006-01-01

    When radiometers on a satellite are pointed towards the planet with the goal of understanding a phenomenon quantitatively, rather than just creating a pleasing image, the task at hand is often problematic. The signal at the detector can be affected by scattering, absorption, and emission; and these can be due to atmospheric constituents (gases, clouds, and aerosols), the earth's surface, and subsurface features. When targeting surface phenomena, the remote sensing algorithm needs to account for the radiation associated with the atmospheric constituents. Likewise, one needs to correct for the radiation leaving the surface, when atmospheric phenomena are of interest. Rigorous validation of such remote sensing products is a real challenge. In visible and near infrared wavelengths, the jumble of effects on atmospheric radiation are best accomplished over dark surfaces with fairly uniform reflective properties (spatial homogeneity) in the satellite instrument's field of view (FOV). The ocean's surface meets this criteria; land surfaces - which are brighter, more spatially inhomogeneous, and more changeable with time - generally do not. NASA's Clouds and the Earth's Radiant Energy System (CERES) project has used this backdrop to establish a radiation monitoring site in Virginia's coastal Atlantic Ocean. The project, called the CERES Ocean Validation Experiment (COVE), is located on a rigid ocean platform allowing the accurate measurement of radiation parameters that require precise leveling and pointing unavailable from ships or buoys. The COVE site is an optimal location for verifying radiative transfer models and remote sensing algorithms used in climate research; because of the platform's small size, there are no island wake effects; and suites of sensors can be simultaneously trained both on the sky and directly on ocean itself. This paper describes the site, the types of measurements made, multiple years of atmospheric and ocean surface radiation observations, and

  3. TU-D-201-05: Validation of Treatment Planning Dose Calculations: Experience Working with MPPG 5.a

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Xue, J; Park, J; Kim, L

    2016-06-15

    Purpose: Newly published medical physics practice guideline (MPPG 5.a.) has set the minimum requirements for commissioning and QA of treatment planning dose calculations. We present our experience in the validation of a commercial treatment planning system based on MPPG 5.a. Methods: In addition to tests traditionally performed to commission a model-based dose calculation algorithm, extensive tests were carried out at short and extended SSDs, various depths, oblique gantry angles and off-axis conditions to verify the robustness and limitations of a dose calculation algorithm. A comparison between measured and calculated dose was performed based on validation tests and evaluation criteria recommendedmore » by MPPG 5.a. An ion chamber was used for the measurement of dose at points of interest, and diodes were used for photon IMRT/VMAT validations. Dose profiles were measured with a three-dimensional scanning system and calculated in the TPS using a virtual water phantom. Results: Calculated and measured absolute dose profiles were compared at each specified SSD and depth for open fields. The disagreement is easily identifiable with the difference curve. Subtle discrepancy has revealed the limitation of the measurement, e.g., a spike at the high dose region and an asymmetrical penumbra observed on the tests with an oblique MLC beam. The excellent results we had (> 98% pass rate on 3%/3mm gamma index) on the end-to-end tests for both IMRT and VMAT are attributed to the quality beam data and the good understanding of the modeling. The limitation of the model and the uncertainty of measurement were considered when comparing the results. Conclusion: The extensive tests recommended by the MPPG encourage us to understand the accuracy and limitations of a dose algorithm as well as the uncertainty of measurement. Our experience has shown how the suggested tests can be performed effectively to validate dose calculation models.« less

  4. A CFD validation roadmap for hypersonic flows

    NASA Technical Reports Server (NTRS)

    Marvin, Joseph G.

    1992-01-01

    A roadmap for computational fluid dynamics (CFD) code validation is developed. The elements of the roadmap are consistent with air-breathing vehicle design requirements and related to the important flow path components: forebody, inlet, combustor, and nozzle. Building block and benchmark validation experiments are identified along with their test conditions and measurements. Based on an evaluation criteria, recommendations for an initial CFD validation data base are given and gaps identified where future experiments would provide the needed validation data.

  5. A CFD validation roadmap for hypersonic flows

    NASA Technical Reports Server (NTRS)

    Marvin, Joseph G.

    1993-01-01

    A roadmap for computational fluid dynamics (CFD) code validation is developed. The elements of the roadmap are consistent with air-breathing vehicle design requirements and related to the important flow path components: forebody, inlet, combustor, and nozzle. Building block and benchmark validation experiments are identified along with their test conditions and measurements. Based on an evaluation criteria, recommendations for an initial CFD validation data base are given and gaps identified where future experiments would provide the needed validation data.

  6. EOS Terra Validation Program

    NASA Technical Reports Server (NTRS)

    Starr, David

    1999-01-01

    The EOS Terra mission will be launched in July 1999. This mission has great relevance to the atmospheric radiation community and global change issues. Terra instruments include ASTER, CERES, MISR, MODIS and MOPITT. In addition to the fundamental radiance data sets, numerous global science data products will be generated, including various Earth radiation budget, cloud and aerosol parameters, as well as land surface, terrestrial ecology, ocean color, and atmospheric chemistry parameters. Significant investments have been made in on-board calibration to ensure the quality of the radiance observations. A key component of the Terra mission is the validation of the science data products. This is essential for a mission focused on global change issues and the underlying processes. The Terra algorithms have been subject to extensive pre-launch testing with field data whenever possible. Intensive efforts will be made to validate the Terra data products after launch. These include validation of instrument calibration (vicarious calibration) experiments, instrument and cross-platform comparisons, routine collection of high quality correlative data from ground-based networks, such as AERONET, and intensive sites, such as the SGP ARM site, as well as a variety field experiments, cruises, etc. Airborne simulator instruments have been developed for the field experiment and underflight activities including the MODIS Airborne Simulator (MAS), AirMISR, MASTER (MODIS-ASTER), and MOPITT-A. All are integrated on the NASA ER-2, though low altitude platforms are more typically used for MASTER. MATR is an additional sensor used for MOPITT algorithm development and validation. The intensive validation activities planned for the first year of the Terra mission will be described with emphasis on derived geophysical parameters of most relevance to the atmospheric radiation community. Detailed information about the EOS Terra validation Program can be found on the EOS Validation program

  7. Computational Design and Discovery of Ni-Based Alloys and Coatings: Thermodynamic Approaches Validated by Experiments

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Liu, Zi-Kui; Gleeson, Brian; Shang, Shunli

    This project developed computational tools that can complement and support experimental efforts in order to enable discovery and more efficient development of Ni-base structural materials and coatings. The project goal was reached through an integrated computation-predictive and experimental-validation approach, including first-principles calculations, thermodynamic CALPHAD (CALculation of PHAse Diagram), and experimental investigations on compositions relevant to Ni-base superalloys and coatings in terms of oxide layer growth and microstructure stabilities. The developed description included composition ranges typical for coating alloys and, hence, allow for prediction of thermodynamic properties for these material systems. The calculation of phase compositions, phase fraction, and phase stabilities,more » which are directly related to properties such as ductility and strength, was a valuable contribution, along with the collection of computational tools that are required to meet the increasing demands for strong, ductile and environmentally-protective coatings. Specifically, a suitable thermodynamic description for the Ni-Al-Cr-Co-Si-Hf-Y system was developed for bulk alloy and coating compositions. Experiments were performed to validate and refine the thermodynamics from the CALPHAD modeling approach. Additionally, alloys produced using predictions from the current computational models were studied in terms of their oxidation performance. Finally, results obtained from experiments aided in the development of a thermodynamic modeling automation tool called ESPEI/pycalphad - for more rapid discovery and development of new materials.« less

  8. Strain gauge validation experiments for the Sandia 34-meter VAWT (Vertical Axis Wind Turbine) test bed

    NASA Astrophysics Data System (ADS)

    Sutherland, Herbert J.

    1988-08-01

    Sandia National Laboratories has erected a research oriented, 34- meter diameter, Darrieus vertical axis wind turbine near Bushland, Texas. This machine, designated the Sandia 34-m VAWT Test Bed, is equipped with a large array of strain gauges that have been placed at critical positions about the blades. This manuscript details a series of four-point bend experiments that were conducted to validate the output of the blade strain gauge circuits. The output of a particular gauge circuit is validated by comparing its output to equivalent gauge circuits (in this stress state) and to theoretical predictions. With only a few exceptions, the difference between measured and predicted strain values for a gauge circuit was found to be of the order of the estimated repeatability for the measurement system.

  9. Validating the Patient Experience with Treatment and Self-Management (PETS), a patient-reported measure of treatment burden, in people with diabetes.

    PubMed

    Rogers, Elizabeth A; Yost, Kathleen J; Rosedahl, Jordan K; Linzer, Mark; Boehm, Deborah H; Thakur, Azra; Poplau, Sara; Anderson, Roger T; Eton, David T

    2017-01-01

    To validate a comprehensive general measure of treatment burden, the Patient Experience with Treatment and Self-Management (PETS), in people with diabetes. We conducted a secondary analysis of a cross-sectional survey study with 120 people diagnosed with type 1 or type 2 diabetes and at least one additional chronic illness. Surveys included established patient-reported outcome measures and a 48-item version of the PETS, a new measure comprised of multi-item scales assessing the burden of chronic illness treatment and self-care as it relates to nine domains: medical information, medications, medical appointments, monitoring health, interpersonal challenges, health care expenses, difficulty with health care services, role activity limitations, and physical/mental exhaustion from self-management. Internal reliability of PETS scales was determined using Cronbach's alpha. Construct validity was determined through correlation of PETS scores with established measures (measures of chronic condition distress, medication satisfaction, self-efficacy, and global well-being), and known-groups validity through comparisons of PETS scores across clinically distinct groups. In an exploratory test of predictive validity, step-wise regressions were used to determine which PETS scales were most associated with outcomes of chronic condition distress, overall physical and mental health, and medication adherence. Respondents were 37-88 years old, 59% female, 29% non-white, and 67% college-educated. PETS scales showed good reliability (Cronbach's alphas ≥0.74). Higher PETS scale scores (greater treatment burden) were correlated with more chronic condition distress, less medication convenience, lower self-efficacy, and worse general physical and mental health. Participants less (versus more) adherent to medications and those with more (versus fewer) health care financial difficulties had higher mean PETS scores. Medication burden was the scale that was most consistently associated with

  10. Empirical validation of an agent-based model of wood markets in Switzerland

    PubMed Central

    Hilty, Lorenz M.; Lemm, Renato; Thees, Oliver

    2018-01-01

    We present an agent-based model of wood markets and show our efforts to validate this model using empirical data from different sources, including interviews, workshops, experiments, and official statistics. Own surveys closed gaps where data was not available. Our approach to model validation used a variety of techniques, including the replication of historical production amounts, prices, and survey results, as well as a historical case study of a large sawmill entering the market and becoming insolvent only a few years later. Validating the model using this case provided additional insights, showing how the model can be used to simulate scenarios of resource availability and resource allocation. We conclude that the outcome of the rigorous validation qualifies the model to simulate scenarios concerning resource availability and allocation in our study region. PMID:29351300

  11. Measuring Black men's police-based discrimination experiences: Development and validation of the Police and Law Enforcement (PLE) Scale.

    PubMed

    English, Devin; Bowleg, Lisa; Del Río-González, Ana Maria; Tschann, Jeanne M; Agans, Robert P; Malebranche, David J

    2017-04-01

    Although social science research has examined police and law enforcement-perpetrated discrimination against Black men using policing statistics and implicit bias studies, there is little quantitative evidence detailing this phenomenon from the perspective of Black men. Consequently, there is a dearth of research detailing how Black men's perspectives on police and law enforcement-related stress predict negative physiological and psychological health outcomes. This study addresses these gaps with the qualitative development and quantitative test of the Police and Law Enforcement (PLE) Scale. In Study 1, we used thematic analysis on transcripts of individual qualitative interviews with 90 Black men to assess key themes and concepts and develop quantitative items. In Study 2, we used 2 focus groups comprised of 5 Black men each (n = 10), intensive cognitive interviewing with a separate sample of Black men (n = 15), and piloting with another sample of Black men (n = 13) to assess the ecological validity of the quantitative items. For Study 3, we analyzed data from a sample of 633 Black men between the ages of 18 and 65 to test the factor structure of the PLE, as we all as its concurrent validity and convergent/discriminant validity. Qualitative analyses and confirmatory factor analyses suggested that a 5-item, 1-factor measure appropriately represented respondents' experiences of police/law enforcement discrimination. As hypothesized, the PLE was positively associated with measures of racial discrimination and depressive symptoms. Preliminary evidence suggests that the PLE is a reliable and valid measure of Black men's experiences of discrimination with police/law enforcement. (PsycINFO Database Record (c) 2017 APA, all rights reserved).

  12. The Depressive Experiences Questionnaire: validity and psychological correlates in a clinical sample.

    PubMed

    Riley, W T; McCranie, E W

    1990-01-01

    This study sought to compare the original and revised scoring systems of the Depressive Experiences Questionnaire (DEQ) and to assess the construct validity of the Dependent and Self-Critical subscales of the DEQ in a clinically depressed sample. Subjects were 103 depressed inpatients who completed the DEQ, the Beck Depression Inventory (BDI), the Hopelessness Scale, the Automatic Thoughts Questionnaire (ATQ), the Rathus Assertiveness Schedule (RAS), and the Minnesota Multiphasic Personality Inventory (MMPI). The original and revised scoring systems of the DEQ evidenced good concurrent validity for each factor scale, but the revised system did not sufficiently discriminate dependent and self-critical dimensions. Using the original scoring system, self-criticism was significantly and positively related to severity of depression, whereas dependency was not, particularly for males. Factor analysis of the DEQ scales and the other scales used in this study supported the dependent and self-critical dimensions. For men, the correlation of the DEQ with the MMPI scales indicated that self-criticism was associated with psychotic symptoms, hostility/conflict, and a distress/exaggerated response set, whereas dependency did not correlate significantly with any MMPI scales. Females, however, did not exhibit a differential pattern of correlations between either the Dependency or the Self-Criticism scales and the MMPI. These findings suggest possible gender differences in the clinical characteristics of male and female dependent and self-critical depressive subtypes.

  13. Numerical studies and metric development for validation of magnetohydrodynamic models on the HIT-SI experiment

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Hansen, C., E-mail: hansec@uw.edu; Columbia University, New York, New York 10027; Victor, B.

    We present application of three scalar metrics derived from the Biorthogonal Decomposition (BD) technique to evaluate the level of agreement between macroscopic plasma dynamics in different data sets. BD decomposes large data sets, as produced by distributed diagnostic arrays, into principal mode structures without assumptions on spatial or temporal structure. These metrics have been applied to validation of the Hall-MHD model using experimental data from the Helicity Injected Torus with Steady Inductive helicity injection experiment. Each metric provides a measure of correlation between mode structures extracted from experimental data and simulations for an array of 192 surface-mounted magnetic probes. Numericalmore » validation studies have been performed using the NIMROD code, where the injectors are modeled as boundary conditions on the flux conserver, and the PSI-TET code, where the entire plasma volume is treated. Initial results from a comprehensive validation study of high performance operation with different injector frequencies are presented, illustrating application of the BD method. Using a simplified (constant, uniform density and temperature) Hall-MHD model, simulation results agree with experimental observation for two of the three defined metrics when the injectors are driven with a frequency of 14.5 kHz.« less

  14. Cultural Adaptation of the Portuguese Version of the “Sniffin’ Sticks” Smell Test: Reliability, Validity, and Normative Data

    PubMed Central

    Ribeiro, João Carlos; Simões, João; Silva, Filipe; Silva, Eduardo D.; Hummel, Cornelia; Hummel, Thomas; Paiva, António

    2016-01-01

    The cross-cultural adaptation and validation of the Sniffin`Sticks test for the Portuguese population is described. Over 270 people participated in four experiments. In Experiment 1, 67 participants rated the familiarity of presented odors and seven descriptors of the original test were adapted to a Portuguese context. In Experiment 2, the Portuguese version of Sniffin`Sticks test was administered to 203 healthy participants. Older age, male gender and active smoking status were confirmed as confounding factors. The third experiment showed the validity of the Portuguese version of Sniffin`Sticks test in discriminating healthy controls from patients with olfactory dysfunction. In Experiment 4, the test-retest reliability for both the composite score (r71 = 0.86) and the identification test (r71 = 0.62) was established (p<0.001). Normative data for the Portuguese version of Sniffin`Sticks test is provided, showing good validity and reliability and effectively distinguishing patients from healthy controls with high sensitivity and specificity. The Portuguese version of Sniffin`Sticks test identification test is a clinically suitable screening tool in routine outpatient Portuguese settings. PMID:26863023

  15. Comparison of airborne passive and active L-band System (PALS) brightness temperature measurements to SMOS observations during the SMAP validation experiment 2012 (SMAPVEX12)

    USDA-ARS?s Scientific Manuscript database

    The purpose of SMAP (Soil Moisture Active Passive) Validation Experiment 2012 (SMAPVEX12) campaign was to collect data for the pre-launch development and validation of SMAP soil moisture algorithms. SMAP is a National Aeronautics and Space Administration’s (NASA) satellite mission designed for the m...

  16. Integration and Test Flight Validation Plans for the Pulsed Plasma Thruster Experiment on EO- 1

    NASA Technical Reports Server (NTRS)

    Zakrzwski, Charles; Benson, Scott; Sanneman, Paul; Hoskins, Andy; Bauer, Frank H. (Technical Monitor)

    2002-01-01

    The Pulsed Plasma Thruster (PPT) Experiment on the Earth Observing One (EO-1) spacecraft has been designed to demonstrate the capability of a new generation PPT to perform spacecraft attitude control. The PPT is a small, self-contained pulsed electromagnetic propulsion system capable of delivering high specific impulse (900-1200 s), very small impulse bits (10-1000 uN-s) at low average power (less than 1 to 100 W). Teflon fuel is ablated and slightly ionized by means of a capacitative discharge. The discharge also generates electromagnetic fields that accelerate the plasma by means of the Lorentz Force. EO-1 has a single PPT that can produce thrust in either the positive or negative pitch direction. The flight validation has been designed to demonstrate of the ability of the PPT to provide precision pointing accuracy, response and stability, and confirmation of benign plume and EMI effects. This paper will document the success of the flight validation.

  17. Factor Analysis of the Mystical Experience Questionnaire: A Study of Experiences Occasioned by the Hallucinogen Psilocybin

    PubMed Central

    Maclean, Katherine A.; Leoutsakos, Jeannie-Marie S.; Johnson, Matthew W.; Griffiths, Roland R.

    2012-01-01

    A large body of historical evidence describes the use of hallucinogenic compounds, such as psilocybin mushrooms, for religious purposes. But few scientific studies have attempted to measure or characterize hallucinogen-occasioned spiritual experiences. The present study examined the factor structure of the Mystical Experience Questionnaire (MEQ), a self-report measure that has been used to assess the effects of hallucinogens in laboratory studies. Participants (N=1602) completed the 43-item MEQ in reference to a mystical or profound experience they had had after ingesting psilocybin. Exploratory factor analysis of the MEQ retained 30 items and revealed a 4-factor structure covering the dimensions of classic mystical experience: unity, noetic quality, sacredness (F1); positive mood (F2); transcendence of time/space (F3); and ineffability (F4). MEQ factor scores showed good internal reliability and correlated with the Hood Mysticism Scale, indicating convergent validity. Participants who endorsed having had a mystical experience on psilocybin, compared to those who did not, had significantly higher factor scores, indicating construct validity. The 4-factor structure was confirmed in a second sample (N=440) and demonstrated superior fit compared to alternative models. The results provide initial evidence of the validity, reliability, and factor structure of a 30-item scale for measuring single, hallucinogen-occasioned mystical experiences, which may be a useful tool in the scientific study of mysticism. PMID:23316089

  18. Measuring Black Men’s Police-Based Discrimination Experiences: Development and Validation of the Police and Law Enforcement (PLE) Scale

    PubMed Central

    English, Devin; Bowleg, Lisa; del Río-González, Ana Maria; Tschann, Jeanne M.; Agans, Robert; Malebranche, David J

    2017-01-01

    Objectives Although social science research has examined police and law enforcement-perpetrated discrimination against Black men using policing statistics and implicit bias studies, there is little quantitative evidence detailing this phenomenon from the perspective of Black men. Consequently, there is a dearth of research detailing how Black men’s perspectives on police and law enforcement-related stress predict negative physiological and psychological health outcomes. This study addresses these gaps with the qualitative development and quantitative test of the Police and Law Enforcement (PLE) scale. Methods In Study 1, we employed thematic analysis on transcripts of individual qualitative interviews with 90 Black men to assess key themes and concepts and develop quantitative items. In Study 2, we used 2 focus groups comprised of 5 Black men each (n=10), intensive cognitive interviewing with a separate sample of Black men (n=15), and piloting with another sample of Black men (n=13) to assess the ecological validity of the quantitative items. For study 3, we analyzed data from a sample of 633 Black men between the ages of 18 and 65 to test the factor structure of the PLE, as we all as its concurrent validity and convergent/discriminant validity. Results Qualitative analyses and confirmatory factor analyses suggested that a 5-item, 1-factor measure appropriately represented respondents’ experiences of police/law enforcement discrimination. As hypothesized, the PLE was positively associated with measures of racial discrimination and depressive symptoms. Conclusions Preliminary evidence suggests that the PLE is a reliable and valid measure of Black men’s experiences of discrimination with police/law enforcement. PMID:28080104

  19. Inner experience in the scanner: can high fidelity apprehensions of inner experience be integrated with fMRI?

    PubMed Central

    Kühn, Simone; Fernyhough, Charles; Alderson-Day, Benjamin; Hurlburt, Russell T.

    2014-01-01

    To provide full accounts of human experience and behavior, research in cognitive neuroscience must be linked to inner experience, but introspective reports of inner experience have often been found to be unreliable. The present case study aimed at providing proof of principle that introspection using one method, descriptive experience sampling (DES), can be reliably integrated with fMRI. A participant was trained in the DES method, followed by nine sessions of sampling within an MRI scanner. During moments where the DES interview revealed ongoing inner speaking, fMRI data reliably showed activation in classic speech processing areas including left inferior frontal gyrus. Further, the fMRI data validated the participant’s DES observations of the experiential distinction between inner speaking and innerly hearing her own voice. These results highlight the precision and validity of the DES method as a technique of exploring inner experience and the utility of combining such methods with fMRI. PMID:25538649

  20. Disturbance Reduction Control Design for the ST7 Flight Validation Experiment

    NASA Technical Reports Server (NTRS)

    Maghami, P. G.; Hsu, O. C.; Markley, F. L.; Houghton, M. B.

    2003-01-01

    The Space Technology 7 experiment will perform an on-orbit system-level validation of two specific Disturbance Reduction System technologies: a gravitational reference sensor employing a free-floating test mass, and a set of micro-Newton colloidal thrusters. The ST7 Disturbance Reduction System is designed to maintain the spacecraft's position with respect to a free-floating test mass to less than 10 nm/Hz, over the frequency range of 1 to 30 mHz. This paper presents the design and analysis of the coupled, drag-free and attitude control systems that close the loop between the gravitational reference sensor and the micro-Newton thrusters, while incorporating star tracker data at low frequencies. A full 18 degree-of-freedom model, which incorporates rigid-body models of the spacecraft and two test masses, is used to evaluate the effects of actuation and measurement noise and disturbances on the performance of the drag-free system.

  1. Analysis and Ground Testing for Validation of the Inflatable Sunshield in Space (ISIS) Experiment

    NASA Technical Reports Server (NTRS)

    Lienard, Sebastien; Johnston, John; Adams, Mike; Stanley, Diane; Alfano, Jean-Pierre; Romanacci, Paolo

    2000-01-01

    The Next Generation Space Telescope (NGST) design requires a large sunshield to protect the large aperture mirror and instrument module from constant solar exposure at its L2 orbit. The structural dynamics of the sunshield must be modeled in order to predict disturbances to the observatory attitude control system and gauge effects on the line of site jitter. Models of large, non-linear membrane systems are not well understood and have not been successfully demonstrated. To answer questions about sunshield dynamic behavior and demonstrate controlled deployment, the NGST project is flying a Pathfinder experiment, the Inflatable Sunshield in Space (ISIS). This paper discusses in detail the modeling and ground-testing efforts performed at the Goddard Space Flight Center to: validate analytical tools for characterizing the dynamic behavior of the deployed sunshield, qualify the experiment for the Space Shuttle, and verify the functionality of the system. Included in the discussion will be test parameters, test setups, problems encountered, and test results.

  2. Use of the recognition heuristic depends on the domain's recognition validity, not on the recognition validity of selected sets of objects.

    PubMed

    Pohl, Rüdiger F; Michalkiewicz, Martha; Erdfelder, Edgar; Hilbig, Benjamin E

    2017-07-01

    According to the recognition-heuristic theory, decision makers solve paired comparisons in which one object is recognized and the other not by recognition alone, inferring that recognized objects have higher criterion values than unrecognized ones. However, success-and thus usefulness-of this heuristic depends on the validity of recognition as a cue, and adaptive decision making, in turn, requires that decision makers are sensitive to it. To this end, decision makers could base their evaluation of the recognition validity either on the selected set of objects (the set's recognition validity), or on the underlying domain from which the objects were drawn (the domain's recognition validity). In two experiments, we manipulated the recognition validity both in the selected set of objects and between domains from which the sets were drawn. The results clearly show that use of the recognition heuristic depends on the domain's recognition validity, not on the set's recognition validity. In other words, participants treat all sets as roughly representative of the underlying domain and adjust their decision strategy adaptively (only) with respect to the more general environment rather than the specific items they are faced with.

  3. Validating a driving simulator using surrogate safety measures.

    PubMed

    Yan, Xuedong; Abdel-Aty, Mohamed; Radwan, Essam; Wang, Xuesong; Chilakapati, Praveen

    2008-01-01

    Traffic crash statistics and previous research have shown an increased risk of traffic crashes at signalized intersections. How to diagnose safety problems and develop effective countermeasures to reduce crash rate at intersections is a key task for traffic engineers and researchers. This study aims at investigating whether the driving simulator can be used as a valid tool to assess traffic safety at signalized intersections. In support of the research objective, this simulator validity study was conducted from two perspectives, a traffic parameter (speed) and a safety parameter (crash history). A signalized intersection with as many important features (including roadway geometries, traffic control devices, intersection surroundings, and buildings) was replicated into a high-fidelity driving simulator. A driving simulator experiment with eight scenarios at the intersection were conducted to determine if the subjects' speed behavior and traffic risk patterns in the driving simulator were similar to what were found at the real intersection. The experiment results showed that speed data observed from the field and in the simulator experiment both follow normal distributions and have equal means for each intersection approach, which validated the driving simulator in absolute terms. Furthermore, this study used an innovative approach of using surrogate safety measures from the simulator to contrast with the crash analysis for the field data. The simulator experiment results indicated that compared to the right-turn lane with the low rear-end crash history record (2 crashes), subjects showed a series of more risky behaviors at the right-turn lane with the high rear-end crash history record (16 crashes), including higher deceleration rate (1.80+/-1.20 m/s(2) versus 0.80+/-0.65 m/s(2)), higher non-stop right-turn rate on red (81.67% versus 57.63%), higher right-turn speed as stop line (18.38+/-8.90 km/h versus 14.68+/-6.04 km/h), shorter following distance (30

  4. Development and Validation of an Internet Use Attitude Scale

    ERIC Educational Resources Information Center

    Zhang, Yixin

    2007-01-01

    This paper describes the development and validation of a new 40-item Internet Attitude Scale (IAS), a one-dimensional inventory for measuring the Internet attitudes. The first experiment initiated a generic Internet attitude questionnaire, ensured construct validity, and examined factorial validity and reliability. The second experiment further…

  5. Development and initial validation of the Parental PELICAN Questionnaire (PaPEQu)--an instrument to assess parental experiences and needs during their child's end-of-life care.

    PubMed

    Zimmermann, Karin; Cignacco, Eva; Eskola, Katri; Engberg, Sandra; Ramelet, Anne-Sylvie; Von der Weid, Nicolas; Bergstraesser, Eva

    2015-12-01

    To develop and test the Parental PELICAN Questionnaire, an instrument to retrospectively assess parental experiences and needs during their child's end-of-life care. To offer appropriate care for dying children, healthcare professionals need to understand the illness experience from the family perspective. A questionnaire specific to the end-of-life experiences and needs of parents losing a child is needed to evaluate the perceived quality of paediatric end-of-life care. This is an instrument development study applying mixed methods based on recommendations for questionnaire design and validation. The Parental PELICAN Questionnaire was developed in four phases between August 2012-March 2014: phase 1: item generation; phase 2: validity testing; phase 3: translation; phase 4: pilot testing. Psychometric properties were assessed after applying the Parental PELICAN Questionnaire in a sample of 224 bereaved parents in April 2014. Validity testing covered the evidence based on tests of content, internal structure and relations to other variables. The Parental PELICAN Questionnaire consists of approximately 90 items in four slightly different versions accounting for particularities of the four diagnostic groups. The questionnaire's items were structured according to six quality domains described in the literature. Evidence of initial validity and reliability could be demonstrated with the involvement of healthcare professionals and bereaved parents. The Parental PELICAN Questionnaire holds promise as a measure to assess parental experiences and needs and is applicable to a broad range of paediatric specialties and settings. Future validation is needed to evaluate its suitability in different cultures. © 2015 John Wiley & Sons Ltd.

  6. Development and Initial Validation of the Pain Resilience Scale.

    PubMed

    Slepian, P Maxwell; Ankawi, Brett; Himawan, Lina K; France, Christopher R

    2016-04-01

    Over the past decade, the role of positive psychology in pain experience has gained increasing attention. One such positive factor, identified as resilience, has been defined as the ability to maintain positive emotional and physical functioning despite physical or psychological adversity. Although cross-situational measures of resilience have been shown to be related to pain, it was hypothesized that a pain-specific resilience measure would serve as a stronger predictor of acute pain experience. To test this hypothesis, we conducted a series of studies to develop and validate the Pain Resilience Scale. Study 1 described exploratory and confirmatory factor analyses that support a scale with 2 distinct factors, Cognitive/Affective Positivity and Behavioral Perseverance. Study 2 showed test-retest reliability and construct validity of this new scale, including moderate positive relationships with measures of positive psychological functioning and small to moderate negative relationships with vulnerability measures such as pain catastrophizing. Finally, consistent with our initial hypothesis, study 3 showed that the Pain Resilience Scale is more strongly related to ischemic pain responses than existing measures of general resilience. Together, these studies support the predictive utility of this new pain-specific measure of resilience in the context of acute experimental pain. The Pain Resilience Scale represents a novel measure of Cognitive/Affective Positivity and Behavioral Perseverance during exposure to noxious stimuli. Construct validity is supported by expected relationships with existing pain-coping measures, and predictive validity is shown by individual differences in response to acute experimental pain. Copyright © 2016 American Pain Society. Published by Elsevier Inc. All rights reserved.

  7. Upwelling Measurement Issues at the CERES Ocean Validation Experiment (COVE)

    NASA Astrophysics Data System (ADS)

    Fabbri, B. E.; Schuster, G. L.; Denn, F. M.; Arduini, R. F.; Madigan, J. J.; Rutan, D. A.

    2016-12-01

    The Clouds and the Earth's Radiant Energy System (CERES) satellite measures both solar-reflected and Earth-emitted radiation from the Earth's surface to the top of the atmosphere. One surface validation site is located at Chesapeake Light Station, approximately 25 kilometers east of Virginia Beach, Virginia (coordinates: 36.90N, 75.71W). In 1999, the CERES Ocean Validation Experiment (COVE) was established at Chesapeake Light Station. COVE is in its 17th year collecting radiometric and meteorological data. Other measurements over this time period include aerosol optical depth, water leaving radiance, precipitable water vapor and more. The issues we are trying to resolve for the upwelling flux are two-fold. First, there is the "shadow effect". In the morning, the shadow of the tower appears on the water in the field of view underneath the shortwave (SW) and longwave (LW) upwelling instruments. An attempt to understand the shading effect is made by separating the data into "shaded" and "unshaded" time periods using the Solar Azimuth (SA) angle. SA < 180 degrees are considered shaded, and SA > 180 degrees are considered unshaded. Upwelling SW shaded and unshaded datasets differ by a maximum of 9.5 W/m2 and a minimum of -0.7 W/m2 with the delta mean resulting in 3.6 W/m2. Upwelling LW shaded and unshaded datasets differ by a maximum of 8.0 W/m2 and a minimum of 1.0 W/m2 with the delta mean resulting in 3.7 W/m2. The second issue is the "tower radiating effect" which is especially noticeable on clear, sunny days. During these days, the tower tends to heat up and radiate extra heat energy that is measured by the LW instrument. We compare Infrared Radiation Thermometer (IRT) measurements to Precision Infrared Radiometer (PIR) measurements and make a case for using IRT measurements as upwelling LW.

  8. EXCALIBUR-at-CALIBAN: a neutron transmission experiment for {sup 238}U(n,n'{sub continuum}γ) nuclear data validation

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Bernard, David; Leconte, Pierre; Destouches, Christophe

    2015-07-01

    Two recent papers justified a new experimental program to give a new basis for the validation of {sup 238}U nuclear data, namely neutron induced inelastic scattering and transport codes at neutron fission energies. The general idea is to perform a neutron transmission experiment through natural uranium material. As shown by Hans Bethe, neutron transmissions measured by dosimetric responses are linked to inelastic cross sections. This paper describes the principle and the results of such an experience called EXCALIBUR performed recently (January and October 2014) at the CALIBAN reactor facility. (authors)

  9. Validating the Patient Experience with Treatment and Self-Management (PETS), a patient-reported measure of treatment burden, in people with diabetes

    PubMed Central

    Rogers, Elizabeth A; Yost, Kathleen J; Rosedahl, Jordan K; Linzer, Mark; Boehm, Deborah H; Thakur, Azra; Poplau, Sara; Anderson, Roger T; Eton, David T

    2017-01-01

    Aims To validate a comprehensive general measure of treatment burden, the Patient Experience with Treatment and Self-Management (PETS), in people with diabetes. Methods We conducted a secondary analysis of a cross-sectional survey study with 120 people diagnosed with type 1 or type 2 diabetes and at least one additional chronic illness. Surveys included established patient-reported outcome measures and a 48-item version of the PETS, a new measure comprised of multi-item scales assessing the burden of chronic illness treatment and self-care as it relates to nine domains: medical information, medications, medical appointments, monitoring health, interpersonal challenges, health care expenses, difficulty with health care services, role activity limitations, and physical/mental exhaustion from self-management. Internal reliability of PETS scales was determined using Cronbach’s alpha. Construct validity was determined through correlation of PETS scores with established measures (measures of chronic condition distress, medication satisfaction, self-efficacy, and global well-being), and known-groups validity through comparisons of PETS scores across clinically distinct groups. In an exploratory test of predictive validity, step-wise regressions were used to determine which PETS scales were most associated with outcomes of chronic condition distress, overall physical and mental health, and medication adherence. Results Respondents were 37–88 years old, 59% female, 29% non-white, and 67% college-educated. PETS scales showed good reliability (Cronbach’s alphas ≥0.74). Higher PETS scale scores (greater treatment burden) were correlated with more chronic condition distress, less medication convenience, lower self-efficacy, and worse general physical and mental health. Participants less (versus more) adherent to medications and those with more (versus fewer) health care financial difficulties had higher mean PETS scores. Medication burden was the scale that was most

  10. Community males show multiple-perpetrator rape proclivity: development and preliminary validation of an interest scale.

    PubMed

    Alleyne, Emma; Gannon, Theresa A; Ó Ciardha, Caoilte; Wood, Jane L

    2014-02-01

    The literature on Multiple Perpetrator Rape (MPR) is scant; however, a significant proportion of sexual offending involves multiple perpetrators. In addition to the need for research with apprehended offenders of MPR, there is also a need to conduct research with members of the general public. Recent advances in the forensic literature have led to the development of self-report proclivity scales. These scales have enabled researchers to conduct evaluative studies sampling from members of the general public who may be perpetrators of sexual offenses and have remained undetected, or at highest risk of engaging in sexual offending. The current study describes the development and preliminary validation of the Multiple-Perpetrator Rape Interest Scale (M-PRIS), a vignette-based measure assessing community males' sexual arousal to MPR, behavioral propensity toward MPR and enjoyment of MPR. The findings show that the M-PRIS is a reliable measure of community males' sexual interest in MPR with high internal reliability and temporal stability. In a sample of university males we found that a large proportion (66%) did not emphatically reject an interest in MPR. We also found that rape-supportive cognitive distortions, antisocial attitudes, and high-risk sexual fantasies were predictors of sexual interest in MPR. We discuss these findings and the implications for further research employing proclivity measures referencing theory development and clinical practice.

  11. Linguistic and content validation of a German-language PRO-CTCAE-based patient-reported outcomes instrument to evaluate the late effect symptom experience after allogeneic hematopoietic stem cell transplantation.

    PubMed

    Kirsch, Monika; Mitchell, Sandra A; Dobbels, Fabienne; Stussi, Georg; Basch, Ethan; Halter, Jorg P; De Geest, Sabina

    2015-02-01

    The aim of this sequential mixed methods study was to develop a PRO-CTCAE (Patient-Reported Outcomes version of the Common Terminology Criteria for Adverse Events)-based measure of the symptom experience of late effects in German speaking long-term survivors of allogeneic stem cell transplantation (SCT), and to examine its content validity. The US National Cancer Institute's PRO-CTAE item library was translated into German and linguistically validated. PRO-CTCAE symptoms prevalent in ≥50% of survivors (n = 15) and recognized in its importance by SCT experts (n = 9) were identified. Additional concepts relevant to the symptom experience and its consequences were elicited. Content validity of the PROVIVO (Patient-Reported Outcomes of long-term survivors after allogeneic SCT) instrument was assessed through an additional round of cognitive debriefing in 15 patients, and item and scale content validity indices by 9 experts. PROVIVO is comprised of a total of 49 items capturing the experience of physical, emotional and cognitive symptoms. To improve the instrument's utility for clinical decision-making, questions soliciting limitations in activities of daily living, frequent infections, and overall well-being were added. Cognitive debriefings demonstrated that items were well understood and relevant to the SCT survivor experience. Scale Content Validity Index (CVI) (0.94) and item CVI (median = 1; range 0.75-1) were very high. Qualitative and quantitative data provide preliminary evidence supporting the content validity of PROVIVO and identify a PRO-CTCAE item bundle for use in SCT survivors. A study to evaluate the measurement properties of PROVIVO and to examine its capacity to improve survivorship care planning is underway. Copyright © 2014 Elsevier Ltd. All rights reserved.

  12. The other side of recovery: validation of the Portuguese version of the subjective experiences of psychosis scale.

    PubMed

    Martins, Filipa; Soares, Sandra C; Bem-Haja, Pedro; Roque, Carolina; Madeira, Nuno

    2015-10-14

    The aim of this study was to develop and validate a Portuguese version of The Subjective Experiences of Psychosis Scale (SEPS) for use in Portuguese-speaking populations in order to provide a self-report instrument to assess and monitor dimensions of psychotic experiences, translating patient's perspective and experience in terms of recovery from psychosis. The sample consisted of 30 participants with psychotic disorders who had recently experienced delusions or hallucinations. The SEPS was completed along with other observer-based assessments and self-report questionnaires, such as the Brief Psychiatric Rating Scale, the Insight and Treatment Attitudes Questionnaire and the Function Assessment Short Test. Two main factors representing the positive and negative components of each subscale were identified. We obtained good internal consistency and test-retest reliability for the positive and negative components of all subscales. The subscales of SEPS correlated with observer-based assessments and self-report questionnaires. The Portuguese version of the SEPS is a useful tool in the assessment and monitoring of psychotic symptoms.

  13. Assessing students' communication skills: validation of a global rating.

    PubMed

    Scheffer, Simone; Muehlinghaus, Isabel; Froehmel, Annette; Ortwein, Heiderose

    2008-12-01

    Communication skills training is an accepted part of undergraduate medical programs nowadays. In addition to learning experiences its importance should be emphasised by performance-based assessment. As detailed checklists have been shown to be not well suited for the assessment of communication skills for different reasons, this study aimed to validate a global rating scale. A Canadian instrument was translated to German and adapted to assess students' communication skills during an end-of-semester-OSCE. Subjects were second and third year medical students at the reformed track of the Charité-Universitaetsmedizin Berlin. Different groups of raters were trained to assess students' communication skills using the global rating scale. Validity testing included concurrent validity and construct validity: Judgements of different groups of raters were compared to expert ratings as a defined gold standard. Furthermore, the amount of agreement between scores obtained with this global rating scale and a different instrument for assessing communication skills was determined. Results show that communication skills can be validly assessed by trained non-expert raters as well as standardised patients using this instrument.

  14. A field experiment shows that subtle linguistic cues might not affect voter behavior

    PubMed Central

    Gerber, Alan S.; Biggers, Daniel R.; Hendry, David J.

    2016-01-01

    One of the most important recent developments in social psychology is the discovery of minor interventions that have large and enduring effects on behavior. A leading example of this class of results is in the work by Bryan et al. [Bryan CJ, Walton GM, Rogers T, Dweck CS (2011) Proc Natl Acad Sci USA 108(31):12653–12656], which shows that administering a set of survey items worded so that subjects think of themselves as voters (noun treatment) rather than as voting (verb treatment) substantially increases political participation (voter turnout) among subjects. We revisit these experiments by replicating and extending their research design in a large-scale field experiment. In contrast to the 11 to 14% point greater turnout among those exposed to the noun rather than the verb treatment reported in the work by Bryan et al., we find no statistically significant difference in turnout between the noun and verb treatments (the point estimate of the difference is approximately zero). Furthermore, when we benchmark these treatments against a standard get out the vote message, we estimate that both are less effective at increasing turnout than a much shorter basic mobilization message. In our conclusion, we detail how our study differs from the work by Bryan et al. and discuss how our results might be interpreted. PMID:27298362

  15. A field experiment shows that subtle linguistic cues might not affect voter behavior.

    PubMed

    Gerber, Alan S; Huber, Gregory A; Biggers, Daniel R; Hendry, David J

    2016-06-28

    One of the most important recent developments in social psychology is the discovery of minor interventions that have large and enduring effects on behavior. A leading example of this class of results is in the work by Bryan et al. [Bryan CJ, Walton GM, Rogers T, Dweck CS (2011) Proc Natl Acad Sci USA 108(31):12653-12656], which shows that administering a set of survey items worded so that subjects think of themselves as voters (noun treatment) rather than as voting (verb treatment) substantially increases political participation (voter turnout) among subjects. We revisit these experiments by replicating and extending their research design in a large-scale field experiment. In contrast to the 11 to 14% point greater turnout among those exposed to the noun rather than the verb treatment reported in the work by Bryan et al., we find no statistically significant difference in turnout between the noun and verb treatments (the point estimate of the difference is approximately zero). Furthermore, when we benchmark these treatments against a standard get out the vote message, we estimate that both are less effective at increasing turnout than a much shorter basic mobilization message. In our conclusion, we detail how our study differs from the work by Bryan et al. and discuss how our results might be interpreted.

  16. Convergent Validity of the Early Memory Index in Two Primary Care Samples.

    PubMed

    Porcerelli, John H; Cogan, Rosemary; Melchior, Katherine A; Jasinski, Matthew J; Richardson, Laura; Fowler, Shannon; Morris, Pierre; Murdoch, William

    2016-01-01

    Karliner, Westrich, Shedler, and Mayman (1996) developed the Early Memory Index (EMI) to assess mental health, narrative coherence, and traumatic experiences in reports of early memories. We assessed the convergent validity of EMI scales with data from 103 women from an urban primary care clinic (Study 1) and data from 48 women and 24 men from a suburban primary care clinic (Study 2). Patients provided early memory narratives and completed self-report measures of psychopathology, trauma, and health care utilization. In both studies, lower scores on the Mental Health scale and higher scores on the Traumatic Experiences scale were related to higher scores on measures of psychopathology and childhood trauma. Less consistent associations were found between the Mental Health and Traumatic Experiences scores and measures of health care utilization. The Narrative Coherence scale showed inconsistent relationships across measures in both samples. In analyses assessing the overall fit between hypothesized and actual correlations between EMI scores and measures of psychopathology, severity of trauma symptoms, and health care utilization, the Mental Health scale of the EMI demonstrated stronger convergent validity than the EMI Traumatic Experiences scale. The results provide support for the convergent validity of the Mental Health scale of the EMI.

  17. Development and Validation of the Patient Experience with Treatment and Self-Management (PETS): A Patient-Reported Measure of Treatment Burden

    PubMed Central

    Eton, David T.; Yost, Kathleen J.; Lai, Jin-shei; Ridgeway, Jennifer L.; Egginton, Jason S.; Rosedahl, Jordan K.; Linzer, Mark; Boehm, Deborah H.; Thakur, Azra; Poplau, Sara; Odell, Laura; Montori, Victor M.; May, Carl R.; Anderson, Roger T.

    2017-01-01

    Purpose The purpose of this study was to develop and validate a new comprehensive patient-reported measure of treatment burden – the Patient Experience with Treatment and Self-Management (PETS). Methods A conceptual framework was used to derive the PETS with items reviewed and cognitively tested with patients. A survey battery, including a pilot version of the PETS, was mailed to 838 multi-morbid patients from two healthcare institutions for validation. Results A total of 332 multi-morbid patients returned completed surveys. Diagnostics supported deletion and consolidation of some items and domains. Confirmatory factor analysis supported a domain model for scaling comprised of 9 factors: medical information, medications, medical appointments, monitoring health, interpersonal challenges, medical/healthcare expenses, difficulty with healthcare services, role/social activity limitations, and physical/mental exhaustion. Scales showed good internal consistency (alpha range: 0.79 – 0.95). Higher PETS scores, indicative of greater treatment burden, were correlated with more distress, less satisfaction with medications, lower self-efficacy, worse physical and mental health, and lower convenience of healthcare (Ps<.001). Patients with lower health literacy, less adherence to medications, and more financial difficulties reported higher PETS scores (Ps<.01). Conclusion A comprehensive patient-reported measure of treatment burden can help to better characterize the impact of treatment and self-management burden on patient well-being and guide care toward minimally disruptive medicine. PMID:27566732

  18. Development and validation of the Patient Experience with Treatment and Self-management (PETS): a patient-reported measure of treatment burden.

    PubMed

    Eton, David T; Yost, Kathleen J; Lai, Jin-Shei; Ridgeway, Jennifer L; Egginton, Jason S; Rosedahl, Jordan K; Linzer, Mark; Boehm, Deborah H; Thakur, Azra; Poplau, Sara; Odell, Laura; Montori, Victor M; May, Carl R; Anderson, Roger T

    2017-02-01

    The purpose of this study was to develop and validate a new comprehensive patient-reported measure of treatment burden-the Patient Experience with Treatment and Self-management (PETS). A conceptual framework was used to derive the PETS with items reviewed and cognitively tested with patients. A survey battery, including a pilot version of the PETS, was mailed to 838 multi-morbid patients from two healthcare institutions for validation. A total of 332 multi-morbid patients returned completed surveys. Diagnostics supported deletion and consolidation of some items and domains. Confirmatory factor analysis supported a domain model for scaling comprised of 9 factors: medical information, medications, medical appointments, monitoring health, interpersonal challenges, medical/healthcare expenses, difficulty with healthcare services, role/social activity limitations, and physical/mental exhaustion. Scales showed good internal consistency (α range 0.79-0.95). Higher PETS scores, indicative of greater treatment burden, were correlated with more distress, less satisfaction with medications, lower self-efficacy, worse physical and mental health, and lower convenience of healthcare (Ps < 0.001). Patients with lower health literacy, less adherence to medications, and more financial difficulties reported higher PETS scores (Ps < 0.01). A comprehensive patient-reported measure of treatment burden can help to better characterize the impact of treatment and self-management burden on patient well-being and guide care toward minimally disruptive medicine.

  19. Validation of single-fluid and two-fluid magnetohydrodynamic models of the helicity injected torus spheromak experiment with the NIMROD code

    NASA Astrophysics Data System (ADS)

    Akcay, Cihan; Kim, Charlson C.; Victor, Brian S.; Jarboe, Thomas R.

    2013-08-01

    We present a comparison study of 3-D pressureless resistive MHD (rMHD) and 3-D presureless two-fluid MHD models of the Helicity Injected Torus with Steady Inductive helicity injection (HIT-SI). HIT-SI is a current drive experiment that uses two geometrically asymmetric helicity injectors to generate and sustain toroidal plasmas. The comparable size of the collisionless ion skin depth di to the resistive skin depth predicates the importance of the Hall term for HIT-SI. The simulations are run with NIMROD, an initial-value, 3-D extended MHD code. The modeled plasma density and temperature are assumed uniform and constant. The helicity injectors are modeled as oscillating normal magnetic and parallel electric field boundary conditions. The simulations use parameters that closely match those of the experiment. The simulation output is compared to the formation time, plasma current, and internal and surface magnetic fields. Results of the study indicate 2fl-MHD shows quantitative agreement with the experiment while rMHD only captures the qualitative features. The validity of each model is assessed based on how accurately it reproduces the global quantities as well as the temporal and spatial dependence of the measured magnetic fields. 2fl-MHD produces the current amplification Itor/Iinj and formation time τf demonstrated by HIT-SI with similar internal magnetic fields. rMHD underestimates Itor/Iinj and exhibits much a longer τf. Biorthogonal decomposition (BD), a powerful mathematical tool for reducing large data sets, is employed to quantify how well the simulations reproduce the measured surface magnetic fields without resorting to a probe-by-probe comparison. BD shows that 2fl-MHD captures the dominant surface magnetic structures and the temporal behavior of these features better than rMHD.

  20. Validation of single-fluid and two-fluid magnetohydrodynamic models of the helicity injected torus spheromak experiment with the NIMROD code

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Akcay, Cihan; Victor, Brian S.; Jarboe, Thomas R.

    We present a comparison study of 3-D pressureless resistive MHD (rMHD) and 3-D presureless two-fluid MHD models of the Helicity Injected Torus with Steady Inductive helicity injection (HIT-SI). HIT-SI is a current drive experiment that uses two geometrically asymmetric helicity injectors to generate and sustain toroidal plasmas. The comparable size of the collisionless ion skin depth d{sub i} to the resistive skin depth predicates the importance of the Hall term for HIT-SI. The simulations are run with NIMROD, an initial-value, 3-D extended MHD code. The modeled plasma density and temperature are assumed uniform and constant. The helicity injectors are modeledmore » as oscillating normal magnetic and parallel electric field boundary conditions. The simulations use parameters that closely match those of the experiment. The simulation output is compared to the formation time, plasma current, and internal and surface magnetic fields. Results of the study indicate 2fl-MHD shows quantitative agreement with the experiment while rMHD only captures the qualitative features. The validity of each model is assessed based on how accurately it reproduces the global quantities as well as the temporal and spatial dependence of the measured magnetic fields. 2fl-MHD produces the current amplification (I{sub tor}/I{sub inj}) and formation time τ{sub f} demonstrated by HIT-SI with similar internal magnetic fields. rMHD underestimates (I{sub tor}/I{sub inj}) and exhibits much a longer τ{sub f}. Biorthogonal decomposition (BD), a powerful mathematical tool for reducing large data sets, is employed to quantify how well the simulations reproduce the measured surface magnetic fields without resorting to a probe-by-probe comparison. BD shows that 2fl-MHD captures the dominant surface magnetic structures and the temporal behavior of these features better than rMHD.« less

  1. Good reliability and validity for a new utility instrument measuring the birth experience, the Labor and Delivery Index.

    PubMed

    Gärtner, Fania R; de Miranda, Esteriek; Rijnders, Marlies E; Freeman, Liv M; Middeldorp, Johanna M; Bloemenkamp, Kitty W M; Stiggelbout, Anne M; van den Akker-van Marle, M Elske

    2015-10-01

    To validate the Labor and Delivery Index (LADY-X), a new delivery-specific utility measure. In a test-retest design, women were surveyed online, 6 to 8 weeks postpartum and again 1 to 2 weeks later. For reliability testing, we assessed the standard error of measurement (S.E.M.) and the intraclass correlation coefficient (ICC). For construct validity, we tested hypotheses on the association with comparison instruments (Mackey Childbirth Satisfaction Rating Scale and Wijma Delivery Experience Questionnaire), both on domain and total score levels. We assessed known-group differences using eight obstetrical indicators: method and place of birth, induction, transfer, control over pain medication, complications concerning mother and child, and experienced control. The questionnaire was completed by 308 women, 257 (83%) completed the retest. The distribution of LADY-X scores was skewed. The reliability was good, as the ICC exceeded 0.80 and the S.E.M. was 0.76. Requirements for good construct validity were fulfilled: all hypotheses for convergent and divergent validity were confirmed, and six of eight hypotheses for known-group differences were confirmed as all differences were statistically significant (P-values: <0.001-0.023), but for two tests, difference scores did not exceed the S.E.M. The LADY-X demonstrates good reliability and construct validity. Despite its skewed distribution, the LADY-X can discriminate between groups. With the preference weights available, the LADY-X might fulfill the need for a utility measure for cost-effectiveness studies for perinatal care interventions. Copyright © 2015 Elsevier Inc. All rights reserved.

  2. Development and Score Validation of a Chemistry Laboratory Anxiety Instrument (CLAI) for College Chemistry Students.

    ERIC Educational Resources Information Center

    Bowen, Craig W.

    1999-01-01

    Reports the development and score validation of an instrument for measuring anxieties students experience in college chemistry laboratories. Factor analysis of scores from 361 college students shows that the developed Chemistry Laboratory Anxiety Instrument measures five constructs. Results from a second sample of 598 students show that scores on…

  3. Examining the Internal Validity and Statistical Precision of the Comparative Interrupted Time Series Design by Comparison with a Randomized Experiment

    ERIC Educational Resources Information Center

    St.Clair, Travis; Cook, Thomas D.; Hallberg, Kelly

    2014-01-01

    Although evaluators often use an interrupted time series (ITS) design to test hypotheses about program effects, there are few empirical tests of the design's validity. We take a randomized experiment on an educational topic and compare its effects to those from a comparative ITS (CITS) design that uses the same treatment group as the experiment…

  4. EOS Terra Validation Program

    NASA Technical Reports Server (NTRS)

    Starr, David

    2000-01-01

    The EOS Terra mission will be launched in July 1999. This mission has great relevance to the atmospheric radiation community and global change issues. Terra instruments include Advanced Spaceborne Thermal Emission and Reflection Radiometer (ASTER), Clouds and Earth's Radiant Energy System (CERES), Multi-Angle Imaging Spectroradiometer (MISR), Moderate Resolution Imaging Spectroradiometer (MODIS) and Measurements of Pollution in the Troposphere (MOPITT). In addition to the fundamental radiance data sets, numerous global science data products will be generated, including various Earth radiation budget, cloud and aerosol parameters, as well as land surface, terrestrial ecology, ocean color, and atmospheric chemistry parameters. Significant investments have been made in on-board calibration to ensure the quality of the radiance observations. A key component of the Terra mission is the validation of the science data products. This is essential for a mission focused on global change issues and the underlying processes. The Terra algorithms have been subject to extensive pre-launch testing with field data whenever possible. Intensive efforts will be made to validate the Terra data products after launch. These include validation of instrument calibration (vicarious calibration) experiments, instrument and cross-platform comparisons, routine collection of high quality correlative data from ground-based networks, such as AERONET, and intensive sites, such as the SGP ARM site, as well as a variety field experiments, cruises, etc. Airborne simulator instruments have been developed for the field experiment and underflight activities including the MODIS Airborne Simulator (MAS) AirMISR, MASTER (MODIS-ASTER), and MOPITT-A. All are integrated on the NASA ER-2 though low altitude platforms are more typically used for MASTER. MATR is an additional sensor used for MOPITT algorithm development and validation. The intensive validation activities planned for the first year of the Terra

  5. Physics Reality Show

    NASA Astrophysics Data System (ADS)

    Erukhimova, Tatiana

    The attention span of K-12 students is very short; they are used to digesting information in short snippets through social media and TV. To get the students interested in physics, we created the Physics Reality Show: a series of staged short videos with duration no longer than a few minutes. Each video explains and illustrates one physics concept or law through a fast-paced sequence of physics demonstrations and experiments. The cast consists entirely of physics undergraduate students with artistic abilities and substantial experience in showing physics demonstrations at current outreach events run by the department: Physics Shows and Physics & Engineering Festival. Undergraduate students are of almost the same age as their high-school audience. They are in the best position to connect with kids and convey their fascination with physics. The PI and other faculty members who are involved in the outreach advise and coach the cast. They help students in staging the episodes and choosing the most exciting and relevant demonstrations. Supported by the APS mini-outreach Grant.

  6. Analytical procedure validation and the quality by design paradigm.

    PubMed

    Rozet, Eric; Lebrun, Pierre; Michiels, Jean-François; Sondag, Perceval; Scherder, Tara; Boulanger, Bruno

    2015-01-01

    Since the adoption of the ICH Q8 document concerning the development of pharmaceutical processes following a quality by design (QbD) approach, there have been many discussions on the opportunity for analytical procedure developments to follow a similar approach. While development and optimization of analytical procedure following QbD principles have been largely discussed and described, the place of analytical procedure validation in this framework has not been clarified. This article aims at showing that analytical procedure validation is fully integrated into the QbD paradigm and is an essential step in developing analytical procedures that are effectively fit for purpose. Adequate statistical methodologies have also their role to play: such as design of experiments, statistical modeling, and probabilistic statements. The outcome of analytical procedure validation is also an analytical procedure design space, and from it, control strategy can be set.

  7. Validating presupposed versus focused text information.

    PubMed

    Singer, Murray; Solar, Kevin G; Spear, Jackie

    2017-04-01

    There is extensive evidence that readers continually validate discourse accuracy and congruence, but that they may also overlook conspicuous text contradictions. Validation may be thwarted when the inaccurate ideas are embedded sentence presuppositions. In four experiments, we examined readers' validation of presupposed ("given") versus new text information. Throughout, a critical concept, such as a truck versus a bus, was introduced early in a narrative. Later, a character stated or thought something about the truck, which therefore matched or mismatched its antecedent. Furthermore, truck was presented as either given or new information. Mismatch target reading times uniformly exceeded the matching ones by similar magnitudes for given and new concepts. We obtained this outcome using different grammatical constructions and with different antecedent-target distances. In Experiment 4, we examined only given critical ideas, but varied both their matching and the main verb's factivity (e.g., factive know vs. nonfactive think). The Match × Factivity interaction closely resembled that previously observed for new target information (Singer, 2006). Thus, readers can successfully validate given target information. Although contemporary theories tend to emphasize either deficient or successful validation, both types of theory can accommodate the discourse and reader variables that may regulate validation.

  8. Further Validation of the Coach Identity Prominence Scale

    ERIC Educational Resources Information Center

    Pope, J. Paige; Hall, Craig R.

    2014-01-01

    This study was designed to examine select psychometric properties of the Coach Identity Prominence Scale (CIPS), including the reliability, factorial validity, convergent validity, discriminant validity, and predictive validity. Coaches (N = 338) who averaged 37 (SD = 12.27) years of age, had a mean of 13 (SD = 9.90) years of coaching experience,…

  9. Verification and Validation of Requirements on the CEV Parachute Assembly System Using Design of Experiments

    NASA Technical Reports Server (NTRS)

    Schulte, Peter Z.; Moore, James W.

    2011-01-01

    The Crew Exploration Vehicle Parachute Assembly System (CPAS) project conducts computer simulations to verify that flight performance requirements on parachute loads and terminal rate of descent are met. Design of Experiments (DoE) provides a systematic method for variation of simulation input parameters. When implemented and interpreted correctly, a DoE study of parachute simulation tools indicates values and combinations of parameters that may cause requirement limits to be violated. This paper describes one implementation of DoE that is currently being developed by CPAS, explains how DoE results can be interpreted, and presents the results of several preliminary studies. The potential uses of DoE to validate parachute simulation models and verify requirements are also explored.

  10. A method to determine the mammographic regions that show early changes due to the development of breast cancer

    NASA Astrophysics Data System (ADS)

    Karemore, Gopal; Nielsen, Mads; Karssemeijer, Nico; Brandt, Sami S.

    2014-11-01

    It is well understood nowadays that changes in the mammographic parenchymal pattern are an indicator of a risk of breast cancer and we have developed a statistical method that estimates the mammogram regions where the parenchymal changes, due to breast cancer, occur. This region of interest is computed from a score map by utilising the anatomical breast coordinate system developed in our previous work. The method also makes an automatic scale selection to avoid overfitting while the region estimates are computed by a nested cross-validation scheme. In this way, it is possible to recover those mammogram regions that show a significant difference in classification scores between the cancer and the control group. Our experiments suggested that the most significant mammogram region is the region behind the nipple and that can be justified by previous findings from other research groups. This result was conducted on the basis of the cross-validation experiments on independent training, validation and testing sets from the case-control study of 490 women, of which 245 women were diagnosed with breast cancer within a period of 2-4 years after the baseline mammograms. We additionally generalised the estimated region to another, mini-MIAS study and showed that the transferred region estimate gives at least a similar classification result when compared to the case where the whole breast region is used. In all, by following our method, one most likely improves both preclinical and follow-up breast cancer screening, but a larger study population will be required to test this hypothesis.

  11. The Self-Description Inventory+, Part 1: Factor Structure and Convergent Validity Analyses

    DTIC Science & Technology

    2013-07-01

    measures 12 scales of personality. The current report examines the possibility of replacing the EQ with a Five Factor Model ( FFM ) measure of...Checklist. Our results show that the SDI + has scales that are intercorrelated in a manner consistent with the FFM (Experiment 1), a factor structure...met the criteria showing it to be an FFM instrument, we will conduct concurrent validity research to determine if the SDI+ has greater predictive

  12. Validation Study of Unnotched Charpy and Taylor-Anvil Impact Experiments using Kayenta

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Kamojjala, Krishna; Lacy, Jeffrey; Chu, Henry S.

    2015-03-01

    Validation of a single computational model with multiple available strain-to-failure fracture theories is presented through experimental tests and numerical simulations of the standardized unnotched Charpy and Taylor-anvil impact tests, both run using the same material model (Kayenta). Unnotched Charpy tests are performed on rolled homogeneous armor steel. The fracture patterns using Kayenta’s various failure options that include aleatory uncertainty and scale effects are compared against the experiments. Other quantities of interest include the average value of the absorbed energy and bend angle of the specimen. Taylor-anvil impact tests are performed on Ti6Al4V titanium alloy. The impact speeds of the specimenmore » are 321 m/s and 393 m/s. The goal of the numerical work is to reproduce the damage patterns observed in the laboratory. For the numerical study, the Johnson-Cook failure model is used as the ductile fracture criterion, and aleatory uncertainty is applied to rate-dependence parameters to explore its effect on the fracture patterns.« less

  13. Development and validation of a multifactor mindfulness scale in youth: The Comprehensive Inventory of Mindfulness Experiences-Adolescents (CHIME-A).

    PubMed

    Johnson, Catherine; Burke, Christine; Brinkman, Sally; Wade, Tracey

    2017-03-01

    Mindfulness-based interventions show consistent benefits in adults for a range of pathologies, but exploration of these approaches in youth is an emergent field, with limited measures of mindfulness for this population. This study aimed to investigate whether multifactor scales of mindfulness can be used in adolescents. A series of studies are presented assessing the performance of a recently developed adult measure, the Comprehensive Inventory of Mindfulness Experiences (CHIME) in 4 early adolescent samples. Study 1 was an investigation of how well the full adult measure (37 items) was understood by youth (N = 292). Study 2 piloted a revision of items in child friendly language with a small group (N = 48). The refined questionnaire for adolescents (CHIME-A) was then tested in Study 3 in a larger sample (N = 461) and subjected to exploratory factor analysis and a range of external validity measures. Study 4 was a confirmatory factor analysis in a new sample (N = 498) with additional external validity measures. Study 5 tested temporal stability (N = 120). Results supported an 8-factor 25-item measure of mindfulness in adolescents, with excellent model fit indices and sound internal consistency for the 8 subscales. Although the CFA supported an overarching factor, internal reliability of a combined total score was poor. The development of a multifactor measure represents a first step toward testing developmental models of mindfulness in young people. This in turn will aid construction of evidence based interventions that are not simply downward derivations of adult mindfulness programs. (PsycINFO Database Record (c) 2017 APA, all rights reserved).

  14. Development and Validation of the Caring Loneliness Scale.

    PubMed

    Karhe, Liisa; Kaunonen, Marja; Koivisto, Anna-Maija

    2016-12-01

    The Caring Loneliness Scale (CARLOS) includes 5 categories derived from earlier qualitative research. This article assesses the reliability and construct validity of a scale designed to measure patient experiences of loneliness in a professional caring relationship. Statistical analysis with 4 different sample sizes included Cronbach's alpha and exploratory factor analysis with principal axis factoring extraction. The sample size of 250 gave the most useful and comprehensible structure, but all 4 samples yielded underlying content of loneliness experiences. The initial 5 categories were reduced to 4 factors with 24 items and Cronbach's alpha ranging from .77 to .90. The findings support the reliability and validity of CARLOS for the assessment of Finnish breast cancer and heart surgery patients' experiences but as all instruments, further validation is needed.

  15. The Space Technology-7 Disturbance Reduction System Precision Control Flight Validation Experiment Control System Design

    NASA Technical Reports Server (NTRS)

    O'Donnell, James R.; Hsu, Oscar C.; Maghami, Peirman G.; Markley, F. Landis

    2006-01-01

    As originally proposed, the Space Technology-7 Disturbance Reduction System (DRS) project, managed out of the Jet Propulsion Laboratory, was designed to validate technologies required for future missions such as the Laser Interferometer Space Antenna (LISA). The two technologies to be demonstrated by DRS were Gravitational Reference Sensors (GRSs) and Colloidal MicroNewton Thrusters (CMNTs). Control algorithms being designed by the Dynamic Control System (DCS) team at the Goddard Space Flight Center would control the spacecraft so that it flew about a freely-floating GRS test mass, keeping it centered within its housing. For programmatic reasons, the GRSs were descoped from DRS. The primary goals of the new mission are to validate the performance of the CMNTs and to demonstrate precise spacecraft position control. DRS will fly as a part of the European Space Agency (ESA) LISA Pathfinder (LPF) spacecraft along with a similar ESA experiment, the LISA Technology Package (LTP). With no GRS, the DCS attitude and drag-free control systems make use of the sensor being developed by ESA as a part of the LTP. The control system is designed to maintain the spacecraft s position with respect to the test mass, to within 10 nm/the square root of Hz over the DRS science frequency band of 1 to 30 mHz.

  16. Construct validation of a novel hybrid surgical simulator.

    PubMed

    Broe, D; Ridgway, P F; Johnson, S; Tierney, S; Conlon, K C

    2006-06-01

    Simulated minimal access surgery has improved recently as both a learning and assessment tool. The construct validation of a novel simulator, ProMis, is described for use by residents in training. ProMis is a surgical simulator that can design tasks in both virtual and actual reality. A pilot group of surgical residents ranging from novice to expert completed three standardized tasks: orientation, dissection, and basic suturing. The tasks were tested for construct validity. Two experienced surgeons examined the recorded tasks in a blinded fashion using an objective structured assessment of technical skills format (OSATS: task-specific checklist and global rating score) as well as metrics delivered by the simulator. The findings showed excellent interrater reliability (Cronbach's alpha of 0.88 for the checklist and 0.93 for the global rating). The median scores in the experience groups were statistically different in both the global rating and the task-specific checklists (p < 0.05). The scores for the orientation task alone did not reach significance (p = 0.1), suggesting that modification is required before ProMis could be used in isolation as an assessment tool. The three simulated tasks in combination are construct valid for differentiating experience levels among surgeons in training. This hybrid simulator has potential added benefits of marrying the virtual with actual, and of combining simple box traits and advanced virtual reality simulation.

  17. [Reliability and validity of the Chinese version on Alcohol Use Disorders Identification Test].

    PubMed

    Zhang, C; Yang, G P; Li, Z; Li, X N; Li, Y; Hu, J; Zhang, F Y; Zhang, X J

    2017-08-10

    Objective: To assess the reliability and validity of the Chinese version on Alcohol Use Disorders Identification Test (AUDIT) among medical students in China and to provide correct way of application on the recommended scales. Methods: An E-questionnaire was developed and sent to medical students in five different colleges. Students were all active volunteers to accept the testings. Cronbach's α and split-half reliability were calculated to evaluate the reliability of AUDIT while content, contract, discriminant and convergent validity were performed to measure the validity of the scales. Results: The overall Cronbach's α of AUDIT was 0.782 and the split-half reliability was 0.711. Data showed that the domain Cronbach's α and split-half reliability were 0.796 and 0.794 for hazardous alcohol use, 0.561 and 0.623 for dependence symptoms, and 0.647 and 0.640 for harmful alcohol use. Results also showed that the content validity index on the levels of items I-CVI) were from 0.83 to 1.00, the content validity index of scale level (S-CVI/UA) was 0.90, content validity index of average scale level (S-CVI/Ave) was 0.99 and the content validity ratios (CVR) were from 0.80 to 1.00. The simplified version of AUDIT supported a presupposed three-factor structure which could explain 61.175% of the total variance revealed through exploratory factor analysis. AUDIT semed to have good convergent and discriminant validity, with the success rate of calibration experiment as 100%. Conclusion: AUDIT showed good reliability and validity among medical students in China thus worth for promotion on its use.

  18. The Role of Structural Models in the Solar Sail Flight Validation Process

    NASA Technical Reports Server (NTRS)

    Johnston, John D.

    2004-01-01

    NASA is currently soliciting proposals via the New Millennium Program ST-9 opportunity for a potential Solar Sail Flight Validation (SSFV) experiment to develop and operate in space a deployable solar sail that can be steered and provides measurable acceleration. The approach planned for this experiment is to test and validate models and processes for solar sail design, fabrication, deployment, and flight. These models and processes would then be used to design, fabricate, and operate scaleable solar sails for future space science missions. There are six validation objectives planned for the ST9 SSFV experiment: 1) Validate solar sail design tools and fabrication methods; 2) Validate controlled deployment; 3) Validate in space structural characteristics (focus of poster); 4) Validate solar sail attitude control; 5) Validate solar sail thrust performance; 6) Characterize the sail's electromagnetic interaction with the space environment. This poster presents a top-level assessment of the role of structural models in the validation process for in-space structural characteristics.

  19. Validation of multiprocessor systems

    NASA Technical Reports Server (NTRS)

    Siewiorek, D. P.; Segall, Z.; Kong, T.

    1982-01-01

    Experiments that can be used to validate fault free performance of multiprocessor systems in aerospace systems integrating flight controls and avionics are discussed. Engineering prototypes for two fault tolerant multiprocessors are tested.

  20. MotiveValidator: interactive web-based validation of ligand and residue structure in biomolecular complexes.

    PubMed

    Vařeková, Radka Svobodová; Jaiswal, Deepti; Sehnal, David; Ionescu, Crina-Maria; Geidl, Stanislav; Pravda, Lukáš; Horský, Vladimír; Wimmerová, Michaela; Koča, Jaroslav

    2014-07-01

    Structure validation has become a major issue in the structural biology community, and an essential step is checking the ligand structure. This paper introduces MotiveValidator, a web-based application for the validation of ligands and residues in PDB or PDBx/mmCIF format files provided by the user. Specifically, MotiveValidator is able to evaluate in a straightforward manner whether the ligand or residue being studied has a correct annotation (3-letter code), i.e. if it has the same topology and stereochemistry as the model ligand or residue with this annotation. If not, MotiveValidator explicitly describes the differences. MotiveValidator offers a user-friendly, interactive and platform-independent environment for validating structures obtained by any type of experiment. The results of the validation are presented in both tabular and graphical form, facilitating their interpretation. MotiveValidator can process thousands of ligands or residues in a single validation run that takes no more than a few minutes. MotiveValidator can be used for testing single structures, or the analysis of large sets of ligands or fragments prepared for binding site analysis, docking or virtual screening. MotiveValidator is freely available via the Internet at http://ncbr.muni.cz/MotiveValidator. © The Author(s) 2014. Published by Oxford University Press on behalf of Nucleic Acids Research.

  1. AMSR Validation Program

    NASA Astrophysics Data System (ADS)

    Lobl, E. S.

    2003-12-01

    AMSR and AMSR-E are passive microwave radiometers built by NASDA in Japan. AMSR flies on ADEOS II, launched December 14 2001, and AMSR-E flies on NASA's Aqua satellite, launched May 4 2001. The Science teams in both countries have developed algorithms to retrieve different atmospheric parameters from the data obtained by these radiometers. The US Science team has developed a Validation plan that involved several campaigns. In fact most of these campaign have taken place this year: 2003, nicknamed the "Golden Year" for AMSR Validation. The first campaign started in January 2003 with the Extra-tropical precipitation campaign, followed by IOP3 for Cold Lands Processes Experiment (CLPX) in Colorado. After the change out of some of the instruments, the Validation program continued with the Arctic Sea Ice campaign based in Alaska, and followed by CLPX IOP 4, back in Colorado. Soil Moisture EXperiment 03 (SMEX03) started in late June in Alabama and Georgia, and then completed in Oklahoma mid-July. The last campaign in this series is AMSR Antarctic Sea Ice (AASI)/SMEX in Brazil. The major goals of each campaign, and very preliminary data will be shown. Most of these campaigns were in collaboration with the Japanese AMSR scientists.

  2. Analysis of in situ resources for the Soil Moisture Active Passive Validation Experiments in 2015 and 2016

    NASA Astrophysics Data System (ADS)

    Cosh, M. H.; Jackson, T. J.; Colliander, A.; Bindlish, R.; McKee, L.; Goodrich, D. C.; Prueger, J. H.; Hornbuckle, B. K.; Coopersmith, E. J.; Holifield Collins, C.; Smith, J.

    2016-12-01

    With the launch of the Soil Moisture Active Passive Mission (SMAP) in 2015, a new era of soil moisture monitoring was begun. Soil moisture is available on a near daily basis at a 36 km resolution for the globe. But this dataset is only as valuable if its products are accurate and reliable. Therefore, in order to demonstrate the accuracy of the soil moisture product, NASA enacted an extensive calibration and validation program with many in situ soil moisture networks contributing data across a variety of landscape regimes. However, not all questions can be answered by these networks. As a result, two intensive field experiments were executed to provide more detailed reference points for calibration and validation. Multi-week field campaigns were conducted in Arizona and Iowa at the USDA Agricultural Research Service Walnut Gulch and South Fork Experimental Watersheds, respectively. Aircraft observations were made to provide a high resolution data product. Soil moisture, soil roughness and vegetation data were collected at high resolution to provide a downscaled dataset to compare against aircraft and satellite estimates.

  3. Multiscale GPS tomography during COPS: validation and applications

    NASA Astrophysics Data System (ADS)

    Champollion, Cédric; Flamant, Cyrille; Masson, Frédéric; Gégout, Pascal; Boniface, Karen; Richard, Evelyne

    2010-05-01

    Accurate 3D description of the water vapour field is of interest for process studies such as convection initiation. None of the current techniques (LIDAR, satellite, radio soundings, GPS) can provide an all weather continuous 3D field of moisture. The combination of GPS tomography with radio-soundings (and/or LIDAR) has been used for such process studies using both advantages of vertically resolved soundings and high temporal density of GPS measurements. GPS tomography has been used at short scale (10 km horizontal resolution but in a 50 km² area) for process studies such as the ESCOMPTE experiment (Bastin et al., 2005) and at larger scale (50 km horizontal resolution) during IHOP_2002. But no extensive statistical validation has been done so far. The overarching goal of the COPS field experiment is to advance the quality of forecasts of orographically induced convective precipitation by four-dimensional observations and modeling of its life cycle for identifying the physical and chemical processes responsible for deficiencies in QPF over low-mountain regions. During the COPS field experiment, a GPS network of about 100 GPS stations has been continuously operating during three months in an area of 500 km² in the East of France (Vosges Mountains) and West of Germany (Black Forest). If the mean spacing between the GPS is about 50 km, an East-West GPS profile with a density of about 10 km is dedicated to high resolution tomography. One major goal of the GPS COPS experiment is to validate the GPS tomography with different spatial resolutions. Validation is based on additional radio-soundings and airborne / ground-based LIDAR measurement. The number and the high quality of vertically resolved water vapor observations give an unique data set for GPS tomography validation. Numerous tests have been done on real data to show the type water vapor structures that can be imaging by GPS tomography depending of the assimilation of additional data (radio soundings), the

  4. Development and preliminary validation of an interactive remote physical therapy system.

    PubMed

    Mishra, Anup K; Skubic, Marjorie; Abbott, Carmen

    2015-01-01

    In this paper, we present an interactive physical therapy system (IPTS) for remote quantitative assessment of clients in the home. The system consists of two different interactive interfaces connected through a network, for a real-time low latency video conference using audio, video, skeletal, and depth data streams from a Microsoft Kinect. To test the potential of IPTS, experiments were conducted with 5 independent living senior subjects in Kansas City, MO. Also, experiments were conducted in the lab to validate the real-time biomechanical measures calculated using the skeletal data from the Microsoft Xbox 360 Kinect and Microsoft Xbox One Kinect, with ground truth data from a Vicon motion capture system. Good agreements were found in the validation tests. The results show potential capabilities of the IPTS system to provide remote physical therapy to clients, especially older adults, who may find it difficult to visit the clinic.

  5. High spatial validity is not sufficient to elicit voluntary shifts of attention.

    PubMed

    Pauszek, Joseph R; Gibson, Bradley S

    2016-10-01

    Previous research suggests that the use of valid symbolic cues is sufficient to elicit voluntary shifts of attention. The present study interpreted this previous research within a broader theoretical context which contends that observers will voluntarily use symbolic cues to orient their attention in space when the temporal costs of using the cues are perceived to be less than the temporal costs of searching without the aid of the cues. In this view, previous research has not addressed the sufficiency of valid symbolic cues, because the temporal cost of using the cues is usually incurred before the target display appears. To address this concern, 70%-valid spatial word cues were presented simultaneously with a search display. In addition, other research suggests that opposing cue-dependent and cue-independent spatial biases may operate in these studies and alter standard measures of orienting. After identifying and controlling these opposing spatial biases, the results of two experiments showed that the word cues did not elicit voluntary shifts of attention when the search task was relatively easy but did when the search task was relatively difficult. Moreover, the findings also showed that voluntary use of the word cues changed over the course of the experiment when the task was difficult, presumably because the temporal cost of searching without the cue lessened as the task got easier with practice. Altogether, the present findings suggested that the factors underlying voluntary control are multifaceted and contextual, and that spatial validity alone is not sufficient to elicit voluntary shifts of attention.

  6. Status Update on the GPM Ground Validation Iowa Flood Studies (IFloodS) Field Experiment

    NASA Astrophysics Data System (ADS)

    Petersen, Walt; Krajewski, Witold

    2013-04-01

    The overarching objective of integrated hydrologic ground validation activities supporting the Global Precipitation Measurement Mission (GPM) is to provide better understanding of the strengths and limitations of the satellite products, in the context of hydrologic applications. To this end, the GPM Ground Validation (GV) program is conducting the first of several hydrology-oriented field efforts: the Iowa Flood Studies (IFloodS) experiment. IFloodS will be conducted in the central to northeastern part of Iowa in Midwestern United States during the months of April-June, 2013. Specific science objectives and related goals for the IFloodS experiment can be summarized as follows: 1. Quantify the physical characteristics and space/time variability of rain (rates, DSD, process/"regime") and map to satellite rainfall retrieval uncertainty. 2. Assess satellite rainfall retrieval uncertainties at instantaneous to daily time scales and evaluate propagation/impact of uncertainty in flood-prediction. 3. Assess hydrologic predictive skill as a function of space/time scales, basin morphology, and land use/cover. 4. Discern the relative roles of rainfall quantities such as rate and accumulation as compared to other factors (e.g. transport of water in the drainage network) in flood genesis. 5. Refine approaches to "integrated hydrologic GV" concept based on IFloodS experiences and apply to future GPM Integrated GV field efforts. These objectives will be achieved via the deployment of the NASA NPOL S-band and D3R Ka/Ku-band dual-polarimetric radars, University of Iowa X-band dual-polarimetric radars, a large network of paired rain gauge platforms with attendant soil moisture and temperature probes, a large network of both 2D Video and Parsivel disdrometers, and USDA-ARS gauge and soil-moisture measurements (in collaboration with the NASA SMAP mission). The aforementioned measurements will be used to complement existing operational WSR-88D S-band polarimetric radar measurements

  7. Identification and validation of seven new loci showing differential DNA methylation related to serum lipid profile: an epigenome-wide approach. The REGICOR study.

    PubMed

    Sayols-Baixeras, S; Subirana, I; Lluis-Ganella, C; Civeira, F; Roquer, J; Do, A N; Absher, D; Cenarro, A; Muñoz, D; Soriano-Tárraga, C; Jiménez-Conde, J; Ordovas, J M; Senti, M; Aslibekyan, S; Marrugat, J; Arnett, D K; Elosua, R

    2016-10-15

    Lipid traits (total, low-density and high-density lipoprotein cholesterol, and triglycerides) are risk factors for cardiovascular disease. DNA methylation is not only an inherited but also modifiable epigenetic mark that has been related to cardiovascular risk factors. Our aim was to identify loci showing differential DNA methylation related to serum lipid levels. Blood DNA methylation was assessed using the Illumina Human Methylation 450 BeadChip. A two-stage epigenome-wide association study was performed, with a discovery sample in the REGICOR study (n = 645) and validation in the Framingham Offspring Study (n = 2,542). Fourteen CpG sites located in nine genes (SREBF1, SREBF2, PHOSPHO1, SYNGAP1, ABCG1, CPT1A, MYLIP, TXNIP and SLC7A11) and 2 intergenic regions showed differential methylation in association with lipid traits. Six of these genes and 1 intergenic region were new discoveries showing differential methylation related to total cholesterol (SREBF2), HDL-cholesterol (PHOSPHO1, SYNGAP1 and an intergenic region in chromosome 2) and triglycerides (MYLIP, TXNIP and SLC7A11). These CpGs explained 0.7%, 9.5% and 18.9% of the variability of total cholesterol, HDL cholesterol and triglycerides in the Framingham Offspring Study, respectively. The expression of the genes SREBF2 and SREBF1 was inversely associated with methylation of their corresponding CpGs (P-value = 0.0042 and 0.0045, respectively) in participants of the GOLDN study (n = 98). In turn, SREBF1 expression was directly associated with HDL cholesterol (P-value = 0.0429). Genetic variants in SREBF1, PHOSPHO1, ABCG1 and CPT1A were also associated with lipid profile. Further research is warranted to functionally validate these new loci and assess the causality of new and established associations between these differentially methylated loci and lipid metabolism.

  8. A 67-Item Stress Resilience item bank showing high content validity was developed in a psychosomatic sample.

    PubMed

    Obbarius, Nina; Fischer, Felix; Obbarius, Alexander; Nolte, Sandra; Liegl, Gregor; Rose, Matthias

    2018-04-10

    To develop the first item bank to measure Stress Resilience (SR) in clinical populations. Qualitative item development resulted in an initial pool of 131 items covering a broad theoretical SR concept. These items were tested in n=521 patients at a psychosomatic outpatient clinic. Exploratory and Confirmatory Factor Analysis (CFA), as well as other state-of-the-art item analyses and IRT were used for item evaluation and calibration of the final item bank. Out of the initial item pool of 131 items, we excluded 64 items (54 factor loading <.5, 4 residual correlations >.3, 2 non-discriminative Item Response Curves, 4 Differential Item Functioning). The final set of 67 items indicated sufficient model fit in CFA and IRT analyses. Additionally, a 10-item short form with high measurement precision (SE≤.32 in a theta range between -1.8 and +1.5) was derived. Both the SR item bank and the SR short form were highly correlated with an existing static legacy tool (Connor-Davidson Resilience Scale). The final SR item bank and 10-item short form showed good psychometric properties. When further validated, they will be ready to be used within a framework of Computer-Adaptive Tests for a comprehensive assessment of the Stress-Construct. Copyright © 2018. Published by Elsevier Inc.

  9. Don't believe everything you hear: Routine validation of audiovisual information in children and adults.

    PubMed

    Piest, Benjamin A; Isberner, Maj-Britt; Richter, Tobias

    2018-04-05

    Previous research has shown that the validation of incoming information during language comprehension is a fast, efficient, and routine process (epistemic monitoring). Previous research on this topic has focused on epistemic monitoring during reading. The present study extended this research by investigating epistemic monitoring of audiovisual information. In a Stroop-like paradigm, participants (Experiment 1: adults; Experiment 2: 10-year-old children) responded to the probe words correct and false by keypress after the presentation of auditory assertions that could be either true or false with respect to concurrently presented pictures. Results provide evidence for routine validation of audiovisual information. Moreover, the results show a stronger and more stable interference effect for children compared with adults.

  10. Absorption in Sport: A Cross-Validation Study

    PubMed Central

    Koehn, Stefan; Stavrou, Nektarios A. M.; Cogley, Jeremy; Morris, Tony; Mosek, Erez; Watt, Anthony P.

    2017-01-01

    Absorption has been identified as readiness for experiences of deep involvement in the task. Conceptually, absorption is a key psychological construct, incorporating experiential, cognitive, and motivational components. Although, no operationalization of the construct has been provided to facilitate research in this area, the purpose of this research was the development and examination of the psychometric properties of a sport-specific measure of absorption that evolved from the use of the modified Tellegen Absorption Scale (MODTAS; Jamieson, 2005) in mainstream psychology. The study aimed to provide evidence of the psychometric properties, reliability, and validity of the Measure of Absorption in Sport Contexts (MASCs). The psychometric examination included a calibration sample from Scotland and a cross-validation sample from Australia using a cross-sectional design. The item pool was developed based on existing items from the modified Tellegen Absorption Scale (Jamieson, 2005). The MODTAS items were reworded and translated into a sport context. The Scottish sample consisted of 292 participants and the Australian sample of 314 participants. Congeneric model testing and confirmatory factor analysis for both samples and multi-group invariance testing across samples was used. In the cross-validation sample the MASC subscales showed acceptable internal consistency and construct reliability (≥0.70). Excellent fit indices were found for the final 18-item, six-factor measure in the cross-validation sample, χ(120)2 = 197.486, p < 0.001; CFI = 0.957; TLI = 0.945; RMSEA = 0.045; SRMR = 0.044. Multi-group invariance testing revealed no differences in item meaning, except for two items. The MASC and the Dispositional Flow Scale-2 showed moderate-to-strong positive correlations in both samples, r = 0.38, p < 0.001 and r = 0.42, p < 0.001, supporting the external validity of the MASC. This article provides initial evidence in support of the psychometric properties

  11. [French validation study of the levels of emotional awareness scale].

    PubMed

    Bydlowski, S; Corcos, M; Paterniti, S; Guilbaud, O; Jeammet, P; Consoli, S M

    2002-01-01

    According to a thesis based on the idea of an influence of cognitions in the structuring of internal reality, emotional awareness, ie the capacity of representing your own emotional experience and that of others, is a cognitive process that goes into maturation. Defining this concept, Lane and Schwartz present a cognitivo-developmental model in five stages of the processes of symbolization, accounting for the differences in levels of emotional awareness observed in individuals. The organization of these cognitive processes would thus be structured in well differentiated stages, in which the development of the emotions would be inseparable from the development of ego and of the relation to others. These authors focus on the capacity of representing in a conscious way the emotional experience and consider that verbal representations used to describe the contents of what is experience constitute a good reflection of the organization structural of the emotional awareness. Therefore, they worked out an instrument of evaluation: the Levels of Emotional Awareness Scale (LEAS), which measures the capacity to describe your own emotional experience and the one you allow to others, in an emotional situation. The system of quotation of this scale is based on the analysis of the verbal contents of the provided answers, in direct reference to the authors' theory of the levels of differentiation and integration of the emotional experience. It is therefore an empirical measurement which is centered specifically on the structural organization of the emotional experience. The various studies of validation of this instrument show that it presents solid metrological properties. This work presents the validation of the French version of Lane and Schwartz's LEAS. Validity and fidelity were studied in a group of 121 healthy subjects. This setting is part of a larger clinical evaluation, also including a collection of socio-demographic and clinical data, and other instruments of self

  12. Validation of the U-238 inelastic scattering neutron cross section through the EXCALIBUR dedicated experiment

    NASA Astrophysics Data System (ADS)

    Leconte, Pierre; Bernard, David

    2017-09-01

    EXCALIBUR is an integral transmission experiment based on the fast neutron source produced by the bare highly enriched fast burst reactor CALIBAN, located in CEA/DAM Valduc (France). Two experimental campaigns have been performed, one using a sphere of diameter 17 cm and one using two cylinders of 17 cm diameter 9 cm height, both made of metallic Uranium 238. A set of 15 different dosimeters with specific threshold energies have been employed to provide information on the neutron flux attenuation as a function of incident energy. Measurements uncertainties are typically in the range of 0.5-3% (1σ). The analysis of these experiments is performed with the TRIPOLI4 continuous energy Monte Carlo code. A calculation benchmark with validated simplifications is defined in order to improve the statistical convergence under 2%. Various 238U evaluations have been tested: JEFF-3.1.1, ENDF/B-VII.1 and the IB36 evaluation from IAEA. A sensitivity analysis is presented to identify the contribution of each reaction cross section to the integral transmission rate. This feedback may be of interest for the international effort on 238U, through the CIELO project.

  13. The Inventory of High-School Students' Recent Life Experiences: A Decontaminated Measure of Adolescents' Hassles.

    ERIC Educational Resources Information Center

    Kohn, Paul M.; Milrose, Jill A.

    1993-01-01

    A decontaminated measure of exposures to hassles for adolescents, the Inventory of High-School Students' Recent Life Experiences (IHSSRLE), was developed and validated with 94 male and 82 female Canadian high school students. The IHSSRLE shows adequate internal consistency reliability and validity against the criterion of subjectively appraised…

  14. Anger Assessment in Clinical and Nonclinical Populations: Further Validation of the State-Trait Anger Expression Inventory-2.

    PubMed

    Lievaart, Marien; Franken, Ingmar H A; Hovens, Johannes E

    2016-03-01

    The most commonly used instrument for measuring anger is the State-Trait Anger Expression Inventory-2 (STAXI-2; Spielberger, 1999). This study further examines the validity of the STAXI-2 and compares anger scores between several clinical and nonclinical samples. Reliability, concurrent, and construct validity were investigated in Dutch undergraduate students (N = 764), a general population sample (N = 1211), and psychiatric outpatients (N = 226). The results support the reliability and validity of the STAXI-2. Concurrent validity was strong, with meaningful correlations between the STAXI-2 scales and anger-related constructs in both clinical and nonclinical samples. Importantly, patients showed higher experience and expression of anger than the general population sample. Additionally, forensic outpatients with addiction problems reported higher Anger Expression-Out than general psychiatric outpatients. Our conclusion is that the STAXI-2 is a suitable instrument to measure both the experience and the expression of anger in both general and clinical populations. © 2016 Wiley Periodicals, Inc.

  15. Validating the performance of correlated fission multiplicity implementation in radiation transport codes with subcritical neutron multiplication benchmark experiments

    DOE PAGES

    Arthur, Jennifer; Bahran, Rian; Hutchinson, Jesson; ...

    2018-06-14

    Historically, radiation transport codes have uncorrelated fission emissions. In reality, the particles emitted by both spontaneous and induced fissions are correlated in time, energy, angle, and multiplicity. This work validates the performance of various current Monte Carlo codes that take into account the underlying correlated physics of fission neutrons, specifically neutron multiplicity distributions. The performance of 4 Monte Carlo codes - MCNP®6.2, MCNP®6.2/FREYA, MCNP®6.2/CGMF, and PoliMi - was assessed using neutron multiplicity benchmark experiments. In addition, MCNP®6.2 simulations were run using JEFF-3.2 and JENDL-4.0, rather than ENDF/B-VII.1, data for 239Pu and 240Pu. The sensitive benchmark parameters that in this workmore » represent the performance of each correlated fission multiplicity Monte Carlo code include the singles rate, the doubles rate, leakage multiplication, and Feynman histograms. Although it is difficult to determine which radiation transport code shows the best overall performance in simulating subcritical neutron multiplication inference benchmark measurements, it is clear that correlations exist between the underlying nuclear data utilized by (or generated by) the various codes, and the correlated neutron observables of interest. This could prove useful in nuclear data validation and evaluation applications, in which a particular moment of the neutron multiplicity distribution is of more interest than the other moments. It is also quite clear that, because transport is handled by MCNP®6.2 in 3 of the 4 codes, with the 4th code (PoliMi) being based on an older version of MCNP®, the differences in correlated neutron observables of interest are most likely due to the treatment of fission event generation in each of the different codes, as opposed to the radiation transport.« less

  16. Validating the performance of correlated fission multiplicity implementation in radiation transport codes with subcritical neutron multiplication benchmark experiments

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Arthur, Jennifer; Bahran, Rian; Hutchinson, Jesson

    Historically, radiation transport codes have uncorrelated fission emissions. In reality, the particles emitted by both spontaneous and induced fissions are correlated in time, energy, angle, and multiplicity. This work validates the performance of various current Monte Carlo codes that take into account the underlying correlated physics of fission neutrons, specifically neutron multiplicity distributions. The performance of 4 Monte Carlo codes - MCNP®6.2, MCNP®6.2/FREYA, MCNP®6.2/CGMF, and PoliMi - was assessed using neutron multiplicity benchmark experiments. In addition, MCNP®6.2 simulations were run using JEFF-3.2 and JENDL-4.0, rather than ENDF/B-VII.1, data for 239Pu and 240Pu. The sensitive benchmark parameters that in this workmore » represent the performance of each correlated fission multiplicity Monte Carlo code include the singles rate, the doubles rate, leakage multiplication, and Feynman histograms. Although it is difficult to determine which radiation transport code shows the best overall performance in simulating subcritical neutron multiplication inference benchmark measurements, it is clear that correlations exist between the underlying nuclear data utilized by (or generated by) the various codes, and the correlated neutron observables of interest. This could prove useful in nuclear data validation and evaluation applications, in which a particular moment of the neutron multiplicity distribution is of more interest than the other moments. It is also quite clear that, because transport is handled by MCNP®6.2 in 3 of the 4 codes, with the 4th code (PoliMi) being based on an older version of MCNP®, the differences in correlated neutron observables of interest are most likely due to the treatment of fission event generation in each of the different codes, as opposed to the radiation transport.« less

  17. Can 3D Gamified Simulations Be Valid Vocational Training Tools for Persons with Intellectual Disability? An Experiment Based on a Real-life Situation.

    PubMed

    von Barnekow, Ariel; Bonet-Codina, Núria; Tost, Dani

    2017-03-23

    To investigate if 3D gamified simulations can be valid vocational training tools for persons with intellectual disability. A 3D gamified simulation composed by a set of training tasks for cleaning in hostelry was developed in collaboration with professionals of a real hostel and pedagogues of a special needs school. The learning objectives focus on the acquisition of vocabulary skills, work procedures, social abilities and risk prevention. Several accessibility features were developed to make the tasks easy to do from a technological point-of-view. A pilot experiment was conducted to test the pedagogical efficacy of this tool on intellectually disabled workers and students. User scores in the gamified simulation follow a curve of increasing progression. When confronted with reality, they recognized the scenario and tried to reproduce what they had learned in the simulation. Finally, they were interested in the tool, they showed a strong feeling of immersion and engagement, and they reported having fun. On the basis of this experiment we believe that 3D gamified simulations can be efficient tools to train social and professional skills of persons with intellectual disabilities contributing thus to foster their social inclusion through work.

  18. VDA, a Method of Choosing a Better Algorithm with Fewer Validations

    PubMed Central

    Kluger, Yuval

    2011-01-01

    The multitude of bioinformatics algorithms designed for performing a particular computational task presents end-users with the problem of selecting the most appropriate computational tool for analyzing their biological data. The choice of the best available method is often based on expensive experimental validation of the results. We propose an approach to design validation sets for method comparison and performance assessment that are effective in terms of cost and discrimination power. Validation Discriminant Analysis (VDA) is a method for designing a minimal validation dataset to allow reliable comparisons between the performances of different algorithms. Implementation of our VDA approach achieves this reduction by selecting predictions that maximize the minimum Hamming distance between algorithmic predictions in the validation set. We show that VDA can be used to correctly rank algorithms according to their performances. These results are further supported by simulations and by realistic algorithmic comparisons in silico. VDA is a novel, cost-efficient method for minimizing the number of validation experiments necessary for reliable performance estimation and fair comparison between algorithms. Our VDA software is available at http://sourceforge.net/projects/klugerlab/files/VDA/ PMID:22046256

  19. Small Particles in Cirrus (SPartICus) and Storm Peak Lab Validation Experiment (StormVEx) Science Final Technical Report

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Mace, Gerald

    The Small Particles in Cirrus (SPartICus) campaign took place from January through June, 2011 and the Storm Peak Lab Cloud Property Validation Experiment (StormVEx) took place from November, 2011 through April, 2012. The PI of this project, Dr. Gerald Mace, had the privilege to be the lead on both of these campaigns. The essence of the project that we report on here was to conduct preliminary work that was necessary to bring the field data sets to a point where they could be used for their intended science purposes

  20. Coping With Existential and Emotional Challenges: Development and Validation of the Self-Competence in Death Work Scale.

    PubMed

    Chan, Wallace Chi Ho; Tin, Agnes Fong; Wong, Karen Lok Yi

    2015-07-01

    Palliative care professionals often are confronted by death in their work. They may experience challenges to self, such as aroused emotions and queries about life's meaningfulness. Assessing their level of "self-competence" in coping with these challenges is crucial in understanding their needs in death work. This study aims to develop and validate the Self-Competence in Death Work Scale (SC-DWS). Development of this scale involved three steps: 1) items generated from a qualitative study with palliative care professionals, (2) expert panel review, and (3) pilot test. Analysis was conducted to explore the factor structure and examine the reliability and validity of the scale. Helping professionals involved in death work were recruited to complete questionnaires comprising the SC-DWS and other scales. A total of 151 participants were recruited. Both one-factor and two-factor structures were found. Emotional and existential coping were identified as subscales in the two-factor structure. Correlations of the whole scale and subscales with measures of death attitudes, meaning in life, burnout and depression provided evidence for the construct validity. Discriminative validity was supported by showing participants with bereavement experience and longer experience in the profession and death work possessed a significantly higher level of self-competence. Reliability analyses showed that the entire scale and subscales were internally consistent. The SC-DWS was found to be valid and reliable. This scale may facilitate helping professionals' understanding of their self-competence in death work, so appropriate professional support and training may be obtained. Copyright © 2015 American Academy of Hospice and Palliative Medicine. Published by Elsevier Inc. All rights reserved.

  1. Modified Moral Distress Scale (MDS-11): Validation Study Among Italian Nurses.

    PubMed

    Badolamenti, Sondra; Fida, Roberto; Biagioli, Valentina; Caruso, Rosario; Zaghini, Francesco; Sili, Alessandro; Rea, Teresa

    2017-01-01

    Moral distress (MD) has significant implications on individual and organizational health. However there is a lack of an instrument to assess it among Italian nurses. The main aim of this study was to validate a brief instrument to assess MD, developed from the Corley's Moral Distress Scale (MDS). The modified MDS scale was subjected to content and cultural validity. The scale was administered to 347 nurses. Psychometric analysis were performed to assess construct validity. The scale consists of 11 items, investigating MD in nursing practice in different clinical settings. The dimensionality of the scale was investigated through exploratory factor analysis (EFA), which showed a two-dimensional structure labeled futility and potential damage. The futility refers to feelings of powerlessness and ineffectiveness in some clinical situations; the potential damage dimension captures feelings of powerlessness when nurses are forced to tolerate or perform perceived abusive clinical proceedings. Nurses who experienced higher MD, were more lilely to experience burnout. The modified MDS showed good psychometric properties, and it is valid and reliable for assessing moral distress among Italian nurses. Hence, the modified MDS allows to monitor the distress experienced by nurses and it is an important contribution to the scientific community and all those dealing with well-being of health workers.

  2. The influence of work personality on job satisfaction: incremental validity and mediation effects.

    PubMed

    Heller, Daniel; Ferris, D Lance; Brown, Douglas; Watson, David

    2009-08-01

    Drawing from recent developments regarding the contextual nature of personality (e.g., D. Wood & B. W. Roberts, 2006), we conducted 2 studies (1 cross-sectional and 1 longitudinal over 1 year) to examine the validity of work personality in predicting job satisfaction and its mediation of the effect of global personality on job satisfaction. Study 1 showed that (a) individuals vary systematically in their personality between roles- they were significantly more conscientious and open to experience and less extraverted at work compared to at home; (b) work personality was a better predictor of job satisfaction than both global personality and home personality; and (c) work personality demonstrated incremental validity above and beyond the other two personality measures. Study 2 further showed that each of the work personality dimensions fully mediated the association between its corresponding global personality trait and job satisfaction. Evidence for the discriminant validity of the findings is also presented.

  3. Real-time remote scientific model validation

    NASA Technical Reports Server (NTRS)

    Frainier, Richard; Groleau, Nicolas

    1994-01-01

    This paper describes flight results from the use of a CLIPS-based validation facility to compare analyzed data from a space life sciences (SLS) experiment to an investigator's preflight model. The comparison, performed in real-time, either confirms or refutes the model and its predictions. This result then becomes the basis for continuing or modifying the investigator's experiment protocol. Typically, neither the astronaut crew in Spacelab nor the ground-based investigator team are able to react to their experiment data in real time. This facility, part of a larger science advisor system called Principal Investigator in a Box, was flown on the space shuttle in October, 1993. The software system aided the conduct of a human vestibular physiology experiment and was able to outperform humans in the tasks of data integrity assurance, data analysis, and scientific model validation. Of twelve preflight hypotheses associated with investigator's model, seven were confirmed and five were rejected or compromised.

  4. The virtual lover: variable and easily guided 3D fish animations as an innovative tool in mate-choice experiments with sailfin mollies-II. Validation

    PubMed Central

    Müller, Klaus; Smielik, Ievgen; Hütwohl, Jan-Marco; Kuhnert, Klaus-Dieter; Witte, Klaudia

    2017-01-01

    Abstract The use of computer animation in behavioral research is a state-of-the-art method for designing and presenting animated animals to live test animals. The major advantages of computer animations are: (1) the creation of animated animal stimuli with high variability of morphology and even behavior; (2) animated stimuli provide highly standardized, controlled and repeatable testing procedures; and (3) they allow a reduction in the number of live test animals regarding the 3Rs principle. But the use of animated animals should be attended by a thorough validation for each test species to verify that behavior measured with live animals toward virtual animals can also be expected with natural stimuli. Here we present results on the validation of a custom-made simulation for animated 3D sailfin mollies Poecilia latipinna and show that responses of live test females were as strong to an animated fish as to a video or a live male fish. Movement of an animated stimulus was important but female response was stronger toward a swimming 3D fish stimulus than to a “swimming” box. Moreover, male test fish were able to discriminate between animated male and female stimuli; hence, rendering the animated 3D fish a useful tool in mate-choice experiments with sailfin mollies. PMID:29491964

  5. The virtual lover: variable and easily guided 3D fish animations as an innovative tool in mate-choice experiments with sailfin mollies-II. Validation.

    PubMed

    Gierszewski, Stefanie; Müller, Klaus; Smielik, Ievgen; Hütwohl, Jan-Marco; Kuhnert, Klaus-Dieter; Witte, Klaudia

    2017-02-01

    The use of computer animation in behavioral research is a state-of-the-art method for designing and presenting animated animals to live test animals. The major advantages of computer animations are: (1) the creation of animated animal stimuli with high variability of morphology and even behavior; (2) animated stimuli provide highly standardized, controlled and repeatable testing procedures; and (3) they allow a reduction in the number of live test animals regarding the 3Rs principle. But the use of animated animals should be attended by a thorough validation for each test species to verify that behavior measured with live animals toward virtual animals can also be expected with natural stimuli. Here we present results on the validation of a custom-made simulation for animated 3D sailfin mollies Poecilia latipinna and show that responses of live test females were as strong to an animated fish as to a video or a live male fish. Movement of an animated stimulus was important but female response was stronger toward a swimming 3D fish stimulus than to a "swimming" box. Moreover, male test fish were able to discriminate between animated male and female stimuli; hence, rendering the animated 3D fish a useful tool in mate-choice experiments with sailfin mollies.

  6. Validating Remotely Sensed Land Surface Evapotranspiration Based on Multi-scale Field Measurements

    NASA Astrophysics Data System (ADS)

    Jia, Z.; Liu, S.; Ziwei, X.; Liang, S.

    2012-12-01

    validation experiments demonstrated that the models yield accurate estimates at flux measurement sites, the question remains whether they are performing well over the broader landscape. Moreover, a large number of RS_ET products have been released in recent years. Thus, we also pay attention to the cross-validation method of RS_ET derived from multi-source models. "The Multi-scale Observation Experiment on Evapotranspiration over Heterogeneous Land Surfaces: Flux Observation Matrix" campaign is carried out at the middle reaches of the Heihe River Basin, China in 2012. Flux measurements from an observation matrix composed of 22 EC and 4 LAS are acquired to investigate the cross-validation of multi-source models over different landscapes. In this case, six remote sensing models, including the empirical statistical model, the one-source and two-source models, the Penman-Monteith equation based model, the Priestley-Taylor equation based model, and the complementary relationship based model, are used to perform an intercomparison. All the results from the two cases of RS_ET validation showed that the proposed validation methods are reasonable and feasible.

  7. Heart rate variability indicates emotional value during pro-social economic laboratory decisions with large external validity.

    PubMed

    Fooken, Jonas

    2017-03-10

    The present study investigates the external validity of emotional value measured in economic laboratory experiments by using a physiological indicator of stress, heart rate variability (HRV). While there is ample evidence supporting the external validity of economic experiments, there is little evidence comparing the magnitude of internal levels of emotional stress during decision making with external stress. The current study addresses this gap by comparing the magnitudes of decision stress experienced in the laboratory with the stress from outside the laboratory. To quantify a large change in HRV, measures observed in the laboratory during decision-making are compared to the difference between HRV during a university exam and other mental activity for the same individuals in and outside of the laboratory. The results outside the laboratory inform about the relevance of laboratory findings in terms of their relative magnitude. Results show that psychologically induced HRV changes observed in the laboratory, particularly in connection with social preferences, correspond to large effects outside. This underscores the external validity of laboratory findings and shows the magnitude of emotional value connected to pro-social economic decisions in the laboratory.

  8. The Multidimensional Loss Scale: validating a cross-cultural instrument for measuring loss.

    PubMed

    Vromans, Lyn; Schweitzer, Robert D; Brough, Mark

    2012-04-01

    The Multidimensional Loss Scale (MLS) represents the first instrument designed specifically to index Experience of Loss Events and Loss Distress across multiple domains (cultural, social, material, and intrapersonal) relevant to refugee settlement. Recently settled Burmese adult refugees (N = 70) completed a questionnaire battery, including MLS items. Analyses explored MLS internal consistency, convergent and divergent validity, and factor structure. Cronbach alphas indicated satisfactory internal consistency for Experience of Loss Events (0.85) and Loss Distress (0.92), reflecting a unitary construct of multidimensional loss. Loss Distress did not correlate with depression or anxiety symptoms and correlated moderately with interpersonal grief and trauma symptoms, supporting divergent and convergent validity. Factor analysis provided preliminary support for a five-factor model: Loss of Symbolic Self, Loss of Interdependence, Loss of Home, Interpersonal Loss, and Loss of Intrapersonal Integrity. Received well by participants, the new scale shows promise for application in future research and practice.

  9. Validation of the Family Inpatient Communication Survey.

    PubMed

    Torke, Alexia M; Monahan, Patrick; Callahan, Christopher M; Helft, Paul R; Sachs, Greg A; Wocial, Lucia D; Slaven, James E; Montz, Kianna; Inger, Lev; Burke, Emily S

    2017-01-01

    Although many family members who make surrogate decisions report problems with communication, there is no validated instrument to accurately measure surrogate/clinician communication for older adults in the acute hospital setting. The objective of this study was to validate a survey of surrogate-rated communication quality in the hospital that would be useful to clinicians, researchers, and health systems. After expert review and cognitive interviewing (n = 10 surrogates), we enrolled 350 surrogates (250 development sample and 100 validation sample) of hospitalized adults aged 65 years and older from three hospitals in one metropolitan area. The communication survey and a measure of decision quality were administered within hospital days 3 and 10. Mental health and satisfaction measures were administered six to eight weeks later. Factor analysis showed support for both one-factor (Total Communication) and two-factor models (Information and Emotional Support). Item reduction led to a final 30-item scale. For the validation sample, internal reliability (Cronbach's alpha) was 0.96 (total), 0.94 (Information), and 0.90 (Emotional Support). Confirmatory factor analysis fit statistics were adequate (one-factor model, comparative fit index = 0.981, root mean square error of approximation = 0.62, weighted root mean square residual = 1.011; two-factor model comparative fit index = 0.984, root mean square error of approximation = 0.055, weighted root mean square residual = 0.930). Total score and subscales showed significant associations with the Decision Conflict Scale (Pearson correlation -0.43, P < 0.001 for total score). Emotional Support was associated with improved mental health outcomes at six to eight weeks, such as anxiety (-0.19 P < 0.001), and Information was associated with satisfaction with the hospital stay (0.49, P < 0.001). The survey shows high reliability and validity in measuring communication experiences for hospital surrogates. The

  10. Complementary and Alternative Medicine: Italian Validation of a Questionnaire on Nurses' Personal and Professional Use, Knowledge, and Attitudes.

    PubMed

    Belletti, Giada; Shorofi, Seyed Afshin; Arbon, Paul; Dal Molin, Alberto

    2017-08-01

    Patients are showing an increasing interest in the use of complementary and alternative medicine (CAM). Most nurses are open to the adoption of CAM into clinical nursing practice, but they may experience a lack of knowledge about the safe and effective use of these therapies. Several studies concerning nurses' knowledge and attitudes toward CAM have been published, but only in one, the authors (Shorofi and Arbon) used a validated questionnaire. In Italy, there are no validated questionnaires to investigate this aspect of nursing practice. To test the psychometric properties of the Italian Shorofi and Arbon questionnaire for use with Italian nurses. A forward-backward translation method was used to translate the questionnaire from English to Italian. Content validity, face validity and reliability were established. This study examined the potential usefulness of the Shorofi and Arbon questionnaire for the evaluation of CAM knowledge of Italian speaking nurses, which showed good content validity and good reliability.

  11. Hey Teacher, Your Personality's Showing!

    ERIC Educational Resources Information Center

    Paulsen, James R.

    1977-01-01

    A study of 30 fourth, fifth, and sixth grade teachers and 300 of their students showed that a teacher's age, sex, and years of experience did not relate to students' mathematics achievement, but that more effective teachers showed greater "freedom from defensive behavior" than did less effective teachers. (DT)

  12. CosmoQuest:Using Data Validation for More Than Just Data Validation

    NASA Astrophysics Data System (ADS)

    Lehan, C.; Gay, P.

    2016-12-01

    It is often taken for granted that different scientists completing the same task (e.g. mapping geologic features) will get the same results, and data validation is often skipped or under-utilized due to time and funding constraints. Robbins et. al (2014), however, demonstrated that this is a needed step, as large variation can exist even among collaborating team members completing straight-forward tasks like marking craters. Data Validation should be much more than a simple post-project verification of results. The CosmoQuest virtual research facility employs regular data-validation for a variety of benefits, including real-time user feedback, real-time tracking to observe user activity while it's happening, and using pre-solved data to analyze users' progress and to help them retain skills. Some creativity in this area can drastically improve project results. We discuss methods of validating data in citizen science projects and outline the variety of uses for validation, which, when used properly, improves the scientific output of the project and the user experience for the citizens doing the work. More than just a tool for scientists, validation can assist users in both learning and retaining important information and skills, improving the quality and quantity of data gathered. Real-time analysis of user data can give key information in the effectiveness of the project that a broad glance would miss, and properly presenting that analysis is vital. Training users to validate their own data, or the data of others, can significantly improve the accuracy of misinformed or novice users.

  13. Reflective oxygen saturation monitoring at hypothenar and its validation by human hypoxia experiment.

    PubMed

    Guo, Tao; Cao, Zhengtao; Zhang, Zhengbo; Li, Deyu; Yu, Mengsun

    2015-08-05

    Pulse oxygen saturation (SpO2) is an important parameter for healthcare, and wearable sensors and systems for SpO2 monitoring have become increasingly popular. The aim of this paper is to develop a novel SpO2 monitoring system, which detects photoplethysmographic (PPG) signals at hypothenar with a reflection-mode sensor embedded into a glove. A special photo-detector section was designed with two photodiodes arranged symmetrically to the red and infrared light-emitting diodes (LED) to enhance the signal quality. The reflective sensor was placed in a soft silicon substrate sewn in a glove to fit the surface of the hypothenar. To lower the power consumption, the LED driving current was reduced and energy-efficient electronic components were applied. The performance for PPG signal detection and SpO2 monitoring was evaluated by human hypoxia experiments. Accelerometer-based adaptive noise cancellation (ANC) methods applying the least mean squares (LMS) and recursive least squares (RLS) algorithms were studied to suppress motion artifact. A total of 20 subjects participated in the hypoxia experiment. The degree of comfort for wearing this system was accepted by them. The PPG signals were detected effectively at SpO2 levels from about 100-70%. The experiment validated the accuracy of the system was 2.34%, compared to the invasive measurements. Both the LMS and RLS algorithms improved the performance during motion. The total current consumed by the system was only 8 mA. It is feasible to detect PPG signal and monitor SpO2 at the location of hypothenar. This novel system can achieve reliable SpO2 measurements at different SpO2 levels and on different individuals. The system is light-weighted, easy to wear and power-saving. It has the potential to be a solution for wearable monitoring, although more work should be conducted to improve the motion-resistant performance significantly.

  14. Preliminary Results from the GPS-Reflections Mediterranean Balloon Experiment (GPSR-MEBEX)

    NASA Technical Reports Server (NTRS)

    Garrison, James L.; Ruffini, Giulio; Rius, Antonio; Cardellach, Estelle; Masters, Dallas; Armatys, Michael; Zavorotny, Valery; Bauer, Frank H. (Technical Monitor)

    2000-01-01

    An experiment to collect bistatically scattered GPS signals from a balloon at 37 km altitude has been conducted. This experiment represented the highest altitude to date that such signals were successfully recorded. The flight took place in August 1999 over the Mediterranean sea, between a launch in Sicily and recovery near Nerpio, a town in the Sierra de Segura, Albacete province of Huelva, Spain. Results from this experiment are presented, showing the waveform shape as compared to theoretical calculations. These results will be used to validate analytical models which form the basis of wind vector retrieval algorithms. These algorithms are already being validated from aircraft altitudes, but may be applied to data from future spacebourne GPS receivers. Surface wind data from radiosondes were used for comparison. This experiment was a cooperative project between NASA, the IEEC in Barcelona, and the University of Colorado at Boulder.

  15. Preliminary Results from the GPS-Reflections Mediterranean Balloon Experiment (GPSR MEBEX)

    NASA Technical Reports Server (NTRS)

    Garrison, James L.; Ruffini, Giulio; Rius, Antonio; Cardellach, Estelle; Masters, Dallas; Armathys, Michael; Zavorotny, Valery

    2000-01-01

    An experiment to collect bistatically scattered GPS signals from a balloon at 37 km altitude has been conducted. This experiment represented the highest altitude to date that such signals were successfully recorded. The flight took place in August 1999 over the Mediterranean sea, between a launch in Sicily and recovery near Nerpio, a town in the Sierra de Segura, Albacete province of Huelva, Spain. Results from this experiment are presented, showing the waveform shape as compared to theoretical calculations. These results will be used to validate analytical models which form the basis of wind vector retrieval algorithms. These algorithms are already being validated from aircraft altitudes, but may be applied to data from future spaceborne GPS receivers. Surface wind data from radiosondes were used for comparison. This experiment was a cooperative project between NASA, the IEEC in Barcelona, and the University of Colorado at Boulder.

  16. A French validation study of the Coma Recovery Scale-Revised (CRS-R).

    PubMed

    Schnakers, Caroline; Majerus, Steve; Giacino, Joseph; Vanhaudenhuyse, Audrey; Bruno, Marie-Aurelie; Boly, Melanie; Moonen, Gustave; Damas, Pierre; Lambermont, Bernard; Lamy, Maurice; Damas, Francois; Ventura, Manfredi; Laureys, Steven

    2008-09-01

    The aim of the present study was to explore the concurrent validity, inter-rater agreement and diagnostic sensitivity of a French adaptation of the Coma Recovery Scale-Revised (CRS-R) as compared to other coma scales such as the Glasgow Coma Scale (GCS), the Full Outline of UnResponsiveness scale (FOUR) and the Wessex Head Injury Matrix (WHIM). Multi-centric prospective study. To test concurrent validity and diagnostic sensitivity, the four behavioural scales were administered in a randomized order in 77 vegetative and minimally conscious patients. Twenty-four clinicians with different professional backgrounds, levels of expertise and CRS-R experience were recruited to assess inter-rater agreement. Good concurrent validity was obtained between the CRS-R and the three other standardized behavioural scales. Inter-rater reliability for the CRS-R total score and sub-scores was good, indicating that the scale yields reproducible findings across examiners and does not appear to be systematically biased by profession, level of expertise or CRS-R experience. Finally, the CRS-R demonstrated a significantly higher sensitivity to detect MCS patients, as compared to the GCS, the FOUR and the WHIM. The results show that the French version of the CRS-R is a valid and sensitive scale which can be used in severely brain damaged patients by all members of the medical staff.

  17. Use of the FDA nozzle model to illustrate validation techniques in computational fluid dynamics (CFD) simulations.

    PubMed

    Hariharan, Prasanna; D'Souza, Gavin A; Horner, Marc; Morrison, Tina M; Malinauskas, Richard A; Myers, Matthew R

    2017-01-01

    A "credible" computational fluid dynamics (CFD) model has the potential to provide a meaningful evaluation of safety in medical devices. One major challenge in establishing "model credibility" is to determine the required degree of similarity between the model and experimental results for the model to be considered sufficiently validated. This study proposes a "threshold-based" validation approach that provides a well-defined acceptance criteria, which is a function of how close the simulation and experimental results are to the safety threshold, for establishing the model validity. The validation criteria developed following the threshold approach is not only a function of Comparison Error, E (which is the difference between experiments and simulations) but also takes in to account the risk to patient safety because of E. The method is applicable for scenarios in which a safety threshold can be clearly defined (e.g., the viscous shear-stress threshold for hemolysis in blood contacting devices). The applicability of the new validation approach was tested on the FDA nozzle geometry. The context of use (COU) was to evaluate if the instantaneous viscous shear stress in the nozzle geometry at Reynolds numbers (Re) of 3500 and 6500 was below the commonly accepted threshold for hemolysis. The CFD results ("S") of velocity and viscous shear stress were compared with inter-laboratory experimental measurements ("D"). The uncertainties in the CFD and experimental results due to input parameter uncertainties were quantified following the ASME V&V 20 standard. The CFD models for both Re = 3500 and 6500 could not be sufficiently validated by performing a direct comparison between CFD and experimental results using the Student's t-test. However, following the threshold-based approach, a Student's t-test comparing |S-D| and |Threshold-S| showed that relative to the threshold, the CFD and experimental datasets for Re = 3500 were statistically similar and the model could be

  18. Face validation of the Virtual Electrosurgery Skill Trainer (VEST©).

    PubMed

    Sankaranarayanan, Ganesh; Li, Baichun; Miller, Amie; Wakily, Hussna; Jones, Stephanie B; Schwaitzberg, Steven; Jones, Daniel B; De, Suvranu; Olasky, Jaisa

    2016-02-01

    Electrosurgery is a modality that is widely used in surgery, whose use has resulted in injuries, OR fires and even death. The SAGES has established the FUSE program to address the knowledge gap in the proper and safe usage of electrosurgical devices. Complementing it, we have developed the Virtual Electrosurgery Skill Trainer (VEST(©)), which is designed to train subjects in both cognitive and motor skills necessary to safely operate electrosurgical devices. The objective of this study is to asses the face validity of the VEST(©) simulator. Sixty-three subjects were recruited at the 2014 SAGES Learning Center. They all completed the monopolar electrosurgery module on the VEST(©) simulator. At the end of the study, subjects assessed the face validity with questions that were scored on a 5-point Likert scale. The subjects were divided into two groups; FUSE experience (n = 15) and no FUSE experience (n = 48). The median score for both the groups was 4 or higher on all questions and 5 on questions on effectiveness of VEST(©) in aiding learning electrosurgery fundamentals. Questions on using the simulator in their own skills lab and recommending it to their peers also scored at 5. Mann-Whitney U test showed no significant difference (p > 0.05) indicating a general agreement. 46% of the respondents preferred VEST compared with 52% who preferred animal model and 2% preferred both for training in electrosurgery. This study demonstrated the face validity of the VEST(©) simulator. High scores showed that the simulator was visually realistic and reproduced lifelike tissue effects and the features were adequate enough to provide high realism. The self-learning instructional material was also found to be very useful in learning the fundamentals of electrosurgery. Adding more modules would increase the applicability of the VEST(©) simulator.

  19. Face Validation of the Virtual Electrosurgery Skill Trainer (VEST©)

    PubMed Central

    Sankaranarayanan, Ganesh; Li, Baichun; Miller, Amie; Wakily, Hussna; Jones, Stephanie B.; Schwaitzberg, Steven; Jones, Daniel B.; De, Suvranu; Olasky, Jaisa

    2015-01-01

    Background Electrosurgery is a modality that is widely used in surgery, whose use has resulted in injuries, OR fires and even death. The SAGES has established the FUSE program to address the knowledge gap in the proper and safe usage of electrosurgical devices. Complementing it, we have developed the Virtual Electrosurgery Skill Trainer (VEST©), which is designed to train subjects in both cognitive and motor skills necessary to safely operate electrosurgical devices. The objective of this study is to asses the face validity of the VEST© simulator. Methods Sixty-three subjects were recruited at the 2014 SAGES Learning Center. They all completed the monopolar electrosurgery module on the VEST© simulator. At the end of the study, subjects assessed the face validity with questions that were scored on a 5-point Likert scale. Results The subjects were divided into two groups; FUSE experience (n = 15) and no FUSE experience (n = 48). The median score for both the groups was 4 or higher on all questions and 5 on questions on effectiveness of VEST© in aiding learning electrosurgery fundamentals. Questions on using the simulator in their own skills lab and recommending it to their peers also scored at 5. Mann-Whitney U test showed no significant difference (p > 0.05) indicating a general agreement. 46 % of the respondents preferred VEST compared to 52 % who preferred animal model and 2 % preferred both for training in electrosurgery. Conclusion This study demonstrated the face validity of the VEST © simulator. High scores showed that the simulator was visually realistic and reproduced lifelike tissue effects and the features were adequate enough to provide high realism. The self-learning instructional material was also found to be very useful in learning the fundamentals of electrosurgery. Adding more modules would increase the applicability of the VEST© simulator. PMID:26092003

  20. Construct validity of individual and summary performance metrics associated with a computer-based laparoscopic simulator.

    PubMed

    Rivard, Justin D; Vergis, Ashley S; Unger, Bertram J; Hardy, Krista M; Andrew, Chris G; Gillman, Lawrence M; Park, Jason

    2014-06-01

    Computer-based surgical simulators capture a multitude of metrics based on different aspects of performance, such as speed, accuracy, and movement efficiency. However, without rigorous assessment, it may be unclear whether all, some, or none of these metrics actually reflect technical skill, which can compromise educational efforts on these simulators. We assessed the construct validity of individual performance metrics on the LapVR simulator (Immersion Medical, San Jose, CA, USA) and used these data to create task-specific summary metrics. Medical students with no prior laparoscopic experience (novices, N = 12), junior surgical residents with some laparoscopic experience (intermediates, N = 12), and experienced surgeons (experts, N = 11) all completed three repetitions of four LapVR simulator tasks. The tasks included three basic skills (peg transfer, cutting, clipping) and one procedural skill (adhesiolysis). We selected 36 individual metrics on the four tasks that assessed six different aspects of performance, including speed, motion path length, respect for tissue, accuracy, task-specific errors, and successful task completion. Four of seven individual metrics assessed for peg transfer, six of ten metrics for cutting, four of nine metrics for clipping, and three of ten metrics for adhesiolysis discriminated between experience levels. Time and motion path length were significant on all four tasks. We used the validated individual metrics to create summary equations for each task, which successfully distinguished between the different experience levels. Educators should maintain some skepticism when reviewing the plethora of metrics captured by computer-based simulators, as some but not all are valid. We showed the construct validity of a limited number of individual metrics and developed summary metrics for the LapVR. The summary metrics provide a succinct way of assessing skill with a single metric for each task, but require further validation.

  1. Cloud computing and validation of expandable in silico livers

    PubMed Central

    2010-01-01

    Background In Silico Livers (ISLs) are works in progress. They are used to challenge multilevel, multi-attribute, mechanistic hypotheses about the hepatic disposition of xenobiotics coupled with hepatic responses. To enhance ISL-to-liver mappings, we added discrete time metabolism, biliary elimination, and bolus dosing features to a previously validated ISL and initiated re-validated experiments that required scaling experiments to use more simulated lobules than previously, more than could be achieved using the local cluster technology. Rather than dramatically increasing the size of our local cluster we undertook the re-validation experiments using the Amazon EC2 cloud platform. So doing required demonstrating the efficacy of scaling a simulation to use more cluster nodes and assessing the scientific equivalence of local cluster validation experiments with those executed using the cloud platform. Results The local cluster technology was duplicated in the Amazon EC2 cloud platform. Synthetic modeling protocols were followed to identify a successful parameterization. Experiment sample sizes (number of simulated lobules) on both platforms were 49, 70, 84, and 152 (cloud only). Experimental indistinguishability was demonstrated for ISL outflow profiles of diltiazem using both platforms for experiments consisting of 84 or more samples. The process was analogous to demonstration of results equivalency from two different wet-labs. Conclusions The results provide additional evidence that disposition simulations using ISLs can cover the behavior space of liver experiments in distinct experimental contexts (there is in silico-to-wet-lab phenotype similarity). The scientific value of experimenting with multiscale biomedical models has been limited to research groups with access to computer clusters. The availability of cloud technology coupled with the evidence of scientific equivalency has lowered the barrier and will greatly facilitate model sharing as well as provide

  2. Cloud computing and validation of expandable in silico livers.

    PubMed

    Ropella, Glen E P; Hunt, C Anthony

    2010-12-03

    In Silico Livers (ISLs) are works in progress. They are used to challenge multilevel, multi-attribute, mechanistic hypotheses about the hepatic disposition of xenobiotics coupled with hepatic responses. To enhance ISL-to-liver mappings, we added discrete time metabolism, biliary elimination, and bolus dosing features to a previously validated ISL and initiated re-validated experiments that required scaling experiments to use more simulated lobules than previously, more than could be achieved using the local cluster technology. Rather than dramatically increasing the size of our local cluster we undertook the re-validation experiments using the Amazon EC2 cloud platform. So doing required demonstrating the efficacy of scaling a simulation to use more cluster nodes and assessing the scientific equivalence of local cluster validation experiments with those executed using the cloud platform. The local cluster technology was duplicated in the Amazon EC2 cloud platform. Synthetic modeling protocols were followed to identify a successful parameterization. Experiment sample sizes (number of simulated lobules) on both platforms were 49, 70, 84, and 152 (cloud only). Experimental indistinguishability was demonstrated for ISL outflow profiles of diltiazem using both platforms for experiments consisting of 84 or more samples. The process was analogous to demonstration of results equivalency from two different wet-labs. The results provide additional evidence that disposition simulations using ISLs can cover the behavior space of liver experiments in distinct experimental contexts (there is in silico-to-wet-lab phenotype similarity). The scientific value of experimenting with multiscale biomedical models has been limited to research groups with access to computer clusters. The availability of cloud technology coupled with the evidence of scientific equivalency has lowered the barrier and will greatly facilitate model sharing as well as provide straightforward tools for scaling

  3. Patient Experience and Satisfaction with Inpatient Service: Development of Short Form Survey Instrument Measuring the Core Aspect of Inpatient Experience

    PubMed Central

    Wong, Eliza L. Y.; Coulter, Angela; Hewitson, Paul; Cheung, Annie W. L.; Yam, Carrie H. K.; Lui, Siu fai; Tam, Wilson W. S.; Yeoh, Eng-kiong

    2015-01-01

    Patient experience reflects quality of care from the patients’ perspective; therefore, patients’ experiences are important data in the evaluation of the quality of health services. The development of an abbreviated, reliable and valid instrument for measuring inpatients’ experience would reflect the key aspect of inpatient care from patients’ perspective as well as facilitate quality improvement by cultivating patient engagement and allow the trends in patient satisfaction and experience to be measured regularly. The study developed a short-form inpatient instrument and tested its ability to capture a core set of inpatients’ experiences. The Hong Kong Inpatient Experience Questionnaire (HKIEQ) was established in 2010; it is an adaptation of the General Inpatient Questionnaire of the Care Quality Commission created by the Picker Institute in United Kingdom. This study used a consensus conference and a cross-sectional validation survey to create and validate a short-form of the Hong Kong Inpatient Experience Questionnaire (SF-HKIEQ). The short-form, the SF-HKIEQ, consisted of 18 items derived from the HKIEQ. The 18 items mainly covered relational aspects of care under four dimensions of the patient’s journey: hospital staff, patient care and treatment, information on leaving the hospital, and overall impression. The SF-HKIEQ had a high degree of face validity, construct validity and internal reliability. The validated SF-HKIEQ reflects the relevant core aspects of inpatients’ experience in a hospital setting. It provides a quick reference tool for quality improvement purposes and a platform that allows both healthcare staff and patients to monitor the quality of hospital care over time. PMID:25860775

  4. Design and validation of the Health Professionals' Attitudes Toward the Homeless Inventory (HPATHI).

    PubMed

    Buck, David S; Monteiro, F Marconi; Kneuper, Suzanne; Rochon, Donna; Clark, Dana L; Melillo, Allegra; Volk, Robert J

    2005-01-10

    Recent literature has called for humanistic care of patients and for medical schools to begin incorporating humanism into medical education. To assess the attitudes of health-care professionals toward homeless patients and to demonstrate how those attitudes might impact optimal care, we developed and validated a new survey instrument, the Health Professional Attitudes Toward the Homeless Inventory (HPATHI). An instrument that measures providers' attitudes toward the homeless could offer meaningful information for the design and implementation of educational activities that foster more compassionate homeless health care. Our intention was to describe the process of designing and validating the new instrument and to discuss the usefulness of the instrument for assessing the impact of educational experiences that involve working directly with the homeless on the attitudes, interest, and confidence of medical students and other health-care professionals. The study consisted of three phases: identifying items for the instrument; pilot testing the initial instrument with a group of 72 third-year medical students; and modifying and administering the instrument in its revised form to 160 health-care professionals and third-year medical students. The instrument was analyzed for reliability and validity throughout the process. A 19-item version of the HPATHI had good internal consistency with a Cronbach's alpha of 0.88 and a test-retest reliability coefficient of 0.69. The HPATHI showed good concurrent validity, and respondents with more than one year of experience with homeless patients scored significantly higher than did those with less experience. Factor analysis yielded three subscales: Personal Advocacy, Social Advocacy, and Cynicism. The HPATHI demonstrated strong reliability for the total scale and satisfactory test-retest reliability. Extreme group comparisons suggested that experience with the homeless rather than medical training itself could affect health

  5. Validated simulator for space debris removal with nets and other flexible tethers applications

    NASA Astrophysics Data System (ADS)

    Gołębiowski, Wojciech; Michalczyk, Rafał; Dyrek, Michał; Battista, Umberto; Wormnes, Kjetil

    2016-12-01

    In the context of active debris removal technologies and preparation activities for the e.Deorbit mission, a simulator for net-shaped elastic bodies dynamics and their interactions with rigid bodies, has been developed. Its main application is to aid net design and test scenarios for space debris deorbitation. The simulator can model all the phases of the debris capturing process: net launch, flight and wrapping around the target. It handles coupled simulation of rigid and flexible bodies dynamics. Flexible bodies were implemented using Cosserat rods model. It allows to simulate flexible threads or wires with elasticity and damping for stretching, bending and torsion. Threads may be combined into structures of any topology, so the software is able to simulate nets, pure tethers, tether bundles, cages, trusses, etc. Full contact dynamics was implemented. Programmatic interaction with simulation is possible - i.e. for control implementation. The underlying model has been experimentally validated and due to significant gravity influence, experiment had to be performed in microgravity conditions. Validation experiment for parabolic flight was a downscaled process of Envisat capturing. The prepacked net was launched towards the satellite model, it expanded, hit the model and wrapped around it. The whole process was recorded with 2 fast stereographic camera sets for full 3D trajectory reconstruction. The trajectories were used to compare net dynamics to respective simulations and then to validate the simulation tool. The experiments were performed on board of a Falcon-20 aircraft, operated by National Research Council in Ottawa, Canada. Validation results show that model reflects phenomenon physics accurately enough, so it may be used for scenario evaluation and mission design purposes. The functionalities of the simulator are described in detail in the paper, as well as its underlying model, sample cases and methodology behind validation. Results are presented and

  6. Observations on CFD Verification and Validation from the AIAA Drag Prediction Workshops

    NASA Technical Reports Server (NTRS)

    Morrison, Joseph H.; Kleb, Bil; Vassberg, John C.

    2014-01-01

    The authors provide observations from the AIAA Drag Prediction Workshops that have spanned over a decade and from a recent validation experiment at NASA Langley. These workshops provide an assessment of the predictive capability of forces and moments, focused on drag, for transonic transports. It is very difficult to manage the consistency of results in a workshop setting to perform verification and validation at the scientific level, but it may be sufficient to assess it at the level of practice. Observations thus far: 1) due to simplifications in the workshop test cases, wind tunnel data are not necessarily the “correct” results that CFD should match, 2) an average of core CFD data are not necessarily a better estimate of the true solution as it is merely an average of other solutions and has many coupled sources of variation, 3) outlier solutions should be investigated and understood, and 4) the DPW series does not have the systematic build up and definition on both the computational and experimental side that is required for detailed verification and validation. Several observations regarding the importance of the grid, effects of physical modeling, benefits of open forums, and guidance for validation experiments are discussed. The increased variation in results when predicting regions of flow separation and increased variation due to interaction effects, e.g., fuselage and horizontal tail, point out the need for validation data sets for these important flow phenomena. Experiences with a recent validation experiment at NASA Langley are included to provide guidance on validation experiments.

  7. The correlation of in vivo and ex vivo tissue dielectric properties to validate electromagnetic breast imaging: initial clinical experience

    PubMed Central

    Halter, Ryan J; Zhou, Tian; Meaney, Paul M; Hartov, Alex; Barth, Richard J; Rosenkranz, Kari M; Wells, Wendy A; Kogel, Christine A; Borsic, Andrea; Rizzo, Elizabeth J; Paulsen, Keith D

    2009-01-01

    Electromagnetic (EM) breast imaging provides low-cost, safe and potentially a more specific modality for cancer detection than conventional imaging systems. A primary difficulty in validating these EM imaging modalities is that the true dielectric property values of the particular breast being imaged are not readily available on an individual subject basis. Here, we describe our initial experience in seeking to correlate tomographic EM imaging studies with discrete point spectroscopy measurements of the dielectric properties of breast tissue. The protocol we have developed involves measurement of in vivo tissue properties during partial and full mastectomy procedures in the operating room (OR) followed by ex vivo tissue property recordings in the same locations in the excised tissue specimens in the pathology laboratory immediately after resection. We have successfully applied all of the elements of this validation protocol in a series of six women with cancer diagnoses. Conductivity and permittivity gauged from ex vivo samples over the frequency range 100 Hz–8.5 GHz are found to be similar to those reported in the literature. A decrease in both conductivity and permittivity is observed when these properties are gauged from ex vivo samples instead of in vivo. We present these results in addition to a case study demonstrating how discrete point spectroscopy measurements of the tissue can be correlated and used to validate EM imaging studies. PMID:19491436

  8. Validation of ionospheric electron density profiles inferred from GPS occultation observations of the GPS/MET experiment

    NASA Astrophysics Data System (ADS)

    Kawakami, Todd Mori

    In April of 1995, the launch of the GPS Meteorology Experiment (GPS/MET) onboard the Orbview-1 satellite, formerly known as Microlab-1, provided the first technology demonstration of active limb sounding of the Earth's atmosphere with a low Earth orbiting spacecraft utilizing the signals transmitted by the satellites of the Global Positioning System (GPS). Though the experiment's primary mission was to probe the troposphere and stratosphere, GPS/MET was also capable of making radio occultation observations of the ionosphere. The application of the GPS occultation technique to the upper atmosphere created a unique opportunity to conduct ionospheric research with an unprecedented global distribution of observations. For operational support requirements, the Abel transform could be employed to invert the horizontal TEC profiles computed from the L1 and L2 phase measurements observed by GPS/MET into electron density profiles versus altitude in near real time. The usefulness of the method depends on how effectively the TEC limb profiles can be transformed into vertical electron density profiles. An assessment of GPS/MET's ability to determine electron density profiles needs to be examined to validate the significance of the GPS occultation method as a new and complementary ionospheric research tool to enhance the observational databases and improve space weather modeling and forecasting. To that end, simulations of the occultation observations and their inversions have been conducted to test the Abel transform algorithm and to provide qualitative information about the type and range of errors that might be experienced during the processing of real data. Comparisons of the electron density profiles inferred from real GPS/MET observations are then compared with coincident in situ measurements from the satellites of Defense Meteorological Satellite Program (DMSP) and ground-based remote sensing from digisonde and incoherent scatter radar facilities. The principal focus of

  9. Psychometric Properties of Korean Version of the Second Victim Experience and Support Tool (K-SVEST).

    PubMed

    Kim, Eun-Mi; Kim, Sun-Aee; Lee, Ju-Ry; Burlison, Jonathan D; Oh, Eui Geum

    2018-02-13

    "Second victims" are defined as healthcare professionals whose wellness is influenced by adverse clinical events. The Second Victim Experience and Support Tool (SVEST) was used to measure the second-victim experience and quality of support resources. Although the reliability and validity of the original SVEST have been validated, those for the Korean tool have not been validated. The aim of the study was to evaluate the psychometric properties of the Korean version of the SVEST. The study included 305 clinical nurses as participants. The SVEST was translated into Korean via back translation. Content validity was assessed by seven experts, and test-retest reliability was evaluated by 30 clinicians. Internal consistency and construct validity were assessed via confirmatory factor analysis. The analyses were performed using SPSS 23.0 and STATA 13.0 software. The content validity index value demonstrated validity; item- and scale-level content validity index values were both 0.95. Test-retest reliability and internal consistency reliability were satisfactory: the intraclass consistent coefficient was 0.71, and Cronbach α values ranged from 0.59 to 0.87. The CFA showed a significantly good fit for an eight-factor structure (χ = 578.21, df = 303, comparative fit index = 0.92, Tucker-Lewis index = 0.90, root mean square error of approximation = 0.05). The K-SVEST demonstrated good psychometric properties and adequate validity and reliability. The results showed that the Korean version of SVEST demonstrated the extent of second victimhood and support resources in Korean healthcare workers and could aid in the development of support programs and evaluation of their effectiveness.

  10. Validation of the updated ArthroS simulator: face and construct validity of a passive haptic virtual reality simulator with novel performance metrics.

    PubMed

    Garfjeld Roberts, Patrick; Guyver, Paul; Baldwin, Mathew; Akhtar, Kash; Alvand, Abtin; Price, Andrew J; Rees, Jonathan L

    2017-02-01

    To assess the construct and face validity of ArthroS, a passive haptic VR simulator. A secondary aim was to evaluate the novel performance metrics produced by this simulator. Two groups of 30 participants, each divided into novice, intermediate or expert based on arthroscopic experience, completed three separate tasks on either the knee or shoulder module of the simulator. Performance was recorded using 12 automatically generated performance metrics and video footage of the arthroscopic procedures. The videos were blindly assessed using a validated global rating scale (GRS). Participants completed a survey about the simulator's realism and training utility. This new simulator demonstrated construct validity of its tasks when evaluated against a GRS (p ≤ 0.003 in all cases). Regarding it's automatically generated performance metrics, established outputs such as time taken (p ≤ 0.001) and instrument path length (p ≤ 0.007) also demonstrated good construct validity. However, two-thirds of the proposed 'novel metrics' the simulator reports could not distinguish participants based on arthroscopic experience. Face validity assessment rated the simulator as a realistic and useful tool for trainees, but the passive haptic feedback (a key feature of this simulator) is rated as less realistic. The ArthroS simulator has good task construct validity based on established objective outputs, but some of the novel performance metrics could not distinguish between surgical experience. The passive haptic feedback of the simulator also needs improvement. If simulators could offer automated and validated performance feedback, this would facilitate improvements in the delivery of training by allowing trainees to practise and self-assess.

  11. An Italian multicentre validation study of the coma recovery scale-revised.

    PubMed

    Estraneo, A; Moretta, P; De Tanti, A; Gatta, G; Giacino, J T; Trojano, L

    2015-10-01

    Rate of misdiagnosis of disorders of consciousness (DoC) can be reduced by employing validated clinical diagnostic tools, such as the Coma Recovery Scale-Revised (CRS-R). An Italian version of the CRS-R has been recently developed, but its applicability across different clinical settings, and its concurrent validity and diagnostic sensitivity have not been estimated yet. To perform a multicentre validation study of the Italian version of the Coma Recovery Scale-Revised (CRS-R). Analysis of inter-rater reliability, concurrent validity and diagnostic sensitivity of the scale. One Intensive Care Unit, 8 Post-acute rehabilitation centres and 2 Long-term facilities Twenty-seven professionals (physicians, N.=11; psychologists, N.=5; physiotherapists, N.=3; speech therapists, N.=6; nurses, N.=2) from 11 Italian Centres. CRS-R and Disability Rating Scale (DRS) applied to 122 patients with clinical diagnosis of Vegetative State (VS) or Minimally Conscious State (MCS). CRS-R has good-to-excellent inter-rater reliability for all subscales, particularly for the communication subscale. The Italian version of the CRS-R showed a high sensitivity and specificity in detecting MCS with reference to clinical consensus diagnosis. The CRS-R showed good concurrent validity with the Disability Rating Scale, which had very low specificity with reference to clinical consensus diagnosis. The Italian version of the CRS-R is a valid scale for use from the sub-acute to chronic stages of DoC. It can be administered reliably by all members of the rehabilitation team with different specialties, levels of experience and settings. The present study promote use of the Italian version of the CRS-R to improve diagnosis of DoC patients, and plan tailored rehabilitation treatment.

  12. Three-dimensional localized coherent structures of surface turbulence: Model validation with experiments and further computations.

    PubMed

    Demekhin, E A; Kalaidin, E N; Kalliadasis, S; Vlaskin, S Yu

    2010-09-01

    We validate experimentally the Kapitsa-Shkadov model utilized in the theoretical studies by Demekhin [Phys. Fluids 19, 114103 (2007)10.1063/1.2793148; Phys. Fluids 19, 114104 (2007)]10.1063/1.2793149 of surface turbulence on a thin liquid film flowing down a vertical planar wall. For water at 15° , surface turbulence typically occurs at an inlet Reynolds number of ≃40 . Of particular interest is to assess experimentally the predictions of the model for three-dimensional nonlinear localized coherent structures, which represent elementary processes of surface turbulence. For this purpose we devise simple experiments to investigate the instabilities and transitions leading to such structures. Our experimental results are in good agreement with the theoretical predictions of the model. We also perform time-dependent computations for the formation of coherent structures and their interaction with localized structures of smaller amplitude on the surface of the film.

  13. Analysis of bacterial genomes from an evolution experiment with horizontal gene transfer shows that recombination can sometimes overwhelm selection

    PubMed Central

    2018-01-01

    Few experimental studies have examined the role that sexual recombination plays in bacterial evolution, including the effects of horizontal gene transfer on genome structure. To address this limitation, we analyzed genomes from an experiment in which Escherichia coli K-12 Hfr (high frequency recombination) donors were periodically introduced into 12 evolving populations of E. coli B and allowed to conjugate repeatedly over the course of 1000 generations. Previous analyses of the evolved strains from this experiment showed that recombination did not accelerate adaptation, despite increasing genetic variation relative to asexual controls. However, the resolution in that previous work was limited to only a few genetic markers. We sought to clarify and understand these puzzling results by sequencing complete genomes from each population. The effects of recombination were highly variable: one lineage was mostly derived from the donors, while another acquired almost no donor DNA. In most lineages, some regions showed repeated introgression and others almost none. Regions with high introgression tended to be near the donors’ origin of transfer sites. To determine whether introgressed alleles imposed a genetic load, we extended the experiment for 200 generations without recombination and sequenced whole-population samples. Beneficial alleles in the recipient populations were occasionally driven extinct by maladaptive donor-derived alleles. On balance, our analyses indicate that the plasmid-mediated recombination was sufficiently frequent to drive donor alleles to fixation without providing much, if any, selective advantage. PMID:29385126

  14. Validation of the Vanderbilt Holistic Face Processing Test.

    PubMed

    Wang, Chao-Chih; Ross, David A; Gauthier, Isabel; Richler, Jennifer J

    2016-01-01

    The Vanderbilt Holistic Face Processing Test (VHPT-F) is a new measure of holistic face processing with better psychometric properties relative to prior measures developed for group studies (Richler et al., 2014). In fields where psychologists study individual differences, validation studies are commonplace and the concurrent validity of a new measure is established by comparing it to an older measure with established validity. We follow this approach and test whether the VHPT-F measures the same construct as the composite task, which is group-based measure at the center of the large literature on holistic face processing. In Experiment 1, we found a significant correlation between holistic processing measured in the VHPT-F and the composite task. Although this correlation was small, it was comparable to the correlation between holistic processing measured in the composite task with the same faces, but different target parts (top or bottom), which represents a reasonable upper limit for correlations between the composite task and another measure of holistic processing. These results confirm the validity of the VHPT-F by demonstrating shared variance with another measure of holistic processing based on the same operational definition. These results were replicated in Experiment 2, but only when the demographic profile of our sample matched that of Experiment 1.

  15. Validation of the Vanderbilt Holistic Face Processing Test

    PubMed Central

    Wang, Chao-Chih; Ross, David A.; Gauthier, Isabel; Richler, Jennifer J.

    2016-01-01

    The Vanderbilt Holistic Face Processing Test (VHPT-F) is a new measure of holistic face processing with better psychometric properties relative to prior measures developed for group studies (Richler et al., 2014). In fields where psychologists study individual differences, validation studies are commonplace and the concurrent validity of a new measure is established by comparing it to an older measure with established validity. We follow this approach and test whether the VHPT-F measures the same construct as the composite task, which is group-based measure at the center of the large literature on holistic face processing. In Experiment 1, we found a significant correlation between holistic processing measured in the VHPT-F and the composite task. Although this correlation was small, it was comparable to the correlation between holistic processing measured in the composite task with the same faces, but different target parts (top or bottom), which represents a reasonable upper limit for correlations between the composite task and another measure of holistic processing. These results confirm the validity of the VHPT-F by demonstrating shared variance with another measure of holistic processing based on the same operational definition. These results were replicated in Experiment 2, but only when the demographic profile of our sample matched that of Experiment 1. PMID:27933014

  16. Base Flow Model Validation

    NASA Technical Reports Server (NTRS)

    Sinha, Neeraj; Brinckman, Kevin; Jansen, Bernard; Seiner, John

    2011-01-01

    A method was developed of obtaining propulsive base flow data in both hot and cold jet environments, at Mach numbers and altitude of relevance to NASA launcher designs. The base flow data was used to perform computational fluid dynamics (CFD) turbulence model assessments of base flow predictive capabilities in order to provide increased confidence in base thermal and pressure load predictions obtained from computational modeling efforts. Predictive CFD analyses were used in the design of the experiments, available propulsive models were used to reduce program costs and increase success, and a wind tunnel facility was used. The data obtained allowed assessment of CFD/turbulence models in a complex flow environment, working within a building-block procedure to validation, where cold, non-reacting test data was first used for validation, followed by more complex reacting base flow validation.

  17. PALS (Passive Active L-band System) Radiometer-Based Soil Moisture Retrieval for the SMAP Validation Experiment 2012 (SMAPVEX12)

    NASA Astrophysics Data System (ADS)

    Colliander, A.; Jackson, T. J.; Chan, S.; Bindlish, R.; O'Neill, P. E.; Chazanoff, S. L.; McNairn, H.; Bullock, P.; Powers, J.; Wiseman, G.; Berg, A. A.; Magagi, R.; Njoku, E. G.

    2014-12-01

    NASA's (National Aeronautics and Space Administration) Soil Moisture Active Passive (SMAP) mission is scheduled for launch in early January 2015. For pre-launch soil moisture algorithm development and validation, the SMAP project and NASA coordinated a SMAP Validation Experiment 2012 (SMAPVEX12) together with Agriculture and Agri-Food Canada in the vicinity of Winnipeg, Canada in June 7-July 19, 2012. Coincident active and passive airborne L-band data were acquired using the Passive Active L-band System (PALS) on 17 days during the experiment. Simultaneously with the PALS measurements, soil moisture ground truth data were collected manually. The vegetation and surface roughness were sampled on non-flight days. The SMAP mission will produce surface (top 5 cm) soil moisture products a) using a combination of its L-band radiometer and SAR (Synthetic Aperture Radar) measurements, b) using the radiometer measurement only, and c) using the SAR measurements only. The SMAPVEX12 data are being utilized for the development and testing of the algorithms applied for generating these soil moisture products. This talk will focus on presenting results of retrieving surface soil moisture using the PALS radiometer. The issues that this retrieval faces are very similar to those faced by the global algorithm using the SMAP radiometer. However, the different spatial resolution of the two observations has to be accounted for in the analysis. The PALS 3 dB footprint in the experiment was on the order of 1 km, whereas the SMAP radiometer has a footprint of about 40 km. In this talk forward modeled brightness temperature over the manually sampled fields and the retrieved soil moisture over the entire experiment domain are presented and discussed. In order to provide a retrieval product similar to that of the SMAP passive algorithm, various ancillary information had to be obtained for the SMAPVEX12 domain. In many cases there are multiple options on how to choose and reprocess these data

  18. Honored Teacher Shows Commitment.

    ERIC Educational Resources Information Center

    Ratte, Kathy

    1987-01-01

    Part of the acceptance speech of the 1985 National Council for the Social Studies Teacher of the Year, this article describes the censorship experience of this honored social studies teacher. The incident involved the showing of a videotape version of the feature film entitled "The Seduction of Joe Tynan." (JDH)

  19. Development of a two-fluid drag law for clustered particles using direct numerical simulation and validation through experiments

    NASA Astrophysics Data System (ADS)

    Abbasi Baharanchi, Ahmadreza

    This dissertation focused on development and utilization of numerical and experimental approaches to improve the CFD modeling of fluidization flow of cohesive micron size particles. The specific objectives of this research were: (1) Developing a cluster prediction mechanism applicable to Two-Fluid Modeling (TFM) of gas-solid systems (2) Developing more accurate drag models for Two-Fluid Modeling (TFM) of gas-solid fluidization flow with the presence of cohesive interparticle forces (3) using the developed model to explore the improvement of accuracy of TFM in simulation of fluidization flow of cohesive powders (4) Understanding the causes and influential factor which led to improvements and quantification of improvements (5) Gathering data from a fast fluidization flow and use these data for benchmark validations. Simulation results with two developed cluster-aware drag models showed that cluster prediction could effectively influence the results in both the first and second cluster-aware models. It was proven that improvement of accuracy of TFM modeling using three versions of the first hybrid model was significant and the best improvements were obtained by using the smallest values of the switch parameter which led to capturing the smallest chances of cluster prediction. In the case of the second hybrid model, dependence of critical model parameter on only Reynolds number led to the fact that improvement of accuracy was significant only in dense section of the fluidized bed. This finding may suggest that a more sophisticated particle resolved DNS model, which can span wide range of solid volume fraction, can be used in the formulation of the cluster-aware drag model. The results of experiment suing high speed imaging indicated the presence of particle clusters in the fluidization flow of FCC inside the riser of FIU-CFB facility. In addition, pressure data was successfully captured along the fluidization column of the facility and used as benchmark validation data

  20. Downward shortwave surface irradiance from 17 sites for the FIRE/SRB Wisconsin experiment

    NASA Technical Reports Server (NTRS)

    Whitlock, Charles H.; Hay, John E.; Robinson, David A.; Cox, Stephen K.; Wardle, David I.; Lecroy, Stuart R.

    1990-01-01

    A field experiment was conducted in Wisconsin during Oct. to Nov. 1986 for purposes of both intensive cirrus cloud measurments and SRB algorithm validation activities. The cirrus cloud measurements were part of the FIRE. Tables are presented which show data from 17 sites in the First ISCCP (International Satellite Cloud Climatology Project) Regional Experiment/Surface Radiation Budget (FIRE/SRB) Wisconsin experiment region. A discussion of intercomparison results and calibration inconsistencies is also included.

  1. Observing System Simulation Experiments

    NASA Technical Reports Server (NTRS)

    Prive, Nikki

    2015-01-01

    This presentation gives an overview of Observing System Simulation Experiments (OSSEs). The components of an OSSE are described, along with discussion of the process for validating, calibrating, and performing experiments. a.

  2. Temperature field simulation and phantom validation of a Two-armed Spiral Antenna for microwave thermotherapy.

    PubMed

    Du, Yongxing; Zhang, Lingze; Sang, Lulu; Wu, Daocheng

    2016-04-29

    In this paper, an Archimedean planar spiral antenna for the application of thermotherapy was designed. This type of antenna was chosen for its compact structure, flexible application and wide heating area. The temperature field generated by the use of this Two-armed Spiral Antenna in a muscle-equivalent phantom was simulated and subsequently validated by experimentation. First, the specific absorption rate (SAR) of the field was calculated using the Finite Element Method (FEM) by Ansoft's High Frequency Structure Simulation (HFSS). Then, the temperature elevation in the phantom was simulated by an explicit finite difference approximation of the bioheat equation (BHE). The temperature distribution was then validated by a phantom heating experiment. The results showed that this antenna had a good heating ability and a wide heating area. A comparison between the calculation and the measurement showed a fair agreement in the temperature elevation. The validated model could be applied for the analysis of electromagnetic-temperature distribution in phantoms during the process of antenna design or thermotherapy experimentation.

  3. The Environmental Reward Observation Scale (EROS): development, validity, and reliability.

    PubMed

    Armento, Maria E A; Hopko, Derek R

    2007-06-01

    Researchers acknowledge a strong association between the frequency and duration of environmental reward and affective mood states, particularly in relation to the etiology, assessment, and treatment of depression. Given behavioral theories that outline environmental reward as a strong mediator of affect and the unavailability of an efficient, reliable, and valid self-report measure of environmental reward, we developed the Environmental Reward Observation Scale (EROS) and examined its psychometric properties. In Experiment 1, exploratory factor analysis supported a unidimensional 10-item measure with strong internal consistency and test-retest reliability. When administered to a replication sample, confirmatory factor analysis suggested an excellent fit to the 1-factor model and convergent/discriminant validity data supported the construct validity of the EROS. In Experiment 2, further support for the convergent validity of the EROS was obtained via moderate correlations with the Pleasant Events Schedule (PES; MacPhillamy & Lewinsohn, 1976). In Experiment 3, hierarchical regression supported the ecological validity of the EROS toward predicting daily diary reports of time spent in highly rewarding behaviors and activities. Above and beyond variance accounted for by depressive symptoms (BDI), the EROS was associated with significant incremental variance in accounting for time spent in both low and high reward behaviors. The EROS may represent a brief, reliable and valid measure of environmental reward that may improve the psychological assessment of negative mood states such as clinical depression.

  4. Towards natural language question generation for the validation of ontologies and mappings.

    PubMed

    Ben Abacha, Asma; Dos Reis, Julio Cesar; Mrabet, Yassine; Pruski, Cédric; Da Silveira, Marcos

    2016-08-08

    The increasing number of open-access ontologies and their key role in several applications such as decision-support systems highlight the importance of their validation. Human expertise is crucial for the validation of ontologies from a domain point-of-view. However, the growing number of ontologies and their fast evolution over time make manual validation challenging. We propose a novel semi-automatic approach based on the generation of natural language (NL) questions to support the validation of ontologies and their evolution. The proposed approach includes the automatic generation, factorization and ordering of NL questions from medical ontologies. The final validation and correction is performed by submitting these questions to domain experts and automatically analyzing their feedback. We also propose a second approach for the validation of mappings impacted by ontology changes. The method exploits the context of the changes to propose correction alternatives presented as Multiple Choice Questions. This research provides a question optimization strategy to maximize the validation of ontology entities with a reduced number of questions. We evaluate our approach for the validation of three medical ontologies. We also evaluate the feasibility and efficiency of our mappings validation approach in the context of ontology evolution. These experiments are performed with different versions of SNOMED-CT and ICD9. The obtained experimental results suggest the feasibility and adequacy of our approach to support the validation of interconnected and evolving ontologies. Results also suggest that taking into account RDFS and OWL entailment helps reducing the number of questions and validation time. The application of our approach to validate mapping evolution also shows the difficulty of adapting mapping evolution over time and highlights the importance of semi-automatic validation.

  5. Initial Validation of the Daily Spiritual Experiences Scale in Chinese Immigrants With Cancer Pain.

    PubMed

    Lo, Graciete; Chen, Jack; Wasser, Thomas; Portenoy, Russell; Dhingra, Lara

    2016-02-01

    Evaluating religious/spiritual influences in the growing Chinese-American population may inform the development of culturally relevant palliative care interventions. We assessed the psychometric properties and acceptability of the Daily Spiritual Experiences Scale-Chinese (DSES-C) in Chinese Americans with cancer-related pain. The translated 16-item DSES-C was administered as part of a symptom intervention for Chinese-American cancer patients. Patients were recruited from four New York community oncology practices. Of 321 patients, 78.7% were born in Mainland China, 79.1% spoke Cantonese, and 70.2% endorsed a religious affiliation (Ancestor worship, 31.7%; Chinese God worship, 29.8%; Buddhism, 17.1%; Christianity, 14.0%). In total, 82.6% completed the DSES-C (mean age = 57.7 years; 60.8% women) and 17.4% declined (mean age = 59.3 years; 52.0% women). Reasons for declining included low religiosity or perceived relevance of the scale items and difficulties separating spirituality from religiosity terms. Individuals having a religious affiliation were more likely to complete the DSES-C, whereas those not engaging in individual spiritual/religious practices or frequent group spiritual/religious practices tended to decline (all P < 0.05). The DSES-C (mean total score = 43.6, SD = 19.3) demonstrated high reliability (alpha = 0.94). Exploratory factor analysis suggested a one-factor solution, with significant loadings (>0.40) across items except Item 14 ("Accept others"). Construct validity was suggested by a positive association between DSES-C scores and having a religious affiliation (P < 0.05). In Chinese Americans with cancer pain, the DSES-C demonstrated acceptable psychometrics. Some participants experienced linguistic or cultural barriers preventing completion. Future investigations should provide additional validation in different Asian subgroups and those with varied medical conditions. Copyright © 2016 American Academy of Hospice and Palliative Medicine. All

  6. Hovering Dual-Spin Vehicle Groundwork for Bias Momentum Sizing Validation Experiment

    NASA Technical Reports Server (NTRS)

    Rothhaar, Paul M.; Moerder, Daniel D.; Lim, Kyong B.

    2008-01-01

    Angular bias momentum offers significant stability augmentation for hovering flight vehicles. The reliance of the vehicle on thrust vectoring for agility and disturbance rejection is greatly reduced with significant levels of stored angular momentum in the system. A methodical procedure for bias momentum sizing has been developed in previous studies. This current study provides groundwork for experimental validation of that method using an experimental vehicle called the Dual-Spin Test Device, a thrust-levitated platform. Using measured data the vehicle's thrust vectoring units are modeled and a gust environment is designed and characterized. Control design is discussed. Preliminary experimental results of the vehicle constrained to three rotational degrees of freedom are compared to simulation for a case containing no bias momentum to validate the simulation. A simulation of a bias momentum dominant case is presented.

  7. ER-2 #809 on the SAGE III Ozone Loss and Validation Experiment (SOLVE) with pilot Dee Porter prepari

    NASA Technical Reports Server (NTRS)

    2000-01-01

    Lockheed Martin pilot Dee Porter climbs up the ladder wearing a heavy tan pressure suit, preparing to board NASA ER-2 #809 at Kiruna, Sweden, for the third flight in the SAGE III Ozone Loss and Validation Experiment. Assisting him is Jim Sokolik, a Lockheed Martin life support technician. Number 809, one of Dryden's two high-flying ER-2 Airborne Science aircraft, a civilian variant of Lockheed's U-2, and another NASA flying laboratory, Dryden's DC-8, were based north of the Arctic Circle in Kiruna, Sweden during the winter of 2000 to study ozone depletion as part of the SAGE III Ozone Loss and Validation Experiment (SOLVE). A large hangar built especially for research, 'Arena Arctica' housed the instrumented aircraft and the scientists. Scientists have observed unusually low levels of ozone over the Arctic during recent winters, raising concerns that ozone depletion there could become more widespread as in the Antarctic ozone hole. The NASA-sponsored international mission took place between November 1999 and March 2000 and was divided into three phases. The DC-8 was involved in all three phases returning to Dryden between each phase. The ER-2 flew sample collection flights between January and March, remaining in Sweden from Jan. 9 through March 16. 'The collaborative campaign will provide an immense new body of information about the Arctic stratosphere,' said program scientist Dr. Michael Kurylo, NASA Headquarters. 'Our understanding of the Earth's ozone will be greatly enhanced by this research.' ER-2s bearing tail numbers 806 and 809 are used as airborne science platforms by NASA's Dryden Flight Research Center. The aircraft are platforms for a variety of high-altitude science missions flown over various parts of the world. They are also used for earth science and atmospheric sensor research and development, satellite calibration and data validation. The ER-2s are capable of carrying a maximum payload of 2,600 pounds of experiments in a nose bay, the main

  8. Three-dimensional fuel pin model validation by prediction of hydrogen distribution in cladding and comparison with experiment

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Aly, A.; Avramova, Maria; Ivanov, Kostadin

    To correctly describe and predict this hydrogen distribution there is a need for multi-physics coupling to provide accurate three-dimensional azimuthal, radial, and axial temperature distributions in the cladding. Coupled high-fidelity reactor-physics codes with a sub-channel code as well as with a computational fluid dynamics (CFD) tool have been used to calculate detailed temperature distributions. These high-fidelity coupled neutronics/thermal-hydraulics code systems are coupled further with the fuel-performance BISON code with a kernel (module) for hydrogen. Both hydrogen migration and precipitation/dissolution are included in the model. Results from this multi-physics analysis is validated utilizing calculations of hydrogen distribution using models informed bymore » data from hydrogen experiments and PIE data.« less

  9. The comparison of BRDF model and validation of MCD43 products by the 2013 Dunhuang Gobi experiments

    NASA Astrophysics Data System (ADS)

    Li, Yuan; Rong, Zhi-guo; Zhang, Li-jun; Sun, Ling; Xu, Na

    2014-11-01

    BRDF has numerous applications in on-orbit satellites vicarious calibration. The 2013 Dunhuang Gobi surface directional reflectance measurements experiment were held during Aug. 20 to Aug. 28. In order to match the spatial resolution (0.25-1.25km) of meteorological satellites, 3*3 sample points were selected covering the 10*10km area. All the data were measured during (3 hours before and after) the noon without taking into account the large sun zenith angle because of the lack of the satellite passing through. Totally 9 groups of directional reflectance (DREF) were measured by the use of ASD (350-2500nm), standard reference board and a portable DREF measurement system. At each point, DREF were measured by different observation zenith angle (0, 20, 40 and 60 degree) and azimuth angle (0, 45, 90, 135, 180, 225, 270, 315 and 360 degree) in 30 minutes. Different BRDF models were selected such as Walthall, Sine Walthall, Hapke, Roujean and Ross-Li. The model coefficients were derived corresponding to the observed data. The relative differences (RD) of the models with respect to the measured values were calculated. The accuracy of MCD43 products in the Julian day of 233 and 241 were also validated. Results showed that Ross-Li model had the smallest RD. The RD between the DREF from MCD43 products and the measured values were 10.26%(233) and 8.96% (241)@550nm, respectively.

  10. Numerical experiment to estimate the validity of negative ion diagnostic using photo-detachment combined with Langmuir probing

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Oudini, N.; Sirse, N.; Ellingboe, A. R.

    2015-07-15

    This paper presents a critical assessment of the theory of photo-detachment diagnostic method used to probe the negative ion density and electronegativity α = n{sub -}/n{sub e}. In this method, a laser pulse is used to photo-detach all negative ions located within the electropositive channel (laser spot region). The negative ion density is estimated based on the assumption that the increase of the current collected by an electrostatic probe biased positively to the plasma is a result of only the creation of photo-detached electrons. In parallel, the background electron density and temperature are considered as constants during this diagnostics. While the numericalmore » experiments performed here show that the background electron density and temperature increase due to the formation of an electrostatic potential barrier around the electropositive channel. The time scale of potential barrier rise is about 2 ns, which is comparable to the time required to completely photo-detach the negative ions in the electropositive channel (∼3 ns). We find that neglecting the effect of the potential barrier on the background plasma leads to an erroneous determination of the negative ion density. Moreover, the background electron velocity distribution function within the electropositive channel is not Maxwellian. This is due to the acceleration of these electrons through the electrostatic potential barrier. In this work, the validity of the photo-detachment diagnostic assumptions is questioned and our results illustrate the weakness of these assumptions.« less

  11. Retrieval and validation of carbon dioxide, methane and water vapor for the Canary Islands IR-laser occultation experiment

    NASA Astrophysics Data System (ADS)

    Proschek, V.; Kirchengast, G.; Schweitzer, S.; Brooke, J. S. A.; Bernath, P. F.; Thomas, C. B.; Wang, J.-G.; Tereszchuk, K. A.; González Abad, G.; Hargreaves, R. J.; Beale, C. A.; Harrison, J. J.; Martin, P. A.; Kasyutich, V. L.; Gerbig, C.; Kolle, O.; Loescher, A.

    2014-11-01

    The first ground-based experiment to prove the concept of a novel space-based observation technique for microwave and infrared-laser occultation between Low Earth Orbit satellites (LMIO) was performed in the Canary Islands between La Palma and Tenerife in July 2011. This experiment aimed to demonstrate the infrared-laser differential transmission principle for the measurement of greenhouse gases (GHGs) in the free atmosphere. Such global and long-term stable measurements of GHGs, accompanied also by measurements of thermodynamic parameters and line-of-sight wind in a self-calibrating way, have become very important for climate change monitoring. The experiment delivered promising initial data for demonstrating the new observation concept by retrieving volume mixing ratios of GHGs along a ~ 144 km signal path at altitudes of ~ 2.4 km. Here, we present a detailed analysis of the measurements, following a recent publication that introduced the experiment's technical setup and first results for an example retrieval of CO2. We present the observational and validation datasets, the latter simultaneously measured at the transmitter and receiver sites, the measurement data handling, and the differential transmission retrieval procedure. We also determine the individual and combined uncertainties influencing the results and present the retrieval results for 12CO2, 13CO2, C18OO, H2O and CH4. The new method is found to have a reliable basis for monitoring of greenhouse gases such as CO2, CH4, and H2O in the free atmosphere.

  12. Exploring validation of a graphic symbol questionnaire to measure participation experiences of youth in activity settings.

    PubMed

    Batorowicz, Beata; King, Gillian; Vane, Freda; Pinto, Madhu; Raghavendra, Parimala

    2017-06-01

    Participation has a subjective and private dimension, and so it is important to hear directly from youth about their experiences in various activity settings, the places where they "do things" and interact with others. To meet this need, our team developed the Self-Reported Experiences of Activity Settings (SEAS) measure, which demonstrated good-to-excellent measurement properties. To address the needs of youth who could benefit from graphic symbol support, the SEAS-PCS TM , 1 was created. The purpose of this paper is to describe the development of SEAS-PCS and the preliminary study that explores the equivalency of the SEAS and SEAS-PCS. The SEAS and SEAS-PCS were compared in terms of the equivalency of meaning of stimulus items by 11 professionals and five adults who used augmentative and alternative communication, were familiar with PCS, and were fluent readers. Out of 22 items, 68% were rated as highly similar on a 5-point scale (M = 4.14; SD = .70; mdn = 4; range: 2.81-5.00). Subsequently, the 32% of the SEAS-PCS items that were rated below 4 were modified based on the participants' specific comments. Further work is required to validate the SEAS-PCS. The next step could involve exploring the views of youth who use AAC.

  13. Software reliability: Additional investigations into modeling with replicated experiments

    NASA Technical Reports Server (NTRS)

    Nagel, P. M.; Schotz, F. M.; Skirvan, J. A.

    1984-01-01

    The effects of programmer experience level, different program usage distributions, and programming languages are explored. All these factors affect performance, and some tentative relational hypotheses are presented. An analytic framework for replicated and non-replicated (traditional) software experiments is presented. A method of obtaining an upper bound on the error rate of the next error is proposed. The method was validated empirically by comparing forecasts with actual data. In all 14 cases the bound exceeded the observed parameter, albeit somewhat conservatively. Two other forecasting methods are proposed and compared to observed results. Although demonstrated relative to this framework that stages are neither independent nor exponentially distributed, empirical estimates show that the exponential assumption is nearly valid for all but the extreme tails of the distribution. Except for the dependence in the stage probabilities, Cox's model approximates to a degree what is being observed.

  14. [Validity and Reliability of Korean Version of the Spiritual Care Competence Scale].

    PubMed

    Chung, Mi Ja; Park, Youngrye; Eun, Young

    2016-12-01

    The aim of this study was to examine the validity and reliability of the Korean Version of the Spiritual Care Competence Scale (K-SCCS). A cross-sectional study design was used. The K-SCCS consisted of 26 questions to measure spiritual care competence of nurses. Participants, 228 nurses who had more than 3 years'experience as a nurse, completed the survey. Confirmatory factor analysis was used to examine the construct validity and correlations of K-SCCS and spiritual well-being (SWB) were used to examine the criterion validity of K-SCCS. Cronbach's alpha was used to test internal consistency. The construct and the criterion-related validity of K-SCCS were supported as measures of spiritual care competence. Cronbach's alpha was .95. Factor loadings of the 26 questions ranged from .60 to .96. Construct validity of K-SCCS was verified by confirmatory factor analysis (RMSEA=.08, CFI=.90, NFI=.85). Criterion validity compared to the SWB showed significant correlation (r=.44, p<.001). The findings suggest that K-SCCS serves as an appropriate measure of spiritual care competence with validity and reliability. However, further study is needed to retest the verification of the factor analysis related to factor 2 (professionalisation and improving the quality of spiritual care) and factor 3 (personal support and patient counseling). Therefore, we recommend using the total score without distinguishing subscales.

  15. Design and validation of a method for evaluation of interocular interaction.

    PubMed

    Lai, Xin Jie Angela; Alexander, Jack; Ho, Arthur; Yang, Zhikuan; He, Mingguang; Suttle, Catherine

    2012-02-01

    To design a simple viewing system allowing dichoptic masking, and to validate this system in adults and children with normal vision. A Trial Frame Apparatus (TFA) was designed to evaluate interocular interaction. This device consists of a trial frame, a 1 mm pinhole in front of the tested eye and a full or partial occluder in front of the non-tested eye. The difference in visual function in one eye between the full- and partial-occlusion conditions was termed the Interaction Index. In experiment 1, low-contrast acuity was measured in six adults using five types of partial occluder. Interaction Index was compared between these five, and the occluder showing the highest Index was used in experiment 2. In experiment 2, low-contrast acuity, contrast sensitivity, and alignment sensitivity were measured in the non-dominant eye of 45 subjects (15 older adults, 15 young adults, and 15 children), using the TFA and an existing well-validated device (shutter goggles) with full and partial occlusion of the dominant eye. These measurements were repeated on 11 subjects of each group using TFA in the partial-occlusion condition only. Repeatability of visual function measurements using TFA was assessed using the Bland-Altman method and agreement between TFA and goggles in terms of visual functions and interactions was assessed using the Bland-Altman method and t-test. In all three subject groups, the TFA showed a high level of repeatability in all visual function measurements. Contrast sensitivity was significantly poorer when measured using TFA than using goggles (p < 0.05). However, Interaction Index of all three visual functions showed acceptable agreement between TFA and goggles (p > 0.05). The TFA may provide an acceptable method for the study of some forms of dichoptic masking in populations where more complex devices (e.g., shutter goggles) cannot be used.

  16. Use of the FDA nozzle model to illustrate validation techniques in computational fluid dynamics (CFD) simulations

    PubMed Central

    Hariharan, Prasanna; D’Souza, Gavin A.; Horner, Marc; Morrison, Tina M.; Malinauskas, Richard A.; Myers, Matthew R.

    2017-01-01

    A “credible” computational fluid dynamics (CFD) model has the potential to provide a meaningful evaluation of safety in medical devices. One major challenge in establishing “model credibility” is to determine the required degree of similarity between the model and experimental results for the model to be considered sufficiently validated. This study proposes a “threshold-based” validation approach that provides a well-defined acceptance criteria, which is a function of how close the simulation and experimental results are to the safety threshold, for establishing the model validity. The validation criteria developed following the threshold approach is not only a function of Comparison Error, E (which is the difference between experiments and simulations) but also takes in to account the risk to patient safety because of E. The method is applicable for scenarios in which a safety threshold can be clearly defined (e.g., the viscous shear-stress threshold for hemolysis in blood contacting devices). The applicability of the new validation approach was tested on the FDA nozzle geometry. The context of use (COU) was to evaluate if the instantaneous viscous shear stress in the nozzle geometry at Reynolds numbers (Re) of 3500 and 6500 was below the commonly accepted threshold for hemolysis. The CFD results (“S”) of velocity and viscous shear stress were compared with inter-laboratory experimental measurements (“D”). The uncertainties in the CFD and experimental results due to input parameter uncertainties were quantified following the ASME V&V 20 standard. The CFD models for both Re = 3500 and 6500 could not be sufficiently validated by performing a direct comparison between CFD and experimental results using the Student’s t-test. However, following the threshold-based approach, a Student’s t-test comparing |S-D| and |Threshold-S| showed that relative to the threshold, the CFD and experimental datasets for Re = 3500 were statistically similar and

  17. Validation of the Neonatal Satisfaction Survey (NSS-8) in six Norwegian neonatal intensive care units: a quantitative cross-sectional study.

    PubMed

    Hagen, Inger Hilde; Svindseth, Marit Følsvik; Nesset, Erik; Orner, Roderick; Iversen, Valentina Cabral

    2018-03-27

    The experience of having their new-borns admitted to an intensive care unit (NICU) can be extremely distressing. Subsequent risk of post-incident-adjustment difficulties are increased for parents, siblings, and affected families. Patient and next of kin satisfaction surveys provide key indicators of quality in health care. Methodically constructed and validated survey tools are in short supply and parents' experiences of care in Neonatal Intensive Care Units is under-researched. This paper reports a validation of the Neonatal Satisfaction Survey (NSS-8) in six Norwegian NICUs. Parents' survey returns were collected using the Neonatal Satisfaction Survey (NSS-13). Data quality and psychometric properties were systematically assessed using exploratory factor analysis, tests of internal consistency, reliability, construct, convergent and discriminant validity. Each set of hospital returns were subjected to an apostasy analysis before an overall satisfaction rate was calculated. The survey sample of 568 parents represents 45% of total eligible population for the period of the study. Missing data accounted for 1,1% of all returns. Attrition analysis shows congruence between sample and total population. Exploratory factor analysis identified eight factors of concern to parents,"Care and Treatment", "Doctors", "Visits", "Information", "Facilities", "Parents' Anxiety", "Discharge" and "Sibling Visits". All factors showed satisfactory internal consistency, good reliability (Cronbach's alpha ranged from 0.70-0.94). For the whole scale of 51 items α 0.95. Convergent validity using Spearman's rank between the eight factors and question measuring overall satisfaction was significant on all factors. Discriminant validity was established for all factors. Overall satisfaction rates ranged from 86 to 90% while for each of the eight factors measures of satisfaction varied between 64 and 86%. The NSS-8 questionnaire is a valid and reliable scale for measuring parents' assessment of

  18. The Challenging Experience Questionnaire: Characterization of challenging experiences with psilocybin mushrooms.

    PubMed

    Barrett, Frederick S; Bradstreet, Matthew P; Leoutsakos, Jeannie-Marie S; Johnson, Matthew W; Griffiths, Roland R

    2016-12-01

    Acute adverse psychological reactions to classic hallucinogens ("bad trips" or "challenging experiences"), while usually benign with proper screening, preparation, and support in controlled settings, remain a safety concern in uncontrolled settings (such as illicit use contexts). Anecdotal and case reports suggest potential adverse acute symptoms including affective (panic, depressed mood), cognitive (confusion, feelings of losing sanity), and somatic (nausea, heart palpitation) symptoms. Responses to items from several hallucinogen-sensitive questionnaires (Hallucinogen Rating Scale, the States of Consciousness Questionnaire, and the Five-Dimensional Altered States of Consciousness questionnaire) in an Internet survey of challenging experiences with the classic hallucinogen psilocybin were used to construct and validate a Challenging Experience Questionnaire. The stand-alone Challenging Experience Questionnaire was then validated in a separate sample. Seven Challenging Experience Questionnaire factors (grief, fear, death, insanity, isolation, physical distress, and paranoia) provide a phenomenological profile of challenging aspects of experiences with psilocybin. Factor scores were associated with difficulty, meaningfulness, spiritual significance, and change in well-being attributed to the challenging experiences. The factor structure did not differ based on gender or prior struggle with anxiety or depression. The Challenging Experience Questionnaire provides a basis for future investigation of predictors and outcomes of challenging experiences with classic hallucinogens. © The Author(s) 2016.

  19. Integration and Validation of Hysteroscopy Simulation in the Surgical Training Curriculum.

    PubMed

    Elessawy, Mohamed; Skrzipczyk, Moritz; Eckmann-Scholz, Christel; Maass, Nicolai; Mettler, Liselotte; Guenther, Veronika; van Mackelenbergh, Marion; Bauerschlag, Dirk O; Alkatout, Ibrahim

    ergonomics, the novices showed a better pretest value than the experts; however, the experts were able to improve significantly during the posttest. These precise findings demonstrated that the multimetric scoring system achieved several important objectives, including clinical relevance, critical relevance, and training motivation. All participants demonstrated improvements in their hysteroscopic skills, proving an adequate construct validation of the HystSim. Using the multimetric scoring system enabled a more accurate analysis of the performance of the participants independent of their levels of experience which could be an important key for streamlining the learning curve. Future studies testing the predictive validation of the simulator and frequency of the training intervals are necessary before the introduction of the simulator into the standard surgical training curriculum. Copyright © 2016 Association of Program Directors in Surgery. Published by Elsevier Inc. All rights reserved.

  20. Validation of a δ2Hn-alkane-δ18Ohemicellulose based paleohygrometer: Implications from a climate chamber experiment

    NASA Astrophysics Data System (ADS)

    Hepp, Johannes; Kathrin Schäfer, Imke; Tuthorn, Mario; Wüthrich, Lorenz; Zech, Jana; Glaser, Bruno; Juchelka, Dieter; Rozanski, Kazimierz; Zech, Roland; Mayr, Christoph; Zech, Michael

    2017-04-01

    Leaf wax-derived biomarkers, e.g. long chain n-alkanes and fatty acids, and their hydrogen isotopic composition are proved to be of a value in paleoclimatology/-hydrology research. However, the alteration of the isotopic signal as a result of the often unknown amount of leaf water enrichment challenges a direct reconstruction of the isotopic composition of paleoprecipitation. The coupling of ^2H/^1H results of leaf wax-derived biomarkers with 18O/16O results of hemicellulose-derived sugars has the potential to overcome this limitation and additionally allows reconstructing relative air humidity (RH) (Zech et al., 2013). This approach was recently validated by Tuthorn et al. (2015) by applying it to topsoil samples along a climate transect in Argentina. Accordingly, the biomarker-derived RH values correlate significantly with modern actual RH values from the respective study sites, showing the potential of the established 'paleohygrometer' approach. However, a climate chamber validation study to answer open questions regarding this approach, e.g. how robust biosynthetic fractionation factors are, is still missing. Here we present coupled δ2Hn-alkane-δ18Ohemicellulose results obtained for leaf material from a climate chamber experiment, in which Eucalyptus globulus, Vicia faba and Brassica oleracea were grown under controlled conditions (Mayr, 2003). First, the 2H and 18O enrichment of leaf water strongly reflects actual RH values of the climate chambers. Second, the biomarker-based reconstructed RH values correlate well with the actual RH values of the respective climate chamber, validating the proposed 'paleohygrometer' approach. And third, the calculated fractionation factors between the investigated leaf biomarkers (n-C29 and n-C31 for alkanes; arabinose and xylose for hemicellulose) and leaf water are close to the expected once reviewed from the literature (+27\\permil for hemicellulose; -155\\permil for n-alkanes). Nevertheless, minor dependencies of these

  1. Validating solar and solar-like star opacities

    NASA Astrophysics Data System (ADS)

    Le Pennec, Maëlle; TURCK-CHIEZE, Sylvaine; RIBEYRE, Xavier; DUCRET, Jean-Eric; BLANCARD, Christophe; COSSE, Philippe; MONDET, Guillaume; FAUSSURIER, Gérald

    2015-08-01

    The Sun is, as being our closest star, a privilege place to test and validate physics. However, the solar physics is not yet completely understood. Indeed, since the recent update of the solar composition, there are differences between solar models and seismic data, visible on the solar sound speed profile comparison. This well established large discrepancy (Turck-Chièze et al. 2001, 2004, 2011, Christensen-Dalsgaard et al. 2009, Basu et al. 2015) could be linked to radiative transfer issue.Two directions of investigation are proposed. One possibility to explain this gap could be that the Sun produces slightly more energy that it liberates on its surface (around 5%). This energy could be transformed into macroscopic motions in the radiative zone, which are not taken into account in the solar standard model. Another explanation could be that the calculations of energy transport are not correctly taken into account either on the calculation of the Rosseland mean values or in the treatment of the radiative acceleration. This could have an impact on the determination of the internal solar abundances.Unfortunately, there are very few experiments to validate these calculations (Bailey et al. 2014). That's why we are proposing an opacity experiment on a high-energy laser like LMJ, in the conditions of the radiative zone (T=[2 - 15.106 K] and ρ=[0.2 - 150 g/cm3]). The aim is to measure the opacity of the most important contributors to the global opacity in this solar area : iron, oxygen and silicon. We are exploiting in that purpose a technical approach called the Double Ablation Front. During the laser-plasma interaction, the plasma radiative effects allow to reach these high temperatures and densities at LTE and validate or not plasma effects and line widths. We will show the principle of this technique and the results of our simulations on several elements.In the mean time, we are also exploiting new opacity calculations thanks to the OPAS code (Blancard et al. 2012

  2. Validation of the urostomy education scale: the European experience.

    PubMed

    Jensen, Bente Thoft; de Blok, W; Kiesbye, Berit; Kristensen, Susanne A

    2013-01-01

    Bladder cancer is the fourth most common cancer among European males. Once diagnosed with muscle invasive bladder cancer, a radical cystectomy is the first line treatment, which results in a urostomy. The placement of a urostomy and the care required impacts the patient's life. Previous research validated the Urostomy Education Scale as the first standardized tool capable of documenting the patients' level of stoma self-care skills and useful to guide patient education interventions. A Danish-Dutch Fellowship was established to support and provide further evidence of applicability of the Urostomy Education Scale.

  3. Evaluation and implementation of chemotherapy regimen validation in an electronic health record.

    PubMed

    Diaz, Amber H; Bubalo, Joseph S

    2014-12-01

    Computerized provider order entry of chemotherapy regimens is quickly becoming the standard for prescribing chemotherapy in both inpatient and ambulatory settings. One of the difficulties with implementation of chemotherapy regimen computerized provider order entry lies in verifying the accuracy and completeness of all regimens built in the system library. Our goal was to develop, implement, and evaluate a process for validating chemotherapy regimens in an electronic health record. We describe our experience developing and implementing a process for validating chemotherapy regimens in the setting of a standard, commercially available computerized provider order entry system. The pilot project focused on validating chemotherapy regimens in the adult inpatient oncology setting and adult ambulatory hematologic malignancy setting. A chemotherapy regimen validation process was defined as a result of the pilot project. Over a 27-week pilot period, 32 chemotherapy regimens were validated using the process we developed. Results of the study suggest that by validating chemotherapy regimens, the amount of time spent by pharmacists in daily chemotherapy review was decreased. In addition, the number of pharmacist modifications required to make regimens complete and accurate were decreased. Both physician and pharmacy disciplines showed improved satisfaction and confidence levels with chemotherapy regimens after implementation of the validation system. Chemotherapy regimen validation required a considerable amount of planning and time but resulted in increased pharmacist efficiency and improved provider confidence and satisfaction. © The Author(s) 2014 Reprints and permissions: sagepub.co.uk/journalsPermissions.nav.

  4. WEC-SIM Phase 1 Validation Testing -- Numerical Modeling of Experiments: Preprint

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Ruehl, Kelley; Michelen, Carlos; Bosma, Bret

    2016-08-01

    The Wave Energy Converter Simulator (WEC-Sim) is an open-source code jointly developed by Sandia National Laboratories and the National Renewable Energy Laboratory. It is used to model wave energy converters subjected to operational and extreme waves. In order for the WEC-Sim code to be beneficial to the wave energy community, code verification and physical model validation is necessary. This paper describes numerical modeling of the wave tank testing for the 1:33-scale experimental testing of the floating oscillating surge wave energy converter. The comparison between WEC-Sim and the Phase 1 experimental data set serves as code validation. This paper is amore » follow-up to the WEC-Sim paper on experimental testing, and describes the WEC-Sim numerical simulations for the floating oscillating surge wave energy converter.« less

  5. Evaluating the experiences and support needs of people living with chronic cancer: development and initial validation of the Chronic Cancer Experiences Questionnaire (CCEQ).

    PubMed

    Harley, Clare; Pini, Simon; Kenyon, Lucille; Daffu-O'Reilly, Amrit; Velikova, Galina

    2016-08-10

    Many advanced cancers are managed as chronic diseases, yet there are currently no international guidelines for the support of patients living with chronic cancer. It is important to understand whether care and service arrangements meet the needs of this rapidly growing patient group. This study aimed to develop and validate a questionnaire to capture patients' experiences of living with chronic cancer and their views of clinical and support services. The research was carried out between 1 July 2010 and 21 February 2013. A conceptual framework and initial item bank were derived from prior interviews with 56 patients with chronic cancer. Items were reviewed by 4 oncologists and 1 clinical nurse specialist and during 2 focus groups with 9 patients. Pilot questionnaires were completed by 416 patients across 5 cancer units. Item selection and scale reliability was explored using descriptive data, exploratory factor analysis, internal consistency analyses, multitrait scaling analyses and known-groups comparisons. The final Chronic Cancer Experiences Questionnaire (CCEQ) includes 75 items. 62 items contribute to 14 subscales with internal consistency between α 0·68-0·88 and minimal scaling errors. Known-groups comparisons confirmed subscale utility in distinguishing between patient groups. Subscales were labelled: managing appointments, coordination of care, general practitioner involvement, clinical trials, information and questions, making treatment decisions, symptom non-reporting, key worker, limitations, sustaining normality, financial advice, worries and anxieties, sharing feelings with others, and accessing support. 13 items assessing symptom experiences were retained as single items. The CCEQ has the potential to be used as a clinical instrument to assess patient experiences of chronic cancer or to screen for patient needs. It may also be used as an outcome measure for evaluating programmes and models of care and may identify areas for service development that

  6. Further Validation of the IDAS: Evidence of Convergent, Discriminant, Criterion, and Incremental Validity

    ERIC Educational Resources Information Center

    Watson, David; O'Hara, Michael W.; Chmielewski, Michael; McDade-Montez, Elizabeth A.; Koffel, Erin; Naragon, Kristin; Stuart, Scott

    2008-01-01

    The authors explicated the validity of the Inventory of Depression and Anxiety Symptoms (IDAS; D. Watson et al., 2007) in 2 samples (306 college students and 605 psychiatric patients). The IDAS scales showed strong convergent validity in relation to parallel interview-based scores on the Clinician Rating version of the IDAS; the mean convergent…

  7. Intoxication-Related Alcohol Mixed with Energy Drink Expectancies Scale: Initial Development and Validation.

    PubMed

    Miller, Kathleen E; Dermen, Kurt H; Lucke, Joseph F

    2017-06-01

    Young adult use of alcohol mixed with energy drinks (AmEDs) has been linked with elevated risks of a constellation of problem behaviors. These risks may be conditioned by expectancies regarding the effects of caffeine in conjunction with alcohol consumption. The aim of this study was to describe the construction and psychometric evaluation of the Intoxication-Related AmED Expectancies Scale (AmED_EXPI), 15 self-report items measuring beliefs about how the experience of AmED intoxication differs from the experience of noncaffeinated alcohol (NCA) intoxication. Scale development and testing were conducted using data from a U.S. national sample of 3,105 adolescents and emerging adults aged 13 to 25. Exploratory and confirmatory factor analyses were conducted to evaluate the factor structure and establish factor invariance across gender, age, and prior experience with AmED use. Cross-sectional and longitudinal analyses examining correlates of AmED use were used to assess construct and predictive validity. In confirmatory factor analyses, fit indices for the hypothesized 4-factor structure (i.e., Intoxication Management [IM], Alertness [AL], Sociability [SO], and Jitters [JT]) revealed a moderately good fit to the data. Together, these factors accounted for 75.3% of total variance. The factor structure was stable across male/female, teen/young adult, and AmED experience/no experience subgroups. The resultant unit-weighted subscales showed strong internal consistency and satisfactory convergent validity. Baseline scores on the IM, SO, and JT subscales predicted changes in AmED use over a subsequent 3-month period. The AmED_EXPI appears to be a reliable and valid tool for measuring expectancies about the effects of caffeine during alcohol intoxication. Copyright © 2017 by the Research Society on Alcoholism.

  8. Cross Validation Through Two-Dimensional Solution Surface for Cost-Sensitive SVM.

    PubMed

    Gu, Bin; Sheng, Victor S; Tay, Keng Yeow; Romano, Walter; Li, Shuo

    2017-06-01

    Model selection plays an important role in cost-sensitive SVM (CS-SVM). It has been proven that the global minimum cross validation (CV) error can be efficiently computed based on the solution path for one parameter learning problems. However, it is a challenge to obtain the global minimum CV error for CS-SVM based on one-dimensional solution path and traditional grid search, because CS-SVM is with two regularization parameters. In this paper, we propose a solution and error surfaces based CV approach (CV-SES). More specifically, we first compute a two-dimensional solution surface for CS-SVM based on a bi-parameter space partition algorithm, which can fit solutions of CS-SVM for all values of both regularization parameters. Then, we compute a two-dimensional validation error surface for each CV fold, which can fit validation errors of CS-SVM for all values of both regularization parameters. Finally, we obtain the CV error surface by superposing K validation error surfaces, which can find the global minimum CV error of CS-SVM. Experiments are conducted on seven datasets for cost sensitive learning and on four datasets for imbalanced learning. Experimental results not only show that our proposed CV-SES has a better generalization ability than CS-SVM with various hybrids between grid search and solution path methods, and than recent proposed cost-sensitive hinge loss SVM with three-dimensional grid search, but also show that CV-SES uses less running time.

  9. Toward Supersonic Retropropulsion CFD Validation

    NASA Technical Reports Server (NTRS)

    Kleb, Bil; Schauerhamer, D. Guy; Trumble, Kerry; Sozer, Emre; Barnhardt, Michael; Carlson, Jan-Renee; Edquist, Karl

    2011-01-01

    This paper begins the process of verifying and validating computational fluid dynamics (CFD) codes for supersonic retropropulsive flows. Four CFD codes (DPLR, FUN3D, OVERFLOW, and US3D) are used to perform various numerical and physical modeling studies toward the goal of comparing predictions with a wind tunnel experiment specifically designed to support CFD validation. Numerical studies run the gamut in rigor from code-to-code comparisons to observed order-of-accuracy tests. Results indicate that this complex flowfield, involving time-dependent shocks and vortex shedding, design order of accuracy is not clearly evident. Also explored is the extent of physical modeling necessary to predict the salient flowfield features found in high-speed Schlieren images and surface pressure measurements taken during the validation experiment. Physical modeling studies include geometric items such as wind tunnel wall and sting mount interference, as well as turbulence modeling that ranges from a RANS (Reynolds-Averaged Navier-Stokes) 2-equation model to DES (Detached Eddy Simulation) models. These studies indicate that tunnel wall interference is minimal for the cases investigated; model mounting hardware effects are confined to the aft end of the model; and sparse grid resolution and turbulence modeling can damp or entirely dissipate the unsteadiness of this self-excited flow.

  10. Validation of a dye stain assay for vaginally inserted HEC-filled microbicide applicators

    PubMed Central

    Katzen, Lauren L.; Fernández-Romero, José A.; Sarna, Avina; Murugavel, Kailapuri G.; Gawarecki, Daniel; Zydowsky, Thomas M.; Mensch, Barbara S.

    2011-01-01

    Background The reliability and validity of self-reports of vaginal microbicide use are questionable given the explicit understanding that participants are expected to comply with study protocols. Our objective was to optimize the Population Council's previously validated dye stain assay (DSA) and related procedures, and establish predictive values for the DSA's ability to identify vaginally inserted single-use, low-density polyethylene microbicide applicators filled with hydroxyethylcellulose gel. Methods Applicators, inserted by 252 female sex workers enrolled in a microbicide feasibility study in Southern India, served as positive controls for optimization and validation experiments. Prior to validation, optimal dye concentration and staining time were ascertained. Three validation experiments were conducted to determine sensitivity, specificity, negative predictive values and positive predictive values. Results The dye concentration of 0.05% (w/v) FD&C Blue No. 1 Granular Food Dye and staining time of five seconds were determined to be optimal and were used for the three validation experiments. There were a total of 1,848 possible applicator readings across validation experiments; 1,703 (92.2%) applicator readings were correct. On average, the DSA performed with 90.6% sensitivity, 93.9% specificity, and had a negative predictive value of 93.8% and a positive predictive value of 91.0%. No statistically significant differences between experiments were noted. Conclusions The DSA was optimized and successfully validated for use with single-use, low-density polyethylene applicators filled with hydroxyethylcellulose (HEC) gel. We recommend including the DSA in future microbicide trials involving vaginal gels in order to identify participants who have low adherence to dosing regimens. In doing so, we can develop strategies to improve adherence as well as investigate the association between product use and efficacy. PMID:21992983

  11. Applying the Mixed Methods Instrument Development and Construct Validation Process: the Transformative Experience Questionnaire

    ERIC Educational Resources Information Center

    Koskey, Kristin L. K.; Sondergeld, Toni A.; Stewart, Victoria C.; Pugh, Kevin J.

    2018-01-01

    Onwuegbuzie and colleagues proposed the Instrument Development and Construct Validation (IDCV) process as a mixed methods framework for creating and validating measures. Examples applying IDCV are lacking. We provide an illustrative case integrating the Rasch model and cognitive interviews applied to the development of the Transformative…

  12. [Translation and validation in French of the First-Time Father Questionnaire].

    PubMed

    Capponi, I; Carquillat, P; Premberg, Å; Vendittelli, F; Guittier, M-J

    2016-09-01

    For fathers, being present at a birth for the first time is not an insignificant event. Witnessing suffering can cause feelings of loneliness and powerlessness, which may be associated with postnatal problems such as depression. However, without a confirmed French-language tool concerning the experience of childbirth for fathers, we are limited in our ability to develop our understanding of their experiences and establish links between these experiences and their distress (anxiety, depression, etc.), or to develop appropriate methods of support. Our objective has been to translate and validate the Swedish "First-Time Father Questionnaire" with a French-speaking sample. The tool was translated using a translation/backtranslation process (using two independent agencies, with a pre-test on 30 new fathers as well as exchanges with the Swedish authors). The French version was then tested with 154 new fathers at 1 month post-partum. Factorial analysis followed by multi-trait analysis and variance analyses were conducted, with subgroups contrasted according to the mode of delivery. The factorial structure is satisfactory, retaining 19 items and reproducing 54.12% of variance. Professional support, worry, and prenatal preparation constitute the 3 dimensions of this. Internal consistency, homogeneity, and the discriminating capacity of the questionnaire are good. Validation of the questionnaire shows good metrological qualities. It can therefore be used in the perinatal field to evaluate the childbirth experience for first-time fathers. Copyright © 2016 Elsevier Masson SAS. All rights reserved.

  13. Model and experiences of initiating collaboration with traditional healers in validation of ethnomedicines for HIV/AIDS in Namibia

    PubMed Central

    Chinsembu, Kazhila C

    2009-01-01

    Many people with Human Immunodeficiency Virus/Acquired Immunodeficiency Syndrome (HIV/AIDS) in Namibia have access to antiretroviral drugs but some still use traditional medicines to treat opportunistic infections and offset side-effects from antiretroviral medication. Namibia has a rich biodiversity of indigenous plants that could contain novel anti-HIV agents. However, such medicinal plants have not been identified and properly documented. Various ethnomedicines used to treat HIV/AIDS opportunistic infections have not been scientifically validated for safety and efficacy. These limitations are mostly attributable to the lack of collaboration between biomedical scientists and traditional healers. This paper presents a five-step contextual model for initiating collaboration with Namibian traditional healers in order that candidate plants that may contain novel anti-HIV agents are identified, and traditional medicines used to treat HIV/AIDS opportunistic infections are subjected to scientific validation. The model includes key structures and processes used to initiate collaboration with traditional healers in Namibia; namely, the National Biosciences Forum, a steering committee with the University of Namibia (UNAM) as the focal point, a study tour to Zambia and South Africa where other collaborative frameworks were examined, commemorations of the African Traditional Medicine Day (ATMD), and consultations with stakeholders in north-eastern Namibia. Experiences from these structures and processes are discussed. All traditional healers in north-eastern Namibia were willing to collaborate with UNAM in order that their traditional medicines could be subjected to scientific validation. The current study provides a framework for future collaboration with traditional healers and the selection of candidate anti-HIV medicinal plants and ethnomedicines for scientific testing in Namibia. PMID:19852791

  14. Design and Validation of an Augmented Reality System for Laparoscopic Surgery in a Real Environment

    PubMed Central

    López-Mir, F.; Naranjo, V.; Fuertes, J. J.; Alcañiz, M.; Bueno, J.; Pareja, E.

    2013-01-01

    Purpose. This work presents the protocol carried out in the development and validation of an augmented reality system which was installed in an operating theatre to help surgeons with trocar placement during laparoscopic surgery. The purpose of this validation is to demonstrate the improvements that this system can provide to the field of medicine, particularly surgery. Method. Two experiments that were noninvasive for both the patient and the surgeon were designed. In one of these experiments the augmented reality system was used, the other one was the control experiment, and the system was not used. The type of operation selected for all cases was a cholecystectomy due to the low degree of complexity and complications before, during, and after the surgery. The technique used in the placement of trocars was the French technique, but the results can be extrapolated to any other technique and operation. Results and Conclusion. Four clinicians and ninety-six measurements obtained of twenty-four patients (randomly assigned in each experiment) were involved in these experiments. The final results show an improvement in accuracy and variability of 33% and 63%, respectively, in comparison to traditional methods, demonstrating that the use of an augmented reality system offers advantages for trocar placement in laparoscopic surgery. PMID:24236293

  15. FastaValidator: an open-source Java library to parse and validate FASTA formatted sequences.

    PubMed

    Waldmann, Jost; Gerken, Jan; Hankeln, Wolfgang; Schweer, Timmy; Glöckner, Frank Oliver

    2014-06-14

    Advances in sequencing technologies challenge the efficient importing and validation of FASTA formatted sequence data which is still a prerequisite for most bioinformatic tools and pipelines. Comparative analysis of commonly used Bio*-frameworks (BioPerl, BioJava and Biopython) shows that their scalability and accuracy is hampered. FastaValidator represents a platform-independent, standardized, light-weight software library written in the Java programming language. It targets computer scientists and bioinformaticians writing software which needs to parse quickly and accurately large amounts of sequence data. For end-users FastaValidator includes an interactive out-of-the-box validation of FASTA formatted files, as well as a non-interactive mode designed for high-throughput validation in software pipelines. The accuracy and performance of the FastaValidator library qualifies it for large data sets such as those commonly produced by massive parallel (NGS) technologies. It offers scientists a fast, accurate and standardized method for parsing and validating FASTA formatted sequence data.

  16. Are awareness questionnaires valid? Investigating the use of posttest questionnaires for assessing awareness in implicit memory tests.

    PubMed

    Barnhardt, Terrence M; Geraci, Lisa

    2008-01-01

    Two experiments--one employing a perceptual implicit memory test and the other a conceptual implicit memory test--investigated the validity of posttest questionnaires for determining the incidence of awareness in implicit memory tests. In both experiments, a condition in which none of the studied words could be used as test responses (i.e., the none-studied condition) was compared with a standard implicit test condition. Results showed that reports of awareness on the posttest questionnaire were much less frequent in the none-studied condition than in the standard condition. This was especially true after deep processing at study. In both experiments, 83% of the participants in the none-studied condition stated they were unaware even though there were strong demands for claiming awareness. Although there was a small bias in the questionnaire (i.e., 17% of the participants in the none-studied condition stated they were aware), overall, there was strong support for the validity of awareness questionnaires.

  17. SDG and qualitative trend based model multiple scale validation

    NASA Astrophysics Data System (ADS)

    Gao, Dong; Xu, Xin; Yin, Jianjin; Zhang, Hongyu; Zhang, Beike

    2017-09-01

    Verification, Validation and Accreditation (VV&A) is key technology of simulation and modelling. For the traditional model validation methods, the completeness is weak; it is carried out in one scale; it depends on human experience. The SDG (Signed Directed Graph) and qualitative trend based multiple scale validation is proposed. First the SDG model is built and qualitative trends are added to the model. And then complete testing scenarios are produced by positive inference. The multiple scale validation is carried out by comparing the testing scenarios with outputs of simulation model in different scales. Finally, the effectiveness is proved by carrying out validation for a reactor model.

  18. Design and validation of instruments to measure knowledge.

    PubMed

    Elliott, T E; Regal, R R; Elliott, B A; Renier, C M

    2001-01-01

    Measuring health care providers' learning after they have participated in educational interventions that use experimental designs requires valid, reliable, and practical instruments. A literature review was conducted. In addition, experience gained from designing and validating instruments for measuring the effect of an educational intervention informed this process. The eight main steps for designing, validating, and testing the reliability of instruments for measuring learning outcomes are presented. The key considerations and rationale for this process are discussed. Methods for critiquing and adapting existent instruments and creating new ones are offered. This study may help other investigators in developing valid, reliable, and practical instruments for measuring the outcomes of educational activities.

  19. Use of Bayesian Networks to Probabilistically Model and Improve the Likelihood of Validation of Microarray Findings by RT-PCR

    PubMed Central

    English, Sangeeta B.; Shih, Shou-Ching; Ramoni, Marco F.; Smith, Lois E.; Butte, Atul J.

    2014-01-01

    Though genome-wide technologies, such as microarrays, are widely used, data from these methods are considered noisy; there is still varied success in downstream biological validation. We report a method that increases the likelihood of successfully validating microarray findings using real time RT-PCR, including genes at low expression levels and with small differences. We use a Bayesian network to identify the most relevant sources of noise based on the successes and failures in validation for an initial set of selected genes, and then improve our subsequent selection of genes for validation based on eliminating these sources of noise. The network displays the significant sources of noise in an experiment, and scores the likelihood of validation for every gene. We show how the method can significantly increase validation success rates. In conclusion, in this study, we have successfully added a new automated step to determine the contributory sources of noise that determine successful or unsuccessful downstream biological validation. PMID:18790084

  20. Driving simulator validation of driver behavior with limited safe vantage points for data collection in work zones.

    PubMed

    Bham, Ghulam H; Leu, Ming C; Vallati, Manoj; Mathur, Durga R

    2014-06-01

    This study is aimed at validating a driving simulator (DS) for the study of driver behavior in work zones. A validation study requires field data collection. For studies conducted in highway work zones, the availability of safe vantage points for data collection at critical locations can be a significant challenge. A validation framework is therefore proposed in this paper, demonstrated using a fixed-based DS that addresses the issue by using a global positioning system (GPS). The validation of the DS was conducted using objective and subjective evaluations. The objective validation was divided into qualitative and quantitative evaluations. The DS was validated by comparing the results of simulation with the field data, which were collected using a GPS along the highway and video recordings at specific locations in a work zone. The constructed work zone scenario in the DS was subjectively evaluated with 46 participants. The objective evaluation established the absolute and relative validity of the DS. The mean speeds from the DS data showed excellent agreement with the field data. The subjective evaluation indicated realistic driving experience by the participants. The use of GPS showed that continuous data collected along the highway can overcome the challenges of unavailability of safe vantage points especially at critical locations. Further, a validated DS can be used for examining driver behavior in complex situations by replicating realistic scenarios. Copyright © 2014 Elsevier Ltd. All rights reserved.

  1. Retrieval and validation of carbon dioxide, methane and water vapor for the Canary Islands IR-laser occultation experiment

    NASA Astrophysics Data System (ADS)

    Proschek, V.; Kirchengast, G.; Schweitzer, S.; Brooke, J. S. A.; Bernath, P. F.; Thomas, C. B.; Wang, J.-G.; Tereszchuk, K. A.; González Abad, G.; Hargreaves, R. J.; Beale, C. A.; Harrison, J. J.; Martin, P. A.; Kasyutich, V. L.; Gerbig, C.; Loescher, A.

    2015-08-01

    The first ground-based experiment to prove the concept of a novel space-based observation technique for microwave and infrared-laser occultation between low-Earth-orbit satellites was performed in the Canary Islands between La Palma and Tenerife. For two nights from 21 to 22 July 2011 the experiment delivered the infrared-laser differential transmission principle for the measurement of greenhouse gases (GHGs) in the free atmosphere. Such global and long-term stable measurements of GHGs, accompanied also by measurements of thermodynamic parameters and line-of-sight wind in a self-calibrating way, have become very important for climate change monitoring. The experiment delivered promising initial data for demonstrating the new observation concept by retrieving volume mixing ratios of GHGs along a ~144 km signal path at altitudes of ~2.4 km. Here, we present a detailed analysis of the measurements, following a recent publication that introduced the experiment's technical setup and first results for an example retrieval of CO2. We present the observational and validation data sets, the latter simultaneously measured at the transmitter and receiver sites; the measurement data handling; and the differential transmission retrieval procedure. We also determine the individual and combined uncertainties influencing the results and present the retrieval results for 12CO2, 13CO2, C18OO, H2O and CH4. The new method is found to have a reliable basis for monitoring of greenhouse gases such as CO2, CH4, and H2O in the free atmosphere.

  2. Calibration and validation of toxicokinetic-toxicodynamic models for three neonicotinoids and some aquatic macroinvertebrates.

    PubMed

    Focks, Andreas; Belgers, Dick; Boerwinkel, Marie-Claire; Buijse, Laura; Roessink, Ivo; Van den Brink, Paul J

    2018-05-01

    Exposure patterns in ecotoxicological experiments often do not match the exposure profiles for which a risk assessment needs to be performed. This limitation can be overcome by using toxicokinetic-toxicodynamic (TKTD) models for the prediction of effects under time-variable exposure. For the use of TKTD models in the environmental risk assessment of chemicals, it is required to calibrate and validate the model for specific compound-species combinations. In this study, the survival of macroinvertebrates after exposure to the neonicotinoid insecticide was modelled using TKTD models from the General Unified Threshold models of Survival (GUTS) framework. The models were calibrated on existing survival data from acute or chronic tests under static exposure regime. Validation experiments were performed for two sets of species-compound combinations: one set focussed on multiple species sensitivity to a single compound: imidacloprid, and the other set on the effects of multiple compounds for a single species, i.e., the three neonicotinoid compounds imidacloprid, thiacloprid and thiamethoxam, on the survival of the mayfly Cloeon dipterum. The calibrated models were used to predict survival over time, including uncertainty ranges, for the different time-variable exposure profiles used in the validation experiments. From the comparison between observed and predicted survival, it appeared that the accuracy of the model predictions was acceptable for four of five tested species in the multiple species data set. For compounds such as neonicotinoids, which are known to have the potential to show increased toxicity under prolonged exposure, the calibration and validation of TKTD models for survival needs to be performed ideally by considering calibration data from both acute and chronic tests.

  3. Validation of stratospheric aerosol and gas experiments 1 and 2 satellite aerosol optical depth measurements using surface radiometer data

    NASA Technical Reports Server (NTRS)

    Kent, G. S.; Mccormick, M. P.; Wang, P.-H.

    1994-01-01

    The stratospheric aerosol measurement 2, stratospheric aerosol and gas experiment (SAGE) 1, and SAGE 2 series of solar occultation satellite instruments were designed for the study of stratospheric aerosols and gases and have been extensively validated in the stratosphere. They are also capable, under cloud-free conditions, of measuring the extinction due to aerosols in the troposphere. Such tropospheric extinction measurements have yet to be validated by appropriate lidar and in situ techniques. In this paper published atmospheric aerosol optical depth measurements, made from high-altitude observatories during volcanically quiet periods, have been compared with optical depths calculated from local SAGE 1 and SAGE 2 extinction profiles. Surface measurements from three such observatories have been used, one located in Hawaii and two within the continental United States. Data have been intercompared on a seasonal basis at wave-lenths between 0.5 and 1.0 micron and found to agree within the range of measurement errors and expected atmospheric variation. The mean rms difference between the optical depths for corresponding satellite and surface measured data sets is 29%, and the mean ratio of the optical depths is 1.09.

  4. Blast Load Simulator Experiments for Computational Model Validation: Report 2

    DTIC Science & Technology

    2017-02-01

    repeatability. The uncertainty in the experimental pressures and impulses was evaluated by computing 95% confidence intervals on the results. DISCLAIMER: The...Experiment uncertainty The uncertainty in the experimental pressure and impulse was evaluated for the five replicate experiments for which, as closely as...comparisons were made among the replicated experiments to evaluate repeatability. The uncertainty in the experimental pressures and impulses was

  5. Empirical Validation and Application of the Computing Attitudes Survey

    ERIC Educational Resources Information Center

    Dorn, Brian; Elliott Tew, Allison

    2015-01-01

    Student attitudes play an important role in shaping learning experiences. However, few validated instruments exist for measuring student attitude development in a discipline-specific way. In this paper, we present the design, development, and validation of the computing attitudes survey (CAS). The CAS is an extension of the Colorado Learning…

  6. SAGE Validations of Volcanic Jet Simulations

    NASA Astrophysics Data System (ADS)

    Peterson, A. H.; Wohletz, K. H.; Ogden, D. E.; Gisler, G.; Glatzmaier, G.

    2006-12-01

    The SAGE (SAIC Adaptive Grid Eulerian) code employs adaptive mesh refinement in solving Eulerian equations of complex fluid flow desirable for simulation of volcanic eruptions. Preliminary eruption simulations demonstrate its ability to resolve multi-material flows over large domains where dynamics are concentrated in small regions. In order to validate further application of this code to numerical simulation of explosive eruption phenomena, we focus on one of the fundamental physical processes important to the problem, namely the dynamics of an underexpanded jet. Observations of volcanic eruption plumes and laboratory experiments on analog systems document the eruption of overpressured fluid in a supersonic jet that is governed by vent diameter and level of overpressure. The jet is dominated by inertia (very high Reynolds number) and feeds a thermally convective plume controlled by turbulent admixture of the atmosphere. The height above the vent at which the jet looses its inertia is important to know for convective plume predictions that are used to calculate atmospheric dispersal of volcanic products. We simulate a set of well documented laboratory experiments that provide detail on underexpanded jet structure by gas density contours, showing the shape and size of the Mach stem. SAGE results are within several percent of the experiments for position and density of the incident (intercepting) and reflected shocks, slip lines, shear layers, and Mach disk. The simulations also resolve vorticity at the jet margins near the Mach disk, showing turbulent velocity fields down to a scale of 30 micrometers. Benchmarking these results with those of CFDLib (Los Alamos National Laboratory), which solves the full Navier-Stokes equations (includes viscous stress tensor), shows close agreement, indicating that adaptive mesh refinement used in SAGE may offset the need for explicit calculation of viscous dissipation.

  7. OECD-NEA Expert Group on Multi-Physics Experimental Data, Benchmarks and Validation

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Valentine, Timothy; Rohatgi, Upendra S.

    High-fidelity, multi-physics modeling and simulation (M&S) tools are being developed and utilized for a variety of applications in nuclear science and technology and show great promise in their abilities to reproduce observed phenomena for many applications. Even with the increasing fidelity and sophistication of coupled multi-physics M&S tools, the underpinning models and data still need to be validated against experiments that may require a more complex array of validation data because of the great breadth of the time, energy and spatial domains of the physical phenomena that are being simulated. The Expert Group on Multi-Physics Experimental Data, Benchmarks and Validationmore » (MPEBV) of the Nuclear Energy Agency (NEA) of the Organization for Economic Cooperation and Development (OECD) was formed to address the challenges with the validation of such tools. The work of the MPEBV expert group is shared among three task forces to fulfill its mandate and specific exercises are being developed to demonstrate validation principles for common industrial challenges. This paper describes the overall mission of the group, the specific objectives of the task forces, the linkages among the task forces, and the development of a validation exercise that focuses on a specific reactor challenge problem.« less

  8. Face validity, construct validity and training benefits of a virtual reality TURP simulator.

    PubMed

    Bright, Elizabeth; Vine, Samuel; Wilson, Mark R; Masters, Rich S W; McGrath, John S

    2012-01-01

    To assess face validity, construct validity and the training benefits of a virtual reality TURP simulator. 11 novices (no TURP experience) and 7 experts (>200 TURP's) completed a virtual reality median lobe prostate resection task on the TURPsim™ (Simbionix USA Corp., Cleveland, OH). Performance indicators (percentage of prostate resected (PR), percentage of capsular resection (CR) and time diathermy loop active without tissue contact (TAWC) were recorded via the TURPsim™ and compared between novices and experts to assess construct validity. Verbal comments provided by experts following task completion were used to assess face validity. Repeated attempts of the task by the novices were analysed to assess the training benefits of the TURPsim™. Experts resected a significantly greater percentage of prostate per minute (p < 0.01) and had significantly less active diathermy time without tissue contact (p < 0.01) than novices. After practice, novices were able to perform the simulation more effectively, with significant improvement in all measured parameters. Improvement in performance was noted in novices following repetitive training, as evidenced by improved TAWC scores that were not significantly different from the expert group (p = 0.18). This study has established face and construct validity for the TURPsim™. The potential benefit in using this tool to train novices has also been demonstrated. Copyright © 2012 Surgical Associates Ltd. Published by Elsevier Ltd. All rights reserved.

  9. Nuclear Energy Knowledge and Validation Center (NEKVaC) Needs Workshop Summary Report

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Gougar, Hans

    2015-02-01

    The Department of Energy (DOE) has made significant progress developing simulation tools to predict the behavior of nuclear systems with greater accuracy and of increasing our capability to predict the behavior of these systems outside of the standard range of applications. These analytical tools require a more complex array of validation tests to accurately simulate the physics and multiple length and time scales. Results from modern simulations will allow experiment designers to narrow the range of conditions needed to bound system behavior and to optimize the deployment of instrumentation to limit the breadth and cost of the campaign. Modern validation,more » verification and uncertainty quantification (VVUQ) techniques enable analysts to extract information from experiments in a systematic manner and provide the users with a quantified uncertainty estimate. Unfortunately, the capability to perform experiments that would enable taking full advantage of the formalisms of these modern codes has progressed relatively little (with some notable exceptions in fuels and thermal-hydraulics); the majority of the experimental data available today is the "historic" data accumulated over the last decades of nuclear systems R&D. A validated code-model is a tool for users. An unvalidated code-model is useful for code developers to gain understanding, publish research results, attract funding, etc. As nuclear analysis codes have become more sophisticated, so have the measurement and validation methods and the challenges that confront them. A successful yet cost-effective validation effort requires expertise possessed only by a few, resources possessed only by the well-capitalized (or a willing collective), and a clear, well-defined objective (validating a code that is developed to satisfy the need(s) of an actual user). To that end, the Idaho National Laboratory established the Nuclear Energy Knowledge and Validation Center to address the challenges of modern code validation

  10. Finite element analysis of dental implants with validation: to what extent can we expect the model to predict biological phenomena? A literature review and proposal for classification of a validation process.

    PubMed

    Chang, Yuanhan; Tambe, Abhijit Anil; Maeda, Yoshinobu; Wada, Masahiro; Gonda, Tomoya

    2018-03-08

    A literature review of finite element analysis (FEA) studies of dental implants with their model validation process was performed to establish the criteria for evaluating validation methods with respect to their similarity to biological behavior. An electronic literature search of PubMed was conducted up to January 2017 using the Medical Subject Headings "dental implants" and "finite element analysis." After accessing the full texts, the context of each article was searched using the words "valid" and "validation" and articles in which these words appeared were read to determine whether they met the inclusion criteria for the review. Of 601 articles published from 1997 to 2016, 48 that met the eligibility criteria were selected. The articles were categorized according to their validation method as follows: in vivo experiments in humans (n = 1) and other animals (n = 3), model experiments (n = 32), others' clinical data and past literature (n = 9), and other software (n = 2). Validation techniques with a high level of sufficiency and efficiency are still rare in FEA studies of dental implants. High-level validation, especially using in vivo experiments tied to an accurate finite element method, needs to become an established part of FEA studies. The recognition of a validation process should be considered when judging the practicality of an FEA study.

  11. Best in show but not best shape: a photographic assessment of show dog body condition.

    PubMed

    Such, Z R; German, A J

    2015-08-01

    Previous studies suggest that owners often wrongly perceive overweight dogs to be in normal condition. The body shape of dogs attending shows might influence owners' perceptions, with online images of overweight show winners having a negative effect. This was an observational in silico study of canine body condition. 14 obese-prone breeds and 14 matched non-obese-probe breeds were first selected, and one operator then used an online search engine to identify 40 images, per breed, of dogs that had appeared at a major national UK show (Crufts). After images were anonymised and coded, a second observer subjectively assessed body condition, in a single sitting, using a previously validated method. Of 1120 photographs initially identified, 960 were suitable for assessing body condition, with all unsuitable images being from longhaired breeds. None of the dogs (0 per cent) were underweight, 708 (74 per cent) were in ideal condition and 252 (26 per cent) were overweight. Pugs, basset hounds and Labrador retrievers were most likely to be overweight, while standard poodles, Rhodesian ridgebacks, Hungarian vizslas and Dobermanns were least likely to be overweight. Given the proportion of show dogs from some breeds that are overweight, breed standards should be redefined to be consistent with a dog in optimal body condition. British Veterinary Association.

  12. The Second Victim Experience and Support Tool: Validation of an Organizational Resource for Assessing Second Victim Effects and the Quality of Support Resources.

    PubMed

    Burlison, Jonathan D; Scott, Susan D; Browne, Emily K; Thompson, Sierra G; Hoffman, James M

    2017-06-01

    Medical errors and unanticipated negative patient outcomes can damage the well-being of health care providers. These affected individuals, referred to as "second victims," can experience various psychological and physical symptoms. Support resources provided by health care organizations to prevent and reduce second victim-related harm are often inadequate. In this study, we present the development and psychometric evaluation of the Second Victim Experience and Support Tool (SVEST), a survey instrument that can assist health care organizations to implement and track the performance of second victim support resources. The SVEST (29 items representing 7 dimensions and 2 outcome variables) was completed by 303 health care providers involved in direct patient care. The survey collected responses on second victim-related psychological and physical symptoms and the quality of support resources. Desirability of possible support resources was also measured. The SVEST was assessed for content validity, internal consistency, and construct validity with confirmatory factor analysis. Confirmatory factor analysis results suggested good model fit for the survey. Cronbach α reliability scores for the survey dimensions ranged from 0.61 to 0.89. The most desired second victim support option was "A respected peer to discuss the details of what happened." The SVEST can be used by health care organizations to evaluate second victim experiences of their staff and the quality of existing support resources. It can also provide health care organization leaders with information on second victim-related support resources most preferred by their staff. The SVEST can be administered before and after implementing new second victim resources to measure perceptions of effectiveness.

  13. Fractal Clustering and Knowledge-driven Validation Assessment for Gene Expression Profiling.

    PubMed

    Wang, Lu-Yong; Balasubramanian, Ammaiappan; Chakraborty, Amit; Comaniciu, Dorin

    2005-01-01

    DNA microarray experiments generate a substantial amount of information about the global gene expression. Gene expression profiles can be represented as points in multi-dimensional space. It is essential to identify relevant groups of genes in biomedical research. Clustering is helpful in pattern recognition in gene expression profiles. A number of clustering techniques have been introduced. However, these traditional methods mainly utilize shape-based assumption or some distance metric to cluster the points in multi-dimension linear Euclidean space. Their results shows poor consistence with the functional annotation of genes in previous validation study. From a novel different perspective, we propose fractal clustering method to cluster genes using intrinsic (fractal) dimension from modern geometry. This method clusters points in such a way that points in the same clusters are more self-affine among themselves than to the points in other clusters. We assess this method using annotation-based validation assessment for gene clusters. It shows that this method is superior in identifying functional related gene groups than other traditional methods.

  14. Are we puppets on a string? Comparing the impact of contingency and validity on implicit and explicit evaluations.

    PubMed

    Peters, Kurt R; Gawronski, Bertram

    2011-04-01

    Research has demonstrated that implicit and explicit evaluations of the same object can diverge. Explanations of such dissociations frequently appeal to dual-process theories, such that implicit evaluations are assumed to reflect object-valence contingencies independent of their perceived validity, whereas explicit evaluations reflect the perceived validity of object-valence contingencies. Although there is evidence supporting these assumptions, it remains unclear if dissociations can arise in situations in which object-valence contingencies are judged to be true or false during the learning of these contingencies. Challenging dual-process accounts that propose a simultaneous operation of two parallel learning mechanisms, results from three experiments showed that the perceived validity of evaluative information about social targets qualified both explicit and implicit evaluations when validity information was available immediately after the encoding of the valence information; however, delaying the presentation of validity information reduced its qualifying impact for implicit, but not explicit, evaluations.

  15. Virtual Model Validation of Complex Multiscale Systems: Applications to Nonlinear Elastostatics

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Oden, John Tinsley; Prudencio, Ernest E.; Bauman, Paul T.

    We propose a virtual statistical validation process as an aid to the design of experiments for the validation of phenomenological models of the behavior of material bodies, with focus on those cases in which knowledge of the fabrication process used to manufacture the body can provide information on the micro-molecular-scale properties underlying macroscale behavior. One example is given by models of elastomeric solids fabricated using polymerization processes. We describe a framework for model validation that involves Bayesian updates of parameters in statistical calibration and validation phases. The process enables the quanti cation of uncertainty in quantities of interest (QoIs) andmore » the determination of model consistency using tools of statistical information theory. We assert that microscale information drawn from molecular models of the fabrication of the body provides a valuable source of prior information on parameters as well as a means for estimating model bias and designing virtual validation experiments to provide information gain over calibration posteriors.« less

  16. Validation protocols for blood pressure-measuring devices: status quo and development needs.

    PubMed

    Beime, Beate; Deutsch, Cornelia; Gomez, Timothy; Zwingers, Thomas; Mengden, Thomas; Bramlage, Peter

    2016-02-01

    Hypertension is a major risk factor for cardiovascular morbidity and mortality. Therefore, blood pressure self-measuring devices have emerged as valuable tools in patient care and the accuracy of these instruments is of fundamental importance. For this reason, several validation procedures for assessing the efficacy of blood pressure monitoring devices have been developed, including protocols by the Association for the Advancement of Medical Instrumentation, the British Hypertension Society, the German Hypertension League (Prüfsiegelprotokoll), and the International Protocol of the Working Group on Blood Pressure Monitoring of the European Society of Hypertension. In the past, most of the protocols have been reviewed and modified because of experiences gained during the validation studies carried out. However, each shows distinct differences, that is number and characteristics of patients required, blood pressure ranges, and the length of the validation procedure, which may result in unique advantages and/or limitations associated with their use. The continued standardization and evolution of these guidelines is essential to ensure the efficacy of blood pressure-measuring devices marketed for clinical and home use. Here, we aimed to compare four currently used validation protocols and to initiate a discussion on potential future improvements.

  17. Characterization of Psychotic Experiences in Adolescence Using the Specific Psychotic Experiences Questionnaire: Findings From a Study of 5000 16-Year-Old Twins

    PubMed Central

    Ronald, Angelica; Sieradzka, Dominika; Cardno, Alastair G.; Haworth, Claire M. A.; McGuire, Philip; Freeman, Daniel

    2014-01-01

    We aimed to characterize multiple psychotic experiences, each assessed on a spectrum of severity (ie, quantitatively), in a general population sample of adolescents. Over five thousand 16-year-old twins and their parents completed the newly devised Specific Psychotic Experiences Questionnaire (SPEQ); a subsample repeated it approximately 9 months later. SPEQ was investigated in terms of factor structure, intersubscale correlations, frequency of endorsement and reported distress, reliability and validity, associations with traits of anxiety, depression and personality, and sex differences. Principal component analysis revealed a 6-component solution: paranoia, hallucinations, cognitive disorganization, grandiosity, anhedonia, and parent-rated negative symptoms. These components formed the basis of 6 subscales. Correlations between different experiences were low to moderate. All SPEQ subscales, except Grandiosity, correlated significantly with traits of anxiety, depression, and neuroticism. Scales showed good internal consistency, test-retest reliability, and convergent validity. Girls endorsed more paranoia, hallucinations, and cognitive disorganization; boys reported more grandiosity and anhedonia and had more parent-rated negative symptoms. As in adults at high risk for psychosis and with psychotic disorders, psychotic experiences in adolescents are characterized by multiple components. The study of psychotic experiences as distinct dimensional quantitative traits is likely to prove an important strategy for future research, and the SPEQ is a self- and parent-report questionnaire battery that embodies this approach. PMID:24062593

  18. Construct validity of the LapVR virtual-reality surgical simulator.

    PubMed

    Iwata, Naoki; Fujiwara, Michitaka; Kodera, Yasuhiro; Tanaka, Chie; Ohashi, Norifumi; Nakayama, Goro; Koike, Masahiko; Nakao, Akimasa

    2011-02-01

    Laparoscopic surgery requires fundamental skills peculiar to endoscopic procedures such as eye-hand coordination. Acquisition of such skills prior to performing actual surgery is highly desirable for favorable outcome. Virtual-reality simulators have been developed for both surgical training and assessment of performance. The aim of the current study is to show construct validity of a novel simulator, LapVR (Immersion Medical, San Jose, CA, USA), for Japanese surgeons and surgical residents. Forty-four subjects were divided into the following three groups according to their experience in laparoscopic surgery: 14 residents (RE) with no experience in laparoscopic surgery, 14 junior surgeons (JR) with little experience, and 16 experienced surgeons (EX). All subjects executed "essential task 1" programmed in the LapVR, which consists of six tasks, resulting in automatic measurement of 100 parameters indicating various aspects of laparoscopic skills. Time required for each task tended to be inversely correlated with experience in laparoscopic surgery. For the peg transfer skill, statistically significant differences were observed between EX and RE in three parameters, including total time and average time taken to complete the procedure and path length for the nondominant hand. For the cutting skill, similar differences were observed between EX and RE in total time, number of unsuccessful cutting attempts, and path length for the nondominant hand. According to the programmed comprehensive evaluation, performance in terms of successful completion of the task and actual experience of the participants in laparoscopic surgery correlated significantly for the peg transfer (P=0.007) and cutting skills (P=0.026). The peg transfer and cutting skills could best distinguish between EX and RE. This study is the first to provide evidence that LapVR has construct validity to discriminate between novice and experienced laparoscopic surgeons.

  19. Validity in the hiring and evaluation process.

    PubMed

    Gregg, Robert E

    2006-01-01

    Validity means "based on sound principles." Hiring decisions, discharges, and layoffs are often challenged in court. Unfortunately the employer's defenses are too often found "invalid." The Americans With Disabilities Act requires the employer to show a "validated" hiring process. Defense of discharges or layoffs often focuses on validity of the employer's decision. This article explains the elements of validity needed for sound and defendable employment decisions.

  20. The regression discontinuity design showed to be a valid alternative to a randomized controlled trial for estimating treatment effects.

    PubMed

    Maas, Iris L; Nolte, Sandra; Walter, Otto B; Berger, Thomas; Hautzinger, Martin; Hohagen, Fritz; Lutz, Wolfgang; Meyer, Björn; Schröder, Johanna; Späth, Christina; Klein, Jan Philipp; Moritz, Steffen; Rose, Matthias

    2017-02-01

    To compare treatment effect estimates obtained from a regression discontinuity (RD) design with results from an actual randomized controlled trial (RCT). Data from an RCT (EVIDENT), which studied the effect of an Internet intervention on depressive symptoms measured with the Patient Health Questionnaire (PHQ-9), were used to perform an RD analysis, in which treatment allocation was determined by a cutoff value at baseline (PHQ-9 = 10). A linear regression model was fitted to the data, selecting participants above the cutoff who had received the intervention (n = 317) and control participants below the cutoff (n = 187). Outcome was PHQ-9 sum score 12 weeks after baseline. Robustness of the effect estimate was studied; the estimate was compared with the RCT treatment effect. The final regression model showed a regression coefficient of -2.29 [95% confidence interval (CI): -3.72 to -.85] compared with a treatment effect found in the RCT of -1.57 (95% CI: -2.07 to -1.07). Although the estimates obtained from two designs are not equal, their confidence intervals overlap, suggesting that an RD design can be a valid alternative for RCTs. This finding is particularly important for situations where an RCT may not be feasible or ethical as is often the case in clinical research settings. Copyright © 2016 Elsevier Inc. All rights reserved.

  1. The Validity and Incremental Validity of Knowledge Tests, Low-Fidelity Simulations, and High-Fidelity Simulations for Predicting Job Performance in Advanced-Level High-Stakes Selection

    ERIC Educational Resources Information Center

    Lievens, Filip; Patterson, Fiona

    2011-01-01

    In high-stakes selection among candidates with considerable domain-specific knowledge and experience, investigations of whether high-fidelity simulations (assessment centers; ACs) have incremental validity over low-fidelity simulations (situational judgment tests; SJTs) are lacking. Therefore, this article integrates research on the validity of…

  2. Validation of Competences and Professionalisation of Teachers and Trainers = Validation des Acquis et Professionnalisation des Enseignants et Formateurs. CEDEFOP Dossier Series.

    ERIC Educational Resources Information Center

    de Blignieres-Legeraud, Anne; Bjornavold, Jens; Charraud, Anne-Marie; Gerard, Francoise; Diamanti, Stamatina; Freundlinger, Alfred; Bjerknes, Ellen; Covita, Horacio

    A workshop aimed to clarify under what conditions the validation of knowledge gained through experience can be considered a professionalizing factor for European Union teachers and trainers by creating a better link between experience and training and between vocational training and qualifications. Seven papers were presented in addition to an…

  3. Numerical Investigation of the Performance of a Supersonic Combustion Chamber and Comparison with Experiments

    NASA Astrophysics Data System (ADS)

    Banica, M. C.; Chun, J.; Scheuermann, T.; Weigand, B.; Wolfersdorf, J. v.

    2009-01-01

    Scramjet powered vehicles can decrease costs for access to space but substantial obstacles still exist in their realization. For example, experiments in the relevant Mach number regime are difficult to perform and flight testing is expensive. Therefore, numerical methods are often employed for system layout but they require validation against experimental data. Here, we validate the commercial code CFD++ against experimental results for hydrogen combustion in the supersonic combustion facility of the Institute of Aerospace Thermodynamics (ITLR) at the Universität Stuttgart. Fuel is injected through a lobed a strut injector, which provides rapid mixing. Our numerical data shows reasonable agreement with experiments. We further investigate effects of varying equivalence ratios on several important performance parameters.

  4. The daily spiritual experiences scale and well-being: demographic comparisons and scale validation with older jewish adults and a diverse internet sample.

    PubMed

    Kalkstein, Solomon; Tower, Roni Beth

    2009-12-01

    A substantive literature connects spirituality to positive physical, social, and mental health. In this study, the Daily Spiritual Experiences Scale (DSES) was administered to 410 subjects who participated in a community study and to 87 residents at the Hebrew Home for the Aged at Riverdale (HHAR), the latter sample consisting primarily of older Jewish respondents. Internal consistency of the DSES in both samples was high and exploratory factor analyses revealed one dominant factor and a second factor, which included 14 and 2 items, respectively, consistent with the scale's original validation (Underwood and Teresi 2002). Demographic subgroup comparison among religious groups revealed significantly fewer daily spiritual experiences among Jews, and lowest scores among those respondents endorsing no religious affiliation. Women exhibited more frequent daily experience than men, and attainment of higher levels of education was associated with less frequent daily spiritual experience. All but one of the outcome measures of physical and psychologic well-being were found to be positively associated with the DSES so that more frequent daily spiritual experience correlated with less psychopathology, more close friendships, and better self-rated health. Directions for future research, study interpretation and limitations, and clinical implications for use of the DSES are discussed.

  5. Validity of black hole complementarity in the BTZ black hole

    NASA Astrophysics Data System (ADS)

    Gim, Yongwan; Kim, Wontae

    2018-01-01

    Based on the gedanken experiment for black hole complementarity in the Schwarzschild black hole, we calculate the energy required to duplicate information in the BTZ black hole under the assumption of absorbing boundary condition and its dual solution of the black string, respectively, in order to justify the validity of the no-cloning theorem in quantum mechanics. For the BTZ black hole, the required energy for the duplication of information can be made fairly small, whereas for the black string it exceeds the total mass of the black string, although they are related to each other under the dual transformation. So, the duplication of information might be possible in the BTZ black hole in contrast to the case of the black string, so that the no-cloning theorem could be violated for the former case. To save the duplication of information for the BTZ black hole, we perform an improved gedanken experiment by using the local thermodynamic quantities near the horizon rather than those defined at infinity, and show that the no-cloning theorem could be made valid even in the BTZ black hole. We also discuss how this local treatment for the no-cloning theorem can be applied to the black string as well as the Schwarzschild black hole innocuously.

  6. Workflow for Criticality Assessment Applied in Biopharmaceutical Process Validation Stage 1.

    PubMed

    Zahel, Thomas; Marschall, Lukas; Abad, Sandra; Vasilieva, Elena; Maurer, Daniel; Mueller, Eric M; Murphy, Patrick; Natschläger, Thomas; Brocard, Cécile; Reinisch, Daniela; Sagmeister, Patrick; Herwig, Christoph

    2017-10-12

    Identification of critical process parameters that impact product quality is a central task during regulatory requested process validation. Commonly, this is done via design of experiments and identification of parameters significantly impacting product quality (rejection of the null hypothesis that the effect equals 0). However, parameters which show a large uncertainty and might result in an undesirable product quality limit critical to the product, may be missed. This might occur during the evaluation of experiments since residual/un-modelled variance in the experiments is larger than expected a priori. Estimation of such a risk is the task of the presented novel retrospective power analysis permutation test. This is evaluated using a data set for two unit operations established during characterization of a biopharmaceutical process in industry. The results show that, for one unit operation, the observed variance in the experiments is much larger than expected a priori, resulting in low power levels for all non-significant parameters. Moreover, we present a workflow of how to mitigate the risk associated with overlooked parameter effects. This enables a statistically sound identification of critical process parameters. The developed workflow will substantially support industry in delivering constant product quality, reduce process variance and increase patient safety.

  7. The SCALE Verified, Archived Library of Inputs and Data - VALID

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Marshall, William BJ J; Rearden, Bradley T

    The Verified, Archived Library of Inputs and Data (VALID) at ORNL contains high quality, independently reviewed models and results that improve confidence in analysis. VALID is developed and maintained according to a procedure of the SCALE quality assurance (QA) plan. This paper reviews the origins of the procedure and its intended purpose, the philosophy of the procedure, some highlights of its implementation, and the future of the procedure and associated VALID library. The original focus of the procedure was the generation of high-quality models that could be archived at ORNL and applied to many studies. The review process associated withmore » model generation minimized the chances of errors in these archived models. Subsequently, the scope of the library and procedure was expanded to provide high quality, reviewed sensitivity data files for deployment through the International Handbook of Evaluated Criticality Safety Benchmark Experiments (IHECSBE). Sensitivity data files for approximately 400 such models are currently available. The VALID procedure and library continue fulfilling these multiple roles. The VALID procedure is based on the quality assurance principles of ISO 9001 and nuclear safety analysis. Some of these key concepts include: independent generation and review of information, generation and review by qualified individuals, use of appropriate references for design data and documentation, and retrievability of the models, results, and documentation associated with entries in the library. Some highlights of the detailed procedure are discussed to provide background on its implementation and to indicate limitations of data extracted from VALID for use by the broader community. Specifically, external users of data generated within VALID must take responsibility for ensuring that the files are used within the QA framework of their organization and that use is appropriate. The future plans for the VALID library include expansion to include additional

  8. [Validity of psychoprophylaxis in obstetrics. Authors' experience].

    PubMed

    D'Alfonso, A; Zaurito, V; Facchini, D; Di Stefano, L; Patacchiola, F; Cappa, F

    1990-12-01

    The Authors report the results based on 20 years of practice on obstetric psycho-prophylaxis (PPO). Data on presence at course, on frequency, on primipares/pluripares ratio, on labour, on timing and mode of delivery, are assembled. Moreover, neonatal status at birth and at 10th day of life, are investigated. The data obtained were compared with a control group, constituted by women without any treatment before delivery. The acquired experience confirm the utility of PPO in the ordinary clinical practice.

  9. Goals and Status of the NASA Juncture Flow Experiment

    NASA Technical Reports Server (NTRS)

    Rumsey, Christopher L.; Morrison, Joseph H.

    2016-01-01

    The NASA Juncture Flow experiment is a new effort whose focus is attaining validation data in the juncture region of a wing-body configuration. The experiment is designed specifically for the purpose of CFD validation. Current turbulence models routinely employed by Reynolds-averaged Navier-Stokes CFD are inconsistent in their prediction of corner flow separation in aircraft juncture regions, so experimental data in the near-wall region of such a configuration will be useful both for assessment as well as for turbulence model improvement. This paper summarizes the Juncture Flow effort to date, including preliminary risk-reduction experiments already conducted and planned future experiments. The requirements and challenges associated with conducting a quality validation test are discussed.

  10. Development and examination of the psychometric properties of the Learning Experience Scale in nursing.

    PubMed

    Takase, Miyuki; Imai, Takiko; Uemura, Chizuru

    2016-06-01

    This paper examines the psychometric properties of the Learning Experience Scale. A survey method was used to collect data from a total of 502 nurses. Data were analyzed by factor analysis and the known-groups technique to examine the construct validity of the scale. In addition, internal consistency was evaluated by Cronbach's alpha, and stability was examined by test-retest correlation. Factor analysis showed that the Learning Experience Scale consisted of five factors: learning from practice, others, training, feedback, and reflection. The scale also had the power to discriminate between nurses with high and low levels of nursing competence. The internal consistency and the stability of the scale were also acceptable. The Learning Experience Scale is a valid and reliable instrument, and helps organizations to effectively design learning interventions for nurses. © 2015 Wiley Publishing Asia Pty Ltd.

  11. Complex terrain experiments in the New European Wind Atlas

    PubMed Central

    Angelou, N.; Callies, D.; Cantero, E.; Arroyo, R. Chávez; Courtney, M.; Cuxart, J.; Dellwik, E.; Gottschall, J.; Ivanell, S.; Kühn, P.; Lea, G.; Matos, J. C.; Palma, J. M. L. M.; Peña, A.; Rodrigo, J. Sanz; Söderberg, S.; Vasiljevic, N.; Rodrigues, C. Veiga

    2017-01-01

    The New European Wind Atlas project will create a freely accessible wind atlas covering Europe and Turkey, develop the model chain to create the atlas and perform a series of experiments on flow in many different kinds of complex terrain to validate the models. This paper describes the experiments of which some are nearly completed while others are in the planning stage. All experiments focus on the flow properties that are relevant for wind turbines, so the main focus is the mean flow and the turbulence at heights between 40 and 300 m. Also extreme winds, wind shear and veer, and diurnal and seasonal variations of the wind are of interest. Common to all the experiments is the use of Doppler lidar systems to supplement and in some cases replace completely meteorological towers. Many of the lidars will be equipped with scan heads that will allow for arbitrary scan patterns by several synchronized systems. Two pilot experiments, one in Portugal and one in Germany, show the value of using multiple synchronized, scanning lidar, both in terms of the accuracy of the measurements and the atmospheric physical processes that can be studied. The experimental data will be used for validation of atmospheric flow models and will by the end of the project be freely available. This article is part of the themed issue ‘Wind energy in complex terrains’. PMID:28265025

  12. Assessment of the face validity of two pain scales in Kenya: a validation study using cognitive interviewing

    PubMed Central

    2012-01-01

    Background Patients in sub-Saharan Africa commonly experience pain, which often is un-assessed and undertreated. One hindrance to routine pain assessment in these settings is the lack of a single-item pain rating scale validated for the particular context. The goal of this study was to examine the face validity and cultural acceptability of two single-item pain scales, the Numerical Rating Scale (NRS) and the Faces Pain Scale-Revised (FPS-R), in a population of patients on the medical, surgical, and pediatric wards of Moi Teaching and Referral Hospital in Kenya. Methods Swahili versions of the NRS and FPS-R were developed by standard translation and back-translation. Cognitive interviews were performed with 15 patients at Moi Teaching and Referral Hospital in Eldoret, Kenya. Interview transcripts were analyzed on a question-by-question basis to identify major themes revealed through the cognitive interviewing process and to uncover any significant problems participants encountered with understanding and using the pain scales. Results Cognitive interview analysis demonstrated that participants had good comprehension of both the NRS and the FPS-R and showed rational decision-making processes in choosing their responses. Participants felt that both scales were easy to use. The FPS-R was preferred almost unanimously to the NRS. Conclusions The face validity and acceptability of the Swahili versions of the NRS and FPS-R has been demonstrated for use in Kenyan patients. The broader application of these scales should be evaluated and may benefit patients who currently suffer from pain. PMID:22512923

  13. 4D pressure MRI: validation through in-vitro experiments and simulations

    NASA Astrophysics Data System (ADS)

    Schiavazzi, Daniele; Amili, Omid; Coletti, Filippo

    2017-11-01

    Advances in MRI scan technology and recently developed acquisition sequences have led to the development of 4D flow MRI, a protocol capable of characterizing in-vivo hemodynamics in patients. Thus, the availability of phase-averaged time-resolved three-dimensional blood velocities has opened new opportunities for computing a wide spectrum of totally non-invasive hemodynamic indicators. In this regard, relative pressures play a particularly important role, as they are routinely employed in the clinic to detect cardiovascular abnormalities (e.g., in peripheral artery disease, valve stenosis, hypertension, etc.). In the first part of the talk, we discuss how the relative pressures can be robustly computed through the solution of a pressure Poisson equation and how noise in the velocities affects their estimate. Routine application of these techniques in the clinic, require however a thorough validation on multiple patients/anatomies and systematic comparisons with in-vitro and simulated representations. Thus, the second part of the talk illustrates the use of numerical simulation and in-vitro experimental protocols to validate these indicators with reference to aortic and cerebral vascular anatomies.

  14. A New Method to Cross Calibrate and Validate TOMS, SBUV/2, and SCIAMACHY Measurements

    NASA Technical Reports Server (NTRS)

    Ahmad, Ziauddin; Hilsenrath, Ernest; Einaudi, Franco (Technical Monitor)

    2001-01-01

    A unique method to validate back scattered ultraviolet (buv) type satellite data that complements the measurements from existing ground networks is proposed. The method involves comparing the zenith sky radiance measurements from the ground to the nadir radiance measurements taken from space. Since the measurements are compared directly, the proposed method is superior to any other method that involves comparing derived products (for example, ozone), because comparison of derived products involve inversion algorithms which are susceptible to several type of errors. Forward radiative transfer (RT) calculations show that for an aerosol free atmosphere, the ground-based zenith sky radiance measurement and the satellite nadir radiance measurements can be predicted with an accuracy of better than 1 percent. The RT computations also show that for certain values of the solar zenith angles, the radiance comparisons could be better than half a percent. This accuracy is practically independent of ozone amount and aerosols in the atmosphere. Experiences with the Shuttle Solar Backscatter Ultraviolet (SSBUV) program show that the accuracy of the ground-based zenith sky radiance measuring instrument can be maintained at a level of a few tenth of a percent. This implies that the zenith sky radiance measurements can be used to validate Total Ozone Mapping Spectrometer (TOMS), Solar Backscatter Ultraviolet (SBUV/2), and The SCanning Imaging Absorption SpectroMeter for Atmospheric CHartographY (SCIAMACHY) radiance data. Also, this method will help improve the long term precision of the measurements for better trend detection and the accuracy of other BUV products such as tropospheric ozone and aerosols. Finally, in the long term, this method is a good candidate to inter-calibrate and validate long term observations of upcoming operational instruments such as Global Ozone Monitoring Experiment (GOME-2), Ozone Mapping Instrument (OMI), Ozone Dynamics Ultraviolet Spectrometer (ODUS

  15. Airborne Active and Passive L-Band Observations in Soil Moisture Active Passive Validation Experiment 2012 (SMAPVEX12)

    NASA Astrophysics Data System (ADS)

    Colliander, A.; Yueh, S. H.; Chazanoff, S.; Jackson, T. J.; McNairn, H.; Bullock, P.; Wiseman, G.; Berg, A. A.; Magagi, R.; Njoku, E. G.

    2012-12-01

    NASA's (National Aeronautics and Space Administration) Soil Moisture Active Passive (SMAP) Mission is scheduled for launch in October 2014. The objective of the mission is global mapping of soil moisture and freeze/thaw state. Merging of active and passive L-band observations of the mission will enable unprecedented combination of accuracy, resolution, coverage and revisit-time for soil moisture and freeze/thaw state retrieval. For pre-launch algorithm development and validation the SMAP project and NASA coordinated a field campaign named as SMAPVEX12 (Soil Moisture Active Passive Validation Experiment 2012) together with Agriculture and Agri-Food Canada in the vicinity of Winnipeg, Canada in June-July, 2012. The main objective of SMAPVEX12 was acquisition of data record that features long-time series with varying soil moisture and vegetation conditions (for testing the application of time-series approach) over aerial domain of multiple parallel lines (for spatial disaggregation studies). The coincident active and passive L-band data were acquired using the Passive Active L-band System (PALS), which is an airborne radiometer and radar developed for testing L-band retrieval algorithms. For SMAPVEX12 PALS was installed on a Twin Otter aircraft. The flight plan included flights at two altitudes. The higher altitude was used to map the whole experiment domain and the lower altitude was used to obtain measurements over a specific set of field sites. The spatial resolution (and swath) of the radar and radiometer from low altitude was about 600 m and from high altitude about 1500 m. The PALS acquisitions were complemented with high resolution (~10 m) L-band SAR measurements carried out by UAVSAR instrument on-board G-III aircraft. The campaign ran from June 7 until July 19. The PALS instrument conducted 17 brightness temperature and backscatter measurement flights and the UAVSAR conducted 14 backscatter measurement flights. The airborne data acquisition was supported by

  16. THE VALIDITY OF HUMAN AND COMPUTERIZED WRITING ASSESSMENT

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Ronald L. Boring

    2005-09-01

    This paper summarizes an experiment designed to assess the validity of essay grading between holistic and analytic human graders and a computerized grader based on latent semantic analysis. The validity of the grade was gauged by the extent to which the student’s knowledge of the topic correlated with the grader’s expert knowledge. To assess knowledge, Pathfinder networks were generated by the student essay writers, the holistic and analytic graders, and the computerized grader. It was found that the computer generated grades more closely matched the definition of valid grading than did human generated grades.

  17. Fundamentals of endoscopic surgery: creation and validation of the hands-on test.

    PubMed

    Vassiliou, Melina C; Dunkin, Brian J; Fried, Gerald M; Mellinger, John D; Trus, Thadeus; Kaneva, Pepa; Lyons, Calvin; Korndorffer, James R; Ujiki, Michael; Velanovich, Vic; Kochman, Michael L; Tsuda, Shawn; Martinez, Jose; Scott, Daniel J; Korus, Gary; Park, Adrian; Marks, Jeffrey M

    2014-03-01

    The Fundamentals of Endoscopic Surgery™ (FES) program consists of online materials and didactic and skills-based tests. All components were designed to measure the skills and knowledge required to perform safe flexible endoscopy. The purpose of this multicenter study was to evaluate the reliability and validity of the hands-on component of the FES examination, and to establish the pass score. Expert endoscopists identified the critical skill set required for flexible endoscopy. They were then modeled in a virtual reality simulator (GI Mentor™ II, Simbionix™ Ltd., Airport City, Israel) to create five tasks and metrics. Scores were designed to measure both speed and precision. Validity evidence was assessed by correlating performance with self-reported endoscopic experience (surgeons and gastroenterologists [GIs]). Internal consistency of each test task was assessed using Cronbach's alpha. Test-retest reliability was determined by having the same participant perform the test a second time and comparing their scores. Passing scores were determined by a contrasting groups methodology and use of receiver operating characteristic curves. A total of 160 participants (17 % GIs) performed the simulator test. Scores on the five tasks showed good internal consistency reliability and all had significant correlations with endoscopic experience. Total FES scores correlated 0.73, with participants' level of endoscopic experience providing evidence of their validity, and their internal consistency reliability (Cronbach's alpha) was 0.82. Test-retest reliability was assessed in 11 participants, and the intraclass correlation was 0.85. The passing score was determined and is estimated to have a sensitivity (true positive rate) of 0.81 and a 1-specificity (false positive rate) of 0.21. The FES hands-on skills test examines the basic procedural components required to perform safe flexible endoscopy. It meets rigorous standards of reliability and validity required for high

  18. Validation of TGLF in C-Mod and DIII-D using machine learning and integrated modeling tools

    NASA Astrophysics Data System (ADS)

    Rodriguez-Fernandez, P.; White, Ae; Cao, Nm; Creely, Aj; Greenwald, Mj; Grierson, Ba; Howard, Nt; Meneghini, O.; Petty, Cc; Rice, Je; Sciortino, F.; Yuan, X.

    2017-10-01

    Predictive models for steady-state and perturbative transport are necessary to support burning plasma operations. A combination of machine learning algorithms and integrated modeling tools is used to validate TGLF in C-Mod and DIII-D. First, a new code suite, VITALS, is used to compare SAT1 and SAT0 models in C-Mod. VITALS exploits machine learning and optimization algorithms for the validation of transport codes. Unlike SAT0, the SAT1 saturation rule contains a model to capture cross-scale turbulence coupling. Results show that SAT1 agrees better with experiments, further confirming that multi-scale effects are needed to model heat transport in C-Mod L-modes. VITALS will next be used to analyze past data from DIII-D: L-mode ``Shortfall'' plasma and ECH swing experiments. A second code suite, PRIMA, allows for integrated modeling of the plasma response to Laser Blow-Off cold pulses. Preliminary results show that SAT1 qualitatively reproduces the propagation of cold pulses after LBO injections and SAT0 does not, indicating that cross-scale coupling effects play a role in the plasma response. PRIMA will be used to ``predict-first'' cold pulse experiments using the new LBO system at DIII-D, and analyze existing ECH heat pulse data. Work supported by DE-FC02-99ER54512, DE-FC02-04ER54698.

  19. Validation of Seasonal Forecast of Indian Summer Monsoon Rainfall

    NASA Astrophysics Data System (ADS)

    Das, Sukanta Kumar; Deb, Sanjib Kumar; Kishtawal, C. M.; Pal, Pradip Kumar

    2015-06-01

    The experimental seasonal forecast of Indian summer monsoon (ISM) rainfall during June through September using Community Atmosphere Model (CAM) version 3 has been carried out at the Space Applications Centre Ahmedabad since 2009. The forecasts, based on a number of ensemble members (ten minimum) of CAM, are generated in several phases and updated on regular basis. On completion of 5 years of experimental seasonal forecasts in operational mode, it is required that the overall validation or correctness of the forecast system is quantified and that the scope is assessed for further improvements of the forecast over time, if any. The ensemble model climatology generated by a set of 20 identical CAM simulations is considered as the model control simulation. The performance of the forecast has been evaluated by assuming the control simulation as the model reference. The forecast improvement factor shows positive improvements, with higher values for the recent forecasted years as compared to the control experiment over the Indian landmass. The Taylor diagram representation of the Pearson correlation coefficient (PCC), standard deviation and centered root mean square difference has been used to demonstrate the best PCC, in the order of 0.74-0.79, recorded for the seasonal forecast made during 2013. Further, the bias score of different phases of experiment revealed the fact that the ISM rainfall forecast is affected by overestimation in predicting the low rain-rate (less than 7 mm/day), but by underestimation in the medium and high rain-rate (higher than 11 mm/day). Overall, the analysis shows significant improvement of the ISM forecast over the last 5 years, viz. 2009-2013, due to several important modifications that have been implemented in the forecast system. The validation exercise has also pointed out a number of shortcomings in the forecast system; these will be addressed in the upcoming years of experiments to improve the quality of the ISM prediction.

  20. The Tromso Infant Faces Database (TIF): Development, Validation and Application to Assess Parenting Experience on Clarity and Intensity Ratings.

    PubMed

    Maack, Jana K; Bohne, Agnes; Nordahl, Dag; Livsdatter, Lina; Lindahl, Åsne A W; Øvervoll, Morten; Wang, Catharina E A; Pfuhl, Gerit

    2017-01-01

    Newborns and infants are highly depending on successfully communicating their needs; e.g., through crying and facial expressions. Although there is a growing interest in the mechanisms of and possible influences on the recognition of facial expressions in infants, heretofore there exists no validated database of emotional infant faces. In the present article we introduce a standardized and freely available face database containing Caucasian infant face images from 18 infants 4 to 12 months old. The development and validation of the Tromsø Infant Faces (TIF) database is presented in Study 1. Over 700 adults categorized the photographs by seven emotion categories (happy, sad, disgusted, angry, afraid, surprised, neutral) and rated intensity, clarity and their valance. In order to examine the relevance of TIF, we then present its first application in Study 2, investigating differences in emotion recognition across different stages of parenthood. We found a small gender effect in terms of women giving higher intensity and clarity ratings than men. Moreover, parents of young children rated the images as clearer than all the other groups, and parents rated "neutral" expressions as more clearly and more intense. Our results suggest that caretaking experience provides an implicit advantage in the processing of emotional expressions in infant faces, especially for the more difficult, ambiguous expressions.

  1. Modeling the effects of argument length and validity on inductive and deductive reasoning.

    PubMed

    Rotello, Caren M; Heit, Evan

    2009-09-01

    In an effort to assess models of inductive reasoning and deductive reasoning, the authors, in 3 experiments, examined the effects of argument length and logical validity on evaluation of arguments. In Experiments 1a and 1b, participants were given either induction or deduction instructions for a common set of stimuli. Two distinct effects were observed: Induction judgments were more affected by argument length, and deduction judgments were more affected by validity. In Experiment 2, fluency was manipulated by displaying the materials in a low-contrast font, leading to increased sensitivity to logical validity. Several variants of 1-process and 2-process models of reasoning were assessed against the results. A 1-process model that assumed the same scale of argument strength underlies induction and deduction was not successful. A 2-process model that assumed separate, continuous informational dimensions of apparent deductive validity and associative strength gave the more successful account. (c) 2009 APA, all rights reserved.

  2. Sns Moderator Poison Design and Experiment Validation of the Moderator Performance

    NASA Astrophysics Data System (ADS)

    Lu, W.; Iverson, E. B.; Ferguson, P. D.; Crabtree, J. A.; Gallmeier, F. X.; Remec, I.; Baxter, D. V.; Lavelle, C. M.

    2009-08-01

    The Spallation Neutron Source (SNS) at Oak Ridge National Laboratory reached 180 kW in August 2007, becoming the brightest pulsed neutron source in the world. At its full power of 1.4 MW, SNS will have thermal neutron fluxes approximately an order of magnitude greater than any existing pulsed spallation source. It thus brings a serious challenge to the lifetime of the moderator poison sheets. The SNS moderators are integrated with the inner reflector plug (IRP) at a cost of $2 million a piece. A replacement of the IRP presents a significant drawback to the facility due to the activation and the operation cost. Although there are many factors limiting the lifetime of the IRP, such as radiation damage to the structural material and helium production in beryllium, the limiting factor is the lifetime of the moderator poison sheets. The current operating target system of SNS was built with thick Gd poison sheets at a projected lifetime of 3 years. A recent design based on the MCNPX calculation proposed to replace the Gd poison sheets with even thicker Cd poison sheets, aiming to extend the poison sheet lifetime from 3 to 4 years accompanied by an approximate 5% gain of the moderator performance. An experiment was carried out to verify the calculated moderator performance at the Low Energy Neutron Source (LENS), Indiana University, where the spectra of two polyethylene moderators were measured. The moderators are Cd-decoupled and are poisoned with 0.8 mm Gd and 1.2 mm Cd, respectively. The preliminary analysis of the experiment data shows that the characteristics of the measured spectra of the Gd- and Cd-poisoned moderators agree well with what the calculation predicted. A better moderator performance is observed in the Cd-poisoned moderator. The measured ratio of Cd over Gd on the moderator performance is in a reasonable agreement with the calculation. Further investigation is underway for a better understanding of the difference between the experiment and the

  3. Intoxication-Related AmED (Alcohol Mixed with Energy Drink) Expectancies Scale: Initial Development and Validation

    PubMed Central

    Miller, Kathleen E.; Dermen, Kurt H.; Lucke, Joseph F.

    2017-01-01

    BACKGROUND Young adult use of alcohol mixed with energy drinks (AmEDs) has been linked with elevated risks for a constellation of problem behaviors. These risks may be conditioned by expectancies regarding the effects of caffeine in conjunction with alcohol consumption. The aim of this study was to describe the construction and psychometric evaluation of the Intoxication-Related AmED Expectancies Scale (AmED_EXPI), 15 self-report items measuring beliefs about how the experience of AmED intoxication differs from the experience of noncaffeinated alcohol (NCA) intoxication. METHODS Scale development and testing were conducted using data from a U.S. national sample of 3,105 adolescents and emerging adults aged 13–25. Exploratory and confirmatory factor analyses were conducted to evaluate the factor structure and establish factor invariance across gender, age, and prior experience with AmED use. Cross-sectional and longitudinal analyses examining correlates of AmED use were used to assess construct and predictive validity. RESULTS In confirmatory factor analyses, fit indices for the hypothesized four-factor structure (i.e., Intoxication Management [IM], Alertness [AL], Sociability [SO], and Jitters [JT]) revealed a moderately good fit to the data. Together, these factors accounted for 75.3% of total variance. The factor structure was stable across male/female, teen/young adult, and AmED experience/no experience subgroups. The resultant unit-weighted subscales showed strong internal consistency and satisfactory convergent validity. Baseline scores on the IM, SO, and JT subscales predicted changes in AmED use over a subsequent three-month period. CONCLUSIONS The AmED_EXPI appears to be a reliable and valid tool for measuring expectancies about the effects of caffeine during alcohol intoxication. PMID:28421613

  4. Validation of a wireless modular monitoring system for structures

    NASA Astrophysics Data System (ADS)

    Lynch, Jerome P.; Law, Kincho H.; Kiremidjian, Anne S.; Carryer, John E.; Kenny, Thomas W.; Partridge, Aaron; Sundararajan, Arvind

    2002-06-01

    A wireless sensing unit for use in a Wireless Modular Monitoring System (WiMMS) has been designed and constructed. Drawing upon advanced technological developments in the areas of wireless communications, low-power microprocessors and micro-electro mechanical system (MEMS) sensing transducers, the wireless sensing unit represents a high-performance yet low-cost solution to monitoring the short-term and long-term performance of structures. A sophisticated reduced instruction set computer (RISC) microcontroller is placed at the core of the unit to accommodate on-board computations, measurement filtering and data interrogation algorithms. The functionality of the wireless sensing unit is validated through various experiments involving multiple sensing transducers interfaced to the sensing unit. In particular, MEMS-based accelerometers are used as the primary sensing transducer in this study's validation experiments. A five degree of freedom scaled test structure mounted upon a shaking table is employed for system validation.

  5. The Teenage Nonviolence Test: Concurrent and Discriminant Validity.

    ERIC Educational Resources Information Center

    Konen, Kristopher; Mayton, Daniel M., II; Delva, Zenita; Sonnen, Melinda; Dahl, William; Montgomery, Richard

    This study was designed to document the validity of the Teenage Nonviolence Test (TNT). In this study the concurrent validity of the TNT in various ways, the validity of the TNT using known groups, and the discriminant validity of the TNT by evaluating its relationships with other psychological constructs were assessed. The results showed that the…

  6. Approaching the investigation of plasma turbulence through a rigorous verification and validation procedure: A practical example

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Ricci, P., E-mail: paolo.ricci@epfl.ch; Riva, F.; Theiler, C.

    In the present work, a Verification and Validation procedure is presented and applied showing, through a practical example, how it can contribute to advancing our physics understanding of plasma turbulence. Bridging the gap between plasma physics and other scientific domains, in particular, the computational fluid dynamics community, a rigorous methodology for the verification of a plasma simulation code is presented, based on the method of manufactured solutions. This methodology assesses that the model equations are correctly solved, within the order of accuracy of the numerical scheme. The technique to carry out a solution verification is described to provide a rigorousmore » estimate of the uncertainty affecting the numerical results. A methodology for plasma turbulence code validation is also discussed, focusing on quantitative assessment of the agreement between experiments and simulations. The Verification and Validation methodology is then applied to the study of plasma turbulence in the basic plasma physics experiment TORPEX [Fasoli et al., Phys. Plasmas 13, 055902 (2006)], considering both two-dimensional and three-dimensional simulations carried out with the GBS code [Ricci et al., Plasma Phys. Controlled Fusion 54, 124047 (2012)]. The validation procedure allows progress in the understanding of the turbulent dynamics in TORPEX, by pinpointing the presence of a turbulent regime transition, due to the competition between the resistive and ideal interchange instabilities.« less

  7. A Framework for Understanding Experiments

    DTIC Science & Technology

    2008-06-01

    operations. Experiments that emphasize free play and uncertainty in scenarios reflect conditions found in existent operations and satisfy external...validity Requirement 4, the ability to relate results. Conversely, experiments emphasizing similar conditions with diminished free play across multiple

  8. Development and validation of a critical gradient energetic particle driven Alfven eigenmode transport model for DIII-D tilted neutral beam experiments

    DOE PAGES

    Waltz, Ronald E.; Bass, Eric M.; Heidbrink, William W.; ...

    2015-10-30

    Recent experiments with the DIII-D tilted neutral beam injection (NBI) varying the beam energetic particle (EP) source profiles have provided strong evidence that unstable Alfven eigenmodes (AE) drive stiff EP transport at a critical EP density gradient. Here the critical gradient is identified by the local AE growth rate being equal to the local ITG/TEM growth rate at the same low toroidal mode number. The growth rates are taken from the gyrokinetic code GYRO. Simulation show that the slowing down beam-like EP distribution has a slightly lower critical gradient than the Maxwellian. The ALPHA EP density transport code, used tomore » validate the model, combines the low-n stiff EP critical density gradient AE mid-core transport with the energy independent high-n ITG/TEM density transport model controling the central core EP density profile. For the on-axis NBI heated DIII-D shot 146102, while the net loss to the edge is small, about half the birth fast ions are transported from the central core r/a < 0.5 and the central density is about half the slowing down density. Lastly, these results are in good agreement with experimental fast ion pressure profiles inferred from MSE constrained EFIT equilibria.« less

  9. A tool for assessing the quality of nursing handovers: a validation study.

    PubMed

    Ferrara, Paolo; Terzoni, Stefano; Davì, Salvatore; Bisesti, Alberto; Destrebecq, Anne

    2017-08-10

    Handover, in particular between two shifts, is a crucial aspect of nursing for patient safety, aimed at ensuring continuity of care. During this process, several factors can affect quality of care and cause errors. This study aimed to assess quality of handovers, by validating the Handoff CEX-Italian scale. The scale was translated from English into Italian and the content validity index was calculated and internal consistency assessed. The scale was used in several units of the San Paolo Teaching Hospital in Milan, Italy. A total of 48 reports were assessed (192 evaluations). The median score was 6, interquartile range (IQR) [5;7] and was not influenced by specific (p=0.21) or overall working experience (p=0.13). The domains showing the lowest median values (median=6, IQR [4;8]) were context, communication, and organisation. Night to morning handovers obtained the lowest scores. CVI-S was 0.96, Cronbach's alpha was 0.79. The Handoff CEX-Italian scale is valid and reliable and it can be used to assess the quality of nurse handovers.

  10. Validating a Geographical Image Retrieval System.

    ERIC Educational Resources Information Center

    Zhu, Bin; Chen, Hsinchun

    2000-01-01

    Summarizes a prototype geographical image retrieval system that demonstrates how to integrate image processing and information analysis techniques to support large-scale content-based image retrieval. Describes an experiment to validate the performance of this image retrieval system against that of human subjects by examining similarity analysis…

  11. Measurements of Humidity in the Atmosphere and Validation Experiments (Mohave, Mohave II): Results Overview

    NASA Technical Reports Server (NTRS)

    Leblanc, Thierry; McDermid, Iain S.; McGee, Thomas G.; Twigg, Laurence W.; Sumnicht, Grant K.; Whiteman, David N.; Rush, Kurt D.; Cadirola, Martin P.; Venable, Demetrius D.; Connell, R.; hide

    2008-01-01

    The Measurements of Humidity in the Atmosphere and Validation Experiments (MOHAVE, MOHAVE-II) inter-comparison campaigns took place at the Jet Propulsion Laboratory (JPL) Table Mountain Facility (TMF, 34.5(sup o)N) in October 2006 and 2007 respectively. Both campaigns aimed at evaluating the capability of three Raman lidars for the measurement of water vapor in the upper troposphere and lower stratosphere (UT/LS). During each campaign, more than 200 hours of lidar measurements were compared to balloon borne measurements obtained from 10 Cryogenic Frost-point Hygrometer (CFH) flights and over 50 Vaisala RS92 radiosonde flights. During MOHAVE, fluorescence in all three lidar receivers was identified, causing a significant wet bias above 10-12 km in the lidar profiles as compared to the CFH. All three lidars were reconfigured after MOHAVE, and no such bias was observed during the MOHAVE-II campaign. The lidar profiles agreed very well with the CFH up to 13-17 km altitude, where the lidar measurements become noise limited. The results from MOHAVE-II have shown that the water vapor Raman lidar will be an appropriate technique for the long-term monitoring of water vapor in the UT/LS given a slight increase in its power-aperture, as well as careful calibration.

  12. Ego-Dissolution and Psychedelics: Validation of the Ego-Dissolution Inventory (EDI).

    PubMed

    Nour, Matthew M; Evans, Lisa; Nutt, David; Carhart-Harris, Robin L

    2016-01-01

    The experience of a compromised sense of "self", termed ego-dissolution, is a key feature of the psychedelic experience. This study aimed to validate the Ego-Dissolution Inventory (EDI), a new 8-item self-report scale designed to measure ego-dissolution. Additionally, we aimed to investigate the specificity of the relationship between psychedelics and ego-dissolution. Sixteen items relating to altered ego-consciousness were included in an internet questionnaire; eight relating to the experience of ego-dissolution (comprising the EDI), and eight relating to the antithetical experience of increased self-assuredness, termed ego-inflation. Items were rated using a visual analog scale. Participants answered the questionnaire for experiences with classical psychedelic drugs, cocaine and/or alcohol. They also answered the seven questions from the Mystical Experiences Questionnaire (MEQ) relating to the experience of unity with one's surroundings. Six hundred and ninety-one participants completed the questionnaire, providing data for 1828 drug experiences (1043 psychedelics, 377 cocaine, 408 alcohol). Exploratory factor analysis demonstrated that the eight EDI items loaded exclusively onto a single common factor, which was orthogonal to a second factor comprised of the items relating to ego-inflation (rho = -0.110), demonstrating discriminant validity. The EDI correlated strongly with the MEQ-derived measure of unitive experience (rho = 0.735), demonstrating convergent validity. EDI internal consistency was excellent (Cronbach's alpha 0.93). Three analyses confirmed the specificity of ego-dissolution for experiences occasioned by psychedelic drugs. Firstly, EDI score correlated with drug-dose for psychedelic drugs (rho = 0.371), but not for cocaine (rho = 0.115) or alcohol (rho = -0.055). Secondly, the linear regression line relating the subjective intensity of the experience to ego-dissolution was significantly steeper for psychedelics (unstandardized regression

  13. Ego-Dissolution and Psychedelics: Validation of the Ego-Dissolution Inventory (EDI)

    PubMed Central

    Nour, Matthew M.; Evans, Lisa; Nutt, David; Carhart-Harris, Robin L.

    2016-01-01

    Aims: The experience of a compromised sense of “self”, termed ego-dissolution, is a key feature of the psychedelic experience. This study aimed to validate the Ego-Dissolution Inventory (EDI), a new 8-item self-report scale designed to measure ego-dissolution. Additionally, we aimed to investigate the specificity of the relationship between psychedelics and ego-dissolution. Method: Sixteen items relating to altered ego-consciousness were included in an internet questionnaire; eight relating to the experience of ego-dissolution (comprising the EDI), and eight relating to the antithetical experience of increased self-assuredness, termed ego-inflation. Items were rated using a visual analog scale. Participants answered the questionnaire for experiences with classical psychedelic drugs, cocaine and/or alcohol. They also answered the seven questions from the Mystical Experiences Questionnaire (MEQ) relating to the experience of unity with one’s surroundings. Results: Six hundred and ninety-one participants completed the questionnaire, providing data for 1828 drug experiences (1043 psychedelics, 377 cocaine, 408 alcohol). Exploratory factor analysis demonstrated that the eight EDI items loaded exclusively onto a single common factor, which was orthogonal to a second factor comprised of the items relating to ego-inflation (rho = −0.110), demonstrating discriminant validity. The EDI correlated strongly with the MEQ-derived measure of unitive experience (rho = 0.735), demonstrating convergent validity. EDI internal consistency was excellent (Cronbach’s alpha 0.93). Three analyses confirmed the specificity of ego-dissolution for experiences occasioned by psychedelic drugs. Firstly, EDI score correlated with drug-dose for psychedelic drugs (rho = 0.371), but not for cocaine (rho = 0.115) or alcohol (rho = −0.055). Secondly, the linear regression line relating the subjective intensity of the experience to ego-dissolution was significantly steeper for psychedelics

  14. [Comparative study of the subjective emotional experience among adolescents showing depressive symptoms associated or not with risk-taking behavior].

    PubMed

    Bréjard, V; Pasquier, A; Bonnet, A; Pedinielli, J-L

    2011-09-01

    Relationships between risk-taking behavior and depressive disorders in young people are considered as a complex psychopathological problem. Previous findings showed strong correlations between substance abuse, risk-taking behavior and depressive symptoms. Nevertheless, questions remain concerning potential common factors of depression and risk-taking behavior. Besides research focusing on personality dimensions, some others highlight the role played by emotions and their pathological aspects. In these studies, pathological emotional processing such as alexithymia or specific deficit in emotional intensity was linked to both risk-taking behavior and depressive disorders. The aim of this study was to investigate potential specific emotional profiles of adolescents engaged in pathological risk-taking or depressive symptomatology, versus adolescents presenting an association of both. Four hundred and eigty-eight adolescents (m(age)=14,93, SD=1,44), with 257 boys (m(age)=15, SD=1,51) and 231 girls (m(age)=14,52, SD=1,23), were spread into four groups: adolescents engaged in high level risk-taking, adolescents showing both high risk-taking and high depressive symptoms, depressed adolescents, and a control group without any pathological aspects. The four groups completed a set of three assessments: Youth Risk Behavior Surveillance Scale (YRBSS), Level of Emotional Awareness Scale (LEAS) and Differential Emotional Scale (DES). Adolescents engaged in risk-taking have the lowest level of emotional awareness and subjective emotional intensity, while adolescents of the second group (depression with risk-taking behavior) have a higher level on both measures. Depressed adolescents present the highest score of emotional awareness within the pathological groups, lower than controls. Paradoxically, their ability to represent themselves others' emotions were higher than the control group, just as the intensity of their subjective emotional experience in case of negative emotions

  15. Estimation and Validation of Oceanic Mass Circulation from the GRACE Mission

    NASA Technical Reports Server (NTRS)

    Boy, J.-P.; Rowlands, D. D.; Sabaka, T. J.; Luthcke, S. B.; Lemoine, F. G.

    2011-01-01

    Since the launch of the Gravity Recovery And Climate Experiment (GRACE) in March 2002, the Earth's surface mass variations have been monitored with unprecedented accuracy and resolution. Compared to the classical spherical harmonic solutions, global high-resolution mascon solutions allows the retrieval of mass variations with higher spatial and temporal sampling (2 degrees and 10 days). We present here the validation of the GRACE global mascon solutions by comparing mass estimates to a set of about 100 ocean bottom pressure (OSP) records, and show that the forward modelling of continental hydrology prior to the inversion of the K-band range rate data allows better estimates of ocean mass variations. We also validate our GRACE results to OSP variations modelled by different state-of-the-art ocean general circulation models, including ECCO (Estimating the Circulation and Climate of the Ocean) and operational and reanalysis from the MERCATOR project.

  16. Measuring Dispositional Flow: Validity and reliability of the Dispositional Flow State Scale 2, Italian version.

    PubMed

    Riva, Eleonora F M; Riva, Giuseppe; Talò, Cosimo; Boffi, Marco; Rainisio, Nicola; Pola, Linda; Diana, Barbara; Villani, Daniela; Argenton, Luca; Inghilleri, Paolo

    2017-01-01

    The aim of this study is to evaluate the psychometric properties of the Italian version of the Dispositional Flow Scale-2 (DFS-2), for use with Italian adults, young adults and adolescents. In accordance with the guidelines for test adaptation, the scale has been translated with the method of back translation. The understanding of the item has been checked according to the latest standards on the culturally sensitive translation. The scale thus produced was administered to 843 individuals (of which 60.69% female), between the ages of 15 and 74. The sample is balanced between workers and students. The main activities defined by the subjects allow the sample to be divided into three categories: students, workers, athletes (professionals and semi-professionals). The confirmatory factor analysis, conducted using the Maximum Likelihood Estimator (MLM), showed acceptable fit indexes. Reliability and validity have been verified, and structural invariance has been verified on 6 categories of Flow experience and for 3 subsamples with different with different fields of action. Correlational analysis shows significant high values between the nine dimensions. Our data confirmed the validity and reliability of the Italian DFS-2 in measuring Flow experiences. The scale is reliable for use with Italian adults, young adults and adolescents. The Italian version of the scale is suitable for the evaluation of the subjective tendency to experience Flow trait characteristic in different contest, as sport, study and work.

  17. Longitudinal Measurement Equivalence of Subjective Language Brokering Experiences Scale in Mexican American Adolescents

    PubMed Central

    Kim, Su Yeong; Hou, Yang; Shen, Yishan; Zhang, Minyu

    2016-01-01

    Objectives Language brokering occurs frequently in immigrant families and can have significant implications for the well-being of family members involved. The present study aimed to develop and validate a measure that can be used to assess multiple dimensions of subjective language brokering experiences among Mexican American adolescents. Methods Participants were 557 adolescent language brokers (54.2% female, Mage.wave1 =12.96, SD=.94) in Mexican American families. Results Using exploratory and confirmatory factor analyses, we were able to identify seven reliable subscales of language brokering: linguistic benefits, socio-emotional benefits, efficacy, positive parent-child relationships, parental dependence, negative feelings, and centrality. Tests of factorial invariance show that these subscales demonstrate, at minimum, partial strict invariance across time and across experiences of translating for mothers and fathers, and in most cases, also across adolescent gender, nativity, and translation frequency. Thus, in general, the means of the subscales and the relations among the subscales with other variables can be compared across these different occasions and groups. Tests of criterion-related validity demonstrated that these subscales correlated, concurrently and longitudinally, with parental warmth and hostility, parent-child alienation, adolescent family obligation, depressive symptoms, resilience, and life meaning. Conclusions This reliable and valid subjective language brokering experiences scale will be helpful for gaining a better understanding of adolescents’ language brokering experiences with their mothers and fathers, and how such experiences may influence their development. PMID:27362872

  18. Development and validation of the Alcohol Myopia Scale.

    PubMed

    Lac, Andrew; Berger, Dale E

    2013-09-01

    Alcohol myopia theory conceptualizes the ability of alcohol to narrow attention and how this demand on mental resources produces the impairments of self-inflation, relief, and excess. The current research was designed to develop and validate a scale based on this framework. People who were alcohol users rated items representing myopic experiences arising from drinking episodes in the past month. In Study 1 (N = 260), the preliminary 3-factor structure was supported by exploratory factor analysis. In Study 2 (N = 289), the 3-factor structure was substantiated with confirmatory factor analysis, and it was superior in fit to an empirically indefensible 1-factor structure. The final 14-item scale was evaluated with internal consistency reliability, discriminant validity, convergent validity, criterion validity, and incremental validity. The alcohol myopia scale (AMS) illuminates conceptual underpinnings of this theory and yields insights for understanding the tunnel vision that arises from intoxication.

  19. Multiphysics Simulation of Low-Amplitude Acoustic Wave Detection by Piezoelectric Wafer Active Sensors Validated by In-Situ AE-Fatigue Experiment

    PubMed Central

    Giurgiutiu, Victor

    2017-01-01

    Piezoelectric wafer active sensors (PWAS) are commonly used for detecting Lamb waves for structural health monitoring application. However, in most applications of active sensing, the signals are of high-amplitude and easy to detect. In this article, we have shown a new avenue of using the PWAS transducer for detecting the low-amplitude fatigue-crack related acoustic emission (AE) signals. Multiphysics finite element (FE) simulations were performed with two PWAS transducers bonded to the structure. Various configurations of the sensors were studied by using the simulations. One PWAS was placed near to the fatigue-crack and the other one was placed at a certain distance from the crack. The simulated AE event was generated at the crack tip. The simulation results showed that both PWAS transducers were capable of sensing the AE signals. To validate the multiphysics simulation results, an in-situ AE-fatigue experiment was performed. Two PWAS transducers were bonded to the thin aerospace test coupon. The fatigue crack was generated in the test coupon which had produced low-amplitude acoustic waves. The low-amplitude fatigue-crack related AE signals were successfully captured by the PWAS transducers. The distance effect on the captured AE signals was also studied. It has been shown that some high-frequency contents of the AE signal have developed as they travel away from the crack. PMID:28817081

  20. Assessment of validity with polytrauma Veteran populations.

    PubMed

    Bush, Shane S; Bass, Carmela

    2015-01-01

    Veterans with polytrauma have suffered injuries to multiple body parts and organs systems, including the brain. The injuries can generate a triad of physical, neurologic/cognitive, and emotional symptoms. Accurate diagnosis is essential for the treatment of these conditions and for fair allocation of benefits. To accurately diagnose polytrauma disorders and their related problems, clinicians take into account the validity of reported history and symptoms, as well as clinical presentations. The purpose of this article is to describe the assessment of validity with polytrauma Veteran populations. Review of scholarly and other relevant literature and clinical experience are utilized. A multimethod approach to validity assessment that includes objective, standardized measures increases the confidence that can be placed in the accuracy of self-reported symptoms and physical, cognitive, and emotional test results. Due to the multivariate nature of polytrauma and the multiple disciplines that play a role in diagnosis and treatment, an ideal model of validity assessment with polytrauma Veteran populations utilizes neurocognitive, neurological, neuropsychiatric, and behavioral measures of validity. An overview of these validity assessment approaches as applied to polytrauma Veteran populations is presented. Veterans, the VA, and society are best served when accurate diagnoses are made.

  1. Characterization of psychotic experiences in adolescence using the specific psychotic experiences questionnaire: findings from a study of 5000 16-year-old twins.

    PubMed

    Ronald, Angelica; Sieradzka, Dominika; Cardno, Alastair G; Haworth, Claire M A; McGuire, Philip; Freeman, Daniel

    2014-07-01

    We aimed to characterize multiple psychotic experiences, each assessed on a spectrum of severity (ie, quantitatively), in a general population sample of adolescents. Over five thousand 16-year-old twins and their parents completed the newly devised Specific Psychotic Experiences Questionnaire (SPEQ); a subsample repeated it approximately 9 months later. SPEQ was investigated in terms of factor structure, intersubscale correlations, frequency of endorsement and reported distress, reliability and validity, associations with traits of anxiety, depression and personality, and sex differences. Principal component analysis revealed a 6-component solution: paranoia, hallucinations, cognitive disorganization, grandiosity, anhedonia, and parent-rated negative symptoms. These components formed the basis of 6 subscales. Correlations between different experiences were low to moderate. All SPEQ subscales, except Grandiosity, correlated significantly with traits of anxiety, depression, and neuroticism. Scales showed good internal consistency, test-retest reliability, and convergent validity. Girls endorsed more paranoia, hallucinations, and cognitive disorganization; boys reported more grandiosity and anhedonia and had more parent-rated negative symptoms. As in adults at high risk for psychosis and with psychotic disorders, psychotic experiences in adolescents are characterized by multiple components. The study of psychotic experiences as distinct dimensional quantitative traits is likely to prove an important strategy for future research, and the SPEQ is a self- and parent-report questionnaire battery that embodies this approach. © The Author 2013. Published by Oxford University Press on behalf of the Maryland Psychiatric Research Center.

  2. The Challenging Experience Questionnaire: Characterization of challenging experiences with psilocybin mushrooms

    PubMed Central

    Barrett, Frederick S.; Bradstreet, Matthew P.; Leoutsakos, Jeannie-Marie S.; Johnson, Matthew W.; Griffiths, Roland R.

    2017-01-01

    Acute adverse psychological reactions to classic hallucinogens (“bad trips”, or “challenging experiences”), while usually benign with proper screening, preparation, and support in controlled settings, remain a safety concern in uncontrolled settings (such as illicit use contexts). Anecdotal and case reports suggest potential adverse acute symptoms including affective (panic, depressed mood), cognitive (confusion, feelings of losing sanity), and somatic (nausea, heart palpitation) symptoms. Responses to items from several hallucinogen-sensitive questionnaires (Hallucinogen Rating Scale, the States of Consciousness Questionnaire, and the 5-Dimensional Altered States of Consciousness questionnaire) in an internet survey of challenging experiences with the classic hallucinogen psilocybin were used to construct and validate a Challenging Experience Questionnaire (CEQ). The stand-alone CEQ was then validated in a separate sample. Seven CEQ factors (grief, fear, death, insanity, isolation, physical distress, and paranoia) provide a phenomenological profile of challenging aspects of experiences with psilocybin. Factor scores were associated with the difficulty, meaningfulness, spiritual significance, and change in well-being attributed to the challenging experiences. The factor structure did not differ based on gender or prior struggle with anxiety or depression. The CEQ provides a basis for future investigation of predictors and outcomes of challenging experiences with psilocybin, and should be explored as a measure of challenging experiences with the broad class of classic hallucinogens. PMID:27856683

  3. Threats to the Internal Validity of Experimental and Quasi-Experimental Research in Healthcare.

    PubMed

    Flannelly, Kevin J; Flannelly, Laura T; Jankowski, Katherine R B

    2018-01-01

    The article defines, describes, and discusses the seven threats to the internal validity of experiments discussed by Donald T. Campbell in his classic 1957 article: history, maturation, testing, instrument decay, statistical regression, selection, and mortality. These concepts are said to be threats to the internal validity of experiments because they pose alternate explanations for the apparent causal relationship between the independent variable and dependent variable of an experiment if they are not adequately controlled. A series of simple diagrams illustrate three pre-experimental designs and three true experimental designs discussed by Campbell in 1957 and several quasi-experimental designs described in his book written with Julian C. Stanley in 1966. The current article explains why each design controls for or fails to control for these seven threats to internal validity.

  4. Predeployment validation of fault-tolerant systems through software-implemented fault insertion

    NASA Technical Reports Server (NTRS)

    Czeck, Edward W.; Siewiorek, Daniel P.; Segall, Zary Z.

    1989-01-01

    Fault injection-based automated testing (FIAT) environment, which can be used to experimentally characterize and evaluate distributed realtime systems under fault-free and faulted conditions is described. A survey is presented of validation methodologies. The need for fault insertion based on validation methodologies is demonstrated. The origins and models of faults, and motivation for the FIAT concept are reviewed. FIAT employs a validation methodology which builds confidence in the system through first providing a baseline of fault-free performance data and then characterizing the behavior of the system with faults present. Fault insertion is accomplished through software and allows faults or the manifestation of faults to be inserted by either seeding faults into memory or triggering error detection mechanisms. FIAT is capable of emulating a variety of fault-tolerant strategies and architectures, can monitor system activity, and can automatically orchestrate experiments involving insertion of faults. There is a common system interface which allows ease of use to decrease experiment development and run time. Fault models chosen for experiments on FIAT have generated system responses which parallel those observed in real systems under faulty conditions. These capabilities are shown by two example experiments each using a different fault-tolerance strategy.

  5. Validation of the factor structure of the adolescent dissociative experiences scale in a sample of trauma-exposed detained youth.

    PubMed

    Kerig, Patricia K; Charak, Ruby; Chaplo, Shannon D; Bennett, Diana C; Armour, Cherie; Modrowski, Crosby A; McGee, Andrew B

    2016-09-01

    The inclusion of a dissociative subtype in the Diagnostic and Statistical Manual of Mental Disorders (5th ed.; DSM–5 ) criteria for the diagnosis of posttraumatic stress disorder (PTSD) has highlighted the need for valid and reliable measures of dissociative symptoms across developmental periods. The Adolescent Dissociative Experiences Scale (A-DES) is 1 of the few measures validated for young persons, but previous studies have yielded inconsistent results regarding its factor structure. Further, research to date on the A-DES has been based upon nonclinical samples of youth or those without a known history of trauma. To address these gaps in the literature, the present study investigated the factor structure and construct validity of the A-DES in a sample of highly trauma-exposed youth involved in the juvenile justice system. A sample of 784 youth (73.7% boys) recruited from a detention center completed self-report measures of trauma exposure and the A-DES, a subset of whom (n = 212) also completed a measure of PTSD symptoms. Confirmatory factor analyses revealed a best fitting 3-factor structure comprised of depersonalization or derealization, amnesia, and loss of conscious control, with configural and metric invariance across gender. Logistic regression analyses indicated that the depersonalization or derealization factor effectively distinguished between those youth who did and did not likely meet criteria for a diagnosis of PTSD as well as those with PTSD who did and did not likely meet criteria for the dissociative subtype. These results provide support for the multidimensionality of the construct of posttraumatic dissociation and contribute to the understanding of the dissociative subtype of PTSD among adolescents. (PsycINFO Database Record PsycINFO Database Record (c) 2016 APA, all rights reserved

  6. Designing and validation of a yoga-based intervention for obsessive compulsive disorder.

    PubMed

    Bhat, Shubha; Varambally, Shivarama; Karmani, Sneha; Govindaraj, Ramajayam; Gangadhar, B N

    2016-06-01

    Some yoga-based practices have been found to be useful for patients with obsessive compulsive disorder (OCD). The authors could not find a validated yoga therapy module available for OCD. This study attempted to formulate a generic yoga-based intervention module for OCD. A yoga module was designed based on traditional and contemporary yoga literature. The module was sent to 10 yoga experts for content validation. The experts rated the usefulness of the practices on a scale of 1-5 (5 = extremely useful). The final version of the module was pilot-tested on patients with OCD (n = 17) for both feasibility and effect on symptoms. Eighty-eight per cent (22 out of 25) of the items in the initial module were retained, with modifications in the module as suggested by the experts along with patients' inputs and authors' experience. The module was found to be feasible and showed an improvement in symptoms of OCD on total Yale-Brown Obsessive-Compulsive Scale (YBOCS) score (p = 0.001). A generic yoga therapy module for OCD was validated by experts in the field and found feasible to practice in patients. A decrease in the symptom scores was also found following yoga practice of 2 weeks. Further clinical validation is warranted to confirm efficacy.

  7. Validity of self-reported exposure to shift work.

    PubMed

    Härmä, Mikko; Koskinen, Aki; Ropponen, Annina; Puttonen, Sampsa; Karhula, Kati; Vahtera, Jussi; Kivimäki, Mika

    2017-03-01

    To evaluate the validity of widely used questionnaire items on work schedule using objective registry data as reference. A cohort study of hospital employees who responded to a self-administered questionnaire on work schedule in 2008, 2012 and 2014 and were linked to individual-level pay-roll-based records on work shifts. For predictive validity, leisure-time fatigue was assessed. According to the survey data in 2014 (n=8896), 55% of the day workers had at least 1 year of earlier shift work experience. 8% of the night shift workers changed to day work during the follow-up. Using pay-roll data as reference, questions on 'shift work with night shifts' and 'permanent night work' showed high sensitivity (96% and 90%) and specificity (92% and 97%). Self-reported 'regular day work' showed moderate sensitivity (73%), but high specificity (99%) and 'shift work without night shifts' showed low sensitivity (62%) and moderate specificity (87%). In multivariate logistic regression analysis, the age-adjusted, sex-adjusted and baseline fatigue-adjusted association between 'shift work without night shifts' and leisure-time fatigue was lower for self-reported compared with objective assessment (1.30, 95% CI 0.94 to 1.82, n=1707 vs 1.89, 95% CI 1.06 to 3.39, n=1627). In contrast, shift work with night shifts, compared with permanent day work, was similarly associated with fatigue in the two assessments (2.04, 95% CI 1.62 to 2.57, n=2311 vs 1.82, 95% CI 1.28 to 2.58, n=1804). The validity of self-reported assessment of shift work varies between work schedules. Exposure misclassification in self-reported data may contribute to bias towards the null in shift work without night shifts. Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://www.bmj.com/company/products-services/rights-and-licensing/.

  8. U.S. Civil Air Show Crashes, 1993 to 2013

    PubMed Central

    Ballard, Sarah-Blythe; Osorio, Victor B.

    2016-01-01

    This study provides new public health data about U.S. civil air shows. Risk factors for fatalities in civil air show crashes were analyzed. The value of the FIA score in predicting fatal outcomes was evaluated. With the use of the FAA’s General Aviation and Air Taxi Survey and the National Transportation Safety Board’s data, the incidence of civil air show crashes from 1993 to 2013 was calculated. Fatality risk factors for crashes were analyzed by means of regression methods. The FIA index was validated to predict fatal outcomes by using the factors of fire, instrument conditions, and away-from-airport location, and was evaluated through receiver operating characteristic (ROC) curves. The civil air show crash rate was 31 crashes per 1,000 civil air events. Of the 174 civil air show crashes that occurred during the study period, 91 (52%) involved at least one fatality; on average, 1.1 people died per fatal crash. Fatalities were associated with four major risk factors: fire [adjusted odds ratio (AOR) = 7.1, 95% confidence interval (CI) = 2.4 to 20.6, P < .001], pilot error (AOR = 5.2, 95% CI = 1.8 to 14.5, P = .002), aerobatic flight (AOR = 3.6, 95% CI = 1.6 to 8.2, P = .002), and off-airport location (AOR = 3.4, 95% CI = 1.5 to 7.5, P = .003). The area under the FIA score’s ROC curve was 0.71 (95% CI = 0.64 to 0.78). Civil air show crashes were marked by a high risk of fatal outcomes to pilots in aerobatic performances but rare mass casualties. The FIA score was not a valid measurement of fatal risk in civil air show crashes. PMID:27773963

  9. Development and validation of a HPLC method for the assay of dapivirine in cell-based and tissue permeability experiments.

    PubMed

    das Neves, José; Sarmento, Bruno; Amiji, Mansoor; Bahia, Maria Fernanda

    2012-12-12

    Dapivirine, a non-nucleoside reverse transcriptase inhibitor, is being currently used for the development of potential anti-HIV microbicide formulations and delivery systems. A new high-performance liquid chromatography (HPLC) method with UV detection was developed for the assay of this drug in different biological matrices, namely cell lysates, receptor media from permeability experiments and homogenates of mucosal tissues. The method used a reversed-phase C18 column with a mobile phase composed of trifluoroacetic acid solution (0.1%, v/v) and acetonitrile in a gradient mode. Injection volume was 50μL and the flow rate 1mL/min. The total run time was 12min and UV detection was performed at 290nm for dapivirine and the internal standard (IS) diphenylamine. A Box-Behnken experimental design was used to study different experimental variables of the method, namely the ratio of the mobile phase components and the gradient time, and their influence in responses such as the retention factor, tailing factor, and theoretical plates for dapivirine and the IS, as well as the peak resolution between both compounds. The optimized method was further validated and its usefulness assessed for in vitro and ex vivo experiments using dapivirine or dapivirine-loaded nanoparticles. The method showed to be selective, linear, accurate and precise in the range of 0.02-1.5μg/mL. Other chromatographic parameters, namely carry-over, lower limit of quantification (0.02μg/mL), limit of detection (0.006μg/mL), recovery (equal or higher than 90.7%), and sample stability at different storage conditions, were also determined and found adequate for the intended purposes. The method was successfully used for cell uptake assays and permeability studies across cell monolayers and pig genital mucosal tissues. Overall, the proposed method provides a simple, versatile and reliable way for studying the behavior of dapivirine in different biological matrices and assessing its potential as an anti

  10. Downwelled longwave surface irradiance data from five sites for the FIRE/SRB Wisconsin Experiment from October 12 through November 2, 1986

    NASA Technical Reports Server (NTRS)

    Whitlock, Charles H.; Cox, Stephen K.; Lecroy, Stuart R.

    1990-01-01

    Tables are presented which show data from five sites in the First ISCCP (International Satellite Cloud Climatology Project) Regional Experiment (FIRE)/Surface Radiation Budget (SRB) Wisconsin experiment regional from October 12 through November 2, 1986. A discussion of intercomparison results is also included. The field experiment was conducted for the purposes of both intensive cirrus-cloud measurements and SRB algorithm validation activities.

  11. Laboratory plasma interactions experiments: Results and implications to future space systems

    NASA Technical Reports Server (NTRS)

    Leung, Philip

    1986-01-01

    The experimental results discussed show the significance of the effects caused by spacecraft plasma interactions, in particular the generation of Electromagnetic Interference. As the experimental results show, the magnitude of the adverse effects induced by Plasma Interactions (PI) will be more significant for spacecraft of the next century. Therefore, research is needed to control possible adverse effects. Several techniques to control the selected PI effects are discussed. Tests, in the form of flight experiments, are needed to validate these proposed ideas.

  12. Validation of a motor activity system by a robotically controlled vehicle and using standard reference compounds.

    PubMed

    Patterson, John P; Markgraf, Carrie G; Cirino, Maria; Bass, Alan S

    2005-01-01

    A series of experiments were undertaken to evaluate the accuracy, precision, specificity, and sensitivity of an automated, infrared photo beam-based open field motor activity system, the MotorMonitor v. 4.01, Hamilton-Kinder, LLC, for use in a good laboratory practices (GLP) Safety Pharmacology laboratory. This evaluation consisted of two phases: (1) system validation, employing known inputs using the EM-100 Controller Photo Beam Validation System, a robotically controlled vehicle representing a rodent and (2) biologic validation, employing groups of rats treated with the standard pharmacologic agents diazepam or D-amphetamine. The MotorMonitor's parameters that described the open-field activity of a subject were: basic movements, total distance, fine movements, x/y horizontal ambulations, rearing, and total rest time. These measurements were evaluated over a number of zones within each enclosure. System validation with the EM-100 Controller Photo Beam Validation System showed that all the parameters accurately and precisely measured what they were intended to measure, with the exception of fine movements and x/y ambulations. Biologic validation using the central nervous system depressant diazepam at 1, 2, or 5 mg/kg, i.p. produced the expected dose-dependent reduction in rat motor activity. In contrast, the central nervous system stimulant D-amphetamine produced the expected increases in rat motor activity at 0.1 and 1 mg/kg, i.p, demonstrating the specificity and sensitivity of the system. Taken together, these studies of the accuracy, precision, specificity, and sensitivity show the importance of both system and biologic validation in the evaluation of an automated open field motor activity system for use in a GLP compliant laboratory.

  13. Scaled experiments of explosions in cavities

    DOE PAGES

    Grun, J.; Cranch, G. A.; Lunsford, R.; ...

    2016-05-11

    Consequences of an explosion inside an air-filled cavity under the earth's surface are partly duplicated in a laboratory experiment on spatial scales 1000 smaller. The experiment measures shock pressures coupled into a block of material by an explosion inside a gas-filled cavity therein. The explosion is generated by suddenly heating a thin foil that is located near the cavity center with a short laser pulse, which turns the foil into expanding plasma, most of whose energy drives a blast wave in the cavity gas. Variables in the experiment are the cavity radius and explosion energy. Measurements and GEODYN code simulationsmore » show that shock pressuresmeasured in the block exhibit a weak dependence on scaled cavity radius up to ~25 m/kt 1/3, above which they decrease rapidly. Possible mechanisms giving rise to this behavior are described. As a result, the applicability of this work to validating codes used to simulate full-scale cavityexplosions is discussed.« less

  14. Validation Results for LEWICE 2.0. [Supplement

    NASA Technical Reports Server (NTRS)

    Wright, William B.; Rutkowski, Adam

    1999-01-01

    Two CD-ROMs contain experimental ice shapes and code prediction used for validation of LEWICE 2.0 (see NASA/CR-1999-208690, CASI ID 19990021235). The data include ice shapes for both experiment and for LEWICE, all of the input and output files for the LEWICE cases, JPG files of all plots generated, an electronic copy of the text of the validation report, and a Microsoft Excel(R) spreadsheet containing all of the quantitative measurements taken. The LEWICE source code and executable are not contained on the discs.

  15. Validation of the PASSPORT V2 training environment for arthroscopic skills.

    PubMed

    Stunt, J J; Kerkhoffs, G M M J; Horeman, T; van Dijk, C N; Tuijthof, G J M

    2016-06-01

    Virtual reality simulators used in the education of orthopaedic residents often lack realistic haptic feedback. To solve this, the (Practice Arthroscopic Surgical Skills for Perfect Operative Real-life Treatment) PASSPORT simulator was developed, which was subjected to fundamental changes: improved realism and user interface. The purpose was to demonstrate its face and construct validity. Thirty-one participants were divided into three groups having different levels of arthroscopic experience. Participants answered questions regarding general information and the outer appearance of the simulator for face validity. Construct validity was assessed with one standardized navigation task, which was timed. Face validity, educational value and user-friendliness were determined with two representative exercises and by asking participants to fill out the questionnaire. A value of 7 or greater was considered sufficient. Construct validity was demonstrated between experts and novices. Median task time for the fifth trial was 55 s (range 17-139 s) for the novices, 33 s (range 17-59 s) for the intermediates, and 26 s (range 14-52 s) for the experts. Median task times of three trials were not significantly different between the novices and intermediates, and none of the trials between intermediates and experts. Face validity, educational value and user-friendliness were perceived as sufficient (median >7). The presence of realistic tactile feedback was considered the biggest asset of the simulator. Proper preparation for arthroscopic operations will increase the quality of real-life surgery and patients' safety. The PASSPORT simulator can assist in achieving this, as it showed construct and face validity, and its physical nature offered adequate haptic feedback during training. This indicates that PASSPORT has potential to evolve as a valuable training modality.

  16. Complex terrain experiments in the New European Wind Atlas.

    PubMed

    Mann, J; Angelou, N; Arnqvist, J; Callies, D; Cantero, E; Arroyo, R Chávez; Courtney, M; Cuxart, J; Dellwik, E; Gottschall, J; Ivanell, S; Kühn, P; Lea, G; Matos, J C; Palma, J M L M; Pauscher, L; Peña, A; Rodrigo, J Sanz; Söderberg, S; Vasiljevic, N; Rodrigues, C Veiga

    2017-04-13

    The New European Wind Atlas project will create a freely accessible wind atlas covering Europe and Turkey, develop the model chain to create the atlas and perform a series of experiments on flow in many different kinds of complex terrain to validate the models. This paper describes the experiments of which some are nearly completed while others are in the planning stage. All experiments focus on the flow properties that are relevant for wind turbines, so the main focus is the mean flow and the turbulence at heights between 40 and 300 m. Also extreme winds, wind shear and veer, and diurnal and seasonal variations of the wind are of interest. Common to all the experiments is the use of Doppler lidar systems to supplement and in some cases replace completely meteorological towers. Many of the lidars will be equipped with scan heads that will allow for arbitrary scan patterns by several synchronized systems. Two pilot experiments, one in Portugal and one in Germany, show the value of using multiple synchronized, scanning lidar, both in terms of the accuracy of the measurements and the atmospheric physical processes that can be studied. The experimental data will be used for validation of atmospheric flow models and will by the end of the project be freely available.This article is part of the themed issue 'Wind energy in complex terrains'. © 2017 The Authors.

  17. Young adult e-cigarette use outcome expectancies: Validity of a revised scale and a short scale.

    PubMed

    Pokhrel, Pallav; Lam, Tony H; Pagano, Ian; Kawamoto, Crissy T; Herzog, Thaddeus A

    2018-03-01

    The revised youth e-cigarette outcome expectancies measure adds new items informed by recent qualitative research with young adult e-cigarette users, especially in the domain of positive "smoking" experience. Positive "smoking" experience represents beliefs that use of e-cigarettes provides outcomes associated with a better "smoking" alternative: for example, an alternative that is more socially approved, more suitable for indoor use, and that provides a safer means of enjoying nicotine. In addition, we tested a short, 8-item version of the measure which may be more easily incorporated into surveys. We tested the validity of the revised measure, both long and short versions, in terms of factor structure and associations of the expectancy factors with current e-cigarette use, e-cigarette use susceptibility, and e-cigarette use dependence. Participants were young adults (N=470; 65% women; mean age=20.9, SD=2.1). Results replicated the findings of the previous study as well as highlighted the importance of the added domain of positive "smoking" experience and the validity of the short scale. Furthermore, results showed that positive outcome expectancies are strongly associated with e-cigarette use dependence. The long and short versions of the revised youth e-cigarette outcome expectancies scale appear to be valid and useful for application not only among cigarette smokers and e-cigarette users but also among never smokers and never e-cigarette users. Copyright © 2017 Elsevier Ltd. All rights reserved.

  18. Remote Patron Validation: Posting a Proxy Server at the Digital Doorway.

    ERIC Educational Resources Information Center

    Webster, Peter

    2002-01-01

    Discussion of remote access to library services focuses on proxy servers as a method for remote access, based on experiences at Saint Mary's University (Halifax). Topics include Internet protocol user validation; browser-directed proxies; server software proxies; vendor alternatives for validating remote users; and Internet security issues. (LRW)

  19. Characterization of Aluminum Honeycomb and Experimentation for Model Development and Validation, Volume I: Discovery and Characterization Experiments for High-Density Aluminum Honeycomb

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Lu, Wei-Yang; Korellis, John S.; Lee, Kenneth L.

    2006-08-01

    Honeycomb is a structure that consists of two-dimensional regular arrays of open cells. High-density aluminum honeycomb has been used in weapon assemblies to mitigate shock and protect payload because of its excellent crush properties. In order to use honeycomb efficiently and to certify the payload is protected by the honeycomb under various loading conditions, a validated honeycomb crush model is required and the mechanical properties of the honeycombs need to be fully characterized. Volume I of this report documents an experimental study of the crush behavior of high-density honeycombs. Two sets of honeycombs were included in this investigation: commercial grademore » for initial exploratory experiments, and weapon grade, which satisfied B61 specifications. This investigation also includes developing proper experimental methods for crush characterization, conducting discovery experiments to explore crush behaviors for model improvement, and identifying experimental and material uncertainties.« less

  20. Three phase heat and mass transfer model for unsaturated soil freezing process: Part 2 - model validation

    NASA Astrophysics Data System (ADS)

    Zhang, Yaning; Xu, Fei; Li, Bingxi; Kim, Yong-Song; Zhao, Wenke; Xie, Gongnan; Fu, Zhongbin

    2018-04-01

    This study aims to validate the three-phase heat and mass transfer model developed in the first part (Three phase heat and mass transfer model for unsaturated soil freezing process: Part 1 - model development). Experimental results from studies and experiments were used for the validation. The results showed that the correlation coefficients for the simulated and experimental water contents at different soil depths were between 0.83 and 0.92. The correlation coefficients for the simulated and experimental liquid water contents at different soil temperatures were between 0.95 and 0.99. With these high accuracies, the developed model can be well used to predict the water contents at different soil depths and temperatures.

  1. Validation of SAM 2 and SAGE satellite

    NASA Technical Reports Server (NTRS)

    Kent, G. S.; Wang, P.-H.; Farrukh, U. O.; Yue, G. K.

    1987-01-01

    Presented are the results of a validation study of data obtained by the Stratospheric Aerosol and Gas Experiment I (SAGE I) and Stratospheric Aerosol Measurement II (SAM II) satellite experiments. The study includes the entire SAGE I data set (February 1979 - November 1981) and the first four and one-half years of SAM II data (October 1978 - February 1983). These data sets have been validated by their use in the analysis of dynamical, physical and chemical processes in the stratosphere. They have been compared with other existing data sets and the SAGE I and SAM II data sets intercompared where possible. The study has shown the data to be of great value in the study of the climatological behavior of stratospheric aerosols and ozone. Several scientific publications and user-oriented data summaries have appeared as a result of the work carried out under this contract.

  2. Development and Validation of the Work-Related Well-Being Index: Analysis of the Federal Employee Viewpoint Survey (FEVS).

    PubMed

    Eaton, Jennifer L; Mohr, David C; Hodgson, Michael J; McPhaul, Kathleen M

    2017-10-11

    To describe development and validation of the Work-Related Well-Being (WRWB) Index. Principal Components Analysis was performed using Federal Employee Viewpoint Survey (FEVS) data (N = 392,752) to extract variables representing worker well-being constructs. Confirmatory factor analysis was performed to verify factor structure. To validate the WRWB index, we used multiple regression analysis to examine relationships with burnout associated outcomes. PCA identified three positive psychology constructs: "Work Positivity", "Co-worker Relationships", and "Work Mastery". An 11 item index explaining 63.5% of variance was achieved. The structural equation model provided a very good fit to the data. Higher WRWB scores were positively associated with all 3 employee experience measures examined in regression models. The new WRWB index shows promise as a valid and widely accessible instrument to assess worker well-being.

  3. Methodology for Computational Fluid Dynamic Validation for Medical Use: Application to Intracranial Aneurysm.

    PubMed

    Paliwal, Nikhil; Damiano, Robert J; Varble, Nicole A; Tutino, Vincent M; Dou, Zhongwang; Siddiqui, Adnan H; Meng, Hui

    2017-12-01

    Computational fluid dynamics (CFD) is a promising tool to aid in clinical diagnoses of cardiovascular diseases. However, it uses assumptions that simplify the complexities of the real cardiovascular flow. Due to high-stakes in the clinical setting, it is critical to calculate the effect of these assumptions in the CFD simulation results. However, existing CFD validation approaches do not quantify error in the simulation results due to the CFD solver's modeling assumptions. Instead, they directly compare CFD simulation results against validation data. Thus, to quantify the accuracy of a CFD solver, we developed a validation methodology that calculates the CFD model error (arising from modeling assumptions). Our methodology identifies independent error sources in CFD and validation experiments, and calculates the model error by parsing out other sources of error inherent in simulation and experiments. To demonstrate the method, we simulated the flow field of a patient-specific intracranial aneurysm (IA) in the commercial CFD software star-ccm+. Particle image velocimetry (PIV) provided validation datasets for the flow field on two orthogonal planes. The average model error in the star-ccm+ solver was 5.63 ± 5.49% along the intersecting validation line of the orthogonal planes. Furthermore, we demonstrated that our validation method is superior to existing validation approaches by applying three representative existing validation techniques to our CFD and experimental dataset, and comparing the validation results. Our validation methodology offers a streamlined workflow to extract the "true" accuracy of a CFD solver.

  4. AIRS Retrieval Validation During the EAQUATE

    NASA Technical Reports Server (NTRS)

    Zhou, Daniel K.; Smith, William L.; Cuomo, Vincenzo; Taylor, Jonathan P.; Barnet, Christopher D.; DiGirolamo, Paolo; Pappalardo, Gelsomina; Larar, Allen M.; Liu, Xu; Newman, Stuart M.

    2006-01-01

    Atmospheric and surface thermodynamic parameters retrieved with advanced hyperspectral remote sensors of Earth observing satellites are critical for weather prediction and scientific research. The retrieval algorithms and retrieved parameters from satellite sounders must be validated to demonstrate the capability and accuracy of both observation and data processing systems. The European AQUA Thermodynamic Experiment (EAQUATE) was conducted mainly for validation of the Atmospheric InfraRed Sounder (AIRS) on the AQUA satellite, but also for assessment of validation systems of both ground-based and aircraft-based instruments which will be used for other satellite systems such as the Infrared Atmospheric Sounding Interferometer (IASI) on the European MetOp satellite, the Cross-track Infrared Sounder (CrIS) from the NPOESS Preparatory Project and the following NPOESS series of satellites. Detailed inter-comparisons were conducted and presented using different retrieval methodologies: measurements from airborne ultraspectral Fourier transform spectrometers, aircraft in-situ instruments, dedicated dropsondes and radiosondes, and ground based Raman Lidar, as well as from the European Center for Medium range Weather Forecasting (ECMWF) modeled thermal structures. The results of this study not only illustrate the quality of the measurements and retrieval products but also demonstrate the capability of these validation systems which are put in place to validate current and future hyperspectral sounding instruments and their scientific products.

  5. The WATERMED field experiment: validation of the AATSR LST product with in situ measurements

    NASA Astrophysics Data System (ADS)

    Noyes, E.; Soria, G.; Sobrino, J.; Remedios, J.; Llewellyn-Jones, D.; Corlett, G.

    The Advanced Along-Track Scanning Radiometer (AATSR) onboard ESA's Envisat Satellite, is the third in a series of a precision radiometers designed to measure Sea Surface Temperature (SST) with accuracies of better than ± 0.3 K (within 1-sigma limit). Since its launch in March 2001, a prototype AATSR Land Surface Temperature (LST) product has been produced for validation purposes only, with the product becoming operational from mid-2004. The (A)ATSR instrument design is unique in that it has both a nadir- and a forward-view, allowing the Earth's surface to be viewed along two different atmospheric path lengths, thus enabling an improved atmospheric correction to be made when retrieving surface temperature. It also uses an innovative and exceptionally stable on-board calibration system for its infrared channels, which, together with actively cooled detectors, gives extremely high radiometric sensitivity and precision. In this presentation, results from a comparison of the prototype LST product with ground-based measurements obtained at the WATERMED (WATer use Efficiency in natural vegetation and agricultural areas by Remote sensing in the MEDiterranean basin) field site near Marrakech, Morocco, are presented. The comparison shows that the AATSR has a positive bias of + 1.5 K, with a standard deviation of 0.7 K, indicating that the product is operating within the target specification (± 2.5 K) over the WATERMED field site. However, several anomalous validation points were observed during the analysis and we will discuss possible reasons for the occurrence of these data, including their coincidence with the presence of an Envisat blanking pulse (indicating the presence of a radar pulse at the time of AATSR pixel integration). Further investigation into this matter is required as previous investigations have always indicated that the presence of a payload radar pulse does not have any effect on (A)ATSR data quality.

  6. Validation of an Instrument to Measure Community College Student Satisfaction

    ERIC Educational Resources Information Center

    Zhai, Lijuan

    2012-01-01

    This article reports the development and validation of a survey instrument to measure community college students' satisfaction with their educational experiences. The initial survey included 95 questions addressing community college student experiences. Data were collected from 558 community college students during spring of 2001. An exploratory…

  7. Development and validation of RAYDOSE: a Geant4-based application for molecular radiotherapy

    NASA Astrophysics Data System (ADS)

    Marcatili, S.; Pettinato, C.; Daniels, S.; Lewis, G.; Edwards, P.; Fanti, S.; Spezi, E.

    2013-04-01

    We developed and validated a Monte-Carlo-based application (RAYDOSE) to generate patient-specific 3D dose maps on the basis of pre-treatment imaging studies. A CT DICOM image is used to model patient geometry, while repeated PET scans are employed to assess radionuclide kinetics and distribution at the voxel level. In this work, we describe the structure of this application and present the tests performed to validate it against reference data and experiments. We used the spheres of a NEMA phantom to calculate S values and total doses. The comparison with reference data from OLINDA/EXM showed an agreement within 2% for a sphere size above 2.8 cm diameter. A custom heterogeneous phantom composed of several layers of Perspex and lung equivalent material was used to compare TLD measurements of gamma radiation from 131I to Monte Carlo simulations. An agreement within 5% was found. RAYDOSE has been validated against reference data and experimental measurements and can be a useful multi-modality platform for treatment planning and research in MRT.

  8. Development and initial validation of primary care provider mental illness management and team-based care self-efficacy scales.

    PubMed

    Loeb, Danielle F; Crane, Lori A; Leister, Erin; Bayliss, Elizabeth A; Ludman, Evette; Binswanger, Ingrid A; Kline, Danielle M; Smith, Meredith; deGruy, Frank V; Nease, Donald E; Dickinson, L Miriam

    Develop and validate self-efficacy scales for primary care provider (PCP) mental illness management and team-based care participation. We developed three self-efficacy scales: team-based care (TBC), mental illness management (MIM), and chronic medical illness (CMI). We developed the scales using Bandura's Social Cognitive Theory as a guide. The survey instrument included items from previously validated scales on team-based care and mental illness management. We administered a mail survey to 900 randomly selected Colorado physicians. We conducted exploratory principal factor analysis with oblique rotation. We constructed self-efficacy scales and calculated standardized Cronbach's alpha coefficients to test internal consistency. We calculated correlation coefficients between the MIM and TBC scales and previously validated measures related to each scale to evaluate convergent validity. We tested correlations between the TBC and the measures expected to correlate with the MIM scale and vice versa to evaluate discriminant validity. PCPs (n=402, response rate=49%) from diverse practice settings completed surveys. Items grouped into factors as expected. Cronbach's alphas were 0.94, 0.88, and 0.83 for TBC, MIM, and CMI scales respectively. In convergent validity testing, the TBC scale was correlated as predicted with scales assessing communications strategies, attitudes toward teams, and other teamwork indicators (r=0.25 to 0.40, all statistically significant). Likewise, the MIM scale was significantly correlated with several items about knowledge and experience managing mental illness (r=0.24 to 41, all statistically significant). As expected in discriminant validity testing, the TBC scale had only very weak correlations with the mental illness knowledge and experience managing mental illness items (r=0.03 to 0.12). Likewise, the MIM scale was only weakly correlated with measures of team-based care (r=0.09 to.17). This validation study of MIM and TBC self-efficacy scales

  9. Experiments and Simulations of Exploding Aluminum Wires: Validation of ALEGRA-MHD

    DTIC Science & Technology

    2010-09-01

    ii REPORT DOCUMENTATION PAGE Form Approved OMB No. 0704-0188 Public reporting burden for this collection of information is estimated to average 1 ...currently valid OMB control number. PLEASE DO NOT RETURN YOUR FORM TO THE ABOVE ADDRESS. 1 . REPORT DATE (DD-MM-YYYY) September 2010 2. REPORT TYPE Final...List of Tables vi Acknowledgements vii 1 . Introduction 1 2. Experimental Setup 2 3. Computational Setup 5 3.1 Description of ALEGRA

  10. Validation of the Karolinska sleepiness scale against performance and EEG variables.

    PubMed

    Kaida, Kosuke; Takahashi, Masaya; Akerstedt, Torbjörn; Nakata, Akinori; Otsuka, Yasumasa; Haratani, Takashi; Fukasawa, Kenji

    2006-07-01

    The Karolinska sleepiness scale (KSS) is frequently used for evaluating subjective sleepiness. The main aim of the present study was to investigate the validity and reliability of the KSS with electroencephalographic, behavioral and other subjective indicators of sleepiness. Participants were 16 healthy females aged 33-43 (38.1+/-2.68) years. The experiment involved 8 measurement sessions per day for 3 consecutive days. Each session contained the psychomotor vigilance task (PVT), the Karolinska drowsiness test (KDT-EEG alpha & theta power), the alpha attenuation test (AAT-alpha power ratio open/closed eyes) and the KSS. Median reaction time, number of lapses, alpha and theta power density and the alpha attenuation coefficients (AAC) showed highly significant increase with increasing KSS. The same variables were also significantly correlated with KSS, with a mean value for lapses (r=0.56). The KSS was closely related to EEG and behavioral variables, indicating a high validity in measuring sleepiness. KSS ratings may be a useful proxy for EEG or behavioral indicators of sleepiness.

  11. Development and Validation of the Work-Related Well-Being Index: Analysis of the Federal Employee Viewpoint Survey.

    PubMed

    Eaton, Jennifer L; Mohr, David C; Hodgson, Michael J; McPhaul, Kathleen M

    2018-02-01

    To describe development and validation of the work-related well-being (WRWB) index. Principal components analysis was performed using Federal Employee Viewpoint Survey (FEVS) data (N = 392,752) to extract variables representing worker well-being constructs. Confirmatory factor analysis was performed to verify factor structure. To validate the WRWB index, we used multiple regression analysis to examine relationships with burnout associated outcomes. Principal Components Analysis identified three positive psychology constructs: "Work Positivity", "Co-worker Relationships", and "Work Mastery". An 11 item index explaining 63.5% of variance was achieved. The structural equation model provided a very good fit to the data. Higher WRWB scores were positively associated with all three employee experience measures examined in regression models. The new WRWB index shows promise as a valid and widely accessible instrument to assess worker well-being.

  12. Validation of the thermophysiological model by Fiala for prediction of local skin temperatures

    NASA Astrophysics Data System (ADS)

    Martínez, Natividad; Psikuta, Agnes; Kuklane, Kalev; Quesada, José Ignacio Priego; de Anda, Rosa María Cibrián Ortiz; Soriano, Pedro Pérez; Palmer, Rosario Salvador; Corberán, José Miguel; Rossi, René Michel; Annaheim, Simon

    2016-12-01

    The most complete and realistic physiological data are derived from direct measurements during human experiments; however, they present some limitations such as ethical concerns, time and cost burden. Thermophysiological models are able to predict human thermal response in a wide range of environmental conditions, but their use is limited due to lack of validation. The aim of this work was to validate the thermophysiological model by Fiala for prediction of local skin temperatures against a dedicated database containing 43 different human experiments representing a wide range of conditions. The validation was conducted based on root-mean-square deviation (rmsd) and bias. The thermophysiological model by Fiala showed a good precision when predicting core and mean skin temperature (rmsd 0.26 and 0.92 °C, respectively) and also local skin temperatures for most body sites (average rmsd for local skin temperatures 1.32 °C). However, an increased deviation of the predictions was observed for the forehead skin temperature (rmsd of 1.63 °C) and for the thigh during exercising exposures (rmsd of 1.41 °C). Possible reasons for the observed deviations are lack of information on measurement circumstances (hair, head coverage interference) or an overestimation of the sweat evaporative cooling capacity for the head and thigh, respectively. This work has highlighted the importance of collecting details about the clothing worn and how and where the sensors were attached to the skin for achieving more precise results in the simulations.

  13. Revision and validation of a scale to assess pregnancy stress.

    PubMed

    Chen, Chung-Hey

    2015-03-01

    Pregnancy is a potentially stressful event. Prenatal stress alters maternal endocrine and immune systems, has been implicated in the etiology of prenatal complications or postnatal psychiatric disorders, and may adversely affect fetal health. The 30-item Pregnancy Stress Rating Scale (PSRS), initially developed in 1983 by Chen and colleagues, is the only measure to date designed specifically to evaluate prenatal stress. The purpose of this study was to reconsider and revise the 30-item PSRS and validate the new PSRS. A cross-sectional design was used. Adding new items of pregnancy stress generated from clinical experience and expert recommendations resulted in a 40-item revised PSRS that was more reflective of current social conditions. Three hundred pregnant women, recruited from the antenatal clinic of a medical center in southern Taiwan, completed the revised PSRS to assess its internal consistency, test-retest reliability, construct validity, and convergent and discriminate validity. The final 36-item PSRS (PSRS36) was derived by deleting four items with relatively low item-total correlation coefficients or factor loadings. The resultant 36-item scale showed good internal consistency (α = .92) and 2-week test-retest reliability (r = .82). Factor analysis confirmed construct validity and suggested five prenatal stress dimensions, which explained 52.17% of the total variance. Convergent and discriminate validities were indicated by significant correlations among the PSRS36, Perceived Stress Scale, and Interpersonal Support Evaluation List. The PSRS36 is a psychometrically sound and practical tool for nurses and other healthcare providers to assess prenatal stress and to examine intervention protocols in Taiwanese prenatal women. More research is recommended to determine whether the PSRS36 may be used in other racial-ethnic groups.

  14. Groundwater Model Validation

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Ahmed E. Hassan

    2006-01-24

    validation data to constrain model input parameters is shown for the second case study using a Bayesian approach known as Markov Chain Monte Carlo. The approach shows a great potential to be helpful in the validation process and in incorporating prior knowledge with new field data to derive posterior distributions for both model input and output.« less

  15. CFD Simulation and Experimental Validation of Fluid Flow and Particle Transport in a Model of Alveolated Airways

    PubMed Central

    Ma, Baoshun; Ruwet, Vincent; Corieri, Patricia; Theunissen, Raf; Riethmuller, Michel; Darquenne, Chantal

    2009-01-01

    Accurate modeling of air flow and aerosol transport in the alveolated airways is essential for quantitative predictions of pulmonary aerosol deposition. However, experimental validation of such modeling studies has been scarce. The objective of this study is to validate CFD predictions of flow field and particle trajectory with experiments within a scaled-up model of alveolated airways. Steady flow (Re = 0.13) of silicone oil was captured by particle image velocimetry (PIV), and the trajectories of 0.5 mm and 1.2 mm spherical iron beads (representing 0.7 to 14.6 μm aerosol in vivo) were obtained by particle tracking velocimetry (PTV). At twelve selected cross sections, the velocity profiles obtained by CFD matched well with those by PIV (within 1.7% on average). The CFD predicted trajectories also matched well with PTV experiments. These results showed that air flow and aerosol transport in models of human alveolated airways can be simulated by CFD techniques with reasonable accuracy. PMID:20161301

  16. CFD Simulation and Experimental Validation of Fluid Flow and Particle Transport in a Model of Alveolated Airways.

    PubMed

    Ma, Baoshun; Ruwet, Vincent; Corieri, Patricia; Theunissen, Raf; Riethmuller, Michel; Darquenne, Chantal

    2009-05-01

    Accurate modeling of air flow and aerosol transport in the alveolated airways is essential for quantitative predictions of pulmonary aerosol deposition. However, experimental validation of such modeling studies has been scarce. The objective of this study is to validate CFD predictions of flow field and particle trajectory with experiments within a scaled-up model of alveolated airways. Steady flow (Re = 0.13) of silicone oil was captured by particle image velocimetry (PIV), and the trajectories of 0.5 mm and 1.2 mm spherical iron beads (representing 0.7 to 14.6 mum aerosol in vivo) were obtained by particle tracking velocimetry (PTV). At twelve selected cross sections, the velocity profiles obtained by CFD matched well with those by PIV (within 1.7% on average). The CFD predicted trajectories also matched well with PTV experiments. These results showed that air flow and aerosol transport in models of human alveolated airways can be simulated by CFD techniques with reasonable accuracy.

  17. Sampling Participants’ Experience in Laboratory Experiments: Complementary Challenges for More Complete Data Collection

    PubMed Central

    McAuliffe, Alan; McGann, Marek

    2016-01-01

    Speelman and McGann’s (2013) examination of the uncritical way in which the mean is often used in psychological research raises questions both about the average’s reliability and its validity. In the present paper, we argue that interrogating the validity of the mean involves, amongst other things, a better understanding of the person’s experiences, the meaning of their actions, at the time that the behavior of interest is carried out. Recently emerging approaches within Psychology and Cognitive Science have argued strongly that experience should play a more central role in our examination of behavioral data, but the relationship between experience and behavior remains very poorly understood. We outline some of the history of the science on this fraught relationship, as well as arguing that contemporary methods for studying experience fall into one of two categories. “Wide” approaches tend to incorporate naturalistic behavior settings, but sacrifice accuracy and reliability in behavioral measurement. “Narrow” approaches maintain controlled measurement of behavior, but involve too specific a sampling of experience, which obscures crucial temporal characteristics. We therefore argue for a novel, mid-range sampling technique, that extends Hurlburt’s descriptive experience sampling, and adapts it for the controlled setting of the laboratory. This controlled descriptive experience sampling may be an appropriate tool to help calibrate both the mean and the meaning of an experimental situation with one another. PMID:27242588

  18. Benchmarking Multilayer-HySEA model for landslide generated tsunami. HTHMP validation process.

    NASA Astrophysics Data System (ADS)

    Macias, J.; Escalante, C.; Castro, M. J.

    2017-12-01

    Landslide tsunami hazard may be dominant along significant parts of the coastline around the world, in particular in the USA, as compared to hazards from other tsunamigenic sources. This fact motivated NTHMP about the need of benchmarking models for landslide generated tsunamis, following the same methodology already used for standard tsunami models when the source is seismic. To perform the above-mentioned validation process, a set of candidate benchmarks were proposed. These benchmarks are based on a subset of available laboratory data sets for solid slide experiments and deformable slide experiments, and include both submarine and subaerial slides. A benchmark based on a historic field event (Valdez, AK, 1964) close the list of proposed benchmarks. A total of 7 benchmarks. The Multilayer-HySEA model including non-hydrostatic effects has been used to perform all the benchmarking problems dealing with laboratory experiments proposed in the workshop that was organized at Texas A&M University - Galveston, on January 9-11, 2017 by NTHMP. The aim of this presentation is to show some of the latest numerical results obtained with the Multilayer-HySEA (non-hydrostatic) model in the framework of this validation effort.Acknowledgements. This research has been partially supported by the Spanish Government Research project SIMURISK (MTM2015-70490-C02-01-R) and University of Malaga, Campus de Excelencia Internacional Andalucía Tech. The GPU computations were performed at the Unit of Numerical Methods (University of Malaga).

  19. Valid methods: the quality assurance of test method development, validation, approval, and transfer for veterinary testing laboratories.

    PubMed

    Wiegers, Ann L

    2003-07-01

    Third-party accreditation is a valuable tool to demonstrate a laboratory's competence to conduct testing. Accreditation, internationally and in the United States, has been discussed previously. However, accreditation is only I part of establishing data credibility. A validated test method is the first component of a valid measurement system. Validation is defined as confirmation by examination and the provision of objective evidence that the particular requirements for a specific intended use are fulfilled. The international and national standard ISO/IEC 17025 recognizes the importance of validated methods and requires that laboratory-developed methods or methods adopted by the laboratory be appropriate for the intended use. Validated methods are therefore required and their use agreed to by the client (i.e., end users of the test results such as veterinarians, animal health programs, and owners). ISO/IEC 17025 also requires that the introduction of methods developed by the laboratory for its own use be a planned activity conducted by qualified personnel with adequate resources. This article discusses considerations and recommendations for the conduct of veterinary diagnostic test method development, validation, evaluation, approval, and transfer to the user laboratory in the ISO/IEC 17025 environment. These recommendations are based on those of nationally and internationally accepted standards and guidelines, as well as those of reputable and experienced technical bodies. They are also based on the author's experience in the evaluation of method development and transfer projects, validation data, and the implementation of quality management systems in the area of method development.

  20. Implicit attitudes towards homosexuality: reliability, validity, and controllability of the IAT.

    PubMed

    Banse, R; Seise, J; Zerbes, N

    2001-01-01

    Two experiments were conducted to investigate the psychometric properties of an Implicit Association Test (IAT; Greenwald, McGhee, & Schwartz, 1998) that was adapted to measure implicit attitudes towards homosexuality. In a first experiment, the validity of the Homosexuality-IAT was tested using a known group approach. Implicit and explicit attitudes were assessed in heterosexual and homosexual men and women (N = 101). The results provided compelling evidence for the convergent and discriminant validity of the Homosexuality-IAT as a measure of implicit attitudes. No evidence was found for two alternative explanations of IAT effects (familiarity with stimulus material and stereotype knowledge). The internal consistency of IAT scores was satisfactory (alpha s > .80), but retest correlations were lower. In a second experiment (N = 79) it was shown that uninformed participants were able to fake positive explicit but not implicit attitudes. Discrepancies between implicit and explicit attitudes towards homosexuality could be partially accounted for by individual differences in the motivation to control prejudiced behavior, thus providing independent evidence for the validity of the implicit attitude measure. Neither explicit nor implicit attitudes could be changed by persuasive messages. The results of both experiments are interpreted as evidence for a single construct account of implicit and explicit attitudes towards homosexuality.

  1. You don't have to believe everything you read: background knowledge permits fast and efficient validation of information.

    PubMed

    Richter, Tobias; Schroeder, Sascha; Wöhrmann, Britta

    2009-03-01

    In social cognition, knowledge-based validation of information is usually regarded as relying on strategic and resource-demanding processes. Research on language comprehension, in contrast, suggests that validation processes are involved in the construction of a referential representation of the communicated information. This view implies that individuals can use their knowledge to validate incoming information in a routine and efficient manner. Consistent with this idea, Experiments 1 and 2 demonstrated that individuals are able to reject false assertions efficiently when they have validity-relevant beliefs. Validation processes were carried out routinely even when individuals were put under additional cognitive load during comprehension. Experiment 3 demonstrated that the rejection of false information occurs automatically and interferes with affirmative responses in a nonsemantic task (epistemic Stroop effect). Experiment 4 also revealed complementary interference effects of true information with negative responses in a nonsemantic task. These results suggest the existence of fast and efficient validation processes that protect mental representations from being contaminated by false and inaccurate information.

  2. Development and validation of a critical gradient energetic particle driven Alfven eigenmode transport model for DIII-D tilted neutral beam experiments

    NASA Astrophysics Data System (ADS)

    Waltz, R. E.; Bass, E. M.; Heidbrink, W. W.; VanZeeland, M. A.

    2015-11-01

    Recent experiments with the DIII-D tilted neutral beam injection (NBI) varying the beam energetic particle (EP) source profiles have provided strong evidence that unstable Alfven eigenmodes (AE) drive stiff EP transport at a critical EP density gradient [Heidbrink et al 2013 Nucl. Fusion 53 093006]. Here the critical gradient is identified by the local AE growth rate being equal to the local ITG/TEM growth rate at the same low toroidal mode number. The growth rates are taken from the gyrokinetic code GYRO. Simulation show that the slowing down beam-like EP distribution has a slightly lower critical gradient than the Maxwellian. The ALPHA EP density transport code [Waltz and Bass 2014 Nucl. Fusion 54 104006], used to validate the model, combines the low-n stiff EP critical density gradient AE mid-core transport with the Angioni et al (2009 Nucl. Fusion 49 055013) energy independent high-n ITG/TEM density transport model controling the central core EP density profile. For the on-axis NBI heated DIII-D shot 146102, while the net loss to the edge is small, about half the birth fast ions are transported from the central core r/a  <  0.5 and the central density is about half the slowing down density. These results are in good agreement with experimental fast ion pressure profiles inferred from MSE constrained EFIT equilibria.

  3. Measuring the Pros and Cons of What It Means to Be a Black Man: Development and Validation of the Black Men's Experiences Scale (BMES).

    PubMed

    Bowleg, Lisa; English, Devin; Del Rio-Gonzalez, Ana Maria; Burkholder, Gary J; Teti, Michelle; Tschann, Jeanne M

    2016-04-01

    Although extensive research documents that Black people in the U.S. frequently experience social discrimination, most of this research aggregates these experiences primarily or exclusively by race. Consequently, empirical gaps exist about the psychosocial costs and benefits of Black men's experiences at the intersection of race and gender. Informed by intersectionality, a theoretical framework that highlights how multiple social identities intersect to reflect interlocking social-structural inequality, this study addresses these gaps with the qualitative development and quantitative test of the Black Men's Experiences Scale (BMES). The BMES assesses Black men's negative experiences with overt discrimination and microaggressions, as well their positive evaluations of what it means to be Black men. First, we conducted focus groups and individual interviews with Black men to develop the BMES. Next, we tested the BMES with 578 predominantly low-income urban Black men between the ages of 18 and 44. Exploratory factor analysis suggested a 12-item, 3-factor solution that explained 63.7% of the variance. We labeled the subscales: Overt Discrimination, Microaggressions, and Positives: Black Men . Confirmatory factor analysis supported the three-factor solution. As hypothesized, the BMES's subscales correlated with measures of racial discrimination, depression, resilience, and social class at the neighborhood-level. Preliminary evidence suggests that the BMES is a reliable and valid measure of Black men's experiences at the intersection of race and gender.

  4. Validation of Design and Analysis Techniques of Tailored Composite Structures

    NASA Technical Reports Server (NTRS)

    Jegley, Dawn C. (Technical Monitor); Wijayratne, Dulnath D.

    2004-01-01

    Aeroelasticity is the relationship between the elasticity of an aircraft structure and its aerodynamics. This relationship can cause instabilities such as flutter in a wing. Engineers have long studied aeroelasticity to ensure such instabilities do not become a problem within normal operating conditions. In recent decades structural tailoring has been used to take advantage of aeroelasticity. It is possible to tailor an aircraft structure to respond favorably to multiple different flight regimes such as takeoff, landing, cruise, 2-g pull up, etc. Structures can be designed so that these responses provide an aerodynamic advantage. This research investigates the ability to design and analyze tailored structures made from filamentary composites. Specifically the accuracy of tailored composite analysis must be verified if this design technique is to become feasible. To pursue this idea, a validation experiment has been performed on a small-scale filamentary composite wing box. The box is tailored such that its cover panels induce a global bend-twist coupling under an applied load. Two types of analysis were chosen for the experiment. The first is a closed form analysis based on a theoretical model of a single cell tailored box beam and the second is a finite element analysis. The predicted results are compared with the measured data to validate the analyses. The comparison of results show that the finite element analysis is capable of predicting displacements and strains to within 10% on the small-scale structure. The closed form code is consistently able to predict the wing box bending to 25% of the measured value. This error is expected due to simplifying assumptions in the closed form analysis. Differences between the closed form code representation and the wing box specimen caused large errors in the twist prediction. The closed form analysis prediction of twist has not been validated from this test.

  5. [Computerized system validation of clinical researches].

    PubMed

    Yan, Charles; Chen, Feng; Xia, Jia-lai; Zheng, Qing-shan; Liu, Daniel

    2015-11-01

    Validation is a documented process that provides a high degree of assurance. The computer system does exactly and consistently what it is designed to do in a controlled manner throughout the life. The validation process begins with the system proposal/requirements definition, and continues application and maintenance until system retirement and retention of the e-records based on regulatory rules. The objective to do so is to clearly specify that each application of information technology fulfills its purpose. The computer system validation (CSV) is essential in clinical studies according to the GCP standard, meeting product's pre-determined attributes of the specifications, quality, safety and traceability. This paper describes how to perform the validation process and determine relevant stakeholders within an organization in the light of validation SOPs. Although a specific accountability in the implementation of the validation process might be outsourced, the ultimate responsibility of the CSV remains on the shoulder of the business process owner-sponsor. In order to show that the compliance of the system validation has been properly attained, it is essential to set up comprehensive validation procedures and maintain adequate documentations as well as training records. Quality of the system validation should be controlled using both QC and QA means.

  6. Real Science: MIT Reality Show Tracks Experiences, Frustrations of Chemistry Lab Students

    ERIC Educational Resources Information Center

    Cooper, Kenneth J.

    2012-01-01

    A reality show about a college course--a chemistry class no less? That's what "ChemLab Boot Camp" is. The 14-part series of short videos is being released one episode at a time on the online learning site of the Massachusetts Institute of Technology. The novel show follows a diverse group of 14 freshmen as they struggle to master the…

  7. The SATISPSY-22: development and validation of a French hospitalized patients' satisfaction questionnaire in psychiatry.

    PubMed

    Zendjidjian, X Y; Auquier, P; Lançon, C; Loundou, A; Parola, N; Faugère, M; Boyer, L

    2015-01-01

    The aim of our study was to develop a specific French self-administered instrument for measuring hospitalized patients' satisfaction in psychiatry based on exclusive patient point of view: the SATISPSY-22. The development of the SATISPSY was undertaken in three steps: item generation, item reduction, and validation. The content of the SATISPSY was derived from 80 interviews with patients hospitalized in psychiatry. Using item response and classical test theories, item reduction was performed in 2 hospitals on 270 responders. The validation was based on construct validity, reliability, and some aspects of external validity. The SATISPSY contains 22 items describing 6 dimensions (staff, quality of care, personal experience, information, activity, and food). The six-factor structure accounted for 78.0% of the total variance. Each item achieved the 0.40 standard for item-internal consistency, and the Cronbach's alpha coefficients were>0.70. Scores of dimensions were strongly positively correlated with Visual Analogue Scale scores. Significant associations with socioeconomic and clinical indicators showed good discriminant and external validity. INFIT statistics were ranged from 0.71 to 1.25. The SATISPSY-22 presents satisfactory psychometric properties, enabling patient feedback to be incorporated in a continuous quality health care improvement strategy. Copyright © 2014 Elsevier Masson SAS. All rights reserved.

  8. Psychological and Biological Validation of a Novel Digital Social Peer Evaluation Experiment (digi-SPEE).

    PubMed

    Menne-Lothmann, Claudia; Decoster, Jeroen; van Winkel, Ruud; Collip, Dina; Rutten, Bart P F; Delespaul, Philippe; De Hert, Marc; Derom, Catherine; Thiery, Evert; Jacobs, Nele; van Os, Jim; Wichers, Marieke

    2017-03-01

    Negative social evaluation is associated with psychopathology. Given the frequency of evaluation through increasingly prevalent virtual social networks, increased understanding of the effects of this social evaluation is urgently required. A new digital social peer evaluation experiment (digi-SPEE) was developed to mimic everyday online social interactions between peers. Participants received mildly negative feedback on their appearance, intelligence, and congeniality. Two hundred and forty-one young people [58.9% female, aged 18.9 years (15 to 34)] from an ongoing novel general population twin study participated in this study. Positive affect (PA), negative affect (NA), implicit self-esteem, and cortisol were assessed before and after exposure to the social evaluation experiment. The social evaluation experiment decreased PA (B=-5.25, p<.001) and implicit self-esteem (B=-.19; p<.001), whereas it increased NA (B=5.99; p<.001) and cortisol levels (B=.07; p<.001). Females (PA: B=-7.62; p<.001; NA: B=8.28; p<.001) and participants with higher levels of general psychological distress (PA: B=-.04, p=.035; NA: B=.06; p=.028) showed stronger affective responses. Stressor-induced cortisol increase was stronger in adolescents under the age of 18 than in participants 18 years and older (B=-.06, p=.002). The digi-SPEE represents a social evaluation stressor that elicits biological and implicit and explicit mental changes that are relevant to mechanisms of psychopathology.

  9. Ensuring the validity of calculated subcritical limits

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Clark, H.K.

    1977-01-01

    The care taken at the Savannah River Laboratory and Plant to ensure the validity of calculated subcritical limits is described. Close attention is given to ANSI N16.1-1975, ''Validation of Calculational Methods for Nuclear Criticality Safety.'' The computer codes used for criticality safety computations, which are listed and are briefly described, have been placed in the SRL JOSHUA system to facilitate calculation and to reduce input errors. A driver module, KOKO, simplifies and standardizes input and links the codes together in various ways. For any criticality safety evaluation, correlations of the calculational methods are made with experiment to establish bias. Occasionallymore » subcritical experiments are performed expressly to provide benchmarks. Calculated subcritical limits contain an adequate but not excessive margin to allow for uncertainty in the bias. The final step in any criticality safety evaluation is the writing of a report describing the calculations and justifying the margin.« less

  10. Where the Boys Are: Show Chorus.

    ERIC Educational Resources Information Center

    Mancuso, Sandra L.

    1983-01-01

    Boys are given a chance to experience choral music through the aid of a system that lessens peer pressure. Through auditions, the teacher can evaluate musical ability, coordination level, interaction with peers, and ability to learn rapidly. Show chorus has brought a unique interest to the music program. (AU/CS)

  11. The Nottingham Adjustment Scale: a validation study.

    PubMed

    Dodds, A G; Flannigan, H; Ng, L

    1993-09-01

    The concept of adjustment to acquired sight loss is examined in the context of existing loss models. An alternative conceptual framework is presented which addresses the 'blindness experience', and which suggests that the depression so frequently encountered in those losing their sight can be understood better by recourse to cognitive factors than to psychoanalytically based theories of grieving. A scale to measure psychological status before and after rehabilitation is described, its factorial validity is demonstrated, and its validity in enabling changes to be measured. Practitioners are encouraged to adopt a similar perspective in other areas of acquired disability.

  12. Experimental validation of predicted cancer genes using FRET

    NASA Astrophysics Data System (ADS)

    Guala, Dimitri; Bernhem, Kristoffer; Ait Blal, Hammou; Jans, Daniel; Lundberg, Emma; Brismar, Hjalmar; Sonnhammer, Erik L. L.

    2018-07-01

    Huge amounts of data are generated in genome wide experiments, designed to investigate diseases with complex genetic causes. Follow up of all potential leads produced by such experiments is currently cost prohibitive and time consuming. Gene prioritization tools alleviate these constraints by directing further experimental efforts towards the most promising candidate targets. Recently a gene prioritization tool called MaxLink was shown to outperform other widely used state-of-the-art prioritization tools in a large scale in silico benchmark. An experimental validation of predictions made by MaxLink has however been lacking. In this study we used Fluorescence Resonance Energy Transfer, an established experimental technique for detection of protein-protein interactions, to validate potential cancer genes predicted by MaxLink. Our results provide confidence in the use of MaxLink for selection of new targets in the battle with polygenic diseases.

  13. MRPrimerW: a tool for rapid design of valid high-quality primers for multiple target qPCR experiments

    PubMed Central

    Kim, Hyerin; Kang, NaNa; An, KyuHyeon; Koo, JaeHyung; Kim, Min-Soo

    2016-01-01

    Design of high-quality primers for multiple target sequences is essential for qPCR experiments, but is challenging due to the need to consider both homology tests on off-target sequences and the same stringent filtering constraints on the primers. Existing web servers for primer design have major drawbacks, including requiring the use of BLAST-like tools for homology tests, lack of support for ranking of primers, TaqMan probes and simultaneous design of primers against multiple targets. Due to the large-scale computational overhead, the few web servers supporting homology tests use heuristic approaches or perform homology tests within a limited scope. Here, we describe the MRPrimerW, which performs complete homology testing, supports batch design of primers for multi-target qPCR experiments, supports design of TaqMan probes and ranks the resulting primers to return the top-1 best primers to the user. To ensure high accuracy, we adopted the core algorithm of a previously reported MapReduce-based method, MRPrimer, but completely redesigned it to allow users to receive query results quickly in a web interface, without requiring a MapReduce cluster or a long computation. MRPrimerW provides primer design services and a complete set of 341 963 135 in silico validated primers covering 99% of human and mouse genes. Free access: http://MRPrimerW.com. PMID:27154272

  14. Validation of gamma irradiator controls for quality and regulatory compliance

    NASA Astrophysics Data System (ADS)

    Harding, Rorry B.; Pinteric, Francis J. A.

    1995-09-01

    Since 1978 the U.S. Food and Drug Administration (FDA) has had both the legal authority and the Current Good Manufacturing Practice (CGMP) regulations in place to require irradiator owners who process medical devices to produce evidence of Irradiation Process Validation. One of the key components of Irradiation Process Validation is the validation of the irradiator controls. However, it is only recently that FDA audits have focused on this component of the process validation. What is Irradiator Control System Validation? What constitutes evidence of control? How do owners obtain evidence? What is the irradiator supplier's role in validation? How does the ISO 9000 Quality Standard relate to the FDA's CGMP requirement for evidence of Control System Validation? This paper presents answers to these questions based on the recent experiences of Nordion's engineering and product management staff who have worked with several US-based irradiator owners. This topic — Validation of Irradiator Controls — is a significant regulatory compliance and operations issue within the irradiator suppliers' and users' community.

  15. Validation of CESAR Thermal-hydraulic Module of ASTEC V1.2 Code on BETHSY Experiments

    NASA Astrophysics Data System (ADS)

    Tregoures, Nicolas; Bandini, Giacomino; Foucher, Laurent; Fleurot, Joëlle; Meloni, Paride

    The ASTEC V1 system code is being jointly developed by the French Institut de Radioprotection et Sûreté Nucléaire (IRSN) and the German Gesellschaft für Anlagen und ReaktorSicherheit (GRS) to address severe accident sequences in a nuclear power plant. Thermal-hydraulics in primary and secondary system is addressed by the CESAR module. The aim of this paper is to present the validation of the CESAR module, from the ASTEC V1.2 version, on the basis of well instrumented and qualified integral experiments carried out in the BETHSY facility (CEA, France), which simulates a French 900 MWe PWR reactor. Three tests have been thoroughly investigated with CESAR: the loss of coolant 9.1b test (OECD ISP N° 27), the loss of feedwater 5.2e test, and the multiple steam generator tube rupture 4.3b test. In the present paper, the results of the code for the three analyzed tests are presented in comparison with the experimental data. The thermal-hydraulic behavior of the BETHSY facility during the transient phase is well reproduced by CESAR: the occurrence of major events and the time evolution of main thermal-hydraulic parameters of both primary and secondary circuits are well predicted.

  16. Examining Factor Structure and Validating the Persian Version of the Pregnancy's Worries and Stress Questionnaire for Pregnant Iranian Women.

    PubMed

    Navidpour, Fariba; Dolatian, Mahrokh; Yaghmaei, Farideh; Majd, Hamid Alavi; Hashemi, Seyed Saeed

    2015-04-23

    Pregnant women tend to experience anxiety and stress when faced with the changes to their biology, environment and personal relationships. The identification of these factors and the prevention of their side effects are vital for both mother and fetus. The present study was conducted to validate and to examine the factor structure of the Persian version of the Pregnancy's Worries and Stress Questionnaire. The 25-item PWSQ was first translated by specialists into Persian. The questionnaire's validity was determined using face, content, criterion and construct validity and reliability of questionnaire was examined using Cronbach's alpha. Confirmatory factor analysis was performed in AMOS and SPSS 21. Participants included healthy Iranian pregnant women (8-39 weeks) who refer to selected hospitals for prenatal care. Hospitals included private, social security and university hospitals and selected through the random cluster sampling method. The results of validity and reliability assessments of the questionnaire were acceptable. Cronbach's alpha calculated showed a high internal consistency of 0.89. The confirmatory factor analysis using the c2, CMIN/DF, IFI, CFI, NFI and NNFI indexes showed the 6-factor model to be the best fitted model for explaining the data. The questionnaire was translated into Persian to examine stress and worry specific to Iranian pregnant women. The psychometric results showed that the questionnaire is suitable for identifying Iranian pregnant women with pregnancy-related stress.

  17. Experiment for validation of fluid-structure interaction models and algorithms.

    PubMed

    Hessenthaler, A; Gaddum, N R; Holub, O; Sinkus, R; Röhrle, O; Nordsletten, D

    2017-09-01

    In this paper a fluid-structure interaction (FSI) experiment is presented. The aim of this experiment is to provide a challenging yet easy-to-setup FSI test case that addresses the need for rigorous testing of FSI algorithms and modeling frameworks. Steady-state and periodic steady-state test cases with constant and periodic inflow were established. Focus of the experiment is on biomedical engineering applications with flow being in the laminar regime with Reynolds numbers 1283 and 651. Flow and solid domains were defined using computer-aided design (CAD) tools. The experimental design aimed at providing a straightforward boundary condition definition. Material parameters and mechanical response of a moderately viscous Newtonian fluid and a nonlinear incompressible solid were experimentally determined. A comprehensive data set was acquired by using magnetic resonance imaging to record the interaction between the fluid and the solid, quantifying flow and solid motion. Copyright © 2016 The Authors. International Journal for Numerical Methods in Biomedical Engineering published by John Wiley & Sons Ltd.

  18. Adaptation and validation of the patient assessment of chronic illness care in the French context.

    PubMed

    Krucien, Nicolas; Le Vaillant, Marc; Pelletier-Fleury, Nathalie

    2014-06-19

    Chronic diseases are major causes of disability worldwide with rising prevalence. Most patients suffering from chronic conditions do not always receive optimal care. The Chronic Care Model (CCM) has been developed to help general practitioners making quality improvements. The Patient Assessment of Chronic Illness Care (PACIC) questionnaire was increasingly used in several countries to appraise the implementation of the CCM from the patients' perspective. The objective of this study was to adapt the PACIC questionnaire in the French context and to test the validity of this adaptation in a sample of patients with multiple chronic conditions. The PACIC was translated into French language using a forward/backward procedure. The French version was validated using a sample of 150 patients treated for obstructive sleep apnea syndrome (OSAS) and having multiple chronic co-morbidities. Several forms of validity were analysed: content; face; construct; and internal consistency. The construct validity was investigated with an exploratory factorial analysis. The French-version of the PACIC consisted in 18 items, after merging two pairs of items due to redundancy. The high number of items exhibiting floor/ceiling effects and the non-normality of the ratings suggested that a 5-points rating scale was somewhat inappropriate to assess the patients' experience of care. The construct validity of the French-PACIC was verified and resulted in a bi-dimensional structure. Overall this structure showed a high level of internal consistency. The PACIC score appeared to be significantly related to the age and self-reported health of the patients. A French-version of the PACIC questionnaire is now available to evaluate the patients' experience of care and to monitor the quality improvements realised by the medical structures. This study also pointed out some methodological issues about the PACIC questionnaire, related to the format of the rating scale and to the structure of the

  19. Increased importance of the documented development stage in process validation.

    PubMed

    Mohammed-Ziegler, Ildikó; Medgyesi, Ildikó

    2012-07-01

    Current trends in pharmaceutical quality assurance moved when the Federal Drug Administration (FDA) of the USA published its new guideline on process validation in 2011. This guidance introduced the lifecycle approach of process validation. In this short communication some typical changes from the point of view of practice of API production are addressed in the light of inspection experiences. Some details are compared with the European regulations.

  20. Automated validation of patient safety clinical incident classification: macro analysis.

    PubMed

    Gupta, Jaiprakash; Patrick, Jon

    2013-01-01

    Patient safety is the buzz word in healthcare. Incident Information Management System (IIMS) is electronic software that stores clinical mishaps narratives in places where patients are treated. It is estimated that in one state alone over one million electronic text documents are available in IIMS. In this paper we investigate the data density available in the fields entered to notify an incident and the validity of the built in classification used by clinician to categories the incidents. Waikato Environment for Knowledge Analysis (WEKA) software was used to test the classes. Four statistical classifier based on J48, Naïve Bayes (NB), Naïve Bayes Multinominal (NBM) and Support Vector Machine using radial basis function (SVM_RBF) algorithms were used to validate the classes. The data pool was 10,000 clinical incidents drawn from 7 hospitals in one state in Australia. In first part of the study 1000 clinical incidents were selected to determine type and number of fields worth investigating and in the second part another 5448 clinical incidents were randomly selected to validate 13 clinical incident types. Result shows 74.6% of the cells were empty and only 23 fields had content over 70% of the time. The percentage correctly classified classes on four algorithms using categorical dataset ranged from 42 to 49%, using free-text datasets from 65% to 77% and using both datasets from 72% to 79%. Kappa statistic ranged from 0.36 to 0.4. for categorical data, from 0.61 to 0.74. for free-text and from 0.67 to 0.77 for both datasets. Similar increases in performance in the 3 experiments was noted on true positive rate, precision, F-measure and area under curve (AUC) of receiver operating characteristics (ROC) scores. The study demonstrates only 14 of 73 fields in IIMS have data that is usable for machine learning experiments. Irrespective of the type of algorithms used when all datasets are used performance was better. Classifier NBM showed best performance. We think the

  1. Demonstrating Experimenter "Ineptitude" as a Means of Teaching Internal and External Validity

    ERIC Educational Resources Information Center

    Treadwell, Kimberli R.H.

    2008-01-01

    Internal and external validity are key concepts in understanding the scientific method and fostering critical thinking. This article describes a class demonstration of a "botched" experiment to teach validity to undergraduates. Psychology students (N = 75) completed assessments at the beginning of the semester, prior to and immediately following…

  2. Reliability and validity: Part II.

    PubMed

    Davis, Debora Winders

    2004-01-01

    Determining measurement reliability and validity involves complex processes. There is usually room for argument about most instruments. It is important that the researcher clearly describes the processes upon which she made the decision to use a particular instrument, and presents the evidence available showing that the instrument is reliable and valid for the current purposes. In some cases, the researcher may need to conduct pilot studies to obtain evidence upon which to decide whether the instrument is valid for a new population or a different setting. In all cases, the researcher must present a clear and complete explanation for the choices, she has made regarding reliability and validity. The consumer must then judge the degree to which the researcher has provided adequate and theoretically sound rationale. Although I have tried to touch on most of the important concepts related to measurement reliability and validity, it is beyond the scope of this column to be exhaustive. There are textbooks devoted entirely to specific measurement issues if readers require more in-depth knowledge.

  3. Numerical Simulation of Tuff Dissolution and Precipitation Experiments: Validation of Thermal-Hydrologic-Chemical (THC) Coupled-Process Modeling

    NASA Astrophysics Data System (ADS)

    Dobson, P. F.; Kneafsey, T. J.

    2001-12-01

    As part of an ongoing effort to evaluate THC effects on flow in fractured media, we performed a laboratory experiment and numerical simulations to investigate mineral dissolution and precipitation. To replicate mineral dissolution by condensate in fractured tuff, deionized water equilibrated with carbon dioxide was flowed for 1,500 hours through crushed Yucca Mountain tuff at 94° C. The reacted water was collected and sampled for major dissolved species, total alkalinity, electrical conductivity, and pH. The resulting steady-state fluid composition had a total dissolved solids content of about 140 mg/L; silica was the dominant dissolved constituent. A portion of the steady-state reacted water was flowed at 10.8 mL/hr into a 31.7-cm tall, 16.2-cm wide vertically oriented planar fracture with a hydraulic aperture of 31 microns in a block of welded Topopah Spring tuff that was maintained at 80° C at the top and 130° C at the bottom. The fracture began to seal within five days. A 1-D plug-flow model using the TOUGHREACT code developed at Berkeley Lab was used to simulate mineral dissolution, and a 2-D model was developed to simulate the flow of mineralized water through a planar fracture, where boiling conditions led to mineral precipitation. Predicted concentrations of the major dissolved constituents for the tuff dissolution were within a factor of 2 of the measured average steady-state compositions. The fracture-plugging simulations result in the precipitation of amorphous silica at the base of the boiling front, leading to a hundred-fold decrease in fracture permeability in less than 6 days, consistent with the laboratory experiment. These results help validate the use of the TOUGHREACT code for THC modeling of the Yucca Mountain system. The experiment and simulations indicate that boiling and concomitant precipitation of amorphous silica could cause significant reductions in fracture porosity and permeability on a local scale. The TOUGHREACT code will be used

  4. Hadron production experiments

    NASA Astrophysics Data System (ADS)

    Popov, Boris A.

    2013-02-01

    The HARP and NA61/SHINE hadroproduction experiments as well as their implications for neutrino physics are discussed. HARP measurements have already been used for predictions of neutrino beams in K2K and MiniBooNE/SciBooNE experiments and are also being used to improve the atmospheric neutrino flux predictions and to help in the optimization of neutrino factory and super-beam designs. First measurements released recently by the NA61/SHINE experiment are of significant importance for a precise prediction of the J-PARC neutrino beam used for the T2K experiment. Both HARP and NA61/SHINE experiments provide also a large amount of input for validation and tuning of hadron production models in Monte-Carlo generators.

  5. Threats to validity in the design and conduct of preclinical efficacy studies: a systematic review of guidelines for in vivo animal experiments.

    PubMed

    Henderson, Valerie C; Kimmelman, Jonathan; Fergusson, Dean; Grimshaw, Jeremy M; Hackam, Dan G

    2013-01-01

    The vast majority of medical interventions introduced into clinical development prove unsafe or ineffective. One prominent explanation for the dismal success rate is flawed preclinical research. We conducted a systematic review of preclinical research guidelines and organized recommendations according to the type of validity threat (internal, construct, or external) or programmatic research activity they primarily address. We searched MEDLINE, Google Scholar, Google, and the EQUATOR Network website for all preclinical guideline documents published up to April 9, 2013 that addressed the design and conduct of in vivo animal experiments aimed at supporting clinical translation. To be eligible, documents had to provide guidance on the design or execution of preclinical animal experiments and represent the aggregated consensus of four or more investigators. Data from included guidelines were independently extracted by two individuals for discrete recommendations on the design and implementation of preclinical efficacy studies. These recommendations were then organized according to the type of validity threat they addressed. A total of 2,029 citations were identified through our search strategy. From these, we identified 26 guidelines that met our eligibility criteria--most of which were directed at neurological or cerebrovascular drug development. Together, these guidelines offered 55 different recommendations. Some of the most common recommendations included performance of a power calculation to determine sample size, randomized treatment allocation, and characterization of disease phenotype in the animal model prior to experimentation. By identifying the most recurrent recommendations among preclinical guidelines, we provide a starting point for developing preclinical guidelines in other disease domains. We also provide a basis for the study and evaluation of preclinical research practice. Please see later in the article for the Editors' Summary.

  6. An Imposed Dynamo Current Drive Experiment: Demonstration of Confinement

    NASA Astrophysics Data System (ADS)

    Jarboe, Thomas; Hansen, Chris; Hossack, Aaron; Marklin, George; Morgan, Kyle; Nelson, Brian; Sutherland, Derek; Victor, Brian

    2014-10-01

    An experiment for studying and developing the efficient sustainment of a spheromak with sufficient confinement (current-drive power heats the plasma to its stability β-limit) and in the keV temperature range is discussed. A high- β spheromak sustained by imposed dynamo current drive (IDCD) is justified because: previous transient experiments showed sufficient confinement in the keV range with no external toroidal field coil; recent results on HIT-SI show sustainment with sufficient confinement at low temperature; the potential of IDCD of solving other fusion issues; a very attractive reactor concept; and the general need for efficient current drive in magnetic fusion. The design of a 0.55 m minor radius machine with the required density control, wall loading, and neutral shielding for a 2 s pulse is presented. Peak temperatures of 1 keV and toroidal currents of 1.35 MA and 16% wall-normalized plasma beta are envisioned. The experiment is large enough to address the key issues yet small enough for rapid modification and for extended MHD modeling of startup and code validation.

  7. Validity of Highlighting on Text Comprehension

    NASA Astrophysics Data System (ADS)

    So, Joey C. Y.; Chan, Alan H. S.

    2009-10-01

    In this study, 38 university students were tested with a Chinese reading task on an LED display under different task conditions for determining the effects of the highlighting and its validity on comprehension performance on light-emitting diodes (LED) display for Chinese reading. Four levels of validity (0%, 33%, 67% and 100%) and a control condition with no highlighting were tested. Each subject was required to perform the five experimental conditions in which different passages were read and comprehended. The results showed that the condition with 100% validity of highlighting was found to have better comprehension performance than other validity levels and conditions with no highlighting. The comprehension score of the condition without highlighting effect was comparatively lower than those highlighting conditions with distracters, though not significant.

  8. Construction and Validation of an Instrument to Measure Taiwanese Elementary Students' Attitudes toward Their Science Class

    NASA Astrophysics Data System (ADS)

    Wang, Tzu-Ling; Berlin, Donna

    2010-12-01

    The main purpose of this study is to develop a valid and reliable instrument for measuring the attitudes toward science class of fourth- and fifth-grade students in an Asian school culture. Specifically, the development focused on three science attitude constructs-science enjoyment, science confidence, and importance of science as related to science class experiences. A total of 265 elementary school students in Taiwan responded to the instrument developed. Data analysis indicated that the instrument exhibited satisfactory validity and reliability with the Taiwan population used. The Cronbach's alpha coefficient was 0.93 for the entire instrument indicating a satisfactory level of internal consistency. However, both principal component analysis and parallel analysis showed that the three attitude scales were not unique and should be combined and used as a general "attitudes toward science class" scale. The analysis also showed that there were no gender or grade-level differences in students' overall attitudes toward science class.

  9. Pain patients' experiences of validation and invalidation from physicians before and after multimodal pain rehabilitation: Associations with pain, negative affectivity, and treatment outcome.

    PubMed

    Edlund, Sara M; Wurm, Matilda; Holländare, Fredrik; Linton, Steven J; Fruzzetti, Alan E; Tillfors, Maria

    2017-10-01

    were only found post-treatment. This appeared to be due to the pre- and post-heightened invalidation clusters not containing the same individuals. Therefore, additional analyses were conducted to investigate the individuals who changed clusters. Results showed that patients scoring high on negative affectivity ended up in the heightened invalidation cluster post-treatment. Taken together, most patients felt understood when communicating with their rehabilitation physician. However, a smaller group of patients experienced the opposite: low levels of validation and heightened levels of invalidation. This group stood out as more problematic, reporting greater pain interference and negative affectivity when compared to the other groups after treatment. Patient perceptions were typically stable over time, but some individuals changed cluster, and these movements seemed to be related to negative affectivity and pain interference. These results do not support a connection between perceived validation and invalidation from physicians (meeting the patients pre- and post-treatment) and treatment outcome. Overall, our results suggest that there is a connection between negative affectivity and pain interference in the patients, and perceived validation and invalidation from the physicians. In clinical practice, it is important to pay attention to comorbid psychological problems and level of pain interference, since these factors may negatively influence effective communication. A focus on decreasing invalidating responses and/or increasing validating responses might be particularly important for patients with high levels of psychological problems and pain interference. Copyright © 2017. Published by Elsevier B.V.

  10. Construct and concurrent validity of a Nintendo Wii video game made for training basic laparoscopic skills.

    PubMed

    Jalink, M B; Goris, J; Heineman, E; Pierie, J P E N; ten Cate Hoedemaker, H O

    2014-02-01

    Virtual reality (VR) laparoscopic simulators have been around for more than 10 years and have proven to be cost- and time-effective in laparoscopic skills training. However, most simulators are, in our experience, considered less interesting by residents and are often poorly accessible. Consequently, these devices are rarely used in actual training. In an effort to make a low-cost and more attractive simulator, a custom-made Nintendo Wii game was developed. This game could ultimately be used to train the same basic skills as VR laparoscopic simulators ought to. Before such a video game can be implemented into a surgical training program, it has to be validated according to international standards. The main goal of this study was to test construct and concurrent validity of the controls of a prototype of the game. In this study, the basic laparoscopic skills of experts (surgeons, urologists, and gynecologists, n = 15) were compared to those of complete novices (internists, n = 15) using the Wii Laparoscopy (construct validity). Scores were also compared to the Fundamentals of Laparoscopy (FLS) Peg Transfer test, an already established assessment method for measuring basic laparoscopic skills (concurrent validity). Results showed that experts were 111 % faster (P = 0.001) on the Wii Laparoscopy task than novices. Also, scores of the FLS Peg Transfer test and the Wii Laparoscopy showed a significant, high correlation (r = 0.812, P < 0.001). The prototype setup of the Wii Laparoscopy possesses solid construct and concurrent validity.

  11. International Energy Agency Ocean Energy Systems Task 10 Wave Energy Converter Modeling Verification and Validation: Preprint

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Wendt, Fabian F; Yu, Yi-Hsiang; Nielsen, Kim

    This is the first joint reference paper for the Ocean Energy Systems (OES) Task 10 Wave Energy Converter modeling verification and validation group. The group is established under the OES Energy Technology Network program under the International Energy Agency. OES was founded in 2001 and Task 10 was proposed by Bob Thresher (National Renewable Energy Laboratory) in 2015 and approved by the OES Executive Committee EXCO in 2016. The kickoff workshop took place in September 2016, wherein the initial baseline task was defined. Experience from similar offshore wind validation/verification projects (OC3-OC5 conducted within the International Energy Agency Wind Task 30)more » [1], [2] showed that a simple test case would help the initial cooperation to present results in a comparable way. A heaving sphere was chosen as the first test case. The team of project participants simulated different numerical experiments, such as heave decay tests and regular and irregular wave cases. The simulation results are presented and discussed in this paper.« less

  12. Standing wave design and experimental validation of a tandem simulated moving bed process for insulin purification.

    PubMed

    Xie, Yi; Mun, Sungyong; Kim, Jinhyun; Wang, Nien-Hwa Linda

    2002-01-01

    A tandem simulated moving bed (SMB) process for insulin purification has been proposed and validated experimentally. The mixture to be separated consists of insulin, high molecular weight proteins, and zinc chloride. A systematic approach based on the standing wave design, rate model simulations, and experiments was used to develop this multicomponent separation process. The standing wave design was applied to specify the SMB operating conditions of a lab-scale unit with 10 columns. The design was validated with rate model simulations prior to experiments. The experimental results show 99.9% purity and 99% yield, which closely agree with the model predictions and the standing wave design targets. The agreement proves that the standing wave design can ensure high purity and high yield for the tandem SMB process. Compared to a conventional batch SEC process, the tandem SMB has 10% higher yield, 400% higher throughput, and 72% lower eluant consumption. In contrast, a design that ignores the effects of mass transfer and nonideal flow cannot meet the purity requirement and gives less than 96% yield.

  13. [Ethic review on clinical experiments of medical devices in medical institutions].

    PubMed

    Shuai, Wanjun; Chao, Yong; Wang, Ning; Xu, Shining

    2011-07-01

    Clinical experiments are always used to evaluate the safety and validity of medical devices. The experiments have two types of clinical trying and testing. Ethic review must be done by the ethics committee of the medical department with the qualification of clinical research, and the approval must be made before the experiments. In order to ensure the safety and validity of clinical experiments of medical devices in medical institutions, the contents, process and approval criterions of the ethic review were analyzed and discussed.

  14. The role of failure modes and effects analysis in showing the benefits of automation in the blood bank.

    PubMed

    Han, Tae Hee; Kim, Moon Jung; Kim, Shinyoung; Kim, Hyun Ok; Lee, Mi Ae; Choi, Ji Seon; Hur, Mina; St John, Andrew

    2013-05-01

    Failure modes and effects analysis (FMEA) is a risk management tool used by the manufacturing industry but now being applied in laboratories. Teams from six South Korean blood banks used this tool to map their manual and automated blood grouping processes and determine the risk priority numbers (RPNs) as a total measure of error risk. The RPNs determined by each of the teams consistently showed that the use of automation dramatically reduced the RPN compared to manual processes. In addition, FMEA showed where the major risks occur in each of the manual processes and where attention should be prioritized to improve the process. Despite no previous experience with FMEA, the teams found the technique relatively easy to use and the subjectivity associated with assigning risk numbers did not affect the validity of the data. FMEA should become a routine technique for improving processes in laboratories. © 2012 American Association of Blood Banks.

  15. Validation of Magnetic Resonance Thermometry by Computational Fluid Dynamics

    NASA Astrophysics Data System (ADS)

    Rydquist, Grant; Owkes, Mark; Verhulst, Claire M.; Benson, Michael J.; Vanpoppel, Bret P.; Burton, Sascha; Eaton, John K.; Elkins, Christopher P.

    2016-11-01

    Magnetic Resonance Thermometry (MRT) is a new experimental technique that can create fully three-dimensional temperature fields in a noninvasive manner. However, validation is still required to determine the accuracy of measured results. One method of examination is to compare data gathered experimentally to data computed with computational fluid dynamics (CFD). In this study, large-eddy simulations have been performed with the NGA computational platform to generate data for a comparison with previously run MRT experiments. The experimental setup consisted of a heated jet inclined at 30° injected into a larger channel. In the simulations, viscosity and density were scaled according to the local temperature to account for differences in buoyant and viscous forces. A mesh-independent study was performed with 5 mil-, 15 mil- and 45 mil-cell meshes. The program Star-CCM + was used to simulate the complete experimental geometry. This was compared to data generated from NGA. Overall, both programs show good agreement with the experimental data gathered with MRT. With this data, the validity of MRT as a diagnostic tool has been shown and the tool can be used to further our understanding of a range of flows with non-trivial temperature distributions.

  16. Development and validation of a Chinese music quality rating test.

    PubMed

    Cai, Yuexin; Zhao, Fei; Zheng, Yiqing

    2013-09-01

    The present study aims to develop and validate a Chinese music quality rating test (MQRT). In Experiment 1, 22 music pieces were initially selected and paired as a 'familiar music piece' and 'unfamiliar music piece' based on familiarities amongst the general public in the categories of classical music (6), Chinese folk music (8), and pop music (8). Following the selection criteria, one pair of music pieces from each music category was selected and used for the MQRT in Experiment 2. In Experiment 2, the MQRT was validated using these music pieces in the categories 'Pleasantness', 'Naturalness', 'Fullness', 'Roughness', and 'Sharpness'. Seventy-two adult participants and 30 normal-hearing listeners were recruited in Experiments 1 and 2, respectively. Significant differences between the familiar and unfamiliar music pieces were found in respect of pleasantness rating for folk and pop music pieces as well as in sharpness rating for pop music pieces. The comparison of music category effect on MQRT found significant differences in pleasantness, fullness, and sharpness ratings. The Chinese MQRT developed in the present study is an effective tool for assessing music quality.

  17. Remote Agent Experiment

    NASA Technical Reports Server (NTRS)

    Benard, Doug; Dorais, Gregory A.; Gamble, Ed; Kanefsky, Bob; Kurien, James; Millar, William; Muscettola, Nicola; Nayak, Pandu; Rouquette, Nicolas; Rajan, Kanna; hide

    2000-01-01

    Remote Agent (RA) is a model-based, reusable artificial intelligence (At) software system that enables goal-based spacecraft commanding and robust fault recovery. RA was flight validated during an experiment on board of DS1 between May 17th and May 21th, 1999.

  18. A new questionnaire to assess endorsement of normative ethics in primary health care: development, reliability and validity study.

    PubMed

    González-de Paz, Luis; Devant-Altimir, Meritxell; Kostov, Belchin; Mitjavila-López, Joan; Navarro-Rubio, M Dolors; Sisó-Almirall, Antoni

    2013-12-01

    Assessing ethical endorsement is crucial to the study of professional performance and moral conduct. There are no specific instruments that verify patients and professional experiences of ethical practice in the specific area of primary health care (PHC). To study the psychometric properties of two questionnaires to identify professional and patient endorsement of normative ethics. A methodological study conducted in PHC centres from an urban area (Barcelona). A group of items from an ethical code were generated using a qualitative study with focus groups. Items underwent expert validation, item refinement and test-retest reliability. Two groups of items for PHC professionals and patients were validated. The structure of the constructs and the internal consistency were studied after participants completed the questionnaires. Principal component analysis with supplementary variables showed the utility of the validated questionnaires. The patients' questionnaire consisted of 17 general items plus 11 additional items on specific conditions, and the health professional's contained 24 general and 9 specific items. The construct of the questionnaires comprised a three-factor solution for patients and a five-factor solution for professionals. Principal component analysis with supplementary variables showed that patients with higher scores on ethical perception were associated with better opinions on health care quality and more confidence in professionals. In PHC professionals, higher scores were associated with effective knowledge of the code. Both questionnaires showed good psychometric properties and are valid to screen ethical attitudes. The instrument warrants further testing and use with culturally diverse patients and PHC professionals.

  19. Validation of OpenFoam for heavy gas dispersion applications.

    PubMed

    Mack, A; Spruijt, M P N

    2013-11-15

    In the present paper heavy gas dispersion calculations were performed with OpenFoam. For a wind tunnel test case, numerical data was validated with experiments. For a full scale numerical experiment, a code to code comparison was performed with numerical results obtained from Fluent. The validation was performed in a gravity driven environment (slope), where the heavy gas induced the turbulence. For the code to code comparison, a hypothetical heavy gas release into a strongly turbulent atmospheric boundary layer including terrain effects was selected. The investigations were performed for SF6 and CO2 as heavy gases applying the standard k-ɛ turbulence model. A strong interaction of the heavy gas with the turbulence is present which results in a strong damping of the turbulence and therefore reduced heavy gas mixing. Especially this interaction, based on the buoyancy effects, was studied in order to ensure that the turbulence-buoyancy coupling is the main driver for the reduced mixing and not the global behaviour of the turbulence modelling. For both test cases, comparisons were performed between OpenFoam and Fluent solutions which were mainly in good agreement with each other. Beside steady state solutions, the time accuracy was investigated. In the low turbulence environment (wind tunnel test) which for both codes (laminar solutions) was in good agreement, also with the experimental data. The turbulent solutions of OpenFoam were in much better agreement with the experimental results than the Fluent solutions. Within the strong turbulence environment, both codes showed an excellent comparability. Copyright © 2013 Elsevier B.V. All rights reserved.

  20. Hypersonic Experimental and Computational Capability, Improvement and Validation. Volume 2

    NASA Technical Reports Server (NTRS)

    Muylaert, Jean (Editor); Kumar, Ajay (Editor); Dujarric, Christian (Editor)

    1998-01-01

    The results of the phase 2 effort conducted under AGARD Working Group 18 on Hypersonic Experimental and Computational Capability, Improvement and Validation are presented in this report. The first volume, published in May 1996, mainly focused on the design methodology, plans and some initial results of experiments that had been conducted to serve as validation benchmarks. The current volume presents the detailed experimental and computational data base developed during this effort.

  1. Assessing the empirical validity of the "take-the-best" heuristic as a model of human probabilistic inference.

    PubMed

    Bröder, A

    2000-09-01

    The boundedly rational 'Take-The-Best" heuristic (TTB) was proposed by G. Gigerenzer, U. Hoffrage, and H. Kleinbölting (1991) as a model of fast and frugal probabilistic inferences. Although the simple lexicographic rule proved to be successful in computer simulations, direct empirical demonstrations of its adequacy as a psychological model are lacking because of several methodical problems. In 4 experiments with a total of 210 participants, this question was addressed. Whereas Experiment 1 showed that TTB is not valid as a universal hypothesis about probabilistic inferences, up to 28% of participants in Experiment 2 and 53% of participants in Experiment 3 were classified as TTB users. Experiment 4 revealed that investment costs for information seem to be a relevant factor leading participants to switch to a noncompensatory TTB strategy. The observed individual differences in strategy use imply the recommendation of an idiographic approach to decision-making research.

  2. Development of Valid and Reliable Measures of Patient and Family Experiences of Hospice Care for Public Reporting.

    PubMed

    Anhang Price, Rebecca; Stucky, Brian; Parast, Layla; Elliott, Marc N; Haas, Ann; Bradley, Melissa; Teno, Joan M

    2018-03-20

    Increasingly, dying patients and their families have a choice of hospice providers. Care quality varies considerably across providers; informing consumers of these differences may help to improve their selection of hospices. To develop and evaluate standardized survey measures of hospice care experiences for the purpose of comparing and publicly reporting hospice performance. We assessed item performance and constructed composite measures by factor analysis, evaluating item-scale correlations and estimating reliability. To assess key drivers of overall experiences, we regressed overall rating and willingness to recommend the hospice on each composite. Data submitted by 2500 hospices participating in national implementation of the Consumer Assessment of Healthcare Providers and Systems (CAHPS ® ) Hospice Survey for April through September 2015. Composite measures of Hospice Team Communication, Getting Timely Care, Treating Family Member with Respect, Getting Emotional and Religious Support, Getting Help for Symptoms, and Getting Hospice Care Training. Cronbach's alpha estimates for the composite measures range from 0.61 to 0.85; hospice-level reliability for the measures range from 0.67 to 0.81 assuming 200 completed surveys per hospice. Together, the composites are responsible for 48% of the variance in caregivers' overall ratings of hospices. Hospice Team Communication is the strongest predictor of overall rating of care. Our analyses provide evidence of the reliability and validity of CAHPS Hospice Survey measure scores. Results also highlight important opportunities to improve the quality of hospice care, particularly with regard to addressing symptoms of anxiety and sadness, discussing side effects of pain medicine, and keeping family informed of the patient's condition.

  3. Rover-based visual target tracking validation and mission infusion

    NASA Technical Reports Server (NTRS)

    Kim, Won S.; Steele, Robert D.; Ansar, Adnan I.; Ali, Khaled; Nesnas, Issa

    2005-01-01

    The Mars Exploration Rovers (MER'03), Spirit and Opportunity, represent the state of the art in rover operations on Mars. This paper presents validation experiments of different visual tracking algorithms using the rover's navigation camera.

  4. Electrically Driven Thermal Management: Flight Validation, Experiment Development, Future Technologies

    NASA Technical Reports Server (NTRS)

    Didion, Jeffrey R.

    2018-01-01

    Electrically Driven Thermal Management is an active research and technology development initiative incorporating ISS technology flight demonstrations (STP-H5), development of Microgravity Science Glovebox (MSG) flight experiment, and laboratory-based investigations of electrically based thermal management techniques. The program targets integrated thermal management for future generations of RF electronics and power electronic devices. This presentation reviews four program elements: i.) results from the Electrohydrodynamic (EHD) Long Term Flight Demonstration launched in February 2017 ii.) development of the Electrically Driven Liquid Film Boiling Experiment iii.) two University based research efforts iv.) development of Oscillating Heat Pipe evaluation at Goddard Space Flight Center.

  5. Development of a Two-fluid Drag Law for Clustered Particles using Direct Numerical Simulation and Validation through Experiments

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Gokaltun, Seckin; Munroe, Norman; Subramaniam, Shankar

    2014-12-31

    This study presents a new drag model, based on the cohesive inter-particle forces, implemented in the MFIX code. This new drag model combines an existing standard model in MFIX with a particle-based drag model based on a switching principle. Switches between the models in the computational domain occur where strong particle-to-particle cohesion potential is detected. Three versions of the new model were obtained by using one standard drag model in each version. Later, performance of each version was compared against available experimental data for a fluidized bed, published in the literature and used extensively by other researchers for validation purposes.more » In our analysis of the results, we first observed that standard models used in this research were incapable of producing closely matching results. Then, we showed for a simple case that a threshold is needed to be set on the solid volume fraction. This modification was applied to avoid non-physical results for the clustering predictions, when governing equation of the solid granular temperate was solved. Later, we used our hybrid technique and observed the capability of our approach in improving the numerical results significantly; however, improvement of the results depended on the threshold of the cohesive index, which was used in the switching procedure. Our results showed that small values of the threshold for the cohesive index could result in significant reduction of the computational error for all the versions of the proposed drag model. In addition, we redesigned an existing circulating fluidized bed (CFB) test facility in order to create validation cases for clustering regime of Geldart A type particles.« less

  6. Reliability and Validity of Prototype Diagnosis for Adolescent Psychopathology.

    PubMed

    Haggerty, Greg; Zodan, Jennifer; Mehra, Ashwin; Zubair, Ayyan; Ghosh, Krishnendu; Siefert, Caleb J; Sinclair, Samuel J; DeFife, Jared

    2016-04-01

    The current study investigated the interrater reliability and validity of prototype ratings of 5 common adolescent psychiatric disorders: attention-deficit/hyperactivity disorder, conduct disorder, major depressive disorder, generalized anxiety disorder, and posttraumatic stress disorder. One hundred fifty-seven adolescent inpatient participants consented to participate in this study. We compared ratings from 2 inpatient clinicians, blinded to each other's ratings and patient measures, after their separate initial diagnostic interview to assess interrater reliability. Prototype ratings completed by clinicians after their initial diagnostic interview with adolescent inpatients and outpatients were compared with patient-reported behavior problems and parents' report of their child's behavioral problems. Prototype ratings demonstrated good interrater reliability. Clinicians' prototype ratings showed predicted relationships with patient-reported behavior problems and parent-reported behavior problems. Prototype matching seems to be a possible alternative for psychiatric diagnosis. Prototype ratings showed good interrater reliability based on clinicians unique experiences with the patient (as opposed to video-/audio-recorded material) with no training.

  7. Experimental validation of a millimeter wave radar technique to remotely sense atmospheric pressure at the Earth's surface

    NASA Technical Reports Server (NTRS)

    Flower, D. A.; Peckham, G. E.; Bradford, W. J.

    1984-01-01

    Experiments with a millimeter wave radar operating on the NASA CV-990 aircraft which validate the technique for remotely sensing atmospheric pressure at the Earth's surface are described. Measurements show that the precise millimeter wave observations needed to deduce pressure from space with an accuracy of 1 mb are possible, that sea surface reflection properties agree with theory and that the measured variation of differential absorption with altitude corresponds to that expected from spectroscopic models.

  8. Integrated Disposal Facility FY 2016: ILAW Verification and Validation of the eSTOMP Simulator

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Freedman, Vicky L.; Bacon, Diana H.; Fang, Yilin

    2016-05-13

    This document describes two sets of simulations carried out to further verify and validate the eSTOMP simulator. In this report, a distinction is made between verification and validation, and the focus is on verifying eSTOMP through a series of published benchmarks on cementitious wastes, and validating eSTOMP based on a lysimeter experiment for the glassified waste. These activities are carried out within the context of a scientific view of validation that asserts that models can only be invalidated, and that model validation (and verification) is a subjective assessment.

  9. The New Millennium Program: Validating Advanced Technologies for Future Space Missions

    NASA Technical Reports Server (NTRS)

    Minning, Charles P.; Luers, Philip

    1999-01-01

    This presentation reviews the activities of the New Millennium Program (NMP) in validating advanced technologies for space missions. The focus of these breakthrough technologies are to enable new capabilities to fulfill the science needs, while reducing costs of future missions. There is a broad spectrum of NMP partners, including government agencies, universities and private industry. The DS-1 was launched on October 24, 1998. Amongst the technologies validated by the NMP on DS-1 are: a Low Power Electronics Experiment, the Power Activation and Switching Module, Multi-Functional Structures. The first two of these technologies are operational and the data analysis is still ongoing. The third program is also operational, and its performance parameters have been verified. The second program, DS-2, was launched January 3 1999. It is expected to impact near Mars southern polar region on 3 December 1999. The technologies used on this mission awaiting validation are an advanced microcontroller, a power microelectronics unit, an evolved water experiment and soil thermal conductivity experiment, Lithium-Thionyl Chloride batteries, the flexible cable interconnect, aeroshell/entry system, and a compact telecom system. EO-1 on schedule for launch in December 1999 carries several technologies to be validated. Amongst these are: a Carbon-Carbon Radiator, an X-band Phased Array Antenna, a pulsed plasma thruster, a wideband advanced recorder processor, an atmospheric corrector, lightweight flexible solar arrays, Advanced Land Imager and the Hyperion instrument

  10. Design and validation of a three-instrument toolkit for the assessment of competence in electrocardiogram rhythm recognition.

    PubMed

    Hernández-Padilla, José M; Granero-Molina, José; Márquez-Hernández, Verónica V; Suthers, Fiona; López-Entrambasaguas, Olga M; Fernández-Sola, Cayetano

    2017-06-01

    Rapid and accurate interpretation of cardiac arrhythmias by nurses has been linked with safe practice and positive patient outcomes. Although training in electrocardiogram rhythm recognition is part of most undergraduate nursing programmes, research continues to suggest that nurses and nursing students lack competence in recognising cardiac rhythms. In order to promote patient safety, nursing educators must develop valid and reliable assessment tools that allow the rigorous assessment of this competence before nursing students are allowed to practise without supervision. The aim of this study was to develop and psychometrically evaluate a toolkit to holistically assess competence in electrocardiogram rhythm recognition. Following a convenience sampling technique, 293 nursing students from a nursing faculty in a Spanish university were recruited for the study. The following three instruments were developed and psychometrically tested: an electrocardiogram knowledge assessment tool (ECG-KAT), an electrocardiogram skills assessment tool (ECG-SAT) and an electrocardiogram self-efficacy assessment tool (ECG-SES). Reliability and validity (content, criterion and construct) of these tools were meticulously examined. A high Cronbach's alpha coefficient demonstrated the excellent reliability of the instruments (ECG-KAT=0.89; ECG-SAT=0.93; ECG-SES=0.98). An excellent context validity index (scales' average content validity index>0.94) and very good criterion validity were evidenced for all the tools. Regarding construct validity, principal component analysis revealed that all items comprising the instruments contributed to measure knowledge, skills or self-efficacy in electrocardiogram rhythm recognition. Moreover, known-groups analysis showed the tools' ability to detect expected differences in competence between groups with different training experiences. The three-instrument toolkit developed showed excellent psychometric properties for measuring competence in

  11. Development and Validation of Videotaped Scenarios

    PubMed Central

    Noel, Nora E.; Maisto, Stephen A.; Johnson, James D.; Jackson, Lee A.; Goings, Christopher D.; Hagman, Brett T.

    2013-01-01

    Researchers using scenarios often neglect to validate perceived content and salience of embedded stimuli specifically with intended participants, even when such meaning is integral to the study. For example, sex and aggression stimuli are heavily influenced by culture, so participants may not perceive what researchers intended in sexual aggression scenarios. Using four studies, the authors describe the method of scenario validation to produce two videos assessing alcohol-related sexual aggression. Both videos are identical except for the presence in one video of antiforce cues that are extremely salient to the young heterosexual men. Focus groups and questionnaires validate these men's perceptions that (a) the woman was sexually interested, (b) the sexual cues were salient, (c) the antiforce cues were salient (antiaggression video only), and (e) these antiforce cues inhibited acceptance of forced sex. Results show the value of carefully selecting and validating content when assessing socially volatile variables and provide a useful template for developing culturally valid scenarios. PMID:18252938

  12. Development and validation of a two-dimensional fast-response flood estimation model

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Judi, David R; Mcpherson, Timothy N; Burian, Steven J

    2009-01-01

    A finite difference formulation of the shallow water equations using an upwind differencing method was developed maintaining computational efficiency and accuracy such that it can be used as a fast-response flood estimation tool. The model was validated using both laboratory controlled experiments and an actual dam breach. Through the laboratory experiments, the model was shown to give good estimations of depth and velocity when compared to the measured data, as well as when compared to a more complex two-dimensional model. Additionally, the model was compared to high water mark data obtained from the failure of the Taum Sauk dam. Themore » simulated inundation extent agreed well with the observed extent, with the most notable differences resulting from the inability to model sediment transport. The results of these validation studies complex two-dimensional model. Additionally, the model was compared to high water mark data obtained from the failure of the Taum Sauk dam. The simulated inundation extent agreed well with the observed extent, with the most notable differences resulting from the inability to model sediment transport. The results of these validation studies show that a relatively numerical scheme used to solve the complete shallow water equations can be used to accurately estimate flood inundation. Future work will focus on further reducing the computation time needed to provide flood inundation estimates for fast-response analyses. This will be accomplished through the efficient use of multi-core, multi-processor computers coupled with an efficient domain-tracking algorithm, as well as an understanding of the impacts of grid resolution on model results.« less

  13. CFD Validation with Experiment and Verification with Physics of a Propellant Damping Device

    NASA Technical Reports Server (NTRS)

    Yang, H. Q.; Peugeot, John

    2011-01-01

    This paper will document our effort in validating a coupled fluid-structure interaction CFD tool in predicting a damping device performance in the laboratory condition. Consistently good comparisons of "blind" CFD predictions against experimental data under various operation conditions, design parameters, and cryogenic environment will be presented. The power of the coupled CFD-structures interaction code in explaining some unexpected phenomena of the device observed during the technology development will be illustrated. The evolution of the damper device design inside the LOX tank will be used to demonstrate the contribution of the tool in understanding, optimization and implementation of LOX damper in Ares I vehicle. It is due to the present validation effort, the LOX damper technology has matured to TRL 5. The present effort has also contributed to the transition of the technology from an early conceptual observation to the baseline design of thrust oscillation mitigation for the Ares I within a 10 month period.

  14. Rediscovery rate estimation for assessing the validation of significant findings in high-throughput studies.

    PubMed

    Ganna, Andrea; Lee, Donghwan; Ingelsson, Erik; Pawitan, Yudi

    2015-07-01

    It is common and advised practice in biomedical research to validate experimental or observational findings in a population different from the one where the findings were initially assessed. This practice increases the generalizability of the results and decreases the likelihood of reporting false-positive findings. Validation becomes critical when dealing with high-throughput experiments, where the large number of tests increases the chance to observe false-positive results. In this article, we review common approaches to determine statistical thresholds for validation and describe the factors influencing the proportion of significant findings from a 'training' sample that are replicated in a 'validation' sample. We refer to this proportion as rediscovery rate (RDR). In high-throughput studies, the RDR is a function of false-positive rate and power in both the training and validation samples. We illustrate the application of the RDR using simulated data and real data examples from metabolomics experiments. We further describe an online tool to calculate the RDR using t-statistics. We foresee two main applications. First, if the validation study has not yet been collected, the RDR can be used to decide the optimal combination between the proportion of findings taken to validation and the size of the validation study. Secondly, if a validation study has already been done, the RDR estimated using the training data can be compared with the observed RDR from the validation data; hence, the success of the validation study can be assessed. © The Author 2014. Published by Oxford University Press. For Permissions, please email: journals.permissions@oup.com.

  15. MODELS FOR SUBMARINE OUTFALL - VALIDATION AND PREDICTION UNCERTAINTIES

    EPA Science Inventory

    This address reports on some efforts to verify and validate dilution models, including those found in Visual Plumes. This is done in the context of problem experience: a range of problems, including different pollutants such as bacteria; scales, including near-field and far-field...

  16. Validation and Error Characterization for the Global Precipitation Measurement

    NASA Technical Reports Server (NTRS)

    Bidwell, Steven W.; Adams, W. J.; Everett, D. F.; Smith, E. A.; Yuter, S. E.

    2003-01-01

    The Global Precipitation Measurement (GPM) is an international effort to increase scientific knowledge on the global water cycle with specific goals of improving the understanding and the predictions of climate, weather, and hydrology. These goals will be achieved through several satellites specifically dedicated to GPM along with the integration of numerous meteorological satellite data streams from international and domestic partners. The GPM effort is led by the National Aeronautics and Space Administration (NASA) of the United States and the National Space Development Agency (NASDA) of Japan. In addition to the spaceborne assets, international and domestic partners will provide ground-based resources for validating the satellite observations and retrievals. This paper describes the validation effort of Global Precipitation Measurement to provide quantitative estimates on the errors of the GPM satellite retrievals. The GPM validation approach will build upon the research experience of the Tropical Rainfall Measuring Mission (TRMM) retrieval comparisons and its validation program. The GPM ground validation program will employ instrumentation, physical infrastructure, and research capabilities at Supersites located in important meteorological regimes of the globe. NASA will provide two Supersites, one in a tropical oceanic and the other in a mid-latitude continental regime. GPM international partners will provide Supersites for other important regimes. Those objectives or regimes not addressed by Supersites will be covered through focused field experiments. This paper describes the specific errors that GPM ground validation will address, quantify, and relate to the GPM satellite physical retrievals. GPM will attempt to identify the source of errors within retrievals including those of instrument calibration, retrieval physical assumptions, and algorithm applicability. With the identification of error sources, improvements will be made to the respective calibration

  17. Validation in the Absence of Observed Events

    DOE PAGES

    Lathrop, John; Ezell, Barry

    2015-07-22

    Here our paper addresses the problem of validating models in the absence of observed events, in the area of Weapons of Mass Destruction terrorism risk assessment. We address that problem with a broadened definition of “Validation,” based on “backing up” to the reason why modelers and decision makers seek validation, and from that basis re-define validation as testing how well the model can advise decision makers in terrorism risk management decisions. We develop that into two conditions: Validation must be based on cues available in the observable world; and it must focus on what can be done to affect thatmore » observable world, i.e. risk management. That in turn leads to two foci: 1.) the risk generating process, 2.) best use of available data. Based on our experience with nine WMD terrorism risk assessment models, we then describe three best use of available data pitfalls: SME confidence bias, lack of SME cross-referencing, and problematic initiation rates. Those two foci and three pitfalls provide a basis from which we define validation in this context in terms of four tests -- Does the model: … capture initiation? … capture the sequence of events by which attack scenarios unfold? … consider unanticipated scenarios? … consider alternative causal chains? Finally, we corroborate our approach against three key validation tests from the DOD literature: Is the model a correct representation of the simuland? To what degree are the model results comparable to the real world? Over what range of inputs are the model results useful?« less

  18. Validation in the Absence of Observed Events.

    PubMed

    Lathrop, John; Ezell, Barry

    2016-04-01

    This article addresses the problem of validating models in the absence of observed events, in the area of weapons of mass destruction terrorism risk assessment. We address that problem with a broadened definition of "validation," based on stepping "up" a level to considering the reason why decisionmakers seek validation, and from that basis redefine validation as testing how well the model can advise decisionmakers in terrorism risk management decisions. We develop that into two conditions: validation must be based on cues available in the observable world; and it must focus on what can be done to affect that observable world, i.e., risk management. That leads to two foci: (1) the real-world risk generating process, and (2) best use of available data. Based on our experience with nine WMD terrorism risk assessment models, we then describe three best use of available data pitfalls: SME confidence bias, lack of SME cross-referencing, and problematic initiation rates. Those two foci and three pitfalls provide a basis from which we define validation in this context in terms of four tests--Does the model: … capture initiation? … capture the sequence of events by which attack scenarios unfold? … consider unanticipated scenarios? … consider alternative causal chains? Finally, we corroborate our approach against three validation tests from the DOD literature: Is the model a correct representation of the process to be simulated? To what degree are the model results comparable to the real world? Over what range of inputs are the model results useful? © 2015 Society for Risk Analysis.

  19. Validation of the Persian version of the Daily Spiritual Experiences Scale (DSES) in Pregnant Women: A Proper Tool to Assess Spirituality Related to Mental Health.

    PubMed

    Saffari, Mohsen; Amini, Hossein; Sheykh-Oliya, Zarindokht; Pakpour, Amir H; Koenig, Harold G

    2017-12-01

    Assessing spirituality in healthy pregnant women may lead to supportive interventions that will improve their care. A psychometrically valid measure such as the Daily Spiritual Experiences Scale (DSES) may be helpful in this regard. The current study sought to adapt a Persian version of DSES for use in pregnancy. A total of 377 pregnant women were recruited from three general hospitals located in Tehran, Iran. Administered scales were the DSES, Duke University Religion Index, Santa Clara Strength of Religious Faith scale, and Depression Anxiety Stress Scale, as well as demographic measures. Reliability of the DSES was tested using Cronbach's alpha for internal consistency and the intraclass correlation coefficient (ICC) for test-retest stability. Scale validity was assessed by criterion-related tests, known-groups comparison, and exploratory factor analysis. Participant's mean age was 27.7 (4.1), and most were nulliparous (70%). The correlation coefficient between individual items on the scale and the total score was greater than 0.30 in most cases. Cronbach's alpha for the scale was 0.90. The ICC for 2-week test-retest reliability was high (0.86). Relationships between similar and dissimilar scales indicated acceptable convergent and divergent validity. The factor structure of the scale indicated a single factor that explained 59% of the variance. The DSES was found to be a reliable and valid measure of spirituality in pregnant Iranian women. This scale may be used to examine the relationship between spirituality and health outcomes, research that may lead to supportive interventions in this population.

  20. MRPrimerW: a tool for rapid design of valid high-quality primers for multiple target qPCR experiments.

    PubMed

    Kim, Hyerin; Kang, NaNa; An, KyuHyeon; Koo, JaeHyung; Kim, Min-Soo

    2016-07-08

    Design of high-quality primers for multiple target sequences is essential for qPCR experiments, but is challenging due to the need to consider both homology tests on off-target sequences and the same stringent filtering constraints on the primers. Existing web servers for primer design have major drawbacks, including requiring the use of BLAST-like tools for homology tests, lack of support for ranking of primers, TaqMan probes and simultaneous design of primers against multiple targets. Due to the large-scale computational overhead, the few web servers supporting homology tests use heuristic approaches or perform homology tests within a limited scope. Here, we describe the MRPrimerW, which performs complete homology testing, supports batch design of primers for multi-target qPCR experiments, supports design of TaqMan probes and ranks the resulting primers to return the top-1 best primers to the user. To ensure high accuracy, we adopted the core algorithm of a previously reported MapReduce-based method, MRPrimer, but completely redesigned it to allow users to receive query results quickly in a web interface, without requiring a MapReduce cluster or a long computation. MRPrimerW provides primer design services and a complete set of 341 963 135 in silico validated primers covering 99% of human and mouse genes. Free access: http://MRPrimerW.com. © The Author(s) 2016. Published by Oxford University Press on behalf of Nucleic Acids Research.