NASADIG - NASA DEVICE INDEPENDENT GRAPHICS LIBRARY (AMDAHL VERSION)

NASA Technical Reports Server (NTRS)

Rogers, J. E.

1994-01-01

The NASA Device Independent Graphics Library, NASADIG, can be used with many computer-based engineering and management applications. The library gives the user the opportunity to translate data into effective graphic displays for presentation. The software offers many features which allow the user flexibility in creating graphics. These include two-dimensional plots, subplot projections in 3D-space, surface contour line plots, and surface contour color-shaded plots. Routines for three-dimensional plotting, wireframe surface plots, surface plots with hidden line removal, and surface contour line plots are provided. Other features include polar and spherical coordinate plotting, world map plotting utilizing either cylindrical equidistant or Lambert equal area projection, plot translation, plot rotation, plot blowup, splines and polynomial interpolation, area blanking control, multiple log/linear axes, legends and text control, curve thickness control, and multiple text fonts (18 regular, 4 bold). NASADIG contains several groups of subroutines. Included are subroutines for plot area and axis definition; text set-up and display; area blanking; line style set-up, interpolation, and plotting; color shading and pattern control; legend, text block, and character control; device initialization; mixed alphabets setting; and other useful functions. The usefulness of many routines is dependent on the prior definition of basic parameters. The program's control structure uses a serial-level construct with each routine restricted for activation at some prescribed level(s) of problem definition. NASADIG provides the following output device drivers: Selanar 100XL, VECTOR Move/Draw ASCII and PostScript files, Tektronix 40xx, 41xx, and 4510 Rasterizer, DEC VT-240 (4014 mode), IBM AT/PC compatible with SmartTerm 240 emulator, HP Lasergrafix Film Recorder, QMS 800/1200, DEC LN03+ Laserprinters, and HP LaserJet (Series III). NASADIG is written in FORTRAN and is available for several platforms. NASADIG 5.7 is available for DEC VAX series computers running VMS 5.0 or later (MSC-21801), Cray X-MP and Y-MP series computers running UNICOS (COS-10049), and Amdahl 5990 mainframe computers running UTS (COS-10050). NASADIG 5.1 is available for UNIX-based operating systems (MSC-22001). The UNIX version has been successfully implemented on Sun4 series computers running SunOS, SGI IRIS computers running IRIX, Hewlett Packard 9000 computers running HP-UX, and Convex computers running Convex OS (MSC-22001). The standard distribution medium for MSC-21801 is a set of two 6250 BPI 9-track magnetic tapes in DEC VAX BACKUP format. It is also available on a set of two TK50 tape cartridges in DEC VAX BACKUP format. The standard distribution medium for COS-10049 and COS-10050 is a 6250 BPI 9-track magnetic tape in UNIX tar format. Other distribution media and formats may be available upon request. The standard distribution medium for MSC-22001 is a .25 inch streaming magnetic tape cartridge (Sun QIC-24) in UNIX tar format. Alternate distribution media and formats are available upon request. With minor modification, the UNIX source code can be ported to other platforms including IBM PC/AT series computers and compatibles. NASADIG is also available bundled with TRASYS, the Thermal Radiation Analysis System (COS-10026, DEC VAX version; COS-10040, CRAY version).

NASADIG - NASA DEVICE INDEPENDENT GRAPHICS LIBRARY (UNIX VERSION)

NASA Technical Reports Server (NTRS)

Rogers, J. E.

1994-01-01

The NASA Device Independent Graphics Library, NASADIG, can be used with many computer-based engineering and management applications. The library gives the user the opportunity to translate data into effective graphic displays for presentation. The software offers many features which allow the user flexibility in creating graphics. These include two-dimensional plots, subplot projections in 3D-space, surface contour line plots, and surface contour color-shaded plots. Routines for three-dimensional plotting, wireframe surface plots, surface plots with hidden line removal, and surface contour line plots are provided. Other features include polar and spherical coordinate plotting, world map plotting utilizing either cylindrical equidistant or Lambert equal area projection, plot translation, plot rotation, plot blowup, splines and polynomial interpolation, area blanking control, multiple log/linear axes, legends and text control, curve thickness control, and multiple text fonts (18 regular, 4 bold). NASADIG contains several groups of subroutines. Included are subroutines for plot area and axis definition; text set-up and display; area blanking; line style set-up, interpolation, and plotting; color shading and pattern control; legend, text block, and character control; device initialization; mixed alphabets setting; and other useful functions. The usefulness of many routines is dependent on the prior definition of basic parameters. The program's control structure uses a serial-level construct with each routine restricted for activation at some prescribed level(s) of problem definition. NASADIG provides the following output device drivers: Selanar 100XL, VECTOR Move/Draw ASCII and PostScript files, Tektronix 40xx, 41xx, and 4510 Rasterizer, DEC VT-240 (4014 mode), IBM AT/PC compatible with SmartTerm 240 emulator, HP Lasergrafix Film Recorder, QMS 800/1200, DEC LN03+ Laserprinters, and HP LaserJet (Series III). NASADIG is written in FORTRAN and is available for several platforms. NASADIG 5.7 is available for DEC VAX series computers running VMS 5.0 or later (MSC-21801), Cray X-MP and Y-MP series computers running UNICOS (COS-10049), and Amdahl 5990 mainframe computers running UTS (COS-10050). NASADIG 5.1 is available for UNIX-based operating systems (MSC-22001). The UNIX version has been successfully implemented on Sun4 series computers running SunOS, SGI IRIS computers running IRIX, Hewlett Packard 9000 computers running HP-UX, and Convex computers running Convex OS (MSC-22001). The standard distribution medium for MSC-21801 is a set of two 6250 BPI 9-track magnetic tapes in DEC VAX BACKUP format. It is also available on a set of two TK50 tape cartridges in DEC VAX BACKUP format. The standard distribution medium for COS-10049 and COS-10050 is a 6250 BPI 9-track magnetic tape in UNIX tar format. Other distribution media and formats may be available upon request. The standard distribution medium for MSC-22001 is a .25 inch streaming magnetic tape cartridge (Sun QIC-24) in UNIX tar format. Alternate distribution media and formats are available upon request. With minor modification, the UNIX source code can be ported to other platforms including IBM PC/AT series computers and compatibles. NASADIG is also available bundled with TRASYS, the Thermal Radiation Analysis System (COS-10026, DEC VAX version; COS-10040, CRAY version).

GEMPAK 5.1 - A GENERAL METEOROLOGICAL PACKAGE (UNIX VERSION)

NASA Technical Reports Server (NTRS)

Desjardins, M. L.

1994-01-01

GEMPAK is a general meteorological software package developed at NASA/Goddard Space Flight Center. It includes programs to analyze and display surface, upper-air, and gridded data, including model output. There are very general programs to list, edit, and plot data on maps, to display profiles and time series, to draw and fill contours, to draw streamlines, to plot symbols for clouds, sky cover, and pressure tendency, and draw cross sections in the case of gridded data and sounding data. In addition, there are Barnes objective analysis programs to grid surface and upper-air data. The programs include the capabilities to derive meteorological parameters from those found in the dataset, to perform vertical interpolations of sounding data to different coordinate systems, and to compute an extensive set of gridded diagnostic quantities by specifying various nested combinations of scalars and vector arithmetic, algebraic, and differential operators. The GEMPAK 5.1 graphics/transformation subsystem, GEMPLT, provides device-independent graphics. GEMPLT also has the capability to display output in a variety of map projections or overlaid on satellite imagery. GEMPAK 5.1 is written in FORTRAN 77 and C-language and has been implemented on VAX computers under VMS and on computers running the UNIX operating system. During installation and normal use, this package occupies approximately 100Mb of hard disk space. The UNIX version of GEMPAK includes drivers for several graphic output systems including MIT's X Window System (X11,R4), Sun GKS, PostScript (color and monochrome), Silicon Graphics, and others. The VMS version of GEMPAK also includes drivers for several graphic output systems including PostScript (color and monochrome). The VMS version is delivered with the object code for the Transportable Applications Environment (TAE) program, version 4.1 which serves as a user interface. A color monitor is recommended for displaying maps on video display devices. Data for rendering regional maps is included with this package. The standard distribution medium for the UNIX version of GEMPAK 5.1 is a .25 inch streaming magnetic tape cartridge in UNIX tar format. The standard distribution medium for the VMS version of GEMPAK 5.1 is a 6250 BPI 9-track magnetic tape in DEC VAX BACKUP format. The VMS version is also available on a TK50 tape cartridge in DEC VAX BACKUP format. This program was developed in 1985. The current version, GEMPAK 5.1, was released in 1992. The package is delivered with source code. An extensive collection of subroutine libraries allows users to format data for use by GEMPAK, to develop new programs, and to enhance existing ones.

LAS - LAND ANALYSIS SYSTEM, VERSION 5.0

NASA Technical Reports Server (NTRS)

Pease, P. B.

1994-01-01

The Land Analysis System (LAS) is an image analysis system designed to manipulate and analyze digital data in raster format and provide the user with a wide spectrum of functions and statistical tools for analysis. LAS offers these features under VMS with optional image display capabilities for IVAS and other display devices as well as the X-Windows environment. LAS provides a flexible framework for algorithm development as well as for the processing and analysis of image data. Users may choose between mouse-driven commands or the traditional command line input mode. LAS functions include supervised and unsupervised image classification, film product generation, geometric registration, image repair, radiometric correction and image statistical analysis. Data files accepted by LAS include formats such as Multi-Spectral Scanner (MSS), Thematic Mapper (TM) and Advanced Very High Resolution Radiometer (AVHRR). The enhanced geometric registration package now includes both image to image and map to map transformations. The over 200 LAS functions fall into image processing scenario categories which include: arithmetic and logical functions, data transformations, fourier transforms, geometric registration, hard copy output, image restoration, intensity transformation, multispectral and statistical analysis, file transfer, tape profiling and file management among others. Internal improvements to the LAS code have eliminated the VAX VMS dependencies and improved overall system performance. The maximum LAS image size has been increased to 20,000 lines by 20,000 samples with a maximum of 256 bands per image. The catalog management system used in earlier versions of LAS has been replaced by a more streamlined and maintenance-free method of file management. This system is not dependent on VAX/VMS and relies on file naming conventions alone to allow the use of identical LAS file names on different operating systems. While the LAS code has been improved, the original capabilities of the system have been preserved. These include maintaining associated image history, session logging, and batch, asynchronous and interactive mode of operation. The LAS application programs are integrated under version 4.1 of an interface called the Transportable Applications Executive (TAE). TAE 4.1 has four modes of user interaction: menu, direct command, tutor (or help), and dynamic tutor. In addition TAE 4.1 allows the operation of LAS functions using mouse-driven commands under the TAE-Facelift environment provided with TAE 4.1. These modes of operation allow users, from the beginner to the expert, to exercise specific application options. LAS is written in C-language and FORTRAN 77 for use with DEC VAX computers running VMS with approximately 16Mb of physical memory. This program runs under TAE 4.1. Since TAE 4.1 is not a current version of TAE, TAE 4.1 is included within the LAS distribution. Approximately 130,000 blocks (65Mb) of disk storage space are necessary to store the source code and files generated by the installation procedure for LAS and 44,000 blocks (22Mb) of disk storage space are necessary for TAE 4.1 installation. The only other dependencies for LAS are the subroutine libraries for the specific display device(s) that will be used with LAS/DMS (e.g. X-Windows and/or IVAS). The standard distribution medium for LAS is a set of two 9track 6250 BPI magnetic tapes in DEC VAX BACKUP format. It is also available on a set of two TK50 tape cartridges in DEC VAX BACKUP format. This program was developed in 1986 and last updated in 1992.

MATH77 - A LIBRARY OF MATHEMATICAL SUBPROGRAMS FOR FORTRAN 77, RELEASE 4.0

NASA Technical Reports Server (NTRS)

Lawson, C. L.

1994-01-01

MATH77 is a high quality library of ANSI FORTRAN 77 subprograms implementing contemporary algorithms for the basic computational processes of science and engineering. The portability of MATH77 meets the needs of present-day scientists and engineers who typically use a variety of computing environments. Release 4.0 of MATH77 contains 454 user-callable and 136 lower-level subprograms. Usage of the user-callable subprograms is described in 69 sections of the 416 page users' manual. The topics covered by MATH77 are indicated by the following list of chapter titles in the users' manual: Mathematical Functions, Pseudo-random Number Generation, Linear Systems of Equations and Linear Least Squares, Matrix Eigenvalues and Eigenvectors, Matrix Vector Utilities, Nonlinear Equation Solving, Curve Fitting, Table Look-Up and Interpolation, Definite Integrals (Quadrature), Ordinary Differential Equations, Minimization, Polynomial Rootfinding, Finite Fourier Transforms, Special Arithmetic , Sorting, Library Utilities, Character-based Graphics, and Statistics. Besides subprograms that are adaptations of public domain software, MATH77 contains a number of unique packages developed by the authors of MATH77. Instances of the latter type include (1) adaptive quadrature, allowing for exceptional generality in multidimensional cases, (2) the ordinary differential equations solver used in spacecraft trajectory computation for JPL missions, (3) univariate and multivariate table look-up and interpolation, allowing for "ragged" tables, and providing error estimates, and (4) univariate and multivariate derivative-propagation arithmetic. MATH77 release 4.0 is a subroutine library which has been carefully designed to be usable on any computer system that supports the full ANSI standard FORTRAN 77 language. It has been successfully implemented on a CRAY Y/MP computer running UNICOS, a UNISYS 1100 computer running EXEC 8, a DEC VAX series computer running VMS, a Sun4 series computer running SunOS, a Hewlett-Packard 720 computer running HP-UX, a Macintosh computer running MacOS, and an IBM PC compatible computer running MS-DOS. Accompanying the library is a set of 196 "demo" drivers that exercise all of the user-callable subprograms. The FORTRAN source code for MATH77 comprises 109K lines of code in 375 files with a total size of 4.5Mb. The demo drivers comprise 11K lines of code and 418K. Forty-four percent of the lines of the library code and 29% of those in the demo code are comment lines. The standard distribution medium for MATH77 is a .25 inch streaming magnetic tape cartridge in UNIX tar format. It is also available on a 9track 1600 BPI magnetic tape in VAX BACKUP format and a TK50 tape cartridge in VAX BACKUP format. An electronic copy of the documentation is included on the distribution media. Previous releases of MATH77 have been used over a number of years in a variety of JPL applications. MATH77 Release 4.0 was completed in 1992. MATH77 is a copyrighted work with all copyright vested in NASA.

NPLOT - NASTRAN PLOT

NASA Technical Reports Server (NTRS)

Mcentire, K.

1994-01-01

NPLOT is an interactive computer graphics program for plotting undeformed and deformed NASTRAN finite element models (FEMs). Although there are many commercial codes already available for plotting FEMs, these have limited use due to their cost, speed, and lack of features to view BAR elements. NPLOT was specifically developed to overcome these limitations. On a vector type graphics device the two best ways to show depth are by hidden line plotting or haloed line plotting. A hidden line algorithm generates views of models with all hidden lines removed, and a haloed line algorithm displays views with aft lines broken in order to show depth while keeping the entire model visible. A haloed line algorithm is especially useful for plotting models composed of many line elements and few surface elements. The most important feature of NPLOT is its ability to create both hidden line and haloed line views accurately and much more quickly than with any other existing hidden or haloed line algorithms. NPLOT is also capable of plotting a normal wire frame view to display all lines of a model. NPLOT is able to aid in viewing all elements, but it has special features not generally available for plotting BAR elements. These features include plotting of TRUE LENGTH and NORMALIZED offset vectors and orientation vectors. Standard display operations such as rotation and perspective are possible, but different view planes such as X-Y, Y-Z, and X-Z may also be selected. Another display option is the Z-axis cut which allows a portion of the fore part of the model to be cut away to reveal details of the inside of the model. A zoom function is available to terminals with a locator (graphics cursor, joystick, etc.). The user interface of NPLOT is designed to make the program quick and easy to use. A combination of menus and commands with help menus for detailed information about each command allows experienced users greater speed and efficiency. Once a plot is on the screen the interface becomes command driven, enabling the user to manipulate the display or execute a command without having to return to the menu. NPLOT is also able to plot deformed shapes allowing it to perform post-processing. The program can read displacements, either static displacements or eigenvectors, from a MSC/NASTRAN F06 file or a UAI/NASTRAN PRT file. The displacements are written into a unformatted scratch file where they are available for rapid access when the user wishes to display a deformed shape. All subcases or mode shapes can be read in at once. Then it is easy to enable the deformed shape, to change subcases or mode shapes and to change the scale factor for subsequent plots. NPLOT is written in VAX FORTRAN for DEC VAX series computers running VMS. As distributed, the NPLOT source code makes calls to the DI3000 graphics package from Precision Visuals; however, a set of interface routines is provided to translate the DI3000 calls into Tektronix PLOT10/TCS graphics library calls so that NPLOT can use the standard Tektronix 4010 which many PC terminal emulation software programs support. NPLOT is available in VAX BACKUP format on a 9-track 1600 BPI DEC VAX BACKUP format magnetic tape (standard media) or a TK50 tape cartridge. This program was developed in 1991. DEC, VAX, VMS, and TK50 are trademarks of Digital Equipment Corporation. Tektronix, PLOT10, and TCS are trademarks of Tektronix, Inc. DI3000 is a registered trademark of Precision Visuals, Inc. NASTRAN is a registered trademark of the National Aeronautics and Space Administration. MSC/ is a trademark of MacNeal-Schwendler Corporation. UAI is a trademark of Universal Analytics, Inc.

PATHWAYS - ELECTRON TUNNELING PATHWAYS IN PROTEINS

NASA Technical Reports Server (NTRS)

Beratan, D. N.

1994-01-01

The key to understanding the mechanisms of many important biological processes such as photosynthesis and respiration is a better understanding of the electron transfer processes which take place between metal atoms (and other groups) fixed within large protein molecules. Research is currently focused on the rate of electron transfer and the factors that influence it, such as protein composition and the distance between metal atoms. Current models explain the swift transfer of electrons over considerable distances by postulating bridge-mediated tunneling, or physical tunneling pathways, made up of interacting bonds in the medium around and between donor and acceptor sites. The program PATHWAYS is designed to predict the route along which electrons travel in the transfer processes. The basic strategy of PATHWAYS is to begin by recording each possible path element on a connectivity list, including in each entry which two atoms are connected and what contribution the connection would make to the overall rate if it were included in a pathway. The list begins with the bonded molecular structure (including the backbone sequence and side chain connectivity), and then adds probable hydrogen bond links and through-space contacts. Once this list is completed, the program runs a tree search from the donor to the acceptor site to find the dominant pathways. The speed and efficiency of the computer search offers an improvement over manual techniques. PATHWAYS is written in FORTRAN 77 for execution on DEC VAX series computers running VMS. The program inputs data from four data sets and one structure file. The software was written to input BIOGRAF (old format) structure files based on x-ray crystal structures and outputs ASCII files listing the best pathways and BIOGRAF vector files containing the paths. Relatively minor changes could be made in the input format statements for compatibility with other graphics software. The executable and source code are included with the distribution. The main memory requirement for execution is 2.6 Mb. This program is available in DEC VAX BACKUP format on a 9-track 1600 BPI magnetic tape (standard distribution) or on a TK50 tape cartridge. PATHWAYS was developed in 1988. PATHWAYS is a copyrighted work with all copyright vested in NASA. DEC, VAX, VMS, and TK50 are trademarks of Digital Equipment Corporation. BIOGRAF is a trademark of Molecular Simulations, Inc., Sunnyvale, CA.

libvaxdata: VAX data format conversion routines

USGS Publications Warehouse

Baker, Lawrence M.

2005-01-01

libvaxdata provides a collection of routines for converting numeric data-integer and floating-point-to and from the formats used on a Digital Equipment Corporation1 (DEC) VAX 32-bit minicomputer (Brunner, 1991). Since the VAX numeric data formats are inherited from those used on a DEC PDP-11 16-bit minicomputer, these routines can be used to convert PDP-11 data as well. VAX numeric data formats are also the default data formats used on DEC Alpha 64-bit minicomputers running OpenVMS The libvaxdata routines are callable from Fortran or C. They require that the caller use two's-complement format for integer data and IEEE 754 format (ANSI/IEEE, 1985) for floating-point data. They also require that the 'natural' size of a C int type (integer) is 32 bits. That is the case for most modern 32-bit and 64-bit computer systems. Nevertheless, you may wish to consult the Fortran or C compiler documentation on your system to be sure. Some Fortran compilers support conversion of VAX numeric data on-the-fly when reading or writing unformatted files, either as a compiler option or a run-time I/O option. This feature may be easier to use than the libvaxdata routines. Consult the Fortran compiler documentation on your system to determine if this alternative is available to you. 1Later Compaq Computer Corporation, now Hewlett-Packard Company

DFACS - DATABASE, FORMS AND APPLICATIONS FOR CABLING AND SYSTEMS, VERSION 3.30

NASA Technical Reports Server (NTRS)

Billitti, J. W.

1994-01-01

DFACS is an interactive multi-user computer-aided engineering tool for system level electrical integration and cabling engineering. The purpose of the program is to provide the engineering community with a centralized database for entering and accessing system functional definitions, subsystem and instrument-end circuit pinout details, and harnessing data. The primary objective is to provide an instantaneous single point of information interchange, thus avoiding error-prone, time-consuming, and costly multiple-path data shuttling. The DFACS program, which is centered around a single database, has built-in menus that provide easy data input and access for all involved system, subsystem, and cabling personnel. The DFACS program allows parallel design of circuit data sheets and harness drawings. It also recombines raw information to automatically generate various project documents and drawings including the Circuit Data Sheet Index, the Electrical Interface Circuits List, Assembly and Equipment Lists, Electrical Ground Tree, Connector List, Cable Tree, Cabling Electrical Interface and Harness Drawings, Circuit Data Sheets, and ECR List of Affected Interfaces/Assemblies. Real time automatic production of harness drawings and circuit data sheets from the same data reservoir ensures instant system and cabling engineering design harmony. DFACS also contains automatic wire routing procedures and extensive error checking routines designed to minimize the possibility of engineering error. DFACS is designed to run on DEC VAX series computers under VMS using Version 6.3/01 of INGRES QUEL/OSL, a relational database system which is available through Relational Technology, Inc. The program is available in VAX BACKUP format on a 1600 BPI 9-track magnetic tape (standard media) or a TK50 tape cartridge. DFACS was developed in 1987 and last updated in 1990. DFACS is a copyrighted work with all copyright vested in NASA. DEC, VAX and VMS are trademarks of Digital Equipment Corporation. INGRES QUEL/OSL is a trademark of Relational Technology, Inc.

EASI - EQUILIBRIUM AIR SHOCK INTERFERENCE

NASA Technical Reports Server (NTRS)

Glass, C. E.

1994-01-01

New research on hypersonic vehicles, such as the National Aero-Space Plane (NASP), has raised concerns about the effects of shock-wave interference on various structural components of the craft. State-of-the-art aerothermal analysis software is inadequate to predict local flow and heat flux in areas of extremely high heat transfer, such as the surface impingement of an Edney-type supersonic jet. EASI revives and updates older computational methods for calculating inviscid flow field and maximum heating from shock wave interference. The program expands these methods to solve problems involving the six shock-wave interference patterns on a two-dimensional cylindrical leading edge with an equilibrium chemically reacting gas mixture (representing, for example, the scramjet cowl of the NASP). The inclusion of gas chemistry allows for a more accurate prediction of the maximum pressure and heating loads by accounting for the effects of high temperature on the air mixture. Caloric imperfections and specie dissociation of high-temperature air cause shock-wave angles, flow deflection angles, and thermodynamic properties to differ from those calculated by a calorically perfect gas model. EASI contains pressure- and temperature-dependent thermodynamic and transport properties to determine heating rates, and uses either a calorically perfect air model or an 11-specie, 7-reaction reacting air model at equilibrium with temperatures up to 15,000 K for the inviscid flowfield calculations. EASI solves the flow field and the associated maximum surface pressure and heat flux for the six common types of shock wave interference. Depending on the type of interference, the program solves for shock-wave/boundary-layer interaction, expansion-fan/boundary-layer interaction, attaching shear layer or supersonic jet impingement. Heat flux predictions require a knowledge (from experimental data or relevant calculations) of a pertinent length scale of the interaction. Output files contain flow-field information for the various shock-wave interference patterns and their associated maximum surface pressure and heat flux predictions. EASI is written in FORTRAN 77 for a DEC VAX 8500 series computer using the VAX/VMS operating system, and requires 75K of memory. The program is available on a 9-track 1600 BPI magnetic tape in DEC VAX BACKUP format. EASI was developed in 1989. DEC, VAX, and VMS are registered trademarks of the Digital Equipment Corporation.

MIST - MINIMUM-STATE METHOD FOR RATIONAL APPROXIMATION OF UNSTEADY AERODYNAMIC FORCE COEFFICIENT MATRICES

NASA Technical Reports Server (NTRS)

Karpel, M.

1994-01-01

Various control analysis, design, and simulation techniques of aeroservoelastic systems require the equations of motion to be cast in a linear, time-invariant state-space form. In order to account for unsteady aerodynamics, rational function approximations must be obtained to represent them in the first order equations of the state-space formulation. A computer program, MIST, has been developed which determines minimum-state approximations of the coefficient matrices of the unsteady aerodynamic forces. The Minimum-State Method facilitates the design of lower-order control systems, analysis of control system performance, and near real-time simulation of aeroservoelastic phenomena such as the outboard-wing acceleration response to gust velocity. Engineers using this program will be able to calculate minimum-state rational approximations of the generalized unsteady aerodynamic forces. Using the Minimum-State formulation of the state-space equations, they will be able to obtain state-space models with good open-loop characteristics while reducing the number of aerodynamic equations by an order of magnitude more than traditional approaches. These low-order state-space mathematical models are good for design and simulation of aeroservoelastic systems. The computer program, MIST, accepts tabular values of the generalized aerodynamic forces over a set of reduced frequencies. It then determines approximations to these tabular data in the LaPlace domain using rational functions. MIST provides the capability to select the denominator coefficients in the rational approximations, to selectably constrain the approximations without increasing the problem size, and to determine and emphasize critical frequency ranges in determining the approximations. MIST has been written to allow two types data weighting options. The first weighting is a traditional normalization of the aerodynamic data to the maximum unit value of each aerodynamic coefficient. The second allows weighting the importance of different tabular values in determining the approximations based upon physical characteristics of the system. Specifically, the physical weighting capability is such that each tabulated aerodynamic coefficient, at each reduced frequency value, is weighted according to the effect of an incremental error of this coefficient on aeroelastic characteristics of the system. In both cases, the resulting approximations yield a relatively low number of aerodynamic lag states in the subsequent state-space model. MIST is written in ANSI FORTRAN 77 for DEC VAX series computers running VMS. It requires approximately 1Mb of RAM for execution. The standard distribution medium for this package is a 9-track 1600 BPI magnetic tape in DEC VAX FILES-11 format. It is also available on a TK50 tape cartridge in DEC VAX BACKUP format. MIST was developed in 1991. DEC VAX and VMS are trademarks of Digital Equipment Corporation. FORTRAN 77 is a registered trademark of Lahey Computer Systems, Inc.

Friendly Neighborhood Computer Project. Extension of the IBM NJE network to DEC VAX computers

DOE Office of Scientific and Technical Information (OSTI.GOV)

Raffenetti, R.C.; Bertoncini, P.J.; Engert, D.E.

1984-07-01

This manual is divided into six chapters. The first is an overview of the VAX NJE emulator system and describes what can be done with the VAX NJE emulator software. The second chapter describes the commands that users of the VAX systems will use. Each command description includes the format of the command, a list of valid options and parameters and their meanings, and several short examples of command use. The third chapter describes the commands and capabilities for sending general, sequential files from and to VAX VMS nodes. The fourth chapter describes how to transmit data to a VAXmore » from other computer systems on the network. The fifth chapter explains how to exchange electronic mail with IBM CMS users and with users of other VAX VMS systems connected by NJE communications. The sixth chapter describes operator procedures and the additional commands operators may use.« less

FLUSH - PREDICTION OF FLOW PARAMETERS OF SLUSH HYDROGEN

NASA Technical Reports Server (NTRS)

Hardy, T.

1994-01-01

Slush hydrogen, a mixture of the solid and liquid phases of hydrogen, is a possible source of fuel for the National Aerospace Plane (NASP) Project. Advantages of slush hydrogen over liquid hydrogen include greater heat capacity and greater density. However, practical use of slush hydrogen as a fuel requires systems of lines, valves, etc. which are designed to deliver the fuel in slush form with minimal solid loss as a result of pipe heating or flow friction. Engineers involved with the NASP Project developed FLUSH to calculate the pressure drop and slush hydrogen solid fraction loss for steady-state, one-dimensional flow. FLUSH solves the steady-state, one-dimensional energy equation and the Bernoulli equation for pipe flow. The program performs these calculations for each two-node element--straight pipe length, elbow, valve, fitting, or other part of the piping system--specified by the user. The user provides flow rate, upstream pressure, initial solid hydrogen fraction, element heat leak, and element parameters such as length and diameter. For each element, FLUSH first calculates the pressure drop, then figures the slush solid fraction exiting the element. The code employs GASPLUS routines to calculate thermodynamic properties for the slush hydrogen. FLUSH is written in FORTRAN IV for DEC VAX series computers running VMS. An executable is provided on the tape. The GASPLUS physical properties routines which are required for building the executable are included as one object library on the program media (full source code for GASPLUS is available separately as COSMIC Program Number LEW-15091). FLUSH is available in DEC VAX BACKUP format on a 9-track 1600 BPI magnetic tape (standard media) or on a TK50 tape cartridge. FLUSH was developed in 1989.

CARES - CERAMICS ANALYSIS AND RELIABILITY EVALUATION OF STRUCTURES

NASA Technical Reports Server (NTRS)

Nemeth, N. N.

1994-01-01

The beneficial properties of structural ceramics include their high-temperature strength, light weight, hardness, and corrosion and oxidation resistance. For advanced heat engines, ceramics have demonstrated functional abilities at temperatures well beyond the operational limits of metals. This is offset by the fact that ceramic materials tend to be brittle. When a load is applied, their lack of significant plastic deformation causes the material to crack at microscopic flaws, destroying the component. CARES calculates the fast-fracture reliability or failure probability of macroscopically isotropic ceramic components. These components may be subjected to complex thermomechanical loadings. The program uses results from a commercial structural analysis program (MSC/NASTRAN or ANSYS) to evaluate component reliability due to inherent surface and/or volume type flaws. A multiple material capability allows the finite element model reliability to be a function of many different ceramic material statistical characterizations. The reliability analysis uses element stress, temperature, area, and volume output, which are obtained from two dimensional shell and three dimensional solid isoparametric or axisymmetric finite elements. CARES utilizes the Batdorf model and the two-parameter Weibull cumulative distribution function to describe the effects of multi-axial stress states on material strength. The shear-sensitive Batdorf model requires a user-selected flaw geometry and a mixed-mode fracture criterion. Flaws intersecting the surface and imperfections embedded in the volume can be modeled. The total strain energy release rate theory is used as a mixed mode fracture criterion for co-planar crack extension. Out-of-plane crack extension criteria are approximated by a simple equation with a semi-empirical constant that can model the maximum tangential stress theory, the minimum strain energy density criterion, the maximum strain energy release rate theory, or experimental results. For comparison, Griffith's maximum tensile stress theory, the principle of independent action, and the Weibull normal stress averaging models are also included. Weibull material strength parameters, the Batdorf crack density coefficient, and other related statistical quantities are estimated from four-point bend bar or uniform uniaxial tensile specimen fracture strength data. Parameter estimation can be performed for single or multiple failure modes by using the least-squares analysis or the maximum likelihood method. A more limited program, CARES/PC (COSMIC number LEW-15248) runs on a personal computer and estimates ceramic material properties from three-point bend bar data. CARES/PC does not perform fast fracture reliability estimation. CARES is written in FORTRAN 77 and has been implemented on DEC VAX series computers under VMS and on IBM 370 series computers under VM/CMS. On a VAX, CARES requires 10Mb of main memory. Five MSC/NASTRAN example problems and two ANSYS example problems are provided. There are two versions of CARES supplied on the distribution tape, CARES1 and CARES2. CARES2 contains sub-elements and CARES1 does not. CARES is available on a 9-track 1600 BPI VAX FILES-11 format magnetic tape (standard media) or in VAX BACKUP format on a TK50 tape cartridge. The program requires a FORTRAN 77 compiler and about 12Mb memory. CARES was developed in 1990. DEC, VAX and VMS are trademarks of Digital Equipment Corporation. IBM 370 is a trademark of International Business Machines. MSC/NASTRAN is a trademark of MacNeal-Schwendler Corporation. ANSYS is a trademark of Swanson Analysis Systems, Inc.

IMAGEP - A FORTRAN ALGORITHM FOR DIGITAL IMAGE PROCESSING

NASA Technical Reports Server (NTRS)

Roth, D. J.

1994-01-01

IMAGEP is a FORTRAN computer algorithm containing various image processing, analysis, and enhancement functions. It is a keyboard-driven program organized into nine subroutines. Within the subroutines are other routines, also, selected via keyboard. Some of the functions performed by IMAGEP include digitization, storage and retrieval of images; image enhancement by contrast expansion, addition and subtraction, magnification, inversion, and bit shifting; display and movement of cursor; display of grey level histogram of image; and display of the variation of grey level intensity as a function of image position. This algorithm has possible scientific, industrial, and biomedical applications in material flaw studies, steel and ore analysis, and pathology, respectively. IMAGEP is written in VAX FORTRAN for DEC VAX series computers running VMS. The program requires the use of a Grinnell 274 image processor which can be obtained from Mark McCloud Associates, Campbell, CA. An object library of the required GMR series software is included on the distribution media. IMAGEP requires 1Mb of RAM for execution. The standard distribution medium for this program is a 1600 BPI 9track magnetic tape in VAX FILES-11 format. It is also available on a TK50 tape cartridge in VAX FILES-11 format. This program was developed in 1991. DEC, VAX, VMS, and TK50 are trademarks of Digital Equipment Corporation.

NASA ARCH- A FILE ARCHIVAL SYSTEM FOR THE DEC VAX

NASA Technical Reports Server (NTRS)

Scott, P. J.

1994-01-01

The function of the NASA ARCH system is to provide a permanent storage area for files that are infrequently accessed. The NASA ARCH routines were designed to provide a simple mechanism by which users can easily store and retrieve files. The user treats NASA ARCH as the interface to a black box where files are stored. There are only five NASA ARCH user commands, even though NASA ARCH employs standard VMS directives and the VAX BACKUP utility. Special care is taken to provide the security needed to insure file integrity over a period of years. The archived files may exist in any of three storage areas: a temporary buffer, the main buffer, and a magnetic tape library. When the main buffer fills up, it is transferred to permanent magnetic tape storage and deleted from disk. Files may be restored from any of the three storage areas. A single file, multiple files, or entire directories can be stored and retrieved. archived entities hold the same name, extension, version number, and VMS file protection scheme as they had in the user's account prior to archival. NASA ARCH is capable of handling up to 7 directory levels. Wildcards are supported. User commands include TEMPCOPY, DISKCOPY, DELETE, RESTORE, and DIRECTORY. The DIRECTORY command searches a directory of savesets covering all three archival areas, listing matches according to area, date, filename, or other criteria supplied by the user. The system manager commands include 1) ARCHIVE- to transfer the main buffer to duplicate magnetic tapes, 2) REPORTto determine when the main buffer is full enough to archive, 3) INCREMENT- to back up the partially filled main buffer, and 4) FULLBACKUP- to back up the entire main buffer. On-line help files are provided for all NASA ARCH commands. NASA ARCH is written in DEC VAX DCL for interactive execution and has been implemented on a DEC VAX computer operating under VMS 4.X. This program was developed in 1985.

FROST - FREEDOM OPERATIONS SIMULATION TEST VERSION 1.0

NASA Technical Reports Server (NTRS)

Deshpande, G. K.

1994-01-01

The Space Station Freedom Information System processes and transmits data between the space station and the station controllers and payload operators on the ground. Components of the system include flight hardware, communications satellites, software and ground facilities. FROST simulates operation of the SSF Information System, tracking every data packet from generation to destination for both uplinks and downlinks. This program collects various statistics concerning the SSF Information System operation and provides reports of these at user-specified intervals. Additionally, FROST has graphical display capability to enhance interpretation of these statistics. FROST models each of the components of the SSF Information System as an object, to which packets are generated, received, processed, transmitted, and/or dumped. The user must provide the information system design with specified parameters and inter-connections among objects. To aid this process, FROST supplies an example SSF Information System for simulation, but this example must be copied before it is changed and used for further simulation. Once specified, system architecture and parameters are put into the input file, named the Test Configuration Definition (TCD) file. Alternative system designs can then be simulated simply by editing the TCD file. Within this file the user can define new objects, alter object parameters, redefine paths, redefine generation rates and windows, and redefine object interconnections. At present, FROST does not model every feature of the SSF Information System, but it is capable of simulating many of the system's important functions. To generate data messages, which can come from any object, FROST defines "windows" to specify when, what kind, and how much of that data is generated. All messages are classified by priority as either (1)emergency (2)quick look (3)telemetry or (4)payload data. These messages are processed by all objects according to priority. That is, all priority 1 (emergency) messages are processed and transmitted before priority 2 messages, and so forth. FROST also allows for specification of "pipeline" or "direct" links. Pipeline links are used to broadcast at constant intervals, while direct links transmit messages only when packets are ready for transmission. FROST allows the user substantial flexibility to customize output for a simulation. Output consists of tables and graphs, as specified in the TCD file, to be generated at the specified interval. These tables may be generated at short intervals during the run to produce snapshots as simulation proceeds, or generated after the run to give a summary of the entire run. FROST is written in SIMSCRIPT II.5 (developed by CACI) for DEC VAX series computers running VMS. FROST was developed on a VAX 8700 and is intended to be run on large VAXes with at least 32Mb of memory. The main memory requirement for FROST is dependent on the number of processors used in the simulation and the event time. The standard distribution medium for this package is a 9-track 1600 BPI DEC VAX BACKUP Format Magnetic Tape. An executable is included on the tape in addition to the source code. FROST was developed in 1990 and is a copyrighted work with all copyright vested in NASA. DEC, VAX and VMS are registered trademarks of Digital Equipment Corporation. IBM PC is a trademark of International Business Machines. SIMSCRIPT II.5 is a trademark of CACI.

BUMPERII - DESIGN ANALYSIS CODE FOR OPTIMIZING SPACECRAFT SHIELDING AND WALL CONFIGURATION FOR ORBITAL DEBRIS AND METEOROID IMPACTS

NASA Technical Reports Server (NTRS)

Hill, S. A.

1994-01-01

BUMPERII is a modular program package employing a numerical solution technique to calculate a spacecraft's probability of no penetration (PNP) from man-made orbital debris or meteoroid impacts. The solution equation used to calculate the PNP is based on the Poisson distribution model for similar analysis of smaller craft, but reflects the more rigorous mathematical modeling of spacecraft geometry, orientation, and impact characteristics necessary for treatment of larger structures such as space station components. The technique considers the spacecraft surface in terms of a series of flat plate elements. It divides the threat environment into a number of finite cases, then evaluates each element of each threat. The code allows for impact shielding (shadowing) of one element by another in various configurations over the spacecraft exterior, and also allows for the effects of changing spacecraft flight orientation and attitude. Four main modules comprise the overall BUMPERII package: GEOMETRY, RESPONSE, SHIELD, and CONTOUR. The GEOMETRY module accepts user-generated finite element model (FEM) representations of the spacecraft geometry and creates geometry databases for both meteoroid and debris analysis. The GEOMETRY module expects input to be in either SUPERTAB Universal File Format or PATRAN Neutral File Format. The RESPONSE module creates wall penetration response databases, one for meteoroid analysis and one for debris analysis, for up to 100 unique wall configurations. This module also creates a file containing critical diameter as a function of impact velocity and impact angle for each wall configuration. The SHIELD module calculates the PNP for the modeled structure given exposure time, operating altitude, element ID ranges, and the data from the RESPONSE and GEOMETRY databases. The results appear in a summary file. SHIELD will also determine the effective area of the components and the overall model, and it can produce a data file containing the probability of penetration values per surface area for each element in the model. The SHIELD module writes this data file in either SUPERTAB Universal File Format or PATRAN Neutral File Format so threat contour plots can be generated as a post-processing feature of the FEM programs SUPERTAB and PATRAN. The CONTOUR module combines the functions of the RESPONSE module and most of the SHIELD module functions allowing determination of ranges of PNP's by looping over ranges of shield and/or wall thicknesses. A data file containing the PNP's for the corresponding shield and vessel wall thickness is produced. Users may perform sensitivity studies of two kinds. The effects of simple variations in orbital time, surface area, and flux may be analyzed by making changes to the terms in the equation representing the average number of penetrating particles per unit time in the PNP solution equation. The package analyzes other changes, including model environment, surface area, and configuration, by re-running the solution sequence with new GEOMETRY and RESPONSE data. BUMPERII can be run with no interactive output to the screen during execution. This can be particularly useful during batch runs. BUMPERII is written in FORTRAN 77 for DEC VAX series computers running under VMS, and was written for use with the finite-element model code SUPERTAB or PATRAN as both a pre-processor and a post-processor. Use of an alternate FEM code will require either development of a translator to change data format or modification of the GEOMETRY subroutine in BUMPERII. This program is available in DEC VAX BACKUP format on a 9-track 1600 BPI magnetic tape (standard distribution media) or on TK50 tape cartridge. The original BUMPER code was developed in 1988 with the BUMPERII revisions following in 1991 and 1992. SUPERTAB is a former name for I-DEAS. I-DEAS Finite Element Modeling is a trademark of Structural Dynamics Research Corporation. DEC, VAX, VMS and TK50 are trademarks of Digital Equipment Corporation.

HOLEGAGE 1.0 - STRAIN GAGE HOLE DRILLING ANALYSIS PROGRAM

NASA Technical Reports Server (NTRS)

Hampton, R. W.

1994-01-01

There is no simple and perfect way to measure residual stresses in metal parts that have been welded or deformed to make complex structures such as pressure vessels and aircraft, yet these locked-in stresses can contribute to structural failure by fatigue and fracture. However, one proven and tested technique for determining the internal stress of a metal part is to drill a test hole while measuring the relieved strains around the hole, such as the hole-drilling strain gage method described in ASTM E 837. The program HOLEGAGE processes strain gage data and provides additional calculations of internal stress variations that are not obtained with standard E 837 analysis methods. The typical application of the technique uses a three gage rosette with a special hole-drilling fixture for drilling a hole through the center of the rosette to produce a hole with very small gage pattern eccentricity error. Another device is used to control the drilling and halt the drill at controlled depth steps. At each step, strains from all three strain gages are recorded. The influence coefficients used by HOLEGAGE to compute stresses from relieved hole strains were developed by published finite element method studies of thick plates for specific hole sizes and depths. The program uses a parabolic fit and an interpolating scheme to project the coefficients to other hole sizes and depths. Additionally, published experimental data are used to extend the coefficients to relatively thin plates. These influence coefficients are used to compute the stresses in the original part from the strain data. HOLEGAGE will compute interior planar stresses using strain data from each drilled hole depth layer. Planar stresses may be computed in three ways including: a least squares fit for a linear variation with depth, an integral method to give incremental stress data for each layer, or by a linear fit to the integral data (with some surface data points omitted) to predict surface stresses before strain gage sanding preparations introduced additional residual stresses. Options are included for estimating the effect of hole eccentricity on calculations, smoothing noise from the strain data, and inputting the program data either interactively or from a data file. HOLEGAGE was written in FORTRAN 77 for DEC VAX computers under VMS, and is transportable except for system-unique TIME and DATE system calls. The program requires 54K of main memory and was developed in 1990. The program is available on a 9-track 1600 BPI VAX BACKUP format magnetic tape (standard media) or a TK50 tape cartridge. The documentation is included on the tape. DEC VAX and VMS are trademarks of Digital Equipment Corporation.

kgp, rgpA, and rgpB DNA vaccines induce antibody responses in experimental peri-implantitis.

PubMed

Guo, Meihua; Wang, Zhifeng; Fan, Xin; Bian, Yuanyuan; Wang, Tiantian; Zhu, Lina; Lan, Jing

2014-11-01

Peri-implantitis is the key factor for implant failure. This study aims to evaluate kgp, rgpA, and rgpB DNA vaccines to induce an immune response and prevent peri-implantitis. The kgp, rgpA, and rgpB genes were amplified by polymerase chain reaction (PCR) from Porphyromonas gingivalis (Pg) ATCC 33277 and cloned into the pVAX1 vector. Titanium implants were placed into the mandibular bone of dogs. Three months later, the animals were divided into four groups, immunized with pVAX1-kgp, pVAX1-rgpA, pVAX1-rgpB, or pVAX1. Cotton ligatures infiltrated with Pg were tied around the neck of the implants. Immunoglobulin (Ig)G and IgA antibodies were detected by enzyme-linked immunosorbent assay before and after immunization. The kgp, rgpA, and rgpB genes were successfully cloned into the pVAX1 plasmid. Animals immunized with pVAX1-kgp and pVAX1-rgpA showed higher titers of IgG and IgA antibodies compared to those before immunization (P <0.05) and compared to those that were immunized with pVAX1 and pVAX1-rgpB, whereas there were no significant differences in the animals treated with pVAX1 and pVAX1-rgpB. Furthermore, among these, the kgp DNA vaccine was more effective. The bone losses of the groups with pVAX1-kgp and pVAX1-rgpA were significantly attenuated. pVAX1-kgp and pVAX1-rgpA DNA vaccines enhanced immunity responses and significantly retarded bone loss in experimental peri-implantitis animal models, whereas pVAX1-rgpB was ineffective.

VaxView: Vaccination Coverage [data] in the U.S.

MedlinePlus

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Expedition 14 Crew and Backup Crew Training

NASA Image and Video Library

2006-05-24

JSC2006-E-20053 (24 May 2006) --- Astronaut Clayton C. Anderson, Expedition 14 backup flight engineer, participates in Journals experiment overview training in the Flight Operations Facility at Johnson Space Center. This type of training is a presentation format regarding the experiment objectives and tools. Training instructor Lindsay Kirschner assisted Anderson.

TAE+ 5.1 - TRANSPORTABLE APPLICATIONS ENVIRONMENT PLUS, VERSION 5.1 (DEC VAX ULTRIX VERSION)

NASA Technical Reports Server (NTRS)

TAE SUPPORT OFFICE

1994-01-01

TAE (Transportable Applications Environment) Plus is an integrated, portable environment for developing and running interactive window, text, and graphical object-based application systems. The program allows both programmers and non-programmers to easily construct their own custom application interface and to move that interface and application to different machine environments. TAE Plus makes both the application and the machine environment transparent, with noticeable improvements in the learning curve. The main components of TAE Plus are as follows: (1) the WorkBench, a What You See Is What You Get (WYSIWYG) tool for the design and layout of a user interface; (2) the Window Programming Tools Package (WPT), a set of callable subroutines that control an application's user interface; and (3) TAE Command Language (TCL), an easy-to-learn command language that provides an easy way to develop an executable application prototype with a run-time interpreted language. The WorkBench tool allows the application developer to interactively construct the layout of an application's display screen by manipulating a set of interaction objects including input items such as buttons, icons, and scrolling text lists. Data-driven graphical objects such as dials, thermometers, and strip charts are also included. TAE Plus updates the strip chart as the data values change. The WorkBench user specifies the windows and interaction objects that will make up the user interface, then specifies the sequence of the user interface dialogue. The description of the designed user interface is then saved into resource files. For those who desire to develop the designed user interface into an operational application, the WorkBench tool also generates source code (C, Ada, and TCL) which fully controls the application's user interface through function calls to the WPTs. The WPTs are the runtime services used by application programs to display and control the user interfaces. Since the WPTs access the workbench-generated resource files during each execution, details such as color, font, location, and object type remain independent from the application code, allowing changes to the user interface without recompiling and relinking. The Silicon Graphics version of TAE Plus now has a font caching scheme and a color caching scheme to make color allocation more efficient. In addition to WPTs, TAE Plus can control interaction of objects from the interpreted TAE Command Language. TCL provides an extremely powerful means for the more experienced developer to quickly prototype an application's use of TAE Plus interaction objects and add programming logic without the overhead of compiling or linking. TAE Plus requires MIT's X Window System, Version 11 Release 4, and the Open Software Foundation's Motif Toolkit 1.1 or 1.1.1. The Workbench and WPTs are written in C++ and the remaining code is written in C. TAE Plus is available by license for an unlimited time period. The licensed program product includes the TAE Plus source code and one set of supporting documentation. Additional documentation may be purchased separately at the price indicated below. The amount of disk space required to load the TAE Plus tar format tape is between 35Mb and 67Mb depending on the machine version. The recommended minimum memory is 12Mb. Each TAE Plus platform delivery tape includes pre-built libraries and executable binary code for that particular machine, as well as source code, so users do not have to do an installation. Users wishing to recompile the source will need both a C compiler and either GNU's C++ Version 1.39 or later, or a C++ compiler based on AT&T 2.0 cfront. TAE Plus comes with InterViews and idraw, two software packages developed by Stanford University and integrated in TAE Plus. TAE Plus was developed in 1989 and version 5.1 was released in 1991. TAE Plus is currently available on media suitable for eight different machine platforms: 1) DEC VAX computers running VMS 5.3 or higher (TK50 cartridge in VAX BACKUP format), 2) DEC VAXstations running ULTRIX 4.1 or later (TK50 cartridge in UNIX tar format), 3) DEC RISC workstations running ULTRIX 4.1 or later (TK50 cartridge in UNIX tar format), 4) HP9000 Series 300/400 computers running HP-UX 8.0 (.25 inch HP-preformatted tape cartridge in UNIX tar format), 5) HP9000 Series 700 computers running HP-UX 8.05 (HP 4mm DDS DAT tape cartridge in UNIX tar format), 6) Sun3 series computers running SunOS 4.1.1 (.25 inch tape cartridge in UNIX tar format), 7) Sun4 (SPARC) series computers running SunOS 4.1.1 (.25 inch tape cartridge in UNIX tar format), and 8) SGI Indigo computers running IRIX 4.0.1 and IRIX/Motif 1.0.1 (.25 inch IRIS tape cartridge in UNIX tar format). An optional Motif Object Code License is available for either Sun version. TAE is a trademark of the National Aeronautics and Space Administration. X Window System is a trademark of the Massachusetts Institute of Technology. Motif is a trademark of the Open Software Foundation. DEC, VAX, VMS, TK50 and ULTRIX are trademarks of Digital Equipment Corporation. HP9000 and HP-UX are trademarks of Hewlett-Packard Co. Sun3, Sun4, SunOS, and SPARC are trademarks of Sun Microsystems, Inc. SGI and IRIS are registered trademarks of Silicon Graphics, Inc.

The digital geologic map of Colorado in ARC/INFO format, Part A. Documentation

USGS Publications Warehouse

Green, Gregory N.

1992-01-01

This geologic map was prepared as a part of a study of digital methods and techniques as applied to complex geologic maps. The geologic map was digitized from the original scribe sheets used to prepare the published Geologic Map of Colorado (Tweto 1979). Consequently the digital version is at 1:500,000 scale using the Lambert Conformal Conic map projection parameters of the state base map. Stable base contact prints of the scribe sheets were scanned on a Tektronix 4991 digital scanner. The scanner automatically converts the scanned image to an ASCII vector format. These vectors were transferred to a VAX minicomputer, where they were then loaded into ARC/INFO. Each vector and polygon was given attributes derived from the original 1979 geologic map. This database was developed on a MicroVAX computer system using VAX V 5.4 nd ARC/INFO 5.0 software. UPDATE: April 1995, The update was done solely for the purpose of adding the abilitly to plot to an HP650c plotter. Two new ARC/INFO plot AMLs along with a lineset and shadeset for the HP650C design jet printer have been included. These new files are COLORADO.650, INDEX.650, TWETOLIN.E00 and TWETOSHD.E00. These files were created on a UNIX platform with ARC/INFO 6.1.2. Updated versions of INDEX.E00, CONTACT.E00, LINE.E00, DECO.E00 and BORDER.E00 files that included the newly defined HP650c items are also included. * Any use of trade, product, or firm names is for descriptive purposes only and does not imply endorsement by the U.S. Government. Descriptors: The Digital Geologic Map of Colorado in ARC/INFO Format Open-File Report 92-050

The digital geologic map of Colorado in ARC/INFO format, Part B. Common files

USGS Publications Warehouse

Green, Gregory N.

1992-01-01

This geologic map was prepared as a part of a study of digital methods and techniques as applied to complex geologic maps. The geologic map was digitized from the original scribe sheets used to prepare the published Geologic Map of Colorado (Tweto 1979). Consequently the digital version is at 1:500,000 scale using the Lambert Conformal Conic map projection parameters of the state base map. Stable base contact prints of the scribe sheets were scanned on a Tektronix 4991 digital scanner. The scanner automatically converts the scanned image to an ASCII vector format. These vectors were transferred to a VAX minicomputer, where they were then loaded into ARC/INFO. Each vector and polygon was given attributes derived from the original 1979 geologic map. This database was developed on a MicroVAX computer system using VAX V 5.4 nd ARC/INFO 5.0 software. UPDATE: April 1995, The update was done solely for the purpose of adding the abilitly to plot to an HP650c plotter. Two new ARC/INFO plot AMLs along with a lineset and shadeset for the HP650C design jet printer have been included. These new files are COLORADO.650, INDEX.650, TWETOLIN.E00 and TWETOSHD.E00. These files were created on a UNIX platform with ARC/INFO 6.1.2. Updated versions of INDEX.E00, CONTACT.E00, LINE.E00, DECO.E00 and BORDER.E00 files that included the newly defined HP650c items are also included. * Any use of trade, product, or firm names is for descriptive purposes only and does not imply endorsement by the U.S. Government. Descriptors: The Digital Geologic Map of Colorado in ARC/INFO Format Open-File Report 92-050

NJE; VAX-VMS IBM NJE network protocol emulator. [DEC VAX11/780; VAX-11 FORTRAN 77 (99%) and MACRO-11 (1%)

DOE Office of Scientific and Technical Information (OSTI.GOV)

Engert, D.E.; Raffenetti, C.

NJE is communications software developed to enable a VAX VMS system to participate as an end-node in a standard IBM network by emulating the Network Job Entry (NJE) protocol. NJE supports job networking for the operating systems used on most large IBM-compatible computers (e.g., VM/370, MVS with JES2 or JES3, SVS, MVT with ASP or HASP). Files received by the VAX can be printed or saved in user-selected disk files. Files sent to the network can be routed to any network node for printing, punching, or job submission, or to a VM/370 user's virtual reader. Files sent from the VAXmore » are queued and transmitted asynchronously. No changes are required to the IBM software.DEC VAX11/780; VAX-11 FORTRAN 77 (99%) and MACRO-11 (1%); VMS 2.5; VAX11/780 with DUP-11 UNIBUS interface and 9600 baud synchronous modem..« less

Efficacy of chimeric DNA vaccines encoding Eimeria tenella 5401 and chicken IFN-γ or IL-2 against coccidiosis in chickens.

PubMed

Song, Xiaokai; Huang, Xinmei; Yan, Ruofeng; Xu, Lixin; Li, Xiangrui

2015-09-01

Chimeric DNA vaccines encoding Eimeria tenella (E. tenella) surface antigen 5401 were constructed and their efficacies against E. tenella challenge were studied. The open reading frame (ORF) of 5401 was cloned into the prokaryotic expression vector pGEX-4T2 to express the recombinant protein and the expressed recombinant protein was identified by Western blot. The ORF of 5401 and chicken cytokine gene IFN-γ or IL-2 were cloned into the eukaryotic expression vector pVAX1 consecutively to construct DNA vaccines pVAX-5401-IFN-γ, pVAX-5401-IL-2 and pVAX-5401. The expression of aim genes in vivo was detected by reverse transcription-polymerase chain reaction and Western blot. Fourteen-day-old chickens were inoculated twice at an interval of 7 days with 100 µg of plasmids pVAX-5401, pVAX-5401-IFN-γ and pVAX-5401-IL-2 or 200 µg of recombinant 5401 protein by leg intramuscular injection, respectively. Seven days after the second inoculation, all chickens except the unchallenged control group were challenged orally with 5 × 10(4) sporulated oocysts of E. tenella. Seven days after challenge, all chickens were weighted and slaughtered to determine the effects of immunization. The results showed the recombinant protein was about 90 kDa and reacted with antiserum against soluble sporozoites. The animal experiment showed that all the DNA vaccines pVAX-5401, pVAX-5401-IFN-γ or pVAX-5401-IL-2 and the recombinant 5401 protein could obviously alleviate body weight loss and cecal lesions as compared with non-vaccinated challenged control and empty vector pVAX1control. Furthermore, pVAX-5401-IFN-γ or pVAX-5401-IL-2 induced anti-coccidial index (ACI) of 180.01 or 177.24 which were significantly higher than that of pVAX-5401. The results suggested that 5401 was an effective candidate antigen for vaccine. This finding also suggested that chicken IFN-γ or IL-2 could effectively improve the efficacies of DNA vaccines against avian coccidiosis. Copyright © 2015 Elsevier Inc. All rights reserved.

Immune responses of mice immunized by DNA plasmids encoding PCV2 ORF 2 gene, porcine IL-15 or the both.

PubMed

Dong, Bo; Feng, Jing; Lin, Hai; Li, Lanxiang; Su, Dingding; Tu, Di; Zhu, Weijuan; Yang, Qing; Ren, Xiaofeng

2013-11-19

Porcine circovirus type 2 (PCV2) is associated with many kinds of diseases including postweaning multisystemic wasting syndrome (PMWS). It affects the immune system of swine and causes huge epidemic losses every year. In our previous study, we provided evidence that DNA plasmid bearing porcine IL-15 (pVAX-pIL-15) might serve as an immune enhancer for DNA plasmid encoding porcine reproductive and respiratory syndrome virus GP5 gene. In this study, PCV2 open reading frame (ORF)2 gene was cloned into the eukaryotic expression vector pVAX, resulting in the plasmid pVAX-PCV2-ORF2. Transient expression of the plasmid in BHK-21 cells could be detected using immunofluorescence assay. Experimental mice were divided into 5 groups and immunized with PBS, pVAX, pVAX-pIL-15, pVAX-PCV2-ORF2 or pVAX-pIL-15 plus pVAX-PCV2-ORF2. The results showed that the mice co-inoculated with pVAX-PCV2-ORF2 plus pVAX-pIL-15 had higher humoral and cellular immune responses than the others. In addition, DNA plasmid bearing PCV2 ORF2 gene had a protective effect against challenge with PCV2 in mice which could be promoted with the utilization of pIL-15. Copyright © 2013 Elsevier Ltd. All rights reserved.

Alternative end-joining repair pathways are the ultimate backup for abrogated classical non-homologous end-joining and homologous recombination repair: Implications for the formation of chromosome translocations.

PubMed

Iliakis, George; Murmann, Tamara; Soni, Aashish

2015-11-01

DNA double strand breaks (DSB) are the most deleterious lesions for the integrity of the genome, as their misrepair can lead to the formation of chromosome translocations. Cells have evolved two main repair pathways to suppress the formation of these genotoxic lesions: homology-dependent, error-free homologous recombination repair (HRR), and potentially error-prone, classical, DNA-PK-dependent non-homologous end-joining (c-NHEJ). The most salient feature of c-NHEJ, speed, will largely suppress chromosome translocation formation, while sequence alterations at the junction remain possible. It is now widely accepted that when c-NHEJ is inactivated, globally or locally, an alternative form of end-joining (alt-EJ) removes DSBs. Alt-EJ operates with speed and fidelity markedly lower than c-NHEJ, causing thus with higher probability chromosome translocations, and generating more extensive sequence alterations at the junction. Our working hypothesis is that alt-EJ operates as a backup to c-NHEJ. Recent results show that alt-EJ can also backup abrogated HRR in G2 phase cells, again at the cost of elevated formation of chromosome translocations. These observations raise alt-EJ to a global rescuing mechanism operating on ends that have lost their chromatin context in ways that compromise processing by HRR or c-NHEJ. While responsible for eliminating from the genome highly cytotoxic DNA ends, alt-EJ provides this function at the price of increased translocation formation. Here, we analyze recent literature on the mechanisms of chromosome translocation formation and propose a functional hierarchy among DSB processing pathways that makes alt-EJ the global backup pathway. We discuss possible ramifications of this model in cellular DSB management and pathway choice, and analyze its implications in radiation carcinogenesis and the design of novel therapeutic approaches. Copyright © 2015 Elsevier B.V. All rights reserved.

MultiNet TCP/P/IP for VAX/VMS update

NASA Technical Reports Server (NTRS)

Vance, L. Stuart

1991-01-01

Outlines of device support; DECnet interoperability; installation; MultiNet services; domain name server; Telnet; FTP; SMTP; DECwindows over TCP/IP; BSD r services; remote printing; RPC services and NFS server; NFS client; netcontrol; diagnostics; programming support; and MultiNet features are presented in viewgraph format.

TAE+ 5.1 - TRANSPORTABLE APPLICATIONS ENVIRONMENT PLUS, VERSION 5.1 (VAX VMS VERSION)

NASA Technical Reports Server (NTRS)

TAE SUPPORT OFFICE

1994-01-01

TAE (Transportable Applications Environment) Plus is an integrated, portable environment for developing and running interactive window, text, and graphical object-based application systems. The program allows both programmers and non-programmers to easily construct their own custom application interface and to move that interface and application to different machine environments. TAE Plus makes both the application and the machine environment transparent, with noticeable improvements in the learning curve. The main components of TAE Plus are as follows: (1) the WorkBench, a What You See Is What You Get (WYSIWYG) tool for the design and layout of a user interface; (2) the Window Programming Tools Package (WPT), a set of callable subroutines that control an application's user interface; and (3) TAE Command Language (TCL), an easy-to-learn command language that provides an easy way to develop an executable application prototype with a run-time interpreted language. The WorkBench tool allows the application developer to interactively construct the layout of an application's display screen by manipulating a set of interaction objects including input items such as buttons, icons, and scrolling text lists. User interface interactive objects include data-driven graphical objects such as dials, thermometers, and strip charts as well as menubars, option menus, file selection items, message items, push buttons, and color loggers. The WorkBench user specifies the windows and interaction objects that will make up the user interface, then specifies the sequence of the user interface dialogue. The description of the designed user interface is then saved into resource files. For those who desire to develop the designed user interface into an operational application, the WorkBench tool also generates source code (C, C++, Ada, and TCL) which fully controls the application's user interface through function calls to the WPTs. The WPTs are the runtime services used by application programs to display and control the user interfaces. Since the WPTs access the workbench-generated resource files during each execution, details such as color, font, location, and object type remain independent from the application code, allowing changes to the user interface without recompiling and relinking. In addition to WPTs, TAE Plus can control interaction of objects from the interpreted TAE Command Language. TCL provides a means for the more experienced developer to quickly prototype an application's use of TAE Plus interaction objects and add programming logic without the overhead of compiling or linking. TAE Plus requires MIT's X Window System, Version 11 Release 4, and the Open Software Foundation's Motif. The Workbench and WPTs are written in C++ and the remaining code is written in C. TAE Plus is available by license for an unlimited time period. The licensed program product includes the TAE Plus source code and one set of supporting documentation. Additional documentation may be purchased separately at the price indicated below. The amount of disk space required to load the TAE Plus tar format tape is between 35Mb and 67Mb depending on the machine version. The recommended minimum memory is 12Mb. Each TAE Plus platform delivery tape includes pre-built libraries and executable binary code for that particular machine, as well as source code, so users do not have to do an installation. Users wishing to recompile the source will need both a C compiler and either GNU's C++ Version 1.39 or later, or a C++ compiler based on AT&T 2.0 cfront. TAE Plus was developed in 1989 and version 5.2 was released in 1993. TAE Plus 5.2 is expected to be available on media suitable for seven different machine platforms: 1) DEC VAX computers running VMS (TK50 cartridge in VAX BACKUP format), 2) IBM RS/6000 series workstations running AIX (.25 inch tape cartridge in UNIX tar format), 3) DEC RISC workstations running ULTRIX (TK50 cartridge in UNIX tar format), 4) HP9000 Series 300/400 computers running HP-UX (.25 inch HP-preformatted tape cartridge in UNIX tar format), 5) HP9000 Series 700 computers running HP-UX (HP 4mm DDS DAT tape cartridge in UNIX tar format), 6) Sun4 (SPARC) series computers running SunOS (.25 inch tape cartridge in UNIX tar format), and 7) SGI Indigo computers running IRIX (.25 inch IRIS tape cartridge in UNIX tar format). Please contact COSMIC to obtain detailed information about the supported operating system and OSF/Motif releases required for each of these machine versions. An optional Motif Object Code License is available for the Sun4 version of TAE Plus 5.2.

User's manual for the VAX-Gerber link software package. Revision 1. 0

DOE Office of Scientific and Technical Information (OSTI.GOV)

Isobe, G.W.

1985-10-01

This manual provides a user the information necessary to run the VAX-Gerber link software package. It is expected that the user already knows how to login to the VAX, and is familiar with the Gerber Photo Plotter. It is also highly desirable that the user be familiar with the full screen editor on the VAX, EDT.

Analytic Patch Configuration (APC) gateway version 1.0 user's guide

NASA Technical Reports Server (NTRS)

Bingel, Bradford D.

1990-01-01

The Analytic Patch Configuration (APC) is an interactive software tool which translates aircraft configuration geometry files from one format into another. This initial release of the APC Gateway accommodates six formats: the four accepted APC formats (89f, 89fd, 89u, and 89ud), the PATRAN 2.x phase 1 neutral file format, and the Integrated Aerodynamic Analysis System (IAAS) General Geometry (GG) format. Written in ANSI FORTRAN 77 and completely self-contained, the APC Gateway is very portable and was already installed on CDC/NOS, VAX/VMS, SUN, SGI/IRIS, CONVEX, and GRAY hosts.

Advanced Transport Operating System (ATOPS) color displays software description: MicroVAX system

NASA Technical Reports Server (NTRS)

Slominski, Christopher J.; Plyler, Valerie E.; Dickson, Richard W.

1992-01-01

This document describes the software created for the Display MicroVAX computer used for the Advanced Transport Operating Systems (ATOPS) project on the Transport Systems Research Vehicle (TSRV). The software delivery of February 27, 1991, known as the 'baseline display system', is the one described in this document. Throughout this publication, module descriptions are presented in a standardized format which contains module purpose, calling sequence, detailed description, and global references. The global references section includes subroutines, functions, and common variables referenced by a particular module. The system described supports the Research Flight Deck (RFD) of the TSRV. The RFD contains eight Cathode Ray Tubes (CRTs) which depict a Primary Flight Display, Navigation Display, System Warning Display, Takeoff Performance Monitoring System Display, and Engine Display.

Clustering and Installing Satellite Nodes

NASA Astrophysics Data System (ADS)

Lotts, A. P.

This note describes basic clustering and the installation of a MicroVax or VaxStation as a Satellite node of an LAVC (Local Area VaxCluster). It will NOT describe Dual Porting of a MicroVax. It assumes that VMS 4.6 is running on the Boot node, that the LAVC key has been applied and that BOOT_CONFIG has been run as described in the LAVC manual.

An all-FORTRAN version of NASTRAN for the VAX

NASA Technical Reports Server (NTRS)

Purves, L.

1981-01-01

All FORTRAN version of NASA structural analysis program NASATRAN is implemented on DEC VAX-series computer. Applications of NASATRAN extend to almost every type of linear structure and construction. Two special features are available in VAX version; program is executed from terminal in manner permitting use of VAX interactive debugger, and links are interactively restarted when desired by first making copy of all NASATRAN work files.

Metal/Ceramic Interfaces: Relationships Between Structure and Chemistry

DTIC Science & Technology

1992-12-31

using an Eikonix camera linked to the Vax Station 3200. § 3. RESULTS AND DISCUSSION In this section, results are reported and discussed for four aspects... GESELLS ( HA ~FU ~(R NIET’ALLK1 DE EN. ~ DR. RIEDERER-VERLAG GMBH POSTFACH 104052 7000 STUTTGART I Bd. 81 (1990) H 10 Spinel Interphase Formation at NU

Security Package for the VAX

NASA Technical Reports Server (NTRS)

Marks, V. J.; Benigue, C. E.

1983-01-01

Four programs deal with intruders and resource managment. Package available from COSMIC provides DEC VAX-11/780 with certain "deterent" security features. Although packages is not comprehensive security system, of interest for any VAX installation where security is concern.

Ada Compiler Validation Summary Report: Certificate Number: 940305W1. 11335 TLD Systems, Ltd. TLD Comanche VAX/i960 Ada Compiler System, Version 4.1.1 VAX Cluster under VMS 5.5 = Tronix JIAWG Execution Vehicle (i960MX) under TLD Real Time Executive, Version 4.1.1

DTIC Science & Technology

1994-03-14

Comanche VAX/i960 Ada Compiler System, Version 4.1.1 Host Computer System: Digital Local Area Network VAX Cluster executing on (2) MicroVAX 3100 Model 90...31 $MAX DIGITS 15 SmNx INT 2147483647 $MAX INT PLUS_1 2147483648 $MIN IN -2_147483648 A-3 MACR PARAMEERIS $NAME NO SUCH INTEGER TYPE $NAME LIST...nested generlcs are Supported and generics defined in libary units are pexitted. zt is not possible to pen ore a macro instantiation for a generic I

A small population of hypothalamic neurons govern fertility: the critical role of VAX1 in GnRH neuron development and fertility maintenance.

PubMed

Hoffmann, Hanne M; Mellon, Pamela L

2016-01-01

Fertility depends on the correct maturation and function of approximately 800 gonadotropin-releasing hormone (GnRH) neurons in the brain. GnRH neurons are at the apex of the hypothalamic-pituitary-gonadal axis that regulates fertility. In adulthood, GnRH neurons are scattered throughout the anterior hypothalamic area and project to the median eminence, where GnRH is released into the portal vasculature to stimulate release of luteinizing hormone (LH) and follicle-stimulating hormone (FSH) from the pituitary. LH and FSH then regulate gonadal steroidogenesis and gametogenesis. Absence of GnRH neurons or inappropriate GnRH release leads to infertility. Despite the critical role of GnRH neurons in fertility, we still have a limited understanding of the genes responsible for proper GnRH neuron development and function in adulthood. GnRH neurons originate in the olfactory placode then migrate into the brain. Homeodomain transcription factors expressed within GnRH neurons or along their migratory path are candidate genes for inherited infertility. Using a combined in vitro and in vivo approach, we have identified Ventral Anterior Homeobox 1 ( Vax1 ) as a novel homeodomain transcription factor responsible for GnRH neuron maturation and fertility. GnRH neuron counts in Vax1 knock-out embryos revealed Vax1 to be required for the presence of GnRH-expressing cells at embryonic day 17.5 (E17.5), but not at E13.5. To localize the effects of Vax1 on fertility, we generated Vax1 flox mice and crossed them with Gnrh cre mice to specifically delete Vax1 within GnRH neurons. GnRH staining in Vax1 flox/flox :GnRH cre mice show a total absence of GnRH expression in the adult. We performed lineage tracing in Vax1 flox/flox :GnRH cre :RosaLacZ mice which proved GnRH neurons to be alive, but incapable of expressing GnRH. The absence of GnRH leads to delayed puberty, hypogonadism and complete infertility in both sexes. Finally, using the immortalized model GnRH neuron cell lines, GN11 and GT1-7, we show that VAX1 is a direct regulator of Gnrh1 transcription by binding key ATTA sites within the Gnrh1 promoter. This study identifies VAX1 as a key transcription factor regulating GnRH expression and establishes VAX1 as a novel candidate gene implicated in heritable infertility.

Melanoma Vaccine--AVAX Technologies: DNP-VACC, M-Vax.

PubMed

2003-01-01

Adis CommentsAVAX Technologies is developing a therapeutic melanoma vaccine [M-Vax, DNP-VACC] consisting of autologous tumour cells conjugated to a highly immunogenic hapten, dinitrophenyl, which makes the cancer cells more easily recognised by the immune system. AVAX licensed the autologous cell vaccine technology (AC Vaccine) from Thomas Jefferson University in Philadelphia, USA, where it was originally developed. M-Vax was launched in Australia in the first half of 2000, but was withdrawn from this market in September 2002 due to financial constraints faced by the company and its need to focus its resources on initiatives that provide the greatest return. Although AVAX applied for Federal Government price reimbursement in Australia through the Medical Services Advisory Committee during 2001, the vaccine is not reimbursed in Australia. Obtaining Federal Government reimbursement was a step AVAX considered essential for the success of the M-Vax. AVAX has not ruled out re-entering the Australian market again at a later date. AVAX will now concentrate on gaining approval in the US and Europe. M-Vax has received orphan drug designation from the US FDA. M-Vax is in preregistration in Germany, Japan and The Netherlands for treatment of stage III melanoma. In September 1999, the company announced that it expected to market M-Vax for treatment of stage III melanoma in Germany, Japan and the Netherlands. This announcement came after AVAX's continuing dialogue with senior regulatory authorities in several pharmaceutical markets. The commercial availability of M-Vax in Germany, Japan and The Netherlands will be subject to meeting certain requirements specified by the regulatory agency in each country. Phase II data have been submitted for regulatory approval in these countries; phase III data may not be required because the vaccine contains autologous tumour cells. This was the case with the Australian approval of M-Vax, which was on the basis of data from phase II trials. Clinical development: M-Vax was in a pivotal phase III trial for treatment of stage III melanoma in the US, and a multicentre phase II trial in the US for treatment of patients with stage IV melanoma with lung metastases. However, in late March 2001, AVAX announced that the FDA had suspended these trials until the agency had further reviewed them. Subsequently, AVAX received written communication from the FDA indicating that the suspension is related to manufacturing issues. These events triggered the resignations of AVAX's executive Vice-President and Vice-President of operations, at the request of the company's board of directors. AVAX met with the FDA in October 2001 to discuss the clinical holds on M-Vax and O-Vax. AVAX's proposed improvements involving a frozen vaccine were also discussed at the meeting. Following the meeting AVAX was told by the FDA that selected characterisation work would have to be carried out on the new products, and new INDs submitted. In December 2001 AVAX announced that the development of a frozen vaccine and changes to various policies and procedures would ensure that the company complied with the FDA regulations. A new IND was submitted to the FDA for M-Vax in September 2002. In August 2002, AVAX had been unsure whether following approval of its new IND it would re-initiate clinical development for both M-Vax and O-Vax in parallel, or advance one of the agents and wait for further funding for the other. However, in September it indicated that clinical trials of both vaccines would be conducted following approval of the IND. A total of 42 patients are to be enrolled in each trial. In October 2002, AVAX announced that the US FDA had no outstanding issues regarding the IND. AVAX can now proceed with clinical trials as planned. AVAX Technologies was enrolling patients with stage III melanoma in the pivotal US phase III trial for registration of M-Vax trade ed, multicentre trial designed to compare the efficacy of the vaccine against high-dose interferon-alpha, the standard post-surgical treatment for stage III melanoma. The two end-points are rate of melanoma tumour recurrence and overall survival. The dosing regimen chosen for this study is that which was found from several clinical studies to be most effective at eliciting a positive delayed-type hypersensitivity skin response to autologous melanoma cells. The study was being conducted at more than 20 US sites. A low dose of M-Vax was also being evaluated in a phase II study at Thomas Jefferson University in the US. On 16 March 2000, AVAX announced promising interim results from this study, which revealed that 65% of 23 evaluated patients developed an immune response of the same magnitude as that observed with higher doses of M-Vax in previous studies. The study was to enroll a total of 46 patients, who were to receive seven doses of M-Vax over 7 weeks. The advantage of using a low dose of M-Vax is that it requires a smaller amount of the patient's tumour tissue to produce the vaccine (approximately half that required in previous studies) and therefore more patients would be eligible for treatment. On the basis of these results, AVAX modified the pivotal phase III trial to use the low dose of M-Vax to treat additional patients with smaller tumours. On 29 March 2000, AVAX announced that it had initiated a multicentre phase II study in the US in patients with stage IV melanoma and lung metastases. Patients were receiving seven doses of M-Vax at weekly intervals and a booster at 6 months. AVAX initiated the study because of promising results in a study of stage IV melanoma patients with lung metastases in which patients treated with M-Vax had tumour regression and prolonged survival. Commercial agreements: In June 1999, AVAX announced its first international commercialisation opportunity for M-Vax, in Australia, where the company subsequently launched the vaccine (now withdrawn) in the first half of 2000. AVAX formed a subsidiary, AVAX Australia, which was co-marketing M-Vax in Australia together with Australian Vaccine Technologies (formerly Neptunus International Holdings). Under the terms of this agreement, Australian Vaccine Technologies purchased dollars A10 million in shares, a 50% interest, in AVAX Australia. The final dollars A3 million installment was made in August 2000. AVAX had an option to purchase up to 5% of shares in Australian Vaccine Technologies. In August 2002, AVAX extended and expanded an existing production agreement with Medigene for approximately 1 year. Under the terms of the agreement, Genopoietic (Medigene) in France will process clinical samples of M-Vax. In October 2002, AVAX signed a distribution agreement with Ferrer International, SA (Grupo Ferrer) for sales and distribution of the AC Vaccines, including M-Vax and O-Vax. The agreement covers Europe, Latin America and certain Asian territories. Under the terms of the agreement AVAX will retain manufacturing rights and will sell the vaccine to Ferrer. In return, Ferrer will make payments to AVAX for the product as well as certain milestone payments for marketing and registration goals. M-Vax was manufactured in Australia by Bioenterprises, a subsidiary of Biotech Australia. However, in 2002, the manufacturer underwent an acquisition with significant changes, which resulted in its decision to discontinue manufacturing M-Vax.

Requirement for Parp-1 and DNA ligases 1 or 3 but not of Xrcc1 in chromosomal translocation formation by backup end joining

PubMed Central

Soni, Aashish; Siemann, Maria; Grabos, Martha; Murmann, Tamara; Pantelias, Gabriel E.; Iliakis, George

2014-01-01

In mammalian cells, ionizing radiation (IR)-induced DNA double-strand breaks (DSBs) are repaired in all phases of the cell cycle predominantly by classical, DNA-PK-dependent nonhomologous end joining (D-NHEJ). Homologous recombination repair (HRR) is functional during the S- and G2-phases, when a sister chromatid becomes available. An error-prone, alternative form of end joining, operating as backup (B-NHEJ) functions robustly throughout the cell cycle and particularly in the G2-phase and is thought to backup predominantly D-NHEJ. Parp-1, DNA-ligases 1 (Lig1) and 3 (Lig3), and Xrcc1 are implicated in B-NHEJ. Chromosome and chromatid translocations are manifestations of erroneous DSB repair and are crucial culprits in malignant transformation and IR-induced cell lethality. We analyzed shifts in translocation formation deriving from defects in D-NHEJ or HRR in cells irradiated in the G2-phase and identify B-NHEJ as the main DSB repair pathway backing up both of these defects at the cost of a large increase in translocation formation. Our results identify Parp-1 and Lig1 and 3 as factors involved in translocation formation and show that Xrcc1 reinforces the function of Lig3 in the process without being required for it. Finally, we demonstrate intriguing connections between B-NHEJ and DNA end resection in translocation formation and show that, as for D-NHEJ and HRR, the function of B-NHEJ facilitates the recovery from the G2-checkpoint. These observations advance our understanding of chromosome aberration formation and have implications for the mechanism of action of Parp inhibitors. PMID:24748665

Requirement for Parp-1 and DNA ligases 1 or 3 but not of Xrcc1 in chromosomal translocation formation by backup end joining.

PubMed

Soni, Aashish; Siemann, Maria; Grabos, Martha; Murmann, Tamara; Pantelias, Gabriel E; Iliakis, George

2014-06-01

In mammalian cells, ionizing radiation (IR)-induced DNA double-strand breaks (DSBs) are repaired in all phases of the cell cycle predominantly by classical, DNA-PK-dependent nonhomologous end joining (D-NHEJ). Homologous recombination repair (HRR) is functional during the S- and G2-phases, when a sister chromatid becomes available. An error-prone, alternative form of end joining, operating as backup (B-NHEJ) functions robustly throughout the cell cycle and particularly in the G2-phase and is thought to backup predominantly D-NHEJ. Parp-1, DNA-ligases 1 (Lig1) and 3 (Lig3), and Xrcc1 are implicated in B-NHEJ. Chromosome and chromatid translocations are manifestations of erroneous DSB repair and are crucial culprits in malignant transformation and IR-induced cell lethality. We analyzed shifts in translocation formation deriving from defects in D-NHEJ or HRR in cells irradiated in the G2-phase and identify B-NHEJ as the main DSB repair pathway backing up both of these defects at the cost of a large increase in translocation formation. Our results identify Parp-1 and Lig1 and 3 as factors involved in translocation formation and show that Xrcc1 reinforces the function of Lig3 in the process without being required for it. Finally, we demonstrate intriguing connections between B-NHEJ and DNA end resection in translocation formation and show that, as for D-NHEJ and HRR, the function of B-NHEJ facilitates the recovery from the G2-checkpoint. These observations advance our understanding of chromosome aberration formation and have implications for the mechanism of action of Parp inhibitors. © The Author(s) 2014. Published by Oxford University Press on behalf of Nucleic Acids Research.

Protective efficacy of a Toxoplasma gondii rhoptry protein 13 plasmid DNA vaccine in mice.

PubMed

Wang, Pei-Yuan; Yuan, Zi-Guo; Petersen, Eskild; Li, Jie; Zhang, Xiu-Xiang; Li, Xiu-Zhen; Li, Hao-Xin; Lv, Zhi-Cheng; Cheng, Tian; Ren, Di; Yang, Gui-Lian; Lin, Rui-Qing; Zhu, Xing-Quan

2012-12-01

Toxoplasma gondii is an obligate intracellular parasite infecting humans and other warm-blooded animals, resulting in serious public health problems and economic losses worldwide. Rhoptries are involved in T. gondii invasion and host cell interaction and have been implicated as important virulence factors. In the present study, a DNA vaccine expressing rhoptry protein 13 (ROP13) of T. gondii inserted into eukaryotic expression vector pVAX I was constructed, and the immune protection it induced in Kunming mice was evaluated. Kunming mice were immunized intramuscularly with pVAX-ROP13 and/or with interleukin-18 (IL-18). Then, we evaluated the immune response using a lymphoproliferative assay, cytokine and antibody measurements, and the survival times of mice challenged with the virulent T. gondii RH strain (type I) and the cyst-forming PRU strain (type II). The results showed that pVAX-ROP13 alone or with pVAX/IL-18 induced a high level of specific anti-T. gondii antibodies and specific lymphocyte proliferative responses. Coinjection of pVAX/IL-18 significantly increased the production of gamma interferon (IFN-γ), IL-2, IL-4, and IL-10. Further, challenge experiments showed that coimmunization of pVAX-ROP13 with pVAX/IL-18 significantly (P < 0.05) increased survival time (32.3 ± 2.7 days) compared with pVAX-ROP13 alone (24.9 ± 2.3 days). Immunized mice challenged with T. gondii cysts (strain PRU) had a significant reduction in the number of brain cysts, suggesting that ROP13 could trigger a strong humoral and cellular response against T. gondii cyst infection and that it is a potential vaccine candidate against toxoplasmosis, which provided the foundation for further development of effective vaccines against T. gondii.

iVAX: An integrated toolkit for the selection and optimization of antigens and the design of epitope-driven vaccines.

PubMed

Moise, Leonard; Gutierrez, Andres; Kibria, Farzana; Martin, Rebecca; Tassone, Ryan; Liu, Rui; Terry, Frances; Martin, Bill; De Groot, Anne S

2015-01-01

Computational vaccine design, also known as computational vaccinology, encompasses epitope mapping, antigen selection and immunogen design using computational tools. The iVAX toolkit is an integrated set of tools that has been in development since 1998 by De Groot and Martin. It comprises a suite of immunoinformatics algorithms for triaging candidate antigens, selecting immunogenic and conserved T cell epitopes, eliminating regulatory T cell epitopes, and optimizing antigens for immunogenicity and protection against disease. iVAX has been applied to vaccine development programs for emerging infectious diseases, cancer antigens and biodefense targets. Several iVAX vaccine design projects have had success in pre-clinical studies in animal models and are progressing toward clinical studies. The toolkit now incorporates a range of immunoinformatics tools for infectious disease and cancer immunotherapy vaccine design. This article will provide a guide to the iVAX approach to computational vaccinology.

ReadyVax: A new mobile vaccine information app.

PubMed

Bednarczyk, Robert A; Frew, Paula M; Salmon, Daniel A; Whitney, Ellen; Omer, Saad B

2017-05-04

Vaccine information of varying quality is available through many different sources. We describe the creation, release and utilization of ReadyVax, a new mobile smartphone app providing access to trustworthy, evidence-based vaccine information for a target audience of healthcare providers, pharmacists, and patients (including parents of children). We describe the information content and technical development of ReadyVax. Between the hard launch of the app on February 12, 2015 and October 8, 2016, the app has been downloaded by 5,142 unique users, with 6,841 total app sessions initiated, comprising a total of 15,491 screen views (2.3 screens/session on average). ReadyVax has been downloaded by users in 102 different countries; most users (52%) are from the United States. We are continuing outreach efforts to increase app use, and planning for development of an Android-compatible version of ReadyVax, to increase the available market for the app.

Enhancement of immunogenic response and protection in model rats by CSTM nanoparticles anticaries DNA vaccine.

PubMed

Li, Hongjiao; Lu, Yiming; Xiang, Jingjie; Jiang, Hailong; Zhong, Yanqiang; Lu, Ying

2016-06-01

To construct anticaries DNA vaccine and evaluate its ability to elicit mucosal and systemic immune responses in rats. wapA fragment was cloned into pVAX1 plasmid to generate pVAX1-wapA. The pVAX1-wapA/trimethyl chitosan nanoparticles were prepared by complex coacervation method. Significantly higher specific IgG antibody titers were observed in rats immunized with nanoparticles compared with rats immunized with naked pVAX1-wapA. Anti-WapA IgA and IgG antibody levels after intranasal immunization were significantly higher than those following intramuscular delivery of nanoparticles or naked pVAX1-wapA. Furthermore, fewer enamel, slight dentin and dentin moderate lesions were observed in rats immunized with nanoparticles. The results implicate WapA as an excellent candidate for anticaries vaccine development and nanoparticles as an effective delivery system.

ReadyVax: A new mobile vaccine information app

PubMed Central

Bednarczyk, Robert A.; Frew, Paula M.; Salmon, Daniel A.; Whitney, Ellen; Omer, Saad B.

2017-01-01

Abstract Vaccine information of varying quality is available through many different sources. We describe the creation, release and utilization of ReadyVax, a new mobile smartphone app providing access to trustworthy, evidence-based vaccine information for a target audience of healthcare providers, pharmacists, and patients (including parents of children). We describe the information content and technical development of ReadyVax. Between the hard launch of the app on February 12, 2015 and October 8, 2016, the app has been downloaded by 5,142 unique users, with 6,841 total app sessions initiated, comprising a total of 15,491 screen views (2.3 screens/session on average). ReadyVax has been downloaded by users in 102 different countries; most users (52%) are from the United States. We are continuing outreach efforts to increase app use, and planning for development of an Android-compatible version of ReadyVax, to increase the available market for the app. PMID:28059610

Program Converts VAX Floating-Point Data To UNIX

NASA Technical Reports Server (NTRS)

Alves, Marcos; Chapman, Bruce; Chu, Eugene

1996-01-01

VAX Floating Point to Host Floating Point Conversion (VAXFC) software converts non-ASCII files to unformatted floating-point representation of UNIX machine. This is done by reading bytes bit by bit, converting them to floating-point numbers, then writing results to another file. Useful when data files created by VAX computer must be used on other machines. Written in C language.

COMGEN - A PROGRAM FOR GENERATING FINITE ELEMENT MODELS OF COMPOSITE MATERIALS AT THE MICRO LEVEL (SGI IRIS VERSION)

NASA Technical Reports Server (NTRS)

Melis, M. E.

1994-01-01

A significant percentage of time spent in a typical finite element analysis is taken up in the modeling and assignment of loads and constraints. This process not only requires the analyst to be well-versed in the art of finite element modeling, but also demands familiarity with some sort of preprocessing software in order to complete the task expediently. COMGEN (COmposite Model GENerator) is an interactive FORTRAN program which can be used to create a wide variety of finite element models of continuous fiber composite materials at the micro level. It quickly generates batch or "session files" to be submitted to the finite element pre- and post-processor program, PATRAN. (PDA Engineering, Costa Mesa, CA.) In modeling a composite material, COMGEN assumes that its constituents can be represented by a "unit cell" of a fiber surrounded by matrix material. Two basic cell types are available. The first is a square packing arrangement where the fiber is positioned in the center of a square matrix cell. The second type, hexagonal packing, has the fiber centered in a hexagonal matrix cell. Different models can be created using combinations of square and hexagonal packing schemes. Variations include two- and three- dimensional cases, models with a fiber-matrix interface, and different constructions of unit cells. User inputs include fiber diameter and percent fiber-volume of the composite to be analyzed. In addition, various mesh densities, boundary conditions, and loads can be assigned to the models within COMGEN. The PATRAN program then uses a COMGEN session file to generate finite element models and their associated loads which can then be translated to virtually any finite element analysis code such as NASTRAN or MARC. COMGEN is written in FORTRAN 77 and has been implemented on DEC VAX series computers under VMS and SGI IRIS series workstations under IRIX. If the user has the PATRAN package available, the output can be graphically displayed. Without PATRAN, the output is tabular. The VAX VMS version is available on a 5.25 inch 360K MS-DOS format diskette (standard distribution media) or a 9-track 1600 BPI DEC VAX FILES-11 format magnetic tape, and it requires about 124K of main memory. The standard distribution media for the IRIS version is a .25 inch streaming magnetic tape cartridge in UNIX tar format. The memory requirement for the IRIS version is 627K. COMGEN was developed in 1990. DEC, VAX and VMS are trademarks of Digital Equipment Corporation. PATRAN is a registered trademark of PDA Engineering. SGI IRIS and IRIX are trademarks of Silicon Graphics, Inc. MS-DOS is a registered trademark of Microsoft Corporation. UNIX is a registered trademark of AT&T.

PMARC - PANEL METHOD AMES RESEARCH CENTER

NASA Technical Reports Server (NTRS)

Ashby, D. L.

1994-01-01

Panel methods are moderate cost tools for solving a wide range of engineering problems. PMARC (Panel Method Ames Research Center) is a potential flow panel code that numerically predicts flow fields around complex three-dimensional geometries. PMARC's predecessor was a panel code named VSAERO which was developed for NASA by Analytical Methods, Inc. PMARC is a new program with many additional subroutines and a well-documented code suitable for powered-lift aerodynamic predictions. The program's open architecture facilitates modifications or additions of new features. Another improvement is the adjustable size code which allows for an optimum match between the computer hardware available to the user and the size of the problem being solved. PMARC can be resized (the maximum number of panels can be changed) in a matter of minutes. Several other state-of-the-art PMARC features include internal flow modeling for ducts and wind tunnel test sections, simple jet plume modeling essential for the analysis and design of powered-lift aircraft, and a time-stepping wake model which allows the study of both steady and unsteady motions. PMARC is a low-order panel method, which means the singularities are distributed with constant strength over each panel. In many cases low-order methods can provide nearly the same accuracy as higher order methods (where the singularities are allowed to vary linearly or quadratically over each panel). Low-order methods have the advantage of a shorter computation time and do not require exact matching between panels. The flow problem is solved by assuming that the body is at rest in a moving flow field. The body is modeled as a closed surface which divides space into two regions -- one region contains the flow field of interest and the other contains a fictitious flow. External flow problems, such as a wing in a uniform stream, have the external region as the flow field of interest and the internal flow as the fictitious flow. This arrangement is reversed for internal flow problems where the internal region contains the flow field of interest and the external flow field is fictitious. In either case it is assumed that the velocity potentials in both regions satisfy Laplace's equation. PMARC has extensive geometry modeling capabilities for handling complex, three-dimensional surfaces. As with all panel methods, the geometry must be modeled by a set of panels. For convenience, the geometry is usually subdivided into several pieces and modeled with sets of panels called patches. A patch may be folded over on itself so that opposing sides of the patch form a common line. For example, wings are normally modeled with a folded patch to form the trailing edge of the wing. PMARC also has the capability to automatically generate a closing tip patch. In the case of a wing, a tip patch could be generated to close off the wing's third side. PMARC has a simple jet model for simulating a jet plume in a crossflow. The jet plume shape, trajectory, and entrainment velocities are computed using the Adler/Baron jet in crossflow code. This information is then passed back to PMARC. The wake model in PMARC is a time-stepping wake model. The wake is convected downstream from the wake separation line by the local velocity flowfield. With each time step, a new row of wake panels is added to the wake at the wake separation line. PMARC also allows an initial wake to be specified if desired, or, as a third option, no wakes need be modeled. The effective presentation of results for aerodynamics problems requires the generation of report-quality graphics. PMAPP (ARC-12751), the Panel Method Aerodynamic Plotting Program, (Sterling Software), was written for scientists at NASA's Ames Research Center to plot the aerodynamic analysis results (flow data) from PMARC. PMAPP is an interactive, color-capable graphics program for the DEC VAX or MicroVAX running VMS. It was designed to work with a variety of terminal types and hardcopy devices. PMAPP is available separately from COSMIC. PMARC was written in standard FORTRAN77 using adjustable size arrays throughout the code. Redimensioning PMARC will change the amount of disk space and memory the code requires to be able to run; however, due to its memory requirements, this program does not readily lend itself to implementation on MS-DOS based machines. The program was implemented on an Apple Macintosh (using 2.5 MB of memory) and tested on a VAX/VMS computer. The program is available on a 3.5 inch Macintosh format diskette (standard media) or in VAX BACKUP format on TK50 tape cartridge or 9-track magnetic tape. PMARC was developed in 1989.

Safety and immunogenicity of an oral DNA vaccine encoding Sip of Streptococcus agalactiae from Nile tilapia Oreochromis niloticus delivered by live attenuated Salmonella typhimurium.

PubMed

Huang, L Y; Wang, K Y; Xiao, D; Chen, D F; Geng, Y; Wang, J; He, Y; Wang, E L; Huang, J L; Xiao, G Y

2014-05-01

Attenuated Salmonella typhimurium SL7207 was used as a carrier for a reconstructed DNA vaccine against Streptococcus agalactiae. A 1.02 kb DNA fragment, encoding for a portion of the surface immunogenic protein (Sip) of S. agalactiae was inserted into pVAX1. The recombinant plasmid pVAX1-sip was transfected in EPC cells to detect the transient expression by an indirect immunofluorescence assay, together with Western blot analysis. The pVAX1-sip was transformed by electroporation into SL7207. The stability of pVAX1-sip into Salmonella was over 90% after 50 generations with antibiotic selection in vitro while remained stable over 80% during 35 generations under antibiotic-free conditions. The LD50 of SL/pVAX1-sip was 1.7 × 10(11) CFU/fish by intragastric administration which indicated a quite low virulence. Tilapias were inoculated orally at 10(8) CFU/fish, the recombinant bacteria were found present in intestinal tract, spleens and livers and eventually eliminated from the tissues 4 weeks after immunization. Fish immunized at 10(7), 10(8) and 10(9) CFU/fish with different immunization times caused various levels of serum antibody and an effective protection against lethal challenge with the wild-type strain S. agalactiae. Integration studies showed that the pVAX1-sip did not integrate with tilapia chromosomes. The DNA vaccine SL/pVAX1-sip was proved to be safe and effective in protecting tilapias against S. agalactiae infection. Copyright © 2014 Elsevier Ltd. All rights reserved.

Ada Compiler Validation Summary Report: Certificate Number: 911028I1. 11229 Telesoft, Telegen2, Ada Development System, for VAX to 1750, Version 3.25, MicroVAX 3800 under VAX/VMS Version V5.4 (Host) to MIL-STD-1750A ECSPO ITS RAID Simulator, Version 6.0 (Target)

DTIC Science & Technology

1991-10-28

included as appropriate. 2-1 IMPLEMENTATION DEPENDENCIES The following 185 tests have floating-point type declarations requiring more digits than...SYSTEM.MAX DIGITS : C24113F..Y (20 tests) C? 705F..Y (20 tests) C35706F..Y (20 tests) C35707F..Y (20 tests) C35708F..Y (20 tests) C35802F..Z (21 tests...trademark of Teleoft. TeleGen2m is a trademark of TeleSofL VAX and VMS! are registered trademarks of Digital Equipment Corp. RESTRICTED RIGHTS LEGEND Use

Immune protection of microneme 7 (EmMIC7) against Eimeria maxima challenge in chickens.

PubMed

Huang, Jingwei; Zhang, Zhenchao; Li, Menghui; Song, Xiaokai; Yan, Ruofeng; Xu, Lixin; Li, Xiangrui

2015-10-01

In the present study, the immune protective effects of recombinant microneme protein 7 of Eimeria maxima (rEmMIC7) and a DNA vaccine encoding this antigen (pVAX1-EmMIC7) on experimental challenge were evaluated. Two-week-old chickens were randomly divided into five groups. Experimental groups of chickens were immunized with 100 μg DNA vaccine pVAX1-MIC7 or 200 μg rEmMIC7, while control groups of chickens were injected with pVAX1 plasmid or sterile phosphate buffered saline (PBS). The results showed that the anti-EmMIC7 antibody titres in chickens of both rEmMIC7 and pVAX1-MIC7 groups were significantly higher as compared to PBS and pVAX1 control (P < .05). The splenocytes from both vaccinated groups of chickens displayed significantly greater proliferation response compared with the controls (P < .05). Serum from chickens immunized with pVAX1-MIC7 and rEmMIC7 displayed significantly high levels of interleukin-2, interferon-γ, IL-10, IL-17, tumour growth factor-β and IL-4 (P < .05) compared to those of negative controls. The challenge experiment results showed that both the recombinant antigen and the DNA vaccine could obviously alleviate jejunum lesions, body weight loss and enhance oocyst decrease ratio. The anti-coccidial index (ACI) of the pVAX1-MIC7 group was 167.84, higher than that of the recombinant MIC7 protein group, 167.10. Our data suggested that immunization with EmMIC7 was effective in imparting partial protection against E. maxima challenge in chickens and it could be an effective antigen candidate for the development of new vaccines against E. maxima.

Hard x ray imaging graphics development and literature search

NASA Technical Reports Server (NTRS)

Emslie, A. Gordon

1991-01-01

This report presents work performed between June 1990 and June 1991 and has the following objectives: (1) a comprehensive literature search of imaging technology and coded aperture imaging as well as relevant topics relating to solar flares; (2) an analysis of random number generators; and (3) programming simulation models of hard x ray telescopes. All programs are compatible with NASA/MSFC Space Science LAboratory VAX Cluster and are written in VAX FORTRAN and VAX IDL (Interactive Data Language).

Protection of Nonhuman Primates Against Two Species of Ebola Virus Infection With a Single Complex Adenovirus Vector

DTIC Science & Technology

2010-04-01

glycoproteins of Zaire ebolavirus (ZEBOV) and Sudan ebolavirus (SEBOV) in a single complex adenovirus -based vector (CAdVax). We evaluated our vaccine ...recombinant complex adenovirus vaccine (CAdVax) system, which provides multivalent protection of NHPs against multiple species of filoviruses (33). The...CAdVax vaccine platform is based on a complex, replication-defective adenovirus 5 (Ad5) vector (28–30, 37, 38) that allows for the incorporation of

Immunogenicity of porcine circovirus type 2 nucleic acid vaccine containing CpG motif for mice.

PubMed

Li, Jun; Yu, Jiang; Xu, Shaojian; Shi, Jianli; Xu, Shengnan; Wu, Xiaoyan; Fu, Fang; Peng, Zhe; Zhang, Lingling; Zheng, Shuxuan; Yuan, Xiaoyuan; Cong, Xiaoyan; Sun, Wenbo; Cheng, Kaihui; Du, Yijun; Wu, Jiaqiang; Wang, Jinbao

2016-11-14

This study aimed at reseaching the immune effect of porcine circovirus type 2 (PCV2) DNA vaccine containing CpG motif on mice. A total of 40 6-week-old female BALB/c mice were randomly divided into four groups which were immunized by 18CpG-pVAX1-ORF2, pVAX1-ORF2, pVAX1 and PBS, respectively, and immunized again 2 weeks later. All mice were challenged with 0.2 mL PCV2 cells virulent strain SD (10 6.0 TCID 50 /mL) after 4 weeks. Average daily gain, blood antibody levels, microscopic changes and viremia were detected to estimate the effect of DNA vaccine. The results showed that compared to those of the control mice, groups immunized with pVAX1-ORF2 and 18CpG-pVAX1-ORF2 could induce PCV2-specific antibodies. The PCV2-specific antibodies level of 18 CpG-pVAX1-ORF2 groups was higher significantly than other groups and decreased slowly along with time. There was no distinct pathological damage and viremia occurring in mice that inoculated with CpG motif DNA vaccines. The results demonstrated that the DNA vaccine containing 18 CpG could build up resistibility immunity and reduce immune organ damage on mice.

The Internal Consistency and Validity of the Vaccination Attitudes Examination Scale: A Replication Study.

PubMed

Wood, Louise; Smith, Michael; Miller, Christopher B; O'Carroll, Ronan E

2018-06-19

Vaccinations are important preventative health behaviors. The recently developed Vaccination Attitudes Examination (VAX) Scale aims to measure the reasons behind refusal/hesitancy regarding vaccinations. The aim of this replication study is to conduct an independent test of the newly developed VAX Scale in the UK. We tested (a) internal consistency (Cronbach's α); (b) convergent validity by assessing its relationships with beliefs about medication, medical mistrust, and perceived sensitivity to medicines; and (c) construct validity by testing how well the VAX Scale discriminated between vaccinators and nonvaccinators. A sample of 243 UK adults completed the VAX Scale, the Beliefs About Medicines Questionnaire, the Perceived Sensitivity to Medicines Scale, and the Medical Mistrust Index, in addition to demographics of age, gender, education levels, and social deprivation. Participants were asked (a) whether they received an influenza vaccination in the past year and (b) if they had a young child, whether they had vaccinated the young child against influenza in the past year. The VAX (a) demonstrated high internal consistency (α = .92); (b) was positively correlated with medical mistrust and beliefs about medicines, and less strongly correlated with perceived sensitivity to medicines; and (c) successfully differentiated parental influenza vaccinators from nonvaccinators. The VAX demonstrated good internal consistency, convergent validity, and construct validity in an independent UK sample. It appears to be a useful measure to help us understand the health beliefs that promote or deter vaccination behavior.

TAE+ 5.1 - TRANSPORTABLE APPLICATIONS ENVIRONMENT PLUS, VERSION 5.1 (SUN3 VERSION)

NASA Technical Reports Server (NTRS)

TAE SUPPORT OFFICE

1994-01-01

TAE (Transportable Applications Environment) Plus is an integrated, portable environment for developing and running interactive window, text, and graphical object-based application systems. The program allows both programmers and non-programmers to easily construct their own custom application interface and to move that interface and application to different machine environments. TAE Plus makes both the application and the machine environment transparent, with noticeable improvements in the learning curve. The main components of TAE Plus are as follows: (1) the WorkBench, a What You See Is What You Get (WYSIWYG) tool for the design and layout of a user interface; (2) the Window Programming Tools Package (WPT), a set of callable subroutines that control an application's user interface; and (3) TAE Command Language (TCL), an easy-to-learn command language that provides an easy way to develop an executable application prototype with a run-time interpreted language. The WorkBench tool allows the application developer to interactively construct the layout of an application's display screen by manipulating a set of interaction objects including input items such as buttons, icons, and scrolling text lists. Data-driven graphical objects such as dials, thermometers, and strip charts are also included. TAE Plus updates the strip chart as the data values change. The WorkBench user specifies the windows and interaction objects that will make up the user interface, then specifies the sequence of the user interface dialogue. The description of the designed user interface is then saved into resource files. For those who desire to develop the designed user interface into an operational application, the WorkBench tool also generates source code (C, Ada, and TCL) which fully controls the application's user interface through function calls to the WPTs. The WPTs are the runtime services used by application programs to display and control the user interfaces. Since the WPTs access the workbench-generated resource files during each execution, details such as color, font, location, and object type remain independent from the application code, allowing changes to the user interface without recompiling and relinking. The Silicon Graphics version of TAE Plus now has a font caching scheme and a color caching scheme to make color allocation more efficient. In addition to WPTs, TAE Plus can control interaction of objects from the interpreted TAE Command Language. TCL provides an extremely powerful means for the more experienced developer to quickly prototype an application's use of TAE Plus interaction objects and add programming logic without the overhead of compiling or linking. TAE Plus requires MIT's X Window System, Version 11 Release 4, and the Open Software Foundation's Motif Toolkit 1.1 or 1.1.1. The Workbench and WPTs are written in C++ and the remaining code is written in C. TAE Plus is available by license for an unlimited time period. The licensed program product includes the TAE Plus source code and one set of supporting documentation. Additional documentation may be purchased separately at the price indicated below. The amount of disk space required to load the TAE Plus tar format tape is between 35Mb and 67Mb depending on the machine version. The recommended minimum memory is 12Mb. Each TAE Plus platform delivery tape includes pre-built libraries and executable binary code for that particular machine, as well as source code, so users do not have to do an installation. Users wishing to recompile the source will need both a C compiler and either GNU's C++ Version 1.39 or later, or a C++ compiler based on AT&T 2.0 cfront. TAE Plus comes with InterViews and idraw, two software packages developed by Stanford University and integrated in TAE Plus. TAE Plus was developed in 1989 and version 5.1 was released in 1991. TAE Plus is currently available on media suitable for eight different machine platforms: 1) DEC VAX computers running VMS 5.3 or higher (TK50 cartridge in VAX BACKUP format), 2) DEC VAXstations running ULTRIX 4.1 or later (TK50 cartridge in UNIX tar format), 3) DEC RISC workstations running ULTRIX 4.1 or later (TK50 cartridge in UNIX tar format), 4) HP9000 Series 300/400 computers running HP-UX 8.0 (.25 inch HP-preformatted tape cartridge in UNIX tar format), 5) HP9000 Series 700 computers running HP-UX 8.05 (HP 4mm DDS DAT tape cartridge in UNIX tar format), 6) Sun3 series computers running SunOS 4.1.1 (.25 inch tape cartridge in UNIX tar format), 7) Sun4 (SPARC) series computers running SunOS 4.1.1 (.25 inch tape cartridge in UNIX tar format), and 8) SGI Indigo computers running IRIX 4.0.1 and IRIX/Motif 1.0.1 (.25 inch IRIS tape cartridge in UNIX tar format). An optional Motif Object Code License is available for either Sun version. TAE is a trademark of the National Aeronautics and Space Administration. X Window System is a trademark of the Massachusetts Institute of Technology. Motif is a trademark of the Open Software Foundation. DEC, VAX, VMS, TK50 and ULTRIX are trademarks of Digital Equipment Corporation. HP9000 and HP-UX are trademarks of Hewlett-Packard Co. Sun3, Sun4, SunOS, and SPARC are trademarks of Sun Microsystems, Inc. SGI and IRIS are registered trademarks of Silicon Graphics, Inc.

TAE+ 5.1 - TRANSPORTABLE APPLICATIONS ENVIRONMENT PLUS, VERSION 5.1 (SUN3 VERSION WITH MOTIF)

NASA Technical Reports Server (NTRS)

TAE SUPPORT OFFICE

1994-01-01

TAE (Transportable Applications Environment) Plus is an integrated, portable environment for developing and running interactive window, text, and graphical object-based application systems. The program allows both programmers and non-programmers to easily construct their own custom application interface and to move that interface and application to different machine environments. TAE Plus makes both the application and the machine environment transparent, with noticeable improvements in the learning curve. The main components of TAE Plus are as follows: (1) the WorkBench, a What You See Is What You Get (WYSIWYG) tool for the design and layout of a user interface; (2) the Window Programming Tools Package (WPT), a set of callable subroutines that control an application's user interface; and (3) TAE Command Language (TCL), an easy-to-learn command language that provides an easy way to develop an executable application prototype with a run-time interpreted language. The WorkBench tool allows the application developer to interactively construct the layout of an application's display screen by manipulating a set of interaction objects including input items such as buttons, icons, and scrolling text lists. Data-driven graphical objects such as dials, thermometers, and strip charts are also included. TAE Plus updates the strip chart as the data values change. The WorkBench user specifies the windows and interaction objects that will make up the user interface, then specifies the sequence of the user interface dialogue. The description of the designed user interface is then saved into resource files. For those who desire to develop the designed user interface into an operational application, the WorkBench tool also generates source code (C, Ada, and TCL) which fully controls the application's user interface through function calls to the WPTs. The WPTs are the runtime services used by application programs to display and control the user interfaces. Since the WPTs access the workbench-generated resource files during each execution, details such as color, font, location, and object type remain independent from the application code, allowing changes to the user interface without recompiling and relinking. The Silicon Graphics version of TAE Plus now has a font caching scheme and a color caching scheme to make color allocation more efficient. In addition to WPTs, TAE Plus can control interaction of objects from the interpreted TAE Command Language. TCL provides an extremely powerful means for the more experienced developer to quickly prototype an application's use of TAE Plus interaction objects and add programming logic without the overhead of compiling or linking. TAE Plus requires MIT's X Window System, Version 11 Release 4, and the Open Software Foundation's Motif Toolkit 1.1 or 1.1.1. The Workbench and WPTs are written in C++ and the remaining code is written in C. TAE Plus is available by license for an unlimited time period. The licensed program product includes the TAE Plus source code and one set of supporting documentation. Additional documentation may be purchased separately at the price indicated below. The amount of disk space required to load the TAE Plus tar format tape is between 35Mb and 67Mb depending on the machine version. The recommended minimum memory is 12Mb. Each TAE Plus platform delivery tape includes pre-built libraries and executable binary code for that particular machine, as well as source code, so users do not have to do an installation. Users wishing to recompile the source will need both a C compiler and either GNU's C++ Version 1.39 or later, or a C++ compiler based on AT&T 2.0 cfront. TAE Plus comes with InterViews and idraw, two software packages developed by Stanford University and integrated in TAE Plus. TAE Plus was developed in 1989 and version 5.1 was released in 1991. TAE Plus is currently available on media suitable for eight different machine platforms: 1) DEC VAX computers running VMS 5.3 or higher (TK50 cartridge in VAX BACKUP format), 2) DEC VAXstations running ULTRIX 4.1 or later (TK50 cartridge in UNIX tar format), 3) DEC RISC workstations running ULTRIX 4.1 or later (TK50 cartridge in UNIX tar format), 4) HP9000 Series 300/400 computers running HP-UX 8.0 (.25 inch HP-preformatted tape cartridge in UNIX tar format), 5) HP9000 Series 700 computers running HP-UX 8.05 (HP 4mm DDS DAT tape cartridge in UNIX tar format), 6) Sun3 series computers running SunOS 4.1.1 (.25 inch tape cartridge in UNIX tar format), 7) Sun4 (SPARC) series computers running SunOS 4.1.1 (.25 inch tape cartridge in UNIX tar format), and 8) SGI Indigo computers running IRIX 4.0.1 and IRIX/Motif 1.0.1 (.25 inch IRIS tape cartridge in UNIX tar format). An optional Motif Object Code License is available for either Sun version. TAE is a trademark of the National Aeronautics and Space Administration. X Window System is a trademark of the Massachusetts Institute of Technology. Motif is a trademark of the Open Software Foundation. DEC, VAX, VMS, TK50 and ULTRIX are trademarks of Digital Equipment Corporation. HP9000 and HP-UX are trademarks of Hewlett-Packard Co. Sun3, Sun4, SunOS, and SPARC are trademarks of Sun Microsystems, Inc. SGI and IRIS are registered trademarks of Silicon Graphics, Inc.

Interfacing the VAX 11/780 Using Berkeley Unix 4.2.BSD and Ethernet Based Xerox Network Systems. Volume 1.

DTIC Science & Technology

1984-12-01

3Com Corporation ....... A-18 Ethernet Controller Support . . . . . . A-19 Host Systems Support . . . . . . . . . A-20 Personal Computers Support...A-23 VAX EtherSeries Software 0 * A-23 Network Research Corporation . o o o . o A-24 File Transfer Service . . . . o A-25 Virtual Terminal Service 0...Control office is planning to acquire a Digital Equipment Corporation VAX 11/780 mainframe computer with the Unix Berkeley 4.2BSD operating system. They

AUTOCLASS III - AUTOMATIC CLASS DISCOVERY FROM DATA

NASA Technical Reports Server (NTRS)

Cheeseman, P. C.

1994-01-01

The program AUTOCLASS III, Automatic Class Discovery from Data, uses Bayesian probability theory to provide a simple and extensible approach to problems such as classification and general mixture separation. Its theoretical basis is free from ad hoc quantities, and in particular free of any measures which alter the data to suit the needs of the program. As a result, the elementary classification model used lends itself easily to extensions. The standard approach to classification in much of artificial intelligence and statistical pattern recognition research involves partitioning of the data into separate subsets, known as classes. AUTOCLASS III uses the Bayesian approach in which classes are described by probability distributions over the attributes of the objects, specified by a model function and its parameters. The calculation of the probability of each object's membership in each class provides a more intuitive classification than absolute partitioning techniques. AUTOCLASS III is applicable to most data sets consisting of independent instances, each described by a fixed length vector of attribute values. An attribute value may be a number, one of a set of attribute specific symbols, or omitted. The user specifies a class probability distribution function by associating attribute sets with supplied likelihood function terms. AUTOCLASS then searches in the space of class numbers and parameters for the maximally probable combination. It returns the set of class probability function parameters, and the class membership probabilities for each data instance. AUTOCLASS III is written in Common Lisp, and is designed to be platform independent. This program has been successfully run on Symbolics and Explorer Lisp machines. It has been successfully used with the following implementations of Common LISP on the Sun: Franz Allegro CL, Lucid Common Lisp, and Austin Kyoto Common Lisp and similar UNIX platforms; under the Lucid Common Lisp implementations on VAX/VMS v5.4, VAX/Ultrix v4.1, and MIPS/Ultrix v4, rev. 179; and on the Macintosh personal computer. The minimum Macintosh required is the IIci. This program will not run under CMU Common Lisp or VAX/VMS DEC Common Lisp. A minimum of 8Mb of RAM is required for Macintosh platforms and 16Mb for workstations. The standard distribution medium for this program is a .25 inch streaming magnetic tape cartridge in UNIX tar format. It is also available on a 3.5 inch diskette in UNIX tar format and a 3.5 inch diskette in Macintosh format. An electronic copy of the documentation is included on the distribution medium. AUTOCLASS was developed between March 1988 and March 1992. It was initially released in May 1991. Sun is a trademark of Sun Microsystems, Inc. UNIX is a registered trademark of AT&T Bell Laboratories. DEC, VAX, VMS, and ULTRIX are trademarks of Digital Equipment Corporation. Macintosh is a trademark of Apple Computer, Inc. Allegro CL is a registered trademark of Franz, Inc.

Another Program For Generating Interactive Graphics

NASA Technical Reports Server (NTRS)

Costenbader, Jay; Moleski, Walt; Szczur, Martha; Howell, David; Engelberg, Norm; Li, Tin P.; Misra, Dharitri; Miller, Philip; Neve, Leif; Wolf, Karl;

Update: Temporary Total Depletion of U.S. Licensed Yellow Fever Vaccine for Civilian Travelers Addressed by Investigational New Drug Use of Imported Stamaril Vaccine.

PubMed

Gershman, Mark D; Sotir, Mark J

2017-07-28

Sanofi Pasteur, the manufacturer of the only yellow fever vaccine (YF-VAX) licensed in the United States, has announced that their stock of YF-VAX is totally depleted as of July 24, 2017. YF-VAX for civilian use will be unavailable for ordering from Sanofi Pasteur until mid-2018, when their new manufacturing facility is expected to be completed. However, YF-VAX might be available at some clinics for several months, until remaining supplies at those sites are exhausted. In anticipation of this temporary total depletion, in 2016, Sanofi Pasteur submitted an expanded access investigational new drug application to the Food and Drug Administration to allow for importation and use of Stamaril. The Food and Drug Administration accepted Sanofi Pasteur's application in October 2016.

Structure of RiVax: a recombinant ricin vaccine

DOE Office of Scientific and Technical Information (OSTI.GOV)

Legler, Patricia M.; Brey, Robert N.; Smallshaw, Joan E.

The X-ray crystal structure (at 2.1 Å resolution) of an immunogen under development as part of a ricin vaccine for humans is presented and structure-based analysis of the results was conducted with respect to related proteins and the known determinants for inducing or suppressing the protective immune response. RiVax is a recombinant protein that is currently under clinical development as part of a human vaccine to protect against ricin poisoning. RiVax includes ricin A-chain (RTA) residues 1–267 with two intentional amino-acid substitutions, V76M and Y80A, aimed at reducing toxicity. Here, the crystal structure of RiVax was solved to 2.1 Åmore » resolution and it was shown that it is superposable with that of the ricin toxin A-chain from Ricinus communis with a root-mean-square deviation of 0.6 Å over 258 C{sup α} atoms. The RiVax structure is also compared with the recently determined structure of another potential ricin-vaccine immunogen, RTA 1–33/44–198 R48C/T77C. Finally, the locations and solvent-exposure of two toxin-neutralizing B-cell epitopes were examined and it was found that these epitopes are within or near regions predicted to be involved in catalysis. The results demonstrate the composition of the RiVax clinical material and will guide ongoing protein-engineering strategies to develop improved immunogens.« less

A prospective randomized controlled study of VAX-D and TENS for the treatment of chronic low back pain.

PubMed

Sherry, E; Kitchener, P; Smart, R

2001-10-01

Low back pain is one of the most significant medical and socioeconomic problems in modern society. International guidelines call for evidence-based management for the pain and disability associated with musculoskeletal disorders. The purpose of this randomized controlled trial is to address the question of efficacy and appropriateness of vertebral axial decompression (VAX-D) therapy, a new technology that has been shown in clinical research to create negative intradiscal pressures, and has been shown to be effective in treating patients presenting with chronic low back pain (> 3 months duration) with associated leg pain. Successful outcome was defined as a 50% reduction in pain utilizing a 10 cm Visual Analog Pain Scale and an improvement in the level of functioning as measured by patient-nominated disability ratings. Patients were randomly assigned to VAX-D or to TENS which was used as a control treatment or placebo. The TENS treatment demonstrated a success rate of 0%, while VAX-D demonstrated a success rate of 68.4% (p < 0.001). A statistically significant reduction in pain and improvement in functional outcome was obtained in patients with chronic low back pain treated with VAX-D.

Software fault tolerance in computer operating systems

NASA Technical Reports Server (NTRS)

Iyer, Ravishankar K.; Lee, Inhwan

1994-01-01

This chapter provides data and analysis of the dependability and fault tolerance for three operating systems: the Tandem/GUARDIAN fault-tolerant system, the VAX/VMS distributed system, and the IBM/MVS system. Based on measurements from these systems, basic software error characteristics are investigated. Fault tolerance in operating systems resulting from the use of process pairs and recovery routines is evaluated. Two levels of models are developed to analyze error and recovery processes inside an operating system and interactions among multiple instances of an operating system running in a distributed environment. The measurements show that the use of process pairs in Tandem systems, which was originally intended for tolerating hardware faults, allows the system to tolerate about 70% of defects in system software that result in processor failures. The loose coupling between processors which results in the backup execution (the processor state and the sequence of events occurring) being different from the original execution is a major reason for the measured software fault tolerance. The IBM/MVS system fault tolerance almost doubles when recovery routines are provided, in comparison to the case in which no recovery routines are available. However, even when recovery routines are provided, there is almost a 50% chance of system failure when critical system jobs are involved.

The proposed monitoring system for the Fermilab D0 colliding beams detector

NASA Astrophysics Data System (ADS)

Goodwin, Robert; Florian, Robert; Johnson, Marvin; Jones, Alan; Shea, Mike

1986-06-01

The Fermilab D0 Detector is a collaborative effort that includes seventeen universities and national laboratories. The monitoring and control system for this detector will be separate from the online detector data system. A distributed, stand-alone, microprocessor-based system is being designed to allow monitoring and control functions to be available to the collaborators at their home institutions during the design, fabrication, and testing phases of the project. Individual stations are VMEbus-based 68000 systems that are networked together during installation using an ARCnet (by Datapoint Corporation) Local Area Network. One station, perhaps a MicroVAX, would have a hard disk to store a backup copy of the distributed database located in non-volatile RAM in the local stations. This station would also serve as a gateway to the online system, so that data from the control system will be available for logging with the detector data. Apple Macintosh personal computers are being developed for use as the local control consoles. Each would be interfaced to ARCnet to provide access to all control system data. Through the use of bit-mapped graphics with multiple windows and pull-down menus, a cost effective, flexible display system can be provided, taking advantage of familiar modern software tools to support the operator interface.

Evaluation of the immune response induced by DNA vaccines expressing MIF and MCD-1 genes of Trichinella spiralis in BALB/c mice.

PubMed

Tang, F; Xu, L; Yan, R; Song, X; Li, X

2012-12-01

Plasmids expressing macrophage migration inhibitory factor (MIF) of Trichinella spiralis (TsMIF), multi-cystatin-like domain protein (MCD-1) of T. spiralis (TsMCD-1), or co-expressing TsMIF and TsMCD-1 were constructed with a pVAX1 vector. Their ability to generate a protective immune response against T. spiralis infection was evaluated in BALB/c mice. Groups of mice were immunized twice at 2-week intervals with 100 μg of recombinant plasmids pVAX1-Tsmif, pVAX1-Tsmcd-1 or pVAX1-Tsmif-Tsmcd-1. Control animals were immunized with phosphate-buffered saline (PBS) or blank vector plasmid. Specific antibody levels (IgG, IgG1, IgG2a, IgG2b, IgM, IgA, IgE) against the recombinant protein TsMIF-TsMCD-1, serum cytokines (interferon (IFN)-γ, interleukin (IL)-4, IL-5, transforming growth factor (TGF)-β1 and IL-17) and CD4+/CD8+ T cells were monitored. Challenge infection was performed 2 weeks following the second immunization and worm burden was assayed at 35 days post-challenge. Vaccination with pVAX1-Tsmif induced moderate serum IFN-γ and increases of CD4+ and CD8+ T cells, but no specific immunoglobulin antibody response. Vaccination with pVAX1-Tsmcd-1 induced a predominant Th1 antibody (IgG2a and IgG2b) response and strong levels of serum IFN-γ, and increases of CD4+ T cells. Importantly, co-expression of TsMIF and TsMCD-1 in DNA immunization produced more serum IFN-γ and markedly enhanced CD4+ and CD8+ T cells than the single DNA vaccine of the two genes. Challenge infection demonstrated that immunization with pVAX1-Tsmif-Tsmcd-1 reduced worm burdens (by 23.17%; P < 0.05).

Comparative Genomics and Immunoinformatics Approach for the Identification of Vaccine Candidates for Enterohemorrhagic Escherichia coli O157:H7

PubMed Central

García-Angulo, Víctor A.; Kalita, Anjana; Kalita, Mridul; Lozano, Luis

2014-01-01

Enterohemorrhagic Escherichia coli (EHEC) O157:H7 strains are major human food-borne pathogens, responsible for bloody diarrhea and hemolytic-uremic syndrome worldwide. Thus far, there is no vaccine for humans against EHEC infections. In this study, a comparative genomics analysis was performed to identify EHEC-specific antigens useful as potential vaccines. The genes present in both EHEC EDL933 and Sakai strains but absent in nonpathogenic E. coli K-12 and HS strains were subjected to an in silico analysis to identify secreted or surface-expressed proteins. We obtained a total of 65 gene-encoding protein candidates, which were subjected to immunoinformatics analysis. Our criteria of selection aided in categorizing the candidates as high, medium, and low priority. Three members of each group were randomly selected and cloned into pVAX-1. Candidates were pooled accordingly to their priority group and tested for immunogenicity against EHEC O157:H7 using a murine model of gastrointestinal infection. The high-priority (HP) pool, containing genes encoding a Lom-like protein (pVAX-31), a putative pilin subunit (pVAX-12), and a fragment of the type III secretion structural protein EscC (pVAX-56.2), was able to induce the production of EHEC IgG and sIgA in sera and feces. HP candidate-immunized mice displayed elevated levels of Th2 cytokines and diminished cecum colonization after wild-type challenge. Individually tested HP vaccine candidates showed that pVAX-12 and pVAX-56.2 significantly induced Th2 cytokines and production of fecal EHEC sIgA, with pVAX-56.2 reducing EHEC cecum colonization. We describe here a bioinformatics approach able to identify novel vaccine candidates potentially useful for preventing EHEC O157:H7 infections. PMID:24595137

VAX-Gerber node link. Revision 1. 0

DOE Office of Scientific and Technical Information (OSTI.GOV)

Isobe, G.W.

1985-12-01

A communications link between the CADDE VAX 11/750 and the Gerber Photo-Plotter 4135 was desired at LLNL. The process of creating this link is discussed and the features of this project are described. 4 figs.

The TAVERNS emulator: An Ada simulation of the space station data communications network and software development environment

NASA Technical Reports Server (NTRS)

Howes, Norman R.

1986-01-01

The Space Station DMS (Data Management System) is the onboard component of the Space Station Information System (SSIS) that includes the computers, networks and software that support the various core and payload subsystems of the Space Station. TAVERNS (Test And Validation Environment for Remote Networked Systems) is a distributed approach for development and validation of application software for Space Station. The TAVERNS concept assumes that the different subsystems will be developed by different contractors who may be geographically separated. The TAVERNS Emulator is an Ada simulation of a TAVERNS on the ASD VAX. The software services described in the DMS Test Bed User's Manual are being emulated on the VAX together with simulations of some of the core subsystems and a simulation of the DCN. The TAVERNS Emulator will be accessible remotely from any VAX that can communicate with the ASD VAX.

IBM NJE protocol emulator for VAX/VMS

DOE Office of Scientific and Technical Information (OSTI.GOV)

Engert, D.E.

1981-01-01

Communications software has been written at Argonne National Laboratory to enable a VAX/VMS system to participate as an end-node in a standard IBM network by emulating the Network Job Entry (NJE) protocol. NJE is actually a collection of programs that support job networking for the operating systems used on most large IBM-compatible computers (e.g., VM/370, MVS with JES2 or JES3, SVS, MVT with ASP or HASP). Files received by the VAX can be printed or saved in user-selected disk files. Files sent to the network can be routed to any node in the network for printing, punching, or job submission,more » as well as to a VM/370 user's virtual reader. Files sent from the VAX are queued and transmitted asynchronously to allow users to perform other work while files are awaiting transmission. No changes are required to the IBM software.« less

VAX CLuster upgrade: Report of a CPC task force

DOE Office of Scientific and Technical Information (OSTI.GOV)

Hanson, J.; Berry, H.; Kessler, P.

The CSCF VAX cluster provides interactive computing for 100 users during prime time, plus a considerable amount of daytime and overnight batch processing. While this cluster represents less than 10% of the VAX computing power at BNL (6 MIPS out of 70), it has served as an important center for this larger network, supporting special hardware and software too expensive to maintain on every machine. In addition, it is the only unrestricted facility available to VAX/VMS users (other machines are typically dedicated to special projects). This committee's analysis shows that the cpu's on the CSCF cluster are currently badly oversaturated,more » frequently giving extremely poor interactive response. Short batch jobs (a necessary part of interactive work) typically take 3 to 4 times as long to execute as they would on an idle machine. There is also an immediate need for more scratch disk space and user permanent file space.« less

Heterogeneous distributed databases: A case study

NASA Technical Reports Server (NTRS)

Stewart, Tracy R.; Mukkamala, Ravi

1991-01-01

Alternatives are reviewed for accessing distributed heterogeneous databases and a recommended solution is proposed. The current study is limited to the Automated Information Systems Center at the Naval Sea Combat Systems Engineering Station at Norfolk, VA. This center maintains two databases located on Digital Equipment Corporation's VAX computers running under the VMS operating system. The first data base, ICMS, resides on a VAX11/780 and has been implemented using VAX DBMS, a CODASYL based system. The second database, CSA, resides on a VAX 6460 and has been implemented using the ORACLE relational database management system (RDBMS). Both databases are used for configuration management within the U.S. Navy. Different customer bases are supported by each database. ICMS tracks U.S. Navy ships and major systems (anti-sub, sonar, etc.). Even though the major systems on ships and submarines have totally different functions, some of the equipment within the major systems are common to both ships and submarines.

Storage Media for Microcomputers.

ERIC Educational Resources Information Center

Trautman, Rodes

1983-01-01

Reviews computer storage devices designed to provide additional memory for microcomputers--chips, floppy disks, hard disks, optical disks--and describes how secondary storage is used (file transfer, formatting, ingredients of incompatibility); disk/controller/software triplet; magnetic tape backup; storage volatility; disk emulator; and…

Good Manufacturing Practices production and analysis of a DNA vaccine against dental caries.

PubMed

Yang, Ya-ping; Li, Yu-hong; Zhang, Ai-hua; Bi, Lan; Fan, Ming-wen

2009-11-01

To prepare a clinical-grade anti-caries DNA vaccine pGJA-P/VAX and explore its immune effect and protective efficacy against a cariogenic bacterial challenge. A large-scale industrial production process was developed under Good Manufacturing Practices (GMP) by combining and optimizing common unit operations such as alkaline lysis, precipitation, endotoxin removal and column chromatography. Quality controls of the purified bulk and final lyophilized vaccine were conducted according to authoritative guidelines. Mice and gnotobiotic rats were intranasally immunized with clinical-grade pGJA-P/VAX with chitosan. Antibody levels of serum IgG and salivary SIgA were assessed by an enzyme-linked immunosorbent assay (ELISA), and caries activity was evaluated by the Keyes method. pGJA-P/VAX and pVAX1 prepared by a laboratory-scale commercial kit were used as controls. The production process proved to be scalable and reproducible. Impurities including host protein, residual RNA, genomic DNA and endotoxin in the purified plasmid were all under the limits of set specifications. Intranasal vaccination with clinical-grade pGJA-P/VAX induced higher serum IgG and salivary SIgA in both mice and gnotobiotic rats. While in the experimental caries model, the enamel (E), dentinal slight (Ds), and dentinal moderate (Dm) caries lesions were reduced by 21.1%, 33.0%, and 40.9%, respectively. The production process under GMP was efficient in preparing clinical-grade pGJA-P/VAX with high purity and intended effectiveness, thus facilitating future clinical trials for the anti-caries DNA vaccine.

SARA - SURE/ASSIST RELIABILITY ANALYSIS WORKSTATION (VAX VMS VERSION)

NASA Technical Reports Server (NTRS)

Butler, R. W.

1994-01-01

SARA, the SURE/ASSIST Reliability Analysis Workstation, is a bundle of programs used to solve reliability problems. The mathematical approach chosen to solve a reliability problem may vary with the size and nature of the problem. The Systems Validation Methods group at NASA Langley Research Center has created a set of four software packages that form the basis for a reliability analysis workstation, including three for use in analyzing reconfigurable, fault-tolerant systems and one for analyzing non-reconfigurable systems. The SARA bundle includes the three for reconfigurable, fault-tolerant systems: SURE reliability analysis program (COSMIC program LAR-13789, LAR-14921); the ASSIST specification interface program (LAR-14193, LAR-14923), and PAWS/STEM reliability analysis programs (LAR-14165, LAR-14920). As indicated by the program numbers in parentheses, each of these three packages is also available separately in two machine versions. The fourth package, which is only available separately, is FTC, the Fault Tree Compiler (LAR-14586, LAR-14922). FTC is used to calculate the top-event probability for a fault tree which describes a non-reconfigurable system. PAWS/STEM and SURE are analysis programs which utilize different solution methods, but have a common input language, the SURE language. ASSIST is a preprocessor that generates SURE language from a more abstract definition. ASSIST, SURE, and PAWS/STEM are described briefly in the following paragraphs. For additional details about the individual packages, including pricing, please refer to their respective abstracts. ASSIST, the Abstract Semi-Markov Specification Interface to the SURE Tool program, allows a reliability engineer to describe the failure behavior of a fault-tolerant computer system in an abstract, high-level language. The ASSIST program then automatically generates a corresponding semi-Markov model. A one-page ASSIST-language description may result in a semi-Markov model with thousands of states and transitions. The ASSIST program also includes model-reduction techniques to facilitate efficient modeling of large systems. The semi-Markov model generated by ASSIST is in the format needed for input to SURE and PAWS/STEM. The Semi-Markov Unreliability Range Evaluator, SURE, is an analysis tool for reconfigurable, fault-tolerant systems. SURE provides an efficient means for calculating accurate upper and lower bounds for the death state probabilities for a large class of semi-Markov models, not just those which can be reduced to critical-pair architectures. The calculated bounds are close enough (usually within 5 percent of each other) for use in reliability studies of ultra-reliable computer systems. The SURE bounding theorems have algebraic solutions and are consequently computationally efficient even for large and complex systems. SURE can optionally regard a specified parameter as a variable over a range of values, enabling an automatic sensitivity analysis. SURE output is tabular. The PAWS/STEM package includes two programs for the creation and evaluation of pure Markov models describing the behavior of fault-tolerant reconfigurable computer systems: the Pade Approximation with Scaling (PAWS) and Scaled Taylor Exponential Matrix (STEM) programs. PAWS and STEM produce exact solutions for the probability of system failure and provide a conservative estimate of the number of significant digits in the solution. Markov models of fault-tolerant architectures inevitably lead to numerically stiff differential equations. Both PAWS and STEM have the capability to solve numerically stiff models. These complementary programs use separate methods to determine the matrix exponential in the solution of the model's system of differential equations. In general, PAWS is better suited to evaluate small and dense models. STEM operates at lower precision, but works faster than PAWS for larger models. The programs that comprise the SARA package were originally developed for use on DEC VAX series computers running VMS and were later ported for use on Sun series computers running SunOS. They are written in C-language, Pascal, and FORTRAN 77. An ANSI compliant C compiler is required in order to compile the C portion of the Sun version source code. The Pascal and FORTRAN code can be compiled on Sun computers using Sun Pascal and Sun Fortran. For the VMS version, VAX C, VAX PASCAL, and VAX FORTRAN can be used to recompile the source code. The standard distribution medium for the VMS version of SARA (COS-10041) is a 9-track 1600 BPI magnetic tape in VMSINSTAL format. It is also available on a TK50 tape cartridge in VMSINSTAL format. Executables are included. The standard distribution medium for the Sun version of SARA (COS-10039) is a .25 inch streaming magnetic tape cartridge in UNIX tar format. Both Sun3 and Sun4 executables are included. Electronic copies of the ASSIST user's manual in TeX and PostScript formats are provided on the distribution medium. DEC, VAX, VMS, and TK50 are registered trademarks of Digital Equipment Corporation. Sun, Sun3, Sun4, and SunOS are trademarks of Sun Microsystems, Inc. TeX is a trademark of the American Mathematical Society. PostScript is a registered trademark of Adobe Systems Incorporated.

Geophysical Plasmas and Atmospheric Modeling.

DTIC Science & Technology

1986-07-01

Vay which, before any form of coupling occurs, is Vax Vay - 0. Therefore the laminar force eE x/ma and the turbulent force v*jVax - VdI - v*Vd will...and turbulent forces will dominate. The turbulent forces will also dominate even at t >> aI as long v* > na jVax - VdI /Vd. Another important point...0n 0U 0 0M Fig. 8. Plot of logl0 I/il versus logio v (v is mode number from I to 2048 ) for a trapezoid of unit area. a - 224. and h, - 240. The lower

A File Archival System

NASA Technical Reports Server (NTRS)

Fanselow, J. L.; Vavrus, J. L.

1984-01-01

ARCH, file archival system for DEC VAX, provides for easy offline storage and retrieval of arbitrary files on DEC VAX system. System designed to eliminate situations that tie up disk space and lead to confusion when different programers develop different versions of same programs and associated files.

Efficacy of the nicotine vaccine 3'-AmNic-rEPA (NicVAX) co-administered with varenicline and counselling for smoking cessation: a randomized placebo-controlled trial.

PubMed

Hoogsteder, Philippe H J; Kotz, Daniel; van Spiegel, Paul I; Viechtbauer, Wolfgang; van Schayck, Onno C P

2014-08-01

Nicotine vaccination has been proposed as a possible treatment to aid smoking cessation. First efficacy results of the nicotine vaccine 3'-AmNic-rEPA (NicVAX) showed that only a subgroup of the top 30% antibody responders achieved higher abstinence rates than placebo. The present study examined the efficacy of adding NicVAX versus placebo to varenicline and behavioural support as an aid in smoking cessation and relapse prevention. Randomized placebo-controlled trial. Two research centres (Maastricht University Medical Centre and Slotervaart Hospital) in the Netherlands. A total of 558 smokers were assigned randomly to six injections with NicVAX (n = 278) or placebo (n = 280) both co-administered with open label varenicline and behavioural support. Outcomes were prolonged carbon monoxide-validated abstinence from weeks 9 to 52 (primary) and weeks 37 to 52 (secondary). We also performed a pre-planned subgroup analysis in the top 30% antibody responders. There was no difference in abstinence rates between NicVAX and placebo from weeks 9 to 52 [27.7 versus 30.0%, odds ratio (OR) = 0.89, 95% confidence interval (CI) = 0.62-1.29] or weeks 37 to 52 (33.8 versus 33.2%, OR = 1.03, 95% CI = 0.73-1.46). The top 30% antibody responders, compared to the placebo group, showed a non-significant tendency towards higher abstinence rates from weeks 37 to 52 (42.2 versus 33.2%, OR = 1.47, 95% CI = 0.89-2.42). The nicotine vaccine, NicVAX, does not appear to improve the chances of stopping smoking when given in addition to varenicline and behavioural support. © 2014 Society for the Study of Addiction.

Protective Efficacy of Coccidial Common Antigen Glyceraldehyde 3-Phosphate Dehydrogenase (GAPDH) against Challenge with Three Eimeria Species

PubMed Central

Tian, Lu; Li, Wenyu; Huang, Xinmei; Tian, Di; Liu, Jianhua; Yang, Xinchao; Liu, Lianrui; Yan, Ruofeng; Xu, Lixin; Li, Xiangrui; Song, Xiaokai

2017-01-01

Coccidiosis is an intestinal disorder of poultry and often caused by simultaneous infections of several Eimeria species. GAPDH is one of the immunogenic common antigens among Eimeria tenella, E. acervulina, and E. maxima identified in our previous study. The present study was performed to further evaluate its immunogenicity and protective efficacy. The genes of GAPDH cloned from E. acervulina and E. maxima were named as EaGAPDH and EmGAPDH, respectively. The immunogenicity of recombinant proteins of EaGAPDH and EmGAPDH were analyzed by Western blot. The transcription and expression of pVAX-EaGAPDH and pVAX-EmGAPDH in the injected muscles were detected by reverse transcription PCR (RT-PCR) and Western blot, respectively. GAPDH-induced changes of T lymphocytes subpopulation, cytokines production, and antibody were determined using flow cytometry, quantitative real-time PCR (qPCR), and ELISA, respectively. Finally, the protective efficacies of pVAX-EaGAPDH and pVAX-EmGAPDH were evaluated by vaccination and challenge experiments. The results revealed that the recombinant GAPDH proteins reacted with the corresponding chicken antisera. The EaGAPDH genes were successfully transcribed and expressed in the injected muscles. Vaccination with pVAX-EaGAPDH and pVAX-EmGAPDH significantly increased the proportion of CD4+ and CD8+ T lymphocytes, the cytokines productions of IFN-γ, IL-2, IL-4 et al., and IgG antibody levels compared to controls. The vaccination increased the weight gains, decreased the oocyst outputs, alleviate the enteric lesions compared to controls, and induced moderate anti-coccidial index (ACI). In conclusion, the coccidial common antigen of GAPDH induced significant humoral and cellular immune response and effective protection against E. tenella, E. acervulina, E. maxima, and mixed infection of the three Eimeria species. PMID:28769877

Vaccination with a DNA vaccine encoding Toxoplasma gondii ROP54 induces protective immunity against toxoplasmosis in mice.

PubMed

Yang, Wen-Bin; Zhou, Dong-Hui; Zou, Yang; Chen, Kai; Liu, Qing; Wang, Jin-Lei; Zhu, Xing-Quan; Zhao, Guang-Hui

2017-12-01

Toxoplasma gondii is an obligatory intracellular protozoan, which infects most of the warm-blooded animals, causing serious public health problems and enormous economic losses worldwide. The rhoptry effector protein 54 (ROP54) has been indicated as a virulence factor that promotes Toxoplasma infection by modulating GBP2 loading onto parasite-containing vacuoles, which can modulate some aspects of the host immune response. In order to evaluate the immuno-protective value of ROP54, we constructed a eukaryotic recombinant plasmid expressing T. gondii ROP54 and intramuscularly immunized Kunming mice with this recombinant plasmid against acute and chronic toxoplasmosis. All mice immunized with pVAX-ROP54 elicited a high level of specific antibody responses, a significant increase of lymphocyte proliferation, and a significant level of Th1-type cytokines (IFN-γ, IL-2 and IL-12p70), in addition to an increased production of Th2-type cytokines (IL-4 and IL-10). These results demonstrated that pVAX-ROP54 induced significant cellular and humoral (Th1/Th2) immune responses, which extended the survival time (13.0±1.15days for pVAX-ROP54 vs 6.7±0.48days for pVAX I, 6.8±0.42days for PBS and 6.5±0.53 for blank control) and significantly reduced cyst burden (35.9% for pVAX-ROP54, 1% for pVAX I and 2% for PBS, compared with blank control) of immunized mice. These results indicate that the recombinant ROP54 plasmid can provide partial protection and might be a potential vaccine candidate against acute and chronic toxoplasmosis. Copyright © 2017 Elsevier B.V. All rights reserved.

Protective immunity against Eimeria maxima induced by vaccines of Em14-3-3 antigen.

PubMed

Liu, Tingqi; Huang, Jingwei; Ehsan, Muhammad; Wang, Shuai; Fei, Hong; Zhou, Zhouyang; Song, Xiaokai; Yan, Ruofeng; Xu, Lixin; Li, Xiangrui

2018-04-15

Eimeria maxima 14-3-3 (Em14-3-3) open reading frame (ORF) which consisted of 861 bp encoding a protein of 286 amino acids was successfully amplified and sequenced. Subsequently, the Em14-3-3 ORF was subcloned into pET-32a (+) and pVAX1, respectively. RT-PCR and immunoblot analyses confirmed that the target gene was successfully transcribed and expressed in vivo. Immunofluorescence analysis showed that Em14-3-3 was expressed in both the sporozoites and merozoites. The animal experiments demonstrated that both rEm14-3-3 and pVAX1-14-3-3 could clearly alleviate jejunum lesions and body weight loss. The Em14-3-3 vaccines could increase oocyst decrease ratio, as well as produce an anticoccidial index of more than 165. The percentages of CD4 + in both the Em14-3-3 immunized groups were much higher, when compared with those of PBS, pET32a (+), and pVAX1 controls (P < 0.05). Similarly, the anti-Em14-3-3 antibody titers of both rEm14-3-3 and pVAX1-14-3-3 immunized groups showed higher levels compared with those of PBS, pET32a (+), and pVAX1 controls (P < 0.05). The IFN-γ and tumor growth factor-β (TGF-β) levels showed significant increments in the rEm14-3-3 and pVAX1-14-3-3 immunized groups, when compared with those in the negative controls (P < 0.05). These results demonstrated that Em14-3-3 could be used as a promising antigen candidate for developing vaccines against E. maxima. Copyright © 2018 Elsevier B.V. All rights reserved.

The Molecular Characterization and Immunity Identification of Rhoptry protein 22 (ROP22) of Toxoplasma gondii as a DNA Vaccine Candidate Against Toxoplasmosis.

PubMed

Zhang, Zhenchao; Li, Yuhua; Xie, Qing; Li, Pengju; Nan, Xiaoxu; Kong, Lingmin; Zeng, Dapeng; Ding, Zhifang; Wang, Shuai

2018-06-02

Toxoplasma gondii (T. gondii) rhoptry proteins (TgROPs) have been considered main targets and indicator molecules for immune diagnosis and prophylaxis since they initially present during the process of invasion. In this study, the effect of intramuscularly injecting the genetic vaccine pVAX-ROP22 was evaluated, made by inserting the TgROP22 sequence into the eukaryotic expression vector of pVAX I, into BALB/c mice. The levels of IgG, IgG1 and IgG2a in pVAX-ROP22 vaccinated animals were integrally increased. It was uncovered by cytokine profile analyses that the levels of IFN-γ and IL-2 were significantly increased, while no significant changes were detected in IL-4 and IL-10 levels. Additionally, we found that immunization with pVAX-ROP22 significantly prolonged the survival time (13.80 ± 1.75 days) of mice after challenge infection with the virulent T. gondii RH strain, in comparison to those of control animals (died within 10 days). Moreover, the number of brain cysts (1406 ± 277) in the animals subjected to pVAX-TgROP22 vaccination decreased remarkably (P < 0.05) compared to the blank control mice (2333 ± 473), and the size of brain cysts in pVAX-TgROP22 group was significantly smaller than the groups of blank, PBS and pVAXI. These results suggested that TgROP22 as DNA vaccine could trigger strong humoral and cellular responses and induce partial protection against toxoplasmosis. This article is protected by copyright. All rights reserved. This article is protected by copyright. All rights reserved.

Dermatomal somatosensory evoked potential demonstration of nerve root decompression after VAX-D therapy.

PubMed

Naguszewski, W K; Naguszewski, R K; Gose, E E

2001-10-01

Reductions in low back pain and referred leg pain associated with a diagnosis of herniated disc, degenerative disc disease or facet syndrome have previously been reported after treatment with a VAX-D table, which intermittently distracts the spine. The object of this study was to use dermatomal somatosensory evoked potentials (DSSEPs) to demonstrate lumbar root decompression following VAX-D therapy. Seven consecutive patients with a diagnosis of low back pain and unilateral or bilateral L5 or S1 radiculopathy were studied at our center. Disc herniation at the L5-S1 level was documented by MRI or CT in all patients. All patients were studied bilaterally by DSSEPs at L5 and S1 before and after VAX-D therapy. All patients had at least 50% improvement in radicular symptoms and low back pain and three of them experienced complete resolution of all symptoms. The average pain reduction was 77%. The number of treatment sessions varied from 12 to 35. DSSEPs were considered to show improvement if triphasic characteristics returned or a 50% or greater increase in the P1-P2 amplitude was seen. All patients showed improvement in DSSEPs after VAX-D therapy either ipsilateral or contralateral to the symptomatic leg. Two patients showed deterioration in DSSEPs in the symptomatic leg despite clinically significant improvement in pain and radicular symptoms. Overall, 28 nerve roots were studied before and after VAX-D therapy. Seventeen nerve root responses were improved, eight remained unchanged and three deteriorated. The significance of DSSEP improvement contralateral to the symptomatic leg is emphasized. Direct compression of a nerve root by a disc herniation is probably not the sole explanation for referred leg pain.

XRP -- SMM XRP Data Analysis & Reduction

NASA Astrophysics Data System (ADS)

McSherry, M.; Lawden, M. D.

This manual describes the various programs that are available for the reduction and analysis of XRP data. These programs have been developed under the VAX operating system. The original programs are resident on a VaxStation 3100 at the Solar Data Analysis Center (NASA/GSFC Greenbelt MD).

Substitution of wild-type yellow fever Asibi sequences for 17D vaccine sequences in ChimeriVax-dengue 4 does not enhance infection of Aedes aegypti mosquitoes.

PubMed

McGee, Charles E; Tsetsarkin, Konstantin; Vanlandingham, Dana L; McElroy, Kate L; Lang, Jean; Guy, Bruno; Decelle, Thierry; Higgs, Stephen

2008-03-01

To address concerns that a flavivirus vaccine/wild-type recombinant virus might have a high mosquito infectivity phenotype, the yellow fever virus (YFV) 17D backbone of the ChimeriVax-dengue 4 virus was replaced with the corresponding gene sequences of the virulent YFV Asibi strain. Field-collected and laboratory-colonized Aedes aegypti mosquitoes were fed on blood containing each of the viruses under investigation and held for 14 days after infection. Infection and dissemination rates were based on antigen detection in titrated body or head triturates. Our data indicate that, even in the highly unlikely event of recombination or substantial backbone reversion, virulent sequences do not enhance the transmissibility of ChimeriVax viruses. In light of the low-level viremias that have been observed after vaccination in human volunteers coupled with low mosquito infectivity, it is predicted that the risk of mosquito infection and transmission of ChimeriVax vaccine recombinant/revertant viruses in nature is minimal.

Hantavirus Gc induces long-term immune protection via LAMP-targeting DNA vaccine strategy.

PubMed

Jiang, Dong-Bo; Zhang, Jin-Peng; Cheng, Lin-Feng; Zhang, Guan-Wen; Li, Yun; Li, Zi-Chao; Lu, Zhen-Hua; Zhang, Zi-Xin; Lu, Yu-Chen; Zheng, Lian-He; Zhang, Fang-Lin; Yang, Kun

2018-02-01

Hemorrhagic fever with renal syndrome (HFRS) occurs widely throughout Eurasia. Unfortunately, there is no effective treatment, and prophylaxis remains the best option against the major pathogenic agent, hantaan virus (HTNV), which is an Old World hantavirus. However, the absence of cellular immune responses and immunological memory hampers acceptance of the current inactivated HFRS vaccine. Previous studies revealed that a lysosome-associated membrane protein 1 (LAMP1)-targeting strategy involving a DNA vaccine based on the HTNV glycoprotein Gn successfully conferred long-term immunity, and indicated that further research on Gc, another HTNV antigen, was warranted. Plasmids encoding Gc and lysosome-targeted Gc, designated pVAX-Gc and pVAX-LAMP/Gc, respectively, were constructed. Proteins of interest were identified by fluorescence microscopy following cell line transfection. Five groups of 20 female BALB/c mice were subjected to the following inoculations: inactivated HTNV vaccine, pVAX-LAMP/Gc, pVAX-Gc, and, as the negative controls, pVAX-LAMP or the blank vector pVAX1. Humoral and cellular immunity were assessed by enzyme-linked immunosorbent assays (ELISAs) and 15-mer peptide enzyme-linked immunospot (ELISpot) epitope mapping assays. Repeated immunization with pVAX-LAMP/Gc enhanced adaptive immune responses, as demonstrated by the specific and neutralizing antibody titers and increased IFN-γ production. The inactivated vaccine induced a comparable humoral reaction, but the negative controls only elicited insignificant responses. Using a mouse model of HTNV challenge, the in vivo protection conferred by the inactivated vaccine and Gc-based constructs (with/without LAMP recombination) was confirmed. Evidence of pan-epitope reactions highlighted the long-term cellular response to the LAMP-targeting strategy, and histological observations indicated the safety of the LAMP-targeting vaccines. The long-term protective immune responses induced by pVAX-LAMP/Gc may be due to the advantage afforded by lysosomal targeting after exogenous antigen processing initiation and major histocompatibility complex (MHC) class II antigen presentation trafficking. MHC II-restricted antigen recognition effectively primes HTNV-specific CD4 + T-cells, leading to the promotion of significant immune responses and immunological memory. An epitope-spreading phenomenon was observed, which mirrors the previous result from the Gn study, in which the dominant IFN-γ-responsive hot-spot epitopes were shared between HLA-II and H2 d . Importantly, the pan-epitope reaction to Gc indicated that Gc should be with potential for use in further hantavirus DNA vaccine investigations. Copyright © 2017 Elsevier B.V. All rights reserved.

Oral Vaccination with a DNA Vaccine Encoding Capsid Protein of Duck Tembusu Virus Induces Protection Immunity

PubMed Central

Shen, Haoyue; Jia, Renyong; Wang, Mingshu; Chen, Shun; Zhu, Dekang; Liu, Mafeng; Zhao, Xinxin; Yang, Qiao; Wu, Ying; Liu, Yunya; Zhang, Ling; Yin, Zhongqiong; Jing, Bo

2018-01-01

The emergence of duck tembusu virus (DTMUV), a new member of the Flavivirus genus, has caused great economical loss in the poultry industry in China. Since the outbreak and spread of DTMUV is hard to control in a clinical setting, an efficient and low-cost oral delivery DNA vaccine SL7207 (pVAX1-C) based on the capsid protein of DTMUV was developed and evaluated in this study. The antigen capsid protein was expressed from the DNA vaccine SL7207 (pVAX1-C), both in vitro and in vivo. The humoral and cellular immune responses in vivo were observed after oral immunization with the SL7207 (pVAX1-C) DNA vaccine. High titers of the specific antibody against the capsid protein and the neutralizing antibody against the DTMUV virus were both detected after inoculation. The ducks were efficiently protected from lethal DTMUV exposure by the SL7207 (pVAX1-C) vaccine in this experiment. Taken together, we demonstrated that the capsid protein of DTMUV possesses a strong immunogenicity against the DTMUV infection. Moreover, an oral delivery of the DNA vaccine SL7207 (pVAX1-C) utilizing Salmonella SL7207 was an efficient way to protect the ducks against DTMUV infection and provides an economic and fast vaccine delivery strategy for a large scale clinical use. PMID:29642401

CLIPS 6.0 - C LANGUAGE INTEGRATED PRODUCTION SYSTEM, VERSION 6.0 (DEC VAX VMS VERSION)

NASA Technical Reports Server (NTRS)

Donnell, B.

1994-01-01

CLIPS, the C Language Integrated Production System, is a complete environment for developing expert systems -- programs which are specifically intended to model human expertise or knowledge. It is designed to allow artificial intelligence research, development, and delivery on conventional computers. CLIPS 6.0 provides a cohesive tool for handling a wide variety of knowledge with support for three different programming paradigms: rule-based, object-oriented, and procedural. Rule-based programming allows knowledge to be represented as heuristics, or "rules-of-thumb" which specify a set of actions to be performed for a given situation. Object-oriented programming allows complex systems to be modeled as modular components (which can be easily reused to model other systems or create new components). The procedural programming capabilities provided by CLIPS 6.0 allow CLIPS to represent knowledge in ways similar to those allowed in languages such as C, Pascal, Ada, and LISP. Using CLIPS 6.0, one can develop expert system software using only rule-based programming, only object-oriented programming, only procedural programming, or combinations of the three. CLIPS provides extensive features to support the rule-based programming paradigm including seven conflict resolution strategies, dynamic rule priorities, and truth maintenance. CLIPS 6.0 supports more complex nesting of conditional elements in the if portion of a rule ("and", "or", and "not" conditional elements can be placed within a "not" conditional element). In addition, there is no longer a limitation on the number of multifield slots that a deftemplate can contain. The CLIPS Object-Oriented Language (COOL) provides object-oriented programming capabilities. Features supported by COOL include classes with multiple inheritance, abstraction, encapsulation, polymorphism, dynamic binding, and message passing with message-handlers. CLIPS 6.0 supports tight integration of the rule-based programming features of CLIPS with COOL (that is, a rule can pattern match on objects created using COOL). CLIPS 6.0 provides the capability to define functions, overloaded functions, and global variables interactively. In addition, CLIPS can be embedded within procedural code, called as a subroutine, and integrated with languages such as C, FORTRAN and Ada. CLIPS can be easily extended by a user through the use of several well-defined protocols. CLIPS provides several delivery options for programs including the ability to generate stand alone executables or to load programs from text or binary files. CLIPS 6.0 provides support for the modular development and execution of knowledge bases with the defmodule construct. CLIPS modules allow a set of constructs to be grouped together such that explicit control can be maintained over restricting the access of the constructs by other modules. This type of control is similar to global and local scoping used in languages such as C or Ada. By restricting access to deftemplate and defclass constructs, modules can function as blackboards, permitting only certain facts and instances to be seen by other modules. Modules are also used by rules to provide execution control. The CRSV (Cross-Reference, Style, and Verification) utility included with previous version of CLIPS is no longer supported. The capabilities provided by this tool are now available directly within CLIPS 6.0 to aid in the development, debugging, and verification of large rule bases. COSMIC offers four distribution versions of CLIPS 6.0: UNIX (MSC-22433), VMS (MSC-22434), MACINTOSH (MSC-22429), and IBM PC (MSC-22430). Executable files, source code, utilities, documentation, and examples are included on the program media. All distribution versions include identical source code for the command line version of CLIPS 6.0. This source code should compile on any platform with an ANSI C compiler. Each distribution version of CLIPS 6.0, except that for the Macintosh platform, includes an executable for the command line version. For the UNIX version of CLIPS 6.0, the command line interface has been successfully implemented on a Sun4 running SunOS, a DECstation running DEC RISC ULTRIX, an SGI Indigo Elan running IRIX, a DEC Alpha AXP running OSF/1, and an IBM RS/6000 running AIX. Command line interface executables are included for Sun4 computers running SunOS 4.1.1 or later and for the DEC RISC ULTRIX platform. The makefiles may have to be modified slightly to be used on other UNIX platforms. The UNIX, Macintosh, and IBM PC versions of CLIPS 6.0 each have a platform specific interface. Source code, a makefile, and an executable for the Windows 3.1 interface version of CLIPS 6.0 are provided only on the IBM PC distribution diskettes. Source code, a makefile, and an executable for the Macintosh interface version of CLIPS 6.0 are provided only on the Macintosh distribution diskettes. Likewise, for the UNIX version of CLIPS 6.0, only source code and a makefile for an X-Windows interface are provided. The X-Windows interface requires MIT's X Window System, Version 11, Release 4 (X11R4), the Athena Widget Set, and the Xmu library. The source code for the Athena Widget Set is provided on the distribution medium. The X-Windows interface has been successfully implemented on a Sun4 running SunOS 4.1.2 with the MIT distribution of X11R4 (not OpenWindows), an SGI Indigo Elan running IRIX 4.0.5, and a DEC Alpha AXP running OSF/1 1.2. The VAX version of CLIPS 6.0 comes only with the generic command line interface. ASCII makefiles for the command line version of CLIPS are provided on all the distribution media for UNIX, VMS, and DOS. Four executables are provided with the IBM PC version: a windowed interface executable for Windows 3.1 built using Borland C++ v3.1, an editor for use with the windowed interface, a command line version of CLIPS for Windows 3.1, and a 386 command line executable for DOS built using Zortech C++ v3.1. All four executables are capable of utilizing extended memory and require an 80386 CPU or better. Users needing an 8086/8088 or 80286 executable must recompile the CLIPS source code themselves. Users who wish to recompile the DOS executable using Borland C++ or MicroSoft C must use a DOS extender program to produce an executable capable of using extended memory. The version of CLIPS 6.0 for IBM PC compatibles requires DOS v3.3 or later and/or Windows 3.1 or later. It is distributed on a set of three 1.4Mb 3.5 inch diskettes. A hard disk is required. The Macintosh version is distributed in compressed form on two 3.5 inch 1.4Mb Macintosh format diskettes, and requires System 6.0.5, or higher, and 1Mb RAM. The version for DEC VAX/VMS is available in VAX BACKUP format on a 1600 BPI 9-track magnetic tape (standard distribution medium) or a TK50 tape cartridge. The UNIX version is distributed in UNIX tar format on a .25 inch streaming magnetic tape cartridge (Sun QIC-24). For the UNIX version, alternate distribution media and formats are available upon request. The CLIPS 6.0 documentation includes a User's Guide and a three volume Reference Manual consisting of Basic and Advanced Programming Guides and an Interfaces Guide. An electronic version of the documentation is provided on the distribution medium for each version: in MicroSoft Word format for the Macintosh and PC versions of CLIPS, and in both PostScript format and MicroSoft Word for Macintosh format for the UNIX and DEC VAX versions of CLIPS. CLIPS was developed in 1986 and Version 6.0 was released in 1993.

Complex adenovirus-vectored vaccine protects guinea pigs from three strains of Marburg virus challenges.

PubMed

Wang, Danher; Hevey, Michael; Juompan, Laure Y; Trubey, Charles M; Raja, Nicholas U; Deitz, Stephen B; Woraratanadharm, Jan; Luo, Min; Yu, Hong; Swain, Benjamin M; Moore, Kevin M; Dong, John Y

2006-09-30

The Marburg virus (MARV), an African filovirus closely related to the Ebola virus, causes a deadly hemorrhagic fever in humans, with up to 90% mortality. Currently, treatment of disease is only supportive, and no vaccines are available to prevent spread of MARV infections. In order to address this need, we have developed and characterized a novel recombinant vaccine that utilizes a single complex adenovirus-vectored vaccine (cAdVax) to overexpress a MARV glycoprotein (GP) fusion protein derived from the Musoke and Ci67 strains of MARV. Vaccination with the cAdVaxM(fus) vaccine led to efficient production of MARV-specific antibodies in both mice and guinea pigs. Significantly, guinea pigs vaccinated with at least 5 x 10(7) pfu of cAdVaxM(fus) vaccine were 100% protected against lethal challenges by the Musoke, Ci67 and Ravn strains of MARV, making it a vaccine with trivalent protective efficacy. Therefore, the cAdVaxM(fus) vaccine serves as a promising vaccine candidate to prevent and contain multi-strain infections by MARV.

Utilities for master source code distribution: MAX and Friends

NASA Technical Reports Server (NTRS)

Felippa, Carlos A.

1988-01-01

MAX is a program for the manipulation of FORTRAN master source code (MSC). This is a technique by which one maintains one and only one master copy of a FORTRAN program under a program developing system, which for MAX is assumed to be VAX/VMS. The master copy is not intended to be directly compiled. Instead it must be pre-processed by MAX to produce compilable instances. These instances may correspond to different code versions (for example, double precision versus single precision), different machines (for example, IBM, CDC, Cray) or different operating systems (i.e., VAX/VMS versus VAX/UNIX). The advantage os using a master source is more pronounced in complex application programs that are developed and maintained over many years and are to be transported and executed on several computer environments. The version lag problem that plagues many such programs is avoided by this approach. MAX is complemented by several auxiliary programs that perform nonessential functions. The ensemble is collectively known as MAX and Friends. All of these programs, including MAX, are executed as foreign VAX/VMS commands and can easily be hidden in customized VMS command procedures.

Complex adenovirus-vectored vaccine protects guinea pigs from three strains of Marburg virus challenges

DOE Office of Scientific and Technical Information (OSTI.GOV)

Wang Danher; Hevey, Michael; Juompan, Laure Y.

2006-09-30

The Marburg virus (MARV), an African filovirus closely related to the Ebola virus, causes a deadly hemorrhagic fever in humans, with up to 90% mortality. Currently, treatment of disease is only supportive, and no vaccines are available to prevent spread of MARV infections. In order to address this need, we have developed and characterized a novel recombinant vaccine that utilizes a single complex adenovirus-vectored vaccine (cAdVax) to overexpress a MARV glycoprotein (GP) fusion protein derived from the Musoke and Ci67 strains of MARV. Vaccination with the cAdVaxM(fus) vaccine led to efficient production of MARV-specific antibodies in both mice and guineamore » pigs. Significantly, guinea pigs vaccinated with at least 5 x 10{sup 7} pfu of cAdVaxM(fus) vaccine were 100% protected against lethal challenges by the Musoke, Ci67 and Ravn strains of MARV, making it a vaccine with trivalent protective efficacy. Therefore, the cAdVaxM(fus) vaccine serves as a promising vaccine candidate to prevent and contain multi-strain infections by MARV.« less

Astronauts Young and Duke study rock formations on simulated lunar traverse

NASA Technical Reports Server (NTRS)

1971-01-01

Astronauts John W. Young, right, prime crew commander for Apollo 16, and Charles M. Duke Jr., lunar module pilot, study rock formations along their simulated lunar traverse route. The prime and backup commanders and lunar module pilots for Apollo 16 took part in the two-day geology field trip and simulations in the Coso Range, near Ridgecrest, California. The training was conducted at the U.S. Naval Ordnance Test Station.

Signal Processing Expert Code (SPEC)

DOE Office of Scientific and Technical Information (OSTI.GOV)

Ames, H.S.

1985-12-01

The purpose of this paper is to describe a prototype expert system called SPEC which was developed to demonstrate the utility of providing an intelligent interface for users of SIG, a general purpose signal processing code. The expert system is written in NIL, runs on a VAX 11/750 and consists of a backward chaining inference engine and an English-like parser. The inference engine uses knowledge encoded as rules about the formats of SIG commands and about how to perform frequency analyses using SIG. The system demonstrated that expert system can be used to control existing codes.

A DNA vaccine co-expressing Trichinella spiralis MIF and MCD-1 with murine ubiquitin induces partial protective immunity in mice.

PubMed

Tang, F; Xu, L; Yan, R; Song, X; Li, X

2013-03-01

Co-expression of Trichinella spiralis macrophage migration inhibitory factor (TsMIF) with T. spiralis cystatin-like domain protein (TsMCD-1) in a DNA vaccine induces a Th1 immune response and partial protection against T. spiralis infection. The present study evaluated whether co-expression of mouse ubiquitin (Ub) with TsMIF and TsMCD-1 might improve the immune response against T. spiralis infection. Groups of BALB/c mice were immunized twice at 2-week intervals with 100 μg of plasmid DNA encoding either a TsMIF-TsMCD-1 fusion protein (pVAX1-Tsmif-Tsmcd-1) or an Ub-co-expressing triple fusion protein Ub-TsMIF-TsMCD-1 (pVAX1-Ub-Tsmif-Tsmcd-1). Control animals were immunized with pVAX1-Ub or blank vector plasmid. Specific antibody levels (IgG, IgG1, IgG2a, IgG2b, IgM, IgA, IgE) against the recombinant protein TsMIF-TsMCD-1, serum cytokines (interferon (IFN)-γ, interleukin (IL)-4, IL-5, transforming growth factor (TGF)-β1 and IL-17), CD4+/CD8+ T cells and cytotoxic T lymphocyte (CTL) responses were monitored. Challenge infection was performed 2 weeks after the second immunization and worm burden was assayed at 35 days post-challenge. Antibody responses induced by pVAX1-Ub-Tsmif-Tsmcd-1 were significantly lower than for TsMIF-TsMCD-1, but the vaccine induced increased levels of Th1 cytokine (IFN-γ) and increased T-cell cytotoxicity. The reduction of worm burden (37.95%) following immunization with pVAX1-Ub-Tsmif-Tsmcd-1 was significantly greater than that induced by the pVAX1-Tsmif-Tsmcd-1 vaccine (23.17%; P< 0.05).

TAE+ 5.1 - TRANSPORTABLE APPLICATIONS ENVIRONMENT PLUS, VERSION 5.1 (HP9000 SERIES 300/400 VERSION)

NASA Technical Reports Server (NTRS)

TAE SUPPORT OFFICE

1994-01-01

TAE (Transportable Applications Environment) Plus is an integrated, portable environment for developing and running interactive window, text, and graphical object-based application systems. The program allows both programmers and non-programmers to easily construct their own custom application interface and to move that interface and application to different machine environments. TAE Plus makes both the application and the machine environment transparent, with noticeable improvements in the learning curve. The main components of TAE Plus are as follows: (1) the WorkBench, a What You See Is What You Get (WYSIWYG) tool for the design and layout of a user interface; (2) the Window Programming Tools Package (WPT), a set of callable subroutines that control an application's user interface; and (3) TAE Command Language (TCL), an easy-to-learn command language that provides an easy way to develop an executable application prototype with a run-time interpreted language. The WorkBench tool allows the application developer to interactively construct the layout of an application's display screen by manipulating a set of interaction objects including input items such as buttons, icons, and scrolling text lists. User interface interactive objects include data-driven graphical objects such as dials, thermometers, and strip charts as well as menubars, option menus, file selection items, message items, push buttons, and color loggers. The WorkBench user specifies the windows and interaction objects that will make up the user interface, then specifies the sequence of the user interface dialogue. The description of the designed user interface is then saved into resource files. For those who desire to develop the designed user interface into an operational application, the WorkBench tool also generates source code (C, C++, Ada, and TCL) which fully controls the application's user interface through function calls to the WPTs. The WPTs are the runtime services used by application programs to display and control the user interfaces. Since the WPTs access the workbench-generated resource files during each execution, details such as color, font, location, and object type remain independent from the application code, allowing changes to the user interface without recompiling and relinking. In addition to WPTs, TAE Plus can control interaction of objects from the interpreted TAE Command Language. TCL provides a means for the more experienced developer to quickly prototype an application's use of TAE Plus interaction objects and add programming logic without the overhead of compiling or linking. TAE Plus requires MIT's X Window System, Version 11 Release 4, and the Open Software Foundation's Motif. The Workbench and WPTs are written in C++ and the remaining code is written in C. TAE Plus is available by license for an unlimited time period. The licensed program product includes the TAE Plus source code and one set of supporting documentation. Additional documentation may be purchased separately at the price indicated below. The amount of disk space required to load the TAE Plus tar format tape is between 35Mb and 67Mb depending on the machine version. The recommended minimum memory is 12Mb. Each TAE Plus platform delivery tape includes pre-built libraries and executable binary code for that particular machine, as well as source code, so users do not have to do an installation. Users wishing to recompile the source will need both a C compiler and either GNU's C++ Version 1.39 or later, or a C++ compiler based on AT&T 2.0 cfront. TAE Plus was developed in 1989 and version 5.2 was released in 1993. TAE Plus 5.2 is expected to be available on media suitable for seven different machine platforms: 1) DEC VAX computers running VMS (TK50 cartridge in VAX BACKUP format), 2) IBM RS/6000 series workstations running AIX (.25 inch tape cartridge in UNIX tar format), 3) DEC RISC workstations running ULTRIX (TK50 cartridge in UNIX tar format), 4) HP9000 Series 300/400 computers running HP-UX (.25 inch HP-preformatted tape cartridge in UNIX tar format), 5) HP9000 Series 700 computers running HP-UX (HP 4mm DDS DAT tape cartridge in UNIX tar format), 6) Sun4 (SPARC) series computers running SunOS (.25 inch tape cartridge in UNIX tar format), and 7) SGI Indigo computers running IRIX (.25 inch IRIS tape cartridge in UNIX tar format). Please contact COSMIC to obtain detailed information about the supported operating system and OSF/Motif releases required for each of these machine versions. An optional Motif Object Code License is available for the Sun4 version of TAE Plus 5.2.

Novel In Vitro/Ex Vivo Animal Modeling for Filovirus Aerosol Infection

DTIC Science & Technology

2013-09-01

CONTRACTING ORGANIZATION: Sanofi Pasteur VaxDesign Corporation Orlando, Florida, 32826...Ayesha.Mahmood@sanofi.com 5f. WORK UNIT NUMBER 7. PERFORMING ORGANIZATION NAME(S) AND ADDRESS(ES) Sanofi Pasteur VaxDesign Corporation...between the military USAMRIID labs and Sanofi Pasteur, to investigate the application of the Mucosal Tissue Equivalent (MTE) module of the MIMIC

Polling Places, Pharmacies, and Public Health: Vote & Vax 2012

PubMed Central

Moore, Ryan T.; Benson, William; Anderson, Lynda A.

2015-01-01

US national elections, which draw sizable numbers of older voters, take place during flu-shot season and represent an untapped opportunity for large-scale delivery of vaccinations. In 2012, Vote & Vax deployed a total of 1585 clinics in 48 states; Washington, DC; Guam; Puerto Rico; and the US Virgin Islands. Approximately 934 clinics were located in pharmacies, and 651 were near polling places. Polling place clinics delivered significantly more vaccines than did pharmacies (5710 vs 3669). The delivery of vaccines was estimated at 9379, and approximately 45% of the recipients identified their race/ethnicity as African American or Hispanic. More than half of the White Vote & Vax recipients and more than two thirds of the non-White recipients were not regular flu shot recipients. PMID:25879150

Polling places, pharmacies, and public health: Vote & Vax 2012.

PubMed

Shenson, Douglas; Moore, Ryan T; Benson, William; Anderson, Lynda A

2015-06-01

US national elections, which draw sizable numbers of older voters, take place during flu-shot season and represent an untapped opportunity for large-scale delivery of vaccinations. In 2012, Vote & Vax deployed a total of 1585 clinics in 48 states; Washington, DC; Guam; Puerto Rico; and the US Virgin Islands. Approximately 934 clinics were located in pharmacies, and 651 were near polling places. Polling place clinics delivered significantly more vaccines than did pharmacies (5710 vs 3669). The delivery of vaccines was estimated at 9379, and approximately 45% of the recipients identified their race/ethnicity as African American or Hispanic. More than half of the White Vote & Vax recipients and more than two thirds of the non-White recipients were not regular flu shot recipients.

Vectorization of a classical trajectory code on a floating point systems, Inc. Model 164 attached processor.

PubMed

Kraus, Wayne A; Wagner, Albert F

1986-04-01

A triatomic classical trajectory code has been modified by extensive vectorization of the algorithms to achieve much improved performance on an FPS 164 attached processor. Extensive timings on both the FPS 164 and a VAX 11/780 with floating point accelerator are presented as a function of the number of trajectories simultaneously run. The timing tests involve a potential energy surface of the LEPS variety and trajectories with 1000 time steps. The results indicate that vectorization results in timing improvements on both the VAX and the FPS. For larger numbers of trajectories run simultaneously, up to a factor of 25 improvement in speed occurs between VAX and FPS vectorized code. Copyright © 1986 John Wiley & Sons, Inc.

Analysis of ChimeriVax Japanese Encephalitis Virus envelope for T-cell epitopes and comparison to circulating strain sequences.

PubMed

De Groot, Anne S; Martin, William; Moise, Leonard; Guirakhoo, Farshad; Monath, Thomas

2007-11-19

T-cell epitope variability is associated with viral immune escape and may influence the outcome of vaccination against the highly variable Japanese Encephalitis Virus (JEV). We computationally analyzed the ChimeriVax-JEV vaccine envelope sequence for T helper epitopes that are conserved in 12 circulating JEV strains and discovered 75% conservation among putative epitopes. Among non-identical epitopes, only minor amino acid changes that would not significantly affect HLA-binding were present. Therefore, in most cases, circulating strain epitopes could be restricted by the same HLA and are likely to stimulate a cross-reactive T-cell response. Based on this analysis, we predict no significant abrogation of ChimeriVax-JEV-conferred protection against circulating JEV strains.

WORM - WINDOWED OBSERVATION OF RELATIVE MOTION

NASA Technical Reports Server (NTRS)

Bauer, F.

1994-01-01

The Windowed Observation of Relative Motion, WORM, program is primarily intended for the generation of simple X-Y plots from data created by other programs. It allows the user to label, zoom, and change the scale of various plots. Three dimensional contour and line plots are provided, although with more limited capabilities. The input data can be in binary or ASCII format, although all data must be in the same format. A great deal of control over the details of the plot is provided, such as gridding, size of tick marks, colors, log/semilog capability, time tagging, and multiple and phase plane plots. Many color and monochrome graphics terminals and hard copy printer/plotters are supported. The WORM executive commands, menu selections and macro files can be used to develop plots and tabular data, query the WORM Help library, retrieve data from input files, and invoke VAX DCL commands. WORM generated plots are displayed on local graphics terminals and can be copied using standard hard copy capabilities. Some of the graphics features of WORM include: zooming and dezooming various portions of the plot; plot documentation including curve labeling and function listing; multiple curves on the same plot; windowing of multiple plots and insets of the same plot; displaying a specific on a curve; and spinning the curve left, right, up, and down. WORM is written in PASCAL for interactive execution and has been implemented on a DEC VAX computer operating under VMS 4.7 with a virtual memory requirement of approximately 392K of 8 bit bytes. It uses the QPLOT device independent graphics library included with WORM. It was developed in 1988.

[A study on the construction, expression and immunosterility of Lagurus laguru zona pellucida 3 DNA vaccine pVAX1-sig-LTB-lZP3-C3d3].

PubMed

Li, Chen-Chen; Yu, Ji-Yun; Jiang, Min; Tu, Yi-Xian; Ma, Xiao-Lin; Zhang, Fu-Chun

2011-09-01

To enhance the immunocontraceptive effect of Lagurus lagurus zona pellucida 3 DNA vaccine, and to achieve the prospect of application through the pVAX1-sig-LTB-lZP3-C3d3 different immunity pathway. Two adjuvant molecules were constructed into the recombinant plasmid pVAX1-sig-LTB-lZP3-C3d3 as DNA vaccine which contains Escherichia coli heat-labile enterotoxin B subunit and the molecular adjuvant 3 copies of C3d. The results of RT-PCR and western blot showed that the DNA vaccine was expressed in mRNA and protein level. The female C57BL/6 mice were immunized by three ways: intramuscular injection, intranasal or oral route.Antibody levels and types were detected by ELISA. ELISA results showed that recombinant plasmid pVAX1-sig-LTB-lZP3-C3d3 immunization induced specific IgG, IgA levels were significantly different comparing with control (P<0.01). Antifertility experiment showed that the experimental group reduced the average fertility significantly different compared with the control group (P<0.01). Restriction analysis, RT-PCR and Western blot showed that the recombinant plasmid constructed correctly and can be the expression of mRNA and protein levels.It resulted that the recombinant plasmid pVAX1-sig-LTB-lZP3-C3d3 can induce the specific immune response efficiently and enhance the immunocontraceptive effects.

Parallel processing on the Livermore VAX 11/780-4 parallel processor system with compatibility to Cray Research, Inc. (CRI) multitasking. Version 1

DOE Office of Scientific and Technical Information (OSTI.GOV)

Werner, N.E.; Van Matre, S.W.

1985-05-01

This manual describes the CRI Subroutine Library and Utility Package. The CRI library provides Cray multitasking functionality on the four-processor shared memory VAX 11/780-4. Additional functionality has been added for more flexibility. A discussion of the library, utilities, error messages, and example programs is provided.

A SWOT Analysis of the Various Backup Scenarios Used in Electronic Medical Record Systems.

PubMed

Seo, Hwa Jeong; Kim, Hye Hyeon; Kim, Ju Han

2011-09-01

Electronic medical records (EMRs) are increasingly being used by health care services. Currently, if an EMR shutdown occurs, even for a moment, patient safety and care can be seriously impacted. Our goal was to determine the methodology needed to develop an effective and reliable EMR backup system. Our "independent backup system by medical organizations" paradigm implies that individual medical organizations develop their own EMR backup systems within their organizations. A "personal independent backup system" is defined as an individual privately managing his/her own medical records, whereas in a "central backup system by the government" the government controls all the data. A "central backup system by private enterprises" implies that individual companies retain control over their own data. A "cooperative backup system among medical organizations" refers to a networked system established through mutual agreement. The "backup system based on mutual trust between an individual and an organization" means that the medical information backup system at the organizational level is established through mutual trust. Through the use of SWOT analysis it can be shown that cooperative backup among medical organizations is possible to be established through a network composed of various medical agencies and that it can be managed systematically. An owner of medical information only grants data access to the specific person who gave the authorization for backup based on the mutual trust between an individual and an organization. By employing SWOT analysis, we concluded that a linkage among medical organizations or between an individual and an organization can provide an efficient backup system.

A SWOT Analysis of the Various Backup Scenarios Used in Electronic Medical Record Systems

PubMed Central

Seo, Hwa Jeong; Kim, Hye Hyeon

2011-01-01

Objectives Electronic medical records (EMRs) are increasingly being used by health care services. Currently, if an EMR shutdown occurs, even for a moment, patient safety and care can be seriously impacted. Our goal was to determine the methodology needed to develop an effective and reliable EMR backup system. Methods Our "independent backup system by medical organizations" paradigm implies that individual medical organizations develop their own EMR backup systems within their organizations. A "personal independent backup system" is defined as an individual privately managing his/her own medical records, whereas in a "central backup system by the government" the government controls all the data. A "central backup system by private enterprises" implies that individual companies retain control over their own data. A "cooperative backup system among medical organizations" refers to a networked system established through mutual agreement. The "backup system based on mutual trust between an individual and an organization" means that the medical information backup system at the organizational level is established through mutual trust. Results Through the use of SWOT analysis it can be shown that cooperative backup among medical organizations is possible to be established through a network composed of various medical agencies and that it can be managed systematically. An owner of medical information only grants data access to the specific person who gave the authorization for backup based on the mutual trust between an individual and an organization. Conclusions By employing SWOT analysis, we concluded that a linkage among medical organizations or between an individual and an organization can provide an efficient backup system. PMID:22084811

[Aviation medicine laboratory of the North Fleet air base celebrates the 70th anniversary].

PubMed

Gavrilov, V V; Mazaĭkin, D N; Buldakov, I M; Pisarev, A A

2013-05-01

The article is dedicated to the history of formation and development of the oldest aviation medicine department and its role in a flight safety of the North Fleet naval aviation. The aviation medicine laboratory was created in the years of the Great Patriotic war for medical backup of flights, medical review board, delivering of combat casualty care, prophylaxis of hypothermia and exhaustion of flight and ground crew. In a post-war period the aviation medicine laboratory made a great contribution to development of medical backup of educational and combat activity of the North Fleet aviation. Participation in cosmonaut applicants selection (incl. Yu.A. Gagarin), optimization of flight services during the transmeridian flights, research of carrier-based aircraft habitability and body state of the contingent during the longstanding ship-based aviation, development of treatment methods for functional status of sea-based aviation crew are the achievements of aviation medicine laboratory. Nowadays medicine laboratory is performing a research and practice, methodic and consultative activity with the aim of improving the system of medical backup, aviation medicine, psychology, flight safety, improvement of air crew health, prolong of flying proficiency.

Cytomegalovirus chimeric epitope vaccine supplemented with PF03512676 (CMVPepVax) in allogeneic hematopoietic stem cell transplantation: viremia, immunogenicity and survival outcomes in a randomised phase 1b trial

PubMed Central

Nakamura, Ryotaro; La Rosa, Corinna; Longmate, Jeffrey; Drake, Jennifer; Slape, Cynthia; Zhou, Qiao; Lampa, Melanie G.; O'Donnell, Margaret; Cai, Ji-Lian; Farol, Len; Salhotra, Amandeep; Snyder, David S.; Aldoss, Ibrahim; Forman, Stephen J.; Miller, Jeffrey S.; Zaia, John A.; Diamond, Don J.

2016-01-01

Summary Background Cytomegalovirus (CMV) seropositive recipients of allogeneic hematopoietic cell transplantation (HCT) are at risk for CMV reactivation. Stimulating viral immunity by vaccination may achieve CMV viremia control, without the need for antivirals. The aim of the trial is to assess safety, immunogenicity, and possible clinical benefit of CMVPepVax vaccine in HCT recipients. Methods In this randomised, open-label phase 1b trial, HCT recipients were enrolled at a single USA transplant center. Eligible patients were CMV seropositive, HLA A*0201-positive, 18–75 years, receiving HCT from matched related or unrelated donors. Patients were reassessed on day 28 post-HCT for eligibility, and 36 patients were randomised either to the vaccine (VA) or observation arm (OA), in blocks stratified by CMV donor serostatus. CMVPepVax was administered subcutaneously on days 28 and 56. CMVPepVax is a chimeric peptide composed of a cytotoxic CD8 T-cell epitope from CMV-pp65, and a tetanus T-helper epitope. It is formulated with the adjuvant PF03512676 (Pfizer Inc) a Toll-like receptor 9 agonist, which augments cellular immunity. The primary outcome was safety; secondary outcomes included immunogenicity, prevention of CMV reactivation, and clinical outcomes. Statistical analyses included all 36 randomized patients and were performed as per protocol. This study is registered as NCT01588015@www.clinicaltrials.gov. This trial is closed to accrual and a final analysis is presented in this report. Findings Between October 31, 2012, and November 5, 2014, 36 HCT recipients were randomised into the study. CMVPepVax was administered to 18 patients, with no adverse effect on HCT or rate of acute GVHD, and no unexpected adverse events. One serious adverse event (grade 1 fever) was attributed to CMVPepVax vaccination and resolved within 48 hours. Higher relapse free survival (1 versus 7 events, logrank p=0·015), a 2 fold increase in CMV-pp65 CD8 T cells during the first 100 days post-HCT (p=0·025), less CMV reactivation (1 versus 6 events, logrank p=0·039) and usage of antivirals (15 versus 263 days, p=0·03) were found in VA compared to OA recipients. Interpretation The results demonstrate safety and immunogenicity of CMVPepVax, and the prospect of significant clinical benefits that warrant testing in a phase 2 trial. PMID:26853648

Optimized construction of MUC1-VNTRn DNA vaccine and its anti-pancreatic cancer efficacy.

PubMed

Gong, Yuan-Feng; Zhou, Quan-Bo; Liao, Ya-Di; Mai, Cong; Chen, Tie-Jun; Tang, Yun-Qiang; Chen, Ru-Fu

2017-04-01

Considering mucin 1-variable number tandem repeat (MUC1-VNTR n ) as a novel target for pancreatic cancer immunotherapy, the present study aimed to screen and identify the pVAX1-MUC1-VNTR n DNA vaccine with the strongest immunogenicity. Following construction of a pVAX1-MUC1-VNTR n plasmid, immature dendritic cells (DCs) were subjected to transfection, and mature DCs were then co-cultured with autologous T-cells. The numbers of cytotoxic T lymphocytes (CTLs) secreting interferon (IFN)-γ were determined using an enzyme-linked immunospot assay, and CytoTox ® was also used to examine the MUC1-VNTR n -specific Lethal effect of CTLs on Capan2 cells. Additional in vivo experiments in mice were performed to confirm the antitumor effect of the DNA vaccine candidate. The present study successfully constructed the pVAX1-MUC1-VNTR n plasmid, which expresses the target protein in eukaryotic cells. Additionally, upon uptake of the pVAX1-MUC1-VNTR n plasmid, the immature DCs differentiated into mature DCs. The levels of the DC surface molecules cluster of differentiation (CD) 80, CD86, human leukocyte antigen-antigen D related, interleukin (IL)-12, IL-17 and IFN-γ were significantly higher, while the levels of IL-10 and IL-14 were lower, in mature DCs of the stimulated groups compared with the immature DCs of the non-stimulated groups (all P<0.01). In addition, the MUC1-VNTR 6 and MUC1-VNTR 9 groups, in which DCs were capable of activating autologous T-cells, showed increased IFN-γ-producing T-cells compared with the other groups (strong MUC1-VNTR 1 , weak VNTR 1 , VNTR 3 , VNTR 4 and MUC1-cDNA groups; all P<0.001). In addition, the Lethal effect of CTLs on Capan2 cells in these two groups was stronger compared with the other groups (all P<0.001). Furthermore, the induced protective and therapeutic immune responses in mouse experiments showed that the pVAX1-MUC1-VNTR 6 DNA vaccine likely possessed the strongest immunogenicity, and its ability to inhibit panc02-MUC1 tumor growth was superior to other DNA vaccines (P<0.01). The present study provides compelling evidence that pVAX1-MUC1-VNTR n has the potential to express the target protein in eukaryotic cells, and thatpVAX1-MUC1-VNTR 6 was characterized by the strongest Lethal effect in both in vivo and in vitro experiments.

Virtual Frame Buffer Interface Program

NASA Technical Reports Server (NTRS)

Wolfe, Thomas L.

1990-01-01

Virtual Frame Buffer Interface program makes all frame buffers appear as generic frame buffer with specified set of characteristics, allowing programmers to write codes that run unmodified on all supported hardware. Converts generic commands to actual device commands. Consists of definition of capabilities and FORTRAN subroutines called by application programs. Developed in FORTRAN 77 for DEC VAX 11/780 or DEC VAX 11/750 computer under VMS 4.X.

Implementation of RCCL, a robot control C library on a microVAX II

NASA Technical Reports Server (NTRS)

Lee, Jin S.; Hayati, Samad; Hayward, Vincent; Lloyd, John E.

1987-01-01

The robot control C library (RCCL), a high-level robot programing system which enables a progammer to employ a set of system calls to specify robot manipulator tasks, is discussed. The general structure of RCCL is described, and the implementation of RCCL on a microVAX II is examined. Proposed extensions and improvements of RCCL relevant to NASA's telerobotic system are addressed.

FEASIL Implementation under VAX VMS with Design Information.

DTIC Science & Technology

1986-11-01

desirable to eventually port FEASIL to the HP 9000, the IBM PC, and several other com- puters. However, the flowcharting and VAX conversion efforts have...v W l EU l l~rl EDIIkEL (pg 12) DEL El’F TJ-’LE C rr~PACE 13 HPvrwrH IIUpdate the I Itpe DescrL c ðere tau,1es remaining nthe relatioil ? ye

Programmer's reference manual for the VAX-Gerber link software package. Revision 1. 0

DOE Office of Scientific and Technical Information (OSTI.GOV)

Isobe, G.W.

1985-10-01

This guide provides the information necessary to edit, modify, and run the VAX-Gerber software link. Since the project is in the testing stage and still being modified, this guide discussess the final desired stage along with the current stage. The current stage is to set up as to allow the programmer to easily modify and update codes as necessary.

Cloning and Expression of Major Surface Antigen 1 Gene of Toxoplasma gondii RH Strain Using the Expression Vector pVAX1 in Chinese Hamster Ovary Cells

PubMed Central

Abdizadeh, Rahman; Maraghi, Sharif; Ghadiri, Ata A.; Tavalla, Mehdi; Shojaee, Saeedeh

2015-01-01

Background: Toxoplasmosis is an opportunistic protozoan infection with a high prevalence in a broad range of hosts infecting up to one-third of the world human population. Toxoplasmosis leads to serious medical problems in immunocompromised individuals and fetuses and also induces abortion and mortality in domestic animals. Therefore, there is a huge demand for the development of an effective vaccine. Surface Antigen 1 (SAG1) is one of the important immunodominant surface antigens of Toxoplasma gondii, which interacts with host cells and primarily involved in adhesion, invasion and stimulation of host immune response. Surface antigen 1 is considered as the leading candidate for development of an effective vaccine against toxoplasmosis. Objectives: The purpose of this study was to clone the major surface antigen1 gene (SAG1) from the genotype 1 of T. gondii, RH strain into the eukaryotic expression vector pVAX1 in order to use for a DNA vaccine. Materials and Methods: Genomic DNA was extracted from tachyzoite of the parasite using the QIAamp DNA mini kit. After designing the specific primers, SAG1 gene was amplified by Polymerase Chain Reaction (PCR). The purified PCR products were then cloned into a pPrime plasmid vector. The aforementioned product was subcloned into the pVAX1 eukaryotic expression vector. The recombinant pVAX1-SAG1 was then transfected into Chinese Hamster Ovary (CHO) cells and expression of SAG1 antigen was evaluated using Reverse Transcriptase Polymerase Chain Reaction (RT-PCR), Immunofluorescence Assay (IFA) and Western Blotting (WB). Results: The cloning and subcloning products (pPrime-SAG1 and pVAX1-SAG1 plasmid vectors) of SAG1 gene were verified and confirmed by enzyme digestion and sequencing. A 30 kDa recombinant protein was expressed in CHO cells as shown by IFA and WB methods. Conclusions: The pVAX1 expression vector and CHO cells are a suitable system for high-level recombinant protein production for SAG1 gene from T. gondii parasites and are promising approaches for antigen preparation in vaccine development. PMID:25861441

The opiorphin gene (ProL1) and its homologues function in erectile physiology.

PubMed

Tong, Yuehong; Tar, Moses; Melman, Arnold; Davies, Kelvin

2008-09-01

To determine if ProL1, a member of the opiorphin family of genes, can modulate erectile physiology, as it encodes a peptide which acts as a neutral endopeptidase inhibitor, other examples of which (Vcsa1, hSMR3A) modulate erectile physiology. We cloned members of the opiorphin family of genes into the same mammalian expression backbone (pVAX); 100 microg of these plasmids (pVAX-Vcsa1, -hSMR3A, -hSMR3B and -ProL1) were injected intracorporally into retired breeder rats and the affect on erectile physiology assessed visually, by histology and by measuring the intracavernous pressure (ICP) and blood pressure (BP). As a positive control, rats were treated with pVAX-hSlo (expressing the MaxiK potassium channel) and as a negative control the empty backbone plasmid was injected (pVAX). We also compared the level of expression of ProL1 in corporal tissue of patients not reporting erectile dysfunction (ED), ED associated with diabetes and ED not caused by diabetes. Gene transfer of plasmids expressing all members of the opiorphin family had a similar and significant effect on erectile physiology. At the concentration used in these experiments (100 microg) they resulted in higher resting ICP, and histological and visual analysis showed evidence of a priapic-like condition. After electrostimulation of the cavernous nerve, rats had significantly better ICP/BP than the negative control (pVAX). Gene transfer of pVAX-hSlo increased the ICP/BP ratio to a similar extent to the opiorphin homologues, but with no evidence for a priapic-like condition. Corpora cavernosa tissue samples obtained from men with ED, regardless of underlying causes, had significant down-regulation of both hSMR3A and ProL1. All members of the human opiorphin family of genes can potentially modulate erectile physiology. Both hSMR3 and ProL1 are down-regulated in the corpora of men with ED, and therefore both genes can potentially act as markers of ED.

The opiorphin gene (ProL1) and its homologues function in erectile physiology

PubMed Central

Tong, Yuehong; Tar, Moses; Melman, Arnold; Davies, Kelvin

2010-01-01

OBJECTIVE To determine if ProL1, a member of the opiorphin family of genes, can modulate erectile physiology, as it encodes a peptide which acts as a neutral endopeptidase inhibitor, other examples of which (Vcsa1, hSMR3A) modulate erectile physiology. MATERIALS AND METHODS We cloned members of the opiorphin family of genes into the same mammalian expression backbone (pVAX); 100 μg of these plasmids (pVAX-Vcsa1, -hSMR3A, -hSMR3B and -ProL1) were injected intracorporally into retired breeder rats and the affect on erectile physiology assessed visually, by histology and by measuring the intracavernous pressure (ICP) and blood pressure (BP). As a positive control, rats were treated with pVAX-hSlo (expressing the MaxiK potassium channel) and as a negative control the empty backbone plasmid was injected (pVAX). We also compared the level of expression of ProL1 in corporal tissue of patients not reporting erectile dysfunction (ED), ED associated with diabetes and ED not caused by diabetes. RESULTS Gene transfer of plasmids expressing all members of the opiorphin family had a similar and significant effect on erectile physiology. At the concentration used in these experiments (100 μg) they resulted in higher resting ICP, and histological and visual analysis showed evidence of a priapiclike condition. After electrostimulation of the cavernous nerve, rats had significantly better ICP/BP than the negative control (pVAX). Gene transfer of pVAX-hSlo increased the ICP/BP ratio to a similar extent to the opiorphin homologues, but with no evidence for a priapic-like condition. Corpora cavernosa tissue samples obtained from men with ED, regardless of underlying causes, had significant down-regulation of both hSMR3A and ProL1. CONCLUSION All members of the human opiorphin family of genes can potentially modulate erectile physiology. Both hSMR3 and ProL1 are down-regulated in the corpora of men with ED, and therefore both genes can potentially act as markers of ED. PMID:18410445

CAP - JET PROPULSION LABORATORY CONTAMINATION ANALYSIS PROGRAM

NASA Technical Reports Server (NTRS)

Millard, J. M.

1994-01-01

The Jet Propulsion Laboratory Contamination Analysis Program (CAP) is a generalized transient executive analysis computer code which solves realistic mass transport problems in the free molecular flow environment. These transport problems involve mass flux from surface source emission and re-emission, venting, and engine emission. CAP solution capability allows for one-bounce mass reflections if required. CAP was developed to solve thin-film contamination problems in the free molecular flow environment, the intent being to provide a powerful analytic tool for evaluating spacecraft contamination problems. The solution procedure uses an enclosure method based on a lumped-parameter multinodal approach with mass exchange between nodes. Transient solutions are computed by the finite difference Euler method. First-order rate theory is used to represent surface emission and reemission (user care must be taken to insure the problem is appropriate for such behavior), and all surface emission and reflections are assumed diffuse. CAP does not include the effects of post-deposition chemistry or interaction with the ambient atmosphere. CAP reads in a model represented by a multiple-block data stream. CAP allows the user to edit the input data stream and stack sequential editing operations (or cases) in order to make complex changes in behavior (surface temperatures, engine start-up and shut-down, etc.) in a single run if desired. The eight data blocks which make up the input data stream consist of problem control parameters, nodal data (area, temperature, mass, etc.), engine or vent distribution factors (based upon plume definitions), geometric configuration factors (diffuse surface emission), surface capture coefficient tables, source emission rate constant tables, reemission rate constant tables, and partial node to body collapse capability (for deposition rates only). The user must generate this data stream, since neither the problem-specific geometric relationships, the constituents involved, nor plume distribution functions are a part of CAP. Instead, these are used to generate the data stream model CAP solves. Outputs vary from individual deposition rates of exchange, on an internodal basis and on a constituent basis as a function of time, to deposition on each surface on a constituent basis as a function of time. The type of outputs may be user-specified by control parameters. CAP allows the user to select output intervals within the solution interval and to generate restart nodal data blocks. CAP is composed of several FORTRAN subroutines which serve specific functions and can be easily edited. The code is relatively small (2152 statements), and contains comment statements for all operations. It is written in relatively generic FORTRAN to be adaptable to a variety of computers. CAP was implemented on a DEC VAX 11/780 computer, and is distributed on a 9-track DEC VAX BACKUP format magnetic tape. Virtual memory required is 4.6 MB, which corresponds to a 900 node model capacity. CAP was originally developed under contract for NASA/Goddard Space Flight Center in 1979 by JPL, and was subsequently modified as required for project support at JPL. CAP is a copyrighted work with all copyright vested in NASA.

Eimeria maxima microneme protein 2 delivered as DNA vaccine and recombinant protein induces immunity against experimental homogenous challenge.

PubMed

Huang, Jingwei; Zhang, Zhenchao; Li, Menghui; Song, Xiaokai; Yan, Ruofeng; Xu, Lixin; Li, Xiangrui

2015-10-01

E. maxima is one of the seven species of Eimeria that infects chicken. Until now, only a few antigenic genes of E. maxima have been reported. In the present study, the immune protective effects against E. maxima challenge of recombinant protein and DNA vaccine encoding EmMIC2 were evaluated. Two-week-old chickens were randomly divided into five groups. The experimental group of chickens was immunized with 100 μg DNA vaccine pVAX1-MIC2 or 200 μg rEmMIC2 protein while the control group of chickens was injected with pVAX1 plasmid or sterile PBS. The results showed that the anti-EmMIC2 antibody titers of both rEmMIC2 protein and pVAX1-MIC2 groups were significantly higher as compared to PBS and pVAX1 control (P<0.05). The splenocytes from both vaccinated groups of chickens displayed significantly greater proliferation compared with the controls (P<0.05). Serum from chickens immunized with pVAX1-MIC2 and rEmMIC2 protein displayed significantly high levels of IL-2, IFN-γ, IL-10, IL-17, TGF-β and IL-4 (P<0.05) compared to those of negative controls. The challenge experiment results showed that both the recombinant protein and the DNA vaccine could obviously alleviate jejunum lesions, body weight loss, increase oocyst, decrease ratio and provide ACIs of more than 165. All the above results suggested that immunization with EmMIC2 was effective in imparting partial protection against E. maxima challenge and it could be an effective antigen candidate for the development of new vaccines against E. maxima. Copyright © 2015 Elsevier Ireland Ltd. All rights reserved.

LepVax, a defined subunit vaccine that provides effective pre-exposure and post-exposure prophylaxis of M. leprae infection.

PubMed

Duthie, Malcolm S; Pena, Maria T; Ebenezer, Gigi J; Gillis, Thomas P; Sharma, Rahul; Cunningham, Kelly; Polydefkis, Michael; Maeda, Yumi; Makino, Masahiko; Truman, Richard W; Reed, Steven G

2018-01-01

Sustained elimination of leprosy as a global health concern likely requires a vaccine. The current standard, BCG, confers only partial protection and precipitates paucibacillary (PB) disease in some instances. When injected into mice with the T helper 1 (Th1)-biasing adjuvant formulation Glucopyranosyl Lipid Adjuvant in stable emulsion (GLA-SE), a cocktail of three prioritized antigens (ML2055, ML2380 and ML2028) reduced M. leprae infection levels. Recognition and protective efficacy of a single chimeric fusion protein incorporating these antigens, LEP-F1, was confirmed in similar experiments. The impact of post-exposure immunization was then assessed in nine-banded armadillos that demonstrate a functional recapitulation of leprosy. Armadillos were infected with M. leprae 1 month before the initiation of post-exposure prophylaxis. While BCG precipitated motor nerve conduction abnormalities more rapidly and severely than observed for control infected armadillos, motor nerve injury in armadillos treated three times, at monthly intervals with LepVax was appreciably delayed. Biopsy of cutaneous nerves indicated that epidermal nerve fiber density was not significantly altered in M. leprae -infected animals although Remak Schwann cells of the cutaneous nerves in the distal leg were denser in the infected armadillos. Importantly, LepVax immunization did not exacerbate cutaneous nerve involvement due to M. leprae infection, indicating its safe use. There was no intraneural inflammation but a reduction of intra axonal edema suggested that LepVax treatment might restore some early sensory axonal function. These data indicate that post-exposure prophylaxis with LepVax not only appears safe but, unlike BCG, alleviates and delays the neurologic disruptions caused by M. leprae infection.

Program For Generating Interactive Displays

NASA Technical Reports Server (NTRS)

Costenbader, Jay; Moleski, Walt; Szczur, Martha; Howell, David; Engelberg, Norm; Li, Tin P.; Misra, Dharitri; Miller, Philip; Neve, Leif; Wolf, Karl;

LSENS - GENERAL CHEMICAL KINETICS AND SENSITIVITY ANALYSIS CODE

NASA Technical Reports Server (NTRS)

Bittker, D. A.

1994-01-01

LSENS has been developed for solving complex, homogeneous, gas-phase, chemical kinetics problems. The motivation for the development of this program is the continuing interest in developing detailed chemical reaction mechanisms for complex reactions such as the combustion of fuels and pollutant formation and destruction. A reaction mechanism is the set of all elementary chemical reactions that are required to describe the process of interest. Mathematical descriptions of chemical kinetics problems constitute sets of coupled, nonlinear, first-order ordinary differential equations (ODEs). The number of ODEs can be very large because of the numerous chemical species involved in the reaction mechanism. Further complicating the situation are the many simultaneous reactions needed to describe the chemical kinetics of practical fuels. For example, the mechanism describing the oxidation of the simplest hydrocarbon fuel, methane, involves over 25 species participating in nearly 100 elementary reaction steps. Validating a chemical reaction mechanism requires repetitive solutions of the governing ODEs for a variety of reaction conditions. Analytical solutions to the systems of ODEs describing chemistry are not possible, except for the simplest cases, which are of little or no practical value. Consequently, there is a need for fast and reliable numerical solution techniques for chemical kinetics problems. In addition to solving the ODEs describing chemical kinetics, it is often necessary to know what effects variations in either initial condition values or chemical reaction mechanism parameters have on the solution. Such a need arises in the development of reaction mechanisms from experimental data. The rate coefficients are often not known with great precision and in general, the experimental data are not sufficiently detailed to accurately estimate the rate coefficient parameters. The development of a reaction mechanism is facilitated by a systematic sensitivity analysis which provides the relationships between the predictions of a kinetics model and the input parameters of the problem. LSENS provides for efficient and accurate chemical kinetics computations and includes sensitivity analysis for a variety of problems, including nonisothermal conditions. LSENS replaces the previous NASA general chemical kinetics codes GCKP and GCKP84. LSENS is designed for flexibility, convenience and computational efficiency. A variety of chemical reaction models can be considered. The models include static system, steady one-dimensional inviscid flow, reaction behind an incident shock wave including boundary layer correction, and the perfectly stirred (highly backmixed) reactor. In addition, computations of equilibrium properties can be performed for the following assigned states, enthalpy and pressure, temperature and pressure, internal energy and volume, and temperature and volume. For static problems LSENS computes sensitivity coefficients with respect to the initial values of the dependent variables and/or the three rates coefficient parameters of each chemical reaction. To integrate the ODEs describing chemical kinetics problems, LSENS uses the packaged code LSODE, the Livermore Solver for Ordinary Differential Equations, because it has been shown to be the most efficient and accurate code for solving such problems. The sensitivity analysis computations use the decoupled direct method, as implemented by Dunker and modified by Radhakrishnan. This method has shown greater efficiency and stability with equal or better accuracy than other methods of sensitivity analysis. LSENS is written in FORTRAN 77 with the exception of the NAMELIST extensions used for input. While this makes the code fairly machine independent, execution times on IBM PC compatibles would be unacceptable to most users. LSENS has been successfully implemented on a Sun4 running SunOS and a DEC VAX running VMS. With minor modifications, it should also be easily implemented on other platforms with FORTRAN compilers which support NAMELIST input. LSENS required 4Mb of RAM under SunOS 4.1.1 and 3.4Mb of RAM under VMS 5.5.1. The standard distribution medium for LSENS is a .25 inch streaming magnetic tape cartridge (QIC-24) in UNIX tar format. It is also available on a 1600 BPI 9-track magnetic tape or a TK50 tape cartridge in DEC VAX BACKUP format. Alternate distribution media and formats are available upon request. LSENS was developed in 1992.

DARK Technology Transition Plan

DTIC Science & Technology

1990-04-01

or suspend/resume primitives , and bounded delays. Under the above circumstances, the extra language features, and the hidden system calls they... system , this implies that the mechanisms by which units interact - to synchronise , communicate, schedule one another, or alert one another - should be...the Kernel environment are: " The host system is a DEC VAX operating under VMS 5.0 (the specific host used at the SEI is a MicroVAX II operating under

Digital Equipment Corporation VAX/VMS Version 4.3

DTIC Science & Technology

1986-07-30

operating system performs process-oriented paging that allows execution of programs that may be larger than the physical memory allocated to them... to higher privileged modes. (For an explanation of how the four access modes provide memory access protection see page 9, "Memory Management".) A... to optimize program performance for real-time applications or interactive environments. July 30, 1986 - 4 - Final Evaluation Report Digital VAX/VMS

Novel Ricin Subunit Antigens With Enhanced Capacity to Elicit Toxin-Neutralizing Antibody Responses in Mice.

PubMed

Wahome, Newton; Sully, Erin; Singer, Christopher; Thomas, Justin C; Hu, Lei; Joshi, Sangeeta B; Volkin, David B; Fang, Jianwen; Karanicolas, John; Jacobs, Donald J; Mantis, Nicholas J; Middaugh, C Russell

2016-05-01

RiVax is a candidate ricin toxin subunit vaccine antigen that has proven to be safe in human phase I clinical trials. In this study, we introduced double and triple cavity-filling point mutations into the RiVax antigen with the expectation that stability-enhancing modifications would have a beneficial effect on overall immunogenicity of the recombinant proteins. We demonstrate that 2 RiVax triple mutant derivatives, RB (V81L/C171L/V204I) and RC (V81I/C171L/V204I), when adsorbed to aluminum salts adjuvant and tested in a mouse prime-boost-boost regimen were 5- to 10-fold more effective than RiVax at eliciting toxin-neutralizing serum IgG antibody titers. Increased toxin neutralizing antibody values and seroconversion rates were evident at different antigen dosages and within 7 days after the first booster. Quantitative stability/flexibility relationships analysis revealed that the RB and RC mutations affect rigidification of regions spanning residues 98-103, which constitutes a known immunodominant neutralizing B-cell epitope. A more detailed understanding of the immunogenic nature of RB and RC may provide insight into the fundamental relationship between local protein stability and antibody reactivity. Copyright © 2016 American Pharmacists Association®. Published by Elsevier Inc. All rights reserved.

SARA - SURE/ASSIST RELIABILITY ANALYSIS WORKSTATION (UNIX VERSION)

NASA Technical Reports Server (NTRS)

Butler, R. W.

1994-01-01

SARA, the SURE/ASSIST Reliability Analysis Workstation, is a bundle of programs used to solve reliability problems. The mathematical approach chosen to solve a reliability problem may vary with the size and nature of the problem. The Systems Validation Methods group at NASA Langley Research Center has created a set of four software packages that form the basis for a reliability analysis workstation, including three for use in analyzing reconfigurable, fault-tolerant systems and one for analyzing non-reconfigurable systems. The SARA bundle includes the three for reconfigurable, fault-tolerant systems: SURE reliability analysis program (COSMIC program LAR-13789, LAR-14921); the ASSIST specification interface program (LAR-14193, LAR-14923), and PAWS/STEM reliability analysis programs (LAR-14165, LAR-14920). As indicated by the program numbers in parentheses, each of these three packages is also available separately in two machine versions. The fourth package, which is only available separately, is FTC, the Fault Tree Compiler (LAR-14586, LAR-14922). FTC is used to calculate the top-event probability for a fault tree which describes a non-reconfigurable system. PAWS/STEM and SURE are analysis programs which utilize different solution methods, but have a common input language, the SURE language. ASSIST is a preprocessor that generates SURE language from a more abstract definition. ASSIST, SURE, and PAWS/STEM are described briefly in the following paragraphs. For additional details about the individual packages, including pricing, please refer to their respective abstracts. ASSIST, the Abstract Semi-Markov Specification Interface to the SURE Tool program, allows a reliability engineer to describe the failure behavior of a fault-tolerant computer system in an abstract, high-level language. The ASSIST program then automatically generates a corresponding semi-Markov model. A one-page ASSIST-language description may result in a semi-Markov model with thousands of states and transitions. The ASSIST program also includes model-reduction techniques to facilitate efficient modeling of large systems. The semi-Markov model generated by ASSIST is in the format needed for input to SURE and PAWS/STEM. The Semi-Markov Unreliability Range Evaluator, SURE, is an analysis tool for reconfigurable, fault-tolerant systems. SURE provides an efficient means for calculating accurate upper and lower bounds for the death state probabilities for a large class of semi-Markov models, not just those which can be reduced to critical-pair architectures. The calculated bounds are close enough (usually within 5 percent of each other) for use in reliability studies of ultra-reliable computer systems. The SURE bounding theorems have algebraic solutions and are consequently computationally efficient even for large and complex systems. SURE can optionally regard a specified parameter as a variable over a range of values, enabling an automatic sensitivity analysis. SURE output is tabular. The PAWS/STEM package includes two programs for the creation and evaluation of pure Markov models describing the behavior of fault-tolerant reconfigurable computer systems: the Pade Approximation with Scaling (PAWS) and Scaled Taylor Exponential Matrix (STEM) programs. PAWS and STEM produce exact solutions for the probability of system failure and provide a conservative estimate of the number of significant digits in the solution. Markov models of fault-tolerant architectures inevitably lead to numerically stiff differential equations. Both PAWS and STEM have the capability to solve numerically stiff models. These complementary programs use separate methods to determine the matrix exponential in the solution of the model's system of differential equations. In general, PAWS is better suited to evaluate small and dense models. STEM operates at lower precision, but works faster than PAWS for larger models. The programs that comprise the SARA package were originally developed for use on DEC VAX series computers running VMS and were later ported for use on Sun series computers running SunOS. They are written in C-language, Pascal, and FORTRAN 77. An ANSI compliant C compiler is required in order to compile the C portion of the Sun version source code. The Pascal and FORTRAN code can be compiled on Sun computers using Sun Pascal and Sun Fortran. For the VMS version, VAX C, VAX PASCAL, and VAX FORTRAN can be used to recompile the source code. The standard distribution medium for the VMS version of SARA (COS-10041) is a 9-track 1600 BPI magnetic tape in VMSINSTAL format. It is also available on a TK50 tape cartridge in VMSINSTAL format. Executables are included. The standard distribution medium for the Sun version of SARA (COS-10039) is a .25 inch streaming magnetic tape cartridge in UNIX tar format. Both Sun3 and Sun4 executables are included. Electronic copies of the ASSIST user's manual in TeX and PostScript formats are provided on the distribution medium. DEC, VAX, VMS, and TK50 are registered trademarks of Digital Equipment Corporation. Sun, Sun3, Sun4, and SunOS are trademarks of Sun Microsystems, Inc. TeX is a trademark of the American Mathematical Society. PostScript is a registered trademark of Adobe Systems Incorporated.

47 CFR 12.2 - Backup power.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 47 Telecommunication 1 2010-10-01 2010-10-01 false Backup power. 12.2 Section 12.2 Telecommunication FEDERAL COMMUNICATIONS COMMISSION GENERAL REDUNDANCY OF COMMUNICATIONS SYSTEMS § 12.2 Backup power..., must have an emergency backup power source (e.g., batteries, generators, fuel cells) for all assets...

ELAPSE - NASA AMES LISP AND ADA BENCHMARK SUITE: EFFICIENCY OF LISP AND ADA PROCESSING - A SYSTEM EVALUATION

NASA Technical Reports Server (NTRS)

Davis, G. J.

1994-01-01

One area of research of the Information Sciences Division at NASA Ames Research Center is devoted to the analysis and enhancement of processors and advanced computer architectures, specifically in support of automation and robotic systems. To compare systems' abilities to efficiently process Lisp and Ada, scientists at Ames Research Center have developed a suite of non-parallel benchmarks called ELAPSE. The benchmark suite was designed to test a single computer's efficiency as well as alternate machine comparisons on Lisp, and/or Ada languages. ELAPSE tests the efficiency with which a machine can execute the various routines in each environment. The sample routines are based on numeric and symbolic manipulations and include two-dimensional fast Fourier transformations, Cholesky decomposition and substitution, Gaussian elimination, high-level data processing, and symbol-list references. Also included is a routine based on a Bayesian classification program sorting data into optimized groups. The ELAPSE benchmarks are available for any computer with a validated Ada compiler and/or Common Lisp system. Of the 18 routines that comprise ELAPSE, provided within this package are 14 developed or translated at Ames. The others are readily available through literature. The benchmark that requires the most memory is CHOLESKY.ADA. Under VAX/VMS, CHOLESKY.ADA requires 760K of main memory. ELAPSE is available on either two 5.25 inch 360K MS-DOS format diskettes (standard distribution) or a 9-track 1600 BPI ASCII CARD IMAGE format magnetic tape. The contents of the diskettes are compressed using the PKWARE archiving tools. The utility to unarchive the files, PKUNZIP.EXE, is included. The ELAPSE benchmarks were written in 1990. VAX and VMS are trademarks of Digital Equipment Corporation. MS-DOS is a registered trademark of Microsoft Corporation.

First evidence for "The backup plan paradox".

PubMed

Napolitano, Christopher M; Freund, Alexandra M

2017-08-01

This research is a first test of the backup plan paradox. We hypothesized that investing in a backup plan may facilitate the conditions that it was developed to address: Plan A's insufficiency. Five studies provide initial, primarily correlative support for the undermining effect of investing in a backup plan. Study 1 (n= 160) demonstrated that the more participants perceived they had invested in developing a backup plan (preparing a "crib sheet"), the more likely they were to use it, although greater investments were unrelated to backup plan utility. Studies 2-4 used a simulated negotiation task. Study 2 (n = 247) demonstrated that when goal-relevant resources are limited, investing in developing backup plans and perceiving them as highly instrumental can decrease goal performance through the indirect effect of increased means replacing. Study 3 (n = 248) replicated this effect when goal-relevant resources were plentiful. Study 4 (n = 204) used an experimental variant of the simulated negotiation task and demonstrated that simply having a backup plan is not detrimental, but perceiving backup plans to be highly instrumental decreased goal performance, again through the indirect effect of increased means replacing. Study 5 (n = 160) replicated findings from Studies 1-4 using a lab-based motor task (throwing a ball). Together, these results provide first evidence that backup plans can introduce costs that may jeopardize goal performance. (PsycINFO Database Record (c) 2017 APA, all rights reserved).

Experiences running NASTRAN on the Microvax 2 computer

NASA Technical Reports Server (NTRS)

Butler, Thomas G.; Mitchell, Reginald S.

1987-01-01

The MicroVAX operates NASTRAN so well that the only detectable difference in its operation compared to an 11/780 VAX is in the execution time. On the modest installation described here, the engineer has all of the tools he needs to do an excellent job of analysis. System configuration decisions, system sizing, preparation of the system disk, definition of user quotas, installation, monitoring of system errors, and operation policies are discussed.

MIDAS - ESO's new image processing system

NASA Astrophysics Data System (ADS)

Banse, K.; Crane, P.; Grosbol, P.; Middleburg, F.; Ounnas, C.; Ponz, D.; Waldthausen, H.

1983-03-01

The Munich Image Data Analysis System (MIDAS) is an image processing system whose heart is a pair of VAX 11/780 computers linked together via DECnet. One of these computers, VAX-A, is equipped with 3.5 Mbytes of memory, 1.2 Gbytes of disk storage, and two tape drives with 800/1600 bpi density. The other computer, VAX-B, has 4.0 Mbytes of memory, 688 Mbytes of disk storage, and one tape drive with 1600/6250 bpi density. MIDAS is a command-driven system geared toward the interactive user. The type and number of parameters in a command depends on the unique parameter invoked. MIDAS is a highly modular system that provides building blocks for the undertaking of more sophisticated applications. Presently, 175 commands are available. These include the modification of the color-lookup table interactively, to enhance various image features, and the interactive extraction of subimages.

Laboratory data manipulation tools basic data handling programs. Volume 2: Detailed software/hardware documentation

NASA Technical Reports Server (NTRS)

1981-01-01

The set of computer programs described allows for data definition, data input, and data transfer between the LSI-11 microcomputers and the VAX-11/780 minicomputer. Program VAXCOM allows for a simple method of textual file transfer from the LSI to the VAX. Program LSICOM allows for easy file transfer from the VAX to the LSI. Program TTY changes the LSI-11 operators console to the LSI's printing device. Program DICTIN provides a means for defining a data set for input to either computer. Program DATAIN is a simple to operate data entry program which is capable of building data files on either machine. Program LEDITV is an extremely powerful, easy to use, line oriented text editor. Program COPYSBF is designed to print out textual files on the line printer without character loss from FORTRAN carriage control or wide record transfer.

Sleep Better at Night...Back Up Your Data.

ERIC Educational Resources Information Center

Smith, Russell

1996-01-01

Discusses the need to back up computer files, and describes the technological evolution of back-up methods. Reviews tape drive and external hard drive back-up products offered by computer companies and presents back-up strategies to use with all back-up methods. A sidebar lists information on the reviewed products. (JMV)

Gemini 8 prime and backup crews during press conference

NASA Image and Video Library

1966-02-26

S66-24380 (26 Feb. 1966) --- Gemini-8 prime and backup crews during press conference. Left to right are astronauts David R. Scott, prime crew pilot; Neil A. Armstrong, prime crew command pilot; Charles Conrad Jr., backup crew command pilot; and Richard F. Gordon Jr., backup crew pilot. Photo credit: NASA

Plasma IgG to Linear Epitopes in the V2 and V3 Regions of HIV-1 gp120 Correlate with a Reduced Risk of Infection in the RV144 Vaccine Efficacy Trial

PubMed Central

Gottardo, Raphael; Bailer, Robert T.; Korber, Bette T.; Gnanakaran, S.; Phillips, Joshua; Shen, Xiaoying; Tomaras, Georgia D.; Turk, Ellen; Imholte, Gregory; Eckler, Larry; Wenschuh, Holger; Zerweck, Johannes; Greene, Kelli; Gao, Hongmei; Berman, Phillip W.; Francis, Donald; Sinangil, Faruk; Lee, Carter; Nitayaphan, Sorachai; Rerks-Ngarm, Supachai; Kaewkungwal, Jaranit; Pitisuttithum, Punnee; Tartaglia, James; Robb, Merlin L.; Michael, Nelson L.; Kim, Jerome H.; Zolla-Pazner, Susan; Haynes, Barton F.; Mascola, John R.; Self, Steve; Gilbert, Peter; Montefiori, David C.

2013-01-01

Neutralizing and non-neutralizing antibodies to linear epitopes on HIV-1 envelope glycoproteins have potential to mediate antiviral effector functions that could be beneficial to vaccine-induced protection. Here, plasma IgG responses were assessed in three HIV-1 gp120 vaccine efficacy trials (RV144, Vax003, Vax004) and in HIV-1-infected individuals by using arrays of overlapping peptides spanning the entire consensus gp160 of all major genetic subtypes and circulating recombinant forms (CRFs) of the virus. In RV144, where 31.2% efficacy against HIV-1 infection was seen, dominant responses targeted the C1, V2, V3 and C5 regions of gp120. An analysis of RV144 case-control samples showed that IgG to V2 CRF01_AE significantly inversely correlated with infection risk (OR= 0.54, p=0.0042), as did the response to other V2 subtypes (OR=0.60-0.63, p=0.016-0.025). The response to V3 CRF01_AE also inversely correlated with infection risk but only in vaccine recipients who had lower levels of other antibodies, especially Env-specific plasma IgA (OR=0.49, p=0.007) and neutralizing antibodies (OR=0.5, p=0.008). Responses to C1 and C5 showed no significant correlation with infection risk. In Vax003 and Vax004, where no significant protection was seen, serum IgG responses targeted the same epitopes as in RV144 with the exception of an additional C1 reactivity in Vax003 and infrequent V2 reactivity in Vax004. In HIV-1 infected subjects, dominant responses targeted the V3 and C5 regions of gp120, as well as the immunodominant domain, heptad repeat 1 (HR-1) and membrane proximal external region (MPER) of gp41. These results highlight the presence of several dominant linear B cell epitopes on the HIV-1 envelope glycoproteins. They also generate the hypothesis that IgG to linear epitopes in the V2 and V3 regions of gp120 are part of a complex interplay of immune responses that contributed to protection in RV144. PMID:24086607

An Evaluation of an Ada Implementation of the Rete Algorithm for Embedded Flight Processors

DTIC Science & Technology

1990-12-01

computers was desired. The VAX VMS operating system has many built-in methods for determining program performance (including VAX PCA), but these methods... overviev , of the target environment-- the MIL-STD-1750A VHSIC Avionic Modular Processor ( VA.IP, running under the Ada Avionics Real-Time Software (AARTS... computers . Mil-STD-1750A, the Air Force’s standard flight computer architecture, however, places severe constraints on applications software processing

Ada Compiler Validation Summary Report: Certificate Number 900726W1. 11022 Verdix Corporation, VADS VAX/VMS= Intel 386, VMS 5.2, VAda-110-03315, Version 6.0, MicroVAX 3100 = iSBC 386/32

DTIC Science & Technology

1991-01-22

iSBC 386/32, bare machine Customer Agreement Number: 90-05-29- VRX See Section 3.1 for any additional information about the testing environment. As a...Defense Avail and/or Washington DC 20301 -Dist Special ----- ---- i AVF Control Number: AVF-VSR-379.0191 22 January 1991 90-05-29- VRX Ada COMPILER

Editorial

NASA Astrophysics Data System (ADS)

Murray, Jo; Lawden, Mike

1988-06-01

This will be a year of metamorphosis for Starlink with major hardware upgrades and the widespread adoption of the ADAM software environment. Most of the original VAXs will be replaced with MicroVAX 3500 based Local Area VAX Clusters (LAVCs); also disappearing from these sites will be the old ARGS as the Digisolve Ikon becomes the principal image display. This comes ten years after the idea of co-ordinating the computing activities of the UK astronomical community was first mooted. Those pre-natal days of Starlink are remembered by Professor Mike Disney in the article which follows. Many Starlink users will be surprised to learn that a centralised computing facility with only remote access or occasional visits for users was considered! (Actually the first machine, the RAL database/communictaiont MicroVAX, began operating a user service only this year.) It is instructive to look at some of the proposals for national data-analysis facilities which were forerunners of Starlink. For example, funding of £40,000 initially with £10,000 annually was requested for computer enhancements at RGO to provide a spectral reduction service. The hardware recommendation was based on a single Interdata 10 computer with a 64KByte memory and a total of 5MByte of disc! Once again, it is a pleasure to thank all the contributors to the Bulletin, and invite our readers to contribute to forthcoming editions.

Effective Protection Induced by a Monovalent DNA Vaccine against Dengue Virus (DV) Serotype 1 and a Bivalent DNA Vaccine against DV1 and DV2 in Mice.

PubMed

Zheng, Xiaoyan; Chen, Hui; Wang, Ran; Fan, Dongying; Feng, Kaihao; Gao, Na; An, Jing

2017-01-01

Dengue virus (DV) is the causal pathogen of dengue fever, which is one of the most rapidly spread mosquito-borne disease worldwide and has become a severe public health problem. Currently, there is no specific treatment for dengue; thus, a vaccine would be an effective countermeasure to reduce the morbidity and mortality. Although, the chimeric Yellow fever dengue tetravalent vaccine has been approved in some countries, it is still necessary to develop safer, more effective, and less costly vaccines. In this study, a DNA vaccine candidate pVAX1-D1ME expressing the prME protein of DV1 was inoculated in BALB/c mice via intramuscular injection or electroporation, and the immunogenicity and protection were evaluated. Compared with traditional intramuscular injection, administration with 50 μg pVAX1-D1ME via electroporation with three immunizations induced persistent humoral and cellular immune responses and effectively protected mice against lethal DV1 challenge. In addition, immunization with a bivalent vaccine consisting of pVAX1-D1ME and pVAX1-D2ME via electroporation generated a balanced IgG response and neutralizing antibodies against DV1 and DV2 and could protect mice from lethal challenge with DV1 and DV2. This study sheds new light on developing a dengue tetravalent DNA vaccine.

Effect of single-point mutations on the stability and immunogenicity of a recombinant ricin A chain subunit vaccine antigen.

PubMed

Thomas, Justin C; O'Hara, Joanne M; Hu, Lei; Gao, Fei P; Joshi, Sangeeta B; Volkin, David B; Brey, Robert N; Fang, Jianwen; Karanicolas, John; Mantis, Nicholas J; Middaugh, C Russell

2013-04-01

There is great interest in the design and development of highly thermostable and immunogenic protein subunit vaccines for biodefense. In this study, we used two orthogonal and complementary computational protein design approaches to generate a series of single-point mutants of RiVax, an attenuated recombinant ricin A chain (RTA) protein subunit vaccine antigen. As assessed by differential scanning calorimetry, the conformational stabilities of the designed mutants ranged from 4°C less stable to 4.5°C more stable than RiVax, depending on solution pH. Two more thermostable (V18P, C171L) and two less thermostable (T13V, S89T) mutants that displayed native-like secondary and tertiary structures (as determined by circular dichroism and fluorescence spectral analysis, respectively) were tested for their capacity to elicit RTA-specific antibodies and toxin-neutralizing activity. Following a prime-boost regimen, we found qualitative differences with respect to specific antibody titers and toxin neutralizing antibody levels induced by the different mutants. Upon a second boost with the more thermostable mutant C171L, a statistically significant increase in RTA-specific antibody titers was observed when compared with RiVax-immunized mice. Notably, the results indicate that single residue changes can be made to the RiVax antigen that increase its thermal stability without adversely impacting the efficacy of the vaccine.

UNIX-based data management system for the Mobile Satellite Propagation Experiment (PiFEx)

NASA Technical Reports Server (NTRS)

Kantak, Anil V.

1987-01-01

A new method is presented for handling data resulting from Mobile Satellite propagation experiments such as the Pilot Field Experiment (PiFEx) conducted by JPL. This method uses the UNIX operating system and C programming language. The data management system is implemented on a VAX minicomputer. The system automatically divides the large data file housing data from various experiments under a predetermined format into various individual files containing data from each experiment. The system also has a number of programs written in C and FORTRAN languages to allow the researcher to obtain meaningful quantities from the data at hand.

Variable coding sequence protein A1 as a marker for erectile dysfunction.

PubMed

Tong, Yuehong; Tar, Moses; Davelman, Felix; Christ, George; Melman, Arnold; Davies, Kelvin P

2006-08-01

To investigate whether variable coding sequence protein A1 (Vcsa1) is down-regulated in rat models of diabetes and ageing, and to investigate the role of Vcsa1 in erectile function, as Vcsa1 is the most down-regulated gene in the corpora of a rat model of neurogenic erectile dysfunction (ED). Quantitative reverse-transcriptase polymerase-chain reaction was used to determine Vcsa1 expression in the corpora of rats in three models of ED, i.e. streptozotocin-induced diabetes, retired breeder (old), and neurogenic (bilaterally ligated cavernosal nerves), and in control rats. To confirm a physiological role of Vcsa1 in erectile function, we carried out gene transfer studies using a plasmid in which Vcsa1 was expressed from a cytomegalovirus promoter (pVAX-Vcsa1). This plasmid was injected intracorporally into old rats, and the effect on physiology of corporal tissue was analysed by intracorporal/blood pressure (ICP/BP) measurement and histological analysis, and compared with the effects of a positive control plasmid (pVAX-hSlo, which we previously reported to restore erectile function in diabetic and ageing rats) and a negative control plasmid (pVAX). In each rat model of ED there was a significant down-regulation of the Vcsa1 transcript of at least 10-fold in corporal tissue. Remarkably, intracorporal injection with 80 microg pVAX-Vcsa1 caused priapism, as indicated by visible prolonged erection, histological appearance, and elevated resting ICP/BP. Lower doses of pVAX-Vcsa1 (5 and 25 microg) increased ICP/BP over that in untreated controls. These results show that Vcsa1 has a role in erectile function and might be a molecular marker for organic ED. The role of Vcsa1 in erectile function suggests that it could represent a novel therapeutic target for treating ED.

SATNET development and operation. Pluribus satellite IMP development. Remote site maintenance. Internet operations and maintenance. Mobile access terminal network. TCP for the HP3000. TCP-TAC. TCP for VAX-UNIX. Combined quarterly technical report

NASA Astrophysics Data System (ADS)

Bressler, R. D.

1981-11-01

This quarterly technical report describes work on the development of and experimentation with packet broadcast by satellite; on development of Pluribus Satellite IMPs; on a study of the technology of Remote Site Maintenance; on Internetwork monitoring; on shipboard satellite communications; and on the development of Transmission Control Protocols for the HP3000, TAC, and VAX-UNIX.

Design and Implementation of Software Protocol in VAX/VMS Using Ethernet Local Area Network.

DTIC Science & Technology

1983-06-01

firm hclding the trademark: INTEL Ccrporation, Santa Clara, California INTELLEC IDS Multbus DIGITAL Research, Pacific Grove, California CE/M-80...bcard NS2030 VMS device driver and N11010 diagnostic program DIGITAL Equipment Corporation, Maynard, Massachusetts V&Z-11/780 Mini computer VAX/VMS...8217 . . - - . , . editors, libary , etc.) of one node to an application process in another ncde. Such protocols may include: 1) .. 11 T f6 - allowing a process in one node to

Ada Compiler Validation Summary Report: Certificate Number: 891116W1.10194, Verdix Corporation, VADS VMS-MIL-STD-1750A, V6.0, MP, DEC MicroVAX III Host and Tektronix 1750A Emulator (Ethernet Download), v1.00-00 Target

DTIC Science & Technology

1989-11-16

VRX Ada COMPILER VALIDATION SUMMARY REPORT; Certificate Number: 891116W1.10194 Verdix Corporation VADS VMS->MIL-STD-1750A, V6.0, MP DEC MicroVAX III...1.10 Customer Agreement Number: 89-08-30- VRX This report has been reviewed and i- approved. Ada Validation Facility Steven P. Wilson Technical

Computer Language For Optimization Of Design

NASA Technical Reports Server (NTRS)

Scotti, Stephen J.; Lucas, Stephen H.

1991-01-01

SOL is computer language geared to solution of design problems. Includes mathematical modeling and logical capabilities of computer language like FORTRAN; also includes additional power of nonlinear mathematical programming methods at language level. SOL compiler takes SOL-language statements and generates equivalent FORTRAN code and system calls. Provides syntactic and semantic checking for recovery from errors and provides detailed reports containing cross-references to show where each variable used. Implemented on VAX/VMS computer systems. Requires VAX FORTRAN compiler to produce executable program.

IMAT (Integrated Multidisciplinary Analysis Tool) user's guide for the VAX/VMS computer

NASA Technical Reports Server (NTRS)

Meissner, Frances T. (Editor)

1988-01-01

The Integrated Multidisciplinary Analysis Tool (IMAT) is a computer software system for the VAX/VMS computer developed at the Langley Research Center. IMAT provides researchers and analysts with an efficient capability to analyze satellite control systems influenced by structural dynamics. Using a menu-driven executive system, IMAT leads the user through the program options. IMAT links a relational database manager to commercial and in-house structural and controls analysis codes. This paper describes the IMAT software system and how to use it.

STARLSE -- Starlink Extensions to the VAX Language Sensitive Editor

NASA Astrophysics Data System (ADS)

Warren-Smith, R. F.

STARLSE is a ``Starlink Sensitive'' editor based on the VAX Language Sensitive Editor (LSE). It exploits the extensibility of LSE to provide additional features which assist in the writing of portable Fortran 77 software with a standard Starlink style. STARLSE is intended mainly for use by those writing ADAM applications and subroutine libraries for distribution as part of the Starlink Software Collection, although it may also be suitable for other software projects. It is designed to integrate with the SST (Simple Software Tools) package.

Software For Computer-Security Audits

NASA Technical Reports Server (NTRS)

Arndt, Kate; Lonsford, Emily

1994-01-01

Information relevant to potential breaches of security gathered efficiently. Automated Auditing Tools for VAX/VMS program includes following automated software tools performing noted tasks: Privileged ID Identification, program identifies users and their privileges to circumvent existing computer security measures; Critical File Protection, critical files not properly protected identified; Inactive ID Identification, identifications of users no longer in use found; Password Lifetime Review, maximum lifetimes of passwords of all identifications determined; and Password Length Review, minimum allowed length of passwords of all identifications determined. Written in DEC VAX DCL language.

Ada Compiler Validation Summary Report: NATO SWG on APSE Compiler for VAX/VMS to MC68020 Version VCM1.82-02, VAX 8350 under VMS 5.4-1 with CAIS 5.5E Host Motorola MVME 133XT (MC68020 bare machine) Target

DTIC Science & Technology

1992-03-06

and their respective value. Macro Parameter Macro Value SACCSIZE 32 $ AL IGNMENT 4 $COUNT-LAST 2 147 483 647 SDEFAULT KMNSIZE 2147483648 $DEFAULT-STOR...The subprogram raise..exception- Azif a raises the exception -described by the information record supplied as parameter. -In addition to the subprogram

ASSIST - THE ABSTRACT SEMI-MARKOV SPECIFICATION INTERFACE TO THE SURE TOOL PROGRAM (VAX VMS VERSION)

NASA Technical Reports Server (NTRS)

Johnson, S. C.

1994-01-01

ASSIST, the Abstract Semi-Markov Specification Interface to the SURE Tool program, is an interface that will enable reliability engineers to accurately design large semi-Markov models. The user describes the failure behavior of a fault-tolerant computer system in an abstract, high-level language. The ASSIST program then automatically generates a corresponding semi-Markov model. The abstract language allows efficient description of large, complex systems; a one-page ASSIST-language description may result in a semi-Markov model with thousands of states and transitions. The ASSIST program also includes model-reduction techniques to facilitate efficient modeling of large systems. Instead of listing the individual states of the Markov model, reliability engineers can specify the rules governing the behavior of a system, and these are used to automatically generate the model. ASSIST reads an input file describing the failure behavior of a system in an abstract language and generates a Markov model in the format needed for input to SURE, the semi-Markov Unreliability Range Evaluator program, and PAWS/STEM, the Pade Approximation with Scaling program and Scaled Taylor Exponential Matrix. A Markov model consists of a number of system states and transitions between them. Each state in the model represents a possible state of the system in terms of which components have failed, which ones have been removed, etc. Within ASSIST, each state is defined by a state vector, where each element of the vector takes on an integer value within a defined range. An element can represent any meaningful characteristic, such as the number of working components of one type in the system, or the number of faulty components of another type in use. Statements representing transitions between states in the model have three parts: a condition expression, a destination expression, and a rate expression. The first expression is a Boolean expression describing the state space variable values of states for which the transition is valid. The second expression defines the destination state for the transition in terms of state space variable values. The third expression defines the distribution of elapsed time for the transition. The mathematical approach chosen to solve a reliability problem may vary with the size and nature of the problem. Although different solution techniques are utilized on different programs, it is possible to have a common input language. The Systems Validation Methods group at NASA Langley Research Center has created a set of programs that form the basis for a reliability analysis workstation. The set of programs are: SURE reliability analysis program (COSMIC program LAR-13789, LAR-14921); the ASSIST specification interface program (LAR-14193, LAR-14923), PAWS/STEM reliability analysis programs (LAR-14165, LAR-14920); and the FTC fault tree tool (LAR-14586, LAR-14922). FTC is used to calculate the top-event probability for a fault tree. PAWS/STEM and SURE are programs which interpret the same SURE language, but utilize different solution methods. ASSIST is a preprocessor that generates SURE language from a more abstract definition. SURE, ASSIST, and PAWS/STEM are also offered as a bundle. Please see the abstract for COS-10039/COS-10041, SARA - SURE/ASSIST Reliability Analysis Workstation, for pricing details. ASSIST was originally developed for DEC VAX series computers running VMS and was later ported for use on Sun computers running SunOS. The VMS version (LAR14193) is written in C-language and can be compiled with the VAX C compiler. The standard distribution medium for the VMS version of ASSIST is a 9-track 1600 BPI magnetic tape in VMSINSTAL format. It is also available on a TK50 tape cartridge in VMSINSTAL format. Executables are included. The Sun version (LAR14923) is written in ANSI C-language. An ANSI compliant C compiler is required in order to compile this package. The standard distribution medium for the Sun version of ASSIST is a .25 inch streaming magnetic tape cartridge in UNIX tar format. Both Sun3 and Sun4 executables are included. Electronic copies of the documentation in PostScript, TeX, and DVI formats are provided on the distribution medium. (The VMS distribution lacks the .DVI format files, however.) ASSIST was developed in 1986 and last updated in 1992. DEC, VAX, VMS, and TK50 are trademarks of Digital Equipment Corporation. SunOS, Sun3, and Sun4 are trademarks of Sun Microsystems, Inc. UNIX is a registered trademark of AT&T Bell Laboratories.

FTC - THE FAULT-TREE COMPILER (VAX VMS VERSION)

NASA Technical Reports Server (NTRS)

Butler, R. W.

1994-01-01

FTC, the Fault-Tree Compiler program, is a tool used to calculate the top-event probability for a fault-tree. Five different gate types are allowed in the fault tree: AND, OR, EXCLUSIVE OR, INVERT, and M OF N. The high-level input language is easy to understand and use. In addition, the program supports a hierarchical fault tree definition feature which simplifies the tree-description process and reduces execution time. A rigorous error bound is derived for the solution technique. This bound enables the program to supply an answer precisely (within the limits of double precision floating point arithmetic) at a user-specified number of digits accuracy. The program also facilitates sensitivity analysis with respect to any specified parameter of the fault tree such as a component failure rate or a specific event probability by allowing the user to vary one failure rate or the failure probability over a range of values and plot the results. The mathematical approach chosen to solve a reliability problem may vary with the size and nature of the problem. Although different solution techniques are utilized on different programs, it is possible to have a common input language. The Systems Validation Methods group at NASA Langley Research Center has created a set of programs that form the basis for a reliability analysis workstation. The set of programs are: SURE reliability analysis program (COSMIC program LAR-13789, LAR-14921); the ASSIST specification interface program (LAR-14193, LAR-14923), PAWS/STEM reliability analysis programs (LAR-14165, LAR-14920); and the FTC fault tree tool (LAR-14586, LAR-14922). FTC is used to calculate the top-event probability for a fault tree. PAWS/STEM and SURE are programs which interpret the same SURE language, but utilize different solution methods. ASSIST is a preprocessor that generates SURE language from a more abstract definition. SURE, ASSIST, and PAWS/STEM are also offered as a bundle. Please see the abstract for COS-10039/COS-10041, SARA - SURE/ASSIST Reliability Analysis Workstation, for pricing details. FTC was originally developed for DEC VAX series computers running VMS and was later ported for use on Sun computers running SunOS. The program is written in PASCAL, ANSI compliant C-language, and FORTRAN 77. The TEMPLATE graphics library is required to obtain graphical output. The standard distribution medium for the VMS version of FTC (LAR-14586) is a 9-track 1600 BPI magnetic tape in VMSINSTAL format. It is also available on a TK50 tape cartridge in VMSINSTAL format. Executables are included. The standard distribution medium for the Sun version of FTC (LAR-14922) is a .25 inch streaming magnetic tape cartridge in UNIX tar format. Both Sun3 and Sun4 executables are included. FTC was developed in 1989 and last updated in 1992. DEC, VAX, VMS, and TK50 are trademarks of Digital Equipment Corporation. UNIX is a registered trademark of AT&T Bell Laboratories. SunOS is a trademark of Sun Microsystems, Inc.

ADAMS: AIRLAB data management system user's guide

NASA Technical Reports Server (NTRS)

Conrad, C. L.; Ingogly, W. F.; Lauterbach, L. A.

1986-01-01

The AIRLAB Data Management System (ADAMS) is an online environment that supports research at NASA's AIRLAB. ADAMS provides an easy to use interactive interface that eases the task of documenting and managing information about experiments and improves communication among project members. Data managed by ADAMS includes information about experiments, data sets produced, software and hardware available in AIRLAB as well as that used in a particular experiment, and an on-line engineer's notebook. The User's Guide provides an overview of the ADAMS system as well as details of the operations available within ADAMS. A tutorial section takes the user step-by-step through a typical ADAMS session. ADAMS runs under the VAX/VMS operating system and uses the ORACLE database management system and DEC/FMS (the Forms Management System). ADAMS can be run from any VAX connected via DECnet to the ORACLE host VAX. The ADAMS system is designed for simplicity, so interactions within the underlying data management system and communications network are hidden from the user.

Q-Vax Q fever vaccine failures, Victoria, Australia 1994-2013.

PubMed

Bond, Katherine A; Franklin, Lucinda J; Sutton, Brett; Firestone, Simon M

2017-12-18

Q-Vax®, a whole cell formalin inactivated vaccine, is currently the only licensed Q fever vaccine for humans world-wide. Efficacy is high, although vaccine failures have been described for those vaccinated within the incubation of a naturally acquired infection. In Australia, it is widely used to prevent occupational acquisition of Q fever and is the mainstay for outbreak control. A retrospective review of all notified cases of acute Q fever to the Victorian department of health, 1993-2013, revealed 34 of 659 cases were previously vaccinated and 10 cases were positive on pre-vaccination screening, precluding vaccination. Twenty-one cases described high-risk exposures for C. burnetii prior to and within 15 days post vaccination and are likely to have been vaccinated within the incubation period of a natural infection. Thirteen cases described symptom onset more than 15 days post vaccination and thus may represent the first described series of Q-Vax vaccine failures following appropriate vaccination. Copyright © 2017 Elsevier Ltd. All rights reserved.

Gemini 7 backup crew seen in white room during Gemini 7 simulation activity

NASA Image and Video Library

1965-11-27

S65-61837 (27 Nov. 1965) --- The Gemini-7 backup crew seen in the White Room atop Pad 19 during Gemini-7 simulation flight activity. McDonnell Aircraft Corporation technicians assist in the exercise. Astronaut Edward H. White II (in foreground) is the Gemini-7 backup crew command pilot; and astronaut Michael Collins (right background) is the backup crew pilot. Photo credit: NASA

Apollo 16 prime and backup crewmen during geological field trip in New Mexico

NASA Image and Video Library

1971-09-09

Dr. Lee Silver (pointing foregroung), California Institute of Technology, calls a geological feature near Taos, New Mexico, to the attention of Apollo 16 prime and backup crewmen during a geological field trip. The crewmen, from left to right, are Astronauts Charles M. Duke Jr., lunar module pilot; Fred W. Haise Jr., backup commander; Edgar D. Mitchell, backup Lunar Module pilot; and John W. Young, commander.

Electroporation of a multivalent DNA vaccine cocktail elicits a protective immune response against anthrax and plague.

PubMed

Albrecht, Mark T; Livingston, Brian D; Pesce, John T; Bell, Matt G; Hannaman, Drew; Keane-Myers, Andrea M

2012-07-06

Electroporation of DNA vaccines represents a platform technology well positioned for the development of multivalent biodefense vaccines. To evaluate this hypothesis, three vaccine constructs were produced using codon-optimized genes encoding Bacillus anthracis Protective Antigen (PA), and the Yersinia pestis genes LcrV and F1, cloned into pVAX1. A/J mice were immunized on a prime-boost schedule with these constructs using the electroporation-based TriGrid Delivery System. Immunization with the individual pDNA vaccines elicited higher levels of antigen-specific IgG than when used in combination. DNA vaccine effectiveness was proven, the pVAX-PA titers were toxin neutralizing and fully protective against a lethal B. anthracis spore challenge when administered alone or co-formulated with the plague pDNA vaccines. LcrV and F1 pVAX vaccines against plague were synergistic, resulting in 100% survival, but less protective individually and when co-formulated with pVAX-PA. These DNA vaccine responses were Th1/Th2 balanced with high levels of IFN-γ and IL-4 in splenocyte recall assays, contrary to complimentary protein Alum vaccinations displaying a Th2 bias with increased IL-4 and low levels of IFN-γ. These results demonstrate the feasibility of electroporation to deliver and maintain the overall efficacy of an anthrax-plague DNA vaccine cocktail whose individual components have qualitative immunological differences when combined. Published by Elsevier Ltd.

Birth control pills - progestin only

MedlinePlus

... pregnant right away. When to Use a Backup Method Use a backup method of birth control, such as a condom, diaphragm, ... body may not absorb it. Use a backup method of birth control, and call your provider. You ...

Birth control pills - combination

MedlinePlus

... or mood swings. When to Use a Backup Method Use a backup method of birth control, such as condom, diaphragm, or ... body may not absorb it. Use a backup method of birth control for the rest of that ...

Backup agreements with penalty scheme under supply disruptions

NASA Astrophysics Data System (ADS)

Hou, Jing; Zhao, Lindu

2012-05-01

This article considers a supply chain for a single product involving one retailer and two independent suppliers, when the main supplier might fail to supply the products, the backup supplier can always supply the products at a higher price. The retailer could use the backup supplier as a regular provider or a stand-by source by reserving some products at the supplier. A backup agreement with penalty scheme is constructed between the retailer and the backup supplier to mitigate the supply disruptions and the demand uncertainty. The expected profit functions and the optimal decisions of the two players are derived through a sequential optimisation process. Then, the sensitivity of two players' expected profits to various input factors is examined through numerical examples. The impacts of the disruption probability and the demand uncertainty on the backup agreement are also investigated, which could provide guideline for how to use each sourcing method.

PLOT3D/AMES, DEC VAX VMS VERSION USING DISSPLA (WITHOUT TURB3D)

NASA Technical Reports Server (NTRS)

Buning, P. G.

1994-01-01

PLOT3D is an interactive graphics program designed to help scientists visualize computational fluid dynamics (CFD) grids and solutions. Today, supercomputers and CFD algorithms can provide scientists with simulations of such highly complex phenomena that obtaining an understanding of the simulations has become a major problem. Tools which help the scientist visualize the simulations can be of tremendous aid. PLOT3D/AMES offers more functions and features, and has been adapted for more types of computers than any other CFD graphics program. Version 3.6b+ is supported for five computers and graphic libraries. Using PLOT3D, CFD physicists can view their computational models from any angle, observing the physics of problems and the quality of solutions. As an aid in designing aircraft, for example, PLOT3D's interactive computer graphics can show vortices, temperature, reverse flow, pressure, and dozens of other characteristics of air flow during flight. As critical areas become obvious, they can easily be studied more closely using a finer grid. PLOT3D is part of a computational fluid dynamics software cycle. First, a program such as 3DGRAPE (ARC-12620) helps the scientist generate computational grids to model an object and its surrounding space. Once the grids have been designed and parameters such as the angle of attack, Mach number, and Reynolds number have been specified, a "flow-solver" program such as INS3D (ARC-11794 or COS-10019) solves the system of equations governing fluid flow, usually on a supercomputer. Grids sometimes have as many as two million points, and the "flow-solver" produces a solution file which contains density, x- y- and z-momentum, and stagnation energy for each grid point. With such a solution file and a grid file containing up to 50 grids as input, PLOT3D can calculate and graphically display any one of 74 functions, including shock waves, surface pressure, velocity vectors, and particle traces. PLOT3D's 74 functions are organized into five groups: 1) Grid Functions for grids, grid-checking, etc.; 2) Scalar Functions for contour or carpet plots of density, pressure, temperature, Mach number, vorticity magnitude, helicity, etc.; 3) Vector Functions for vector plots of velocity, vorticity, momentum, and density gradient, etc.; 4) Particle Trace Functions for rake-like plots of particle flow or vortex lines; and 5) Shock locations based on pressure gradient. TURB3D is a modification of PLOT3D which is used for viewing CFD simulations of incompressible turbulent flow. Input flow data consists of pressure, velocity and vorticity. Typical quantities to plot include local fluctuations in flow quantities and turbulent production terms, plotted in physical or wall units. PLOT3D/TURB3D includes both TURB3D and PLOT3D because the operation of TURB3D is identical to PLOT3D, and there is no additional sample data or printed documentation for TURB3D. Graphical capabilities of PLOT3D version 3.6b+ vary among the implementations available through COSMIC. Customers are encouraged to purchase and carefully review the PLOT3D manual before ordering the program for a specific computer and graphics library. There is only one manual for use with all implementations of PLOT3D, and although this manual generally assumes that the Silicon Graphics Iris implementation is being used, informative comments concerning other implementations appear throughout the text. With all implementations, the visual representation of the object and flow field created by PLOT3D consists of points, lines, and polygons. Points can be represented with dots or symbols, color can be used to denote data values, and perspective is used to show depth. Differences among implementations impact the program's ability to use graphical features that are based on 3D polygons, the user's ability to manipulate the graphical displays, and the user's ability to obtain alternate forms of output. The VAX/VMS/DISSPLA implementation of PLOT3D supports 2-D polygons as well as 2-D and 3-D lines, but does not support graphics features requiring 3-D polygons (shading and hidden line removal, for example). Views can be manipulated using keyboard commands. This version of PLOT3D is potentially able to produce files for a variety of output devices; however, site-specific capabilities will vary depending on the device drivers supplied with the user's DISSPLA library. If ARCGRAPH (ARC-12350) is installed on the user's VAX, the VMS/DISSPLA version of PLOT3D can also be used to create files for use in GAS (Graphics Animation System, ARC-12379), an IRIS program capable of animating and recording images on film. The version 3.6b+ VMS/DISSPLA implementations of PLOT3D (ARC-12777) and PLOT3D/TURB3D (ARC-12781) were developed for use on VAX computers running VMS Version 5.0 and DISSPLA Version 11.0. The standard distribution media for each of these programs is a 9-track, 6250 bpi magnetic tape in DEC VAX BACKUP format. Customers purchasing one implementation version of PLOT3D or PLOT3D/TURB3D will be given a $200 discount on each additional implementation version ordered at the same time. Version 3.6b+ of PLOT3D and PLOT3D/TURB3D are also supported for the following computers and graphics libraries: (1) generic UNIX Supercomputer and IRIS, suitable for CRAY 2/UNICOS, CONVEX, and Alliant with remote IRIS 2xxx/3xxx or IRIS 4D (ARC-12779, ARC-12784); (2) Silicon Graphics IRIS 2xxx/3xxx or IRIS 4D (ARC-12783, ARC12782); (3) generic UNIX and DISSPLA Version 11.0 (ARC-12788, ARC-12778); and (4) Apollo computers running UNIX and GMR3D Version 2.0 (ARC-12789, ARC-12785 which have no capabilities to put text on plots). Silicon Graphics Iris, IRIS 4D, and IRIS 2xxx/3xxx are trademarks of Silicon Graphics Incorporated. VAX and VMS are trademarks of Digital Electronics Corporation. DISSPLA is a trademark of Computer Associates. CRAY 2 and UNICOS are trademarks of CRAY Research, Incorporated. CONVEX is a trademark of Convex Computer Corporation. Alliant is a trademark of Alliant. Apollo and GMR3D are trademarks of Hewlett-Packard, Incorporated. UNIX is a registered trademark of AT&T.

PLOT3D/AMES, DEC VAX VMS VERSION USING DISSPLA (WITH TURB3D)

NASA Technical Reports Server (NTRS)

Buning, P.

1994-01-01

PLOT3D is an interactive graphics program designed to help scientists visualize computational fluid dynamics (CFD) grids and solutions. Today, supercomputers and CFD algorithms can provide scientists with simulations of such highly complex phenomena that obtaining an understanding of the simulations has become a major problem. Tools which help the scientist visualize the simulations can be of tremendous aid. PLOT3D/AMES offers more functions and features, and has been adapted for more types of computers than any other CFD graphics program. Version 3.6b+ is supported for five computers and graphic libraries. Using PLOT3D, CFD physicists can view their computational models from any angle, observing the physics of problems and the quality of solutions. As an aid in designing aircraft, for example, PLOT3D's interactive computer graphics can show vortices, temperature, reverse flow, pressure, and dozens of other characteristics of air flow during flight. As critical areas become obvious, they can easily be studied more closely using a finer grid. PLOT3D is part of a computational fluid dynamics software cycle. First, a program such as 3DGRAPE (ARC-12620) helps the scientist generate computational grids to model an object and its surrounding space. Once the grids have been designed and parameters such as the angle of attack, Mach number, and Reynolds number have been specified, a "flow-solver" program such as INS3D (ARC-11794 or COS-10019) solves the system of equations governing fluid flow, usually on a supercomputer. Grids sometimes have as many as two million points, and the "flow-solver" produces a solution file which contains density, x- y- and z-momentum, and stagnation energy for each grid point. With such a solution file and a grid file containing up to 50 grids as input, PLOT3D can calculate and graphically display any one of 74 functions, including shock waves, surface pressure, velocity vectors, and particle traces. PLOT3D's 74 functions are organized into five groups: 1) Grid Functions for grids, grid-checking, etc.; 2) Scalar Functions for contour or carpet plots of density, pressure, temperature, Mach number, vorticity magnitude, helicity, etc.; 3) Vector Functions for vector plots of velocity, vorticity, momentum, and density gradient, etc.; 4) Particle Trace Functions for rake-like plots of particle flow or vortex lines; and 5) Shock locations based on pressure gradient. TURB3D is a modification of PLOT3D which is used for viewing CFD simulations of incompressible turbulent flow. Input flow data consists of pressure, velocity and vorticity. Typical quantities to plot include local fluctuations in flow quantities and turbulent production terms, plotted in physical or wall units. PLOT3D/TURB3D includes both TURB3D and PLOT3D because the operation of TURB3D is identical to PLOT3D, and there is no additional sample data or printed documentation for TURB3D. Graphical capabilities of PLOT3D version 3.6b+ vary among the implementations available through COSMIC. Customers are encouraged to purchase and carefully review the PLOT3D manual before ordering the program for a specific computer and graphics library. There is only one manual for use with all implementations of PLOT3D, and although this manual generally assumes that the Silicon Graphics Iris implementation is being used, informative comments concerning other implementations appear throughout the text. With all implementations, the visual representation of the object and flow field created by PLOT3D consists of points, lines, and polygons. Points can be represented with dots or symbols, color can be used to denote data values, and perspective is used to show depth. Differences among implementations impact the program's ability to use graphical features that are based on 3D polygons, the user's ability to manipulate the graphical displays, and the user's ability to obtain alternate forms of output. The VAX/VMS/DISSPLA implementation of PLOT3D supports 2-D polygons as well as 2-D and 3-D lines, but does not support graphics features requiring 3-D polygons (shading and hidden line removal, for example). Views can be manipulated using keyboard commands. This version of PLOT3D is potentially able to produce files for a variety of output devices; however, site-specific capabilities will vary depending on the device drivers supplied with the user's DISSPLA library. If ARCGRAPH (ARC-12350) is installed on the user's VAX, the VMS/DISSPLA version of PLOT3D can also be used to create files for use in GAS (Graphics Animation System, ARC-12379), an IRIS program capable of animating and recording images on film. The version 3.6b+ VMS/DISSPLA implementations of PLOT3D (ARC-12777) and PLOT3D/TURB3D (ARC-12781) were developed for use on VAX computers running VMS Version 5.0 and DISSPLA Version 11.0. The standard distribution media for each of these programs is a 9-track, 6250 bpi magnetic tape in DEC VAX BACKUP format. Customers purchasing one implementation version of PLOT3D or PLOT3D/TURB3D will be given a $200 discount on each additional implementation version ordered at the same time. Version 3.6b+ of PLOT3D and PLOT3D/TURB3D are also supported for the following computers and graphics libraries: (1) generic UNIX Supercomputer and IRIS, suitable for CRAY 2/UNICOS, CONVEX, and Alliant with remote IRIS 2xxx/3xxx or IRIS 4D (ARC-12779, ARC-12784); (2) Silicon Graphics IRIS 2xxx/3xxx or IRIS 4D (ARC-12783, ARC12782); (3) generic UNIX and DISSPLA Version 11.0 (ARC-12788, ARC-12778); and (4) Apollo computers running UNIX and GMR3D Version 2.0 (ARC-12789, ARC-12785 which have no capabilities to put text on plots). Silicon Graphics Iris, IRIS 4D, and IRIS 2xxx/3xxx are trademarks of Silicon Graphics Incorporated. VAX and VMS are trademarks of Digital Electronics Corporation. DISSPLA is a trademark of Computer Associates. CRAY 2 and UNICOS are trademarks of CRAY Research, Incorporated. CONVEX is a trademark of Convex Computer Corporation. Alliant is a trademark of Alliant. Apollo and GMR3D are trademarks of Hewlett-Packard, Incorporated. UNIX is a registered trademark of AT&T.

A keyboard control method for loop measurement

DOE Office of Scientific and Technical Information (OSTI.GOV)

Gao, Z.W.

1994-12-31

This paper describes a keyboard control mode based on the DEC VAX computer. The VAX Keyboard code can be found under running of a program was developed. During the loop measurement or multitask operation, it ables to be distinguished from a keyboard code to stop current operation or transfer to another operation while previous information can be held. The combining of this mode, the author successfully used one key control loop measurement for test Dual Input Memory module which is used in a rearrange Energy Trigger system for LEP 8 Bunch operation.

Multimission Modular Spacecraft Ground Support Software System (MMS/GSSS) state-of-the-art computer systems/ compatibility study

NASA Technical Reports Server (NTRS)

1980-01-01

The compatibility of the Multimission Modular Spacecraft (MMS) Ground Support Software System (GSSS), currently operational on a ModComp IV/35, with the VAX 11/780 system is discussed. The compatibility is examined in various key areas of the GSSS through the results of in depth testing performed on the VAX 11/780 and ModComp IV/35 systems. The compatibility of the GSSS with the ModComp CLASSIC is presented based upon projections from ModComp supplied literature.

Software and Hardware Description of the Helicopter Motion Equations for VAX Computers

DTIC Science & Technology

1989-08-01

17. COSATI CODES 18 SUBJECT TERMS (Continue on reverse if r:".essary and identify by block number) FIELD GROUP SUB-GROUP human engineering flight eq...global section’s name is HACSEC. d. The name of the disk file opened to map the pages is HACSEC.DAT. VAX FORTRAN common statements are used in all...MOZ(1O) INTEGER*2 ATYPE(10) INTECER*2 AGAT( 10) INTEGER*2 AGRQUP(10) REAL*4 MOUC 10) REAL*4 MOHEAD(10) REAL*4 MOPHI(10) REAL*4 MOTHET(10) GOMMO4N

All Source Analysis System (ASAS): Migration from VAX to Alpha AXP computer systems

NASA Technical Reports Server (NTRS)

Sjoholm-Sierchio, Michael J.; Friedman, Steven Z. (Editor)

1994-01-01

The Jet Propulsion Laboratory's (JPL's) experience migrating existing VAX applications to Digital Equipment Corporation's new Alpha AXP processor is covered. The rapid development approach used during the 10-month period required to migrate the All Source Analysis System (ASAS), 1.5 million lines of FORTRAN, C, and Ada code, is also covered. ASAS, an automated tactical intelligence system, was developed by the Jet Propulsion Laboratory for the U. S. Army. Other benefits achieved as a result of the significant performance improvements provided by Alpha AXP platform are also described.

Multiplexing the Ethernet Interface Among VAX/VMS Users.

DTIC Science & Technology

1983-12-01

Microcomputer Development Systems (MDS) and VAX/VPS sy’stemn were used for the implementation and testing of the project. The software is designed in such a...detailed design and .splesenta- toa of tie project. Is realLty chape: I constitutes the doee-.at os of the developed software. In soms instances, thisgs that...changes. 460i9n4t 4 provides a high level design of a virtual x $44 aletwock. alcag with some hints which may be useful So 44e W". who will work in this

STS-47 crew and backups at MSFC's Payload Crew Training Complex

NASA Technical Reports Server (NTRS)

1992-01-01

STS-47 Endeavour, Orbiter Vehicle (OV) 105, Spacelab Japan (SLJ) crewmembers and backup payload specialists stand outside SLJ module mockup at the Payload Crew Training Complex at Marshall SpaceFlight Center (MSFC) in Huntsville, Alabama. From left to right are Payload Specialist Mamoru Mohri, backup Payload Specialist Takao Doi, backup Payload Specialist Chiaki Naito-Mukai, Mission Specialist (MS) Mae C. Jemison, MS N. Jan Davis, backup Payload Specialist Stan Koszelak, and MS and Payload Commander (PLC) Mark C. Lee. The MSFC-managed mission is a joint venture in space-based research between the United States and Japan. Mohri, Doi, and Mukai represent Japan's National Space Development Agency (NASDA). View provided with alternate number 92P-142.

[Positional accuracy and quality assurance of Backup JAWs required for volumetric modulated arc therapy].

PubMed

Tatsumi, Daisaku; Nakada, Ryosei; Ienaga, Akinori; Yomoda, Akane; Inoue, Makoto; Ichida, Takao; Hosono, Masako

2012-01-01

The tolerance of the Backup diaphragm (Backup JAW) setting in Elekta linac was specified as 2 mm according to the AAPM TG-142 report. However, the tolerance and the quality assurance procedure for volumetric modulated arc therapy (VMAT) was not provided. This paper describes positional accuracy and quality assurance procedure of the Backup JAWs required for VMAT. It was found that a gap-width error of the Backup JAW by a sliding window test needed to be less than 1.5 mm for prostate VMAT delivery. It was also confirmed that the gap-widths had been maintained with an error of 0.2 mm during the past one year.

Hydrogen Fuel Cell Performance as Telecommunications Backup Power in the United States

DOE Office of Scientific and Technical Information (OSTI.GOV)

Kurtz, Jennifer; Saur, Genevieve; Sprik, Sam

2015-03-01

Working in collaboration with the U.S. Department of Energy (DOE) and industry project partners, the National Renewable Energy Laboratory (NREL) acts as the central data repository for the data collected from real-world operation of fuel cell backup power systems. With American Recovery and Reinvestment Act of 2009 (ARRA) co-funding awarded through DOE's Fuel Cell Technologies Office, more than 1,300 fuel cell units were deployed over a three-plus-year period in stationary, material handling equipment, auxiliary power, and backup power applications. This surpassed a Fuel Cell Technologies Office ARRA objective to spur commercialization of an early market technology by installing 1,000 fuelmore » cell units across several different applications, including backup power. By December 2013, 852 backup power units out of 1,330 fuel cell units deployed were providing backup service, mainly for telecommunications towers. For 136 of the fuel cell backup units, project participants provided detailed operational data to the National Fuel Cell Technology Evaluation Center for analysis by NREL's technology validation team. NREL analyzed operational data collected from these government co-funded demonstration projects to characterize key fuel cell backup power performance metrics, including reliability and operation trends, and to highlight the business case for using fuel cells in these early market applications. NREL's analyses include these critical metrics, along with deployment, U.S. grid outage statistics, and infrastructure operation.« less

CLIPS 6.0 - C LANGUAGE INTEGRATED PRODUCTION SYSTEM, VERSION 6.0 (UNIX VERSION)

NASA Technical Reports Server (NTRS)

Donnell, B.

1994-01-01

CLIPS, the C Language Integrated Production System, is a complete environment for developing expert systems -- programs which are specifically intended to model human expertise or knowledge. It is designed to allow artificial intelligence research, development, and delivery on conventional computers. CLIPS 6.0 provides a cohesive tool for handling a wide variety of knowledge with support for three different programming paradigms: rule-based, object-oriented, and procedural. Rule-based programming allows knowledge to be represented as heuristics, or "rules-of-thumb" which specify a set of actions to be performed for a given situation. Object-oriented programming allows complex systems to be modeled as modular components (which can be easily reused to model other systems or create new components). The procedural programming capabilities provided by CLIPS 6.0 allow CLIPS to represent knowledge in ways similar to those allowed in languages such as C, Pascal, Ada, and LISP. Using CLIPS 6.0, one can develop expert system software using only rule-based programming, only object-oriented programming, only procedural programming, or combinations of the three. CLIPS provides extensive features to support the rule-based programming paradigm including seven conflict resolution strategies, dynamic rule priorities, and truth maintenance. CLIPS 6.0 supports more complex nesting of conditional elements in the if portion of a rule ("and", "or", and "not" conditional elements can be placed within a "not" conditional element). In addition, there is no longer a limitation on the number of multifield slots that a deftemplate can contain. The CLIPS Object-Oriented Language (COOL) provides object-oriented programming capabilities. Features supported by COOL include classes with multiple inheritance, abstraction, encapsulation, polymorphism, dynamic binding, and message passing with message-handlers. CLIPS 6.0 supports tight integration of the rule-based programming features of CLIPS with COOL (that is, a rule can pattern match on objects created using COOL). CLIPS 6.0 provides the capability to define functions, overloaded functions, and global variables interactively. In addition, CLIPS can be embedded within procedural code, called as a subroutine, and integrated with languages such as C, FORTRAN and Ada. CLIPS can be easily extended by a user through the use of several well-defined protocols. CLIPS provides several delivery options for programs including the ability to generate stand alone executables or to load programs from text or binary files. CLIPS 6.0 provides support for the modular development and execution of knowledge bases with the defmodule construct. CLIPS modules allow a set of constructs to be grouped together such that explicit control can be maintained over restricting the access of the constructs by other modules. This type of control is similar to global and local scoping used in languages such as C or Ada. By restricting access to deftemplate and defclass constructs, modules can function as blackboards, permitting only certain facts and instances to be seen by other modules. Modules are also used by rules to provide execution control. The CRSV (Cross-Reference, Style, and Verification) utility included with previous version of CLIPS is no longer supported. The capabilities provided by this tool are now available directly within CLIPS 6.0 to aid in the development, debugging, and verification of large rule bases. COSMIC offers four distribution versions of CLIPS 6.0: UNIX (MSC-22433), VMS (MSC-22434), MACINTOSH (MSC-22429), and IBM PC (MSC-22430). Executable files, source code, utilities, documentation, and examples are included on the program media. All distribution versions include identical source code for the command line version of CLIPS 6.0. This source code should compile on any platform with an ANSI C compiler. Each distribution version of CLIPS 6.0, except that for the Macintosh platform, includes an executable for the command line version. For the UNIX version of CLIPS 6.0, the command line interface has been successfully implemented on a Sun4 running SunOS, a DECstation running DEC RISC ULTRIX, an SGI Indigo Elan running IRIX, a DEC Alpha AXP running OSF/1, and an IBM RS/6000 running AIX. Command line interface executables are included for Sun4 computers running SunOS 4.1.1 or later and for the DEC RISC ULTRIX platform. The makefiles may have to be modified slightly to be used on other UNIX platforms. The UNIX, Macintosh, and IBM PC versions of CLIPS 6.0 each have a platform specific interface. Source code, a makefile, and an executable for the Windows 3.1 interface version of CLIPS 6.0 are provided only on the IBM PC distribution diskettes. Source code, a makefile, and an executable for the Macintosh interface version of CLIPS 6.0 are provided only on the Macintosh distribution diskettes. Likewise, for the UNIX version of CLIPS 6.0, only source code and a makefile for an X-Windows interface are provided. The X-Windows interface requires MIT's X Window System, Version 11, Release 4 (X11R4), the Athena Widget Set, and the Xmu library. The source code for the Athena Widget Set is provided on the distribution medium. The X-Windows interface has been successfully implemented on a Sun4 running SunOS 4.1.2 with the MIT distribution of X11R4 (not OpenWindows), an SGI Indigo Elan running IRIX 4.0.5, and a DEC Alpha AXP running OSF/1 1.2. The VAX version of CLIPS 6.0 comes only with the generic command line interface. ASCII makefiles for the command line version of CLIPS are provided on all the distribution media for UNIX, VMS, and DOS. Four executables are provided with the IBM PC version: a windowed interface executable for Windows 3.1 built using Borland C++ v3.1, an editor for use with the windowed interface, a command line version of CLIPS for Windows 3.1, and a 386 command line executable for DOS built using Zortech C++ v3.1. All four executables are capable of utilizing extended memory and require an 80386 CPU or better. Users needing an 8086/8088 or 80286 executable must recompile the CLIPS source code themselves. Users who wish to recompile the DOS executable using Borland C++ or MicroSoft C must use a DOS extender program to produce an executable capable of using extended memory. The version of CLIPS 6.0 for IBM PC compatibles requires DOS v3.3 or later and/or Windows 3.1 or later. It is distributed on a set of three 1.4Mb 3.5 inch diskettes. A hard disk is required. The Macintosh version is distributed in compressed form on two 3.5 inch 1.4Mb Macintosh format diskettes, and requires System 6.0.5, or higher, and 1Mb RAM. The version for DEC VAX/VMS is available in VAX BACKUP format on a 1600 BPI 9-track magnetic tape (standard distribution medium) or a TK50 tape cartridge. The UNIX version is distributed in UNIX tar format on a .25 inch streaming magnetic tape cartridge (Sun QIC-24). For the UNIX version, alternate distribution media and formats are available upon request. The CLIPS 6.0 documentation includes a User's Guide and a three volume Reference Manual consisting of Basic and Advanced Programming Guides and an Interfaces Guide. An electronic version of the documentation is provided on the distribution medium for each version: in MicroSoft Word format for the Macintosh and PC versions of CLIPS, and in both PostScript format and MicroSoft Word for Macintosh format for the UNIX and DEC VAX versions of CLIPS. CLIPS was developed in 1986 and Version 6.0 was released in 1993.

CLIPS 6.0 - C LANGUAGE INTEGRATED PRODUCTION SYSTEM, VERSION 6.0 (IBM PC VERSION)

NASA Technical Reports Server (NTRS)

Donnell, B.

1994-01-01

CLIPS, the C Language Integrated Production System, is a complete environment for developing expert systems -- programs which are specifically intended to model human expertise or knowledge. It is designed to allow artificial intelligence research, development, and delivery on conventional computers. CLIPS 6.0 provides a cohesive tool for handling a wide variety of knowledge with support for three different programming paradigms: rule-based, object-oriented, and procedural. Rule-based programming allows knowledge to be represented as heuristics, or "rules-of-thumb" which specify a set of actions to be performed for a given situation. Object-oriented programming allows complex systems to be modeled as modular components (which can be easily reused to model other systems or create new components). The procedural programming capabilities provided by CLIPS 6.0 allow CLIPS to represent knowledge in ways similar to those allowed in languages such as C, Pascal, Ada, and LISP. Using CLIPS 6.0, one can develop expert system software using only rule-based programming, only object-oriented programming, only procedural programming, or combinations of the three. CLIPS provides extensive features to support the rule-based programming paradigm including seven conflict resolution strategies, dynamic rule priorities, and truth maintenance. CLIPS 6.0 supports more complex nesting of conditional elements in the if portion of a rule ("and", "or", and "not" conditional elements can be placed within a "not" conditional element). In addition, there is no longer a limitation on the number of multifield slots that a deftemplate can contain. The CLIPS Object-Oriented Language (COOL) provides object-oriented programming capabilities. Features supported by COOL include classes with multiple inheritance, abstraction, encapsulation, polymorphism, dynamic binding, and message passing with message-handlers. CLIPS 6.0 supports tight integration of the rule-based programming features of CLIPS with COOL (that is, a rule can pattern match on objects created using COOL). CLIPS 6.0 provides the capability to define functions, overloaded functions, and global variables interactively. In addition, CLIPS can be embedded within procedural code, called as a subroutine, and integrated with languages such as C, FORTRAN and Ada. CLIPS can be easily extended by a user through the use of several well-defined protocols. CLIPS provides several delivery options for programs including the ability to generate stand alone executables or to load programs from text or binary files. CLIPS 6.0 provides support for the modular development and execution of knowledge bases with the defmodule construct. CLIPS modules allow a set of constructs to be grouped together such that explicit control can be maintained over restricting the access of the constructs by other modules. This type of control is similar to global and local scoping used in languages such as C or Ada. By restricting access to deftemplate and defclass constructs, modules can function as blackboards, permitting only certain facts and instances to be seen by other modules. Modules are also used by rules to provide execution control. The CRSV (Cross-Reference, Style, and Verification) utility included with previous version of CLIPS is no longer supported. The capabilities provided by this tool are now available directly within CLIPS 6.0 to aid in the development, debugging, and verification of large rule bases. COSMIC offers four distribution versions of CLIPS 6.0: UNIX (MSC-22433), VMS (MSC-22434), MACINTOSH (MSC-22429), and IBM PC (MSC-22430). Executable files, source code, utilities, documentation, and examples are included on the program media. All distribution versions include identical source code for the command line version of CLIPS 6.0. This source code should compile on any platform with an ANSI C compiler. Each distribution version of CLIPS 6.0, except that for the Macintosh platform, includes an executable for the command line version. For the UNIX version of CLIPS 6.0, the command line interface has been successfully implemented on a Sun4 running SunOS, a DECstation running DEC RISC ULTRIX, an SGI Indigo Elan running IRIX, a DEC Alpha AXP running OSF/1, and an IBM RS/6000 running AIX. Command line interface executables are included for Sun4 computers running SunOS 4.1.1 or later and for the DEC RISC ULTRIX platform. The makefiles may have to be modified slightly to be used on other UNIX platforms. The UNIX, Macintosh, and IBM PC versions of CLIPS 6.0 each have a platform specific interface. Source code, a makefile, and an executable for the Windows 3.1 interface version of CLIPS 6.0 are provided only on the IBM PC distribution diskettes. Source code, a makefile, and an executable for the Macintosh interface version of CLIPS 6.0 are provided only on the Macintosh distribution diskettes. Likewise, for the UNIX version of CLIPS 6.0, only source code and a makefile for an X-Windows interface are provided. The X-Windows interface requires MIT's X Window System, Version 11, Release 4 (X11R4), the Athena Widget Set, and the Xmu library. The source code for the Athena Widget Set is provided on the distribution medium. The X-Windows interface has been successfully implemented on a Sun4 running SunOS 4.1.2 with the MIT distribution of X11R4 (not OpenWindows), an SGI Indigo Elan running IRIX 4.0.5, and a DEC Alpha AXP running OSF/1 1.2. The VAX version of CLIPS 6.0 comes only with the generic command line interface. ASCII makefiles for the command line version of CLIPS are provided on all the distribution media for UNIX, VMS, and DOS. Four executables are provided with the IBM PC version: a windowed interface executable for Windows 3.1 built using Borland C++ v3.1, an editor for use with the windowed interface, a command line version of CLIPS for Windows 3.1, and a 386 command line executable for DOS built using Zortech C++ v3.1. All four executables are capable of utilizing extended memory and require an 80386 CPU or better. Users needing an 8086/8088 or 80286 executable must recompile the CLIPS source code themselves. Users who wish to recompile the DOS executable using Borland C++ or MicroSoft C must use a DOS extender program to produce an executable capable of using extended memory. The version of CLIPS 6.0 for IBM PC compatibles requires DOS v3.3 or later and/or Windows 3.1 or later. It is distributed on a set of three 1.4Mb 3.5 inch diskettes. A hard disk is required. The Macintosh version is distributed in compressed form on two 3.5 inch 1.4Mb Macintosh format diskettes, and requires System 6.0.5, or higher, and 1Mb RAM. The version for DEC VAX/VMS is available in VAX BACKUP format on a 1600 BPI 9-track magnetic tape (standard distribution medium) or a TK50 tape cartridge. The UNIX version is distributed in UNIX tar format on a .25 inch streaming magnetic tape cartridge (Sun QIC-24). For the UNIX version, alternate distribution media and formats are available upon request. The CLIPS 6.0 documentation includes a User's Guide and a three volume Reference Manual consisting of Basic and Advanced Programming Guides and an Interfaces Guide. An electronic version of the documentation is provided on the distribution medium for each version: in MicroSoft Word format for the Macintosh and PC versions of CLIPS, and in both PostScript format and MicroSoft Word for Macintosh format for the UNIX and DEC VAX versions of CLIPS. CLIPS was developed in 1986 and Version 6.0 was released in 1993.

CLIPS 6.0 - C LANGUAGE INTEGRATED PRODUCTION SYSTEM, VERSION 6.0 (MACINTOSH VERSION)

NASA Technical Reports Server (NTRS)

Riley, G.

1994-01-01

CLIPS, the C Language Integrated Production System, is a complete environment for developing expert systems -- programs which are specifically intended to model human expertise or knowledge. It is designed to allow artificial intelligence research, development, and delivery on conventional computers. CLIPS 6.0 provides a cohesive tool for handling a wide variety of knowledge with support for three different programming paradigms: rule-based, object-oriented, and procedural. Rule-based programming allows knowledge to be represented as heuristics, or "rules-of-thumb" which specify a set of actions to be performed for a given situation. Object-oriented programming allows complex systems to be modeled as modular components (which can be easily reused to model other systems or create new components). The procedural programming capabilities provided by CLIPS 6.0 allow CLIPS to represent knowledge in ways similar to those allowed in languages such as C, Pascal, Ada, and LISP. Using CLIPS 6.0, one can develop expert system software using only rule-based programming, only object-oriented programming, only procedural programming, or combinations of the three. CLIPS provides extensive features to support the rule-based programming paradigm including seven conflict resolution strategies, dynamic rule priorities, and truth maintenance. CLIPS 6.0 supports more complex nesting of conditional elements in the if portion of a rule ("and", "or", and "not" conditional elements can be placed within a "not" conditional element). In addition, there is no longer a limitation on the number of multifield slots that a deftemplate can contain. The CLIPS Object-Oriented Language (COOL) provides object-oriented programming capabilities. Features supported by COOL include classes with multiple inheritance, abstraction, encapsulation, polymorphism, dynamic binding, and message passing with message-handlers. CLIPS 6.0 supports tight integration of the rule-based programming features of CLIPS with COOL (that is, a rule can pattern match on objects created using COOL). CLIPS 6.0 provides the capability to define functions, overloaded functions, and global variables interactively. In addition, CLIPS can be embedded within procedural code, called as a subroutine, and integrated with languages such as C, FORTRAN and Ada. CLIPS can be easily extended by a user through the use of several well-defined protocols. CLIPS provides several delivery options for programs including the ability to generate stand alone executables or to load programs from text or binary files. CLIPS 6.0 provides support for the modular development and execution of knowledge bases with the defmodule construct. CLIPS modules allow a set of constructs to be grouped together such that explicit control can be maintained over restricting the access of the constructs by other modules. This type of control is similar to global and local scoping used in languages such as C or Ada. By restricting access to deftemplate and defclass constructs, modules can function as blackboards, permitting only certain facts and instances to be seen by other modules. Modules are also used by rules to provide execution control. The CRSV (Cross-Reference, Style, and Verification) utility included with previous version of CLIPS is no longer supported. The capabilities provided by this tool are now available directly within CLIPS 6.0 to aid in the development, debugging, and verification of large rule bases. COSMIC offers four distribution versions of CLIPS 6.0: UNIX (MSC-22433), VMS (MSC-22434), MACINTOSH (MSC-22429), and IBM PC (MSC-22430). Executable files, source code, utilities, documentation, and examples are included on the program media. All distribution versions include identical source code for the command line version of CLIPS 6.0. This source code should compile on any platform with an ANSI C compiler. Each distribution version of CLIPS 6.0, except that for the Macintosh platform, includes an executable for the command line version. For the UNIX version of CLIPS 6.0, the command line interface has been successfully implemented on a Sun4 running SunOS, a DECstation running DEC RISC ULTRIX, an SGI Indigo Elan running IRIX, a DEC Alpha AXP running OSF/1, and an IBM RS/6000 running AIX. Command line interface executables are included for Sun4 computers running SunOS 4.1.1 or later and for the DEC RISC ULTRIX platform. The makefiles may have to be modified slightly to be used on other UNIX platforms. The UNIX, Macintosh, and IBM PC versions of CLIPS 6.0 each have a platform specific interface. Source code, a makefile, and an executable for the Windows 3.1 interface version of CLIPS 6.0 are provided only on the IBM PC distribution diskettes. Source code, a makefile, and an executable for the Macintosh interface version of CLIPS 6.0 are provided only on the Macintosh distribution diskettes. Likewise, for the UNIX version of CLIPS 6.0, only source code and a makefile for an X-Windows interface are provided. The X-Windows interface requires MIT's X Window System, Version 11, Release 4 (X11R4), the Athena Widget Set, and the Xmu library. The source code for the Athena Widget Set is provided on the distribution medium. The X-Windows interface has been successfully implemented on a Sun4 running SunOS 4.1.2 with the MIT distribution of X11R4 (not OpenWindows), an SGI Indigo Elan running IRIX 4.0.5, and a DEC Alpha AXP running OSF/1 1.2. The VAX version of CLIPS 6.0 comes only with the generic command line interface. ASCII makefiles for the command line version of CLIPS are provided on all the distribution media for UNIX, VMS, and DOS. Four executables are provided with the IBM PC version: a windowed interface executable for Windows 3.1 built using Borland C++ v3.1, an editor for use with the windowed interface, a command line version of CLIPS for Windows 3.1, and a 386 command line executable for DOS built using Zortech C++ v3.1. All four executables are capable of utilizing extended memory and require an 80386 CPU or better. Users needing an 8086/8088 or 80286 executable must recompile the CLIPS source code themselves. Users who wish to recompile the DOS executable using Borland C++ or MicroSoft C must use a DOS extender program to produce an executable capable of using extended memory. The version of CLIPS 6.0 for IBM PC compatibles requires DOS v3.3 or later and/or Windows 3.1 or later. It is distributed on a set of three 1.4Mb 3.5 inch diskettes. A hard disk is required. The Macintosh version is distributed in compressed form on two 3.5 inch 1.4Mb Macintosh format diskettes, and requires System 6.0.5, or higher, and 1Mb RAM. The version for DEC VAX/VMS is available in VAX BACKUP format on a 1600 BPI 9-track magnetic tape (standard distribution medium) or a TK50 tape cartridge. The UNIX version is distributed in UNIX tar format on a .25 inch streaming magnetic tape cartridge (Sun QIC-24). For the UNIX version, alternate distribution media and formats are available upon request. The CLIPS 6.0 documentation includes a User's Guide and a three volume Reference Manual consisting of Basic and Advanced Programming Guides and an Interfaces Guide. An electronic version of the documentation is provided on the distribution medium for each version: in MicroSoft Word format for the Macintosh and PC versions of CLIPS, and in both PostScript format and MicroSoft Word for Macintosh format for the UNIX and DEC VAX versions of CLIPS. CLIPS was developed in 1986 and Version 6.0 was released in 1993.

Quasi Path Restoration: A post-failure recovery scheme over pre-allocated backup resource for elastic optical networks

NASA Astrophysics Data System (ADS)

Yadav, Dharmendra Singh; Babu, Sarath; Manoj, B. S.

2018-03-01

Spectrum conflict during primary and backup routes assignment in elastic optical networks results in increased resource consumption as well as high Bandwidth Blocking Probability. In order to avoid such conflicts, we propose a new scheme, Quasi Path Restoration (QPR), where we divide the available spectrum into two: (1) primary spectrum (for primary routes allocation) and (2) backup spectrum (for rerouting the data on link failures). QPR exhibits three advantages over existing survivable strategies such as Shared Path Protection (SPP), Primary First Fit Backup Last Fit (PFFBLF), Jointly Releasing and re-establishment Defragmentation SPP (JRDSSPP), and Path Restoration (PR): (1) the conflict between primary and backup spectrum during route assignment is completely eliminated, (2) upon a link failure, connection recovery requires less backup resources compared to SPP, PFFBLF, and PR, and (3) availability of the same backup spectrum on each link improves the recovery guarantee. The performance of our scheme is analyzed with different primary backup spectrum partitions on varying connection-request demands and number of frequency slots. Our results show that QPR provides better connection recovery guarantee and Backup Resources Utilization (BRU) compared to bandwidth recovery of PR strategy. In addition, we compare QPR with Shared Path Protection and Primary First-Fit Backup Last Fit strategies in terms of Bandwidth Blocking Probability (BBP) and average frequency slots per connection request. Simulation results show that BBP of SPP, PFFBLF, and JRDSPP varies between 18.59% and 14.42%, while in QPR, BBP ranges from 2.55% to 17.76% for Cost239, NSFNET, and ARPANET topologies. Also, QPR provides bandwidth recovery between 93.61% and 100%, while in PR, the recovery ranges from 86.81% to 98.99%. It is evident from our analysis that QPR provides a reasonable trade-off between bandwidth blocking probability and connection recoverability.

Geotechnical Feasibility Analysis of Compressed Air Energy Storage (CAES) in Bedded Salt Formations: a Case Study in Huai'an City, China

NASA Astrophysics Data System (ADS)

Zhang, Guimin; Li, Yinping; Daemen, Jaak J. K.; Yang, Chunhe; Wu, Yu; Zhang, Kai; Chen, Yanlong

2015-09-01

The lower reaches of the Yangtze River is one of the most developed regions in China. It is desirable to build compressed air energy storage (CAES) power plants in this area to ensure the safety, stability, and economic operation of the power network. Geotechnical feasibility analysis was carried out for CAES in impure bedded salt formations in Huai'an City, China, located in this region. First, geological investigation revealed that the salt groups in the Zhangxing Block meet the basic geological conditions for CAES storage, even though the possible unfavorable characteristics of the salt formations include bedding and different percentages of impurities. Second, mechanical tests were carried out to determine the mechanical characteristics of the bedded salt formations. It is encouraging that the samples did not fail even when they had undergone large creep deformation. Finally, numerical simulation was performed to evaluate the stability and volume shrinkage of the CAES under the following conditions: the shape of a single cavern is that of a pear; the width of the pillar is adopted as two times the largest diameter; three regular operating patterns were adopted for two operating caverns (internal pressure 9-10.5 MPa, 10-11.5 MPa, and 11-12.5 MPa), while the other two were kept at high pressure (internal pressure 10.5, 11.5, and 12.5 MPa) as backups; an emergency operating pattern in which two operating caverns were kept at atmospheric pressure (0.1 MPa) for emergency while the backups were under operation (9-10.5 MPa), simulated for 12 months at the beginning of the 5th year. The results of the analysis for the plastic zone, displacement, and volume shrinkage support the feasibility of the construction of an underground CAES power station.

Fuel Cells for Backup Power in Telecommunications Facilities (Fact Sheet)

DOE Office of Scientific and Technical Information (OSTI.GOV)

Not Available

2009-04-01

Telecommunications providers rely on backup power to maintain a constant power supply, to prevent power outages, and to ensure the operability of cell towers, equipment, and networks. The backup power supply that best meets these objectives is fuel cell technology.

Highly efficient expression of interleukin-2 under the control of rabbit β-globin intron II gene enhances protective immune responses of porcine reproductive and respiratory syndrome (PRRS) DNA vaccine in pigs.

PubMed

Du, Yijun; Lu, Yu; Wang, Xinglong; Qi, Jing; Liu, Jiyu; Hu, Yue; Li, Feng; Wu, Jiaqiang; Guo, Lihui; Liu, Junzhen; Tao, Haiying; Sun, Wenbo; Chen, Lei; Cong, Xiaoyan; Ren, Sufang; Shi, Jianli; Li, Jun; Wang, Jinbao; Huang, Baohua; Wan, Renzhong

2014-01-01

Highly pathogenic porcine reproductive and respiratory syndrome virus (HP-PRRSV) had caused catastrophic losses in swine industry in China. The current inactivated vaccine provided only limited protection, and the attenuated live vaccine could protect piglets against the HP-PRRSV but there was a possibility that the attenuated virus returned to high virulence. In this study, the eukaryotic expression vector pVAX1© was modified under the control of rabbit β-globin intron II gene and the modified vector pMVAX1© was constructed. Porcine interleukin-2 (IL-2) and GP3-GP5 fusion protein of HP-PRRSV strain SD-JN were highly expressed by pMVAX1©. Mice inoculated with pMVAX1©-GP35 developed significantly higher PRRSV-specific antibody responses and T cell proliferation than those vaccinated with pVAX1©-GP35. pMVAX1©-GP35 was selected as PRRS DNA vaccine candidate and co-administrated with pVAX1©-IL-2 or pMVAX1©-IL-2 in pigs. pMVAX1©-IL-2+pMVAX1©-GP35 could provide enhanced PRRSV-specific antibody responses, T cell proliferation, Th1-type and Th2-type cytokine responses and CTL responses than pMVAX1©-GP35 and pVAX1©-IL-2+pMVAX1©-GP35. Following homologous challenge with HP-PRRSV strain SD-JN, similar with attenuated PRRS vaccine group, pigs inoculated with pMVAX1©-IL-2+pMVAX1©-GP35 showed no clinical signs, almost no lung lesions and no viremia, as compared to those in pMVAX1©-GP35 and pVAX1©-IL-2+pMVAX1©-GP35 groups. It indicated that pMVAX1©-IL-2 effectively increases humoral and cell mediated immune responses of pMVAX1©-GP35. Co-administration of pMVAX1©-IL-2 and pMVAX1©-GP35 might be attractive candidate vaccines for preventing HP-PRRSV infections.

[Antitumor effects of matrix protein of vesicular stomatic virus on EL4 lymphoma mice].

PubMed

Lin, Shi-jia; Yu, Qin-mei; Meng, Wen-tong; Wen, Yan-jun; Chen, Li-juan; Niu, Ting

2011-03-01

To explore antitumor effects of plasmid pcDNA3. 1-MP encoding matrix protein of vesicular stomatitis virus (VSV) complexed with cationic liposome (DOTAP:CHOL) in mice with EL4 lymphoma. C57BL/6 mouse model with EL4 lymphoma was established. Sixty mice bearing EL4 lymphoma were divided randomly into five groups including Lip-MP, Lip-pVAX, Lip, ADM and NS groups, which were intravenously injected with liposome-pcDNA 3. 1-MP complex, liposome-pVAX complex, empty liposome, Adriamycin and normal saline respectively every three days. Tumor volumes and survival time were monitored. Microvessel density and tumor proliferative index in tumor tissues were determined by CD31, Ki-67 immunohistochemistry staining, meanwhile the tumor apoptosis index was measured by TUNEL method. From 6 days after treatments on, the tumor volume in Lip-MP group was much smaller than that in Lip-pVAX, Lip and NS group (P < 0.05). The median survival time of mice in Lip-MP group, 44 days after inoculation of tumor cells, was significantly higher than that in other groups (P < 0.05), which was 39 days, 38.5 days and 34 days in Lip-pVAX, Lip and NS groups respectively. The MVD value in tumor tissues in Lip-MP group was less than that in Lip-pVAX, Lip and NS groups (P < 0.05). Ki67 staining revealed that Lip-MP complex apparently suppressed the proliferation of EL4 tumor cells in vivo (P < 0.05). TUNEL assays showed that apoptosis index of tumor cells in Lip-MP group, 10.60 +/- 1.71, was much higher than that in other three groups (P < 0.05). Lip-MP complex, the plasmid encoding matrix protein of VSV (VSV-MP) encapsulated in cationic liposome, significantly inhibited the growth of tumor and prolonged the survival of mice bearing EL4 lymphoma, which may be related to the induction of tumor cell apoptosis, inhibition of tumor angiogenesis, and suppression of tumor cell proliferation.

Impact of vaccination on infection with Vietnam H5N1 high pathogenicity avian influenza virus in hens and the eggs they lay.

PubMed

Bertran, Kateri; Moresco, Kira; Swayne, David E

2015-03-10

High pathogenicity avian influenza virus (HPAIV) infections in chickens negatively impact egg production and cause egg contamination. Previously, vaccination maintained egg production and reduced egg contamination when challenged with a North American H5N2 HPAIV. However, Asian H5N1 HPAIV infection has some characteristics of increased pathogenicity compared to other H5 HPAIV such as more rapid drop and complete cessation in egg production. Sham (vaccinated at 25 and 28 weeks of age), inactivated H5N1 Once (1X-H5-Vax; vaccinated at 28 weeks of age only) and inactivated H5N1 Twice (2X-H5-Vax; vaccinated at 25 and 28 weeks of age) vaccinated adult White Leghorn hens were challenged intranasally at 31 weeks of age with 6.1 log10 mean embryo infectious doses (EID50) of clade 2.3.2.1a H5N1 HPAIV (A/chicken/Vietnam/NCVD-675/2011) which was homologous to the inactivated vaccine. Sham-vaccinated layers experienced 100% mortality within 3 days post-challenge; laid soft and thin-shelled eggs; had recovery of virus from oral swabs and in 53% of the eggs from eggshell surface (35%), yolk (24%), and albumin (41%); and had very high titers of virus (average 7.91 log10 EID50/g) in all segments of the oviduct and ovary. By comparison, 1X- and 2X-H5-Vax challenged hens survived infection, laid similar number of eggs pre- and post-challenge, all eggs had normal egg shell quality, and had significantly fewer contaminated eggs with reduced virus quantity. The 2X-H5-Vax hens had significantly higher HI titers by the day of challenge (304 GMT) and at termination (512 GMT) than 1X-H5-Vax hens (45 GMT and 128 GMT). The current study demonstrated that AIV infections caused by clade 2.3.2.1a H5N1 variants can be effectively controlled by either double or single homologous vaccination. Published by Elsevier Ltd.

Vcsa1 Acts as a Marker of Erectile Function Recovery After Gene Therapeutic and Pharmacological Interventions

PubMed Central

Calenda, Giulia; Tong, Yuehong; Tar, Moses; Lowe, Daniel; Siragusa, Joseph; Melman, Arnold; Davies, Kelvin P.

2010-01-01

Purpose We identified molecular markers of erectile function, particularly those responding to erectile dysfunction treatment. Materials and Methods Sprague-Dawley retired breeder rats were intracorporeally injected with pVAX-hSlo, pSMAA-hSlo or the control plasmid pVAX. One week later the intracorporeal pressure-to-blood pressure ratio and gene expression were determined by microarray analysis and quantitative reverse transcriptase-polymerase chain reaction. Rat corporeal cells were transfected in vitro with pVAX-hSlo, pSMAA-hSlo or pVAX and the change in gene expression was determined. We also determined whether Vcsa1 expression was changed after pharmacotherapy using tadalafil. Results Animals treated with vectors expressing hSlo had significantly improved erectile function compared to that in controls, accompanied by changed expression of a subset of genes. Vcsa1 was one of the genes that was most changed in expression (the third of approximately 31,000 with greater than 10-fold up-regulation). Changes in gene expression were different than those observed in corporeal cells transfected in vitro, distinguishing gene expression changes that were a direct effect of hSlo over expression. When tadalafil was administered in retired breeder rats, the Vcsa1 transcript increased 4-fold in corporeal tissue compared to that in untreated controls. Conclusions Our study identifies a set of genes that are changed in response to improved erectile function, rather than as a direct effect of treatment. We noted Vcsa1 may act as marker of the restoration of erectile function after gene transfer and pharmacotherapy. PMID:19375734

Vcsa1 acts as a marker of erectile function recovery after gene therapeutic and pharmacological interventions.

PubMed

Calenda, Giulia; Tong, Yuehong; Tar, Moses; Lowe, Daniel; Siragusa, Joseph; Melman, Arnold; Davies, Kelvin P

2009-06-01

We identified molecular markers of erectile function, particularly those responding to erectile dysfunction treatment. Sprague-Dawley retired breeder rats were intracorporeally injected with pVAX-hSlo, pSMAA-hSlo or the control plasmid pVAX. One week later the intracorporeal pressure-to-blood pressure ratio and gene expression were determined by microarray analysis and quantitative reverse transcriptase-polymerase chain reaction. Rat corporeal cells were transfected in vitro with pVAX-hSlo, pSMAA-hSlo or pVAX and the change in gene expression was determined. We also determined whether Vcsa1 expression was changed after pharmacotherapy using tadalafil. Animals treated with vectors expressing hSlo had significantly improved erectile function compared to that in controls, accompanied by changed expression of a subset of genes. Vcsa1 was one of the genes that was most changed in expression (the third of approximately 31,000 with greater than 10-fold up-regulation). Changes in gene expression were different than those observed in corporeal cells transfected in vitro, distinguishing gene expression changes that were a direct effect of hSlo over expression. When tadalafil was administered in retired breeder rats, the Vcsa1 transcript increased 4-fold in corporeal tissue compared to that in untreated controls. Our study identifies a set of genes that are changed in response to improved erectile function, rather than as a direct effect of treatment. We noted Vcsa1 may act as marker of the restoration of erectile function after gene transfer and pharmacotherapy.

Immune responses and protection after DNA vaccination against Toxoplasma gondii calcium-dependent protein kinase 2 (TgCDPK2)

PubMed Central

Chen, Kai; Wang, Jin-Lei; Huang, Si-Yang; Yang, Wen-Bin; Zhu, Wei-Ning; Zhu, Xing-Quan

2017-01-01

Toxoplasma gondii, an intracellular zoonotic protozoan parasite, is possibly the most widespread parasite of warm-blooded animals and can cause serious public health problems and economic losses worldwide. TgCDPK2, a member of the T. gondii calcium-dependent protein kinase family, was recently identified as an essential regulator for viable cyst development in T. gondii. In the present study, we evaluated the protective immunity induced by DNA vaccination based on a recombinant eukaryotic plasmid, pVAX-TgCDPK2, against acute toxoplasmosis in mice. BALB/c mice were intramuscularly immunized with pVAX-TgCDPK2 plasmid and then challenged by infection with the highly virulent RH strain of T. gondii. The specific immune responses and protective efficacy against T. gondii were analyzed by cytokine and serum antibody measurements, lymphocyte proliferation assays, flow cytometric on lymphocytes and the survival time of mice after challenge. Our results showed that mice immunized with pVAX-TgCDPK2 could elicit special humoral and cellular responses, with higher levels of IgG antibody, and increased levels of Th1-type cytokines IFN-γ, IL-12(p70), and CD3 + CD4 + CD8 − and CD3 + CD8 + CD4 − T cells, and had a prolonged survival time (14.0 ± 2.32 days) compared to control mice. These results demonstrate that pVAX-TgCDPK2 is a potential vaccine candidate against acute toxoplasmosis. PMID:29119944

Disaster recovery plan for HANDI 2000 business management system

DOE Office of Scientific and Technical Information (OSTI.GOV)

Adams, D.E.

The BMS production implementation will be complete by October 1, 1998 and the server environment will be comprised of two types of platforms. The PassPort Supply and the PeopleSoft Financials will reside on LNIX servers and the PeopleSoft Human Resources and Payroll will reside on Microsoft NT servers. Because of the wide scope and the requirements of the COTS products to run in various environments backup and recovery responsibilities are divided between two groups in Technical Operations. The Central Computer Systems Management group provides support for the LTNIX/NT Backup Data Center, and the Network Infrastructure Systems group provides support formore » the NT Application Server Backup outside the Data Center. The disaster recovery process is dependent on a good backup and recovery process. Information and integrated system data for determining the disaster recovery process is identified from the Fluor Daniel Hanford (FDH) Risk Assessment Plan, Contingency Plan, and Backup and Recovery Plan, and Backup Form for HANDI 2000 BMS.« less

Fuel Cell Backup Power System for Grid Service and Micro-Grid in Telecommunication Applications: Preprint

DOE Office of Scientific and Technical Information (OSTI.GOV)

Ma, Zhiwen; Eichman, Joshua D; Kurtz, Jennifer M

This paper presents the feasibility and economics of using fuel cell backup power systems in telecommunication cell towers to provide grid services (e.g., ancillary services, demand response). The fuel cells are able to provide power for the cell tower during emergency conditions. This study evaluates the strategic integration of clean, efficient, and reliable fuel cell systems with the grid for improved economic benefits. The backup systems have potential as enhanced capability through information exchanges with the power grid to add value as grid services that depend on location and time. The economic analysis has been focused on the potential revenuemore » for distributed telecommunications fuel cell backup units to provide value-added power supply. This paper shows case studies on current fuel cell backup power locations and regional grid service programs. The grid service benefits and system configurations for different operation modes provide opportunities for expanding backup fuel cell applications responsive to grid needs.« less

Integration Of An MR Image Network Into A Clinical PACS

NASA Astrophysics Data System (ADS)

Ratib, Osman M.; Mankovich, Nicholas J.; Taira, Ricky K.; Cho, Paul S.; Huang, H. K.

1988-06-01

A direct link between a clinical pediatric PACS module and a FONAR MRI image network was implemented. The original MR network combines together the MR scanner, a remote viewing station and a central archiving station. The pediatric PACS directly connects to the archiving unit through an Ethernet TCP-IP network adhering to FONAR's protocol. The PACS communication software developed supports the transfer of patient studies and the patient information directly from the MR archive database to the pediatric PACS. In the first phase of our project we developed a package to transfer data between a VAX-111750 and the IBM PC I AT-based MR archive database through the Ethernet network. This system served as a model for PACS-to-modality network communication. Once testing was complete on this research network, the software and network hardware was moved to the clinical pediatric VAX for full PACS integration. In parallel to the direct transmission of digital images to the Pediatric PACS, a broadband communication system in video format was developed for real-time broadcasting of images originating from the MR console to 8 remote viewing stations distributed in the radiology department. These analog viewing stations allow the radiologists to directly monitor patient positioning and to select the scan levels during a patient examination from remote locations in the radiology department. This paper reports (1) the technical details of this implementation, (2) the merits of this network development scheme, and (3) the performance statistics of the network-to-PACS interface.

CFORM- LINEAR CONTROL SYSTEM DESIGN AND ANALYSIS: CLOSED FORM SOLUTION AND TRANSIENT RESPONSE OF THE LINEAR DIFFERENTIAL EQUATION

NASA Technical Reports Server (NTRS)

Jamison, J. W.

1994-01-01

CFORM was developed by the Kennedy Space Center Robotics Lab to assist in linear control system design and analysis using closed form and transient response mechanisms. The program computes the closed form solution and transient response of a linear (constant coefficient) differential equation. CFORM allows a choice of three input functions: the Unit Step (a unit change in displacement); the Ramp function (step velocity); and the Parabolic function (step acceleration). It is only accurate in cases where the differential equation has distinct roots, and does not handle the case for roots at the origin (s=0). Initial conditions must be zero. Differential equations may be input to CFORM in two forms - polynomial and product of factors. In some linear control analyses, it may be more appropriate to use a related program, Linear Control System Design and Analysis (KSC-11376), which uses root locus and frequency response methods. CFORM was written in VAX FORTRAN for a VAX 11/780 under VAX VMS 4.7. It has a central memory requirement of 30K. CFORM was developed in 1987.

Using backup generators for meeting peak electricity demand: a sensitivity analysis on emission controls, location, and health endpoints.

PubMed

Gilmore, Elisabeth A; Adams, Peter J; Lave, Lester B

2010-05-01

Generators installed for backup power during blackouts could help satisfy peak electricity demand; however, many are diesel generators with nonnegligible air emissions that may damage air quality and human health. The full (private and social) cost of using diesel generators with and without emission control retrofits for fine particulate matter (PM2.5) and nitrogen oxides (NOx) were compared with a new natural gas turbine peaking plant. Lower private costs were found for the backup generators because the capital costs are mostly ascribed to reliability. To estimate the social costs from air quality, the changes in ambient concentrations of ozone (O3) and PM2.5 were modeled using the Particulate Matter Comprehensive Air Quality Model with extensions (PMCAMx) chemical transport model. These air quality changes were translated to their equivalent human health effects using concentration-response functions and then into dollars using estimates of "willingness-to-pay" to avoid ill health. As a case study, 1000 MW of backup generation operating for 12 hr/day for 6 days in each of four eastern U.S. cities (Atlanta, Chicago, Dallas, and New York) was modeled. In all cities, modeled PM2.5 concentrations increased (up to 5 microg/m3) due mainly to primary emissions. Smaller increases and decreases were observed for secondary PM2.5 with more variation between cities. Increases in NOx, emissions resulted in significant nitrate formation (up to 1 microg/m3) in Atlanta and Chicago. The NOx emissions also caused O3 decreases in the urban centers and increases in the surrounding areas. For PM2.5, a social cost of approximately $2/kWh was calculated for uncontrolled diesel generators in highly populated cities but was under 10 cent/kWh with PM2.5 and NOx controls. On a full cost basis, it was found that properly controlled diesel generators are cost-effective for meeting peak electricity demand. The authors recommend NOx and PM2.5 controls.

75 FR 81417 - Airworthiness Directives; Piper Aircraft, Inc. Model PA-28-161 Airplanes

Federal Register 2010, 2011, 2012, 2013, 2014

2010-12-28

... authority digital engine control (FADEC) backup battery, replacing the supplement pilot's operating handbook... installation of a FADEC backup battery, replacement of the supplement pilot's operating handbook and FAA... backup battery 7 work-hours x $85 per $780 $1,375 Not hour = $595. applicable. Authority for This...

Multi-criteria decision analysis of concentrated solar power with thermal energy storage and dry cooling.

PubMed

Klein, Sharon J W

2013-12-17

Decisions about energy backup and cooling options for parabolic trough (PT) concentrated solar power have technical, economic, and environmental implications. Although PT development has increased rapidly in recent years, energy policies do not address backup or cooling option requirements, and very few studies directly compare the diverse implications of these options. This is the first study to compare the annual capacity factor, levelized cost of energy (LCOE), water consumption, land use, and life cycle greenhouse gas (GHG) emissions of PT with different backup options (minimal backup (MB), thermal energy storage (TES), and fossil fuel backup (FF)) and different cooling options (wet (WC) and dry (DC). Multicriteria decision analysis was used with five preference scenarios to identify the highest-scoring energy backup-cooling combination for each preference scenario. MB-WC had the highest score in the Economic and Climate Change-Economy scenarios, while FF-DC and FF-WC had the highest scores in the Equal and Availability scenarios, respectively. TES-DC had the highest score for the Environmental scenario. DC was ranked 1-3 in all preference scenarios. Direct comparisons between GHG emissions and LCOE and between GHG emissions and land use suggest a preference for TES if backup is require for PT plants to compete with baseload generators.

An Image Archive With The ACR/NEMA Message Formats

NASA Astrophysics Data System (ADS)

Seshadri, Sridhar B.; Khalsa, Satjeet; Arenson, Ronald L.; Brikman, Inna; Davey, Michael J.

1988-06-01

An image archive has been designed to manage and store radiologic images received from within the main Hospital and a from a suburban orthopedic clinic. Images are stored on both magnetic as well as optical media. Prior comparison examinations are combined with the current examination to generate a 'viewing folder' that is sent to the display station for primary diagnosis. An 'archive-manager' controls the database managment, periodic optical disk backup and 'viewing-folder' generation. Images are converted into the ACR/NEMA message format before being written to the optical disk. The software design of the 'archive-manager' and its associated modules is presented. Enhancements to the system are discussed.

Program Models A Laser Beam Focused In An Aerosol Spray

NASA Technical Reports Server (NTRS)

Barton, J. P.

1996-01-01

Monte Carlo analysis performed on packets of light. Program for Analysis of Laser Beam Focused Within Aerosol Spray (FLSPRY) developed for theoretical analysis of propagation of laser pulse optically focused within aerosol spray. Applied for example, to analyze laser ignition arrangement in which focused laser pulse used to ignite liquid aerosol fuel spray. Scattering and absorption of laser light by individual aerosol droplets evaluated by use of electromagnetic Lorenz-Mie theory. Written in FORTRAN 77 for both UNIX-based computers and DEC VAX-series computers. VAX version of program (LEW-16051). UNIX version (LEW-16065).

Fault-tolerant back-up archive using an ASP model for disaster recovery

NASA Astrophysics Data System (ADS)

Liu, Brent J.; Huang, H. K.; Cao, Fei; Documet, Luis; Sarti, Dennis A.

2002-05-01

A single point of failure in PACS during a disaster scenario is the main archive storage and server. When a major disaster occurs, it is possible to lose an entire hospital's PACS data. Few current PACS archives feature disaster recovery, but the design is limited at best. These drawbacks include the frequency with which the back-up is physically removed to an offsite facility, the operational costs associated to maintain the back-up, the ease-of-use to perform the backup consistently and efficiently, and the ease-of-use to perform the PACS image data recovery. This paper describes a novel approach towards a fault-tolerant solution for disaster recovery of short-term PACS image data using an Application Service Provider model for service. The ASP back-up archive provides instantaneous, automatic backup of acquired PACS image data and instantaneous recovery of stored PACS image data all at a low operational cost. A back-up archive server and RAID storage device is implemented offsite from the main PACS archive location. In the example of this particular hospital, it was determined that at least 2 months worth of PACS image exams were needed for back-up. Clinical data from a hospital PACS is sent to this ASP storage server in parallel to the exams being archived in the main server. A disaster scenario was simulated and the PACS exams were sent from the offsite ASP storage server back to the hospital PACS. Initially, connectivity between the main archive and the ASP storage server is established via a T-1 connection. In the future, other more cost-effective means of connectivity will be researched such as the Internet 2. A disaster scenario was initiated and the disaster recovery process using the ASP back-up archive server was success in repopulating the clinical PACS within a short period of time. The ASP back-up archive was able to recover two months of PACS image data for comparison studies with no complex operational procedures. Furthermore, no image data loss was encountered during the recovery.

78 FR 77171 - Proposed Disposal of George H.W. Bush and Clinton Administration Electronic Backup Tapes

Federal Register 2010, 2011, 2012, 2013, 2014

2013-12-20

... NATIONAL ARCHIVES AND RECORDS ADMINISTRATION [NARA-2014-011] Proposed Disposal of George H.W. Bush... George H.W. Bush and Clinton Administration Disaster Recovery Backup Tapes; final agency action. SUMMARY... collection of disaster recovery backup tapes from the George H.W. Bush and Clinton administrations under the...

30 CFR 75.1101-9 - Back-up water system.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 30 Mineral Resources 1 2010-07-01 2010-07-01 false Back-up water system. 75.1101-9 Section 75.1101-9 Mineral Resources MINE SAFETY AND HEALTH ADMINISTRATION, DEPARTMENT OF LABOR COAL MINE SAFETY AND HEALTH MANDATORY SAFETY STANDARDS-UNDERGROUND COAL MINES Fire Protection § 75.1101-9 Back-up water system...

30 CFR 75.1101-9 - Back-up water system.

Code of Federal Regulations, 2011 CFR

2011-07-01

... 30 Mineral Resources 1 2011-07-01 2011-07-01 false Back-up water system. 75.1101-9 Section 75.1101-9 Mineral Resources MINE SAFETY AND HEALTH ADMINISTRATION, DEPARTMENT OF LABOR COAL MINE SAFETY AND HEALTH MANDATORY SAFETY STANDARDS-UNDERGROUND COAL MINES Fire Protection § 75.1101-9 Back-up water system...

12 CFR 201.4 - Availability and terms of credit.

Code of Federal Regulations, 2014 CFR

2014-01-01

... overnight, as a backup source of funding to a depository institution that is in generally sound financial... to a few weeks as a backup source of funding to a depository institution if, in the judgment of the... very short-term basis, usually overnight, as a backup source of funding to a depository institution...

30 CFR 75.1101-9 - Back-up water system.

Code of Federal Regulations, 2014 CFR

2014-07-01

... 30 Mineral Resources 1 2014-07-01 2014-07-01 false Back-up water system. 75.1101-9 Section 75.1101-9 Mineral Resources MINE SAFETY AND HEALTH ADMINISTRATION, DEPARTMENT OF LABOR COAL MINE SAFETY AND HEALTH MANDATORY SAFETY STANDARDS-UNDERGROUND COAL MINES Fire Protection § 75.1101-9 Back-up water system...

30 CFR 75.1101-9 - Back-up water system.

Code of Federal Regulations, 2012 CFR

2012-07-01

... 30 Mineral Resources 1 2012-07-01 2012-07-01 false Back-up water system. 75.1101-9 Section 75.1101-9 Mineral Resources MINE SAFETY AND HEALTH ADMINISTRATION, DEPARTMENT OF LABOR COAL MINE SAFETY AND HEALTH MANDATORY SAFETY STANDARDS-UNDERGROUND COAL MINES Fire Protection § 75.1101-9 Back-up water system...

30 CFR 75.1101-9 - Back-up water system.

Code of Federal Regulations, 2013 CFR

2013-07-01

... 30 Mineral Resources 1 2013-07-01 2013-07-01 false Back-up water system. 75.1101-9 Section 75.1101-9 Mineral Resources MINE SAFETY AND HEALTH ADMINISTRATION, DEPARTMENT OF LABOR COAL MINE SAFETY AND HEALTH MANDATORY SAFETY STANDARDS-UNDERGROUND COAL MINES Fire Protection § 75.1101-9 Back-up water system...

78 FR 54707 - Self-Regulatory Organizations; The Options Clearing Corporation; Notice of Filing of Proposed...

Federal Register 2010, 2011, 2012, 2013, 2014

2013-09-05

... Statement Adopted Under Rule 205 Entitled ``Back-up Communication Channel to Internet Access'' August 29... ``Back-up Communication Channel to Internet Access'' requiring clearing members that use the Internet as their primary means to access OCC's information and data systems to maintain a secure back-up means of...

Rates for backup service under PURPA when the supplying utility has excess generating capacity

DOE Office of Scientific and Technical Information (OSTI.GOV)

Not Available

Under PURPA, cogenerators are entitled to receive backup service. It is often said that tariffs for backup service should reflect the low probability that an unscheduled outage will occur during system peak. This memorandum concludes that probabilistic analysis of contribution to coincident peak demand is not relevant under PURPA during periods in which a utility system is experiencing generating capacity surpluses, and that in such situations, backup rates should be designed so that should the customer insist on installing a cogeneration system, that the customer's contribution to fixed costs remains constant. The reason for this is to assure that prospectivemore » cogenerators receive appropriate pricing signals in their assessment of proposed cogeneration projects, and should they decide to install cogeneration facilities requiring backup service, to hold the remaining customers on the system harmless.« less

Applying secret sharing for HIS backup exchange.

PubMed

Kuroda, Tomohiro; Kimura, Eizen; Matsumura, Yasushi; Yamashita, Yoshinori; Hiramatsu, Haruhiko; Kume, Naoto; Sato, Atsushi

2013-01-01

To secure business continuity is indispensable for hospitals to fulfill its social responsibility under disasters. Although to back up the data of the hospital information system (HIS) at multiple remote sites is a key strategy of business continuity plan (BCP), the requirements to treat privacy sensitive data jack up the cost for the backup. The secret sharing is a method to split an original secret message up so that each individual piece is meaningless, but putting sufficient number of pieces together to reveal the original message. The secret sharing method eases us to exchange HIS backups between multiple hospitals. This paper evaluated the feasibility of the commercial secret sharing solution for HIS backup through several simulations. The result shows that the commercial solution is feasible to realize reasonable HIS backup exchange platform when template of contract between participating hospitals is ready.

An enhanced anti-tumor effect of apoptin-cecropin B on human hepatoma cells by using bacterial magnetic particle gene delivery system.

PubMed

Wang, Xi; Wang, Ji-Gui; Geng, Yuan-Yuan; Wang, Jiao-Jiao; Zhang, Xiao-Mei; Yang, Shuang-Shuang; Jiang, Wei; Liu, Wei-Quan

2018-02-05

The gene therapy of cancer, due to the limit of its efficiency and safety, has not been widely used in clinical. Recently, bacterial magnetic particles (BMPs), which are membrane-bound nanocrystals found in magnetotactic bacteria, have been exploited as a new gene delivery system. However, its application on gene therapy remains to be explored. In our previous study, we found that a combination of cecropin B (ABPs) and apoptin (VP3) could serve as an effective gene therapeutic agent. Thus, in this study, we used BMPs to deliver the co-expression plasmid of these two gene, namely pVAX1-VA, and evaluated its therapeutic effect on human hepatocellular carcinoma (HepG2). Our results showed that BMPs significantly improved the efficiency of gene transfection (almost 3-fold than Lipofectamine 2000 at 48 h, P < .001), which led to stronger apoptosis (in a peak almost 2-fold than Lipofectamine 2000-pVAX1-VA, P < .01) and growth inhibition of HepG2 cells. More importantly, compared with Lipofectamine 2000-pVAX1-VA group, BMP-pVAX1-VA strikingly inhibited tumor growth (0.60 ± 0.09 g vs. 0.88 ± 0.11 g, P < .05) in nude mouse tumor models and increased the tumor-infiltrating lymphocytes considerably without apparent cytotoxicity. These findings suggest that BMPs could be an attractive gene delivery system for gene therapy and provide a potential available treatment for human hepatocellular carcinoma and maybe some other kinds of tumors. Copyright © 2018 Elsevier Inc. All rights reserved.

Rapid discovery of peptide capture candidates with demonstrated specificity for structurally similar toxins

NASA Astrophysics Data System (ADS)

Sarkes, Deborah A.; Hurley, Margaret M.; Coppock, Matthew B.; Farrell, Mikella E.; Pellegrino, Paul M.; Stratis-Cullum, Dimitra N.

2016-05-01

Peptides have emerged as viable alternatives to antibodies for molecular-based sensing due to their similarity in recognition ability despite their relative structural simplicity. Various methods for peptide capture reagent discovery exist, including phage display, yeast display, and bacterial display. One of the primary advantages of peptide discovery by bacterial display technology is the speed to candidate peptide capture agent, due to both rapid growth of bacteria and direct utilization of the sorted cells displaying each individual peptide for the subsequent round of biopanning. We have previously isolated peptide affinity reagents towards protective antigen of Bacillus anthracis using a commercially available automated magnetic sorting platform with improved enrichment as compared to manual magnetic sorting. In this work, we focus on adapting our automated biopanning method to a more challenging sort, to demonstrate the specificity possible with peptide capture agents. This was achieved using non-toxic, recombinant variants of ricin and abrin, RiVax and abrax, respectively, which are structurally similar Type II ribosomal inactivating proteins with significant sequence homology. After only two rounds of biopanning, enrichment of peptide capture candidates binding abrax but not RiVax was achieved as demonstrated by Fluorescence Activated Cell Sorting (FACS) studies. Further sorting optimization included negative sorting against RiVax, proper selection of autoMACS programs for specific sorting rounds, and using freshly made buffer and freshly thawed protein target for each round of biopanning for continued enrichment over all four rounds. Most of the resulting candidates from biopanning for abrax binding peptides were able to bind abrax but not RiVax, demonstrating that short peptide sequences can be highly specific even at this early discovery stage.

STS-9 payload specialists and backup in training session

NASA Technical Reports Server (NTRS)

1983-01-01

Two Spacelab 1 payload specialists and a backup for that flight prepare for a training session in the JSC mockup and integration laboratory. Fully decked out in the Shuttle constant wear garments (foreground) are Ulf Merbold, left, and Byron K. Licktenberg, prime crewmembers on the STS-9 team. In civilian clothes is payload specialist backup Michael L. Lampton.

Expedition 19 State Commission

NASA Image and Video Library

2009-03-24

Spaceflight Participant Charles Simonyi, left, Expedition 19 Commander Gennady I. Padalka, Flight Engineer Michael R. Barratt, third from left, backup Expedition 19 flight engineer Maxim Suraev, backup commander Jeffrey Williams and backup spaceflight participant Esther Dyson, far right, are seen in quarantine behind glass during the State Commission meeting on Wednesday, March 25, 2009 in Baikonur, Kazakhstan. Photo Credit: (NASA/Bill Ingalls)

Mechanization of and experience with a triplex fly-by-wire backup control system

NASA Technical Reports Server (NTRS)

Lock, W. P.; Petersen, W. R.; Whitman, G. B.

1976-01-01

A redundant three axis analog control system was designed and developed to back up a digital fly by wire control system for an F-8C airplane. The mechanization and operational experience with the backup control system, the problems involved in synchronizing it with the primary system, and the reliability of the system are discussed. The backup control system was dissimilar to the primary system, and it provided satisfactory handling through the flight envelope evaluated. Limited flight tests of a variety of control tasks showed that control was also satisfactory when the backup control system was controlled by a minimum displacement (force) side stick. The operational reliability of the F-8 digital fly by wire control system was satisfactory, with no unintentional downmodes to the backup control system in flight. The ground and flight reliability of the system's components is discussed.

STS-47 crew & backups pose for portrait in SLJ module at KSC during training

NASA Image and Video Library

1992-07-25

S92-44303 --- STS-47 Endeavour, Orbiter Vehicle (OV) 105, crew members and back-up payload specialists, wearing clean suits, pose for a group portrait in the Spacelab Japan (SLJ) module. The team is at the Kennedy Space Center's (KSC's) Orbiter Processing Facility (OPF) to inspect SLJ configuration and OV-105 preparations. Kneeling, from left, are back-up Payload Specialist Chiaki Naito-Mukai; Mission Specialist N. Jan Davis; and backup Payload Specialist Takao Doi. Standing, from the left, are Pilot Curtis L. Brown,Jr; Payload Commander Mark C. Lee; Jerome Apt; Payload Specialist Mamoru Mohri; Commander Robert L. Gibson; Mae C. Jemison; and back-up Payload Specialist Stanely L. Koszelak. Mohri, Mukai, and Doi represent the National Space Development Agency of Japan (NASDA). View provided by KSC with alternate KSC number KSC-92PC-1647. Photo credit: NASA

jsc2017e136055 - On a snowy night at Red Square in Moscow, Expedition 54-55 backup crewmember Jeanette Epps of NASA lays flowers at the Kremlin Wall where Russian space icons are interred in traditional pre-launch ceremonies Nov. 30. Looking on are backup

NASA Image and Video Library

2017-11-30

jsc2017e136055 - On a snowy night at Red Square in Moscow, Expedition 54-55 backup crewmember Jeanette Epps of NASA lays flowers at the Kremlin Wall where Russian space icons are interred in traditional pre-launch ceremonies Nov. 30. Looking on are backup crewmembers Sergey Prokopyev of the Russian Federal Space Agency (Roscosmos, left) and Alexander Gerst of the European Space Agency. They are backups to Anton Shkaplerov of Roscosmos, Scott Tingle of NASA and Norishige Kanai of the Japan Aerospace Exploration Agency (JAXA), who will launch from the Baikonur Cosmodrome in Kazakhstan on the Soyuz MS-07 spacecraft Dec. 17 for a five-month mission on the International Space Station...Andrey Shelepin/Gagarin Cosmonaut Training Center.

Practical, redundant, failure-tolerant, self-reconfiguring embedded system architecture

DOEpatents

Klarer, Paul R.; Hayward, David R.; Amai, Wendy A.

2006-10-03

This invention relates to system architectures, specifically failure-tolerant and self-reconfiguring embedded system architectures. The invention provides both a method and architecture for redundancy. There can be redundancy in both software and hardware for multiple levels of redundancy. The invention provides a self-reconfiguring architecture for activating redundant modules whenever other modules fail. The architecture comprises: a communication backbone connected to two or more processors and software modules running on each of the processors. Each software module runs on one processor and resides on one or more of the other processors to be available as a backup module in the event of failure. Each module and backup module reports its status over the communication backbone. If a primary module does not report, its backup module takes over its function. If the primary module becomes available again, the backup module returns to its backup status.

Eigensystem realization algorithm user's guide forVAX/VMS computers: Version 931216

NASA Technical Reports Server (NTRS)

Pappa, Richard S.

1994-01-01

The eigensystem realization algorithm (ERA) is a multiple-input, multiple-output, time domain technique for structural modal identification and minimum-order system realization. Modal identification is the process of calculating structural eigenvalues and eigenvectors (natural vibration frequencies, damping, mode shapes, and modal masses) from experimental data. System realization is the process of constructing state-space dynamic models for modern control design. This user's guide documents VAX/VMS-based FORTRAN software developed by the author since 1984 in conjunction with many applications. It consists of a main ERA program and 66 pre- and post-processors. The software provides complete modal identification capabilities and most system realization capabilities.

AdA Compiler Validation Summary Report: Certificate Number: 910920W1. 11214 Verdix Corporation, VADS VAX VMS= AMD 29K, VAda-110-03525, Version 6.04, MicroVAX 3600 (Host) to Ironics IV9001 Board (Target). MVME147 (Target)

DTIC Science & Technology

1991-09-20

Agreement Number: 91-07-16- VRX See section 3.1 for any additional information about the testing environment. As a result of this validation effort...Washington DC 20301 92-06991 AVF Control Number: AVF-VSR-511.0292 18 February 1992 91-07-16- VRX Ada COMPILER VALIDATION SUMMARY REPORT: Certificate Number...System: Ironics IV9001 board (AMD 29000) (Am29000 bare VME machine) Customer Agreement Number: 91-07-16- VRX See section 3.1 for any additional information

ART/Ada design project, phase 1. Task 3 report: Test plan

NASA Technical Reports Server (NTRS)

Allen, Bradley P.

1988-01-01

The plan is described for the integrated testing and benchmark of Phase Ada based ESBT Design Research Project. The integration testing is divided into two phases: (1) the modules that do not rely on the Ada code generated by the Ada Generator are tested before the Ada Generator is implemented; and (2) all modules are integrated and tested with the Ada code generated by the Ada Generator. Its performance and size as well as its functionality is verified in this phase. The target platform is a DEC Ada compiler on VAX mini-computers and VAX stations running the VMS operating system.

Trigger and data acquisition system for the N- N experiment

DOE Office of Scientific and Technical Information (OSTI.GOV)

Baldo-Ceolin, M.; Bobisut, F.; Bonaiti, V.

1991-04-01

In this paper the Trigger and Data Acquisition system of the N-{bar N} experiment at the Institute Laue-Langevin at Grenoble is presented, together with CAMAC modules especially designed for this experiment. The trigger system is organized on three logical levels; it works in the presence of a high level of beam induced noise, without beam pulse synchronization, looking for a very rare signal. The data acquisition is based on a MicroVax II computer, in a cluster with 4 VaxStations, the DAQP software developed at CERN. The system has been working for a year with high efficiency and reliability.

Ada Compiler Validation Summary Report: Certificate Number: 910626S1. 11174 U.S. Navy, Ada/M, Version 4.0 (/Optimize), VAX 8550, Running VAX/VMS version 5.3 (Host) to AN/UYK-44 (EMR) (Bare Board) (Target).

DTIC Science & Technology

1991-07-30

Gaithersburg, MD USA 7 PERFORMING ORGANIZATION NAME(S) AND ADDRESS(ES) 8. PERFORMING ORGANIZATION National Institute of Standards and Technology REPORT...Ada Compiler Validation Capability (ACVC). This Validation Summary Report ( VSR ) gives an account of the testing of this Ada implementation. For any... 7 => 𔃺’) & "F.E:" $MAXSTRINGLITERAL ’"’ & (1..V-2 => ’A’) & ’"’ A-i The fo~te1-wing table contains the values for the remaining macro parameters

Goldstone R/D High Speed Data Acquisition System

NASA Technical Reports Server (NTRS)

Deutsch, L. J.; Jurgens, R. F.; Brokl, S. S.

1984-01-01

A digital data acquisition system that meets the requirements of several users (initially the planetary radar program) is planned for general use at Deep Space Station 14 (DSS 14). The system, now partially complete, is controlled by VAX 11/780 computer that is programmed in high level languages. A DEC Data Controller is included for moderate-speed data acquisition, low speed data display, and for a digital interface to special user-provided devices. The high-speed data acquisition is performed in devices that are being designed and built at JPL. Analog IF signals are converted to a digitized 50 MHz real signal. This signal is filtered and mixed digitally to baseband after which its phase code (a PN sequence in the case of planetary radar) is removed. It may then be accumulated (or averaged) and fed into the VAX through an FPS 5210 array processor. Further data processing before entering the VAX is thus possible (computation and accumulation of the power spectra, for example). The system is to be located in the research and development pedestal at DSS 14 for easy access by researchers in radio astronomy as well as telemetry processing and antenna arraying.

The Vote and Vax program: public health at polling places.

PubMed

Shenson, Douglas; Adams, Mary

2008-01-01

Although influenza-associated illness is a major cause of hospitalizations and death among older Americans, only half of adults aged 50 or older-for whom influenza vaccinations are recommended-receive an annual influenza vaccination. National elections, which draw a large number of older voters, take place during influenza vaccination season and represent an untapped opportunity for large-scale delivery of vaccinations. In 2006, the Robert Wood Johnson Foundation launched a program to evaluate the feasibility of delivering influenza vaccinations near polling places. Twenty-five public health agencies were each provided grants of $8000 and asked to implement at least two Vote and Vax clinics. Immunizers were required to obtain prior permission from local election authorities and to charge fees as they would at their other community-based clinics. Influenza vaccination had to be made available both to voters and to nonvoters. On election day, the initiative delivered 13790 influenza vaccinations at 127 polling places in 14 states. More than 80 percent of adult vaccine recipients were in the Centers for Disease Prevention and Control-defined priority groups and 28 percent were "new" influenza vaccination recipients. Vote and Vax is a potentially national strategy that could significantly expand the delivery of influenza vaccinations.

Malaria diagnosis under field conditions in the Venezuelan Amazon.

PubMed

Metzger, W G; Vivas-Martínez, S; Rodriguez, I; Gonçalves, J; Bongard, E; Fanello, C I; Vivas, L; Magris, M

2008-01-01

To improve practical, accurate diagnosis of malaria in the Amazon rainforest of Venezuela, two rapid diagnostic tests (RDT) (OptiMAL-IT) and FalciVax) and a laboratory light microscope, used in the field with a battery-operated head lamp as an external light source, were evaluated against the standard laboratory microscope procedure for malaria detection. One hundred and thirty-six Yanomami patients were studied for the presence of malaria parasites. Thirty-three patients (24%) were positive for malaria (Plasmodium falciparum, P. vivax, P. malariae). Twenty-one (64%) of the positive patients had <100 parasites/microl. Both RDTs showed poor sensitivity (24.2% for OptiMAL-IT) and 36.4% for FalciVax) but good specificity (99% both for OptiMAL-IT) and FalciVax). Field and laboratory microscopy showed sensitivities of 94% and 91%, respectively. The kappa coefficient was 0.90, indicating a high agreement between field and laboratory microscopy. We conclude that (i) adequate slide reading cannot be substituted by either of the two RDTs in the Venezuelan Amazon and (ii) the use of a light source such as that described above makes slide reading more feasible than hitherto in remote areas without electricity.

Machine characterization and benchmark performance prediction

NASA Technical Reports Server (NTRS)

Saavedra-Barrera, Rafael H.

1988-01-01

From runs of standard benchmarks or benchmark suites, it is not possible to characterize the machine nor to predict the run time of other benchmarks which have not been run. A new approach to benchmarking and machine characterization is reported. The creation and use of a machine analyzer is described, which measures the performance of a given machine on FORTRAN source language constructs. The machine analyzer yields a set of parameters which characterize the machine and spotlight its strong and weak points. Also described is a program analyzer, which analyzes FORTRAN programs and determines the frequency of execution of each of the same set of source language operations. It is then shown that by combining a machine characterization and a program characterization, we are able to predict with good accuracy the run time of a given benchmark on a given machine. Characterizations are provided for the Cray-X-MP/48, Cyber 205, IBM 3090/200, Amdahl 5840, Convex C-1, VAX 8600, VAX 11/785, VAX 11/780, SUN 3/50, and IBM RT-PC/125, and for the following benchmark programs or suites: Los Alamos (BMK8A1), Baskett, Linpack, Livermore Loops, Madelbrot Set, NAS Kernels, Shell Sort, Smith, Whetstone and Sieve of Erathostenes.

Auditory backup alarms: distance-at-first-detection via in-situ experimentation on alarm design and hearing protection effects.

PubMed

Alali, Khaled; Casali, John G

2012-01-01

The purpose of this study was to assess normal hearing listeners' performance in detecting a stationary backup alarm signal and to quantify the linear distance at detection point. Detection distances for 12 participants with normal hearing were measured while they were fitted with 7 hearing protectors and while they were unoccluded (open ear). A standard (narrowband) backup alarm signal and a broadband (pulsed white noise) backup alarm signal from Brigade[1] were used. The method of limits, with distance as the physical measurement variable and threshold detection as the task, was employed to find at which distance the participant could first detect the backup alarms. A within-subject Analysis of Variance (ANOVA) revealed a significant main effect of the listening conditions on the detection distance in feet. Post hoc analyses indicated that the Bilsom L3HV conventional passive earmuff (at 1132.2 ft detection distance) was significantly poorer compared to all other HPDs and the open ear in detection distance achieved, and that there were no statistically-significant differences between the unoccluded ear (1652.3 ft), EB-15-Lo BlastPLGTM (1546.2 ft), EB-15-Hi BlastPLGTM (1543.4 ft), E-A-R/3M Combat ArmsTM earplug-nonlinear, level-dependent state (1507.8 ft), E-A-R/3M HiFiTM earplug (1497.7 ft), and Bilsom ImpactTM dichotic electronic earmuff (1567.2 ft). In addition, the E-A-R/3M Combat ArmsTM earplug-passive steady state resulted in significantly longer detection distances than only the open ear condition, at 1474.1 ft versus 1652.3 ft for the open ear. ANOVA also revealed a significant main effect of the backup alarm type on detection distance. The means were 1600.9 ft for the standard (narrowband) backup alarm signal, and a significantly closer 1379.4 ft was required for the Brigade broadband backup alarm signal. For on-ground workers, it is crucial to detect backup alarm signals as far away as possible rather than at close distances since this will provide them more time to react to approaching vehicles. The results of this study suggest that as the attenuation of the hearing protectors increases, precautions should be considered by safety professionals. This is because, as it was the case with the Bilsom passive earmuff and E-A-R/3M Combat ArmsTM earplug-passive steady state, high attenuation minimizes the detection distance and as a result on-foot workers will have less time to react to any approaching vehicle. The main effects of the type of backup alarm signal demonstrated a statistically-significant advantage of the standard backup alarm over the broadband backup alarm on detection distance in feet. The magnitude of the improvement produced by the standard backup alarm was 221.5 feet, a very large margin. For example, with a vehicle backing at 10 mph, the 221.5 ft decrease in detection distance with the Brigade alarm equates to the vehicle arriving 15 seconds sooner at the worker from the point at which its alarm was first heard.

Researching, Evaluating, and Choosing a Backup Service in the Cloud

ERIC Educational Resources Information Center

Hastings, Robin

2012-01-01

Backups are a modern fact of life. Every organization that has any kind of computing technology (and that is all of them these days) needs to back up its data in case of technological or user errors. Traditionally, large-scale backups have been done via an internal or external tape drive that takes magnetic tapes (minicassettes, essentially) and…

26 CFR 48.4082-4 - Diesel fuel and kerosene; back-up tax.

Code of Federal Regulations, 2011 CFR

2011-04-01

... 26 Internal Revenue 16 2011-04-01 2011-04-01 false Diesel fuel and kerosene; back-up tax. 48.4082..., and Taxable Fuel Taxable Fuel § 48.4082-4 Diesel fuel and kerosene; back-up tax. (a) Imposition of tax... fuel or kerosene on which tax has not been imposed by section 4081; (ii) Any diesel fuel or kerosene...

26 CFR 48.4082-4 - Diesel fuel and kerosene; back-up tax.

Code of Federal Regulations, 2012 CFR

2012-04-01

... 26 Internal Revenue 16 2012-04-01 2012-04-01 false Diesel fuel and kerosene; back-up tax. 48.4082..., and Taxable Fuel Taxable Fuel § 48.4082-4 Diesel fuel and kerosene; back-up tax. (a) Imposition of tax... fuel or kerosene on which tax has not been imposed by section 4081; (ii) Any diesel fuel or kerosene...

26 CFR 48.4082-4 - Diesel fuel and kerosene; back-up tax.

Code of Federal Regulations, 2013 CFR

2013-04-01

... 26 Internal Revenue 16 2013-04-01 2013-04-01 false Diesel fuel and kerosene; back-up tax. 48.4082..., and Taxable Fuel Taxable Fuel § 48.4082-4 Diesel fuel and kerosene; back-up tax. (a) Imposition of tax... fuel or kerosene on which tax has not been imposed by section 4081; (ii) Any diesel fuel or kerosene...

jsc2012e094947

NASA Image and Video Library

2012-06-20

At the Gagarin Cosmonaut Training Center in Star City, Russia, the Expedition 32/33 backup crew posed for pictures June 20, 2012 as they participated in the second of two days of Soyuz spacecraft qualification exams. Backup Flight Engineer Chris Hadfield of the Canadian Space Agency (left), backup Flight Engineer Tom Marshburn of NASA (center) and backup Soyuz Commander Roman Romanenko are understudies to the prime crew, NASA Flight Sunita Williams, Aki Hoshide of the Japan Aerospace Exploration Agency and Yuri Malenchenko, who will launch July 15 to the International Space Station in their Soyuz TMA-05M spacecraft from the Baikonur Cosmodrome in Kazakhstan. Credit: NASA/Stephanie Stoll

Improving the Quality of Backup Process for Publishing Houses and Printing Houses

NASA Astrophysics Data System (ADS)

Proskuriakov, N. E.; Yakovlev, B. S.; Pries, V. V.

2018-04-01

The analysis of main types for data threats, used by print media, and their influence on the vitality and security of information is made. The influence of the programs settings for preparing archive files, the types of file managers on the backup process is analysed. We proposed a simple and economical version of the practical implementation of the backup process consisting of 4 components: the command line interpreter, the 7z archiver, the Robocopy utility, and network storage. We recommend that the best option would be to create backup copies, consisting of three local copies of data and two network copies.

Visibility of children behind 2010-2013 model year passenger vehicles using glances, mirrors, and backup cameras and parking sensors.

PubMed

Kidd, David G; Brethwaite, Andrew

2014-05-01

This study identified the areas behind vehicles where younger and older children are not visible and measured the extent to which vehicle technologies improve visibility. Rear visibility of targets simulating the heights of a 12-15-month-old, a 30-36-month-old, and a 60-72-month-old child was assessed in 21 2010-2013 model year passenger vehicles with a backup camera or a backup camera plus parking sensor system. The average blind zone for a 12-15-month-old was twice as large as it was for a 60-72-month-old. Large SUVs had the worst rear visibility and small cars had the best. Increases in rear visibility provided by backup cameras were larger than the non-visible areas detected by parking sensors, but parking sensors detected objects in areas near the rear of the vehicle that were not visible in the camera or other fields of view. Overall, backup cameras and backup cameras plus parking sensors reduced the blind zone by around 90 percent on average and have the potential to prevent backover crashes if drivers use the technology appropriately. Copyright © 2014 Elsevier Ltd. All rights reserved.

Production planning and backup sourcing strategy of a buyer-dominant supply chain with random yield and demand

NASA Astrophysics Data System (ADS)

Chen, Kebing; Xiao, Tiaojun

2015-11-01

This paper studies the backup sourcing strategy of the buyer and the production planning of the supplier in presence of both random yield and random demand. Since the production is susceptible to the randomness of yield beyond the control of the supplier, the buyer may access to a backup sourcing option for the finished items. We analyse the value of backup sourcing for both the decentralised and centralised channels. Backup sourcing strategy of the buyer may lower the supply chain's performance. We show that the order quantity of the buyer does not change the stocking factor of the supplier's input. Meanwhile, compared with the centralised operation, the decentralised operation is more dependent on the backup sourcing to reduce supply shortage of the contracting supplier. From the channel's perspective, an incentive scheme is developed to facilitate the coordination of both the buyer and the contracting supplier, we show that the proposed option contract can allow the supply chain members to share the respective risks involved in the production and selling processes. Finally, we also provide qualitative insights based on numerical examples of the centralised and decentralised solutions.

CUTSETS - MINIMAL CUT SET CALCULATION FOR DIGRAPH AND FAULT TREE RELIABILITY MODELS

NASA Technical Reports Server (NTRS)

Iverson, D. L.

1994-01-01

Fault tree and digraph models are frequently used for system failure analysis. Both type of models represent a failure space view of the system using AND and OR nodes in a directed graph structure. Fault trees must have a tree structure and do not allow cycles or loops in the graph. Digraphs allow any pattern of interconnection between loops in the graphs. A common operation performed on digraph and fault tree models is the calculation of minimal cut sets. A cut set is a set of basic failures that could cause a given target failure event to occur. A minimal cut set for a target event node in a fault tree or digraph is any cut set for the node with the property that if any one of the failures in the set is removed, the occurrence of the other failures in the set will not cause the target failure event. CUTSETS will identify all the minimal cut sets for a given node. The CUTSETS package contains programs that solve for minimal cut sets of fault trees and digraphs using object-oriented programming techniques. These cut set codes can be used to solve graph models for reliability analysis and identify potential single point failures in a modeled system. The fault tree minimal cut set code reads in a fault tree model input file with each node listed in a text format. In the input file the user specifies a top node of the fault tree and a maximum cut set size to be calculated. CUTSETS will find minimal sets of basic events which would cause the failure at the output of a given fault tree gate. The program can find all the minimal cut sets of a node, or minimal cut sets up to a specified size. The algorithm performs a recursive top down parse of the fault tree, starting at the specified top node, and combines the cut sets of each child node into sets of basic event failures that would cause the failure event at the output of that gate. Minimal cut set solutions can be found for all nodes in the fault tree or just for the top node. The digraph cut set code uses the same techniques as the fault tree cut set code, except it includes all upstream digraph nodes in the cut sets for a given node and checks for cycles in the digraph during the solution process. CUTSETS solves for specified nodes and will not automatically solve for all upstream digraph nodes. The cut sets will be output as a text file. CUTSETS includes a utility program that will convert the popular COD format digraph model description files into text input files suitable for use with the CUTSETS programs. FEAT (MSC-21873) and FIRM (MSC-21860) available from COSMIC are examples of programs that produce COD format digraph model description files that may be converted for use with the CUTSETS programs. CUTSETS is written in C-language to be machine independent. It has been successfully implemented on a Sun running SunOS, a DECstation running ULTRIX, a Macintosh running System 7, and a DEC VAX running VMS. The RAM requirement varies with the size of the models. CUTSETS is available in UNIX tar format on a .25 inch streaming magnetic tape cartridge (standard distribution) or on a 3.5 inch diskette. It is also available on a 3.5 inch Macintosh format diskette or on a 9-track 1600 BPI magnetic tape in DEC VAX FILES-11 format. Sample input and sample output are provided on the distribution medium. An electronic copy of the documentation in Macintosh Microsoft Word format is included on the distribution medium. Sun and SunOS are trademarks of Sun Microsystems, Inc. DEC, DeCstation, ULTRIX, VAX, and VMS are trademarks of Digital Equipment Corporation. UNIX is a registered trademark of AT&T Bell Laboratories. Macintosh is a registered trademark of Apple Computer, Inc.

hSMR3A as a Marker for Patients With Erectile Dysfunction

PubMed Central

Tong, Yuehong; Tar, Moses; Monrose, Val; DiSanto, Michael; Melman, Arnold; Davies, Kelvin P.

2007-01-01

Purpose We recently reported that Vcsa1 is one of the most down-regulated genes in the corpora of rats in 3 distinct models of erectile dysfunction. Since gene transfer of plasmids expressing Vcsa1 or intracorporeal injection of its mature peptide product sialorphin into the corpora of aging rats was shown to restore erectile function, we proposed that the Vcsa1 gene has a direct role in erectile function. To determine if similar changes in gene expression occur in the corpora of human subjects with erectile dysfunction we identified a human homologue of Vcsa1 (hSMR3A) and determined the level of expression of hSMR3A in patients. Materials and Methods hSMR3A was identified as a homologue of Vcsa1 by searching protein databases for proteins with similarity. hSMR3A cDNA was generated and subcloned into the plasmid pVAX to generate pVAX-hSMR3A. pVAX-hSMR3A (25 or 100 μg) was intracorporeally injected into aging rats. The effect on erectile physiology was compared histologically and by measuring intracorporeal pressure/blood pressure with controls treated with the empty plasmid pVAX. Total RNA was extracted from human corporeal tissue obtained from patients undergoing previously scheduled penile surgery. Patients were grouped according to normal erectile function (3), erectile dysfunction and diabetes (5) and patients without diabetes but with erectile dysfunction (5). Quantitative reverse-transcriptase polymerase chain reaction was used to determine the hSMR3A expression level. Results Intracorporeal injection of 25 μg pVAX-hSMR3A was able to significantly increase the intracorporeal pressure-to-blood pressure ratio in aging rats compared to age matched controls. Higher amounts (100 μg) of gene transfer of the plasmid caused less of an improvement in the intracorporeal pressure-to-blood pressure ratio compared to controls, although there was histological and visual evidence that the animals were post-priapitic. These physiological effects were similar to previously reported effects of intracorporeal injection of pVAX-Vcsa1 into the corpora of aging rats, establishing hSMR3A as a functional homologue of Vcsa1. More than 10-fold down-regulation in hSMR3A transcript expression was observed in the corpora of patients with vs without erectile dysfunction. In patients with diabetes associated and nondiabetes associated erectile dysfunction hSMR3A expression was found to be down-regulated. Conclusions These results suggest that hSMR3A can act as a marker for erectile dysfunction associated with diabetic and nondiabetic etiologies. Given that our previous studies demonstrated that gene transfer of the Vcsa1 gene and intracorporeal injection of its protein product in rats can restore erectile function, these results suggest that therapies that increase the hSMR3A gene and product expression could potentially have a positive impact on erectile function. PMID:17512016

hSMR3A as a marker for patients with erectile dysfunction.

PubMed

Tong, Yuehong; Tar, Moses; Monrose, Val; DiSanto, Michael; Melman, Arnold; Davies, Kelvin P

2007-07-01

We recently reported that Vcsa1 is one of the most down-regulated genes in the corpora of rats in 3 distinct models of erectile dysfunction. Since gene transfer of plasmids expressing Vcsa1 or intracorporeal injection of its mature peptide product sialorphin into the corpora of aging rats was shown to restore erectile function, we proposed that the Vcsa1 gene has a direct role in erectile function. To determine if similar changes in gene expression occur in the corpora of human subjects with erectile dysfunction we identified a human homologue of Vcsa1 (hSMR3A) and determined the level of expression of hSMR3A in patients. hSMR3A was identified as a homologue of Vcsa1 by searching protein databases for proteins with similarity. hSMR3A cDNA was generated and subcloned into the plasmid pVAX to generate pVAX-hSMR3A. pVAX-hSMR3A (25 or 100 microg) was intracorporeally injected into aging rats. The effect on erectile physiology was compared histologically and by measuring intracorporeal pressure/blood pressure with controls treated with the empty plasmid pVAX. Total RNA was extracted from human corporeal tissue obtained from patients undergoing previously scheduled penile surgery. Patients were grouped according to normal erectile function (3), erectile dysfunction and diabetes (5) and patients without diabetes but with erectile dysfunction (5). Quantitative reverse-transcriptase polymerase chain reaction was used to determine the hSMR3A expression level. Intracorporeal injection of 25 microg pVAX-hSMR3A was able to significantly increase the intracorporeal pressure-to-blood pressure ratio in aging rats compared to age matched controls. Higher amounts (100 microg) of gene transfer of the plasmid caused less of an improvement in the intracorporeal pressure-to-blood pressure ratio compared to controls, although there was histological and visual evidence that the animals were post-priapitic. These physiological effects were similar to previously reported effects of intracorporeal injection of pVAX-Vcsa1 into the corpora of aging rats, establishing hSMR3A as a functional homologue of Vcsa1. More than 10-fold down-regulation in hSMR3A transcript expression was observed in the corpora of patients with vs without erectile dysfunction. In patients with diabetes associated and nondiabetes associated erectile dysfunction hSMR3A expression was found to be down-regulated. These results suggest that hSMR3A can act as a marker for erectile dysfunction associated with diabetic and nondiabetic etiologies. Given that our previous studies demonstrated that gene transfer of the Vcsa1 gene and intracorporeal injection of its protein product in rats can restore erectile function, these results suggest that therapies that increase the hSMR3A gene and product expression could potentially have a positive impact on erectile function.

Back-Up Childcare: A Quality Alternative to Regular Care Which Fosters Resilience in Infants and Toddlers.

ERIC Educational Resources Information Center

La Bar, Nicole J.

To many in the field of early care and education, back-up child care may be viewed as a stressful disruption that could interfere with attachment and be detrimental to continuity of care. This paper attempts to prove that high-quality back-up child care offered by employers actually fosters the development of resiliency in young children by…

26 CFR 48.4082-4 - Diesel fuel and kerosene; back-up tax.

Code of Federal Regulations, 2010 CFR

2010-04-01

... 26 Internal Revenue 16 2010-04-01 2010-04-01 true Diesel fuel and kerosene; back-up tax. 48.4082-4..., and Taxable Fuel Taxable Fuel § 48.4082-4 Diesel fuel and kerosene; back-up tax. (a) Imposition of tax... fuel or kerosene on which tax has not been imposed by section 4081; (ii) Any diesel fuel or kerosene...

Independent backup mode transfer and mechanism for digital control computers

NASA Technical Reports Server (NTRS)

Tulpule, Bhalchandra R. (Inventor); Oscarson, Edward M. (Inventor)

1992-01-01

An interrupt is provided to a signal processor having a non-maskable interrupt input, in response to the detection of a request for transfer to backup software. The signal processor provides a transfer signal to a transfer mechanism only after completion of the present machine cycle. Transfer to the backup software is initiated by the transfer mechanism only upon reception of the transfer signal.

Clinical experiences with an ASP model backup archive for PACS images

NASA Astrophysics Data System (ADS)

Liu, Brent J.; Cao, Fei; Documet, Luis; Huang, H. K.; Muldoon, Jean

2003-05-01

Last year we presented a Fault-Tolerant Backup Archive using an Application Service Provider (ASP) model for disaster recovery. The purpose of this paper is to update and provide clinical experiences related towards implementing the ASP model archive solution for short-term backup of clinical PACS image data as well as possible applications other than disaster recovery. The ASP backup archive provides instantaneous, automatic backup of acquired PACS image data and instantaneous recovery of stored PACS image data all at a low operational cost and with little human intervention. This solution can be used for a variety of scheduled and unscheduled downtimes that occur on the main PACS archive. A backup archive server with hierarchical storage was implemented offsite from the main PACS archive location. Clinical data from a hospital PACS is sent to this ASP storage server in parallel to the exams being archived in the main server. Initially, connectivity between the main archive and the ASP storage server is established via a T-1 connection. In the future, other more cost-effective means of connectivity will be researched such as the Internet 2. We have integrated the ASP model backup archive with a clinical PACS at Saint John's Health Center and has been operational for over 6 months. Pitfalls encountered during integration with a live clinical PACS and the impact to clinical workflow will be discussed. In addition, estimations of the cost of establishing such a solution as well as the cost charged to the users will be included. Clinical downtime scenarios, such as a scheduled mandatory downtime and an unscheduled downtime due to a disaster event to the main archive, were simulated and the PACS exams were sent successfully from the offsite ASP storage server back to the hospital PACS in less than 1 day. The ASP backup archive was able to recover PACS image data for comparison studies with no complex operational procedures. Furthermore, no image data loss was encountered during the recovery. During any clinical downtime scenario, the ASP backup archive server can repopulate a clinical PACS quickly with the majority of studies available for comparison during the interim until the main PACS archive is fully recovered.

Enhanced method of fast re-routing with load balancing in software-defined networks

NASA Astrophysics Data System (ADS)

Lemeshko, Oleksandr; Yeremenko, Oleksandra

2017-11-01

A two-level method of fast re-routing with load balancing in a software-defined network (SDN) is proposed. The novelty of the method consists, firstly, in the introduction of a two-level hierarchy of calculating the routing variables responsible for the formation of the primary and backup paths, and secondly, in ensuring a balanced load of the communication links of the network, which meets the requirements of the traffic engineering concept. The method provides implementation of link, node, path, and bandwidth protection schemes for fast re-routing in SDN. The separation in accordance with the interaction prediction principle along two hierarchical levels of the calculation functions of the primary (lower level) and backup (upper level) routes allowed to abandon the initial sufficiently large and nonlinear optimization problem by transiting to the iterative solution of linear optimization problems of half the dimension. The analysis of the proposed method confirmed its efficiency and effectiveness in terms of obtaining optimal solutions for ensuring balanced load of communication links and implementing the required network element protection schemes for fast re-routing in SDN.

FPT- FORTRAN PROGRAMMING TOOLS FOR THE DEC VAX

NASA Technical Reports Server (NTRS)

Ragosta, A. E.

1994-01-01

The FORTRAN Programming Tools (FPT) are a series of tools used to support the development and maintenance of FORTRAN 77 source codes. Included are a debugging aid, a CPU time monitoring program, source code maintenance aids, print utilities, and a library of useful, well-documented programs. These tools assist in reducing development time and encouraging high quality programming. Although intended primarily for FORTRAN programmers, some of the tools can be used on data files and other programming languages. BUGOUT is a series of FPT programs that have proven very useful in debugging a particular kind of error and in optimizing CPU-intensive codes. The particular type of error is the illegal addressing of data or code as a result of subtle FORTRAN errors that are not caught by the compiler or at run time. A TRACE option also allows the programmer to verify the execution path of a program. The TIME option assists the programmer in identifying the CPU-intensive routines in a program to aid in optimization studies. Program coding, maintenance, and print aids available in FPT include: routines for building standard format subprogram stubs; cleaning up common blocks and NAMELISTs; removing all characters after column 72; displaying two files side by side on a VT-100 terminal; creating a neat listing of a FORTRAN source code including a Table of Contents, an Index, and Page Headings; converting files between VMS internal format and standard carriage control format; changing text strings in a file without using EDT; and replacing tab characters with spaces. The library of useful, documented programs includes the following: time and date routines; a string categorization routine; routines for converting between decimal, hex, and octal; routines to delay process execution for a specified time; a Gaussian elimination routine for solving a set of simultaneous linear equations; a curve fitting routine for least squares fit to polynomial, exponential, and sinusoidal forms (with a screen-oriented editor); a cubic spline fit routine; a screen-oriented array editor; routines to support parsing; and various terminal support routines. These FORTRAN programming tools are written in FORTRAN 77 and ASSEMBLER for interactive and batch execution. FPT is intended for implementation on DEC VAX series computers operating under VMS. This collection of tools was developed in 1985.

jsc2013e048273

NASA Image and Video Library

2013-05-22

Behind the Cosmonaut Hotel crew quarters in Baikonur, Kazakhstan, the Expedition 36/37 backup and prime crewmembers pose for pictures in front of a Proton rocket statue May 22 following traditional ceremonies. From left to right are backup Flight Engineer Koichi Wakata of the Japan Aerospace Exploration Agency, backup Soyuz Commander Mikhail Tyurin, backup Flight Engineer Rick Mastracchio of NASA, prime Flight Engineer Karen Nyberg of NASA, prime Soyuz Commander Fyodor Yurchikhin and prime Flight Engineer Luca Parmitano of the European Space Agency. Nyberg, Yurchikhin and Parmitano are preparing for their launch May 29, Kazakh time, in the Soyuz TMA-09M spacecraft to begin a 5 ½ month mission on the International Space Station. NASA/Victor Zelentsov

Mechanization of and experience with a triplex fly-by-wire backup control system

NASA Technical Reports Server (NTRS)

Lock, W. P.; Petersen, W. R.; Whitman, G. B.

1975-01-01

A redundant three-axis analog control system was designed and developed to back up a digital fly-by-wire control system for an F-8C airplane. Forty-two flights, involving 58 hours of flight time, were flown by six pilots. The mechanization and operational experience with the backup control system, the problems involved in synchronizing it with the primary system, and the reliability of the system are discussed. The backup control system was dissimilar to the primary system, and it provided satisfactory handling through the flight envelope evaluated. Limited flight tests of a variety of control tasks showed that control was also satisfactory when the backup control system was controlled by a minimum-displacement (force) side stick. The operational reliability of the F-8 digital fly-by-wire control system was satisfactory, with no unintentional downmodes to the backup control system in flight. The ground and flight reliability of the system's components is discussed.

Implementation of an ASP model offsite backup archive for clinical images utilizing Internet 2

NASA Astrophysics Data System (ADS)

Liu, Brent J.; Chao, Sander S.; Documet, Jorge; Lee, Jasper; Lee, Michael; Topic, Ian; Williams, Lanita

2005-04-01

With the development of PACS technology and an increasing demand by medical facilities to become filmless, there is a need for a fast and efficient method of providing data backup for disaster recovery and downtime scenarios. At the Image Processing Informatics Lab (IPI), an ASP Backup Archive was developed using a fault-tolerant server with a T1 connection to serve the PACS at the St. John's Health Center (SJHC) Santa Monica, California. The ASP archive server has been in clinical operation for more than 18 months, and its performance was presented at this SPIE Conference last year. This paper extends the ASP Backup Archive to serve the PACS at the USC Healthcare Consultation Center II (HCC2) utilizing an Internet2 connection. HCC2 is a new outpatient facility that recently opened in April 2004. The Internet2 connectivity between USC's HCC2 and IPI has been established for over one year. There are two novelties of the current ASP model: 1) Use of Internet2 for daily clinical operation, and 2) Modifying the existing backup archive to handle two sites in the ASP model. This paper presents the evaluation of the ASP Backup Archive based on the following two criteria: 1) Reliability and performance of the Internet2 connection between HCC2 and IPI using DICOM image transfer in a clinical environment, and 2) Ability of the ASP Fault-Tolerant backup archive to support two separate clinical PACS sites simultaneously. The performances of using T1 and Internet2 at the two different sites are also compared.

Lithology and aggregate quality attributes for the digital geologic map of Colorado

USGS Publications Warehouse

Knepper, Daniel H.; Green, Gregory N.; Langer, William H.

1999-01-01

This geologic map was prepared as a part of a study of digital methods and techniques as applied to complex geologic maps. The geologic map was digitized from the original scribe sheets used to prepare the published Geologic Map of Colorado (Tweto 1979). Consequently the digital version is at 1:500,000 scale using the Lambert Conformal Conic map projection parameters of the state base map. Stable base contact prints of the scribe sheets were scanned on a Tektronix 4991 digital scanner. The scanner automatically converts the scanned image to an ASCII vector format. These vectors were transferred to a VAX minicomputer, where they were then loaded into ARC/INFO. Each vector and polygon was given attributes derived from the original 1979 geologic map.

PAWS/STEM - PADE APPROXIMATION WITH SCALING AND SCALED TAYLOR EXPONENTIAL MATRIX (VAX VMS VERSION)

NASA Technical Reports Server (NTRS)

Butler, R. W.

1994-01-01

Traditional fault-tree techniques for analyzing the reliability of large, complex systems fail to model the dynamic reconfiguration capabilities of modern computer systems. Markov models, on the other hand, can describe fault-recovery (via system reconfiguration) as well as fault-occurrence. The Pade Approximation with Scaling (PAWS) and Scaled Taylor Exponential Matrix (STEM) programs provide a flexible, user-friendly, language-based interface for the creation and evaluation of Markov models describing the behavior of fault-tolerant reconfigurable computer systems. PAWS and STEM produce exact solutions for the probability of system failure and provide a conservative estimate of the number of significant digits in the solution. The calculation of the probability of entering a death state of a Markov model (representing system failure) requires the solution of a set of coupled differential equations. Because of the large disparity between the rates of fault arrivals and system recoveries, Markov models of fault-tolerant architectures inevitably lead to numerically stiff differential equations. Both PAWS and STEM have the capability to solve numerically stiff models. These complementary programs use separate methods to determine the matrix exponential in the solution of the model's system of differential equations. In general, PAWS is better suited to evaluate small and dense models. STEM operates at lower precision, but works faster than PAWS for larger models. The mathematical approach chosen to solve a reliability problem may vary with the size and nature of the problem. Although different solution techniques are utilized on different programs, it is possible to have a common input language. The Systems Validation Methods group at NASA Langley Research Center has created a set of programs that form the basis for a reliability analysis workstation. The set of programs are: SURE reliability analysis program (COSMIC program LAR-13789, LAR-14921); the ASSIST specification interface program (LAR-14193, LAR-14923), PAWS/STEM reliability analysis programs (LAR-14165, LAR-14920); and the FTC fault tree tool (LAR-14586, LAR-14922). FTC is used to calculate the top-event probability for a fault tree. PAWS/STEM and SURE are programs which interpret the same SURE language, but utilize different solution methods. ASSIST is a preprocessor that generates SURE language from a more abstract definition. SURE, ASSIST, and PAWS/STEM are also offered as a bundle. Please see the abstract for COS-10039/COS-10041, SARA - SURE/ASSIST Reliability Analysis Workstation, for pricing details. PAWS/STEM was originally developed for DEC VAX series computers running VMS and was later ported for use on Sun computers running SunOS. The package is written in PASCAL, ANSI compliant C-language, and FORTRAN 77. The standard distribution medium for the VMS version of PAWS/STEM (LAR-14165) is a 9-track 1600 BPI magnetic tape in VMSINSTAL format. It is also available on a TK50 tape cartridge in VMSINSTAL format. Executables are included. The standard distribution medium for the Sun version of PAWS/STEM (LAR-14920) is a .25 inch streaming magnetic tape cartridge in UNIX tar format. Both Sun3 and Sun4 executables are included. PAWS/STEM was developed in 1989 and last updated in 1991. DEC, VAX, VMS, and TK50 are trademarks of Digital Equipment Corporation. SunOS, Sun3, and Sun4 are trademarks of Sun Microsystems, Inc. UNIX is a registered trademark of AT&T Bell Laboratories.

Emergency and backup power supplies at Department of Energy facilities: Augmented Evaluation Team -- Final report

DOE Office of Scientific and Technical Information (OSTI.GOV)

Not Available

This report documents the results of the Defense Programs (DP) Augmented Evaluation Team (AET) review of emergency and backup power supplies (i.e., generator, uninterruptible power supply, and battery systems) at DP facilities. The review was conducted in response to concerns expressed by former Secretary of Energy James D. Watkins over the number of incidents where backup power sources failed to provide electrical power during tests or actual demands. The AET conducted a series of on-site reviews for the purpose of understanding the design, operation, maintenance, and safety significance of emergency and backup power (E&BP) supplies. The AET found that themore » quality of programs related to maintenance of backup power systems varies greatly among the sites visited, and often among facilities at the same site. No major safety issues were identified. However, there are areas where the AET believes the reliability of emergency and backup power systems can and should be improved. Recommendations for improving the performance of E&BP systems are provided in this report. The report also discusses progress made by Management and Operating (M&O) contractors to improve the reliability of backup sources used in safety significant applications. One area that requires further attention is the analysis and understanding of the safety implications of backup power equipment. This understanding is needed for proper graded-approach implementation of Department of Energy (DOE) Orders, and to help ensure that equipment important to the safety of DOE workers, the public, and the environment is identified, classified, recognized, and treated as such by designers, users, and maintainers. Another area considered important for improving E&BP system performance is the assignment of overall ownership responsibility and authority for ensuring that E&BP equipment performs adequately and that reliability and availability are maintained at acceptable levels.« less

A VLSI VAX chip set

NASA Astrophysics Data System (ADS)

Johnson, W. N.; Herrick, W. V.; Grundmann, W. J.

1984-10-01

For the first time, VLSI technology is used to compress the full functinality and comparable performance of the VAX 11/780 super-minicomputer into a 1.2 M transistor microprocessor chip set. There was no subsetting of the 304 instruction set and the 17 data types, nor reduction in hardware support for the 4 Gbyte virtual memory management architecture. The chipset supports an integral 8 kbyte memory cache, a 13.3 Mbyte/s system bus, and sophisticated multiprocessing. High performance is achieved through microcode optimizations afforded by the large control store, tightly coupled address and data caches, the use of internal and external 32 bit datapaths, the extensive aplication of both microlevel and macrolevel pipelining, and the use of specialized hardware assists.

APOLLO-SOYUZ TEST PROJECT (ASTP) - CREWMEN - JSC

NASA Image and Video Library

1975-07-09

S75-28361 (9 July 1975) --- These ten American astronauts compose the U.S. prime crew, the backup crew and the crew support team for the joint U.S.-USSR Apollo-Soyuz Test Project docking mission in Earth orbit. They are, left to right, Robert L. Crippen, support team; Robert F. Overmyer, support team; Richard H. Truly, support team; Karol J. Bobko, support team; Donald K. Slayton, prime crew docking module pilot; Thomas P. Stafford, prime crew commander; Vance D. Brand, prime crew command module pilot; Jack R. Lousma, backup crew docking module pilot; Ronald E. Evans, backup crew command module pilot; and Alan L. Bean, backup crew commander. They are photographed by the Apollo Mission Simulator console in Building 5 at NASA's Johnson Space Center.

jsc2012e051224

NASA Image and Video Library

2012-05-09

In the town of Baikonur, Kazakhstan, the Expedition 31/32 backup crew participated in Victory Day celebration activities May 9, 2012 as they took a break from training for the launch of the Soyuz TMA-04M May 15 to the International Space Station. Victory Day commemorates the triumph of Russia over Nazi Germany in World War II, one of Russia’s most solemn occasions. From left to right holding flowers are backup NASA Flight Engineer Kevin Ford, backup Soyuz Commander Oleg Novitskiy and backup Flight Engineer Evgeny Tarelkin. The prime crew, Gennady Padalka, Sergei Revin and NASA’s Joe Acaba, are training for their launch in the Soyuz vehicle on May 15 for a four-month mission on the orbital complex. NASA/Victor Zelentsov

jsc2012e051223

NASA Image and Video Library

2012-05-09

In the town of Baikonur, Kazakhstan, the Expedition 31/32 backup crew participated in Victory Day celebration activities May 9, 2012 as they took a break from training for the launch of the Soyuz TMA-04M May 15 to the International Space Station. Victory Day commemorates the triumph of Russia over Nazi Germany in World War II, one of Russia’s most solemn occasions. From left to right holding flowers are backup NASA Flight Engineer Kevin Ford, backup Soyuz Commander Oleg Novitskiy and backup Flight Engineer Evgeny Tarelkin. The prime crew, Gennady Padalka, Sergei Revin and NASA’s Joe Acaba, are training for their launch in the Soyuz vehicle on May 15 for a four-month mission on the orbital complex. NASA/Victor Zelentsov

ZED- A LINE EDITOR FOR THE DEC VAX

NASA Technical Reports Server (NTRS)

Scott, P. J.

1994-01-01

The ZED editor for the DEC VAX is a simple, yet powerful line editor for text, program source code, and non-binary data. Line editors can be superior to screen editors in some cases, such as executing complex multiple or conditional commands, or editing via slow modem lines. ZED excels in the area of text processing by using procedure files. For example, such procedures can reformat a file of addresses or remove all comment lines from a FORTRAN program. In addition to command files, ZED also features versatile search qualifiers, global changes, conditionals, on-line help, hexadecimal mode, space compression, looping, logical combinations of search strings, journaling, visible control characters, and automatic detabbing. The ZED editor was originally developed at Cambridge University in London and has been continuously enhanced since 1976. Users of the Cambridge implementation have devised such elaborate ZED procedures as chess games, calculators, and programs for evaluating Pi. This implementation of ZED strives to maintain the characteristics of the Cambridge editor. A complete ZED manual is included on the tape. ZED is written entirely in C for either batch or interactive execution on the DEC VAX under VMS 4.X and requires 80,896 bytes of memory. This program was released in 1988 and updated in 1989.

DNA vaccine encoding central conserved region of G protein induces Th1 predominant immune response and protection from RSV infection in mice.

PubMed

Hua, Ying; Jiao, Yue-Ying; Ma, Yao; Peng, Xiang-Lei; Fu, Yuan-Hui; Zheng, Yan-Peng; Hong, Tao; He, Jin-Sheng

2016-11-01

Human respiratory syncytial virus (RSV) can cause serious infection in the lower respiratory tract, especially in infants, young children, the elderly and the immunocompromised population worldwide. Previous study demonstrated the polypeptide (amino acids 148-198) of RSV attachment (G) glycoprotein, corresponding to the central conserved region and encompassing CX3C chemokine motif, could induce antibodies and protection from RSV challenge in mice [1,2]. In this study, we evaluated the immune efficacy of the recombinant DNA vaccine of pVAX1/3G 148-198 encoding RSV G protein polypeptide. RSV specific serum IgG antibodies with neutralizing activity were stimulated following prime-boost immunization of pVAX1/3G 148-198 intramuscularly, and the ratio of IgG2a/IgG1 was 4.93, indicating a Th1 biased immune response. After challenged intranasally with RSV Long, the vaccinated mice showed both decreased lung RSV titers, pulmonary inflammation and body weight loss. The results suggest that pVAX1/3G 148-198 DNA vaccine may be an effective RSV vaccine candidate, and deserves further exploration. Copyright © 2016 European Federation of Immunological Societies. Published by Elsevier B.V. All rights reserved.

PCDS as a tool in teaching and research at the University of Michigan

NASA Technical Reports Server (NTRS)

Abreu, V.

1986-01-01

The Space Physics Research Laboratory's (SPRL) use of the Pilot Climate Data System (PCDS) is discussed. For this purpose, a computer center was established to provide the hardware and software necessary to fully utilize existing data bases for research and teaching purposes. A schematic of the SPRL network is given. The core of the system consists of two VAX 11/750s and a VAX 8600, networked through ETHERNET to several LSI 11/23 microprocessors. Much of the system is used for external communications with major networks and data centers. A VAX 11/750 provides DECNET services through the SPAN network to the PCDS. A functional diagram of PCDS usage is given. The browsing capabilities of the PCDS are used to generate data files, which are later transferred to the SPRL center for further data manipulation and display. This mode of operation for classroom instruction will be used to effectively use terminals and to simplify usage of the data base. The Atmosphere Explorer data base has been used successfully in a similar manner in courses related to the thermosphere and ionosphere. The main motivation to access the PCDS was to complement research efforts related to the High Resolution Doppler Imager (HRDI), to be flown on the Upper Atmosphere Research Satellite (UARS).

SAP- FORTRAN STATIC SOURCE CODE ANALYZER PROGRAM (DEC VAX VERSION)

NASA Technical Reports Server (NTRS)

Merwarth, P. D.

1994-01-01

The FORTRAN Static Source Code Analyzer program, SAP, was developed to automatically gather statistics on the occurrences of statements and structures within a FORTRAN program and to provide for the reporting of those statistics. Provisions have been made for weighting each statistic and to provide an overall figure of complexity. Statistics, as well as figures of complexity, are gathered on a module by module basis. Overall summed statistics are also accumulated for the complete input source file. SAP accepts as input syntactically correct FORTRAN source code written in the FORTRAN 77 standard language. In addition, code written using features in the following languages is also accepted: VAX-11 FORTRAN, IBM S/360 FORTRAN IV Level H Extended; and Structured FORTRAN. The SAP program utilizes two external files in its analysis procedure. A keyword file allows flexibility in classifying statements and in marking a statement as either executable or non-executable. A statistical weight file allows the user to assign weights to all output statistics, thus allowing the user flexibility in defining the figure of complexity. The SAP program is written in FORTRAN IV for batch execution and has been implemented on a DEC VAX series computer under VMS and on an IBM 370 series computer under MVS. The SAP program was developed in 1978 and last updated in 1985.

Direct adaptive control of a PUMA 560 industrial robot

NASA Technical Reports Server (NTRS)

Seraji, Homayoun; Lee, Thomas; Delpech, Michel

1989-01-01

The implementation and experimental validation of a new direct adaptive control scheme on a PUMA 560 industrial robot is described. The testbed facility consists of a Unimation PUMA 560 six-jointed robot and controller, and a DEC MicroVAX II computer which hosts the Robot Control C Library software. The control algorithm is implemented on the MicroVAX which acts as a digital controller for the PUMA robot, and the Unimation controller is effectively bypassed and used merely as an I/O device to interface the MicroVAX to the joint motors. The control algorithm for each robot joint consists of an auxiliary signal generated by a constant-gain Proportional plus Integral plus Derivative (PID) controller, and an adaptive position-velocity (PD) feedback controller with adjustable gains. The adaptive independent joint controllers compensate for the inter-joint couplings and achieve accurate trajectory tracking without the need for the complex dynamic model and parameter values of the robot. Extensive experimental results on PUMA joint control are presented to confirm the feasibility of the proposed scheme, in spite of strong interactions between joint motions. Experimental results validate the capabilities of the proposed control scheme. The control scheme is extremely simple and computationally very fast for concurrent processing with high sampling rates.

Preclinical and clinical development of a YFV 17 D-based chimeric vaccine against West Nile virus.

PubMed

Dayan, Gustavo H; Pugachev, Konstantin; Bevilacqua, Joan; Lang, Jean; Monath, Thomas P

2013-12-09

Substantial success has been achieved in the development and implementation of West Nile (WN) vaccines for horses; however, no human WN vaccines are approved. This review focuses on the construction, pre-clinical and clinical characterization of ChimeriVax-WN02 for humans, a live chimeric vaccine composed of a yellow fever (YF) 17D virus in which the prM-E envelope protein genes are replaced with the corresponding genes of the WN NY99 virus. Pre-clinical studies demonstrated that ChimeriVax-WN02 was significantly less neurovirulent than YF 17D in mice and rhesus and cynomolgus monkeys. The vaccine elicited neutralizing antibody titers after inoculation in hamsters and monkeys and protected immunized animals from lethal challenge including intracerebral inoculation of high dose of WN NY99 virus. Safety, viremia and immunogenicity of ChimeriVax-WN02 were assessed in one phase I study and in two phase II clinical trials. No safety signals were detected in the three clinical trials with no remarkable differences in incidence of adverse events (AEs) between vaccine and placebo recipients. Viremia was transient and the mean viremia levels were low. The vaccine elicited strong and durable neutralizing antibody and cytotoxic T cell responses. WN epidemiology impedes a classical licensure pathway; therefore, innovative licensure strategies should be explored.

KNET - DISTRIBUTED COMPUTING AND/OR DATA TRANSFER PROGRAM

NASA Technical Reports Server (NTRS)

Hui, J.

1994-01-01

KNET facilitates distributed computing between a UNIX compatible local host and a remote host which may or may not be UNIX compatible. It is capable of automatic remote login. That is, it performs on the user's behalf the chore of handling host selection, user name, and password to the designated host. Once the login has been successfully completed, the user may interactively communicate with the remote host. Data output from the remote host may be directed to the local screen, to a local file, and/or to a local process. Conversely, data input from the keyboard, a local file, or a local process may be directed to the remote host. KNET takes advantage of the multitasking and terminal mode control features of the UNIX operating system. A parent process is used as the upper layer for interfacing with the local user. A child process is used for a lower layer for interfacing with the remote host computer, and optionally one or more child processes can be used for the remote data output. Output may be directed to the screen and/or to the local processes under the control of a data pipe switch. In order for KNET to operate, the local and remote hosts must observe a common communications protocol. KNET is written in ANSI standard C-language for computers running UNIX. It has been successfully implemented on several Sun series computers and a DECstation 3100 and used to run programs remotely on VAX VMS and UNIX based computers. It requires 100K of RAM under SunOS and 120K of RAM under DEC RISC ULTRIX. An electronic copy of the documentation is provided on the distribution medium. The standard distribution medium for KNET is a .25 inch streaming magnetic tape cartridge in UNIX tar format. It is also available on a 3.5 inch diskette in UNIX tar format. KNET was developed in 1991 and is a copyrighted work with all copyright vested in NASA. UNIX is a registered trademark of AT&T Bell Laboratories. Sun and SunOS are trademarks of Sun Microsystems, Inc. DECstation, VAX, VMS, and ULTRIX are trademarks of Digital Equipment Corporation.

Reliability considerations of a fuel cell backup power system for telecom applications

NASA Astrophysics Data System (ADS)

Serincan, Mustafa Fazil

2016-03-01

A commercial fuel cell backup power unit is tested in real life operating conditions at a base station of a Turkish telecom operator. The fuel cell system responds to 256 of 260 electric power outages successfully, providing the required power to the base station. Reliability of the fuel cell backup power unit is found to be 98.5% at the system level. On the other hand, a qualitative reliability analysis at the component level is carried out. Implications of the power management algorithm on reliability is discussed. Moreover, integration of the backup power unit to the base station ecosystem is reviewed in the context of reliability. Impact of inverter design on the stability of the output power is outlined. Significant current harmonics are encountered when a generic inverter is used. However, ripples are attenuated significantly when a custom design inverter is used. Further, fault conditions are considered for real world case studies such as running out of hydrogen, a malfunction in the system, or an unprecedented operating scheme. Some design guidelines are suggested for hybridization of the backup power unit for an uninterrupted operation.

A demonstrative model of a lunar base simulation on a personal computer

NASA Technical Reports Server (NTRS)

1985-01-01

The initial demonstration model of a lunar base simulation is described. This initial model was developed on the personal computer level to demonstrate feasibility and technique before proceeding to a larger computer-based model. Lotus Symphony Version 1.1 software was used to base the demonstration model on an personal computer with an MS-DOS operating system. The personal computer-based model determined the applicability of lunar base modeling techniques developed at an LSPI/NASA workshop. In addition, the personnal computer-based demonstration model defined a modeling structure that could be employed on a larger, more comprehensive VAX-based lunar base simulation. Refinement of this personal computer model and the development of a VAX-based model is planned in the near future.

Design and evaluation of FDDI fiber optics networkfor Ethernets, VAX's and Ingraph work stations

NASA Technical Reports Server (NTRS)

Wernicki, M. Chris

1992-01-01

The purpose of this project is to design and evaluate the FDDI Fiber Optics Network for Ethernets, VAX's, and Ingraph work stations. From the KSC Headquarters communication requirement, it would be necessary to develop the FDDI network based on IEEE Standards outlined in the ANSI X3T9.5, Standard 802.3 and 802.5 topology - direct link via intermediate concentrator and bridge/router access. This analysis should examine the major factors that influence the operating conditions of the Headquarters Fiber plant. These factors would include, but are not limited to the interconnecting devices such as repeaters, bridges, routers and many other relevant or significant FDDI characteristics. This analysis is needed to gain a better understanding of overall FDDI performance.

Microvax-based data management and reduction system for the regional planetary image facilities

NASA Technical Reports Server (NTRS)

Arvidson, R.; Guinness, E.; Slavney, S.; Weiss, B.

1987-01-01

Presented is a progress report for the Regional Planetary Image Facilities (RPIF) prototype image data management and reduction system being jointly implemented by Washington University and the USGS, Flagstaff. The system will consist of a MicroVAX with a high capacity (approx 300 megabyte) disk drive, a compact disk player, an image display buffer, a videodisk player, USGS image processing software, and SYSTEM 1032 - a commercial relational database management package. The USGS, Flagstaff, will transfer their image processing software including radiometric and geometric calibration routines, to the MicroVAX environment. Washington University will have primary responsibility for developing the database management aspects of the system and for integrating the various aspects into a working system.

Controller and interface module for the High-Speed Data Acquisition System correlator/accumulator

NASA Technical Reports Server (NTRS)

Brokl, S. S.

1985-01-01

One complex channel of the High-Speed Data Acquisition System (a subsystem used in the Goldstone solar system radar), consisting of two correlator modules and one accumulator module, is operated by the controller and interface module interfaces are provided to the VAX UNIBUS for computer control, monitor, and test of the controller and correlator/accumulator. The correlator and accumulator modules controlled by this module are the key digital signal processing elements of the Goldstone High-Speed Data Acquisition System. This fully programmable unit provides for a wide variety of correlation and filtering functions operating on a three megaword/second data flow. Data flow is to the VAX by way of the I/O port of a FPS 5210 array processor.

Ada Compiler Validation Summary Report: Certificate Number 891201S1. 10214 U.S. Navy Ada/M, Version 2.0 (/OPTIMIZE Option) VAX 8550 and VAX 11/785 Hosts AN/UYK-44 Target

DTIC Science & Technology

1989-12-01

s -M-COM ST-1815A, Ada Joint Program Office 17.gbJftYCLSSF~ATW4 Is. SECURITY CLASSFAT04 OAS. TRUmVACAT M. LUITAf WCOF ABSTRACT Xi LLASSIFIED I CM ...Department of Defense Dist Specla Washington DC 20301 AVF Control Number: NIST89USN5556_1. 10 DATE VSR CPIEM BEFORE ON-SITE: 08-11-89 DATE VSR C34PLETED AFTER...ON-SITE: 12-04-89 DATE VSR MODIFIED PER AVO C31ME : 12-29-89 DATE VSR MODIFIED PER AVO CMtEN: 04-27-90 Ada O4PIIER VALIDATION SUM4M REPORT

Ada Compiler Validation Summary Report: Certificate Number 891201S1. 10213 U.S. Navy Ada/M Version 2.0 (/NO Optimize Option) VAX 8550 and VAX 11/785 Hosts and AN/UYK-44 Target

DTIC Science & Technology

1989-12-01

T~IC F LE COK _"_ "NTATION PAGE I r070O18- AD-A223 693 M w-__wow_=ORT DATE ILREPORT TYP ND DATES CM RID I Dec 89 to I Dec 90 Final 4.1LE frMlTWLE...target), 891201.10213 LAVUTORS) National Institute of Standards and Technology Gaithersburg, MD USA 7 . PEWOOMWOPAA AT HW M S) L PEVodM ORGANIZATION 7 ...DATE VSR CCLPIETED BEFORE CN-SITE: 08-11-89 DATE VSR CPEIED AFE ON-SITE: 12-04-89 DATE VSR MODIFIED PER AVO CCMKENTS: 12-29-89 DATE VSR MODIFIED PER AVO

A review of ISEAS design

NASA Technical Reports Server (NTRS)

Bykat, Alex

1993-01-01

The Space Station Freedom will offer facilities for experimentation and testing not available and not feasible or possible on earth. Due to a restricted space availability on board, the experimentation equipment and its organization will be frequently changing. This requires careful attention to electromagnetic compatibility between experimentation and other SSF equipment. To analyze the interactions between different equipment modules, a software system ISEAS is under development. Development of ISEAS was approached in two phases. In the 1st phase a PC version prototype of ISEAS was developed. In the 2nd phase, the PC prototype will be adapted to a VAX range of computers. The purpose of this paper is to review the design of the VAX version of ISEAS, and to recommend any suitable changes.

Efficient implementation of real-time programs under the VAX/VMS operating system

NASA Technical Reports Server (NTRS)

Johnson, S. C.

1985-01-01

Techniques for writing efficient real-time programs under the VAX/VMS oprating system are presented. Basic operations are presented for executing at real-time priority and for avoiding needlless processing delays. A highly efficient technique for accessing physical devices by mapping to the input/output space and accessing the device registrs directly is described. To illustrate the application of the technique, examples are included of different uses of the technique on three devices in the Langley Avionics Integration Research Lab (AIRLAB): the KW11-K dual programmable real-time clock, the Parallel Communications Link (PCL11-B) communication system, and the Datacom Synchronization Network. Timing data are included to demonstrate the performance improvements realized with these applications of the technique.

Onsite and Electric Backup Capabilities at Critical Infrastructure Facilities in the United States

DOE Office of Scientific and Technical Information (OSTI.GOV)

Phillips, Julia A.; Wallace, Kelly E.; Kudo, Terence Y.

2016-04-01

The following analysis, conducted by Argonne National Laboratory’s (Argonne’s) Risk and Infrastructure Science Center (RISC), details an analysis of electric power backup of national critical infrastructure as captured through the Department of Homeland Security’s (DHS’s) Enhanced Critical Infrastructure Program (ECIP) Initiative. Between January 1, 2011, and September 2014, 3,174 ECIP facility surveys have been conducted. This study focused first on backup capabilities by infrastructure type and then expanded to infrastructure type by census region.

Apollo 11 - Prime and Backup Crews - Geology Training - TX

NASA Image and Video Library

1969-03-03

S69-25199 (25 Feb. 1969) --- Two Apollo 11 astronauts study a rock specimen during a geological field trip to the Quitman Mountains area near the Fort Quitman ruins in far west Texas. On the left is James A. Lovell Jr., Apollo 11 backup crew commander; and on the right is Fred W. Haise Jr., backup crew lunar module pilot. Lovell holds a camera which was used in simulating taking pictures of actual lunar samples on the surface of the Moon.

Improved performance in NASTRAN (R)

NASA Technical Reports Server (NTRS)

Chan, Gordon C.

1989-01-01

Three areas of improvement in COSMIC/NASTRAN, 1989 release, were incorporated recently that make the analysis program run faster on large problems. Actual log files and actual timings on a few test samples that were run on IBM, CDC, VAX, and CRAY computers were compiled. The speed improvement is proportional to the problem size and number of continuation cards. Vectorizing certain operations in BANDIT, makes BANDIT run twice as fast in some large problems using structural elements with many node points. BANDIT is a built-in NASTRAN processor that optimizes the structural matrix bandwidth. The VAX matrix packing routine BLDPK was modified so that it is now packing a column of a matrix 3 to 9 times faster. The denser and bigger the matrix, the greater is the speed improvement. This improvement makes a host of routines and modules that involve matrix operation run significantly faster, and saves disc space for dense matrices. A UNIX version, converted from 1988 COSMIC/NASTRAN, was tested successfully on a Silicon Graphics computer using the UNIX V Operating System, with Berkeley 4.3 Extensions. The Utility Modules INPUTT5 and OUTPUT5 were expanded to handle table data, as well as matrices. Both INPUTT5 and OUTPUT5 are general input/output modules that read and write FORTRAN files with or without format. More user informative messages are echoed from PARAMR, PARAMD, and SCALAR modules to ensure proper data values and data types being handled. Two new Utility Modules, GINOFILE and DATABASE, were written for the 1989 release. Seven rigid elements are added to COSMIC/NASTRAN. They are: CRROD, CRBAR, CRTRPLT, CRBE1, CRBE2, CRBE3, and CRSPLINE.

Chitosan-plasmid nanoparticle formulations for IM and SC delivery of recombinant FGF-2 and PDGF-BB or generation of antibodies.

PubMed

Jean, M; Smaoui, F; Lavertu, M; Méthot, S; Bouhdoud, L; Buschmann, M D; Merzouki, A

2009-09-01

Growth factor therapy is an emerging treatment modality that enhances tissue vascularization, promotes healing and regeneration and can treat a variety of inflammatory diseases. Both recombinant human growth factor proteins and their gene therapy are in human clinical trials to heal chronic wounds. As platelet-derived growth factor-bb (PDGF-BB) and fibroblast growth factor-2 (FGF-2) are known to induce chemotaxis, proliferation, differentiation, and matrix synthesis, we investigated a non-viral means for gene delivery of these factors using the cationic polysaccharide chitosan. Chitosan is a polymer of glucosamine and N-acetyl-glucosamine, in which the percentage of the residues that are glucosamine is called the degree of deacetylation (DDA). The purpose of this study was to express PDGF-BB and FGF-2 genes in mice using chitosan-plasmid DNA nanoparticles for the controlled delivery of genetic material in a specific, efficient, and safe manner. PDGF-BB and FGF-2 genes were amplified from human tissues by RT-PCR. To increase the secretion of FGF-2, a recombinant 4sFGF-2 was constructed bearing eight amino-acid residues of the signal peptide of FGF-4. PCR products were inserted into the expression vector pVax1 to produce recombinant plasmids pVax1-4sFGF2 and pVax1-PDGF-BB, which were then injected into BALB/C mice in the format of polyelectrolyte nanocomplexes with specific chitosans of controlled DDA and molecular weight, including 92-10, 80-10, and 80-80 (DDA-number average molecular weight or M(n) in kDa). ELISA assays on mice sera showed that recombinant FGF-2 and PDGF-BB proteins were efficiently expressed and specific antibodies to these proteins could be identified in sera of injected mice, but with levels that were clearly dependent on the specific chitosan used. We found high DDA low molecular weight chitosans to be efficient protein expressors with minimal or no generation of neutralizing antibodies, while lowering DDA resulted in greater antibody levels and correspondingly lower levels of detected recombinant protein. Histological analyses corroborated these results by revealing greater inflammatory infiltrates in lower DDA chitosans, which produced higher antibody titers. We found, in general, a more efficient delivery of the plasmids by subcutaneous than by intramuscular injection. Specific chitosan carriers were identified to be either efficient non-toxic therapeutic protein delivery systems or vectors for DNA vaccines.

STS-55 German payload specialists and backups pose in front of SL-D2 at KSC

NASA Technical Reports Server (NTRS)

1992-01-01

STS-55 Columbia, Orbiter Vehicle (OV) 102, German payload specialists and backup (alternate) payload specialists pose in front of the Spacelab Deutsche 2 (SL-D2) science module at a Kennedy Space Center (KSC) processing facility. These four Germans have been assigned to support the STS-55/SL-D2 mission. Left to right are Payload Specialist 2 Hans Schlegel, backup Payload Specialist Dr. P. Gerhard Thiele (kneeling), Payload Specialist 1 Ulrich Walter, and backup Payload Specialist Renate Brummer. Walter and Schlegel are scheduled to fly aboard OV-102 for the mission while Brummer and Thiele will serve as alternates and fill supportive roles on the ground. Clearly visible on the SL-D2 module are the European Space Agency (ESA) insignia, the feedthrough plate, and the D2 insignia.

Enhanced networked server management with random remote backups

NASA Astrophysics Data System (ADS)

Kim, Song-Kyoo

2003-08-01

In this paper, the model is focused on available server management in network environments. The (remote) backup servers are hooked up by VPN (Virtual Private Network) and replace broken main severs immediately. A virtual private network (VPN) is a way to use a public network infrastructure and hooks up long-distance servers within a single network infrastructure. The servers can be represent as "machines" and then the system deals with main unreliable and random auxiliary spare (remote backup) machines. When the system performs a mandatory routine maintenance, auxiliary machines are being used for backups during idle periods. Unlike other existing models, the availability of auxiliary machines is changed for each activation in this enhanced model. Analytically tractable results are obtained by using several mathematical techniques and the results are demonstrated in the framework of optimized networked server allocation problems.

CASE/A - COMPUTER AIDED SYSTEM ENGINEERING AND ANALYSIS, ECLSS/ATCS SERIES

NASA Technical Reports Server (NTRS)

Bacskay, A.

1994-01-01

Design and analysis of Environmental Control and Life Support Systems (ECLSS) and Active Thermal Control Systems (ATCS) for spacecraft missions requires powerful software that is flexible and responsive to the demands of particular projects. CASE/A is an interactive trade study and analysis tool designed to increase productivity during all phases of systems engineering. The graphics-based command-driven package provides a user-friendly environment in which the engineer can analyze the performance and interface characteristics of an ECLS/ATC system. The package is useful during all phases of a spacecraft design program, from initial conceptual design trade studies to the actual flight, including pre-flight prediction and in-flight anomaly analysis. The CASE/A program consists of three fundamental parts: 1) the schematic management system, 2) the database management system, and 3) the simulation control and execution system. The schematic management system allows the user to graphically construct a system model by arranging icons representing system components and connecting the components with physical fluid streams. Version 4.1 contains 51 fully coded and documented default component routines. New components can be added by the user through the "blackbox" component option. The database management system supports the storage and manipulation of component data, output data, and solution control data through interactive edit screens. The simulation control and execution system initiates and controls the iterative solution process, displaying time status and any necessary diagnostic messages. In addition to these primary functions, the program provides three other important functional areas: 1) model output management, 2) system utility commands, and 3) user operations logic capacity. The model output management system provides tabular and graphical output capability. Complete fluid constituent mass fraction and properties data (mass flow, pressure, temperature, specific heat, density, and viscosity) is generated at user-selected output intervals and stored for reference. The Integrated Plot Utility (IPU) provides plotting capability for all data output. System utility commands are provided to enable the user to operate more efficiently in the CASE/A environment. The user is able to customize a simulation through optional operations FORTRAN logic. This user-developed code is compiled and linked with a CASE/A model and enables the user to control and timeline component operating parameters during various phases of the iterative solution process. CASE/A provides for transient tracking of the flow stream constituents and determination of their thermodynamic state throughout an ECLSS/ATCS simulation, performing heat transfer, chemical reaction, mass/energy balance, and system pressure drop analysis based on user-specified operating conditions. The program tracks each constituent through all combination and decomposition states while maintaining a mass and energy balance on the overall system. This allows rapid assessment of ECLSS designs, the impact of alternate technologies, and impacts due to changes in metabolic forcing functions, consumables usage, and system control considerations. CASE/A is written in FORTRAN 77 for the DEC VAX/VMS computer series, and requires 12Mb of disk storage and a minimum paging file quota of 20,000 pages. The program operates on the Tektronix 4014 graphics standard and VT100 text standard. The program requires a Tektronix 4014 or later graphics terminal, third party composite graphics/text terminal, or personal computer loaded with appropriate VT100/TEK 4014 emulator software. The use of composite terminals or personal computers with popular emulation software is recommended for enhanced CASE/A operations and general ease of use. The program is available on an unlabeled 9-track 6250 BPI DEC VAX BACKUP format magnetic tape. CASE/A development began in 1985 under contract to NASA/Marshall Space Flight Center. The latest version (4.1) was released in 1990. Tektronix and TEK 4014 are trademarks of Tektronix, Inc. VT100 is a trademark of Digital Equipment Corporation.

Evaluation of protective efficacy of three novel H3N2 canine influenza vaccines

PubMed Central

Li, Lutao; Li, Xiuzhen; Hu, Renjun; Jia, Kun; Sun, Lingshuang; Yuan, Ziguo; Li, Shoujun

2017-01-01

Canine influenza virus (CIV) has the potential risk to spread in different areas and dog types. Thus, there is a growing need to develop an effective vaccine to control CIV disease. Here, we developed three vaccine candidates: 1) a recombinant pVAX1 vector expressing H3N2 CIV hemagglutinin (pVAX1-HA); 2) a live attenuated canine adenovirus type 2 expressing H3N2 CIV hemagglutinin (rCAV2-HA); and 3) an inactivated H3N2 CIV (A/canine/Guangdong/01/2006 (H3N2)). Mice received an initial intramuscular immunization that followed two booster injections at 2 and 4 weeks post-vaccination (wpv). The splenic lymphocytes were collected to assess the immune responses at 6 wpv. The protective efficacy was evaluated by challenging H3N2 CIV after vaccination (at 6 wpv). Our results demonstrated that all three vaccine candidates elicited cytokine and antibody responses in mice. The rCAV2-HA vaccine and the inactivated vaccine generated efficient protective efficacy in mice, whereas limited protection was provided by the pVAX1-HA DNA vaccine. Therefore, both the rCAV2-HA live recombinant virus and the inactivated CIV could be used as potential novel vaccines against H3N2CIV. This study provides guidance for choosing the most appropriate vaccine for the prevention and control of CIV disease. PMID:29228675

VIRTUAL FRAME BUFFER INTERFACE

NASA Technical Reports Server (NTRS)

Wolfe, T. L.

1994-01-01

Large image processing systems use multiple frame buffers with differing architectures and vendor supplied user interfaces. This variety of architectures and interfaces creates software development, maintenance, and portability problems for application programs. The Virtual Frame Buffer Interface program makes all frame buffers appear as a generic frame buffer with a specified set of characteristics, allowing programmers to write code which will run unmodified on all supported hardware. The Virtual Frame Buffer Interface converts generic commands to actual device commands. The virtual frame buffer consists of a definition of capabilities and FORTRAN subroutines that are called by application programs. The virtual frame buffer routines may be treated as subroutines, logical functions, or integer functions by the application program. Routines are included that allocate and manage hardware resources such as frame buffers, monitors, video switches, trackballs, tablets and joysticks; access image memory planes; and perform alphanumeric font or text generation. The subroutines for the various "real" frame buffers are in separate VAX/VMS shared libraries allowing modification, correction or enhancement of the virtual interface without affecting application programs. The Virtual Frame Buffer Interface program was developed in FORTRAN 77 for a DEC VAX 11/780 or a DEC VAX 11/750 under VMS 4.X. It supports ADAGE IK3000, DEANZA IP8500, Low Resolution RAMTEK 9460, and High Resolution RAMTEK 9460 Frame Buffers. It has a central memory requirement of approximately 150K. This program was developed in 1985.

An optical disk archive for a data base management system

NASA Technical Reports Server (NTRS)

Thomas, Douglas T.

1985-01-01

An overview is given of a data base management system that can catalog and archive data at rates up to 50M bits/sec. Emphasis is on the laser disk system that is used for the archive. All key components in the system (3 Vax 11/780s, a SEL 32/2750, a high speed communication interface, and the optical disk) are interfaced to a 100M bits/sec 16-port fiber optic bus to achieve the high data rates. The basic data unit is an autonomous data packet. Each packet contains a primary and secondary header and can be up to a million bits in length. The data packets are recorded on the optical disk at the same time the packet headers are being used by the relational data base management software ORACLE to create a directory independent of the packet recording process. The user then interfaces to the VAX that contains the directory for a quick-look scan or retrieval of the packet(s). The total system functions are distributed between the VAX and the SEL. The optical disk unit records the data with an argon laser at 100M bits/sec from its buffer, which is interfaced to the fiber optic bus. The same laser is used in the read cycle by reducing the laser power. Additional information is given in the form of outlines, charts, and diagrams.

Inactivated yellow fever 17D vaccine: development and nonclinical safety, immunogenicity and protective activity.

PubMed

Monath, Thomas P; Lee, Cynthia K; Julander, Justin G; Brown, Alicja; Beasley, David W; Watts, Douglas M; Hayman, Edward; Guertin, Patrick; Makowiecki, Joseph; Crowell, Joseph; Levesque, Philip; Bowick, Gavin C; Morin, Merribeth; Fowler, Elizabeth; Trent, Dennis W

2010-05-14

In the last 10 years new concerns have arisen about safety of the live, attenuated yellow fever (YF) 17D vaccine, in particular viscerotropic adverse events, which have a case-fatality rate of 64%. A non-replicating cell culture-based vaccine would not cause these adverse events, and potentially could be used in persons with precautions or contraindications to use of the live vaccine, including age <9 months and >60 years, egg allergy, immune suppression, and pregnancy. We developed a whole virion vaccine from the 17D strain inactivated with beta-propiolactone, and adsorbed to aluminum hydroxide. The inactivated vaccine was highly immunogenic in mice, hamsters, and cynomolgus macaques. After a single dose in hamsters and macaques, neutralizing antibody titers were similar to those elicited by the live 17D vaccine (YF-VAX, Sanofi Pasteur). After two doses of inactivated vaccine, neutralizing antibody titers in hamsters were significantly higher than after a single dose of YF-VAX [geometric mean titer (GMT) 20,480 vs. 1940, respectively (P<0.001, ANOVA)]. Hamsters given a single dose or two doses of inactivated vaccine or a single dose of YF-VAX were fully protected against hepatitis, viremia, weight loss and death after challenge with YF virus (Jimenez strain). A clinical trial of the inactivated vaccine (XRX-001) has been initiated. Copyright 2010 Elsevier Ltd. All rights reserved.

Evaluation of protective efficacy of three novel H3N2 canine influenza vaccines.

PubMed

Tu, Liqing; Zhou, Pei; Li, Lutao; Li, Xiuzhen; Hu, Renjun; Jia, Kun; Sun, Lingshuang; Yuan, Ziguo; Li, Shoujun

2017-11-17

Canine influenza virus (CIV) has the potential risk to spread in different areas and dog types. Thus, there is a growing need to develop an effective vaccine to control CIV disease. Here, we developed three vaccine candidates: 1) a recombinant pVAX1 vector expressing H3N2 CIV hemagglutinin (pVAX1-HA); 2) a live attenuated canine adenovirus type 2 expressing H3N2 CIV hemagglutinin (rCAV2-HA); and 3) an inactivated H3N2 CIV (A/canine/Guangdong/01/2006 (H3N2)). Mice received an initial intramuscular immunization that followed two booster injections at 2 and 4 weeks post-vaccination (wpv). The splenic lymphocytes were collected to assess the immune responses at 6 wpv. The protective efficacy was evaluated by challenging H3N2 CIV after vaccination (at 6 wpv). Our results demonstrated that all three vaccine candidates elicited cytokine and antibody responses in mice. The rCAV2-HA vaccine and the inactivated vaccine generated efficient protective efficacy in mice, whereas limited protection was provided by the pVAX1-HA DNA vaccine. Therefore, both the rCAV2-HA live recombinant virus and the inactivated CIV could be used as potential novel vaccines against H3N2CIV. This study provides guidance for choosing the most appropriate vaccine for the prevention and control of CIV disease.

Gene Gun Bombardment with DNA-Coated Golden Particles Enhanced the Protective Effect of a DNA Vaccine Based on Thioredoxin Glutathione Reductase of Schistosoma japonicum

PubMed Central

Cao, Yan; Zhao, Bin; Han, Yanhui; Zhang, Juan; Li, Xuezhen; Qiu, Chunhui; Wu, Xiujuan; Hong, Yang; Ai, Dezhou; Lin, Jiaojiao; Fu, Zhiqiang

2013-01-01

Schistosomiasis, caused by infection with Schistosoma species, remains an important parasitic zoonosis. Thioredoxin glutathione reductase of Schistosoma japonicum (SjTGR) plays an important role in the development of the parasite and for its survival. Here we present a recombinant plasmid DNA vaccine, pVAX1/SjTGR, to estimate its protection against S. japonicum in BALB/c mice. The DNA vaccine administrated by particle bombardment induced higher protection than by intramuscular injection. All animals vaccinated with pVAX1/SjTGR developed significant specific anti-SjTGR antibodies than control groups. Moreover, animals immunized by gene gun exhibited a splenocyte proliferative response, with an increase in IFN-γ and IL-4. The recombinant plasmid administrated by gene gun achieved a medium protective efficacy of 27.83–38.83% (P < 0.01) of worm reduction and 40.38–44.51% (P < 0.01) of liver egg count reduction. It suggests that different modes of administering a DNA vaccine can influence the protective efficacy induced by the vaccine. Interestingly, from the enzymatic activity results, we found that worms obtained from pVAX1/SjTGR-vaccinated animals expressed lower enzymatic activity than the control group and the antibodies weakened the enzymatic activity of SjTGR in vitro, too. It implies that the high-level antibodies may contribute to the protective effects. PMID:23509820

STS-55 German payload specialists (and backups) in LESs during JSC training

NASA Technical Reports Server (NTRS)

1992-01-01

STS-55 Columbia, Orbiter Vehicle (OV) 102, German payload specialists and backup (alternate) payload specialists, wearing launch and entry suits (LESs), pose for group portrait outside mockup side hatch in JSC's Mockup and Integration Laboratory (MAIL) Bldg 9NE. These payload specialists will support the STS-55 Spacelab Deutsche 2 (SL-D2) mission. It is the second dedicated German (Deutsche) Spacelab flight. Left to right are backup Payload Specialists Renate Brummer and Dr. P. Gerhard Thiele, Payload Specialist 1 Ulrich Walter, and Payload Specialist 2 Hans Schlegel.

Bearing system

DOEpatents

Kapich, Davorin D.

1987-01-01

A bearing system includes backup bearings for supporting a rotating shaft upon failure of primary bearings. In the preferred embodiment, the backup bearings are rolling element bearings having their rolling elements disposed out of contact with their associated respective inner races during normal functioning of the primary bearings. Displacement detection sensors are provided for detecting displacement of the shaft upon failure of the primary bearings. Upon detection of the failure of the primary bearings, the rolling elements and inner races of the backup bearings are brought into mutual contact by axial displacement of the shaft.

STS-47 Payload Specialist Mohri and Japanese backups pose in SLJ module at KSC

NASA Technical Reports Server (NTRS)

1992-01-01

STS-47 payload specialists representing Japan's National Space Development Agency (NASDA) examine the interior of the Spacelab Japan (SLJ) laboratory module recently installed in Endeavour's, Orbiter Vehicle (OV) 105's, payload bay (PLB). Left to right are Payload Specialist Mamoru Mohri, backup Payload Specialist Chiaki Naito-Mukai, and backup Payload Specialist Takao Doi. The crewmembers visited OV-105, currently undergoing preflight processing in a high bay area of Kennedy Space Center's (KSC's) Orbiter Processing Facility (OPF). View provided by KSC with alternate KSC number KSC-92PC-1649.

View of backup payload specialist Robert Thirsk during Zero-G training

NASA Image and Video Library

1984-07-16

S84-37532 (18 July 1984) --? Robert B. Thirsk, backup payload specialist for 41-G appears to be shaking hands with an unoccupied extravehicular mobility unit (EMU) during a familiarization flight aboard NASA?s KC-135 aircraft. Thirsk, representing Canada?s National Research Council (NRC), serves as backup to Marc Garneau on the seven-member crew for Challenger?s October 1984 flight. This aircraft is used extensively for training and exposing Shuttle crewmembers to weightlessness as well as for evaluation of equipment and experiments scheduled for future flights.

PFP Emergency Lighting Study

DOE Office of Scientific and Technical Information (OSTI.GOV)

BUSCH, M.S.

2000-02-02

NFPA 101, section 5-9 mandates that, where required by building classification, all designated emergency egress routes be provided with adequate emergency lighting in the event of a normal lighting outage. Emergency lighting is to be arranged so that egress routes are illuminated to an average of 1.0 footcandle with a minimum at any point of 0.1 footcandle, as measured at floor level. These levels are permitted to drop to 60% of their original value over the required 90 minute emergency lighting duration after a power outage. The Plutonium Finishing Plant (PFP) has two designations for battery powered egress lights ''Emergencymore » Lights'' are those battery powered lights required by NFPA 101 to provide lighting along officially designated egress routes in those buildings meeting the correct occupancy requirements. Emergency Lights are maintained on a monthly basis by procedure ZSR-12N-001. ''Backup Lights'' are battery powered lights not required by NFPA, but installed in areas where additional light may be needed. The Backup Light locations were identified by PFP Safety and Engineering based on several factors. (1) General occupancy and type of work in the area. Areas occupied briefly during a shiftly surveillance do not require backup lighting while a room occupied fairly frequently or for significant lengths of time will need one or two Backup lights to provide general illumination of the egress points. (2) Complexity of the egress routes. Office spaces with a standard hallway/room configuration will not require Backup Lights while a large room with several subdivisions or irregularly placed rooms, doors, and equipment will require Backup Lights to make egress safer. (3) Reasonable balance between the safety benefits of additional lighting and the man-hours/exposure required for periodic light maintenance. In some plant areas such as building 236-Z, the additional maintenance time and risk of contamination do not warrant having Backup Lights installed in all rooms. Sufficient light for egress is provided by existing lights located in the hallways.« less

PAD_AUDIT -- PAD Auditing Package

NASA Astrophysics Data System (ADS)

Clayton, C. A.

The PAD (Packet Assembler Disassembler) utility is the part of the VAX/VMS Coloured Book Software (CBS) which allows a user to log onto remote computers from a local VAX. Unfortunately, logging into a computer via either the Packet SwitchStream (PSS) or the International Packet SwitchStream (IPSS) costs real money. Some users either do not appreciate this or do not care and have been known to clock up rather large quarterly bills. This software package allows a system manager to determine who has used PAD to call where and (most importantly) how much it has cost. The system manager can then take appropriate action - either charging the individuals, warning them to use the facility with more care or even denying access to a greedy user to one or more sites.

Ada Compiler Validation Summary Report: Certificate Number: 891201S1. 10215 U.S. Navy Ada/M, Version 2.0 (/No Optimize Option) VAX 8550 and VAX 11/785 Host and AN/AYK-14 Target

DTIC Science & Technology

1990-01-12

NIST89USN555 7 1.10 DATE VSR CPIIED BEFORE ON-SITE: 08-11-89 DATE VSR COMPI=E AFTER ON-SITE: 12-04-89 DATE VSR MODIFIED PER AVO COMMENS: 12-29-89 DATE...AD-A223 579I I Final 12 Jan 89 to 12 Jan 90 4WPUASS1TTL Ada Compler Validation Summary Report: U.S. Navy.~ Gaithersburg, E1D A USA 7 . PEXNX&M...0Rl3Wfl4 NUADACAMSO) R. A flff om4oN National Institute of Standards and Technology = & National Computer Systew± !.boratory N/S T U W6�- 7 /0 Bldg. 255, Em

Optimization of preparation of NDV F Gene encapsulated in N-2-HACC-CMC nanoparticles

NASA Astrophysics Data System (ADS)

Li, S. S.; Zhang, Y.; Zhao, K.; Wang, X. H.

2018-01-01

In this study, the biodegradable materials N-2-hydroxypropyl trimethyl ammonium chloride chitosan (N-2-HACC) and N, O-carboxymethyl chitosan (CMC) are used as delivery carrier for the pVAX I -F(o)-C3d6. The optimal preparation condition is as follows: concentration of N-2-HACC is 1.0 mg/ml, concentration of CMC is 0.85 mg/ml, concentration of pVAX I -F(o)-C3d6 is 100 μg ml. The results show that the prepared N-2-HACC-CMC/pFDNA NPs have regular round shape, smooth surface and good dispersion, the particle size is 310 nm, Zeta potential is 50 mV, the entrapment efficiency is 92 %, the loading capacity is 51 % (n=3).

Backup Warning Signals: Driver Perception and Response

DOT National Transportation Integrated Search

1996-08-01

This report describes the findings of three experiments that concern driver reaction to acoustic signals that might be used for backup warning devices. Intelligent warning devices are under development that will use vehicle-based sensors to warn back...

Official portrait of STS-65 backup Payload Specialist Jean-Jacques Favier

NASA Image and Video Library

1993-09-30

Official portrait of STS-65 International Microgravity Laboratory 2 (IML-2) backup Payload Specialist Jean-Jacques Favier. Favier is a member of the Centre National D'Etudes Spatiales (CNES), the French space agency.

Improvement on Main/backup Controller Switching Device of the Nozzle Throat Area Control System for a Turbofan Aero Engine

NASA Astrophysics Data System (ADS)

Li, Jie; Duan, Minghu; Yan, Maode; Li, Gang; Li, Xiaohui

2014-06-01

A full authority digital electronic controller (FADEC) equipped with a full authority hydro-mechanical backup controller (FAHMBC) is adopted as the nozzle throat area control system (NTACS) of a turbofan aero engine. In order to ensure the switching reliability of the main/backup controller, the nozzle throat area control switching valve was improved from three-way convex desktop slide valve to six-way convex desktop slide valve. Simulation results show that, if malfunctions of FAEDC occur and abnormal signals are outputted from FADEC, NTACS will be seriously influenced by the main/backup controller switching in several working states, while NTACS will not be influenced by using the improved nozzle throat area control switching valve, thus the controller switching process will become safer and smoother and the working reliability of this turbofan aero engine is improved by the controller switching device improvement.

MMR Vaccine (Measles, Mumps, and Rubella)

MedlinePlus

Attenuvax® Measles Vaccine ... R-Vax® II (as a combination product containing Measles Vaccine, Rubella Vaccine) ... M-R® II (as a combination product containing Measles Vaccine, Mumps Vaccine, Rubella Vaccine)

Methods to assess carbonaceous aerosol sampling artifacts for IMPROVE and other long-term networks.

PubMed

Watson, John G; Chow, Judith C; Chen, L W Antony; Frank, Neil H

2009-08-01

Volatile organic compounds (VOCs) and semi-volatile organic compounds (SVOCs) adsorb to quartz fiber filters during fine and coarse particulate matter (PM2.5 and PM10, respectively) sampling for thermal/optical carbon analysis that measures organic carbon (OC) and elemental carbon (EC). Particulate SVOCs can evaporate after collection, with a small portion adsorbed within the filter. Adsorbed organic gases are measured as particulate OC, so passive field blanks, backup filters, prefilter organic denuders, and regression methods have been applied to compensate for positive OC artifacts in several long-term chemical speciation networks. Average backup filter OC levels from the Interagency Monitoring of Protected Visual Environments (IMPROVE) network were approximately 19% higher than field blank values. This difference is within the standard deviation of the average and likely results from low SVOC concentrations in the rural to remote environments of most IMPROVE sites. Backup filters from an urban (Fort Meade, MD) site showed twice the OC levels of field blanks. Sectioning backup filters from top to bottom showed nonuniform OC densities within the filter, contrary to the assumption that VOCs and SVOCs on a backup filter equal those on the front filter. This nonuniformity may be partially explained by evaporation and readsorption of vapors in different parts of the front and backup quartz fiber filter owing to temperature, relative humidity, and ambient concentration changes throughout a 24-hr sample duration. OC-PM2.5 regression analysis and organic denuder approaches demonstrate negative sampling artifact from both Teflon membrane and quartz fiber filters.

Optimization of robustness of interdependent network controllability by redundant design

PubMed Central

2018-01-01

Controllability of complex networks has been a hot topic in recent years. Real networks regarded as interdependent networks are always coupled together by multiple networks. The cascading process of interdependent networks including interdependent failure and overload failure will destroy the robustness of controllability for the whole network. Therefore, the optimization of the robustness of interdependent network controllability is of great importance in the research area of complex networks. In this paper, based on the model of interdependent networks constructed first, we determine the cascading process under different proportions of node attacks. Then, the structural controllability of interdependent networks is measured by the minimum driver nodes. Furthermore, we propose a parameter which can be obtained by the structure and minimum driver set of interdependent networks under different proportions of node attacks and analyze the robustness for interdependent network controllability. Finally, we optimize the robustness of interdependent network controllability by redundant design including node backup and redundancy edge backup and improve the redundant design by proposing different strategies according to their cost. Comparative strategies of redundant design are conducted to find the best strategy. Results shows that node backup and redundancy edge backup can indeed decrease those nodes suffering from failure and improve the robustness of controllability. Considering the cost of redundant design, we should choose BBS (betweenness-based strategy) or DBS (degree based strategy) for node backup and HDF(high degree first) for redundancy edge backup. Above all, our proposed strategies are feasible and effective at improving the robustness of interdependent network controllability. PMID:29438426

LAMDA programmer's manual

DOE Office of Scientific and Technical Information (OSTI.GOV)

Hughes, T.P.; Clark, R.M.; Mostrom, M.A.

This report discusses the following topics on the LAMDA program: General maintenance; CTSS FCL script; DOS batch files; Macintosh MPW scripts; UNICOS FCL script; VAX/MS command file; LINC calling tree; and LAMDA calling tree.

Design, Construction and Cloning of Truncated ORF2 and tPAsp-PADRE-Truncated ORF2 Gene Cassette From Hepatitis E Virus in the pVAX1 Expression Vector

PubMed Central

Farshadpour, Fatemeh; Makvandi, Manoochehr; Taherkhani, Reza

2015-01-01

Background: Hepatitis E Virus (HEV) is the causative agent of enterically transmitted acute hepatitis and has high mortality rate of up to 30% among pregnant women. Therefore, development of a novel vaccine is a desirable goal. Objectives: The aim of this study was to construct tPAsp-PADRE-truncated open reading frame 2 (ORF2) and truncated ORF2 DNA plasmid, which can assist future studies with the preparation of an effective vaccine against Hepatitis E Virus. Materials and Methods: A synthetic codon-optimized gene cassette encoding tPAsp-PADRE-truncated ORF2 protein was designed, constructed and analyzed by some bioinformatics software. Furthermore, a codon-optimized truncated ORF2 gene was amplified by the polymerase chain reaction (PCR), with a specific primer from the previous construct. The constructs were sub-cloned in the pVAX1 expression vector and finally expressed in eukaryotic cells. Results: Sequence analysis and bioinformatics studies of the codon-optimized gene cassette revealed that codon adaptation index (CAI), GC content, and frequency of optimal codon usage (Fop) value were improved, and performance of the secretory signal was confirmed. Cloning and sub-cloning of the tPAsp-PADRE-truncated ORF2 gene cassette and truncated ORF2 gene were confirmed by colony PCR, restriction enzymes digestion and DNA sequencing of the recombinant plasmids pVAX-tPAsp-PADRE-truncated ORF2 (aa 112-660) and pVAX-truncated ORF2 (aa 112-660). The expression of truncated ORF2 protein in eukaryotic cells was approved by an Immunofluorescence assay (IFA) and the reverse transcriptase polymerase chain reaction (RT-PCR) method. Conclusions: The results of this study demonstrated that the tPAsp-PADRE-truncated ORF2 gene cassette and the truncated ORF2 gene in recombinant plasmids are successfully expressed in eukaryotic cells. The immunogenicity of the two recombinant plasmids with different formulations will be evaluated as a novel DNA vaccine in future investigations. PMID:26865938

Bacteriological cure rate and changes in milk composition in mastitis vaccinated ewes affected with subclinical mastitis.

PubMed

Alekish, Myassar O; Ismail, Z Bani; Hammouri, H M; Daradka, M H; Taha, S Al; Olymat, I

2018-02-01

The aim of this study was to investigate the effects of using a commercially-available polyvalent mastitis vaccine on the bacteriological cure rate of existing subclinical mastitis in Awassi sheep. A total of 164 lactating ewes were divided into two main groups according to udder health and milk somatic cell count (SCC): Group 1=normal (N; n=80) and Group 2=subclinical mastitis (SC; n=84). Each group was then subdivided randomly into two treatment groups: N vaccinated (N vax ; n=38), N non-vaccinated (N nvax ; n=42), SC vaccinated (SC vax ; n=42), and SC non-vaccinated (SC nvax ; n=42). The vaccine was administered as per manufacturer's recommendations. Milk samples were collected aseptically from all ewes before vaccine administration (T0) and again on days 28 (T2) and 42 (T3) of the experiment. In the SC group, the bacteriological cure rates in vaccinated and non-vaccinated ewes were 76% and 69%, respectively. In N group, the new intramammary infection rates in vaccinated and non-vaccinated ewes were 48% and 50%, respectively. Vaccination of normal ewes resulted in a significant (p<0.05) reduction in bacterial growth rate both at day 28 and day 42 of the study. The prevalence of new intramammary infection rate in N vax ewes on days 28 and 42 was 19% and 20%, respectively. The prevalence of new intramammary infection rate in N nvax group on days 28 and 42 was 33% and 30%, respectively. In SC vax group, the bacterial growth rate on days 28 and 42 was 44% and 35%, respectively. In SC nvax group, the bacterial growth rate on days 28 and 42 was 27% and 32%, respectively. There was no statistically significant effect of vaccination on any of the studied milk composition parameters. This is a preliminary study that indicated a possible protective effect of vaccination against mastitis in sheep. Further, case-controlled studies are indicated to estimate the level of immunity this vaccine provides to vaccinated sheep.

Immunization with herpes simplex virus 2 (HSV-2) genes plus inactivated HSV-2 is highly protective against acute and recurrent HSV-2 disease.

PubMed

Morello, Christopher S; Levinson, Michael S; Kraynyak, Kimberly A; Spector, Deborah H

2011-04-01

To date, no vaccine that is safe and effective against herpes simplex virus 2 (HSV-2) disease has been licensed. In this study, we evaluated a DNA prime-formalin-inactivated-HSV-2 (FI-HSV2) boost vaccine approach in the guinea pig model of acute and recurrent HSV-2 genital disease. Five groups of guinea pigs were immunized and intravaginally challenged with HSV-2. Two groups were primed with plasmid DNAs encoding the secreted form of glycoprotein D2 (gD2t) together with two genes required for viral replication, either the helicase (UL5) and DNA polymerase (UL30) genes or the single-stranded DNA binding protein (UL29) and primase (UL52) genes. Both DNA-primed groups were boosted with FI-HSV2 formulated with monophosphoryl lipid A (MPL) and alum adjuvants. Two additional groups were primed with the empty backbone plasmid DNA (pVAX). These two groups were boosted with MPL and alum (MPL-alum) together with either formalin-inactivated mock HSV-2 (FI-Mock) or with FI-HSV2. The final group was immunized with gD2t protein in MPL-alum. After challenge, 0/9 animals in the group primed with UL5, UL30, and gD2t DNAs and all 10 animals in the mock-immunized control group (pVAX-FI-Mock) developed primary lesions. All mock controls developed recurrent lesions through day 100 postchallenge. Only 1 guinea pig in the group primed with pVAX DNA and boosted with FI-HSV2 (pVAX-FI-HSV2 group) and 2 guinea pigs in the group primed with UL5, UL30, and gD2t DNAs and boosted with FI-HSV2 (UL5, UL30, gD2t DNA-FI-HSV2 group) developed recurrent lesions. Strikingly, the UL5, UL30, gD2t DNA-FI-HSV2 group showed a 97% reduction in recurrent lesion days compared with the mock controls, had the highest reduction in days with recurrent disease, and contained the lowest mean HSV-2 DNA load in the dorsal root ganglia.

Expedition 9 Preflight Activities

NASA Image and Video Library

2004-04-13

NASA Expedition 9 backup Commander Leroy Chiao, left and backup European Space Agency astronaut Gerhard Thiele of Germany sign books, envelops and mementoes in the space museum located at the Baikonur Cosmodrome, Wednesday, April, 14, 2004, in Baikonur, Kazakhstan. Photo Credit: (NASA/Bill Ingalls)

STS-47 Japanese Payload Specialist Mohri and backups during Homestead training

NASA Technical Reports Server (NTRS)

1990-01-01

STS-47 Endeavour, Orbiter Vehicle (OV) 105, Japanese Payload Specialist Mamoru Mohri (far left), backup Payload Specialist Takao Doi (center), and backup Payload Specialist Chiaki Mukai (right) participate in water survival training at Homestead Air Force Base, Florida. Dockside, Mohri and Mukai wash the salt water from their personalized helmets after a water exercise. The three-day course was attended by the STS-47 prime and alternate payload specialists shortly after they were announced for the scheduled summer of 1992 Spacelab Japan (SLJ) mission. Mohri, Doi, and Mukai all represent the National Space Development Agency of Japan (NASDA).

Do familiar teammates request and accept more backup? Transactive memory in air traffic control.

PubMed

Smith-Jentsch, Kimberly A; Kraiger, Kurt; Cannon-Bowers, Janis A; Salas, Eduardo

2009-04-01

The present study investigated factors that explain when and why different groups of teammates are more likely to request and accept backup from one another when needed in an environment characterized by extreme time pressure and severe consequences of error: commercial air traffic control (ATC). Transactive memory theory states that teammates develop consensus regarding the distribution of their relative expertise as well as confidence in that expertise over time and that this facilitates coordination processes. The present study investigated whether this theory could help to explain between-team differences in requesting and accepting backup when needed. The present study used cross-sectional data collected from 51 commercial ATC teams. Hypotheses were tested using multiple regression analysis. Teammates with greater experience working together requested and accepted backup from one another more than those with lesser experience working together. Teammate knowledge consensus and perceived team efficacy appear to have mediated this relationship. Transactive memory theory extends to high-stress environments in which members' expertise is highly overlapping. Teammates' shared mental models about one another increase the likelihood that they will request and accept backup. Teammate familiarity should be considered when choosing among potential replacement team members. Training strategies that accelerate the development of teammate knowledge consensus and team efficacy are warranted.

Comparison of circular orbit and Fourier power series ephemeris representations for backup use by the upper atmosphere research satellite onboard computer

NASA Technical Reports Server (NTRS)

Kast, J. R.

1988-01-01

The Upper Atmosphere Research Satellite (UARS) is a three-axis stabilized Earth-pointing spacecraft in a low-Earth orbit. The UARS onboard computer (OBC) uses a Fourier Power Series (FPS) ephemeris representation that includes 42 position and 42 velocity coefficients per axis, with position residuals at 10-minute intervals. New coefficients and 32 hours of residuals are uploaded daily. This study evaluated two backup methods that permit the OBC to compute an approximate spacecraft ephemeris in the event that new ephemeris data cannot be uplinked for several days: (1) extending the use of the FPS coefficients previously uplinked, and (2) switching to a simple circular orbit approximation designed and tested (but not implemented) for LANDSAT-D. The FPS method provides greater accuracy during the backup period and does not require additional ground operational procedures for generating and uplinking an additional ephemeris table. The tradeoff is that the high accuracy of the FPS will be degraded slightly by adopting the longer fit period necessary to obtain backup accuracy for an extended period of time. The results for UARS show that extended use of the FPS is superior to the circular orbit approximation for short-term ephemeris backup.

Near-term high potential counties for SWECS

NASA Astrophysics Data System (ADS)

Osborn, W. C.; Downey, W. T.

1981-02-01

Up-to-date market information to manufacturers of small wind energy conversion system (SWECS) to assist them in developing marketing strategies for their products are provided. The data are arranged in a format that permits rapid identification of a particular location or market segment for further investigation. Extensive backup information by state and county in state SWECS Market reports are appended. It is suggested that the information are useful to SWECS manufacturers for planning new marketing and advertising activities. Background information essential to market studies is synthesized and an initial framework to start such a study is provided.

Sealing a Loosely Fitting Valve Assembly

NASA Technical Reports Server (NTRS)

Goff, L.; Tellier, G.

1986-01-01

Double-ring seal avoids expense of remachining or redesigning valve parts. Mating fittings on valve sealed by pair of rings - one O-ring and backup ring. Backup ring fills relatively large gap between parts. Prevents softer O-ring from being pushed into and through gap.

Close up of backup exciter showing induction motor at left ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

Close up of backup exciter showing induction motor at left and direct current generator at right. View to west - Mystic Lake Hydroelectric Facility, Powerhouse, Along West Rosebud Creek, 1 3/4 miles northeast of Mystic Lake Dam, Fishtail, Stillwater County, MT

Improvements to the fastex flutter analysis computer code

NASA Technical Reports Server (NTRS)

Taylor, Ronald F.

1987-01-01

Modifications to the FASTEX flutter analysis computer code (UDFASTEX) are described. The objectives were to increase the problem size capacity of FASTEX, reduce run times by modification of the modal interpolation procedure, and to add new user features. All modifications to the program are operable on the VAX 11/700 series computers under the VAX operating system. Interfaces were provided to aid in the inclusion of alternate aerodynamic and flutter eigenvalue calculations. Plots can be made of the flutter velocity, display and frequency data. A preliminary capability was also developed to plot contours of unsteady pressure amplitude and phase. The relevant equations of motion, modal interpolation procedures, and control system considerations are described and software developments are summarized. Additional information documenting input instructions, procedures, and details of the plate spline algorithm is found in the appendices.

Exercise-induced serum enzyme elevations confounding the evaluation of investigational drug toxicity. Report of two cases in a vaccine trial.

PubMed

Johnson, Casey; Monath, Thomas P; Kanesa-Thasan, Niranjan; Mathis, Danell; Miller, Chuck; Shapiro, Seth; Nichols, Richard; McCarthy, Karen; Deary, Alison; Bedford, Philip

2005-01-01

Two subjects developed marked elevations in creatine kinase and other serum enzymes associated with mild myalgia during a randomized, double-blind, controlled Phase 1 clinical trial of an investigational live, attenuated vaccine against West Nile virus (ChimeriVax-WN02). One subject had received ChimeriVax-WN02 while the other subject was enrolled in an active control group and received licensed yellow fever 17D vaccine (YF-VAX). Subsequently, the clinical trial was interrupted, and an investigation was begun to evaluate the enzyme abnormalities. As daily serum samples were collected for determination of quantitative viremia, it was possible to define the enzyme elevations with precision and to relate these elevations to physical activity of the subjects, symptoms, and virological and serological measurements. Evaluation of both subjects clearly showed that skeletal muscle injury, and not cardiac or hepatic dysfunction, was responsible for the biochemical abnormalities. This investigation also implicated strenuous exercise as the cause of the apparent muscle injury rather than the study vaccines. As a result of this experience, subjects engaged in future early-stage trials of these live, attenuated viral vaccines will be advised not to engage in contact sports or new or enhanced exercise regimens for which they are not trained or conditioned. The inclusion of placebo control arm (in lieu of or addition to an active vaccine control) will also be useful in differentiating causally related serum enzyme elevations.

Comparative Adjuvant Effects of Type II Heat-Labile Enterotoxins in Combination with Two Different Candidate Ricin Toxin Vaccine Antigens.

PubMed

Vance, David J; Greene, Christopher J; Rong, Yinghui; Mandell, Lorrie M; Connell, Terry D; Mantis, Nicholas J

2015-12-01

Type II heat-labile enterotoxins (HLTs) constitute a promising set of adjuvants that have been shown to enhance humoral and cellular immune responses when coadministered with an array of different proteins, including several pathogen-associated antigens. However, the adjuvant activities of the four best-studied HLTs, LT-IIa, LT-IIb, LT-IIb(T13I), and LT-IIc, have never been compared side by side. We therefore conducted immunization studies in which LT-IIa, LT-IIb, LT-IIb(T13I), and LT-IIc were coadministered by the intradermal route to mice with two clinically relevant protein subunit vaccine antigens derived from the enzymatic A subunit (RTA) of ricin toxin, RiVax and RVEc. The HLTs were tested with low and high doses of antigen and were assessed for their abilities to stimulate antigen-specific serum IgG titers, ricin toxin-neutralizing activity (TNA), and protective immunity. We found that all four HLTs tested were effective adjuvants when coadministered with RiVax or RVEc. LT-IIa was of particular interest because as little as 0.03 μg when coadministered with RiVax or RVEc proved effective at augmenting ricin toxin-specific serum antibody titers with nominal evidence of local inflammation. Collectively, these results justify the need for further studies into the mechanism(s) underlying LT-IIa adjuvant activity, with the long-term goal of evaluating LT-IIa's activity in humans. Copyright © 2015, American Society for Microbiology. All Rights Reserved.

Outcomes of nonemergent percutaneous coronary intervention with and without on-site surgical backup: a meta-analysis.

PubMed

Singh, Param Puneet; Singh, Mukesh; Bedi, Updesh Singh; Adigopula, Sasikanth; Singh, Sarabjeet; Kodumuri, Vamsi; Molnar, Janos; Ahmed, Aziz; Arora, Rohit; Khosla, Sandeep

2011-01-01

Despite major advances in percutaneous coronary intervention (PCI) techniques, the current guidelines recommend against elective PCI at hospitals without on-site cardiac surgery backup. Nonetheless, an increasing number of hospitals without on-site cardiac surgery in the United States have developed programs for elective PCI. Studies evaluating outcome in this setting have yielded mixed results, leaving the question unanswered. Hence, a meta-analysis comparing outcomes of nonemergent PCI in hospitals with and without on-site surgical backup was performed. A systematic review of literature identified four studies involving 6817 patients. Three clinical end points were extracted from each study and included in-hospital death, myocardial infarction, and the need for emergency coronary artery bypass grafting. The studies were homogenous for each outcome studied. Therefore, the combined relative risks (RRs) across all the studies and the 95% confidence intervals (CIs) were computed using the Mantel-Haenszel fixed-effect model. A two-sided alpha error less than 0.05 was considered to be statistically significant. Compared with facilities with on-site surgical backup, the risk of in-hospital death (RR, 2.7; CI, 0.6-12.9; P = 0.18), nonfatal myocardial infarction (RR, 1.3; CI, 0.7- 2.2; P = 0.29), and need of emergent coronary artery bypass grafting (RR, 0.46; CI, 0.06- 3.1; P = 0.43) was similar in those lacking on-site surgical backup. The present meta-analysis suggests that there is no difference in the outcome with regard to risk of nonfatal myocardial infarction, need for emergency coronary artery bypass grafting, and the risk of death in patients undergoing elective PCI in hospitals with and without on-site cardiac surgery backup.

47 CFR 12.2 - Backup power.

Code of Federal Regulations, 2011 CFR

2011-10-01

... exchange carriers, including incumbent local exchange carriers and competitive local exchange carriers..., must have an emergency backup power source (e.g., batteries, generators, fuel cells) for all assets... or local law; (2) Risk to safety of life or health; or (3) Private legal obligation or agreement. (c...

30 CFR 56.14132 - Horns and backup alarms.

Code of Federal Regulations, 2011 CFR

2011-07-01

....14132 Mineral Resources MINE SAFETY AND HEALTH ADMINISTRATION, DEPARTMENT OF LABOR METAL AND NONMETAL MINE SAFETY AND HEALTH SAFETY AND HEALTH STANDARDS-SURFACE METAL AND NONMETAL MINES Machinery and Equipment Safety Devices and Maintenance Requirements § 56.14132 Horns and backup alarms. (a) Manually...

30 CFR 56.14132 - Horns and backup alarms.

Code of Federal Regulations, 2010 CFR

2010-07-01

....14132 Mineral Resources MINE SAFETY AND HEALTH ADMINISTRATION, DEPARTMENT OF LABOR METAL AND NONMETAL MINE SAFETY AND HEALTH SAFETY AND HEALTH STANDARDS-SURFACE METAL AND NONMETAL MINES Machinery and Equipment Safety Devices and Maintenance Requirements § 56.14132 Horns and backup alarms. (a) Manually...

An audible automobile back-up pedestrian warning device--development and evaluation

DOT National Transportation Integrated Search

1976-11-01

The purpose of the study was to develop and field-test an audible back-up warning device for use on automobiles. Detailed criteria of pedestrian age and hearing ability combined with noise characteristics of typical accident sites provide the basis f...

At the Cosmonaut Hotel in Baikonur, Kazakhstan, Expedition 48-49 backup crewmember Peggy Whitson of NASA waters a tree in her name first planted in 2007 during traditional pre-launch activities June 30. Whitson is one of three backups to the prime crewmembers, Kate Rubins of NASA, Anatoly Ivanishin of Roscosmos and Takuya Onishi of the Japan Aerospace Exploration Agency, who will launch July 7, Baikonur time, on the Soyuz MS-01 spacecraft for a planned four-month mission on the International Space Station...NASA/Alexander Vysotsky.

NASA Image and Video Library

2016-06-30

At the Cosmonaut Hotel in Baikonur, Kazakhstan, Expedition 48-49 backup crewmember Peggy Whitson of NASA waters a tree in her name first planted in 2007 during traditional pre-launch activities June 30. Whitson is one of three backups to the prime crewmembers, Kate Rubins of NASA, Anatoly Ivanishin of Roscosmos and Takuya Onishi of the Japan Aerospace Exploration Agency, who will launch July 7, Baikonur time, on the Soyuz MS-01 spacecraft for a planned four-month mission on the International Space Station. NASA/Alexander Vysotsky

Influence of backup bearings and support structure dynamics on the behavior of rotors with active supports

NASA Technical Reports Server (NTRS)

Flowers, George T.

1994-01-01

Progress over the past year includes the following: A simplified rotor model with a flexible shaft and backup bearings has been developed. A simple rotor model which includes a flexible disk and bearings with clearance has been developed and the dynamics of the model investigated. A rotor model based upon the T-501 engine has been developed which includes backup bearing effects. Parallel simulation runs are being conducted using an ANSYS based finite element model of the T-501. The magnetic bearing test rig is currently floating and dynamics/control tests are being conducted. A paper has been written that documents the work using the T-501 engine model. Work has continued with the simplified model. The finite element model is currently being modified to include the effects of foundation dynamics. A literature search for material on foil bearings has been conducted. A finite element model is being developed for a magnetic bearing in series with a foil backup bearing.

Distributed intrusion monitoring system with fiber link backup and on-line fault diagnosis functions

NASA Astrophysics Data System (ADS)

Xu, Jiwei; Wu, Huijuan; Xiao, Shunkun

2014-12-01

A novel multi-channel distributed optical fiber intrusion monitoring system with smart fiber link backup and on-line fault diagnosis functions was proposed. A 1× N optical switch was intelligently controlled by a peripheral interface controller (PIC) to expand the fiber link from one channel to several ones to lower the cost of the long or ultra-long distance intrusion monitoring system and also to strengthen the intelligent monitoring link backup function. At the same time, a sliding window auto-correlation method was presented to identify and locate the broken or fault point of the cable. The experimental results showed that the proposed multi-channel system performed well especially whenever any a broken cable was detected. It could locate the broken or fault point by itself accurately and switch to its backup sensing link immediately to ensure the security system to operate stably without a minute idling. And it was successfully applied in a field test for security monitoring of the 220-km-length national borderline in China.

A hybrid data compression approach for online backup service

NASA Astrophysics Data System (ADS)

Wang, Hua; Zhou, Ke; Qin, MingKang

2009-08-01

With the popularity of Saas (Software as a service), backup service has becoming a hot topic of storage application. Due to the numerous backup users, how to reduce the massive data load is a key problem for system designer. Data compression provides a good solution. Traditional data compression application used to adopt a single method, which has limitations in some respects. For example data stream compression can only realize intra-file compression, de-duplication is used to eliminate inter-file redundant data, compression efficiency cannot meet the need of backup service software. This paper proposes a novel hybrid compression approach, which includes two levels: global compression and block compression. The former can eliminate redundant inter-file copies across different users, the latter adopts data stream compression technology to realize intra-file de-duplication. Several compressing algorithms were adopted to measure the compression ratio and CPU time. Adaptability using different algorithm in certain situation is also analyzed. The performance analysis shows that great improvement is made through the hybrid compression policy.

Minimizing distortion and internal forces in truss structures by simulated annealing

NASA Technical Reports Server (NTRS)

Kincaid, Rex K.

1989-01-01

Inaccuracies in the length of members and the diameters of joints of large truss reflector backup structures may produce unacceptable levels of surface distortion and member forces. However, if the member lengths and joint diameters can be measured accurately it is possible to configure the members and joints so that root-mean-square (rms) surface error and/or rms member forces is minimized. Following Greene and Haftka (1989) it is assumed that the force vector f is linearly proportional to the member length errors e(sub M) of dimension NMEMB (the number of members) and joint errors e(sub J) of dimension NJOINT (the number of joints), and that the best-fit displacement vector d is a linear function of f. Let NNODES denote the number of positions on the surface of the truss where error influences are measured. The solution of the problem is discussed. To classify, this problem was compared to a similar combinatorial optimization problem. In particular, when only the member length errors are considered, minimizing d(sup 2)(sub rms) is equivalent to the quadratic assignment problem. The quadratic assignment problem is a well known NP-complete problem in operations research literature. Hence minimizing d(sup 2)(sub rms) is is also an NP-complete problem. The focus of the research is the development of a simulated annealing algorithm to reduce d(sup 2)(sub rms). The plausibility of this technique is its recent success on a variety of NP-complete combinatorial optimization problems including the quadratic assignment problem. A physical analogy for simulated annealing is the way liquids freeze and crystallize. All computational experiments were done on a MicroVAX. The two interchange heuristic is very fast but produces widely varying results. The two and three interchange heuristic provides less variability in the final objective function values but runs much more slowly. Simulated annealing produced the best objective function values for every starting configuration and was faster than the two and three interchange heuristic.

BackUp: Development and evaluation of a smart-phone application for coping with suicidal crises

PubMed Central

Aerts, Saskia; Muijzers, Ekke; De Jaegere, Eva; van Heeringen, Kees; Portzky, Gwendolyn

2017-01-01

Background Suicide is a major public health issue and has large impact on the lives of many people. Innovative technologies such as smartphones could create new possibilities for suicide prevention, such as helping to overcome the barriers and stigma on help seeking in case of suicidal ideation. Due to their omnipresence, smartphone apps can offer suicide prevention tools very fast, they are easily-accessible, low-threshold and can help overcome some of the help-seeking barriers suicidal people experience. This article describes the development, testing and implementation of a mobile application for coping with suicidal crisis: BackUp. Methods Based on the analysis of literature and existing suicide prevention apps several tools were identified as relevant to include in a suicide prevention app. The selected tools (a safety planning tool, a hope box, a coping cards module, and a module to reach out) are evidence based in a face to face context, and could be easily transferred into a mobile app. The testing of existing apps and the literature also revealed important guidelines for the technical development of the application. Results BackUp was developed and tested by an expert panel (n = 9) and a panel of end users (n = 21). Both groups rated BackUp as valuable for suicide prevention. Suicidal ideation of the end user group was measured using the Beck Scale for Suicidal Ideation before and after testing BackUp, and showed a small but non-significant decrease. The majority of the testers used BackUp several times. All tools were evaluated as rather or very useable in times of suicidal crisis. Conclusion BackUp was positively evaluated and indicates that self-help tools can have a positive impact on suicidal ideation. Apps in particular create opportunities in approaching people that are not reached by traditional interventions; on the other hand they can contribute to suicide prevention in addition to regular care. However, more research is needed on the impact and effect of suicide prevention apps. PMID:28636617

LAMDA programmer`s manual. [Final report, Part 1

DOE Office of Scientific and Technical Information (OSTI.GOV)

Hughes, T.P.; Clark, R.M.; Mostrom, M.A.

This report discusses the following topics on the LAMDA program: General maintenance; CTSS FCL script; DOS batch files; Macintosh MPW scripts; UNICOS FCL script; VAX/MS command file; LINC calling tree; and LAMDA calling tree.

Expedition 32 Press Conference

NASA Image and Video Library

2012-07-13

Quarantined Expedition 32 Canadian backup crewmember Chris Hadfield, right, answers reporters questions from behind glass during a prelaunch press conference held at the Cosmonaut Hotel on Friday, July 13, 2012 in Baikonur, Kazakhstan. Seated next to him is Expedition 32 Russian backup crewmember Roman Romanenko. Photo Credit (NASA/Carla Cioffi)

WATER EGRESS

NASA Image and Video Library

1965-07-16

S65-28459 (16 July 1965) --- Astronaut Neil A. Armstrong, command pilot for the Gemini-5 backup crew, inside the Gemini Static Article 5 spacecraft prior to water egress training in the Gulf of Mexico. The training is part of the prelaunch schedule for prime and backup crew on the Gemini-5 mission.

Expedition 44 backup crew ESA (European Space Agency) astronaut Timothy Peake (left), Russian cosmonaut Yuri Malenchenko (ROSCOSMOS) (center), and NASA astronaut Timothy L. Kopra

NASA Image and Video Library

2015-02-19

JSC2015E053686 (04/30/2015) --- Expedition 44 backup crew ESA (European Space Agency) astronaut Timothy Peake (left), Russian cosmonaut Yuri Malenchenko (ROSCOSMOS) (center), and NASA astronaut Timothy L. Kopra .

Ceramic backup ring prevents undesirable weld-metal buildup

NASA Technical Reports Server (NTRS)

Leonard, G. E.

1971-01-01

Removable ceramic backup material butted against weld zone back prevents weld metal buildup at that site. Method is successful with manual tungsten-inert gas /TIG/ welding of 316 corrosion resistant steel /CRES/ pieces with 0.76 cm throat diameter and 1.57 cm pipe internal diameter.

PRELIMINARY DESIGN ANALYSIS OF AXIAL FLOW TURBINES

NASA Technical Reports Server (NTRS)

Glassman, A. J.

1994-01-01

A computer program has been developed for the preliminary design analysis of axial-flow turbines. Rapid approximate generalized procedures requiring minimum input are used to provide turbine overall geometry and performance adequate for screening studies. The computations are based on mean-diameter flow properties and a stage-average velocity diagram. Gas properties are assumed constant throughout the turbine. For any given turbine, all stages, except the first, are specified to have the same shape velocity diagram. The first stage differs only in the value of inlet flow angle. The velocity diagram shape depends upon the stage work factor value and the specified type of velocity diagram. Velocity diagrams can be specified as symmetrical, zero exit swirl, or impulse; or by inputting stage swirl split. Exit turning vanes can be included in the design. The 1991 update includes a generalized velocity diagram, a more flexible meanline path, a reheat model, a radial component of velocity, and a computation of free-vortex hub and tip velocity diagrams. Also, a loss-coefficient calibration was performed to provide recommended values for airbreathing engine turbines. Input design requirements include power or pressure ratio, mass flow rate, inlet temperature and pressure, and rotative speed. The design variables include inlet and exit diameters, stator angle or exit radius ratio, and number of stages. Gas properties are input as gas constant, specific heat ratio, and viscosity. The program output includes inlet and exit annulus dimensions, exit temperature and pressure, total and static efficiencies, flow angles, blading angles, and last stage absolute and relative Mach numbers. This program is written in FORTRAN 77 and can be ported to any computer with a standard FORTRAN compiler which supports NAMELIST. It was originally developed on an IBM 7000 series computer running VM and has been implemented on IBM PC computers and compatibles running MS-DOS under Lahey FORTRAN, and DEC VAX series computers running VMS. Format statements in the code may need to be rewritten depending on your FORTRAN compiler. The source code and sample data are available on a 5.25 inch 360K MS-DOS format diskette. This program was developed in 1972 and was last updated in 1991. IBM and IBM PC are registered trademarks of International Business Machines. MS-DOS is a registered trademark of Microsoft Corporation. DEC VAX, and VMS are trademarks of Digital Equipment Corporation.

ARCGRAPH SYSTEM - AMES RESEARCH GRAPHICS SYSTEM

NASA Technical Reports Server (NTRS)

Hibbard, E. A.

1994-01-01

Ames Research Graphics System, ARCGRAPH, is a collection of libraries and utilities which assist researchers in generating, manipulating, and visualizing graphical data. In addition, ARCGRAPH defines a metafile format that contains device independent graphical data. This file format is used with various computer graphics manipulation and animation packages at Ames, including SURF (COSMIC Program ARC-12381) and GAS (COSMIC Program ARC-12379). In its full configuration, the ARCGRAPH system consists of a two stage pipeline which may be used to output graphical primitives. Stage one is associated with the graphical primitives (i.e. moves, draws, color, etc.) along with the creation and manipulation of the metafiles. Five distinct data filters make up stage one. They are: 1) PLO which handles all 2D vector primitives, 2) POL which handles all 3D polygonal primitives, 3) RAS which handles all 2D raster primitives, 4) VEC which handles all 3D raster primitives, and 5) PO2 which handles all 2D polygonal primitives. Stage two is associated with the process of displaying graphical primitives on a device. To generate the various graphical primitives, create and reprocess ARCGRAPH metafiles, and access the device drivers in the VDI (Video Device Interface) library, users link their applications to ARCGRAPH's GRAFIX library routines. Both FORTRAN and C language versions of the GRAFIX and VDI libraries exist for enhanced portability within these respective programming environments. The ARCGRAPH libraries were developed on a VAX running VMS. Minor documented modification of various routines, however, allows the system to run on the following computers: Cray X-MP running COS (no C version); Cray 2 running UNICOS; DEC VAX running BSD 4.3 UNIX, or Ultrix; SGI IRIS Turbo running GL2-W3.5 and GL2-W3.6; Convex C1 running UNIX; Amhdahl 5840 running UTS; Alliant FX8 running UNIX; Sun 3/160 running UNIX (no native device driver); Stellar GS1000 running Stellex (no native device driver); and an SGI IRIS 4D running IRIX (no native device driver). Currently with version 7.0 of ARCGRAPH, the VDI library supports the following output devices: A VT100 terminal with a RETRO-GRAPHICS board installed, a VT240 using the Tektronix 4010 emulation capability, an SGI IRIS turbo using the native GL2 library, a Tektronix 4010, a Tektronix 4105, and the Tektronix 4014. ARCGRAPH version 7.0 was developed in 1988.

STS-9 payload specialist Merbold and backup Ockels in training session

NASA Technical Reports Server (NTRS)

1983-01-01

STS-9 payload specialist Ulf Merbold, right, a West German physicist and backup Wubbo Ockels, a Dutch scientist, are pictured in a training session in JSC's Shuttle mockup and integration laboratory. In this view Ockels appears to be showing Merbold how to operate a camera.

30 CFR 57.14132 - Horns and backup alarms for surface equipment.

Code of Federal Regulations, 2010 CFR

2010-07-01

... NONMETAL MINES Machinery and Equipment Safety Devices and Maintenance Requirements § 57.14132 Horns and backup alarms for surface equipment. (a) Manually-operated horns or other audible warning devices provided on self-propelled mobile equipment as a safety device shall be maintained in a functional...

75 FR 70294 - Notice of Determinations Regarding Eligibility To Apply for Worker Adjustment Assistance

Federal Register 2010, 2011, 2012, 2013, 2014

2010-11-17

... Corporation Including Express Employment Professionals. 74,111 Alstom Transportation, Hornell, NY May 14, 2009... Serv., Server Systems, IC1, Storage, Backup. 74,316A International Business Cambridge, MA......... June 10, 2009. Machines (IBM), Global Tech Serv., Server Systems, IC1, Storage, Backup. 74,316B...

26 CFR 31.3406-0 - Outline of the backup withholding regulations.

Code of Federal Regulations, 2013 CFR

2013-04-01

... incorrect name/TIN combination. (2) Definition of account. (3) Definition of business day. (4) Certain exceptions. (c) Notice regarding an incorrect name/TIN combination. (1) In general. (2) Additional... of receipt. (d) Notice from payors of backup withholding due to an incorrect name/TIN combination. (1...

75 FR 61655 - Airworthiness Directives; Piper Aircraft, Inc. Model PA-28-161 Airplanes

Federal Register 2010, 2011, 2012, 2013, 2014

2010-10-06

... (FADEC) backup battery, replacing the supplement pilot's operating handbook and FAA approved airplane... can allow the FADEC to shut down or reset if the main battery is depleted and the electrical charging... service information describes procedures for installation of a FADEC backup battery. FAA's Determination...

ASSIST - THE ABSTRACT SEMI-MARKOV SPECIFICATION INTERFACE TO THE SURE TOOL PROGRAM (SUN VERSION)

NASA Technical Reports Server (NTRS)

Johnson, S. C.

1994-01-01

ASSIST, the Abstract Semi-Markov Specification Interface to the SURE Tool program, is an interface that will enable reliability engineers to accurately design large semi-Markov models. The user describes the failure behavior of a fault-tolerant computer system in an abstract, high-level language. The ASSIST program then automatically generates a corresponding semi-Markov model. The abstract language allows efficient description of large, complex systems; a one-page ASSIST-language description may result in a semi-Markov model with thousands of states and transitions. The ASSIST program also includes model-reduction techniques to facilitate efficient modeling of large systems. Instead of listing the individual states of the Markov model, reliability engineers can specify the rules governing the behavior of a system, and these are used to automatically generate the model. ASSIST reads an input file describing the failure behavior of a system in an abstract language and generates a Markov model in the format needed for input to SURE, the semi-Markov Unreliability Range Evaluator program, and PAWS/STEM, the Pade Approximation with Scaling program and Scaled Taylor Exponential Matrix. A Markov model consists of a number of system states and transitions between them. Each state in the model represents a possible state of the system in terms of which components have failed, which ones have been removed, etc. Within ASSIST, each state is defined by a state vector, where each element of the vector takes on an integer value within a defined range. An element can represent any meaningful characteristic, such as the number of working components of one type in the system, or the number of faulty components of another type in use. Statements representing transitions between states in the model have three parts: a condition expression, a destination expression, and a rate expression. The first expression is a Boolean expression describing the state space variable values of states for which the transition is valid. The second expression defines the destination state for the transition in terms of state space variable values. The third expression defines the distribution of elapsed time for the transition. The mathematical approach chosen to solve a reliability problem may vary with the size and nature of the problem. Although different solution techniques are utilized on different programs, it is possible to have a common input language. The Systems Validation Methods group at NASA Langley Research Center has created a set of programs that form the basis for a reliability analysis workstation. The set of programs are: SURE reliability analysis program (COSMIC program LAR-13789, LAR-14921); the ASSIST specification interface program (LAR-14193, LAR-14923), PAWS/STEM reliability analysis programs (LAR-14165, LAR-14920); and the FTC fault tree tool (LAR-14586, LAR-14922). FTC is used to calculate the top-event probability for a fault tree. PAWS/STEM and SURE are programs which interpret the same SURE language, but utilize different solution methods. ASSIST is a preprocessor that generates SURE language from a more abstract definition. SURE, ASSIST, and PAWS/STEM are also offered as a bundle. Please see the abstract for COS-10039/COS-10041, SARA - SURE/ASSIST Reliability Analysis Workstation, for pricing details. ASSIST was originally developed for DEC VAX series computers running VMS and was later ported for use on Sun computers running SunOS. The VMS version (LAR14193) is written in C-language and can be compiled with the VAX C compiler. The standard distribution medium for the VMS version of ASSIST is a 9-track 1600 BPI magnetic tape in VMSINSTAL format. It is also available on a TK50 tape cartridge in VMSINSTAL format. Executables are included. The Sun version (LAR14923) is written in ANSI C-language. An ANSI compliant C compiler is required in order to compile this package. The standard distribution medium for the Sun version of ASSIST is a .25 inch streaming magnetic tape cartridge in UNIX tar format. Both Sun3 and Sun4 executables are included. Electronic copies of the documentation in PostScript, TeX, and DVI formats are provided on the distribution medium. (The VMS distribution lacks the .DVI format files, however.) ASSIST was developed in 1986 and last updated in 1992. DEC, VAX, VMS, and TK50 are trademarks of Digital Equipment Corporation. SunOS, Sun3, and Sun4 are trademarks of Sun Microsystems, Inc. UNIX is a registered trademark of AT&T Bell Laboratories.

POMESH - DIFFRACTION ANALYSIS OF REFLECTOR ANTENNAS

NASA Technical Reports Server (NTRS)

Hodges, R. E.

1994-01-01

POMESH is a computer program capable of predicting the performance of reflector antennas. Both far field pattern and gain calculations are performed using the Physical Optics (PO) approximation of the equivalent surface currents. POMESH is primarily intended for relatively small reflectors. It is useful in situations where the surface is described by irregular data that must be interpolated and for cases where the surface derivatives are not known. This method is flexible and robust and also supports near field calculations. Because of the near field computation ability, this computational engine is quite useful for subreflector computations. The program is constructed in a highly modular form so that it may be readily adapted to perform tasks other than the one that is explicitly described here. Since the computationally intensive portions of the algorithm are simple loops, the program can be easily adapted to take advantage of vector processor and parallel architectures. In POMESH the reflector is represented as a piecewise planar surface comprised of triangular regions known as facets. A uniform physical optics (PO) current is assumed to exist on each triangular facet. Then, the PO integral on a facet is approximated by the product of the PO current value at the center and the area of the triangle. In this way, the PO integral over the reflector surface is reduced to a summation of the contribution from each triangular facet. The source horn, or feed, that illuminates the subreflector is approximated by a linear combination of plane patterns. POMESH contains three polarization pattern definitions for the feed; a linear x-polarized element, linear y-polarized element, and a circular polarized element. If a more general feed pattern is required, it is a simple matter to replace the subroutine that implements the pattern definitions. POMESH obtains information necessary to specify the coordinate systems, location of other data files, and parameters of the desired calculation from a user provided data file. A numerical description of the principle plane patterns of the source horn must also be provided. The program is supplied with an analytically defined parabolic reflector surface. However, it is a simple matter to replace it with a user defined reflector surface. Output is given in the form of a data stream to the terminal; a summary of the parameters used in the computation and some sample results in a file; and a data file of the results of the pattern calculations suitable for plotting. POMESH is written in FORTRAN 77 for execution on CRAY series computers running UNICOS. With minor modifications, it has also been successfully implemented on a Sun4 series computer running SunOS, a DEC VAX series computer running VMS, and an IBM PC series computer running OS/2. It requires 2.5Mb of RAM under SunOS 4.1.1, 2.5Mb of RAM under VMS 5-4.3, and 2.5Mb of RAM under OS/2. The OS/2 version requires the Lahey F77L compiler. The standard distribution medium for this program is one 5.25 inch 360K MS-DOS format diskette. It is also available on a .25 inch streaming magnetic tape cartridge in UNIX tar format and a 9-track 1600 BPI magnetic tape in DEC VAX FILES-11 format. POMESH was developed in 1989 and is a copyrighted work with all copyright vested in NASA. CRAY and UNICOS are registered trademarks of Cray Research, Inc. SunOS and Sun4 are trademarks of Sun Microsystems, Inc. DEC, DEC FILES-11, VAX and VMS are trademarks of Digital Equipment Corporation. IBM PC and OS/2 are registered trademarks of International Business Machines, Inc. UNIX is a registered trademark of Bell Laboratories.

SURE - SEMI-MARKOV UNRELIABILITY RANGE EVALUATOR (VAX VMS VERSION)

NASA Technical Reports Server (NTRS)

Butler, R. W.

1994-01-01

The Semi-Markov Unreliability Range Evaluator, SURE, is an analysis tool for reconfigurable, fault-tolerant systems. Traditional reliability analyses are based on aggregates of fault-handling and fault-occurrence models. SURE provides an efficient means for calculating accurate upper and lower bounds for the death state probabilities for a large class of semi-Markov models, not just those which can be reduced to critical-pair architectures. The calculated bounds are close enough (usually within 5 percent of each other) for use in reliability studies of ultra-reliable computer systems. The SURE bounding theorems have algebraic solutions and are consequently computationally efficient even for large and complex systems. SURE can optionally regard a specified parameter as a variable over a range of values, enabling an automatic sensitivity analysis. Highly reliable systems employ redundancy and reconfiguration as methods of ensuring operation. When such systems are modeled stochastically, some state transitions are orders of magnitude faster than others; that is, fault recovery is usually faster than fault arrival. SURE takes these time differences into account. Slow transitions are described by exponential functions and fast transitions are modeled by either the White or Lee theorems based on means, variances, and percentiles. The user must assign identifiers to every state in the system and define all transitions in the semi-Markov model. SURE input statements are composed of variables and constants related by FORTRAN-like operators such as =, +, *, SIN, EXP, etc. There are a dozen major commands such as READ, READO, SAVE, SHOW, PRUNE, TRUNCate, CALCulator, and RUN. Once the state transitions have been defined, SURE calculates the upper and lower probability bounds for entering specified death states within a specified mission time. SURE output is tabular. The mathematical approach chosen to solve a reliability problem may vary with the size and nature of the problem. Although different solution techniques are utilized on different programs, it is possible to have a common input language. The Systems Validation Methods group at NASA Langley Research Center has created a set of programs that form the basis for a reliability analysis workstation. The set of programs are: SURE reliability analysis program (COSMIC program LAR-13789, LAR-14921); the ASSIST specification interface program (LAR-14193, LAR-14923), PAWS/STEM reliability analysis programs (LAR-14165, LAR-14920); and the FTC fault tree tool (LAR-14586, LAR-14922). FTC is used to calculate the top-event probability for a fault tree. PAWS/STEM and SURE are programs which interpret the same SURE language, but utilize different solution methods. ASSIST is a preprocessor that generates SURE language from a more abstract definition. SURE, ASSIST, and PAWS/STEM are also offered as a bundle. Please see the abstract for COS-10039/COS-10041, SARA - SURE/ASSIST Reliability Analysis Workstation, for pricing details. SURE was originally developed for DEC VAX series computers running VMS and was later ported for use on Sun computers running SunOS. The VMS version (LAR13789) is written in PASCAL, C-language, and FORTRAN 77. The standard distribution medium for the VMS version of SURE is a 9-track 1600 BPI magnetic tape in VMSINSTAL format. It is also available on a TK50 tape cartridge in VMSINSTAL format. Executables are included. The Sun UNIX version (LAR14921) is written in ANSI C-language and PASCAL. An ANSI compliant C compiler is required in order to compile the C portion of this package. The standard distribution medium for the Sun version of SURE is a .25 inch streaming magnetic tape cartridge in UNIX tar format. Both Sun3 and Sun4 executables are included. SURE was developed in 1988 and last updated in 1992. DEC, VAX, VMS, and TK50 are trademarks of Digital Equipment Corporation. TEMPLATE is a registered trademark of Template Graphics Software, Inc. UNIX is a registered trademark of AT&T Bell Laboratories. Sun3 and Sun4 are trademarks of Sun Microsystems, Inc.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Not Available

This manual is a guide to use of the file protection mechanisms available on the Martin Marietta Energy Systems, Inc. KSV VAXes. User identification codes (UICs) and general identifiers are discussed as a basis for understanding UIC-based and access control list (ACL) protection.

SIG: a general-purpose signal processing program

DOE Office of Scientific and Technical Information (OSTI.GOV)

Lager, D.; Azevedo, S.

1986-02-01

SIG is a general-purpose signal processing, analysis, and display program. Its main purpose is to perform manipulations on time- and frequency-domain signals. It also accommodates other representations for data such as transfer function polynomials. Signal processing operations include digital filtering, auto/cross spectral density, transfer function/impulse response, convolution, Fourier transform, and inverse Fourier transform. Graphical operations provide display of signals and spectra, including plotting, cursor zoom, families of curves, and multiple viewport plots. SIG provides two user interfaces with a menu mode for occasional users and a command mode for more experienced users. Capability exits for multiple commands per line, commandmore » files with arguments, commenting lines, defining commands, automatic execution for each item in a repeat sequence, etc. SIG is presently available for VAX(VMS), VAX (BERKELEY 4.2 UNIX), SUN (BERKELEY 4.2 UNIX), DEC-20 (TOPS-20), LSI-11/23 (TSX), and DEC PRO 350 (TSX). 4 refs., 2 figs.« less

Fault latency in the memory - An experimental study on VAX 11/780

NASA Technical Reports Server (NTRS)

Chillarege, Ram; Iyer, Ravishankar K.

1986-01-01

Fault latency is the time between the physical occurrence of a fault and its corruption of data, causing an error. The measure of this time is difficult to obtain because the time of occurrence of a fault and the exact moment of generation of an error are not known. This paper describes an experiment to accurately study the fault latency in the memory subsystem. The experiment employs real memory data from a VAX 11/780 at the University of Illinois. Fault latency distributions are generated for s-a-0 and s-a-1 permanent fault models. Results show that the mean fault latency of a s-a-0 fault is nearly 5 times that of the s-a-1 fault. Large variations in fault latency are found for different regions in memory. An analysis of a variance model to quantify the relative influence of various workload measures on the evaluated latency is also given.

Running SINDA '85/FLUINT interactive on the VAX

NASA Technical Reports Server (NTRS)

Simmonds, Boris

1992-01-01

Computer software as engineering tools are typically run in three modes: Batch, Demand, and Interactive. The first two are the most popular in the SINDA world. The third one is not so popular, due probably to the users inaccessibility to the command procedure files for running SINDA '85, or lack of familiarity with the SINDA '85 execution processes (pre-processor, processor, compilation, linking, execution and all of the file assignment, creation, deletions and de-assignments). Interactive is the mode that makes thermal analysis with SINDA '85 a real-time design tool. This paper explains a command procedure sufficient (the minimum modifications required in an existing demand command procedure) to run SINDA '85 on the VAX in an interactive mode. To exercise the procedure a sample problem is presented exemplifying the mode, plus additional programming capabilities available in SINDA '85. Following the same guidelines the process can be extended to other SINDA '85 residence computer platforms.

A graphical language for reliability model generation

NASA Technical Reports Server (NTRS)

Howell, Sandra V.; Bavuso, Salvatore J.; Haley, Pamela J.

1990-01-01

A graphical interface capability of the hybrid automated reliability predictor (HARP) is described. The graphics-oriented (GO) module provides the user with a graphical language for modeling system failure modes through the selection of various fault tree gates, including sequence dependency gates, or by a Markov chain. With this graphical input language, a fault tree becomes a convenient notation for describing a system. In accounting for any sequence dependencies, HARP converts the fault-tree notation to a complex stochastic process that is reduced to a Markov chain which it can then solve for system reliability. The graphics capability is available for use on an IBM-compatible PC, a Sun, and a VAX workstation. The GO module is written in the C programming language and uses the Graphical Kernel System (GKS) standard for graphics implementation. The PC, VAX, and Sun versions of the HARP GO module are currently in beta-testing.

[Russian treadmill BD-1 as a backup of the NASA TVIS].

PubMed

Iarmanova, E N; Kozlovskaia, I B; Bogomolov, V V; Rumiantseva, O N; Sukhachev, V I; Mel'nik, K A

2006-01-01

Already during the early ISS increments malfunctioning of NASA TVIS (treadmill with vibration isolation system) posed major problems for regular crew training and particularly scamper, one of the key exercises on the Russian physical training program. During ISS increment-3, TVIS unscheduled repairs took virtually all the training time. In search for TVIS backup, Russian and NASA engineers considered jointly Russian treadmill BD-1, originally designed for Russian "shuttle" Buran and accepted it as a suitable backup in case of complete TVIS failure. To enter into the "dialogue" with BD-1, i.e., to record and downlink training data, the treadmill speed indicator, a part of the treadmill stand, was replaced by PC.

jsc2013e080238

NASA Image and Video Library

2013-09-06

At the Kremlin Wall at Red Square in Moscow, Five of the six Expedition 37/38 prime and backup crewmembers pose for pictures Sept. 6 during the traditional visit to lay flowers at the wall where Russian space icons are interred. With the onion domed spires of St. Basil’s Cathedral in the background, from left to right are backup NASA Flight Engineer Steve Swanson, prime Flight Engineer Michael Hopkins of NASA, prime Soyuz Commander Oleg Kotov, prime Flight Engineer Sergey Ryazanskiy and backup Flight Engineer Oleg Artemyev. Hopkins, Kotov and Ryazanskiy are preparing for their launch to the International Space Station from the Baikonur Cosmodrome in Kazakhstan on Sept. 26, Kazakh time, aboard the Soyuz TMA-10M spacecraft. NASA/Stephanie Stoll

Mathematical defense method of networked servers with controlled remote backups

NASA Astrophysics Data System (ADS)

Kim, Song-Kyoo

2006-05-01

The networked server defense model is focused on reliability and availability in security respects. The (remote) backup servers are hooked up by VPN (Virtual Private Network) with high-speed optical network and replace broken main severs immediately. The networked server can be represent as "machines" and then the system deals with main unreliable, spare, and auxiliary spare machine. During vacation periods, when the system performs a mandatory routine maintenance, auxiliary machines are being used for back-ups; the information on the system is naturally delayed. Analog of the N-policy to restrict the usage of auxiliary machines to some reasonable quantity. The results are demonstrated in the network architecture by using the stochastic optimization techniques.

Current oral contraceptive use instructions: an analysis of patient package inserts.

PubMed

Williams-Deane, M; Potter, L S

1992-01-01

Oral contraceptive use instructions contained in manufacturers' patient package inserts (PPIs) are often inconsistent or conflicting, both among manufacturers and among different brands and regimens from the same manufacturer. Instructions on what to do about missed pills are often incomplete or inadequate, as are instructions on backup contraceptive use when pills are missed. The format of many PPIs is confusing and makes instructions difficult to find and read. Comprehending the PPIs requires the user to read at a 10th-12th-grade level, far higher than the generally accepted 5th-6th grade level considered standard for health education materials.

Low Multiplicity of HIV-1 Infection and No Vaccine Enhancement in VAX003 Injection Drug Users

PubMed Central

Sterrett, Sarah; Learn, Gerald H.; Edlefsen, Paul T.; Haynes, Barton F.; Hahn, Beatrice H.; Shaw, George M.; Bar, Katharine J.

2014-01-01

Background  We performed human immunodeficiency virus type 1 (HIV-1) transmitted/founder (T/F) virus analysis of the VAX003 vaccine efficacy trial participants to characterize the transmission bottleneck and test for vaccine-associated reduction or enhancement of infection in this injection drug user (IDU) cohort. Methods  We performed single genome sequencing of plasma vRNA from 50 subjects sampled in early HIV infection. Sequences were analyzed phylogenetically, T/F viruses enumerated, and a sieve analysis performed. Results  Eight of 19 (42%) placebo recipients were productively infected by more than 1 virus (range 1–5, median 1, mean 1.7). This frequency of multiple virus transmission was greater than reported for heterosexual cohorts (19%, P = .03) but not statistically different from vaccine recipients (22.6%, P > .05), where the range was 1–3, median 1, and mean 1.3 (P > .05 for all comparisons). An atypical sieve effect was detected in Env V2 but was not associated with reduction or enhancement of virus acquisition. Conclusions  The number of T/F viruses in IDUs was surprising low, with 95% of individuals infected by only 1–3 viruses. This finding suggests that a successful vaccine or other prevention modality generally needs to protect against only one or a few viruses regardless of risk behavior. T/F analysis identified an atypical genetic sieve in the V2 region of Envelope and found no evidence for vaccine-mediated enhancement in VAX003. PMID:25734126

Thermostable ricin vaccine protects rhesus macaques against aerosolized ricin: Epitope-specific neutralizing antibodies correlate with protection.

PubMed

Roy, Chad J; Brey, Robert N; Mantis, Nicholas J; Mapes, Kelly; Pop, Iliodora V; Pop, Laurentiu M; Ruback, Stephen; Killeen, Stephanie Z; Doyle-Meyers, Lara; Vinet-Oliphant, Heather S; Didier, Peter J; Vitetta, Ellen S

2015-03-24

Ricin toxin (RT) is the second most lethal toxin known; it has been designated by the CDC as a select agent. RT is made by the castor bean plant; an estimated 50,000 tons of RT are produced annually as a by-product of castor oil. RT has two subunits, a ribotoxic A chain (RTA) and galactose-binding B chain (RTB). RT binds to all mammalian cells and once internalized, a single RTA catalytically inactivates all of the ribosomes in a cell. Administered as an aerosol, RT causes rapid lung damage and fibrosis followed by death. There are no Food and Drug Administration-approved vaccines and treatments are only effective in the first few hours after exposure. We have developed a recombinant RTA vaccine that has two mutations V76M/Y80A (RiVax). The protein is expressed in Escherichia coli and is nontoxic and immunogenic in mice, rabbits, and humans. When vaccinated mice are challenged with injected, aerosolized, or orally administered (gavaged) RT, they are completely protected. We have now developed a thermostable, aluminum-adjuvant-containing formulation of RiVax and tested it in rhesus macaques. After three injections, the animals developed antibodies that completely protected them from a lethal dose of aerosolized RT. These antibodies neutralized RT and competed to varying degrees with a panel of neutralizing and nonneutralizing mouse monoclonal antibodies known to recognize specific epitopes on native RTA. The resulting antibody competition profile could represent an immunologic signature of protection. Importantly, the same signature was observed using sera from RiVax-immunized humans.

Autonomous sensor-based dual-arm satellite grappling

NASA Technical Reports Server (NTRS)

Wilcox, Brian; Tso, Kam; Litwin, Todd; Hayati, Samad; Bon, Bruce

1989-01-01

Dual-arm satellite grappling involves the integration of technologies developed in the Sensing and Perception (S&P) Subsystem for object acquisition and tracking, and the Manipulator Control and Mechanization (MCM) Subsystem for dual-arm control. S&P acquires and tracks the position, orientation, velocity, and angular velocity of a slowly spinning satellite, and sends tracking data to the MCM subsystem. MCM grapples the satellite and brings it to rest, controlling the arms so that no excessive forces or torques are exerted on the satellite or arms. A 350-pound satellite mockup which can spin freely on a gimbal for several minutes, closely simulating the dynamics of a real satellite is demonstrated. The satellite mockup is fitted with a panel under which may be mounted various elements such as line replacement modules and electrical connectors that will be used to demonstrate servicing tasks once the satellite is docked. The subsystems are housed in three MicroVAX II microcomputers. The hardware of the S&P Subsystem includes CCD cameras, video digitizers, frame buffers, IMFEX (a custom pipelined video processor), a time-code generator with millisecond precision, and a MicroVAX II computer. Its software is written in Pascal and is based on a locally written vision software library. The hardware of the MCM Subsystem includes PUMA 560 robot arms, Lord force/torque sensors, two MicroVAX II computers, and unimation pneumatic parallel grippers. Its software is written in C, and is based on a robot language called RCCL. The two subsystems are described and test results on the grappling of the satellite mockup with rotational rates of up to 2 rpm are provided.

Understanding the Dimensions of Anti-Vaccination Attitudes: the Vaccination Attitudes Examination (VAX) Scale.

PubMed

Martin, Leslie R; Petrie, Keith J

2017-10-01

Anti-vaccination attitudes are important predictors of vaccination behavior. Existing measures of vaccination attitudes focus on specific age groups and/or particular vaccines; a more comprehensive measure would facilitate comparisons across studies. The aim of this study was to develop a short measure of general vaccination attitudes and establish its reliability and validity. Two studies were conducted using the VAX scale. For Study 1, participants were 409 individuals (53% female), with a mean age of 34.5 years. For Study 2, participants were 92 individuals (67% female) with a mean age of 28.6. Participants answered paper-and-pencil questions about their attitudes toward vaccines, prior and expected-future vaccination behaviors, perceived sensitivity to medicines, online behavior, and basic demographic information. Exploratory and confirmatory factor analyses were conducted with correlations and t tests then used to assess the scale's reliability and validity. Four distinct but correlated vaccine attitudes were identified: (1) mistrust of vaccine benefit, (2) worries about unforeseen future effects, (3) concerns about commercial profiteering, and (4) preference for natural immunity. These factors were significantly related to prior vaccination behavior, future intentions to obtain recommended vaccinations, perceived sensitivity to medicines, and the tendency to obtain health information online. The VAX scale provides an efficient method for identifying those with vaccination resistance, and the four subscales enable a more nuanced understanding of the nature of those views. It should be noted, however, that the strong correlations amongst the four subscales suggest that interventions should target all four attitude areas, and it remains to be seen whether differential emphasis across the four areas is warranted.

Active Idiotypic Vaccination Versus Control Immunotherapy for Follicular Lymphoma

PubMed Central

Levy, Ronald; Ganjoo, Kristen N.; Leonard, John P.; Vose, Julie M.; Flinn, Ian W.; Ambinder, Richard F.; Connors, Joseph M.; Berinstein, Neil L.; Belch, Andrew R.; Bartlett, Nancy L.; Nichols, Craig; Emmanouilides, Christos E.; Timmerman, John M.; Gregory, Stephanie A.; Link, Brian K.; Inwards, David J.; Freedman, Arnold S.; Matous, Jeffrey V.; Robertson, Michael J.; Kunkel, Lori A.; Ingolia, Diane E.; Gentles, Andrew J.; Liu, Chih Long; Tibshirani, Robert; Alizadeh, Ash A.; Denney, Dan W.

2014-01-01

Purpose Idiotypes (Ids), the unique portions of tumor immunoglobulins, can serve as targets for passive and active immunotherapies for lymphoma. We performed a multicenter, randomized trial comparing a specific vaccine (MyVax), comprising Id chemically coupled to keyhole limpet hemocyanin (KLH) plus granulocyte macrophage colony-stimulating factor (GM-CSF) to a control immunotherapy with KLH plus GM-CSF. Patients and Methods Patients with previously untreated advanced-stage follicular lymphoma (FL) received eight cycles of chemotherapy with cyclophosphamide, vincristine, and prednisone. Those achieving sustained partial or complete remission (n = 287 [44%]) were randomly assigned at a ratio of 2:1 to receive one injection per month for 7 months of MyVax or control immunotherapy. Anti-Id antibody responses (humoral immune responses [IRs]) were measured before each immunization. The primary end point was progression-free survival (PFS). Secondary end points included IR and time to subsequent antilymphoma therapy. Results At a median follow-up of 58 months, no significant difference was observed in either PFS or time to next therapy between the two arms. In the MyVax group (n = 195), anti-Id IRs were observed in 41% of patients, with a median PFS of 40 months, significantly exceeding the median PFS observed in patients without such Id-induced IRs and in those receiving control immunotherapy. Conclusion This trial failed to demonstrate clinical benefit of specific immunotherapy. The subset of vaccinated patients mounting specific anti-Id responses had superior outcomes. Whether this reflects a therapeutic benefit or is a marker for more favorable underlying prognosis requires further study. PMID:24799467

38 CFR 17.230 - Contingency backup to the Department of Defense.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 38 Pensions, Bonuses, and Veterans' Relief 1 2010-07-01 2010-07-01 false Contingency backup to the Department of Defense. 17.230 Section 17.230 Pensions, Bonuses, and Veterans' Relief DEPARTMENT OF VETERANS... the Department of Defense. (a) Priority care to active duty personnel. The Secretary, during and/or...

38 CFR 17.230 - Contingency backup to the Department of Defense.

Code of Federal Regulations, 2011 CFR

2011-07-01

... 38 Pensions, Bonuses, and Veterans' Relief 1 2011-07-01 2011-07-01 false Contingency backup to the Department of Defense. 17.230 Section 17.230 Pensions, Bonuses, and Veterans' Relief DEPARTMENT OF VETERANS... the Department of Defense. (a) Priority care to active duty personnel. The Secretary, during and/or...

38 CFR 17.230 - Contingency backup to the Department of Defense.

Code of Federal Regulations, 2012 CFR

2012-07-01

... 38 Pensions, Bonuses, and Veterans' Relief 1 2012-07-01 2012-07-01 false Contingency backup to the Department of Defense. 17.230 Section 17.230 Pensions, Bonuses, and Veterans' Relief DEPARTMENT OF VETERANS... the Department of Defense. (a) Priority care to active duty personnel. The Secretary, during and/or...

38 CFR 17.230 - Contingency backup to the Department of Defense.

Code of Federal Regulations, 2014 CFR

2014-07-01

... 38 Pensions, Bonuses, and Veterans' Relief 1 2014-07-01 2014-07-01 false Contingency backup to the Department of Defense. 17.230 Section 17.230 Pensions, Bonuses, and Veterans' Relief DEPARTMENT OF VETERANS... the Department of Defense. (a) Priority care to active duty personnel. The Secretary, during and/or...

38 CFR 17.230 - Contingency backup to the Department of Defense.

Code of Federal Regulations, 2013 CFR

2013-07-01

... 38 Pensions, Bonuses, and Veterans' Relief 1 2013-07-01 2013-07-01 false Contingency backup to the Department of Defense. 17.230 Section 17.230 Pensions, Bonuses, and Veterans' Relief DEPARTMENT OF VETERANS... the Department of Defense. (a) Priority care to active duty personnel. The Secretary, during and/or...

30 CFR 75.1101-21 - Back-up water system.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 30 Mineral Resources 1 2010-07-01 2010-07-01 false Back-up water system. 75.1101-21 Section 75.1101-21 Mineral Resources MINE SAFETY AND HEALTH ADMINISTRATION, DEPARTMENT OF LABOR COAL MINE SAFETY... water system. One fire hose outlet together with a length of hose capable of extending to the belt drive...

30 CFR 75.1101-21 - Back-up water system.

Code of Federal Regulations, 2011 CFR

2011-07-01

... 30 Mineral Resources 1 2011-07-01 2011-07-01 false Back-up water system. 75.1101-21 Section 75.1101-21 Mineral Resources MINE SAFETY AND HEALTH ADMINISTRATION, DEPARTMENT OF LABOR COAL MINE SAFETY... water system. One fire hose outlet together with a length of hose capable of extending to the belt drive...

77 FR 28797 - Redundancy of Communications Systems: Backup Power Private Land Mobile Radio Services: Selection...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-05-16

... Systems: Backup Power Private Land Mobile Radio Services: Selection and Assignment of Frequencies, and... certain rule provisions that are without current legal effect and obsolete. These nonsubstantive revisions... current legal effect and is deleted as obsolete. 2. This Order also deletes a rule providing that UHF...

30 CFR 75.1101-21 - Back-up water system.

Code of Federal Regulations, 2014 CFR

2014-07-01

... 30 Mineral Resources 1 2014-07-01 2014-07-01 false Back-up water system. 75.1101-21 Section 75.1101-21 Mineral Resources MINE SAFETY AND HEALTH ADMINISTRATION, DEPARTMENT OF LABOR COAL MINE SAFETY... water system. One fire hose outlet together with a length of hose capable of extending to the belt drive...

30 CFR 75.1101-21 - Back-up water system.

Code of Federal Regulations, 2012 CFR

2012-07-01

... 30 Mineral Resources 1 2012-07-01 2012-07-01 false Back-up water system. 75.1101-21 Section 75.1101-21 Mineral Resources MINE SAFETY AND HEALTH ADMINISTRATION, DEPARTMENT OF LABOR COAL MINE SAFETY... water system. One fire hose outlet together with a length of hose capable of extending to the belt drive...

30 CFR 75.1101-21 - Back-up water system.

Code of Federal Regulations, 2013 CFR

2013-07-01

... 30 Mineral Resources 1 2013-07-01 2013-07-01 false Back-up water system. 75.1101-21 Section 75.1101-21 Mineral Resources MINE SAFETY AND HEALTH ADMINISTRATION, DEPARTMENT OF LABOR COAL MINE SAFETY... water system. One fire hose outlet together with a length of hose capable of extending to the belt drive...

78 FR 63263 - Self-Regulatory Organizations; The Options Clearing Corporation; Order Approving Proposed Rule...

Federal Register 2010, 2011, 2012, 2013, 2014

2013-10-23

... Adopted Under Rule 205 Entitled ``Back-Up Communication Channel to Internet Access'' October 17, 2013. I... ``Back-up Communication Channel to Internet Access'' requiring clearing members that use the internet as... Policy Statement under Rule 205 requiring clearing members that primarily use the internet to access OCC...

The depth of the honeybee's backup sun-compass systems.

PubMed

Dovey, Katelyn M; Kemfort, Jordan R; Towne, William F

2013-06-01

Honeybees have at least three compass mechanisms: a magnetic compass; a celestial or sun compass, based on the daily rotation of the sun and sun-linked skylight patterns; and a backup celestial compass based on a memory of the sun's movements over time in relation to the landscape. The interactions of these compass systems have yet to be fully elucidated, but the celestial compass is primary in most contexts, the magnetic compass is a backup in certain contexts, and the bees' memory of the sun's course in relation to the landscape is a backup system for cloudy days. Here we ask whether bees have any further compass systems, for example a memory of the sun's movements over time in relation to the magnetic field. To test this, we challenged bees to locate the sun when their known celestial compass systems were unavailable, that is, under overcast skies in unfamiliar landscapes. We measured the bees' knowledge of the sun's location by observing their waggle dances, by which foragers indicate the directions toward food sources in relation to the sun's compass bearing. We found that bees have no celestial compass systems beyond those already known: under overcast skies in unfamiliar landscapes, bees attempt to use their landscape-based backup system to locate the sun, matching the landscapes or skylines at the test sites with those at their natal sites as best they can, even if the matches are poor and yield weak or inconsistent orientation.

An approach to secure weather and climate models against hardware faults

NASA Astrophysics Data System (ADS)

Düben, Peter D.; Dawson, Andrew

2017-03-01

Enabling Earth System models to run efficiently on future supercomputers is a serious challenge for model development. Many publications study efficient parallelization to allow better scaling of performance on an increasing number of computing cores. However, one of the most alarming threats for weather and climate predictions on future high performance computing architectures is widely ignored: the presence of hardware faults that will frequently hit large applications as we approach exascale supercomputing. Changes in the structure of weather and climate models that would allow them to be resilient against hardware faults are hardly discussed in the model development community. In this paper, we present an approach to secure the dynamical core of weather and climate models against hardware faults using a backup system that stores coarse resolution copies of prognostic variables. Frequent checks of the model fields on the backup grid allow the detection of severe hardware faults, and prognostic variables that are changed by hardware faults on the model grid can be restored from the backup grid to continue model simulations with no significant delay. To justify the approach, we perform model simulations with a C-grid shallow water model in the presence of frequent hardware faults. As long as the backup system is used, simulations do not crash and a high level of model quality can be maintained. The overhead due to the backup system is reasonable and additional storage requirements are small. Runtime is increased by only 13 % for the shallow water model.

An approach to secure weather and climate models against hardware faults

NASA Astrophysics Data System (ADS)

Düben, Peter; Dawson, Andrew

2017-04-01

Enabling Earth System models to run efficiently on future supercomputers is a serious challenge for model development. Many publications study efficient parallelisation to allow better scaling of performance on an increasing number of computing cores. However, one of the most alarming threats for weather and climate predictions on future high performance computing architectures is widely ignored: the presence of hardware faults that will frequently hit large applications as we approach exascale supercomputing. Changes in the structure of weather and climate models that would allow them to be resilient against hardware faults are hardly discussed in the model development community. We present an approach to secure the dynamical core of weather and climate models against hardware faults using a backup system that stores coarse resolution copies of prognostic variables. Frequent checks of the model fields on the backup grid allow the detection of severe hardware faults, and prognostic variables that are changed by hardware faults on the model grid can be restored from the backup grid to continue model simulations with no significant delay. To justify the approach, we perform simulations with a C-grid shallow water model in the presence of frequent hardware faults. As long as the backup system is used, simulations do not crash and a high level of model quality can be maintained. The overhead due to the backup system is reasonable and additional storage requirements are small. Runtime is increased by only 13% for the shallow water model.

ELM - A SIMPLE TOOL FOR THERMAL-HYDRAULIC ANALYSIS OF SOLID-CORE NUCLEAR ROCKET FUEL ELEMENTS

NASA Technical Reports Server (NTRS)

Walton, J. T.

1994-01-01

ELM is a simple computational tool for modeling the steady-state thermal-hydraulics of propellant flow through fuel element coolant channels in nuclear thermal rockets. Written for the nuclear propulsion project of the Space Exploration Initiative, ELM evaluates the various heat transfer coefficient and friction factor correlations available for turbulent pipe flow with heat addition. In the past, these correlations were found in different reactor analysis codes, but now comparisons are possible within one program. The logic of ELM is based on the one-dimensional conservation of energy in combination with Newton's Law of Cooling to determine the bulk flow temperature and the wall temperature across a control volume. Since the control volume is an incremental length of tube, the corresponding pressure drop is determined by application of the Law of Conservation of Momentum. The size, speed, and accuracy of ELM make it a simple tool for use in fuel element parametric studies. ELM is a machine independent program written in FORTRAN 77. It has been successfully compiled on an IBM PC compatible running MS-DOS using Lahey FORTRAN 77, a DEC VAX series computer running VMS, and a Sun4 series computer running SunOS UNIX. ELM requires 565K of RAM under SunOS 4.1, 360K of RAM under VMS 5.4, and 406K of RAM under MS-DOS. Because this program is machine independent, no executable is provided on the distribution media. The standard distribution medium for ELM is one 5.25 inch 360K MS-DOS format diskette. ELM was developed in 1991. DEC, VAX, and VMS are trademarks of Digital Equipment Corporation. Sun4 and SunOS are trademarks of Sun Microsystems, Inc. IBM PC is a registered trademark of International Business Machines. MS-DOS is a registered trademark of Microsoft Corporation.

The near-source impacts of diesel backup generators in urban environments

NASA Astrophysics Data System (ADS)

Tong, Zheming; Zhang, K. Max

2015-05-01

Distributed power generation, located close to consumers, plays an important role in the current and future power systems. However, its near-source impacts in complex urban environments are not well understood. In this paper, we focused on diesel backup generators that participate in demand response (DR) programs. We first improved the micro-environmental air quality simulations by employing a meteorology processor, AERMET, to generate site-specific boundary layer parameters for the Large Eddy Simulation (LES) modeling. The modeling structure was then incorporated into the CTAG model to evaluate the environmental impacts of diesel backup generators in near-source microenvironments. We found that the presence of either tall upwind or downwind building can deteriorate the air quality in the near-stack street canyons, largely due to the recirculation zones generated by the tall buildings, reducing the near-stack dispersion. Decreasing exhaust momentum ratio (stack exit velocity/ambient wind velocity) draws more exhaust into the recirculation zone, and reduces the effective stack height, which results in elevated near-ground concentrations inside downwind street canyons. The near-ground PM2.5 concentration for the worst scenarios could well exceed 100 μg m-3, posing potential health risk to people living and working nearby. In general, older diesel backup generators (i.e., Tier 1, 2 or older) without the up-to-date emission control may significantly increase the pollutant concentration in the near-source street canyons if participating in DR programs. Even generators that comply with Tier-4 standards could lead to PM hotspots if their stacks are next to tall buildings. Our study implies that the siting of diesel backup generators stacks should consider not only the interactions of fresh air intake and exhaust outlet for the building housing the backup generators, but also the dispersion of exhaust plumes in the surrounding environment.

Lead isotope data bank; 2,624 samples and analyses cited

USGS Publications Warehouse

Doe, Bruce R.

1976-01-01

The Lead Isotope Data Bank (LIDB) was initiated to facilitate plotting data. Therefore, the Bank reflects data most often used in plotting rather than comprises a comprehensive tabulation of lead isotope data. Up until now, plotting was done using card decks processed by computer with tapes plotted by a Gerber plotter and more recently a CRT using a batch mode. Lack of a uniform format for sample identification was not a great impediment. With increase in the size of the bank, hand sorting is becoming prohibitive and ·plans are underway to put the bank into a uniform format on DISK with a card backup so that it may be accessed by use of IRIS on the DECK 10 computer at the U.S.G.S. facility in Denver. Plots will be constructed on a CRT. Entry of the bank into the IRIS accessing program is scheduled for completion in FY 1976

POLCAL - POLARIMETRIC RADAR CALIBRATION

NASA Technical Reports Server (NTRS)

Vanzyl, J.

1994-01-01

Calibration of polarimetric radar systems is a field of research in which great progress has been made over the last few years. POLCAL (Polarimetric Radar Calibration) is a software tool intended to assist in the calibration of Synthetic Aperture Radar (SAR) systems. In particular, POLCAL calibrates Stokes matrix format data produced as the standard product by the NASA/Jet Propulsion Laboratory (JPL) airborne imaging synthetic aperture radar (AIRSAR). POLCAL was designed to be used in conjunction with data collected by the NASA/JPL AIRSAR system. AIRSAR is a multifrequency (6 cm, 24 cm, and 68 cm wavelength), fully polarimetric SAR system which produces 12 x 12 km imagery at 10 m resolution. AIRSTAR was designed as a testbed for NASA's Spaceborne Imaging Radar program. While the images produced after 1991 are thought to be calibrated (phase calibrated, cross-talk removed, channel imbalance removed, and absolutely calibrated), POLCAL can and should still be used to check the accuracy of the calibration and to correct it if necessary. Version 4.0 of POLCAL is an upgrade of POLCAL version 2.0 released to AIRSAR investigators in June, 1990. New options in version 4.0 include automatic absolute calibration of 89/90 data, distributed target analysis, calibration of nearby scenes with calibration parameters from a scene with corner reflectors, altitude or roll angle corrections, and calibration of errors introduced by known topography. Many sources of error can lead to false conclusions about the nature of scatterers on the surface. Errors in the phase relationship between polarization channels result in incorrect synthesis of polarization states. Cross-talk, caused by imperfections in the radar antenna itself, can also lead to error. POLCAL reduces cross-talk and corrects phase calibration without the use of ground calibration equipment. Removing the antenna patterns during SAR processing also forms a very important part of the calibration of SAR data. Errors in the processing altitude or in the aircraft roll angle are possible causes of error in computing the antenna patterns inside the processor. POLCAL uses an altitude error correction algorithm to correctly remove the antenna pattern from the SAR images. POLCAL also uses a topographic calibration algorithm to reduce calibration errors resulting from ground topography. By utilizing the backscatter measurements from either the corner reflectors or a well-known distributed target, POLCAL can correct the residual amplitude offsets in the various polarization channels and correct for the absolute gain of the radar system. POLCAL also gives the user the option of calibrating a scene using the calibration data from a nearby site. This allows precise calibration of all the scenes acquired on a flight line where corner reflectors were present. Construction and positioning of corner reflectors is covered extensively in the program documentation. In an effort to keep the POLCAL code as transportable as possible, the authors eliminated all interactions with a graphics display system. For this reason, it is assumed that users will have their own software for doing the following: (1) synthesize an image using HH or VV polarization, (2) display the synthesized image on any display device, and (3) read the pixel locations of the corner reflectors from the image. The only inputs used by the software (in addition to the input Stokes matrix data file) is a small data file with the corner reflector information. POLCAL is written in FORTRAN 77 for use on Sun series computers running SunOS and DEC VAX computers running VMS. It requires 4Mb of RAM under SunOS and 3.7Mb of RAM under VMS for execution. The standard distribution medium for POLCAL is a .25 inch streaming magnetic tape cartridge in UNIX tar format. It is also available on a 9-track 1600 BPI magnetic tape in DEC VAX FILES-11 format or on a TK50 tape cartridge in DEC VAX FILES-11 format. Other distribution media may be available upon request. Documentation is included in the price of the program. POLCAL 4.0 was released in 1992 and is a copyrighted work with all copyright vested in NASA.

Clinical experiences utilizing wireless remote control and an ASP model backup archive for a disaster recovery event

NASA Astrophysics Data System (ADS)

Liu, Brent J.; Documet, Luis; Documet, Jorge; Huang, H. K.; Muldoon, Jean

2004-04-01

An Application Service Provider (ASP) archive model for disaster recovery for Saint John"s Health Center (SJHC) clinical PACS data has been implemented using a Fault-Tolerant Archive Server at the Image Processing and Informatics Laboratory, Marina del Rey, CA (IPIL) since mid-2002. The purpose of this paper is to provide clinical experiences with the implementation of an ASP model backup archive in conjunction with handheld wireless technologies for a particular disaster recovery scenario, an earthquake, in which the local PACS archive and the hospital are destroyed and the patients are moved from one hospital to another. The three sites involved are: (1) SJHC, the simulated disaster site; (2) IPIL, the ASP backup archive site; and (3) University of California, Los Angeles Medical Center (UCLA), the relocated patient site. An ASP backup archive has been established at IPIL to receive clinical PACS images daily using a T1 line from SJHC for backup and disaster recovery storage. Procedures were established to test the network connectivity and data integrity on a regular basis. In a given disaster scenario where the local PACS archive has been destroyed and the patients need to be moved to a second hospital, a wireless handheld device such as a Personal Digital Assistant (PDA) can be utilized to route images to the second hospital site with a PACS and reviewed by radiologists. To simulate this disaster scenario, a wireless network was implemented within the clinical environment in all three sites: SJHC, IPIL, and UCLA. Upon executing the disaster scenario, the SJHC PACS archive server simulates a downtime disaster event. Using the PDA, the radiologist at UCLA can query the ASP backup archive server at IPIL for PACS images and route them directly to UCLA. Implementation experiences integrating this solution within the three clinical environments as well as the wireless performance are discussed. A clinical downtime disaster scenario was implemented and successfully tested. Radiologists were able to successfully query PACS images utilizing a wireless handheld device from the ASP backup archive at IPIL and route the PACS images directly to a second clinical site at UCLA where they and the patients are located at that time. In a disaster scenario, using a wireless device, radiologists at the disaster health care center can route PACS data from an ASP backup archive server to be reviewed in a live clinical PACS environment at a secondary site. This solution allows Radiologists to use a wireless handheld device to control the image workflow and to review PACS images during a major disaster event where patients must be moved to a secondary site.

CARES/PC - CERAMICS ANALYSIS AND RELIABILITY EVALUATION OF STRUCTURES

NASA Technical Reports Server (NTRS)

Szatmary, S. A.

1994-01-01

The beneficial properties of structural ceramics include their high-temperature strength, light weight, hardness, and corrosion and oxidation resistance. For advanced heat engines, ceramics have demonstrated functional abilities at temperatures well beyond the operational limits of metals. This is offset by the fact that ceramic materials tend to be brittle. When a load is applied, their lack of significant plastic deformation causes the material to crack at microscopic flaws, destroying the component. CARES/PC performs statistical analysis of data obtained from the fracture of simple, uniaxial tensile or flexural specimens and estimates the Weibull and Batdorf material parameters from this data. CARES/PC is a subset of the program CARES (COSMIC program number LEW-15168) which calculates the fast-fracture reliability or failure probability of ceramic components utilizing the Batdorf and Weibull models to describe the effects of multi-axial stress states on material strength. CARES additionally requires that the ceramic structure be modeled by a finite element program such as MSC/NASTRAN or ANSYS. The more limited CARES/PC does not perform fast-fracture reliability estimation of components. CARES/PC estimates ceramic material properties from uniaxial tensile or from three- and four-point bend bar data. In general, the parameters are obtained from the fracture stresses of many specimens (30 or more are recommended) whose geometry and loading configurations are held constant. Parameter estimation can be performed for single or multiple failure modes by using the least-squares analysis or the maximum likelihood method. Kolmogorov-Smirnov and Anderson-Darling goodness-of-fit tests measure the accuracy of the hypothesis that the fracture data comes from a population with a distribution specified by the estimated Weibull parameters. Ninety-percent confidence intervals on the Weibull parameters and the unbiased value of the shape parameter for complete samples are provided when the maximum likelihood technique is used. CARES/PC is written and compiled with the Microsoft FORTRAN v5.0 compiler using the VAX FORTRAN extensions and dynamic array allocation supported by this compiler for the IBM/MS-DOS or OS/2 operating systems. The dynamic array allocation routines allow the user to match the number of fracture sets and test specimens to the memory available. Machine requirements include IBM PC compatibles with optional math coprocessor. Program output is designed to fit 80-column format printers. Executables for both DOS and OS/2 are provided. CARES/PC is distributed on one 5.25 inch 360K MS-DOS format diskette in compressed format. The expansion tool PKUNZIP.EXE is supplied on the diskette. CARES/PC was developed in 1990. IBM PC and OS/2 are trademarks of International Business Machines. MS-DOS and MS OS/2 are trademarks of Microsoft Corporation. VAX is a trademark of Digital Equipment Corporation.

76 FR 20503 - Airworthiness Directives; Empresa Brasileira de Aeronautica S.A. (EMBRAER) Model ERJ 170 and ERJ...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-04-13

... of the related balance washer causing a possible ram air turbine (RAT) imbalance event, which may... in loss of power to airplane flight controls hydraulic back-up system. * * * * * Loss of power to the hydraulic back-up system for airplane flight controls could reduce the ability of the flightcrew to maintain...

PC-403: Pioneer Venus multiprobe spacecraft mission operational characteristics document, volume 3

NASA Technical Reports Server (NTRS)

Barker, F. C.

1978-01-01

The Pioneer Venus spacecraft primary and backup operational modes and operational limitations for maneuvers, roll references transfer, attitude determination, spacecraft power discipline and spacecraft thermal discipline, are described. The functions and operations of the large and small probes, as well detailed performance in the normal operating modes and backup modes are presented.

Recommended high-tank temperatures for maintenance of high-tank backup support, Revision 3

DOE Office of Scientific and Technical Information (OSTI.GOV)

Greager, O.H.

1964-05-20

Purpose of this note is to recommend revised curves for the high-tank temperature required to maintain adequate high-tank backup support at the six small reactors. Compliance with the conditions shown on these curves will ensure adequate high-tank flow rates following the simultaneous loss of electric and steam power.

Towards Efficient Scientific Data Management Using Cloud Storage

NASA Technical Reports Server (NTRS)

He, Qiming

2013-01-01

A software prototype allows users to backup and restore data to/from both public and private cloud storage such as Amazon's S3 and NASA's Nebula. Unlike other off-the-shelf tools, this software ensures user data security in the cloud (through encryption), and minimizes users operating costs by using space- and bandwidth-efficient compression and incremental backup. Parallel data processing utilities have also been developed by using massively scalable cloud computing in conjunction with cloud storage. One of the innovations in this software is using modified open source components to work with a private cloud like NASA Nebula. Another innovation is porting the complex backup to- cloud software to embedded Linux, running on the home networking devices, in order to benefit more users.

Crew-Aided Autonomous Navigation Project

NASA Technical Reports Server (NTRS)

Holt, Greg

2015-01-01

Manual capability to perform star/planet-limb sightings provides a cheap, simple, and robust backup navigation source for exploration missions independent from the ground. Sextant sightings from spacecraft were first exercised in Gemini and flew as the loss-of-communications backup for all Apollo missions. This study seeks to procure and characterize error sources of navigation-grade sextants for feasibility of taking star and planetary limb sightings from inside a spacecraft. A series of similar studies was performed in the early/mid-1960s in preparation for Apollo missions, and one goal of this study is to modernize and update those findings. This technique has the potential to deliver significant risk mitigation, validation, and backup to more complex low-TRL automated systems under development involving cameras.

CREW TRAINING - STS-33/51L (ZERO-G)

NASA Image and Video Library

1985-11-20

S85-44835 (20 Nov. 1985) --- This flying human chain represents prime and backup payload specialists for two upcoming STS missions. The group, representing trainees for STS-61C later this year and STS-51L early next year, shared some 40 parabolas in NASA?s KSC-135, ?Zero-G? aircraft on Nov. 20. Left to right are Gerard Magilton, RCA backup payload specialist for STS-61C; Sharon Christa McAuliffe, payload specialist/teacher citizen observer for STS-51L; U.S. Rep. Bill Nelson (D., Florida), scheduled for 61-C; Barbara R. Morgan, backup to McAuliffe; and Robert J. Cenker, RCA payload specialist for 61-C. The photo was taken by Keith Meyers, New York Times. Photo credit: NASA

CREW TRAINING - STS-33/51-L (Zero-G)

NASA Image and Video Library

1985-11-20

S85-44834 (20 Nov. 1985) --- This flying human chain represents prime and backup payload specialists for two upcoming STS missions. The group, representing trainees for STS-61C later this year and STS-51L early next year, shared some 40 parabolas in NASA?s KC-135, ?Zero-G? aircraft on Nov. 20, 1985. Left to right are Gerard Magilton, RCA backup payload specialist for STS-61C; Sharon Christa McAuliffe, payload specialist/teacher citizen observer for STS-51L; U.S. Representative Bill Nelson (D., Florida), scheduled for 61C; Barbara R. Morgan, backup to McAuliffe; and Robert J. Cenker, RCA payload specialist for 61C. The photo was taken by Otis Imboden. Photo credit: NASA

Space lab system analysis

NASA Technical Reports Server (NTRS)

Rives, T. B.; Ingels, F. M.

1988-01-01

An analysis of the Automated Booster Assembly Checkout System (ABACS) has been conducted. A computer simulation of the ETHERNET LAN has been written. The simulation allows one to investigate different structures of the ABACS system. The simulation code is in PASCAL and is VAX compatible.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Not Available

This manual is a guide to use the file protection mechanisms available on the Martin Marietta Energy Systems, Inc. Scientific and Technical Computing (STC) System VAXes. User identification codes (UICs) and general identifiers are discussed as a basis for understanding UIC-based and access control list (ACL) protection. 5 figs.

76 FR 42577 - Magnuson-Stevens Act Provisions; Fisheries of the Northeastern United States; Northeast...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-07-19

... comply with trip limits. However, the current system does not accurately account for the fish landed for... confirm the receipt of the TSH report via a back-up system specified by the DSM service provider. The... via a back-up system, after a time determined by the DSM provider, to confirm the receipt of the TSH...

Fuel Cell Backup Power Geographical Visualization Map (Fact Sheet)

DOE Office of Scientific and Technical Information (OSTI.GOV)

Not Available

2012-12-01

This NREL Hydrogen and Fuel Cell Technical Highlight describes a time-lapse geographical visualization map of early market use of fuel cells for telecommunications backup power. The map synthesizes data being analyzed by NREL's Technology Validation team for the U.S. Department of Energy (DOE) Fuel Cell Technologies Program with DOE's publicly available annual summaries of electric disturbance events.

95. VIEW OF SOUTHWEST CORNER OF LANDLINE INSTRUMENTATION ROOM (106), ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

95. VIEW OF SOUTHWEST CORNER OF LANDLINE INSTRUMENTATION ROOM (106), LSB (BLDG. 770). BATTERY RACK FOR BACKUP BOOSTER POWER ON LEFT; BATTERY RACK FOR BACKUP AEROSPACE GROUND EQUIPMENT (AGE) POWER ON RIGHT. BATTERY CHARGER IS RIGHT OF BATTERY RACKS. - Vandenberg Air Force Base, Space Launch Complex 3, Launch Pad 3 West, Napa & Alden Roads, Lompoc, Santa Barbara County, CA

The Fermilab Accelerator control system

NASA Astrophysics Data System (ADS)

Bogert, Dixon

1986-06-01

With the advent of the Tevatron, considerable upgrades have been made to the controls of all the Fermilab Accelerators. The current system is based on making as large an amount of data as possible available to many operators or end-users. Specifically there are about 100 000 separate readings, settings, and status and control registers in the various machines, all of which can be accessed by seventeen consoles, some in the Main Control Room and others distributed throughout the complex. A "Host" computer network of approximately eighteen PDP-11/34's, seven PDP-11/44's, and three VAX-11/785's supports a distributed data acquisition system including Lockheed MAC-16's left from the original Main Ring and Booster instrumentation and upwards of 1000 Z80, Z8002, and M68000 microprocessors in dozens of configurations. Interaction of the various parts of the system is via a central data base stored on the disk of one of the VAXes. The primary computer-hardware communication is via CAMAC for the new Tevatron and Antiproton Source; certain subsystems, among them vacuum, refrigeration, and quench protection, reside in the distributed microprocessors and communicate via GAS, an in-house protocol. An important hardware feature is an accurate clock system making a large number of encoded "events" in the accelerator supercycle available for both hardware modules and computers. System software features include the ability to save the current state of the machine or any subsystem and later restore it or compare it with the state at another time, a general logging facility to keep track of specific variables over long periods of time, detection of "exception conditions" and the posting of alarms, and a central filesharing capability in which files on VAX disks are available for access by any of the "Host" processors.

TOOLKIT, Version 2. 0

DOE Office of Scientific and Technical Information (OSTI.GOV)

Schroeder, E.; Bagot, B.; McNeill, R.L.

1990-05-09

The purpose of this User's Guide is to show by example many of the features of Toolkit II. Some examples will be copies of screens as they appear while running the Toolkit. Other examples will show what the user should enter in various situations; in these instances, what the computer asserts will be in boldface and what the user responds will be in regular type. The User's Guide is divided into four sections. The first section, FOCUS Databases'', will give a broad overview of the Focus administrative databases that are available on the VAX; easy-to-use reports are available for mostmore » of them in the Toolkit. The second section, Getting Started'', will cover the steps necessary to log onto the Computer Center VAX cluster and how to start Focus and the Toolkit. The third section, Using the Toolkit'', will discuss some of the features in the Toolkit -- the available reports and how to access them, as well as some utilities. The fourth section, Helpful Hints'', will cover some useful facts about the VAX and Focus as well as some of the more common problems that can occur. The Toolkit is not set in concrete but is continually being revised and improved. If you have any opinions as to changes that you would like to see made to the Toolkit or new features that you would like included, please let us know. Since we do try to respond to the needs of the user and make periodic improvement to the Toolkit, this User's Guide may not correspond exactly to what is available in the computer. In general, changes are made to provide new options or features; rarely is an existing feature deleted.« less

OASIS - ORBIT ANALYSIS AND SIMULATION SOFTWARE

NASA Technical Reports Server (NTRS)

Wu, S. C.

1994-01-01

The Orbit Analysis and Simulation Software, OASIS, is a software system developed for covariance and simulation analyses of problems involving earth satellites, especially the Global Positioning System (GPS). It provides a flexible, versatile and efficient accuracy analysis tool for earth satellite navigation and GPS-based geodetic studies. To make future modifications and enhancements easy, the system is modular, with five major modules: PATH/VARY, REGRES, PMOD, FILTER/SMOOTHER, and OUTPUT PROCESSOR. PATH/VARY generates satellite trajectories. Among the factors taken into consideration are: 1) the gravitational effects of the planets, moon and sun; 2) space vehicle orientation and shapes; 3) solar pressure; 4) solar radiation reflected from the surface of the earth; 5) atmospheric drag; and 6) space vehicle gas leaks. The REGRES module reads the user's input, then determines if a measurement should be made based on geometry and time. PMOD modifies a previously generated REGRES file to facilitate various analysis needs. FILTER/SMOOTHER is especially suited to a multi-satellite precise orbit determination and geodetic-type problems. It can be used for any situation where parameters are simultaneously estimated from measurements and a priori information. Examples of nonspacecraft areas of potential application might be Very Long Baseline Interferometry (VLBI) geodesy and radio source catalogue studies. OUTPUT PROCESSOR translates covariance analysis results generated by FILTER/SMOOTHER into user-desired easy-to-read quantities, performs mapping of orbit covariances and simulated solutions, transforms results into different coordinate systems, and computes post-fit residuals. The OASIS program was developed in 1986. It is designed to be implemented on a DEC VAX 11/780 computer using VAX VMS 3.7 or higher. It can also be implemented on a Micro VAX II provided sufficient disk space is available.

Elevated levels of maternal anti-tetanus toxin antibodies do not suppress the immune response to a Haemophilus influenzae type b polyribosylphosphate-tetanus toxoid conjugate vaccine.

PubMed Central

Panpitpat, C.; Thisyakorn, U.; Chotpitayasunondh, T.; Fürer, E.; Que, J. U.; Hasler, T.; Cryz, S. J.

2000-01-01

Reported are the effects of elevated levels of anti-tetanus antibodies on the safety and immune response to a Haemophilus influenzae type b polyribosylphosphate (PRP)-tetanus toxoid conjugate (PRP-T) vaccine. A group of Thai infants (n = 177) born to women immunized against tetanus during pregnancy were vaccinated with either a combined diphtheria-tetanus-pertussis (DTP) PRP-T vaccine or DTP and a PRP-conjugate vaccine using Neisseria meningitidis group B outer-membrane proteins as a carrier (PedVax HIB). Although most infants possessed high titres (> 1 IU/ml) of anti-tetanus antibodies, the DTP-PRP-T combined vaccine engendered an excellent antibody response to all vaccine components. In both vaccine groups > 98% of infants attained anti-PRP antibody titres > or = 0.15 microgram/ml. The geometric mean anti-PRP antibody titres were 5.41 micrograms/ml and 2.1 micrograms/ml for infants immunized with three doses of PRP-T versus two doses of PedVax HIB vaccines, respectively (P < 0.005). Similarly, the proportion of infants who achieved titres > or = 1 microgram/ml was higher in the PRP-T group (87.8%) than in the group immunized with PedVax HIB (74.2%) (P = 0.036). A subgroup analysis showed that there was no significant difference in the anti-PRP antibody response for infants exhibiting either < 1 IU of anti-tetanus antibody per millilitre or > or = 1 IU/ml at baseline. These finding indicate that pre-existing anti-carrier antibody does not diminish the immune response to the PRP moiety. All infants possessed protective levels of anti-D and anti-T antibody levels after immunization. PMID:10812736

DOE Office of Scientific and Technical Information (OSTI.GOV)

Senova, Suhan; Service de Neurochirurgie, Centre Hospitalier Universitaire; Inserm, U955, Equipe 14, Université Paris Est, Faculté de médecine, Créteil

Purpose: To analyze the relationship between dosimetric characteristics and symptoms related to trigeminal neuropathy (TN) observed after radiosurgery (RS) for vestibular schwannomas (VS); to propose guidelines to optimize planification in VS RS regarding TN preservation; and to detail the mechanism of TN impairment after VS RS. Methods and Materials: One hundred seventy-nine patients treated between 2011 and 2013 for VS RS and without trigeminal impairment before RS were included in a retrospective study. Univariate and multivariate analyses were performed to determine predictors of TN among characteristics of the patients, the dosimetry, and the VS. Results: There were 20 Koos grade 1,more » 99 grade 2, 57 grade 3, and 3 grade 4. Fourteen patients (7.8%) presented a transitory or permanent TN. Between the patients with and without TN after VS RS, there was no significant difference regarding dosimetry or VS volume itself. Significant differences (univariate analysis P<.05, Mann-Whitney test) were found for parameters related to the cisternal portion of the trigeminal nerve: total integrated dose, maximum dose, mean dose, volume of the Vth nerve (Vol{sub v}), and volume of the Vth nerve receiving at least 11 Gy (Vol{sub Vcist>11Gy}), but also for maximal dose to the Vth nerve nucleus and intra-axial portion (Dose max{sub Vax}). After multivariate analysis, the best model predicting TN included Vol{sub Vcist>11Gy} (P=.0045), Dose max{sub Vax} (P=.0006), and Vol{sub v} (P=.0058). The negative predictive value of this model was 97%. Conclusions: The parameters Vol{sub Vcist>11Gy}, Dose max{sub Vax}, and Vol{sub v} should be checked when designing dosimetry for VS RS.« less

Induction of protective immunity against Eimeria tenella, Eimeria necatrix, Eimeria maxima and Eimeria acervulina infections using multivalent epitope DNA vaccines.

PubMed

Song, Xiaokai; Ren, Zhe; Yan, Ruofeng; Xu, Lixin; Li, Xiangrui

2015-06-04

Avian coccidiosis is mostly caused by mixed infection of several Eimeria species under natural conditions and immunity to avian coccidiosis is largely dependent on T-cell immune response. In this study, 14 T-cell epitope fragments from eight antigens of Eimeria tenella (E. tenella), Eimeria necatrix (E. necatrix), Eimeria maxima (E. maxima) and Eimeria acervulina (E. acervulina) were ligated with pVAX1 producing 14 monovalent DNA vaccines, respectively. Protective immunity of the monovalent DNA vaccines was assessed by in vivo challenge experiments and then four most protective fragments of each species were chosen to construct multivalent epitope DNA vaccines with or without chicken IL-2 as genetic adjuvant. Protective efficacies of the epitope DNA vaccines on chickens against E. tenella, E. necatrix, E. maxima and E. acervulina were evaluated. The results showed that the constructed multivalent epitope DNA vaccines significantly increased body weight gain, alleviated enteric lesions and reduced oocyst output of the infected birds. Especially, the multivalent epitope DNA vaccines of pVAX1-NA4-1-TA4-1-LDH-2-EMCDPK-1 and pVAX1-NA4-1-TA4-1-LDH-2-EMCDPK-1-IL-2 not only significantly increased body weight gain, alleviated enteric lesions and reduced oocyst output of the infected birds, but also resulted in anti-coccidial index (ACI) more than 170 against E. tenella, E. necatrix, E. maxima and E. acervulina, which indicated they could induce protective immunity against E. tenella, E. necatrix, E. maxima and E. acervulina. Our findings suggest the constructed multivalent epitope DNA vaccines are the potential candidate multivalent vaccines against mixed infection of Eimeria. Copyright © 2015 Elsevier Ltd. All rights reserved.

Fail-over file transfer process

NASA Technical Reports Server (NTRS)

Semancik, Susan K. (Inventor); Conger, Annette M. (Inventor)

2005-01-01

The present invention provides a fail-over file transfer process to handle data file transfer when the transfer is unsuccessful in order to avoid unnecessary network congestion and enhance reliability in an automated data file transfer system. If a file cannot be delivered after attempting to send the file to a receiver up to a preset number of times, and the receiver has indicated the availability of other backup receiving locations, then the file delivery is automatically attempted to one of the backup receiving locations up to the preset number of times. Failure of the file transfer to one of the backup receiving locations results in a failure notification being sent to the receiver, and the receiver may retrieve the file from the location indicated in the failure notification when ready.

User's guide to HYPOINVERSE-2000, a Fortran program to solve for earthquake locations and magnitudes

USGS Publications Warehouse

Klein, Fred W.

2002-01-01

Hypoinverse is a computer program that processes files of seismic station data for an earthquake (like p wave arrival times and seismogram amplitudes and durations) into earthquake locations and magnitudes. It is one of a long line of similar USGS programs including HYPOLAYR (Eaton, 1969), HYPO71 (Lee and Lahr, 1972), and HYPOELLIPSE (Lahr, 1980). If you are new to Hypoinverse, you may want to start by glancing at the section “SOME SIMPLE COMMAND SEQUENCES” to get a feel of some simpler sessions. This document is essentially an advanced user’s guide, and reading it sequentially will probably plow the reader into more detail than he/she needs. Every user must have a crust model, station list and phase data input files, and glancing at these sections is a good place to begin. The program has many options because it has grown over the years to meet the needs of one the largest seismic networks in the world, but small networks with just a few stations do use the program and can ignore most of the options and commands. History and availability. Hypoinverse was originally written for the Eclipse minicomputer in 1978 (Klein, 1978). A revised version for VAX and Pro-350 computers (Klein, 1985) was later expanded to include multiple crustal models and other capabilities (Klein, 1989). This current report documents the expanded Y2000 version and it supercedes the earlier documents. It serves as a detailed user's guide to the current version running on unix and VAX-alpha computers, and to the version supplied with the Earthworm earthquake digitizing system. Fortran-77 source code (Sun and VAX compatible) and copies of this documentation is available via anonymous ftp from computers in Menlo Park. At present, the computer is swave.wr.usgs.gov and the directory is /ftp/pub/outgoing/klein/hyp2000. If you are running Hypoinverse on one of the Menlo Park EHZ or NCSN unix computers, the executable currently is ~klein/hyp2000/hyp2000. New features. The Y2000 version of Hypoinverse includes all of the previous capabilities, but adds Y2000 formats to those defined earlier. In most cases, the new formats add 2 digits to the year field to accommodate the century. Other fields are sometimes rearranged or expanded to accommodate a better field order. The Y2000 formats are invoked with the “200” command. When the Y2000 flag is turned on, all files are read and written in the new format and there is no mixing of format types in a single run. Some formats without a date field, like station files, have not changed. A separate program called 2000CONV has been written to convert old formats to new. Other new features, like expanded station names, calculating amplitude magnitudes from a variety of digital seismometers, station history files, interactive earthquake processing, and locations from CUSP (Caltech USGS Seismic Processing) binary files have been added. General features. Hypoinverse will locate any number of events in an input file, which can be in one of several different formats. Any or all of printout, summary or archive output may be produced. Hypoinverse is driven by user commands. The various commands define input and output files, set adjustable parameters, and solve for locations of a file of earthquake data using the parameters and files currently set. It is both interactive and "batch" in that commands may be executed either from the keyboard or from a file. You execute the commands in a file by typing @filename at the Hypoinverse prompt. Users may either supply parameters on the command line, or omit them and are prompted interactively. The current parameter values are displayed and may be taken as defaults by pressing just the RETURN key after the prompt. This makes the program very easy to use, providing you can remember the names of the commands. Combining commands with and without their required parameters into a command file permits a variety of customized procedures such as automatic input of crustal model and station data, but prompting for a different phase file each time. All commands are 3 letters long and most require one or more parameters or file names. If they appear on a line with a command, character strings such as filenames must be enclosed in apostrophes (single quotes). Appendix 1 gives this and other free-format rules for supplying parameters, which are parsed in Fortran. When several parameters are required following a command, any of them may be omitted by replacing them with null fields (see appendix 1). A null field leaves that parameter unchanged from its current or default value. When you start HYPOINVERSE, default values are in effect for all parameters except file names. Hypoinverse is a complicated program with many features and options. Many of these "advanced" or seldom used features are documented here, but are more detailed than a typical user needs to read about when first starting with the program. I have put some of this material in smaller type so that a first time user can concentrate on the more important information.

An easy-to-use diagnostic system development shell

NASA Technical Reports Server (NTRS)

Tsai, L. C.; Ross, J. B.; Han, C. Y.; Wee, W. G.

1987-01-01

The Diagnostic System Development Shell (DSDS), an expert system development shell for diagnostic systems, is described. The major objective of building the DSDS is to create a very easy to use and friendly environment for knowledge engineers and end-users. The DSDS is written in OPS5 and CommonLisp. It runs on a VAX/VMS system. A set of domain independent, generalized rules is built in the DSDS, so the users need not be concerned about building the rules. The facts are explicitly represented in a unified format. A powerful check facility which helps the user to check the errors in the created knowledge bases is provided. A judgement facility and other useful facilities are also available. A diagnostic system based on the DSDS system is question driven and can call or be called by other knowledge based systems written in OPS5 and CommonLisp. A prototype diagnostic system for diagnosing a Philips constant potential X-ray system has been built using the DSDS.

Ada and the rapid development lifecycle

NASA Technical Reports Server (NTRS)

Deforrest, Lloyd; Gref, Lynn

1991-01-01

JPL is under contract, through NASA, with the US Army to develop a state-of-the-art Command Center System for the US European Command (USEUCOM). The Command Center System will receive, process, and integrate force status information from various sources and provide this integrated information to staff officers and decision makers in a format designed to enhance user comprehension and utility. The system is based on distributed workstation class microcomputers, VAX- and SUN-based data servers, and interfaces to existing military mainframe systems and communication networks. JPL is developing the Command Center System utilizing an incremental delivery methodology called the Rapid Development Methodology with adherence to government and industry standards including the UNIX operating system, X Windows, OSF/Motif, and the Ada programming language. Through a combination of software engineering techniques specific to the Ada programming language and the Rapid Development Approach, JPL was able to deliver capability to the military user incrementally, with comparable quality and improved economies of projects developed under more traditional software intensive system implementation methodologies.

Astronomical image data compression by morphological skeleton transformation

NASA Astrophysics Data System (ADS)

Huang, L.; Bijaoui, A.

A compression method adapted for exact restoring of the detected objects and based on the morphological skeleton transformation is presented. The morphological skeleton provides a complete and compact description of an object and gives an efficient compression rate. The flexibility of choosing a structuring element adapted to different images and the simplicity of the implementation are considered to be advantages of the method. The experiment was carried out on three typical astronomical images. The first two images were obtained by digitizing a Palomar Schmidt photographic plate in a coma field with the PDS microdensitometer at Nice Observatory. The third image was obtained by CCD camera at the Pic du Midi Observatory. Each pixel was coded by 16 bits and stored at a computer system (VAX785) with STII format. Each image is characterized by 256 x 256 pixels. It is found that first image represents a stellar field, the second represents a set of galaxies in the Coma, and the third image contains an elliptical galaxy.

Definition and testing of the hydrologic component of the pilot land data system

NASA Technical Reports Server (NTRS)

Ragan, Robert M.; Sircar, Jayanta K.

1987-01-01

The specific aim was to develop within the Pilot Land Data System (PLDS) software design environment, an easily implementable and user friendly geometric correction procedure to readily enable the georeferencing of imagery data from the Advanced Very High Resolution Radiometer (AVHRR) onboard the NOAA series spacecraft. A software subsystem was developed within the guidelines set by the PLDS development environment utilizing NASA Goddard Space Flight Center (GSFC) Image Analysis Facility's (IAF's) Land Analysis Software (LAS) coding standards. The IAS current program development environment, the Transportable Applications Executive (TAE), operates under a VAX VMS operating system and was used as the user interface. A brief overview of the ICARUS algorithm that was implemented in the set of functions developed, is provided. The functional specifications decription is provided, and a list of the individual programs and directory names containing the source and executables installed in the IAF system are listed. A user guide is provided for the LAS system documentation format for the three functions developed.

Formation of stored heat by means of bled steam during times of load reduction and its use in peak load times

NASA Technical Reports Server (NTRS)

Bitterlich, E.

1977-01-01

Technical possibilities and economic advantages of integrating hot water storage systems into power plants fired with fossil fuels are discussed. The systems can be charged during times of load reduction and then used for back-up during peak load periods. Investment costs are higher for such systems than for gas turbine power plants fired with natural gas or light oil installed to meet peak load demand. However, by improving specific heat consumption by about 1,000 kcal/k ohm, which thus reduces the related costs, investment costs will be compensated for, so that power production costs will not increase.

nu/TPU -- A DEC TPU compatible editor for UNIX

NASA Astrophysics Data System (ADS)

Rehan, S. C.

nu/TPU is a fully programmable text processing utility compatible with the TPU system found on VMS systems. People used to using TPU or EDT on the former Starlink VAX/VMS service will find that nu/TPU is very similar to these editors.

Chemical application of diffusion quantum Monte Carlo

NASA Technical Reports Server (NTRS)

Reynolds, P. J.; Lester, W. A., Jr.

1984-01-01

The diffusion quantum Monte Carlo (QMC) method gives a stochastic solution to the Schroedinger equation. This approach is receiving increasing attention in chemical applications as a result of its high accuracy. However, reducing statistical uncertainty remains a priority because chemical effects are often obtained as small differences of large numbers. As an example, the single-triplet splitting of the energy of the methylene molecule CH sub 2 is given. The QMC algorithm was implemented on the CYBER 205, first as a direct transcription of the algorithm running on the VAX 11/780, and second by explicitly writing vector code for all loops longer than a crossover length C. The speed of the codes relative to one another as a function of C, and relative to the VAX, are discussed. The computational time dependence obtained versus the number of basis functions is discussed and this is compared with that obtained from traditional quantum chemistry codes and that obtained from traditional computer architectures.

Modeling and simulation of the data communication network at the ASRM Facility

NASA Technical Reports Server (NTRS)

Nirgudkar, R. P.; Moorhead, R. J.; Smith, W. D.

1994-01-01

This paper describes the modeling and simulation of the communication network for the NASA Advanced Solid Rocket Motor (ASRM) facility under construction at Yellow Creek near Luka, Mississippi. Manufacturing, testing, and operations at the ASRM site will be performed in different buildings scattered over an 1800 acre site. These buildings are interconnected through a local area network (LAN), which will contain one logical Fiber Distributed Data Interface (FDDI) ring acting as a backbone for the whole complex. The network contains approximately 700 multi-vendor workstations, 22 multi-vendor workcells, and 3 VAX clusters interconnected via Ethernet and FDDI. The different devices produce appreciably different traffic patterns, each pattern will be highly variable, and some patterns will be very bursty. Most traffic is between the VAX clusters and the other devices. Comdisco's Block Oriented Network Simulator (BONeS) has been used for network simulation. The two primary evaluation parameters used to judge the expected network performance are throughput and delay.

HIV vaccine trial willingness among injection and non-injection drug users in two urban centres, Barcelona and San Francisco.

PubMed

Etcheverry, M Florencia; Lum, Paula J; Evans, Jennifer L; Sanchez, Emilia; de Lazzari, Elisa; Mendez-Arancibia, Eva; Sierra, Ernesto; Gatell, José M; Page, Kimberly; Joseph, Joan

2011-02-24

Being able to recruit high-risk volunteers who are also willing to consider future participation in vaccine trials are critical features of vaccine preparedness studies. We described data from two cohorts of injection- and non-injection drug users in Barcelona, Spain [Red Cross centre] and in San Francisco, USA, [UFO-VAX study] at high risk of HIV/HCV infection to assess behaviour risk exposure and willingness to participate in future preventive HIV vaccine trials. We successfully identified drug-using populations that would be eligible for future HIV vaccine efficacy trials, based on reported levels of risk during screening and high levels of willingness to participate. In both groups, Red Cross and UFO-VAX respectively, HCV infection was highly prevalent at baseline (41% and 34%), HIV baseline seroprevalence was 4.2% and 1.5%, and high levels of willingness were seen (83% and 78%). Copyright © 2011 Elsevier Ltd. All rights reserved.

DET/MPS - The GSFC Energy Balance Programs

NASA Technical Reports Server (NTRS)

Jagielski, J. M.

1994-01-01

Direct Energy Transfer (DET) and MultiMission Spacecraft Modular Power System (MPS) computer programs perform mathematical modeling and simulation to aid in design and analysis of DET and MPS spacecraft power system performance in order to determine energy balance of subsystem. DET spacecraft power system feeds output of solar photovoltaic array and nickel cadmium batteries directly to spacecraft bus. MPS system, Standard Power Regulator Unit (SPRU) utilized to operate array at array's peak power point. DET and MPS perform minute-by-minute simulation of performance of power system. Results of simulation focus mainly on output of solar array and characteristics of batteries. Both packages limited in terms of orbital mechanics, they have sufficient capability to calculate data on eclipses and performance of arrays for circular or near-circular orbits. DET and MPS written in FORTRAN-77 with some VAX FORTRAN-type extensions. Both available in three versions: GSC-13374, for DEC VAX-series computers running VMS. GSC-13443, for UNIX-based computers. GSC-13444, for Apple Macintosh computers.

Space lab system analysis

NASA Technical Reports Server (NTRS)

Ingels, F. M.; Rives, T. B.

1987-01-01

An analytical analysis of the HOSC Generic Peripheral processing system was conducted. The results are summarized and they indicate that the maximum delay in performing screen change requests should be less than 2.5 sec., occurring for a slow VAX host to video screen I/O rate of 50 KBps. This delay is due to the average I/O rate from the video terminals to their host computer. Software structure of the main computers and the host computers will have greater impact on screen change or refresh response times. The HOSC data system model was updated by a newly coded PASCAL based simulation program which was installed on the HOSC VAX system. This model is described and documented. Suggestions are offered to fine tune the performance of the ETERNET interconnection network. Suggestions for using the Nutcracker by Excelan to trace itinerate packets which appear on the network from time to time were offered in discussions with the HOSC personnel. Several visits to the HOSC facility were to install and demonstrate the simulation model.

Moving BASISplus and TECHLIBplus from VAX/VMS to UNIX

DOE Office of Scientific and Technical Information (OSTI.GOV)

Dominiak, R.

1993-12-31

BASISplus is used at the Laboratory by the Technical Information Services (TIS) Department which is part of the Information and Publishing Division at ARGONNE. TIS operates the Argonne Information Management System (AIM). The AIM System consists of the ANL Libraries On-Line Database (a TECHLIBplus database), the Current Journals Database (IDI`s current contents search), the ANL Publications Tracking Database (a TECHLIBplus database), the Powder Diffraction File Database, and several CD-ROM databases available through a Novell network. The AIM System is available from the desktop of ANL staff through modem and network connections, as well as from the 10 science libraries atmore » ARGONNE. TIS has been a BASISplus and TECHLIBplus site from the start, and never migrated from BASIS K. The decision to migrate from the VAX/VMS platform to a UNIX platform. Migrating a product from one platform to another involves many decisions and considerations. These justifications, decisions, and considerations are explored in this report.« less

MAVIS III -- A Windows 95/NT Upgrade

DOE Office of Scientific and Technical Information (OSTI.GOV)

Hardwick, M.F.

1997-12-01

MAVIS (Modeling and Analysis of Explosive Valve Interactions) is a computer program that simulates operation of explosively actuated valve. MAVIS was originally written in Fortran in the mid 1970`s and was primarily run on the Sandia Vax computers in use through the early 1990`s. During the mid to late 1980`s MAVIS was upgraded to include the effects of plastic deformation and it became MAVIS II. When the Vax computers were retired, the Gas Transfer System (GTS) Development Department ported the code to the Macintosh and PC platforms, where it ran as a simple console application. All graphical output was lostmore » during these ports. GTS code developers recently completed an upgrade that provides a Windows 95/NT MAVIS application and restores all of the original graphical output. This upgrade is called MAVIS III version 1.0. This report serves both as a user`s manual for MAVIS III v 1.0 and as a general software development reference.« less

12. Detail of clutch and backup gasoline engine for powering ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

12. Detail of clutch and backup gasoline engine for powering Stoney gates. Clutch mechanism manufactured by Baldridge Machine Company, Detroit, Michigan, ca. 1910. Instrument to the left records volume of flow through headworks. View looking south towards Stoney gates. Photo by Jet Lowe, HAER, 1989. - Puget Sound Power & Light Company, White River Hydroelectric Project, 600 North River Avenue, Dieringer, Pierce County, WA

STS-47 backup payload specialists participate in JSC WETF bailout exercise

NASA Technical Reports Server (NTRS)

1992-01-01

STS-47 Endeavour, Orbiter Vehicle (OV) 105, backup payload specialists (left to right) Chiaki Naito-Mukai, Takao Doi, and Stan Koszelak, wearing launch and entry suits, sit on the poolside in JSC's Weightless Environment Training Facility (WETF) Bldg 29. These alternates are waiting to participate launch emergency egress (bailout) exercises. The training is conducted in the WETF pool to simulate a water landing.

The Design of Data Disaster Recovery of National Fundamental Geographic Information System

NASA Astrophysics Data System (ADS)

Zhai, Y.; Chen, J.; Liu, L.; Liu, J.

2014-04-01

With the development of information technology, data security of information system is facing more and more challenges. The geographic information of surveying and mapping is fundamental and strategic resource, which is applied in all areas of national economic, defence and social development. It is especially vital to national and social interests when such classified geographic information is directly concerning Chinese sovereignty. Several urgent problems that needs to be resolved for surveying and mapping are how to do well in mass data storage and backup, establishing and improving the disaster backup system especially after sudden natural calamity accident, and ensuring all sectors rapidly restored on information system will operate correctly. For overcoming various disaster risks, protect the security of data and reduce the impact of the disaster, it's no doubt the effective way is to analysis and research on the features of storage and management and security requirements, as well as to ensure that the design of data disaster recovery system suitable for the surveying and mapping. This article analyses the features of fundamental geographic information data and the requirements of storage management, three site disaster recovery system of DBMS plan based on the popular network, storage and backup, data replication and remote switch of application technologies. In LAN that synchronous replication between database management servers and the local storage of backup management systems, simultaneously, remote asynchronous data replication between local storage backup management systems and remote database management servers. The core of the system is resolving local disaster in the remote site, ensuring data security and business continuity of local site. This article focuses on the following points: background, the necessity of disaster recovery system, the analysis of the data achievements and data disaster recovery plan. Features of this program is to use a hardware-based data hot backup, and remote online disaster recovery support for Oracle database system. The achievement of this paper is in summarizing and analysing the common characteristics of disaster of surveying and mapping business system requirements, while based on the actual situation of the industry, designed the basic GIS disaster recovery solutions, and we also give the conclusions about key technologies of RTO and RPO.

Head-Elevated Patient Positioning Decreases Complications of Emergent Tracheal Intubation in the Ward and Intensive Care Unit.

PubMed

Khandelwal, Nita; Khorsand, Sarah; Mitchell, Steven H; Joffe, Aaron M

2016-04-01

Based on the data from elective surgical patients, positioning patients in a back-up head-elevated position for preoxygenation and tracheal intubation can improve patient safety. However, data specific to the emergent setting are lacking. We hypothesized that back-up head-elevated positioning would be associated with a decrease in complications related to tracheal intubation in the emergency room environment. This retrospective study was approved by the University of Washington Human Subjects Division (Seattle, WA). Eligible patients included all adults undergoing emergent tracheal intubation outside of the operating room by the anesthesiology-based airway service at 2 university-affiliated teaching hospitals. All intubations were through direct laryngoscopy for an indication other than full cardiopulmonary arrest. Patient characteristics and details of the intubation procedure were derived from the medical record. The primary study endpoint was the occurrence of a composite of any intubation-related complication: difficult intubation, hypoxemia, esophageal intubation, or pulmonary aspiration. Multivariable logistic regression was used to estimate the odds of the primary endpoint in the supine versus back-up head-elevated positions with adjustment for a priori-defined potential confounders (body mass index and a difficult intubation prediction score [Mallampati, obstructive sleep Apnea, Cervical mobility, mouth Opening, Coma, severe Hypoxemia, and intubation by a non-Anesthesiologist score]). Five hundred twenty-eight patients were analyzed. Overall, at least 1 intubation-related complication occurred in 76 of 336 (22.6%) patients managed in the supine position compared with 18 of 192 (9.3%) patients managed in the back-up head-elevated position. After adjusting for body mass index and the Mallampati, obstructive sleep Apnea, Cervical mobility, mouth Opening, Coma, severe Hypoxemia, and intubation by a non-Anesthesiologist score, the odds of encountering the primary endpoint during an emergency tracheal intubation in a back-up head-elevated position was 0.47 (95% confidence interval, 0.26-0.83; P = 0.01). Placing patients in a back-up head-elevated position, compared with supine position, during emergency tracheal intubation was associated with a reduced odds of airway-related complications.

Cost-Effectiveness Analysis of Nasal Continuous Positive Airway Pressure Versus Nasal High Flow Therapy as Primary Support for Infants Born Preterm.

PubMed

Huang, Li; Roberts, Calum T; Manley, Brett J; Owen, Louise S; Davis, Peter G; Dalziel, Kim M

2018-05-01

To compare the cost-effectiveness of 2 common "noninvasive" modes of respiratory support for infants born preterm. An economic evaluation was conducted as a component of a multicenter, randomized control trial from 2013 to 2015 enrolling infants born preterm at ≥28 weeks of gestation with respiratory distress, <24 hours old, who had not previously received endotracheal intubation and mechanical ventilation or surfactant. The economic evaluation was conducted from a healthcare sector perspective and the time horizon was from birth until death or first discharge. The cost-effectiveness of continuous positive airway pressure (CPAP) vs high-flow with "rescue" CPAP backup and high-flow without rescue CPAP backup (as sole primary support) were analyzed by using the hospital cost of inpatient stay in a tertiary center and the rates of endotracheal intubation and mechanical ventilation during admission. Hospital inpatient cost records for 435 infants enrolled in all Australian centers were obtained. With "rescue" CPAP backup, an incremental cost-effectiveness ratio was estimated of A$179 000 (US$123 000) per ventilation avoided if CPAP was used compared with high flow. Without rescue CPAP backup, cost per ventilation avoided was A$7000 (US$4800) if CPAP was used compared with high flow. As sole primary support, CPAP is highly likely to be cost-effective compared with high flow. Neonatal units choosing to use only one device should apply CPAP as primary respiratory support. Compared with high-flow with rescue CPAP backup, CPAP is unlikely to be cost-effective if willingness to pay per ventilation avoided is less than A$179 000 (US$123 000). Copyright © 2018 Elsevier Inc. All rights reserved.

The level of BMP4 signaling is critical for the regulation of distinct T-box gene expression domains and growth along the dorso-ventral axis of the optic cup

PubMed Central

Behesti, Hourinaz; Holt, James KL; Sowden, Jane C

2006-01-01

Background Polarised gene expression is thought to lead to the graded distribution of signaling molecules providing a patterning mechanism across the embryonic eye. Bone morphogenetic protein 4 (Bmp4) is expressed in the dorsal optic vesicle as it transforms into the optic cup. Bmp4 deletions in human and mouse result in failure of eye development, but little attempt has been made to investigate mammalian targets of BMP4 signaling. In chick, retroviral gene overexpression studies indicate that Bmp4 activates the dorsally expressed Tbx5 gene, which represses ventrally expressed cVax. It is not known whether the Tbx5 related genes, Tbx2 and Tbx3, are BMP4 targets in the mammalian retina and whether BMP4 acts at a distance from its site of expression. Although it is established that Drosophila Dpp (homologue of vertebrate Bmp4) acts as a morphogen, there is little evidence that BMP4 gradients are interpreted to create domains of BMP4 target gene expression in the mouse. Results Our data show that the level of BMP4 signaling is critical for the regulation of distinct Tbx2, Tbx3, Tbx5 and Vax2 gene expression domains along the dorso-ventral axis of the mouse optic cup. BMP4 signaling gradients were manipulated in whole mouse embryo cultures during optic cup development, by implantation of beads soaked in BMP4, or the BMP antagonist Noggin, to provide a local signaling source. Tbx2, Tbx3 and Tbx5, showed a differential response to alterations in the level of BMP4 along the entire dorso-ventral axis of the optic cup, suggesting that BMP4 acts across a distance. Increased levels of BMP4 caused expansion of Tbx2 and Tbx3, but not Tbx5, into the ventral retina and repression of the ventral marker Vax2. Conversely, Noggin abolished Tbx5 expression but only shifted Tbx2 expression dorsally. Increased levels of BMP4 signaling caused decreased proliferation, reduced retinal volume and altered the shape of the optic cup. Conclusion Our findings suggest the existence of a dorsal-high, ventral-low BMP4 signaling gradient across which distinct domains of Tbx2, Tbx3, Tbx5 and Vax2 transcription factor gene expression are set up. Furthermore we show that the correct level of BMP4 signaling is critical for normal growth of the mammalian embryonic eye. PMID:17173667

Multicast backup reprovisioning problem for Hamiltonian cycle-based protection on WDM networks

NASA Astrophysics Data System (ADS)

Din, Der-Rong; Huang, Jen-Shen

2014-03-01

As networks grow in size and complexity, the chance and the impact of failures increase dramatically. The pre-allocated backup resources cannot provide 100% protection guarantee when continuous failures occur in a network. In this paper, the multicast backup re-provisioning problem (MBRP) for Hamiltonian cycle (HC)-based protection on WDM networks for the link-failure case is studied. We focus on how to recover the protecting capabilities of Hamiltonian cycle against the subsequent link-failures on WDM networks for multicast transmissions, after recovering the multicast trees affected by the previous link-failure. Since this problem is a hard problem, an algorithm, which consists of several heuristics and a genetic algorithm (GA), is proposed to solve it. The simulation results of the proposed method are also given. Experimental results indicate that the proposed algorithm can solve this problem efficiently.

Dynamic segment shared protection for multicast traffic in meshed wavelength-division-multiplexing optical networks

NASA Astrophysics Data System (ADS)

Liao, Luhua; Li, Lemin; Wang, Sheng

2006-12-01

We investigate the protection approach for dynamic multicast traffic under shared risk link group (SRLG) constraints in meshed wavelength-division-multiplexing optical networks. We present a shared protection algorithm called dynamic segment shared protection for multicast traffic (DSSPM), which can dynamically adjust the link cost according to the current network state and can establish a primary light-tree as well as corresponding SRLG-disjoint backup segments for a dependable multicast connection. A backup segment can efficiently share the wavelength capacity of its working tree and the common resources of other backup segments based on SRLG-disjoint constraints. The simulation results show that DSSPM not only can protect the multicast sessions against a single-SRLG breakdown, but can make better use of the wavelength resources and also lower the network blocking probability.

Passive cooling system for liquid metal cooled nuclear reactors with backup coolant flow path

DOEpatents

Hunsbedt, Anstein; Boardman, Charles E.

1993-01-01

A liquid metal cooled nuclear fission reactor plant having a passive auxiliary safety cooling system for removing residual heat resulting from fuel decay during reactor shutdown, or heat produced during a mishap. This reactor plant is enhanced by a backup or secondary passive safety cooling system which augments the primary passive auxiliary cooling system when in operation, and replaces the primary system when rendered inoperable.

STS-45 backup Payload Specialist Chappell during water egress training at JSC

NASA Technical Reports Server (NTRS)

1991-01-01

STS-45 Atlantis, Orbiter Vehicle (OV) 104, backup Payload Specialist Charles R. Chappell, wearing launch and entry suit (LES), is suspended via his parachute harness above JSC's Weightless Environment Training Facility (WETF) Bldg 29 pool. Chappell will be dropped into the pool during the exercise which simulates a parachute landing into a body of water. SCUBA-equipped divers swimming in the pool will assist during the training.

STS-52 backup Payload Specialist Tryggvason during JSC bailout exercises

NASA Technical Reports Server (NTRS)

1992-01-01

STS-52 Columbia, Orbiter Vehicle (OV) 102, backup Payload Specialist Bjarni V. Tryggvason, wearing launch and entry suit (LES), checks his launch and entry helmet (LEH) fitting prior to participating in emergency egress (bailout) training exercises in JSC's Weightless Environment Training Facility (WETF) Bldg 29. The WETF's 25-ft deep pool will serve as the ocean during this water landing simulation. Tryggvason represents the Canadian Space Agency (CSA).

Current status of the UCSF second-generation PACS

NASA Astrophysics Data System (ADS)

Huang, H. K.; Arenson, Ronald L.; Wong, Albert W. K.; Bazzill, Todd M.; Lou, Shyhliang A.; Andriole, Katherine P.; Wang, Jun; Zhang, Jianguo; Wong, Stephen T. C.

1996-05-01

This paper describes the current status of the second generation PACS at UCSF commenced in October 1992. The UCSF PACS is designed in-house as a hospital-integrated PACS based on an open architecture concept using industrial standards including UNIX operating system, C programming language, X-Window user interface, TCP/IP communication protocol, DICOM 3.0 image standard and HL7 health data format. Other manufacturer's PACS components which conform with these standards can be easily integrated into the system. Relevant data from HIS and RIS is automatically incorporated into the PACS using HL7 data format and TCP/IP communication protocol. The UCSF system also takes advantage of state-of-the-art communication, storage, and software technologies in ATM, multiple storage media, automatic programming, multilevel processes for a better cost-performance system. The primary PACS network is the 155 Mbits/sec OC3 ATM with the Ethernet as the back-up. The UCSF PACS also connects Mt. Zion Hospital and San Francisco VA Medical Center in the San Francisco Bay area via an ATM wide area network with a T1 line as the back-up. Currently, five MR and five CT scanners from multiple sites, two computed radiography systems, two film digitizers, one US PACS module, the hospital HIS and the department RIS have been connected to the PACS network. The image data is managed by a mirrored database (Sybase). The PACS controller, with its 1.3 terabyte optical disk library, acquires 2.5 gigabytes digital data daily. Four 2K, five, 1,600-line multiple monitor display workstations are on line in neuroradiology, pediatric radiology and intensive care units for clinical use. In addition, the PACS supports over 100 Macintosh users in the department and selected hospital sites for both images and textual retrieval through a client/server mechanism. We are also developing a computation and visualization node in the PACS network for advancing radiology research.

Examples of Data Analysis with SPSS-X.

ERIC Educational Resources Information Center

MacFarland, Thomas W.

Intended for classroom use only, these unpublished notes contain computer lessons on descriptive statistics using SPSS-X Release 3.0 for VAX/UNIX. Statistical measures covered include Chi-square analysis; Spearman's rank correlation coefficient; Student's t-test with two independent samples; Student's t-test with a paired sample; One-way analysis…

OSTA commonality analysis, volume 2

NASA Technical Reports Server (NTRS)

Stolarik, E. G.

1981-01-01

The 13 OSTA disciplines are examined and the applications being performed under each discipline and the parameter requirements associated with the various applications are identified. It contains a variety of printouts from the commonality database built using DRS on the Vax. It also shows commonality of parameter requirements by discipline and by application.

Status Report on Image Information Systems and Image Data Base Technology

DTIC Science & Technology

1989-12-01

PowerHouse, StarGate , StarNet. Significant Recent Developments: Acceptance major teaching Universities (Australia), U.S.A.F. Major Corporations. Future...scenario, all computers must be VAX). STARBASE StarBase StarNet, (Network server), StarBase StarGate , (SQL gateway). SYBASE Sybase is an inherently

Scientific data bases on a VAX-11/780 running VMS

DOE Office of Scientific and Technical Information (OSTI.GOV)

Benkovitz, C.M.; Tichler, J.L.

At Brookhaven National Laboratory several current projects are developing and applying data management techniques to compile, analyze and distribute scientific data sets that are the result of various multi institutional experiments and data gathering projects. This paper will present an overview of a few of these data management projects.

DG TO FT - AUTOMATIC TRANSLATION OF DIGRAPH TO FAULT TREE MODELS

NASA Technical Reports Server (NTRS)

Iverson, D. L.

1994-01-01

Fault tree and digraph models are frequently used for system failure analysis. Both types of models represent a failure space view of the system using AND and OR nodes in a directed graph structure. Each model has its advantages. While digraphs can be derived in a fairly straightforward manner from system schematics and knowledge about component failure modes and system design, fault tree structure allows for fast processing using efficient techniques developed for tree data structures. The similarities between digraphs and fault trees permits the information encoded in the digraph to be translated into a logically equivalent fault tree. The DG TO FT translation tool will automatically translate digraph models, including those with loops or cycles, into fault tree models that have the same minimum cut set solutions as the input digraph. This tool could be useful, for example, if some parts of a system have been modeled using digraphs and others using fault trees. The digraphs could be translated and incorporated into the fault trees, allowing them to be analyzed using a number of powerful fault tree processing codes, such as cut set and quantitative solution codes. A cut set for a given node is a group of failure events that will cause the failure of the node. A minimum cut set for a node is any cut set that, if any of the failures in the set were to be removed, the occurrence of the other failures in the set will not cause the failure of the event represented by the node. Cut sets calculations can be used to find dependencies, weak links, and vital system components whose failures would cause serious systems failure. The DG TO FT translation system reads in a digraph with each node listed as a separate object in the input file. The user specifies a terminal node for the digraph that will be used as the top node of the resulting fault tree. A fault tree basic event node representing the failure of that digraph node is created and becomes a child of the terminal root node. A subtree is created for each of the inputs to the digraph terminal node and the root of those subtrees are added as children of the top node of the fault tree. Every node in the digraph upstream of the terminal node will be visited and converted. During the conversion process, the algorithm keeps track of the path from the digraph terminal node to the current digraph node. If a node is visited twice, then the program has found a cycle in the digraph. This cycle is broken by finding the minimal cut sets of the twice visited digraph node and forming those cut sets into subtrees. Another implementation of the algorithm resolves loops by building a subtree based on the digraph minimal cut sets calculation. It does not reduce the subtree to minimal cut set form. This second implementation produces larger fault trees, but runs much faster than the version using minimal cut sets since it does not spend time reducing the subtrees to minimal cut sets. The fault trees produced by DG TO FT will contain OR gates, AND gates, Basic Event nodes, and NOP gates. The results of a translation can be output as a text object description of the fault tree similar to the text digraph input format. The translator can also output a LISP language formatted file and an augmented LISP file which can be used by the FTDS (ARC-13019) diagnosis system, available from COSMIC, which performs diagnostic reasoning using the fault tree as a knowledge base. DG TO FT is written in C-language to be machine independent. It has been successfully implemented on a Sun running SunOS, a DECstation running ULTRIX, a Macintosh running System 7, and a DEC VAX running VMS. The RAM requirement varies with the size of the models. DG TO FT is available in UNIX tar format on a .25 inch streaming magnetic tape cartridge (standard distribution) or on a 3.5 inch diskette. It is also available on a 3.5 inch Macintosh format diskette or on a 9-track 1600 BPI magnetic tape in DEC VAX FILES-11 format. Sample input and sample output are provided on the distribution medium. An electronic copy of the documentation in Macintosh Microsoft Word format is provided on the distribution medium. DG TO FT was developed in 1992. Sun, and SunOS are trademarks of Sun Microsystems, Inc. DECstation, ULTRIX, VAX, and VMS are trademarks of Digital Equipment Corporation. UNIX is a registered trademark of AT&T Bell Laboratories. Macintosh is a registered trademark of Apple Computer, Inc. System 7 is a trademark of Apple Computers Inc. Microsoft Word is a trademark of Microsoft Corporation.

Mechanical Component Diagnostic System

DTIC Science & Technology

1991-01-01

Control and Display Unit ( CADU ) executes the system software and controls data acquisition that is carried out by 6 the Data Acquisition Unit (DAU... CADU screen. Displays intended for the CD are also echoed on the CADU in the FDR backup mode. If initialization is successful, clocks are synchronized...and normal MCDS monitoring mode is entered. If there is no display on the CD, the user may manually switch to the backup CD display on the CADU . Hence

Mechanical Backup For Fly-By-Wire Control System

NASA Technical Reports Server (NTRS)

Stewart, Eric C.

1992-01-01

Mechanical device eliminates need for redundant fly-by-wire subsystems. Main components are two linkages. One connected to control column in conventional, reversible control system. Other slides inside first linkage and connected to pilot's control wheel. In addition to aircraft applications, design used in control systems in which computer control desirable but safety backup systems required; for example, in boat rudders, engine controls in boats and automobiles, and controls in construction equipment.

Protection of Mission-Critical Applications from Untrusted Execution Environment: Resource Efficient Replication and Migration of Virtual Machines

DTIC Science & Technology

2015-09-28

the performance of log-and- replay can degrade significantly for VMs configured with multiple virtual CPUs, since the shared memory communication...whether based on checkpoint replication or log-and- replay , existing HA ap- proaches use in- memory backups. The backup VM sits in the memory of a...efficiently. 15. SUBJECT TERMS High-availability virtual machines, live migration, memory and traffic overheads, application suspension, Java

115. VIEW OF SOUTHWEST CORNER OF LANDLINE INSTRUMENTATION ROOM (206), ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

115. VIEW OF SOUTHWEST CORNER OF LANDLINE INSTRUMENTATION ROOM (206), LSB (BLDG. 751). BATTERY RACK ON LEFT FOR BACKUP BOOSTER POWER; BATTERY RACK ON RIGHT FOR BACKUP AEROSPACE GROUND EQUIPMENT (AGE) POWER. RECTIFIER SUPPLYING PRIMARY POWER ON THE RIGHT SIDE OF THE PHOTO; BATTERY CHARGER BETWEEN RECTIFIER AND BATTERY RACKS. - Vandenberg Air Force Base, Space Launch Complex 3, Launch Pad 3 East, Napa & Alden Roads, Lompoc, Santa Barbara County, CA

Backup of Renewable Energy for an Electrical Island: Case Study of Israeli Electricity System—Current Status

PubMed Central

Fakhouri, A.; Kuperman, A.

2014-01-01

The paper focuses on the quantitative analysis of Israeli Government's targets of 10% renewable energy penetration by 2020 and determining the desired methodology (models) for assessing the effects on the electricity market, addressing the fact that Israel is an electricity island. The main objective is to determine the influence of achieving the Government's goals for renewable energy penetration on the need for backup in the Israeli electricity system. This work presents the current situation of the Israeli electricity market and the study to be taken in order to assess the undesirable effects resulting from the intermittency of electricity generated by wind and solar power stations as well as presents some solutions to mitigating these phenomena. Future work will focus on a quantitative analysis of model runs and determine the amounts of backup required relative to the amount of installed capacity from renewable resources. PMID:24624044

Analog neural network control method proposed for use in a backup satellite control mode

DOE Office of Scientific and Technical Information (OSTI.GOV)

Frigo, J.R.; Tilden, M.W.

1998-03-01

The authors propose to use an analog neural network controller implemented in hardware, independent of the active control system, for use in a satellite backup control mode. The controller uses coarse sun sensor inputs. The field of view of the sensors activate the neural controller, creating an analog dead band with respect to the direction of the sun on each axis. This network controls the orientation of the vehicle toward the sunlight to ensure adequate power for the system. The attitude of the spacecraft is stabilized with respect to the ambient magnetic field on orbit. This paper develops a modelmore » of the controller using real-time coarse sun sensor data and a dynamic model of a prototype system based on a satellite system. The simulation results and the feasibility of this control method for use in a satellite backup control mode are discussed.« less

Backup of renewable energy for an electrical island: case study of Israeli electricity system--current status.

PubMed

Fakhouri, A; Kuperman, A

2014-01-01

The paper focuses on the quantitative analysis of Israeli Government's targets of 10% renewable energy penetration by 2020 and determining the desired methodology (models) for assessing the effects on the electricity market, addressing the fact that Israel is an electricity island. The main objective is to determine the influence of achieving the Government's goals for renewable energy penetration on the need for backup in the Israeli electricity system. This work presents the current situation of the Israeli electricity market and the study to be taken in order to assess the undesirable effects resulting from the intermittency of electricity generated by wind and solar power stations as well as presents some solutions to mitigating these phenomena. Future work will focus on a quantitative analysis of model runs and determine the amounts of backup required relative to the amount of installed capacity from renewable resources.

Apollo 13 MCC - MSC

NASA Image and Video Library

1970-04-14

S70-34986 (14 April 1970) --- A group of six astronauts and two flight controllers monitor the console activity in the Mission Operations Control Room (MOCR) of the Mission Control Center (MCC) during the problem-plagued Apollo 13 lunar landing mission. Seated, left to right, are MOCR Guidance Officer Raymond F. Teague; astronaut Edgar D. Mitchell, Apollo 14 prime crew lunar module pilot; and astronaut Alan B. Shepard Jr., Apollo 14 prime crew commander. Standing, left to right, are scientist-astronaut Anthony W. England; astronaut Joe H. Engle, Apollo 14 backup crew lunar module pilot; astronaut Eugene A. Cernan, Apollo 14 backup crew commander; astronaut Ronald E. Evans, Apollo 14 backup crew command module pilot; and M.P. Frank, a flight controller. When this picture was made, the Apollo 13 moon landing had already been canceled, and the Apollo 13 crew men were in trans-Earth trajectory attempting to bring their damaged spacecraft back home.

Influence of backup bearings and support structure dynamics on the behavior of rotors with active supports

NASA Technical Reports Server (NTRS)

Flowers, George T.

1994-01-01

Substantial progress has been made toward the goals of this research effort in the past six months. A simplified rotor model with a flexible shaft and backup bearings has been developed. The model is based upon the work of Ishii and Kirk. Parameter studies of the behavior of this model are currently being conducted. A simple rotor model which includes a flexible disk and bearings with clearance has been developed and the dynamics of the model investigated. The study consists of simulation work coupled with experimental verification. The work is documented in the attached paper. A rotor model based upon the T-501 engine has been developed which includes backup bearing effects. The dynamics of this model are currently being studied with the objective of verifying the conclusions obtained from the simpler models. Parallel simulation runs are being conducted using an ANSYS based finite element model of the T-501.

The Unparalleled Systems Engineering of MSL's Backup Entry, Descent, and Landing System: Second Chance

NASA Technical Reports Server (NTRS)

Roumeliotis, Chris; Grinblat, Jonathan; Reeves, Glenn

2013-01-01

Second Chance (SECC) was a bare bones version of Mars Science Laboratory's (MSL) Entry Descent & Landing (EDL) flight software that ran on Curiosity's backup computer, which could have taken over swiftly in the event of a reset of Curiosity's prime computer, in order to land her safely on Mars. Without SECC, a reset of Curiosity's prime computer would have lead to catastrophic mission failure. Even though a reset of the prime computer never occurred, SECC had the important responsibility as EDL's guardian angel, and this responsibility would not have seen such success without unparalleled systems engineering. This paper will focus on the systems engineering behind SECC: Covering a brief overview of SECC's design, the intense schedule to use SECC as a backup system, the verification and validation of the system's "Do No Harm" mandate, the system's overall functional performance, and finally, its use on the fateful day of August 5th, 2012.

A hierarchical storage management (HSM) scheme for cost-effective on-line archival using lossy compression.

PubMed

Avrin, D E; Andriole, K P; Yin, L; Gould, R G; Arenson, R L

2001-03-01

A hierarchical storage management (HSM) scheme for cost-effective on-line archival of image data using lossy compression is described. This HSM scheme also provides an off-site tape backup mechanism and disaster recovery. The full-resolution image data are viewed originally for primary diagnosis, then losslessly compressed and sent off site to a tape backup archive. In addition, the original data are wavelet lossy compressed (at approximately 25:1 for computed radiography, 10:1 for computed tomography, and 5:1 for magnetic resonance) and stored on a large RAID device for maximum cost-effective, on-line storage and immediate retrieval of images for review and comparison. This HSM scheme provides a solution to 4 problems in image archiving, namely cost-effective on-line storage, disaster recovery of data, off-site tape backup for the legal record, and maximum intermediate storage and retrieval through the use of on-site lossy compression.

STS-47 crew during fire fighting exercises at JSC's Fire Training Pit

NASA Technical Reports Server (NTRS)

1992-01-01

STS-47 Endeavour, Orbiter Vehicle (OV) 105, crewmembers line up along water hoses to extinguish a blaze in JSC's Fire Training Pit during fire fighting exercises. Manning the hose in the foreground are Payload Specialist Mamoru Mohri, holding the hose nozzle, backup Payload Specialist Takao Doi, Mission Specialist (MS) Jerome Apt, and Commander Robert L. Gibson, at rear. Lined up on the second hose are Pilot Curtis L. Brown, Jr, holding the hose nozzle, followed by MS N. Jan Davis, MS and Payload Commander (PLC) Mark C. Lee, and backup Payload Specialist Stan Koszelak. A veteran firefighter monitors the effort from a position between the two hoses. In the background, backup Payload Specialist Chiaki Naito-Mukai, donning gloves, and MS Mae C. Jemison look on. The Fire Training Pit is located across from the Gilruth Center Bldg 207. Mohri, Doi, and Mukai all represent Japan's National Space Development Agency (NASDA).

jsc2017e136057 - On a snowy night at Red Square Moscow, Expedition 54-55 backup crewmembers Sergey Prokopyev of the Russian Federal Space Agency (Roscosmos, left), Jeanette Epps of NASA (center) and Alexander Gerst of the European Space Agency (right) pay

NASA Image and Video Library

2017-11-30

jsc2017e136057 - On a snowy night at Red Square Moscow, Expedition 54-55 backup crewmembers Sergey Prokopyev of the Russian Federal Space Agency (Roscosmos, left), Jeanette Epps of NASA (center) and Alexander Gerst of the European Space Agency (right) pay homage at the Kremlin Wall where Russian space icons are interred in traditional pre-launch ceremonies Nov. 30. They are backups to Anton Shkaplerov of Roscosmos, Scott Tingle of NASA and Norishige Kanai of the Japan Aerospace Exploration Agency (JAXA), who will launch from the Baikonur Cosmodrome in Kazakhstan on the Soyuz MS-07 spacecraft Dec. 17 for a five-month mission on the International Space Station...Andrey Shelepin/Gagarin Cosmonaut Training Center.

Poly(ADP-ribose)polymerases are involved in microhomology mediated back-up non-homologous end joining in Arabidopsis thaliana.

PubMed

Jia, Qi; den Dulk-Ras, Amke; Shen, Hexi; Hooykaas, Paul J J; de Pater, Sylvia

2013-07-01

Besides the KU-dependent classical non-homologous end-joining (C-NHEJ) pathway, an alternative NHEJ pathway first identified in mammalian systems, which is often called the back-up NHEJ (B-NHEJ) pathway, was also found in plants. In mammalian systems PARP was found to be one of the essential components in B-NHEJ. Here we investigated whether PARP1 and PARP2 were also involved in B-NHEJ in Arabidopsis. To this end Arabidopsis parp1, parp2 and parp1parp2 (p1p2) mutants were isolated and functionally characterized. The p1p2 double mutant was crossed with the C-NHEJ ku80 mutant resulting in the parp1parp2ku80 (p1p2k80) triple mutant. As expected, because of their role in single strand break repair (SSBR) and base excision repair (BER), the p1p2 and p1p2k80 mutants were shown to be sensitive to treatment with the DNA damaging agent MMS. End-joining assays in cell-free leaf protein extracts of the different mutants using linear DNA substrates with different ends reflecting a variety of double strand breaks were performed. The results showed that compatible 5'-overhangs were accurately joined in all mutants, that KU80 protected the ends preventing the formation of large deletions and that PARP proteins were involved in microhomology mediated end joining (MMEJ), one of the characteristics of B-NHEJ.

FTC - THE FAULT-TREE COMPILER (SUN VERSION)

NASA Technical Reports Server (NTRS)

Butler, R. W.

1994-01-01

FTC, the Fault-Tree Compiler program, is a tool used to calculate the top-event probability for a fault-tree. Five different gate types are allowed in the fault tree: AND, OR, EXCLUSIVE OR, INVERT, and M OF N. The high-level input language is easy to understand and use. In addition, the program supports a hierarchical fault tree definition feature which simplifies the tree-description process and reduces execution time. A rigorous error bound is derived for the solution technique. This bound enables the program to supply an answer precisely (within the limits of double precision floating point arithmetic) at a user-specified number of digits accuracy. The program also facilitates sensitivity analysis with respect to any specified parameter of the fault tree such as a component failure rate or a specific event probability by allowing the user to vary one failure rate or the failure probability over a range of values and plot the results. The mathematical approach chosen to solve a reliability problem may vary with the size and nature of the problem. Although different solution techniques are utilized on different programs, it is possible to have a common input language. The Systems Validation Methods group at NASA Langley Research Center has created a set of programs that form the basis for a reliability analysis workstation. The set of programs are: SURE reliability analysis program (COSMIC program LAR-13789, LAR-14921); the ASSIST specification interface program (LAR-14193, LAR-14923), PAWS/STEM reliability analysis programs (LAR-14165, LAR-14920); and the FTC fault tree tool (LAR-14586, LAR-14922). FTC is used to calculate the top-event probability for a fault tree. PAWS/STEM and SURE are programs which interpret the same SURE language, but utilize different solution methods. ASSIST is a preprocessor that generates SURE language from a more abstract definition. SURE, ASSIST, and PAWS/STEM are also offered as a bundle. Please see the abstract for COS-10039/COS-10041, SARA - SURE/ASSIST Reliability Analysis Workstation, for pricing details. FTC was originally developed for DEC VAX series computers running VMS and was later ported for use on Sun computers running SunOS. The program is written in PASCAL, ANSI compliant C-language, and FORTRAN 77. The TEMPLATE graphics library is required to obtain graphical output. The standard distribution medium for the VMS version of FTC (LAR-14586) is a 9-track 1600 BPI magnetic tape in VMSINSTAL format. It is also available on a TK50 tape cartridge in VMSINSTAL format. Executables are included. The standard distribution medium for the Sun version of FTC (LAR-14922) is a .25 inch streaming magnetic tape cartridge in UNIX tar format. Both Sun3 and Sun4 executables are included. FTC was developed in 1989 and last updated in 1992. DEC, VAX, VMS, and TK50 are trademarks of Digital Equipment Corporation. UNIX is a registered trademark of AT&T Bell Laboratories. SunOS is a trademark of Sun Microsystems, Inc.

A Chang'e-4 mission concept and vision of future Chinese lunar exploration activities

NASA Astrophysics Data System (ADS)

Wang, Qiong; Liu, Jizhong

2016-10-01

A novel concept for Chinese Chang'e-4 lunar exploration mission is presented in this paper at first. After the success of Chang'e-3, its backup probe, Chang'e-4 lander/rover combination, would be upgraded and land on the unexplored lunar farside by the aid of a relay satellite near the second Earth-Moon Lagrange point. Mineralogical and geochemical surveys on the farside to study the formation and evolution of lunar crust and observations at low radio frequencies to track the signals of the Universe's Dark Ages are priorities. Follow-up Chinese lunar exploration activities before 2030 are envisioned as building a robotic lunar science station by three to five missions. Finally several methods of international cooperation are proposed.

One Dimension Analytical Model of Normal Ballistic Impact on Ceramic/Metal Gradient Armor

NASA Astrophysics Data System (ADS)

Liu, Lisheng; Zhang, Qingjie; Zhai, Pengcheng; Cao, Dongfeng

2008-02-01

An analytical model of normal ballistic impact on the ceramic/metal gradient armor, which is based on modified Alekseevskii-Tate equations, has been developed. The process of gradient armour impacted by the long rod can be divided into four stages in this model. First stage is projectile's mass erosion or flowing phase, mushrooming phase and rigid phase; second one is the formation of comminuted ceramic conoid; third one is the penetration of gradient layer and last one is the penetration of metal back-up plate. The equations of third stage have been advanced by assuming the behavior of gradient layer as rigid-plastic and considering the effect of strain rate on the dynamic yield strength.

One Dimension Analytical Model of Normal Ballistic Impact on Ceramic/Metal Gradient Armor

DOE Office of Scientific and Technical Information (OSTI.GOV)

Liu Lisheng; Zhang Qingjie; Zhai Pengcheng

2008-02-15

An analytical model of normal ballistic impact on the ceramic/metal gradient armor, which is based on modified Alekseevskii-Tate equations, has been developed. The process of gradient armour impacted by the long rod can be divided into four stages in this model. First stage is projectile's mass erosion or flowing phase, mushrooming phase and rigid phase; second one is the formation of comminuted ceramic conoid; third one is the penetration of gradient layer and last one is the penetration of metal back-up plate. The equations of third stage have been advanced by assuming the behavior of gradient layer as rigid-plastic andmore » considering the effect of strain rate on the dynamic yield strength.« less

STS 51-L crewmembers briefed during training session

NASA Technical Reports Server (NTRS)

1986-01-01

Five members of the STS 51-L crew and a backup crewmember are briefed during a training session in JSC's Shuttle mockup and integration laboratory. From left to right are Astronauts Ellison S. Onizuka, mission specialist; Ronald E. McNair, mission specialist; Gregory Jarvis, Hughes payload specialist; Judith A. Resnik, mission specialist; Sharon Christa McAuliffe, citizen observer/payload specialist representing the Teacher in Space project. Barbara R. Morgan, backup to McAuliffe, is in the right foreground.

jsc2017e136942 - In the town of Baikonur, Kazakhstan, Expedition 54-55 backup crewmembers Jeanette Epps of NASA, Sergey Prokopyev of the Russian Federal Space Agency (Roscosmos) and Alexander Gerst of the European Space Agency lay flowers Dec. 6 at the sta

NASA Image and Video Library

2017-12-06

jsc2017e136942 - In the town of Baikonur, Kazakhstan, Expedition 54-55 backup crewmembers Jeanette Epps of NASA, Sergey Prokopyev of the Russian Federal Space Agency (Roscosmos) and Alexander Gerst of the European Space Agency lay flowers Dec. 6 at the sta

jsc2017e136944 - In the town of Baikonur, Kazakhstan, Expedition 54-55 backup crewmembers Jeanette Epps of NASA, Sergey Prokopyev of the Russian Federal Space Agency (Roscosmos) and Alexander Gerst of the European Space Agency lay flowers Dec. 6 at the sta

NASA Image and Video Library

2017-12-06

jsc2017e136944 - In the town of Baikonur, Kazakhstan, Expedition 54-55 backup crewmembers Jeanette Epps of NASA, Sergey Prokopyev of the Russian Federal Space Agency (Roscosmos) and Alexander Gerst of the European Space Agency lay flowers Dec. 6 at the sta

GENERAL PURPOSE ADA PACKAGES

NASA Technical Reports Server (NTRS)

Klumpp, A. R.

1994-01-01

Ten families of subprograms are bundled together for the General-Purpose Ada Packages. The families bring to Ada many features from HAL/S, PL/I, FORTRAN, and other languages. These families are: string subprograms (INDEX, TRIM, LOAD, etc.); scalar subprograms (MAX, MIN, REM, etc.); array subprograms (MAX, MIN, PROD, SUM, GET, and PUT); numerical subprograms (EXP, CUBIC, etc.); service subprograms (DATE_TIME function, etc.); Linear Algebra II; Runge-Kutta integrators; and three text I/O families of packages. In two cases, a family consists of a single non-generic package. In all other cases, a family comprises a generic package and its instances for a selected group of scalar types. All generic packages are designed to be easily instantiated for the types declared in the user facility. The linear algebra package is LINRAG2. This package includes subprograms supplementing those in NPO-17985, An Ada Linear Algebra Package Modeled After HAL/S (LINRAG). Please note that LINRAG2 cannot be compiled without LINRAG. Most packages have widespread applicability, although some are oriented for avionics applications. All are designed to facilitate writing new software in Ada. Several of the packages use conventions introduced by other programming languages. A package of string subprograms is based on HAL/S (a language designed for the avionics software in the Space Shuttle) and PL/I. Packages of scalar and array subprograms are taken from HAL/S or generalized current Ada subprograms. A package of Runge-Kutta integrators is patterned after a built-in MAC (MIT Algebraic Compiler) integrator. Those packages modeled after HAL/S make it easy to translate existing HAL/S software to Ada. The General-Purpose Ada Packages program source code is available on two 360K 5.25" MS-DOS format diskettes. The software was developed using VAX Ada v1.5 under DEC VMS v4.5. It should be portable to any validated Ada compiler and it should execute either interactively or in batch. The largest package requires 205K of main memory on a DEC VAX running VMS. The software was developed in 1989, and is a copyrighted work with all copyright vested in NASA.

AN Integrated Bibliographic Information System: Concept and Application for Resource Sharing in Special Libraries

DTIC Science & Technology

1987-05-01

workload (beyond that of say an equivalent academic or corporate technical libary ) for the Defense Department libraries. Figure 9 illustrates the range...summer. The hardware configuration for the system is as follows: " Digital Equipment Corporation VAX 11/750 central processor with 6 mega- bytes of real

ADAPTATION OF THE ADVANCED STATISTICAL TRAJECTORY REGIONAL AIR POLLUTION (ASTRAP) MODEL TO THE EPA VAX COMPUTER - MODIFICATIONS AND TESTING

EPA Science Inventory

The Advanced Statistical Trajectory Regional Air Pollution (ASTRAP) model simulates long-term transport and deposition of oxides of and nitrogen. t is a potential screening tool for assessing long-term effects on regional visibility from sulfur emission sources. owever, a rigorou...

EDT mode for JED -- An advanced Unix text editor

NASA Astrophysics Data System (ADS)

McIlwrath, B. K.; Page, C. G.

This note describes Starlink extended EDT emulation for the JED editor. It provides a Unix text editor which can utilise the advanced facilities of DEC VTn00, xterm and similar terminals. JED in this mode provides a reasonably good emulation of the VAX/VMS editor EDT in addition to many extra facilities.

Applications of artificial intelligence to mission planning

NASA Technical Reports Server (NTRS)

Ford, Donnie R.; Floyd, Stephen A.; Rogers, John S.

1990-01-01

The following subject areas are covered: object-oriented programming task; rule-based programming task; algorithms for resource allocation; connecting a Symbolics to a VAX; FORTRAN from Lisp; trees and forest task; software data structure conversion; software functionality modifications and enhancements; portability of resource allocation to a TI MicroExplorer; frontier of feasibility software system; and conclusions.

Library Automation Alternatives in 1996 and User Satisfaction Ratings of Library Users by Operating System.

ERIC Educational Resources Information Center

Cibbarelli, Pamela

1996-01-01

Examines library automation product introductions and conversions to new operating systems. Compares user satisfaction ratings of the following library software packages: DOS/Windows, UNIX, Macintosh, and DEC VAX/VMS. Software is rated according to documentation, service/support, training, product reliability, product capabilities, ease of use,…

Space station integrated wall design and penetration damage control

NASA Technical Reports Server (NTRS)

Coronado, A. R.; Gibbins, M. N.; Wright, M. A.; Stern, P. H.

1987-01-01

The analysis code BUMPER executes a numerical solution to the problem of calculating the probability of no penetration (PNP) of a spacecraft subject to man-made orbital debris or meteoroid impact. The codes were developed on a DEC VAX 11/780 computer that uses the Virtual Memory System (VMS) operating system, which is written in FORTRAN 77 with no VAX extensions. To help illustrate the steps involved, a single sample analysis is performed. The example used is the space station reference configuration. The finite element model (FEM) of this configuration is relatively complex but demonstrates many BUMPER features. The computer tools and guidelines are described for constructing a FEM for the space station under consideration. The methods used to analyze the sensitivity of PNP to variations in design, are described. Ways are suggested for developing contour plots of the sensitivity study data. Additional BUMPER analysis examples are provided, including FEMs, command inputs, and data outputs. The mathematical theory used as the basis for the code is described, and illustrates the data flow within the analysis.

Substitution of Wild-Type Yellow Fever Asibi Sequences for 17D Vaccine Sequences in ChimeriVax–Dengue 4 Does Not Enhance Infection of Aedes aegypti Mosquitoes

PubMed Central

McGee, Charles E.; Tsetsarkin, Konstantin; Vanlandingham, Dana L.; McElroy, Kate L.; Lang, Jean; Guy, Bruno; Decelle, Thierry; Higgs, Stephen

2008-01-01

To address concerns that a flavivirus vaccine/wild-type recombinant virus might have a high mosquito infectivity phenotype, the yellow fever virus (YFV) 17D backbone of the ChimeriVax– dengue 4 virus was replaced with the corresponding gene sequences of the virulent YFV Asibi strain. Field-collected and laboratory-colonized Aedes aegypti mosquitoes were fed on blood containing each of the viruses under investigation and held for 14 days after infection. Infection and dissemination rates were based on antigen detection in titrated body or head triturates. Our data indicate that, even in the highly unlikely event of recombination or substantial backbone reversion, virulent sequences do not enhance the transmissibility of ChimeriVax viruses. In light of the low-level viremias that have been observed after vaccination in human volunteers coupled with low mosquito infectivity, it is predicted that the risk of mosquito infection and transmission of ChimeriVax vaccine recombinant/revertant viruses in nature is minimal. PMID:18266608

Development of oral CTL vaccine using a CTP-integrated Sabin 1 poliovirus-based vector system.

PubMed

Han, Seung-Soo; Lee, Jinjoo; Jung, Yideul; Kang, Myeong-Ho; Hong, Jung-Hyub; Cha, Min-Suk; Park, Yu-Jin; Lee, Ezra; Yoon, Cheol-Hee; Bae, Yong-Soo

2015-09-11

We developed a CTL vaccine vector by modification of the RPS-Vax system, a mucosal vaccine vector derived from a poliovirus Sabin 1 strain, and generated an oral CTL vaccine against HIV-1. A DNA fragment encoding a cytoplasmic transduction peptide (CTP) was integrated into the RPS-Vax system to generate RPS-CTP, a CTL vaccine vector. An HIV-1 p24 cDNA fragment was introduced into the RPS-CTP vector system and a recombinant poliovirus (rec-PV) named vRPS-CTP/p24 was produced. vRPS-CTP/p24 was genetically stable and efficiently induced Th1 immunity and p24-specific CTLs in immunized poliovirus receptor-transgenic (PVR-Tg) mice. In challenge experiments, PVR-Tg mice that were pre-immunized orally with vRPS-CTP/p24 were resistant to challenge with a lethal dose of p24-expressing recombinant vaccinia virus (rMVA-p24). These results suggested that the RPS-CTP vector system had potential for developing oral CTL vaccines against infectious diseases. Copyright © 2015 Elsevier Ltd. All rights reserved.

Graphical workstation capability for reliability modeling

NASA Technical Reports Server (NTRS)

Bavuso, Salvatore J.; Koppen, Sandra V.; Haley, Pamela J.

1992-01-01

In addition to computational capabilities, software tools for estimating the reliability of fault-tolerant digital computer systems must also provide a means of interfacing with the user. Described here is the new graphical interface capability of the hybrid automated reliability predictor (HARP), a software package that implements advanced reliability modeling techniques. The graphics oriented (GO) module provides the user with a graphical language for modeling system failure modes through the selection of various fault-tree gates, including sequence-dependency gates, or by a Markov chain. By using this graphical input language, a fault tree becomes a convenient notation for describing a system. In accounting for any sequence dependencies, HARP converts the fault-tree notation to a complex stochastic process that is reduced to a Markov chain, which it can then solve for system reliability. The graphics capability is available for use on an IBM-compatible PC, a Sun, and a VAX workstation. The GO module is written in the C programming language and uses the graphical kernal system (GKS) standard for graphics implementation. The PC, VAX, and Sun versions of the HARP GO module are currently in beta-testing stages.

Chromosome thripsis by DNA double strand break clusters causes enhanced cell lethality, chromosomal translocations and 53BP1-recruitment

PubMed Central

Schipler, Agnes; Mladenova, Veronika; Soni, Aashish; Nikolov, Vladimir; Saha, Janapriya; Mladenov, Emil; Iliakis, George

2016-01-01

Chromosome translocations are hallmark of cancer and of radiation-induced cell killing, reflecting joining of incongruent DNA-ends that alter the genome. Translocation-formation requires DNA end-joining mechanisms and incompletely characterized, permissive chromatin conditions. We show that chromatin destabilization by clusters of DNA double-strand-breaks (DSBs) generated by the I-SceI meganuclease at multiple, appropriately engineered genomic sites, compromises c-NHEJ and markedly increases cell killing and translocation-formation compared to single-DSBs. Translocation-formation from DSB-clusters utilizes Parp1 activity, implicating alt-EJ in their formation. Immunofluorescence experiments show that single-DSBs and DSB-clusters uniformly provoke the formation of single γ-H2AX foci, suggesting similar activation of early DNA damage response (DDR). Live-cell imaging also shows similar single-focus recruitment of the early-response protein MDC1, to single-DSBs and DSB-clusters. Notably, the late DDR protein, 53BP1 shows in live-cell imaging strikingly stronger recruitment to DSB-clusters as compared to single-DSBs. This is the first report that chromatin thripsis, in the form of engineered DSB-clusters, compromises first-line DSB-repair pathways, allowing alt-EJ to function as rescuing-backup. DSB-cluster-formation is indirectly linked to the increased biological effectiveness of high ionization-density radiations, such as the alpha-particles emitted by radon gas or the heavy-ions utilized in cancer therapy. Our observations provide the first direct mechanistic explanation for this long-known effect. PMID:27257076

DOMe: A deduplication optimization method for the NewSQL database backups

PubMed Central

Wang, Longxiang; Zhu, Zhengdong; Zhang, Xingjun; Wang, Yinfeng

2017-01-01

Reducing duplicated data of database backups is an important application scenario for data deduplication technology. NewSQL is an emerging database system and is now being used more and more widely. NewSQL systems need to improve data reliability by periodically backing up in-memory data, resulting in a lot of duplicated data. The traditional deduplication method is not optimized for the NewSQL server system and cannot take full advantage of hardware resources to optimize deduplication performance. A recent research pointed out that the future NewSQL server will have thousands of CPU cores, large DRAM and huge NVRAM. Therefore, how to utilize these hardware resources to optimize the performance of data deduplication is an important issue. To solve this problem, we propose a deduplication optimization method (DOMe) for NewSQL system backup. To take advantage of the large number of CPU cores in the NewSQL server to optimize deduplication performance, DOMe parallelizes the deduplication method based on the fork-join framework. The fingerprint index, which is the key data structure in the deduplication process, is implemented as pure in-memory hash table, which makes full use of the large DRAM in NewSQL system, eliminating the performance bottleneck problem of fingerprint index existing in traditional deduplication method. The H-store is used as a typical NewSQL database system to implement DOMe method. DOMe is experimentally analyzed by two representative backup data. The experimental results show that: 1) DOMe can reduce the duplicated NewSQL backup data. 2) DOMe significantly improves deduplication performance by parallelizing CDC algorithms. In the case of the theoretical speedup ratio of the server is 20.8, the speedup ratio of DOMe can achieve up to 18; 3) DOMe improved the deduplication throughput by 1.5 times through the pure in-memory index optimization method. PMID:29049307

Backup Attitude Control Algorithms for the MAP Spacecraft

NASA Technical Reports Server (NTRS)

ODonnell, James R., Jr.; Andrews, Stephen F.; Ericsson-Jackson, Aprille J.; Flatley, Thomas W.; Ward, David K.; Bay, P. Michael

1999-01-01

The Microwave Anisotropy Probe (MAP) is a follow-on to the Differential Microwave Radiometer (DMR) instrument on the Cosmic Background Explorer (COBE) spacecraft. The MAP spacecraft will perform its mission, studying the early origins of the universe, in a Lissajous orbit around the Earth-Sun L(sub 2) Lagrange point. Due to limited mass, power, and financial resources, a traditional reliability concept involving fully redundant components was not feasible. This paper will discuss the redundancy philosophy used on MAP, describe the hardware redundancy selected (and why), and present backup modes and algorithms that were designed in lieu of additional attitude control hardware redundancy to improve the odds of mission success. Three of these modes have been implemented in the spacecraft flight software. The first onboard mode allows the MAP Kalman filter to be used with digital sun sensor (DSS) derived rates, in case of the failure of one of MAP's two two-axis inertial reference units. Similarly, the second onboard mode allows a star tracker only mode, using attitude and derived rate from one or both of MAP's star trackers for onboard attitude determination and control. The last backup mode onboard allows a sun-line angle offset to be commanded that will allow solar radiation pressure to be used for momentum management and orbit stationkeeping. In addition to the backup modes implemented on the spacecraft, two backup algorithms have been developed in the event of less likely contingencies. One of these is an algorithm for implementing an alternative scan pattern to MAP's nominal dual-spin science mode using only one or two reaction wheels and thrusters. Finally, an algorithm has been developed that uses thruster one shots while in science mode for momentum management. This algorithm has been developed in case system momentum builds up faster than anticipated, to allow adequate momentum management while minimizing interruptions to science. In this paper, each mode and algorithm will be discussed, and simulation results presented.

Evaluation of the persistence, integration, histopathology and environmental release of DNA vaccine encoding Eimeria tenella TA4 and chicken IL-2.

PubMed

Song, Xiaokai; Zhang, Zeyang; Liu, Chang; Xu, Lixin; Yan, Ruofeng; Li, Xiangrui

2016-10-15

In a previous study, the construction of the Eimeria tenella DNA vaccine pVAX1.0-TA4-IL-2 which provides effective protection against coccidiosis was described and the immunization procedure was optimized. However, the persistence, integration, histopathology and environmental release of the DNA vaccine remain unknown. In this study, the persistence, integration and histopathology of the DNA vaccine pVAX1.0-TA4-IL-2 was evaluated in chickens in the following immunization studies: (1) single-dose immunization in one-day-old chickens; (2) repeat-dose immunization in chickens; and (3) single-high-dose immunization of three batches of plasmid in chickens. The persistence, integration, histopathology of the DNA vaccine was also evaluated in mice. At 1, 1.5, 2-4 months post immunization, blood, duodenum, heart, liver, spleen, kidneys and the immunized muscle tissue were collected from ten animals of each group. Persistence and integration were evaluated using PCR with a confirmed sensitivity of 30 plasmid copies. Hematoxylin and eosin stained sections were examined for the presence of inflammation or abnormalities that may result from vaccination. Water and fecal samples were also collected from the chicken enclosures to evaluate the potential for environmental release of the DNA vaccine. Testing various tissues by PCR confirmed that plasmid DNA persisted 1.5 months in blood, heart, liver and spleen, 2 months in kidneys and muscle of injected site. Furthermore, the vaccine did not integrate with the host genome. The histopathological examinations did not show obvious inflammation or pathological damage in any tissue of the immunized chickens. Similar results were observed in mice. Moreover, the DNA vaccine was not released into the surrounding environment. These results indicate that the DNA vaccine pVAX1.0-TA4-IL-2 has potential as safe vaccine against coccidiosis. Copyright © 2016 Elsevier B.V. All rights reserved.

VaxCelerate II: Rapid development of a self-assembling vaccine for Lassa fever

PubMed Central

Leblanc, Pierre; Moise, Leonard; Luza, Cybelle; Chantaralawan, Kanawat; Lezeau, Lynchy; Yuan, Jianping; Field, Mary; Richer, Daniel; Boyle, Christine; Martin, William D; Fishman, Jordan B; Berg, Eric A; Baker, David; Zeigler, Brandon; Mais, Dale E; Taylor, William; Coleman, Russell; Warren, H Shaw; Gelfand, Jeffrey A; De Groot, Anne S; Brauns, Timothy; Poznansky, Mark C

2014-01-01

Development of effective vaccines against emerging infectious diseases (EID) can take as much or more than a decade to progress from pathogen isolation/identification to clinical approval. As a result, conventional approaches fail to produce field-ready vaccines before the EID has spread extensively. Lassa is a prototypical emerging infectious disease endemic to West Africa for which no successful vaccine is available. We established the VaxCelerate Consortium to address the need for more rapid vaccine development by creating a platform capable of generating and pre-clinically testing a new vaccine against specific pathogen targets in less than 120 d. A self-assembling vaccine is at the core of the approach. It consists of a fusion protein composed of the immunostimulatory Mycobacterium tuberculosis heat shock protein 70 (MtbHSP70) and the biotin binding protein, avidin. Mixing the resulting protein (MAV) with biotinylated pathogen-specific immunogenic peptides yields a self-assembled vaccine (SAV). To meet the time constraint imposed on this project, we used a distributed R&D model involving experts in the fields of protein engineering and production, bioinformatics, peptide synthesis/design and GMP/GLP manufacturing and testing standards. SAV immunogenicity was first tested using H1N1 influenza specific peptides and the entire VaxCelerate process was then tested in a mock live-fire exercise targeting Lassa fever virus. We demonstrated that the Lassa fever vaccine induced significantly increased class II peptide specific interferon-γ CD4+ T cell responses in HLA-DR3 transgenic mice compared to peptide or MAV alone controls. We thereby demonstrated that our SAV in combination with a distributed development model may facilitate accelerated regulatory review by using an identical design for each vaccine and by applying safety and efficacy assessment tools that are more relevant to human vaccine responses than current animal models. PMID:25483693

Induction of Protective Immunity against Toxoplasmosis in BALB/c Mice Vaccinated with Toxoplasma gondii Rhoptry-1

PubMed Central

Sonaimuthu, Parthasarathy; Ching, Xiao T.; Fong, Mun Y.; Kalyanasundaram, Ramaswamy; Lau, Yee L.

2016-01-01

Toxoplasma gondii is the causative agent for toxoplasmosis. The rhoptry protein 1 (ROP1) is secreted by rhoptry, an apical secretory organelle of the parasite. ROP1 plays an important role in host cell invasion. In this study, the efficacy of ROP1 as a vaccine candidate against toxoplasmosis was evaluated through intramuscular or subcutaneous injection of BALB/c mice followed by immunological characterization (humoral- and cellular-mediated) and lethal challenge against virulent T. gondii RH strain in BALB/c mice. Briefly, a recombinant DNA plasmid (pVAX1-GFP-ROP1) was expressed in CHO cells while expression of recombinant ROP1 protein (rROP1) was carried out in Escherichia coli expression system. Immunization study involved injection of the recombinant pVAX1-ROP1 and purified rROP1 into different group of mice. Empty vector and PBS served as two different types of negative controls. Results obtained demonstrated that ROP1 is an immunogenic antigen that induced humoral immune response whereby detection of a protein band with expected size of 43 kDa was observed against vaccinated mice sera through western blot analysis. ROP1 antigen was shown to elicit cellular-mediated immunity as well whereby stimulated splenocytes with total lysate antigen (TLA) and rROP1 from pVAX1-ROP1 and rROP1-immunized mice, respectively, readily proliferated and secreted large amount of IFN-γ (712 ± 28.1 pg/ml and 1457 ± 31.19 pg/ml, respectively) and relatively low IL-4 level (94 ± 14.5 pg/ml and 186 ± 14.17 pg/ml, respectively). These phenomena suggested that Th1-favored immunity was being induced. Vaccination with ROP1 antigen was able to provide partial protection in the vaccinated mice against lethal challenge with virulent RH strain of tachyzoites. These findings proposed that the ROP1 antigen is a potential candidate for the development of vaccine against toxoplasmosis. PMID:27303390

Quantitative genome-wide methylation analysis of high-grade non-muscle invasive bladder cancer

PubMed Central

Kitchen, Mark O.; Bryan, Richard T.; Emes, Richard D.; Glossop, John R.; Luscombe, Christopher; Cheng, K. K.; Zeegers, Maurice P.; James, Nicholas D.; Devall, Adam J.; Mein, Charles A.; Gommersall, Lyndon; Fryer, Anthony A.; Farrell, William E.

2016-01-01

ABSTRACT High-grade non-muscle invasive bladder cancer (HG-NMIBC) is a clinically unpredictable disease with greater risks of recurrence and progression relative to their low-intermediate-grade counterparts. The molecular events, including those affecting the epigenome, that characterize this disease entity in the context of tumor development, recurrence, and progression, are incompletely understood. We therefore interrogated genome-wide DNA methylation using HumanMethylation450 BeadChip arrays in 21 primary HG-NMIBC tumors relative to normal bladder controls. Using strict inclusion-exclusion criteria we identified 1,057 hypermethylated CpGs within gene promoter-associated CpG islands, representing 256 genes. We validated the array data by bisulphite pyrosequencing and examined 25 array-identified candidate genes in an independent cohort of 30 HG-NMIBC and 18 low-intermediate-grade NMIBC. These analyses revealed significantly higher methylation frequencies in high-grade tumors relative to low-intermediate-grade tumors for the ATP5G2, IRX1 and VAX2 genes (P<0.05), and similarly significant increases in mean levels of methylation in high-grade tumors for the ATP5G2, VAX2, INSRR, PRDM14, VSX1, TFAP2b, PRRX1, and HIST1H4F genes (P<0.05). Although inappropriate promoter methylation was not invariantly associated with reduced transcript expression, a significant association was apparent for the ARHGEF4, PON3, STAT5a, and VAX2 gene transcripts (P<0.05). Herein, we present the first genome-wide DNA methylation analysis in a unique HG-NMIBC cohort, showing extensive and discrete methylation changes relative to normal bladder and low-intermediate-grade tumors. The genes we identified hold significant potential as targets for novel therapeutic intervention either alone, or in combination, with more conventional therapeutic options in the treatment of this clinically unpredictable disease. PMID:26929985

VaxCelerate II: rapid development of a self-assembling vaccine for Lassa fever.

PubMed

Leblanc, Pierre; Moise, Leonard; Luza, Cybelle; Chantaralawan, Kanawat; Lezeau, Lynchy; Yuan, Jianping; Field, Mary; Richer, Daniel; Boyle, Christine; Martin, William D; Fishman, Jordan B; Berg, Eric A; Baker, David; Zeigler, Brandon; Mais, Dale E; Taylor, William; Coleman, Russell; Warren, H Shaw; Gelfand, Jeffrey A; De Groot, Anne S; Brauns, Timothy; Poznansky, Mark C

2014-01-01

Development of effective vaccines against emerging infectious diseases (EID) can take as much or more than a decade to progress from pathogen isolation/identification to clinical approval. As a result, conventional approaches fail to produce field-ready vaccines before the EID has spread extensively. Lassa is a prototypical emerging infectious disease endemic to West Africa for which no successful vaccine is available. We established the VaxCelerate Consortium to address the need for more rapid vaccine development by creating a platform capable of generating and pre-clinically testing a new vaccine against specific pathogen targets in less than 120 d A self-assembling vaccine is at the core of the approach. It consists of a fusion protein composed of the immunostimulatory Mycobacterium tuberculosis heat shock protein 70 (MtbHSP70) and the biotin binding protein, avidin. Mixing the resulting protein (MAV) with biotinylated pathogen-specific immunogenic peptides yields a self-assembled vaccine (SAV). To meet the time constraint imposed on this project, we used a distributed R&D model involving experts in the fields of protein engineering and production, bioinformatics, peptide synthesis/design and GMP/GLP manufacturing and testing standards. SAV immunogenicity was first tested using H1N1 influenza specific peptides and the entire VaxCelerate process was then tested in a mock live-fire exercise targeting Lassa fever virus. We demonstrated that the Lassa fever vaccine induced significantly increased class II peptide specific interferon-γ CD4(+) T cell responses in HLA-DR3 transgenic mice compared to peptide or MAV alone controls. We thereby demonstrated that our SAV in combination with a distributed development model may facilitate accelerated regulatory review by using an identical design for each vaccine and by applying safety and efficacy assessment tools that are more relevant to human vaccine responses than current animal models.

jsc2017e136939 - At the Cosmonaut Hotel crew quarters in Baikonur, Kazakhstan, the Expedition 54-55 backup crewmembers take a stroll down the Walk of Cosmonauts Dec. 6 to lay flowers in traditional pre-launch ceremonies. From left to right are Jeanette Epp

NASA Image and Video Library

2017-12-06

jsc2017e136939 - At the Cosmonaut Hotel crew quarters in Baikonur, Kazakhstan, the Expedition 54-55 backup crewmembers take a stroll down the Walk of Cosmonauts Dec. 6 to lay flowers in traditional pre-launch ceremonies. From left to right are Jeanette Epp

jsc2018e048512

NASA Image and Video Library

2018-05-14

jsc2018e048512 - Expedition 56 backup crewmember Anne McClain of NASA poses for pictures in the Kremlin gardens in Moscow May 14 as part of traditional pre-launch activities. McClain is serving as a backup to the prime crew, Serena Aunon-Chancellor of NASA, Sergey Prokopyev of Roscosmos and Alexander Gerst of the European Space Agency, who will launch June 6 from the Baikonur Cosmodrome in Kazakhstan on the Soyuz MS-09 spacecraft for a six month mission on the International Space Station...NASA/Elizabeth Weissinger.

Making Antarctic Atmospheric Electricity Data Available to Living with a Star and Climate Change Investigators

NASA Technical Reports Server (NTRS)

Bering, Edgar

2004-01-01

This proposal requests support for making the nearly three decades of Antarctic atmospheric electricity data available to more workers. Measurements of the vertical electric field and air-earth current density made at the Earth's surface in Antarctica have recently been shown to be of considerable interest to scientists interested in monitoring short-term Sun-Earth connections and long term climate change. Such measurements have been made off and on for more than three decades, primarily at Vostok and South Pole stations. There is no single place where all of these data can be obtained via the Internet in a contemporary format. The work proposed here will attempt to remedy this deficiency as much as possible. Data we know to be presently available include data from South Pole, 1982-86 and 1991-1993, and Vostok station, 1997-present. Data were taken at South Pole and Vostok in the 60's and O'S, but these may prove difficult to obtain in digital form. At present, only the University of Houston's 1991-1993 data are available on the Web. Unfortunately, they are stored on a server slated for retirement. Also, they are written VAX binary floating point, using the UCLA/Stanford/Michigan flatfile format (FLATDBMS), which is obscure to some users. We propose to combine and reformat the three available data sets plus any others we can obtain onto a newer server. We will use a more common and comprehensible format. Archival copies will be burned onto CD and/or DVD-ROM media. Finally we will register these data with the appropriate NASA data systems.

Low settings of the ventricular pacing output in patients dependent on a pacemaker: are they really safe?

PubMed

Schuchert, Andreas; Frese, Jens; Stammwitz, Ekkehard; Novák, Miroslav; Schleich, Arthur; Wagner, Stefan M; Meinertz, Thomas

2002-06-01

It is generally acknowledged that pacemaker output must be adjusted with a 100% voltage safety margin above the pacing threshold to avoid ineffective pacing, especially in patients dependent on pacemakers. The aim of this prospective crossover study was to assess the beat-to-beat safety of low outputs in patients who are dependent on a pacemaker between 2 follow-up examinations. The study included 12 patients who had received a DDD pacemaker with an automatic beat-to-beat capture verification function. The ventricular output at 0.4 milliseconds pulse duration was programmed independently of the actual pacing threshold in a crossover randomization to 1.0 V, 1.5 V, and 2.5 V for 6 weeks each. At each follow-up, the diagnostic counters were interrogated and the pacing threshold at 0.4 milliseconds was determined in 0.1-V steps. The diagnostic pacemaker counters depict the frequency of back-up pulses delivered because of a loss of capture. During the randomization to 1.0-V output, we evaluated whether the adjustment of the output under consideration of the >100% voltage safety margin reduced the frequency of back-up pulses. Pacing thresholds at the randomization to 1.0-V, 1.5-V, and 2.5-V output were not significantly different, with 0.7 +/- 0.3 V at 2.5-V output, 0.6 +/- 0.2 V at 1.5-V output, and 0.6 +/- 0.2 V at 1.0-V output. The frequency of back-up pulses was similar at 2.5-V and 1.5-V output, 2.2% +/- 1.9% and 2.0% +/- 2.0%, respectively. The frequency of back-up pulses significantly increased at 1.0-V output to 5.8% +/- 6.4% (P <.05). Back-up pulses >5% of the time between the 2 follow-ups were observed in no patient at 2.5 V, in 1 patient at 1.5 V, and in 5 patients at 1.0 V. At the randomization to the 1.0-V output, 6 patients had pacing thresholds of 0.5 V or less, and 6 patients had pacing thresholds >0.5 V. The frequency of back-up pulses in the 2 groups was not significantly different, 6.4% +/- 8.6% and 5.7% +/- 2.6%. The frequency of back-up pulses was significantly higher at 1.0-V output than at 1.5-V and 2.5-V output. This also applied to patients with pacing thresholds of < or =0.5 V. Fixed low outputs seem not to be absolutely safe between 2 follow-ups in patients who are dependent on a pacemaker, even when the output has a 100% voltage safety margin above the pacing threshold. When patients with pacemakers programmed to a low ventricular output have symptoms of ineffective pacing, an intermittent increase of the pacing threshold should be carefully ruled out.

Reducing Backups by Utilizing DMF

NASA Technical Reports Server (NTRS)

Cardo, Nicholas P.; Woodrow, Thomas (Technical Monitor)

1994-01-01

Although a filesystem may be migratable, for a period of time the data blocks are on disk only. When performing system dumps, these data blocks are backed up to tape. If the data blocks are offline or dual resident, then only the inode is backed up. If all online files are made dual resident prior to performing system dumps, the dump time and the amount of resources required can be significantly reduced. The High Speed Processors group at the Numerical Aerodynamics Simulation (NAS) Facility at NASA Ames Research Center developed a tool to make all online files dual resident. The result is that a file whose data blocks are on DMF tape and still assigned to the original inode. Our 150GB filesystem used to take 8 to 12 hours to backup and used 50 to 60 tapes. Now the backup is typically under 10 tapes and completes in under 2 hours. This paper discusses this new tool and advantages gained by using it.

X-wing fly-by-wire vehicle management system

NASA Technical Reports Server (NTRS)

Fischer, Jr., William C. (Inventor)

1990-01-01

A complete, computer based, vehicle management system (VMS) for X-Wing aircraft using digital fly-by-wire technology controlling many subsystems and providing functions beyond the classical aircraft flight control system. The vehicle management system receives input signals from a multiplicity of sensors and provides commands to a large number of actuators controlling many subsystems. The VMS includes--segregating flight critical and mission critical factors and providing a greater level of back-up or redundancy for the former; centralizing the computation of functions utilized by several subsystems (e.g. air data, rotor speed, etc.); integrating the control of the flight control functions, the compressor control, the rotor conversion control, vibration alleviation by higher harmonic control, engine power anticipation and self-test, all in the same flight control computer (FCC) hardware units. The VMS uses equivalent redundancy techniques to attain quadruple equivalency levels; includes alternate modes of operation and recovery means to back-up any functions which fail; and uses back-up control software for software redundancy.

Tracer techniques for urine volume determination and urine collection and sampling back-up system

NASA Technical Reports Server (NTRS)

Ramirez, R. V.

1971-01-01

The feasibility, functionality, and overall accuracy of the use of lithium were investigated as a chemical tracer in urine for providing a means of indirect determination of total urine volume by the atomic absorption spectrophotometry method. Experiments were conducted to investigate the parameters of instrumentation, tracer concentration, mixing times, and methods for incorporating the tracer material in the urine collection bag, and to refine and optimize the urine tracer technique to comply with the Skylab scheme and operational parameters of + or - 2% of volume error and + or - 1% accuracy of amount of tracer added to each container. In addition, a back-up method for urine collection and sampling system was developed and evaluated. This back-up method incorporates the tracer technique for volume determination in event of failure of the primary urine collection and preservation system. One chemical preservative was selected and evaluated as a contingency chemical preservative for the storage of urine in event of failure of the urine cooling system.

Feasibility analysis of a hydrogen backup power system for Russian telecom market

NASA Astrophysics Data System (ADS)

Borzenko, V. I.; Dunikov, D. O.

2017-11-01

We performed feasibility analysis of 10 kW hydrogen backup power system (H2BS) consisting of a water electrolyzer, a metal hydride hydrogen storage and a fuel cell. Capital investments in H2BS are mostly determined by the costs of the PEM electrolyzer, the fuel cell and solid state hydrogen storage materials, for single unit or small series manufacture the cost of AB5-type intermetallic compound can reach 50% of total system cost. Today the capital investments in H2BS are 3 times higher than in conventional lead-acid system of the same capacity. Wide distribution of fuel cell hydrogen vehicles, development of hydrogen infrastructure, and mass production of hydrogen power systems will for sure lower capital investments in fuel cell backup power. Operational expenditures for H2BS is only 15% from the expenditures for lead acid systems, and after 4-5 years of exploitation the total cost of ownership will become lower than for batteries.

Traveling Abroad: Latest Yellow Fever Vaccine Update | Poster

Cancer.gov

Earlier this month, the U.S. Centers for Disease Control and Prevention (CDC) released its list of clinics that are administering the yellow fever vaccine Stamaril, which has been made available to address the total depletion of the United States’ primary yellow fever vaccine, YF-VAX. These clinics will provide the vaccine to individuals preparing for international travel,

Preclinical Development of TVAX: An Advanced Multiantigen Vaccine for Therapy and Prevention of Malignant Mesothelioma

DTIC Science & Technology

2017-09-01

immune responses. What opportunities for training and professional development has the project provided? A career development plan for myself, the...Martin R, Tassone R, Liu R, Terry F, Martin B, De Groot AS. iVAX: An integrated toolkit for the selection and optimization of antigens and the design of

Global Reference Atmosphere Model (GRAM)

NASA Technical Reports Server (NTRS)

Woodrum, A. W.

1989-01-01

GRAM series of four-dimensional atmospheric model validated by years of data. GRAM program, still available. More current are Gram 86, which includes atmospheric data from 1986 and runs on DEC VAX, and GRAM 88, which runs on IBM 3084. Program generates altitude profiles of atmospheric parameters along any simulated trajectory through atmosphere, and also useful for global circulation and diffusion studies.

Flexible Animation Computer Program

NASA Technical Reports Server (NTRS)

Stallcup, Scott S.

1990-01-01

FLEXAN (Flexible Animation), computer program animating structural dynamics on Evans and Sutherland PS300-series graphics workstation with VAX/VMS host computer. Typical application is animation of spacecraft undergoing structural stresses caused by thermal and vibrational effects. Displays distortions in shape of spacecraft. Program displays single natural mode of vibration, mode history, or any general deformation of flexible structure. Written in FORTRAN 77.

Technical Report for Water Circulation Pumping System for Trihalomethanes (THMs)

DOE Office of Scientific and Technical Information (OSTI.GOV)

Bellah, W.

2015-06-08

The TSWWS was added as an active source of supply to the permit (No. 03-10-13P-003) in 2010, but has never been used due to the potential for formation of trihalomethanes (THMs) in the distribution system. THMs are formed as a by-product when chlorine is used to disinfect water for drinking. THMs are a group of chemicals generally referred to as disinfection by-products (DBPs). THMs result from the reaction of chlorine with organic matter that is present in the water. Some of the THMs are volatile and may easily vaporize into the air. This fact forms the basis of the designmore » of the system discussed in this technical report. In addition, the design is based on the results of a study that has shown success using aeration as a means to reduce TTHMs to within allowable concentration levels with turn-over times as long as ten days. The Primary Drinking Water Standards of Regulated Contaminants Maximum Contaminant Level (MCL) for TTHMs is 80 parts per billion (ppb). No other changes to the existing drinking water distribution system and chlorination operations are anticipated before switching to the TSWWS as the primary drinking water source. The two groundwater wells (Wells 20 and 18) which are currently the primary and backup water sources for the system would be maintained for use as backup supply. In the future, one of the wells may be removed from the system. A permit amendment would be filed at that time if this modification was deemed appropriate.« less

Data analysis of P sub T/P sub S noseboom probe testing on F100 engine P680072 at NASA Lewis Research Center

NASA Technical Reports Server (NTRS)

Foote, C. H.

1980-01-01

Results from the altitude testing of a P sub T/P sub S noseboom probe on the F100 engine are discused. The results are consistent with sea level test results. The F100 engine altitude test verified automatic downmatch with the engine pressure ratio control, and backup control inlet case static pressure demonstrated sufficient accuracy for backup control fuel flow scheduling. The production P6 probe measured Station 6 pressures accurately for both undistorted and distorted inlet airflows.

ISS Expedition 43 Crew Departure from Russia

NASA Image and Video Library

2015-03-16

NASA video file of ISS Expedition 43 crew departure from Russia on March 16, 2015 with crewmembers Scott Kelly, Gennady Padalka, and Mikhail Kornienko; and backupcrew Jeff Williams, Sergei Volkov and Alexie Ovchinin. Includes footage of crew and backup crew as the meet outside the Gagarin Cosmonaut Training Center (GCTC); ISS Expedition 42 crewmembers Elena Serova and Alexander Samokutyaev as they exits the GCTC; crew and backup crew with family, friends and officials as they walk to park, pose for photographs and offers short remarks; and finally the crew as they are leaving by bus.

Engines-only flight control system

NASA Technical Reports Server (NTRS)

Burcham, Frank W. (Inventor); Gilyard, Glenn B (Inventor); Conley, Joseph L. (Inventor); Stewart, James F. (Inventor); Fullerton, Charles G. (Inventor)

1994-01-01

A backup flight control system for controlling the flightpath of a multi-engine airplane using the main drive engines is introduced. The backup flight control system comprises an input device for generating a control command indicative of a desired flightpath, a feedback sensor for generating a feedback signal indicative of at least one of pitch rate, pitch attitude, roll rate and roll attitude, and a control device for changing the output power of at least one of the main drive engines on each side of the airplane in response to the control command and the feedback signal.

Business Case for Fuel Cells 2016

DOE Office of Scientific and Technical Information (OSTI.GOV)

Curtin, Sandra; Gangi, Jennifer; Benjamin, Thomas G.

The report provides an overview of recent private sector fuel cell installations at U.S. businesses as of December 31, 2016. This list is by no means exhaustive. Over the past few decades, hundreds of thousands of fuel cells have been installed around the world, for primary or backup power, as well as in various other applications including portable and emergency backup power. Fuel cells have also been deployed in other applications such as heat and electricity for homes and apartments, material handling, passenger vehicles, buses, and remote, off-grid sites.

jsc2012e239100

NASA Image and Video Library

2012-11-29

At the Gagarin Cosmonaut Training Center in Star City, Russia, backup Expedition 34/35 crewmember Karen Nyberg of NASA answers a question from a reporter during a news conference Nov. 29, 2012. Nyberg, Soyuz Commander Fyodor Yurchikhin (center) and Luca Parmitano of the European Space Agency (right are the backups to prime crewmembers Tom Marshburn of NASA, Russian cosmonaut Roman Romanenko and Chris Hadfield of the Canadian Space Agency who are training for launch Dec. 19 to the International Space Station in their Soyuz TMA-07M spacecraft from the Baikonur Cosmodrome in Kazakhstan. NASA/Stephanie Stoll

jsc2018e048511

NASA Image and Video Library

2018-05-14

jsc2018e048511 - Expedition 56 backup crewmember David Saint-Jacques of the Canadian Space Agency poses for pictures in the Kremlin gardens in Moscow May 14 as part of traditional pre-launch activities. Saint-Jacques is serving as a backup to the prime crew, Serena Aunon-Chancellor of NASA, Sergey Prokopyev of Roscosmos and Alexander Gerst of the European Space Agency, who will launch June 6 from the Baikonur Cosmodrome in Kazakhstan on the Soyuz MS-09 spacecraft for a six month mission on the International Space Station...NASA/Elizabeth Weissinger.

STS-55 backup Payload Specialist Thiele with technician in JSC's WETF

NASA Technical Reports Server (NTRS)

1992-01-01

STS-55 Columbia, Orbiter Vehicle (OV) 102, backup German Payload Specialist Dr. P. Gerhard Thiele, wearing launch and entry suit (LES), launch and entry helmet (LEH), and parachute, seated on the poolside waits his turn to participate in launch emergency egress (bailout) exercises. The session, held in JSC's Weightless Environment Training Facility (WETF) Bldg 29, used the facility's 25-foot deep pool to simulate the ocean as Thiele and other crewmembers practiced water bailout procedures. Thiele represents the DLR for the upcoming Spacelab Deutsche 2 (SL-D2) mission.

Flight evaluation of an engine static pressure noseprobe in an F-15 airplane

NASA Technical Reports Server (NTRS)

Foote, C. H.; Jaekel, R. F.

1981-01-01

The flight testing of an inlet static pressure probe and instrumented inlet case produced results consistent with sea-level and altitude stand testing. The F-15 flight test verified the basic relationship of total to static pressure ratio versus corrected airflow and automatic distortion downmatch with the engine pressure ratio control mode. Additionally, the backup control inlet case statics demonstrated sufficient accuracy for backup control fuel flow scheduling, and the station 6 manifolded production probe was in agreement with the flight test station 6 tota pressure probes.

Inheritance of high levels of resistance to common bacterial blight caused by Xanthomonas Axonopodis pv. Phaseoli in common bean (Phaseolus vulgaris L.)

USDA-ARS?s Scientific Manuscript database

Common bacterial blight caused by the pathogen Xanthomonas axonopodis pv. phaseoli (Xap) is an important biotic factor limiting common bean (Phaseolus vulgaris L.) production. A few interspecific bean breeding lines such as VAX 6 exhibit a high level of resistance to a wide range of Xap strains repr...

Expert System for Automated Design Synthesis

NASA Technical Reports Server (NTRS)

Rogers, James L., Jr.; Barthelemy, Jean-Francois M.

1987-01-01

Expert-system computer program EXADS developed to aid users of Automated Design Synthesis (ADS) general-purpose optimization program. EXADS aids engineer in determining best combination based on knowledge of specific problem and expert knowledge stored in knowledge base. Available in two interactive machine versions. IBM PC version (LAR-13687) written in IQ-LISP. DEC VAX version (LAR-13688) written in Franz-LISP.

Computer simulation of FT-NMR multiple pulse experiment

NASA Astrophysics Data System (ADS)

Allouche, A.; Pouzard, G.

1989-04-01

Using the product operator formalism in its real form, SIMULDENS expands the density matrix of a scalar coupled nuclear spin system and simulates analytically a large variety of FT-NMR multiple pulse experiments. The observable transverse magnetizations are stored and can be combined to represent signal accumulation. The programming language is VAX PASCAL, but a MacIntosh Turbo Pascal Version is also available.

Engineering graphics data entry for space station data base

NASA Technical Reports Server (NTRS)

Lacovara, R. C.

1986-01-01

The entry of graphical engineering data into the Space Station Data Base was examined. Discussed were: representation of graphics objects; representation of connectivity data; graphics capture hardware; graphics display hardware; site-wide distribution of graphics, and consolidation of tools and hardware. A fundamental assumption was that existing equipment such as IBM based graphics capture software and VAX networked facilities would be exploited. Defensible conclusions reached after study and simulations of use of these systems at the engineering level are: (1) existing IBM based graphics capture software is an adequate and economical means of entry of schematic and block diagram data for present and anticipated electronic systems for Space Station; (2) connectivity data from the aforementioned system may be incorporated into the envisioned Space Station Data Base with modest effort; (3) graphics and connectivity data captured on the IBM based system may be exported to the VAX network in a simple and direct fashion; (4) graphics data may be displayed site-wide on VT-125 terminals and lookalikes; (5) graphics hard-copy may be produced site-wide on various dot-matrix printers; and (6) the system may provide integrated engineering services at both the engineering and engineering management level.