Cognitive Diagnostic Analysis Using Hierarchically Structured Skills

ERIC Educational Resources Information Center

Su, Yu-Lan

2013-01-01

This dissertation proposes two modified cognitive diagnostic models (CDMs), the deterministic, inputs, noisy, "and" gate with hierarchy (DINA-H) model and the deterministic, inputs, noisy, "or" gate with hierarchy (DINO-H) model. Both models incorporate the hierarchical structures of the cognitive skills in the model estimation…

Cognitive diagnosis modelling incorporating item response times.

PubMed

Zhan, Peida; Jiao, Hong; Liao, Dandan

2018-05-01

To provide more refined diagnostic feedback with collateral information in item response times (RTs), this study proposed joint modelling of attributes and response speed using item responses and RTs simultaneously for cognitive diagnosis. For illustration, an extended deterministic input, noisy 'and' gate (DINA) model was proposed for joint modelling of responses and RTs. Model parameter estimation was explored using the Bayesian Markov chain Monte Carlo (MCMC) method. The PISA 2012 computer-based mathematics data were analysed first. These real data estimates were treated as true values in a subsequent simulation study. A follow-up simulation study with ideal testing conditions was conducted as well to further evaluate model parameter recovery. The results indicated that model parameters could be well recovered using the MCMC approach. Further, incorporating RTs into the DINA model would improve attribute and profile correct classification rates and result in more accurate and precise estimation of the model parameters. © 2017 The British Psychological Society.

Electronic and optical properties of graphene-like InAs: An ab initio study

NASA Astrophysics Data System (ADS)

Sohrabi, Leila; Boochani, Arash; Ali Sebt, S.; Mohammad Elahi, S.

2018-03-01

The present work initially investigates structural, optical, and electronic properties of graphene-like InAs by using the full potential linear augmented plane wave method in the framework of density functional theory and is then compared with the bulk Indium Arsenide in the wurtzite phase. The lattice parameters are optimized with GGA-PBE and LDA approximations for both 2D- and 3D-InAs. In order to study the electronic properties of graphene-like InAs and bulk InAs in the wurtzite phase, the band gap is calculated by GGA-PBG and GGA-EV approximations. Moreover, optical parameters of graphene-like InAs and bulk InAs such as the real and imaginary parts of dielectric function, electron energy loss function, refractivity, extinction and absorption coefficients, and optical conductivity are investigated. Plasmonic frequencies of 2D- and 3D-InAs are also calculated by using maximum electron energy loss function and the roots of the real part of the dielectric function.

Statistical Analysis of Q-matrix Based Diagnostic Classification Models

PubMed Central

Chen, Yunxiao; Liu, Jingchen; Xu, Gongjun; Ying, Zhiliang

2014-01-01

Diagnostic classification models have recently gained prominence in educational assessment, psychiatric evaluation, and many other disciplines. Central to the model specification is the so-called Q-matrix that provides a qualitative specification of the item-attribute relationship. In this paper, we develop theories on the identifiability for the Q-matrix under the DINA and the DINO models. We further propose an estimation procedure for the Q-matrix through the regularized maximum likelihood. The applicability of this procedure is not limited to the DINA or the DINO model and it can be applied to essentially all Q-matrix based diagnostic classification models. Simulation studies are conducted to illustrate its performance. Furthermore, two case studies are presented. The first case is a data set on fraction subtraction (educational application) and the second case is a subsample of the National Epidemiological Survey on Alcohol and Related Conditions concerning the social anxiety disorder (psychiatric application). PMID:26294801

The Concept of "English Learning Power" and Its Implication for the Design of English Curricula for Primary and Middle Schools in China

ERIC Educational Resources Information Center

Dai, Zhongxin

2015-01-01

In the research on "New Characteristics of Future Basic Education in China," Dina Pei formulates a "three-powered" model to theorize about the characteristics of future basic education in China. The three powers refer to the "Policy-making Power" of the local educational administration, the "Leading Power"…

Disintegration in Peru - Consolidation in Chile: The Case for Militant Capitalism in Latin America

DTIC Science & Technology

1990-06-01

organization Comision Chilena de Derechos Humanos (CCDH), (which along with the Church-sponsored Vicaria de la Solaridad are the principal watchdog...34 reported by Chile’s human rights group Comision de Desechos Humanos (CCDH), the majority reflect a particular 134 period in time during which DINA was the

The New Voices = Nuevas Voces Guide to Cultural and Linguistic Diversity in Early Childhood/The New Voices = Nuevas Voces Facilitator's Guide to Cultural and Linguistic Diversity in Early Childhood

ERIC Educational Resources Information Center

Castro, Dina C.; Ayankoya, Betsy; Kasprzak, Christina

2011-01-01

As early childhood programs and schools become more culturally and linguistically diverse, professionals need to create settings that welcome "new voices" and help all children succeed. This comprehensive professional development course gives them the in-depth practical guidance they need. Developed by respected scholar Dina Castro and her expert…

Study of Globus-M Tokamak Poloidal System and Plasma Position Control

NASA Astrophysics Data System (ADS)

Dokuka, V. N.; Korenev, P. S.; Mitrishkin, Yu. V.; Pavlova, E. A.; Patrov, M. I.; Khayrutdinov, R. R.

2017-12-01

In order to provide efficient performance of tokamaks with vertically elongated plasma position, control systems for limited and diverted plasma configuration are required. The accuracy, stability, speed of response, and reliability of plasma position control as well as plasma shape and current control depend on the performance of the control system. Therefore, the problem of the development of such systems is an important and actual task in modern tokamaks. In this study, the measured signals from the magnetic loops and Rogowski coils are used to reconstruct the plasma equilibrium, for which linear models in small deviations are constructed. We apply methods of the H∞-optimization theory to the synthesize control system for vertical and horizontal position of plasma capable to working with structural uncertainty of the models of the plant. These systems are applied to the plasma-physical DINA code which is configured for the tokamak Globus-M plasma. The testing of the developed systems applied to the DINA code with Heaviside step functions have revealed the complex dynamics of plasma magnetic configurations. Being close to the bifurcation point in the parameter space of unstable plasma has made it possible to detect an abrupt change in the X-point position from the top to the bottom and vice versa. Development of the methods for reconstruction of plasma magnetic configurations and experience in designing plasma control systems with feedback for tokamaks provided an opportunity to synthesize new digital controllers for plasma vertical and horizontal position stabilization. It also allowed us to test the synthesized digital controllers in the closed loop of the control system with the DINA code as a nonlinear model of plasma.

Serious ESL Lessons Await Students In The Funny Pages

ERIC Educational Resources Information Center

Curriculum Review, 2005

2005-01-01

This brief article discusses how carefully selected comic strips can become great teaching aids for (English Second Language) ESL instructors. They are beneficial in part because they provide brief conversations in English with pictures that help convey the meaning of the words. ESL teacher Dina Dahbany-Miraglia, author of Speaking American…

Application of a Cognitive Diagnostic Model to a High-Stakes Reading Comprehension Test

ERIC Educational Resources Information Center

Ravand, Hamdollah

2016-01-01

General cognitive diagnostic models (CDM) such as the generalized deterministic input, noisy, "and" gate (G-DINA) model are flexible in that they allow for both compensatory and noncompensatory relationships among the subskills within the same test. Most of the previous CDM applications in the literature have been add-ons to simulation…

DINA Model and Parameter Estimation: A Didactic

ERIC Educational Resources Information Center

de la Torre, Jimmy

2009-01-01

Cognitive and skills diagnosis models are psychometric models that have immense potential to provide rich information relevant for instruction and learning. However, wider applications of these models have been hampered by their novelty and the lack of commercially available software that can be used to analyze data from this psychometric…

A Latent Transition Analysis Model for Assessing Change in Cognitive Skills

ERIC Educational Resources Information Center

Li, Feiming; Cohen, Allan; Bottge, Brian; Templin, Jonathan

2016-01-01

Latent transition analysis (LTA) was initially developed to provide a means of measuring change in dynamic latent variables. In this article, we illustrate the use of a cognitive diagnostic model, the DINA model, as the measurement model in a LTA, thereby demonstrating a means of analyzing change in cognitive skills over time. An example is…

jsc2013e100869

NASA Image and Video Library

2013-12-24

DATE: 12-24-13 LOCATION: Bldg. 30 - FCR-1 (30M/231) SUBJECT: ISS Flight Controllers during Expedition 38's 2nd Spacewalk to repair a faulty ISS Coolant pump with Astronauts Rick Mastracchio and Mike Hopkins. Flight Director: Dina Contella, Capcom's Doug Wheelock, Aki Hoshide, and Lead U.S. Spacewalk Officer Allison Bolinger. PHOTOGRAPHER: Lauren Harnett

jsc2013e100852

NASA Image and Video Library

2013-12-24

DATE: 12-24-13 LOCATION: Bldg. 30 - FCR-1 (30M/231) SUBJECT: ISS Flight Controllers during Expedition 38's 2nd Spacewalk to repair a faulty ISS Coolant pump with Astronauts Rick Mastracchio and Mike Hopkins. Flight Director: Dina Contella, Capcom's Doug Wheelock, Aki Hoshide, and Lead U.S. Spacewalk Officer Allison Bolinger. PHOTOGRAPHER: Lauren Harnett

jsc2013e100718

NASA Image and Video Library

2013-12-21

Photo Date: 12/21/2013 Location: Bldg. 30 - FCR-1 (30M/231 Subject: ISS Flight Controllers during Expedition 38's 1st Spacewalk to repair a faulty ISS Coolant pump with Astronauts Rick Mastracchio and Mike Hopkins. Flight Director: Dina Contella, Capcom's Doug Wheelock, Aki Hoshide, and Lead U.S. Spacewalk Officer Allison Bolinger. Photographer: Robert Markowitz

jsc2013e100844

NASA Image and Video Library

2013-12-24

DATE: 12-24-13 LOCATION: Bldg. 30 - FCR-1 (30M/231) SUBJECT: ISS Flight Controllers during Expedition 38's 2nd Spacewalk to repair a faulty ISS Coolant pump with Astronauts Rick Mastracchio and Mike Hopkins. Flight Director: Dina Contella, Capcom's Doug Wheelock, Aki Hoshide, and Lead U.S. Spacewalk Officer Allison Bolinger. PHOTOGRAPHER: Lauren Harnett

jsc2013e100870

NASA Image and Video Library

2013-12-24

DATE: 12-24-13 LOCATION: Bldg. 30 - FCR-1 (30M/231) SUBJECT: ISS Flight Controllers during Expedition 38's 2nd Spacewalk to repair a faulty ISS Coolant pump with Astronauts Rick Mastracchio and Mike Hopkins. Flight Director: Dina Contella, Capcom's Doug Wheelock, Aki Hoshide, and Lead U.S. Spacewalk Officer Allison Bolinger. PHOTOGRAPHER: Lauren Harnett

jsc2013e100843

NASA Image and Video Library

2013-12-24

DATE: 12-24-13 LOCATION: Bldg. 30 - FCR-1 (30M/231) SUBJECT: ISS Flight Controllers during Expedition 38's 2nd Spacewalk to repair a faulty ISS Coolant pump with Astronauts Rick Mastracchio and Mike Hopkins. Flight Director: Dina Contella, Capcom's Doug Wheelock, Aki Hoshide, and Lead U.S. Spacewalk Officer Allison Bolinger. PHOTOGRAPHER: Lauren Harnett

jsc2013e100695

NASA Image and Video Library

2013-12-21

Photo Date: 12/21/2013 Location: Bldg. 30 - FCR-1 (30M/231 Subject: ISS Flight Controllers during Expedition 38's 1st Spacewalk to repair a faulty ISS Coolant pump with Astronauts Rick Mastracchio and Mike Hopkins. Flight Director: Dina Contella, Capcom's Doug Wheelock, Aki Hoshide, and Lead U.S. Spacewalk Officer Allison Bolinger. Photographer: Robert Markowitz

jsc2013e100867

NASA Image and Video Library

2013-12-24

DATE: 12-24-13 LOCATION: Bldg. 30 - FCR-1 (30M/231) SUBJECT: ISS Flight Controllers during Expedition 38's 2nd Spacewalk to repair a faulty ISS Coolant pump with Astronauts Rick Mastracchio and Mike Hopkins. Flight Director: Dina Contella, Capcom's Doug Wheelock, Aki Hoshide, and Lead U.S. Spacewalk Officer Allison Bolinger. PHOTOGRAPHER: Lauren Harnett

jsc2013e100827

NASA Image and Video Library

2013-12-24

DATE: 12-24-13 LOCATION: Bldg. 30 - FCR-1 (30M/231) SUBJECT: ISS Flight Controllers during Expedition 38's 2nd Spacewalk to repair a faulty ISS Coolant pump with Astronauts Rick Mastracchio and Mike Hopkins. Flight Director: Dina Contella, Capcom's Doug Wheelock, Aki Hoshide, and Lead U.S. Spacewalk Officer Allison Bolinger. PHOTOGRAPHER: Lauren Harnett

jsc2013e100873

NASA Image and Video Library

2013-12-24

DATE: 12-24-13 LOCATION: Bldg. 30 - FCR-1 (30M/231) SUBJECT: ISS Flight Controllers during Expedition 38's 2nd Spacewalk to repair a faulty ISS Coolant pump with Astronauts Rick Mastracchio and Mike Hopkins. Flight Director: Dina Contella, Capcom's Doug Wheelock, Aki Hoshide, and Lead U.S. Spacewalk Officer Allison Bolinger. PHOTOGRAPHER: Lauren Harnett

jsc2013e100855

NASA Image and Video Library

2013-12-24

DATE: 12-24-13 LOCATION: Bldg. 30 - FCR-1 (30M/231) SUBJECT: ISS Flight Controllers during Expedition 38's 2nd Spacewalk to repair a faulty ISS Coolant pump with Astronauts Rick Mastracchio and Mike Hopkins. Flight Director: Dina Contella, Capcom's Doug Wheelock, Aki Hoshide, and Lead U.S. Spacewalk Officer Allison Bolinger. PHOTOGRAPHER: Lauren Harnett

jsc2013e100685

NASA Image and Video Library

2013-12-21

Photo Date: 12/21/2013 Location: Bldg. 30 - FCR-1 (30M/231 Subject: ISS Flight Controllers during Expedition 38's 1st Spacewalk to repair a faulty ISS Coolant pump with Astronauts Rick Mastracchio and Mike Hopkins. Flight Director: Dina Contella, Capcom's Doug Wheelock, Aki Hoshide, and Lead U.S. Spacewalk Officer Allison Bolinger. Photographer: Robert Markowitz

jsc2013e100831

NASA Image and Video Library

2013-12-24

DATE: 12-24-13 LOCATION: Bldg. 30 - FCR-1 (30M/231) SUBJECT: ISS Flight Controllers during Expedition 38's 2nd Spacewalk to repair a faulty ISS Coolant pump with Astronauts Rick Mastracchio and Mike Hopkins. Flight Director: Dina Contella, Capcom's Doug Wheelock, Aki Hoshide, and Lead U.S. Spacewalk Officer Allison Bolinger. PHOTOGRAPHER: Lauren Harnett

Diagnostic Models as Partially Ordered Sets

ERIC Educational Resources Information Center

Tatsuoka, Curtis

2009-01-01

In this commentary, the author addresses what is referred to as the deterministic input, noisy "and" gate (DINA) model. The author mentions concerns with how this model has been formulated and presented. In particular, the author points out that there is a lack of recognition of the confounding of profiles that generally arises and then discusses…

Disruption forces on the tokamak wall with and without poloidal currents

NASA Astrophysics Data System (ADS)

Pustovitov, V. D.

2017-05-01

The contributions into the disruption radial force on the tokamak vacuum vessel wall are calculated and analyzed. One is due to the induced toroidal current in the wall, and another is due to the poloidal current. The latter is not accounted for in the models that represent the wall as a set of isolated toroidal filaments. It is shown that such modeling must lead to significant errors in the evaluation of the force during either thermal or current quench. The analytical derivations are performed here for an arbitrary tokamak configuration with final estimates for a circular large-aspect-ratio plasma and a coaxial wall reacting on perturbations as a perfect conductor. The results are compared with those recently obtained numerically by the codes DINA, MAXFEA and CarMa0NL. The discrepancies between the DINA simulations (Khayrutdinov et al 2016 Plasma Phys. Control. Fusion 58 115012) and earlier analytical predictions are explained. The recent conclusion (Villone et al 2015 Fusion Eng. Des. 93 57) on the role of the disruption-induced poloidal current in the wall is confirmed and extended to a wider area.

Application of cognitive diagnosis models to competency-based situational judgment tests.

PubMed

García, Pablo Eduardo; Olea, Julio; De la Torre, Jimmy

2014-01-01

Profiling of jobs in terms of competency requirements has increasingly been applied in many organizational settings. Testing these competencies through situational judgment tests (SJTs) leads to validity problems because it is not usually clear which constructs SJTs measure. The primary purpose of this paper is to evaluate whether the application of cognitive diagnosis models (CDM) to competency-based SJTs can ascertain the underlying competencies measured by the items, and whether these competencies can be estimated precisely. The generalized deterministic inputs, noisy "and" gate (G-DINA) model was applied to 26 situational judgment items measuring professional competencies based on the great eight model. These items were applied to 485 employees of a Spanish financial company. The fit of the model to the data and the convergent validity between the estimated competencies and personality dimensions were examined. The G-DINA showed a good fit to the data and the estimated competency factors, adapting and coping and interacting and presenting were positively related to emotional stability and extraversion, respectively. This work indicates that CDM can be a useful tool when measuring professional competencies through SJTs. CDM can clarify the competencies being measured and provide precise estimates of these competencies.

Evaluating the Wald Test for Item-Level Comparison of Saturated and Reduced Models in Cognitive Diagnosis

ERIC Educational Resources Information Center

de la Torre, Jimmy; Lee, Young-Sun

2013-01-01

This article used the Wald test to evaluate the item-level fit of a saturated cognitive diagnosis model (CDM) relative to the fits of the reduced models it subsumes. A simulation study was carried out to examine the Type I error and power of the Wald test in the context of the G-DINA model. Results show that when the sample size is small and a…

Impact of Hypobarism During Simulated Transport on Critical Care Air Transport Team Performance

DTIC Science & Technology

2017-04-26

AFRL-SA-WP-SR-2017-0008 Impact of Hypobarism During Simulated Transport on Critical Care Air Transport Team Performance Dina...July 2014 – November 2016 4. TITLE AND SUBTITLE Impact of Hypobarism During Simulated Transport on Critical Care Air Transport Team Performance 5a...During Critical Care Air Transport Team Advanced Course validation, three-member teams consisting of a physician, nurse, and respiratory therapist

The Effect of Bilingual Term List Size on Dictionary-Based Cross-Language Information Retrieval

DTIC Science & Technology

2006-01-01

The Effect of Bilingual Term List Size on Dictionary -Based Cross-Language Information Retrieval Dina Demner-Fushman Department of Computer Science... dictionary -based Cross-Language Information Retrieval (CLIR), in which the goal is to find documents written in one natural language based on queries that...in which the documents are written. In dictionary -based CLIR techniques, the princi- pal source of translation knowledge is a translation lexicon

United States Marine Corps Career Designation Board: Significant Factors in Predicting Selection

DTIC Science & Technology

2014-03-01

estimate or any other aspect of this collection of information, including suggestions for reducing this burden, to Washington headquarters Services...Advisor Dina Shatnawi Second Reader William Gates Dean, Graduate School of Business and Public Policy iv THIS PAGE INTENTIONALLY...but also do it in a way that would be easiest for me to use. Doreen assisted in extracting the necessary FITREP data, which added significant value

A Randomized, Controlled Trial of Intranasal Oxytocin as an Adjunct to Behavioral Therapy for Autism Spectrum Disorder

DTIC Science & Technology

2015-10-01

Fellowship of the Alexander von Humboldt Foundation , MIT Name: Dina Hirshfeld- Becker , PhD Project Role: Independent Evaluator Researcher Identifier...e.g. ORCID ID): Nearest person month worked: 3 Contribution to Project: Dr. Hirshfeld- Becker has been an independent evaluator and has evaluated ...either intranasal oxytocin or placebo. Participants and evaluators will be blind to treatment condition. In year 1 of the study, we set up the study

Uncertainty-based Estimation of the Secure Range for ISO New England Dynamic Interchange Adjustment

DOE Office of Scientific and Technical Information (OSTI.GOV)

Etingov, Pavel V.; Makarov, Yuri V.; Wu, Di

2014-04-14

The paper proposes an approach to estimate the secure range for dynamic interchange adjustment, which assists system operators in scheduling the interchange with neighboring control areas. Uncertainties associated with various sources are incorporated. The proposed method is implemented in the dynamic interchange adjustment (DINA) tool developed by Pacific Northwest National Laboratory (PNNL) for ISO New England. Simulation results are used to validate the effectiveness of the proposed method.

Microbial Interactions with Several Munitions Compounds: 1,3-Dinitrobenzene, 1,3,5-Trinitrobenzene, and 3,5-Dinitroaniline.

DTIC Science & Technology

1982-05-01

3,5-DiNA Biosorption studies were conducted with 3-day Standard Methods broth cultures of Azotobacter beijerinckii (ATCC19366), Bacillus cereus... Biosorption studies with heat killed cells were conducted in the same manner except that the original bacterial mixture was held at 1000 C for 15...minutes. In all cases, studies were conducted with triplicate sets of live or heat killed cells. The biosorption partition coefficient (Kp) was

Consistency of Cluster Analysis for Cognitive Diagnosis: The Reduced Reparameterized Unified Model and the General Diagnostic Model.

PubMed

Chiu, Chia-Yi; Köhn, Hans-Friedrich

2016-09-01

The asymptotic classification theory of cognitive diagnosis (ACTCD) provided the theoretical foundation for using clustering methods that do not rely on a parametric statistical model for assigning examinees to proficiency classes. Like general diagnostic classification models, clustering methods can be useful in situations where the true diagnostic classification model (DCM) underlying the data is unknown and possibly misspecified, or the items of a test conform to a mix of multiple DCMs. Clustering methods can also be an option when fitting advanced and complex DCMs encounters computational difficulties. These can range from the use of excessive CPU times to plain computational infeasibility. However, the propositions of the ACTCD have only been proven for the Deterministic Input Noisy Output "AND" gate (DINA) model and the Deterministic Input Noisy Output "OR" gate (DINO) model. For other DCMs, there does not exist a theoretical justification to use clustering for assigning examinees to proficiency classes. But if clustering is to be used legitimately, then the ACTCD must cover a larger number of DCMs than just the DINA model and the DINO model. Thus, the purpose of this article is to prove the theoretical propositions of the ACTCD for two other important DCMs, the Reduced Reparameterized Unified Model and the General Diagnostic Model.

On the Complexity of Item Response Theory Models.

PubMed

Bonifay, Wes; Cai, Li

2017-01-01

Complexity in item response theory (IRT) has traditionally been quantified by simply counting the number of freely estimated parameters in the model. However, complexity is also contingent upon the functional form of the model. We examined four popular IRT models-exploratory factor analytic, bifactor, DINA, and DINO-with different functional forms but the same number of free parameters. In comparison, a simpler (unidimensional 3PL) model was specified such that it had 1 more parameter than the previous models. All models were then evaluated according to the minimum description length principle. Specifically, each model was fit to 1,000 data sets that were randomly and uniformly sampled from the complete data space and then assessed using global and item-level fit and diagnostic measures. The findings revealed that the factor analytic and bifactor models possess a strong tendency to fit any possible data. The unidimensional 3PL model displayed minimal fitting propensity, despite the fact that it included an additional free parameter. The DINA and DINO models did not demonstrate a proclivity to fit any possible data, but they did fit well to distinct data patterns. Applied researchers and psychometricians should therefore consider functional form-and not goodness-of-fit alone-when selecting an IRT model.

Development of Novel Nonagonist PPAR-Gamma Ligands for Lung Cancer Treatment

DTIC Science & Technology

2016-08-01

Affymetrix gene expression profiling. To get the purest representation of this gene set, we generated fibroblasts from the brown adipose tissue of mice... tissues . It has been shown that p53 plays an important role in metabolism and adipose tissue function, and this may be modulated by PPARγ expression as...presentations. Poster Presentation: Melin J. Khandekar, Alex S. Banks , Dina Laznik- Bogoslavski, James P. White, Jang H. Choi, Kwok-kin Wong, Ted

JPRS Report, Arms Control.

DTIC Science & Technology

1989-04-26

Francisca Chilombo, and 4- year-old Manuel Frederico, 2-year-old Catarina Jamba, and 10-year-old Dina Cassinmbe. These people show symptoms of...Eurico de Melo stated today that Portugal admits the possibility of nuclear weapons being installed on its territory, but added that he hoped the...Eurico de Melo stated that, quote: As NATO founding members we do not shirk our respon- sibilities, because the Atlantic Alliance is a sharing of

A Randomized, Controlled Trial of Intranasal Oxytocin as an Adjunct to Behavioral Therapy for Autism Spectrum Disorder

DTIC Science & Technology

2014-10-01

o Aude Henin, Ph.D. (MGH PI) o Dina Hirshfeld- Becker , Ph.D. (independent evaluator at MGH) o Angela Utschig, Ph.D. (study therapist at MGH) o...intranasal oxytocin or placebo. Participants and evaluators will be blind to treatment condition. In year 1 of the study, we set up the study framework...experimental treatment, and OT before 12 sessions of CBT treatment. Volunteers (patients) and evaluators will be blind to condition assignment

Expedition 32 Docking with ISS

NASA Image and Video Library

2012-07-17

Dina Pandya, Expedition 32 Flight Engineer Sunita Williams’ sister, says hello after her arrival to the International Space Station on Tuesday, July 17, 2012 at the Russian Mission Control Center in Korolev, Russia. The Soyuz docked to the International Space Station with Williams and fellow crew members Soyuz Commander Yuri Malenchenko and JAXA Flight Engineer Akihiko Hoshide two days after they launched from the Baikonur Cosmodrome in Kazakhstan. Photo Credit: (NASA/Carla Cioffi)

The Effect of Bilingual Term List Size on Dictionary-Based Cross-Language Information Retrieval

DTIC Science & Technology

2003-02-01

FEB 2003 2. REPORT TYPE 3. DATES COVERED 00-00-2003 to 00-00-2003 4. TITLE AND SUBTITLE The Effect of Bilingual Term List Size on Dictionary ...298 (Rev. 8-98) Prescribed by ANSI Std Z39-18 The Effect of Bilingual Term List Size on Dictionary -Based Cross-Language Information Retrieval Dina...are extensively used as a resource for dictionary -based Cross-Language Information Retrieval (CLIR), in which the goal is to find documents written

Cardiac Expression of ms1/STARS, a Novel Gene Involved in Cardiac Development and Disease, Is Regulated by GATA4

PubMed Central

Kobayashi, Satoru; Peterson, Richard E.; He, Aibin; Motterle, Anna; Samani, Nilesh J.; Menick, Donald R.; Pu, William T.; Liang, Qiangrong

2012-01-01

Ms1/STARS is a novel muscle-specific actin-binding protein that specifically modulates the myocardin-related transcription factor (MRTF)-serum response factor (SRF) regulatory axis within striated muscle. This ms1/STARS-dependent regulatory axis is of central importance within the cardiac gene regulatory network and has been implicated in cardiac development and postnatal cardiac function/homeostasis. The dysregulation of ms1/STARS is associated with and causative of pathological cardiac phenotypes, including cardiac hypertrophy and cardiomyopathy. In order to gain an understanding of the mechanisms governing ms1/STARS expression in the heart, we have coupled a comparative genomic in silico analysis with reporter, gain-of-function, and loss-of-function approaches. Through this integrated analysis, we have identified three evolutionarily conserved regions (ECRs), α, SINA, and DINA, that act as cis-regulatory modules and confer differential cardiac cell-specific activity. Two of these ECRs, α and DINA, displayed distinct regulatory sensitivity to the core cardiac transcription factor GATA4. Overall, our results demonstrate that within embryonic, neonatal, and adult hearts, GATA4 represses ms1/STARS expression with the pathologically associated depletion of GATA4 (type 1/type 2 diabetic models), resulting in ms1/STARS upregulation. This GATA4-dependent repression of ms1/STARS expression has major implications for MRTF-SRF signaling in the context of cardiac development and disease. PMID:22431517

Compatibility study of trans-1,4,5,8-tetranitro-1,4,5,8-tetraazadecalin (TNAD) with some energetic components and inert materials.

PubMed

Yan, Qi-Long; Xiao-Jiang, Li; La-Ying, Zhang; Ji-Zhen, Li; Hong-Li, Li; Zi-Ru, Liu

2008-12-30

The compatibility of trans-1,4,5,8-tetranitro-1,4,5,8-tetraazadecalin (TNAD) with some energetic components and inert materials of solid propellants was studied by using the pressure DSC method where, cyclotetramethylenetetranitroamine (HMX), cyclotrimethylenetrinitramine (RDX), 1,4-dinitropiperazine (DNP), 1.25/1-NC/NG mixture, lead 3-nitro-1,2,4-triazol-5-onate (NTO-Pb), aluminum powder (Al, particle size=13.6microm) and N-nitrodihydroxyethylaminedinitrate (DINA) were used as energetic components and polyethylene glycol (PEG), polyoxytetramethylene-co-oxyethylene (PET), addition product of hexamethylene diisocyanate and water (N-100), 2-nitrodianiline (2-NDPA), 1,3-dimethyl-1,3-diphenyl urea (C2), carbon black (C.B.), aluminum oxide (Al2O3), cupric 2,4-dihydroxy-benzoate (beta-Cu), cupric adipate (AD-Cu) and lead phthalate (phi-Pb) were used as inert materials. It was concluded that the binary systems of TNAD with NTO-Pb, RDX, PET and Al powder are compatible, and systems of TNAD with DINA and HMX are slightly sensitive, and with 2-NDPA, phi-Pb, beta-Cu, AD-Cu and Al2O3 are sensitive, and with PEG, N-100, C2 and C.B. are incompatible. The impact and friction sensitivity data of the TNAD and TNAD in combination with the other energetic materials under present study was also obtained, and there was no consequential affiliation between sensitivity and compatibility.

Parameter Invariance and Skill Attribute Continuity in the DINA Model

ERIC Educational Resources Information Center

Bolt, Daniel M.; Kim, Jee-Seon

2018-01-01

Cognitive diagnosis models (CDMs) typically assume skill attributes with discrete (often binary) levels of skill mastery, making the existence of skill continuity an anticipated form of model misspecification. In this article, misspecification due to skill continuity is argued to be of particular concern for several CDM applications due to the…

Variable-Length Computerized Adaptive Testing Using the Higher Order DINA Model

ERIC Educational Resources Information Center

Hsu, Chia-Ling; Wang, Wen-Chung

2015-01-01

Cognitive diagnosis models provide profile information about a set of latent binary attributes, whereas item response models yield a summary report on a latent continuous trait. To utilize the advantages of both models, higher order cognitive diagnosis models were developed in which information about both latent binary attributes and latent…

Edge safety factor at the onset of plasma disruption during VDEs in JT-60U

NASA Astrophysics Data System (ADS)

Sugihara, Masayoshi; Lukash, Victor; Khayrutdinov, Rustam; Neyatani, Yuzuru

2004-10-01

Detailed examinations of the value of the edge safety factor (qa) at the onset of thermal quench (TQ) during intentional vertical displacement event (VDE) experiments in JT-60U are carried out using two different reconstruction methods, FBI/FBEQU and DINA. The results from the two methods are very similar and show that the TQ occurs when the qa value is in the range between 1.5 and 2. This result suggests that the predictive simulations for VDEs should be performed within this range of q to examine the subsequent differences in the halo currents, plasma movement and other plasma behaviour during the current quench.

Monitoring the progress of emission inventories

DOE Office of Scientific and Technical Information (OSTI.GOV)

Levy, J.A. Jr.; Solomon, D.; Husk, M.

This issue of EM contains three articles which focus on the latest improvements on the emissions inventory process. The first, 'Building the national emissions inventory: challenges and plans for improvements' by Doug Solomon and Martin Husk (pages 8-11), looks at the US national emissions inventory. The next, 'Greenhouse gas inventories - a historical perspective and assessment of improvements since 1990' by Bill Irving and Dina Kruger (pages 12-19) assesses improvements in national and international greenhouse gas emissions inventories over the last 15 years. The third article, 'The global mercury emissions inventory' by Leonard Levin (pages 20-25) gives an overview ofmore » the challenges associated with conducting a worldwide inventory of mercury emissions.« less

Online Calibration Methods for the DINA Model with Independent Attributes in CD-CAT

ERIC Educational Resources Information Center

Chen, Ping; Xin, Tao; Wang, Chun; Chang, Hua-Hua

2012-01-01

Item replenishing is essential for item bank maintenance in cognitive diagnostic computerized adaptive testing (CD-CAT). In regular CAT, online calibration is commonly used to calibrate the new items continuously. However, until now no reference has publicly become available about online calibration for CD-CAT. Thus, this study investigates the…

Assessment of Differential Item Functioning under Cognitive Diagnosis Models: The DINA Model Example

ERIC Educational Resources Information Center

Li, Xiaomin; Wang, Wen-Chung

2015-01-01

The assessment of differential item functioning (DIF) is routinely conducted to ensure test fairness and validity. Although many DIF assessment methods have been developed in the context of classical test theory and item response theory, they are not applicable for cognitive diagnosis models (CDMs), as the underlying latent attributes of CDMs are…

Recognizing Uncertainty in the Q-Matrix via a Bayesian Extension of the DINA Model

ERIC Educational Resources Information Center

DeCarlo, Lawrence T.

2012-01-01

In the typical application of a cognitive diagnosis model, the Q-matrix, which reflects the theory with respect to the skills indicated by the items, is assumed to be known. However, the Q-matrix is usually determined by expert judgment, and so there can be uncertainty about some of its elements. Here it is shown that this uncertainty can be…

Comparison among cognitive diagnostic models for the TIMSS 2007 fourth grade mathematics assessment.

PubMed

Yamaguchi, Kazuhiro; Okada, Kensuke

2018-01-01

A variety of cognitive diagnostic models (CDMs) have been developed in recent years to help with the diagnostic assessment and evaluation of students. Each model makes different assumptions about the relationship between students' achievement and skills, which makes it important to empirically investigate which CDMs better fit the actual data. In this study, we examined this question by comparatively fitting representative CDMs to the Trends in International Mathematics and Science Study (TIMSS) 2007 assessment data across seven countries. The following two major findings emerged. First, in accordance with former studies, CDMs had a better fit than did the item response theory models. Second, main effects models generally had a better fit than other parsimonious or the saturated models. Related to the second finding, the fit of the traditional parsimonious models such as the DINA and DINO models were not optimal. The empirical educational implications of these findings are discussed.

Comparison among cognitive diagnostic models for the TIMSS 2007 fourth grade mathematics assessment

PubMed Central

Okada, Kensuke

2018-01-01

A variety of cognitive diagnostic models (CDMs) have been developed in recent years to help with the diagnostic assessment and evaluation of students. Each model makes different assumptions about the relationship between students’ achievement and skills, which makes it important to empirically investigate which CDMs better fit the actual data. In this study, we examined this question by comparatively fitting representative CDMs to the Trends in International Mathematics and Science Study (TIMSS) 2007 assessment data across seven countries. The following two major findings emerged. First, in accordance with former studies, CDMs had a better fit than did the item response theory models. Second, main effects models generally had a better fit than other parsimonious or the saturated models. Related to the second finding, the fit of the traditional parsimonious models such as the DINA and DINO models were not optimal. The empirical educational implications of these findings are discussed. PMID:29394257

Chemical decontamination technical resources at Los Alamos National Laboratory (2008)

DOE Office of Scientific and Technical Information (OSTI.GOV)

Moore, Murray E

This document supplies information resources for a person seeking to create planning or pre-planning documents for chemical decontamination operations. A building decontamination plan can be separated into four different sections: Pre-planning, Characterization, Decontamination (Initial response and also complete cleanup), and Clearance. Of the identified Los Alamos resources, they can be matched with these four sections: Pre-planning -- Dave Seidel, EO-EPP, Emergency Planning and Preparedness; David DeCroix and Bruce Letellier, D-3, Computational fluids modeling of structures; Murray E. Moore, RP-2, Aerosol sampling and ventilation engineering. Characterization (this can include development projects) -- Beth Perry, IAT-3, Nuclear Counterterrorism Response (SNIPER database); Fernandomore » Garzon, MPA-11, Sensors and Electrochemical Devices (development); George Havrilla, C-CDE, Chemical Diagnostics and Engineering; Kristen McCabe, B-7, Biosecurity and Public Health. Decontamination -- Adam Stively, EO-ER, Emergency Response; Dina Matz, IHS-IP, Industrial hygiene; Don Hickmott, EES-6, Chemical cleanup. Clearance (validation) -- Larry Ticknor, CCS-6, Statistical Sciences.« less

Numerical investigation of disruption characteristics for the snowflake divertor configuration in HL-2M

NASA Astrophysics Data System (ADS)

Xue, L.; Duan, X. R.; Zheng, G. Y.; Liu, Y. Q.; Pan, Y. D.; Yan, S. L.; Dokuka, V. N.; Lukash, V. E.; Khayrutdinov, R. R.

2016-05-01

Cold and hot vertical displacement events (VDEs) are frequently related to the disruption of vertically-elongated tokamaks. The weak poloidal magnetic field around the null-points of a snowflake divertor configuration may influence the vertical displacement process. In this paper, the major disruption with a cold VDE and the vertical disruption in the HL-2M tokamak are investigated by the DINA code. In order to better illustrate the effect from the weak poloidal field, a double-null snowflake configuration is compared with the standard divertor (SD) configuration under the same plasma parameters. Computational results show that the weak poloidal magnetic field can be partly beneficial for mitigating the vertical instability of the plasma under small perturbations. For major disruption, the peak poloidal halo current fraction is almost the same between the snowflake and the SD configurations. However, this fraction becomes much larger for the snowflake in the event of a hot VDE. Furthermore, during the disruption for a snowflake configuration, the distribution of electromagnetic force on a vacuum vessel gets more non-uniform during the current quench.

Differential Item Functioning Assessment in Cognitive Diagnostic Modeling: Application of the Wald Test to Investigate DIF in the DINA Model

ERIC Educational Resources Information Center

Hou, Likun; de la Torre, Jimmy; Nandakumar, Ratna

2014-01-01

Analyzing examinees' responses using cognitive diagnostic models (CDMs) has the advantage of providing diagnostic information. To ensure the validity of the results from these models, differential item functioning (DIF) in CDMs needs to be investigated. In this article, the Wald test is proposed to examine DIF in the context of CDMs. This study…

Insights on Na(+) binding and conformational dynamics in multidrug and toxic compound extrusion transporter NorM.

PubMed

Song, Jianing; Ji, Changge; Zhang, John Z H

2014-02-01

MATE (multidrug and toxic compound extrusion) transporter proteins mediate metabolite transport in plants and multidrug resistance in bacteria and mammals. MATE transporter NorM from Vibrio cholerae is an antiporter that is driven by Na+ gradient to extrude the substrates. To understand the molecular mechanism of Na+-substrate exchange, molecular dynamics simulation was performed to study conformational changes of both wild-type and mutant NorM with and without cation bindings. Our results show that NorM is able to bind two Na(+) ions simultaneously, one to each of the carboxylic groups of E255 and D371 in the binding pocket. Furthermore, this di-Na(+) binding state is likely more efficient for conformational changes of NorM_VC toward the inward-facing conformation than single-Na(+) binding state. The observation of two Na(+) binding sites of NorM_VC is consistent with the previous study that two sites for ion binding (denoted as Na1/Na2 sites) are found in the transporter LeuT and BetP, another two secondary transporters. Taken together, our findings shed light on the structure rearrangements of NorM on Na(+) binding and enrich our knowledge of the transport mechanism of secondary transporters. Copyright © 2013 Wiley Periodicals, Inc.

A Fuzzy analytical hierarchy process approach in irrigation networks maintenance

NASA Astrophysics Data System (ADS)

Riza Permana, Angga; Rintis Hadiani, Rr.; Syafi'i

2017-11-01

Ponorogo Regency has 440 Irrigation Area with a total area of 17,950 Ha. Due to the limited budget and lack of maintenance cause decreased function on the irrigation. The aim of this study is to make an appropriate system to determine the indices weighted of the rank prioritization criteria for irrigation network maintenance using a fuzzy-based methodology. The criteria that are used such as the physical condition of irrigation networks, area of service, estimated maintenance cost, and efficiency of irrigation water distribution. 26 experts in the field of water resources in the Dinas Pekerjaan Umum were asked to fill out the questionnaire, and the result will be used as a benchmark to determine the rank of irrigation network maintenance priority. The results demonstrate that the physical condition of irrigation networks criterion (W1) = 0,279 has the greatest impact on the assessment process. The area of service (W2) = 0,270, efficiency of irrigation water distribution (W4) = 0,249, and estimated maintenance cost (W3) = 0,202 criteria rank next in effectiveness, respectively. The proposed methodology deals with uncertainty and vague data using triangular fuzzy numbers, and, moreover, it provides a comprehensive decision-making technique to assess maintenance priority on irrigation network.

KSC-07pd2209

NASA Image and Video Library

2007-08-03

KENNEDY SPACE CENTER, FLA. - In Orbiter Processing Facility bay 3, STS-120 crew members practice handling tools they will use during the mission. Around the table, at center, dressed in blue flight suits are Mission Specialists Scott E. Parazynski, Douglas H. Wheelock, Paolo A. Nespoli and Expedition 16 Flight Engineer Daniel M. Tani. Between Wheelock and Nespoli is Allison Bolinger, an EVA technician with NASA. In the foreground is Dina Contella, a thermal protection system specialist with NASA. Nespoli is a European Space Agency astronaut from Italy. The STS-120 crew is at Kennedy for a crew equipment interface test, or CEIT, which includes harness training, inspection of the thermal protection system and camera operation for planned extravehicular activities, or EVAs. The STS-120 mission will deliver the Harmony module, christened after a school contest, which will provide attachment points for European and Japanese laboratory modules on the International Space Station. Known in technical circles as Node 2, it is similar to the six-sided Unity module that links the U.S. and Russian sections of the station. Built in Italy for the United States, Harmony will be the first new U.S. pressurized component to be added. The STS-120 mission is targeted to launch on Oct. 20. Photo credit: NASA/George Shelton

Technical-Information Products for a National Volcano Early Warning System

USGS Publications Warehouse

Guffanti, Marianne; Brantley, Steven R.; Cervelli, Peter F.; Nye, Christopher J.; Serafino, George N.; Siebert, Lee; Venezky, Dina Y.; Wald, Lisa

2007-01-01

Introduction Technical outreach - distinct from general-interest and K-12 educational outreach - for volcanic hazards is aimed at providing usable scientific information about potential or ongoing volcanic activity to public officials, businesses, and individuals in support of their response, preparedness, and mitigation efforts. Within the context of a National Volcano Early Warning System (NVEWS) (Ewert et al., 2005), technical outreach is a critical process, transferring the benefits of enhanced monitoring and hazards research to key constituents who have to initiate actions or make policy decisions to lessen the hazardous impact of volcanic activity. This report discusses recommendations of the Technical-Information Products Working Group convened in 2006 as part of the NVEWS planning process. The basic charge to the Working Group was to identify a web-based, volcanological 'product line' for NVEWS to meet the specific hazard-information needs of technical users. Members of the Working Group were: *Marianne Guffanti (Chair), USGS, Reston VA *Steve Brantley, USGS, Hawaiian Volcano Observatory HI *Peter Cervelli, USGS, Alaska Volcano Observatory, Anchorage AK *Chris Nye, Division of Geological and Geophysical Surveys and Alaska Volcano Observatory, Fairbanks AK *George Serafino, National Oceanic and Atmospheric Administration, Camp Springs MD *Lee Siebert, Smithsonian Institution, Washington DC *Dina Venezky, USGS, Volcano Hazards Team, Menlo Park CA *Lisa Wald, USGS, Earthquake Hazards Program, Golden CO

Effects of the second X-point on hot VDE in HL-2M

NASA Astrophysics Data System (ADS)

Xue, L.; Duan, X. R.; Zheng, G. Y.; Liu, Y. Q.; Dokuka, V. N.; Lukash, V. E.; Khayrutdinov, R. R.

2017-05-01

Study of the hot-plasma vertical displacement event (VDE) in advanced divertor configurations is of significant importance for ITER and for future fusion reactors. The newly designed, medium-sized copper-conductor machine HL-2M has the capability of generating the second X-point for various advanced divertor configurations. In this paper, effects of the second X-point on the hot VDE in HL-2M are numerically investigated by utilizing the non-linear time-dependent DINA code. The simulation results show that the existence of the second X-point at certain special locations appears to have a better stability in the vertical direction, compared to the standard configuration with the same main plasma parameters. Meanwhile, the peak halo current during the current quench tends to increase as the second X-point changes in the horizontal direction. The same quantity decreases as the second X-point changes in the vertical direction away from the dominant X-point. From the view point of minimizing the halo current, the tripod is better than the standard configuration, followed by the snowflake-plus and the exact snowflake (SF) configuration. The SF-minus is the worst scenario. On the other hand, the tripod configuration, as well as the SF minus configurations, results in relatively higher peak electromagnetic force acting on the vacuum vessel, when compared to other aforementioned configurations.

Survival and in-vessel redistribution of beryllium droplets after ITER disruptions

NASA Astrophysics Data System (ADS)

Vignitchouk, L.; Ratynskaia, S.; Tolias, P.; Pitts, R. A.; De Temmerman, G.; Lehnen, M.; Kiramov, D.

2018-07-01

The motion and temperature evolution of beryllium droplets produced by first wall surface melting after ITER major disruptions and vertical displacement events mitigated during the current quench are simulated by the MIGRAINe dust dynamics code. These simulations employ an updated physical model which addresses droplet-plasma interaction in ITER-relevant regimes characterized by magnetized electron collection and thin-sheath ion collection, as well as electron emission processes induced by electron and high-Z ion impacts. The disruption scenarios have been implemented from DINA simulations of the time-evolving plasma parameters, while the droplet injection points are set to the first-wall locations expected to receive the highest thermal quench heat flux according to field line tracing studies. The droplet size, speed and ejection angle are varied within the range of currently available experimental and theoretical constraints, and the final quantities of interest are obtained by weighting single-trajectory output with different size and speed distributions. Detailed estimates of droplet solidification into dust grains and their subsequent deposition in the vessel are obtained. For representative distributions of the droplet injection parameters, the results indicate that at most a few percents of the beryllium mass initially injected is converted into solid dust, while the remaining mass either vaporizes or forms liquid splashes on the wall. Simulated in-vessel spatial distributions are also provided for the surviving dust, with the aim of providing guidance for planned dust diagnostic, retrieval and clean-up systems on ITER.

BLOBS IN SPACE: THE LEGACY OF A NOVA

NASA Technical Reports Server (NTRS)

2002-01-01

TThe prolific number of eruptions by the recurrent nova T Pyxidis has attracted the attention of many telescopes. The image on the left, taken by a ground-based telescope, shows shells of gas around the star that were blown off during several eruptions. Closer inspection by the Hubble Space Telescope (right-hand image), however, reveals that the shells are not smooth at all. In fact, this high-resolution image shows that the shells are actually more than 2,000 gaseous blobs packed into an area that is 1 light-year across. Resembling shrapnel from a shotgun blast, the blobs may have been produced by the nova explosion, the subsequent expansion of gaseous debris, or collisions between fast-moving and slow- moving gas from several eruptions. False color has been applied to this image to enhance details in the blobs. The ground-based image was taken Jan. 19, 1995 by the European Southern Observatory's New Technology Telescope in La Silla, Chile. The Hubble telescope picture is a compilation of data taken on Feb. 26, 1994, and June 16, Oct. 7, and Nov. 10, 1995, by the Wide Field and Planetary Camera 2. T Pyxidis is 6,000 light-years away in the dim southern constellation Pyxis, the Mariner's Compass. Credits: Mike Shara, Bob Williams, and David Zurek (Space Telescope Science Institute); Roberto Gilmozzi (European Southern Observatory); Dina Prialnik (Tel Aviv University); and NASA.

The Effectiveness of Building Permit Regulation for Green Open Space at Housing Estates: Case Study of Kendal Regency, Central Java, Indonesia

NASA Astrophysics Data System (ADS)

Yulianti, Wiwik; Hadi, Sudharto P.

2018-02-01

Increasing demand for settlements steamed by population growth declines the quality of the environment specifically at urban area. The existing spatial planning could not able to prevent the change of land use for settlement and other infrastructures. The Act no. 26 of 2007 on spatial planning stipulates that green open space must reach 30% of the total area, consisting of 20% public open space and 10% private open space. The existing condition of urban area at Kendal Regency reach 245,6 million m2 with 88.145,5 m2 green open space or 0,036% out of total area. An effort to increase green open space in urban areas taken by the Government of Kendal Regency is by promulgating a local regulation stipulating that each housing developer request a building permit is obliged to provide a green open space at least 10 percent of the total housing area. This paper reviews the effectiveness of building permit regulation, the problems encountered and the concept proposed to make the local regulation work. The area of sample taken is three urban districts out of five urban districts, the resource persons chosen are those from relevant offices (Dinas) involved at the implementation of the local regulation. The data collection techniques employed are the Analytical Hierarchy Process (AHP), Geographic Information System (GIS) technology, social observation and informal interview. The data gathered will be analyzed quantitatively and qualitatively.

A comparison of two global datasets of extreme sea levels and resulting flood exposure

NASA Astrophysics Data System (ADS)

Muis, Sanne; Verlaan, Martin; Nicholls, Robert J.; Brown, Sally; Hinkel, Jochen; Lincke, Daniel; Vafeidis, Athanasios T.; Scussolini, Paolo; Winsemius, Hessel C.; Ward, Philip J.

2017-04-01

Estimating the current risk of coastal flooding requires adequate information on extreme sea levels. For over a decade, the only global data available was the DINAS-COAST Extreme Sea Levels (DCESL) dataset, which applies a static approximation to estimate extreme sea levels. Recently, a dynamically derived dataset was developed: the Global Tide and Surge Reanalysis (GTSR) dataset. Here, we compare the two datasets. The differences between DCESL and GTSR are generally larger than the confidence intervals of GTSR. Compared to observed extremes, DCESL generally overestimates extremes with a mean bias of 0.6 m. With a mean bias of -0.2 m GTSR generally underestimates extremes, particularly in the tropics. The Dynamic Interactive Vulnerability Assessment model is applied to calculate the present-day flood exposure in terms of the land area and the population below the 1 in 100-year sea levels. Global exposed population is 28% lower when based on GTSR instead of DCESL. Considering the limited data available at the time, DCESL provides a good estimate of the spatial variation in extremes around the world. However, GTSR allows for an improved assessment of the impacts of coastal floods, including confidence bounds. We further improve the assessment of coastal impacts by correcting for the conflicting vertical datum of sea-level extremes and land elevation, which has not been accounted for in previous global assessments. Converting the extreme sea levels to the same vertical reference used for the elevation data is shown to be a critical step resulting in 39-59% higher estimate of population exposure.

Increasing Physical Activity Amongst Overweight and Obese Cancer Survivors Using an Alexa-Based Intelligent Agent for Patient Coaching: Protocol for the Physical Activity by Technology Help (PATH) Trial.

PubMed

Hassoon, Ahmed; Schrack, Jennifer; Naiman, Daniel; Lansey, Dina; Baig, Yasmin; Stearns, Vered; Celentano, David; Martin, Seth; Appel, Lawrence

2018-02-12

Physical activity has established health benefits, but motivation and adherence remain challenging. We designed and launched a three-arm randomized trial to test artificial intelligence technology solutions to increase daily physical activity in cancer survivors. A single-center, three-arm randomized clinical trial with an allocation ration of 1:1:1: (A) control, in which participants are provided written materials about the benefits of physical activity; (B) text intervention, where participants receive daily motivation from a fully automated, data-driven algorithmic text message via mobile phone (Coachtext); and (C) Voice Assist intervention, where participants are provided with an in-home on demand autonomous Intelligent Agent using data driven Interactive Digital Voice Assist on the Amazon Alexa/Echo (MyCoach). The study runs for 5 weeks: a one-week run-in to establish baseline, followed by 4 weeks of intervention. Data for study outcomes is collected automatically through a wearable sensor, and data are transferred in real-time to the study server. The recruitment goal is 42 participants, 14 in each arm. Electronic health records are used to prescreen candidates, with 39 participants recruited to date. This study aims to investigate the effects of different types of intelligent technology solutions on promoting physical activity in cancer survivors. This innovative approach can easily be expanded and customized to other interventions. Early lessons from our initial participants are helping us develop additional advanced solutions to improve health outcomes. Retrospectively registered on July 10, 2017 at ClinicalTrials.gov: NCT03212079; https://clinicaltrials.gov/ct2/show/NCT03212079 (Archived by WebCite at http://www.webcitation.org/6wgvqjTji). ©Ahmed Hassoon, Jennifer Schrack, Daniel Naiman, Dina Lansey, Yasmin Baig, Vered Stearns, David Celentano, Seth Martin, Lawrence Appel. Originally published in JMIR Research Protocols (http

Investigation of the primary plasticisers present in polyvinyl chloride (PVC) products currently authorised as food contact materials.

PubMed

Carlos, Katherine S; de Jager, Lowri S; Begley, Timothy H

2018-03-15

PVC is a common food contact material that is usually plasticised to increase its flexibility. Phthalates are one class of chemical compounds that are often used as plasticisers in PVC in a wide range of industries. They may be used in packaging materials for foods and can also be found in components of certain food processing equipment such as conveyor belts and tubing. Transfer of plasticisers from packaging to foods can occur. In recent years, there has been increased interest in understanding the health effects of phthalates, as well as the possible human exposure levels. However, there is limited information available about the routes of exposure to phthalates. In July 2014, the Chronic Hazard Advisory Panel (CHAP) produced a report for the U.S. Consumer Product Safety Commission detailing the potential health hazards of phthalates and phthalate alternatives. This report listed diet as one factor contributing greater than or equal to 10% of total phthalate exposure. As a result of this report, the U.S. Food and Drug Administration (FDA) is interested in determining the types of the primary plasticiser present in food packaging and processing materials as well as their concentrations. An investigation was conducted of 56 different samples of PVC food packaging and food processing materials available in the US market using a solvent extraction and GC-MS analysis. Nine different plasticisers including three phthalates, di(2-ethylhexyl) phthalate, diisononyl phthalate and diisodecyl phthalate, were identified in the products tested. The plasticiser concentrations ranged from 1 to 53% depending on the types of food contact materials and the type of plasticiser. Overall, it appears that manufacturers are switching away from phthalates as their primary plasticiser to alternate compounds such as ESBO, ATBC, DEHT, DINCH, DEHA and DINA.

Integration of borehole and seismic data to unravel complex stratigraphy: Case studies from the Mannville Group, Western Canada

NASA Astrophysics Data System (ADS)

Sarzalejo Silva, Sabrina Ester

Understanding the stratigraphic architecture of geologically complex reservoirs, such as the heavy oil deposits of Western Canada, is essential to achieve an efficient hydrocarbon recovery. Borehole and 3-D seismic data were integrated to define the stratigraphic architecture and generate 3-dimensional geological models of the Mannville Group in Saskatchewan. The Mannville is a stratigraphically complex unit formed of fluvial to marine deposits. Two areas in west-central and southern Saskatchewan were examined in this study. In west-central Saskatchewan, the area corresponds to a stratigraphically controlled heavy oil reservoir with production from the undifferentiated Dina-Cummings Members of the Lower Cretaceous Mannville Group. The southern area, although non-prospective for hydrocarbons, shares many similarities with time-equivalent strata in areas of heavy oil production. Seismic sequence stratigraphic principles together with log signatures permitted the subdivision of the Mannville into different packages. An initial geological model was generated integrating seismic and well-log data Multiattribute analysis and neural networks were used to generate a pseudo-lithology or gamma-ray volume. The incorporation of borehole core data to the model and the subsequent integration with the lithological prediction were crucial to capture the distribution of reservoir and non-reservoir deposits in the study area. The ability to visualize the 3-D seismic data in a variety of ways, including arbitrary lines and stratal or horizon slicing techniques helped the definition of stratigraphic features such as channels and scroll bars that affect fluid flow in hydrocarbon producing areas. Small-scale heterogeneities in the reservoir were not resolved due to the resolution of the seismic data. Although not undertaken in this study, the resulting stratigraphic framework could be used to help construct a static reservoir model. Because of the small size of the 3-D seismic surveys

Pm55, a developmental-stage and tissue-specific powdery mildew resistance gene introgressed from Dasypyrum villosum into common wheat.

PubMed

Zhang, Ruiqi; Sun, Bingxiao; Chen, Juan; Cao, Aizhong; Xing, Liping; Feng, Yigao; Lan, Caixia; Chen, Peidu

2016-10-01

Powdery mildew resistance gene Pm55 was physically mapped to chromosome arm 5VS FL 0.60-0.80 of Dasypyrum villosum . Pm55 is present in T5VS·5AL and T5VS·5DL translocations, which should be valuable resources for wheat improvement. Powdery mildew caused by Blumeria graminis f. sp. tritici is a major wheat disease worldwide. Exploiting novel genes effective against powdery mildew from wild relatives of wheat is a promising strategy for controlling this disease. To identify novel resistance genes for powdery mildew from Dasypyrum villosum, a wild wheat relative, we evaluated a set of Chinese Spring-D. villosum disomic addition and whole-arm translocation lines for reactions to powdery mildew. Based on the evaluation data, we concluded that the D. villosum chromosome 5V controls post-seedling resistance to powdery mildew. Subsequently, three introgression lines were developed and confirmed by molecular and cytogenetic analysis following ionizing radiation of the pollen of a Chinese Spring-D. villosum 5V disomic addition line. A homozygous T5VS·5AL translocation line (NAU421) with good plant vigor and full fertility was further characterized using sequential genomic in situ hybridization, C-banding, and EST-STS marker analysis. A dominant gene permanently named Pm55 was located in chromosome bin 5VS 0.60-0.80 based on the responses to powdery mildew of all wheat-D. villosum 5V introgression lines evaluated at both seeding and adult stages. This study demonstrated that Pm55 conferred growth-stage and tissue-specific dependent resistance; therefore, it provides a novel resistance type for powdery mildew. The T5VS·5AL translocation line with additional softness loci Dina/Dinb of D. villosum provides a possibility of extending the range of grain textures to a super-soft category. Accordingly, this stock is a new source of resistance to powdery mildew and may be useful in both resistance mechanism studies and soft wheat improvement.

The evolution of the centrifugal visual system of vertebrates. A cladistic analysis and new hypotheses.

PubMed

Repérant, J; Médina, M; Ward, R; Miceli, D; Kenigfest, N B; Rio, J P; Vesselkin, N P

2007-01-01

In a recent review of the available data concerning the centrifugal visual system (CVS) of vertebrates [Repérant, J., Ward, R., Miceli, D., Rio, J.P., Médina, M., Kenigfest, N.B., Vesselkin, N.P., 2006. The centrifugal visual system of vertebrates: a comparative analysis of its functional anatomical organization, Brain Res. Rev. 52, 1-57], we have shown that this feature of the visual system is not a particularity of birds, but is a permanent component of the vertebrate central nervous system which nevertheless shows considerable morphological and functional variation from one taxonomic group to another. Given these findings, the primary objective of the present article is an attempt to specify the evolutionary significance of this phylogenetic diversity. We begin by drawing up an inventory of this variation under several headings: the intracerebral location of the retinopetal neurons; the mode of intra-retinal arborizations of the centrifugal fibres and the nature of their targets; their neurochemical properties; and the afferent supplies of these neurons. We subsequently discuss these variations, particularly that of the intracerebral location of the retinopetal neurons during development and in adult forms, using the neuromeric terminology and in the framework of cladistic analysis, and seek to interpret them in a phylogenetic context. From this analysis, it becomes evident that the CVS is not a homogeneous entity formed by neurons with a common embryological origin, but rather a collection of at least eight distinct subsystems arising in very different regions of the neuraxis. These are the olfacto-retinal, dorsal thalamo-retinal, ventral thalamo-retinal, pretecto-retinal, tecto-retinal, tegmento-mesencephalo-retinal, dorsal isthmo-retinal and ventral isthmo-retinal systems. The olfacto-retinal system, which is probably absent in Agnatha, appears to be a pleisiomorphic characteristic of all Gnathostomata, while on the other hand the tegmento

A Patient-Held Smartcard With a Unique Identifier and an mHealth Platform to Improve the Availability of Prenatal Test Results in Rural Nigeria: Demonstration Study.

PubMed

Gbadamosi, Semiu Olatunde; Eze, Chuka; Olawepo, John Olajide; Iwelunmor, Juliet; Sarpong, Daniel F; Ogidi, Amaka Grace; Patel, Dina; Oko, John Okpanachi; Onoka, Chima; Ezeanolue, Echezona Edozie

2018-01-15

�Semiu Olatunde Gbadamosi, Chuka Eze, John Olajide Olawepo, Juliet Iwelunmor, Daniel F Sarpong, Amaka Grace Ogidi, Dina Patel, John Okpanachi Oko, Chima Onoka, Echezona Edozie Ezeanolue. Originally published in the Journal of Medical Internet Research (http://www.jmir.org), 15.01.2018.

Emerging Technologies for Integrating Multi-Scale Observations of the Hydrologic Cycle

NASA Astrophysics Data System (ADS)

Logan, W. S.; Potter, K. W.; Wood, E. F.

2007-12-01

western U.S. The committee was chaired by Kenneth W. Potter and vice-chaired by Eric F. Wood. Additional committee members were Roger C. Bales, Lawrence E. Band, Elfatih A.B. Eltahir, Anthony W. England, James S. Famiglietti, Konstantine P. Georgakakos, Dina L. Lopez, Daniel P. Loucks, Patricia A. Maurice, Leal A. Mertes, William K. Michener, and Bridget R. Scanlon. The study and its parent entity, the Committee on Hydrologic Science, were funded by NASA, NSF, USACE, NOAA, NRC, and EPA.

A pilot study of the Incredible Years Teacher Training programme and a curriculum unit on social and emotional skills in community pre-schools in Jamaica.

PubMed

Baker-Henningham, H; Walker, S; Powell, C; Gardner, J Meeks

2009-09-01

School-based interventions involving teacher and/or child training have been shown to benefit teacher practices and to prevent conduct problems and improve children's social and emotional competence in developed countries; however, we are aware of no reports from a developing country. We conducted a pilot study of the Incredible Years Teacher Training programme and a curriculum unit on social and emotional skills based on concepts and activities drawn from the Incredible Years Dina Dinosaur Classroom Curriculum to determine if this approach is appropriate for use with Jamaican pre-school teachers and children. Five pre-schools in Kingston, Jamaica were randomly assigned to an intervention (3 pre-schools with 15 classrooms) or control (2 pre-schools with 12 classrooms) condition. Intervention involved seven whole-day teacher workshops using the Incredible Years Teacher Training programme supplemented by 14 child lessons in each class. The project was evaluated through structured observations of four categories of teacher behaviour and four observer ratings: two rating scales of child behaviour and two rating scales of classroom atmosphere. Significant intervention benefits were found to teachers' behaviour with increased positive behaviour [b = 7.9; 95% confidence interval (CI): 3.5, 12.3], reduced negative behaviour (b =-3.5; 95% CI: -6.6, -0.2) and increases in the extent to which teachers promoted children's social and emotional skills (b = 46.4; 95% CI: 11.0, 81.7). The number of teacher commands was not significantly reduced (b =-2.71; 95% CI: -6.01, 0.59). Significant intervention benefits were found to ratings of child behaviour with an increase in children's appropriate behaviour (b = 5.7, 95% CI: 1.0, 10.8) and in children's interest and enthusiasm (b = 7.2, 95% CI: 0.9, 13.5). Intervention also benefited classroom atmosphere with increases in opportunities provided for children to share and help each other (b = 1.3, 95% CI: 0.5, 2.1) and in teacher warmth

An mHealth Framework to Improve Birth Outcomes in Benue State, Nigeria: A Study Protocol.

PubMed

Ezeanolue, Echezona Edozie; Gbadamosi, Semiu Olatunde; Olawepo, John Olajide; Iwelunmor, Juliet; Sarpong, Daniel; Eze, Chuka; Ogidi, Amaka; Patel, Dina; Onoka, Chima

2017-05-26

-based interventions in real time to improve health outcomes. ClinicalTrials.gov NCT03027258; https://clinicaltrials.gov/ct2/show/NCT03027258 (Archived by WebCite at http://www.webcitation.org/6owR2D0kE). ©Echezona Edozie Ezeanolue, Semiu Olatunde Gbadamosi, John Olajide Olawepo, Juliet Iwelunmor, Daniel Sarpong, Chuka Eze, Amaka Ogidi, Dina Patel, Chima Onoka. Originally published in JMIR Research Protocols (http://www.researchprotocols.org), 26.05.2017.

Nucleotide sequence of wild-type hepatitis A virus GBM in comparison with two cell culture-adapted variants.

PubMed Central

Graff, J; Normann, A; Feinstone, S M; Flehmig, B

1994-01-01

In order to study cell tropism and attenuation of hepatitis A virus (HAV), the genome of HAV wild-type GBM and two cell culture-adapted variants, GBM/FRhK and GBM/HFS, were cloned and sequenced after amplification by reverse transcriptase-PCR. During virus cultivation, the HAV variant GBM/FRhK had a strict host range for FRhK-4 cells, in contrast to GBM/HFS, which can be grown in HFS and FRhK-4 cells. The HAV variant GBM/HFS was shown to be attenuated when inoculated into chimpanzees (B. Flehmig, R. F. Mauler, G. Noll, E. Weinmann, and J. P. Gregerson, p. 87-90, in A. Zuckerman, ed., Viral Hepatitis and Liver Disease, 1988). On the basis of this biological background, the comparison of the nucleotide sequences of these three HAV GBM variants should elucidate differences which may be of importance for cell tropism and attenuation. The comparison of the genome between the GBM wild type and HAV wild types HM175 (J. I. Cohen, J. R. Ticehurst, R. H. Purcell, A. Buckler-White, and B. M. Baroudy, J. Virol. 61:50-59, 1987) and HAV-LA (R. Najarian, O. Caput, W. Gee, S. J. Potter, A. Renard, J. Merryweather, G. Van Nest, and D. Dina, Proc. Natl. Acad. Sci. USA 82:2627-2631, 1985) showed a 92 to 96.3% identity, whereas the identity was 99.3 to 99.6% between the GBM variants. Nucleotide differences between the wild-type and the cell culture-adapted variants, which were identical in both cell culture-adapted GBM variants, were localized in the 5' noncoding region; in 2B, 3B, and 3D; and in the 3' noncoding region. Our result concerning the 2B/2C region confirms a mutation at position 3889 (C-->T, alanine to valine), which had been shown to be of importance for cell culture adaptation (S. U. Emerson, C. McRill, B. Rosenblum, S. M. Feinstone, and R. H. Purcell, J. Virol. 65:4882-4886, 1991; S. U. Emerson, Y. K. Huang, C. McRill, M. Lewis, and R. H. Purcell, J. Virol. 66:650-654, 1992), whereas other mutations differ from published HAV sequence data and may be cell specific

Coastal vulnerability: climate change and natural hazards perspectives

NASA Astrophysics Data System (ADS)

Romieu, E.; Vinchon, C.

2009-04-01

Introduction Studying coastal zones as a territorial concept (Integrated coastal zone management) is an essential issue for managers, as they have to consider many different topics (natural hazards, resources management, tourism, climate change…). The recent approach in terms of "coastal vulnerability" studies (since the 90's) is the main tool used nowadays to help them in evaluating impacts of natural hazards on coastal zones, specially considering climate change. This present communication aims to highlight the difficulties in integrating this concept in risk analysis as it is usually practiced in natural hazards sciences. 1) Coastal vulnerability as a recent issue The concept of coastal vulnerability mainly appears in the International panel on climate change works of 1992 (IPCC. 2001), where it is presented as essential for climate change adaptation. The concept has been defined by a common methodology which proposes the assessment of seven indicators, in regards to a sea level rise of 1m in 2100: people affected, people at risk, capital value at loss, land at loss, wetland at loss, potential adaptation costs, people at risk assuming this adaptation. Many national assessments have been implemented (Nicholls, et al. 1995) and a global assessment was proposed for three indicators (Nicholls, et al. 1999). The DINAS-Coast project reuses this methodology to produce the DIVA-tool for coastal managers (Vafeidis, et al. 2004). Besides, many other methodologies for national or regional coastal vulnerability assessments have been developed (review by (UNFCCC. 2008). The use of aggregated vulnerability indicators (including geomorphology, hydrodynamics, climate change…) is widespread: the USGS coastal vulnerability index is used worldwide and was completed by a social vulnerability index (Boruff, et al. 2005). Those index-based methods propose a vulnerability mapping which visualise indicators of erosion, submersion and/or socio economic sensibility in coastal zones

Pulmonary Rehabilitation With Balance Training for Fall Reduction in Chronic Obstructive Pulmonary Disease: Protocol for a Randomized Controlled Trial.

PubMed

Beauchamp, Marla K; Brooks, Dina; Ellerton, Cindy; Lee, Annemarie; Alison, Jennifer; Camp, Pat G; Dechman, Gail; Haines, Kimberley; Harrison, Samantha L; Holland, Anne E; Marques, Alda; Moineddin, Rahim; Skinner, Elizabeth H; Spencer, Lissa; Stickland, Michael K; Xie, Feng; Goldstein, Roger S

2017-11-20

be returned to the research centers in prepaid envelopes each month. Secondary measures collected by a blinded assessor at baseline (pre-PR), post-PR, and 12-month follow-up will include clinical measures of balance, balance confidence, functional lower body strength, and health status. The cost-effectiveness of the intervention group compared with the control group will be evaluated using the incremental cost per number of falls averted and the incremental cost per quality-adjusted life years gained. Recruitment for the study began in January 2017 and is anticipated to be complete by December 2019. Results are expected to be available in 2020. Findings from this study will improve our understanding of the effectiveness and resource uses of tailored balance training for reducing falls in individuals with COPD. If effective, the intervention represents an opportunity to inform international guidelines and health policy for PR in individuals with COPD who are at risk of falling. ClinicalTrials.gov NCT02995681; https://clinicaltrials.gov/ct2/show/NCT02995681 (Archived by WebCite at http://www.webcitation.org/6ukhxgAsg). ©Marla K Beauchamp, Dina Brooks, Cindy Ellerton, Annemarie Lee, Jennifer Alison, Pat G Camp, Gail Dechman, Kimberley Haines, Samantha L Harrison, Anne E Holland, Alda Marques, Rahim Moineddin, Elizabeth H Skinner, Lissa Spencer, Michael K Stickland, Feng Xie, Roger S Goldstein. Originally published in JMIR Research Protocols (http://www.researchprotocols.org), 20.11.2017.

It's time for a crisper image of the Face of the Earth: Landsat and climate time series for massive land cover & climate change mapping at detailed resolution.

NASA Astrophysics Data System (ADS)

Pons, Xavier; Miquel, Ninyerola; Oscar, González-Guerrero; Cristina, Cea; Pere, Serra; Alaitz, Zabala; Lluís, Pesquer; Ivette, Serral; Joan, Masó; Cristina, Domingo; Maria, Serra Josep; Jordi, Cristóbal; Chris, Hain; Martha, Anderson; Juanjo, Vidal

2014-05-01

Combining climate dynamics and land cover at a relative coarse resolution allows a very interesting approach to global studies, because in many cases these studies are based on a quite high temporal resolution, but they may be limited in large areas like the Mediterranean. However, the current availability of long time series of Landsat imagery and spatially detailed surface climate models allow thinking on global databases improving the results of mapping in areas with a complex history of landscape dynamics, characterized by fragmentation, or areas where relief creates intricate climate patterns that can be hardly monitored or modeled at coarse spatial resolutions. DinaCliVe (supported by the Spanish Government and ERDF, and by the Catalan Government, under grants CGL2012-33927 and SGR2009-1511) is the name of the project that aims analyzing land cover and land use dynamics as well as vegetation stress, with a particular emphasis on droughts, and the role that climate variation may have had in such phenomena. To meet this objective is proposed to design a massive database from long time series of Landsat land cover products (grouped in quinquennia) and monthly climate records (in situ climate data) for the Iberian Peninsula (582,000 km2). The whole area encompasses 47 Landsat WRS2 scenes (Landsat 4 to 8 missions, from path 197 to 202 and from rows 30 to 34), and 52 Landsat WRS1 scenes (for the previous Landsat missions, 212 to 221 and 30 to 34). Therefore, a mean of 49.5 Landsat scenes, 8 quinquennia per scene and a about 6 dates per quinquennium , from 1975 to present, produces around 2376 sets resulting in 30 m x 30 m spatial resolution maps. Each set is composed by highly coherent geometric and radiometric multispectral and multitemporal (to account for phenology) imagery as well as vegetation and wetness indexes, and several derived topographic information (about 10 Tbyte of data). Furthermore, on the basis on a previous work: the Digital Climatic Atlas of

Editorial: Focus on X-ray Beams with High Coherence

NASA Astrophysics Data System (ADS)

Robinson, Ian; Gruebel, Gerhard; Mochrie, Simon

2010-03-01

/Pd multilayer films K A Seu, R Su, S Roy, D Parks, E Shipton, E E Fullerton and S D Kevan Holographic and diffractive x-ray imaging using waveguides as quasi-point sources K Giewekemeyer, H Neubauer, S Kalbfleisch, S P Krüger and T Salditt Mapping the conformations of biological assemblies P Schwander, R Fung, G N Phillips Jr and A Ourmazd Imaging the displacement field within epitaxial nanostructures by coherent diffraction: a feasibility study Ana Diaz, Virginie Chamard, Cristian Mocuta, Rogerio Magalhães-Paniago, Julian Stangl, Dina Carbone, Till H Metzger and Günther Bauer The potential for two-dimensional crystallography of membrane proteins at future x-ray free-electron laser sources Cameron M Kewish, Pierre Thibault, Oliver Bunk and Franz Pfeiffer Coherence properties of hard x-ray synchrotron sources and x-ray free-electron lasers I A Vartanyants and A Singer Coherent imaging of biological samples with femtosecond pulses at the free-electron laser FLASH A P Mancuso, Th Gorniak, F Staier, O M Yefanov, R Barth, C Christophis, B Reime, J Gulden, A Singer, M E Pettit, Th Nisius, Th Wilhein, C Gutt, G Grübel, N Guerassimova, R Treusch, J Feldhaus, S Eisebitt, E Weckert, M Grunze, A Rosenhahn and I A Vartanyants