Heavy-to-light scalar form factors from Muskhelishvili-Omnès dispersion relations

NASA Astrophysics Data System (ADS)

Yao, D.-L.; Fernandez-Soler, P.; Albaladejo, M.; Guo, F.-K.; Nieves, J.

2018-04-01

By solving the Muskhelishvili-Omnès integral equations, the scalar form factors of the semileptonic heavy meson decays D→ π \\bar{ℓ }ν _ℓ , D→ {\\bar{K}} \\bar{ℓ }ν _ℓ , {\\bar{B}}→ π ℓ \\bar{ν }_ℓ and {\\bar{B}}_s→ K ℓ \\bar{ν }_ℓ are simultaneously studied. As input, we employ unitarized heavy meson-Goldstone boson chiral coupled-channel amplitudes for the energy regions not far from thresholds, while, at high energies, adequate asymptotic conditions are imposed. The scalar form factors are expressed in terms of Omnès matrices multiplied by vector polynomials, which contain some undetermined dispersive subtraction constants. We make use of heavy quark and chiral symmetries to constrain these constants, which are fitted to lattice QCD results both in the charm and the bottom sectors, and in this latter sector to the light-cone sum rule predictions close to q^2=0 as well. We find a good simultaneous description of the scalar form factors for the four semileptonic decay reactions. From this combined fit, and taking advantage that scalar and vector form factors are equal at q^2=0, we obtain |V_{cd}|=0.244± 0.022, |V_{cs}|=0.945± 0.041 and |V_{ub}|=(4.3± 0.7)× 10^{-3} for the involved Cabibbo-Kobayashi-Maskawa (CKM) matrix elements. In addition, we predict the following vector form factors at q^2=0: |f_+^{D→ η }(0)|=0.01± 0.05, |f_+^{D_s→ K}(0)|=0.50 ± 0.08, |f_+^{D_s→ η }(0)|=0.73± 0.03 and |f_+^{{\\bar{B}}→ η }(0)|=0.82 ± 0.08, which might serve as alternatives to determine the CKM elements when experimental measurements of the corresponding differential decay rates become available. Finally, we predict the different form factors above the q^2-regions accessible in the semileptonic decays, up to moderate energies amenable to be described using the unitarized coupled-channel chiral approach.

Combined search for anomalous pseudoscalar HVV couplings in VH (H → $$b\\bar{b}$$) production and H → VV decay

DOE PAGES

Khachatryan, Vardan

2016-06-07

Here, a search for anomalous pseudoscalar couplings of the Higgs boson H to electroweak vector bosons V (= W or Z) in a sample of proton-proton collision events corresponding to an integrated luminosity of 18.9 fbmore » $$^{-1}$$ at a center-of-mass energy of 8 TeV is presented. Events consistent with the topology of associated VH production, where the Higgs boson decays to a pair of bottom quarks and the vector boson decays leptonically, are analyzed. The consistency of data with a potential pseudoscalar contribution to the HVV interaction, expressed by the effective pseudoscalar cross section fractions $$f_{a_3}$$, is assessed by means of profile likelihood scans. Results are given for the VH channels alone and for a combined analysis of the VH and previously published H $$\\rightarrow$$ VV channels. Assuming the standard model ratio of the coupling strengths of the Higgs boson to top and bottom quarks, $$ f_{a_3}^{\\mathrm{ZZ}}>0.0034$$ is excluded at 95% confidence level in the combination.« less

Experimental Validation of a Coupled Fluid-Multibody Dynamics Model for Tanker Trucks

DTIC Science & Technology

2007-11-08

order to accurately predict the dynamic response of tanker trucks, the model must accurately account for the following effects : • Incompressible...computational code which uses a time- accurate explicit solution procedure is used to solve both the solid and fluid equations of motion. Many commercial...position vector, τ is the deviatoric stress tensor, D is the rate of deformation tensor, f r is the body force vector, r is the artificial

Description of two new plasmids isolated from Francisella philomiragia strains and construction of shuttle vectors for the study of Francisella tularensis.

PubMed

Le Pihive, E; Blaha, D; Chenavas, S; Thibault, F; Vidal, D; Valade, E

2009-11-01

Francisella tularensis is the causative agent of tularemia, a zoonotic disease often transmitted to humans by infected animals. The lack of useful specific genetic tools has long hampered the study of F. tularensis subspecies. We identified and characterized two new plasmids, pF242 and pF243, isolated from Francisella philomiragia strains ATCC 25016 and ATCC 25017, respectively. Sequence analysis revealed that pF242 and pF243 are closely related to pC194 and pFNL10 plasmids, respectively. Two generations of pF242- and pF243-based shuttle vectors, harboring several antibiotic resistance markers, were developed. We used the first generation to compare transformation efficiencies in two virulent F. tularensis subspecies. We found that electroporation was more efficient than cryotransformation: almost all vectors tested were successfully introduced by electroporation into Francisella strains with a high level of efficiency. The second generation of shuttle vectors, containing a multiple cloning site and/or gfp gene downstream of Francisella groES promotor, was used for GFP production in F. tularensis. The development of new shuttle vectors offers new perspectives in the genetic manipulation of F. tularensis, helping to elucidate the mechanisms underlying its virulence.

Diffusible signal factor-repressed extracellular traits enable attachment of Xylella fastidiosa to insect vectors and transmission.

PubMed

Baccari, Clelia; Killiny, Nabil; Ionescu, Michael; Almeida, Rodrigo P P; Lindow, Steven E

2014-01-01

The hypothesis that a wild-type strain of Xylella fastidiosa would restore the ability of rpfF mutants blocked in diffusible signal factor production to be transmitted to new grape plants by the sharpshooter vector Graphocephala atropunctata was tested. While the rpfF mutant was very poorly transmitted by vectors irrespective of whether they had also fed on plants infected with the wild-type strain, wild-type strains were not efficiently transmitted if vectors had fed on plants infected with the rpfF mutant. About 100-fewer cells of a wild-type strain attached to wings of a vector when suspended in xylem sap from plants infected with an rpfF mutant than in sap from uninfected grapes. The frequency of transmission of cells suspended in sap from plants that were infected by the rpfF mutant was also reduced over threefold. Wild-type cells suspended in a culture supernatant of an rpfF mutant also exhibited 10-fold less adherence to wings than when suspended in uninoculated culture media. A factor released into the xylem by rpfF mutants, and to a lesser extent by the wild-type strain, thus inhibits their attachment to, and thus transmission by, sharpshooter vectors and may also enable them to move more readily through host plants.

New limit on possible long-range parity-odd interactions of the neutron from neutron-spin rotation in liquid 4He.

PubMed

Yan, H; Snow, W M

2013-02-22

Various theories beyond the standard model predict new particles with masses in the sub-eV range with very weak couplings to ordinary matter. A parity-odd interaction between polarized nucleons and unpolarized matter proportional to g(V)g(A)s · p is one such possibility, where s[over →] and p[over →] are the spin and the momentum of the polarized nucleon, and g(V) and g(A) are the vector and axial vector couplings of an interaction induced by the exchange of a new light vector boson. We report a new experimental upper bound on such possible long-range parity-odd interactions of the neutron with nucleons and electrons from a recent search for parity violation in neutron spin rotation in liquid ^{4}He. Our constraint on the product of vector and axial vector couplings of a possible new light vector boson is g(V) g(A)(n) ≤ 10(-32) for an interaction range of 1 m. This upper bound is more than 7 orders of magnitude more stringent than the existing laboratory constraints for interaction ranges below 1 m, corresponding to a broad range of vector boson masses above 10(-6) eV. More sensitive searches for a g(V) g(A)(n) coupling could be performed using neutron spin rotation measurements in heavy nuclei or through analysis of experiments conducted to search for nucleon-nucleon weak interactions and nuclear anapole moments.

Improved muscle-derived expression of human coagulation factor IX from a skeletal actin/CMV hybrid enhancer/promoter.

PubMed

Hagstrom, J N; Couto, L B; Scallan, C; Burton, M; McCleland, M L; Fields, P A; Arruda, V R; Herzog, R W; High, K A

2000-04-15

Hemophilia B is caused by the absence of functional coagulation factor IX (F.IX) and represents an important model for treatment of genetic diseases by gene therapy. Recent studies have shown that intramuscular injection of an adeno-associated viral (AAV) vector into mice and hemophilia B dogs results in vector dose-dependent, long-term expression of biologically active F.IX at therapeutic levels. In this study, we demonstrate that levels of expression of approximately 300 ng/mL (6% of normal human F.IX levels) can be reached by intramuscular injection of mice using a 2- to 4-fold lower vector dose (1 x 10(11) vector genomes/mouse, injected into 4 intramuscular sites) than previously described. This was accomplished through the use of an improved expression cassette that uses the cytomegalovirus (CMV) immediate early enhancer/promoter in combination with a 1.2-kilobase portion of human skeletal actin promoter. These results correlated with enhanced levels of F.IX transcript and secreted F.IX protein in transduced murine C2C12 myotubes. Systemic F.IX expression from constructs containing the CMV enhancer/promoter alone was 120 to 200 ng/mL in mice injected with 1 x 10(11) vector genomes. Muscle-specific promoters performed poorly for F.IX transgene expression in vitro and in vivo. However, the incorporation of a sequence from the alpha-skeletal actin promoter containing at least 1 muscle-specific enhancer and 1 enhancer-like element further improved muscle-derived expression of F.IX from a CMV enhancer/promoter-driven expression cassette over previously published results. These findings will allow the design of a clinical protocol for therapeutic levels of F.IX expression with lower vector doses, thus enhancing efficacy and safety of the protocol. (Blood. 2000;95:2536-2542)

Influence of vector dose on factor IX-specific T and B cell responses in muscle-directed gene therapy.

PubMed

Herzog, Roland W; Fields, Paul A; Arruda, Valder R; Brubaker, Jeff O; Armstrong, Elina; McClintock, Darryl; Bellinger, Dwight A; Couto, Linda B; Nichols, Timothy C; High, Katherine A

2002-07-20

Intramuscular injection of an adeno-associated virus (AAV) vector has resulted in vector dose-dependent, stable expression of canine factor IX (cF.IX) in hemophilia B dogs with an F.IX missense mutation (Herzog et al., Nat. Med. 1999;5:56-63). The use of a species-specific transgene allowed us to study risks and characteristics of antibody formation against the therapeutic transgene product. We analyzed seven dogs that had been injected at a single time point at multiple intramuscular sites with varying vector doses (dose per kilogram, dose per animal, dose per site). Comparison of individual animals suggests an increased likelihood of inhibitory anti-cF.IX (inhibitor) development with increased vector doses, with dose per site showing the strongest correlation with the risk of inhibitor formation. In six of seven animals, such immune responses were either absent or transient, and therefore did not prevent sustained systemic expression of cF.IX. Transient inhibitory/neutralizing anti-cF.IX responses occurred at vector doses of 2 x 10(12)/site, whereas a 6-fold higher dose resulted in a longer lasting, higher titer inhibitor. Anti-cF.IX was efficiently blocked in an eighth animal that was injected with a high vector dose per site, but in addition received transient immune suppression. Inhibitor formation was characterized by synthesis of two IgG subclasses and in vitro proliferation of lymphocytes to cF.IX antigen, indicating a helper T cell-dependent mechanism. Anti-cF.IX formation is likely influenced by the extent of local antigen presentation and may be avoided by limited vector doses or by transient immune modulation.

K π vector form factor, dispersive constraints and τ→ ν τ K π decays

NASA Astrophysics Data System (ADS)

Boito, Diogo R.; Escribano, Rafel; Jamin, Matthias

2009-02-01

Recent experimental data for the differential decay distribution of the decay τ -→ ν τ K S π - by the Belle collaboration are described by a theoretical model which is composed of the contributing vector and scalar form factors F {+/ K π }( s) and F {0/ K π }( s). Both form factors are constructed such that they fulfil constraints posed by analyticity and unitarity. A good description of the experimental measurement is achieved by incorporating two vector resonances and working with a three-times-subtracted dispersion relation in order to suppress higher-energy contributions. The resonance parameters of the charged K *(892) meson, defined as the pole of F {+/ K π }( s) in the complex s-plane, can be extracted, with the result M_{K^{*}}=892.0± 0.9 MeV and \\varGamma_{K^{*}}=46.2± 0.4 MeV . Finally, employing a three-times-subtracted dispersion relation allows one to determine the slope and curvature parameters λ'+=(24.7±0.8)×10-3 and λ″+=(12.0±0.2)×10-4 of the vector form factor F {+/ K π }( s) directly from the data.

Monte Carlo Simulation of Seismic Location Errors for Moving Vehicles

DTIC Science & Technology

2001-10-04

Smart Weapons Test Range 9/14/200 Four wheel Drive; File 14, Aberdeen, MD, Site 1 June 11, 1996, 10c runs, Piston Tank ; 10:18 34:42 53:55 58:64...72:79 92:97 105:118 % file vector Ft. Greely, AK, Site 1 1/27/1997, , Piston Tank ; 34:42 53:64 % file vector Ft. Greely, AK, Site 2...Dec 11, 1997 ; File 56, , Piston Tank Aberdeen, MD, Site 2 10/28/97 File84; File 56 200 400 600 800 1000 1200 -160 -150 -140 -130 -120 fL fH

Mean-field theory for multipole ordering in f-electron systems on the basis of a j-j coupling scheme

NASA Astrophysics Data System (ADS)

Yamamura, Ryosuke; Hotta, Takashi

2018-05-01

We develop a microscopic theory for multipole ordering, applicable to the system with plural numbers of f electrons per ion, from an itinerant picture on the basis of a j-j coupling scheme. For the purpose, by introducing the Γ8 Hubbard Hamiltonian as the minimum model to discuss the multipole ordering in f-electron systems, we describe the mean-field approximation in terms of the multipole operators. For the case of n = 2 , where n denotes the average f-electron number per ion, we analyze the model on a simple cubic lattice to obtain the multipole phase diagram. In particular, we find the order of non-Kramers Γ3 quadrupoles, O20 and O22 , with different ordering vectors. We attempt to explain the phase diagram from the discussion on the interaction energy.

Anisotropic power-law inflation for a conformal-violating Maxwell model

NASA Astrophysics Data System (ADS)

Do, Tuan Q.; Kao, W. F.

2018-05-01

A set of power-law solutions of a conformal-violating Maxwell model with a non-standard scalar-vector coupling will be shown in this paper. In particular, we are interested in a coupling term of the form X^{2n} F^{μ ν }F_{μ ν } with X denoting the kinetic term of the scalar field. Stability analysis indicates that the new set of anisotropic power-law solutions is unstable during the inflationary phase. The result is consistent with the cosmic no-hair conjecture. We show, however, that a set of stable slowly expanding solutions does exist for a small range of parameters λ and n. Hence a small anisotropy can survive during the slowly expanding phase.

Black hole perturbations in vector-tensor theories: the odd-mode analysis

NASA Astrophysics Data System (ADS)

Kase, Ryotaro; Minamitsuji, Masato; Tsujikawa, Shinji; Zhang, Ying-li

2018-02-01

In generalized Proca theories with vector-field derivative couplings, a bunch of hairy black hole solutions have been derived on a static and spherically symmetric background. In this paper, we formulate the odd-parity black hole perturbations in generalized Proca theories by expanding the corresponding action up to second order and investigate whether or not black holes with vector hair suffer ghost or Laplacian instabilities. We show that the models with cubic couplings G3(X), where X=‑AμAμ/2 with a vector field Aμ, do not provide any additional stability condition as in General Relativity. On the other hand, the exact charged stealth Schwarzschild solution with a nonvanishing longitudinal vector component A1, which originates from the coupling to the Einstein tensor GμνAμ Aν equivalent to the quartic coupling G4(X) containing a linear function of X, is unstable in the vicinity of the event horizon. The same instability problem also persists for hairy black holes arising from general quartic power-law couplings G4(X) ⊃ β4 Xn with the nonvanishing A1, while the other branch with A1=0 can be consistent with conditions for the absence of ghost and Laplacian instabilities. We also discuss the case of other exact and numerical black hole solutions associated with intrinsic vector-field derivative couplings and show that there exists a wide range of parameter spaces in which the solutions suffer neither ghost nor Laplacian instabilities against odd-parity perturbations.

Experimental investigation of spin-orbit coupling in n-type PbTe quantum wells

DOE Office of Scientific and Technical Information (OSTI.GOV)

Peres, M. L.; Monteiro, H. S.; Castro, S. de

2014-03-07

The spin-orbit coupling is studied experimentally in two PbTe quantum wells by means of weak antilocalization effect. Using the Hikami-Larkin-Nagaoka model through a computational global optimization procedure, we extracted the spin-orbit and inelastic scattering times and estimated the strength of the zero field spin-splitting energy Δ{sub so}. The values of Δ{sub so} are linearly dependent on the Fermi wave vector (k{sub F}) confirming theoretical predictions of the existence of large spin-orbit coupling in IV-VI quantum wells originated from pure Rashba effect.

Evaluation of the discrete vortex wake cross flow model using vector computers. Part 1: Theory and application

NASA Technical Reports Server (NTRS)

1979-01-01

The current program had the objective to modify a discrete vortex wake method to efficiently compute the aerodynamic forces and moments on high fineness ratio bodies (f approximately 10.0). The approach is to increase computational efficiency by structuring the program to take advantage of new computer vector software and by developing new algorithms when vector software can not efficiently be used. An efficient program was written and substantial savings achieved. Several test cases were run for fineness ratios up to f = 16.0 and angles of attack up to 50 degrees.

Higgs mass and unified gauge coupling in the NMSSM with vector matter

DOE PAGES

Barbieri, Riccardo; Buttazzo, Dario; Hall, Lawrence J.; ...

2016-07-13

Here, we consider the NMSSM extended to include one vector-like family of quarks and leptons. If (some of) these vector-like matter particles, as the Higgs doublets, have Yukawa couplings to the singlet S that exceed unity at about the same scale Λ ≲ 10 3 TeV, this gives the order 40% enhancement of the tree level Higgs boson mass required in the MSSM to reach 125 GeV. It is conceivable that the Yukawa couplings to the singlet S, although naively blowing up close to Λ, will not spoil gauge coupling unification. In such a case the unified coupling α Xmore » could be interestingly led to a value not far from unity, thus providing a possible explanation for the number of generations. Also, the characteristic signal is an enhanced resonant production of neutral spin zero particles at LHC, that could even explain the putative diphoton resonance hinted by the recent LHC data at 750 GeV.« less

Closed-form solutions of the Wheeler-DeWitt equation in a scalar-vector field cosmological model by Lie symmetries

NASA Astrophysics Data System (ADS)

Paliathanasis, Andronikos; Vakili, Babak

2016-01-01

We apply as selection rule to determine the unknown functions of a cosmological model the existence of Lie point symmetries for the Wheeler-DeWitt equation of quantum gravity. Our cosmological setting consists of a flat Friedmann-Robertson-Walker metric having the scale factor a( t), a scalar field with potential function V(φ ) minimally coupled to gravity and a vector field of its kinetic energy is coupled with the scalar field by a coupling function f(φ ). Then, the Lie symmetries of this dynamical system are investigated by utilizing the behavior of the corresponding minisuperspace under the infinitesimal generator of the desired symmetries. It is shown that by applying the Lie symmetry condition the form of the coupling function and also the scalar field potential function may be explicitly determined so that we are able to solve the Wheeler-DeWitt equation. Finally, we show how we can use the Lie symmetries in order to construct conservation laws and exact solutions for the field equations.

f(R) gravity on non-linear scales: the post-Friedmann expansion and the vector potential

DOE Office of Scientific and Technical Information (OSTI.GOV)

Thomas, D.B.; Bruni, M.; Koyama, K.

2015-07-01

Many modified gravity theories are under consideration in cosmology as the source of the accelerated expansion of the universe and linear perturbation theory, valid on the largest scales, has been examined in many of these models. However, smaller non-linear scales offer a richer phenomenology with which to constrain modified gravity theories. Here, we consider the Hu-Sawicki form of f(R) gravity and apply the post-Friedmann approach to derive the leading order equations for non-linear scales, i.e. the equations valid in the Newtonian-like regime. We reproduce the standard equations for the scalar field, gravitational slip and the modified Poisson equation in amore » coherent framework. In addition, we derive the equation for the leading order correction to the Newtonian regime, the vector potential. We measure this vector potential from f(R) N-body simulations at redshift zero and one, for two values of the f{sub R{sub 0}} parameter. We find that the vector potential at redshift zero in f(R) gravity can be close to 50% larger than in GR on small scales for |f{sub R{sub 0}}|=1.289 × 10{sup −5}, although this is less for larger scales, earlier times and smaller values of the f{sub R{sub 0}} parameter. Similarly to in GR, the small amplitude of this vector potential suggests that the Newtonian approximation is highly accurate for f(R) gravity, and also that the non-linear cosmological behaviour of f(R) gravity can be completely described by just the scalar potentials and the f(R) field.« less

Baculovirus vectors expressing F proteins in combination with virus-induced signaling adaptor (VISA) molecules confer protection against respiratory syncytial virus infection.

PubMed

Zhang, Yuan; Qiao, Lei; Hu, Xiao; Zhao, Kang; Zhang, Yanwen; Chai, Feng; Pan, Zishu

2016-01-04

Baculovirus has been exploited for use as a novel vaccine vector. To investigate the feasibility and efficacy of recombinant baculoviruses (rBVs) expressing respiratory syncytial virus (RSV) fusion (F) proteins, four constructs (Bac-tF/64, Bac-CF, Bac-CF/tF64 and Bac-CF/tF64-VISA) were generated. Bac-tF64 displays the F ectodomain (tF) on the envelope of rBVs, whereas Bac-CF expresses full-length F protein in transduced mammalian cells. Bac-CF/tF64 not only displays tF on the envelope but also expresses F in cells. Bac-CF/tF64-VISA comprises Bac-CF/tF64 harboring the virus-induced signaling adaptor (VISA) gene. After administration to BALB/c mice, all four vectors elicited RSV neutralizing antibody (Ab), systemic Ab (IgG, IgG1, and IgG2a), and cytokine responses. Compared with Bac-tF64, mice inoculated with Bac-CF and Bac-CF/tF64 exhibited an increased mixed Th1/Th2 cytokine response, increased ratios of IgG2a/IgG1 antibody responses, and reduced immunopathology upon RSV challenge. Intriguingly, co-expression of VISA reduced Th2 cytokine (IL-4, IL-5, and IL-10) production induced by Bac-CF/tF64, thus relieving lung pathology upon a subsequent RSV challenge. Our results indicated that the Bac-CF/tF64 vector incorporated with the VISA molecule may provide an effective vaccine strategy for protection against RSV. Copyright © 2015 Elsevier Ltd. All rights reserved.

Multiple image encryption scheme based on pixel exchange operation and vector decomposition

NASA Astrophysics Data System (ADS)

Xiong, Y.; Quan, C.; Tay, C. J.

2018-02-01

We propose a new multiple image encryption scheme based on a pixel exchange operation and a basic vector decomposition in Fourier domain. In this algorithm, original images are imported via a pixel exchange operator, from which scrambled images and pixel position matrices are obtained. Scrambled images encrypted into phase information are imported using the proposed algorithm and phase keys are obtained from the difference between scrambled images and synthesized vectors in a charge-coupled device (CCD) plane. The final synthesized vector is used as an input in a random phase encoding (DRPE) scheme. In the proposed encryption scheme, pixel position matrices and phase keys serve as additional private keys to enhance the security of the cryptosystem which is based on a 4-f system. Numerical simulations are presented to demonstrate the feasibility and robustness of the proposed encryption scheme.

Prostate Cancer Skeletal Metastases: Pathobiology and Interventions

DTIC Science & Technology

2005-02-01

promoter-reporter vectors (Months 7-10). ii. Create and characterize activity of 50 bp deletion mutants based on information from Task Ibi (Months 11-14...iii. Clone into reporter vector and characterize activity of 50 bp fragment (from Task lbii) (Months 15-19). iv. Create and characterize activity of...Gowen M, Lazner F, Dodds R, Kapadia R, Feild J, Tavaria M, Bertoncello I, Drake F, Zavarselk S, Tellis I, Hertzog P, Debouck C, Kola I. Cathepsin K

Evolution from BCS superconductivity to Bose condensation: Calculation of the zero-temperature phase coherence length

DOE Office of Scientific and Technical Information (OSTI.GOV)

Pistolesi, F.; Strinati, G.C.

1996-06-01

We consider a fermionic system at zero temperature interacting through an effective nonretarded potential of the type introduced by Nozi{grave e}res and Schmitt-Rink, and calculate the {ital phase} coherence length {xi}{sub phase} (associated with the spatial fluctuations of the superconducting order parameter) by exploiting a functional-integral formulation for the correlation functions and the associated loop expansion. This formulation is especially suited to follow the evolution of the fermionic system from a BCS-type superconductor for weak coupling to a Bose-condensed system for strong coupling, since in the latter limit a {ital direct} mapping of the original fermionic system onto an effectivemore » system of bosons with a residual boson-boson interaction can be established. Explicit calculations are performed at the one-loop order. The phase coherence length {xi}{sub phase} is compared with the coherence length {xi}{sub pair} for two-electron correlation, which is relevant to distinguish the weak- ({ital k}{sub {ital F}}{xi}{sub pair}{gt}1) from the strong- ({ital k}{sub {ital F}}{xi}{sub pair}{lt}1) coupling limits ({ital k}{sub {ital F}} being the Fermi wave vector) {ital as} {ital well} {ital as} to follow the crossover in between. It is shown that {xi}{sub phase} coincides with {xi}{sub pair} down to {ital k}{sub {ital F}}{xi}{sub pair}{approx_equal}10, {xi}{sub pair} in turn coinciding with the Pippard coherence length. In the strong-coupling limit we find instead that {xi}{sub phase}{gt}{xi}{sub pair}, with {xi}{sub pair} coinciding with the radius of the bound-electron pair. From the mapping onto an effective system of bosons in the strong-coupling limit we further relate {xi}{sub pair} with the {open_quote}{open_quote}range{close_quote}{close_quote} of the residual boson-boson interaction, which is physically the only significant length associated with the dynamics of the bosonic system. {copyright} {ital 1996 The American Physical Society.}« less

Factor IX expression in skeletal muscle of a severe hemophilia B patient 10 years after AAV-mediated gene transfer.

PubMed

Buchlis, George; Podsakoff, Gregory M; Radu, Antonetta; Hawk, Sarah M; Flake, Alan W; Mingozzi, Federico; High, Katherine A

2012-03-29

In previous work we transferred a human factor IX-encoding adeno-associated viral vector (AAV) into skeletal muscle of men with severe hemophilia B. Biopsy of injected muscle up to 1 year after vector injection showed evidence of gene transfer by Southern blot and of protein expression by IHC and immunofluorescent staining. Although the procedure appeared safe, circulating F.IX levels remained subtherapeutic (< 1%). Recently, we obtained muscle tissue from a subject injected 10 years earlier who died of causes unrelated to gene transfer. Using Western blot, IHC, and immunofluorescent staining, we show persistent factor IX expression in injected muscle tissue. F.IX transcripts were detected in injected skeletal muscle using RT-PCR, and isolated whole genomic DNA tested positive for the presence of the transferred AAV vector sequence. This is the longest reported transgene expression to date from a parenterally administered AAV vector, with broad implications for the future of muscle-directed gene transfer.

Factor IX expression in skeletal muscle of a severe hemophilia B patient 10 years after AAV-mediated gene transfer

PubMed Central

Buchlis, George; Podsakoff, Gregory M.; Radu, Antonetta; Hawk, Sarah M.; Flake, Alan W.; Mingozzi, Federico

2012-01-01

In previous work we transferred a human factor IX–encoding adeno-associated viral vector (AAV) into skeletal muscle of men with severe hemophilia B. Biopsy of injected muscle up to 1 year after vector injection showed evidence of gene transfer by Southern blot and of protein expression by IHC and immunofluorescent staining. Although the procedure appeared safe, circulating F.IX levels remained subtherapeutic (< 1%). Recently, we obtained muscle tissue from a subject injected 10 years earlier who died of causes unrelated to gene transfer. Using Western blot, IHC, and immunofluorescent staining, we show persistent factor IX expression in injected muscle tissue. F.IX transcripts were detected in injected skeletal muscle using RT-PCR, and isolated whole genomic DNA tested positive for the presence of the transferred AAV vector sequence. This is the longest reported transgene expression to date from a parenterally administered AAV vector, with broad implications for the future of muscle-directed gene transfer. PMID:22271447

Fast and simultaneous determination of 1 H-1 H and 1 H-19 F scalar couplings in complex spin systems: Application of PSYCHE homonuclear broadband decoupling.

PubMed

Kakita, Veera Mohana Rao; Rachineni, Kavitha; Hosur, Ramakrishna V

2017-07-21

The present manuscript focuses on fast and simultaneous determination of 1 H- 1 H and 1 H- 19 F scalar couplings in fluorinated complex steroid molecules. Incorporation of broadband PSYCHE homonuclear decoupling in the indirect dimension of zero-quantum filtered diagonal experiments (F1-PSYCHE-DIAG) suppresses 1 H- 1 H scalar couplings; however, it retains 1 H- 19 F scalar couplings (along F1 dimension) for the 19 F coupled protons while preserving the pure-shift nature for 1 H resonances uncoupled to 19 F. In such cases, along the direct dimensions, 1 H- 1 H scalar coupling multiplets deconvolute and they appear as duplicated multiplets for the 19 F coupled protons, which facilitates unambiguous discrimination of 19 F coupled 1 H chemical sites from the others. Further, as an added advantage, data acquisition has been accelerated by invoking the known ideas of spectral aliasing in the F1-PSYCHE-DIAG scheme and experiments demand only ~10 min of spectrometer times. Copyright © 2017 John Wiley & Sons, Ltd.

Successful transduction of liver in hemophilia by AAV-Factor IX and limitations imposed by the host immune response.

PubMed

Manno, Catherine S; Pierce, Glenn F; Arruda, Valder R; Glader, Bertil; Ragni, Margaret; Rasko, John J; Rasko, John; Ozelo, Margareth C; Hoots, Keith; Blatt, Philip; Konkle, Barbara; Dake, Michael; Kaye, Robin; Razavi, Mahmood; Zajko, Albert; Zehnder, James; Rustagi, Pradip K; Nakai, Hiroyuki; Chew, Amy; Leonard, Debra; Wright, J Fraser; Lessard, Ruth R; Sommer, Jürg M; Tigges, Michael; Sabatino, Denise; Luk, Alvin; Jiang, Haiyan; Mingozzi, Federico; Couto, Linda; Ertl, Hildegund C; High, Katherine A; Kay, Mark A

2006-03-01

We have previously shown that a single portal vein infusion of a recombinant adeno-associated viral vector (rAAV) expressing canine Factor IX (F.IX) resulted in long-term expression of therapeutic levels of F.IX in dogs with severe hemophilia B. We carried out a phase 1/2 dose-escalation clinical study to extend this approach to humans with severe hemophilia B. rAAV-2 vector expressing human F.IX was infused through the hepatic artery into seven subjects. The data show that: (i) vector infusion at doses up to 2 x 10(12) vg/kg was not associated with acute or long-lasting toxicity; (ii) therapeutic levels of F.IX were achieved at the highest dose tested; (iii) duration of expression at therapeutic levels was limited to a period of approximately 8 weeks; (iv) a gradual decline in F.IX was accompanied by a transient asymptomatic elevation of liver transaminases that resolved without treatment. Further studies suggested that destruction of transduced hepatocytes by cell-mediated immunity targeting antigens of the AAV capsid caused both the decline in F.IX and the transient transaminitis. We conclude that rAAV-2 vectors can transduce human hepatocytes in vivo to result in therapeutically relevant levels of F.IX, but that future studies in humans may require immunomodulation to achieve long-term expression.

Laboratory Colonization of Anopheles (Nyssorhynchus) marajoara (Diptera: Culicidae) by Induced Copulation.

PubMed

Giglio, N F; Sousa-Lima, A S; Gallardo, A K R; Lima, J B P

2015-01-01

Malaria is a serious public health problem, the control of which involves actions directed against its vector, mosquitoes of the genus Anopheles Meigan, 1818. The study of insect biology, ecology, and behavior is simplified when these insects are maintained at the laboratory. However, many of the species are eurygamic and require induced mating. Females of Anopheles marajoara Galvão e Damasceno, 1942 were collected at Mazagão county, State of Amapá, Brazil. F1 eggs were obtained through forced oviposition and raised until mosquito emergence. Around 300 mosquitoes were maintained in each cage and were fed with a 10% sugar solution. Induced mating was made to obtain the other generations. Females had their spermathecae examined for the presence of sperm. The efficacy of coupling in each generation was evaluated. The viability of a sample of generations F5, F9, F12, and F14 was followed from larvae to adult. Two free mating attempts were done. The results demonstrate adaptation of An. marajoara to laboratory conditions over 21 generations, with viability rates temporally increasing. There was no evidence of adaptation to free mating. © The Author 2014. Published by Oxford University Press on behalf of the Entomological Society of America.For Permissions, please e-mail: journals.permissions@oup.com.

Effective gravitational couplings for cosmological perturbations in generalized Proca theories

NASA Astrophysics Data System (ADS)

De Felice, Antonio; Heisenberg, Lavinia; Kase, Ryotaro; Mukohyama, Shinji; Tsujikawa, Shinji; Zhang, Ying-li

2016-08-01

We consider the finite interactions of the generalized Proca theory including the sixth-order Lagrangian and derive the full linear perturbation equations of motion on the flat Friedmann-Lemaître-Robertson-Walker background in the presence of a matter perfect fluid. By construction, the propagating degrees of freedom (besides the matter perfect fluid) are two transverse vector perturbations, one longitudinal scalar, and two tensor polarizations. The Lagrangians associated with intrinsic vector modes neither affect the background equations of motion nor the second-order action of tensor perturbations, but they do give rise to nontrivial modifications to the no-ghost condition of vector perturbations and to the propagation speeds of vector and scalar perturbations. We derive the effective gravitational coupling Geff with matter density perturbations under a quasistatic approximation on scales deep inside the sound horizon. We find that the existence of intrinsic vector modes allows a possibility for reducing Geff. In fact, within the parameter space, Geff can be even smaller than the Newton gravitational constant G at the late cosmological epoch, with a peculiar phantom dark energy equation of state (without ghosts). The modifications to the slip parameter η and the evolution of the growth rate f σ8 are discussed as well. Thus, dark energy models in the framework of generalized Proca theories can be observationally distinguished from the Λ CDM model according to both cosmic growth and expansion history. Furthermore, we study the evolution of vector perturbations and show that outside the vector sound horizon the perturbations are nearly frozen and start to decay with oscillations after the horizon entry.

Duality-symmetric supersymmetric Yang-Mills theory in three dimensions

DOE Office of Scientific and Technical Information (OSTI.GOV)

Nishino, Hitoshi; Rajpoot, Subhash

We formulate a duality-symmetric N=1 supersymmetric Yang-Mills theory in three dimensions. Our field content is (A{sub {mu}}{sup I},{lambda}{sup I},{phi}{sup I}), where the index I is for the adjoint representation of an arbitrary gauge group G. Our Hodge duality symmetry is F{sub {mu}{nu}}{sup I}=+{epsilon}{sub {mu}{nu}}{sup {rho}D}{sub {rho}{phi}}{sup I}. Because of this relationship, the presence of two physical fields A{sub {mu}}{sup I} and {phi}{sup I} within the same N=1 supermultiplet poses no problem. We can couple this multiplet to another vector multiplet (C{sub {mu}}{sup I},{chi}{sup I};B{sub {mu}{nu}}{sup I}) with 1+1 physical degrees of freedom modulo dim G. Thanks to peculiar couplings andmore » supersymmetry, the usual problem with an extra vector field in a nontrivial representation does not arise in our system.« less

Simulation model of the F/A-18 high angle-of-attack research vehicle utilized for the design of advanced control laws

NASA Technical Reports Server (NTRS)

Strickland, Mark E.; Bundick, W. Thomas; Messina, Michael D.; Hoffler, Keith D.; Carzoo, Susan W.; Yeager, Jessie C.; Beissner, Fred L., Jr.

1996-01-01

The 'f18harv' six degree-of-freedom nonlinear batch simulation used to support research in advanced control laws and flight dynamics issues as part of NASA's High Alpha Technology Program is described in this report. This simulation models an F/A-18 airplane modified to incorporate a multi-axis thrust-vectoring system for augmented pitch and yaw control power and actuated forebody strakes for enhanced aerodynamic yaw control power. The modified configuration is known as the High Alpha Research Vehicle (HARV). The 'f18harv' simulation was an outgrowth of the 'f18bas' simulation which modeled the basic F/A-18 with a preliminary version of a thrust-vectoring system designed for the HARV. The preliminary version consisted of two thrust-vectoring vanes per engine nozzle compared with the three vanes per engine actually employed on the F/A-18 HARV. The modeled flight envelope is extensive in that the aerodynamic database covers an angle-of-attack range of -10 degrees to +90 degrees, sideslip range of -20 degrees to +20 degrees, a Mach Number range between 0.0 and 2.0, and an altitude range between 0 and 60,000 feet.

A Single-Dose Recombinant Parainfluenza Virus 5-Vectored Vaccine Expressing Respiratory Syncytial Virus (RSV) F or G Protein Protected Cotton Rats and African Green Monkeys from RSV Challenge.

PubMed

Wang, Dai; Phan, Shannon; DiStefano, Daniel J; Citron, Michael P; Callahan, Cheryl L; Indrawati, Lani; Dubey, Sheri A; Heidecker, Gwendolyn J; Govindarajan, Dhanasekaran; Liang, Xiaoping; He, Biao; Espeseth, Amy S

2017-06-01

Human respiratory syncytial virus (RSV) is a common cause of severe respiratory disease among infants, immunocompromised individuals, and the elderly. No licensed vaccine is currently available. In this study, we evaluated two parainfluenza virus 5 (PIV5)-vectored vaccines expressing RSV F (PIV5/F) or G (PIV5/G) protein in the cotton rat and African green monkey models for their replication, immunogenicity, and efficacy of protection against RSV challenge. Following a single intranasal inoculation, both animal species shed the vaccine viruses for a limited time but without noticeable clinical symptoms. In cotton rats, the vaccines elicited RSV F- or G-specific serum antibodies and conferred complete lung protection against RSV challenge at doses as low as 10 3 PFU. Neither vaccine produced the enhanced lung pathology observed in animals immunized with formalin-inactivated RSV. In African green monkeys, vaccine-induced serum and mucosal antibody responses were readily detected, as well. PIV5/F provided nearly complete protection against RSV infection in the upper and lower respiratory tract at a dose of 10 6 PFU of vaccine. At the same dose levels, PIV5/G was less efficacious. Both PIV5/F and PIV5/G were also able to boost neutralization titers in RSV-preexposed African green monkeys. Overall, our data indicated that PIV5/F is a promising RSV vaccine candidate. IMPORTANCE A safe and efficacious respiratory syncytial virus (RSV) vaccine remains elusive. We tested the recombinant parainfluenza virus 5 (PIV5) vectors expressing RSV glycoproteins for their immunogenicity and protective efficacy in cotton rats and African green monkeys, which are among the best available animal models to study RSV infection. In both species, a single dose of intranasal immunization with PIV5-vectored vaccines was able to produce systemic and local immunity and to protect animals from RSV challenge. The vaccines could also boost RSV neutralization antibody titers in African green monkeys that had been infected previously. Our data suggest that PIV5-vectored vaccines could potentially protect both the pediatric and elderly populations and support continued development of the vector platform. Copyright © 2017 American Society for Microbiology.

Vero/BC-F: an efficient packaging cell line stably expressing F protein to generate single round-infectious human parainfluenza virus type 2 vector.

PubMed

Ohtsuka, J; Fukumura, M; Tsurudome, M; Hara, K; Nishio, M; Kawano, M; Nosaka, T

2014-08-01

A stable packaging cell line (Vero/BC-F) constitutively expressing fusion (F) protein of the human parainfluenza virus type 2 (hPIV2) was established for production of the F-defective and single round-infectious hPIV2 vector in a strategy for recombinant vaccine development. The F gene expression has not evoked cytostatic or cytotoxic effects on the Vero/BC-F cells and the F protein was physiologically active to induce syncytial formation with giant polykaryocytes when transfected with a plasmid expressing hPIV2 hemagglutinin-neuraminidase (HN). Transduction of the F-defective replicon RNA into the Vero/BC-F cells led to the release of the infectious particles that packaged the replicon RNA (named as hPIV2ΔF) without detectable mutations, limiting the infectivity to a single round. The maximal titer of the hPIV2ΔF was 6.0 × 10(8) median tissue culture infections dose per ml. The influenza A virus M2 gene was inserted into hPIV2ΔF, and the M2 protein was found to be highly expressed in a human lung cancer cell line after transduction. Furthermore, in vivo airway infection experiments revealed that the hPIV2ΔF was capable of delivering transgenes to hamster tracheal cells. Thus, non-transmissible or single round-infectious hPIV2 vector will be potentially applicable to human gene therapy or recombinant vaccine development.

Modeling the missile-launch tube problem in DYSCO

NASA Technical Reports Server (NTRS)

Berman, Alex; Gustavson, Bruce A.

1989-01-01

DYSCO is a versatile, general purpose dynamic analysis program which assembles equations and solves dynamics problems. The executive manages a library of technology modules which contain routines that compute the matrix coefficients of the second order ordinary differential equations of the components. The executive performs the coupling of the equations of the components and manages the solution of the coupled equations. Any new component representation may be added to the library if, given the state vector, a FORTRAN program can be written to compute M, C, K, and F. The problem described demonstrates the generality of this statement.

Ovicidal activity of Metarhizium brunneum (Mb F52) on dengue fever vector, Aedes aegypti

USDA-ARS?s Scientific Manuscript database

The ovicidal activity of Metarhizium brunneum F52 (Mb F52) grown from granules was evaluated against Aedes aegypti eggs over time. Survival of larvae from treated eggs was significantly less when compared with untreated eggs at 7, 10 and 14 days post treatment. Only 27 % of treated eggs produced vi...

Effective gravitational coupling in modified teleparallel theories

NASA Astrophysics Data System (ADS)

Abedi, Habib; Capozziello, Salvatore; D'Agostino, Rocco; Luongo, Orlando

2018-04-01

In the present study, we consider an extended form of teleparallel Lagrangian f (T ,ϕ ,X ) , as function of a scalar field ϕ , its kinetic term X and the torsion scalar T . We use linear perturbations to obtain the equation of matter density perturbations on sub-Hubble scales. The gravitational coupling is modified in scalar modes with respect to the one of general relativity, albeit vector modes decay and do not show any significant effects. We thus extend these results by involving multiple scalar field models. Further, we study conformal transformations in teleparallel gravity and we obtain the coupling as the scalar field is nonminimally coupled to both torsion and boundary terms. Finally, we propose the specific model f (T ,ϕ ,X )=T +∂μϕ ∂μϕ +ξ T ϕ2 . To check its goodness, we employ the observational Hubble data, constraining the coupling constant, ξ , through a Monte Carlo technique based on the Metropolis-Hastings algorithm. Hence, fixing ξ to its best-fit value got from our numerical analysis, we calculate the growth rate of matter perturbations and we compare our outcomes with the latest measurements and the predictions of the Λ CDM model.

Multiaxis control power from thrust vectoring for a supersonic fighter aircraft model at Mach 0.20 to 2.47

NASA Technical Reports Server (NTRS)

Capone, Francis J.; Bare, E. Ann

1987-01-01

The aeropropulsive characteristics of an advanced twin-engine fighter aircraft designed for supersonic cruise have been studied in the Langley 16-Foot Tansonic Tunnel and the Lewis 10- by 10-Foot Supersonic Tunnel. The objective was to determine multiaxis control-power characteristics from thrust vectoring. A two-dimensional convergent-divergent nozzle was designed to provide yaw vector angles of 0, -10, and -20 deg combined with geometric pitch vector angles of 0 and 15 deg. Yaw thrust vectoring was provided by yaw flaps located in the nozzle sidewalls. Roll control was obtained from differential pitch vectoring. This investigation was conducted at Mach numbers from 0.20 to 2.47. Angle of attack was varied from 0 to about 19 deg, and nozzle pressure ratio was varied from about 1 (jet off) to 28, depending on Mach number. Increments in force or moment coefficient that result from pitch or yaw thrust vectoring remain essentially constant over the entire angle-of-attack range of all Mach numbers tested. There was no effect of pitch vectoring on the lateral aerodynamic forces and moments and only very small effects of yaw vectoring on the longitudinal aerodynamic forces and moments. This result indicates little cross-coupling of control forces and moments for combined pitch-yaw vectoring.

Maize Chlorotic Mottle Virus Induces Changes in Host Plant Volatiles that Attract Vector Thrips Species.

PubMed

Mwando, Nelson L; Tamiru, Amanuel; Nyasani, Johnson O; Obonyo, Meshack A O; Caulfield, John C; Bruce, Toby J A; Subramanian, Sevgan

2018-06-02

Maize lethal necrosis is one of the most devastating diseases of maize causing yield losses reaching up to 90% in sub-Saharan Africa. The disease is caused by a combination of maize chlorotic mottle virus (MCMV) and any one of cereal viruses in the Potyviridae group such as sugarcane mosaic virus. MCMV has been reported to be transmitted mainly by maize thrips (Frankliniella williamsi) and onion thrips (Thrips tabaci). To better understand the role of thrips vectors in the epidemiology of the disease, we investigated behavioral responses of F. williamsi and T. tabaci, to volatiles collected from maize seedlings infected with MCMV in a four-arm olfactometer bioassay. Volatile profiles from MCMV-infected and healthy maize plants were compared by gas chromatography (GC) and GC coupled mass spectrometry analyses. In the bioassays, both sexes of F. williamsi and male T. tabaci were significantly attracted to volatiles from maize plants infected with MCMV compared to healthy plants and solvent controls. Moreover, volatile analysis revealed strong induction of (E)-4,8-dimethyl-1,3,7-nonatriene, methyl salicylate and (E,E)-4,8,12-trimethyltrideca-1,3,7,11-tetraene in MCMV-infected maize seedlings. Our findings demonstrate MCMV induces changes in volatile profiles of host plants to elicit attraction of thrips vectors. The increased vector contact rates with MCMV-infected host plants could enhance virus transmission if thrips feed on the infected plants and acquire the pathogen prior to dispersal. Uncovering the mechanisms mediating interactions between vectors, host plants and pathogens provides useful insights for understanding the vector ecology and disease epidemiology, which in turn may contribute in designing integrated vector management strategies.

Electron-phonon mediated heat flow in disordered graphene

NASA Astrophysics Data System (ADS)

Chen, Wei; Clerk, Aashish A.

2012-09-01

We calculate the heat flux and electron-phonon thermal conductance in a disordered graphene sheet, going beyond a Fermi’s golden rule approach to fully account for the modification of the electron-phonon interaction by disorder. Using the Keldysh technique combined with standard impurity averaging methods in the regime kFl≫1 (where kF is the Fermi wave vector and l is the mean free path), we consider both scalar potential (i.e., deformation potential) and vector-potential couplings between electrons and phonons. We also consider the effects of electronic screening at the Thomas-Fermi level. We find that the temperature dependence of the heat flux and thermal conductance is sensitive to the presence of disorder and screening, and reflects the underlying chiral nature of electrons in graphene and the corresponding modification of their diffusive behavior. In the case of weak screening, disorder enhances the low-temperature heat flux over the clean system (changing the associated power law from T4 to T3), and the deformation potential dominates. For strong screening, both the deformation potential and vector-potential couplings make comparable contributions, and the low-temperature heat flux obeys a T5 power law.

750 GeV diphotons: implications for supersymmetric unification

DOE Office of Scientific and Technical Information (OSTI.GOV)

Hall, Lawrence J.; Harigaya, Keisuke; Nomura, Yasunori

2016-03-03

A recent signal of 750 GeV diphotons at the LHC can be explained within the framework of supersymmetric unification by the introduction of vector quarks and leptons with Yukawa couplings to a singlet S that describes the 750 GeV resonance. We study the most general set of theories that allow successful gauge coupling unification, and find that these Yukawa couplings are severely constrained by renormalization group behavior: they are independent of ultraviolet physics and flow to values at the TeV scale that we calculate precisely. As a consequence the vector quarks and leptons must be light; typically in the regionmore » of 375 GeV to 700 GeV, and in certain cases up to 1 TeV. The 750 GeV resonance may have a width less than the experimental resolution; alternatively, with the mass splitting between scalar and pseudoscalar components of S arising from one-loop diagrams involving vector fermions, we compute an apparent width of 10s of GeV.« less

Physical results from 2+1 flavor domain wall QCD and SU(2) chiral perturbation theory

DOE Office of Scientific and Technical Information (OSTI.GOV)

Allton, C.; Antonio, D. J.; Boyle, P. A.

2008-12-01

We have simulated QCD using 2+1 flavors of domain wall quarks and the Iwasaki gauge action on a (2.74 fm){sup 3} volume with an inverse lattice scale of a{sup -1}=1.729(28) GeV. The up and down (light) quarks are degenerate in our calculations and we have used four values for the ratio of light quark masses to the strange (heavy) quark mass in our simulations: 0.217, 0.350, 0.617, and 0.884. We have measured pseudoscalar meson masses and decay constants, the kaon bag parameter B{sub K}, and vector meson couplings. We have used SU(2) chiral perturbation theory, which assumes only the upmore » and down quark masses are small, and SU(3) chiral perturbation theory to extrapolate to the physical values for the light quark masses. While next-to-leading order formulas from both approaches fit our data for light quarks, we find the higher-order corrections for SU(3) very large, making such fits unreliable. We also find that SU(3) does not fit our data when the quark masses are near the physical strange quark mass. Thus, we rely on SU(2) chiral perturbation theory for accurate results. We use the masses of the {omega} baryon, and the {pi} and K mesons to set the lattice scale and determine the quark masses. We then find f{sub {pi}}=124.1(3.6){sub stat}(6.9){sub syst} MeV, f{sub K}=149.6(3.6){sub stat}(6.3){sub syst} MeV, and f{sub K}/f{sub {pi}}=1.205(0.018){sub stat}(0.062){sub syst}. Using nonperturbative renormalization to relate lattice regularized quark masses to regularization independent momentum scheme masses, and perturbation theory to relate these to MS, we find m{sub ud}{sup MS}(2 GeV)=3.72(0.16){sub stat}(0.33){sub ren}(0.18){sub syst} MeV, m{sub s}{sup MS}(2 GeV)=107.3(4.4){sub stat}(9.7){sub ren}(4.9){sub syst} MeV, and m-tilde{sub ud} ratio m-tilde{sub s}=1 ratio 28.8(0.4){sub stat}(1.6){sub syst}. For the kaon bag parameter, we find B{sub K}{sup MS}(2 GeV)=0.524(0.010){sub stat}(0.013){sub ren}(0.025){sub syst}. Finally, for the ratios of the couplings of the vector mesons to the vector and tensor currents (f{sub V} and f{sub V}{sup T}, respectively) in the MS scheme at 2 GeV we obtain f{sub {rho}}{sup T}/f{sub {rho}}=0.687(27); f{sub K*}{sup T}/f{sub K*}=0.712(12), and f{sub {phi}}{sup T}/f{sub {phi}}=0.750(8)« less

The different varieties of the Suyama-Yamaguchi consistency relation and its violation as a signal of statistical inhomogeneity

NASA Astrophysics Data System (ADS)

Rodríguez, Yeinzon; Beltrán Almeida, Juan P.; Valenzuela-Toledo, César A.

2013-04-01

We present the different consistency relations that can be seen as variations of the well known Suyama-Yamaguchi (SY) consistency relation τNL>=((6/5)fNL)2, the latter involving the levels of non-gaussianity fNL and τNL in the primordial curvature perturbation ζ. It has been (implicitly) claimed that the following variation: τNL(k1,k3)>=((6/5))2fNL(k1)fNL(k3), which we call ``the fourth variety'', in the collapsed (for τNL) and squeezed (for fNL) limits is always satisfied independently of any physics; however, the proof depends sensitively on the assumption of scale-invariance (expressing this way the fourth variety of the SY consistency relation as τNL>=((6/5)fNL)2) which only applies for cosmological models involving Lorentz-invariant scalar fields (at least at tree level), leaving room for a strong violation of this variety of the consistency relation when non-trivial degrees of freedom, for instance vector fields, are in charge of the generation of the primordial curvature perturbation. With this in mind as a motivation, we explicitly state, in the first part of this work, under which conditions the SY consistency relation has been claimed to hold in its different varieties (implicitly) presented in the literature since its inception back in 2008; as a result, we show for the first time that the variety τNL(k1,k1)>=((6/5)fNL(k1))2, which we call ``the fifth variety'', is always satisfied even when there is strong scale-dependence and high levels of statistical anisotropy as long as statistical homogeneity holds: thus, an observed violation of this specific variety would prevent the comparison between theory and observation, shaking this way the foundations of cosmology as a science. In the second part, we concern about the existence of non-trivial degrees of freedom, concretely vector fields for which the levels of non-gaussianity have been calculated for very few models; among them, and by making use of the δN formalism at tree level, we study a class of models that includes the vector curvaton scenario, vector inflation, and the hybrid inflation with coupled vector and scalar ``waterfall field'' where ζ is generated at the end of inflation, finding that the fourth variety of the SY consistency relation is indeed strongly violated for some specific wavevector configurations while the fifth variety continues to be well satisfied. Finally, as a byproduct of our investigation, we draw attention to a quite recently demonstrated variety of the SY consistency relation: τisoNL>=((6/5)fisoNL)2, in scenarios where scalar and vector fields contribute to the generation of the primordial curvature perturbation; this variety of the SY consistency relation is satisfied although the isotropic pieces of the non-gaussianity parameters receive contributions from the vector fields. We discuss further implications for observational cosmology.

Dark forces coupled to nonconserved currents

NASA Astrophysics Data System (ADS)

Dror, Jeff A.; Lasenby, Robert; Pospelov, Maxim

2017-10-01

New light vectors with dimension-4 couplings to Standard Model states have (energy/vectormass)2-enhanced production rates unless the current they couple to is conserved. These processes allow us to derive new constraints on the couplings of such vectors, that are significantly stronger than the previous literature for a wide variety of models. Examples include vectors with axial couplings to quarks and vectors coupled to currents (such as baryon number) that are only broken by the chiral anomaly. Our new limits arise from a range of processes, including rare Z decays and flavor-changing meson decays, and rule out a number of phenomenologically motivated proposals.

Nonleptonic decays of B →(f1(1285 ),f1(1420 ))V in the perturbative QCD approach

NASA Astrophysics Data System (ADS)

Liu, Xin; Xiao, Zhen-Jun; Zou, Zhi-Tian

2016-12-01

We investigate the branching ratios, the polarization fractions, the direct C P -violating asymmetries, and the relative phases in 20 nonleptonic decay modes of B →f1V within the framework of the perturbative QCD approach at leading order with f1 including two 3P1-axial-vector states f1(1285 ) and f1(1420 ) . Here, B denotes B+, B0, and Bs0 mesons and V stands for the lightest vector mesons ρ , K*, ω , and ϕ , respectively. The Bs0→f1V decays are studied theoretically for the first time in the literature. Together with the angle ϕf1≈(24-2.7+3.2)∘ extracted from the measurement through Bd /s→J /ψ f1(1285 ) modes for the f1(1285 )-f1(1420 ) mixing system, it is of great interest to find phenomenologically some modes such as the tree-dominated B+→f1ρ+ and the penguin-dominated B+,0→f1K*+,0 , Bs0→f1ϕ with large branching ratios around O (10-6) or even O (10-5), which are expected to be measurable at the LHCb and/or the Belle-II experiments in the near future. The good agreement (sharp contrast) of branching ratios and decay pattern for B+→f1ρ+ , B+,0→f1(1285 )K*+,0[B+,0→f1(1420 )K*+,0] decays between QCD factorization and perturbative QCD factorization predictions can help us to distinguish these two rather different factorization approaches via precision measurements, which would also be helpful for us in exploring the annihilation decay mechanism through its important roles for the considered B →f1V decays.

Low scale composite Higgs model and 1.8 ˜2 TeV diboson excess

NASA Astrophysics Data System (ADS)

Bian, Ligong; Liu, Da; Shu, Jing

2018-04-01

We consider a simple solution to explain the recent diboson excess observed by ATLAS and CMS Collaborations in models with custodial symmetry SU(2)L × SU(2)R → SU(2)c. The SU(2)L triplet vector boson ρ with mass range of 1.8 ˜ 2 TeV would be produced through the Drell-Yan process with sizable diboson decay branching to account for the excess. The other SU(2)L × SU(2)R bidoublet axial vector boson a would cancel all deviations of electroweak obervables induced by ρ even if the SM fermions mix with some heavy vector-like (composite) fermions which couple to ρ (“nonuniversally partially composite”), therefore allows arbitrary couplings between each SM fermion and ρ. We present our model in the “General Composite Higgs” framework with SO(5) × U(1)X → SO(4) × U(1)X breaking at scale f and demand the first Weinberg sum rule and positive gauge boson form factors as the theoretical constraints. We find that our model can fit the diboson excess very well if the left-handed SM light quarks, charged leptons and tops have zero, zero/moderately small and moderate/large composite components for reasonable values of gρ and f. The correlation between tree level S parameter and the h → Zγ suggest a large a contribution to h → Zγ and it is indeed a 𝒪(1) effect in our parameter space which provides a strong hint for our scenario if this diboson excess is confirmed by the 13 ˜ 14 TeV LHC Run II.

Tensor form factor for the D → π(K) transitions with Twisted Mass fermions.

NASA Astrophysics Data System (ADS)

Lubicz, Vittorio; Riggio, Lorenzo; Salerno, Giorgio; Simula, Silvano; Tarantino, Cecilia

2018-03-01

We present a preliminary lattice calculation of the D → π and D → K tensor form factors fT (q2) as a function of the squared 4-momentum transfer q2. ETMC recently computed the vector and scalar form factors f+(q2) and f0(q2) describing D → π(K)lv semileptonic decays analyzing the vector current and the scalar density. The study of the weak tensor current, which is directly related to the tensor form factor, completes the set of hadronic matrix element regulating the transition between these two pseudoscalar mesons within and beyond the Standard Model where a non-zero tensor coupling is possible. Our analysis is based on the gauge configurations produced by the European Twisted Mass Collaboration with Nf = 2 + 1 + 1 flavors of dynamical quarks. We simulated at three different values of the lattice spacing and with pion masses as small as 210 MeV and with the valence heavy quark in the mass range from ≃ 0.7 mc to ≃ 1.2mc. The matrix element of the tensor current are determined for a plethora of kinematical conditions in which parent and child mesons are either moving or at rest. As for the vector and scalar form factors, Lorentz symmetry breaking due to hypercubic effects is clearly observed in the data. We will present preliminary results on the removal of such hypercubic lattice effects.

Reynolds number of transition and self-organized criticality of strong turbulence.

PubMed

Yakhot, Victor

2014-10-01

A turbulent flow is characterized by velocity fluctuations excited in an extremely broad interval of wave numbers k>Λf, where Λf is a relatively small set of the wave vectors where energy is pumped into fluid by external forces. Iterative averaging over small-scale velocity fluctuations from the interval Λf

Reynolds number of transition and self-organized criticality of strong turbulence

NASA Astrophysics Data System (ADS)

Yakhot, Victor

2014-10-01

A turbulent flow is characterized by velocity fluctuations excited in an extremely broad interval of wave numbers k >Λf , where Λf is a relatively small set of the wave vectors where energy is pumped into fluid by external forces. Iterative averaging over small-scale velocity fluctuations from the interval Λf

Improved Prefusion Stability, Optimized Codon Usage, and Augmented Virion Packaging Enhance the Immunogenicity of Respiratory Syncytial Virus Fusion Protein in a Vectored-Vaccine Candidate

PubMed Central

Liang, Bo; Ngwuta, Joan O.; Surman, Sonja; Kabatova, Barbora; Liu, Xiang; Lingemann, Matthias; Liu, Xueqiao; Yang, Lijuan; Herbert, Richard; Swerczek, Joanna; Chen, Man; Moin, Syed M.; Kumar, Azad; McLellan, Jason S.; Kwong, Peter D.; Graham, Barney S.; Collins, Peter L.

2017-01-01

ABSTRACT Respiratory syncytial virus (RSV) is the most important viral agent of severe pediatric respiratory tract disease worldwide, but it lacks a licensed vaccine or suitable antiviral drug. A live attenuated chimeric bovine/human parainfluenza virus type 3 (rB/HPIV3) was developed previously as a vector expressing RSV fusion (F) protein to confer bivalent protection against RSV and HPIV3. In a previous clinical trial in virus-naive children, rB/HPIV3 was well tolerated but the immunogenicity of wild-type RSV F was unsatisfactory. We previously modified RSV F with a designed disulfide bond (DS) to increase stability in the prefusion (pre-F) conformation and to be efficiently packaged in the vector virion. Here, we further stabilized pre-F by adding both disulfide and cavity-filling mutations (DS-Cav1), and we also modified RSV F codon usage to have a lower CpG content and a higher level of expression. This RSV F open reading frame was evaluated in rB/HPIV3 in three forms: (i) pre-F without vector-packaging signal, (ii) pre-F with vector-packaging signal, and (iii) secreted pre-F ectodomain trimer. Despite being efficiently expressed, the secreted pre-F was poorly immunogenic. DS-Cav1 stabilized pre-F, with or without packaging, induced higher titers of pre-F specific antibodies in hamsters, and improved the quality of RSV-neutralizing serum antibodies. Codon-optimized RSV F containing fewer CpG dinucleotides had higher F expression, replicated more efficiently in vivo, and was more immunogenic. The combination of DS-Cav1 pre-F stabilization, optimized codon usage, reduced CpG content, and vector packaging significantly improved vector immunogenicity and protective efficacy against RSV. This provides an improved vectored RSV vaccine candidate suitable for pediatric clinical evaluation. IMPORTANCE RSV and HPIV3 are the first and second leading viral causes of severe pediatric respiratory disease worldwide. Licensed vaccines or suitable antiviral drugs are not available. We are developing a chimeric rB/HPIV3 vector expressing RSV F as a bivalent RSV/HPIV3 vaccine and have been evaluating means to increase RSV F immunogenicity. In this study, we evaluated the effects of improved stabilization of F in the pre-F conformation and of codon optimization resulting in reduced CpG content and greater pre-F expression. Reduced CpG content dampened the interferon response to infection, promoting higher replication and increased F expression. We demonstrate that improved pre-F stabilization and strategic manipulation of codon usage, together with efficient pre-F packaging into vector virions, significantly increased F immunogenicity in the bivalent RSV/HPIV3 vaccine. The improved immunogenicity included induction of increased titers of high-quality complement-independent antibodies with greater pre-F site Ø binding and greater protection against RSV challenge. PMID:28539444

Novel Listeria Vectors Secreting Gut Flora Altering Agents to Prevent Colon Cancer and Treat Colitis

DTIC Science & Technology

2016-09-01

L1 KO cell line using CRISPR to optimize library screening for anti-B7-H1 scFv. We collected useful data on immune and signaling events in colon...down B7-H1 in the B16F10 line for screening, but this was also inefficient. We then used CRISPR /Cas9 to effect a total KO of B7-H1 in the B16F10 cell

Constraints on exotic dipole-dipole couplings between electrons at the micron scale

NASA Astrophysics Data System (ADS)

Kotler, Shlomi; Ozeri, Roee; Jackson Kimball, Derek

2015-05-01

Until recently, the magnetic dipole-dipole coupling between electrons had not been directly observed experimentally. This is because at the atomic scale dipole-dipole coupling is dominated by the exchange interaction and at larger distances the dipole-dipole coupling is overwhelmed by ambient magnetic field noise. In spite of these challenges, the magnetic dipole-dipole interaction between two electron spins separated by 2.4 microns was recently measured using the valence electrons of trapped Strontium ions [S. Kotler, N. Akerman, N. Navon, Y. Glickman, and R. Ozeri, Nature 510, 376 (2014)]. We have used this measurement to directly constrain exotic dipole-dipole interactions between electrons at the micron scale. For light bosons (mass 0.1 eV), we find that coupling constants describing pseudoscalar and axial-vector mediated interactions must be | gPegPe/4 πℏc | <= 1 . 5 × 10-3 and | gAegAe/4 πℏc | <= 1 . 2 × 10-17 , respectively, at the 90% confidence level. These bounds significantly improve on previous constraints in this mass range: for example, the constraints on axial-vector interactions are six orders of magnitude stronger than electron-positron constraints based on positronium spectroscopy. Supported by the National Science Foundation, I-Core: the Israeli excellence center, and the European Research Council.

Non-universal Z‧ from fluxed GUTs

NASA Astrophysics Data System (ADS)

Crispim Romao, Miguel; King, Stephen F.; Leontaris, George K.

2018-07-01

We make a first systematic study of non-universal TeV scale neutral gauge bosons Z‧ arising naturally from a class of F-theory inspired models broken via SU (5) by flux. The phenomenological models we consider may originate from semi-local F-theory GUTs arising from a single E8 point of local enhancement, assuming the minimal Z2 monodromy in order to allow for a renormalisable top quark Yukawa coupling. We classify such non-universal anomaly-free U(1) ‧ models requiring a minimal low energy spectrum and also allowing for a vector-like family. We discuss to what extent such models can account for the anomalous B-decay ratios RK and RK*.

Acoustic Vector-Sensor Array Processing

DTIC Science & Technology

2010-06-01

NUMBER 6. AUTHOR(S) 5d. PROJECT NUMBER 5e. TASK NUMBER 5f. WORK UNIT NUMBER 7. PERFORMING ORGANIZATION NAME(S) AND ADDRESS( ES ) Massachusetts Institute...ADDRESS( ES ) 10. SPONSOR/MONITOR’S ACRONYM(S) 11. SPONSOR/MONITOR’S REPORT NUMBER(S) 12. DISTRIBUTION/AVAILABILITY STATEMENT Approved for public...section shows, vector-sensor arrays are more versatile than arrays of only pressure-sensors. Exploiting this versatility raises a number of ques

Dryden/Edwards 1994 Thrust-Vectoring Aircraft Fleet - F-18 HARV, X-31, F-16 MATV

NASA Technical Reports Server (NTRS)

1994-01-01

The three thrust-vectoring aircraft at Edwards, California, each capable of flying at extreme angles of attack, cruise over the California desert in formation during flight in March 1994. They are, from left, NASA's F-18 High Alpha Research Vehicle (HARV), flown by the NASA Dryden Flight Research Center; the X-31, flown by the X-31 International Test Organization (ITO) at Dryden; and the Air Force F-16 Multi-Axis Thrust Vectoring (MATV) aircraft. All three aircraft were flown in different programs and were developed independently. The NASA F-18 HARV was a testbed to produce aerodynamic data at high angles of attack to validate computer codes and wind tunnel research. The X-31 was used to study thrust vectoring to enhance close-in air combat maneuvering, while the F-16 MATV was a demonstration of how thrust vectoring could be applied to operational aircraft.

Motion of the guest ion as precursor to the first-order phase transition in the cage system GdB6

NASA Astrophysics Data System (ADS)

Iwasa, Kazuaki; Igarashi, Ryosuke; Saito, Kotaro; Laulhé, Claire; Orihara, Toshihiko; Kunii, Satoru; Kuwahara, Keitaro; Nakao, Hironori; Murakami, Youichi; Iga, Fumitoshi; Sera, Masafumi; Tsutsui, Satoshi; Uchiyama, Hiroshi; Baron, Alfred Q. R.

2011-12-01

The motion of guest Gd ions in oversized boron cages in GdB6 was investigated from phonon spectra measurements obtained by inelastic x-ray scattering. The measured phonon modes soften by about 10% from 300 K down to TN=16 K, in particular, the longitudinal phonon for the propagation vector q1=(1/2,0,0) that characterizes the distorted structure below TN. Besides, the dispersion relation curves show kinklike anomalies at qk=(0.38,0.38,0). The observed results imply that the motion of the guest Gd ion interplays with the f electrons magnetoelastically and with carriers via Fermi surface nesting. The anomalous properties previously reported for this material far above TN originate from the strong electron-phonon coupling, which causes the motion of guest ions as precursors to the first-order phase transition.

Isospin breaking effects in the anomalous processes with vector mesons

NASA Astrophysics Data System (ADS)

Hashimoto, Michio

1996-02-01

We introduce isospin/ SU(3) breaking terms in the anomalous WP coupling in the hidden local symmetry scheme without affecting the low-energy theorem. It is shown that the predictions from these terms coincide successfully with all the experimental data of anomalous decays. It is also predicted that the decay widths of ϱ0 → π0γ and f → η‧γ are 114 ± 7 keV and 0.55 ± 0.055 keV, respectively.

Search for bosonic super-WIMP interactions with the XENON100 experiment

NASA Astrophysics Data System (ADS)

Aprile, E.; Aalbers, J.; Agostini, F.; Alfonsi, M.; Althueser, L.; Amaro, F. D.; Anthony, M.; Arneodo, F.; Barrow, P.; Baudis, L.; Bauermeister, B.; Benabderrahmane, M. L.; Berger, T.; Breur, P. A.; Brown, A.; Brown, A.; Brown, E.; Bruenner, S.; Bruno, G.; Budnik, R.; Bütikofer, L.; Calvén, J.; Capelli, C.; Cardoso, J. M. R.; Cichon, D.; Coderre, D.; Colijn, A. P.; Conrad, J.; Cussonneau, J. P.; Decowski, M. P.; de Perio, P.; di Gangi, P.; di Giovanni, A.; Diglio, S.; Eurin, G.; Fei, J.; Ferella, A. D.; Fieguth, A.; Fulgione, W.; Gallo Rosso, A.; Galloway, M.; Gao, F.; Garbini, M.; Geis, C.; Goetzke, L. W.; Greene, Z.; Grignon, C.; Hasterok, C.; Hogenbirk, E.; Howlett, J.; Itay, R.; Kaminsky, B.; Kazama, S.; Kessler, G.; Kish, A.; Landsman, H.; Lang, R. F.; Lellouch, D.; Levinson, L.; Lin, Q.; Lindemann, S.; Lindner, M.; Lombardi, F.; Lopes, J. A. M.; Manfredini, A.; Maris, I.; Marrodán Undagoitia, T.; Masbou, J.; Massoli, F. V.; Masson, D.; Mayani, D.; Messina, M.; Micheneau, K.; Molinario, A.; Morâ, K.; Murra, M.; Naganoma, J.; Ni, K.; Oberlack, U.; Pakarha, P.; Pelssers, B.; Persiani, R.; Piastra, F.; Pienaar, J.; Pizzella, V.; Piro, M.-C.; Plante, G.; Priel, N.; Ramírez García, D.; Rauch, L.; Reichard, S.; Reuter, C.; Rizzo, A.; Rupp, N.; Dos Santos, J. M. F.; Sartorelli, G.; Scheibelhut, M.; Schindler, S.; Schreiner, J.; Schumann, M.; Scotto Lavina, L.; Selvi, M.; Shagin, P.; Silva, M.; Simgen, H.; Sivers, M. V.; Stein, A.; Thers, D.; Tiseni, A.; Trinchero, G.; Tunnell, C.; Vargas, M.; Wang, H.; Wang, Z.; Wei, Y.; Weinheimer, C.; Wittweg, C.; Wulf, J.; Ye, J.; Zhang, Y.; Zhu, T.; Xenon Collaboration

2017-12-01

We present results of searches for vector and pseudoscalar bosonic super-weakly interacting massive particles (WIMPs), which are dark matter candidates with masses at the keV-scale, with the XENON100 experiment. XENON100 is a dual-phase xenon time projection chamber operated at the Laboratori Nazionali del Gran Sasso. A profile likelihood analysis of data with an exposure of 224.6 live days ×34 kg showed no evidence for a signal above the expected background. We thus obtain new and stringent upper limits in the (8 - 125 ) keV /c2 mass range, excluding couplings to electrons with coupling constants of ga e>3 ×10-13 for pseudo-scalar and α'/α >2 ×10-28 for vector super-WIMPs, respectively. These limits are derived under the assumption that super-WIMPs constitute all of the dark matter in our galaxy.

An electron fixed target experiment to search for a new vector boson A' decaying to e +e -

DOE PAGES

Rouven Essig; Schuster, Philip; Toro, Natalia; ...

2011-02-02

We describe an experiment to search for a new vector boson A' with weak coupling alpha' > 6 x 10 –8 α to electrons (α' = e 2/4π) in the mass range 65 MeV < m A' < 550 MeV. New vector bosons with such small couplings arise naturally from a small kinetic mixing of the "dark photon" A' with the photon -- one of the very few ways in which new forces can couple to the Standard Model -- and have received considerable attention as an explanation of various dark matter related anomalies. A' bosons are produced by radiationmore » off an electron beam, and could appear as narrow resonances with small production cross-section in the trident e +e - spectrum. We summarize the experimental approach described in a proposal submitted to Jefferson Laboratory's PAC35, PR-10-009. This experiment, the A' Experiment (APEX), uses the electron beam of the Continuous Electron Beam Accelerator Facility at Jefferson Laboratory (CEBAF) at energies of ~1-4 GeV incident on 0.5-10% radiation length Tungsten wire mesh targets, and measures the resulting e+e- pairs to search for the A' using the High Resolution Spectrometer and the septum magnet in Hall A. With a ~1 month run, APEX will achieve very good sensitivity because the statistics of e+e- pairs will be ~10,000 times larger in the explored mass range than any previous search for the A' boson. These statistics and the excellent mass resolution of the spectrometers allow sensitivity to α'/α one to three orders of magnitude below current limits, in a region of parameter space of great theoretical and phenomenological interest. Similar experiments could also be performed at other facilities, such as the Mainz Microtron.« less

Dynamics of entropy and nonclassical properties of the state of a Λ-type three-level atom interacting with a single-mode cavity field with intensity-dependent coupling in a Kerr medium

NASA Astrophysics Data System (ADS)

Faghihi, M. J.; Tavassoly, M. K.

2012-02-01

In this paper, we study the interaction between a three-level atom and a quantized single-mode field with ‘intensity-dependent coupling’ in a ‘Kerr medium’. The three-level atom is considered to be in a Λ-type configuration. Under particular initial conditions, which may be prepared for the atom and the field, the dynamical state vector of the entire system will be explicitly obtained, for the arbitrary nonlinearity function f(n) associated with any physical system. Then, after evaluating the variation of the field entropy against time, we will investigate the quantum statistics as well as some of the nonclassical properties of the introduced state. During our calculations we investigate the effects of intensity-dependent coupling, Kerr medium and detuning parameters on the depth and domain of the nonclassicality features of the atom-field state vector. Finally, we compare our obtained results with those of V-type three-level atoms.

Anisotropy of critical correlations in moderately delocalized cerium and actinide systems

NASA Astrophysics Data System (ADS)

Kioussis, Nicholas; Cooper, Bernard R.

1986-09-01

The equilibrium and excitation magnetic behavior of a class of cerium and light actinide compounds have been explained previously, in a theory first developed by Siemann and Cooper, in terms of a band-f-electron anisotropic hybridization-mediated two-ion interaction of the Coqblin-Schrieffer type. Using the same theory, we present here a calculation, within the random-phase approximation, of the longitudinal component of the static wave-vector-dependent susceptibility in the paramagnetic phase. The calculations have been performed in the presence of a cubic crystal field (CF) and yield results for the ratio of inverse critical correlation lengths, κ/κ⊥, parallel and perpendicular to the moment direction, that compare well with those of diffuse critical neutron scattering experiments. In Ce3+ (f1) compounds, we find that as the CF interaction (Γ7 ground state) predominates over the two-ion interaction, the relative strength of the coupling within the ferromagnetic \\{001\\} planes (with moments perpendicular to the planes) and that between the \\{001\\} planes is gradually reversed, resulting in a ratio κ/κ⊥ smaller than unity, as is experimentally observed. We also present results for the effect of differing intraionic (L-S, intermediate, and j-j) coupling on κ/κ⊥ for the case of Pu3+(f5) and U3+(f3) compounds.

Synthesis and characterization of novel amphiphilic copolymer stearic acid-coupled F127 nanoparticles for nano-technology based drug delivery system.

PubMed

Gao, Qihe; Liang, Qing; Yu, Fei; Xu, Jian; Zhao, Qihua; Sun, Baiwang

2011-12-01

Pluronic, F127, amphiphilic block copolymers, are used for several applications, including drug delivery systems. The critical micelle concentration (CMC) of F127 is about 0.26-0.8 wt% so that the utility of F127 in nano-technology based drug delivery system is limited since the nano-sized micelles could dissociate upon dilution. Herein, stearic acid (SA) was simply coupled to F127 between the carboxyl group of SA and the hydroxyl group of F127, which formed a novel copolymer named as SA-coupled F127, with significantly lower CMC. Above the CMC 6.9 × 10(-5)wt%, SA-coupled F127 self-assembled stable nanoparticles with Zeta potential -36 mV. Doxorubicin (DOX)-loaded nanoparticles were made, with drug loading (DL) 5.7 wt% and Zeta potential -36 to -39 mV, and the nanoparticles exhibited distinct shape with the size distribution from 20 to 50 nm. DOX-loaded nanoparticles were relatively stable and exhibited DOX dependant cytotoxicity toward MCF-7 cells in vitro. These results suggest that SA-coupled F127 potentially could be applied as a nano-technology based drug delivery method. Copyright © 2011 Elsevier B.V. All rights reserved.

Magnetosphere-Ionosphere-Thermosphere Response to Quasi-periodic Oscillations in Solar Wind Driving Conditions

NASA Astrophysics Data System (ADS)

Liu, J.; Wang, W.; Zhang, B.; Huang, C.

2017-12-01

Periodical oscillations with periods of several tens of minutes to several hours are commonly seen in the Alfven wave embedded in the solar wind. It is yet to be known how the solar wind oscillation frequency modulates the solar wind-magnetosphere-ionosphere coupled system. Utilizing the Coupled Magnetosphere-Ionosphere-Thermosphere Model (CMIT), we analyzed the magnetosphere-ionosphere-thermosphere system response to IMF Bz oscillation with periods of 10, 30, and 60 minutes from the perspective of energy budget and electrodynamic coupling processes. Our results indicate that solar wind energy coupling efficiency depends on IMF Bz oscillation frequency; energy coupling efficiency, represented by the ratio between globally integrated Joule heating and Epsilon function, is higher for lower frequency IMF Bz oscillation. Ionospheric Joule heating dissipation not only depends on the direct solar wind driven process but also is affected by the intrinsic nature of magnetosphere (i.e. loading-unloading process). In addition, ionosphere acts as a low-pass filter and tends to filter out very high-frequency solar wind oscillation (i.e. shorter than 10 minutes). Ionosphere vertical ion drift is most sensitive to IMF Bz oscillation compared to hmF2, and NmF2, while NmF2 is less sensitive. This can account for not synchronized NmF2 and hmF2 response to penetration electric fields in association with fast solar wind changes. This research highlights the critical role of IMF Bz oscillation frequency in constructing energy coupling function and understanding electrodynamic processes in the coupled solar wind-magnetosphere-ionosphere system.

Black hole superradiance signatures of ultralight vectors

NASA Astrophysics Data System (ADS)

Baryakhtar, Masha; Lasenby, Robert; Teo, Mae

2017-08-01

The process of superradiance can extract angular momentum and energy from astrophysical black holes (BHs) to populate gravitationally bound states with an exponentially large number of light bosons. We analytically calculate superradiant growth rates for vectors around rotating BHs in the regime where the vector Compton wavelength is much larger than the BH size. Spin-1 bound states have superradiance times as short as a second around stellar BHs, growing up to a thousand times faster than their spin-0 counterparts. The fast rates allow us to use measurements of rapidly spinning BHs in x-ray binaries to exclude a wide range of masses for weakly coupled spin-1 particles, 5 ×10-14-2 ×10-11 eV ; lighter masses in the range 6 ×10-20-2 ×10-17 eV start to be constrained by supermassive BH spin measurements at a lower level of confidence. We also explore routes to detection of new vector particles possible with the advent of gravitational wave (GW) astronomy. The LIGO-Virgo Collaboration could discover hints of a new light vector particle in statistical analyses of masses and spins of merging BHs. Vector annihilations source continuous monochromatic gravitational radiation which could be observed by current GW observatories. At design sensitivity, Advanced LIGO may measure up to thousands of annihilation signals from within the Milky Way, while hundreds of BHs born in binary mergers across the observable Universe may superradiate vector bound states and become new beacons of monochromatic gravitational waves.

Attenuated Human Parainfluenza Virus Type 1 Expressing the Respiratory Syncytial Virus (RSV) Fusion (F) Glycoprotein from an Added Gene: Effects of Prefusion Stabilization and Packaging of RSV F

PubMed Central

Liu, Xiang; Liang, Bo; Ngwuta, Joan; Liu, Xueqiao; Surman, Sonja; Lingemann, Matthias; Kwong, Peter D.; Graham, Barney S.; Collins, Peter L.

2017-01-01

ABSTRACT Human respiratory syncytial virus (RSV) is the most prevalent worldwide cause of severe respiratory tract infection in infants and young children. Human parainfluenza virus type 1 (HPIV1) also causes severe pediatric respiratory illness, especially croup. Both viruses lack vaccines. Here, we describe the preclinical development of a bivalent RSV/HPIV1 vaccine based on a recombinant HPIV1 vector, attenuated by a stabilized mutation, that expresses RSV F protein modified for increased stability in the prefusion (pre-F) conformation by previously described disulfide bond (DS) and hydrophobic cavity-filling (Cav1) mutations. RSV F was expressed from the first or second gene position as the full-length protein or as a chimeric protein with its transmembrane and cytoplasmic tail (TMCT) domains substituted with those of HPIV1 F in an effort to direct packaging in the vector particles. All constructs were recovered by reverse genetics. The TMCT versions of RSV F were packaged in the rHPIV1 particles much more efficiently than their full-length counterparts. In hamsters, the presence of the RSV F gene, and in particular the TMCT versions, was attenuating and resulted in reduced immunogenicity. However, the vector expressing full-length RSV F from the pre-N position was immunogenic for RSV and HPIV1. It conferred complement-independent high-quality RSV-neutralizing antibodies at titers similar to those of wild-type RSV and provided protection against RSV challenge. The vectors exhibited stable RSV F expression in vitro and in vivo. In conclusion, an attenuated rHPIV1 vector expressing a pre-F-stabilized form of RSV F demonstrated promising immunogenicity and should be further developed as an intranasal pediatric vaccine. IMPORTANCE RSV and HPIV1 are major viral causes of acute pediatric respiratory illness for which no vaccines or suitable antiviral drugs are available. The RSV F glycoprotein is the major RSV neutralization antigen. We used a rHPIV1 vector, bearing a stabilized attenuating mutation, to express the RSV F glycoprotein bearing amino acid substitutions that increase its stability in the pre-F form, the most immunogenic form that elicits highly functional virus-neutralizing antibodies. RSV F was expressed from the pre-N or N-P gene position of the rHPIV1 vector as a full-length protein or as a chimeric form with its TMCT domain derived from HPIV1 F. TMCT modification greatly increased packaging of RSV F into the vector particles but also increased vector attenuation in vivo, resulting in reduced immunogenicity. In contrast, full-length RSV F expressed from the pre-N position was immunogenic, eliciting complement-independent RSV-neutralizing antibodies and providing protection against RSV challenge. PMID:28835504

Reconstruction of fetal vector electrocardiogram from maternal abdominal signals under fetus body rotations.

PubMed

Nabeshima, Yuji; Kimura, Yoshitaka; Ito, Takuro; Ohwada, Kazunari; Karashima, Akihiro; Katayama, Norihiro; Nakao, Mitsuyuki

2013-01-01

Fetal electrocardiogram (fECG) and its vector form (fVECG) could provide significant clinical information concerning physiological conditions of a fetus. So far various independent component analysis (ICA)-based methods for extracting fECG from maternal abdominal signals have been proposed. Because full extraction of component waves such as P, Q, R, S, and T, is difficult to be realized under noisy and nonstationary situations, the fVECG is further hard to be reconstructed, where different projections of the fetal heart vector are required. In order to reconstruct fVECG, we proposed a novel method for synthesizing different projections of the heart vector, making good use of the fetus movement. This method consists of ICA, estimation of rotation angles of fetus, and synthesis of projections of the heart vector. Through applications to the synthetic and actual data, our method is shown to precisely estimate rotation angle of the fetus and to successfully reconstruct the fVECG.

Shallow-trap-induced positive absorptive two-beam coupling 'gain' and light-induced transparency in nominally undoped barium titanate

NASA Technical Reports Server (NTRS)

Garrett, M. H.; Tayebati, P.; Chang, J. Y.; Jenssen, H. P.; Warde, C.

1992-01-01

The asymmetry of beam coupling with respect to the orientation of the polar axis in a nominally undoped barium titanate crystal is used to determine the electro-optic and absorptive 'gain' in the usual beam-coupling geometry. For small grating wave vectors, the electrooptic coupling vanishes but the absorptive coupling remains finite and positive. Positive absorptive coupling at small grating wave vectors is correlated with the light-induced transparency of the crystal described herein. The intensity and grating wave vector dependence of the electrooptic and absorptive coupling, and the light-induced transparency are consistent with a model incorporating deep and shallow levels.

Current Methodologies for the Analysis of Contingency Tables: Robustness with Respect to Small Expected Values.

DTIC Science & Technology

1982-06-09

40 @ "o VAi %P t 00493f "f t0 IVI Ř "f %,?I 0N% &p &~9. - 4F.904 S d @ 4P099 4U d 909@ 00F 99@ 5 44%4#f m 999F.490F~pPd.5 WAPd 040Pdp.4Pd44090095...64 គ 67 22 21 63 គ 51 18 51 គ ’-, IS N -- -. - . . . . . . . . . - .. .. - .. - 71 264 MINIMUM N (N) TABLE: 2 x5 .10__ .05 .01 VECTOR K P G K P...the Use and Interpretation of Certain Test Cviteria for the Purpose of Statistical Inference, Part II", Biometrika, 20, 264 -299. Odoroff, C. L. (1970

Low molecular weight polyethylenimine cross-linked by 2-hydroxypropyl-gamma-cyclodextrin coupled to peptide targeting HER2 as a gene delivery vector.

PubMed

Huang, Hongliang; Yu, Hai; Tang, Guping; Wang, Qingqing; Li, Jun

2010-03-01

Gene delivery is one of the critical steps for gene therapy. Non-viral vectors have many advantages but suffered from low gene transfection efficiency. Here, in order to develop new polymeric gene vectors with low cytotoxicity and high gene transfection efficiency, we synthesized a cationic polymer composed of low molecular weight polyethylenimine (PEI) of molecular weight of 600 Da cross-linked by 2-hydroxypropyl-gamma-cyclodextrin (HP gamma-CD) and then coupled to MC-10 oligopeptide containing a sequence of Met-Ala-Arg-Ala-Lys-Glu. The oligopeptide can target to HER2, the human epidermal growth factor receptor 2, which is often over expressed in many breast and ovary cancers. The new gene vector was expected to be able to target delivery of genes to HER2 positive cancer cells for gene therapy. The new gene vector was composed of chemically bonded HP gamma-CD, PEI (600 Da), and MC-10 peptide at a molar ratio of 1:3.3:1.2. The gene vector could condense plasmid DNA at an N/P ratio of 6 or above. The particle size of HP gamma-CD-PEI-P/DNA complexes at N/P ratios 40 was around 170-200 nm, with zeta potential of about 20 mV. The gene vector showed very low cytotoxicity, strong targeting specificity to HER2 receptor, and high efficiency of delivering DNA to target cells in vitro and in vivo with the reporter genes. The delivery of therapeutic IFN-alpha gene mediated by the new gene vector and the therapeutic efficiency were also studied in mice animal model. The animal study results showed that the new gene vector HP gamma-CD-PEI-P significantly enhanced the anti-tumor effect on tumor-bearing nude mice as compared to PEI (25 kDa), HP gamma-CD-PEI, and other controls, indicating that this new polymeric gene vector is a potential candidate for cancer gene therapy. (c) 2009 Elsevier Ltd. All rights reserved.

Naval Hydrodynamics Symposium (12th) on Boundary Layer Stability and Transition Ship Boundary Layers and Propeller Hull Interaction Cavitation Geophysical Fluid Dynamics.

DTIC Science & Technology

1979-01-01

Reshotko (1974 ,[ rL12 --o-Wazzan, Okamura & D =cq wdx + dLc (6)1 Snith 11970) F a f XJftW 10 u o-0 where g is the dynamic pressure, cfk and cft are co dx...cdx = 1.328 tr (13) xtr f L tr 106 xtr cft dx = 0.074 / )tr: 0 10 20 30 40 e R WALL OVERHEAT,.IT.° Cx FIGURE 2. Variation of transition Reynolds...change in the anqe , is varied. wavenumber vector in addition to the dispersion relation. Even though no aml itude calculations are included in this paper

Lateral hopping of CO on Cu(111) induced by femtosecond laser pulses

NASA Astrophysics Data System (ADS)

Ueba, H.; Ootsuka, Y.; Paulsson, M.; Persson, B. N. J.

2010-09-01

We present a theoretical study of the lateral hopping of a single CO molecule on Cu(111) induced by femtosecond laser pulses by Mehlhorn [Phys. Rev. Lett. 104, 076101 (2010)]10.1103/PhysRevLett.104.076101. Our model assumes an intermode coupling between the CO frustrated translation (FT) and frustrated rotation (FR) modes with a weak and strong electronic friction coupling to hot electrons, respectively, and heat transfer between the FT mode and the substrate phonons. In this model the effective electronic friction coupling of the FT mode depends on the absorbed laser fluence F through the temperature of the FR mode. The calculated hopping yield as a function of F nicely reproduces the nonlinear increase observed above F=4.0J/m2 . It is found that the electronic heating via friction coupling nor the phonon coupling alone cannot explain the experimental result. Both heatings are cooperatively responsible for CO hopping on Cu(111). The electronic heat transfer dominates over the phononic one at high F , where the effective electronic friction coupling becomes larger than the phononic coupling.

A lentiviral vector with expression controlled by E2F-1: A potential tool for the study and treatment of proliferative diseases

DOE Office of Scientific and Technical Information (OSTI.GOV)

Strauss, Bryan E.; Patricio, Juliana Rotelli; Program in Biotechnology, University of Sao Paulo

2006-10-06

We have constructed a lentiviral vector with expression limited to cells presenting active E2F-1 protein, a potential advantage for gene therapy of proliferative diseases. For the FE2FLW vector, the promoter region of the human E2F-1 gene was utilized to drive expression of luciferase cDNA, included as a reporter of viral expression. Primary, immortalized, and transformed cells were transduced with the FE2FLW vector and cell cycle alterations were induced with serum starvation/replacement, contact inhibition or drug treatment, revealing cell cycle-dependent changes in reporter activity. Forced E2F-1 expression, but not E2F-2 or E2F-3, increased reporter activity, indicating a major role for thismore » factor in controlling expression from the FE2FLW virus. We show the utility of this vector as a reporter of E2F-1 and proliferation-dependent cellular alterations upon cytotoxic/cytostatic treatment, such as the introduction of tumor suppressor genes. We propose that the FE2FLW vector may be a starting point for the development of gene therapy strategies for proliferative diseases, such as cancer or restinosis.« less

Comment on "Chiral gauge field and axial anomaly in a Weyl semimetal"

NASA Astrophysics Data System (ADS)

Zhang, Kai; Zhang, Erhu; Zhang, Shengli

2017-12-01

In Liu et al. [Phys. Rev. B 87, 235306 (2013), 10.1103/PhysRevB.87.235306], the authors obtain that the cross coupling between vector gauge field and chiral gauge field can lead to the anomaly of vector current. We demonstrate that this anomaly is not a physical effect. On one hand, it can be regulated out by the proper regulation. On the other hand, it leads to unjustifiable results, the breaking of the vector gauge symmetry and the ambiguous boundary current. Moreover, the effects associated with anomaly of vector current are understood by random phase approximation (RPA) in the paper we comment on. We point out that the RPA cannot describe the effects resulting from the quantum anomaly.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Esterlis, I.; Nosarzewski, B.; Huang, E. W.

The superconducting (SC) and charge-density-wave (CDW) susceptibilities of the two-dimensional Holstein model are computed using determinant quantum Monte Carlo, and compared with results computed using the Migdal-Eliashberg (ME) approach. We access temperatures as low as 25 times less than the Fermi energy, E F, which are still above the SC transition. We find that the SC susceptibility at low T agrees quantitatively with the ME theory up to a dimensionless electron-phonon coupling λ 0 ≈ 0.4 but deviates dramatically for larger λ 0. We find that for large λ 0 and small phonon frequency ω 0 << E F CDWmore » ordering is favored and the preferred CDW ordering vector is uncorrelated with any obvious feature of the Fermi surface.« less

A high-accuracy algorithm for solving nonlinear PDEs with high-order spatial derivatives in 1 + 1 dimensions

DOE Office of Scientific and Technical Information (OSTI.GOV)

Yao, Jian Hua; Gooding, R.J.

1994-06-01

We propose an algorithm to solve a system of partial differential equations of the type u[sub t](x,t) = F(x, t, u, u[sub x], u[sub xx], u[sub xxx], u[sub xxxx]) in 1 + 1 dimensions using the method of lines with piecewise ninth-order Hermite polynomials, where u and F and N-dimensional vectors. Nonlinear boundary conditions are easily incorporated with this method. We demonstrate the accuracy of this method through comparisons of numerically determine solutions to the analytical ones. Then, we apply this algorithm to a complicated physical system involving nonlinear and nonlocal strain forces coupled to a thermal field. 4 refs.,more » 5 figs., 1 tab.« less

Lactococcus lactis carrying the pValac eukaryotic expression vector coding for IL-4 reduces chemically-induced intestinal inflammation by increasing the levels of IL-10-producing regulatory cells.

PubMed

Souza, Bianca Mendes; Preisser, Tatiane Melo; Pereira, Vanessa Bastos; Zurita-Turk, Meritxell; de Castro, Camila Prósperi; da Cunha, Vanessa Pecini; de Oliveira, Rafael Pires; Gomes-Santos, Ana Cristina; de Faria, Ana Maria Caetano; Machado, Denise Carmona Cara; Chatel, Jean-Marc; Azevedo, Vasco Ariston de Carvalho; Langella, Philippe; Miyoshi, Anderson

2016-08-30

Inflammatory bowel diseases are characterized by chronic intestinal inflammation that leads to severe destruction of the intestinal mucosa. Therefore, the understanding of their aetiology as well as the development of new medicines is an important step for the treatment of such diseases. Consequently, the development of Lactococcus lactis strains capable of delivering a eukaryotic expression vector encoding the interleukin 4 (IL-4) of Mus musculus would represent a new strategy for the elaboration of a more effective alternative therapy against Crohn's disease. The murine IL-4 ORF was cloned into the eukaryotic expression vector pValac::dts. The resulting plasmid-pValac::dts::IL-4-was transfected into CHO cells so that its functionality could be evaluated in vitro. With fluorescent confocal microscopy, flow cytometry and ELISA, it was observed that pValac::dts::IL-4-transfected cells produced IL-4, while non-transfected cells and cells transfected with the empty vector did not. Then, pValac::dts::IL-4 was inserted into L. lactis MG1363 FnBPA(+) in order to evaluate the therapeutic potential of the recombinant strain against TNBS-induced colitis. Intragastric administration of L. lactis MG1363 FnBPA(+) (pValac::dts::IL-4) was able to decrease the severity of colitis, with animals showing decreased levels of IL-12, IL-6 and MPO activity; and increased levels of IL-4 and IL-10. Finally, LP-isolated cells from mice administered TNBS were immunophenotyped so that the main IL-4 and IL-10 producers were identified. Mice administered the recombinant strain presented significantly higher percentages of F4/80(+)MHCII(+)Ly6C(-)IL-4(+), F4/80(+)MHCII(+)Ly6C(-)IL-10(+), F4/80(+)MHCII(+)Ly6C(-)CD206(+)CD124(+)IL-10(+) and CD4(+)Foxp3(+)IL10(+) cells compared to the other groups. This study shows that L. lactis MG1363 FnBPA(+) (pValac::dts::IL-4) is a good candidate to maintain the anti-inflammatory and proinflammatory balance in the gastrointestinal tract, increasing the levels of IL-10-secreting regulatory cells and, thus, demonstrating the effectiveness of this novel DNA delivery-based strategy.

Optimizing cardiovascular gene therapy: increased vascular gene transfer with modified adenoviral vectors.

PubMed

Kibbe, M R; Murdock, A; Wickham, T; Lizonova, A; Kovesdi, I; Nie, S; Shears, L; Billiar, T R; Tzeng, E

2000-02-01

Adenovirus is widely used as a vector for gene transfer to the vasculature. However, the efficiency of these vectors can be limited by ineffective viral-target cell interactions. Viral attachment, which largely determines adenoviral tropism, is mediated through binding of the adenoviral fiber coat protein to the Coxsackievirus and adenovirus receptor, while internalization follows binding of the adenoviral RGD motif to alpha(v)-integrin receptors. Modifications of the fiber coat protein sequence have been successful for targeting the adenovirus to more prevalent receptors in the vasculature, including heparan sulfate-containing receptors and alpha(v)-integrin receptors. Modified adenoviral vectors targeted to receptors more prevalent in the vasculature result in an increased transfer efficiency of the virus in vitro and in vivo even in the presence of clinically relevant doses of heparin. We tested 2 modified E1- and E3-deleted Ad5 type adenoviral vectors containing the beta-galactosidase gene. AdZ.F(pK7) contains multiple positively charged lysines in the fiber coat protein that target the adenovirus to heparan sulfate receptors, while AdZ.F(RGD) contains an RGD integrin-binding sequence in the fiber coat protein that allows binding to alpha(v)-integrin receptors. The gene transfer efficiency of these modified viruses was compared in rat aortic smooth muscle cells in vitro and in an in vivo porcine model of balloon-induced arterial injury. Because of the use of heparin during most vascular surgical procedures and the concern that heparin might interfere with the binding of AdZ.F(pK7) to heparan sulfate receptors, the effect of heparin on the in vitro and in vivo transfer efficiency of these 2 modified adenoviruses was evaluated. In vitro infection of rat aortic smooth muscle cells with AdZ.F(pK7) and AdZ.F(RGD) resulted in significantly higher levels of beta-galactosidase expression compared with the unmodified adenovirus (mean +/- SEM, 1766.3 +/- 89.1 and 44.8 +/- 3.4 vs 10.1 +/- 0.7 mU per milligram of protein; P<.001). Following heparin administration, the gene transfer efficiency achieved with AdZ.F(pK7) diminished slightly in a concentration-dependent manner. However, the transfer efficiency was still greater than with the unmodified virus (mean +/- SEM, 1342.3 +/- 101.8 vs 4.8 +/- 0.4 mU per milligram of protein; P<.001). In vivo, following injury to the pig iliac artery with a 4F Fogarty balloon catheter, we found that AdZ.F(pK7) transduced the artery approximately 35-fold more efficiently than AdZ.F and 3-fold more efficiently than AdZ.F(RGD) following the administration of intravenous heparin, 100 U/kg body weight, and heparinized saline irrigation. Modifications of the adenovirus that lead to receptor targeting resulted in significantly improved gene transfer efficiencies. These improvements in transfer efficiencies observed with the modified vectors decreased slightly in the presence of heparin. However, AdZ.F(pK7) was still superior to AdZ.F(RGD) and AdZ.F despite heparin administration. These data demonstrate that modifications of adenoviral vectors that enhance binding to heparan sulfate receptors significantly improve gene transfer efficiency even in the presence of heparin and suggest an approach to optimize gene transfer into blood vessels.

A model system for testing gene vectors using murine tumor cells on the chorioallantoic membrane of the chick embryo.

PubMed

Dani, Sergio U; Espindola, Rachel

2002-06-30

We developed a model system for testing gene vectors, based on the growth of murine tumors on the chorioallantoic membrane (CAM) of embryonic chickens. The ability of selected murine cells to grow on the CAM was rated according to the following criteria: i) formation of tumor masses; ii) metastasis formation; iii) reproducibility; iv) yield, indicated as the number of embryos surviving to assessment time with visible tumors on the CAM; v) maintainability of the cell, both in the original host and the embryonic chick, or 'shuttle maintainability'; vi) detection by the naked eye, and vii) cost/benefit relation. The murine melanoma cell lineage, B16F10, which efficiently forms distinct, pigmented tumor masses and metastases on the CAM, performed better in this model than the murine B61 cell line. In vitro transduction of B16F10 cells with a recombinant adenovirus carrying a construct of the E. coli LacZ gene followed by inoculation onto the CAM resulted in beta-galactosidase expression in the tumor mass growing on the CAM. This model is potentially applicable to preclinical evaluation of gene vectors, especially for gene therapy of cancer.

RGD capsid modification enhances mucosal protective immunity of a non-human primate adenovirus vector expressing Pseudomonas aeruginosa OprF

PubMed Central

Krause, A; Whu, W Z; Qiu, J; Wafadari, D; Hackett, N R; Sharma, A; Crystal, R G; Worgall, S

2013-01-01

Replication-deficient adenoviral (Ad) vectors of non-human serotypes can serve as Ad vaccine platforms to circumvent pre-existing anti-human Ad immunity. We found previously that, in addition to that feature, a non-human primate-based AdC7 vector expressing outer membrane protein F of P. aeruginosa (AdC7OprF) was more potent in inducing lung mucosal and protective immunity compared to a human Ad5-based vector. In this study we analysed if genetic modification of the AdC7 fibre to display an integrin-binding arginine–glycine–aspartic acid (RGD) sequence can further enhance lung mucosal immunogenicity of AdC7OprF. Intratracheal immunization of mice with either AdC7OprF.RGD or AdC7OprF induced robust serum levels of anti-OprF immunoglobulin (Ig)G up to 12 weeks that were higher compared to immunization with the human vectors Ad5OprF or Ad5OprF.RGD. OprF-specific cellular responses in lung T cells isolated from mice immunized with AdC7OprF.RGD and AdC7OprF were similar for T helper type 1 (Th1) [interferon (IFN)-γ in CD8+ and interleukin (IL)-12 in CD4+], Th2 (IL-4, IL-5 and IL-13 in CD4+) and Th17 (IL-17 in CD4+). Interestingly, AdC7OprF.RGD induced more robust protective immunity against pulmonary infection with P. aeruginosa compared to AdC7OprF or the control Ad5 vectors. The enhanced protective immunity induced by AdC7OprF.RGD was maintained in the absence of alveolar macrophages (AM) or CD1d natural killer T cells. Together, the data suggest that addition of RGD to the fibre of an AdC7-based vaccine is useful to enhance its mucosal protective immunogenicity. PMID:23607394

Attenuated Human Parainfluenza Virus Type 1 Expressing the Respiratory Syncytial Virus (RSV) Fusion (F) Glycoprotein from an Added Gene: Effects of Prefusion Stabilization and Packaging of RSV F.

PubMed

Liu, Xiang; Liang, Bo; Ngwuta, Joan; Liu, Xueqiao; Surman, Sonja; Lingemann, Matthias; Kwong, Peter D; Graham, Barney S; Collins, Peter L; Munir, Shirin

2017-11-15

Human respiratory syncytial virus (RSV) is the most prevalent worldwide cause of severe respiratory tract infection in infants and young children. Human parainfluenza virus type 1 (HPIV1) also causes severe pediatric respiratory illness, especially croup. Both viruses lack vaccines. Here, we describe the preclinical development of a bivalent RSV/HPIV1 vaccine based on a recombinant HPIV1 vector, attenuated by a stabilized mutation, that expresses RSV F protein modified for increased stability in the prefusion (pre-F) conformation by previously described disulfide bond (DS) and hydrophobic cavity-filling (Cav1) mutations. RSV F was expressed from the first or second gene position as the full-length protein or as a chimeric protein with its transmembrane and cytoplasmic tail (TMCT) domains substituted with those of HPIV1 F in an effort to direct packaging in the vector particles. All constructs were recovered by reverse genetics. The TMCT versions of RSV F were packaged in the rHPIV1 particles much more efficiently than their full-length counterparts. In hamsters, the presence of the RSV F gene, and in particular the TMCT versions, was attenuating and resulted in reduced immunogenicity. However, the vector expressing full-length RSV F from the pre-N position was immunogenic for RSV and HPIV1. It conferred complement-independent high-quality RSV-neutralizing antibodies at titers similar to those of wild-type RSV and provided protection against RSV challenge. The vectors exhibited stable RSV F expression in vitro and in vivo In conclusion, an attenuated rHPIV1 vector expressing a pre-F-stabilized form of RSV F demonstrated promising immunogenicity and should be further developed as an intranasal pediatric vaccine. IMPORTANCE RSV and HPIV1 are major viral causes of acute pediatric respiratory illness for which no vaccines or suitable antiviral drugs are available. The RSV F glycoprotein is the major RSV neutralization antigen. We used a rHPIV1 vector, bearing a stabilized attenuating mutation, to express the RSV F glycoprotein bearing amino acid substitutions that increase its stability in the pre-F form, the most immunogenic form that elicits highly functional virus-neutralizing antibodies. RSV F was expressed from the pre-N or N-P gene position of the rHPIV1 vector as a full-length protein or as a chimeric form with its TMCT domain derived from HPIV1 F. TMCT modification greatly increased packaging of RSV F into the vector particles but also increased vector attenuation in vivo , resulting in reduced immunogenicity. In contrast, full-length RSV F expressed from the pre-N position was immunogenic, eliciting complement-independent RSV-neutralizing antibodies and providing protection against RSV challenge. Copyright © 2017 American Society for Microbiology.

"Analytical" vector-functions I

NASA Astrophysics Data System (ADS)

Todorov, Vladimir Todorov

2017-12-01

In this note we try to give a new (or different) approach to the investigation of analytical vector functions. More precisely a notion of a power xn; n ∈ ℕ+ of a vector x ∈ ℝ3 is introduced which allows to define an "analytical" function f : ℝ3 → ℝ3. Let furthermore f (ξ )= ∑n =0 ∞ anξn be an analytical function of the real variable ξ. Here we replace the power ξn of the number ξ with the power of a vector x ∈ ℝ3 to obtain a vector "power series" f (x )= ∑n =0 ∞ anxn . We research some properties of the vector series as well as some applications of this idea. Note that an "analytical" vector function does not depend of any basis, which may be used in research into some problems in physics.

Angular dependence of primordial trispectra and CMB spectral distortions

NASA Astrophysics Data System (ADS)

Shiraishi, Maresuke; Bartolo, Nicola; Liguori, Michele

2016-10-01

Under the presence of anisotropic sources in the inflationary era, the trispectrum of the primordial curvature perturbation has a very specific angular dependence between each wavevector that is distinguishable from the one encountered when only scalar fields are present, characterized by an angular dependence described by Legendre polynomials. We examine the imprints left by curvature trispectra on the TTμ bispectrum, generated by the correlation between temperature anisotropies (T) and chemical potential spectral distortions (μ) of the Cosmic Microwave Background (CMB). Due to the angular dependence of the primordial signal, the corresponding TTμ bispectrum strongly differs in shape from TTμ sourced by the usual gNL or τNL local trispectra, enabling us to obtain an unbiased estimation. From a Fisher matrix analysis, we find that, in a cosmic-variance-limited (CVL) survey of TTμ, a minimum detectable value of the quadrupolar Legendre coefficient is d2 ~ 0.01, which is 4 orders of magnitude better than the best value attainable from the TTTT CMB trispectrum. In the case of an anisotropic inflationary model with a f(phi)F2 interaction (coupling the inflaton field phi with a vector kinetic term F2), the size of the curvature trispectrum is related to that of quadrupolar power spectrum asymmetry, g*. In this case, a CVL measurement of TTμ makes it possible to measure g* down to 10-3.

Multivariable control altitude demonstration on the F100 turbofan engine

NASA Technical Reports Server (NTRS)

Lehtinen, B.; Dehoff, R. L.; Hackney, R. D.

1979-01-01

The F100 Multivariable control synthesis (MVCS) program, was aimed at demonstrating the benefits of LGR synthesis theory in the design of a multivariable engine control system for operation throughout the flight envelope. The advantages of such procedures include: (1) enhanced performance from cross-coupled controls, (2) maximum use of engine variable geometry, and (3) a systematic design procedure that can be applied efficiently to new engine systems. The control system designed, under the MVCS program, for the Pratt & Whitney F100 turbofan engine is described. Basic components of the control include: (1) a reference value generator for deriving a desired equilibrium state and an approximate control vector, (2) a transition model to produce compatible reference point trajectories during gross transients, (3) gain schedules for producing feedback terms appropriate to the flight condition, and (4) integral switching logic to produce acceptable steady-state performance without engine operating limit exceedance.

Light weakly coupled axial forces: models, constraints, and projections

DOE PAGES

Kahn, Yonatan; Krnjaic, Gordan; Mishra-Sharma, Siddharth; ...

2017-05-01

Here, we investigate the landscape of constraints on MeV-GeV scale, hidden U(1) forces with nonzero axial-vector couplings to Standard Model fermions. While the purely vector-coupled dark photon, which may arise from kinetic mixing, is a well-motivated scenario, several MeV-scale anomalies motivate a theory with axial couplings which can be UV-completed consistent with Standard Model gauge invariance. Moreover, existing constraints on dark photons depend on products of various combinations of axial and vector couplings, making it difficult to isolate the e ects of axial couplings for particular flavors of SM fermions. We present a representative renormalizable, UV-complete model of a darkmore » photon with adjustable axial and vector couplings, discuss its general features, and show how some UV constraints may be relaxed in a model with nonrenormalizable Yukawa couplings at the expense of fine-tuning. We survey the existing parameter space and the projected reach of planned experiments, brie y commenting on the relevance of the allowed parameter space to low-energy anomalies in π 0 and 8Be* decay.« less

Light weakly coupled axial forces: models, constraints, and projections

DOE Office of Scientific and Technical Information (OSTI.GOV)

Kahn, Yonatan; Krnjaic, Gordan; Mishra-Sharma, Siddharth

Here, we investigate the landscape of constraints on MeV-GeV scale, hidden U(1) forces with nonzero axial-vector couplings to Standard Model fermions. While the purely vector-coupled dark photon, which may arise from kinetic mixing, is a well-motivated scenario, several MeV-scale anomalies motivate a theory with axial couplings which can be UV-completed consistent with Standard Model gauge invariance. Moreover, existing constraints on dark photons depend on products of various combinations of axial and vector couplings, making it difficult to isolate the e ects of axial couplings for particular flavors of SM fermions. We present a representative renormalizable, UV-complete model of a darkmore » photon with adjustable axial and vector couplings, discuss its general features, and show how some UV constraints may be relaxed in a model with nonrenormalizable Yukawa couplings at the expense of fine-tuning. We survey the existing parameter space and the projected reach of planned experiments, brie y commenting on the relevance of the allowed parameter space to low-energy anomalies in π 0 and 8Be* decay.« less

Search for Tensor, Vector, and Scalar Polarizations in the Stochastic Gravitational-Wave Background

NASA Astrophysics Data System (ADS)

Abbott, B. P.; Abbott, R.; Abbott, T. D.; Acernese, F.; Ackley, K.; Adams, C.; Adams, T.; Addesso, P.; Adhikari, R. X.; Adya, V. B.; Affeldt, C.; Afrough, M.; Agarwal, B.; Agathos, M.; Agatsuma, K.; Aggarwal, N.; Aguiar, O. D.; Aiello, L.; Ain, A.; Ajith, P.; Allen, B.; Allen, G.; Allocca, A.; Altin, P. A.; Amato, A.; Ananyeva, A.; Anderson, S. B.; Anderson, W. G.; Angelova, S. V.; Antier, S.; Appert, S.; Arai, K.; Araya, M. C.; Areeda, J. S.; Arnaud, N.; Ascenzi, S.; Ashton, G.; Ast, M.; Aston, S. M.; Astone, P.; Atallah, D. V.; Aufmuth, P.; Aulbert, C.; AultONeal, K.; Austin, C.; Avila-Alvarez, A.; Babak, S.; Bacon, P.; Bader, M. K. M.; Bae, S.; Baker, P. T.; Baldaccini, F.; Ballardin, G.; Ballmer, S. W.; Banagiri, S.; Barayoga, J. C.; Barclay, S. E.; Barish, B. C.; Barker, D.; Barkett, K.; Barone, F.; Barr, B.; Barsotti, L.; Barsuglia, M.; Barta, D.; Bartlett, J.; Bartos, I.; Bassiri, R.; Basti, A.; Batch, J. C.; Bawaj, M.; Bayley, J. C.; Bazzan, M.; Bécsy, B.; Beer, C.; Bejger, M.; Belahcene, I.; Bell, A. S.; Berger, B. K.; Bergmann, G.; Bero, J. J.; Berry, C. P. L.; Bersanetti, D.; Bertolini, A.; Betzwieser, J.; Bhagwat, S.; Bhandare, R.; Bilenko, I. A.; Billingsley, G.; Billman, C. R.; Birch, J.; Birney, R.; Birnholtz, O.; Biscans, S.; Biscoveanu, S.; Bisht, A.; Bitossi, M.; Biwer, C.; Bizouard, M. A.; Blackburn, J. K.; Blackman, J.; Blair, C. D.; Blair, D. G.; Blair, R. M.; Bloemen, S.; Bock, O.; Bode, N.; Boer, M.; Bogaert, G.; Bohe, A.; Bondu, F.; Bonilla, E.; Bonnand, R.; Boom, B. A.; Bork, R.; Boschi, V.; Bose, S.; Bossie, K.; Bouffanais, Y.; Bozzi, A.; Bradaschia, C.; Brady, P. R.; Branchesi, M.; Brau, J. E.; Briant, T.; Brillet, A.; Brinkmann, M.; Brisson, V.; Brockill, P.; Broida, J. E.; Brooks, A. F.; Brown, D. A.; Brown, D. D.; Brunett, S.; Buchanan, C. C.; Buikema, A.; Bulik, T.; Bulten, H. J.; Buonanno, A.; Buskulic, D.; Buy, C.; Byer, R. L.; Cabero, M.; Cadonati, L.; Cagnoli, G.; Cahillane, C.; Calderón Bustillo, J.; Callister, T. A.; Calloni, E.; Camp, J. B.; Canepa, M.; Canizares, P.; Cannon, K. C.; Cao, H.; Cao, J.; Capano, C. D.; Capocasa, E.; Carbognani, F.; Caride, S.; Carney, M. F.; Diaz, J. Casanueva; Casentini, C.; Caudill, S.; Cavaglià, M.; Cavalier, F.; Cavalieri, R.; Cella, G.; Cepeda, C. B.; Cerdá-Durán, P.; Cerretani, G.; Cesarini, E.; Chamberlin, S. J.; Chan, M.; Chao, S.; Charlton, P.; Chase, E.; Chassande-Mottin, E.; Chatterjee, D.; Cheeseboro, B. D.; Chen, H. Y.; Chen, X.; Chen, Y.; Cheng, H.-P.; Chia, H.; Chincarini, A.; Chiummo, A.; Chmiel, T.; Cho, H. S.; Cho, M.; Chow, J. H.; Christensen, N.; Chu, Q.; Chua, A. J. K.; Chua, S.; Chung, A. K. W.; Chung, S.; Ciani, G.; Ciolfi, R.; Cirelli, C. E.; Cirone, A.; Clara, F.; Clark, J. A.; Clearwater, P.; Cleva, F.; Cocchieri, C.; Coccia, E.; Cohadon, P.-F.; Cohen, D.; Colla, A.; Collette, C. G.; Cominsky, L. R.; Constancio, M.; Conti, L.; Cooper, S. J.; Corban, P.; Corbitt, T. R.; Cordero-Carrión, I.; Corley, K. R.; Cornish, N.; Corsi, A.; Cortese, S.; Costa, C. A.; Coughlin, E.; Coughlin, M. W.; Coughlin, S. B.; Coulon, J.-P.; Countryman, S. T.; Couvares, P.; Covas, P. B.; Cowan, E. E.; Coward, D. M.; Cowart, M. J.; Coyne, D. C.; Coyne, R.; Creighton, J. D. E.; Creighton, T. D.; Cripe, J.; Crowder, S. G.; Cullen, T. J.; Cumming, A.; Cunningham, L.; Cuoco, E.; Canton, T. Dal; Dálya, G.; Danilishin, S. L.; D'Antonio, S.; Danzmann, K.; Dasgupta, A.; Da Silva Costa, C. F.; Dattilo, V.; Dave, I.; Davier, M.; Davis, D.; Daw, E. J.; Day, B.; De, S.; DeBra, D.; Degallaix, J.; De Laurentis, M.; Deléglise, S.; Del Pozzo, W.; Demos, N.; Denker, T.; Dent, T.; De Pietri, R.; Dergachev, V.; De Rosa, R.; DeRosa, R. T.; De Rossi, C.; DeSalvo, R.; de Varona, O.; Devenson, J.; Dhurandhar, S.; Díaz, M. C.; Di Fiore, L.; Di Giovanni, M.; Di Girolamo, T.; Di Lieto, A.; Di Pace, S.; Di Palma, I.; Di Renzo, F.; Doctor, Z.; Dolique, V.; Donovan, F.; Dooley, K. L.; Doravari, S.; Dorrington, I.; Douglas, R.; Dovale Álvarez, M.; Downes, T. P.; Drago, M.; Dreissigacker, C.; Driggers, J. C.; Du, Z.; Ducrot, M.; Dupej, P.; Dwyer, S. E.; Edo, T. B.; Edwards, M. C.; Effler, A.; Eggenstein, H.-B.; Ehrens, P.; Eichholz, J.; Eikenberry, S. S.; Eisenstein, R. A.; Essick, R. C.; Estevez, D.; Etienne, Z. B.; Etzel, T.; Evans, M.; Evans, T. M.; Factourovich, M.; Fafone, V.; Fair, H.; Fairhurst, S.; Fan, X.; Farinon, S.; Farr, B.; Farr, W. M.; Fauchon-Jones, E. J.; Favata, M.; Fays, M.; Fee, C.; Fehrmann, H.; Feicht, J.; Fejer, M. M.; Fernandez-Galiana, A.; Ferrante, I.; Ferreira, E. C.; Ferrini, F.; Fidecaro, F.; Finstad, D.; Fiori, I.; Fiorucci, D.; Fishbach, M.; Fisher, R. P.; Fitz-Axen, M.; Flaminio, R.; Fletcher, M.; Fong, H.; Font, J. A.; Forsyth, P. W. F.; Forsyth, S. S.; Fournier, J.-D.; Frasca, S.; Frasconi, F.; Frei, Z.; Freise, A.; Frey, R.; Frey, V.; Fries, E. M.; Fritschel, P.; Frolov, V. V.; Fulda, P.; Fyffe, M.; Gabbard, H.; Gadre, B. U.; Gaebel, S. M.; Gair, J. R.; Gammaitoni, L.; Ganija, M. R.; Gaonkar, S. G.; Garcia-Quiros, C.; Garufi, F.; Gateley, B.; Gaudio, S.; Gaur, G.; Gayathri, V.; Gehrels, N.; Gemme, G.; Genin, E.; Gennai, A.; George, D.; George, J.; Gergely, L.; Germain, V.; Ghonge, S.; Ghosh, Abhirup; Ghosh, Archisman; Ghosh, S.; Giaime, J. A.; Giardina, K. D.; Giazotto, A.; Gill, K.; Glover, L.; Goetz, E.; Goetz, R.; Gomes, S.; Goncharov, B.; González, G.; Gonzalez Castro, J. M.; Gopakumar, A.; Gorodetsky, M. L.; Gossan, S. E.; Gosselin, M.; Gouaty, R.; Grado, A.; Graef, C.; Granata, M.; Grant, A.; Gras, S.; Gray, C.; Greco, G.; Green, A. C.; Gretarsson, E. M.; Groot, P.; Grote, H.; Grunewald, S.; Gruning, P.; Guidi, G. M.; Guo, X.; Gupta, A.; Gupta, M. K.; Gushwa, K. E.; Gustafson, E. K.; Gustafson, R.; Halim, O.; Hall, B. R.; Hall, E. D.; Hamilton, E. Z.; Hammond, G.; Haney, M.; Hanke, M. M.; Hanks, J.; Hanna, C.; Hannam, M. D.; Hannuksela, O. A.; Hanson, J.; Hardwick, T.; Harms, J.; Harry, G. M.; Harry, I. W.; Hart, M. J.; Haster, C.-J.; Haughian, K.; Healy, J.; Heidmann, A.; Heintze, M. C.; Heitmann, H.; Hello, P.; Hemming, G.; Hendry, M.; Heng, I. S.; Hennig, J.; Heptonstall, A. W.; Heurs, M.; Hild, S.; Hinderer, T.; Hoak, D.; Hofman, D.; Holt, K.; Holz, D. E.; Hopkins, P.; Horst, C.; Hough, J.; Houston, E. A.; Howell, E. J.; Hreibi, A.; Hu, Y. M.; Huerta, E. A.; Huet, D.; Hughey, B.; Husa, S.; Huttner, S. H.; Huynh-Dinh, T.; Indik, N.; Inta, R.; Intini, G.; Isa, H. N.; Isac, J.-M.; Isi, M.; Iyer, B. R.; Izumi, K.; Jacqmin, T.; Jani, K.; Jaranowski, P.; Jawahar, S.; Jiménez-Forteza, F.; Johnson, W. W.; Jones, D. I.; Jones, R.; Jonker, R. J. G.; Ju, L.; Junker, J.; Kalaghatgi, C. V.; Kalogera, V.; Kamai, B.; Kandhasamy, S.; Kang, G.; Kanner, J. B.; Kapadia, S. J.; Karki, S.; Karvinen, K. S.; Kasprzack, M.; Katolik, M.; Katsavounidis, E.; Katzman, W.; Kaufer, S.; Kawabe, K.; Kéfélian, F.; Keitel, D.; Kemball, A. J.; Kennedy, R.; Kent, C.; Key, J. S.; Khalili, F. Y.; Khan, I.; Khan, S.; Khan, Z.; Khazanov, E. A.; Kijbunchoo, N.; Kim, Chunglee; Kim, J. C.; Kim, K.; Kim, W.; Kim, W. S.; Kim, Y.-M.; Kimbrell, S. J.; King, E. J.; King, P. J.; Kinley-Hanlon, M.; Kirchhoff, R.; Kissel, J. S.; Kleybolte, L.; Klimenko, S.; Knowles, T. D.; Koch, P.; Koehlenbeck, S. M.; Koley, S.; Kondrashov, V.; Kontos, A.; Korobko, M.; Korth, W. Z.; Kowalska, I.; Kozak, D. B.; Krämer, C.; Kringel, V.; Królak, A.; Kuehn, G.; Kumar, P.; Kumar, R.; Kumar, S.; Kuo, L.; Kutynia, A.; Kwang, S.; Lackey, B. D.; Lai, K. H.; Landry, M.; Lang, R. N.; Lange, J.; Lantz, B.; Lanza, R. K.; Lartaux-Vollard, A.; Lasky, P. D.; Laxen, M.; Lazzarini, A.; Lazzaro, C.; Leaci, P.; Leavey, S.; Lee, C. H.; Lee, H. K.; Lee, H. M.; Lee, H. W.; Lee, K.; Lehmann, J.; Lenon, A.; Leonardi, M.; Leroy, N.; Letendre, N.; Levin, Y.; Li, T. G. F.; Linker, S. D.; Littenberg, T. B.; Liu, J.; Lo, R. K. L.; Lockerbie, N. A.; London, L. T.; Lord, J. E.; Lorenzini, M.; Loriette, V.; Lormand, M.; Losurdo, G.; Lough, J. D.; Lousto, C. O.; Lovelace, G.; Lück, H.; Lumaca, D.; Lundgren, A. P.; Lynch, R.; Ma, Y.; Macas, R.; Macfoy, S.; Machenschalk, B.; MacInnis, M.; Macleod, D. M.; Magaña Hernandez, I.; Magaña-Sandoval, F.; Magaña Zertuche, L.; Magee, R. M.; Majorana, E.; Maksimovic, I.; Man, N.; Mandic, V.; Mangano, V.; Mansell, G. L.; Manske, M.; Mantovani, M.; Marchesoni, F.; Marion, F.; Márka, S.; Márka, Z.; Markakis, C.; Markosyan, A. S.; Markowitz, A.; Maros, E.; Marquina, A.; Martelli, F.; Martellini, L.; Martin, I. W.; Martin, R. M.; Martynov, D. V.; Mason, K.; Massera, E.; Masserot, A.; Massinger, T. J.; Masso-Reid, M.; Mastrogiovanni, S.; Matas, A.; Matichard, F.; Matone, L.; Mavalvala, N.; Mazumder, N.; McCarthy, R.; McClelland, D. E.; McCormick, S.; McCuller, L.; McGuire, S. C.; McIntyre, G.; McIver, J.; McManus, D. J.; McNeill, L.; McRae, T.; McWilliams, S. T.; Meacher, D.; Meadors, G. D.; Mehmet, M.; Meidam, J.; Mejuto-Villa, E.; Melatos, A.; Mendell, G.; Mercer, R. A.; Merilh, E. L.; Merzougui, M.; Meshkov, S.; Messenger, C.; Messick, C.; Metzdorff, R.; Meyers, P. M.; Miao, H.; Michel, C.; Middleton, H.; Mikhailov, E. E.; Milano, L.; Miller, A. L.; Miller, B. B.; Miller, J.; Millhouse, M.; Milovich-Goff, M. C.; Minazzoli, O.; Minenkov, Y.; Ming, J.; Mishra, C.; Mitra, S.; Mitrofanov, V. P.; Mitselmakher, G.; Mittleman, R.; Moffa, D.; Moggi, A.; Mogushi, K.; Mohan, M.; Mohapatra, S. R. P.; Montani, M.; Moore, C. J.; Moraru, D.; Moreno, G.; Morriss, S. R.; Mours, B.; Mow-Lowry, C. M.; Mueller, G.; Muir, A. W.; Mukherjee, Arunava; Mukherjee, D.; Mukherjee, S.; Mukund, N.; Mullavey, A.; Munch, J.; Muñiz, E. A.; Muratore, M.; Murray, P. G.; Napier, K.; Nardecchia, I.; Naticchioni, L.; Nayak, R. K.; Neilson, J.; Nelemans, G.; Nelson, T. J. N.; Nery, M.; Neunzert, A.; Nevin, L.; Newport, J. M.; Newton, G.; Ng, K. K. Y.; Nguyen, T. T.; Nichols, D.; Nielsen, A. B.; Nissanke, S.; Nitz, A.; Noack, A.; Nocera, F.; Nolting, D.; North, C.; Nuttall, L. K.; Oberling, J.; O'Dea, G. D.; Ogin, G. H.; Oh, J. J.; Oh, S. H.; Ohme, F.; Okada, M. A.; Oliver, M.; Oppermann, P.; Oram, Richard J.; O'Reilly, B.; Ormiston, R.; Ortega, L. F.; O'Shaughnessy, R.; Ossokine, S.; Ottaway, D. J.; Overmier, H.; Owen, B. J.; Pace, A. E.; Page, J.; Page, M. A.; Pai, A.; Pai, S. A.; Palamos, J. R.; Palashov, O.; Palomba, C.; Pal-Singh, A.; Pan, Howard; Pan, Huang-Wei; Pang, B.; Pang, P. T. H.; Pankow, C.; Pannarale, F.; Pant, B. C.; Paoletti, F.; Paoli, A.; Papa, M. A.; Parida, A.; Parker, W.; Pascucci, D.; Pasqualetti, A.; Passaquieti, R.; Passuello, D.; Patil, M.; Patricelli, B.; Pearlstone, B. L.; Pedraza, M.; Pedurand, R.; Pekowsky, L.; Pele, A.; Penn, S.; Perez, C. J.; Perreca, A.; Perri, L. M.; Pfeiffer, H. P.; Phelps, M.; Piccinni, O. J.; Pichot, M.; Piergiovanni, F.; Pierro, V.; Pillant, G.; Pinard, L.; Pinto, I. M.; Pirello, M.; Pitkin, M.; Poe, M.; Poggiani, R.; Popolizio, P.; Porter, E. K.; Post, A.; Powell, J.; Prasad, J.; Pratt, J. W. W.; Pratten, G.; Predoi, V.; Prestegard, T.; Prijatelj, M.; Principe, M.; Privitera, S.; Prodi, G. A.; Prokhorov, L. G.; Puncken, O.; Punturo, M.; Puppo, P.; Pürrer, M.; Qi, H.; Quetschke, V.; Quintero, E. A.; Quitzow-James, R.; Raab, F. J.; Rabeling, D. S.; Radkins, H.; Raffai, P.; Raja, S.; Rajan, C.; Rajbhandari, B.; Rakhmanov, M.; Ramirez, K. E.; Ramos-Buades, A.; Rapagnani, P.; Raymond, V.; Razzano, M.; Read, J.; Regimbau, T.; Rei, L.; Reid, S.; Reitze, D. H.; Ren, W.; Reyes, S. D.; Ricci, F.; Ricker, P. M.; Rieger, S.; Riles, K.; Rizzo, M.; Robertson, N. A.; Robie, R.; Robinet, F.; Rocchi, A.; Rolland, L.; Rollins, J. G.; Roma, V. J.; Romano, J. D.; Romano, R.; Romel, C. L.; Romie, J. H.; Rosińska, D.; Ross, M. P.; Rowan, S.; Rüdiger, A.; Ruggi, P.; Rutins, G.; Ryan, K.; Sachdev, S.; Sadecki, T.; Sadeghian, L.; Sakellariadou, M.; Salconi, L.; Saleem, M.; Salemi, F.; Samajdar, A.; Sammut, L.; Sampson, L. M.; Sanchez, E. J.; Sanchez, L. E.; Sanchis-Gual, N.; Sandberg, V.; Sanders, J. R.; Sassolas, B.; Saulson, P. R.; Sauter, O.; Savage, R. L.; Sawadsky, A.; Schale, P.; Scheel, M.; Scheuer, J.; Schmidt, J.; Schmidt, P.; Schnabel, R.; Schofield, R. M. S.; Schönbeck, A.; Schreiber, E.; Schuette, D.; Schulte, B. W.; Schutz, B. F.; Schwalbe, S. G.; Scott, J.; Scott, S. M.; Seidel, E.; Sellers, D.; Sengupta, A. S.; Sentenac, D.; Sequino, V.; Sergeev, A.; Shaddock, D. A.; Shaffer, T. J.; Shah, A. A.; Shahriar, M. S.; Shaner, M. B.; Shao, L.; Shapiro, B.; Shawhan, P.; Sheperd, A.; Shoemaker, D. H.; Shoemaker, D. M.; Siellez, K.; Siemens, X.; Sieniawska, M.; Sigg, D.; Silva, A. D.; Singer, L. P.; Singh, A.; Singhal, A.; Sintes, A. M.; Slagmolen, B. J. J.; Smith, B.; Smith, J. R.; Smith, R. J. E.; Somala, S.; Son, E. J.; Sonnenberg, J. A.; Sorazu, B.; Sorrentino, F.; Souradeep, T.; Spencer, A. P.; Srivastava, A. K.; Staats, K.; Staley, A.; Steinke, M.; Steinlechner, J.; Steinlechner, S.; Steinmeyer, D.; Stevenson, S. P.; Stone, R.; Stops, D. J.; Strain, K. A.; Stratta, G.; Strigin, S. E.; Strunk, A.; Sturani, R.; Stuver, A. L.; Summerscales, T. Z.; Sun, L.; Sunil, S.; Suresh, J.; Sutton, P. J.; Swinkels, B. L.; Szczepańczyk, M. J.; Tacca, M.; Tait, S. C.; Talbot, C.; Talukder, D.; Tanner, D. B.; Tao, D.; Tápai, M.; Taracchini, A.; Tasson, J. D.; Taylor, J. A.; Taylor, R.; Tewari, S. V.; Theeg, T.; Thies, F.; Thomas, E. G.; Thomas, M.; Thomas, P.; Thorne, K. A.; Thrane, E.; Tiwari, S.; Tiwari, V.; Tokmakov, K. V.; Toland, K.; Tonelli, M.; Tornasi, Z.; Torres-Forné, A.; Torrie, C. I.; Töyrä, D.; Travasso, F.; Traylor, G.; Trinastic, J.; Tringali, M. C.; Trozzo, L.; Tsang, K. W.; Tse, M.; Tso, R.; Tsukada, L.; Tsuna, D.; Tuyenbayev, D.; Ueno, K.; Ugolini, D.; Unnikrishnan, C. S.; Urban, A. L.; Usman, S. A.; Vahlbruch, H.; Vajente, G.; Valdes, G.; van Bakel, N.; van Beuzekom, M.; van den Brand, J. F. J.; Van Den Broeck, C.; Vander-Hyde, D. C.; van der Schaaf, L.; van Heijningen, J. V.; van Veggel, A. A.; Vardaro, M.; Varma, V.; Vass, S.; Vasúth, M.; Vecchio, A.; Vedovato, G.; Veitch, J.; Veitch, P. J.; Venkateswara, K.; Venugopalan, G.; Verkindt, D.; Vetrano, F.; Viceré, A.; Viets, A. D.; Vinciguerra, S.; Vine, D. J.; Vinet, J.-Y.; Vitale, S.; Vo, T.; Vocca, H.; Vorvick, C.; Vyatchanin, S. P.; Wade, A. R.; Wade, L. E.; Wade, M.; Walet, R.; Walker, M.; Wallace, L.; Walsh, S.; Wang, G.; Wang, H.; Wang, J. Z.; Wang, W. H.; Wang, Y. F.; Ward, R. L.; Warner, J.; Was, M.; Watchi, J.; Weaver, B.; Wei, L.-W.; Weinert, M.; Weinstein, A. J.; Weiss, R.; Wen, L.; Wessel, E. K.; Weßels, P.; Westerweck, J.; Westphal, T.; Wette, K.; Whelan, J. T.; Whiting, B. F.; Whittle, C.; Wilken, D.; Williams, D.; Williams, R. D.; Williamson, A. R.; Willis, J. L.; Willke, B.; Wimmer, M. H.; Winkler, W.; Wipf, C. C.; Wittel, H.; Woan, G.; Woehler, J.; Wofford, J.; Wong, K. W. K.; Worden, J.; Wright, J. L.; Wu, D. S.; Wysocki, D. M.; Xiao, S.; Yamamoto, H.; Yancey, C. C.; Yang, L.; Yap, M. J.; Yazback, M.; Yu, Hang; Yu, Haocun; Yvert, M.; ZadroŻny, A.; Zanolin, M.; Zelenova, T.; Zendri, J.-P.; Zevin, M.; Zhang, L.; Zhang, M.; Zhang, T.; Zhang, Y.-H.; Zhao, C.; Zhou, M.; Zhou, Z.; Zhu, S. J.; Zhu, X. J.; Zucker, M. E.; Zweizig, J.; LIGO Scientific Collaboration; Virgo Collaboration

2018-05-01

The detection of gravitational waves with Advanced LIGO and Advanced Virgo has enabled novel tests of general relativity, including direct study of the polarization of gravitational waves. While general relativity allows for only two tensor gravitational-wave polarizations, general metric theories can additionally predict two vector and two scalar polarizations. The polarization of gravitational waves is encoded in the spectral shape of the stochastic gravitational-wave background, formed by the superposition of cosmological and individually unresolved astrophysical sources. Using data recorded by Advanced LIGO during its first observing run, we search for a stochastic background of generically polarized gravitational waves. We find no evidence for a background of any polarization, and place the first direct bounds on the contributions of vector and scalar polarizations to the stochastic background. Under log-uniform priors for the energy in each polarization, we limit the energy densities of tensor, vector, and scalar modes at 95% credibility to Ω0T<5.58 ×10-8 , Ω0V<6.35 ×10-8 , and Ω0S<1.08 ×10-7 at a reference frequency f0=25 Hz .

Single-dose replication-defective VSV-based Nipah virus vaccines provide protection from lethal challenge in Syrian hamsters.

PubMed

Lo, Michael K; Bird, Brian H; Chattopadhyay, Anasuya; Drew, Clifton P; Martin, Brock E; Coleman, Joann D; Rose, John K; Nichol, Stuart T; Spiropoulou, Christina F

2014-01-01

Nipah virus (NiV) continues to cause outbreaks of fatal human encephalitis due to spillover from its bat reservoir. We determined that a single dose of replication-defective vesicular stomatitis virus (VSV)-based vaccine vectors expressing either the NiV fusion (F) or attachment (G) glycoproteins protected hamsters from over 1000 times LD50 NiV challenge. This highly effective single-dose protection coupled with an enhanced safety profile makes these candidates ideal for potential use in livestock and humans. Published by Elsevier B.V.

Use of Forward Scattering Particle Image Velocimetry to Quantify a Flow Field Near a Fully Submerged Tension Leg Platform in the Presence of Waves

DTIC Science & Technology

2012-05-01

8217’�/_’ ________ __ � J "Q. F E -3 ¥-------���-------����------------ c( -6 ------------------------------- Time (s) -9...image). Figure 5: Corrected image (left) and vector diagram (right) - wave amplitude of 5.33cm (2.1in) (Wave Crest) ·( J 20 ·0 IS ·0 10 ·0 ( j ...34 ·-0.20 ··0 " -U J ( J Figure 8: Corrected image and vector diagram - wave amplitude of -4.83cm (-1.9in) Figure 9: Corrected image and vector

Using adenovirus armed short hairpin RNA targeting transforming growth factor β1 inhibits melanoma growth and metastasis in an ex vivo animal model.

PubMed

Tai, Kuo-Feng; Wang, Chien-Hsing

2013-12-01

The transforming growth factor β (TGF-β) is the key molecule implicated in impaired immune function in human patients with malignant melanoma. TGF-β can promote tumor growth, invasion, and metastasis in advanced stages of melanoma. Blocking these tumor-promoting effects of TGF-β provides a potentially important therapeutic strategy for the treatment of melanoma. In this study, we used an adenovirus-based shRNA expression system and successfully constructed Ad/TGF-β1-RNA interference (RNAi) which mediated the RNAi for TGF-β1 gene silencing. We examined the effects of TGF-β1 protein knockdown by RNAi on the growth and metastasis of melanoma in C57BL/6 mice induced by the B16F0 cell line. The TGF-β1 hairpin oligonucleotide was cloned into adenoviral vector. The resulting recombinant adenoviruses infected murine melanoma cell line, B16F0, and designated as B16F0/TGF-β1-RNAi cells. The blank adenoviral vector also infected B16F0 cells and designed as B16F0/vector-control cells served as a control. TGF-β1 expression was reduced in B16F0/TGF-β1-RNAi cells compared with B16F0 cells and B16F0/vector-control cells. Three million wild-type B16F0 cells, B16F0/vector-control cells, and B16F0/TGF-β1-RNAi cells were injected subcutaneously into the right flanks of adult female syngeneic mice C57BL/6. The tumor sizes were 756.09 (65.35), 798.48 (78.77), and 203.55 (24.56) mm at the 14th day in the mice receiving B16F0 cells, B16F0/vector-control cells, and B16F0/TGFβ1-RNAi cells, respectively. The P value was less than 0.01 by 1-way analysis of variance. TGF-β1 knockdown in B16F0 cells enhanced the infiltration of CD4 and CD8 T cells in the tumor regions. C57BL/6 mice were evaluated for pulmonary metastasis after tail vein injection of 2 million B16F0 cells, B16F0/vector-control cells, and B16F0/TGF-β1-RNAi cells. The pulmonary metastasis also reduced significantly on days 14 day and 21 in mice injected with B16F0/TGF-β1-RNAi tumors. The blood vessel density of the tumors markedly reduced in B16F0/TGF-β1-RNAi tumors. Our results showed that Ad/TGF-β1-RNAi could induce silencing of the TGF-β1 gene effectively. Silencing of TGF-β1 expression in B16F0 cells by RNAi technology can inhibit the growth and metastasis of this tumor after being transplanted to C57BL/6 mice. This kind of adenoviral vector based on RNAi might be a promising vector for cancer therapy.

Newcastle Disease Virus Vectored Bivalent Vaccine against Virulent Infectious Bursal Disease and Newcastle Disease of Chickens

PubMed Central

Chellappa, Madhan Mohan; Pathak, Dinesh C.; Vakharia, Vikram N.

2017-01-01

Newcastle disease virus (NDV) strain F is a lentogenic vaccine strain used for primary vaccination in day-old chickens against Newcastle disease (ND) in India and Southeast Asian countries. Recombinant NDV-F virus and another recombinant NDV harboring the major capsid protein VP2 gene of a very virulent infectious bursal disease virus (IBDV); namely rNDV-F and rNDV-F/VP2, respectively, were generated using the NDV F strain. The rNDV-F/VP2 virus was slightly attenuated, as compared to the rNDV-F virus, as evidenced from the mean death time and intracerebral pathogenicity index analysis. This result indicates that rNDV-F/VP2 behaves as a lentogenic virus and it is stable even after 10 serial passages in embryonated chicken eggs. When chickens were vaccinated with the rNDV F/VP2, it induced both humoral and cell mediated immunity, and was able to confer complete protection against very virulent IBDV challenge and 80% protection against virulent NDV challenge. These results suggest that rNDV-F could be an effective and inherently safe vaccine vector. Here, we demonstrate that a bivalent NDV-IBDV vaccine candidate generated by reverse genetics method is safe, efficacious and cost-effective, which will greatly aid the poultry industry in developing countries. PMID:28954433

Center for Coastline Security Technology, Year-2

DTIC Science & Technology

2007-05-01

set to a constant value of n = 7.25 Hz (435 RPM) giving an advance ratio of J = U/nD = 0.31 (assuming a vehicle wake deficit of 0.9 UB∞ B), the yaw... noise characteristics (Case #4). Figures for Section 2.9 Figure 2.9.1: WETStar Fluorometer. Figure 2.9.2: Proposed design schematic no. 1...consecutives states and )(kw is the state noise [10]. F defines the relation between the state vector )(kX at time k and the state vector at time k

Modified Newcastle Disease virus as an improved vaccine vector against Simian Immunodeficiency virus.

PubMed

Manoharan, Vinoth K; Khattar, Sunil K; LaBranche, Celia C; Montefiori, David C; Samal, Siba K

2018-06-12

SIV infection in macaques is a relevant animal model for HIV pathogenesis and vaccine study in humans. To design a safe and effective vaccine against HIV, we evaluated the suitability of naturally-occurring avirulent Newcastle disease virus (NDV) strains and several modified versions of NDV as vectors for the expression and immunogenicity of SIV envelope protein gp160. All the NDV vectors expressed gp160 protein in infected cells. The gp160 expressed by these vectors formed oligomers and was incorporated into the NDV envelope. All the NDV vectors expressing gp160 were attenuated in chickens. Intranasal immunization of guinea pigs with modified NDV vectors such as rNDV-APMV-2CS/gp160 and rNDV-APMV-8CS/gp160 (NDV strain LaSota containing the cleavage site sequences of F protein of avian paramyxovirus (APMV) serotype 2 and 8, respectively), and rNDV-BC-F-HN/gp160 (NDV strain BC containing LaSota F cleavage site and LaSota F and HN genes) elicited improved SIV-specific humoral and mucosal immune responses compared to other NDV vectors. These modified vectors were also efficient in inducing neutralizing antibody responses to tier 1 A SIVmac251.6 and tier 1B SIVmac251/M766 strains. This study suggests that our novel modified NDV vectors are safe and immunogenic and can be used as vaccine vector to control HIV.

The Role of Conventional and Right-Sided ECG Screening for Subcutaneous ICD in a Tetralogy of Fallot Population.

PubMed

Alonso, Pau; Osca, Joaquín; Cano, Oscar; Pimenta, Pedro; Andrés, Ana; Yagüe, Jaime; Millet, José; Rueda, Joaquín; Sancho-Tello, María José

2017-02-01

Information regarding suitability for subcutaneous implantable cardioverter-defibrillator (S-ICD) implant in tetralogy of Fallot (ToF) population is scarce and needs to be further explored. (1) to determine the proportion of patients with ToF eligible for S-ICD, (2) to identify the optimal sensing vector in ToF patients, (3) to test specifically the eligibility for S-ICD with right-sided screening, and (4) to compare with the proportion of eligible patients in a nonselected ICD population. We recruited 60 consecutive patients with ToF and 40 consecutive nonselected patients. Conventional electrocardiographic screening was performed as usual. Right-sided alternative screening was studied by positioning the left arm and right arm electrodes 1 cm right lateral to the xiphoid midline. The Boston Scientific electrocardiogram (ECG) screening tool was utilized. We found a higher proportion of patients with right-sided positive screening in comparison with standard screening (77 ± 0.4% vs. 67 ± 0.4%; P < 0.0001) and a trend to higher number of appropriate leads in right-sided screening (1.3 ± 1 vs. 1.1 ± 1 ms; P = 0.07). Patients who failed the screening had a longer QRS duration and longer QT interval. Standard and right-sided screening showed a higher percent of positive patients in the control group compared to ToF patients (P < 0.001). Right-sided screening was associated with a significant 10% increase in S-ICD eligibility in ToF patients. When comparing with an acquired cardiomyopathies group, ToF showed a lower eligibility for S-ICD. The most appropriate ECG vector was the alternate vector in contrast to what is observed in the general population. © 2017 Wiley Periodicals, Inc.

On the 4D generalized Proca action for an Abelian vector field

DOE Office of Scientific and Technical Information (OSTI.GOV)

Allys, Erwan; Almeida, Juan P. Beltrán; Peter, Patrick

We summarize previous results on the most general Proca theory in 4 dimensions containing only first-order derivatives in the vector field (second-order at most in the associated Stückelberg scalar) and having only three propagating degrees of freedom with dynamics controlled by second-order equations of motion. Discussing the Hessian condition used in previous works, we conjecture that, as in the scalar galileon case, the most complete action contains only a finite number of terms with second-order derivatives of the Stückelberg field describing the longitudinal mode, which is in agreement with the results of http://dx.doi.org/10.1088/1475-7516/2014/05/015 and http://dx.doi.org/10.1016/j.physletb.2016.04.017 and complements those of http://dx.doi.org/10.1088/1475-7516/2016/02/004.more » We also correct and complete the parity violating sector, obtaining an extra term on top of the arbitrary function of the field A{sub μ}, the Faraday tensor F{sub μν} and its Hodge dual F-tilde{sub μν}.« less

Comparative Vector Bionomics and Morphometrics of Two Genetically Distinct Field Populations of Anopheles darlingi Root from Belize, Central America and Zungarococha, Peru, South America

DTIC Science & Technology

2014-01-31

Loreto Department, Peru, South America (n= 10) [log rank (Mantel-Cox) P < .001 ). 81 Total Parity Peru 100% J ’ ’ ,, ~ It ~ 90% ~, [41-liill-4...8217 ill ~ imr. T - j f f~ ’ °" ~i ._......._. ........................................ IL,..ll ..... ._.._.._.c.-mc...347’.+’V"¥.’V~"r.y.~ ~𔄃".+"f:i’" J . ~ .. ’\\--~ .. ,. t). .. t)...,,,.t)."Y"~ ~.!;’ t)...,..~ ~,, ~y ,.,. Figure 8. Percent of parous and

Inflation with a massive vector field nonminimally coupled to gravity

NASA Astrophysics Data System (ADS)

Páramos, J.

2018-01-01

The possibility that inflation is driven by a massive vector field with SO(3) global symmetry nonminimally coupled to gravity is presented. Through an appropriate Ansatz for the vector field, the behaviour of the equations of motion is studied through the ensuing dynamical system, focusing on the characterisation of the ensuing fixed points.

Inert two-Higgs-doublet model strongly coupled to a non-Abelian vector resonance

NASA Astrophysics Data System (ADS)

Rojas-Abatte, Felipe; Mora, Maria Luisa; Urbina, Jose; Zerwekh, Alfonso R.

2017-11-01

We study the possibility of a dark matter candidate having its origin in an extended Higgs sector which, at least partially, is related to a new strongly interacting sector. More concretely, we consider an i2HDM (i.e., a Type-I two Higgs doublet model supplemented with a Z2 under which the nonstandard scalar doublet is odd) based on the gauge group S U (2 )1×S U (2 )2×U (1 )Y . We assume that one of the scalar doublets and the standard fermion transform nontrivially under S U (2 )1 while the second doublet transforms under S U (2 )2. Our main hypothesis is that standard sector is weakly coupled while the gauge interactions associated to the second group is characterized by a large coupling constant. We explore the consequences of this construction for the phenomenology of the dark matter candidate and we show that the presence of the new vector resonance reduces the relic density saturation region, compared to the usual i2DHM, in the high dark matter mass range. In the collider side, we argue that the mono-Z production is the channel which offers the best chances to manifest the presence of the new vector field. We study the departures from the usual i2HDM predictions and show that the discovery of the heavy vector at the LHC is challenging even in the mono-Z channel since the typical cross sections are of the order of 10-2 fb .

Axial vector Z‧ and anomaly cancellation

NASA Astrophysics Data System (ADS)

Ismail, Ahmed; Keung, Wai-Yee; Tsao, Kuo-Hsing; Unwin, James

2017-05-01

Whilst the prospect of new Z‧ gauge bosons with only axial couplings to the Standard Model (SM) fermions is widely discussed, examples of anomaly-free renormalisable models are lacking in the literature. We look to remedy this by constructing several motivated examples. Specifically, we consider axial vectors which couple universally to all SM fermions, as well as those which are generation-specific, leptophilic, and leptophobic. Anomaly cancellation typically requires the presence of new coloured and charged chiral fermions, and we argue that in a large class of models masses of these new states are expected to be comparable to that of the axial vector. Finally, an axial vector mediator could provide a portal between SM and hidden sector states, and we also consider the possibility that the axial vector couples to dark matter. If the dark matter relic density is set due to freeze-out via the axial vector, this strongly constrains the parameter space.

Study of kinematic observables sentitive to the Higgs boson production channel in pp → Hjj process

NASA Astrophysics Data System (ADS)

Belyaev, N.; Konoplich, R.; Prokofiev, K.

2017-12-01

After the Higgs boson discovery at the LHC, a lot of additional measurements should be performed to understand in details the properties of the observed particle. These measurements include cross sections measurements, couplings measurements, studies of the interaction vertex structures etc. One of the most perspective subjects to study is the kinematics of the production jets, associated with the Higgs boson. It is demonstrated, that the kinematic correlations of such jets can be used to distinguish different production channels of Higgs boson: gluon-gluon fusion (ggF) and vector boson fusion (VBF). Such separation plays an important role because possible beyond the Standard Model contributions in ggF and VBF channels lead to different effects, which should be taken into account in searches for BSM physics.

Breakdown of the Migdal-Eliashberg theory: A determinant quantum Monte Carlo study

DOE PAGES

Esterlis, I.; Nosarzewski, B.; Huang, E. W.; ...

2018-04-02

The superconducting (SC) and charge-density-wave (CDW) susceptibilities of the two-dimensional Holstein model are computed using determinant quantum Monte Carlo, and compared with results computed using the Migdal-Eliashberg (ME) approach. We access temperatures as low as 25 times less than the Fermi energy, E F, which are still above the SC transition. We find that the SC susceptibility at low T agrees quantitatively with the ME theory up to a dimensionless electron-phonon coupling λ 0 ≈ 0.4 but deviates dramatically for larger λ 0. We find that for large λ 0 and small phonon frequency ω 0 << E F CDWmore » ordering is favored and the preferred CDW ordering vector is uncorrelated with any obvious feature of the Fermi surface.« less

Isolation of fraction no. 10 from Taenia saginata and evaluation of its specificity for the diagnosis of bovine cysticercosis.

PubMed

Geerts, S; Vervoort, T; Kumar, V; Ceulemans, F

1981-01-01

In an attempt to prove the specificity of the crude Taenia saginata antigen for the immunodiagnosis of bovine cysticercosis, a major and highly immunogenic fraction (F10), responsible for the formation of the typical "long band" reaction in immunoelectrophoresis, has been isolated from T. saginata proglottides by immunoaffinity chromatography. The immunoabsorbent was prepared by coupling a specifically raised hyperimmune serum (HIS) anti-F10 to Sepharose 4B. The purity of the isolated F10 was demonstrated by immunoprecipitation reactions. The HIS anti-F10, however, cross-reacted with several larval and adult Taenia spp. Consequently, F10 showed cross-reactions with the sera of animals infected with hydatid cysts or larval T. hydatigena. F10 also reacted with HIS anti-F5 (Echinococcus granulosus) but was shown to be non-identical with the well known F5 of E. granulosus. These data prove that F10 of T. saginata was not species-specific but showed a group specificity for the taeniid family - a situation analogous to F5 of E. granulosus.

750 GeV diphotons: implications for supersymmetric unification II

DOE PAGES

Hall, Lawrence J.; Harigaya, Keisuke; Nomura, Yasunori

2016-07-29

Perturbative supersymmetric gauge coupling unification is possible in six theories where complete SU (5) TeV-scale multiplets of vector matter account for the size of the reported 750 GeV diphoton resonance, interpreted as a singlet multiplet S=(s+ia)/√2. One of these has a full generation of vector matter and a unified gauge coupling αG ~ 1. The diphoton signal rate is enhanced by loops of vector squarks and sleptons, especially when the trilinear A couplings are large. If the SH uH d coupling is absent, both s and a can contribute to the resonance, which may then have a large apparent widthmore » if the mass splitting from s and a arises from loops of vector matter. The width depends sensitively on A parameters and phases of the vector squark and slepton masses. Vector quarks and/or squarks are expected to be in reach of the LHC. If the SH uH d coupling is present, a leads to a narrow diphoton resonance, while a second resonance with decays s → hh, W +W – , ZZ is likely to be discovered at future LHC runs. In some of the theories a non-standard origin or running of the soft parameters is required, for example involving conformal hidden sector interactions.« less

Generalized dark-bright vector soliton solution to the mixed coupled nonlinear Schrödinger equations.

PubMed

Manikandan, N; Radhakrishnan, R; Aravinthan, K

2014-08-01

We have constructed a dark-bright N-soliton solution with 4N+3 real parameters for the physically interesting system of mixed coupled nonlinear Schrödinger equations. Using this as well as an asymptotic analysis we have investigated the interaction between dark-bright vector solitons. Each colliding dark-bright one-soliton at the asymptotic limits includes more coupling parameters not only in the polarization vector but also in the amplitude part. Our present solution generalizes the dark-bright soliton in the literature with parametric constraints. By exploiting the role of such coupling parameters we are able to control certain interaction effects, namely beating, breathing, bouncing, attraction, jumping, etc., without affecting other soliton parameters. Particularly, the results of the interactions between the bound state dark-bright vector solitons reveal oscillations in their amplitudes under certain parametric choices. A similar kind of effect was also observed experimentally in the BECs. We have also characterized the solutions with complicated structure and nonobvious wrinkle to define polarization vector, envelope speed, envelope width, envelope amplitude, grayness, and complex modulation. It is interesting to identify that the polarization vector of the dark-bright one-soliton evolves on a spherical surface instead of a hyperboloid surface as in the bright-bright case of the mixed coupled nonlinear Schrödinger equations.

Production of SSM/I data sets

NASA Technical Reports Server (NTRS)

Wentz, Frank J.

1992-01-01

This Final Report is a summary of the work that was performed under Contract NAS8-38075 between NASA Marshall Space Flight Center and Remote Sensing Systems from September 1989 to September 1992. The primary accomplishment was the delivery of Special Sensor Microwave/Imager (SSM/I) data tapes containing sensor and geophysical products. In all, 515 tapes (80 gigabytes) were delivered. These tapes contained the F08 SSM/I data for the period from July 1988 through December 1991 and the F10 SSM/I data for the period from December 1990 through December 1991. For the F08 SSM/I, a data inventory was compiled and an engineering assessment was done. Ephemeris tables for the F08 and F10 spacecrafts were computed. Scientific studies on the oceanic wind vector and water vapor field were published, and color atlases of monthly ocean products were produced. This investigation was part of NASA's WETNET program.

A search for a new gauge boson A'

DOE Office of Scientific and Technical Information (OSTI.GOV)

Jensen, Eric L.

2013-08-01

In the Standard Model, gauge bosons mediate the strong, weak, and electromagnetic forces. New forces could have escaped detection only if their mediators are either heavier than order(TeV) or weakly coupled to charged matter. New vector bosons with small coupling {alpha}' arise naturally from a small kinetic mixing with the photon and have received considerable attention as an explanation of various dark matter related anomalies. Such particles can be produced in electron-nucleus fixed-target scattering and then decay to e +e -+ pairs. New light vector bosons and their associated forces are a common feature of Standard Model extensions, but existingmore » constraints are remarkably sparse. The APEX experiment will search for a new vector boson A' with coupling α'/α fs > 6 × 10 -8 to electrons in the mass range 65MeV < mass A' < 550MeV. The experiment will study e +e - production off an electron beam incident on a high-Z target in Hall A at Jefferson Lab. The e - and e + will be detected in the High Resolution Spectrometers (HRSs). The invariant mass spectrum of the e +e - pairs will be scanned for a narrow resonance corresponding to the mass of the A'. A test run for the APEX experiment was held in the summer of 2010. Using the test run data, an A' search was performed in the mass range 175-250 MeV. The search found no evidence for an A' → e +e -reaction, and set an upper limit of {alpha}'/{alpha}{sub fs} ~ 10 -6.« less

Development of Computer Program TWTVA for Calculation of 3-D Electron Trajectories in Coupled-Cavity TWTs

DTIC Science & Technology

1976-03-10

ferrule corner radius, which is typically not more than about 20). The radial mesh numbers are denoted NQR for the rf vector potential and Njyro for...the magnetic vector poten- tial matrices. Allowing for tne guard rows, the matrices run from -1 to NQR + 1, and -1 to Nj^ + 1. When the program...CR * 5» an(^ only one row ^or NCR up to 10, which covers most cases; as stated ir. the introduction, we do not expect NQR ever to exceed 20. For n

Kny Coupling Constants and Form Factors from the Chiral Bag Model

NASA Astrophysics Data System (ADS)

Jeong, M. T.; Cheon, Il-T.

2000-09-01

The form factors and coupling constants for KNΛ and KNΣ interactions have been calculated in the framework of the Chiral Bag Model with vector mesons. Taking into account vector meson (ρ, ω, K*) field effects, we find -3.88 ≤ gKNΛ ≤ -3.67 and 1.15 ≤ gKNΣ ≤ 1.24, where the quark-meson coupling constants are determined by fitting the renormalized, πNN coupling constant, [gπNN(0)]2/4π = 14.3. It is shown that vector mesons make significant contributions to the coupling constants gKNΛ and gKNΣ. Our values are existing within the experimental limits compared to the phenomenological values extracted from the kaon photo production experiments.

Black holes in vector-tensor theories

DOE Office of Scientific and Technical Information (OSTI.GOV)

Heisenberg, Lavinia; Kase, Ryotaro; Tsujikawa, Shinji

We study static and spherically symmetric black hole (BH) solutions in second-order generalized Proca theories with nonminimal vector field derivative couplings to the Ricci scalar, the Einstein tensor, and the double dual Riemann tensor. We find concrete Lagrangians which give rise to exact BH solutions by imposing two conditions of the two identical metric components and the constant norm of the vector field. These exact solutions are described by either Reissner-Nordström (RN), stealth Schwarzschild, or extremal RN solutions with a non-trivial longitudinal mode of the vector field. We then numerically construct BH solutions without imposing these conditions. For cubic andmore » quartic Lagrangians with power-law couplings which encompass vector Galileons as the specific cases, we show the existence of BH solutions with the difference between two non-trivial metric components. The quintic-order power-law couplings do not give rise to non-trivial BH solutions regular throughout the horizon exterior. The sixth-order and intrinsic vector-mode couplings can lead to BH solutions with a secondary hair. For all the solutions, the vector field is regular at least at the future or past horizon. The deviation from General Relativity induced by the Proca hair can be potentially tested by future measurements of gravitational waves in the nonlinear regime of gravity.« less

A magneto-optic technique for studying magnetization reversal processes and anisotropies applied to Co/Cu/Co trilayer structures

NASA Astrophysics Data System (ADS)

Daboo, C.; Bland, J. A. C.; Hicken, R. J.; Ives, A. J. R.; Baird, M. J.; Walker, M. J.

1993-05-01

We report the magnetization reversal and magnetic anisotropy behavior of ultrathin Co/Cu(111)/Co (dCu=20 and 27 Å) trilayer structures prepared by MBE on a 500-Å Ge/GaAs(110) epilayer. We describe an arrangement in which the magnetization components parallel and perpendicular to the applied field are both determined from longitudinal MOKE measurements. For the samples examined, coherent rotation of the magnetization vector is observed when the magnetic field is applied along the hard in-plane anisotropy axis, with the magnitude of the magnetization vector constant and close to its bulk value. Results of micromagnetic calculations closely reproduce the observed parallel and perpendicular magnetization loops, and yield strong uniaxial magnetic anisotropies in both layers while the interlayer coupling appears to be absent or negligible in comparison with the anisotropy strengths. An absence of antiferromagnetic (AF) coupling has been observed previously [W. F. Egelhoff, Jr. and M. T. Kief, Phys. Rev. B 45, 7795 (1992)] in contrast to recent results, indicating that AF coupling [M. T. Johnson et al., Phys. Rev. Lett. 69, 969 (1992)] and GMR [D. Grieg et al., J. Magn. Magn. Mater. 110, L239 (1992)] can occur in Co/Cu(111)/Co structures grown by MBE, but these properties are sensitively dependent on growth conditions. The absence of coupling in our samples is attributed to the presence of a significant interface roughness induced by the Ge epilayer. The uniaxial anisotropies are assumed to arise from strain or defects induced in the film.

Inorganic nanotubes reinforced polyvinylidene fluoride composites as low-cost electromagnetic interference shielding materials

PubMed Central

2011-01-01

Novel polymer nanocomposites comprising of MnO2 nanotubes (MNTs), functionalized multiwalled carbon nanotubes (f-MWCNTs), and polyvinylidene fluoride (PVDF) were synthesized. Homogeneous distribution of f-MWCNTs and MNTs in PVDF matrix were confirmed by field emission scanning electron microscopy. Electrical conductivity measurements were performed on these polymer composites using four probe technique. The addition of 2 wt.% of MNTs (2 wt.%, f-MWCNTs) to PVDF matrix results in an increase in the electrical conductivity from 10-16S/m to 4.5 × 10-5S/m (3.2 × 10-1S/m). Electromagnetic interference shielding effectiveness (EMI SE) was measured with vector network analyzer using waveguide sample holder in X-band frequency range. EMI SE of approximately 20 dB has been obtained with the addition of 5 wt.% MNTs-1 wt.% f-MWCNTs to PVDF in comparison with EMI SE of approximately 18 dB for 7 wt.% of f-MWCNTs indicating the potential use of the present MNT/f-MWCNT/PVDF composite as low-cost EMI shielding materials in X-band region. PMID:21711633

Search for Tensor, Vector, and Scalar Polarizations in the Stochastic Gravitational-Wave Background.

PubMed

Abbott, B P; Abbott, R; Abbott, T D; Acernese, F; Ackley, K; Adams, C; Adams, T; Addesso, P; Adhikari, R X; Adya, V B; Affeldt, C; Afrough, M; Agarwal, B; Agathos, M; Agatsuma, K; Aggarwal, N; Aguiar, O D; Aiello, L; Ain, A; Ajith, P; Allen, B; Allen, G; Allocca, A; Altin, P A; Amato, A; Ananyeva, A; Anderson, S B; Anderson, W G; Angelova, S V; Antier, S; Appert, S; Arai, K; Araya, M C; Areeda, J S; Arnaud, N; Ascenzi, S; Ashton, G; Ast, M; Aston, S M; Astone, P; Atallah, D V; Aufmuth, P; Aulbert, C; AultONeal, K; Austin, C; Avila-Alvarez, A; Babak, S; Bacon, P; Bader, M K M; Bae, S; Baker, P T; Baldaccini, F; Ballardin, G; Ballmer, S W; Banagiri, S; Barayoga, J C; Barclay, S E; Barish, B C; Barker, D; Barkett, K; Barone, F; Barr, B; Barsotti, L; Barsuglia, M; Barta, D; Bartlett, J; Bartos, I; Bassiri, R; Basti, A; Batch, J C; Bawaj, M; Bayley, J C; Bazzan, M; Bécsy, B; Beer, C; Bejger, M; Belahcene, I; Bell, A S; Berger, B K; Bergmann, G; Bero, J J; Berry, C P L; Bersanetti, D; Bertolini, A; Betzwieser, J; Bhagwat, S; Bhandare, R; Bilenko, I A; Billingsley, G; Billman, C R; Birch, J; Birney, R; Birnholtz, O; Biscans, S; Biscoveanu, S; Bisht, A; Bitossi, M; Biwer, C; Bizouard, M A; Blackburn, J K; Blackman, J; Blair, C D; Blair, D G; Blair, R M; Bloemen, S; Bock, O; Bode, N; Boer, M; Bogaert, G; Bohe, A; Bondu, F; Bonilla, E; Bonnand, R; Boom, B A; Bork, R; Boschi, V; Bose, S; Bossie, K; Bouffanais, Y; Bozzi, A; Bradaschia, C; Brady, P R; Branchesi, M; Brau, J E; Briant, T; Brillet, A; Brinkmann, M; Brisson, V; Brockill, P; Broida, J E; Brooks, A F; Brown, D A; Brown, D D; Brunett, S; Buchanan, C C; Buikema, A; Bulik, T; Bulten, H J; Buonanno, A; Buskulic, D; Buy, C; Byer, R L; Cabero, M; Cadonati, L; Cagnoli, G; Cahillane, C; Calderón Bustillo, J; Callister, T A; Calloni, E; Camp, J B; Canepa, M; Canizares, P; Cannon, K C; Cao, H; Cao, J; Capano, C D; Capocasa, E; Carbognani, F; Caride, S; Carney, M F; Diaz, J Casanueva; Casentini, C; Caudill, S; Cavaglià, M; Cavalier, F; Cavalieri, R; Cella, G; Cepeda, C B; Cerdá-Durán, P; Cerretani, G; Cesarini, E; Chamberlin, S J; Chan, M; Chao, S; Charlton, P; Chase, E; Chassande-Mottin, E; Chatterjee, D; Cheeseboro, B D; Chen, H Y; Chen, X; Chen, Y; Cheng, H-P; Chia, H; Chincarini, A; Chiummo, A; Chmiel, T; Cho, H S; Cho, M; Chow, J H; Christensen, N; Chu, Q; Chua, A J K; Chua, S; Chung, A K W; Chung, S; Ciani, G; Ciolfi, R; Cirelli, C E; Cirone, A; Clara, F; Clark, J A; Clearwater, P; Cleva, F; Cocchieri, C; Coccia, E; Cohadon, P-F; Cohen, D; Colla, A; Collette, C G; Cominsky, L R; Constancio, M; Conti, L; Cooper, S J; Corban, P; Corbitt, T R; Cordero-Carrión, I; Corley, K R; Cornish, N; Corsi, A; Cortese, S; Costa, C A; Coughlin, E; Coughlin, M W; Coughlin, S B; Coulon, J-P; Countryman, S T; Couvares, P; Covas, P B; Cowan, E E; Coward, D M; Cowart, M J; Coyne, D C; Coyne, R; Creighton, J D E; Creighton, T D; Cripe, J; Crowder, S G; Cullen, T J; Cumming, A; Cunningham, L; Cuoco, E; Canton, T Dal; Dálya, G; Danilishin, S L; D'Antonio, S; Danzmann, K; Dasgupta, A; Da Silva Costa, C F; Dattilo, V; Dave, I; Davier, M; Davis, D; Daw, E J; Day, B; De, S; DeBra, D; Degallaix, J; De Laurentis, M; Deléglise, S; Del Pozzo, W; Demos, N; Denker, T; Dent, T; De Pietri, R; Dergachev, V; De Rosa, R; DeRosa, R T; De Rossi, C; DeSalvo, R; de Varona, O; Devenson, J; Dhurandhar, S; Díaz, M C; Di Fiore, L; Di Giovanni, M; Di Girolamo, T; Di Lieto, A; Di Pace, S; Di Palma, I; Di Renzo, F; Doctor, Z; Dolique, V; Donovan, F; Dooley, K L; Doravari, S; Dorrington, I; Douglas, R; Dovale Álvarez, M; Downes, T P; Drago, M; Dreissigacker, C; Driggers, J C; Du, Z; Ducrot, M; Dupej, P; Dwyer, S E; Edo, T B; Edwards, M C; Effler, A; Eggenstein, H-B; Ehrens, P; Eichholz, J; Eikenberry, S S; Eisenstein, R A; Essick, R C; Estevez, D; Etienne, Z B; Etzel, T; Evans, M; Evans, T M; Factourovich, M; Fafone, V; Fair, H; Fairhurst, S; Fan, X; Farinon, S; Farr, B; Farr, W M; Fauchon-Jones, E J; Favata, M; Fays, M; Fee, C; Fehrmann, H; Feicht, J; Fejer, M M; Fernandez-Galiana, A; Ferrante, I; Ferreira, E C; Ferrini, F; Fidecaro, F; Finstad, D; Fiori, I; Fiorucci, D; Fishbach, M; Fisher, R P; Fitz-Axen, M; Flaminio, R; Fletcher, M; Fong, H; Font, J A; Forsyth, P W F; Forsyth, S S; Fournier, J-D; Frasca, S; Frasconi, F; Frei, Z; Freise, A; Frey, R; Frey, V; Fries, E M; Fritschel, P; Frolov, V V; Fulda, P; Fyffe, M; Gabbard, H; Gadre, B U; Gaebel, S M; Gair, J R; Gammaitoni, L; Ganija, M R; Gaonkar, S G; Garcia-Quiros, C; Garufi, F; Gateley, B; Gaudio, S; Gaur, G; Gayathri, V; Gehrels, N; Gemme, G; Genin, E; Gennai, A; George, D; George, J; Gergely, L; Germain, V; Ghonge, S; Ghosh, Abhirup; Ghosh, Archisman; Ghosh, S; Giaime, J A; Giardina, K D; Giazotto, A; Gill, K; Glover, L; Goetz, E; Goetz, R; Gomes, S; Goncharov, B; González, G; Gonzalez Castro, J M; Gopakumar, A; Gorodetsky, M L; Gossan, S E; Gosselin, M; Gouaty, R; Grado, A; Graef, C; Granata, M; Grant, A; Gras, S; Gray, C; Greco, G; Green, A C; Gretarsson, E M; Groot, P; Grote, H; Grunewald, S; Gruning, P; Guidi, G M; Guo, X; Gupta, A; Gupta, M K; Gushwa, K E; Gustafson, E K; Gustafson, R; Halim, O; Hall, B R; Hall, E D; Hamilton, E Z; Hammond, G; Haney, M; Hanke, M M; Hanks, J; Hanna, C; Hannam, M D; Hannuksela, O A; Hanson, J; Hardwick, T; Harms, J; Harry, G M; Harry, I W; Hart, M J; Haster, C-J; Haughian, K; Healy, J; Heidmann, A; Heintze, M C; Heitmann, H; Hello, P; Hemming, G; Hendry, M; Heng, I S; Hennig, J; Heptonstall, A W; Heurs, M; Hild, S; Hinderer, T; Hoak, D; Hofman, D; Holt, K; Holz, D E; Hopkins, P; Horst, C; Hough, J; Houston, E A; Howell, E J; Hreibi, A; Hu, Y M; Huerta, E A; Huet, D; Hughey, B; Husa, S; Huttner, S H; Huynh-Dinh, T; Indik, N; Inta, R; Intini, G; Isa, H N; Isac, J-M; Isi, M; Iyer, B R; Izumi, K; Jacqmin, T; Jani, K; Jaranowski, P; Jawahar, S; Jiménez-Forteza, F; Johnson, W W; Jones, D I; Jones, R; Jonker, R J G; Ju, L; Junker, J; Kalaghatgi, C V; Kalogera, V; Kamai, B; Kandhasamy, S; Kang, G; Kanner, J B; Kapadia, S J; Karki, S; Karvinen, K S; Kasprzack, M; Katolik, M; Katsavounidis, E; Katzman, W; Kaufer, S; Kawabe, K; Kéfélian, F; Keitel, D; Kemball, A J; Kennedy, R; Kent, C; Key, J S; Khalili, F Y; Khan, I; Khan, S; Khan, Z; Khazanov, E A; Kijbunchoo, N; Kim, Chunglee; Kim, J C; Kim, K; Kim, W; Kim, W S; Kim, Y-M; Kimbrell, S J; King, E J; King, P J; Kinley-Hanlon, M; Kirchhoff, R; Kissel, J S; Kleybolte, L; Klimenko, S; Knowles, T D; Koch, P; Koehlenbeck, S M; Koley, S; Kondrashov, V; Kontos, A; Korobko, M; Korth, W Z; Kowalska, I; Kozak, D B; Krämer, C; Kringel, V; Królak, A; Kuehn, G; Kumar, P; Kumar, R; Kumar, S; Kuo, L; Kutynia, A; Kwang, S; Lackey, B D; Lai, K H; Landry, M; Lang, R N; Lange, J; Lantz, B; Lanza, R K; Lartaux-Vollard, A; Lasky, P D; Laxen, M; Lazzarini, A; Lazzaro, C; Leaci, P; Leavey, S; Lee, C H; Lee, H K; Lee, H M; Lee, H W; Lee, K; Lehmann, J; Lenon, A; Leonardi, M; Leroy, N; Letendre, N; Levin, Y; Li, T G F; Linker, S D; Littenberg, T B; Liu, J; Lo, R K L; Lockerbie, N A; London, L T; Lord, J E; Lorenzini, M; Loriette, V; Lormand, M; Losurdo, G; Lough, J D; Lousto, C O; Lovelace, G; Lück, H; Lumaca, D; Lundgren, A P; Lynch, R; Ma, Y; Macas, R; Macfoy, S; Machenschalk, B; MacInnis, M; Macleod, D M; Magaña Hernandez, I; Magaña-Sandoval, F; Magaña Zertuche, L; Magee, R M; Majorana, E; Maksimovic, I; Man, N; Mandic, V; Mangano, V; Mansell, G L; Manske, M; Mantovani, M; Marchesoni, F; Marion, F; Márka, S; Márka, Z; Markakis, C; Markosyan, A S; Markowitz, A; Maros, E; Marquina, A; Martelli, F; Martellini, L; Martin, I W; Martin, R M; Martynov, D V; Mason, K; Massera, E; Masserot, A; Massinger, T J; Masso-Reid, M; Mastrogiovanni, S; Matas, A; Matichard, F; Matone, L; Mavalvala, N; Mazumder, N; McCarthy, R; McClelland, D E; McCormick, S; McCuller, L; McGuire, S C; McIntyre, G; McIver, J; McManus, D J; McNeill, L; McRae, T; McWilliams, S T; Meacher, D; Meadors, G D; Mehmet, M; Meidam, J; Mejuto-Villa, E; Melatos, A; Mendell, G; Mercer, R A; Merilh, E L; Merzougui, M; Meshkov, S; Messenger, C; Messick, C; Metzdorff, R; Meyers, P M; Miao, H; Michel, C; Middleton, H; Mikhailov, E E; Milano, L; Miller, A L; Miller, B B; Miller, J; Millhouse, M; Milovich-Goff, M C; Minazzoli, O; Minenkov, Y; Ming, J; Mishra, C; Mitra, S; Mitrofanov, V P; Mitselmakher, G; Mittleman, R; Moffa, D; Moggi, A; Mogushi, K; Mohan, M; Mohapatra, S R P; Montani, M; Moore, C J; Moraru, D; Moreno, G; Morriss, S R; Mours, B; Mow-Lowry, C M; Mueller, G; Muir, A W; Mukherjee, Arunava; Mukherjee, D; Mukherjee, S; Mukund, N; Mullavey, A; Munch, J; Muñiz, E A; Muratore, M; Murray, P G; Napier, K; Nardecchia, I; Naticchioni, L; Nayak, R K; Neilson, J; Nelemans, G; Nelson, T J N; Nery, M; Neunzert, A; Nevin, L; Newport, J M; Newton, G; Ng, K K Y; Nguyen, T T; Nichols, D; Nielsen, A B; Nissanke, S; Nitz, A; Noack, A; Nocera, F; Nolting, D; North, C; Nuttall, L K; Oberling, J; O'Dea, G D; Ogin, G H; Oh, J J; Oh, S H; Ohme, F; Okada, M A; Oliver, M; Oppermann, P; Oram, Richard J; O'Reilly, B; Ormiston, R; Ortega, L F; O'Shaughnessy, R; Ossokine, S; Ottaway, D J; Overmier, H; Owen, B J; Pace, A E; Page, J; Page, M A; Pai, A; Pai, S A; Palamos, J R; Palashov, O; Palomba, C; Pal-Singh, A; Pan, Howard; Pan, Huang-Wei; Pang, B; Pang, P T H; Pankow, C; Pannarale, F; Pant, B C; Paoletti, F; Paoli, A; Papa, M A; Parida, A; Parker, W; Pascucci, D; Pasqualetti, A; Passaquieti, R; Passuello, D; Patil, M; Patricelli, B; Pearlstone, B L; Pedraza, M; Pedurand, R; Pekowsky, L; Pele, A; Penn, S; Perez, C J; Perreca, A; Perri, L M; Pfeiffer, H P; Phelps, M; Piccinni, O J; Pichot, M; Piergiovanni, F; Pierro, V; Pillant, G; Pinard, L; Pinto, I M; Pirello, M; Pitkin, M; Poe, M; Poggiani, R; Popolizio, P; Porter, E K; Post, A; Powell, J; Prasad, J; Pratt, J W W; Pratten, G; Predoi, V; Prestegard, T; Prijatelj, M; Principe, M; Privitera, S; Prodi, G A; Prokhorov, L G; Puncken, O; Punturo, M; Puppo, P; Pürrer, M; Qi, H; Quetschke, V; Quintero, E A; Quitzow-James, R; Raab, F J; Rabeling, D S; Radkins, H; Raffai, P; Raja, S; Rajan, C; Rajbhandari, B; Rakhmanov, M; Ramirez, K E; Ramos-Buades, A; Rapagnani, P; Raymond, V; Razzano, M; Read, J; Regimbau, T; Rei, L; Reid, S; Reitze, D H; Ren, W; Reyes, S D; Ricci, F; Ricker, P M; Rieger, S; Riles, K; Rizzo, M; Robertson, N A; Robie, R; Robinet, F; Rocchi, A; Rolland, L; Rollins, J G; Roma, V J; Romano, J D; Romano, R; Romel, C L; Romie, J H; Rosińska, D; Ross, M P; Rowan, S; Rüdiger, A; Ruggi, P; Rutins, G; Ryan, K; Sachdev, S; Sadecki, T; Sadeghian, L; Sakellariadou, M; Salconi, L; Saleem, M; Salemi, F; Samajdar, A; Sammut, L; Sampson, L M; Sanchez, E J; Sanchez, L E; Sanchis-Gual, N; Sandberg, V; Sanders, J R; Sassolas, B; Saulson, P R; Sauter, O; Savage, R L; Sawadsky, A; Schale, P; Scheel, M; Scheuer, J; Schmidt, J; Schmidt, P; Schnabel, R; Schofield, R M S; Schönbeck, A; Schreiber, E; Schuette, D; Schulte, B W; Schutz, B F; Schwalbe, S G; Scott, J; Scott, S M; Seidel, E; Sellers, D; Sengupta, A S; Sentenac, D; Sequino, V; Sergeev, A; Shaddock, D A; Shaffer, T J; Shah, A A; Shahriar, M S; Shaner, M B; Shao, L; Shapiro, B; Shawhan, P; Sheperd, A; Shoemaker, D H; Shoemaker, D M; Siellez, K; Siemens, X; Sieniawska, M; Sigg, D; Silva, A D; Singer, L P; Singh, A; Singhal, A; Sintes, A M; Slagmolen, B J J; Smith, B; Smith, J R; Smith, R J E; Somala, S; Son, E J; Sonnenberg, J A; Sorazu, B; Sorrentino, F; Souradeep, T; Spencer, A P; Srivastava, A K; Staats, K; Staley, A; Steinke, M; Steinlechner, J; Steinlechner, S; Steinmeyer, D; Stevenson, S P; Stone, R; Stops, D J; Strain, K A; Stratta, G; Strigin, S E; Strunk, A; Sturani, R; Stuver, A L; Summerscales, T Z; Sun, L; Sunil, S; Suresh, J; Sutton, P J; Swinkels, B L; Szczepańczyk, M J; Tacca, M; Tait, S C; Talbot, C; Talukder, D; Tanner, D B; Tao, D; Tápai, M; Taracchini, A; Tasson, J D; Taylor, J A; Taylor, R; Tewari, S V; Theeg, T; Thies, F; Thomas, E G; Thomas, M; Thomas, P; Thorne, K A; Thrane, E; Tiwari, S; Tiwari, V; Tokmakov, K V; Toland, K; Tonelli, M; Tornasi, Z; Torres-Forné, A; Torrie, C I; Töyrä, D; Travasso, F; Traylor, G; Trinastic, J; Tringali, M C; Trozzo, L; Tsang, K W; Tse, M; Tso, R; Tsukada, L; Tsuna, D; Tuyenbayev, D; Ueno, K; Ugolini, D; Unnikrishnan, C S; Urban, A L; Usman, S A; Vahlbruch, H; Vajente, G; Valdes, G; van Bakel, N; van Beuzekom, M; van den Brand, J F J; Van Den Broeck, C; Vander-Hyde, D C; van der Schaaf, L; van Heijningen, J V; van Veggel, A A; Vardaro, M; Varma, V; Vass, S; Vasúth, M; Vecchio, A; Vedovato, G; Veitch, J; Veitch, P J; Venkateswara, K; Venugopalan, G; Verkindt, D; Vetrano, F; Viceré, A; Viets, A D; Vinciguerra, S; Vine, D J; Vinet, J-Y; Vitale, S; Vo, T; Vocca, H; Vorvick, C; Vyatchanin, S P; Wade, A R; Wade, L E; Wade, M; Walet, R; Walker, M; Wallace, L; Walsh, S; Wang, G; Wang, H; Wang, J Z; Wang, W H; Wang, Y F; Ward, R L; Warner, J; Was, M; Watchi, J; Weaver, B; Wei, L-W; Weinert, M; Weinstein, A J; Weiss, R; Wen, L; Wessel, E K; Weßels, P; Westerweck, J; Westphal, T; Wette, K; Whelan, J T; Whiting, B F; Whittle, C; Wilken, D; Williams, D; Williams, R D; Williamson, A R; Willis, J L; Willke, B; Wimmer, M H; Winkler, W; Wipf, C C; Wittel, H; Woan, G; Woehler, J; Wofford, J; Wong, K W K; Worden, J; Wright, J L; Wu, D S; Wysocki, D M; Xiao, S; Yamamoto, H; Yancey, C C; Yang, L; Yap, M J; Yazback, M; Yu, Hang; Yu, Haocun; Yvert, M; Zadrożny, A; Zanolin, M; Zelenova, T; Zendri, J-P; Zevin, M; Zhang, L; Zhang, M; Zhang, T; Zhang, Y-H; Zhao, C; Zhou, M; Zhou, Z; Zhu, S J; Zhu, X J; Zucker, M E; Zweizig, J

2018-05-18

The detection of gravitational waves with Advanced LIGO and Advanced Virgo has enabled novel tests of general relativity, including direct study of the polarization of gravitational waves. While general relativity allows for only two tensor gravitational-wave polarizations, general metric theories can additionally predict two vector and two scalar polarizations. The polarization of gravitational waves is encoded in the spectral shape of the stochastic gravitational-wave background, formed by the superposition of cosmological and individually unresolved astrophysical sources. Using data recorded by Advanced LIGO during its first observing run, we search for a stochastic background of generically polarized gravitational waves. We find no evidence for a background of any polarization, and place the first direct bounds on the contributions of vector and scalar polarizations to the stochastic background. Under log-uniform priors for the energy in each polarization, we limit the energy densities of tensor, vector, and scalar modes at 95% credibility to Ω_{0}^{T}<5.58×10^{-8}, Ω_{0}^{V}<6.35×10^{-8}, and Ω_{0}^{S}<1.08×10^{-7} at a reference frequency f_{0}=25  Hz.

Estimation of chaotic coupled map lattices using symbolic vector dynamics

NASA Astrophysics Data System (ADS)

Wang, Kai; Pei, Wenjiang; Cheung, Yiu-ming; Shen, Yi; He, Zhenya

2010-01-01

In [K. Wang, W.J. Pei, Z.Y. He, Y.M. Cheung, Phys. Lett. A 367 (2007) 316], an original symbolic vector dynamics based method has been proposed for initial condition estimation in additive white Gaussian noisy environment. The estimation precision of this estimation method is determined by symbolic errors of the symbolic vector sequence gotten by symbolizing the received signal. This Letter further develops the symbolic vector dynamical estimation method. We correct symbolic errors with backward vector and the estimated values by using different symbols, and thus the estimation precision can be improved. Both theoretical and experimental results show that this algorithm enables us to recover initial condition of coupled map lattice exactly in both noisy and noise free cases. Therefore, we provide novel analytical techniques for understanding turbulences in coupled map lattice.

Coupled channel analysis of overlinepp annihilation into π0π0π0, π0ηη and π0π0η

NASA Astrophysics Data System (ADS)

Amsler, C.; Armstrong, D. S.; Baker, C. A.; Barnett, B. M.; Batty, C. J.; Benayoun, M.; Beuchert, K.; Birien, P.; Blüm, P.; Bossingham, R.; Braune, K.; Brose, J.; Bugg, D. V.; Case, T.; Chung, S. U.; Cooper, A. R.; Cramer, O.; Crowe, K. M.; Degener, T.; Dietz, H. P.; Djaoshvili, N.; Dombroski, S. v.; Doser, M.; Dünnweber, W.; Engelhardt, D.; Englert, M.; Faessler, M. A.; Felix, C.; Giarritta, P.; Hackmann, R.; Haddock, R. P.; Heinsius, F. H.; Herz, M.; Hessey, N. P.; Hidas, P.; Holzhaussen, C.; Illinger, P.; Jamnik, D.; Kalinowsky, H.; Kalteyer, B.; Kämmle, B.; Kiel, T.; Kisiel, J.; Klempt, E.; Koch, H.; Kobel, M.; Kolo, C.; Kunze, M.; Lakata, M.; Landua, R.; Lüdemann, J.; Matthäy, H.; McCrady, R.; Merlo, J. P.; Meyer, C. A.; Montanet, L.; Noble, A.; Ouared, R.; Ould-Saada, F.; Peters, K.; Pinder, C. N.; Pinter, G.; Ravndal, S.; Regenfus, C.; Schäfer, E.; Schmidt, P.; Schütrumpf, M.; Seibert, R.; Spanier, S.; Stöck, H.; Straßburger, C.; Strohbusch, U.; Suffert, M.; Thoma, U.; Tischhäuser, M.; Urner, D.; Völcker, C.; Walter, F.; Walther, D.; Wiedner, U.; Winter, N.; Zoll, J.; Zou, B. S.; Zupančič, Č.; Crystal Barrel Collaboration

1995-02-01

We confirm the existence of the two IG( JPC) = 0 +(0 ++) resonances f0(1370) and f0(1500) reported by us in earlier analyses. The analysis presented here couples the final states π0π0π0, π0π0η and π0ηη of overlinepp annihilation at rest. It is based on a 3 × 3 K-matrix. We find masses and widths of M = (1390±30) MeV, Γ = (380±80) MeV; and M = (1500±10) MeV, Γ = (154 ± 30) MeV, respectively. The product branching ratios for the production and decay into π0π0 and ηη of the f 0(1500) are (1.27 ± 0.33) · 10 -3 and (0.60 ± 0.17) · 10 -3, respectively.

Attenuated Human Parainfluenza Virus Type 1 (HPIV1) Expressing the Fusion Glycoprotein of Human Respiratory Syncytial Virus (RSV) as a Bivalent HPIV1/RSV Vaccine

PubMed Central

Mackow, Natalie; Amaro-Carambot, Emérito; Liang, Bo; Surman, Sonja; Lingemann, Matthias; Yang, Lijuan; Collins, Peter L.

2015-01-01

ABSTRACT Live attenuated recombinant human parainfluenza virus type 1 (rHPIV1) was investigated as a vector to express the respiratory syncytial virus (RSV) fusion (F) glycoprotein, to provide a bivalent vaccine against RSV and HPIV1. The RSV F gene was engineered to include HPIV1 transcription signals and inserted individually into three gene locations in each of the two attenuated rHPIV1 backbones. Each backbone contained a single previously described attenuating mutation that was stabilized against deattenuation, specifically, a non-temperature-sensitive deletion mutation involving 6 nucleotides in the overlapping P/C open reading frames (ORFs) (CΔ170) or a temperature-sensitive missense mutation in the L ORF (LY942A). The insertion sites in the genome were pre-N (F1), N-P (F2), or P-M (F3) and were identical for both backbones. In vitro, the presence of the F insert reduced the rate of virus replication, but the final titers were the same as the final titer of wild-type (wt) HPIV1. High levels of RSV F expression in cultured cells were observed with rHPIV1-CΔ170-F1, -F2, and -F3 and rHPIV1-LY942A-F1. In hamsters, the rHPIV1-CΔ170-F1, -F2, and -F3 vectors were moderately restricted in the nasal turbinates, highly restricted in lungs, and genetically stable in vivo. Among the CΔ170 vectors, the F1 virus was the most immunogenic and protective against wt RSV challenge. The rHPIV1-LY942A vectors were highly restricted in vivo and were not detectably immunogenic or protective, indicative of overattenuation. The CΔ170-F1 construct appears to be suitably attenuated and immunogenic for further development as a bivalent intranasal pediatric vaccine. IMPORTANCE There are no vaccines for the pediatric respiratory pathogens RSV and HPIV. We are developing live attenuated RSV and HPIV vaccines for use in virus-naive infants. Live attenuated RSV strains in particular are difficult to develop due to their poor growth and physical instability, but these obstacles could be avoided by the use of a vaccine vector. We describe the development and preclinical evaluation of live attenuated rHPIV1 vectors expressing the RSV F protein. Two different attenuated rHPIV1 backbones were each engineered to express RSV F from three different gene positions. The rHPIV1-CΔ170-F1 vector, bearing an attenuating deletion mutation (CΔ170) in the P/C gene and expressing RSV F from the pre-N position, was attenuated, stable, and immunogenic against the RSV F protein and HPIV1 in the hamster model and provided substantial protection against RSV challenge. This study provides a candidate rHPIV1-RSV-F vaccine virus suitable for continued development as a bivalent vaccine against two major childhood pathogens. PMID:26223633

A FRET-Based Method for Probing the Conformational Behavior of an Intrinsically Disordered Repeat Domain from Bordetella pertussis Adenylate Cyclase

DTIC Science & Technology

2009-10-22

ELEMENT NUMBER 6. AUTHOR( S ) 5d. PROJECT NUMBER 5e. TASK NUMBER 5f. WORK UNIT NUMBER 7. PERFORMING ORGANIZATION NAME( S ) AND ADDRESS(ES...MONITORING AGENCY NAME( S ) AND ADDRESS(ES) 10. SPONSOR/MONITOR’S ACRONYM( S ) 11. SPONSOR/MONITOR’S REPORT NUMBER( S ) 12. DISTRIBUTION/AVAILABILITY STATEMENT...fusion protein C*-BR( S )-Y* expression vector pET/C*-CyaA1488-1680-Y*, nonfluorescent CFP expression vector pET/CFP*, and the maltose binding protein-RTX

New approach to the resummation of logarithms in Higgs-boson decays to a vector quarkonium plus a photon

NASA Astrophysics Data System (ADS)

Bodwin, Geoffrey T.; Chung, Hee Sok; Ee, June-Haak; Lee, Jungil

2017-03-01

We present a calculation of the rates for Higgs-boson decays to a vector heavy-quarkonium state plus a photon, where the heavy-quarkonium states are the J /ψ and the ϒ (n S ) states, with n =1 , 2, or 3. The calculation is carried out in the light-cone formalism, combined with nonrelativistic QCD factorization, and is accurate at leading order in mQ2/mH2, where mQ is the heavy-quark mass and mH is the Higgs-boson mass. The calculation contains corrections through next-to-leading order in the strong-coupling constant αs and the square of the heavy-quark velocity v , and includes a resummation of logarithms of mH2/mQ2 at next-to-leading logarithmic accuracy. We have developed a new method, which makes use of Abel summation, accelerated through the use of Padé approximants, to deal with divergences in the resummed expressions for the quarkonium light-cone distribution amplitudes. This approach allows us to make definitive calculations of the resummation effects. Contributions from the order-αs and order-v2 corrections to the light-cone distribution amplitudes that we obtain with this new method differ substantially from the corresponding contributions that one obtains from a model light-cone distribution amplitude [M. König and M. Neubert, J. High Energy Phys. 08 (2015) 012, 10.1007/JHEP08(2015)012]. Our results for the real parts of the direct-process amplitudes are considerably smaller than those from one earlier calculation [G. T. Bodwin, H. S. Chung, J.-H. Ee, J. Lee, and F. Petriello, Phys. Rev. D 90, 113010 (2014), 10.1103/PhysRevD.90.113010], reducing the sensitivity to the Higgs-boson-heavy-quark couplings, and are somewhat smaller than those from another earlier calculation [M. König and M. Neubert, J. High Energy Phys. 08 (2015) 012, 10.1007/JHEP08(2015)012]. However, our results for the standard-model Higgs-boson branching fractions are in good agreement with those in M. König and M. Neubert, J. High Energy Phys. 08 (2015) 012, 10.1007/JHEP08(2015)012.

Is there a sign of new physics in beryllium transitions?

NASA Astrophysics Data System (ADS)

Fornal, Bartosz

2017-01-01

A 6.8 σ anomaly in the invariant mass distribution of e+e- pairs produced via internal pair creation in 8 Be nuclear transitions has been reported recently by Krasznahorkay et al. in Phys. Rev. Lett. 116 (2016) 042501. The data can be explained by a 17 MeV vector gauge boson X produced in the transition of an excited beryllium state to the ground state, 8Be* ->8 Be X , followed by the decay X ->e+e- . We find that the gauge boson X can be associated with a new ``protophobic'' fifth force (i.e.with a coupling to protons suppressed compared to its coupling to neutrons) with a characteristic range of 10 fm and milli-charged couplings to first generation quarks and electrons. We show that such a ``protophobic'' gauge boson is consistent with all available experimental constraints and we discuss several ways to embed this new particle into an anomaly-free extension of the Standard Model. One of the most appealing theories of this type is a model with gauged baryon number, in which the new gauge boson kinetically mixes with the photon, and provides a portal to the dark matter sector. Apart from the phenomenological richness of the model, it can also alleviate the current 3.6 σ discrepancy between the predicted and measured values of the muon's anomalous magnetic moment. B.F. acknowledges partial support from DOE Grant DE-SC0009919 and NSF Grant PHY-1316792.

Three-wave and four-wave interactions in gravity wave turbulence

NASA Astrophysics Data System (ADS)

Aubourg, Quentin; Campagne, Antoine; Peureux, Charles; Ardhuin, Fabrice; Sommeria, Joel; Viboud, Samuel; Mordant, Nicolas

2017-11-01

Weak-turbulence theory is a statistical framework to describe a large ensemble of nonlinearly interacting waves. The archetypal example of such system is the ocean surface that is made of interacting surface gravity waves. Here we describe a laboratory experiment dedicated to probe the statistical properties of turbulent gravity waves. We set up an isotropic state of interacting gravity waves in the Coriolis facility (13-m-diam circular wave tank) by exciting waves at 1 Hz by wedge wave makers. We implement a stereoscopic technique to obtain a measurement of the surface elevation that is resolved in both space and time. Fourier analysis shows that the laboratory spectra are systematically steeper than the theoretical predictions and the field observations in the Black Sea by Leckler et al. [F. Leckler et al., J. Phys. Oceanogr. 45, 2484 (2015), 10.1175/JPO-D-14-0237.1]. We identify a strong impact of surface dissipation on the scaling of the Fourier spectrum at the scales that are accessible in the experiments. We use bicoherence and tricoherence statistical tools in frequency and/or wave-vector space to identify the active nonlinear coupling. These analyses are also performed on the field data by Leckler et al. for comparison with the laboratory data. Three-wave coupling is characterized by and shown to involve mostly quasiresonances of waves with second- or higher-order harmonics. Four-wave coupling is not observed in the laboratory but is evidenced in the field data. We discuss temporal scale separation to explain our observations.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Chizhov, M. V., E-mail: mih@phys.uni-sofia.bg; Bednyakov, V. A., E-mail: bedny@jinr.ru

The gauge coupling unification can be achieved at a unification scale around 5×10{sup 13} GeV if the Standard Model scalar sector is extended with extra Higgs-like doublets. The relevant new scalar degrees of freedom in the form of chiral Z* and W* vector bosons might “be visible” already at about 700 GeV. Their eventual preferred coupling to the heavy quarks explains the non observation of these bosons in the first LHC run and provides promising expectation for the second LHC run.

Single residue AAV capsid mutation improves transduction of photoreceptors in the Abca4-/- mouse and bipolar cells in the rd1 mouse and human retina ex vivo.

PubMed

De Silva, Samantha R; Charbel Issa, Peter; Singh, Mandeep S; Lipinski, Daniel M; Barnea-Cramer, Alona O; Walker, Nathan J; Barnard, Alun R; Hankins, Mark W; MacLaren, Robert E

2016-11-01

Gene therapy using adeno-associated viral (AAV) vectors for the treatment of retinal degenerations has shown safety and efficacy in clinical trials. However, very high levels of vector expression may be necessary for the treatment of conditions such as Stargardt disease where a dual vector approach is potentially needed, or in optogenetic strategies for end-stage degeneration in order to achieve maximal light sensitivity. In this study, we assessed two vectors with single capsid mutations, rAAV2/2(Y444F) and rAAV2/8(Y733F) in their ability to transduce retina in the Abca4 -/- and rd1 mouse models of retinal degeneration. We noted significantly increased photoreceptor transduction using rAAV2/8(Y733F) in the Abca4 -/- mouse, in contrast to previous work where vectors tested in this model have shown low levels of photoreceptor transduction. Bipolar cell transduction was achieved following subretinal delivery of both vectors in the rd1 mouse, and via intravitreal delivery of rAAV2/2(Y444F). The successful use of rAAV2/8(Y733F) to target bipolar cells was further validated on human tissue using an ex vivo culture system of retinal explants. Capsid mutant AAV vectors transduce human retinal cells and may be particularly suited to treat retinal degenerations in which high levels of transgene expression are required.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Moyotl, A.; Rosado, A.; Tavares-Velasco, G.

The magnetic dipole moment and the electric dipole moment of leptons are calculated under the assumption of lepton flavor violation (LFV) induced by spin-1 unparticles with both vector and axial-vector couplings to leptons, including a CP-violating phase. The experimental limits on the muon magnetic dipole moment and LFV process, such as the decay l{sub i}{sup -}{yields}l{sub j}{sup -}l{sub k}{sup -}l{sub k}{sup +}, are then used to constrain the LFV couplings for particular values of the unparticle operator dimension d{sub U} and the unparticle scale {Lambda}{sub U}, assuming that LFV transitions between the tau and muon leptons are dominant. It ismore » found that the current experimental constraints favor a scenario with dominance of the vector couplings over the axial-vector couplings. We also obtain estimates for the electric dipole moments of the electron and the muon, which are well below the experimental values.« less

Vector mesons in the Nambu-Jona-Lasinio model

NASA Astrophysics Data System (ADS)

Schüren, C.; Döring, F.; Ruiz Arriola, E.; Goeke, K.

1993-12-01

We investigate solitonic solutions with baryon number equal to one of the semi-bosonized SU(2) Nambu-Jona-Lasinio model including σ -, π -, ρ -, A 1- and ω-mesons both on the chiral circle ( σ2r) + π2( r) = f2π) and beyond it ( σ2( r) + π2( r) ≠ f2π). The action is treated in the mesonic and baryonic sector in the leading order of the large- Nc expansion (one-quark-loop approximation). The UV-divergent real part of the effective action is rendered finite using different gauge-invariant regularization methods (Pauli-Villars and proper time). The parameters of the model are fixed in two different ways: either approximately by a heat kernel expansion of the effective action up to second order or by an exact calculation of the mesonic on-shell masses. This leaves the constituent quark mass as the only free parameter of the model. In the solitonic sector we pay special attention to the way the Wick rotation from euclidean space back to Minkowski space has to be performed. We get solitonic solutions from hedgehoglike field configurations on the chiral circle for a wide range of couplings. We also find that if the chiral-circle constraint is relaxed vector mesons provide stable solitonic solutions. Moreover, whether the baryon number is carried by the valence quarks or by the Dirac sea depends strongly on the particular values of the constituent quark mass. We also study the low-energy limit of the model and its connection to chiral perturbation theory. To this end a covariant-derivative expansion is performed in the presence of external fields. After integrating out the scalar, vector and axial degrees of freedom this leads to the corresponding low-energy parameters as e.g. pion radii and some threshold parameters for pion-pion scattering. Vector mesons provide a natural explanation for an axial coupling constant at the quark level gAQ lower than one. However, we find for the gAN of the nucleon noticeable deviations from the non-relativistic quark model prediction g AN = {5}/{3}g AQ. For the values of the parameters where solitons are found, pionic radii come out to be too small. Finally, the relation of the present model to other chiral soliton models as well as some effective lagrangians is displayed.

[Comparison of immunosuppressive effects between human placental MSCs derived from fetal and maternal origins on the rejection of allogenic skin grafts in mice].

PubMed

Hao, Guiliang; Wang, Libin; Chen, Dongmei; Liang, Xueyun; Wang, Qiong; Zhu, Yongzhao; Ma, Xiaona; Liu, Xiaoming; Li, Yukui

2015-05-01

To compare the immunosuppressive effects of maternal and fetal placental mesenchymal stem cells (mPMSCs and fPMSCs, respectively) on the rejection of allogenic skin transplants in mice, and further to investigate the mechanism underlying this suppression. The mPMSCs and fPMSCs were isolated from human term placentas. The expressions of cell surface markers were detected by flow cytometry. Cell proliferation capacity was characterized by MTT colorimetric assay. CD200 protein expressed on fPMSCs was neutralized with streaming monoclonal antibodies, and mPMSCs were infected with adenovirus expression vector carrying CD200 cDNA. For skin transplantation, 60 C57BL/6 mice were randomly divided into 6 groups as skin transplant recipients, and ICR mice served as skin donors. After establishment of the allogenic skin transplants, recipient mice of the 6 groups were intravenous injected respectively with PBS, mPMSCs, fPMSCs, fPMSCs combined with anti-CD200 antibodies, mPMSCs with CD200 expressing vectors, and mPMSCs with empty vectors. The conditions and survival time of the skin grafts were inspected daily, and the expressions of interleukin 17 (IL-17), interferon γ (IFN-γ), tumor necrosis factor α (TNF-α) and interleukin 12 (IL-12) in blood and spleen were measured at the end of the study by ELISA and reverse transcription PCR. The majority (>70%) of fPMSCs were detected CD200 positive, while only a minor fraction (about 2%) of CD-200 positive cells were seen in mPMSCs. In the allogenic skin graft mice, the graft survival time in both mPMSCs- and fPMSCs-treated groups were significantly longer than that in PBS group [(5.6±1.17) days], while the fPMSCs group [(10.6±1.43) days] was more dominant than mPMSCs group [(7.7±1.42) days]. Neutralizing anti-CD200 antibody reduced the graft survival [(8.2±1.14) days] of the fPMSCs group to the level of that in mPMSCs group, while enforced expression of CD200 increased the graft survival [(10.7±1.34) days] of the mPMSCs group to the level of the fPMSCs group. The empty vector-transfected mPMSCs showed a similar effect on graft survival [(7.8±1.32) days] as that in mPMSCs group, longer than PBS group but shorter than fPMSCs and mPMSCs combined with CD200 groups. Comparing with PBS group, the expressions of IL-17, IFN-γ and TNF-α were significantly reduced in mPMSCs and fPMSCs groups. The reduction of these cytokine expressions in the fPMSCs group was neutralized when anti-CD200 antibody was applied, while this reduction in the mPMSCs-treated mice was further enhanced when the mPMSCs were enforced to express CD200. The immunosuppressive effect of fPMSCs on the rejection of allogenic skin transplantation was higher than that of mPMSCs, and this difference was partially contributed by CD200 signaling pathway. The mechanism of this suppression may mediate the inhibition of IL-17, IFN-γ, TNF-α and IL-12 expressions. The fPMSCs may be a suitable choice for immunosuppression on skin transplantation.

Angular dependence of primordial trispectra and CMB spectral distortions

DOE Office of Scientific and Technical Information (OSTI.GOV)

Shiraishi, Maresuke; Bartolo, Nicola; Liguori, Michele, E-mail: maresuke.shiraishi@ipmu.jp, E-mail: nicola.bartolo@pd.infn.it, E-mail: michele.liguori@pd.infn.it

2016-10-01

Under the presence of anisotropic sources in the inflationary era, the trispectrum of the primordial curvature perturbation has a very specific angular dependence between each wavevector that is distinguishable from the one encountered when only scalar fields are present, characterized by an angular dependence described by Legendre polynomials. We examine the imprints left by curvature trispectra on the TT μ bispectrum, generated by the correlation between temperature anisotropies (T) and chemical potential spectral distortions (μ) of the Cosmic Microwave Background (CMB). Due to the angular dependence of the primordial signal, the corresponding TT μ bispectrum strongly differs in shape frommore » TT μ sourced by the usual g {sub NL} or τ{sub NL} local trispectra, enabling us to obtain an unbiased estimation. From a Fisher matrix analysis, we find that, in a cosmic-variance-limited (CVL) survey of TT μ, a minimum detectable value of the quadrupolar Legendre coefficient is d {sub 2} ∼ 0.01, which is 4 orders of magnitude better than the best value attainable from the TTTT CMB trispectrum. In the case of an anisotropic inflationary model with a f (φ) F {sup 2} interaction (coupling the inflaton field φ with a vector kinetic term F {sup 2}), the size of the curvature trispectrum is related to that of quadrupolar power spectrum asymmetry, g {sub *}. In this case, a CVL measurement of TT μ makes it possible to measure g {sub *} down to 10{sup −3}.« less

General covariant Horava-Lifshitz gravity without projectability condition and its applications to cosmology

NASA Astrophysics Data System (ADS)

Zhu, Tao; Shu, Fu-Wen; Wu, Qiang; Wang, Anzhong

2012-02-01

We consider an extended theory of Horava-Lifshitz gravity with the detailed balance condition softly breaking, but without the projectability condition. With the former, the number of independent coupling constants is significantly reduced. With the latter and by extending the original foliation-preserving diffeomorphism symmetry Diff(M,F) to include a local U(1) symmetry, the spin-0 gravitons are eliminated. Thus, all the problems related to them disappear, including the instability, strong coupling, and different speeds in the gravitational sector. When the theory couples to a scalar field, we find that the scalar field is not only stable in both the ultraviolet and infrared, but also free of the strong coupling problem, because of the presence of high-order spatial derivative terms of the scalar field. Furthermore, applying the theory to cosmology, we find that due to the additional U(1) symmetry, the Friedmann-Robertson-Walker (FRW) universe is necessarily flat. We also investigate the scalar, vector, and tensor perturbations of the flat FRW universe, and derive the general linearized field equations for each kind of the perturbations.

Chimeric Bovine/Human Parainfluenza Virus Type 3 Expressing Respiratory Syncytial Virus (RSV) F Glycoprotein: Effect of Insert Position on Expression, Replication, Immunogenicity, Stability, and Protection against RSV Infection

PubMed Central

Munir, Shirin; Amaro-Carambot, Emerito; Surman, Sonja; Mackow, Natalie; Yang, Lijuan; Buchholz, Ursula J.; Collins, Peter L.; Schaap-Nutt, Anne

2014-01-01

ABSTRACT A recombinant chimeric bovine/human parainfluenza type 3 virus (rB/HPIV3) vector expressing the respiratory syncytial virus (RSV) fusion F glycoprotein previously exhibited disappointing levels of RSV F immunogenicity and genetic stability in children (D. Bernstein et al., Pediatr. Infect. Dis. J. 31:109–114, 2012; C.-F. Yang et al., Vaccine 31:2822–2827, 2013). To investigate parameters that might affect vaccine performance and stability, we constructed and characterized rB/HPIV3 viruses expressing RSV F from the first (pre-N), second (N-P), third (P-M), and sixth (HN-L) genome positions. There was a 30- to 69-fold gradient in RSV F expression from the first to the sixth position. The inserts moderately attenuated vector replication in vitro and in the upper and lower respiratory tracts of hamsters: this was not influenced by the level of RSV F expression and syncytium formation. Surprisingly, inserts in the second, third, and sixth positions conferred increased temperature sensitivity: this was greatest for the third position and was the most attenuating in vivo. Each rB/HPIV3 vector induced a high titer of neutralizing antibodies in hamsters against RSV and HPIV3. Protection against RSV challenge was greater for position 2 than for position 6. Evaluation of insert stability suggested that RSV F is under selective pressure to be silenced during vector replication in vivo, but this was not exacerbated by a high level of RSV F expression and generally involved a small percentage of recovered vector. Vector passaged in vitro accumulated mutations in the HN open reading frame, causing a dramatic increase in plaque size that may have implications for vaccine production and immunogenicity. IMPORTANCE The research findings presented here will be instrumental for improving the design of a bivalent pediatric vaccine for respiratory syncytial virus and parainfluenza virus type 3, two major causes of severe respiratory tract infection in infants and young children. Moreover, this knowledge has general application to the development and clinical evaluation of other mononegavirus vectors and vaccines. PMID:24478424

Protection against California 2002 NDV strain afforded by adenovirus vectored vaccine expressing Fusion or Hemagglutination-neuraminidase genes

USDA-ARS?s Scientific Manuscript database

Vectored vaccines expressing the combination of the hemagglutinin-neuraminidase (HN) and fusion (F) genes generally have better clinical protection against Newcastle disease virus (NDV) than when either the F and HN genes are expressed alone. Interestingly, the protection induced by F is usually bet...

Entanglement dynamics and position-momentum entropic uncertainty relation of a Λ-type three-level atom interacting with a two-mode cavity field in the presence of nonlinearities

NASA Astrophysics Data System (ADS)

Faghihi, M. J.; Tavassoly, M. K.; Hooshmandasl, M. R.

2013-05-01

In this paper, the interaction between a $\\Lambda$-type three-level atom and two-mode cavity field is discussed. The detuning parameters and cross-Kerr nonlinearity are taken into account and it is assumed that atom-field coupling and Kerr medium to be $f$-deformed. Even though the system seems to be complicated, the analytical form of the state vector of the entire system for considered model is exactly obtained. The time evolution of nonclassical properties such as quantum entanglement and position-momentum entropic uncertainty relation (entropy squeezing) of the field are investigated. In each case, the influences of the detuning parameters, generalized Kerr medium and intensity-dependent coupling on the latter nonclassicality signs are analyzed, in detail.

An implementation of the QMR method based on coupled two-term recurrences

NASA Technical Reports Server (NTRS)

Freund, Roland W.; Nachtigal, Noeel M.

1992-01-01

The authors have proposed a new Krylov subspace iteration, the quasi-minimal residual algorithm (QMR), for solving non-Hermitian linear systems. In the original implementation of the QMR method, the Lanczos process with look-ahead is used to generate basis vectors for the underlying Krylov subspaces. In the Lanczos algorithm, these basis vectors are computed by means of three-term recurrences. It has been observed that, in finite precision arithmetic, vector iterations based on three-term recursions are usually less robust than mathematically equivalent coupled two-term vector recurrences. This paper presents a look-ahead algorithm that constructs the Lanczos basis vectors by means of coupled two-term recursions. Implementation details are given, and the look-ahead strategy is described. A new implementation of the QMR method, based on this coupled two-term algorithm, is described. A simplified version of the QMR algorithm without look-ahead is also presented, and the special case of QMR for complex symmetric linear systems is considered. Results of numerical experiments comparing the original and the new implementations of the QMR method are reported.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Lin, C.T.

Linear and nonlinear photochemistries of 1,4-diazabicyclo(2.2.2)octane (DABCO) are investigated at room temperature by using ArF (193 nm) and KrF (248 nm) lasers. With an unfocused beam geometry, DABCO vapor displays a strong fluorescence when excited at 248 nm, but it shows no detectable emission with 193-nm excitation. The linear photochemistry quantum yield for DABCO is determined as phi/sub p/(248nm) approx. 0.1 and phi/sub p/(193 nm) approx. 0.3. The main stable photochemical products are analyzed as C/sub 2/H/sub 4/ and C/sub 2/H/sub 2/ for 248- and 193-nm excitation, respectively. When focused beam excitation is used, both ArF and KrF lasers dissociatemore » DABCO molecules and give three strong radical emissions of CN*(B vector /sup 2/..sigma.. ..-->.. X vector /sup 2/ ..sigma../sup +/), CH*(A vector /sup 2/..delta.. ..-->.. X vector /sup 2/II), and C/sub 2/*(D vector /sup 3/II/sub g/ ..-->.. a vector /sup 3/II/sub u/). The time behavior, the laser power dependence, and the sample pressure dependence of these emissive radicals are examined. The possible mechanisms for the Rydberg state photochemistry of DABCO are discussed.« less

Matter-coupled de Sitter supergravity

NASA Astrophysics Data System (ADS)

Kallosh, R. E.

2016-05-01

The de Sitter supergravity describes the interaction of supergravity with general chiral and vector multiplets and also one nilpotent chiral multiplet. The extra universal positive term in the potential, generated by the nilpotent multiplet and corresponding to the anti-D3 brane in string theory, is responsible for the de Sitter vacuum stability in these supergravity models. In the flat-space limit, these supergravity models include the Volkov-Akulov model with a nonlinearly realized supersymmetry. We generalize the rules for constructing the pure de Sitter supergravity action to the case of models containing other matter multiplets. We describe a method for deriving the closed-form general supergravity action with a given potential K, superpotential W, and vectormatrix fAB interacting with a nilpotent chiral multiplet. It has the potential V = eK(|F2|+|DW|2-3|W|2), where F is the auxiliary field of the nilpotent multiplet and is necessarily nonzero. The de Sitter vacuums are present under the simple condition that |F2|-3|W|2 > 0. We present an explicit form of the complete action in the unitary gauge.

Constraints on muon-specific dark forces

NASA Astrophysics Data System (ADS)

Karshenboim, Savely G.; McKeen, David; Pospelov, Maxim

2014-10-01

The recent measurement of the Lamb shift in muonic hydrogen allows for the most precise extraction of the charge radius of the proton which is currently in conflict with other determinations based on e-p scattering and hydrogen spectroscopy. This discrepancy could be the result of some new muon-specific force with O(1-100) MeV force carrier—in this paper we concentrate on vector mediators. Such an explanation faces challenges from the constraints imposed by the g-2 of the muon and electron as well as precision spectroscopy of muonic atoms. In this work we complement the family of constraints by calculating the contribution of hypothetical forces to the muonium hyperfine structure. We also compute the two-loop contribution to the electron parity-violating amplitude due to a muon loop, which is sensitive to the muon axial-vector coupling. Overall, we find that the combination of low-energy constraints favors the mass of the mediator to be below 10 MeV and that a certain degree of tuning is required between vector and axial-vector couplings of new vector particles to muons in order to satisfy constraints from muon g-2. However, we also observe that in the absence of a consistent standard model embedding high-energy weak-charged processes accompanied by the emission of new vector particles are strongly enhanced by (E/mV)2, with E a characteristic energy scale and mV the mass of the mediator. In particular, leptonic W decays impose the strongest constraints on such models completely disfavoring the remainder of the parameter space.

Aviation Trainer Technology Test Plan. Volume II. Software Development

DTIC Science & Technology

1991-11-25

feild values in new node *Ieg>X=x newg->X = Y newg->Len =len; newg->Help =help; newg->Ignore = ignore; newg->Format = format; newg->Validation - NULL;I... vector : North long varVFE; /* F-16A velocity vector : East long varVFU; /* F-16A velocity vector : Up */ long varH; /* plane heading */ long varC; /* plane...31\\\\ETH523.sys" parmsdr.args=getds(); parmsdr.non7=OxOO; /*save interrupt vector for future restoration */ cSavvecso; rc=getdso; rc=cInitParameters

Informing the Human Plasma Protein Binding of Environmental Chemicals by Machine Learning in the Pharmaceutical Space: Applicability Domain and Limits of Predictability.

PubMed

Ingle, Brandall L; Veber, Brandon C; Nichols, John W; Tornero-Velez, Rogelio

2016-11-28

The free fraction of a xenobiotic in plasma (F ub ) is an important determinant of chemical adsorption, distribution, metabolism, elimination, and toxicity, yet experimental plasma protein binding data are scarce for environmentally relevant chemicals. The presented work explores the merit of utilizing available pharmaceutical data to predict F ub for environmentally relevant chemicals via machine learning techniques. Quantitative structure-activity relationship (QSAR) models were constructed with k nearest neighbors (kNN), support vector machines (SVM), and random forest (RF) machine learning algorithms from a training set of 1045 pharmaceuticals. The models were then evaluated with independent test sets of pharmaceuticals (200 compounds) and environmentally relevant ToxCast chemicals (406 total, in two groups of 238 and 168 compounds). The selection of a minimal feature set of 10-15 2D molecular descriptors allowed for both informative feature interpretation and practical applicability domain assessment via a bounded box of descriptor ranges and principal component analysis. The diverse pharmaceutical and environmental chemical sets exhibit similarities in terms of chemical space (99-82% overlap), as well as comparable bias and variance in constructed learning curves. All the models exhibit significant predictability with mean absolute errors (MAE) in the range of 0.10-0.18F ub . The models performed best for highly bound chemicals (MAE 0.07-0.12), neutrals (MAE 0.11-0.14), and acids (MAE 0.14-0.17). A consensus model had the highest accuracy across both pharmaceuticals (MAE 0.151-0.155) and environmentally relevant chemicals (MAE 0.110-0.131). The inclusion of the majority of the ToxCast test sets within the AD of the consensus model, coupled with high prediction accuracy for these chemicals, indicates the model provides a QSAR for F ub that is broadly applicable to both pharmaceuticals and environmentally relevant chemicals.

Catalytic-site design for inverse heavy-enzyme isotope effects in human purine nucleoside phosphorylase

PubMed Central

Harijan, Rajesh K.; Zoi, Ioanna; Antoniou, Dimitri; Schwartz, Steven D.; Schramm, Vern L.

2017-01-01

Heavy-enzyme isotope effects (15N-, 13C-, and 2H-labeled protein) explore mass-dependent vibrational modes linked to catalysis. Transition path-sampling (TPS) calculations have predicted femtosecond dynamic coupling at the catalytic site of human purine nucleoside phosphorylase (PNP). Coupling is observed in heavy PNPs, where slowed barrier crossing caused a normal heavy-enzyme isotope effect (kchem light/kchem heavy > 1.0). We used TPS to design mutant F159Y PNP, predicted to improve barrier crossing for heavy F159Y PNP, an attempt to generate a rare inverse heavy-enzyme isotope effect (kchem light/kchem heavy < 1.0). Steady-state kinetic comparison of light and heavy native PNPs to light and heavy F159Y PNPs revealed similar kinetic properties. Pre–steady-state chemistry was slowed 32-fold in F159Y PNP. Pre–steady-state chemistry compared heavy and light native and F159Y PNPs and found a normal heavy-enzyme isotope effect of 1.31 for native PNP and an inverse effect of 0.75 for F159Y PNP. Increased isotopic mass in F159Y PNP causes more efficient transition state formation. Independent validation of the inverse isotope effect for heavy F159Y PNP came from commitment to catalysis experiments. Most heavy enzymes demonstrate normal heavy-enzyme isotope effects, and F159Y PNP is a rare example of an inverse effect. Crystal structures and TPS dynamics of native and F159Y PNPs explore the catalytic-site geometry associated with these catalytic changes. Experimental validation of TPS predictions for barrier crossing establishes the connection of rapid protein dynamics and vibrational coupling to enzymatic transition state passage. PMID:28584087

Tadpole-induced electroweak symmetry breaking and pNGB Higgs models

DOE Office of Scientific and Technical Information (OSTI.GOV)

Harnik, Roni; Howe, Kiel; Kearney, John

We investigate induced electroweak symmetry breaking (EWSB) in models in which the Higgs is a pseudo-Nambu-Goldstone boson (pNGB). In pNGB Higgs models, Higgs properties and precision electroweak measurements imply a hierarchy between the EWSB and global symmetry-breaking scales,more » $$v_H \\ll f_H$$. When the pNGB potential is generated radiatively, this hierarchy requires fine-tuning to a degree of at least $$\\sim v_H^2/f_H^2$$. We show that if Higgs EWSB is induced by a tadpole arising from an auxiliary sector at scale $$f_\\Sigma \\ll v_H$$, this tuning is significantly ameliorated or can even be removed. We present explicit examples both in Twin Higgs models and in Composite Higgs models based on $SO(5)/SO(4)$. For the Twin case, the result is a fully natural model with $$f_H \\sim 1$$ TeV and the lightest colored top partners at 2 TeV. These models also have an appealing mechanism to generate the scales of the auxiliary sector and Higgs EWSB directly from the scale $$f_H$$, with a natural hierarchy $$f_\\Sigma \\ll v_H \\ll f_H \\sim{\\rm TeV}$$. Finally, the framework predicts modified Higgs coupling as well as new Higgs and vector states at LHC13.« less

Tadpole-induced electroweak symmetry breaking and pNGB Higgs models

DOE PAGES

Harnik, Roni; Howe, Kiel; Kearney, John

2017-03-22

We investigate induced electroweak symmetry breaking (EWSB) in models in which the Higgs is a pseudo-Nambu-Goldstone boson (pNGB). In pNGB Higgs models, Higgs properties and precision electroweak measurements imply a hierarchy between the EWSB and global symmetry-breaking scales,more » $$v_H \\ll f_H$$. When the pNGB potential is generated radiatively, this hierarchy requires fine-tuning to a degree of at least $$\\sim v_H^2/f_H^2$$. We show that if Higgs EWSB is induced by a tadpole arising from an auxiliary sector at scale $$f_\\Sigma \\ll v_H$$, this tuning is significantly ameliorated or can even be removed. We present explicit examples both in Twin Higgs models and in Composite Higgs models based on $SO(5)/SO(4)$. For the Twin case, the result is a fully natural model with $$f_H \\sim 1$$ TeV and the lightest colored top partners at 2 TeV. These models also have an appealing mechanism to generate the scales of the auxiliary sector and Higgs EWSB directly from the scale $$f_H$$, with a natural hierarchy $$f_\\Sigma \\ll v_H \\ll f_H \\sim{\\rm TeV}$$. Finally, the framework predicts modified Higgs coupling as well as new Higgs and vector states at LHC13.« less

Floating point only SIMD instruction set architecture including compare, select, Boolean, and alignment operations

DOEpatents

Gschwind, Michael K [Chappaqua, NY

2011-03-01

Mechanisms for implementing a floating point only single instruction multiple data instruction set architecture are provided. A processor is provided that comprises an issue unit, an execution unit coupled to the issue unit, and a vector register file coupled to the execution unit. The execution unit has logic that implements a floating point (FP) only single instruction multiple data (SIMD) instruction set architecture (ISA). The floating point vector registers of the vector register file store both scalar and floating point values as vectors having a plurality of vector elements. The processor may be part of a data processing system.

Nanodiamonds coupled with 5,7-dimethoxycoumarin, a plant bioactive metabolite, interfere with the mitotic process in B16F10 cells altering the actin organization.

PubMed

Gismondi, Angelo; Nanni, Valentina; Reina, Giacomo; Orlanducci, Silvia; Terranova, Maria Letizia; Canini, Antonella

2016-01-01

For the first time, we coupled reduced detonation nanodiamonds (NDs) with a plant secondary metabolite, citropten (5,7-dimethoxycoumarin), and demonstrated how this complex was able to reduce B16F10 tumor cell growth more effectively than treatment with the pure molecule. These results encouraged us to find out the specific mechanism underlying this phenomenon. Internalization kinetics and quantification of citropten in cells after treatment with its pure or ND-conjugated form were measured, and it was revealed that the coupling between NDs and citropten was essential for the biological properties of the complex. We showed that the adduct was not able to induce apoptosis, senescence, or differentiation, but it determined cell cycle arrest, morphological changes, and alteration of mRNA levels of the cytoskeletal-related genes. The identification of metaphasic nuclei and irregular disposition of β-actin in the cell cytoplasm supported the hypothesis that citropten conjugated with NDs showed antimitotic properties in B16F10 cells. This work can be considered a pioneering piece of research that could promote and support the biomedical use of plant drug-functionalized NDs in cancer therapy.

Nanodiamonds coupled with 5,7-dimethoxycoumarin, a plant bioactive metabolite, interfere with the mitotic process in B16F10 cells altering the actin organization

PubMed Central

Gismondi, Angelo; Nanni, Valentina; Reina, Giacomo; Orlanducci, Silvia; Terranova, Maria Letizia; Canini, Antonella

2016-01-01

For the first time, we coupled reduced detonation nanodiamonds (NDs) with a plant secondary metabolite, citropten (5,7-dimethoxycoumarin), and demonstrated how this complex was able to reduce B16F10 tumor cell growth more effectively than treatment with the pure molecule. These results encouraged us to find out the specific mechanism underlying this phenomenon. Internalization kinetics and quantification of citropten in cells after treatment with its pure or ND-conjugated form were measured, and it was revealed that the coupling between NDs and citropten was essential for the biological properties of the complex. We showed that the adduct was not able to induce apoptosis, senescence, or differentiation, but it determined cell cycle arrest, morphological changes, and alteration of mRNA levels of the cytoskeletal-related genes. The identification of metaphasic nuclei and irregular disposition of β-actin in the cell cytoplasm supported the hypothesis that citropten conjugated with NDs showed antimitotic properties in B16F10 cells. This work can be considered a pioneering piece of research that could promote and support the biomedical use of plant drug-functionalized NDs in cancer therapy. PMID:26893562

All-fiber radially/azimuthally polarized lasers based on mode coupling of tapered fibers.

PubMed

Mao, Dong; He, Zhiwen; Lu, Hua; Li, Mingkun; Zhang, Wending; Cui, Xiaoqi; Jiang, Biqiang; Zhao, Jianlin

2018-04-01

We demonstrate a mode converter with an insertion loss of 0.36 dB based on mode coupling of tapered single-mode and two-mode fibers, and realize all-fiber flexible cylindrical vector lasers at 1550 nm. Attributing to the continuous distribution of a tangential electric field at taper boundaries, the laser is switchable between the radially and azimuthally polarized states by adjusting the input polarization. In the temporal domain, the operation is controllable among continuous-wave, Q-switched, and mode-locked statuses by changing the saturable absorber or pump strength. The duration of Q-switched radially/azimuthally polarized laser spans from 10.4/10.8 to 6/6.4 μs at the pump range of 38 to 58 mW, while that of the mode-locked pulse varies from 39.2/31.9 to 5.6/5.2 ps by controlling the laser bandwidth. The proposed laser combines the features of a cylindrical vector beam, a fiber laser, and an ultrafast pulse, providing a special and cost-effective source for practical applications.

Influence of a repulsive vector coupling in magnetized quark matter

NASA Astrophysics Data System (ADS)

Denke, Robson Z.; Pinto, Marcus Benghi

2013-09-01

We consider two flavor magnetized quark matter in the presence of a repulsive vector coupling (GV) devoting special attention to the low temperature region of the phase diagram to show how this type of interaction counterbalances the effects produced by a strong magnetic field. The most important effects occur at intermediate and low temperatures affecting the location of the critical end point as well as the region of first order chiral transitions. When GV=0 the presence of high magnetic fields (eB≥10mπ2) increases the density coexistence region with respect to the case when B and GV are absent while a decrease of this region is observed at high GV values and vanishing magnetic fields. Another interesting aspect observed at the low temperature region is that the usual decrease of the coexistence chemical value (inverse magnetic catalysis) at GV=0 is highly affected by the presence of the vector interaction which acts in the opposite way. Our investigation also shows that the presence of a repulsive vector interaction enhances the de Haas-van Alphen oscillations which, for very low temperatures, take place at eB≲6mπ2. We observe that the presence of a magnetic field, together with a repulsive vector interaction, gives rise to a complex transition pattern since B favors the appearance of multiple solutions to the gap equation whereas GV turns some metastable solutions into stable ones allowing for a cascade of transitions to occur.

Thrust vectoring for lateral-directional stability

NASA Technical Reports Server (NTRS)

Peron, Lee R.; Carpenter, Thomas

1992-01-01

The advantages and disadvantages of using thrust vectoring for lateral-directional control and the effects of reducing the tail size of a single-engine aircraft were investigated. The aerodynamic characteristics of the F-16 aircraft were generated by using the Aerodynamic Preliminary Analysis System II panel code. The resulting lateral-directional linear perturbation analysis of a modified F-16 aircraft with various tail sizes and yaw vectoring was performed at several speeds and altitudes to determine the stability and control trends for the aircraft compared to these trends for a baseline aircraft. A study of the paddle-type turning vane thrust vectoring control system as used on the National Aeronautics and Space Administration F/A-18 High Alpha Research Vehicle is also presented.

The APEX experiment at JLab. Searching for the vector boson A' decaying to e+e-

NASA Astrophysics Data System (ADS)

Franklin, Gregg B.

2017-04-01

Jefferson Lab's A' Experiment (APEX) will search for a new vector boson, the A', in the mass range 65 MeV < mA' < 550 MeV, with sensitivity for the A' coupling to electrons of α' > 6 × 10-8α, where α = e2/4π. New vector bosons with such small couplings arise naturally from a small kinetic mixing of the "dark photon", A', with the photon — one of the very few ways in which new forces can couple to the Standard Model — and have received considerable attention as an explanation of various dark-matter related anomalies. In this experiment, A' bosons produced by radiation off an electron beam could appear as narrow resonances with small production cross-sections in the e+e- invariant mass distribution. The two Jefferson Lab HRS spectrometers will provide a reconstructed invariant-mass resolution for the A' of δM/M < 0.5%. With a 33-day run, the experiment will achieve high sensitivity by taking advantage of this mass resolution and high statistics of the e+e- pairs, which will be orders of magnitude larger than in previous searches for the A' boson in this mass range. This paper will review the key concepts of the experiment and the status of the preparations for running APEX. The results of a completed pilot run will be presented.

ASTROPHYSICS. Exclusion of leptophilic dark matter models using XENON100 electronic recoil data.

PubMed

2015-08-21

Laboratory experiments searching for galactic dark matter particles scattering off nuclei have so far not been able to establish a discovery. We use data from the XENON100 experiment to search for dark matter interacting with electrons. With no evidence for a signal above the low background of our experiment, we exclude a variety of representative dark matter models that would induce electronic recoils. For axial-vector couplings to electrons, we exclude cross sections above 6 × 10(-35) cm(2) for particle masses of m(χ) = 2 GeV/c(2). Independent of the dark matter halo, we exclude leptophilic models as an explanation for the long-standing DAMA/LIBRA signal, such as couplings to electrons through axial-vector interactions at a 4.4σ confidence level, mirror dark matter at 3.6σ, and luminous dark matter at 4.6σ. Copyright © 2015, American Association for the Advancement of Science.

Switching of bound vector solitons for the coupled nonlinear Schrödinger equations with nonhomogenously stochastic perturbations

NASA Astrophysics Data System (ADS)

Sun, Zhi-Yuan; Gao, Yi-Tian; Yu, Xin; Liu, Ying

2012-12-01

We investigate the dynamics of the bound vector solitons (BVSs) for the coupled nonlinear Schrödinger equations with the nonhomogenously stochastic perturbations added on their dispersion terms. Soliton switching (besides soliton breakup) can be observed between the two components of the BVSs. Rate of the maximum switched energy (absolute values) within the fixed propagation distance (about 10 periods of the BVSs) enhances in the sense of statistics when the amplitudes of stochastic perturbations increase. Additionally, it is revealed that the BVSs with enhanced coherence are more robust against the perturbations with nonhomogenous stochasticity. Diagram describing the approximate borders of the splitting and non-splitting areas is also given. Our results might be helpful in dynamics of the BVSs with stochastic noises in nonlinear optical fibers or with stochastic quantum fluctuations in Bose-Einstein condensates.

Switching of bound vector solitons for the coupled nonlinear Schrödinger equations with nonhomogenously stochastic perturbations.

PubMed

Sun, Zhi-Yuan; Gao, Yi-Tian; Yu, Xin; Liu, Ying

2012-12-01

We investigate the dynamics of the bound vector solitons (BVSs) for the coupled nonlinear Schrödinger equations with the nonhomogenously stochastic perturbations added on their dispersion terms. Soliton switching (besides soliton breakup) can be observed between the two components of the BVSs. Rate of the maximum switched energy (absolute values) within the fixed propagation distance (about 10 periods of the BVSs) enhances in the sense of statistics when the amplitudes of stochastic perturbations increase. Additionally, it is revealed that the BVSs with enhanced coherence are more robust against the perturbations with nonhomogenous stochasticity. Diagram describing the approximate borders of the splitting and non-splitting areas is also given. Our results might be helpful in dynamics of the BVSs with stochastic noises in nonlinear optical fibers or with stochastic quantum fluctuations in Bose-Einstein condensates.

Transformation volume effect on the magnetic anisotropy of Ni-Mn-Ga thin films

NASA Astrophysics Data System (ADS)

L'vov, V. A.; Golub, V.; Salyuk, O.; Barandiarán, J. M.; Chernenko, V. A.

2015-01-01

Ni-Mn-Ga ferromagnetic shape memory films with similar thickness and chemical composition, deposited onto cold (with a subsequent annealing) and hot MgO(001) substrates exhibit different internal stress and structure giving rise to a different orientation of the magnetic easy axes. A quantitative theoretical analysis of the crystallographic and ferromagnetic resonance (FMR) data shows that the different anisotropies can be caused by the difference in sign between the transformation volume changes in these films, as influenced by the internal stresses. To explain FMR data, the magnetoelastic coupling term of fourth-order in the magnetic vector and linear in the strain tensor components, appearing in the Landau expansion for the free energy, is taken into account. The coefficient of the term, which couples the magnetic vector components with the volume change of the Ni-Mn-Ga alloy, was estimated to be equal to about 10 7 erg cm - 3 .

Selected Performance Measurements of the F-15 Active Axisymmetric Thrust-vectoring Nozzle

NASA Technical Reports Server (NTRS)

Orme, John S.; Sims, Robert L.

1998-01-01

Flight tests recently completed at the NASA Dryden Flight Research Center evaluated performance of a hydromechanically vectored axisymmetric nozzle onboard the F-15 ACTIVE. A flight-test technique whereby strain gages installed onto engine mounts provided for the direct measurement of thrust and vector forces has proven to be extremely valuable. Flow turning and thrust efficiency, as well as nozzle static pressure distributions were measured and analyzed. This report presents results from testing at an altitude of 30,000 ft and a speed of Mach 0.9. Flow turning and thrust efficiency were found to be significantly different than predicted, and moreover, varied substantially with power setting and pitch vector angle. Results of an in-flight comparison of the direct thrust measurement technique and an engine simulation fell within the expected uncertainty bands. Overall nozzle performance at this flight condition demonstrated the F100-PW-229 thrust-vectoring nozzles to be highly capable and efficient.

Selected Performance Measurements of the F-15 ACTIVE Axisymmetric Thrust-Vectoring Nozzle

NASA Technical Reports Server (NTRS)

Orme, John S.; Sims, Robert L.

1999-01-01

Flight tests recently completed at the NASA Dryden Flight Research Center evaluated performance of a hydromechanically vectored axisymmetric nozzle onboard the F-15 ACTIVE. A flight-test technique whereby strain gages installed onto engine mounts provided for the direct measurement of thrust and vector forces has proven to be extremely valuable. Flow turning and thrust efficiency, as well as nozzle static pressure distributions were measured and analyzed. This report presents results from testing at an altitude of 30,000 ft and a speed of Mach 0.9. Flow turning and thrust efficiency were found to be significantly different than predicted, and moreover, varied substantially with power setting and pitch vector angle. Results of an in-flight comparison of the direct thrust measurement technique and an engine simulation fell within the expected uncertainty bands. Overall nozzle performance at this flight condition demonstrated the F100-PW-229 thrust-vectoring nozzles to be highly capable and efficient.

Improved dual AAV vectors with reduced expression of truncated proteins are safe and effective in the retina of a mouse model of Stargardt disease

PubMed Central

Trapani, Ivana; Toriello, Elisabetta; de Simone, Sonia; Colella, Pasqualina; Iodice, Carolina; Polishchuk, Elena V.; Sommella, Andrea; Colecchi, Linda; Rossi, Settimio; Simonelli, Francesca; Giunti, Massimo; Bacci, Maria L.; Polishchuk, Roman S.; Auricchio, Alberto

2015-01-01

Stargardt disease (STGD1) due to mutations in the large ABCA4 gene is the most common inherited macular degeneration in humans. We have shown that dual adeno-associated viral (AAV) vectors effectively transfer ABCA4 to the retina of Abca4−/− mice. However, they express both lower levels of transgene compared with a single AAV and truncated proteins. To increase productive dual AAV concatemerization, which would overcome these limitations, we have explored the use of either various regions of homology or heterologous inverted terminal repeats (ITR). In addition, we tested the ability of various degradation signals to decrease the expression of truncated proteins. We found the highest levels of transgene expression using regions of homology based on either alkaline phosphatase or the F1 phage (AK). The use of heterologous ITR does not decrease the levels of truncated proteins relative to full-length ABCA4 and impairs AAV vector production. Conversely, the inclusion of the CL1 degradation signal results in the selective degradation of truncated proteins from the 5′-half without affecting full-length protein production. Therefore, we developed dual AAV hybrid ABCA4 vectors including homologous ITR2, the photoreceptor-specific G protein-coupled receptor kinase 1 promoter, the AK region of homology and the CL1 degradation signal. We show that upon subretinal administration these vectors are both safe in pigs and effective in Abca4−/− mice. Our data support the use of improved dual AAV vectors for gene therapy of STGD1. PMID:26420842

Modification to the Capsid of the Adenovirus Vector That Enhances Dendritic Cell Infection and Transgene-Specific Cellular Immune Responses

PubMed Central

Worgall, Stefan; Busch, Annette; Rivara, Michael; Bonnyay, David; Leopold, Philip L.; Merritt, Robert; Hackett, Neil R.; Rovelink, Peter W.; Bruder, Joseph T.; Wickham, Thomas J.; Kovesdi, Imi; Crystal, Ronald G.

2004-01-01

Adenovirus (Ad) gene transfer vectors can be used to transfer and express antigens and function as strong adjuvants and thus are useful platforms for the development of genetic vaccines. Based on the hypothesis that Ad vectors with enhanced infectibility of dendritic cells (DC) may be able to evoke enhanced immune responses against antigens encoded by the vector in vivo, the present study analyzes the vaccine potential of an Ad vector expressing β-galactosidase as a model antigen and genetically modified with RGD on the fiber knob [AdZ.F(RGD)] to more selectively infect DC and consequently enhance immunity against the β-galactosidase antigen. Infection of murine DC in vitro with AdZ.F(RGD) showed an eightfold-increased transgene expression following infection compared to AdZ (also expressing β-galactosidase, but with a wild-type capsid). Binding, cellular uptake, and trafficking in DC were also increased with AdZ.F(RGD) compared to AdZ. To determine whether AdZ.F(RGD) could evoke enhanced immune responses to β-galactosidase in vivo, C57BL/6 mice were immunized with AdZ.F(RGD) or AdZ subcutaneously via the footpad. Humoral responses with both vectors were comparable, with similar anti-β-galactosidase antibody levels following vector administration. However, cellular responses to β-galactosidase were significantly enhanced, with the frequency of CD4+ as well as the CD8+ β-galactosidase-specific gamma interferon response in cells isolated from the draining lymph nodes increased following immunization with AdZ.F(RGD) compared to Ad.Z (P < 0.01). Importantly, this enhanced cellular immune response of the AdZ.F(RGD) vector was sufficient to evoke enhanced inhibition of the growth of preexisting tumors expressing β-galactosidase: BALB/c mice implanted with the CT26 syngeneic β-galactosidase-expressing colon carcinoma cell line and subsequently immunized with AdZ.F(RGD) showed decreased tumor growth and improved survival compared to mice immunized with AdZ. These data demonstrate that addition of an RGD motif to the Ad fiber knob increases the infectibility of DC and leads to enhanced cellular immune responses to the Ad-transferred transgene, suggesting that the RGD capsid modification may be useful in developing Ad-based vaccines. PMID:14963160

Spectrally efficient digitized radio-over-fiber system with k-means clustering-based multidimensional quantization.

PubMed

Zhang, Lu; Pang, Xiaodan; Ozolins, Oskars; Udalcovs, Aleksejs; Popov, Sergei; Xiao, Shilin; Hu, Weisheng; Chen, Jiajia

2018-04-01

We propose a spectrally efficient digitized radio-over-fiber (D-RoF) system by grouping highly correlated neighboring samples of the analog signals into multidimensional vectors, where the k-means clustering algorithm is adopted for adaptive quantization. A 30  Gbit/s D-RoF system is experimentally demonstrated to validate the proposed scheme, reporting a carrier aggregation of up to 40 100 MHz orthogonal frequency division multiplexing (OFDM) channels with quadrate amplitude modulation (QAM) order of 4 and an aggregation of 10 100 MHz OFDM channels with a QAM order of 16384. The equivalent common public radio interface rates from 37 to 150  Gbit/s are supported. Besides, the error vector magnitude (EVM) of 8% is achieved with the number of quantization bits of 4, and the EVM can be further reduced to 1% by increasing the number of quantization bits to 7. Compared with conventional pulse coding modulation-based D-RoF systems, the proposed D-RoF system improves the signal-to-noise-ratio up to ∼9  dB and greatly reduces the EVM, given the same number of quantization bits.

Serendipity in dark photon searches

NASA Astrophysics Data System (ADS)

Ilten, Philip; Soreq, Yotam; Williams, Mike; Xue, Wei

2018-06-01

Searches for dark photons provide serendipitous discovery potential for other types of vector particles. We develop a framework for recasting dark photon searches to obtain constraints on more general theories, which includes a data-driven method for determining hadronic decay rates. We demonstrate our approach by deriving constraints on a vector that couples to the B-L current, a leptophobic B boson that couples directly to baryon number and to leptons via B- γ kinetic mixing, and on a vector that mediates a protophobic force. Our approach can easily be generalized to any massive gauge boson with vector couplings to the Standard Model fermions, and software to perform any such recasting is provided at https://gitlab.com/philten/darkcast .

Betatron motion with coupling of horizontal and vertical degrees of freedom

DOE PAGES

Lebedev, V. A.; Bogacz, S. A.

2010-10-21

Presently, there are two most frequently used parameterezations of linear x-y coupled motion used in the accelerator physics. They are the Edwards-Teng and Mais-Ripken parameterizations. The article is devoted to an analysis of close relationship between the two representations, thus adding a clarity to their physical meaning. It also discusses the relationship between the eigen-vectors, the beta-functions, second order moments and the bilinear form representing the particle ellipsoid in the 4D phase space. Then, it consideres a further development of Mais-Ripken parameteresation where the particle motion is descrabed by 10 parameters: four beta-functions, four alpha-functions and two betatron phase advances.more » In comparison with Edwards-Teng parameterization the chosen parametrization has an advantage that it works equally well for analysis of coupled betatron motion in circular accelerators and in transfer lines. In addition, considered relationship between second order moments, eigen-vectors and beta-functions can be useful in interpreting tracking results and experimental data. As an example, the developed formalizm is applied to the FNAL electron cooler and Derbenev’s vertex-to-plane adapter.« less

Betatron motion with coupling of horizontal and vertical degrees of freedom

DOE Office of Scientific and Technical Information (OSTI.GOV)

Lebedev, V. A.; Bogacz, S. A.

Presently, there are two most frequently used parameterezations of linear x-y coupled motion used in the accelerator physics. They are the Edwards-Teng and Mais-Ripken parameterizations. The article is devoted to an analysis of close relationship between the two representations, thus adding a clarity to their physical meaning. It also discusses the relationship between the eigen-vectors, the beta-functions, second order moments and the bilinear form representing the particle ellipsoid in the 4D phase space. Then, it consideres a further development of Mais-Ripken parameteresation where the particle motion is descrabed by 10 parameters: four beta-functions, four alpha-functions and two betatron phase advances.more » In comparison with Edwards-Teng parameterization the chosen parametrization has an advantage that it works equally well for analysis of coupled betatron motion in circular accelerators and in transfer lines. In addition, considered relationship between second order moments, eigen-vectors and beta-functions can be useful in interpreting tracking results and experimental data. As an example, the developed formalizm is applied to the FNAL electron cooler and Derbenev’s vertex-to-plane adapter.« less

Betatron motion with coupling of horizontal and vertical degrees of freedom

DOE Office of Scientific and Technical Information (OSTI.GOV)

Lebedev, V.A.; /Fermilab; Bogacz, S.A.

Presently, there are two most frequently used parameterizations of linear x-y coupled motion used in the accelerator physics. They are the Edwards-Teng and Mais-Ripken parameterizations. The article is devoted to an analysis of close relationship between the two representations, thus adding a clarity to their physical meaning. It also discusses the relationship between the eigen-vectors, the beta-functions, second order moments and the bilinear form representing the particle ellipsoid in the 4D phase space. Then, it consideres a further development of Mais-Ripken parameteresation where the particle motion is described by 10 parameters: four beta-functions, four alpha-functions and two betatron phase advances.more » In comparison with Edwards-Teng parameterization the chosen parametrization has an advantage that it works equally well for analysis of coupled betatron motion in circular accelerators and in transfer lines. Considered relationship between second order moments, eigen-vectors and beta-functions can be useful in interpreting tracking results and experimental data. As an example, the developed formalizm is applied to the FNAL electron cooler and Derbenev's vertex-to-plane adapter.« less

Characterization of Hadamard vector classes in terms of least deviations of their elements from vectors of finite degree

DOE Office of Scientific and Technical Information (OSTI.GOV)

Radzievski, G V

2001-12-31

Let A be a linear operator with domain D(A) in a complex Banach space X. An element g element of D{sub {infinity}}(A):=intersection{sub j=1}{sup {infinity}}D(A{sup j}) is called a vector of degree at most {xi} (>0) relative to A if ||A{sup j}g||{<=}c(g){xi}{sup j}, j=0,1,.... The set of vectors of degree at most {xi} is denoted by G{sub {xi}}(A) and the least deviation of an element f of X from the set G{sub {xi}}(A) is denoted by E{sub {xi}}(f,A). For a fixed sequence of positive numbers ({psi}{sub j}){sub j=1}{sup {infinity}} consider a function {gamma}({xi}):=min{sub j=1,2,...}({xi}{psi}{sub j}){sup 1/j}. Conditions for the sequence ({psi}{submore » j}){sub j=1}{sup {infinity}} and the operator A are found that ensure the equality lim sup{sub j{yields}}{sub {infinity}}((||A{sup j}f||)/({psi}{sub j})){sup 1/j} = lim sup{sub {xi}}{sub {yields}}{sub {infinity}}{xi}/({gamma}(E{sub {xi}}(f,A){sup -1})) for f element of D{sub {infinity}}(A). If the quantity on the left-hand side of this formula is finite, then f belongs to the Hadamard class determined by the operator A and the sequence {l_brace}{psi}{sub j}{r_brace}{sub j=1}{sup {infinity}}. One consequence of the above formula is an expression in terms of E{sub {xi}}(f,A) for the radius of holomorphy of the vector-valued function F(zA)f, where f element of D{sub {infinity}}(A), and F(z):={sigma}{sub j=1}{sup {infinity}}z{sup j}/{psi}{sub j} is an entire function.« less

The Weak Gravity Conjecture and the axionic black hole paradox

NASA Astrophysics Data System (ADS)

Hebecker, Arthur; Soler, Pablo

2017-09-01

In theories with a perturbatively massless 2-form (dual to an axion), a paradox may arise in the process of black hole evaporation. Schwarzschild black holes can support a non-trivial Wilson-line-type field, the integral of the 2-form around their horizon. After such an `axionic black hole' evaporates, the Wilson line must be supported by the corresponding 3-form field strength in the region formerly occupied by the black hole. In the limit of small axion decay-constant f, the energy required for this field configuration is too large. Thus, energy cannot be conserved in the process of black hole evaporation. The natural resolution of this paradox is through the presence of light strings, which allow the black hole to "shed" its axionic hair sufficiently early. This gives rise to a new Weak-Gravity-type argument in the 2-form context: small coupling, in this case f , enforces the presence of light strings or a low cutoff. We also discuss how this argument may be modified in situations where the weak coupling regime is achieved in the low-energy effective theory through an appropriate gauging of a model with a vector field and two 2-forms.

Search for heavy vector-like quarks coupling to light quarks in proton–proton collisions at s = 7   TeV with the ATLAS detector

DOE PAGES

Aad, G.; Abbott, B.; Abdallah, J.; ...

2012-05-01

This Letter presents a search for singly produced vector-like quarks, Q, coupling to light quarks, q. The search is sensitive to both charged current (CC) and neutral current (NC) processes, pp→Qq→Wqq' and pp→Qq→Zqq' with a leptonic decay of the vector gauge boson. In 1.04fb -1 of data taken in 2011 by the ATLAS experiment at a center-of-mass energy √s=7TeV, no evidence of such heavy vector-like quarks is observed above the expected Standard Model background. Limits on the heavy vector-like quark production cross section times branching ratio as a function of mass m Q are obtained. For a coupling κ qQ=v/mmore » Q, where v is the Higgs vacuum expectation value, 95% C.L. lower limits on the mass of a vector-like quark are set at 900 GeV and 760 GeV from CC and NC processes, respectively.« less

Implementation details of the coupled QMR algorithm

NASA Technical Reports Server (NTRS)

Freund, Roland W.; Nachtigal, Noel M.

1992-01-01

The original quasi-minimal residual method (QMR) relies on the three-term look-ahead Lanczos process, to generate basis vectors for the underlying Krylov subspaces. However, empirical observations indicate that, in finite precision arithmetic, three-term vector recurrences are less robust than mathematically equivalent coupled two-term recurrences. Therefore, we recently proposed a new implementation of the QMR method based on a coupled two-term look-ahead Lanczos procedure. In this paper, we describe implementation details of this coupled QMR algorithm, and we present results of numerical experiments.

Parity-violating CMB correlators with non-decaying statistical anisotropy

DOE Office of Scientific and Technical Information (OSTI.GOV)

Bartolo, Nicola; Matarrese, Sabino; Shiraishi, Maresuke

2015-07-01

We examine the effect induced on cosmological correlators by the simultaneous breaking of parity and of statistical isotropy. As an example of this, we compute the scalar-scalar, scalar-tensor, tensor-tensor and scalar-scalar-scalar cosmological correlators in presence of the coupling L = f(φ) ( − 1/4 F{sup 2} + γ/4 F ∼F ) between the inflaton φ and a vector field with vacuum expectation value  A. For a suitably chosen function f, the energy in the vector field ρ{sub A} does not decay during inflation. This results in nearly scale-invariant signatures of broken statistical isotropy and parity. Specifically, we find that the scalar-scalar correlator of primordial curvature perturbations includes a quadrupolar anisotropy, P{submore » ζ}(k) = P(k)[1+g{sub *}( k-circumflex ⋅Â){sup 2}], and a (angle-averaged) scalar bispectrum that is a linear combination of the first 3 Legendre polynomials, B{sub ζ}(k{sub 1}, k{sub 2}, k{sub 3}) = ∑{sub L} c{sub L} P{sub L} ( k-circumflex {sub 1} ⋅  k-circumflex {sub 2}) P(k{sub 1}) P(k{sub 2}) + 2 perms , with c{sub 0}:c{sub 1}:c{sub 2}=2-3:1 (c{sub 1}≠0 is a consequence of parity violation, corresponding to the constant 0γ ≠ ). The latter is one of the main results of this paper, which provides for the first time a clear example of an inflationary model where a non-negligible c{sub 1} contribution to the bispectrum is generated. The scalar-tensor and tensor-tensor correlators induce characteristic signatures in the Cosmic Microwave Background temperature anisotropies (T) and polarization (E/B modes); namely, non-diagonal contributions to (a{sub ℓ1m1}a{sup *}{sub ℓ2m2}), with |ℓ{sub 1} − ℓ{sub 2}| = 1 in TT, TE, EE and BB, and |ℓ{sub 1} − ℓ{sub 2}| = 2 in TB and EB. The latest CMB bounds on the scalar observables (g{sub *}, c{sub 0}, c{sub 1} and c{sub 2}), translate into the upper limit ρ{sub A} / ρ{sub φ} ∼< 10{sup −9} at 0γ=. We find that the upper limit on the vector energy density becomes much more stringent as γ grows.« less

A Software Package for Neural Network Applications Development

NASA Technical Reports Server (NTRS)

Baran, Robert H.

1993-01-01

Original Backprop (Version 1.2) is an MS-DOS package of four stand-alone C-language programs that enable users to develop neural network solutions to a variety of practical problems. Original Backprop generates three-layer, feed-forward (series-coupled) networks which map fixed-length input vectors into fixed length output vectors through an intermediate (hidden) layer of binary threshold units. Version 1.2 can handle up to 200 input vectors at a time, each having up to 128 real-valued components. The first subprogram, TSET, appends a number (up to 16) of classification bits to each input, thus creating a training set of input output pairs. The second subprogram, BACKPROP, creates a trilayer network to do the prescribed mapping and modifies the weights of its connections incrementally until the training set is leaned. The learning algorithm is the 'back-propagating error correction procedures first described by F. Rosenblatt in 1961. The third subprogram, VIEWNET, lets the trained network be examined, tested, and 'pruned' (by the deletion of unnecessary hidden units). The fourth subprogram, DONET, makes a TSR routine by which the finished product of the neural net design-and-training exercise can be consulted under other MS-DOS applications.

Cell-cell signaling controls Xylella fastidiosa interactions with both insects and plants

PubMed Central

Newman, Karyn L.; Almeida, Rodrigo P. P.; Purcell, Alexander H.; Lindow, Steven E.

2004-01-01

Xylella fastidiosa, which causes Pierce's disease of grapevine and other important plant diseases, is a xylem-limited bacterium that depends on insect vectors for transmission. Although many studies have addressed disease symptom development and transmission of the pathogen by vectors, little is known about the bacterial mechanisms driving these processes. Recently available X. fastidiosa genomic sequences and molecular tools have provided new routes for investigation. Here, we show that a diffusible signal molecule is required for biofilm formation in the vector and for vector transmission to plants. We constructed strains of X. fastidiosa mutated in the rpfF gene and determined that they are unable to produce the signal activity. In addition, rpfF mutants are more virulent than the wild type when mechanically inoculated into plants. This signal therefore directs interaction of X. fastidiosa with both its insect vector and plant host. Interestingly, rpfF mutants can still form in planta biofilms, which differ architecturally from biofilms in insects, suggesting that biofilm architecture, rather than a passive response to the environment, is actively determined by X. fastidiosa gene expression. This article reports a cell-cell signaling requirement for vector transmission. Identification of the genes regulated by rpfF should elucidate bacterial factors involved in transmission and biofilm formation in the insect. PMID:14755059

Performance characteristics of a wedge nozzle installed on an F-18 propulsion wind tunnel model

NASA Technical Reports Server (NTRS)

Petit, J. E.; Capone, F. J.

1979-01-01

The results of two-dimensional wedge non-axisymmetric nozzle (2D-AIN) tests to determine its performance relative to the baseline axisymmetric nozzle using an F-18 jet effects wind tunnel model are presented. Configurations and test conditions simulated forward thrust-minus drag, thrust vectoring/induced lift, and thrust reversing flight conditions from Mach .6 to 1.20 and attack angles up to 10 degrees. Results of the model test program indicate that non-axisymmetric nozzles can be installed on a twin engine fighter aircraft model with equivalent thrust minus drag performance as the baseline axisymmetric nozzles. Thrust vectoring capability of the non-axisymmetric nozzles provided significant jet-induced lift on the nozzle/aftbody and horizontal tail surfaces. Thrust reversing panels deployed from the 2D-AIN centerbody wedge were very effective for static and inflight operation

Searching for new heavy neutral gauge bosons using vector boson fusion processes at the LHC

DOE PAGES

Flórez, Andrés; Gurrola, Alfredo; Johns, Will; ...

2017-02-01

Here, new massive resonances are predicted in many extensions to the Standard Model (SM) of particle physics and constitutes one of the most promising searches for new physics at the LHC. We present a feasibility study to search for new heavy neutral gauge bosons using vector boson fusion (VBF) processes, which become especially important as the LHC probes higher collision energies. In particular, we consider the possibility that the discovery of a Z' boson may have eluded searches at the LHC. The coupling of the Z' boson to the SM quarks can be small, and thus the Z' would notmore » be discoverable by the searches conducted thus far. In the context of a simplified phenomenological approach, we consider the Z'→ττ and Z'→μμ decay modes to show that the requirement of a dilepton pair combined with two high p T forward jets with large separation in pseudorapidity and with large dijet mass is effective in reducing SM backgrounds. The expected exclusion bounds (at 95% confidence level) are m(Z') < 1.8 TeV and m(Z')<2.5 TeV in the ττj fj f and μμj fj f channels, respectively, assuming 1000 fb –1 of 13 TeV data from the LHC. The use of the VBF topology to search for massive neutral gauge bosons provides a discovery reach with expected significances greater than 5σ (3σ) for Z' masses up to 1.4 (1.6) TeV and 2.0 (2.2) TeV in the ττj fj f and μμj fj f channels.« less

Stationary states of fermions in a sign potential with a mixed vector–scalar coupling

DOE Office of Scientific and Technical Information (OSTI.GOV)

Castilho, W.M., E-mail: castilho.w@gmail.com; Castro, A.S. de, E-mail: castro@pq.cnpq.br

2014-01-15

The scattering of a fermion in the background of a sign potential is considered with a general mixing of vector and scalar Lorentz structures with the scalar coupling stronger than or equal to the vector coupling under the Sturm–Liouville perspective. When the vector coupling and the scalar coupling have different magnitudes, an isolated solution shows that the fermion under a strong potential can be trapped in a highly localized region without manifestation of Klein’s paradox. It is also shown that the lonely bound-state solution disappears asymptotically as one approaches the conditions for the realization of spin and pseudospin symmetries. --more » Highlights: •Scattering of fermions in a sign potential assessed under a Sturm–Liouville perspective. •An isolated bounded solution. •No pair production despite the high localization. •No bounded solution under exact spin and pseudospin symmetries.« less

Research and simulation of the decoupling transformation in AC motor vector control

NASA Astrophysics Data System (ADS)

He, Jiaojiao; Zhao, Zhongjie; Liu, Ken; Zhang, Yongping; Yao, Tuozhong

2018-04-01

Permanent magnet synchronous motor (PMSM) is a nonlinear, strong coupling, multivariable complex object, and transformation decoupling can solve the coupling problem of permanent magnet synchronous motor. This paper gives a permanent magnet synchronous motor (PMSM) mathematical model, introduces the permanent magnet synchronous motor vector control coordinate transformation in the process of modal matrix inductance matrix transform through the matrix related knowledge of different coordinates of diagonalization, which makes the coupling between the independent, realize the control of motor current and excitation the torque current coupling separation, and derived the coordinate transformation matrix, the thought to solve the coupling problem of AC motor. Finally, in the Matlab/Simulink environment, through the establishment and combination between the PMSM ontology, coordinate conversion module, built the simulation model of permanent magnet synchronous motor vector control, introduces the model of each part, and analyzed the simulation results.

Concise synthesis of the hasubanan alkaloid (±)-cepharatine A using a Suzuki coupling reaction to effect o,p-phenolic coupling.

PubMed

Magnus, Philip; Seipp, Charles

2013-09-20

Suzuki coupling of 10 and 11 resulted in 9, which was O-alkylated to provide 12. Treatment of 12 with CsF in DMF resulted in the formation of the completed core structure 13 in a single step. Reductive amination of 13 completed the synthesis of (±)-cepharatine A, 4.

The potential for flower nectar to allow mosquito to mosquito transmission of Francisella tularensis

PubMed Central

Payne, Jessica; Gaughenbaugh, Anna; Renshaw, Andrea; Wright, Jenna; Seeber, Roger; Barnes, Rebecca; Florjanczyk, Aleksandr; Horzempa, Joseph

2017-01-01

Francisella tularensis is disseminated in nature by biting arthropods such as mosquitoes. The relationship between mosquitoes and F. tularensis in nature is highly ambiguous, due in part to the fact that mosquitoes have caused significant tularemia outbreaks despite being classified as a mechanical vector of F. tularensis. One possible explanation for mosquitoes being a prominent, yet mechanical vector is that these insects feed on flower nectar between blood meals, allowing for transmission of F. tularensis between mosquitoes. Here, we aimed to assess whether F. tularensis could survive in flower nectar. Moreover, we examined if mosquitoes could interact with or ingest and transmit F. tularensis from one source of nectar to another. F. tularensis exhibited robust survivability in flower nectar with concentrations of viable bacteria remaining consistent with the rich growth medium. Furthermore, F. tularensis was able to survive (albeit to a lesser extent) in 30% sucrose (a nectar surrogate) over a period of time consistent with that of a typical flower bloom. Although we observed diminished bacterial survival in the nectar surrogate, mosquitoes that fed on this material became colonized with F. tularensis. Finally, colonized mosquitoes were capable of transferring F. tularensis to a sterile nectar surrogate. These data suggest that flower nectar may be capable of serving as a temporary source of F. tularensis that could contribute to the amplification of outbreaks. Mosquitoes that feed on an infected mammalian host and subsequently feed on flower nectar could deposit some F. tularensis bacteria into the nectar in the process. Mosquitoes subsequently feeding on this nectar source could potentially become colonized by F. tularensis. Thus, the possibility exists that flower nectar may allow for vector-vector transmission of F. tularensis. PMID:28486521

The potential for flower nectar to allow mosquito to mosquito transmission of Francisella tularensis.

PubMed

Kenney, Adam; Cusick, Austin; Payne, Jessica; Gaughenbaugh, Anna; Renshaw, Andrea; Wright, Jenna; Seeber, Roger; Barnes, Rebecca; Florjanczyk, Aleksandr; Horzempa, Joseph

2017-01-01

Francisella tularensis is disseminated in nature by biting arthropods such as mosquitoes. The relationship between mosquitoes and F. tularensis in nature is highly ambiguous, due in part to the fact that mosquitoes have caused significant tularemia outbreaks despite being classified as a mechanical vector of F. tularensis. One possible explanation for mosquitoes being a prominent, yet mechanical vector is that these insects feed on flower nectar between blood meals, allowing for transmission of F. tularensis between mosquitoes. Here, we aimed to assess whether F. tularensis could survive in flower nectar. Moreover, we examined if mosquitoes could interact with or ingest and transmit F. tularensis from one source of nectar to another. F. tularensis exhibited robust survivability in flower nectar with concentrations of viable bacteria remaining consistent with the rich growth medium. Furthermore, F. tularensis was able to survive (albeit to a lesser extent) in 30% sucrose (a nectar surrogate) over a period of time consistent with that of a typical flower bloom. Although we observed diminished bacterial survival in the nectar surrogate, mosquitoes that fed on this material became colonized with F. tularensis. Finally, colonized mosquitoes were capable of transferring F. tularensis to a sterile nectar surrogate. These data suggest that flower nectar may be capable of serving as a temporary source of F. tularensis that could contribute to the amplification of outbreaks. Mosquitoes that feed on an infected mammalian host and subsequently feed on flower nectar could deposit some F. tularensis bacteria into the nectar in the process. Mosquitoes subsequently feeding on this nectar source could potentially become colonized by F. tularensis. Thus, the possibility exists that flower nectar may allow for vector-vector transmission of F. tularensis.

Flight-Determined, Subsonic, Lateral-Directional Stability and Control Derivatives of the Thrust-Vectoring F-18 High Angle of Attack Research Vehicle (HARV), and Comparisons to the Basic F-18 and Predicted Derivatives

NASA Technical Reports Server (NTRS)

Iliff, Kenneth W.; Wang, Kon-Sheng Charles

1999-01-01

The subsonic, lateral-directional, stability and control derivatives of the thrust-vectoring F-1 8 High Angle of Attack Research Vehicle (HARV) are extracted from flight data using a maximum likelihood parameter identification technique. State noise is accounted for in the identification formulation and is used to model the uncommanded forcing functions caused by unsteady aerodynamics. Preprogrammed maneuvers provided independent control surface inputs, eliminating problems of identifiability related to correlations between the aircraft controls and states. The HARV derivatives are plotted as functions of angles of attack between 10deg and 70deg and compared to flight estimates from the basic F-18 aircraft and to predictions from ground and wind tunnel tests. Unlike maneuvers of the basic F-18 aircraft, the HARV maneuvers were very precise and repeatable, resulting in tightly clustered estimates with small uncertainty levels. Significant differences were found between flight and prediction; however, some of these differences may be attributed to differences in the range of sideslip or input amplitude over which a given derivative was evaluated, and to differences between the HARV external configuration and that of the basic F-18 aircraft, upon which most of the prediction was based. Some HARV derivative fairings have been adjusted using basic F-18 derivatives (with low uncertainties) to help account for differences in variable ranges and the lack of HARV maneuvers at certain angles of attack.

Linear Test Bed. Volume 2: Test Bed No. 2. [linear aerospike test bed for thrust vector control

NASA Technical Reports Server (NTRS)

1974-01-01

Test bed No. 2 consists of 10 combustors welded in banks of 5 to 2 symmetrical tubular nozzle assemblies, an upper stationary thrust frame, a lower thrust frame which can be hinged, a power package, a triaxial combustion wave ignition system, a pneumatic control system, pneumatically actuated propellant valves, a purge and drain system, and an electrical control system. The power package consists of the Mark 29-F fuel turbopump, the Mark 29-0 oxidizer turbopump, a gas generator assembly, and propellant ducting. The system, designated as a linear aerospike system, was designed to demonstrate the feasibility of the concept and to explore technology related to thrust vector control, thrust vector optimization, improved sequencing and control, and advanced ignition systems. The propellants are liquid oxygen/liquid hydrogen. The system was designed to operate at 1200-psia chamber pressure at an engine mixture ratio of 5.5. With 10 combustors, the sea level thrust is 95,000 pounds.

Relativistic Quark Model Based Description of Low Energy NN Scattering

NASA Astrophysics Data System (ADS)

Antalik, R.; Lyubovitskij, V. E.

A model describing the NN scattering phase shifts is developed. Two nucleon interactions induced by meson exchange forces are constructed starting from π, η, η‧ pseudoscalar-, the ρ, ϕ, ω vector-, and the ɛ(600), a0, f0(1400) scalar — meson-nucleon coupling constants, which we obtained within a relativistic quantum field theory based quark model. Working within the Blankenbecler-Sugar-Logunov-Tavkhelidze quasipotential dynamics, we describe the NN phase shifts in a relativistically invariant way. In this procedure we use phenomenological form factor cutoff masses and effective ɛ and ω meson-nucleon coupling constants, only. Resulting NN phase shifts are in a good agreement with both, the empirical data, and the entirely phenomenological Bonn OBEP model fit. While the quality of our description, evaluated as a ratio of our results to the Bonn OBEP model χ2 ones is about 1.2, other existing (semi)microscopic results gave qualitative results only.

Anisotropic inflation with derivative couplings

NASA Astrophysics Data System (ADS)

Holland, Jonathan; Kanno, Sugumi; Zavala, Ivonne

2018-05-01

We study anisotropic power-law inflationary solutions when the inflaton and its derivative couple to a vector field. This type of coupling is motivated by D-brane inflationary models, in which the inflaton, and a vector field living on the D-brane, couple disformally (derivatively). We start by studying a phenomenological model where we show the existence of anisotropic solutions and demonstrate their stability via a dynamical system analysis. Compared to the case without a derivative coupling, the anisotropy is reduced and thus can be made consistent with current limits, while the value of the slow-roll parameter remains almost unchanged. We also discuss solutions for more general cases, including D-brane-like couplings.

Fast support vector data descriptions for novelty detection.

PubMed

Liu, Yi-Hung; Liu, Yan-Chen; Chen, Yen-Jen

2010-08-01

Support vector data description (SVDD) has become a very attractive kernel method due to its good results in many novelty detection problems. However, the decision function of SVDD is expressed in terms of the kernel expansion, which results in a run-time complexity linear in the number of support vectors. For applications where fast real-time response is needed, how to speed up the decision function is crucial. This paper aims at dealing with the issue of reducing the testing time complexity of SVDD. A method called fast SVDD (F-SVDD) is proposed. Unlike the traditional methods which all try to compress a kernel expansion into one with fewer terms, the proposed F-SVDD directly finds the preimage of a feature vector, and then uses a simple relationship between this feature vector and the SVDD sphere center to re-express the center with a single vector. The decision function of F-SVDD contains only one kernel term, and thus the decision boundary of F-SVDD is only spherical in the original space. Hence, the run-time complexity of the F-SVDD decision function is no longer linear in the support vectors, but is a constant, no matter how large the training set size is. In this paper, we also propose a novel direct preimage-finding method, which is noniterative and involves no free parameters. The unique preimage can be obtained in real time by the proposed direct method without taking trial-and-error. For demonstration, several real-world data sets and a large-scale data set, the extended MIT face data set, are used in experiments. In addition, a practical industry example regarding liquid crystal display micro-defect inspection is also used to compare the applicability of SVDD and our proposed F-SVDD when faced with mass data input. The results are very encouraging.

Co-occurrence and distribution of East (L1014S) and West (L1014F) African knock-down resistance in Anopheles gambiae sensu lato population of Tanzania

PubMed Central

Kabula, Bilali; Kisinza, William; Tungu, Patrick; Ndege, Chacha; Batengana, Benard; Kollo, Douglas; Malima, Robert; Kafuko, Jessica; Mohamed, Mahdi; Magesa, Stephen

2014-01-01

Objective Insecticide resistance molecular markers can provide sensitive indicators of resistance development in Anopheles vector populations. Assaying these makers is of paramount importance in the resistance monitoring programme. We investigated the presence and distribution of knock-down resistance (kdr) mutations in Anopheles gambiae s.l. in Tanzania. Methods Indoor-resting Anopheles mosquitoes were collected from 10 sites and tested for insecticide resistance using the standard WHO protocol. Polymerase chain reaction-based molecular diagnostics were used to genotype mosquitoes and detect kdr mutations. Results The An. gambiae tested were resistance to lambdacyhalothrin in Muheza, Arumeru and Muleba. Out of 350 An. gambiae s.l. genotyped, 35% were An. gambiae s.s. and 65% An. arabiensis. L1014S and L1014F mutations were detected in both An. gambiae s.s. and An. arabiensis. L1014S point mutation was found at the allelic frequency of 4–33%, while L1014F was at the allelic frequency 6–41%. The L1014S mutation was much associated with An. gambiae s.s. (χ2 = 23.41; P < 0.0001) and L1014F associated with An. arabiensis (χ2 = 11.21; P = 0.0008). The occurrence of the L1014S allele was significantly associated with lambdacyhalothrin resistance mosquitoes (Fisher exact P < 0.001). Conclusion The observed co-occurrence of L1014S and L1014F mutations coupled with reports of insecticide resistance in the country suggest that pyrethroid resistance is becoming a widespread phenomenon among our malaria vector populations. The presence of L1014F mutation in this East African mosquito population indicates the spreading of this gene across Africa. The potential operational implications of these findings on malaria control need further exploration. Objectif Les marqueurs moléculaires de la résistance aux insecticides peuvent fournir des indicateurs sensibles du développement de la résistance dans les populations de vecteurs Anopheles. Le test de ces indicateurs est d'une importance énorme dans le programme de surveillance de la résistance. Nous avons étudié la présence et la répartition des mutations de résistance knockdown (kdr) chez Anopheles gambiae s.l. en Tanzanie. Méthodes Des anophèles d'intérieur, au repos ont été collectées dans 10 sites et testées pour la résistance aux insecticides en utilisant le protocole standard de l'OMS. Les diagnostics moléculaires basés sur la PCR ont été utilisés pour le génotypage des moustiques et la détection des génotypes kdr. Résultats Les An. gambiae testées étaient résistantes à la lambdacyhalothrine à Muheza, Arumeru et Muleba. Sur 350 An. gambiae s.l. génotypées, 35% étaient An. gambiae s.s. et 65% étaient An. arabiensis. Les mutations L1014S et L1014F ont été détectées à la fois chez An. gambiae s.s. et An. arabiensis. La mutation ponctuelle L1014S a été trouvée à la fréquence allélique de 4 à 33%, tandis que L1014F était à la fréquence allélique de 6 à 14%. La mutation L1014S a été fortement associée à An. gambiae s.s. (Chi carré = 23,41; P<0,0001) et L1014F était associée à An. arabiensis (chi carré = 11,21; P = 0,0008). L'allèle L1014S était significativement associé aux moustiques résistants à la lambdacyhalothrine (Fisher P exact <0,001). Conclusion La cooccurrence des mutations L1014S et L1014F couplées à des rapports sur la résistance aux insecticides suggèrent que la résistance aux pyréthrinoïdes est en train de devenir un phénomène répandu dans les populations de vecteurs du paludisme en Tanzanie. La présence de la mutation L1014F dans cette population de moustiques en Afrique de l'Est indique la propagation de ce gène à travers l'Afrique. L'investigation des implications opérationnelles potentielles de ces résultats sur le contrôle du paludisme devraient être approfondie. Objetivo Los marcadores moleculares de resistencia a insecticidas pueden ser indicadores sensibles del desarrollo de resistencias en las poblaciones de los vectores Anopheles. Evaluar dichos marcadores es crucial para los programas de monitorización de resistencias. Hemos investigado la presencia y la distribución de las mutaciones de resistencia knockdown (kdr) en Anopheles gambiae s.l. en Tanzania. Métodos Se recolectaron mosquitos Anopheles intradomiciliarios de 10 lugares diferentes y se evaluaron en busca de resistencia a insecticidas utilizando el protocolo estándar de la OMS. Mediante un diagnóstico molecular basado en la PCR se genotiparon los mosquitos y se detectaron los genotipos kdr. Resultados Los An. gambiae evaluados eran resistentes a lambdacialotrina en Muheza, Arumeru y Muleba. De 350 An. gambiae s.l. genotipados, 35% eran An. gambiae s.s. y 65% eran An. arabiensis. Se detectaron mutaciones L1014S y L1014F tanto en An. gambiae s.s. como en An. arabiensis. La mutación puntual L1014S se encontró con una frecuencia alélica de 4-33%, mientras que L1014F tenía una frecuencia alélica de 6-14%. La mutación L1014S estaba ampliamente asociada a An. gambiae s.s. (Chi-Cuadrado = 23.41; P < 0.0001) y la L1014F estaba asociada con An. arabiensis (Chi-Square = 11.21; P = 0.0008). El alelo L1014S estaba significativamente asociado con mosquitos resistentes a la lambdacialotrina (P < 0.001). Conclusión La simultaneidad de mutaciones de L1014S y L1014F junto con informes de resistencia a los insecticidas sugiere que la resistencia a piretroides se está convirtiendo en un fenómeno común entre las poblaciones del vector de la malaria en Tanzania. La presencia de la mutación L1014F en estas poblaciones del Este de África indican la diseminación del gen a lo largo del continente africano. Determinar las implicaciones potenciales a nivel operativo de estos hallazgos sobre el control de la malaria requiere de más estudios. PMID:24386946

Molecular dynamics simulation of the polymer electrolyte poly(ethylene oxide)/LiClO(4). II. Dynamical properties.

PubMed

Siqueira, Leonardo J A; Ribeiro, Mauro C C

2006-12-07

The dynamical properties of the polymer electrolyte poly(ethylene oxide) (PEO)LiClO(4) have been investigated by molecular dynamics simulations. The effect of changing salt concentration and temperature was evaluated on several time correlation functions. Ionic displacements projected on different directions reveal anisotropy in short-time (rattling) and long-time (diffusive) dynamics of Li(+) cations. It is shown that ionic mobility is coupled to the segmental motion of the polymeric chain. Structural relaxation is probed by the intermediate scattering function F(k,t) at several wave vectors. Good agreement was found between calculated and experimental F(k,t) for pure PEO. A remarkable slowing down of polymer relaxation is observed upon addition of the salt. The ionic conductivity estimated by the Nernst-Einstein equation is approximately ten times higher than the actual conductivity calculated by the time correlation function of charge current.

Effects of hormonal contraceptive use on HIV acquisition and transmission among HIV-discordant couples.

PubMed

Lutalo, Tom; Musoke, Richard; Kong, Xiangrong; Makumbi, Fred; Serwadda, David; Nalugoda, Fred; Kigozi, Godfrey; Sewankambo, Nelson; Sekasanvu, Joseph; Wawer, Maria; Gray, Ronald

2013-10-01

The risk of HIV associated with hormonal contraceptives is controversial. We assessed hormonal contraceptive use and HIV incidence in HIV-discordant couples in Rakai, Uganda. HIV-discordant couples were retrospectively identified from a cohort between 1999 and 2009. Hormonal contraception included oral contraception, depomedroxyprogesterone acetate (DMPA), and implants (Norplant). Poisson regression estimated adjusted incidence rate ratios (adjIRRs) associated with hormonal contraceptive methods. A case-control subanalysis estimated odds ratios (ORs) of HIV associated with hormonal contraceptive, adjusted for viral load and age. We identified 190 male HIV-positive/female HIV-negative (M+F-) and 159 male HIV- negative/female HIV-positive (M-F+) couples not using antiretroviral therapy or condoms. Female HIV incidence was 5.8/100 person-years (py) among nonhormonal contraceptive users, 12.0/100 py among oral contraceptive users [adjIRR 2.65, 95% confidence interval (CI) 0.82-8.60], 4.5 among Norplant users (adjIRR: 0.89, 95% CI 0.11-7.10), and 7.5/100 py among DMPA users (adjIRR 1.42, 95% CI 0.60-3.36). Male HIV incidence was 7.4/100 py during nonhormonal contraceptive use, 16.5/100 py during female oral contraceptive use (adjIRR 2.52, 95% CI 0.49-12.95), and 4.9/100 py with DMPA use (adjIRR 0.57, 95% CI 0.19-1.70). The number of female seroconverters was three among oral contraceptive users, one among Norplant users, and seven among DMPA users. Male seroconverters were two during female oral contraceptive use, none with Norplant use, and three with DMPA use. In a nested case-control analysis after adjustment for HIV viral load, the adjOR associated with oral contraceptive use was 1.59 (95% CI 0.32-97.85) for M+F- and 2.11 (95% CI 0.18-25.26) for M-F+ couples. For DMPA use, the adjOR was 1.44 (95% CI 0.46-4.51) for M+F- and 1.40 (95% CI 0.30-6.49) for M-F+ couples. We did not observe significant risk of HIV acquisition or transmission with oral contraceptives or DMPA use in HIV discordant couples, but several point estimates were above 1.0 and statistical power was limited.

Dynamics of the Pin Pallet Runaway Escapement

DTIC Science & Technology

1978-06-01

for Continued Work 29 References 32 I Appendixes A Kinematics of Coupled Motion 34 B Differential Equation of Coupled Motion 38 f C Moment Arms 42 D...Expressions for these quantities are derived in appendix D. The differential equations for the free motion of the pallet and the escape-wheel are...Coupled Motion (location 100) To solve the differential equation of coupled motion (see equation .B (-10) of appendix B)- the main program calls on

Fermi wave vector for the partially spin-polarized composite-fermion Fermi sea

NASA Astrophysics Data System (ADS)

Balram, Ajit C.; Jain, J. K.

2017-12-01

The fully spin-polarized composite-fermion (CF) Fermi sea at the half-filled lowest Landau level has a Fermi wave vector kF*=√{4 π ρe } , where ρe is the density of electrons or composite fermions, supporting the notion that the interaction between composite fermions can be treated perturbatively. Away from ν =1 /2 , the area is seen to be consistent with kF*=√{4 π ρe } for ν <1 /2 but kF*=√{4 π ρh } for ν >1 /2 , where ρh is the density of holes in the lowest Landau level. This result is consistent with particle-hole symmetry in the lowest Landau level. We investigate in this article the Fermi wave vector of the spin-singlet CF Fermi sea (CFFS) at ν =1 /2 , for which particle-hole symmetry is not a consideration. Using the microscopic CF theory, we find that for the spin-singlet CFFS the Fermi wave vectors for up- and down-spin CFFSs at ν =1 /2 are consistent with kF*↑,↓=√{4 π ρe↑,↓ } , where ρe↑=ρe↓=ρe/2 , which implies that the residual interactions between composite fermions do not cause a nonperturbative correction for spin-singlet CFFS either. Our results suggest the natural conjecture that for arbitrary spin polarization the CF Fermi wave vectors are given by kF*↑=√{4 π ρe↑ } and kF*↓=√{4 π ρe↓ } .

Study of. nu. d r arrow. mu. sup minus pp sub s and. nu. d r arrow. mu. sup minus. Delta. sup ++ (1232) n sub s using the BNL 7-foot deuterium-filled bubble chamber

DOE Office of Scientific and Technical Information (OSTI.GOV)

Kitagaki, T.; Yuta, H.; Tanaka, S.

1990-09-01

The weak nucleon axial-vector ({ital F}{sub {ital A}}) and vector ({ital F}{sub {ital V}}) form factors are determined from the momentum-transfer-squared ({ital Q}{sup 2}) distributions using 2538 {mu}{sup {minus}} {ital p} and 1384 {mu}{sup {minus}}{Delta}{sup ++} events. The data were obtained from 1 800 000 pictures taken in the BNL 7-foot deuterium-filled bubble chamber exposed to a wide-band neutrino beam with a mean energy {ital E}{sub {nu}}=1.6 GeV. In the framework of the conventional {ital V}{minus}{ital A} theory with standard assumptions, the value obtained from the {mu}{sup {minus}}{ital p} events for the axial-vector mass {ital M}{sub {ital A}} in themore » pure dipole parameterization is 1.070{sub {minus}0.045}{sup +0.040} GeV and from the {mu}{sup {minus}}{Delta}{sup ++} events is 1.28{sub {minus}0.10}{sup +0.08} GeV. These results are in good agreement with an earlier measurement from this experiment and other recent results. The reaction mechanisms for both processes are compared and found to be very similar. A two-parameter fit for the quasielastic reaction, using dipole forms for {ital F}{sub {ital V}} and {ital F}{sub {ital A}}, yields {ital M}{sub {ital A}}=0.97{sub {minus}0.11}{sup +0.14} GeV and {ital M}{sub {ital V}}=0.89{sub {minus}0.07}{sup +0.04} GeV, which is in good agreement with the conserved-vector-current value of {ital M}{sub {ital V}}=0.84 GeV. Possible deviations from the standard assumptions are also discussed.« less

Index formulas for higher order Loewner vector fields

NASA Astrophysics Data System (ADS)

Broad, Steven

Let ∂ be the Cauchy-Riemann operator and f be a C real-valued function in a neighborhood of 0 in R in which ∂z¯nf≠0 for all z≠0. In such cases, ∂z¯nf is known as a Loewner vector field due to its connection with Loewner's conjecture that the index of such a vector field is bounded above by n. The n=2 case of Loewner's conjecture implies Carathéodory's conjecture that any C-immersion of S into R must have at least two umbilics. Recent work of F. Xavier produced a formula for computing the index of Loewner vector fields when n=2 using data about the Hessian of f. In this paper, we extend this result and establish an index formula for ∂z¯nf for all n⩾2. Structurally, our index formula provides a defect term, which contains geometric data extracted from Hessian-like objects associated with higher order derivatives of f.

A Flow Visualization Study of Laminar/Turbulent Transition in a Curved Channel

DTIC Science & Technology

1987-03-01

convected down- stream, to deform as shown in Figure 16. One possible arrangement of velocity vectors in the radial plane which could cause such a...Re 2231 KODAK RECORDING FEILD ASA 1,000 (f2.8, B) 10 ....... .... . . . . . . .. Figure C.33 IV-4 2100-2330 15 FEB 1987 8.0 % FLOW (rotameter) MEAN

Etching Enhancement Followed by Nitridation on Low-k SiOCH Film in Ar/C5F10O Plasma

NASA Astrophysics Data System (ADS)

Miyawaki, Yudai; Shibata, Emi; Kondo, Yusuke; Takeda, Keigo; Kondo, Hiroki; Ishikawa, Kenji; Okamoto, Hidekazu; Sekine, Makoto; Hori, Masaru

2013-02-01

The etching rates of low-dielectric-constant (low-k), porous SiOCH (p-SiOCH) films were increased by nitrogen-added Ar/C5F10O plasma etching in dual-frequency (60 MHz/2 MHz)-excited parallel plate capacitively coupled plasma. Previously, perfluoropropyl vinyl ether [C5F10O] provided a very high density of CF3+ ions [Nagai et al.: Jpn. J. Appl. Phys. 45 (2006) 7100]. Surface nitridation on the p-SiOCH surface exposed to Ar/N2 plasma led to the etching of larger amounts of p-SiOCH in Ar/C5F10O plasma, which depended on the formation of bonds such as =C(sp2)=N(sp2)- and -C(sp)≡N(sp).

Integrated optic vector-matrix multiplier

DOEpatents

Watts, Michael R [Albuquerque, NM

2011-09-27

A vector-matrix multiplier is disclosed which uses N different wavelengths of light that are modulated with amplitudes representing elements of an N.times.1 vector and combined to form an input wavelength-division multiplexed (WDM) light stream. The input WDM light stream is split into N streamlets from which each wavelength of the light is individually coupled out and modulated for a second time using an input signal representing elements of an M.times.N matrix, and is then coupled into an output waveguide for each streamlet to form an output WDM light stream which is detected to generate a product of the vector and matrix. The vector-matrix multiplier can be formed as an integrated optical circuit using either waveguide amplitude modulators or ring resonator amplitude modulators.

Seasonal Abundance and Natural Inoculativity of Insect Vectors of Xylella fastidiosa in Oklahoma Tree Nurseries and Vineyards.

PubMed

Overall, Lisa M; Rebek, Eric J

2015-12-01

Xylella fastidiosa is the causative agent of diseases of perennial plants including peach, plum, elm, oak, pecan, and grape. This bacterial pathogen is transmitted by xylem-feeding insects. In recent years, Pierce's disease of grape has been detected in 10 counties in central and northeastern Oklahoma, prompting further investigation of the disease epidemiology in this state. We surveyed vineyards and tree nurseries in Oklahoma for potential insect vectors to determine species composition, infectivity, and natural inoculativity of commonly captured insect vectors. Yellow sticky cards were used to sample insect fauna at each location. Insects were removed from sticky cards and screened for X. fastidiosa using immunocapture-PCR to determine their infectivity. A second objective was to test the natural inoculativity of insect vectors that are found in vineyards. Graphocephala versuta (Say), Graphocephala coccinea (Forster), Paraulacizes irrorata (F.), Oncometopia orbona (F.), Cuerna costalis (F.), and Entylia carinata Germar were collected from vineyards and taken back to the lab to determine their natural inoculativity. Immunocapture-PCR was used to test plant and insect samples for presence of X. fastidiosa. The three most frequently captured species from vineyards and tree nurseries were G. versuta, Clastoptera xanthocephala Germar, and O. orbona. Of those insects screened for X. fastidiosa, 2.4% tested positive for the bacterium. Field-collected G. versuta were inoculative to both ragweed and alfalfa. Following a 7-d inoculation access period, a higher percentage of alfalfa became infected than ragweed. Results from this study provide insight into the epidemiology of X. fastidiosa in Oklahoma. © The Authors 2015. Published by Oxford University Press on behalf of Entomological Society of America. All rights reserved. For Permissions, please email: journals.permissions@oup.com.

Prevention of Breast Cancer Cell Transformation by Blockade of the AP-1 Transcription Factor

DTIC Science & Technology

1998-10-01

184 M . Stampfer Immortal HMECs: 184B5 M . Stampfer Immortal, anchorage dependent MCF10A A. Russo Breast Cancer cell lines: MCF7 WT K. Cowan Cancer cells...34 []-DOX [] +DOX Sr-- 2.0 T -,ri-i-rTI•r-1.1.1 H S1ɘ.5 -0.5 0.0- - -- --" "r 0.0 " - " -- m #1#2 #31~ #1#2 #3 , •#1 #2~ , #1 #2 Vector TAM-67 Vector TAM...6F 0 2 4 6 8 02460.0 ... 1.50. ( ’ M 2’ #3 65 ’ 9 91234567 1234567 1.25 L. TAM-67 TAM-67 o-2.0-(.~1.00. 0.75. ~ 1.5’ d0.50 1.I1.07 0.25 10. .) 0 .0 1

Reverberant acoustic energy in auditoria that comprise systems of coupled rooms

NASA Astrophysics Data System (ADS)

Summers, Jason Erik

A frequency-dependent model for levels and decay rates of reverberant energy in systems of coupled rooms is developed and compared with measurements conducted in a 1:10 scale model and in Bass Hall, Fort Worth, TX. Schroeder frequencies of subrooms, fSch, characteristic size of coupling apertures, a, relative to wavelength lambda, and characteristic size of room surfaces, l, relative to lambda define the frequency regions. At high frequencies [HF (f >> f Sch, a >> lambda, l >> lambda)], this work improves upon prior statistical-acoustics (SA) coupled-ODE models by incorporating geometrical-acoustics (GA) corrections for the model of decay within subrooms and the model of energy transfer between subrooms. Previous researchers developed prediction algorithms based on computational GA. Comparisons of predictions derived from beam-axis tracing with scale-model measurements indicate that systematic errors for coupled rooms result from earlier tail-correction procedures that assume constant quadratic growth of reflection density. A new algorithm is developed that uses ray tracing rather than tail correction in the late part and is shown to correct this error. At midfrequencies [MF (f >> f Sch, a ˜ lambda)], HF models are modified to account for wave effects at coupling apertures by including analytically or heuristically derived power transmission coefficients tau. This work improves upon prior SA models of this type by developing more accurate estimates of random-incidence tau. While the accuracy of the MF models is difficult to verify, scale-model measurements evidence the expected behavior. The Biot-Tolstoy-Medwin-Svensson (BTMS) time-domain edge-diffraction model is newly adapted to study transmission through apertures. Multiple-order BTMS scattering is theoretically and experimentally shown to be inaccurate due to the neglect of slope diffraction. At low frequencies (f ˜ f Sch), scale-model measurements have been qualitatively explained by application of previously developed perturbation models. Measurements newly confirm that coupling strength between three-dimensional rooms is related to unperturbed pressure distribution on the coupling surface. In Bass Hall, measurements are conducted to determine the acoustical effects of the coupled stage house on stage and in the audience area. The high-frequency predictions of statistical- and geometrical-acoustics models agree well with measured results. Predictions of the transmission coefficients of the coupling apertures agree, at least qualitatively, with the observed behavior.

Relativistic stars in vector-tensor theories

NASA Astrophysics Data System (ADS)

Kase, Ryotaro; Minamitsuji, Masato; Tsujikawa, Shinji

2018-04-01

We study relativistic star solutions in second-order generalized Proca theories characterized by a U (1 )-breaking vector field with derivative couplings. In the models with cubic and quartic derivative coupling, the mass and radius of stars become larger than those in general relativity for negative derivative coupling constants. This phenomenon is mostly attributed to the increase of star radius induced by a slower decrease of the matter pressure compared to general relativity. There is a tendency that the relativistic star with a smaller mass is not gravitationally bound for a low central density and hence is dynamically unstable, but that with a larger mass is gravitationally bound. On the other hand, we show that the intrinsic vector-mode couplings give rise to general relativistic solutions with a trivial field profile, so the mass and radius are not modified from those in general relativity.

Vector mode conversion based on tilted fiber Bragg grating in ring-core fibers

NASA Astrophysics Data System (ADS)

Mi, Yuean; Ren, Guobin; Gao, Yixiao; Li, Haisu; Zhu, Bofeng; Liu, Yu

2018-03-01

We propose a vector mode conversion approach based on tilted fiber Bragg grating (TFBG) written in ring-core fiber with effective separation of eigenmodes. The mode coupling properties of TFBG are numerically investigated. It is shown that under the constraint of phase matching, the conversion of high-order vector modes could be achieved at specific wavelengths. Moreover, the polarization of incident light and tilt angle of TFBG play critical roles in mode coupling process. The proposed TFBG provides an efficient method to realize high-order vector mode conversion, and it shows great potential for fibers based OAM beam generation and fiber lasers with vortex beams output.

Analysis of expressed sequence tags for Frankliniella occidentalis, the western flower thrips.

PubMed

Rotenberg, D; Whitfield, A E

2010-08-01

Thrips are members of the insect order Thysanoptera and Frankliniella occidentalis (the western flower thrips) is the most economically important pest within this order. F. occidentalis is both a direct pest of crops and an efficient vector of plant viruses, including Tomato spotted wilt virus (TSWV). Despite the world-wide importance of thrips in agriculture, there is little knowledge of the F. occidentalis genome or gene functions at this time. A normalized cDNA library was constructed from first instar thrips and 13 839 expressed sequence tags (ESTs) were obtained. Our EST data assembled into 894 contigs and 11 806 singletons (12 700 nonredundant sequences). We found that 31% of these sequences had significant similarity (E< or = 10(-10)) to protein sequences in the National Center for Biotechnology Information nonredundant (nr) protein database, and 25% were functionally annotated using Blast 2GO. We identified 74 sequences with putative homology to proteins associated with insect innate immunity. Sixteen sequences had significant similarity to proteins associated with small RNA-mediated gene silencing pathways (RNA interference; RNAi), including the antiviral pathway (short interfering RNA-mediated pathway). Our EST collection provides new sequence resources for characterizing gene functions in F. occidentalis and other thrips species with regards to vital biological processes, studying the mechanism of interactions with the viruses harboured and transmitted by the vector, and identifying new insect gene-centred targets for plant disease and insect control.

Improved dual AAV vectors with reduced expression of truncated proteins are safe and effective in the retina of a mouse model of Stargardt disease.

PubMed

Trapani, Ivana; Toriello, Elisabetta; de Simone, Sonia; Colella, Pasqualina; Iodice, Carolina; Polishchuk, Elena V; Sommella, Andrea; Colecchi, Linda; Rossi, Settimio; Simonelli, Francesca; Giunti, Massimo; Bacci, Maria L; Polishchuk, Roman S; Auricchio, Alberto

2015-12-01

Stargardt disease (STGD1) due to mutations in the large ABCA4 gene is the most common inherited macular degeneration in humans. We have shown that dual adeno-associated viral (AAV) vectors effectively transfer ABCA4 to the retina of Abca4-/- mice. However, they express both lower levels of transgene compared with a single AAV and truncated proteins. To increase productive dual AAV concatemerization, which would overcome these limitations, we have explored the use of either various regions of homology or heterologous inverted terminal repeats (ITR). In addition, we tested the ability of various degradation signals to decrease the expression of truncated proteins. We found the highest levels of transgene expression using regions of homology based on either alkaline phosphatase or the F1 phage (AK). The use of heterologous ITR does not decrease the levels of truncated proteins relative to full-length ABCA4 and impairs AAV vector production. Conversely, the inclusion of the CL1 degradation signal results in the selective degradation of truncated proteins from the 5'-half without affecting full-length protein production. Therefore, we developed dual AAV hybrid ABCA4 vectors including homologous ITR2, the photoreceptor-specific G protein-coupled receptor kinase 1 promoter, the AK region of homology and the CL1 degradation signal. We show that upon subretinal administration these vectors are both safe in pigs and effective in Abca4-/- mice. Our data support the use of improved dual AAV vectors for gene therapy of STGD1. © The Author 2015. Published by Oxford University Press.

Generation of helical magnetic field in a viable scenario of inflationary magnetogenesis

NASA Astrophysics Data System (ADS)

Sharma, Ramkishor; Subramanian, Kandaswamy; Seshadri, T. R.

2018-04-01

We study the generation of helical magnetic fields in a model of inflationary magnetogenesis which is free from the strong coupling and backreaction problems. To generate helical magnetic fields, we add an f2F˜μ νFμ ν term to the Lagrangian of the Ratra model. The strong coupling and backreaction problems are avoided if we take a particular behavior of coupling function f , in which f increases during inflation and decreases postinflation to reheating. The generated magnetic field is fully helical and has a blue spectrum, d ρB/d ln k ∝k4. This spectrum is obtained when coupling function f ∝a2 during inflation. The scale of reheating in our model has to be lower than 4000 GeV to avoid backreaction postinflation. The generated magnetic field spectrum satisfies the γ -ray bound for all the possible scales of reheating. The comoving magnetic field strength and its correlation length are ˜4 ×10-11 G and 70 kpc respectively, if reheating takes place at 100 GeV. For reheating at the QCD scales of 150 MeV, the field strength increases to ˜ nano gauss, with coherence scale of 0.6 Mpc.

Quantum Monte Carlo studies of superfluid Fermi gases

DOE Office of Scientific and Technical Information (OSTI.GOV)

Chang, S.Y.; Pandharipande, V.R.; Carlson, J.

2004-10-01

We report results of quantum Monte Carlo calculations of the ground state of dilute Fermi gases with attractive short-range two-body interactions. The strength of the interaction is varied to study different pairing regimes which are characterized by the product of the s-wave scattering length and the Fermi wave vector, ak{sub F}. We report results for the ground-state energy, the pairing gap {delta}, and the quasiparticle spectrum. In the weak-coupling regime, 1/ak{sub F}<-1, we obtain Bardeen-Cooper-Schrieffer (BCS) superfluid and the energy gap {delta} is much smaller than the Fermi gas energy E{sub FG}. When a>0, the interaction is strong enough tomore » form bound molecules with energy E{sub mol}. For 1/ak{sub F} > or approx. 0.5, we find that weakly interacting composite bosons are formed in the superfluid gas with {delta} and gas energy per particle approaching E{sub mol}/2. In this region, we seem to have Bose-Einstein condensation (BEC) of molecules. The behavior of the energy and the gap in the BCS-to-BEC transition region, -0.5<1/ak{sub F}<0.5, is discussed.« less

Model independent new physics analysis in Λ _b→ Λ μ ^+μ ^- decay

NASA Astrophysics Data System (ADS)

Das, Diganta

2018-03-01

We study the rare Λ _b→ Λ μ ^+μ ^- decay in the Standard Model and beyond. Beyond the Standard Model we include new vector and axial-vector operators, scalar and pseudo-scalar operators, and tensor operators in the effective Hamiltonian. Working in the helicity basis and using appropriate parametrization of the Λ _b → Λ hadronic matrix elements, we give expressions of hadronic and leptonic helicity amplitudes and derive expression of double differential branching ratio with respect to dilepton invariant mass squared and cosine of lepton angle. Appropriately integrating the differential branching ratio over the lepton angle, we obtain the longitudinal polarization fraction and the leptonic forward-backward asymmetry and sequentially study the observables in the presence of the new couplings. To analyze the implications of the new vector and axial-vector couplings, we follow the current global fits to b→ sμ ^+μ ^- data. While the impacts of scalar couplings can be significant, exclusive \\bar{B}→ X_sμ ^+μ ^- data imply stringent constraints on the tensor couplings and hence the effects on Λ _b→ Λ μ ^+μ ^- are negligible.

A static investigation of the thrust vectoring system of the F/A-18 high-alpha research vehicle

NASA Technical Reports Server (NTRS)

Mason, Mary L.; Capone, Francis J.; Asbury, Scott C.

1992-01-01

A static (wind-off) test was conducted in the static test facility of the Langley 16-foot Transonic Tunnel to evaluate the vectoring capability and isolated nozzle performance of the proposed thrust vectoring system of the F/A-18 high alpha research vehicle (HARV). The thrust vectoring system consisted of three asymmetrically spaced vanes installed externally on a single test nozzle. Two nozzle configurations were tested: A maximum afterburner-power nozzle and a military-power nozzle. Vane size and vane actuation geometry were investigated, and an extensive matrix of vane deflection angles was tested. The nozzle pressure ratios ranged from two to six. The results indicate that the three vane system can successfully generate multiaxis (pitch and yaw) thrust vectoring. However, large resultant vector angles incurred large thrust losses. Resultant vector angles were always lower than the vane deflection angles. The maximum thrust vectoring angles achieved for the military-power nozzle were larger than the angles achieved for the maximum afterburner-power nozzle.

τ → f1(1285) π-ν_{τ} decay in the extended Nambu-Jona-Lasinio model

NASA Astrophysics Data System (ADS)

Volkov, M. K.; Pivovarov, A. A.; Osipov, A. A.

2018-04-01

Within the framework of the extended Nambu-Jona-Lasinio model, we calculate the matrix element of the τ → f1(1285) π- ν_{τ} decay, obtain the invariant mass distribution of the f1π-system and estimate the branching ratio Br(τ → f1 π-ν_{τ}) = 4.0× 10^{-4}. The two types of contributions are considered: the contact interaction, and the axial-vector IG(J^{PC})=1-(1^{++}) resonance exchange. The latter includes the ground a1(1260) state, and its first radially excited state, a1(1640). The corrections caused by the π-a1 transitions are taken into account. Our estimate is in a good agreement with the latest empirical result Br(τ → f1 π- ν_{τ})=(3.9± 0.5)× 10^{-4}. The distribution function obtained for the decay τ → f1(1285) π- ν_{τ} shows a clear signal of a1(1640) resonance which should be compared with future experimental data including our estimate of the decay width Γ (a1(1640) → f1 π)=14.1 MeV.

Ab initio study of dynamical E × e Jahn-Teller and spin-orbit coupling effects in the transition-metal trifluorides TiF3, CrF3, and NiF3

NASA Astrophysics Data System (ADS)

Mondal, Padmabati; Opalka, Daniel; Poluyanov, Leonid V.; Domcke, Wolfgang

2012-02-01

Multiconfiguration ab initio methods have been employed to study the effects of Jahn-Teller (JT) and spin-orbit (SO) coupling in the transition-metal trifluorides TiF3, CrF3, and NiF3, which possess spatially doubly degenerate excited states (ME) of even spin multiplicities (M = 2 or 4). The ground states of TiF3, CrF3, and NiF3 are nondegenerate and exhibit minima of D3h symmetry. Potential-energy surfaces of spatially degenerate excited states have been calculated using the state-averaged complete-active-space self-consistent-field method. SO coupling is described by the matrix elements of the Breit-Pauli operator. Linear and higher order JT coupling constants for the JT-active bending and stretching modes as well as SO-coupling constants have been determined. Vibronic spectra of JT-active excited electronic states have been calculated, using JT Hamiltonians for trigonal systems with inclusion of SO coupling. The effect of higher order (up to sixth order) JT couplings on the vibronic spectra has been investigated for selected electronic states and vibrational modes with particularly strong JT couplings. While the weak SO couplings in TiF3 and CrF3 are almost completely quenched by the strong JT couplings, the stronger SO coupling in NiF3 is only partially quenched by JT coupling.

Ultra-Reliable Digital Avionics (URDA) processor

NASA Astrophysics Data System (ADS)

Branstetter, Reagan; Ruszczyk, William; Miville, Frank

1994-10-01

Texas Instruments Incorporated (TI) developed the URDA processor design under contract with the U.S. Air Force Wright Laboratory and the U.S. Army Night Vision and Electro-Sensors Directorate. TI's approach couples advanced packaging solutions with advanced integrated circuit (IC) technology to provide a high-performance (200 MIPS/800 MFLOPS) modular avionics processor module for a wide range of avionics applications. TI's processor design integrates two Ada-programmable, URDA basic processor modules (BPM's) with a JIAWG-compatible PiBus and TMBus on a single F-22 common integrated processor-compatible form-factor SEM-E avionics card. A separate, high-speed (25-MWord/second 32-bit word) input/output bus is provided for sensor data. Each BPM provides a peak throughput of 100 MIPS scalar concurrent with 400-MFLOPS vector processing in a removable multichip module (MCM) mounted to a liquid-flowthrough (LFT) core and interfacing to a processor interface module printed wiring board (PWB). Commercial RISC technology coupled with TI's advanced bipolar complementary metal oxide semiconductor (BiCMOS) application specific integrated circuit (ASIC) and silicon-on-silicon packaging technologies are used to achieve the high performance in a miniaturized package. A Mips R4000-family reduced instruction set computer (RISC) processor and a TI 100-MHz BiCMOS vector coprocessor (VCP) ASIC provide, respectively, the 100 MIPS of a scalar processor throughput and 400 MFLOPS of vector processing throughput for each BPM. The TI Aladdim ASIC chipset was developed on the TI Aladdin Program under contract with the U.S. Army Communications and Electronics Command and was sponsored by the Advanced Research Projects Agency with technical direction from the U.S. Army Night Vision and Electro-Sensors Directorate.

Coupling of Carbon Nanotubes to Metallic Contacts

NASA Technical Reports Server (NTRS)

Anantram, M. P.; Datta, S.; Xue, Yong-Xiang; Govindan, T. R. (Technical Monitor)

1999-01-01

The modeling of carbon nanotube-metal contacts is important from both basic and applied view points. For many applications, it is important to design contacts such that the transmission is dictated by intrinsic properties of the nanotube rather than by details of the contact. In this paper, we calculate the electron transmission probability from a nanotube to a free electron metal, which is side-contacted. If the metal-nanotube interface is sufficiently ordered, we find that k-vector conservation plays an important role in determining the coupling, with the physics depending on the area of contact, tube diameter, and chirality. The main results of this paper are: (1) conductance scales with contact length, a phenomena that has been observed in experiments and (2) in the case of uniform coupling between metal and nanotube, the threshold value of the metal Fermi wave vector (below which coupling is insignificant) depends on chirality. Disorder and small phase coherence length relax the need for k-vector conservation, thereby making the coupling stronger.

Applicability of initial optimal maternal and fetal electrocardiogram combination vectors to subsequent recordings

NASA Astrophysics Data System (ADS)

Yan, Hua-Wen; Huang, Xiao-Lin; Zhao, Ying; Si, Jun-Feng; Liu, Tie-Bing; Liu, Hong-Xing

2014-11-01

A series of experiments are conducted to confirm whether the vectors calculated for an early section of a continuous non-invasive fetal electrocardiogram (fECG) recording can be directly applied to subsequent sections in order to reduce the computation required for real-time monitoring. Our results suggest that it is generally feasible to apply the initial optimal maternal and fetal ECG combination vectors to extract the fECG and maternal ECG in subsequent recorded sections.

Magnetic Rotational Spectroscopy with Nanorods to Probe Time-Dependent Rheology of Microdroplets (Postprint)

DTIC Science & Technology

2012-05-10

this angle depends linearly on time, α = 2πf t, where f is the frequency of the rotating magnetic field. We assume that the magnetization vector M is... vector B (Figure 1). In order to derive an equation governing the nanorod rotation, it is convenient to count its revolutions with respect to the fixed... vector directed perpendicularly to the plane of the nanorod rotation.27,28 Substituting the definition of angle φ(t) through the angles α(t) and θ(t

DOE Office of Scientific and Technical Information (OSTI.GOV)

Abgrall, N.; Arnquist, I. J.; Avignone, F. T.

We present new limits on exotic keV-scale physics based on 478 kg d of MAJORANA DEMONSTRATOR commissioning data. Constraints at the 90% confidence level are derived on bosonic dark matter (DM) and solar axion couplings, Pauli exclusion principle violating (PEPV) decay, and electron decay using monoenergetic peak signal limits above our background. Our most stringent DM constraints are set for 11.8 keV mass particles, limiting gAe < 4.5 × 10-13 for pseudoscalars and ðα0=αÞ < 9.7 × 10-28 for vectors. We also report a 14.4 keV solar axion coupling limit of geff AN × gAe < 3.8 × 10-17, amore » 1 2 β2 < 8.5 × 10-48 limit on the strength of PEPV electron transitions, and a lower limit on the electron lifetime of τe > 1.2 × 1024 yr for e- → invisible.« less

DOE Office of Scientific and Technical Information (OSTI.GOV)

Abgrall, N.; Arnquist, I. J.; Avignone, F. T.

Here, we present new limits on exotic keV-scale physics based on 478 kg d of Majorana Demonstrator commissioning data. Constraints at the 90% confidence level are derived on bosonic dark matter (DM) and solar axion couplings, Pauli exclusion principle violating (PEPV) decay, and electron decay using monoenergetic peak signal limits above our background. We set our most stringent DM constraints for 11.8 keV mass particles, limiting g A e < 4.5 × 10 -13 for pseudoscalars and ( α ' / α ) < 9.7 × 10 -28 for vectors. We also report a 14.4 keV solar axion coupling limit of gmore » $$eff\\atop{AN}$$ × g A e < 3.8 × 10 -17 , a 1/2 β 2 < 8.5 × 10 - 48 limit on the strength of PEPV electron transitions, and a lower limit on the electron lifetime of τ e > 1.2 × 1 0 24 yr for e - → invisible.« less

A method of recovering the initial vectors of globally coupled map lattices based on symbolic dynamics

NASA Astrophysics Data System (ADS)

Sun, Li-Sha; Kang, Xiao-Yun; Zhang, Qiong; Lin, Lan-Xin

2011-12-01

Based on symbolic dynamics, a novel computationally efficient algorithm is proposed to estimate the unknown initial vectors of globally coupled map lattices (CMLs). It is proved that not all inverse chaotic mapping functions are satisfied for contraction mapping. It is found that the values in phase space do not always converge on their initial values with respect to sufficient backward iteration of the symbolic vectors in terms of global convergence or divergence (CD). Both CD property and the coupling strength are directly related to the mapping function of the existing CML. Furthermore, the CD properties of Logistic, Bernoulli, and Tent chaotic mapping functions are investigated and compared. Various simulation results and the performances of the initial vector estimation with different signal-to-noise ratios (SNRs) are also provided to confirm the proposed algorithm. Finally, based on the spatiotemporal chaotic characteristics of the CML, the conditions of estimating the initial vectors using symbolic dynamics are discussed. The presented method provides both theoretical and experimental results for better understanding and characterizing the behaviours of spatiotemporal chaotic systems.

Integrated Design Analysis and Optimisation of Aircraft Structures (L’Analyse pour la Conception Integree et l’Optimisation des Structures d’Aeronefs)

DTIC Science & Technology

1992-02-01

Division (Code RM) ONERA Office of Aeronautics & Space Technology 29 ave de la Division Leclerc NASA Hq 92320 Chfitillon Washington DC 20546 France United...Vector of thickness variables. V’ = [ t2 ........ tN Vector of thickness changes. AV ’= [rt, 5t2 ......... tNJ TI 7-9 Vector of strain derivatives. F...ds, ds, I d, 1i’,= dt, dr2 ........ dt--N Vector of buckling derivatives. dX d). , dt1 dt2 dtN Then 5F= Vs’i . AV and SX V,’. AV The linearised

Vectorized Jiles-Atherton hysteresis model

NASA Astrophysics Data System (ADS)

Szymański, Grzegorz; Waszak, Michał

2004-01-01

This paper deals with vector hysteresis modeling. A vector model consisting of individual Jiles-Atherton components placed along principal axes is proposed. The cross-axis coupling ensures general vector model properties. Minor loops are obtained using scaling method. The model is intended for efficient finite element method computations defined in terms of magnetic vector potential. Numerical efficiency is ensured by differential susceptibility approach.

Autofocus and fusion using nonlinear correlation

DOE Office of Scientific and Technical Information (OSTI.GOV)

Cabazos-Marín, Alma Rocío; Álvarez-Borrego, Josué, E-mail: josue@cicese.mx; Coronel-Beltrán, Ángel

2014-10-06

In this work a new algorithm is proposed for auto focusing and images fusion captured by microscope's CCD. The proposed algorithm for auto focusing implements the spiral scanning of each image in the stack f(x, y){sub w} to define the V{sub w} vector. The spectrum of the vector FV{sub w} is calculated by fast Fourier transform. The best in-focus image is determined by a focus measure that is obtained by the FV{sub 1} nonlinear correlation vector, of the reference image, with each other FV{sub W} images in the stack. In addition, fusion is performed with a subset of selected imagesmore » f(x, y){sub SBF} like the images with best focus measurement. Fusion creates a new improved image f(x, y){sub F} with the selection of pixels of higher intensity.« less

The Magnetospheric Constellation Mission. Dynamic Response and Coupling Observatory (DRACO): Understanding the Global Dynamics of the Structured Magnetotail

NASA Technical Reports Server (NTRS)

2001-01-01

Magnetospheric Constellation Dynamic Response and Coupling Observatory (DRACO) is the Solar Terrestrial Probe (STP) designed to understand the nonlinear dynamics, responses, and connections within the Earth's structured magnetotail, using a constellation of approximately 50 to 100 distributed vector measurement spacecraft. DRACO will reveal magnetotail processes operating within a domain extending 20 Earth radii (R(sub E)) across the tail and 40 R(sub E)down the tail, on spatial and time scales accessible to global circulation models, i.e., approximately 2 R(sub E) and 10 seconds.

(3+1)-Dimensional topologically massive 2-form gauge theory: geometrical superfield approach

NASA Astrophysics Data System (ADS)

Kumar, R.; Mukhopadhyay, Debmalya

2018-06-01

We derive the complete set of off-shell nilpotent and absolutely anticommuting Becchi-Rouet-Stora-Tyutin (BRST) and anti-BRST symmetry transformations corresponding to the combined "scalar" and "vector" gauge symmetry transformations for the (3+1)-dimensional (4D) topologically massive non-Abelian (B \\wedge F) theory with the help of geometrical superfield formalism. For this purpose, we use three horizontality conditions (HCs). The first HC produces the (anti-)BRST transformations for the 1-form gauge field and corresponding (anti-)ghost fields whereas the second HC yields the (anti-)BRST transformations for 2-form field and associated (anti-)ghost fields. The integrability of second HC produces third HC. The latter HC produces the (anti-)BRST symmetry transformations for the compensating auxiliary vector field and corresponding ghosts. We obtain five (anti-)BRST invariant Curci-Ferrari (CF)-type conditions which emerge very naturally as the off-shoots of superfield formalism. Out of five CF-type conditions, two are fermionic in nature. These CF-type conditions play a decisive role in providing the absolute anticommutativity of the (anti-)BRST transformations and also responsible for the derivation of coupled but equivalent (anti-)BRST invariant Lagrangian densities. Furthermore, we capture the (anti-)BRST invariance of the coupled Lagrangian densities in terms of the superfields and translation generators along the Grassmannian directions θ and \\bar{θ }.

Limits on new forces coexisting with electromagnetism

DOE Office of Scientific and Technical Information (OSTI.GOV)

Kloor, H.; Fischbach, E.; Talmadge, C.

1994-02-15

We consider the limits arising from different electromagnetic systems on the existence of a possible new electromagnetic analogue of the fifth force. Although such a force may have no intrinsic connection to electromagnetism (or gravity), its effects could be manifested through various anomalies in electromagnetic systems, for appropriate values of the coupling strength and range. Our work generalizes that of Bartlett and Loegl (who considered the case of a massive vector field coexisting with massless electrodynamics) to encompass a broad class of phenomenological interactions mediated by both scalar and vector exchanges. By combining data from both gravitational and electromagnetic systems,more » one can eventually set limits on a new force whose range [lambda] extends from the subatomic scale ([lambda][approx]10[sup [minus]15] m) to the astrophysical scale ([lambda][approx]10[sup 12] m).« less

Vector boson star solutions with a quartic order self-interaction

NASA Astrophysics Data System (ADS)

Minamitsuji, Masato

2018-05-01

We investigate boson star (BS) solutions in the Einstein-Proca theory with the quartic order self-interaction of the vector field λ (AμA¯ μ)2/4 and the mass term μ A¯ μAμ/2 , where Aμ is the complex vector field and A¯μ is the complex conjugate of Aμ, and λ and μ are the coupling constant and the mass of the vector field, respectively. The vector BSs are characterized by the two conserved quantities, the Arnowitt-Deser-Misner (ADM) mass and the Noether charge associated with the global U (1 ) symmetry. We show that in comparison with the case without the self-interaction λ =0 , the maximal ADM mass and Noether charge increase for λ >0 and decrease for λ <0 . We also show that there exists the critical central amplitude of the temporal component of the vector field above which there is no vector BS solution, and for λ >0 it can be expressed by the simple analytic expression. For a sufficiently large positive coupling Λ ≔Mpl2λ /(8 π μ2)≫1 , the maximal ADM mass and Noether charge of the vector BSs are obtained from the critical central amplitude and of O [√{λ }Mpl3/μ2ln (λ Mpl2/μ2)] , which is different from that of the scalar BSs, O (√{λϕ }Mpl3/μϕ2) , where λϕ and μϕ are the coupling constant and the mass of the complex scalar field.

Protective immunity against tularemia provided by an adenovirus-vectored vaccine expressing Tul4 of Francisella tularensis.

PubMed

Kaur, Ravinder; Chen, Shan; Arévalo, Maria T; Xu, Qingfu; Chen, Yanping; Zeng, Mingtao

2012-03-01

Francisella tularensis, a category A bioterrorism agent, is a highly infectious organism that is passed on via skin contact and inhalation routes. A live attenuated vaccine strain (LVS) has been developed, but it has not been licensed for public use by the FDA due to safety concerns. Thus, there exists a need for a safer and improved vaccine. In this study, we have constructed a replication-incompetent adenovirus, Ad/opt-Tul4, carrying a codon-optimized gene for expression of a membrane protein, Tul4, of F. tularensis LVS. Its ability to protect against lethal challenge and its immunogenicity were evaluated in a murine model. An intramuscular injection of a single dose (1 × 10(7) PFU) of Ad/opt-Tul4 elicited a robust Tul4-specific antibody response. Assays suggest a Th1-driven response. A single dose elicited 20% protection against challenge with 100 × 50% lethal dose (LD(50)) F. tularensis LVS; two additional booster shots resulted in 60% protection. In comparison, three doses of 5 μg recombinant Tul4 protein did not elicit significant protection against challenge. Therefore, the Ad/opt-Tul4 vaccine was more effective than the protein vaccine, and protection was dose dependent. Compared to LVS, the protection rate is lower, but an adenovirus-vectored vaccine may be more attractive due to its enhanced safety profile and mucosal route of delivery. Furthermore, simple genetic modification of the vaccine may potentially produce antibodies protective against a fully virulent strain of F. tularensis. Our data support the development and further research of an adenovirus-vectored vaccine against Tul4 of F. tularensis LVS.

F-15B ACTIVE - First supersonic yaw vectoring flight

NASA Technical Reports Server (NTRS)

1996-01-01

On Wednesday, April 24, 1996, the F-15 Advanced Control Technology for Integrated Vehicles (ACTIVE) aircraft achieved its first supersonic yaw vectoring flight at Dryden Flight Research Center, Edwards, California. ACTIVE is a joint NASA, U.S. Air Force, McDonnell Douglas Aerospace (MDA) and Pratt & Whitney (P&W) program. The team will assess performance and technology benefits during flight test operations. Current plans call for approximately 60 flights totaling 100 hours. 'Reaching this milestone is very rewarding. We hope to set some more records before we're through,' stated Roger W. Bursey, P&W's pitch-yaw balance beam nozzle (PYBBN) program manager. A pair of P&W PYBBNs vectored (horizontally side-to-side, pitch is up and down) the thrust for the MDA manufactured F-15 research aircraft. Power to reach supersonic speeds was provided by two high-performance F100-PW-229 engines that were modified with the multi-directional thrust vectoring nozzles. The new concept should lead to significant increases in performance of both civil and military aircraft flying at subsonic and supersonic speeds.

Towards efficient photosynthesis: overexpression of Zea mays phosphoenolpyruvate carboxylase in Arabidopsis thaliana.

PubMed

Kandoi, Deepika; Mohanty, Sasmita; Govindjee; Tripathy, Baishnab C

2016-12-01

Plants with C4 photosynthesis are efficient in carbon assimilation and have an advantage over C3 photosynthesis. In C4 photosynthesis, the primary CO 2 fixation is catalyzed by phosphoenolpyruvate carboxylase (PEPC). Here, we show that overexpression of Zea mays PEPC cDNA, under the control of 35 S promoter, in Arabidopsis thaliana resulted in ~7-10 fold higher protein abundance and ~7-10 fold increase in PEPC activity in the transgenic lines than that in the vector control. We suggest that overexpression of PEPC played an anaplerotic role to increase the supply of 4-carbon carboxylic acids, which provided carbon skeletons for increased amino acid and protein synthesis. Higher protein content must have been responsible for increased metabolic processes including chlorophyll biosynthesis, photosynthesis, and respiration. Consequently, the PEPC-overexpressed transgenic plants had higher chlorophyll content, enhanced electron transport rate (ETR), lower non-photochemical quenching (NPQ) of chlorophyll a fluorescence, and a higher performance index (PI) than the vector control. Consistent with these observations, the rate of CO 2 assimilation, the starch content, and the dry weight of PEPC-overexpressed plants increased by 14-18 %, 10-18 %, and 6.5-16 %, respectively. Significantly, transgenics were tolerant to salt stress as they had increased ability to synthesize amino acids, including the osmolyte proline. NaCl (150 mM)-treated transgenic plants had higher variable to maximum Chl a fluorescence (F v /F m ) ratio, higher PI, higher ETR, and lower NPQ than the salt-treated vector controls. These results suggest that expression of C4 photosynthesis enzyme(s) in a C3 plant can improve its photosynthetic capacity with enhanced tolerance to salinity stress.

Determination of the axial-vector weak coupling constant with ultracold neutrons.

PubMed

Liu, J; Mendenhall, M P; Holley, A T; Back, H O; Bowles, T J; Broussard, L J; Carr, R; Clayton, S; Currie, S; Filippone, B W; García, A; Geltenbort, P; Hickerson, K P; Hoagland, J; Hogan, G E; Hona, B; Ito, T M; Liu, C-Y; Makela, M; Mammei, R R; Martin, J W; Melconian, D; Morris, C L; Pattie, R W; Pérez Galván, A; Pitt, M L; Plaster, B; Ramsey, J C; Rios, R; Russell, R; Saunders, A; Seestrom, S J; Sondheim, W E; Tatar, E; Vogelaar, R B; VornDick, B; Wrede, C; Yan, H; Young, A R

2010-10-29

A precise measurement of the neutron decay β asymmetry A₀ has been carried out using polarized ultracold neutrons from the pulsed spallation ultracold neutron source at the Los Alamos Neutron Science Center. Combining data obtained in 2008 and 2009, we report A₀ = -0.119 66±0.000 89{-0.001 40}{+0.001 23}, from which we determine the ratio of the axial-vector to vector weak coupling of the nucleon g{A}/g{V}=-1.275 90{-0.004 45}{+0.004 09}.

Correction of murine hemophilia A following nonmyeloablative transplantation of hematopoietic stem cells engineered to encode an enhanced human factor VIII variant using a safety-augmented retroviral vector

PubMed Central

Ramezani, Ali

2009-01-01

Insertional mutagenesis by retroviral vectors is a major impediment to the clinical application of hematopoietic stem cell gene transfer for the treatment of hematologic disorders. We recently developed an insulated self-inactivating gammaretroviral vector, RMSinOFB, which uses a novel enhancer-blocking element that significantly decreases genotoxicity of retroviral integration. In this study, we used the RMSinOFB vector to evaluate the efficacy of a newly bioengineered factor VIII (fVIII) variant (efVIII)—containing a combination of A1 domain point mutations (L303E/F309S) and an extended partial B domain for improved secretion plus A2 domain mutations (R484A/R489A/P492A) for reduced immunogenicity—toward successful treatment of murine hemophilia A. In cell lines, efVIII was secreted at up to 6-fold higher levels than an L303E/F309S A1 domain–only fVIII variant (sfVIIIΔB). Most important, when compared with a conventional gammaretroviral vector expressing sfVIIIΔB, lower doses of RMSin-efVIII-OFB–transduced hematopoietic stem cells were needed to generate comparable curative fVIII levels in hemophilia A BALB/c mice after reduced-intensity total body irradiation or nonmyeloablative chemotherapy conditioning regimens. These data suggest that the safety-augmented RMSin-efVIII-OFB platform represents an encouraging step in the development of a clinically appropriate gene addition therapy for hemophilia A. PMID:19470695

Comparison of Frankliniella fusca and Frankliniella occidentalis (Thysanoptera: Thripidae) as Vectors for a Peanut Strain of Tomato Spotted Wilt Orthotospovirus.

PubMed

Arthurs, Steven P; Heinz, Kevin M; Mitchell, Forrest L

2018-06-06

Tomato spotted wilt orthotospovirus (TSWV) is a major disease in peanut, Arachis hypogaea L., across peanut producing regions of the United States and elsewhere. Two thrips, Frankliniella fusca Hinds and Frankliniella occidentalis Pergande (Thysanoptera: Thripidae), are considered important vectors of TSWV in peanut in the Southeast. We compared the efficiency of acquisition (by larvae) and transmission (adults) of both thrips species for TSWV (Texas peanut-strain) to leaf disks of peanut (Florunner), as well as to Impatiens walleriana Hook. f. (Dwarf White Baby) and Petunia hybrida Juss. 'Fire Chief' using double antibody sandwich enzyme-linked immunosorbent assay (DAS-ELISA). Both species were competent TSWV vectors in peanut and Impatiens, although F. fusca was the more efficient vector overall, i.e., virus acquisition and transmission rates for F. fusca averaged over several bioassays were 51.7 and 26.6%, respectively, compared with 20.0 and 15.3% for F. occidentalis. Neither species effectively transmitted this TSWV strain to Petunia (i.e., ≤3.6% transmission). We found statistically similar virus acquisition and transmission rates between both sexes for each species. We also detected no differences in TSWV-acquisition and transmission frequency between macropterous and brachypterous (short-wing) forms of F. fusca collected from a field population in south Texas. DAS-ELISA failed to detect low levels of TSWV in a few thrips that subsequently proved to be competent vectors.

Thrust Vectoring on the NASA F-18 High Alpha Research Vehicle

NASA Technical Reports Server (NTRS)

Bowers, Albion H.; Pahle, Joseph W.

1996-01-01

Investigations into a multiaxis thrust-vectoring system have been conducted on an F-18 configuration. These investigations include ground-based scale-model tests, ground-based full-scale testing, and flight testing. This thrust-vectoring system has been tested on the NASA F-18 High Alpha Research Vehicle (HARV). The system provides thrust vectoring in pitch and yaw axes. Ground-based subscale test data have been gathered as background to the flight phase of the program. Tests investigated aerodynamic interaction and vane control effectiveness. The ground-based full-scale data were gathered from static engine runs with image analysis to determine relative thrust-vectoring effectiveness. Flight tests have been conducted at the NASA Dryden Flight Research Center. Parameter identification input techniques have been developed. Individual vanes were not directly controlled because of a mixer-predictor function built into the flight control laws. Combined effects of the vanes have been measured in flight and compared to combined effects of the vanes as predicted by the cold-jet test data. Very good agreement has been found in the linearized effectiveness derivatives.

Curcumin Derivative Epigenetically Reactivates Nrf2 Antioxidative Stress Signaling in Mouse Prostate Cancer TRAMP C1 Cells.

PubMed

Li, Wenji; Su, Zheng-Yuan; Guo, Yue; Zhang, Chengyue; Wu, Renyi; Gao, Linbo; Zheng, Xi; Du, Zhi-Yun; Zhang, Kun; Kong, Ah-Ng

2018-02-19

The carcinogenesis of prostate cancer (PCa) in TRAMP model is highly correlated with hypermethylation in the promoter region of Nrf2 and the accompanying reduced transcription of Nrf2 and its regulated detoxifying genes. We aimed to investigate the effects of (3E,5E)-3,5-bis-(3,4,5-trimethoxybenzylidene)-tetrahydro-thiopyran-4-one (F10) and (3E,5E)-3,5-bis-(3,4,5-trimethoxy-benzylidene)-tetrahydropyran-4-one (E10), two synthetic curcumin derivatives, on restoring Nrf2 activity in TRAMP C1 cells. HepG2-C8 cells transfected with an antioxidant-response element (ARE)-luciferase vector were treated with F10, E10, curcumin, and sulforaphane (SFN) to compare their effects on Nrf2-ARE pathways. We performed real-time quantitative PCR and Western blotting to investigate the effects of F10 and E10 on Nrf2, correlated phase II detoxification genes. We also measured expression and activity of DNMTand HDAC enzymes. Enrichment of H3K27me3 on the promoter region of Nrf2 was explored with a chromatin immunoprecipitation (ChIP) assay. Methylation of the CpG region in Nrf2 promoter was doubly examined by bisulfite genomic sequencing (BGS) and methylation DNA immunoprecipitation (MeDIP). Compared with curcumin and SFN, F10 is more potent in activating Nrf2-ARE pathways. Both F10 and E10 enhanced level of Nrf2 and the correlated phase II detoxifying genes. BGS and MeDIP assays indicated that F10 but not E10 hypomethylated the Nrf2 promoter. F10 also downregulated the protein level of DNMT1, DNMT3a, DNMT3b, HDAC1, HDAC4, and HDAC7 and the activity of DNMTs and HDACs. F10 but not E10 effectively reduced the accumulation of H3k27me3 on the promoter of Nrf2. F10 and E10 can activate the Nrf2-ARE pathway and increase the level of Nrf2 and correlated phase II detoxification genes. The reactivation effect on Nrf2 by F10 in TRAMP C1 may come from demethylation, decrease of HDACs, and inhibition of H3k27me3 accumulation.

Computing the scalar field couplings in 6D supergravity

NASA Astrophysics Data System (ADS)

Saidi, El Hassan

2008-11-01

Using non-chiral supersymmetry in 6D space-time, we compute the explicit expression of the metric the scalar manifold SO(1,1)×{SO(4,20)}/{SO(4)×SO(20)} of the ten-dimensional type IIA superstring on generic K3. We consider as well the scalar field self-couplings in the general case where the non-chiral 6D supergravity multiplet is coupled to generic n vector supermultiplets with moduli space SO(1,1)×{SO(4,n)}/{SO(4)×SO(n)}. We also work out a dictionary giving a correspondence between hyper-Kähler geometry and the Kähler geometry of the Coulomb branch of 10D type IIA on Calabi-Yau threefolds. Others features are also discussed.

[Discrimination of types of polyacrylamide based on near infrared spectroscopy coupled with least square support vector machine].

PubMed

Zhang, Hong-Guang; Yang, Qin-Min; Lu, Jian-Gang

2014-04-01

In this paper, a novel discriminant methodology based on near infrared spectroscopic analysis technique and least square support vector machine was proposed for rapid and nondestructive discrimination of different types of Polyacrylamide. The diffuse reflectance spectra of samples of Non-ionic Polyacrylamide, Anionic Polyacrylamide and Cationic Polyacrylamide were measured. Then principal component analysis method was applied to reduce the dimension of the spectral data and extract of the principal compnents. The first three principal components were used for cluster analysis of the three different types of Polyacrylamide. Then those principal components were also used as inputs of least square support vector machine model. The optimization of the parameters and the number of principal components used as inputs of least square support vector machine model was performed through cross validation based on grid search. 60 samples of each type of Polyacrylamide were collected. Thus a total of 180 samples were obtained. 135 samples, 45 samples for each type of Polyacrylamide, were randomly split into a training set to build calibration model and the rest 45 samples were used as test set to evaluate the performance of the developed model. In addition, 5 Cationic Polyacrylamide samples and 5 Anionic Polyacrylamide samples adulterated with different proportion of Non-ionic Polyacrylamide were also prepared to show the feasibilty of the proposed method to discriminate the adulterated Polyacrylamide samples. The prediction error threshold for each type of Polyacrylamide was determined by F statistical significance test method based on the prediction error of the training set of corresponding type of Polyacrylamide in cross validation. The discrimination accuracy of the built model was 100% for prediction of the test set. The prediction of the model for the 10 mixing samples was also presented, and all mixing samples were accurately discriminated as adulterated samples. The overall results demonstrate that the discrimination method proposed in the present paper can rapidly and nondestructively discriminate the different types of Polyacrylamide and the adulterated Polyacrylamide samples, and offered a new approach to discriminate the types of Polyacrylamide.

The vector radiative transfer numerical model of coupled ocean-atmosphere system using the matrix-operator method

NASA Astrophysics Data System (ADS)

Xianqiang, He; Delu, Pan; Yan, Bai; Qiankun, Zhu

2005-10-01

The numerical model of the vector radiative transfer of the coupled ocean-atmosphere system is developed based on the matrix-operator method, which is named PCOART. In PCOART, using the Fourier analysis, the vector radiative transfer equation (VRTE) splits up into a set of independent equations with zenith angle as only angular coordinate. Using the Gaussian-Quadrature method, VRTE is finally transferred into the matrix equation, which is calculated by using the adding-doubling method. According to the reflective and refractive properties of the ocean-atmosphere interface, the vector radiative transfer numerical model of ocean and atmosphere is coupled in PCOART. By comparing with the exact Rayleigh scattering look-up-table of MODIS(Moderate-resolution Imaging Spectroradiometer), it is shown that PCOART is an exact numerical calculation model, and the processing methods of the multi-scattering and polarization are correct in PCOART. Also, by validating with the standard problems of the radiative transfer in water, it is shown that PCOART could be used to calculate the underwater radiative transfer problems. Therefore, PCOART is a useful tool to exactly calculate the vector radiative transfer of the coupled ocean-atmosphere system, which can be used to study the polarization properties of the radiance in the whole ocean-atmosphere system and the remote sensing of the atmosphere and ocean.

A north-south stationkeeping ion thruster system for ATS-F.

NASA Technical Reports Server (NTRS)

Worlock, R.; James, E.; Ramsey, W.; Trump, G.; Gant, G.; Jan, L.; Bartlett, R.

1972-01-01

An ion thruster system is being developed for the ATS-F satellite to demonstrate the application of ion thruster technology to the synchronous satellite north-south stationkeeping mission. The cesium bombardment ion thruster develops one millipound thrust at 2600 seconds specific impulse and provides thrust vectoring by accelerator electrode displacement. The propellant system is sized for two years operation at 25 percent duty cycle. Power conditioning circuitry is based on transistor inverters switching at 10 kHz. Thirteen command channels allow flexibility in operation; 12 telemetry channels provide information on system performance. Input power is less than 150 watts.

Plasma Wave Turbulence and Particle Heating Caused by Electron Beams, Radiation and Pinches.

DTIC Science & Technology

1979-11-01

current as dP K .2 Td - _c 2 . dt (K 2 (28a) where r 2 2 [ W (r)] , (28b) is the principal wave vector of the emitted radiation, and w p(r) is the...resulting from the angular average of coa 260, Tis research was supported In part by Hughes In the lowest bound state, which t an a state. TD . F. DuBois ad...Pbs.-JEW7, 21. 1127). and Sbsvchenko. V. 1. 1975, Fiz. Plasmy. 1, 10 (English Smith, D. F. 1977, J~ . (Leoaer). 214. L53 . tram!. in Soviet J. Plasim

Analysis of Z 0 couplings to charged leptons

NASA Astrophysics Data System (ADS)

Akrawy, M. Z.; Alexander, G.; Allison, J.; Allport, P. P.; Anderson, K. J.; Armitage, J. C.; Arnison, G. T. J.; Ashton, P.; Azuelos, G.; Baines, J. T. M.; Ball, A. H.; Banks, J.; Barker, G. J.; Barlow, R. J.; Batley, J. R.; Becker, J.; Behnke, T.; Bell, K. W.; Bella, G.; Bethke, S.; Biebel, O.; Binder, U.; Bloodworth, I. J.; Bock, P.; Breuker, H.; Brown, R. M.; Brun, R.; Buijs, A.; Burckhart, H. J.; Capiluppi, P.; Carnegie, R. K.; Carter, A. A.; Carter, J. R.; Chang, C. Y.; Charlton, D. G.; Chrin, J. T. M.; Clarke, P. E. L.; Cohen, I.; Collins, W. J.; Conboy, J. E.; Couch, M.; Coupland, M.; Cuffiani, M.; Dado, S.; Dallavalle, G. M.; Debu, P.; Deninno, M. M.; Dieckmann, A.; Dittmar, M.; Dixit, M. S.; Duchovni, E.; Duerdoth, I. P.; Duerdoth, I. P.; Dumas, D.; El Mamouni, H.; Elcombe, P. A.; Estabrooks, P. G.; Etzion, E.; Fabbri, F.; Farthouat, P.; Fischer, H. M.; Fong, D. G.; French, M. T.; Fukunaga, C.; Gaidot, A.; Ganel, O.; Gary, J. W.; Gascon, J.; Geddes, N. I.; Gee, C. N. P.; Geich-Gimbel, C.; Gensler, S. W.; Gentit, F. X.; Giacomelli, G.; Gibson, V.; Gibson, W. R.; Gillies, J. D.; Goldberg, J.; Goodrick, M. J.; Gorn, W.; Granite, D.; Gross, E.; Grunhaus, J.; Hagedorn, H.; Hagemann, J.; Hansroul, M.; Hargrove, C. K.; Hart, J.; Hattersley, P. M.; Hauschild, M.; Hawkes, C. M.; Heflin, E.; Hemingway, R. J.; Heuer, R. D.; Hill, J. C.; Hillier, S. J.; Ho, C.; Hobbs, J. D.; Hobson, P. R.; Hochman, D.; Holl, B.; Homer, R. J.; Hou, S. R.; Howarth, C. P.; Humbert, R.; Hughes-Jones, R. E.; Igo-Kemenes, P.; Ihssen, H.; Imrie, D. C.; Jawahery, A.; Jeffreys, P. W.; Jeremie, H.; Jimack, M.; Jobes, M.; Jones, R. W. L.; Jovanovic, P.; Karlen, D.; Kawagoe, K.; Kawamoto, T.; Kellogg, R. G.; Kennedy, B. W.; Kleinwort, C.; Klem, D. E.; Knop, G.; Kobayashi, T.; Kokott, T. P.; Köpke, L.; Kowalewski, R.; Kreutzmann, H.; von Krogh, J.; Kroll, J.; Kuwano, M.; Kyberd, P.; Lafferty, G. D.; Lamarche, F.; Larson, W. J.; Layter, J. G.; Le Du, P.; Leblanc, P.; Lee, A. M.; Lehto, M. H.; Lellouch, D.; Lennert, P.; Lessard, L.; Levinson, L.; Lloyd, S. L.; Loebinger, F. K.; Lorah, J. M.; Lorazo, B.; Losty, M. J.; Ludwig, J.; Lupu, N.; Ma, J.; Macbeth, A. A.; Mannelli, M.; Marcellini, S.; Maringer, G.; Martin, A. J.; Martin, J. P.; Mashimo, T.; Mättig, P.; Maur, U.; McMahon, T. J.; McNutt, J. R.; McPherson, A. C.; Meijers, F.; Menszner, D.; Merritt, F. S.; Mes, H.; Michelini, A.; Middleton, R. P.; Mikenberg, G.; Miller, D. J.; Milstene, C.; Minowa, M.; Mohr, W.; Montanari, A.; Mori, T.; Moss, M. W.; Murphy, P. G.; Murray, W. J.; Nellen, B.; Nguyen, H. H.; Nozaki, M.; O'Dowd, A. J. P.; O'Neale, S. W.; O'Neill, B. P.; Oakham, F. G.; Odorici, F.; Ogg, M.; Oh, H.; OregliaP, M. J.; Orito, S.; Pansart, J. P.; Patrick, G. N.; Pawley, S. J.; Pfister, P.; Pilcher, J. E.; Pinfold, J. L.; Plane, D. E.; Poli, B.; Pouladdej, A.; Pritchard, T. W.; Quast, G.; Raab, J.; Redmond, M. W.; Rees, D. L.; Regimbald, M.; Riles, K.; Roach, C. M.; Robins, S. A.; Rollnik, A.; Roney, J. M.; Rossberg, S.; Rossi, A. M.; Routenburg, P.; Runge, K.; Runolfsson, O.; Sanghera, S.; Sansum, R. A.; Sasaki, M.; Saunders, B. J.; Schaile, A. D.; Schaile, O.; Schappert, W.; Scharff-Hansen, P.; von der Schmitt, H.; Schreiber, S.; Schwarz, J.; Shapira, A.; Shen, B. C.; Sherwood, P.; Simon, A.; Singh, P.; Siroli, G. P.; Skuja, A.; Smith, A. M.; Smith, T. J.; Snow, G. A.; Spreadbury, E. J.; Springer, R. W.; Sproston, M.; Stephens, K.; Stier, H. E.; Ströhmer, R.; Strom, D.; Takeda, H.; Takeshita, T.; Tsukamoto, T.; Turner, M. F.; Tysarczyk-Niemeyer, G.; Van den plas, D.; VanDalen, G. J.; Vasseur, G.; Virtue, C. J.; Wagner, A.; Wahl, C.; Ward, C. P.; Ward, D. R.; Waterhouse, J.; Watkins, P. M.; Watson, A. T.; Watson, N. K.; Weber, M.; Weisz, S.; Wells, P. S.; Wermes, N.; Weymann, M.; Wilson, G. W.; Wilson, J. A.; Wingerter, I.; Winterer, V.-H.; Wood, N. C.; Wotton, S.; Wuensch, B.; Wyatt, T. R.; Yaari, R.; Yang, Y.; Yekutieli, G.; Yoshida, T.; Zeuner, W.; Zorn, G. T.; OPAL Collaboration

1990-09-01

The couplings of the Z 0 to charged leptons are studied using measurements of the lepton pair cross sections and forward-backward asymmetries at centre of mass energies near to the mass of the Z 0. The data are consistent with lepton universality. Using a parametrisation of the lepton pair differential cross section which assumes that the Z 0 has only vector and axial couplings to leptons, the charged leptonic partial decay width of the Z 0 is determined to be Г ol+ol- = 83.1±1.9 MeV and the square of the product of the effective axial vector and vector coupling constants of the Z 0 to charged leptons to be ǎ2olvˇ2ol = 0.0039± 0.0083 , in agreement with the standard model. A parametrisation in the form of the improved Born approximation gives effective leptonic axial vector and vector coupling constants ǎ2ol = 0.998±0.024 and vˇ2ol = 0.0044±0.0083 . In the framework of the standard model, the values of the parameters ϱ z and sin 2overlineθw are found to be 0.998±0.024 and 0.233 +0.045-0.012 respectively. Using the relationship in the minimal standard model between ϱ z and sin 2overlineθw, the results sin 2overlineθSMw = 0.233 +0.007-0.006 is obtained. Our previously published measurement of the ratio of the hadronic to the leptonic partial width of the Z 0 is update: Rz = 21.72 +0.71-0.65.

An ultra low power feature extraction and classification system for wearable seizure detection.

PubMed

Page, Adam; Pramod Tim Oates, Siddharth; Mohsenin, Tinoosh

2015-01-01

In this paper we explore the use of a variety of machine learning algorithms for designing a reliable and low-power, multi-channel EEG feature extractor and classifier for predicting seizures from electroencephalographic data (scalp EEG). Different machine learning classifiers including k-nearest neighbor, support vector machines, naïve Bayes, logistic regression, and neural networks are explored with the goal of maximizing detection accuracy while minimizing power, area, and latency. The input to each machine learning classifier is a 198 feature vector containing 9 features for each of the 22 EEG channels obtained over 1-second windows. All classifiers were able to obtain F1 scores over 80% and onset sensitivity of 100% when tested on 10 patients. Among five different classifiers that were explored, logistic regression (LR) proved to have minimum hardware complexity while providing average F-1 score of 91%. Both ASIC and FPGA implementations of logistic regression are presented and show the smallest area, power consumption, and the lowest latency when compared to the previous work.

Widespread Pyrethroid and DDT Resistance in the Major Malaria Vector Anopheles funestus in East Africa Is Driven by Metabolic Resistance Mechanisms

PubMed Central

Mulamba, Charles; Riveron, Jacob M.; Ibrahim, Sulaiman S.; Irving, Helen; Barnes, Kayla G.; Mukwaya, Louis G.; Birungi, Josephine; Wondji, Charles S.

2014-01-01

Background Establishing the extent, geographical distribution and mechanisms of insecticide resistance in malaria vectors is a prerequisite for resistance management. Here, we report a widespread distribution of insecticide resistance in the major malaria vector An. funestus across Uganda and western Kenya under the control of metabolic resistance mechanisms. Methodology/Principal Findings Female An. funestus collected throughout Uganda and western Kenya exhibited a Plasmodium infection rate between 4.2 to 10.4%. Widespread resistance against both type I (permethrin) and II (deltamethrin) pyrethroids and DDT was observed across Uganda and western Kenya. All populations remain highly susceptible to carbamate, organophosphate and dieldrin insecticides. Knockdown resistance plays no role in the pyrethroid and DDT resistance as no kdr mutation associated with resistance was detected despite the presence of a F1021C replacement. Additionally, no signature of selection was observed on the sodium channel gene. Synergist assays and qRT-PCR indicated that metabolic resistance plays a major role notably through elevated expression of cytochrome P450s. DDT resistance mechanisms differ from West Africa as the L119F-GSTe2 mutation only explains a small proportion of the genetic variance to DDT resistance. Conclusion The extensive distribution of pyrethroid and DDT resistance in East African An. funestus populations represents a challenge to the control of this vector. However, the observed carbamate and organophosphate susceptibility offers alternative solutions for resistance management. PMID:25333491

Viability of strongly coupled scenarios with a light Higgs-like boson.

PubMed

Pich, Antonio; Rosell, Ignasi; Sanz-Cillero, Juan José

2013-05-03

We present a one-loop calculation of the oblique S and T parameters within strongly coupled models of electroweak symmetry breaking with a light Higgs-like boson. We use a general effective Lagrangian, implementing the chiral symmetry breaking SU(2)(L) [Symbol: see text]SU(2)(R) → SU(2)(L+R) with Goldstone bosons, gauge bosons, the Higgs-like scalar, and one multiplet of vector and axial-vector massive resonance states. Using a dispersive representation and imposing a proper ultraviolet behavior, we obtain S and T at the next-to-leading order in terms of a few resonance parameters. The experimentally allowed range forces the vector and axial-vector states to be heavy, with masses above the TeV scale, and suggests that the Higgs-like scalar should have a WW coupling close to the standard model one. Our conclusions are generic and apply to more specific scenarios such as the minimal SO(5)/SO(4) composite Higgs model.

Low-k SiOCH Film Etching Process and Its Diagnostics Employing Ar/C5F10O/N2 Plasma

NASA Astrophysics Data System (ADS)

Nagai, Mikio; Hayashi, Takayuki; Hori, Masaru; Okamoto, Hidekazu

2006-09-01

We proposed an environmental harmonic etching gas of C5F10O (CF3CF2CF2OCFCF2), and demonstrated the etching of low-k SiOCH films employing a dual-frequency capacitively coupled etching system. Dissociative ionization cross sections for the electron impact ionizations of C5F10O and c-C4F8 gases have been measured by quadrupole mass spectroscopy (QMS). The dissociative ionization cross section of CF3+ from C5F10O gas was much higher than those of other ionic species, and 10 times higher than that of CF3+ from C4F8 gas. CF3+ is effective for increasing the etching rate of SiO2. As a result, the etching rate of SiOCH films using Ar/C5F10O/N2 plasma was about 1000 nm/min, which is much higher than that using Ar/C4F8/N2 plasma. The behaviours of fluorocarbon radicals in Ar/C5F10O/N2 plasma, which were measured by infrared diode laser absorption spectroscopy, were similar to those in Ar/C4F8/N2 plasma. The densities of CF and CF3 radicals were markedly decreased with increasing N2 flow rate. Etching rate was controlled by N2 flow rate. A vertical profile of SiOCH with a high etching rate and less microloading was realized using Ar/C5F10O/N2 plasma chemistry.

Transmission competency of single-female Xiphinema index lines for Grapevine fanleaf virus.

PubMed

Demangeat, Gérard; Komar, Véronique; Van-Ghelder, Cyril; Voisin, Roger; Lemaire, Olivier; Esmenjaud, Daniel; Fuchs, Marc

2010-04-01

Grapevine fanleaf virus (GFLV) is vectored specifically from grapevine to grapevine by the ectoparasitic nematode Xiphinema index. Limited information is available on the vector competency of X. index populations from diverse geographical origins. We determined the transmissibility of two GFLV strains showing 4.6% amino acid divergence within their coat protein (e.g., strains F13 and GHu) by seven clonal lines of X. index developed from seven distinct populations from the Mediterranean basin (Cyprus, southern France, Israel, Italy, and Spain), northern France, and California. X. index lines derived from single adult females were produced on fig (Ficus carica) plants to obtain genetically homogenous aviruliferous clones. A comparative reproductive rate analysis on Vitis rupestris du Lot and V. vinifera cv. Cabernet Sauvignon showed significant differences among clones, with the single-female Cyprus line showing the highest rate (30-fold the initial population) and the Spain and California lines showing the lowest rate (10-fold increase), regardless of the grapevine genotype. However, there was no differential vector competency among the seven X. index lines for GFLV strains F13 and GHu. The implications of our findings for the dynamic of GFLV transmission in vineyards and screening of Vitis spp. for resistance to GFLV are discussed.

Anisotropic optical absorption induced by Rashba spin-orbit coupling in monolayer phosphorene

NASA Astrophysics Data System (ADS)

Li, Yuan; Li, Xin; Wan, Qi; Bai, R.; Wen, Z. C.

2018-04-01

We obtain the effective Hamiltonian of the phosphorene including the effect of Rashba spin-orbit coupling in the frame work of the low-energy theory. The spin-splitting energy bands show an anisotropy feature for the wave vectors along kx and ky directions, where kx orients to ΓX direction in the k space. We numerically study the optical absorption of the electrons for different wave vectors with Rashba spin-orbit coupling. We find that the spin-flip transition from the valence band to the conduction band induced by the circular polarized light closes to zero with increasing the x-component wave vector when ky equals to zero, while it can be significantly increased to a large value when ky gets a small value. When the wave vector varies along the ky direction, the spin-flip transition can also increase to a large value, however, which shows an anisotropy feature for the optical absorption. Especially, the spin-conserved transitions keep unchanged and have similar varying trends for different wave vectors. This phenomenon provides a novel route for the manipulation of the spin-dependent property of the fermions in the monolayer phosphorene.

A Single Crossing-Over Event in Voltage-Sensitive Na+ Channel Genes May Cause Critical Failure of Dengue Mosquito Control by Insecticides

PubMed Central

Hirata, Koichi; Komagata, Osamu; Itokawa, Kentaro; Yamamoto, Atsushi; Tomita, Takashi; Kasai, Shinji

2014-01-01

The voltage-sensitive sodium (Na+) channel (Vssc) is the target site of pyrethroid insecticides. Pest insects develop resistance to this class of insecticide by acquisition of one or multiple amino acid substitution(s) in this channel. In Southeast Asia, two major Vssc types confer pyrethroid resistance in the dengue mosquito vector Aedes aegypti, namely, S989P+V1016G and F1534C. We expressed several types of Vssc in Xenopus oocytes and examined the effect of amino acid substitutions in Vssc on pyrethroid susceptibilities. S989P+V1016G and F1534C haplotypes reduced the channel sensitivity to permethrin by 100- and 25-fold, respectively, while S989P+V1016G+F1534C triple mutations reduced the channel sensitivity to permethrin by 1100-fold. S989P+V1016G and F1534C haplotypes reduced the channel sensitivity to deltamethrin by 10- and 1-fold (no reduction), respectively, but S989P+V1016G+F1534C triple mutations reduced the channel sensitivity to deltamethrin by 90-fold. These results imply that pyrethroid insecticides are highly likely to lose their effectiveness against A. aegypti if such a Vssc haplotype emerges as the result of a single crossing-over event; thus, this may cause failure to control this key mosquito vector. Here, we strongly emphasize the importance of monitoring the occurrence of triple mutations in Vssc in the field population of A. aegypti. PMID:25166902

Optical emission spectroscopic studies and comparisons of CH{sub 3}F/CO{sub 2} and CH{sub 3}F/O{sub 2} inductively coupled plasmas

DOE Office of Scientific and Technical Information (OSTI.GOV)

Lou, Qiaowei; Kaler, Sanbir; Donnelly, Vincent M., E-mail: vmdonnelly@uh.edu

2015-03-15

A CH{sub 3}F/CO{sub 2} inductively coupled plasma (ICP), sustained in a compact plasma reactor, was investigated as a function of power (5–400 W) and feed gas composition, at a pressure of 10 mTorr, using optical emission spectroscopy and rare gas actinometry. Number densities of H, F, and O increased rapidly between 74% and 80% CO{sub 2}, ascribed to the transition from polymer-covered to polymer-free reactor walls, similar to that found previously in CH{sub 3}F/O{sub 2} ICPs at 48% O{sub 2}. Below 40% O{sub 2} or CO{sub 2}, relative emission intensity ratios were almost identical for most key species in CH{sub 3}F/O{submore » 2} and CH{sub 3}F/CO{sub 2} ICPs except for higher OH/Xe (a qualitative measure of OH and H{sub 2}O densities) over the full range of CH{sub 3}F/O{sub 2} composition. The number density of H, F, and O increased with power in CH{sub 3}F/CO{sub 2} (20%/80%) plasmas (polymer-free walls), reaching 4.0, 0.34, and 1.6 × 10{sup 13}/cm{sup 3}, respectively, at 300 W. The CO number density increased with power and was estimated, based on self-actinometry, to be 8.8 × 10{sup 13}/cm{sup 3} at 300 W. The CO{sub 2} number density was independent of power below 40 W (where very little decomposition occurred), and then decreased rapidly with increasing power, reaching 2.8 × 10{sup 13}/cm{sup 3} at 300 W, corresponding to 83% dissociation. Films deposited on p-Si, 10 cm from the open, downstream end of the plasma reactor, were analyzed by x-ray photoelectron spectroscopy. Between 10% and 40% CO{sub 2} or O{sub 2} addition to CH{sub 3}F, film deposition rates fell and O content in the films increased. Faster deposition rates in CH{sub 3}F/CO{sub 2} plasmas were ascribed mainly to a larger thermodynamic driving force to form solid carbon, compared with CH{sub 3}F/O{sub 2} plasmas. Oxygen content in the films increased with increasing CO{sub 2} or O{sub 2} addition, but for the same deposition rate, no substantial differences were observed in the composition of the films.« less

Vector-like quarks and leptons, SU(5) ⊗ SU(5) grand unification, and proton decay

NASA Astrophysics Data System (ADS)

Lee, Chang-Hun; Mohapatra, Rabindra N.

2017-02-01

SU(5) ⊗ SU(5) provides a minimal grand unification scheme for fermions and gauge forces if there are vector-like quarks and leptons in nature. We explore the gauge coupling unification in a non-supersymmetric model of this type, and study its implications for proton decay. The properties of vector-like quarks and intermediate scales that emerge from coupling unification play a central role in suppressing proton decay. We find that in this model, the familiar decay mode p → e +π0 may have a partial lifetime within the reach of currently planned experiments.

High-order rogue waves in vector nonlinear Schrödinger equations.

PubMed

Ling, Liming; Guo, Boling; Zhao, Li-Chen

2014-04-01

We study the dynamics of high-order rogue waves (RWs) in two-component coupled nonlinear Schrödinger equations. We find that four fundamental rogue waves can emerge from second-order vector RWs in the coupled system, in contrast to the high-order ones in single-component systems. The distribution shape can be quadrilateral, triangle, and line structures by varying the proper initial excitations given by the exact analytical solutions. The distribution pattern for vector RWs is more abundant than that for scalar rogue waves. Possibilities to observe these new patterns for rogue waves are discussed for a nonlinear fiber.

[GPER silence inhibits the stimulation of growth and inhibition of apoptosis induced by tamoxifen in breast cancer-associated fibroblasts].

PubMed

Yan, Yuzhao; Yu, Tenghua; Tu, Gang; Liu, Manran; Yuan, Jie; Yang, Guanglun

2015-09-01

To construct a lentiviral vector (Lenti-GPER-shRNA) targeting G-protein coupled estrogen receptor (GPER) and explore the role of GPER in the effect of tamoxifen on cell proliferation and apoptosis in breast cancer associated fibroblasts (BCAFs). The target sequence of GPER gene and negative control were cloned into lentiviral vectors. The recombinant lentivirus and control were extracted after HEK293T cells were transfected with the recombinant vector and helper vectors. After infection of BCAFs with the GPER lentiviral vector under the best interfering condition, GPER expression was detected by real-time quantitative PCR and Western blotting. BCAFs were divided into negative control group, GPER-RNAi group, negative control combined with tamoxifen (10(-8) mmol/L) group and GPER-RNAi combined with tamoxifen (10(-8) mmol/L) group. CCK-8 assay was used to detect the proliferation and annexin V-fluorescein isothiocyanate/propidium iodide (annexin V-FITC/PI) combined with flow cytometry was used to detect the apoptosis of BCAFs after the treatment of tamoxifen. Lenti-GPER-shRNA significantly interfered the expression of GPER in BCAFs. Tamoxifen promoted the growth of BCAFs, which could be attenuated by knockdown of GPER. Moreover, the apoptosis of BCAFs was reduced by tamoxifen, which was also reversed by knockdown of GPER. Lenti-GPER-shRNA could effectively silence the GPER expression in BCAFs. The ability of tamoxifen to accelerate cell proliferation and decrease cell apoptosis could be weakened by knockdown of GPER.

Search for the U Boson in the Process e(+e^-) -> mu (+) mu (-) gamma , U -> mu (+mu) (-) with the KLOE Detector

NASA Astrophysics Data System (ADS)

Curciarello, F.

We present a search for a new light vector boson, carrier of a "dark force" between WIMPs, with the KLOE detector at \\DA$\\Phi$NE. We analyzed $e^+ e^- \\to \\mu^+ \\mu^- \\gamma$ ISR events corresponding to an integrated luminosity of $239$ pb$^{-1}$ to find evidence for the $e^+ e^- \\to U\\gamma ,\\,\\, U\\to\\mu^+\\mu^-$ process. We found no $U$ vector boson signal and set a 90% CL upper limit on the ratio of the U boson and photon coupling constants between 1.6$\\times10^{-5}$ to 8.6$\\times10^{-7}$ in the mass region $520

A new methodical approach in neuroscience: assessing inter-personal brain coupling using functional near-infrared imaging (fNIRI) hyperscanning.

PubMed

Scholkmann, Felix; Holper, Lisa; Wolf, Ursula; Wolf, Martin

2013-11-27

Since the first demonstration of how to simultaneously measure brain activity using functional magnetic resonance imaging (fMRI) on two subjects about 10 years ago, a new paradigm in neuroscience is emerging: measuring brain activity from two or more people simultaneously, termed "hyperscanning". The hyperscanning approach has the potential to reveal inter-personal brain mechanisms underlying interaction-mediated brain-to-brain coupling. These mechanisms are engaged during real social interactions, and cannot be captured using single-subject recordings. In particular, functional near-infrared imaging (fNIRI) hyperscanning is a promising new method, offering a cost-effective, easy to apply and reliable technology to measure inter-personal interactions in a natural context. In this short review we report on fNIRI hyperscanning studies published so far and summarize opportunities and challenges for future studies.

NASA Tech Briefs, November 2009

NASA Technical Reports Server (NTRS)

2009-01-01

Topics covered include: Cryogenic Chamber for Servo-Hydraulic Materials Testing; Apparatus Measures Thermal Conductance Through a Thin Sample from Cryogenic to Room Temperature; Rover Attitude and Pointing System Simulation Testbed; Desktop Application Program to Simulate Cargo-Air-Drop Tests; Multimodal Friction Ignition Tester; Small-Bolt Torque-Tension Tester; Integrated Spacesuit Audio System Enhances Speech Quality and Reduces Noise; Hardware Implementation of a Bilateral Subtraction Filter; Simple Optoelectronic Feedback in Microwave Oscillators; Small X-Band Oscillator Antennas; Free-Space Optical Interconnect Employing VCSEL Diodes; Discrete Fourier Transform Analysis in a Complex Vector Space; Miniature Scroll Pumps Fabricated by LIGA; Self-Assembling, Flexible, Pre-Ceramic Composite Preforms; Flight-speed Integral Image Analysis Toolkit; Work Coordination Engine; Multi-Mission Automated Task Invocation Subsystem; Autonomously Calibrating a Quadrupole Mass Spectrometer; Determining Spacecraft Reaction Wheel Friction Parameters; Composite Silica Aerogels Opacified with Titania; Multiplexed Colorimetric Solid-Phase Extraction; Detecting Airborne Mercury by Use of Polymer/Carbon Films; Lattice-Matched Semiconductor Layers on Single Crystalline Sapphire Substrate; Pressure-Energized Seal Rings to Better Withstand Flows; Rollerjaw Rock Crusher; Microwave Sterilization and Depyrogenation System; Quantifying Therapeutic and Diagnostic Efficacy in 2D Microvascular Images; NiF2/NaF:CaF2/Ca Solid-State High-Temperature Battery Cells; Critical Coupling Between Optical Fibers and WGM Resonators; Microwave Temperature Profiler Mounted in a Standard Airborne Research Canister; Alternative Determination of Density of the Titan Atmosphere; Solar Rejection Filter for Large Telescopes; Automated CFD for Generation of Airfoil Performance Tables; Progressive Classification Using Support Vector Machines; Active Learning with Irrelevant Examples; A Data Matrix Method for Improving the Quantification of Element Percentages of SEM/EDX Analysis; Deployable Shroud for the International X-Ray Observatory; Improved Model of a Mercury Ring Damper; Optoelectronic pH Meter: Further Details; X-38 Advanced Sublimator; and Solar Simulator Represents the Mars Surface Solar Environment.

Centromere protein F includes two sites that couple efficiently to depolymerizing microtubules

PubMed Central

Volkov, Vladimir A.; Grissom, Paula M.; Arzhanik, Vladimir K.; Zaytsev, Anatoly V.; Renganathan, Kutralanathan; McClure-Begley, Tristan; Old, William M.; Ahn, Natalie

2015-01-01

Firm attachments between kinetochores and dynamic spindle microtubules (MTs) are important for accurate chromosome segregation. Centromere protein F (CENP-F) has been shown to include two MT-binding domains, so it may participate in this key mitotic process. Here, we show that the N-terminal MT-binding domain of CENP-F prefers curled oligomers of tubulin relative to MT walls by approximately fivefold, suggesting that it may contribute to the firm bonds between kinetochores and the flared plus ends of dynamic MTs. A polypeptide from CENP-F’s C terminus also bound MTs, and either protein fragment diffused on a stable MT wall. They also followed the ends of dynamic MTs as they shortened. When either fragment was coupled to a microbead, the force it could transduce from a shortening MT averaged 3–5 pN but could exceed 10 pN, identifying CENP-F as a highly effective coupler to shortening MTs. PMID:26101217

The mathematical modeling of the experiment on the determination of correlation coefficients in neutron beta-decay

NASA Astrophysics Data System (ADS)

Serebrov, A. P.; Zherebtsov, O. M.; Klyushnikov, G. N.

2018-05-01

An experiment on the measurement of the ratio of the axial coupling constant to the vector one is under development. The main idea of the experiment is to measure the values of A and B in the same setup. An additional measurement of the polarization is not necessary. The accuracy achieved to date in measuring λ is 2 × 10-3. It is expected that in the experiment the accuracy will be of the order of 10-4. Some particular problems of mathematical modeling concerning the experiment on the measurement of the ratio of the axial coupling constant to the vector one are considered. The force lines for the given tabular field of a magnetic trap are studied. The dependences of the longitudinal and transverse field non-uniformity coefficients on the coordinates are regarded. A special computational algorithm based on the law of a charged particle motion along a local magnetic force line is performed for the calculation of the electrons and protons motion time as well as for the evaluation of the total number of electrons colliding with the detector surface. The average values of the cosines of the angles with the coefficients of a, A and B have been estimated.

Novel positioning method using Gaussian mixture model for a monolithic scintillator-based detector in positron emission tomography

NASA Astrophysics Data System (ADS)

Bae, Seungbin; Lee, Kisung; Seo, Changwoo; Kim, Jungmin; Joo, Sung-Kwan; Joung, Jinhun

2011-09-01

We developed a high precision position decoding method for a positron emission tomography (PET) detector that consists of a thick slab scintillator coupled with a multichannel photomultiplier tube (PMT). The DETECT2000 simulation package was used to validate light response characteristics for a 48.8 mm×48.8 mm×10 mm slab of lutetium oxyorthosilicate coupled to a 64 channel PMT. The data are then combined to produce light collection histograms. We employed a Gaussian mixture model (GMM) to parameterize the composite light response with multiple Gaussian mixtures. In the training step, light photons acquired by N PMT channels was used as an N-dimensional feature vector and were fed into a GMM training model to generate optimal parameters for M mixtures. In the positioning step, we decoded the spatial locations of incident photons by evaluating a sample feature vector with respect to the trained mixture parameters. The average spatial resolutions after positioning with four mixtures were 1.1 mm full width at half maximum (FWHM) at the corner and 1.0 mm FWHM at the center section. This indicates that the proposed algorithm achieved high performance in both spatial resolution and positioning bias, especially at the corner section of the detector.

Hidden and antiferromagnetic order as a rank-5 superspin in URu2Si2

NASA Astrophysics Data System (ADS)

Rau, Jeffrey G.; Kee, Hae-Young

2012-06-01

We propose a candidate for the hidden order in URu2Si2: a rank-5 E type spin-density wave between uranium 5f crystal-field doublets Γ7(1) and Γ7(2), breaking time-reversal and lattice tetragonal symmetry in a manner consistent with recent torque measurements [Okazaki , ScienceSCIEAS0036-807510.1126/science.1197358 331, 439 (2011)]. We argue that coupling of this order parameter to magnetic probes can be hidden by crystal-field effects, while still having significant effects on transport, thermodynamics, and magnetic susceptibilities. In a simple tight-binding model for the heavy quasiparticles, we show the connection between the hidden order and antiferromagnetic phases arises since they form different components of this single rank-5 pseudospin vector. Using a phenomenological theory, we show that the experimental pressure-temperature phase diagram can be qualitatively reproduced by tuning terms which break pseudospin rotational symmetry. As a test of our proposal, we predict the presence of small magnetic moments in the basal plane oriented in the [110] direction ordered at the wave vector (0,0,1).

Old and new physics interpretations of the NuTeV anomaly

NASA Astrophysics Data System (ADS)

Davidson, Sacha; Forte, Stefano; Gambino, Paolo; Rius, Nuria; Strumia, Alessandro

2002-02-01

We discuss whether the NuTeV anomaly can be explained, compatibly with all other data, by QCD effects (maybe, if the strange sea is asymmetric, or there is a tiny violation of isospin), new physics in propagators or couplings of the vector bosons (not really), loops of supersymmetric particles (no), dimension six operators (yes, for one specific SU(2)L-invariant operator), leptoquarks (not in a minimal way), extra U(1) gauge bosons (maybe: an unmixed Z' coupled to B-3Lμ also increases the muon g-2 by about 10-9 and gives a `burst' to cosmic rays above the GZK cutoff).

Automated radiosynthesis of no-carrier-added 4-[18F]fluoroiodobenzene: a versatile building block in 18F radiochemistry.

PubMed

Way, Jenilee Dawn; Wuest, Frank

2014-02-01

4-[18F]Fluoroiodobenzene ([18F]FIB) is a versatile building block in 18F radiochemistry used in various transition metal-mediated C-C and C-N cross-coupling reactions and [18F]fluoroarylation reactions. Various synthesis routes have been described for the preparation of [18F]FIB. However, to date, no automated synthesis of [18F]FIB has been reported to allow access to larger amounts of [18F]FIB in high radiochemical and chemical purity. Herein, we describe an automated synthesis of no-carrier-added [18F]FIB on a GE TRACERlab™ FX automated synthesis unit starting from commercially available(4-iodophenyl)diphenylsulfonium triflate as the labelling precursor. [18F]FIB was prepared in high radiochemical yields of 89 ± 10% (decay-corrected, n = 7) within 60 min, including HPLC purification. The radiochemical purity exceeded 95%, and specific activity was greater than 40 GBq/μmol. Typically, from an experiment, 6.4 GBq of [18F]FIB could be obtained starting from 10.4 GBq of [18F]fluoride.

Observable cosmological vector mode in the dark ages

NASA Astrophysics Data System (ADS)

Saga, Shohei

2016-09-01

The second-order vector mode is inevitably induced from the coupling of first-order scalar modes in cosmological perturbation theory and might hinder a possible detection of primordial gravitational waves from inflation through 21 cm lensing observations. Here, we investigate the weak lensing signal in 21 cm photons emitted by neutral hydrogen atoms in the dark ages induced by the second-order vector mode by decomposing the deflection angle of the 21 cm lensing signal into the gradient and curl modes. The curl mode is a good tracer of the cosmological vector and tensor modes since the scalar mode does not induce the curl one. By comparing angular power spectra of the 21 cm lensing curl mode induced by the second-order vector mode and primordial gravitational waves whose amplitude is parametrized by the tensor-to-scalar ratio r , we find that the 21 cm curl mode from the second-order vector mode dominates over that from primordial gravitational waves on almost all scales if r ≲10-5. If we use the multipoles of the power spectrum up to ℓmax=1 05 and 1 06 in reconstructing the curl mode from 21 cm temperature maps, the signal-to-noise ratios of the 21 cm curl mode from the second-order vector mode achieve S /N ≈0.46 and 73, respectively. Observation of 21 cm radiation is, in principle, a powerful tool to explore not only the tensor mode but also the cosmological vector mode.

Stability of Horndeski vector-tensor interactions

DOE Office of Scientific and Technical Information (OSTI.GOV)

Jiménez, Jose Beltrán; Durrer, Ruth; Heisenberg, Lavinia

2013-10-01

We study the Horndeski vector-tensor theory that leads to second order equations of motion and contains a non-minimally coupled abelian gauge vector field. This theory is remarkably simple and consists of only 2 terms for the vector field, namely: the standard Maxwell kinetic term and a coupling to the dual Riemann tensor. Furthermore, the vector sector respects the U(1) gauge symmetry and the theory contains only one free parameter, M{sup 2}, that controls the strength of the non-minimal coupling. We explore the theory in a de Sitter spacetime and study the presence of instabilities and show that it corresponds tomore » an attractor solution in the presence of the vector field. We also investigate the cosmological evolution and stability of perturbations in a general FLRW spacetime. We find that a sufficient condition for the absence of ghosts is M{sup 2} > 0. Moreover, we study further constraints coming from imposing the absence of Laplacian instabilities. Finally, we study the stability of the theory in static and spherically symmetric backgrounds (in particular, Schwarzschild and Reissner-Nordström-de Sitter). We find that the theory, quite generally, do have ghosts or Laplacian instabilities in regions of spacetime where the non-minimal interaction dominates over the Maxwell term. We also calculate the propagation speed in these spacetimes and show that superluminality is a quite generic phenomenon in this theory.« less

20F beta spectrum shape and weak interaction tests

NASA Astrophysics Data System (ADS)

Voytas, Paul; George, Elizabeth; Chuna, Thomas; Naviliat-Cuncic, Oscar; Hughes, Max; Huyan, Xueying; Minamisono, Kei; Paulauskas, Stanley

2016-09-01

Precision measurements of the shape of beta spectra can test our understanding of the weak interaction. We are carrying out a measurement of the shape of the energy spectrum of β particles from 20F decay. The primary motivation is to test the so-called strong form of the conserved vector current (CVC) hypothesis. The measurement should also enable us to place competitive limits on the contributions of exotic tensor couplings in beta decay. We aim to achieve a relative precision better than 3% on the linear contribution to the shape. This represents an order of magnitude improvement compared to previous experiments in 20F. In order to control systematic effects, we are using a technique that takes advantage of high energy radioactive beams at the NSCL to implant the decaying nuclei in scintillation detectors deeply enough that the emitted beta particles cannot escape. The β-particle energy is measured with the implantation detector after switching off the implantation beam. Ancillary detectors are used to identify the 1.633-MeV γ-rays following the 20F β decay for coincidence measurements in order to tag the transition of interest and to reduce backgrounds. We report on the status of the analysis. Supported in part with Awards from the NSCL PAC and the National Science Foundation under Grant No. PHY-1506084.

Initial Flight Test Evaluation of the F-15 ACTIVE Axisymmetric Vectoring Nozzle Performance

NASA Technical Reports Server (NTRS)

Orme, John S.; Hathaway, Ross; Ferguson, Michael D.

1998-01-01

A full envelope database of a thrust-vectoring axisymmetric nozzle performance for the Pratt & Whitney Pitch/Yaw Balance Beam Nozzle (P/YBBN) is being developed using the F-15 Advanced Control Technology for Integrated Vehicles (ACTIVE) aircraft. At this time, flight research has been completed for steady-state pitch vector angles up to 20' at an altitude of 30,000 ft from low power settings to maximum afterburner power. The nozzle performance database includes vector forces, internal nozzle pressures, and temperatures all of which can be used for regression analysis modeling. The database was used to substantiate a set of nozzle performance data from wind tunnel testing and computational fluid dynamic analyses. Findings from initial flight research at Mach 0.9 and 1.2 are presented in this paper. The results show that vector efficiency is strongly influenced by power setting. A significant discrepancy in nozzle performance has been discovered between predicted and measured results during vectoring.

Transmission of tularemia from a water source by transstadial maintenance in a mosquito vector

NASA Astrophysics Data System (ADS)

Bäckman, Stina; Näslund, Jonas; Forsman, Mats; Thelaus, Johanna

2015-01-01

Mosquitoes are thought to function as mechanical vectors of Francisella tularensis subspecies holarctica (F. t. holarctica) causing tularemia in humans. We investigated the clinical relevance of transstadially maintained F. t. holarctica in mosquitoes. Aedes egypti larvae exposed to a fully virulent F. t. holarctica strain for 24 hours, were allowed to develop into adults when they were individually homogenized. Approximately 24% of the homogenates tested positive for F. t. DNA in PCR. Mice injected with the mosquito homogenates acquired tularemia within 5 days. This novel finding demonstrates the possibility of transmission of bacteria by adult mosquitoes having acquired the pathogen from their aquatic larval habitats.

Prospects for developing odour baits to control Glossina fuscipes spp., the major vector of human African trypanosomiasis.

PubMed

Omolo, Maurice O; Hassanali, Ahmed; Mpiana, Serge; Esterhuizen, Johan; Lindh, Jenny; Lehane, Mike J; Solano, Philippe; Rayaisse, Jean Baptiste; Vale, Glyn A; Torr, Steve J; Tirados, Inaki

2009-01-01

We are attempting to develop cost-effective control methods for the important vector of sleeping sickness, Glossina fuscipes spp. Responses of the tsetse flies Glossina fuscipes fuscipes (in Kenya) and G. f. quanzensis (in Democratic Republic of Congo) to natural host odours are reported. Arrangements of electric nets were used to assess the effect of cattle-, human- and pig-odour on (1) the numbers of tsetse attracted to the odour source and (2) the proportion of flies that landed on a black target (1x1 m). In addition responses to monitor lizard (Varanus niloticus) were assessed in Kenya. The effects of all four odours on the proportion of tsetse that entered a biconical trap were also determined. Sources of natural host odour were produced by placing live hosts in a tent or metal hut (volumes approximately 16 m(3)) from which the air was exhausted at approximately 2000 L/min. Odours from cattle, pigs and humans had no significant effect on attraction of G. f. fuscipes but lizard odour doubled the catch (P<0.05). Similarly, mammalian odours had no significant effect on landing or trap entry whereas lizard odour increased these responses significantly: landing responses increased significantly by 22% for males and 10% for females; the increase in trap efficiency was relatively slight (5-10%) and not always significant. For G. f. quanzensis, only pig odour had a consistent effect, doubling the catch of females attracted to the source and increasing the landing response for females by approximately 15%. Dispensing CO(2) at doses equivalent to natural hosts suggested that the response of G. f. fuscipes to lizard odour was not due to CO(2). For G. f. quanzensis, pig odour and CO(2) attracted similar numbers of tsetse, but CO(2) had no material effect on the landing response. The results suggest that identifying kairomones present in lizard odour for G. f. fuscipes and pig odour for G. f. quanzensis may improve the performance of targets for controlling these species.

Explosive synchronization coexists with classical synchronization in the Kuramoto model

DOE Office of Scientific and Technical Information (OSTI.GOV)

Danziger, Michael M., E-mail: michael.danziger@biu.ac.il; Havlin, Shlomo; Moskalenko, Olga I.

2016-06-15

Explosive synchronization has recently been reported in a system of adaptively coupled Kuramoto oscillators, without any conditions on the frequency or degree of the nodes. Here, we find that, in fact, the explosive phase coexists with the standard phase of the Kuramoto oscillators. We determine this by extending the mean-field theory of adaptively coupled oscillators with full coupling to the case with partial coupling of a fraction f. This analysis shows that a metastable region exists for all finite values of f > 0, and therefore explosive synchronization is expected for any perturbation of adaptively coupling added to the standard Kuramoto model.more » We verify this theory with GPU-accelerated simulations on very large networks (N ∼ 10{sup 6}) and find that, in fact, an explosive transition with hysteresis is observed for all finite couplings. By demonstrating that explosive transitions coexist with standard transitions in the limit of f → 0, we show that this behavior is far more likely to occur naturally than was previously believed.« less

Transient expression of the influenza A virus PB1-F2 protein using a plum pox virus-based vector in Nicotiana benthamiana.

PubMed

Kamencayová, M; Košík, I; Hunková, J; Subr, Z W

2014-01-01

PB1-F2 protein of influenza A virus (IAV) was cloned in a plum pox virus (PPV) genome-based vector and attempts to express it in biolistically transfected Nicotiana benthamiana plants were performed. The vector-insert construct replicated in infected plants properly and was stable during repeated passage by mechanical inoculation, as demonstrated by disease symptoms and immunoblot detection of PPV capsid protein, while PB1-F2-specific band was more faint. We showed that it was due its low solubility. Modification of sample preparation (denaturation/solubilization preceding the centrifugation of cell debris) led to substantial signal enhancement. Maximal level of PB1-F2 expression in plants was observed 12 days post inoculation (dpi). Only 1% SDS properly solubilized the protein, other detergents were much less efficient. Solubilization with 8M urea released approximately 50% of PB1-F2 from the plant tissues, thus the treatment with this removable chaotropic agent may be a good starting point for the purification of the protein for eventual functional studies in the future.

Revisiting simplified dark matter models in terms of AMS-02 and Fermi-LAT

NASA Astrophysics Data System (ADS)

Li, Tong

2018-01-01

We perform an analysis of the simplified dark matter models in the light of cosmic ray observables by AMS-02 and Fermi-LAT. We assume fermion, scalar or vector dark matter particle with a leptophobic spin-0 mediator that couples only to Standard Model quarks and dark matter via scalar and/or pseudo-scalar bilinear. The propagation and injection parameters of cosmic rays are determined by the observed fluxes of nuclei from AMS-02. We find that the AMS-02 observations are consistent with the dark matter framework within the uncertainties. The AMS-02 antiproton data prefer 30 (50) GeV - 5 TeV dark matter mass and require an effective annihilation cross section in the region of 4 × 10-27 (7 × 10-27) - 4 × 10-24 cm3/s for the simplified fermion (scalar and vector) dark matter models. The cross sections below 2 × 10-26 cm3/s can evade the constraint from Fermi-LAT dwarf galaxies for about 100 GeV dark matter mass.

Vector- and tensor-meson production and the Pomeron-f identity hypothesis

DOE Office of Scientific and Technical Information (OSTI.GOV)

Jones, S.T.

Within the context of a model introduced some time ago, the differential and total production cross sections for vector and tensor mesons are shown to be compatible with the hypothesis that the Pomeron and f are a single Regge trajectory. The model incorporates both cylinder and flavoring renormalizations of the Pomeron-f trajectory. The processes K/sup +- /p..-->..K/sup */(892)/sup +- /p, K/sup +- /p ..-->..K/sub 2//sup */(1430)/sup +- /p, and ..pi../sup +- /p..-->..A/sub 2/(1320)/sup +- /p are analyzed in some detail.

Symplectic Quantization of a Vector-Tensor Gauge Theory with Topological Coupling

NASA Astrophysics Data System (ADS)

Barcelos-Neto, J.; Silva, M. B. D.

We use the symplectic formalism to quantize a gauge theory where vectors and tensors fields are coupled in a topological way. This is an example of reducible theory and a procedure like of ghosts-of-ghosts of the BFV method is applied but in terms of Lagrange multipliers. Our final results are in agreement with the ones found in the literature by using the Dirac method.

Integrated Control Using the SOFFT Control Structure

NASA Technical Reports Server (NTRS)

Halyo, Nesim

1996-01-01

The need for integrated/constrained control systems has become clearer as advanced aircraft introduced new coupled subsystems such as new propulsion subsystems with thrust vectoring and new aerodynamic designs. In this study, we develop an integrated control design methodology which accomodates constraints among subsystem variables while using the Stochastic Optimal Feedforward/Feedback Control Technique (SOFFT) thus maintaining all the advantages of the SOFFT approach. The Integrated SOFFT Control methodology uses a centralized feedforward control and a constrained feedback control law. The control thus takes advantage of the known coupling among the subsystems while maintaining the identity of subsystems for validation purposes and the simplicity of the feedback law to understand the system response in complicated nonlinear scenarios. The Variable-Gain Output Feedback Control methodology (including constant gain output feedback) is extended to accommodate equality constraints. A gain computation algorithm is developed. The designer can set the cross-gains between two variables or subsystems to zero or another value and optimize the remaining gains subject to the constraint. An integrated control law is designed for a modified F-15 SMTD aircraft model with coupled airframe and propulsion subsystems using the Integrated SOFFT Control methodology to produce a set of desired flying qualities.

Production of heavy sterile neutrinos from vector boson decay at electroweak temperatures

DOE PAGES

Lello, Louis; Boyanovsky, Daniel; Pisarski, Robert D.

2017-02-22

Here, in the standard model extended with a seesaw mass matrix, we study the production of sterile neutrinos from the decay of vector bosons at temperatures near the masses of the electroweak bosons. We derive a general quantum kinetic equation for the production of sterile neutrinos and their effective mixing angles, which is applicable over a wide range of temperature, to all orders in interactions of the standard model and to leading order in a small mixing angle for the neutrinos. We emphasize the relation between the production rate and Landau damping at one-loop order and show that production rates and effective mixing angles depend sensitively upon the neutrino’s helicity. Sterile neutrinos with positive helicity interact more weakly with the medium than those with negative helicity, and their effective mixing angle is not modified significantly. Negative helicity states couple more strongly to the vector bosons, but their mixing angle is strongly suppressed by the medium. Consequently, if the mass of the sterile neutrino is ≲ 8.35 MeV , there are fewer states with negative helicity produced than those with positive helicity. There is an Mikheyev-Smirnov-Wolfenstein-type resonance in the absence of lepton asymmetry, but due to screening by the damping rate, the production rate is not enhanced. Sterile neutrinos with negative helicity freeze out at Tmore » $$-\\atop{f}$$ ≃ 5 GeV , whereas positive helicity neutrinos freeze out at T$$+\\atop{f}$$≃ 8 GeV , with both distributions far from thermal. As the temperature decreases, due to competition between a decreasing production rate and an increasing mixing angle, the distribution function for states with negative helicity is broader in momentum and hotter than that for those with positive helicity. Sterile neutrinos produced via vector boson decay do not satisfy the abundance, lifetime, and cosmological constraints to be the sole dark matter component in the Universe. Massive sterile neutrinos produced via vector boson decay might solve the 7Li problem, albeit at the very edge of the possible parameter space. A heavy sterile neutrino with a mass of a few MeV could decay into light sterile neutrinos, of a few keV in mass, that contribute to warm dark matter. In conclusion, we argue that heavy sterile neutrinos with lifetime ≤1/H 0 reach local thermodynamic equilibrium.« less

Weak production of strange particles and η mesons off the nucleon

DOE Office of Scientific and Technical Information (OSTI.GOV)

Alam, M. Rafi; Athar, M. Sajjad; Simo, I. Ruiz

2015-10-15

The strange particle production induced by (anti)neutrino off nucleon has been studied for |ΔS| = 0 and |ΔS| = 1 channels. The reactions those we have considered are for the production of single kaon/antikaon, eta and associated particle production processes. We have developed a microscopical model based on the SU(3) chiral Lagrangian. The basic parameters of the model are f{sub π}, the pion decay constant, Cabibbo angle, the proton and neutron magnetic moments and the axial vector coupling constants for the baryons octet. For antikaon production we have also included Σ*(1385) resonance and for eta production S{sub 11}(1535) and S{submore » 11}(1650) resonances are included.« less

New Limits on Bosonic Dark Matter, Solar Axions, Pauli Exclusion Principle Violation, and Electron Decay from the Majorana Demonstrator

DOE PAGES

Abgrall, N.; Arnquist, I. J.; Avignone, F. T.; ...

2017-04-21

Here, we present new limits on exotic keV-scale physics based on 478 kg d of Majorana Demonstrator commissioning data. Constraints at the 90% confidence level are derived on bosonic dark matter (DM) and solar axion couplings, Pauli exclusion principle violating (PEPV) decay, and electron decay using monoenergetic peak signal limits above our background. We set our most stringent DM constraints for 11.8 keV mass particles, limiting g A e < 4.5 × 10 -13 for pseudoscalars and ( α ' / α ) < 9.7 × 10 -28 for vectors. We also report a 14.4 keV solar axion coupling limit of gmore » $$eff\\atop{AN}$$ × g A e < 3.8 × 10 -17 , a 1/2 β 2 < 8.5 × 10 - 48 limit on the strength of PEPV electron transitions, and a lower limit on the electron lifetime of τ e > 1.2 × 1 0 24 yr for e - → invisible.« less

New Limits on Bosonic Dark Matter, Solar Axions, Pauli Exclusion Principle Violation, and Electron Decay from the Majorana Demonstrator

NASA Astrophysics Data System (ADS)

Abgrall, N.; Arnquist, I. J.; Avignone, F. T.; Barabash, A. S.; Bertrand, F. E.; Bradley, A. W.; Brudanin, V.; Busch, M.; Buuck, M.; Caldwell, T. S.; Chan, Y.-D.; Christofferson, C. D.; Chu, P.-H.; Cuesta, C.; Detwiler, J. A.; Dunagan, C.; Efremenko, Yu.; Ejiri, H.; Elliott, S. R.; Gilliss, T.; Giovanetti, G. K.; Goett, J.; Green, M. P.; Gruszko, J.; Guinn, I. S.; Guiseppe, V. E.; Haufe, C. R. S.; Henning, R.; Hoppe, E. W.; Howard, S.; Howe, M. A.; Jasinski, B. R.; Keeter, K. J.; Kidd, M. F.; Konovalov, S. I.; Kouzes, R. T.; Lopez, A. M.; MacMullin, J.; Martin, R. D.; Massarczyk, R.; Meijer, S. J.; Mertens, S.; O'Shaughnessy, C.; Poon, A. W. P.; Radford, D. C.; Rager, J.; Reine, A. L.; Rielage, K.; Robertson, R. G. H.; Shanks, B.; Shirchenko, M.; Suriano, A. M.; Tedeschi, D.; Trimble, J. E.; Varner, R. L.; Vasilyev, S.; Vetter, K.; Vorren, K.; White, B. R.; Wilkerson, J. F.; Wiseman, C.; Xu, W.; Yakushev, E.; Yu, C.-H.; Yumatov, V.; Zhitnikov, I.; Zhu, B. X.; MAJORANA Collaboration

2017-04-01

We present new limits on exotic keV-scale physics based on 478 kg d of Majorana Demonstrator commissioning data. Constraints at the 90% confidence level are derived on bosonic dark matter (DM) and solar axion couplings, Pauli exclusion principle violating (PEPV) decay, and electron decay using monoenergetic peak signal limits above our background. Our most stringent DM constraints are set for 11.8 keV mass particles, limiting gA e<4.5 ×10-13 for pseudoscalars and (α'/α )<9.7 ×10-28 for vectors. We also report a 14.4 keV solar axion coupling limit of gAN eff×gA e<3.8 ×10-17, a 1/2 β2<8.5 ×10-48 limit on the strength of PEPV electron transitions, and a lower limit on the electron lifetime of τe>1.2 ×1 024 yr for e-→ invisible.

Direct and converse theorems in problems of approximation by vectors of finite degree

DOE Office of Scientific and Technical Information (OSTI.GOV)

Radzievski, G V

1998-04-30

Let A be a linear operator in a complex Banach space X with domain D(A) and a non-empty resolvent set. An element g element of D{sub {infinity}}(A):= intersection{sub j=0,1,...}D(A{sup j}) is called a vector of degree at most {zeta}(>0) with respect to A if ||A{sup j}g||{sub X}{<=}c(g){zeta}{sup j}, j=0,1,.... The set of vectors of degree at most {zeta} is denoted by G{sub {zeta}}(A). The quantity E{sub {zeta}}(f,A){sub X}=inf{sub gelement} {sub of{sub G}{sub {zeta}}}{sub (A)}||f-g||{sub X} is introduced and estimated in terms of the K-functional K({zeta}{sup -r},f;X,D(A{sup r}))=inf{sub gelementof} {sub D(A{sup r})}(||f-g||{sub X}+{zeta}{sup -r}||A{sup r}f||{sub X}) (the direct theorem). An estimatemore » of this K-functional in terms of E{sub {zeta}}(f,A){sub X} and ||f||{sub x} is established (the converse theorem). Using the estimates obtained, necessary and sufficient conditions for the following properties are found in terms of E{sub {zeta}}(f,A){sub X}: 1) f element of D{sub {infinity}}(A); 2) the series e{sup zA}f:={sigma}{sub r=0}{sup {infinity}}(z{sup r}A{sup r}f)/(r{exclamation_point}) converges in some disc; 3) the series e{sup zA}f converges in the entire complex plane. The growth order and the type of the entire function e{sup zA}f are calculated in terms of E{sub {zeta}}(f,A){sub X}.« less

ENSO Bred Vectors in Coupled Ocean-Atmosphere General Circulation Models

NASA Technical Reports Server (NTRS)

Yang, S. C.; Cai, Ming; Kalnay, E.; Rienecker, M.; Yuan, G.; Toth, ZA.

2004-01-01

The breeding method has been implemented in the NASA Seasonal-to-Interannual Prediction Project (NSIPP) Coupled General Circulation Model (CGCM) with the goal of improving operational seasonal to interannual climate predictions through ensemble forecasting and data assimilation. The coupled instability as cap'tured by the breeding method is the first attempt to isolate the evolving ENSO instability and its corresponding global atmospheric response in a fully coupled ocean-atmosphere GCM. Our results show that the growth rate of the coupled bred vectors (BV) peaks at about 3 months before a background ENSO event. The dominant growing BV modes are reminiscent of the background ENSO anomalies and show a strong tropical response with wind/SST/thermocline interrelated in a manner similar to the background ENSO mode. They exhibit larger amplitudes in the eastern tropical Pacific, reflecting the natural dynamical sensitivity associated with the presence of the shallow thermocline. Moreover, the extratropical perturbations associated with these coupled BV modes reveal the variations related to the atmospheric teleconnection patterns associated with background ENSO variability, e.g. over the North Pacific and North America. A similar experiment was carried out with the NCEP/CFS03 CGCM. Comparisons between bred vectors from the NSIPP CGCM and NCEP/CFS03 CGCM demonstrate the robustness of the results. Our results strongly suggest that the breeding method can serve as a natural filter to identify the slowly varying, coupled instabilities in a coupled GCM, which can be used to construct ensemble perturbations for ensemble forecasts and to estimate the coupled background error covariance for coupled data assimilation.

Amblyomma americanum as a Bridging Vector for Human Infection with Francisella tularensis

PubMed Central

2015-01-01

The γ-proteobacterium Francisella tularensis causes seasonal tick-transmitted tularemia outbreaks in natural rabbit hosts and incidental infections in humans in the south-central United States. Although Dermacentor variabilis is considered a primary vector for F. tularensis, Amblyomma americanum is the most abundant tick species in this endemic region. A systematic study of F. tularensis colonization of A. americanum was undertaken to better understand its potential to serve as an overwintering reservoir for F. tularensis and as a bridging vector for human infections. Colony-reared A. americanum were artificially fed F. tularensis subspecies holarctica strain LVS via glass capillaries and colonization levels determined. Capillary-fed larva and nymph were initially infected with 104 CFU/tick which declined prior to molting for both stages, but rebounded post-molting in nymphs and persisted in 53% at 103 to 108 CFU/nymph at 168 days post-capillary feeding (longest sampling time in the study). In contrast, only 18% of adults molted from colonized nymphs maintained LVS colonization at 101 to 105 CFU/adult at 168 days post-capillary feeding (longest sampling time). For adults, LVS initially colonized the gut and disseminated to salivary glands by 24 h and had an ID50 of <5CFU in mice. Francisella tularensis infected the ovaries of gravid females, but transmission to eggs was infrequent and transovarial transmission to hatched larvae was not observed. The prolonged persistence of F. tularensis in A. americanum nymphs supports A. americanum as an overwintering reservoir for F. tularensis from which seasonal epizootics may originate; however, although the rapid dissemination of F. tularensis from gut to salivary glands in adults A. americanum is compatible with intermittent feeding adult males acting as bridging vectors for incidental F. tularensis infections of humans, acquisition of F. tularensis by adults may be unlikely based on adult feeding preference for larger mammals which are not involved in maintenance of sylvatic tularemia. PMID:26121137

On scalar and vector fields coupled to the energy-momentum tensor

NASA Astrophysics Data System (ADS)

Jiménez, Jose Beltrán; Cembranos, Jose A. R.; Sánchez Velázquez, Jose M.

2018-05-01

We consider theories for scalar and vector fields coupled to the energy-momentum tensor. Since these fields also carry a non-trivial energy-momentum tensor, the coupling prescription generates self-interactions. In analogy with gravity theories, we build the action by means of an iterative process that leads to an infinite series, which can be resumed as the solution of a set of differential equations. We show that, in some particular cases, the equations become algebraic and that is also possible to find solutions in the form of polynomials. We briefly review the case of the scalar field that has already been studied in the literature and extend the analysis to the case of derivative (disformal) couplings. We then explore theories with vector fields, distinguishing between gauge-and non-gauge-invariant couplings. Interactions with matter are also considered, taking a scalar field as a proxy for the matter sector. We also discuss the ambiguity introduced by superpotential (boundary) terms in the definition of the energy-momentum tensor and use them to show that it is also possible to generate Galileon-like interactions with this procedure. We finally use collider and astrophysical observations to set constraints on the dimensionful coupling which characterises the phenomenology of these models.

Nucleon and Delta axial-vector couplings in 1/N{sub c}-Baryon Chiral Perturbation Theory

DOE Office of Scientific and Technical Information (OSTI.GOV)

Goity, Jose Luis; Calle Cordon, Alvaro

In this contribution, baryon axial-vector couplings are studied in the framework of the combined 1/N{sub c} and chiral expansions. This framework is implemented on the basis of the emergent spin-flavor symmetry in baryons at large N{sub c} and HBChPT, and linking both expansions ({xi}-expansion), where 1/N{sub c} is taken to be a quantity order p. The study is carried out including one-loop contributions, which corresponds to order xi to the third for baryon masses and order {xi} square for the axial couplings.

Limits on the Higgs boson lifetime and width from its decay to four charged leptons

NASA Astrophysics Data System (ADS)

Khachatryan, V.; Sirunyan, A. M.; Tumasyan, A.; Adam, W.; Asilar, E.; Bergauer, T.; Brandstetter, J.; Brondolin, E.; Dragicevic, M.; Erö, J.; Flechl, M.; Friedl, M.; Frühwirth, R.; Ghete, V. M.; Hartl, C.; Hörmann, N.; Hrubec, J.; Jeitler, M.; Knünz, V.; König, A.; Krammer, M.; Krätschmer, I.; Liko, D.; Matsushita, T.; Mikulec, I.; Rabady, D.; Rahbaran, B.; Rohringer, H.; Schieck, J.; Schöfbeck, R.; Strauss, J.; Treberer-Treberspurg, W.; Waltenberger, W.; Wulz, C.-E.; Mossolov, V.; Shumeiko, N.; Suarez Gonzalez, J.; Alderweireldt, S.; Cornelis, T.; de Wolf, E. A.; Janssen, X.; Knutsson, A.; Lauwers, J.; Luyckx, S.; Ochesanu, S.; Rougny, R.; van de Klundert, M.; van Haevermaet, H.; van Mechelen, P.; van Remortel, N.; van Spilbeeck, A.; Abu Zeid, S.; Blekman, F.; D'Hondt, J.; Daci, N.; de Bruyn, I.; Deroover, K.; Heracleous, N.; Keaveney, J.; Lowette, S.; Moreels, L.; Olbrechts, A.; Python, Q.; Strom, D.; Tavernier, S.; van Doninck, W.; van Mulders, P.; van Onsem, G. P.; van Parijs, I.; Barria, P.; Caillol, C.; Clerbaux, B.; de Lentdecker, G.; Delannoy, H.; Fasanella, G.; Favart, L.; Gay, A. P. R.; Grebenyuk, A.; Lenzi, T.; Léonard, A.; Maerschalk, T.; Marinov, A.; Perniè, L.; Randle-Conde, A.; Reis, T.; Seva, T.; Vander Velde, C.; Vanlaer, P.; Yonamine, R.; Zenoni, F.; Zhang, F.; Beernaert, K.; Benucci, L.; Cimmino, A.; Crucy, S.; Dobur, D.; Fagot, A.; Garcia, G.; Gul, M.; McCartin, J.; Ocampo Rios, A. A.; Poyraz, D.; Ryckbosch, D.; Salva, S.; Sigamani, M.; Strobbe, N.; Tytgat, M.; van Driessche, W.; Yazgan, E.; Zaganidis, N.; Basegmez, S.; Beluffi, C.; Bondu, O.; Brochet, S.; Bruno, G.; Castello, R.; Caudron, A.; Ceard, L.; da Silveira, G. G.; Delaere, C.; Favart, D.; Forthomme, L.; Giammanco, A.; Hollar, J.; Jafari, A.; Jez, P.; Komm, M.; Lemaitre, V.; Mertens, A.; Nuttens, C.; Perrini, L.; Pin, A.; Piotrzkowski, K.; Popov, A.; Quertenmont, L.; Selvaggi, M.; Vidal Marono, M.; Beliy, N.; Hammad, G. H.; Aldá Júnior, W. L.; Alves, G. A.; Brito, L.; Correa Martins Junior, M.; Hamer, M.; Hensel, C.; Mora Herrera, C.; Moraes, A.; Pol, M. E.; Rebello Teles, P.; Belchior Batista Das Chagas, E.; Carvalho, W.; Chinellato, J.; Custódio, A.; da Costa, E. M.; de Jesus Damiao, D.; de Oliveira Martins, C.; Fonseca de Souza, S.; Huertas Guativa, L. M.; Malbouisson, H.; Matos Figueiredo, D.; Mundim, L.; Nogima, H.; Prado da Silva, W. L.; Santoro, A.; Sznajder, A.; Tonelli Manganote, E. J.; Vilela Pereira, A.; Ahuja, S.; Bernardes, C. A.; de Souza Santos, A.; Dogra, S.; Tomei, T. R. Fernandez Perez; Gregores, E. M.; Mercadante, P. G.; Moon, C. S.; Novaes, S. F.; Padula, Sandra S.; Romero Abad, D.; Ruiz Vargas, J. C.; Aleksandrov, A.; Genchev, V.; Hadjiiska, R.; Iaydjiev, P.; Piperov, S.; Rodozov, M.; Stoykova, S.; Sultanov, G.; Vutova, M.; Dimitrov, A.; Glushkov, I.; Litov, L.; Pavlov, B.; Petkov, P.; Ahmad, M.; Bian, J. G.; Chen, G. M.; Chen, H. S.; Chen, M.; Cheng, T.; Du, R.; Jiang, C. H.; Plestina, R.; Romeo, F.; Shaheen, S. M.; Tao, J.; Wang, C.; Wang, Z.; Zhang, H.; Asawatangtrakuldee, C.; Ban, Y.; Li, Q.; Liu, S.; Mao, Y.; Qian, S. J.; Wang, D.; Xu, Z.; Zou, W.; Avila, C.; Cabrera, A.; Chaparro Sierra, L. F.; Florez, C.; Gomez, J. P.; Gomez Moreno, B.; Sanabria, J. C.; Godinovic, N.; Lelas, D.; Polic, D.; Puljak, I.; Ribeiro Cipriano, P. M.; Antunovic, Z.; Kovac, M.; Brigljevic, V.; Kadija, K.; Luetic, J.; Micanovic, S.; Sudic, L.; Attikis, A.; Mavromanolakis, G.; Mousa, J.; Nicolaou, C.; Ptochos, F.; Razis, P. A.; Rykaczewski, H.; Bodlak, M.; Finger, M.; Finger, M.; El-Khateeb, E.; Elkafrawy, T.; Mohamed, A.; Salama, E.; Calpas, B.; Kadastik, M.; Murumaa, M.; Raidal, M.; Tiko, A.; Veelken, C.; Eerola, P.; Pekkanen, J.; Voutilainen, M.; Härkönen, J.; Karimäki, V.; Kinnunen, R.; Lampén, T.; Lassila-Perini, K.; Lehti, S.; Lindén, T.; Luukka, P.; Mäenpää, T.; Peltola, T.; Tuominen, E.; Tuominiemi, J.; Tuovinen, E.; Wendland, L.; Talvitie, J.; Tuuva, T.; Besancon, M.; Couderc, F.; Dejardin, M.; Denegri, D.; Fabbro, B.; Faure, J. L.; Favaro, C.; Ferri, F.; Ganjour, S.; Givernaud, A.; Gras, P.; Hamel de Monchenault, G.; Jarry, P.; Locci, E.; Machet, M.; Malcles, J.; Rander, J.; Rosowsky, A.; Titov, M.; Zghiche, A.; Antropov, I.; Baffioni, S.; Beaudette, F.; Busson, P.; Cadamuro, L.; Chapon, E.; Charlot, C.; Dahms, T.; Davignon, O.; Filipovic, N.; Florent, A.; Granier de Cassagnac, R.; Lisniak, S.; Mastrolorenzo, L.; Miné, P.; Naranjo, I. N.; Nguyen, M.; Ochando, C.; Ortona, G.; Paganini, P.; Regnard, S.; Salerno, R.; Sauvan, J. B.; Sirois, Y.; Strebler, T.; Yilmaz, Y.; Zabi, A.; Agram, J.-L.; Andrea, J.; Aubin, A.; Bloch, D.; Brom, J.-M.; Buttignol, M.; Chabert, E. C.; Chanon, N.; Collard, C.; Conte, E.; Coubez, X.; Fontaine, J.-C.; Gelé, D.; Goerlach, U.; Goetzmann, C.; Le Bihan, A.-C.; Merlin, J. A.; Skovpen, K.; van Hove, P.; Gadrat, S.; Beauceron, S.; Bernet, C.; Boudoul, G.; Bouvier, E.; Carrillo Montoya, C. A.; Chasserat, J.; Chierici, R.; Contardo, D.; Courbon, B.; Depasse, P.; El Mamouni, H.; Fan, J.; Fay, J.; Gascon, S.; Gouzevitch, M.; Ille, B.; Lagarde, F.; Laktineh, I. B.; Lethuillier, M.; Mirabito, L.; Pequegnot, A. L.; Perries, S.; Ruiz Alvarez, J. D.; Sabes, D.; Sgandurra, L.; Sordini, V.; Vander Donckt, M.; Verdier, P.; Viret, S.; Xiao, H.; Toriashvili, T.; Tsamalaidze, Z.; Autermann, C.; Beranek, S.; Edelhoff, M.; Feld, L.; Heister, A.; Kiesel, M. K.; Klein, K.; Lipinski, M.; Ostapchuk, A.; Preuten, M.; Raupach, F.; Schael, S.; Schulte, J. F.; Verlage, T.; Weber, H.; Wittmer, B.; Zhukov, V.; Ata, M.; Brodski, M.; Dietz-Laursonn, E.; Duchardt, D.; Endres, M.; Erdmann, M.; Erdweg, S.; Esch, T.; Fischer, R.; Güth, A.; Hebbeker, T.; Heidemann, C.; Hoepfner, K.; Klingebiel, D.; Knutzen, S.; Kreuzer, P.; Merschmeyer, M.; Meyer, A.; Millet, P.; Olschewski, M.; Padeken, K.; Papacz, P.; Pook, T.; Radziej, M.; Reithler, H.; Rieger, M.; Scheuch, F.; Sonnenschein, L.; Teyssier, D.; Thüer, S.; Cherepanov, V.; Erdogan, Y.; Flügge, G.; Geenen, H.; Geisler, M.; Hoehle, F.; Kargoll, B.; Kress, T.; Kuessel, Y.; Künsken, A.; Lingemann, J.; Nehrkorn, A.; Nowack, A.; Nugent, I. M.; Pistone, C.; Pooth, O.; Stahl, A.; Aldaya Martin, M.; Asin, I.; Bartosik, N.; Behnke, O.; Behrens, U.; Bell, A. J.; Borras, K.; Burgmeier, A.; Cakir, A.; Calligaris, L.; Campbell, A.; Choudhury, S.; Costanza, F.; Diez Pardos, C.; Dolinska, G.; Dooling, S.; Dorland, T.; Eckerlin, G.; Eckstein, D.; Eichhorn, T.; Flucke, G.; Gallo, E.; Garay Garcia, J.; Geiser, A.; Gizhko, A.; Gunnellini, P.; Hauk, J.; Hempel, M.; Jung, H.; Kalogeropoulos, A.; Karacheban, O.; Kasemann, M.; Katsas, P.; Kieseler, J.; Kleinwort, C.; Korol, I.; Lange, W.; Leonard, J.; Lipka, K.; Lobanov, A.; Lohmann, W.; Mankel, R.; Marfin, I.; Melzer-Pellmann, I.-A.; Meyer, A. B.; Mittag, G.; Mnich, J.; Mussgiller, A.; Naumann-Emme, S.; Nayak, A.; Ntomari, E.; Perrey, H.; Pitzl, D.; Placakyte, R.; Raspereza, A.; Roland, B.; Sahin, M. Ö.; Saxena, P.; Schoerner-Sadenius, T.; Schröder, M.; Seitz, C.; Spannagel, S.; Trippkewitz, K. D.; Walsh, R.; Wissing, C.; Blobel, V.; Centis Vignali, M.; Draeger, A. R.; Erfle, J.; Garutti, E.; Goebel, K.; Gonzalez, D.; Görner, M.; Haller, J.; Hoffmann, M.; Höing, R. S.; Junkes, A.; Klanner, R.; Kogler, R.; Lapsien, T.; Lenz, T.; Marchesini, I.; Marconi, D.; Nowatschin, D.; Ott, J.; Pantaleo, F.; Peiffer, T.; Perieanu, A.; Pietsch, N.; Poehlsen, J.; Rathjens, D.; Sander, C.; Schettler, H.; Schleper, P.; Schlieckau, E.; Schmidt, A.; Schwandt, J.; Seidel, M.; Sola, V.; Stadie, H.; Steinbrück, G.; Tholen, H.; Troendle, D.; Usai, E.; Vanelderen, L.; Vanhoefer, A.; Akbiyik, M.; Barth, C.; Baus, C.; Berger, J.; Böser, C.; Butz, E.; Chwalek, T.; Colombo, F.; de Boer, W.; Descroix, A.; Dierlamm, A.; Fink, S.; Frensch, F.; Giffels, M.; Gilbert, A.; Hartmann, F.; Heindl, S. M.; Husemann, U.; Katkov, I.; Kornmayer, A.; Lobelle Pardo, P.; Maier, B.; Mildner, H.; Mozer, M. U.; Müller, T.; Müller, Th.; Plagge, M.; Quast, G.; Rabbertz, K.; Röcker, S.; Roscher, F.; Simonis, H. J.; Stober, F. M.; Ulrich, R.; Wagner-Kuhr, J.; Wayand, S.; Weber, M.; Weiler, T.; Wöhrmann, C.; Wolf, R.; Anagnostou, G.; Daskalakis, G.; Geralis, T.; Giakoumopoulou, V. A.; Kyriakis, A.; Loukas, D.; Psallidas, A.; Topsis-Giotis, I.; Agapitos, A.; Kesisoglou, S.; Panagiotou, A.; Saoulidou, N.; Tziaferi, E.; Evangelou, I.; Flouris, G.; Foudas, C.; Kokkas, P.; Loukas, N.; Manthos, N.; Papadopoulos, I.; Paradas, E.; Strologas, J.; Bencze, G.; Hajdu, C.; Hazi, A.; Hidas, P.; Horvath, D.; Sikler, F.; Veszpremi, V.; Vesztergombi, G.; Zsigmond, A. J.; Beni, N.; Czellar, S.; Karancsi, J.; Molnar, J.; Szillasi, Z.; Bartók, M.; Makovec, A.; Raics, P.; Trocsanyi, Z. L.; Ujvari, B.; Mal, P.; Mandal, K.; Sahoo, N.; Swain, S. K.; Bansal, S.; Beri, S. B.; Bhatnagar, V.; Chawla, R.; Gupta, R.; Bhawandeep, U.; Kalsi, A. K.; Kaur, A.; Kaur, M.; Kumar, R.; Mehta, A.; Mittal, M.; Singh, J. B.; Walia, G.; Kumar, Ashok; Kumar, Arun; Bhardwaj, A.; Choudhary, B. C.; Garg, R. B.; Kumar, A.; Malhotra, S.; Naimuddin, M.; Nishu, N.; Ranjan, K.; Sharma, R.; Sharma, V.; Banerjee, S.; Bhattacharya, S.; Chatterjee, K.; Dey, S.; Dutta, S.; Jain, Sa.; Majumdar, N.; Modak, A.; Mondal, K.; Mukherjee, S.; Mukhopadhyay, S.; Roy, A.; Roy, D.; Roy Chowdhury, S.; Sarkar, S.; Sharan, M.; Abdulsalam, A.; Chudasama, R.; Dutta, D.; Jha, V.; Kumar, V.; Mohanty, A. K.; Pant, L. M.; Shukla, P.; Topkar, A.; Aziz, T.; Banerjee, S.; Bhowmik, S.; Chatterjee, R. M.; Dewanjee, R. K.; Dugad, S.; Ganguly, S.; Ghosh, S.; Guchait, M.; Gurtu, A.; Kole, G.; Kumar, S.; Mahakud, B.; Maity, M.; Majumder, G.; Mazumdar, K.; Mitra, S.; Mohanty, G. B.; Parida, B.; Sarkar, T.; Sudhakar, K.; Sur, N.; Sutar, B.; Wickramage, N.; Chauhan, S.; Dube, S.; Sharma, S.; Bakhshiansohi, H.; Behnamian, H.; Etesami, S. M.; Fahim, A.; Goldouzian, R.; Khakzad, M.; Mohammadi Najafabadi, M.; Naseri, M.; Paktinat Mehdiabadi, S.; Rezaei Hosseinabadi, F.; Safarzadeh, B.; Zeinali, M.; Felcini, M.; Grunewald, M.; Abbrescia, M.; Calabria, C.; Caputo, C.; Chhibra, S. S.; Colaleo, A.; Creanza, D.; Cristella, L.; de Filippis, N.; de Palma, M.; Fiore, L.; Iaselli, G.; Maggi, G.; Maggi, M.; Miniello, G.; My, S.; Nuzzo, S.; Pompili, A.; Pugliese, G.; Radogna, R.; Ranieri, A.; Selvaggi, G.; Silvestris, L.; Venditti, R.; Verwilligen, P.; Abbiendi, G.; Battilana, C.; Benvenuti, A. C.; Bonacorsi, D.; Braibant-Giacomelli, S.; Brigliadori, L.; Campanini, R.; Capiluppi, P.; Castro, A.; Cavallo, F. R.; Codispoti, G.; Cuffiani, M.; Dallavalle, G. M.; Fabbri, F.; Fanfani, A.; Fasanella, D.; Giacomelli, P.; Grandi, C.; Guiducci, L.; Marcellini, S.; Masetti, G.; Montanari, A.; Navarria, F. L.; Perrotta, A.; Rossi, A. M.; Rovelli, T.; Siroli, G. P.; Tosi, N.; Travaglini, R.; Cappello, G.; Chiorboli, M.; Costa, S.; Giordano, F.; Potenza, R.; Tricomi, A.; Tuve, C.; Barbagli, G.; Ciulli, V.; Civinini, C.; D'Alessandro, R.; Focardi, E.; Gonzi, S.; Gori, V.; Lenzi, P.; Meschini, M.; Paoletti, S.; Sguazzoni, G.; Tropiano, A.; Viliani, L.; Benussi, L.; Bianco, S.; Fabbri, F.; Piccolo, D.; Calvelli, V.; Ferro, F.; Lo Vetere, M.; Monge, M. R.; Robutti, E.; Tosi, S.; Brianza, L.; Dinardo, M. E.; Fiorendi, S.; Gennai, S.; Gerosa, R.; Ghezzi, A.; Govoni, P.; Malvezzi, S.; Manzoni, R. A.; Marzocchi, B.; Menasce, D.; Moroni, L.; Paganoni, M.; Pedrini, D.; Ragazzi, S.; Redaelli, N.; Tabarelli de Fatis, T.; Buontempo, S.; Cavallo, N.; di Guida, S.; Esposito, M.; Fabozzi, F.; Iorio, A. O. M.; Lanza, G.; Lista, L.; Meola, S.; Merola, M.; Paolucci, P.; Sciacca, C.; Thyssen, F.; Azzi, P.; Bacchetta, N.; Benato, L.; Bisello, D.; Boletti, A.; Branca, A.; Carlin, R.; Carvalho Antunes de Oliveira, A.; Checchia, P.; Dall'Osso, M.; Dorigo, T.; Dosselli, U.; Gasparini, F.; Gasparini, U.; Gozzelino, A.; Kanishchev, K.; Lacaprara, S.; Margoni, M.; Meneguzzo, A. T.; Pazzini, J.; Pozzobon, N.; Ronchese, P.; Simonetto, F.; Torassa, E.; Tosi, M.; Zanetti, M.; Zotto, P.; Zucchetta, A.; Zumerle, G.; Braghieri, A.; Magnani, A.; Montagna, P.; Ratti, S. P.; Re, V.; Riccardi, C.; Salvini, P.; Vai, I.; Vitulo, P.; Alunni Solestizi, L.; Biasini, M.; Bilei, G. M.; Ciangottini, D.; Fanò, L.; Lariccia, P.; Mantovani, G.; Menichelli, M.; Saha, A.; Santocchia, A.; Spiezia, A.; Androsov, K.; Azzurri, P.; Bagliesi, G.; Bernardini, J.; Boccali, T.; Broccolo, G.; Castaldi, R.; Ciocci, M. A.; Dell'Orso, R.; Donato, S.; Fedi, G.; Foà, L.; Giassi, A.; Grippo, M. T.; Ligabue, F.; Lomtadze, T.; Martini, L.; Messineo, A.; Palla, F.; Rizzi, A.; Savoy-Navarro, A.; Serban, A. T.; Spagnolo, P.; Squillacioti, P.; Tenchini, R.; Tonelli, G.; Venturi, A.; Verdini, P. G.; Barone, L.; Cavallari, F.; D'Imperio, G.; Del Re, D.; Diemoz, M.; Gelli, S.; Jorda, C.; Longo, E.; Margaroli, F.; Meridiani, P.; Micheli, F.; Organtini, G.; Paramatti, R.; Preiato, F.; Rahatlou, S.; Rovelli, C.; Santanastasio, F.; Traczyk, P.; Amapane, N.; Arcidiacono, R.; Argiro, S.; Arneodo, M.; Bellan, R.; Biino, C.; Cartiglia, N.; Costa, M.; Covarelli, R.; Degano, A.; Demaria, N.; Finco, L.; Kiani, B.; Mariotti, C.; Maselli, S.; Migliore, E.; Monaco, V.; Monteil, E.; Musich, M.; Obertino, M. M.; Pacher, L.; Pastrone, N.; Pelliccioni, M.; Pinna Angioni, G. L.; Ravera, F.; Romero, A.; Ruspa, M.; Sacchi, R.; Solano, A.; Staiano, A.; Tamponi, U.; Belforte, S.; Candelise, V.; Casarsa, M.; Cossutti, F.; Della Ricca, G.; Gobbo, B.; La Licata, C.; Marone, M.; Schizzi, A.; Umer, T.; Zanetti, A.; Chang, S.; Kropivnitskaya, A.; Nam, S. K.; Kim, D. H.; Kim, G. N.; Kim, M. S.; Kong, D. J.; Lee, S.; Oh, Y. D.; Sakharov, A.; Son, D. C.; Brochero Cifuentes, J. A.; Kim, H.; Kim, T. J.; Ryu, M. S.; Song, S.; Choi, S.; Go, Y.; Gyun, D.; Hong, B.; Jo, M.; Kim, H.; Kim, Y.; Lee, B.; Lee, K.; Lee, K. S.; Lee, S.; Park, S. K.; Roh, Y.; Yoo, H. D.; Choi, M.; Kim, H.; Kim, J. H.; Lee, J. S. H.; Park, I. C.; Ryu, G.; Choi, Y.; Choi, Y. K.; Goh, J.; Kim, D.; Kwon, E.; Lee, J.; Yu, I.; Juodagalvis, A.; Vaitkus, J.; Ahmed, I.; Ibrahim, Z. A.; Komaragiri, J. R.; Md Ali, M. A. B.; Mohamad Idris, F.; Wan Abdullah, W. A. T.; Yusli, M. N.; Casimiro Linares, E.; Castilla-Valdez, H.; de La Cruz-Burelo, E.; Heredia-de La Cruz, I.; Hernandez-Almada, A.; Lopez-Fernandez, R.; Sanchez-Hernandez, A.; Carrillo Moreno, S.; Vazquez Valencia, F.; Carpinteyro, S.; Pedraza, I.; Salazar Ibarguen, H. A.; Morelos Pineda, A.; Krofcheck, D.; Butler, P. H.; Reucroft, S.; Ahmad, A.; Ahmad, M.; Hassan, Q.; Hoorani, H. R.; Khan, W. A.; Khurshid, T.; Shoaib, M.; Bialkowska, H.; Bluj, M.; Boimska, B.; Frueboes, T.; Górski, M.; Kazana, M.; Nawrocki, K.; Romanowska-Rybinska, K.; Szleper, M.; Zalewski, P.; Brona, G.; Bunkowski, K.; Doroba, K.; Kalinowski, A.; Konecki, M.; Krolikowski, J.; Misiura, M.; Olszewski, M.; Walczak, M.; Bargassa, P.; Beirão da Cruz E Silva, C.; di Francesco, A.; Faccioli, P.; Ferreira Parracho, P. 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V.; Vinogradov, A.; Baskakov, A.; Belyaev, A.; Boos, E.; Bunichev, V.; Dubinin, M.; Dudko, L.; Ershov, A.; Gribushin, A.; Klyukhin, V.; Kodolova, O.; Lokhtin, I.; Myagkov, I.; Obraztsov, S.; Petrushanko, S.; Savrin, V.; Azhgirey, I.; Bayshev, I.; Bitioukov, S.; Kachanov, V.; Kalinin, A.; Konstantinov, D.; Krychkine, V.; Petrov, V.; Ryutin, R.; Sobol, A.; Tourtchanovitch, L.; Troshin, S.; Tyurin, N.; Uzunian, A.; Volkov, A.; Adzic, P.; Ekmedzic, M.; Milosevic, J.; Rekovic, V.; Alcaraz Maestre, J.; Calvo, E.; Cerrada, M.; Chamizo Llatas, M.; Colino, N.; de La Cruz, B.; Delgado Peris, A.; Domínguez Vázquez, D.; Escalante Del Valle, A.; Fernandez Bedoya, C.; Fernández Ramos, J. P.; Flix, J.; Fouz, M. C.; Garcia-Abia, P.; Gonzalez Lopez, O.; Goy Lopez, S.; Hernandez, J. M.; Josa, M. I.; Navarro de Martino, E.; Pérez-Calero Yzquierdo, A.; Puerta Pelayo, J.; Quintario Olmeda, A.; Redondo, I.; Romero, L.; Soares, M. S.; Albajar, C.; de Trocóniz, J. F.; Missiroli, M.; Moran, D.; Brun, H.; Cuevas, J.; Fernandez Menendez, J.; Folgueras, S.; Gonzalez Caballero, I.; Palencia Cortezon, E.; Vizan Garcia, J. M.; Cabrillo, I. J.; Calderon, A.; Castiñeiras de Saa, J. R.; de Castro Manzano, P.; Duarte Campderros, J.; Fernandez, M.; Gomez, G.; Graziano, A.; Lopez Virto, A.; Marco, J.; Marco, R.; Martinez Rivero, C.; Matorras, F.; Munoz Sanchez, F. J.; Piedra Gomez, J.; Rodrigo, T.; Rodríguez-Marrero, A. Y.; Ruiz-Jimeno, A.; Scodellaro, L.; Vila, I.; Vilar Cortabitarte, R.; Abbaneo, D.; Auffray, E.; Auzinger, G.; Bachtis, M.; Baillon, P.; Ball, A. H.; Barney, D.; Benaglia, A.; Bendavid, J.; Benhabib, L.; Benitez, J. F.; Berruti, G. M.; Bloch, P.; Bocci, A.; Bonato, A.; Botta, C.; Breuker, H.; Camporesi, T.; Cerminara, G.; Colafranceschi, S.; D'Alfonso, M.; D'Enterria, D.; Dabrowski, A.; Daponte, V.; David, A.; de Gruttola, M.; de Guio, F.; de Roeck, A.; de Visscher, S.; di Marco, E.; Dobson, M.; Dordevic, M.; Dorney, B.; Du Pree, T.; Dupont, N.; Elliott-Peisert, A.; Franzoni, G.; Funk, W.; Gigi, D.; Gill, K.; Giordano, D.; Girone, M.; Glege, F.; Guida, R.; Gundacker, S.; Guthoff, M.; Hammer, J.; Harris, P.; Hegeman, J.; Innocente, V.; Janot, P.; Kirschenmann, H.; Kortelainen, M. J.; Kousouris, K.; Krajczar, K.; Lecoq, P.; Lourenço, C.; Lucchini, M. T.; Magini, N.; Malgeri, L.; Mannelli, M.; Martelli, A.; Masetti, L.; Meijers, F.; Mersi, S.; Meschi, E.; Moortgat, F.; Morovic, S.; Mulders, M.; Nemallapudi, M. V.; Neugebauer, H.; Orfanelli, S.; Orsini, L.; Pape, L.; Perez, E.; Petrilli, A.; Petrucciani, G.; Pfeiffer, A.; Piparo, D.; Racz, A.; Rolandi, G.; Rovere, M.; Ruan, M.; Sakulin, H.; Schäfer, C.; Schwick, C.; Sharma, A.; Silva, P.; Simon, M.; Sphicas, P.; Spiga, D.; Steggemann, J.; Stieger, B.; Stoye, M.; Takahashi, Y.; Treille, D.; Triossi, A.; Tsirou, A.; Veres, G. I.; Wardle, N.; Wöhri, H. K.; Zagozdzinska, A.; Zeuner, W. D.; Bertl, W.; Deiters, K.; Erdmann, W.; Horisberger, R.; Ingram, Q.; Kaestli, H. C.; Kotlinski, D.; Langenegger, U.; Renker, D.; Rohe, T.; Bachmair, F.; Bäni, L.; Bianchini, L.; Buchmann, M. A.; Casal, B.; Dissertori, G.; Dittmar, M.; Donegà, M.; Dünser, M.; Eller, P.; Grab, C.; Heidegger, C.; Hits, D.; Hoss, J.; Kasieczka, G.; Lustermann, W.; Mangano, B.; Marini, A. 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I.; Henderson, C.; Rumerio, P.; Avetisyan, A.; Bose, T.; Fantasia, C.; Gastler, D.; Lawson, P.; Rankin, D.; Richardson, C.; Rohlf, J.; St. John, J.; Sulak, L.; Zou, D.; Alimena, J.; Berry, E.; Bhattacharya, S.; Cutts, D.; Dhingra, N.; Ferapontov, A.; Garabedian, A.; Heintz, U.; Laird, E.; Landsberg, G.; Mao, Z.; Narain, M.; Sagir, S.; Sinthuprasith, T.; Breedon, R.; Breto, G.; Calderon de La Barca Sanchez, M.; Chauhan, S.; Chertok, M.; Conway, J.; Conway, R.; Cox, P. T.; Erbacher, R.; Gardner, M.; Ko, W.; Lander, R.; Mulhearn, M.; Pellett, D.; Pilot, J.; Ricci-Tam, F.; Shalhout, S.; Smith, J.; Squires, M.; Stolp, D.; Tripathi, M.; Wilbur, S.; Yohay, R.; Cousins, R.; Everaerts, P.; Farrell, C.; Hauser, J.; Ignatenko, M.; Saltzberg, D.; Takasugi, E.; Valuev, V.; Weber, M.; Burt, K.; Clare, R.; Ellison, J.; Gary, J. W.; Hanson, G.; Heilman, J.; Ivova Paneva, M.; Jandir, P.; Kennedy, E.; Lacroix, F.; Long, O. 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T.; Gaz, A.; Jensen, F.; Johnson, A.; Krohn, M.; Mulholland, T.; Nauenberg, U.; Smith, J. G.; Stenson, K.; Wagner, S. R.; Alexander, J.; Chatterjee, A.; Chaves, J.; Chu, J.; Dittmer, S.; Eggert, N.; Mirman, N.; Nicolas Kaufman, G.; Patterson, J. R.; Rinkevicius, A.; Ryd, A.; Skinnari, L.; Soffi, L.; Sun, W.; Tan, S. M.; Teo, W. D.; Thom, J.; Thompson, J.; Tucker, J.; Weng, Y.; Wittich, P.; Abdullin, S.; Albrow, M.; Anderson, J.; Apollinari, G.; Bauerdick, L. A. T.; Beretvas, A.; Berryhill, J.; Bhat, P. C.; Bolla, G.; Burkett, K.; Butler, J. N.; Cheung, H. W. K.; Chlebana, F.; Cihangir, S.; Elvira, V. D.; Fisk, I.; Freeman, J.; Gottschalk, E.; Gray, L.; Green, D.; Grünendahl, S.; Gutsche, O.; Hanlon, J.; Hare, D.; Harris, R. M.; Hirschauer, J.; Hooberman, B.; Hu, Z.; Jindariani, S.; Johnson, M.; Joshi, U.; Jung, A. W.; Klima, B.; Kreis, B.; Kwan, S.; Lammel, S.; Linacre, J.; Lincoln, D.; Lipton, R.; Liu, T.; Lopes de Sá, R.; Lykken, J.; Maeshima, K.; Marraffino, J. M.; Martinez Outschoorn, V. I.; Maruyama, S.; Mason, D.; McBride, P.; Merkel, P.; Mishra, K.; Mrenna, S.; Nahn, S.; Newman-Holmes, C.; O'Dell, V.; Pedro, K.; Prokofyev, O.; Rakness, G.; Sexton-Kennedy, E.; Soha, A.; Spalding, W. J.; Spiegel, L.; Taylor, L.; Tkaczyk, S.; Tran, N. V.; Uplegger, L.; Vaandering, E. W.; Vernieri, C.; Verzocchi, M.; Vidal, R.; Weber, H. A.; Whitbeck, A.; Yang, F.; Yin, H.; Acosta, D.; Avery, P.; Bortignon, P.; Bourilkov, D.; Carnes, A.; Carver, M.; Curry, D.; Das, S.; di Giovanni, G. P.; Field, R. D.; Fisher, M.; Furic, I. K.; Hugon, J.; Konigsberg, J.; Korytov, A.; Low, J. F.; Ma, P.; Matchev, K.; Mei, H.; Milenovic, P.; Mitselmakher, G.; Muniz, L.; Rank, D.; Rossin, R.; Shchutska, L.; Snowball, M.; Sperka, D.; Wang, J.; Wang, S.; Yelton, J.; Hewamanage, S.; Linn, S.; Markowitz, P.; Martinez, G.; Rodriguez, J. L.; Ackert, A.; Adams, J. R.; Adams, T.; Askew, A.; Bochenek, J.; Diamond, B.; Haas, J.; Hagopian, S.; Hagopian, V.; Johnson, K. F.; Khatiwada, A.; Prosper, H.; Veeraraghavan, V.; Weinberg, M.; Bhopatkar, V.; Hohlmann, M.; Kalakhety, H.; Mareskas-Palcek, D.; Roy, T.; Yumiceva, F.; Adams, M. R.; Apanasevich, L.; Berry, D.; Betts, R. R.; Bucinskaite, I.; Cavanaugh, R.; Evdokimov, O.; Gauthier, L.; Gerber, C. E.; Hofman, D. J.; Kurt, P.; O'Brien, C.; Sandoval Gonzalez, I. D.; Silkworth, C.; Turner, P.; Varelas, N.; Wu, Z.; Zakaria, M.; Bilki, B.; Clarida, W.; Dilsiz, K.; Durgut, S.; Gandrajula, R. P.; Haytmyradov, M.; Khristenko, V.; Merlo, J.-P.; Mermerkaya, H.; Mestvirishvili, A.; Moeller, A.; Nachtman, J.; Ogul, H.; Onel, Y.; Ozok, F.; Penzo, A.; Snyder, C.; Tan, P.; Tiras, E.; Wetzel, J.; Yi, K.; Anderson, I.; Barnett, B. A.; Blumenfeld, B.; Fehling, D.; Feng, L.; Gritsan, A. V.; Maksimovic, P.; Martin, C.; Osherson, M.; Roskes, J.; Sarica, U.; Swartz, M.; Xiao, M.; Xin, Y.; You, C.; Baringer, P.; Bean, A.; Benelli, G.; Bruner, C.; Gray, J.; Kenny, R. P.; Majumder, D.; Malek, M.; Murray, M.; Noonan, D.; Sanders, S.; Stringer, R.; Wang, Q.; Wood, J. S.; Chakaberia, I.; Ivanov, A.; Kaadze, K.; Khalil, S.; Makouski, M.; Maravin, Y.; Mohammadi, A.; Saini, L. K.; Skhirtladze, N.; Svintradze, I.; Toda, S.; Lange, D.; Rebassoo, F.; Wright, D.; Anelli, C.; Baden, A.; Baron, O.; Belloni, A.; Calvert, B.; Eno, S. C.; Ferraioli, C.; Gomez, J. A.; Hadley, N. J.; Jabeen, S.; Kellogg, R. G.; Kolberg, T.; Kunkle, J.; Lu, Y.; Mignerey, A. C.; Shin, Y. H.; Skuja, A.; Tonjes, M. B.; Tonwar, S. C.; Apyan, A.; Barbieri, R.; Baty, A.; Bierwagen, K.; Brandt, S.; Busza, W.; Cali, I. A.; Demiragli, Z.; Di Matteo, L.; Gomez Ceballos, G.; Goncharov, M.; Gulhan, D.; Innocenti, G. M.; Klute, M.; Kovalskyi, D.; Lai, Y. S.; Lee, Y.-J.; Levin, A.; Luckey, P. D.; McGinn, C.; Mironov, C.; Niu, X.; Paus, C.; Ralph, D.; Roland, C.; Roland, G.; Salfeld-Nebgen, J.; Stephans, G. S. F.; Sumorok, K.; Varma, M.; Velicanu, D.; Veverka, J.; Wang, J.; Wang, T. W.; Wyslouch, B.; Yang, M.; Zhukova, V.; Dahmes, B.; Finkel, A.; Gude, A.; Hansen, P.; Kalafut, S.; Kao, S. C.; Klapoetke, K.; Kubota, Y.; Lesko, Z.; Mans, J.; Nourbakhsh, S.; Ruckstuhl, N.; Rusack, R.; Tambe, N.; Turkewitz, J.; Acosta, J. G.; Oliveros, S.; Avdeeva, E.; Bloom, K.; Bose, S.; Claes, D. R.; Dominguez, A.; Fangmeier, C.; Gonzalez Suarez, R.; Kamalieddin, R.; Keller, J.; Knowlton, D.; Kravchenko, I.; Lazo-Flores, J.; Meier, F.; Monroy, J.; Ratnikov, F.; Siado, J. E.; Snow, G. R.; Alyari, M.; Dolen, J.; George, J.; Godshalk, A.; Iashvili, I.; Kaisen, J.; Kharchilava, A.; Kumar, A.; Rappoccio, S.; Alverson, G.; Barberis, E.; Baumgartel, D.; Chasco, M.; Hortiangtham, A.; Massironi, A.; Morse, D. M.; Nash, D.; Orimoto, T.; Teixeira de Lima, R.; Trocino, D.; Wang, R.-J.; Wood, D.; Zhang, J.; Hahn, K. A.; Kubik, A.; Mucia, N.; Odell, N.; Pollack, B.; Pozdnyakov, A.; Schmitt, M.; Stoynev, S.; Sung, K.; Trovato, M.; Velasco, M.; Won, S.; Brinkerhoff, A.; Dev, N.; Hildreth, M.; Jessop, C.; Karmgard, D. J.; Kellams, N.; Lannon, K.; Lynch, S.; Marinelli, N.; Meng, F.; Mueller, C.; Musienko, Y.; Pearson, T.; Planer, M.; Reinsvold, A.; Ruchti, R.; Smith, G.; Taroni, S.; Valls, N.; Wayne, M.; Wolf, M.; Woodard, A.; Antonelli, L.; Brinson, J.; Bylsma, B.; Durkin, L. S.; Flowers, S.; Hart, A.; Hill, C.; Hughes, R.; Kotov, K.; Ling, T. Y.; Liu, B.; Luo, W.; Puigh, D.; Rodenburg, M.; Winer, B. L.; Wulsin, H. W.; Driga, O.; Elmer, P.; Hardenbrook, J.; Hebda, P.; Koay, S. A.; Lujan, P.; Marlow, D.; Medvedeva, T.; Mooney, M.; Olsen, J.; Palmer, C.; Piroué, P.; Quan, X.; Saka, H.; Stickland, D.; Tully, C.; Werner, J. S.; Zuranski, A.; Malik, S.; Barnes, V. E.; Benedetti, D.; Bortoletto, D.; Gutay, L.; Jha, M. K.; Jones, M.; Jung, K.; Kress, M.; Miller, D. H.; Neumeister, N.; Primavera, F.; Radburn-Smith, B. C.; Shi, X.; Shipsey, I.; Silvers, D.; Sun, J.; Svyatkovskiy, A.; Wang, F.; Xie, W.; Xu, L.; Zablocki, J.; Parashar, N.; Stupak, J.; Adair, A.; Akgun, B.; Chen, Z.; Ecklund, K. M.; Geurts, F. J. M.; Guilbaud, M.; Li, W.; Michlin, B.; Northup, M.; Padley, B. P.; Redjimi, R.; Roberts, J.; Rorie, J.; Tu, Z.; Zabel, J.; Betchart, B.; Bodek, A.; de Barbaro, P.; Demina, R.; Eshaq, Y.; Ferbel, T.; Galanti, M.; Garcia-Bellido, A.; Goldenzweig, P.; Han, J.; Harel, A.; Hindrichs, O.; Khukhunaishvili, A.; Petrillo, G.; Verzetti, M.; Demortier, L.; Arora, S.; Barker, A.; Chou, J. P.; Contreras-Campana, C.; Contreras-Campana, E.; Duggan, D.; Ferencek, D.; Gershtein, Y.; Gray, R.; Halkiadakis, E.; Hidas, D.; Hughes, E.; Kaplan, S.; Kunnawalkam Elayavalli, R.; Lath, A.; Nash, K.; Panwalkar, S.; Park, M.; Salur, S.; Schnetzer, S.; Sheffield, D.; Somalwar, S.; Stone, R.; Thomas, S.; Thomassen, P.; Walker, M.; Foerster, M.; Riley, G.; Rose, K.; Spanier, S.; York, A.; Bouhali, O.; Castaneda Hernandez, A.; Dalchenko, M.; de Mattia, M.; Delgado, A.; Dildick, S.; Eusebi, R.; Flanagan, W.; Gilmore, J.; Kamon, T.; Krutelyov, V.; Montalvo, R.; Mueller, R.; Osipenkov, I.; Pakhotin, Y.; Patel, R.; Perloff, A.; Roe, J.; Rose, A.; Safonov, A.; Tatarinov, A.; Ulmer, K. A.; Akchurin, N.; Cowden, C.; Damgov, J.; Dragoiu, C.; Dudero, P. R.; Faulkner, J.; Kunori, S.; Lamichhane, K.; Lee, S. W.; Libeiro, T.; Undleeb, S.; Volobouev, I.; Appelt, E.; Delannoy, A. G.; Greene, S.; Gurrola, A.; Janjam, R.; Johns, W.; Maguire, C.; Mao, Y.; Melo, A.; Sheldon, P.; Snook, B.; Tuo, S.; Velkovska, J.; Xu, Q.; Arenton, M. W.; Boutle, S.; Cox, B.; Francis, B.; Goodell, J.; Hirosky, R.; Ledovskoy, A.; Li, H.; Lin, C.; Neu, C.; Wolfe, E.; Wood, J.; Xia, F.; Clarke, C.; Harr, R.; Karchin, P. E.; Kottachchi Kankanamge Don, C.; Lamichhane, P.; Sturdy, J.; Belknap, D. A.; Carlsmith, D.; Cepeda, M.; Christian, A.; Dasu, S.; Dodd, L.; Duric, S.; Friis, E.; Gomber, B.; Hall-Wilton, R.; Herndon, M.; Hervé, A.; Klabbers, P.; Lanaro, A.; Levine, A.; Long, K.; Loveless, R.; Mohapatra, A.; Ojalvo, I.; Perry, T.; Pierro, G. A.; Polese, G.; Ross, I.; Ruggles, T.; Sarangi, T.; Savin, A.; Sharma, A.; Smith, N.; Smith, W. H.; Taylor, D.; Woods, N.; Cms Collaboration

2015-10-01

Constraints on the lifetime and width of the Higgs boson are obtained from H →Z Z →4 ℓ events using data recorded by the CMS experiment during the LHC run 1 with an integrated luminosity of 5.1 and 19.7 fb-1 at a center-of-mass energy of 7 and 8 TeV, respectively. The measurement of the Higgs boson lifetime is derived from its flight distance in the CMS detector with an upper bound of τH<1.9 ×10-13 s at the 95% confidence level (C.L.), corresponding to a lower bound on the width of ΓH>3.5 ×10-9 MeV . The measurement of the width is obtained from an off-shell production technique, generalized to include anomalous couplings of the Higgs boson to two electroweak bosons. From this measurement, a joint constraint is set on the Higgs boson width and a parameter fΛ Q that expresses an anomalous coupling contribution as an on-shell cross-section fraction. The limit on the Higgs boson width is ΓH<46 MeV with fΛ Q unconstrained and ΓH<26 MeV for fΛ Q=0 at the 95% C.L. The constraint fΛ Q<3.8 ×10-3 at the 95% C.L. is obtained for the expected standard model Higgs boson width.

Preparation for a first-in-man lentivirus trial in patients with cystic fibrosis

PubMed Central

Alton, Eric W F W; Beekman, Jeffery M; Boyd, A Christopher; Brand, June; Carlon, Marianne S; Connolly, Mary M; Chan, Mario; Conlon, Sinead; Davidson, Heather E; Davies, Jane C; Davies, Lee A; Dekkers, Johanna F; Doherty, Ann; Gea-Sorli, Sabrina; Gill, Deborah R; Griesenbach, Uta; Hasegawa, Mamoru; Higgins, Tracy E; Hironaka, Takashi; Hyndman, Laura; McLachlan, Gerry; Inoue, Makoto; Hyde, Stephen C; Innes, J Alastair; Maher, Toby M; Moran, Caroline; Meng, Cuixiang; Paul-Smith, Michael C; Pringle, Ian A; Pytel, Kamila M; Rodriguez-Martinez, Andrea; Schmidt, Alexander C; Stevenson, Barbara J; Sumner-Jones, Stephanie G; Toshner, Richard; Tsugumine, Shu; Wasowicz, Marguerite W; Zhu, Jie

2017-01-01

We have recently shown that non-viral gene therapy can stabilise the decline of lung function in patients with cystic fibrosis (CF). However, the effect was modest, and more potent gene transfer agents are still required. Fuson protein (F)/Hemagglutinin/Neuraminidase protein (HN)-pseudotyped lentiviral vectors are more efficient for lung gene transfer than non-viral vectors in preclinical models. In preparation for a first-in-man CF trial using the lentiviral vector, we have undertaken key translational preclinical studies. Regulatory-compliant vectors carrying a range of promoter/enhancer elements were assessed in mice and human air–liquid interface (ALI) cultures to select the lead candidate; cystic fibrosis transmembrane conductance receptor (CFTR) expression and function were assessed in CF models using this lead candidate vector. Toxicity was assessed and ‘benchmarked’ against the leading non-viral formulation recently used in a Phase IIb clinical trial. Integration site profiles were mapped and transduction efficiency determined to inform clinical trial dose-ranging. The impact of pre-existing and acquired immunity against the vector and vector stability in several clinically relevant delivery devices was assessed. A hybrid promoter hybrid cytosine guanine dinucleotide (CpG)- free CMV enhancer/elongation factor 1 alpha promoter (hCEF) consisting of the elongation factor 1α promoter and the cytomegalovirus enhancer was most efficacious in both murine lungs and human ALI cultures (both at least 2-log orders above background). The efficacy (at least 14% of airway cells transduced), toxicity and integration site profile supports further progression towards clinical trial and pre-existing and acquired immune responses do not interfere with vector efficacy. The lead rSIV.F/HN candidate expresses functional CFTR and the vector retains 90–100% transduction efficiency in clinically relevant delivery devices. The data support the progression of the F/HN-pseudotyped lentiviral vector into a first-in-man CF trial in 2017. PMID:27852956

Performance Improvements of the Phoneme Recognition Algorithm.

DTIC Science & Technology

1984-06-01

VECTOR NUNDIRt"tIVECTj Beginning vector ; of speech to be extracted INDEX * MOD(IVECT,4) ICheck for vector being ; last vector in block 63 ILE u ((JUICT...1fIER0) ; Read header block. CALL CHECK(IERO) IHEADER(57) : ICOfP ; Change a of freq. components ICHECK : (IHEADER(56) - ([LENGTH - 1)) * ILENGTH...ICONT .Al. ICHECK ) GO TO 55 ; Check to make sure correct ;amount of vectors have been created# INCR u INCR + 32 ;Jump over last set of components

Modified Newcastle disease virus vectors expressing the H5 hemagglutinin induce enhanced protection against highly pathogenic H5N1 avian influenza virus in chickens

PubMed Central

Kim, Shin-Hee; Paldurai, Anandan; Xiao, Sa; Collins, Peter L.; Samal, Siba K.

2016-01-01

Naturally-occurring attenuated strains of Newcastle disease virus (NDV) are being developed as vaccine vectors for use in poultry and humans. However, some NDV strains, such as Beaudette C (BC), may retain too much virulence in poultry for safe use, and more highly attenuated strains may be suboptimally immunogenic. We therefore modified the BC strain by changing the multibasic cleavage site sequence of the F protein to the dibasic sequence of avirulent strain LaSota. Additionally, the BC, F, and HN proteins were modified in several ways to enhance virus replication. These modified BC-derived vectors and the LaSota strain were engineered to express the hemagglutin (HA) protein of H5N1 highly pathogenic influenza virus (HPAIV). In general, the modified BC-based vectors expressing HA replicated better than LaSota/HA, and expressed higher levels of HA protein. Pathogenicity tests indicated that all the modified viruses were highly attenuated in chickens. Based on in vitro characterization, two of the modified BC vectors were chosen for evaluation in chickens as vaccine vectors against H5N1 HPAIV A/Vietnam/1203/04. Immunization of chickens with rNDV vector vaccines followed by challenge with HPAIV demonstrated high levels of protection against clinical disease and mortality. However, only those chickens immunized with modified BC/HA in which residues 271–330 from the F protein had been replaced with the corresponding sequence from the NDV AKO strain conferred complete protection against challenge virus shedding. Our findings suggest that this modified rNDV can be used safely as a vaccine vector with enhanced replication, expression, and protective efficacy in avian species, and potentially in humans. PMID:24968158

Raman spectroscopy and immunohistochemistry for schwannoma characterization: a case study

NASA Astrophysics Data System (ADS)

Neto, Lazaro P. M.; das Chagas, Maurilio J.; Carvalho, Luis Felipe C. S.; Ferreira, Isabelle; dos Santos, Laurita; Haddad, Marcelo; Loddi, Vinicius; Martin, Airton A.

2016-03-01

The schwannomas is a tumour of the tissue that covers nerves, called the nerve sheath. Schwannomas are often benign tumors of the Schwan cells, which are the principal glia of the peripheral nervous system (PNS). Preoperative diagnosis of this lesion usually is difficult, therefore, new techniques are being studied as pre surgical evaluation. Among these, Raman spectroscopy, that enables the biochemical identification of the tissue analyzed by their optical properties, may be used as a tool for schwannomas diagnosis. The aim of this study was to discriminate between normal nervous tissue and schwannoma through the confocal Raman spectroscopy and Raman optical fiber-based techniques combined with immunohistochemical analysis. Twenty spectra were analyzed from a normal nerve tissue sample (10) and schwannoma (10) by Holospec f / 1.8 (Kayser Optical Systems) coupled to an optical fiber with a 785nm laser line source. The data were pre-processed and vector normalized. The average analysis and standard deviation was performed associated with cluster analysis. AML, 1A4, CD34, Desmin and S-100 protein markers were used for immunohistochemical analysis. Immunohistochemical analysis was positive only for protein S-100 marker which confirmed the neural schwanomma originality. The immunohistochemistry analysis were important to determine the source of the injury, whereas Raman spectroscopy were able to differentiated tissues types indicating important biochemical changes between normal and benign neoplasia.

EC94-42513-3

NASA Image and Video Library

1994-03-15

The three thrust-vectoring aircraft at Edwards, California, each capable of flying at extreme angles of attack, cruise over the California desert in formation during flight in March 1994. They are, from left, NASA's F-18 High Alpha Research Vehicle (HARV), flown by the NASA Dryden Flight Research Center; the X-31, flown by the X-31 International Test Organization (ITO) at Dryden; and the Air Force F-16 Multi-Axis Thrust Vectoring (MATV) aircraft.

Francisella tularensis: an arthropod-borne pathogen

PubMed Central

Petersen, Jeannine M.; Mead, Paul S.; Schriefer, Martin E.

2009-01-01

Arthropod transmission of tularemia occurs throughout the northern hemisphere. Few pathogens show the adaptability of Francisella tularensis to such a wide array of arthropod vectors. Nonetheless, arthropod transmission of F. tularensis was last actively investigated in the first half of the 20th century. This review will focus on arthropod transmission to humans with respect to vector species, modes of transmission, geographic differences and F. tularensis subspecies and clades. PMID:18950590

One-loop renormalization of Lee-Wick gauge theory

DOE Office of Scientific and Technical Information (OSTI.GOV)

Grinstein, Benjamin; O'Connell, Donal

2008-11-15

We examine the renormalization of Lee-Wick gauge theory to one-loop order. We show that only knowledge of the wave function renormalization is necessary to determine the running couplings, anomalous dimensions, and vector boson masses. In particular, the logarithmic running of the Lee-Wick vector boson mass is exactly related to the running of the coupling. In the case of an asymptotically free theory, the vector boson mass runs to infinity in the ultraviolet. Thus, the UV fixed point of the pure gauge theory is an ordinary quantum field theory. We find that the coupling runs more quickly in Lee-Wick gauge theorymore » than in ordinary gauge theory, so the Lee-Wick standard model does not naturally unify at any scale. Finally, we present results on the beta function of more general theories containing dimension six operators which differ from previous results in the literature.« less

Multiprocessing MCNP on an IBM RS/6000 cluster

DOE Office of Scientific and Technical Information (OSTI.GOV)

McKinney, G.W.; West, J.T.

1993-01-01

The advent of high-performance computer systems has brought to maturity programming concepts like vectorization, multiprocessing, and multitasking. While there are many schools of thought as to the most significant factor in obtaining order-of-magnitude increases in performance, such speedup can only be achieved by integrating the computer system and application code. Vectorization leads to faster manipulation of arrays by overlapping instruction CPU cycles. Discrete ordinates codes, which require the solving of large matrices, have proved to be major benefactors of vectorization. Monte Carlo transport, on the other hand, typically contains numerous logic statements and requires extensive redevelopment to benefit from vectorization.more » Multiprocessing and multitasking provide additional CPU cycles via multiple processors. Such systems are generally designed with either common memory access (multitasking) or distributed memory access. In both cases, theoretical speedup, as a function of the number of processors (P) and the fraction of task time that multiprocesses (f), can be formulated using Amdahl's Law S ((f,P) = 1 f + f/P). However, for most applications this theoretical limit cannot be achieved, due to additional terms not included in Amdahl's Law. Monte Carlo transport is a natural candidate for multiprocessing, since the particle tracks are generally independent and the precision of the result increases as the square root of the number of particles tracked.« less

Hyperfine spin interactions between polarons and nuclei in organic light emitting diodes: Magneto-EL measurements

NASA Astrophysics Data System (ADS)

Crooker, S. A.; Kelley, M. R.; Martinez, N.; Nie, W.; Mohite, A. D.; Smith, D. L.; Tretiak, S.; Ruden, P. P.

2014-03-01

Considerable attention in recent years has focused on the effects of applied magnetic fields on the conductance, photocurrent, electroluminescence (EL), and photoluminescence of nominally nonmagnetic organic semiconductor materials and devices. These magnetic field effects have proven useful in revealing the underlying physical mechanisms and relevant spin interactions that influence the electrical and optical properties in these organic systems (e.g., hyperfine coupling, exchange interactions, and spin-orbit coupling). Here we study the field-dependent properties of organic light-emitting diode (OLEDs) based on MTDATA/LiF/Bphen layered structures, in which exciplex recombination at the interface dominates the EL spectra. Small applied magnetic fields (~10 mT) are found to boost the net EL yield by up to 10%, due to a suppression of the mixing between singlet and triplet polaron pairs which, in turn, arises from hyperfine spin coupling of the polarons to the underlying nuclei of the host molecules. We discuss the dependence of these field-induced effects on the LiF barrier thickness, device bias, and on the orientation of the applied magnetic field, as well as the mechanisms responsible.

Measuring the Spin Correlation of Nuclear Muon Capture in HELIUM-3.

NASA Astrophysics Data System (ADS)

McCracken, Dorothy Jill

1996-06-01

We have completed the first measurement of the spin correlation of nuclear muon capture in ^3 He: mu^- + ^3He to nu _{mu} + ^3 H. From this spin correlation, we can extract the induced pseudoscalar form factor, F_{ rm p}, of the weak charged nuclear current. This form factor is not well known experimentally. If nuclear muon capture were a purely leptonic weak interaction, the current would have no pseudoscalar coupling, and therefore F_{rm p} arises from QCD contributions. Since ^3He is a fairly well understood system, a precise measurement of F_{rm p} could provide a direct test of the theories which describe QCD at low energies. This experiment was performed at TRIUMF in Vancouver, BC, using a muon beam. We stopped unpolarized muons in a laser polarized target filled with ^3 He and Rb vapor. The muons were captured into atomic orbitals, forming muonic ^3He which was then polarized via collisions with the optically pumped Rb vapor. When polarized muons undergo nuclear capture in ^3He, the total capture rate is proportional to (1 + {rm A_ {v}P_{v}cos} theta) where theta is the angle between the muon polarization and the triton recoil direction, P_{rm v} is the muon vector polarization and A_ {rm v} is the vector analyzing power. The partially conserved axial current hypothesis (PCAC) predicts that A_{rm v} = 0.524 +/- 0.006 Our measurement of A_{rm v} is in agreement with this prediction: A_{rm v } = 0.604 +/- 0.093 (stat.) _sp{-.142}{+.112}(syst.). This thesis will describe the design, construction, and operation of the device which simultaneously served as a polarized target and a gridded ion chamber. The ion chamber apparatus enabled us to identify recoil tritons as well as determine their direction of motion. The directional information was obtained by fitting the shapes of the pulses generated by the tritons. In addition, this thesis will describe in detail the analysis of these pulses which resulted in a measurement of the raw forward/backward asymmetry of the triton recoil direction. This asymmetry was measured to a precision of 11.5%. With the techniques employed in this experiment, a clear path exists to obtaining a precise measurement of the induced pseudoscalar coupling of the charged weak nuclear current. Plans for a future run, in which we will improve upon these techniques, are underway.

Unification with vector-like fermions and signals at LHC

NASA Astrophysics Data System (ADS)

Bhattacherjee, Biplob; Byakti, Pritibhajan; Kushwaha, Ashwani; Vempati, Sudhir K.

2018-05-01

We look for minimal extensions of Standard Model with vector like fermions leading to precision unification of gauge couplings. Constraints from proton decay, Higgs stability and perturbativity are considered. The simplest models contain several copies of vector fermions in two different (incomplete) representations. Some of these models encompass Type III seesaw mechanism for neutrino masses whereas some others have a dark matter candidate. In all the models, at least one of the candidates has non-trivial representation under SU(3)color. In the limit of vanishing Yukawa couplings, new QCD bound states are formed, which can be probed at LHC. The present limits based on results from 13 TeV already probe these particles for masses around a TeV. Similar models can be constructed with three or four vector representations, examples of which are presented.

F-100 and F-100A on ramp - comparison showing tail modifications that solved control problems during

NASA Technical Reports Server (NTRS)

1955-01-01

On the left is NACA High-Speed Flight Station's North American F-100A (52-5778) Super Sabre with a modified vertical fin. On the right is an Air Force's North American F-100A (52-5773) with the original vertical fin configuration. 1955. NACA added a larger vertical fin to the airplane in December 1954, adding 10 percent more surface area. Later North American installed an even larger fin, having 27 percent greater area, as well as wingtip extensions. The modifications solved the dangerous directional stability and roll coupling problems that the F-100 was experiencing. The F-100 series went on to a long and distinguished service life.

Challenges in inflationary magnetogenesis: Constraints from strong coupling, backreaction, and the Schwinger effect

NASA Astrophysics Data System (ADS)

Sharma, Ramkishor; Jagannathan, Sandhya; Seshadri, T. R.; Subramanian, Kandaswamy

2017-10-01

Models of inflationary magnetogenesis with a coupling to the electromagnetic action of the form f2Fμ νFμ ν , are known to suffer from several problems. These include the strong coupling problem, the backreaction problem and also strong constraints due to the Schwinger effect. We propose a model which resolves all these issues. In our model, the coupling function, f , grows during inflation and transits to a decaying phase post-inflation. This evolutionary behavior is chosen so as to avoid the problem of strong coupling. By assuming a suitable power-law form of the coupling function, we can also neglect backreaction effects during inflation. To avoid backreaction post-inflation, we find that the reheating temperature is restricted to be below ≈1.7 ×104 GeV . The magnetic energy spectrum is predicted to be nonhelical and generically blue. The estimated present day magnetic field strength and the corresponding coherence length taking reheating at the QCD epoch (150 MeV) are 1.4 ×10-12 G and 6.1 ×10-4 Mpc , respectively. This is obtained after taking account of nonlinear processing over and above the flux-freezing evolution after reheating. If we consider also the possibility of a nonhelical inverse transfer, as indicated in direct numerical simulations, the coherence length and the magnetic field strength are even larger. In all cases mentioned above, the magnetic fields generated in our models satisfy the γ -ray bound below a certain reheating temperature.

Vector semirational rogue waves and modulation instability for the coupled higher-order nonlinear Schrödinger equations in the birefringent optical fibers.

PubMed

Sun, Wen-Rong; Liu, De-Yin; Xie, Xi-Yang

2017-04-01

We report the existence and properties of vector breather and semirational rogue-wave solutions for the coupled higher-order nonlinear Schrödinger equations, which describe the propagation of ultrashort optical pulses in birefringent optical fibers. Analytic vector breather and semirational rogue-wave solutions are obtained with Darboux dressing transformation. We observe that the superposition of the dark and bright contributions in each of the two wave components can give rise to complicated breather and semirational rogue-wave dynamics. We show that the bright-dark type vector solitons (or breather-like vector solitons) with nonconstant speed interplay with Akhmediev breathers, Kuznetsov-Ma solitons, and rogue waves. By adjusting parameters, we note that the rogue wave and bright-dark soliton merge, generating the boomeron-type bright-dark solitons. We prove that the rogue wave can be excited in the baseband modulation instability regime. These results may provide evidence of the collision between the mixed ultrashort soliton and rogue wave.

Global constraints on vector-like WIMP effective interactions

DOE PAGES

Blennow, Mattias; Coloma, Pilar; Fernandez-Martinez, Enrique; ...

2016-04-07

In this work we combine information from relic abundance, direct detection, cosmic microwave background, positron fraction, gamma rays, and colliders to explore the existing constraints on couplings between Dark Matter and Standard Model constituents when no underlying model or correlation is assumed. For definiteness, we include independent vector-like effective interactions for each Standard Model fermion. Our results show that low Dark Matter masses below 20 GeV are disfavoured at the 3 σ  level with respect to higher masses, due to the tension between the relic abundance requirement and upper constraints on the Dark Matter couplings. Lastly, large couplings are typically onlymore » allowed in combinations which avoid effective couplings to the nuclei used in direct detection experiments.« less

Isotropy of Angular Frequencies and Weak Chimeras with Broken Symmetry

NASA Astrophysics Data System (ADS)

Bick, Christian

2017-04-01

The notion of a weak chimeras provides a tractable definition for chimera states in networks of finitely many phase oscillators. Here, we generalize the definition of a weak chimera to a more general class of equivariant dynamical systems by characterizing solutions in terms of the isotropy of their angular frequency vector—for coupled phase oscillators the angular frequency vector is given by the average of the vector field along a trajectory. Symmetries of solutions automatically imply angular frequency synchronization. We show that the presence of such symmetries is not necessary by giving a result for the existence of weak chimeras without instantaneous or setwise symmetries for coupled phase oscillators. Moreover, we construct a coupling function that gives rise to chaotic weak chimeras without symmetry in weakly coupled populations of phase oscillators with generalized coupling.

Uncooled Infrared Imaging Face Recognition Using Kernel-Based Feature Vector Selection

DTIC Science & Technology

2006-09-01

j ij i jCI j G G p s t id g id p P t p P P ≥ = = ∀ ∈ (4.10) A visualization of that trade-off relationship is depicted in Figure 4.2...X_train_proj a value a_f a_g end t_hat(:,step)=(pp1(:,1))/sqrt(.2*sum(s2)) end 131 clear A1 A2 Num_replic dim1

DOE Office of Scientific and Technical Information (OSTI.GOV)

Bae, Kyu Jung; Baer, Howard; Serce, Hasan

The supersymmetrized DFSZ axion model is highly motivated not only because it offers solutions to both the gauge hierarchy and strong CP problems, but also because it provides a solution to the SUSY μ-problem which naturally allows for a Little Hierarchy. We compute the expected mixed axion-neutralino dark matter abundance for the SUSY DFSZ axion model in two benchmark cases—a natural SUSY model with a standard neutralino underabundance (SUA) and an mSUGRA/CMSSM model with a standard overabundance (SOA). Our computation implements coupled Boltzmann equations which track the radiation density along with neutralino, axion, axion CO (produced via coherent oscillations), saxion,more » saxion CO, axino and gravitino densities. In the SUSY DFSZ model, axions, axinos and saxions go through the process of freeze-in—in contrast to freeze-out or out-of-equilibrium production as in the SUSY KSVZ model—resulting in thermal yields which are largely independent of the re-heat temperature. We find the SUA case with suppressed saxion-axion couplings (ξ=0) only admits solutions for PQ breaking scale f{sub a}∼< 6× 10{sup 12} GeV where the bulk of parameter space tends to be axion-dominated. For SUA with allowed saxion-axion couplings (ξ =1), then f{sub a} values up to ∼ 10{sup 14} GeV are allowed. For the SOA case, almost all of SUSY DFSZ parameter space is disallowed by a combination of overproduction of dark matter, overproduction of dark radiation or violation of BBN constraints. An exception occurs at very large f{sub a}∼ 10{sup 15}–10{sup 16} GeV where large entropy dilution from CO-produced saxions leads to allowed models.« less

Hydrogenation thermodynamics of melt-spun magnesium rich Mg-Ni nanocrystalline alloys with the addition of multiwalled carbon nanotubes and TiF3

NASA Astrophysics Data System (ADS)

Hou, Xiaojiang; Hu, Rui; Zhang, Tiebang; Kou, Hongchao; Li, Jinshan

2016-02-01

Based on the complexity of hydrogen absorption/desorption process and from the perspective of overall control, the as-cast Mg-10wt%Ni (Mg10Ni) alloy has been successively optimized by melt-spinning and surface catalyzed to realize the internal refinement as well as surface modification. The isothermal hydrogenation behavior of modified Mg-rich alloys has been investigated in this work. The results indicate that melt-spun Mg10Ni catalyzed by multiwalled carbon nanotubes (MWCNTs) coupling with TiF3 possesses superior activation properties and can absorb 6.23 wt% at 250 °C under 2.5 MPa. It is worth mentioning that the hydrogenation capacities of Mg10Ni-MWCNTs-TiF3 are 5.93 wt% and 5.99 wt% within the initial 1 min and 5 min, respectively. Meanwhile, the catalytic effect of MWCNTs and TiF3 has been discussed. The improved activation performance as well as the thermodynamics properties of Mg10Ni catalyzed by MWCNTs and TiF3 is attributed to the synergistic effect on dissociation of H2 molecules, diffusion of H-atoms and heterogeneous nucleation of hydrides.

Higgs constraints from vector boson fusion and scattering

DOE PAGES

Campbell, John M.; Ellis, R. Keith

2015-04-07

We present results on 4-lepton + 2-jet production, the partonic processes most commonly described as vector boson pair production in the Vector Boson Fusion (VBF) mode. That final state contains diagrams that are mediated by Higgs boson exchange. We focus particularly on the high-mass behaviour of the Higgs boson mediated diagrams, which unlike on-shell production, gives information about the Higgs couplings without assumptions on the Higgs boson total width. We assess the sensitivity of the high-mass region to Higgs coupling strengths, considering all vector boson pair channels, W - W +, W ± W ±, W ± Z and ZZ.more » Because of the small background, the most promising mode is W + W + which has sensitivity to Higgs couplings because of Higgs boson exchange in the t-channel. Furthermore, using the Caola-Melnikov (CM) method, the off-shell couplings can be interpreted as bounds on the Higgs boson total width. We estimate the bound that can be obtained with current data, as well as the bounds that could be obtained at √s=13 TeV in the VBF channel for data samples of 100 and 300 fb -1. The CM method has already been successfully applied in the gluon fusion (GGF) production channel. The VBF production channel gives important complementary information, because both production and decay of the Higgs boson occur already at tree graph level.« less

SU-F-J-138: An Extension of PCA-Based Respiratory Deformation Modeling Via Multi-Linear Decomposition

DOE Office of Scientific and Technical Information (OSTI.GOV)

Iliopoulos, AS; Sun, X; Pitsianis, N

Purpose: To address and lift the limited degree of freedom (DoF) of globally bilinear motion components such as those based on principal components analysis (PCA), for encoding and modeling volumetric deformation motion. Methods: We provide a systematic approach to obtaining a multi-linear decomposition (MLD) and associated motion model from deformation vector field (DVF) data. We had previously introduced MLD for capturing multi-way relationships between DVF variables, without being restricted by the bilinear component format of PCA-based models. PCA-based modeling is commonly used for encoding patient-specific deformation as per planning 4D-CT images, and aiding on-board motion estimation during radiotherapy. However, themore » bilinear space-time decomposition inherently limits the DoF of such models by the small number of respiratory phases. While this limit is not reached in model studies using analytical or digital phantoms with low-rank motion, it compromises modeling power in the presence of relative motion, asymmetries and hysteresis, etc, which are often observed in patient data. Specifically, a low-DoF model will spuriously couple incoherent motion components, compromising its adaptability to on-board deformation changes. By the multi-linear format of extracted motion components, MLD-based models can encode higher-DoF deformation structure. Results: We conduct mathematical and experimental comparisons between PCA- and MLD-based models. A set of temporally-sampled analytical trajectories provides a synthetic, high-rank DVF; trajectories correspond to respiratory and cardiac motion factors, including different relative frequencies and spatial variations. Additionally, a digital XCAT phantom is used to simulate a lung lesion deforming incoherently with respect to the body, which adheres to a simple respiratory trend. In both cases, coupling of incoherent motion components due to a low model DoF is clearly demonstrated. Conclusion: Multi-linear decomposition can enable decoupling of distinct motion factors in high-rank DVF measurements. This may improve motion model expressiveness and adaptability to on-board deformation, aiding model-based image reconstruction for target verification. NIH Grant No. R01-184173.« less

Search for a Low-Mass Neutral Higgs Boson with Suppressed Couplings to Fermions Using Events with Multiphoton Final States

DOE Office of Scientific and Technical Information (OSTI.GOV)

Aaltonen, Timo Antero

A search for a Higgs boson with suppressed couplings to fermions,more » $$h_f$$, assumed to be the neutral, lower-mass partner of the Higgs boson discovered at the Large Hadron Collider, is reported. Such a Higgs boson could exist in extensions of the standard model with two Higgs doublets, and could be produced via $$p\\bar{p} \\to H^\\pm h_f \\to W^* h_f h_f \\to 4\\gamma + X$$, where $$H^\\pm$$ is a charged Higgs boson. This analysis uses all events with at least three photons in the final state from proton-antiproton collisions at a center-of-mass energy of 1.96~TeV collected by the Collider Detector at Fermilab, corresponding to an integrated luminosity of 9.2~$${\\rm fb}^{-1}$$. No evidence of a signal is observed in the data. Values of Higgs-boson masses between 10 and 100 GeV/$c^2$ are excluded at 95\\% Bayesian credibility.« less

Search for a Low-Mass Neutral Higgs Boson with Suppressed Couplings to Fermions Using Events with Multiphoton Final States

DOE PAGES

Aaltonen, Timo Antero

2016-06-20

A search for a Higgs boson with suppressed couplings to fermions,more » $$h_f$$, assumed to be the neutral, lower-mass partner of the Higgs boson discovered at the Large Hadron Collider, is reported. Such a Higgs boson could exist in extensions of the standard model with two Higgs doublets, and could be produced via $$p\\bar{p} \\to H^\\pm h_f \\to W^* h_f h_f \\to 4\\gamma + X$$, where $$H^\\pm$$ is a charged Higgs boson. This analysis uses all events with at least three photons in the final state from proton-antiproton collisions at a center-of-mass energy of 1.96~TeV collected by the Collider Detector at Fermilab, corresponding to an integrated luminosity of 9.2~$${\\rm fb}^{-1}$$. No evidence of a signal is observed in the data. Values of Higgs-boson masses between 10 and 100 GeV/$c^2$ are excluded at 95\\% Bayesian credibility.« less

Optical temperature sensing of NaYbF4: Tm3+@SiO2 core-shell micro-particles induced by infrared excitation.

PubMed

Wang, Xiangfu; Zheng, Jin; Xuan, Yan; Yan, Xiaohong

2013-09-09

NaYbF(4):Tm3+@SiO(2) core-shell micro-particles were synthesized by a hydrothermal method and subsequent ultrasonic coating process. Optical temperature sensing has been observed in NaYbF4: Tm(3+)@SiO(2)core-shell micro-particles with a 980 nm infrared laser as excitation source.The fluorescence intensity ratios, optical temperature sensitivity, and temperature dependent population re-distribution ability from the thermally coupled (1)D(2)/(1)G(4) and (3)F(2) /(3)H(4) levels of the Tm(3+) ion have been analyzed as a function of temperature in the range of 100~700 K in order to check its availability as a optical temperature sensor. A better behavior as a lowtemperature sensor has been obtained with a minimum sensitivity of 5.4 × 10(-4) K(-1) at 430 K. It exhibits temperature induced population re-distribution from (1)D(2) /(1)G(4) thermally coupled levels at higher temperature range.

A Fock space coupled cluster study on the electronic structure of the UO(2), UO(2) (+), U(4+), and U(5+) species.

PubMed

Infante, Ivan; Eliav, Ephraim; Vilkas, Marius J; Ishikawa, Yasuyuki; Kaldor, Uzi; Visscher, Lucas

2007-09-28

The ground and excited states of the UO(2) molecule have been studied using a Dirac-Coulomb intermediate Hamiltonian Fock-space coupled cluster approach (DC-IHFSCC). This method is unique in describing dynamic and nondynamic correlation energies at relatively low computational cost. Spin-orbit coupling effects have been fully included by utilizing the four-component Dirac-Coulomb Hamiltonian from the outset. Complementary calculations on the ionized systems UO(2) (+) and UO(2) (2+) as well as on the ions U(4+) and U(5+) were performed to assess the accuracy of this method. The latter calculations improve upon previously published theoretical work. Our calculations confirm the assignment of the ground state of the UO(2) molecule as a (3)Phi(2u) state that arises from the 5f(1)7s(1) configuration. The first state from the 5f(2) configuration is found above 10,000 cm(-1), whereas the first state from the 5f(1)6d(1) configuration is found at 5,047 cm(-1).

Implementation of a transcutaneous charger for fully implantable middle ear hearing device.

PubMed

Lim, H; Yoon, Y; Lee, C; Park, I; Song, B; Cho, J

2005-01-01

A transcutaneous charger for the fully implantable middle ear hearing device (F-IMEHD), which can monitor the charging level of battery, has been designed and implemented. In order to recharge the battery of F-IMEHD, the electromagnetic coupling between primary coil at outer body and secondary coil at inner body has been used. Considering the implant condition of the F-IMEHD, the primary coil and the secondary coil have been designed. Using the resonance of LC tank circuit at each coil, transmission efficiency was increased. Since the primary and the secondary coil are magnetically coupled, the current variation of the primary coil is related with the impedance of internal resonant circuit. Using the principle mentioned above, the implanted module could transmit outward the information about charging state of battery or coupling between two coils by the changing internal impedance. As in the demonstrated results of experiment, the implemented charger has supplied the sufficient operating voltage for the implanted battery within about 10 mm distance. And also, it has been confirmed that the implanted module can transmit information outward by control of internal impedance.

Coherent and conventional gravidynamic quantum 1/f noise

NASA Astrophysics Data System (ADS)

Handel, Peter H.; George, Thomas F.

2008-04-01

Quantum 1/f noise is a fundamental fluctuation of currents, physical cross sections or process rates, caused by infrared coupling of the current carriers to very low frequency (soft) quanta, also known as infraquanta. The latter are soft gravitons in the gravidynamic case with the coupling constant g= pGM2/Nch considered here -- soft photons in the electrodynamic case and soft transversal piezo-phonons in the lattice-dynamical case. Here p=3.14 and F=psi. Quantum 1/f noise is a new aspect of quantum mechanics expressed mainly through the coherent quantum 1/f effect 2g/pf derived here for large systems, and mainly through the conventional quantum 1/f effect for small systems or individual particles. Both effects are present in general, and their effects are superposed in a first approximation with the help of a coherence (weight) parameter s" that will be derived elsewhere for the gravitational case. The spectral density of fractional fluctuations S(dj/j,f) for j=e(hk/2pm)|F|2 is S(F2,f)/<|F|2> = S(j,f)/2 = [4ps"/(1+s")]GM2/pfNch = 4.4 10E9 M2/(pfNgram2). Here s" = 2N'GM/c2=N'rs, where N' is the number of particles of mass M per unit length of the current, rs their Schwarzschild radius, and s" is our coherence (weight) parameter giving the ratio of coherent to conventional quantum 1/f contributions.

On multi-sensitivity with respect to a vector

NASA Astrophysics Data System (ADS)

Jiao, Lixin; Wang, Lidong; Li, Fengquan; Liu, Heng

2018-05-01

Consider the surjective continuous map f: X → X defined on a compact metric space X. Let 𝒦(X) be the space of all non-empty compact subsets of X equipped with the Hausdorff metric and define f¯: 𝒦(X) →𝒦(X) by f¯(A) = {f(a),a ∈ A} for any A ∈𝒦(X). In this paper, we introduce several stronger versions of sensitivities, such as multi-sensitivity with respect to a vector, 𝒩-sensitivity, strong multi-sensitivity. We obtain some basic properties of the concepts of these sensitivities and discuss the relationships with other sensitivities for continuous self-map on [0,1]. Some sufficient conditions for a dynamical system to be 𝒩-sensitive are presented. Also, it is shown that the strong multi-sensitivity of f implies that f¯ is 𝒩-sensitive. In turn, the 𝒩-sensitivity of f¯ implies that f is 𝒩-sensitive. In particular, it is proved that if f is a multi-transitive map with dense periodic sets, then f is 𝒩-sensitive. Finally, we give a multi-sensitive example which is not 𝒩-sensitive.

Cosmic acceleration from matter-curvature coupling

NASA Astrophysics Data System (ADS)

Zaregonbadi, Raziyeh; Farhoudi, Mehrdad

2016-10-01

We consider f( {R,T} ) modified theory of gravity in which, in general, the gravitational Lagrangian is given by an arbitrary function of the Ricci scalar and the trace of the energy-momentum tensor. We indicate that in this type of the theory, the coupling energy-momentum tensor is not conserved. However, we mainly focus on a particular model that matter is minimally coupled to the geometry in the metric formalism and wherein, its coupling energy-momentum tensor is also conserved. We obtain the corresponding Raychaudhuri dynamical equation that presents the evolution of the kinematic quantities. Then for the chosen model, we derive the behavior of the deceleration parameter, and show that the coupling term can lead to an acceleration phase after the matter dominated phase. On the other hand, the curvature of the universe corresponds with the deviation from parallelism in the geodesic motion. Thus, we also scrutinize the motion of the free test particles on their geodesics, and derive the geodesic deviation equation in this modified theory to study the accelerating universe within the spatially flat FLRW background. Actually, this equation gives the relative accelerations of adjacent particles as a measurable physical quantity, and provides an elegant tool to investigate the timelike and the null structures of spacetime geometries. Then, through the null deviation vector, we find the observer area-distance as a function of the redshift for the chosen model, and compare the results with the corresponding results obtained in the literature.

Evaluation of the Friction of Self-Ligating and Conventional Bracket Systems

PubMed Central

Tecco, Simona; Di Iorio, Donato; Nucera, Riccardo; Di Bisceglie, Beatrice; Cordasco, Giancarlo; Festa, Felice

2011-01-01

Objectives: This in vitro study evaluated the friction (F) generated by aligned stainless steel (SS) conventional brackets, self-ligating Damon MX© brackets (SDS Ormco, Glendora, California, USA), Time3© brackets (American Orthodontics, Sheboygan, Wisconsin, USA), Vision LP© brackets (American Orthodontics), and low-friction Slide© ligatures (Leone, Firenze, Italy) coupled with various SS, nickel-titanium (NiTi), and beta-titanium (TMA) archwires. Methods: All brackets had a 0.022-inch slot, and the orthodontic archwires were 0.014-inch, 0.016-inch, 0.014×0.025-inch, 0.018×0.025-inch, and 0.019×0.025-inch NiTi; 0.017×0.025-inch TMA; and 0.019×0.025-inch SS. Each bracket-archwire combination was tested 10 times. In the test, 10 brackets of the same group were mounted in alignment on a metal bar. The archwires moved through all the 10 brackets at a crosshead speed of 0.5 mm/min (each run lasted approximately 5 min). The differences among 5 groups of brackets were analyzed through the Kruskal-Wallis test, and a Mann-Whitney test was calculated as post hoc analysis. The P value was set at 0.05. Results: Coupled with 0.014-inch NiTi and 0.016-inch NiTi, Victory Series© brackets generated the greatest F, while Damon MX© and Vision LP© brackets generated the lowest (P<.05); no significant differences were observed between Time3© brackets and Slide© ligatures. Coupled with all the rectangular archwires, Victory Series© brackets, Slide© ligatures, and Vision LP© self-ligating brackets generated significantly lower F than did Time3© and Damon MX© self-ligating brackets (P<.05). Conclusions: These findings suggest that self-ligating brackets are a family of brackets that, in vitro, can generate different levels of F when coupled with thin or thick, rectangular, or round archwires. Clinical conclusions based on our results are not possible due to the limitations of the experimental conditions. PMID:21769273

The baryon vector current in the combined chiral and 1/Nc expansions

DOE Office of Scientific and Technical Information (OSTI.GOV)

Flores-Mendieta, Ruben; Goity, Jose L

2014-12-01

The baryon vector current is computed at one-loop order in large-Nc baryon chiral perturbation theory, where Nc is the number of colors. Loop graphs with octet and decuplet intermediate states are systematically incorporated into the analysis and the effects of the decuplet-octet mass difference and SU(3) flavor symmetry breaking are accounted for. There are large-Nc cancellations between different one-loop graphs as a consequence of the large-Nc spin-flavor symmetry of QCD baryons. The results are compared against the available experimental data through several fits in order to extract information about the unknown parameters. The large-Nc baryon chiral perturbation theory predictions aremore » in very good agreement both with the expectations from the 1/Nc expansion and with the experimental data. The effect of SU(3) flavor symmetry breaking for the |Delta S|=1 vector current form factors f1(0) results in a reduction by a few percent with respect to the corresponding SU(3) symmetric values.« less

Tests and analysis of a vented D thrust deflecting nozzle on a turbofan engine. [conducted at the outdoor aerodynamic research facility of the Ames Research Center

NASA Technical Reports Server (NTRS)

Roseberg, E. W.

1982-01-01

The objectives were to: obtain nozzle performance characteristics in and out of ground effects; demonstrate the compatibility of the nozzle with a turbofan engine; obtain pressure and temperature distributions on the surface of the D vented nozzle; and establish a correlation of the nozzle performance between small scale and large scale models. The test nozzle was a boilerplate model of the MCAIR D vented nozzle configured for operation with a General Electric YTF-34-F5 turbofan engine. The nozzle was configured to provide: a thrust vectoring range of 0 to 115 deg; a yaw vectoring range of 0 to 10 deg; variable nozzle area control; and variable spacing between the core exit and nozzle entrance station. Compatibility between the YTF-34-T5 turbofan engine and the D vented nozzle was demonstrated. Velocity coefficients of 0.96 and greater were obtained for 90 deg of thrust vectoring. The nozzle walls remained cool during all test conditions.

Enhanced Neutralizing Antibody Response Induced by Respiratory Syncytial Virus Prefusion F Protein Expressed by a Vaccine Candidate

PubMed Central

Liang, Bo; Surman, Sonja; Amaro-Carambot, Emerito; Kabatova, Barbora; Mackow, Natalie; Lingemann, Matthias; Yang, Lijuan; McLellan, Jason S.; Graham, Barney S.; Kwong, Peter D.; Schaap-Nutt, Anne; Collins, Peter L.

2015-01-01

ABSTRACT Respiratory syncytial virus (RSV) and human parainfluenza virus type 3 (HPIV3) are the first and second leading viral agents of severe respiratory tract disease in infants and young children worldwide. Vaccines are not available, and an RSV vaccine is particularly needed. A live attenuated chimeric recombinant bovine/human PIV3 (rB/HPIV3) vector expressing the RSV fusion (F) glycoprotein from an added gene has been under development as a bivalent vaccine against RSV and HPIV3. Previous clinical evaluation of this vaccine candidate suggested that increased genetic stability and immunogenicity of the RSV F insert were needed. This was investigated in the present study. RSV F expression was enhanced 5-fold by codon optimization and by modifying the amino acid sequence to be identical to that of an early passage of the original clinical isolate. This conferred a hypofusogenic phenotype that presumably reflects the original isolate. We then compared vectors expressing stabilized prefusion and postfusion versions of RSV F. In a hamster model, prefusion F induced increased quantity and quality of RSV-neutralizing serum antibodies and increased protection against wild-type (wt) RSV challenge. In contrast, a vector expressing the postfusion F was less immunogenic and protective. The genetic stability of the RSV F insert was high and was not affected by enhanced expression or the prefusion or postfusion conformation of RSV F. These studies provide an improved version of the previously well-tolerated rB/HPIV3-RSV F vaccine candidate that induces a superior RSV-neutralizing serum antibody response. IMPORTANCE Respiratory syncytial virus (RSV) and human parainfluenza virus type 3 (HPIV3) are two major causes of pediatric pneumonia and bronchiolitis. The rB/HPIV3 vector expressing RSV F protein is a candidate bivalent live vaccine against HPIV3 and RSV. Previous clinical evaluation indicated the need to increase the immunogenicity and genetic stability of the RSV F insert. Here, we increased RSV F expression by codon optimization and by modifying the RSV F amino acid sequence to conform to that of an early passage of the original isolate. This resulted in a hypofusogenic phenotype, which likely represents the original phenotype before adaptation to cell culture. We also included stabilized versions of prefusion and postfusion RSV F protein. Prefusion RSV F induced a larger quantity and higher quality of RSV-neutralizing serum antibodies and was highly protective. This provides an improved candidate for further clinical evaluation. PMID:26157122

Enhanced Neutralizing Antibody Response Induced by Respiratory Syncytial Virus Prefusion F Protein Expressed by a Vaccine Candidate.

PubMed

Liang, Bo; Surman, Sonja; Amaro-Carambot, Emerito; Kabatova, Barbora; Mackow, Natalie; Lingemann, Matthias; Yang, Lijuan; McLellan, Jason S; Graham, Barney S; Kwong, Peter D; Schaap-Nutt, Anne; Collins, Peter L; Munir, Shirin

2015-09-01

Respiratory syncytial virus (RSV) and human parainfluenza virus type 3 (HPIV3) are the first and second leading viral agents of severe respiratory tract disease in infants and young children worldwide. Vaccines are not available, and an RSV vaccine is particularly needed. A live attenuated chimeric recombinant bovine/human PIV3 (rB/HPIV3) vector expressing the RSV fusion (F) glycoprotein from an added gene has been under development as a bivalent vaccine against RSV and HPIV3. Previous clinical evaluation of this vaccine candidate suggested that increased genetic stability and immunogenicity of the RSV F insert were needed. This was investigated in the present study. RSV F expression was enhanced 5-fold by codon optimization and by modifying the amino acid sequence to be identical to that of an early passage of the original clinical isolate. This conferred a hypofusogenic phenotype that presumably reflects the original isolate. We then compared vectors expressing stabilized prefusion and postfusion versions of RSV F. In a hamster model, prefusion F induced increased quantity and quality of RSV-neutralizing serum antibodies and increased protection against wild-type (wt) RSV challenge. In contrast, a vector expressing the postfusion F was less immunogenic and protective. The genetic stability of the RSV F insert was high and was not affected by enhanced expression or the prefusion or postfusion conformation of RSV F. These studies provide an improved version of the previously well-tolerated rB/HPIV3-RSV F vaccine candidate that induces a superior RSV-neutralizing serum antibody response. Respiratory syncytial virus (RSV) and human parainfluenza virus type 3 (HPIV3) are two major causes of pediatric pneumonia and bronchiolitis. The rB/HPIV3 vector expressing RSV F protein is a candidate bivalent live vaccine against HPIV3 and RSV. Previous clinical evaluation indicated the need to increase the immunogenicity and genetic stability of the RSV F insert. Here, we increased RSV F expression by codon optimization and by modifying the RSV F amino acid sequence to conform to that of an early passage of the original isolate. This resulted in a hypofusogenic phenotype, which likely represents the original phenotype before adaptation to cell culture. We also included stabilized versions of prefusion and postfusion RSV F protein. Prefusion RSV F induced a larger quantity and higher quality of RSV-neutralizing serum antibodies and was highly protective. This provides an improved candidate for further clinical evaluation. Copyright © 2015, American Society for Microbiology. All Rights Reserved.

Thermalized axion inflation: Natural and monomial inflation with small r

NASA Astrophysics Data System (ADS)

Ferreira, Ricardo Z.; Notari, Alessio

2018-03-01

A safe way to reheat the Universe, in models of natural and quadratic inflation, is through shift symmetric couplings between the inflaton ϕ and the Standard Model (SM), since they do not generate loop corrections to the potential V (ϕ ). We consider such a coupling to SM gauge fields, of the form ϕ F F ˜/f , with sub-Planckian f . In this case, gauge fields can be exponentially produced already during inflation and thermalize via interactions with charged particles, as pointed out in previous work. This can lead to a plasma of temperature T during inflation, and the thermal masses g T of the gauge bosons can equilibrate the system. In addition, inflaton perturbations δ ϕ can also have a thermal spectrum if they have sufficiently large cross sections with the plasma. In this case, inflationary predictions are strongly modified: (1) scalar perturbations are thermal, and so enhanced over the vacuum, leading to a generic way to suppress the tensor-to-scalar ratio r ; (2) the spectral index is ns-1 =η -4 ɛ . After presenting the relevant conditions for thermalization, we show that thermalized natural and monomial models of inflation agree with present observations and have r ≈10-3-10-2, which is within reach of next generation CMB experiments.

Decaying vector dark matter as an explanation for the 3.5 keV line from galaxy clusters

DOE Office of Scientific and Technical Information (OSTI.GOV)

Farzan, Yasaman; Akbarieh, Amin Rezaei, E-mail: yasaman@theory.ipm.ac.ir, E-mail: am_rezaei@physics.sharif.ir

2014-11-01

We present a Vector Dark Matter (VDM) model that explains the 3.5 keV line recently observed in the XMM-Newton observatory data from galaxy clusters. In this model, dark matter is composed of two vector bosons, V and V', which couple to the photon through an effective generalized Chern-Simons coupling, g{sub V}. V' is slightly heavier than V with a mass splitting m{sub V'} – m{sub V} ≅ 3.5 keV. The decay of V' to V and a photon gives rise to the 3.5 keV line. The production of V and V' takes place in the early universe within the freeze-in framework through the effectivemore » g{sub V} coupling when m{sub V'} < T < Λ, Λ being the cut-off above which the effective g{sub V} coupling is not valid. We introduce a high energy model that gives rise to the g{sub V} coupling at low energies. To do this, V and V' are promoted to gauge bosons of spontaneously broken new U(1){sub V} and U(1){sub V'} gauge symmetries, respectively. The high energy sector includes milli-charged chiral fermions that lead to the g{sub V} coupling at low energy via triangle diagrams.« less

A flippon related singlet at the LHC II

DOE Office of Scientific and Technical Information (OSTI.GOV)

Li, Tianjun; Maxin, James A.; Mayes, Van E.

2016-06-28

Here, we consider the 750 GeV diphoton resonance at the 13 TeV LHC in the ℱ-SU(5) model with a Standard Model (SM) singlet field which couples to TeV-scale vector-like particles, dubbed flippons. This singlet field assumes the role of the 750 GeV resonance, with production via gluon fusion and subsequent decay to a diphoton via the vector-like particle loops. We present a numerical analysis showing that the observed 8 TeV and 13 TeV diphoton production cross-sections can be generated in the model space with realistic electric charges and Yukawa couplings for light vector-like masses. We further discuss the experimental viabilitymore » of light vector-like masses in a General No-Scale ℱ-SU(5) model, offering a few benchmark scenarios in this consistent GUT that can satisfy all experimental constraints imposed by the LHC and other essential experiments.« less

Functional characterization of adenoviral/retroviral chimeric vectors and their use for efficient screening of retroviral producer cell lines.

PubMed

Duisit, G; Salvetti, A; Moullier, P; Cosset, F L

1999-01-20

We have generated three different E1-deleted replication-defective adenoviral vectors expressing either Moloney murine leukemia virus (Mo-MuLV) Gag-Pol core particle proteins, gibbon ape leukemia virus (GALV) envelope glycoproteins, or an MuLV-derived retroviral vector genome encoding mCD2 antigen, a murine cell surface marker easily detectable by flow cytometry. Each of the three vectors was first characterized individually by infection of cells providing the complementary retroviral function(s) and able to induce the production of retroviral vectors with an efficiency similar to or higher than that of FLY stable retroviral packaging cells [Cosset, F.-L., Takeuchi, Y., Battini, J.-L., Weiss, R.A., and Collins, M.K.L., (1995). J. Virol. 69, 7430-7436]. In small-scale pilot experiments, TE671 cells simultaneously coinfected with the three adenoviral vectors efficiently released helper-free retroviral vectors in their supernatant, with titers greater than 10(6) infectious particles per milliliter by end-point titrations. Our results also indicated that in contrast to retroviral vector-packageable RNAs, the adenovirus-mediated overexpression of both Gag-Pol and Env packaging functions had limited impact on retroviral titers. The primary mechanism suspected is the premature intracellular cleavage of the Pr65gag precursor that we found in gag-pol-expressing cells, which in turn may impair the normal incorporation of high loads of functional Env. Last, the characterization of the adenoviral/retroviral chimeric vectors allowed the screening of various primate cells for retroviral production and we found that three hepatocyte-derived cell lines were highly efficient in the assembly and release of infectious retroviral particles.

Genetic transformation of Fusarium avenaceum by Agrobacterium tumefaciens mediated transformation and the development of a USER-Brick vector construction system

PubMed Central

2014-01-01

Background The plant pathogenic and saprophytic fungus Fusarium avenaceum causes considerable in-field and post-field losses worldwide due to its infections of a wide range of different crops. Despite its significant impact on the profitability of agriculture production and a desire to characterize the infection process at the molecular biological level, no genetic transformation protocol has yet been established for F. avenaceum. In the current study, it is shown that F. avenaceum can be efficiently transformed by Agrobacterium tumefaciens mediated transformation. In addition, an efficient and versatile single step vector construction strategy relying on Uracil Specific Excision Reagent (USER) Fusion cloning, is developed. Results The new vector construction system, termed USER-Brick, is based on a limited number of PCR amplified vector fragments (core USER-Bricks) which are combined with PCR generated fragments from the gene of interest. The system was found to have an assembly efficiency of 97% with up to six DNA fragments, based on the construction of 55 vectors targeting different polyketide synthase (PKS) and PKS associated transcription factor encoding genes in F. avenaceum. Subsequently, the ΔFaPKS3 vector was used for optimizing A. tumefaciens mediated transformation (ATMT) of F. avenaceum with respect to six variables. Acetosyringone concentration, co-culturing time, co-culturing temperature and fungal inoculum were found to significantly impact the transformation frequency. Following optimization, an average of 140 transformants per 106 macroconidia was obtained in experiments aimed at introducing targeted genome modifications. Targeted deletion of FaPKS6 (FA08709.2) in F. avenaceum showed that this gene is essential for biosynthesis of the polyketide/nonribosomal compound fusaristatin A. Conclusion The new USER-Brick system is highly versatile by allowing for the reuse of a common set of building blocks to accommodate seven different types of genome modifications. New USER-Bricks with additional functionality can easily be added to the system by future users. The optimized protocol for ATMT of F. avenaceum represents the first reported targeted genome modification by double homologous recombination of this plant pathogen and will allow for future characterization of this fungus. Functional linkage of FaPKS6 to the production of the mycotoxin fusaristatin A serves as a first testimony to this. PMID:25048842

DOE Office of Scientific and Technical Information (OSTI.GOV)

Aharony, Ofer; Benini, Francesco; Hsin, Po -Shen

In the last few years several dualities were found between the low-energy behaviors of Chern-Simons-matter theories with unitary gauge groups coupled to scalars, and similar theories coupled to fermions. In this paper we generalize those dualities to orthogonal and symplectic gauge groups. In particular, we conjecture dualities between SO(N) k Chern-Simons theories coupled to N f real scalars in the fundamental representation, and SO(k)- N+N f /2 coupled to N f real (Majorana) fermions in the fundamental. For N f = 0 these are just level-rank dualities of pure Chern-Simons theories, whose precise form we clarify. They lead us tomore » propose new gapped boundary states of topological insulators and superconductors. As a result, for k = 1 we get an interesting low-energy duality between N f free Majorana fermions and an SO( N) 1 Chern-Simons theory coupled to N f scalar fields (with N f ≤ N-2).« less

Flux-gate magnetic field sensor based on yttrium iron garnet films for magnetocardiography investigations

NASA Astrophysics Data System (ADS)

Vetoshko, P. M.; Gusev, N. A.; Chepurnova, D. A.; Samoilova, E. V.; Syvorotka, I. I.; Syvorotka, I. M.; Zvezdin, A. K.; Korotaeva, A. A.; Belotelov, V. I.

2016-08-01

A new type of f lux-gate vector magnetometer based on epitaxial yttrium iron garnet films has been developed and constructed for magnetocardiography (MCG) investigations. The magnetic field sensor can operate at room temperature and measure MCG signals at a distance of about 1 mm from the thoracic cage. The high sensitivity of the sensor, better than 100 fT/Hz1/2, is demonstrated by the results of MCG measurements on rats. The main MCG pattern details and R-peak on a level of 10 pT are observed without temporal averaging, which allows heart rate anomalies to be studied. The proposed magnetic sensors can be effectively used in MCG investigations.

Vector magnetometer based on synchronous manipulation of nitrogen-vacancy centers in all crystal directions

NASA Astrophysics Data System (ADS)

Zhang, Chen; Yuan, Heng; Zhang, Ning; Xu, Lixia; Zhang, Jixing; Li, Bo; Fang, Jiancheng

2018-04-01

Negatively charged nitrogen vacancy (NV‑) centers in diamond have been extensively studied as high-sensitivity magnetometers, showcasing a wide range of applications. This study experimentally demonstrates a vector magnetometry scheme based on synchronous manipulation of NV‑ center ensembles in all crystal directions using double frequency microwaves (MWs) and multi-coupled-strip-lines (mCSL) waveguide. The application of the mCSL waveguide ensures a high degree of synchrony (99%) for manipulating NV‑ centers in multiple orientations in a large volume. Manipulation with double frequency MWs makes NV‑ centers of all four crystal directions involved, and additionally leads to an enhancement of the manipulation field. In this work, by monitoring the changes in the slope of the resonance line consisting of multi-axes NV‑ centers, measurement of the direction of the external field vector was demonstrated with a sensitivity of {{10}\\prime}/\\sqrt{Hz} . Based on the scheme, the fluorescence signal contrast was improved by four times higher and the sensitivity to the magnetic field strength was improved by two times. The method provides a more practical way of achieving vector sensors based on NV‑ center ensembles in diamond.

Generation of Kerr combs centered at 4.5 μm in crystalline microresonators pumped with quantum-cascade lasers.

PubMed

Savchenkov, Anatoliy A; Ilchenko, Vladimir S; Di Teodoro, Fabio; Belden, Paul M; Lotshaw, William T; Matsko, Andrey B; Maleki, Lute

2015-08-01

We report on the generation of mid-infrared Kerr frequency combs in high-finesse CaF2 and MgF2 whispering-gallery-mode resonators pumped with continuous-wave room-temperature quantum cascade lasers. The combs were centered at 4.5 μm, the longest wavelength to date. A frequency comb wider than one half of an octave was demonstrated when approximately 20 mW of pump power was coupled to an MgF2 resonator characterized with quality factor exceeding 10(8).

Ghost instabilities of cosmological models with vector fields nonminimally coupled to the curvature

DOE Office of Scientific and Technical Information (OSTI.GOV)

Himmetoglu, Burak; Peloso, Marco; Contaldi, Carlo R.

2009-12-15

We prove that many cosmological models characterized by vectors nonminimally coupled to the curvature (such as the Turner-Widrow mechanism for the production of magnetic fields during inflation, and models of vector inflation or vector curvaton) contain ghosts. The ghosts are associated with the longitudinal vector polarization present in these models and are found from studying the sign of the eigenvalues of the kinetic matrix for the physical perturbations. Ghosts introduce two main problems: (1) they make the theories ill defined at the quantum level in the high energy/subhorizon regime (and create serious problems for finding a well-behaved UV completion), andmore » (2) they create an instability already at the linearized level. This happens because the eigenvalue corresponding to the ghost crosses zero during the cosmological evolution. At this point the linearized equations for the perturbations become singular (we show that this happens for all the models mentioned above). We explicitly solve the equations in the simplest cases of a vector without a vacuum expectation value in a Friedmann-Robertson-Walker geometry, and of a vector with a vacuum expectation value plus a cosmological constant, and we show that indeed the solutions of the linearized equations diverge when these equations become singular.« less

Algebraic and radical potential fields. Stability domains in coordinate and parametric space

NASA Astrophysics Data System (ADS)

Uteshev, Alexei Yu.

2018-05-01

A dynamical system d X/d t = F(X; A) is treated where F(X; A) is a polynomial (or some general type of radical contained) function in the vectors of state variables X ∈ ℝn and parameters A ∈ ℝm. We are looking for stability domains in both spaces, i.e. (a) domain ℙ ⊂ ℝm such that for any parameter vector specialization A ∈ ℙ, there exists a stable equilibrium for the dynamical system, and (b) domain 𝕊 ⊂ ℝn such that any point X* ∈ 𝕊 could be made a stable equilibrium by a suitable specialization of the parameter vector A.

A high-sensitivity tunable two-beam fiber-coupled high-density magnetometer with laser heating

DOE PAGES

Savukov, Igor Mykhaylovich; Boshier, Malcolm Geoffrey

2016-10-13

Atomic magnetometers (AM) are finding many applications in biomagnetism, national security, industry, and science. Fiber-coupled (FC) designs promise to make them compact and flexible for operation. Most FC designs are based on a single-beam configuration or electrical heating. Here, we demonstrate a two-beam FC AM with laser heating that has 5 fT/Hz 1/2 sensitivity at low frequency (50 Hz), which is higher than that of other fiber-coupled magnetometers and can be improved to the sub-femtotesla level. Here, this magnetometer is widely tunable from DC to very high frequencies (as high as 100 MHz; the only issue might be the applicationmore » of a suitable uniform and stable bias field) with a sensitivity under 10 fT/Hz 1/2 and can be used for magneto-encephalography (MEG), magneto-cardiography (MCG), underground communication, ultra-low MRI/NMR, NQR detection, and other applications.« less

A High-Sensitivity Tunable Two-Beam Fiber-Coupled High-Density Magnetometer with Laser Heating

PubMed Central

Savukov, Igor; Boshier, Malcolm G.

2016-01-01

Atomic magnetometers (AM) are finding many applications in biomagnetism, national security, industry, and science. Fiber-coupled (FC) designs promise to make them compact and flexible for operation. Most FC designs are based on a single-beam configuration or electrical heating. Here, we demonstrate a two-beam FC AM with laser heating that has 5 fT/Hz1/2 sensitivity at low frequency (50 Hz), which is higher than that of other fiber-coupled magnetometers and can be improved to the sub-femtotesla level. This magnetometer is widely tunable from DC to very high frequencies (as high as 100 MHz; the only issue might be the application of a suitable uniform and stable bias field) with a sensitivity under 10 fT/Hz1/2 and can be used for magneto-encephalography (MEG), magneto-cardiography (MCG), underground communication, ultra-low MRI/NMR, NQR detection, and other applications. PMID:27754358

Soliton trapping in fiber lasers.

PubMed

Zhao, L M; Tang, D Y; Zhang, H; Wu, X; Xiang, N

2008-06-23

We report on the soliton trapping in a fiber ring laser modelocked with a SESAM. It was observed that solitons along the two orthogonal polarization directions of the cavity with fairly large difference in central frequency and energy could be coupled together to form a group velocity locked vector soliton. In particular, due to that each of the coupled solitons forms its own soliton sidebands, two sets of soliton sidebands could be observed on the vector soliton spectrum. Numerical simulations have well confirmed the experimental observations.

Compositional and phase relations among rare earth element minerals

NASA Technical Reports Server (NTRS)

Burt, D. M.

1990-01-01

This paper discusses the compositional and phase relationships among minerals in which rare earth elements (REE) occur as essential constituents (e.g., bastnaesite, monazite, xenotime, aeschynite, allanite). Particular consideration is given to the vector representation of complex coupled substitutions in selected REE-bearing minerals and to the REE partitioning between minerals as related to the acid-base tendencies and mineral stabilities. It is shown that the treatment of coupled substitutions as vector quantities facilitates graphical representation of mineral composition spaces.

Novel, Post-Stall, Thrust-Vectored F-15 RPVs: Laboratory and Flight Tests

DTIC Science & Technology

1990-04-24

Flight Tests Program Manager : Douglas Bowers 1ST-Year Report Principal Investigator: Benjamin 6al-Or April 24, 1990 DTIC.LECTE AUG201990 i/ E...constructed. The geometry, dimensions and preliminary wind-tunnel test data for such a design are provided In Appendix A. If funded, such a 3rd...Preliminary Calibration Flight Test Data Obtained from the Onboard Computer ........ 33 Talless, PST-RaNPAS, Roll-Yaw-Pitch, Thrust-Vectored, PST F-15 (Cf. ADp

Modeling of Interactions of Ablated Plumes

DTIC Science & Technology

2008-02-01

code was tested and verified using the Sedov-Taylor explosion problem 24. The grid 300 x 300 is used so as the single code run takes 30 minutes in a...still air and b) temperature contours along with the vector field for 20 km at t-10ps. 9 Final report AFOSR FA9550-07-1-0457 February 2008 0960014 09 C ow...ia Figue9FrainoIeodr shok wves a-)pesr otus0 )~22,bt4F,adetJ n d) het trnsferat te TPSw9PS 00 As 10 04 J. ’ Figure 9:Formation of secondary shock

Multiprocessing MCNP on an IBN RS/6000 cluster

DOE Office of Scientific and Technical Information (OSTI.GOV)

McKinney, G.W.; West, J.T.

1993-01-01

The advent of high-performance computer systems has brought to maturity programming concepts like vectorization, multiprocessing, and multitasking. While there are many schools of thought as to the most significant factor in obtaining order-of-magnitude increases in performance, such speedup can only be achieved by integrating the computer system and application code. Vectorization leads to faster manipulation of arrays by overlapping instruction CPU cycles. Discrete ordinates codes, which require the solving of large matrices, have proved to be major benefactors of vectorization. Monte Carlo transport, on the other hand, typically contains numerous logic statements and requires extensive redevelopment to benefit from vectorization.more » Multiprocessing and multitasking provide additional CPU cycles via multiple processors. Such systems are generally designed with either common memory access (multitasking) or distributed memory access. In both cases, theoretical speedup, as a function of the number of processors P and the fraction f of task time that multiprocesses, can be formulated using Amdahl's law: S(f, P) =1/(1-f+f/P). However, for most applications, this theoretical limit cannot be achieved because of additional terms (e.g., multitasking overhead, memory overlap, etc.) that are not included in Amdahl's law. Monte Carlo transport is a natural candidate for multiprocessing because the particle tracks are generally independent, and the precision of the result increases as the square Foot of the number of particles tracked.« less

Multiprocessing MCNP on an IBM RS/6000 cluster

DOE Office of Scientific and Technical Information (OSTI.GOV)

McKinney, G.W.; West, J.T.

1993-03-01

The advent of high-performance computer systems has brought to maturity programming concepts like vectorization, multiprocessing, and multitasking. While there are many schools of thought as to the most significant factor in obtaining order-of-magnitude increases in performance, such speedup can only be achieved by integrating the computer system and application code. Vectorization leads to faster manipulation of arrays by overlapping instruction CPU cycles. Discrete ordinates codes, which require the solving of large matrices, have proved to be major benefactors of vectorization. Monte Carlo transport, on the other hand, typically contains numerous logic statements and requires extensive redevelopment to benefit from vectorization.more » Multiprocessing and multitasking provide additional CPU cycles via multiple processors. Such systems are generally designed with either common memory access (multitasking) or distributed memory access. In both cases, theoretical speedup, as a function of the number of processors (P) and the fraction of task time that multiprocesses (f), can be formulated using Amdahl`s Law S ((f,P) = 1 f + f/P). However, for most applications this theoretical limit cannot be achieved, due to additional terms not included in Amdahl`s Law. Monte Carlo transport is a natural candidate for multiprocessing, since the particle tracks are generally independent and the precision of the result increases as the square root of the number of particles tracked.« less

Limits on the Higgs boson lifetime and width from its decay to four charged leptons

DOE PAGES

Khachatryan, Vardan

2015-10-22

Constraints on the lifetime and width of the Higgs boson are obtained from H → ZZ → 4ℓ events using data recorded by the CMS experiment during the LHC run 1 with an integrated luminosity of 5.1 and 19.7 fb -1 at a center-of-mass energy of 7 and 8 TeV, respectively. The measurement of the Higgs boson lifetime is derived from its flight distance in the CMS detector with an upper bound of τ H < 1.9 × 10 -13 s at the 95% confidence level (C.L.), corresponding to a lower bound on the width of Γ H > 3.5more » × 10 -9 MeV. The measurement of the width is obtained from an off-shell production technique, generalized to include anomalous couplings of the Higgs boson to two electroweak bosons. From our measurement, a joint constraint is set on the Higgs boson width and a parameter f ΛQ that expresses an anomalous coupling contribution as an on-shell cross-section fraction. Additionally, the limit on the Higgs boson width is Γ H<46 MeV with f ΛQ unconstrained and Γ H < 26 MeV for f ΛQ = 0 at the 95% C.L. The constraint f ΛQ < 3.8 × 10 -3 at the 95% C.L. is obtained for the expected standard model Higgs boson width.« less

Einstein-aether theory: dynamics of relativistic particles with spin or polarization in a Gödel-type universe

DOE Office of Scientific and Technical Information (OSTI.GOV)

Balakin, Alexander B.; Popov, Vladimir A., E-mail: alexander.balakin@kpfu.ru, E-mail: vladipopov@mail.ru

In the framework of the Einstein-aether theory we consider a cosmological model, which describes the evolution of the unit dynamic vector field with activated rotational degree of freedom. We discuss exact solutions of the Einstein-aether theory, for which the space-time is of the Gödel-type, the velocity four-vector of the aether motion is characterized by a non-vanishing vorticity, thus the rotational vectorial modes can be associated with the source of the universe rotation. The main goal of our paper is to study the motion of test relativistic particles with a vectorial internal degree of freedom (spin or polarization), which is coupledmore » to the unit dynamic vector field. The particles are considered as the test ones in the given space-time background of the Gödel-type; the spin (polarization) coupling to the unit dynamic vector field is modeled using exact solutions of three types. The first exact solution describes the aether with arbitrary Jacobson's coupling constants; the second one relates to the case, when the Jacobson's constant responsible for the vorticity is vanishing; the third exact solution is obtained using three constraints for the coupling constants. The analysis of the exact expressions, which are obtained for the particle momentum and for the spin (polarization) four-vector components, shows that the interaction of the spin (polarization) with the unit vector field induces a rotation, which is additional to the geodesic precession of the spin (polarization) associated with the universe rotation as a whole.« less

Characterization of the temperature-sensitive reaction of F1-ATPase by using single-molecule manipulation

PubMed Central

Watanabe, Rikiya; Noji, Hiroyuki

2014-01-01

F1-ATPase (F1) is a rotary motor protein that couples ATP hydrolysis to mechanical rotation with high efficiency. In our recent study, we observed a highly temperature-sensitive (TS) step in the reaction catalyzed by a thermophilic F1 that was characterized by a rate constant remarkably sensitive to temperature and had a Q10 factor of 6–19. Since reactions with high Q10 values are considered to involve large conformational changes, we speculated that the TS reaction plays a key role in the rotation of F1. To clarify the role of the TS reaction, in this study, we conducted a stall and release experiment using magnetic tweezers, and assessed the torque generated during the TS reaction. The results indicate that the TS reaction generates the same amount of rotational torque as does ATP binding, but more than that generated during ATP hydrolysis. Thus, we confirmed that the TS reaction contributes significantly to the rotation of F1. PMID:24825532

Variability of segment coordination using a vector coding technique: Reliability analysis for treadmill walking and running.

PubMed

Hafer, Jocelyn F; Boyer, Katherine A

2017-01-01

Coordination variability (CV) quantifies the variety of movement patterns an individual uses during a task and may provide a measure of the flexibility of that individual's motor system. While there is growing popularity of segment CV as a marker of motor system health or adaptability, it is not known how many strides of data are needed to reliably calculate CV. This study aimed to determine the number of strides needed to reliably calculate CV in treadmill walking and running, and to compare CV between walking and running in a healthy population. Ten healthy young adults walked and ran at preferred speeds on a treadmill and a modified vector coding technique was used to calculate CV for the following segment couples: pelvis frontal plane vs. thigh frontal plane, thigh sagittal plane vs. shank sagittal plane, thigh sagittal plane vs. shank transverse plane, and shank transverse plane vs. rearfoot frontal plane. CV for each coupling of interest was calculated for 2-15 strides for each participant and gait type. Mean CV was calculated across the entire gait cycle and, separately, for 4 phases of the gait cycle. For running and walking 8 and 10 strides, respectively, were sufficient to obtain a reliable CV estimate. CV was significantly different between walking and running for the thigh vs. shank couple comparisons. These results suggest that 10 strides of treadmill data are needed to reliably calculate CV for walking and running. Additionally, the differences in CV between walking and running suggest that the role of knee (i.e., inter-thigh- shank) control may differ between these forms of locomotion. Copyright © 2016 Elsevier B.V. All rights reserved.

Low-cost and eco-friendly green synthesis of silver nanoparticles using Feronia elephantum (Rutaceae) against Culex quinquefasciatus, Anopheles stephensi, and Aedes aegypti (Diptera: Culicidae).

PubMed

Veerakumar, Kaliyan; Govindarajan, Marimuthu; Rajeswary, Mohan; Muthukumaran, Udaiyan

2014-05-01

Mosquitoes transmit serious human diseases, causing millions of deaths every year. The use of synthetic insecticides to control vector mosquitoes has caused physiological resistance and adverse environmental effects in addition to high operational cost. Insecticides of synthesized natural products for vector control have been a priority in this area. In the present study, the larvicidal activity of silver nanoparticles (AgNPs) synthesized using Feronia elephantum plant leaf extract against late third-instar larvae of Anopheles stephensi, Aedes aegypti, and Culex quinquefasciatus was determined. The range of concentrations of synthesized AgNPs (5, 10, 15, 20, and 25 μg mL(-1)) and aqueous leaf extract (25, 50, 75, 100, and 125 μg mL(-1)) were tested against the larvae of A. stephensi, A. aegypti, and C. quinquefasciatus. Larvae were exposed to varying concentrations of aqueous crude extract and synthesized AgNPs for 24 h. Considerable mortality was evident after the treatment of F. elephantum for all three important vector mosquitoes. The synthesized AgNPs from F. elephantum were highly toxic than crude leaf aqueous extract to three important vector mosquito species. The results were recorded from UV-visible spectroscopy, Fourier transform infrared spectroscopy (FTIR), scanning electron microscopy (SEM), and energy-dispersive X-ray spectroscopy analysis (EDX). Synthesized AgNPs against the vector mosquitoes A. stephensi, A. aegypti, and C. quinquefasciatus had the following LC50 and LC90 values: A. stephensi had LC50 and LC90 values of 11.56 and 20.56 μg mL(-1); A. aegypti had LC50 and LC90 values of 13.13 and 23.12 μg mL(-1); and C. quinquefasciatus had LC50 and LC90 values of 14.19 and 24.30 μg mL(-1). No mortality was observed in the control. These results suggest that the green synthesis of silver nanoparticles using F. elephantum has the potential to be used as an ideal eco-friendly approach for the control of A. stephensi, A. aegypti, and C. quinquefasciatus. This is the first report on the mosquito larvicidal activity of the plant extracts and synthesized nanoparticles.

Research flight-control system development for the F-18 high alpha research vehicle

NASA Technical Reports Server (NTRS)

Pahle, Joseph W.; Powers, Bruce; Regenie, Victoria; Chacon, Vince; Degroote, Steve; Murnyak, Steven

1991-01-01

The F-18 high alpha research vehicle was recently modified by adding a thrust vectoring control system. A key element in the modification was the development of a research flight control system integrated with the basic F-18 flight control system. Discussed here are design requirements, system development, and research utility of the resulting configuration as an embedded system for flight research in the high angle of attack regime. Particular emphasis is given to control system modifications and control law features required for high angle of attack flight. Simulation results are used to illustrate some of the thrust vectoring control system capabilities and predicted maneuvering improvements.

Non-transmissible Sendai virus vector encoding c-myc suppressor FBP-interacting repressor for cancer therapy

PubMed Central

Matsushita, Kazuyuki; Shimada, Hideaki; Ueda, Yasuji; Inoue, Makoto; Hasegawa, Mamoru; Tomonaga, Takeshi; Matsubara, Hisahiro; Nomura, Fumio

2014-01-01

AIM: To investigate a novel therapeutic strategy to target and suppress c-myc in human cancers using far up stream element (FUSE)-binding protein-interacting repressor (FIR). METHODS: Endogenous c-Myc suppression and apoptosis induction by a transient FIR-expressing vector was examined in vivo via a HA-tagged FIR (HA-FIR) expression vector. A fusion gene-deficient, non-transmissible, Sendai virus (SeV) vector encoding FIR cDNA, SeV/dF/FIR, was prepared. SeV/dF/FIR was examined for its gene transduction efficiency, viral dose dependency of antitumor effect and apoptosis induction in HeLa (cervical squamous cell carcinoma) cells and SW480 (colon adenocarcinoma) cells. Antitumor efficacy in a mouse xenograft model was also examined. The molecular mechanism of the anti-tumor effect and c-Myc suppression by SeV/dF/FIR was examined using Spliceostatin A (SSA), a SAP155 inhibitor, or SAP155 siRNA which induce c-Myc by increasing FIR∆exon2 in HeLa cells. RESULTS: FIR was found to repress c-myc transcription and in turn the overexpression of FIR drove apoptosis through c-myc suppression. Thus, FIR expressing vectors are potentially applicable for cancer therapy. FIR is alternatively spliced by SAP155 in cancer cells lacking the transcriptional repression domain within exon 2 (FIR∆exon2), counteracting FIR for c-Myc protein expression. Furthermore, FIR forms a complex with SAP155 and inhibits mutual well-established functions. Thus, both the valuable effects and side effects of exogenous FIR stimuli should be tested for future clinical application. SeV/dF/FIR, a cytoplasmic RNA virus, was successfully prepared and showed highly efficient gene transduction in in vivo experiments. Furthermore, in nude mouse tumor xenograft models, SeV/dF/FIR displayed high antitumor efficiency against human cancer cells. SeV/dF/FIR suppressed SSA-activated c-Myc. SAP155 siRNA, potentially produces FIR∆exon2, and led to c-Myc overexpression with phosphorylation at Ser62. HA-FIR suppressed endogenous c-Myc expression and induced apoptosis in HeLa and SW480 cells. A c-myc transcriptional suppressor FIR expressing SeV/dF/FIR showed high gene transduction efficiency with significant antitumor effects and apoptosis induction in HeLa and SW480 cells. CONCLUSION: SeV/dF/FIR showed strong tumor growth suppression with no significant side effects in an animal xenograft model, thus SeV/dF/FIR is potentially applicable for future clinical cancer treatment. PMID:24764668

Investigation of broadband digital predistortion for broadband radio over fiber transmission systems

NASA Astrophysics Data System (ADS)

Zhang, Xiupu; Liu, Taijun; Shen, Dongya

2016-12-01

In future broadband cloud radio access networks (C-RAN), front-haul transmission systems play a significant role in performance and cost of C-RAN. Broadband and high linearity radio over fiber (RoF) transmission systems are considered a promising solution for the front-haul. Digital linearization is one possible solution for RoF front-haul. In this paper, we investigate RF domain digital predistortion (DPD) linearization for broadband RoF front-haul. The implemented DPD is first investigated in 2.4 GHz WiFi over fiber transmission systems at 36 Mb/s, and more than 8-dB and 5.6-dB improvements of error vector magnitude (EVM) are achieved in back to back (BTB) and after 10 km single mode fiber (SMF) transmission. Further, both WiFi and ultra wide band (UWB) wireless signals are transmitted together, in which the DPD has linearization bandwidth of 2.4 GHz. It is shown that the implemented DPD leads to EVM improvements of 4.5-dB (BTB) and 3.1-dB (10 km SMF) for the WiFi signal, and 4.6-dB (BTB) and 4-dB (10 km SMF) for the broadband UWB signal.

Masses and decay constants of D(s) * and B(s) * mesons with Nf=2 +1 +1 twisted mass fermions

NASA Astrophysics Data System (ADS)

Lubicz, V.; Melis, A.; Simula, S.; ETM Collaboration

2017-08-01

We present a lattice calculation of the masses and decay constants of D(s) * and B(s) * mesons using the gauge configurations produced by the European Twisted Mass Collaboration (ETMC) with Nf=2 +1 +1 dynamical quarks at three values of the lattice spacing a ˜(0.06 -0.09 ) fm . Pion masses are simulated in the range Mπ≃(210 - 450 ) MeV , while the strange and charm sea-quark masses are close to their physical values. We compute the ratios of vector to pseudoscalar masses and decay constants for various values of the heavy-quark mass mh in the range 0.7 mcphys≲mh≲3 mcphys . In order to reach the physical b -quark mass, we exploit the heavy quark effective theory prediction that, in the static limit of infinite heavy-quark mass, the considered ratios are equal to one. At the physical point our results are MD*/MD=1.0769 (79 ) , MDs*/MDs=1.0751(56 ), fD*/fD=1.078 (36 ), fDs*/fD s=1.087 (20 ), MB*/MB=1.0078 (15 ), MBs*/MBs=1.0083(10 ), fB*/fB=0.958 (22 ) and fBs*/fB s=0.974 (10 ). Combining them with the experimental values of the pseudoscalar meson masses (used as input to fix the quark masses) and the values of the pseudoscalar decay constants calculated by ETMC, we get MD*=2013 (14 ), MDs*=2116 (11 ), fD*=223.5 (8.4 ), fDs*=268.8 (6.6 ), MB*=5320.5 (7.6 ), MBs*=5411.36 (5.3 ), fB*=185.9 (7.2 ) and fBs*=223.1 (5.4 ) MeV .

Differential Resonant Ring YIG Tuned Oscillator

NASA Technical Reports Server (NTRS)

Parrott, Ronald A.

2010-01-01

A differential SiGe oscillator circuit uses a resonant ring-oscillator topology in order to electronically tune the oscillator over multi-octave bandwidths. The oscillator s tuning is extremely linear, because the oscillator s frequency depends on the magnetic tuning of a YIG sphere, whose resonant frequency is equal to a fundamental constant times the DC magnetic field. This extremely simple circuit topology uses two coupling loops connecting a differential pair of SiGe bipolar transistors into a feedback configuration using a YIG tuned filter creating a closed-loop ring oscillator. SiGe device technology is used for this oscillator in order to keep the transistor s 1/f noise to an absolute minimum in order to achieve minimum RF phase noise. The single-end resonant ring oscillator currently has an advantage in fewer parts, but when the oscillation frequency is greater than 16 GHz, the package s parasitic behavior couples energy to the sphere and causes holes and poor phase noise performance. This is because the coupling to the YIG is extremely low, so that the oscillator operates at near the unloaded Q. With the differential resonant ring oscillator, the oscillation currents are just in the YIG coupling mechanisms. The phase noise is even better, and the physical size can be reduced to permit monolithic microwave integrated circuit oscillators. This invention is a YIG tuned oscillator circuit making use of a differential topology to simultaneously achieve an extremely broadband electronic tuning range and ultra-low phase noise. As a natural result of its differential circuit topology, all reactive elements, such as tuning stubs, which limit tuning bandwidth by contributing excessive open loop phase shift, have been eliminated. The differential oscillator s open-loop phase shift is associated with completely non-dispersive circuit elements such as the physical angle of the coupling loops, a differential loop crossover, and the high-frequency phase shift of the n-p-n transistors. At the input of the oscillator s feedback loop is a pair of differentially connected n-p-n SiGe transistors that provides extremely high gain, and because they are bulk-effect devices, extremely low 1/f noise (leading to ultralow RF phase noise). The 1/f corner frequency for n-p-n SiGe transistors is approximately 500 Hz. The RF energy from the transistor s collector output is connected directly to the top-coupling loop (the excitation loop) of a single-sphere YIG tuned filter. A uniform magnetic field to bias the YIG must be at a right angle to any vector associated with an RF current in a coupling loop in order for the precession to interact with the RF currents.

Therapeutic levels of fetal hemoglobin in erythroid progeny of β-thalassemic CD34+ cells after lentiviral vector-mediated gene transfer

PubMed Central

Wilber, Andrew; Hargrove, Phillip W.; Kim, Yoon-Sang; Riberdy, Janice M.; Sankaran, Vijay G.; Papanikolaou, Eleni; Georgomanoli, Maria; Anagnou, Nicholas P.; Orkin, Stuart H.; Nienhuis, Arthur W.

2011-01-01

β-Thalassemia major results from severely reduced or absent expression of the β-chain of adult hemoglobin (α2β2;HbA). Increased levels of fetal hemoglobin (α2γ2;HbF), such as occurs with hereditary persistence of HbF, ameliorate the severity of β-thalassemia, raising the potential for genetic therapy directed at enhancing HbF. We used an in vitro model of human erythropoiesis to assay for enhanced production of HbF after gene delivery into CD34+ cells obtained from mobilized peripheral blood of normal adults or steady-state bone marrow from patients with β-thalassemia major. Lentiviral vectors encoding (1) a human γ-globin gene with or without an insulator, (2) a synthetic zinc-finger transcription factor designed to interact with the γ-globin gene promoters, or (3) a short-hairpin RNA targeting the γ-globin gene repressor, BCL11A, were tested. Erythroid progeny of normal CD34+ cells demonstrated levels of HbF up to 21% per vector copy. For β-thalassemic CD34+ cells, similar gene transfer efficiencies achieved HbF production ranging from 45% to 60%, resulting in up to a 3-fold increase in the total cellular Hb content. These observations suggest that both lentiviral-mediated γ-globin gene addition and genetic reactivation of endogenous γ-globin genes have potential to provide therapeutic HbF levels to patients with β-globin deficiency. PMID:21156846

Search for new physics in a precise 20F beta spectrum shape measurement

NASA Astrophysics Data System (ADS)

George, Elizabeth; Voytas, Paul; Chuna, Thomas; Naviliat-Cuncic, Oscar; Gade, Alexandra; Hughes, Max; Huyan, Xueying; Liddick, Sean; Minamisono, Kei; Paulauskas, Stanley; Weisshaar, Dirk; Ban, Gilles; Flechard, Xavier; Lienard, Etienne

2015-10-01

We are carrying out a measurement of the shape of the energy spectrum of β particles from 20F decay. We aim to achieve a relative precision below 3%, representing an order of magnitude improvement compared to previous experiments. This level of precision will enable a test of the so-called strong form of the conserved vector current (CVC) hypothesis, and should also enable us to place competitive limits on the contributions of exotic tensor couplings in beta decay. In order to control systematic effects, we are using a technique that takes advantage of high energy radioactive beams at the NSCL to implant the decaying nuclei in a scintillation detector deep enough that the emitted beta particles cannot escape. The β-particle energy is measured with the implantation detector after switching off the beam implantation. Ancillary detectors are used to tag the 1.633-MeV γ-rays following the β decay for coincidence measurements in order to reduce backgrounds. We will give an overview and report on the status of the experiment.

Delocalized SYZ mirrors and confronting top-down SU(3)-structure holographic meson masses at finite g and N_c with P(article) D(ata) G(roup) values

NASA Astrophysics Data System (ADS)

Yadav, Vikas; Misra, Aalok; Sil, Karunava

2017-10-01

Meson spectroscopy at finite gauge coupling - whereat any perturbative QCD computation would break down - and finite number of colors, from a top-down holographic string model, has thus far been entirely missing in the literature. This paper fills this gap. Using the delocalized type IIA SYZ mirror (with SU(3) structure) of the holographic type IIB dual of large- N thermal QCD of Mia et al. (Nucl Phys B 839:187. arXiv:0902.1540 [hep-th], 2010) as constructed in Dhuria and Misra (JHEP 1311:001. arXiv:1306.4339 [hep-th], 2013) at finite coupling and number of colors (N_c = number of D5(\\overline{D5})-branes wrapping a vanishing two-cycle in the top-down holographic construct of Mia et al. (Nucl Phys B 839:187. arXiv:0902.1540 [hep-th], 2010) = O(1) in the IR in the MQGP limit of Dhuria and Misra (JHEP 1311:001. arXiv:1306.4339 [hep-th], 2013) at the end of a Seiberg-duality cascade), we obtain analytical (not just numerical) expressions for the vector and scalar meson spectra and compare our results with previous calculations of Sakai and Sugimoto (Prog Theor Phys 113:843. doi: 10.1143/PTP.113.843 arXiv:hep-th/0412141, 2005) and Dasgupta et al. (JHEP 1507:122. doi: 10.1007/JHEP07(2015)122 arXiv:1409.0559 [hep-th], 2015), and we obtain a closer match with the Particle Data Group (PDG) results of Olive et al. (Particle Data Group) (Chin Phys C 38:090001, 2014). Through explicit computations, we verify that the vector and scalar meson spectra obtained by the gravity dual with a black hole for all temperatures (small and large) are nearly isospectral with the spectra obtained by a thermal gravity dual valid for only low temperatures; the isospectrality is much closer for vector mesons than scalar mesons. The black-hole gravity dual (with a horizon radius smaller than the deconfinement scale) also provides the expected large- N suppressed decrease in vector meson mass with increase of temperature.

Protective Immunity Against a Lethal Respiratory Yersinia pestis Challenge Induced by V Antigen or the F1 Capsular Antigen Incorporated into Adenovirus Capsid

PubMed Central

Boyer, Julie L.; Sofer-Podesta, Carolina; Ang, John; Hackett, Neil R.; Chiuchiolo, Maria J.; Senina, Svetlana; Perlin, David

2010-01-01

Abstract The aerosol form of the bacterium Yersinia pestis causes pneumonic plague, a rapidly fatal disease that is a biothreat if deliberately released. At present, no plague vaccines are available for use in the United States, but subunit vaccines based on the Y. pestis V antigen and F1 capsular protein show promise when administered with adjuvants. In the context that adenovirus (Ad) gene transfer vectors have a strong adjuvant potential related to the ability to directly infect dendritic cells, we hypothesized that modification of the Ad5 capsid to display either the Y. pestis V antigen or the F1 capsular antigen on the virion surface would elicit high V antigen- or F1-specific antibody titers, permit boosting with the same Ad serotype, and provide better protection against a lethal Y. pestis challenge than immunization with equivalent amounts of V or F1 recombinant protein plus conventional adjuvant. We constructed AdYFP-pIX/V and AdLacZ-pIX/F1, E1–, E3– serotype 5 Ad gene transfer vectors containing a fusion of the sequence for either the Y. pestis V antigen or the F1 capsular antigen to the carboxy-terminal sequence of pIX, a capsid protein that can accommodate the entire V antigen (37 kDa) or F1 protein (15 kDa) without disturbing Ad function. Immunization with AdYFP-pIX/V followed by a single repeat administration of the same vector at the same dose resulted in significantly better protection of immunized animals compared with immunization with a molar equivalent amount of purified recombinant V antigen plus Alhydrogel adjuvant. Similarly, immunization with AdLacZ-pIX/F1 in a prime–boost regimen resulted in significantly enhanced protection of immunized animals compared with immunization with a molar-equivalent amount of purified recombinant F1 protein plus adjuvant. These observations demonstrate that Ad vaccine vectors containing pathogen-specific antigens fused to the pIX capsid protein have strong adjuvant properties and stimulate more robust protective immune responses than equivalent recombinant protein-based subunit vaccines administered with conventional adjuvant, suggesting that F1-and/or V-modified capsid Ad-based recombinant vaccines should be considered for development as anti-plague vaccines. PMID:20180652

Nonlinear Decay of Alfvén Waves Driven by Interplaying Two- and Three-dimensional Nonlinear Interactions

NASA Astrophysics Data System (ADS)

Zhao, J. S.; Voitenko, Y.; De Keyser, J.; Wu, D. J.

2018-04-01

We study the decay of Alfvén waves in the solar wind, accounting for the joint operation of two-dimensional (2D) scalar and three-dimensional (3D) vector nonlinear interactions between Alfvén and slow waves. These interactions have previously been studied separately in long- and short-wavelength limits where they lead to 2D scalar and 3D vector decays, correspondingly. The joined action of the scalar and vector interactions shifts the transition between 2D and 3D decays to significantly smaller wavenumbers than was predicted by Zhao et al. who compared separate scalar and vector decays. In application to the broadband Alfvén waves in the solar wind, this means that the vector nonlinear coupling dominates in the extended wavenumber range 5 × 10‑4 ≲ ρ i k 0⊥ ≲ 1, where the decay is essentially 3D and nonlocal, generating product Alfvén and slow waves around the ion gyroscale. Here ρ i is the ion gyroradius, and k 0⊥ is the pump Alfvén wavenumber. It appears that, except for the smallest wavenumbers at and below {ρ }i{k}0\\perp ∼ {10}-4 in Channel I, the nonlinear decay of magnetohydrodynamic Alfvén waves propagating from the Sun is nonlocal and cannot generate counter-propagating Alfvén waves with similar scales needed for the turbulent cascade. Evaluation of the nonlinear frequency shift shows that product Alfvén waves can still be approximately described as normal Alfvénic eigenmodes. On the contrary, nonlinearly driven slow waves deviate considerably from normal modes and are therefore difficult to identify on the basis of their phase velocities and/or polarization.

Method and system for operating an electric motor

DOEpatents

Gallegos-Lopez, Gabriel; Hiti, Silva; Perisic, Milun

2013-01-22

Methods and systems for operating an electric motor having a plurality of windings with an inverter having a plurality of switches coupled to a voltage source are provided. A first plurality of switching vectors is applied to the plurality of switches. The first plurality of switching vectors includes a first ratio of first magnitude switching vectors to second magnitude switching vectors. A direct current (DC) current associated with the voltage source is monitored during the applying of the first plurality of switching vectors to the plurality of switches. A second ratio of the first magnitude switching vectors to the second magnitude switching vectors is selected based on the monitoring of the DC current associated with the voltage source. A second plurality of switching vectors is applied to the plurality of switches. The second plurality of switching vectors includes the second ratio of the first magnitude switching vectors to the second magnitude switching vectors.

BAAV mediated GJB2 gene transfer restores gap junction coupling in cochlear organotypic cultures from deaf Cx26Sox10Cre mice.

PubMed

Crispino, Giulia; Di Pasquale, Giovanni; Scimemi, Pietro; Rodriguez, Laura; Galindo Ramirez, Fabian; De Siati, Romolo Daniele; Santarelli, Rosa Maria; Arslan, Edoardo; Bortolozzi, Mario; Chiorini, John A; Mammano, Fabio

2011-01-01

The deafness locus DFNB1 contains GJB2, the gene encoding connexin26 and GJB6, encoding connexin30, which appear to be coordinately regulated in the inner ear. In this work, we investigated the expression and function of connexin26 and connexin30 from postnatal day 5 to adult age in double transgenic Cx26(Sox10Cre) mice, which we obtained by crossing connexin26 floxed mice with a deleter Sox10-Cre line. Cx26(Sox10Cre) mice presented with complete connexin26 ablation in the epithelial gap junction network of the cochlea, whereas connexin30 expression was developmentally delayed; immunolabeling patterns for both connexins were normal in the cochlear lateral wall. In vivo electrophysiological measurements in Cx26(Sox10Cre) mice revealed profound hearing loss accompanied by reduction of endocochlear potential, and functional experiments performed in postnatal cochlear organotypic cultures showed impaired gap junction coupling. Transduction of these cultures with a bovine adeno associated virus vector restored connexin26 protein expression and rescued gap junction coupling. These results suggest that restoration of normal connexin levels by gene delivery via recombinant adeno associated virus could be a way to rescue hearing function in DFNB1 mouse models and, in future, lead to the development of therapeutic interventions in humans.

Portal Connecting Dark Photons and Axions.

PubMed

Kaneta, Kunio; Lee, Hye-Sung; Yun, Seokhoon

2017-03-10

The dark photon and the axion (or axionlike particle) are popular light particles of the hidden sector. Each of them has been actively searched for through the couplings called the vector portal and the axion portal. We introduce a new portal connecting the dark photon and the axion (axion-photon-dark photon, axion-dark photon-dark photon), which emerges in the presence of the two particles. This dark axion portal is genuinely new couplings, not just from a product of the vector portal and the axion portal, because of the internal structure of these couplings. We present a simple model that realizes the dark axion portal and discuss why it warrants a rich phenomenology.

Infrared and Raman spectroscopy of [Pb(Zn1/3Nb2/3)O3]0.92-[PbTiO3]0.08 and [Pb(Mg1/3Nb2/3)O3]0.71-[PbTiO3]0.29 single crystals

NASA Astrophysics Data System (ADS)

Kamba, S.; Buixaderas, E.; Petzelt, J.; Fousek, J.; Nosek, J.; Bridenbaugh, P.

2003-01-01

Far-infrared reflectivity spectra of [Pb(Zn1/3Nb2/3)O3]0.92-[PbTiO3]0.08 and [Pb(Mg1/3Nb2/3)O3]0.71-[PbTiO3]0.29 single crystals were investigated between 10 and 530 K, micro-Raman spectra were recorded between 300 and 800 K. No phonon softening was observed near either of the ferroelectric phase transitions. The low-frequency dielectric anomaly in the paraelectric phase is caused by contribution of dynamic polar nanoclusters with the main dispersion in the microwave range. Infrared and Raman spectra confirm the locally doubled unit cell (Zprim=2) in the paraelectric and ferroelectric phases due to the ordering in the perovskite B sites and occurrence of polar nanoclusters in the paraelectric phase. The lowest-frequency transverse optical (TO1) phonon mode active in the infrared spectra is underdamped in contrast to the recent result of inelastic neutron scattering, where no TO1 mode could be observed for the wave vectors q⩽0.2 Å-1. This discrepancy was explained by different q vectors probed in infrared and neutron experiments. The infrared probe couples with very long-wavelength phonons (q≈10-5 Å-1) which see the homogeneous medium averaged over the nanoclusters, whereas the neutron probe couples with phonons whose wavelength is comparable to the nanocluster size (q⩾10-2 Å-1).

Precision determination of the πN scattering lengths and the charged πNN coupling constant

NASA Astrophysics Data System (ADS)

Ericson, T. E. O.; Loiseau, B.; Thomas, A. W.

2000-01-01

We critically evaluate the isovector GMO sumrule for the charged πNN coupling constant using recent precision data from π-p and π-d atoms and with careful attention to systematic errors. From the π-d scattering length we deduce the pion-proton scattering lengths 1/2(aπ-p + aπ-n) = (-20 +/- 6(statistic)+/-10 (systematic) .10-4m-1πc and 1/2(aπ-p - aπ-n) = (903 +/- 14) . 10-4m-1πc. From this a direct evaluation gives g2c(GMO)/4π = 14.20 +/- 0.07 (statistic)+/-0.13(systematic) or f2c/4π = 0.0786 +/- 0.0008.

Computing energy levels of CH4, CHD3, CH3D, and CH3F with a direct product basis and coordinates based on the methyl subsystem.

PubMed

Zhao, Zhiqiang; Chen, Jun; Zhang, Zhaojun; Zhang, Dong H; Wang, Xiao-Gang; Carrington, Tucker; Gatti, Fabien

2018-02-21

Quantum mechanical calculations of ro-vibrational energies of CH 4 , CHD 3 , CH 3 D, and CH 3 F were made with two different numerical approaches. Both use polyspherical coordinates. The computed energy levels agree, confirming the accuracy of the methods. In the first approach, for all the molecules, the coordinates are defined using three Radau vectors for the CH 3 subsystem and a Jacobi vector between the remaining atom and the centre of mass of CH 3 . Euler angles specifying the orientation of a frame attached to CH 3 with respect to a frame attached to the Jacobi vector are used as vibrational coordinates. A direct product potential-optimized discrete variable vibrational basis is used to build a Hamiltonian matrix. Ro-vibrational energies are computed using a re-started Arnoldi eigensolver. In the second approach, the coordinates are the spherical coordinates associated with four Radau vectors or three Radau vectors and a Jacobi vector, and the frame is an Eckart frame. Vibrational basis functions are products of contracted stretch and bend functions, and eigenvalues are computed with the Lanczos algorithm. For CH 4 , CHD 3 , and CH 3 D, we report the first J > 0 energy levels computed on the Wang-Carrington potential energy surface [X.-G. Wang and T. Carrington, J. Chem. Phys. 141(15), 154106 (2014)]. For CH 3 F, the potential energy surface of Zhao et al. [J. Chem. Phys. 144, 204302 (2016)] was used. All the results are in good agreement with experimental data.

Computing energy levels of CH4, CHD3, CH3D, and CH3F with a direct product basis and coordinates based on the methyl subsystem

NASA Astrophysics Data System (ADS)

Zhao, Zhiqiang; Chen, Jun; Zhang, Zhaojun; Zhang, Dong H.; Wang, Xiao-Gang; Carrington, Tucker; Gatti, Fabien

2018-02-01

Quantum mechanical calculations of ro-vibrational energies of CH4, CHD3, CH3D, and CH3F were made with two different numerical approaches. Both use polyspherical coordinates. The computed energy levels agree, confirming the accuracy of the methods. In the first approach, for all the molecules, the coordinates are defined using three Radau vectors for the CH3 subsystem and a Jacobi vector between the remaining atom and the centre of mass of CH3. Euler angles specifying the orientation of a frame attached to CH3 with respect to a frame attached to the Jacobi vector are used as vibrational coordinates. A direct product potential-optimized discrete variable vibrational basis is used to build a Hamiltonian matrix. Ro-vibrational energies are computed using a re-started Arnoldi eigensolver. In the second approach, the coordinates are the spherical coordinates associated with four Radau vectors or three Radau vectors and a Jacobi vector, and the frame is an Eckart frame. Vibrational basis functions are products of contracted stretch and bend functions, and eigenvalues are computed with the Lanczos algorithm. For CH4, CHD3, and CH3D, we report the first J > 0 energy levels computed on the Wang-Carrington potential energy surface [X.-G. Wang and T. Carrington, J. Chem. Phys. 141(15), 154106 (2014)]. For CH3F, the potential energy surface of Zhao et al. [J. Chem. Phys. 144, 204302 (2016)] was used. All the results are in good agreement with experimental data.

Ratios of Vector and Pseudoscalar B Meson Decay Constants in the Light-Cone Quark Model

NASA Astrophysics Data System (ADS)

Dhiman, Nisha; Dahiya, Harleen

2018-05-01

We study the decay constants of pseudoscalar and vector B meson in the framework of light-cone quark model. We apply the variational method to the relativistic Hamiltonian with the Gaussian-type trial wave function to obtain the values of β (scale parameter). Then with the help of known values of constituent quark masses, we obtain the numerical results for the decay constants f_P and f_V, respectively. We compare our numerical results with the existing experimental data.

Intruder Polarization.

DTIC Science & Technology

1985-12-01

mentioned project whose objective was to produce 0DIST~i8LT1,vAAILABILITr OF ABSTRACT 21 ABSTRACT SEC R.ITY CLASSiF CATION ~ .~ C.,NCLASSIFIEDI’.,NLMITED M ...wave propagation vector m . Thl-; -’esns that, f we wnnt to perform the tv-o-lirensional inverse 7’,urier ’ransformar i7! (to transform from i-space...nropaqition vector ~,which was used extensively in the -’-i-al npnro)arh, is still retained in the new approach. It is used in nodellin" m . if

Feature-space-based FMRI analysis using the optimal linear transformation.

PubMed

Sun, Fengrong; Morris, Drew; Lee, Wayne; Taylor, Margot J; Mills, Travis; Babyn, Paul S

2010-09-01

The optimal linear transformation (OLT), an image analysis technique of feature space, was first presented in the field of MRI. This paper proposes a method of extending OLT from MRI to functional MRI (fMRI) to improve the activation-detection performance over conventional approaches of fMRI analysis. In this method, first, ideal hemodynamic response time series for different stimuli were generated by convolving the theoretical hemodynamic response model with the stimulus timing. Second, constructing hypothetical signature vectors for different activity patterns of interest by virtue of the ideal hemodynamic responses, OLT was used to extract features of fMRI data. The resultant feature space had particular geometric clustering properties. It was then classified into different groups, each pertaining to an activity pattern of interest; the applied signature vector for each group was obtained by averaging. Third, using the applied signature vectors, OLT was applied again to generate fMRI composite images with high SNRs for the desired activity patterns. Simulations and a blocked fMRI experiment were employed for the method to be verified and compared with the general linear model (GLM)-based analysis. The simulation studies and the experimental results indicated the superiority of the proposed method over the GLM-based analysis in detecting brain activities.

Wideband helicity dependent spoof surface plasmon polaritons coupling metasurface based on dispersion design.

PubMed

Dong, Guoxiang; Shi, Hongyu; He, Yuchen; Zhang, Anxue; Wei, Xiaoyong; Zhuang, Yongyong; Du, Bai; Xia, Song; Xu, Zhuo

2016-12-06

The surface plasmon polaritons (SPPs) have many potential application due to their local field enhancement and sub-wavelength characteristics. Recently, the gradient metasurface is introduced to couple the spoof SPPs in microwave frequency band. One of the most important issue which should be solved is the narrowband of spoof SPPs coupling on the gradient metasurface. Here, the metasurface is proposed to achieve the wideband helicity dependent directional spoof SPPs coupling for circular polarized light. Our research show that the coupling frequency of spoof SPPs on the gradient metasurface is determined by the dispersion of the metasurface, so the coupling frequency can be controlled by dispersion design. The careful design of each cell geometric parameters has provided many appropriate dispersion relations possessed by just one metasurface. The wave vector matching between the propagating wave and the spoof SPPs has been achieved at several frequencies for certain wave vector provided by the metasurface, which leads to wideband spoof SPPs coupling. This work has shown that wideband helicity dependent directional spoof SPPs coupling has been achieved with a high efficiency. Hence, the proposed wideband spoof SPPs coupling presents the improvement in practice applications.

Wideband helicity dependent spoof surface plasmon polaritons coupling metasurface based on dispersion design

PubMed Central

Dong, Guoxiang; Shi, Hongyu; He, Yuchen; Zhang, Anxue; Wei, Xiaoyong; Zhuang, Yongyong; Du, Bai; Xia, Song; Xu, Zhuo

2016-01-01

The surface plasmon polaritons (SPPs) have many potential application due to their local field enhancement and sub-wavelength characteristics. Recently, the gradient metasurface is introduced to couple the spoof SPPs in microwave frequency band. One of the most important issue which should be solved is the narrowband of spoof SPPs coupling on the gradient metasurface. Here, the metasurface is proposed to achieve the wideband helicity dependent directional spoof SPPs coupling for circular polarized light. Our research show that the coupling frequency of spoof SPPs on the gradient metasurface is determined by the dispersion of the metasurface, so the coupling frequency can be controlled by dispersion design. The careful design of each cell geometric parameters has provided many appropriate dispersion relations possessed by just one metasurface. The wave vector matching between the propagating wave and the spoof SPPs has been achieved at several frequencies for certain wave vector provided by the metasurface, which leads to wideband spoof SPPs coupling. This work has shown that wideband helicity dependent directional spoof SPPs coupling has been achieved with a high efficiency. Hence, the proposed wideband spoof SPPs coupling presents the improvement in practice applications. PMID:27922132

Influence of container design on predation rate of potential biocontrol agent, Toxorhynchites splendens (Diptera: Culicidae) against dengue vector.

PubMed

Mohamad, N; Zuharah, W F

2014-03-01

Toxorhynchites splendens larvae are a natural predator of dengue vector mosquito larvae, Aedes albopictus. This study was carried out to evaluate the predation rate of Tx. splendens third instar larvae on Ae. albopictus larvae in 24 h. Each predator was offered prey at a density between 10 to 50 individuals. Predation rate of Tx. splendens were also tested with two manipulated factors; various types of container and different water volumes. The experiment was evaluated in man-made containers (tin cans, plastic drinking glasses and rubber tires) and natural container (bamboo stumps) which were filled with different water volumes (full, half full, 1/4 full, and 1/8 full). The prey density and the characteristics of the container were found as significant factors which influence the predation rate of Tx. splendens. The predator consumed significantly more prey at higher prey densities (40 and 50 preys) compared to the lowest density (10 preys) (F=3.935, df=4, p=0.008). The results showed significantly higher consumption in horizontal shaped container of rubber tire than in vertical shape of bamboo stumps (F=3.100, df=3, p=0.029). However, the water volume had no significant effect on predation rate of Tx. splendens (F=1.736, df=3, p=0.162). We generally suggest that Tx. splendens is best to be released in discarded tires or any other containers with horizontal shape design with wide opening since Tx. splendens can become more effective in searching prey in this type of container design. This predator is also a suitable biocontrol candidates to be introduced either in wet and dry seasons in Malaysia.

Chern-Simons-matter dualities with SO and USp gauge groups

DOE PAGES

Aharony, Ofer; Benini, Francesco; Hsin, Po -Shen; ...

2017-02-14

In the last few years several dualities were found between the low-energy behaviors of Chern-Simons-matter theories with unitary gauge groups coupled to scalars, and similar theories coupled to fermions. In this paper we generalize those dualities to orthogonal and symplectic gauge groups. In particular, we conjecture dualities between SO(N) k Chern-Simons theories coupled to N f real scalars in the fundamental representation, and SO(k)- N+N f /2 coupled to N f real (Majorana) fermions in the fundamental. For N f = 0 these are just level-rank dualities of pure Chern-Simons theories, whose precise form we clarify. They lead us tomore » propose new gapped boundary states of topological insulators and superconductors. As a result, for k = 1 we get an interesting low-energy duality between N f free Majorana fermions and an SO( N) 1 Chern-Simons theory coupled to N f scalar fields (with N f ≤ N-2).« less

A High Throughput Barley Stripe Mosaic Virus Vector for Virus Induced Gene Silencing in Monocots and Dicots

PubMed Central

Yan, Lijie; Jackson, Andrew O.; Liu, Zhiyong; Han, Chenggui; Yu, Jialin; Li, Dawei

2011-01-01

Barley stripe mosaic virus (BSMV) is a single-stranded RNA virus with three genome components designated alpha, beta, and gamma. BSMV vectors have previously been shown to be efficient virus induced gene silencing (VIGS) vehicles in barley and wheat and have provided important information about host genes functioning during pathogenesis as well as various aspects of genes functioning in development. To permit more effective use of BSMV VIGS for functional genomics experiments, we have developed an Agrobacterium delivery system for BSMV and have coupled this with a ligation independent cloning (LIC) strategy to mediate efficient cloning of host genes. Infiltrated Nicotiana benthamiana leaves provided excellent sources of virus for secondary BSMV infections and VIGS in cereals. The Agro/LIC BSMV VIGS vectors were able to function in high efficiency down regulation of phytoene desaturase (PDS), magnesium chelatase subunit H (ChlH), and plastid transketolase (TK) gene silencing in N. benthamiana and in the monocots, wheat, barley, and the model grass, Brachypodium distachyon. Suppression of an Arabidopsis orthologue cloned from wheat (TaPMR5) also interfered with wheat powdery mildew (Blumeria graminis f. sp. tritici) infections in a manner similar to that of the A. thaliana PMR5 loss-of-function allele. These results imply that the PMR5 gene has maintained similar functions across monocot and dicot families. Our BSMV VIGS system provides substantial advantages in expense, cloning efficiency, ease of manipulation and ability to apply VIGS for high throughput genomics studies. PMID:22031834

Using monomer vibrational wavefunctions to compute numerically exact (12D) rovibrational levels of water dimer

NASA Astrophysics Data System (ADS)

Wang, Xiao-Gang; Carrington, Tucker

2018-02-01

We compute numerically exact rovibrational levels of water dimer, with 12 vibrational coordinates, on the accurate CCpol-8sf ab initio flexible monomer potential energy surface [C. Leforestier et al., J. Chem. Phys. 137, 014305 (2012)]. It does not have a sum-of-products or multimode form and therefore quadrature in some form must be used. To do the calculation, it is necessary to use an efficient basis set and to develop computational tools, for evaluating the matrix-vector products required to calculate the spectrum, that obviate the need to store the potential on a 12D quadrature grid. The basis functions we use are products of monomer vibrational wavefunctions and standard rigid-monomer basis functions (which involve products of three Wigner functions). Potential matrix-vector products are evaluated using the F matrix idea previously used to compute rovibrational levels of 5-atom and 6-atom molecules. When the coupling between inter- and intra-monomer coordinates is weak, this crude adiabatic type basis is efficient (only a few monomer vibrational wavefunctions are necessary), although the calculation of matrix elements is straightforward. It is much easier to use than an adiabatic basis. The product structure of the basis is compatible with the product structure of the kinetic energy operator and this facilitates computation of matrix-vector products. Compared with the results obtained using a [6 + 6]D adiabatic approach, we find good agreement for the inter-molecular levels and larger differences for the intra-molecular water bend levels.

Using monomer vibrational wavefunctions to compute numerically exact (12D) rovibrational levels of water dimer.

PubMed

Wang, Xiao-Gang; Carrington, Tucker

2018-02-21

We compute numerically exact rovibrational levels of water dimer, with 12 vibrational coordinates, on the accurate CCpol-8sf ab initio flexible monomer potential energy surface [C. Leforestier et al., J. Chem. Phys. 137, 014305 (2012)]. It does not have a sum-of-products or multimode form and therefore quadrature in some form must be used. To do the calculation, it is necessary to use an efficient basis set and to develop computational tools, for evaluating the matrix-vector products required to calculate the spectrum, that obviate the need to store the potential on a 12D quadrature grid. The basis functions we use are products of monomer vibrational wavefunctions and standard rigid-monomer basis functions (which involve products of three Wigner functions). Potential matrix-vector products are evaluated using the F matrix idea previously used to compute rovibrational levels of 5-atom and 6-atom molecules. When the coupling between inter- and intra-monomer coordinates is weak, this crude adiabatic type basis is efficient (only a few monomer vibrational wavefunctions are necessary), although the calculation of matrix elements is straightforward. It is much easier to use than an adiabatic basis. The product structure of the basis is compatible with the product structure of the kinetic energy operator and this facilitates computation of matrix-vector products. Compared with the results obtained using a [6 + 6]D adiabatic approach, we find good agreement for the inter-molecular levels and larger differences for the intra-molecular water bend levels.

[The preparation of recombinant adenovirus Ad-Rad50-GFP and detection of the optimal multiplicity of infection in CNE1 transfected hv Ad-Rad50-GFP].

PubMed

Yan, Ruicheng; Huang, Jiancong; Zhu, Ling; Chang, Lihong; Li, Jingjia; Wu, Xifu; Ye, Jin; Zhang, Gehua

2015-12-01

The optimal multiplicity of infection (MOI) of the recombinant adenovirus Ad-Rad50-GFP carrying a mutant Rad50 gene expression region on the cell growth of nasopharyngeal carcinoma and the viral amplification efficiency of CNE1 cell infected by this adenovirus were studied. The biological titer of Ad-Rad50-GFP was measured by end point dilution method. The impact of recombinant adenoviral vector transfection on the growth of CNE1 cells was observed by cell growth curve. Transfection efficacy of recombinant adenoviral vector was observed and calculated through fluorescence microscope. The expression f mutant Rad50 in the Ad-Rad50-GFP transfected CNE1 cells with optimal MOI was detected by Western Blot after transfection. The biological titer of Ad-Rad50-GFP was 1.26 x 10¹¹ pfu/ml. CNE1 cell growth was not influenced significantly as they were transfected by recombinant adenoviral vector with MOI less than 50. Transfection efficacy of recombinant adenoviral vector was most salient at 24 hours after transfection, with the high expression of mutant Rad50, and the efficiency still remained about 70% after 72 hours. Recombinant adenoviral vector Ad-Rad50-GFP could transfect CNE1 cells as well as result in the expression of mutant Rad50 in CNE1 cells effectively. MOI = 50 was the optimal multiplicity of infection of CNE1 cells transfected by recombinant adenoviral vector Ad-Rad50-GFP.

EwE-F 1.0: an implementation of Ecopath with Ecosim in Fortran 95/2003 for coupling and integration with other models

NASA Astrophysics Data System (ADS)

Akoglu, E.; Libralato, S.; Salihoglu, B.; Oguz, T.; Solidoro, C.

2015-08-01

Societal and scientific challenges foster the implementation of the ecosystem approach to marine ecosystem analysis and management, which is a comprehensive means of integrating the direct and indirect effects of multiple stressors on the different components of ecosystems, from physical to chemical and biological and from viruses to fishes and marine mammals. Ecopath with Ecosim (EwE) is a widely used software package, which offers capability for a dynamic description of the multiple interactions occurring within a food web, and, potentially, a crucial component of an integrated platform supporting the ecosystem approach. However, being written for the Microsoft .NET framework, seamless integration of this code with Fortran-based physical and/or biogeochemical oceanographic models is technically not straightforward. In this work we release a re-coding of EwE in Fortran (EwE-F). We believe that the availability of a Fortran version of EwE is an important step towards setting up coupled/integrated modelling schemes utilising this widely adopted software because it (i) increases portability of the EwE models and (ii) provides additional flexibility towards integrating EwE with Fortran-based modelling schemes. Furthermore, EwE-F might help modellers using the Fortran programming language to get close to the EwE approach. In the present work, first fundamentals of EwE-F are introduced, followed by validation of EwE-F against standard EwE utilising sample models. Afterwards, an end-to-end (E2E) ecological representation of the Gulf of Trieste (northern Adriatic Sea) ecosystem is presented as an example of online two-way coupling between an EwE-F food web model and a biogeochemical model. Finally, the possibilities that having EwE-F opens up are discussed.

Retrofitting BACs with G418 resistance, luciferase, and oriP and EBNA-1 – new vectors for in vitro and in vivo delivery

PubMed Central

Magin-Lachmann, Christine; Kotzamanis, George; D'Aiuto, Leonardo; Wagner, Ernst; Huxley, Clare

2003-01-01

Background Bacterial artificial chromosomes (BACs) have been used extensively for sequencing the human and mouse genomes and are thus readily available for most genes. The large size of BACs means that they can generally carry intact genes with all the long range controlling elements that drive full levels of tissue-specific expression. For gene expression studies and gene therapy applications it is useful to be able to retrofit the BACs with selectable genes such as G418 resistance, reporter genes such as luciferase, and oriP/EBNA-1 from Epstein Barr virus which allows long term episomal maintenance in mammalian cells. Results We describe a series of retrofitting plasmids and a protocol for in vivo loxP/Cre recombination. The vector pRetroNeo carries a G418 resistance cassette, pRetroNeoLuc carries G418 resistance and a luciferase expression cassette, pRetroNeoLucOE carries G418 resistance, luciferase and an oriP/EBNA-1 cassette and pRetroNeoOE carries G418 resistance and oriP/EBNA-1. These vectors can be efficiently retrofitted onto BACs without rearrangement of the BAC clone. The luciferase cassette is expressed efficiently from the retrofitting plasmids and from retrofitted BACs after transient transfection of B16F10 cells in tissue culture and after electroporation into muscles of BALB/c mice in vivo. We also show that a BAC carrying GFP, oriP and EBNA-1 can be transfected into B16F10 cells with Lipofectamine 2000 and can be rescued intact after 5 weeks. Conclusion The pRetro vectors allow efficient retrofitting of BACs with G418 resistance, luciferase and/or oriP/EBNA-1 using in vivo expression of Cre. The luciferase reporter gene is expressed after transient transfection of retrofitted BACs into cells in tissue culture and after electroporation into mouse muscle in vivo. OriP/EBNA-1 allows stable maintenance of a 150-kb BAC without rearrangement for at least 5 weeks. PMID:12609052

Dynamically SUSY breaking SQCD on F-theory seven-branes

NASA Astrophysics Data System (ADS)

Buchbinder, Evgeny I.

2008-09-01

We study how dynamically breaking SQCD can be obtained on two intersecting seven-branes in F-theory. In the mechanism which we present in this paper one of the seven-branes is responsible for producing the low-energy gauge group and the other one is for generating vector bundle moduli. The fundamental matter charged under the gauge group is localized on the intersection. The mass of the matter fields is controlled by the vector bundle moduli. The analysis of under what conditions a sufficient number of the fundamental flavors becomes light turns out to be equivalent to the analysis of non-perturbative superpotentials for vector bundle moduli in Heterotic M-theory. We give an example in which we present an explicit equation in the moduli space whose zero locus corresponds to the fundamental fields becoming light. This allows us to provide a local F-theory realization of massive Script N = 1, SU(Nc) SQCD in the free magnetic range which dynamically breaks supersymmetry.

Generation of Elliptically Polarized Terahertz Waves from Antiferromagnetic Sandwiched Structure.

PubMed

Zhou, Sheng; Zhang, Qiang; Fu, Shu-Fang; Wang, Xuan-Zhang; Song, Yu-Ling; Wang, Xiang-Guang; Qu, Xiu-Rong

2018-04-01

The generation of elliptically polarized electromagnetic wave of an antiferromagnetic (AF)/dielectric sandwiched structure in the terahertz range is studied. The frequency and external magnetic field can change the AF optical response, resulting in the generation of elliptical polarization. An especially useful geometry with high levels of the generation of elliptical polarization is found in the case where an incident electromagnetic wave perpendicularly illuminates the sandwiched structure, the AF anisotropy axis is vertical to the wave-vector and the external magnetic field is pointed along the wave-vector. In numerical calculations, the AF layer is FeF2 and the dielectric layers are ZnF2. Although the effect originates from the AF layer, it can be also influenced by the sandwiched structure. We found that the ZnF2/FeF2/ZnF2 structure possesses optimal rotation of the principal axis and ellipticity, which can reach up to about thrice that of a single FeF2 layer.

Integrated Dual Imaging Detector

NASA Technical Reports Server (NTRS)

Rust, David M.

1999-01-01

A new type of image detector was designed to simultaneously analyze the polarization of light at all picture elements in a scene. The integrated Dual Imaging detector (IDID) consists of a lenslet array and a polarizing beamsplitter bonded to a commercial charge coupled device (CCD). The IDID simplifies the design and operation of solar vector magnetographs and the imaging polarimeters and spectroscopic imagers used, for example, in atmosphere and solar research. When used in a solar telescope, the vector magnetic fields on the solar surface. Other applications include environmental monitoring, robot vision, and medical diagnoses (through the eye). Innovations in the IDID include (1) two interleaved imaging arrays (one for each polarization plane); (2) large dynamic range (well depth of 10(exp 5) electrons per pixel); (3) simultaneous readout and display of both images; and (4) laptop computer signal processing to produce polarization maps in field situations.

Vector/Matrix Quantization for Narrow-Bandwidth Digital Speech Compression.

DTIC Science & Technology

1982-09-01

8217o 0 -X -u -vc "oi ’" o 0 00i MN nM I -r -: I I Ir , I C 64 ut c 4c -C ;6 19I *~I C’ I I I 1 Kall 9 I I V4 S.0 M r4) ** al Iw* 0 0 10* 0 f 65 signal...Prediction of the Speech Wave, JASA Vol. 50, pp. 637-655, April 1971 . - 2. I. Itakura and S. Saito, Analysis Synthesis Telephony Based Upon the Maximum

A Numerical Study of Wind Forcing in the Eastern Boundary Current System Off Portugal

DTIC Science & Technology

1989-09-01

foLg’()e "v, [22] where I is the y component of the wave number vector and i= % -1 . The above integral can he discretizd as 26 X([ = Lg’ expL -i 2...fIot and the core of the equatorward surface jet may 65 T FEILD a’ Coy 30 at y =51,2 rn 5𔃼 44 9 324. 255 192 5A 6 82 -. 20 -1920 _ 10 -- 220 4 -2720

Optically Generated 2-Dimensional Photonic Cluster State from Coupled Quantum Dots

DTIC Science & Technology

2010-03-12

coupled quantum dots 5a. CONTRACT NUMBER 5b. GRANT NUMBER 5c. PROGRAM ELEMENT NUMBER 6. AUTHOR( S ) 5d. PROJECT NUMBER 5e. TASK NUMBER 5f. WORK UNIT...NUMBER 7. PERFORMING ORGANIZATION NAME( S ) AND ADDRESS(ES) Naval Research Laboratory,,Washington,DC,20375 8. PERFORMING ORGANIZATION REPORT NUMBER...9. SPONSORING/MONITORING AGENCY NAME( S ) AND ADDRESS(ES) 10. SPONSOR/MONITOR’S ACRONYM( S ) 11. SPONSOR/MONITOR’S REPORT NUMBER( S ) 12. DISTRIBUTION

1/f noise in semiconductor and metal nanocrystal solids

DOE Office of Scientific and Technical Information (OSTI.GOV)

Liu, Heng, E-mail: leophy@gmail.com; Lhuillier, Emmanuel, E-mail: emmanuel.lhuillier@espci.fr; Guyot-Sionnest, Philippe

2014-04-21

Electrical 1/f noise is measured in thin films of CdSe, CdSe/CdS, ZnO, HgTe quantum dots and Au nanocrystals. The 1/f noise, normalized per nanoparticle, shows no systematic dependence on the nanoparticle material and the coupling material. However, over 10 orders of magnitude, it correlates well with the nearest neighbor conductance suggesting some universal magnitude of the 1/f noise in these granular conductors. In the hopping regime, the main mechanism of 1/f noise is determined to be mobility fluctuated. In the metallic regime obtained with gold nanoparticle films, the noise drops to a similar level as bulk gold films and withmore » a similar temperature dependence.« less

Probing anomalous $$ t\\overline{t}Z $$ interactions with rare meson decays

DOE PAGES

Brod, Joachim; Greljo, Admir; Stamou, Emmanuel; ...

2015-02-23

Anomalous couplings of the Z boson to top quarks are only marginally constrained by direct searches and are still sensitive to new particle dynamics at the TeV scale. Employing an effective field theory approach we consider the dimension-six operators which generate deviations from the standard-model vector and axial-vector interactions. We show that rare B and K meson decays together with electroweak precision observables provide strong constraints on these couplings. In addition, we also consider constraints from t-channel single-top production.

A vector-dyadic development of the equations of motion for N-coupled rigid bodies and point masses

NASA Technical Reports Server (NTRS)

Frisch, H. P.

1974-01-01

The equations of motion are derived, in vector-dyadic format, for a topological tree of coupled rigid bodies, point masses, and symmetrical momentum wheels. These equations were programmed, and form the basis for the general-purpose digital computer program N-BOD. A complete derivation of the equations of motion is included along with a description of the methods used for kinematics, constraint elimination, and for the inclusion of nongyroscope forces and torques acting external or internal to the system.

Baryon chiral perturbation theory combined with the 1 /Nc expansion in SU(3): Framework

NASA Astrophysics Data System (ADS)

Fernando, I. P.; Goity, J. L.

2018-03-01

Baryon chiral perturbation theory combined with the 1 /Nc expansion is implemented for three flavors. Baryon masses, vector charges and axial vector couplings are studied to one-loop and organized according to the ξ -expansion, in which the 1 /Nc and the low-energy power countings are linked according to 1 /Nc=O (ξ )=O (p ). The renormalization to O (ξ3) necessary for the mentioned observables is provided, along with applications to the baryon masses and axial couplings as obtained in lattice QCD calculations.

Role of the antiferromagnetic pinning layer on spin wave properties in IrMn/NiFe based spin-valves

DOE Office of Scientific and Technical Information (OSTI.GOV)

Gubbiotti, G., E-mail: gubbiotti@fisica.unipg.it; Tacchi, S.; Del Bianco, L.

2015-05-07

Brillouin light scattering (BLS) was exploited to study the spin wave properties of spin-valve (SV) type samples basically consisting of two 5 nm-thick NiFe layers (separated by a Cu spacer of 5 nm), differently biased through the interface exchange coupling with an antiferromagnetic IrMn layer. Three samples were investigated: a reference SV sample, without IrMn (reference); one sample with an IrMn underlayer (10 nm thick) coupled to the bottom NiFe film; one sample with IrMn underlayer and overlayer of different thickness (10 nm and 6 nm), coupled to the bottom and top NiFe film, respectively. The exchange coupling with the IrMn, causing the insurgence ofmore » the exchange bias effect, allowed the relative orientation of the NiFe magnetization vectors to be controlled by an external magnetic field, as assessed through hysteresis loop measurements by magneto-optic magnetometry. Thus, BLS spectra were acquired by sweeping the magnetic field so as to encompass both the parallel and antiparallel alignment of the NiFe layers. The BLS results, well reproduced by the presented theoretical model, clearly revealed the combined effects on the spin dynamic properties of the dipolar interaction between the two NiFe films and of the interface IrMn/NiFe exchange coupling.« less

A Progression of Static Equilibrium Laboratory Exercises

NASA Astrophysics Data System (ADS)

Kutzner, Mickey; Kutzner, Andrew

2013-10-01

Although simple architectural structures like bridges, catwalks, cantilevers, and Stonehenge have been integral in human societies for millennia, as have levers and other simple tools, modern students of introductory physics continue to grapple with Newton's conditions for static equilibrium. As formulated in typical introductory physics textbooks, these two conditions appear as ΣF=0(1) and Στ=0,(2) where each torque τ is defined as the cross product between the lever arm vector r and the corresponding applied force F, τ =r×F,(3) having magnitude, τ =Frsinθ.(4) The angle θ here is between the two vectors F and r. In Eq. (1), upward (downward) forces are considered positive (negative). In Eq. (2), counterclockwise (clockwise) torques are considered positive (negative). Equation (1) holds that the vector sum of the external forces acting on an object must be zero to prevent linear accelerations; Eq. (2) states that the vector sum of torques due to external forces about any axis must be zero to prevent angular accelerations. In our view these conditions can be problematic for students because a) the equations contain the unfamiliar summation notation Σ, b) students are uncertain of the role of torques in causing rotations, and c) it is not clear why the sum of torques is zero regardless of the choice of axis. Gianino5 describes an experiment using MBL and a force sensor to convey the meaning of torque as applied to a rigid-body lever system without exploring quantitative aspects of the conditions for static equilibrium.

B→πll Form Factors for New Physics Searches from Lattice QCD.

PubMed

Bailey, Jon A; Bazavov, A; Bernard, C; Bouchard, C M; DeTar, C; Du, Daping; El-Khadra, A X; Freeland, E D; Gámiz, E; Gottlieb, Steven; Heller, U M; Kronfeld, A S; Laiho, J; Levkova, L; Liu, Yuzhi; Lunghi, E; Mackenzie, P B; Meurice, Y; Neil, E; Qiu, Si-Wei; Simone, J N; Sugar, R; Toussaint, D; Van de Water, R S; Zhou, Ran

2015-10-09

The rare decay B→πℓ^{+}ℓ^{-} arises from b→d flavor-changing neutral currents and could be sensitive to physics beyond the standard model. Here, we present the first ab initio QCD calculation of the B→π tensor form factor f_{T}. Together with the vector and scalar form factors f_{+} and f_{0} from our companion work [J. A. Bailey et al., Phys. Rev. D 92, 014024 (2015)], these parametrize the hadronic contribution to B→π semileptonic decays in any extension of the standard model. We obtain the total branching ratio BR(B^{+}→π^{+}μ^{+}μ^{-})=20.4(2.1)×10^{-9} in the standard model, which is the most precise theoretical determination to date, and agrees with the recent measurement from the LHCb experiment [R. Aaij et al., J. High Energy Phys. 12 (2012) 125].

$$B\\to\\pi\\ell\\ell$$ Form Factors for New-Physics Searches from Lattice QCD

DOE PAGES

Bailey, Jon A.

2015-10-07

The rare decay B→πℓ +ℓ - arises from b→d flavor-changing neutral currents and could be sensitive to physics beyond the standard model. Here, we present the first ab initio QCD calculation of the B→π tensor form factor f T. Together with the vector and scalar form factors f + and f 0 from our companion work [J. A. Bailey et al., Phys. Rev. D 92, 014024 (2015)], these parametrize the hadronic contribution to B→π semileptonic decays in any extension of the standard model. We obtain the total branching ratio BR(B +→π +μ +μ -)=20.4(2.1)×10 -9 in the standard model, whichmore » is the most precise theoretical determination to date, and agrees with the recent measurement from the LHCb experiment [R. Aaij et al., J. High Energy Phys. 12 (2012) 125].« less

Two novel motion-based algorithms for surveillance video analysis on embedded platforms

NASA Astrophysics Data System (ADS)

Vijverberg, Julien A.; Loomans, Marijn J. H.; Koeleman, Cornelis J.; de With, Peter H. N.

2010-05-01

This paper proposes two novel motion-vector based techniques for target detection and target tracking in surveillance videos. The algorithms are designed to operate on a resource-constrained device, such as a surveillance camera, and to reuse the motion vectors generated by the video encoder. The first novel algorithm for target detection uses motion vectors to construct a consistent motion mask, which is combined with a simple background segmentation technique to obtain a segmentation mask. The second proposed algorithm aims at multi-target tracking and uses motion vectors to assign blocks to targets employing five features. The weights of these features are adapted based on the interaction between targets. These algorithms are combined in one complete analysis application. The performance of this application for target detection has been evaluated for the i-LIDS sterile zone dataset and achieves an F1-score of 0.40-0.69. The performance of the analysis algorithm for multi-target tracking has been evaluated using the CAVIAR dataset and achieves an MOTP of around 9.7 and MOTA of 0.17-0.25. On a selection of targets in videos from other datasets, the achieved MOTP and MOTA are 8.8-10.5 and 0.32-0.49 respectively. The execution time on a PC-based platform is 36 ms. This includes the 20 ms for generating motion vectors, which are also required by the video encoder.

The elusive role of the SPRY2 domain in RyR1

PubMed Central

Willemse, Hermia; Mirza, Shamaruh; Gallant, Esther M; Board, Philip G

2011-01-01

The second of three SPRY domains (SPRY2, S1085-V1208) located in the skeletal muscle ryanodine receptor (RyR1) is contained within regions of RyR1 that influence EC coupling and bind to imperatoxin A, a toxin probe of RyR1 channel gating. We examined the binding of the F loop (P1107-A1121) in SPRY2 to the ASI/basic region in RyR1 (T3471-G3500, containing both alternatively spliced (ASI) residues and neighboring basic amino acids). We then investigated the possible influence of this interaction on excitation contraction (EC) coupling. A peptide with the F loop sequence and an antibody to the SPRY2 domain each enhanced RyR1 activity at low concentrations and inhibited at higher concentrations. A peptide containing the ASI/basic sequence bound to SPRY2 and binding decreased ∼10-fold following mutation or structural disruption of the basic residues. Binding was abolished by mutation of three critical acidic F loop residues. Together these results suggest that the ASI/basic and SPRY2 domains interact in an F loop regulatory module. Although a region that includes the SPRY2 domain influences EC coupling, as does the ASI/basic region, Ca2+ release during ligand- and depolarization-induced RyR1 activation were not altered by mutation of the three critical F loop residues following expression of mutant RyR1 in RyR1-null myotubes. Therefore the electrostatic regulatory interaction between the SPRY2 F loop residues (that bind to imperatoxin A) and the ASI/basic residues of RyR1 does not influence bi-directional DHPR-RyR1 signaling during skeletal EC coupling, possibly because the interaction is interrupted by the influence of factors present in intact muscle cells. PMID:21239886

Remote beating of parallel or orthogonally polarized dual-wavelength optical carriers for 5G millimeter-wave radio-over-fiber link.

PubMed

Wang, Huai-Yung; Chi, Yu-Chieh; Lin, Gong-Ru

2016-08-08

A novel millimeter-wave radio over fiber (MMW-RoF) link at carrier frequency of 35-GHz is proposed with the use of remotely beating MMW generation from reference master and injected slave colorless laser diode (LD) carriers at orthogonally polarized dual-wavelength injection-locking. The slave colorless LD supports lasing one of the dual-wavelength master modes with orthogonal polarizations, which facilitates the single-mode direct modulation of the quadrature amplitude modulation (QAM) orthogonal frequency division multiplexing (OFDM) data. Such an injected single-carrier encoding and coupled dual-carrier transmission with orthogonal polarization effectively suppresses the cross-heterodyne mode-beating intensity noise, the nonlinear modulation (NLM) and four-wave mixing (FWM) sidemodes during injection locking and fiber transmission. In 25-km single-mode fiber (SMF) based wireline system, the dual-carrier under single-mode encoding provides baseband 24-Gbit/s 64-QAM OFDM transmission with an error vector magnitude (EVM) of 8.8%, a bit error rate (BER) of 3.7 × 10^-3, a power penalty of <1.5 dB. After remotely self-beating for wireless transmission, the beat MMW carrier at 35 GHz can deliver the passband 16-QAM OFDM at 4 Gbit/s to show corresponding EVM and BER of 15.5% and 1.4 × 10^-3, respectively, after 25-km SMF and 1.6-m free-space transmission.

1.5-V-threshold-voltage Schottky barrier normally-off AlGaN/GaN high-electron-mobility transistors with f T/f max of 41/125 GHz

NASA Astrophysics Data System (ADS)

Hou, Bin; Ma, Xiaohua; Yang, Ling; Zhu, Jiejie; Zhu, Qing; Chen, Lixiang; Mi, Minhan; Zhang, Hengshuang; Zhang, Meng; Zhang, Peng; Zhou, Xiaowei; Hao, Yue

2017-07-01

In this paper, a normally-off AlGaN/GaN high-electron-mobility transistors (HEMT) fabricated using inductively coupled plasma (ICP) CF4 plasma recessing and an implantation technique is reported. A gate-to-channel distance of ˜10 nm and an equivalent negative fluorine sheet charge density of -1.21 × 1013 cm-2 extracted using a simple threshold voltage (V th) analytical model result in a high V th of 1.5 V, a peak transconductance of 356 mS/mm, and a subthreshold slope of 133 mV/decade. A small degradation of channel mobility leads to a high RF performance with f T/f max of 41/125 GHz, resulting in a record high f T × L g product of 10.66 GHz·µm among Schottky barrier AlGaN/GaN normally-off HEMTs with V th exceeding 1 V, to the best of our knowledge.

Exploiting translational coupling for the selection of cells producing toxic recombinant proteins from expression vectors.

PubMed

Tagliavia, Marcello; Cuttitta, Angela

2016-01-01

High rates of plasmid instability are associated with the use of some expression vectors in Escherichia coli, resulting in the loss of recombinant protein expression. This is due to sequence alterations in vector promoter elements caused by the background expression of the cloned gene, which leads to the selection of fast-growing, plasmid-containing cells that do not express the target protein. This phenomenon, which is worsened when expressing toxic proteins, results in preparations containing very little or no recombinant protein, or even in clone loss; however, no methods to prevent loss of recombinant protein expression are currently available. We have exploited the phenomenon of translational coupling, a mechanism of prokaryotic gene expression regulation, in order to select cells containing plasmids still able to express recombinant proteins. Here we designed an expression vector in which the cloned gene and selection marker are co-expressed. Our approach allowed for the selection of the recombinant protein-expressing cells and proved effective even for clones encoding toxic proteins.

Direct biosensor detection of botulinum neurotoxin endopeptidase activity in sera from patients with type A botulism.

PubMed

Lévêque, Christian; Ferracci, Géraldine; Maulet, Yves; Mazuet, Christelle; Popoff, Michel; Seagar, Michael; El Far, Oussama

2014-07-15

Botulinum neurotoxin A (BoNT/A) has intrinsic endoprotease activity specific for SNAP-25, a key protein for presynaptic neurotransmitter release. The inactivation of SNAP-25 by BoNT/A underlies botulism, a rare but potentially fatal disease. There is a crucial need for a rapid and sensitive in vitro serological test for BoNT/A to replace the current in vivo mouse bioassay. Cleavage of SNAP-25 by BoNT/A generates neo-epitopes which can be detected by binding of a monoclonal antibody (mAb10F12) and thus measured by surface plasmon resonance (SPR). We have explored two SPR assay formats, with either mAb10F12 or His6-SNAP-25 coupled to the biosensor chip. When BoNT/A was incubated with SNAP-25 in solution and the reaction products were captured on a mAb-coated chip, a sensitivity of 5 fM (0.1LD50/ml serum) was obtained. However, this configuration required prior immunoprecipitation of BoNT/A. A sensitivity of 0.5 fM in 10% serum (0.1 LD50/ml serum) was attained when SNAP-25 was coupled directly to the chip, followed by sequential injection of BoNT/A samples and mAb10F12 into the flow system to achieve on-chip cleavage and detection, respectively. This latter format detected BoNT/A endoprotease activity in 50-100 µl serum samples from all patients (11/11) with type A botulism within 5h. No false positives occurred in sera from healthy subjects or patients with other neurological diseases. The automated chip-based procedure has excellent specificity and sensitivity, with significant advantages over the mouse bioassay in terms of rapidity, required sample volume and animal ethics. Copyright © 2014 Elsevier B.V. All rights reserved.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Lello, Louis; Boyanovsky, Daniel; Pisarski, Robert D.

Here, in the standard model extended with a seesaw mass matrix, we study the production of sterile neutrinos from the decay of vector bosons at temperatures near the masses of the electroweak bosons. We derive a general quantum kinetic equation for the production of sterile neutrinos and their effective mixing angles, which is applicable over a wide range of temperature, to all orders in interactions of the standard model and to leading order in a small mixing angle for the neutrinos. We emphasize the relation between the production rate and Landau damping at one-loop order and show that production rates and effective mixing angles depend sensitively upon the neutrino’s helicity. Sterile neutrinos with positive helicity interact more weakly with the medium than those with negative helicity, and their effective mixing angle is not modified significantly. Negative helicity states couple more strongly to the vector bosons, but their mixing angle is strongly suppressed by the medium. Consequently, if the mass of the sterile neutrino is ≲ 8.35 MeV , there are fewer states with negative helicity produced than those with positive helicity. There is an Mikheyev-Smirnov-Wolfenstein-type resonance in the absence of lepton asymmetry, but due to screening by the damping rate, the production rate is not enhanced. Sterile neutrinos with negative helicity freeze out at Tmore » $$-\\atop{f}$$ ≃ 5 GeV , whereas positive helicity neutrinos freeze out at T$$+\\atop{f}$$≃ 8 GeV , with both distributions far from thermal. As the temperature decreases, due to competition between a decreasing production rate and an increasing mixing angle, the distribution function for states with negative helicity is broader in momentum and hotter than that for those with positive helicity. Sterile neutrinos produced via vector boson decay do not satisfy the abundance, lifetime, and cosmological constraints to be the sole dark matter component in the Universe. Massive sterile neutrinos produced via vector boson decay might solve the 7Li problem, albeit at the very edge of the possible parameter space. A heavy sterile neutrino with a mass of a few MeV could decay into light sterile neutrinos, of a few keV in mass, that contribute to warm dark matter. In conclusion, we argue that heavy sterile neutrinos with lifetime ≤1/H 0 reach local thermodynamic equilibrium.« less

Search for vector mediator of dark matter production in invisible decay mode

NASA Astrophysics Data System (ADS)

Banerjee, D.; Burtsev, V. E.; Chumakov, A. G.; Cooke, D.; Crivelli, P.; Depero, E.; Dermenev, A. V.; Donskov, S. V.; Dubinin, F.; Dusaev, R. R.; Emmenegger, S.; Fabich, A.; Frolov, V. N.; Gardikiotis, A.; Gerassimov, S. G.; Gninenko, S. N.; Hösgen, M.; Karneyeu, A. E.; Ketzer, B.; Kirpichnikov, D. V.; Kirsanov, M. M.; Konorov, I. V.; Kovalenko, S. G.; Kramarenko, V. A.; Kravchuk, L. V.; Krasnikov, N. V.; Kuleshov, S. V.; Lyubovitskij, V. E.; Lysan, V.; Matveev, V. A.; Mikhailov, Yu. V.; Peshekhonov, D. V.; Polyakov, V. A.; Radics, B.; Rojas, R.; Rubbia, A.; Samoylenko, V. D.; Tikhomirov, V. O.; Tlisov, D. A.; Toropin, A. N.; Trifonov, A. Yu.; Vasilishin, B. I.; Vasquez Arenas, G.; Ulloa, P.; NA64 Collaboration

2018-04-01

A search is performed for a new sub-GeV vector boson (A') mediated production of dark matter (χ ) in the fixed-target experiment, NA64, at the CERN SPS. The A', called dark photon, can be generated in the reaction e-Z →e-Z A' of 100 GeV electrons dumped against an active target followed by its prompt invisible decay A'→χ χ ¯. The experimental signature of this process would be an event with an isolated electron and large missing energy in the detector. From the analysis of the data sample collected in 2016 corresponding to 4.3 ×1010 electrons on target no evidence of such a process has been found. New stringent constraints on the A' mixing strength with photons, 10-5≲ɛ ≲10-2, for the A' mass range mA'≲1 GeV are derived. For models considering scalar and fermionic thermal dark matter interacting with the visible sector through the vector portal the 90% C.L. limits 10-11≲y ≲10-6 on the dark-matter parameter y =ɛ2αD(m/χmA')4 are obtained for the dark coupling constant αD=0.5 and dark-matter masses 0.001 ≲mχ≲0.5 GeV . The lower limits αD≳10-3 for pseudo-Dirac dark matter in the mass region mχ≲0.05 GeV are more stringent than the corresponding bounds from beam dump experiments. The results are obtained by using exact tree level calculations of the A' production cross sections, which turn out to be significantly smaller compared to the one obtained in the Weizsäcker-Williams approximation for the mass region mA'≳0.1 GeV .

AAV2 production with optimized N/P ratio and PEI-mediated transfection results in low toxicity and high titer for in vitro and in vivo applications.

PubMed

Huang, Xinping; Hartley, Antja-Voy; Yin, Yishi; Herskowitz, Jeremy H; Lah, James J; Ressler, Kerry J

2013-11-01

The adeno-associated virus (AAV) is one of the most useful viral vectors for gene delivery for both in vivo and in vitro applications. A variety of methods have been established to produce and characterize recombinant AAV (rAAV) vectors; however most methods are quite cumbersome and obtaining consistently high titer can be problematic. This protocol describes a triple-plasmid co-transfection approach with 25 kDa linear polyethylenimine (PEI) in 293 T cells for the production of AAV serotype 2. Seventy-two hours post-transfection, supernatant and cells were harvested and purified by a discontinuous iodixanol density gradient ultracentrifugation, then dialyzed and concentrated with an Amicon 15 100,000 MWCO concentration unit. To optimize the protocol for AAV2 production using PEI, various N/P ratios and DNA amounts were compared. We found that an N/P ratio of 40 coupled with 1.05 μg DNA per ml of media (21 μg DNA/15 cm dish) was found to produce the highest yields for viral replication and assembly measured multiple ways. The infectious units, as determined by serial dilution, were between 1×10(8) and 2×10(9) IU/ml. The genomic titer of the viral stock was determined by qPCR and ranged from 2×10(12) to 6×10(13) VG/ml. These viral vectors showed high expression both in vivo within the brain and in vitro in cell culture. The use of linear 25 kDa polyethylenamine PEI as a transfection reagent is a simple, more cost-effective, and stable means of high-throughput production of high-titer AAV serotype 2. The use of PEI also eliminates the need to change cell medium post-transfection, lowering cost and workload, while producing high-titer, efficacious AAV2 vectors for routine gene transfer. Copyright © 2013 Elsevier B.V. All rights reserved.

MISR Level 3 Cloud Motion Vector

Atmospheric Science Data Center

2013-07-10

... 2012 A new version, F02_0002, of the MISR L3 CMV (Cloud Motion Vector) data product is now available. This new release ... CMV products for the full mission time period of March 2000 - September 2012 are now available for ordering.   Information ...

Packaging and Prefusion Stabilization Separately and Additively Increase the Quantity and Quality of Respiratory Syncytial Virus (RSV)-Neutralizing Antibodies Induced by an RSV Fusion Protein Expressed by a Parainfluenza Virus Vector.

PubMed

Liang, Bo; Ngwuta, Joan O; Herbert, Richard; Swerczek, Joanna; Dorward, David W; Amaro-Carambot, Emerito; Mackow, Natalie; Kabatova, Barbora; Lingemann, Matthias; Surman, Sonja; Yang, Lijuan; Chen, Man; Moin, Syed M; Kumar, Azad; McLellan, Jason S; Kwong, Peter D; Graham, Barney S; Schaap-Nutt, Anne; Collins, Peter L; Munir, Shirin

2016-11-01

Human respiratory syncytial virus (RSV) and human parainfluenza virus type 3 (HPIV3) are major pediatric respiratory pathogens that lack vaccines. A chimeric bovine/human PIV3 (rB/HPIV3) virus expressing the unmodified, wild-type (wt) RSV fusion (F) protein from an added gene was previously evaluated in seronegative children as a bivalent intranasal RSV/HPIV3 vaccine, and it was well tolerated but insufficiently immunogenic for RSV F. We recently showed that rB/HPIV3 expressing a partially stabilized prefusion form (pre-F) of RSV F efficiently induced "high-quality" RSV-neutralizing antibodies, defined as antibodies that neutralize RSV in vitro without added complement (B. Liang et al., J Virol 89:9499-9510, 2015, doi:10.1128/JVI.01373-15). In the present study, we modified RSV F by replacing its cytoplasmic tail (CT) domain or its CT and transmembrane (TM) domains (TMCT) with counterparts from BPIV3 F, with or without pre-F stabilization. This resulted in RSV F being packaged in the rB/HPIV3 particle with an efficiency similar to that of RSV particles. Enhanced packaging was substantially attenuating in hamsters (10- to 100-fold) and rhesus monkeys (100- to 1,000-fold). Nonetheless, TMCT-directed packaging substantially increased the titers of high-quality RSV-neutralizing serum antibodies in hamsters. In rhesus monkeys, a strongly additive immunogenic effect of packaging and pre-F stabilization was observed, as demonstrated by 8- and 30-fold increases of RSV-neutralizing serum antibody titers in the presence and absence of added complement, respectively, compared to pre-F stabilization alone. Analysis of vaccine-induced F-specific antibodies by binding assays indicated that packaging conferred substantial stabilization of RSV F in the pre-F conformation. This provides an improved version of this well-tolerated RSV/HPIV3 vaccine candidate, with potently improved immunogenicity, which can be returned to clinical trials. Human respiratory syncytial virus (RSV) and human parainfluenza virus type 3 (HPIV3) are major viral agents of acute pediatric bronchiolitis and pneumonia worldwide that lack vaccines. A bivalent intranasal RSV/HPIV3 vaccine candidate consisting of a chimeric bovine/human PIV3 (rB/HPIV3) strain expressing the RSV fusion (F) protein was previously shown to be well tolerated by seronegative children but was insufficiently immunogenic for RSV F. In the present study, the RSV F protein was engineered to be packaged efficiently into vaccine virus particles. This resulted in a significantly enhanced quantity and quality of RSV-neutralizing antibodies in hamsters and nonhuman primates. In nonhuman primates, this effect was strongly additive to the previously described stabilization of the prefusion conformation of the F protein. The improved immunogenicity of RSV F by packaging appeared to involve prefusion stabilization. These findings provide a potently more immunogenic version of this well-tolerated vaccine candidate and should be applicable to other vectored vaccines. Copyright © 2016, American Society for Microbiology. All Rights Reserved.

Packaging and Prefusion Stabilization Separately and Additively Increase the Quantity and Quality of Respiratory Syncytial Virus (RSV)-Neutralizing Antibodies Induced by an RSV Fusion Protein Expressed by a Parainfluenza Virus Vector

PubMed Central

Liang, Bo; Ngwuta, Joan O.; Herbert, Richard; Swerczek, Joanna; Dorward, David W.; Amaro-Carambot, Emerito; Mackow, Natalie; Kabatova, Barbora; Lingemann, Matthias; Surman, Sonja; Yang, Lijuan; Chen, Man; Moin, Syed M.; Kumar, Azad; McLellan, Jason S.; Kwong, Peter D.; Graham, Barney S.; Schaap-Nutt, Anne; Collins, Peter L.

2016-01-01

ABSTRACT Human respiratory syncytial virus (RSV) and human parainfluenza virus type 3 (HPIV3) are major pediatric respiratory pathogens that lack vaccines. A chimeric bovine/human PIV3 (rB/HPIV3) virus expressing the unmodified, wild-type (wt) RSV fusion (F) protein from an added gene was previously evaluated in seronegative children as a bivalent intranasal RSV/HPIV3 vaccine, and it was well tolerated but insufficiently immunogenic for RSV F. We recently showed that rB/HPIV3 expressing a partially stabilized prefusion form (pre-F) of RSV F efficiently induced “high-quality” RSV-neutralizing antibodies, defined as antibodies that neutralize RSV in vitro without added complement (B. Liang et al., J Virol 89:9499–9510, 2015, doi:10.1128/JVI.01373-15). In the present study, we modified RSV F by replacing its cytoplasmic tail (CT) domain or its CT and transmembrane (TM) domains (TMCT) with counterparts from BPIV3 F, with or without pre-F stabilization. This resulted in RSV F being packaged in the rB/HPIV3 particle with an efficiency similar to that of RSV particles. Enhanced packaging was substantially attenuating in hamsters (10- to 100-fold) and rhesus monkeys (100- to 1,000-fold). Nonetheless, TMCT-directed packaging substantially increased the titers of high-quality RSV-neutralizing serum antibodies in hamsters. In rhesus monkeys, a strongly additive immunogenic effect of packaging and pre-F stabilization was observed, as demonstrated by 8- and 30-fold increases of RSV-neutralizing serum antibody titers in the presence and absence of added complement, respectively, compared to pre-F stabilization alone. Analysis of vaccine-induced F-specific antibodies by binding assays indicated that packaging conferred substantial stabilization of RSV F in the pre-F conformation. This provides an improved version of this well-tolerated RSV/HPIV3 vaccine candidate, with potently improved immunogenicity, which can be returned to clinical trials. IMPORTANCE Human respiratory syncytial virus (RSV) and human parainfluenza virus type 3 (HPIV3) are major viral agents of acute pediatric bronchiolitis and pneumonia worldwide that lack vaccines. A bivalent intranasal RSV/HPIV3 vaccine candidate consisting of a chimeric bovine/human PIV3 (rB/HPIV3) strain expressing the RSV fusion (F) protein was previously shown to be well tolerated by seronegative children but was insufficiently immunogenic for RSV F. In the present study, the RSV F protein was engineered to be packaged efficiently into vaccine virus particles. This resulted in a significantly enhanced quantity and quality of RSV-neutralizing antibodies in hamsters and nonhuman primates. In nonhuman primates, this effect was strongly additive to the previously described stabilization of the prefusion conformation of the F protein. The improved immunogenicity of RSV F by packaging appeared to involve prefusion stabilization. These findings provide a potently more immunogenic version of this well-tolerated vaccine candidate and should be applicable to other vectored vaccines. PMID:27581977

Neutron Electric Dipole Moment from Gauge-String Duality.

PubMed

Bartolini, Lorenzo; Bigazzi, Francesco; Bolognesi, Stefano; Cotrone, Aldo L; Manenti, Andrea

2017-03-03

We compute the electric dipole moment of nucleons in the large N_{c} QCD model by Witten, Sakai, and Sugimoto with N_{f}=2 degenerate massive flavors. Baryons in the model are instantonic solitons of an effective five-dimensional action describing the whole tower of mesonic fields. We find that the dipole electromagnetic form factor of the nucleons, induced by a finite topological θ angle, exhibits complete vector meson dominance. We are able to evaluate the contribution of each vector meson to the final result-a small number of modes are relevant to obtain an accurate estimate. Extrapolating the model parameters to real QCD data, the neutron electric dipole moment is evaluated to be d_{n}=1.8×10^{-16}θ e cm. The electric dipole moment of the proton is exactly the opposite.

Correction of Murine Sickle Cell Disease Using γ-Globin Lentiviral Vectors to Mediate High-level Expression of Fetal Hemoglobin

PubMed Central

Pestina, Tamara I; Hargrove, Phillip W; Jay, Dennis; Gray, John T; Boyd, Kelli M; Persons, Derek A

2008-01-01

Increased levels of red cell fetal hemogloblin, whether due to hereditary persistence of expression or from induction with hydroxyurea therapy, effectively ameliorate sickle cell disease (SCD). Therefore, we developed erythroid-specific, γ-globin lentiviral vectors for hematopoietic stem cell (HSC)-targeted gene therapy with the goal of permanently increasing fetal hemoglobin (HbF) production in sickle red cells. We evaluated two different γ-globin lentiviral vectors for therapeutic efficacy in the BERK sickle cell mouse model. The first vector, V5, contained the γ-globin gene driven by 3.1 kb of β-globin regulatory sequences and a 130-bp β-globin promoter. The second vector, V5m3, was identical except that the γ-globin 3′-untranslated region (3′-UTR) was replaced with the β-globin 3′-UTR. Adult erythroid cells have β-globin mRNA 3′-UTR-binding proteins that enhance β-globin mRNA stability and we postulated this design might enhance γ-globin expression. Stem cell gene transfer was efficient and nearly all red cells in transplanted mice expressed human γ-globin. Both vectors demonstrated efficacy in disease correction, with the V5m3 vector producing a higher level of γ-globin mRNA which was associated with high-level correction of anemia and secondary organ pathology. These data support the rationale for a gene therapy approach to SCD by permanently enhancing HbF using a γ-globin lentiviral vector. PMID:19050697

Further development of raccoon poxvirus-vectored vaccines against plague (Yersinia pestis)

USGS Publications Warehouse

Rocke, Tonie E.; Iams, Keith P.; Dawe, S.; Smith, Susan; Williamson, Judy L.; Heisey, Dennis M.; Osorio, Jorge E.

2009-01-01

In previous studies, we demonstrated protection against plague in mice and prairie dogs using a raccoon pox (RCN) virus-vectored vaccine that expressed the F1 capsular antigen of Yersinia pestis. In order to improve vaccine efficacy, we have now constructed additional RCN-plague vaccines containing two different forms of the lcrV (V) gene, including full-length (Vfull) and a truncated form (V307). Mouse challenge studies with Y. pestis strain CO92 showed that vaccination with a combination of RCN-F1 and the truncated V construct (RCN-V307) provided the greatest improvement (P = 0.01) in protection against plague over vaccination with RCN-F1 alone. This effect was mediated primarily by anti-F1 and anti-V antibodies and both contributed independently to increased survival of vaccinated mice.

Further development of raccoon poxvirus-vectored vaccines against plague (Yersinia pestis).

PubMed

Rocke, Tonie E; Iams, Keith P; Dawe, Sandra; Smith, Susan R; Williamson, Judy L; Heisey, Dennis M; Osorio, Jorge E

2009-12-11

In previous studies, we demonstrated protection against plague in mice and prairie dogs using a raccoon pox (RCN) virus-vectored vaccine that expressed the F1 capsular antigen of Yersinia pestis. In order to improve vaccine efficacy, we have now constructed additional RCN-plague vaccines containing two different forms of the lcrV (V) gene, including full-length (Vfull) and a truncated form (V307). Mouse challenge studies with Y. pestis strain CO92 showed that vaccination with a combination of RCN-F1 and the truncated V construct (RCN-V307) provided the greatest improvement (P=0.01) in protection against plague over vaccination with RCN-F1 alone. This effect was mediated primarily by anti-F1 and anti-V antibodies and both contributed independently to increased survival of vaccinated mice.

Interacting cytoplasmic loops of subunits a and c of Escherichia coli F1F0 ATP synthase gate H+ transport to the cytoplasm.

PubMed

Steed, P Ryan; Kraft, Kaitlin A; Fillingame, Robert H

2014-11-25

H(+)-transporting F1F0 ATP synthase catalyzes the synthesis of ATP via coupled rotary motors within F0 and F1. H(+) transport at the subunit a-c interface in transmembranous F0 drives rotation of a cylindrical c10 oligomer within the membrane, which is coupled to rotation of subunit γ within the α3β3 sector of F1 to mechanically drive ATP synthesis. F1F0 functions in a reversible manner, with ATP hydrolysis driving H(+) transport. ATP-driven H(+) transport in a select group of cysteine mutants in subunits a and c is inhibited after chelation of Ag(+) and/or Cd(+2) with the substituted sulfhydryl groups. The H(+) transport pathway mapped via these Ag(+)(Cd(+2))-sensitive Cys extends from the transmembrane helices (TMHs) of subunits a and c into cytoplasmic loops connecting the TMHs, suggesting these loop regions could be involved in gating H(+) release to the cytoplasm. Here, using select loop-region Cys from the single cytoplasmic loop of subunit c and multiple cytoplasmic loops of subunit a, we show that Cd(+2) directly inhibits passive H(+) transport mediated by F0 reconstituted in liposomes. Further, in extensions of previous studies, we show that the regions mediating passive H(+) transport can be cross-linked to each other. We conclude that the loop-regions in subunits a and c that are implicated in H(+) transport likely interact in a single structural domain, which then functions in gating H(+) release to the cytoplasm.

Vector magnetometry of Fe/Cr/Fe trilayers with biquadratic coupling

NASA Astrophysics Data System (ADS)

Mansell, R.; Petit, D.; Fernández-Pacheco, A.; Lee, J. H.; Chin, S.-L.; Lavrijsen, R.; Cowburn, R. P.

2017-05-01

The magnetic reversal of epitaxial Fe/Cr/Fe trilayer samples grown on GaAs is studied. In wedged samples both long and short period coupling oscillations associated with Ruderman-Kittel-Kasuya-Yosida (RKKY) coupling in Cr are seen in the easy axis saturation fields. By using vector vibrating sample magnetometry and both longitudinal and transverse magneto-optical Kerr effect magnetometry we are able to determine the exact reversal path of both the magnetic layers. Changes in the reversal behavior are seen with sub-monolayer changes of the thickness of the Cr interlayer. The two main reversal paths are described in terms of whether the reversal is dominated by bilinear RKKY coupling, which leads to an antiparallel state at remanence or by biquadratic coupling which leads to a 90 degree alignment of layers at remanence. The changing reversal behaviour is discussed with respect to the possibility of using such systems for multilayer memory applications and, in particular, the limits on the required accuracy of the sample growth.

Covariantized vector Galileons

NASA Astrophysics Data System (ADS)

Hull, Matthew; Koyama, Kazuya; Tasinato, Gianmassimo

2016-03-01

Vector Galileons are ghost-free systems containing higher derivative interactions of vector fields. They break the vector gauge symmetry, and the dynamics of the longitudinal vector polarizations acquire a Galileon symmetry in an appropriate decoupling limit in Minkowski space. Using an Arnowitt-Deser-Misner approach, we carefully reconsider the coupling with gravity of vector Galileons, with the aim of studying the necessary conditions to avoid the propagation of ghosts. We develop arguments that put on a more solid footing the results previously obtained in the literature. Moreover, working in analogy with the scalar counterpart, we find indications for the existence of a "beyond Horndeski" theory involving vector degrees of freedom that avoids the propagation of ghosts thanks to secondary constraints. In addition, we analyze a Higgs mechanism for generating vector Galileons through spontaneous symmetry breaking, and we present its consistent covariantization.

Plate Wave Resonance with Air-Coupled Ultrasonics

NASA Astrophysics Data System (ADS)

Bar, H. N.; Dayal, V.; Barnard, D.; Hsu, D. K.

2010-02-01

Air-coupled ultrasonic transducers can excite plate waves in metals and composites. The coincidence effect, i.e., the wave vector of plate wave coincides with projection of exciting airborne sound vector, leads to a resonance which strongly amplifies the sound transmission through the plate. The resonance depends on the angle of incidence and the frequency. In the present study, the incidence angle for maximum transmission (θmax) is measured in plates of steel, aluminum, carbon fiber reinforced composites and honeycomb sandwich panels. The variations of (θmax) with plate thickness are compared with theoretical values in steel, aluminum and quasi-isotropic carbon fiber composites. The enhanced transmission of air-coupled ultrasound at oblique incidence can substantially improve the probability of flaw detection in plates and especially in honeycomb structures. Experimental air-coupled ultrasonic scan of subtle flaws in CFRP laminates showed definite improvement of signal-to-noise ratio with oblique incidence at θmax.

Topological Triply Degenerate Points Induced by Spin-Tensor-Momentum Couplings

NASA Astrophysics Data System (ADS)

Hu, Haiping; Hou, Junpeng; Zhang, Fan; Zhang, Chuanwei

2018-06-01

The recent discovery of triply degenerate points (TDPs) in topological materials has opened a new perspective toward the realization of novel quasiparticles without counterparts in quantum field theory. The emergence of such protected nodes is often attributed to spin-vector-momentum couplings. We show that the interplay between spin-tensor- and spin-vector-momentum couplings can induce three types of TDPs, classified by different monopole charges (C =±2 , ±1 , 0). A Zeeman field can lift them into Weyl points with distinct numbers and charges. Different TDPs of the same type are connected by intriguing Fermi arcs at surfaces, and transitions between different types are accompanied by level crossings along high-symmetry lines. We further propose an experimental scheme to realize such TDPs in cold-atom optical lattices. Our results provide a framework for studying spin-tensor-momentum coupling-induced TDPs and other exotic quasiparticles.

Coupling of the hydration water dynamics and the internal dynamics of actin detected by quasielastic neutron scattering

DOE Office of Scientific and Technical Information (OSTI.GOV)

Fujiwara, Satoru, E-mail: fujiwara.satoru@jaea.go.jp; Plazanet, Marie; Oda, Toshiro

2013-02-15

Highlights: ► Quasielastic neutron scattering spectra of F-actin and G-actin were measured. ► Analysis of the samples in D{sub 2}O and H{sub 2}O provided the spectra of hydration water. ► The first layer hydration water around F-actin is less mobile than around G-actin. ► This difference in hydration water is in concert with the internal dynamics of actin. ► Water outside the first layer behaves bulk-like but influenced by the first layer. -- Abstract: In order to characterize dynamics of water molecules around F-actin and G-actin, quasielastic neutron scattering experiments were performed on powder samples of F-actin and G-actin, hydratedmore » either with D{sub 2}O or H{sub 2}O, at hydration ratios of 0.4 and 1.0. By combined analysis of the quasielastic neutron scattering spectra, the parameter values characterizing the dynamics of the water molecules in the first hydration layer and those of the water molecules outside of the first layer were obtained. The translational diffusion coefficients (D{sub T}) of the hydration water in the first layer were found to be 1.2 × 10{sup −5} cm{sup 2}/s and 1.7 × 10{sup −5} cm{sup 2}/s for F-actin and G-actin, respectively, while that for bulk water was 2.8 × 10{sup −5} cm{sup 2}/s. The residence times were 6.6 ps and 5.0 ps for F-actin and G-actin, respectively, while that for bulk water was 0.62 ps. These differences between F-actin and G-actin, indicating that the hydration water around G-actin is more mobile than that around F-actin, are in concert with the results of the internal dynamics of F-actin and G-actin, showing that G-actin fluctuates more rapidly than F-actin. This implies that the dynamics of the hydration water is coupled to the internal dynamics of the actin molecules. The D{sub T} values of the water molecules outside of the first hydration layer were found to be similar to that of bulk water though the residence times are strongly affected by the first hydration layer. This supports the recent observation on intracellular water that shows bulk-like behavior.« less

Text analysis devices, articles of manufacture, and text analysis methods

DOEpatents

Turner, Alan E; Hetzler, Elizabeth G; Nakamura, Grant C

2015-03-31

Text analysis devices, articles of manufacture, and text analysis methods are described according to some aspects. In one aspect, a text analysis device includes a display configured to depict visible images, and processing circuitry coupled with the display and wherein the processing circuitry is configured to access a first vector of a text item and which comprises a plurality of components, to access a second vector of the text item and which comprises a plurality of components, to weight the components of the first vector providing a plurality of weighted values, to weight the components of the second vector providing a plurality of weighted values, and to combine the weighted values of the first vector with the weighted values of the second vector to provide a third vector.

Investigating Soil Moisture Feedbacks on Precipitation With Tests of Granger Causality

NASA Astrophysics Data System (ADS)

Salvucci, G. D.; Saleem, J. A.; Kaufmann, R.

2002-05-01

Granger causality (GC) is used in the econometrics literature to identify the presence of one- and two-way coupling between terms in noisy multivariate dynamical systems. Here we test for the presence of GC to identify a soil moisture (S) feedback on precipitation (P) using data from Illinois. In this framework S is said to Granger cause P if F(Pt;At-dt)does not equal F(P;(A-S)t-dt) where F denotes the conditional distribution of P at time t, At-dt represents the set of all knowledge available at time t-dt, and (A-S)t-dt represents all knowledge available at t-dt except S. Critical for land-atmosphere interaction research is that At-dt includes all past information on P as well as S. Therefore that part of the relation between past soil moisture and current precipitation which results from precipitation autocorrelation and soil water balance will be accounted for and not attributed to causality. Tests for GC usually specify all relevant variables in a coupled vector autoregressive (VAR) model and then calculate the significance level of decreased predictability as various coupling coefficients are omitted. But because the data (daily precipitation and soil moisture) are distinctly non-Gaussian, we avoid using a VAR and instead express the daily precipitation events as a Markov model. We then test whether the probability of storm occurrence, conditioned on past information on precipitation, changes with information on soil moisture. Past information on precipitation is expressed both as the occurrence of previous day precipitation (to account for storm-scale persistence) and as a simple soil moisture-like precipitation-wetness index derived solely from precipitation (to account for seasonal-scale persistence). In this way only those fluctuations in moisture not attributable to past fluctuations in precipitation (e.g., those due to temperature) can influence the outcome of the test. The null hypothesis (no moisture influence) is evaluated by comparing observed changes in storm probability to Monte-Carlo simulated differences generated with unconditional occurrence probabilities. The null hypothesis is not rejected (p>0.5) suggesting that contrary to recently published results, insufficient evidence exists to support an influence of soil moisture on precipitation in Illinois.

Linear Transformation Method for Multinuclide Decay Calculation

DOE Office of Scientific and Technical Information (OSTI.GOV)

Ding Yuan

2010-12-29

A linear transformation method for generic multinuclide decay calculations is presented together with its properties and implications. The method takes advantage of the linear form of the decay solution N(t) = F(t)N{sub 0}, where N(t) is a column vector that represents the numbers of atoms of the radioactive nuclides in the decay chain, N{sub 0} is the initial value vector of N(t), and F(t) is a lower triangular matrix whose time-dependent elements are independent of the initial values of the system.

The Vector Electric Field Instrument on the C/NOFS Satellite

NASA Technical Reports Server (NTRS)

Pfaff, R.; Kujawski, J.; Uribe, P.; Bromund, K.; Fourre, R.; Acuna, M.; Le, G.; Farrell, W.; Holzworth, R.; McCarthy, M.;

The parity-violating asymmetry in the 3He(n,p)3H reaction

DOE Office of Scientific and Technical Information (OSTI.GOV)

M. Viviani, R. Schiavilla, L. Girlanda, A. Kievsky, L.E. Marcucci

2010-10-01

The longitudinal asymmetry induced by parity-violating (PV) components in the nucleon-nucleon potential is studied in the charge-exchange reaction 3He(n,p)3H at vanishing incident neutron energies. An expression for the PV observable is derived in terms of T-matrix elements for transitions from the {2S+1}L_J=1S_0 and 3S_1 states in the incoming n-3He channel to states with J=0 and 1 in the outgoing p-3H channel. The T-matrix elements involving PV transitions are obtained in first-order perturbation theory in the hadronic weak-interaction potential, while those connecting states of the same parity are derived from solutions of the strong-interaction Hamiltonian with the hyperspherical-harmonics method. The coupled-channelmore » nature of the scattering problem is fully accounted for. Results are obtained corresponding to realistic or chiral two- and three-nucleon strong-interaction potentials in combination with either the DDH or pionless EFT model for the weak-interaction potential. The asymmetries, predicted with PV pion and vector-meson coupling constants corresponding (essentially) to the DDH "best values" set, range from -9.44 to -2.48 in units of 10^{-8}, depending on the input strong-interaction Hamiltonian. This large model dependence is a consequence of cancellations between long-range (pion) and short-range (vector-meson) contributions, and is of course sensitive to the assumed values for the PV coupling constants.« less

Genetic stability of RSV-F expression and the restricted growth phenotype of a live attenuated PIV3 vectored RSV vaccine candidate (MEDI-534) following restrictive growth in human lung cells.

PubMed

Nelson, Christine L; Tang, Roderick S; Stillman, Elizabeth A

2013-08-12

MEDI-534 is the first live, attenuated and vectored respiratory syncytial virus (RSV) vaccine to be evaluated in seronegative children. It consists of a bovine/human parainfluenza virus type 3 (PIV3) backbone with the RSV fusion glycoprotein (RSV-F) expressed from the second position. The PIV3 fusion and hemaglutinin-neuraminidase proteins are human-derived. No small animal appropriately replicates the restrictive growth of bovine PIV3 (bPIV3) based viruses relative to human PIV3 (hPIV3) observed in the respiratory tract of rhesus monkeys and humans, making analysis of the genetic stability of the attenuation phenotype and maintenance of RSV-F expression difficult. Screening of multiple cell-lines identified MRC-5 cells as supporting permissive growth of hPIV3 while restricting bPIV3 and MEDI-534 growth. In MRC-5 cells, the peak titers of MEDI-534 were more than 20-fold lower compared to hPIV3 peak titers. After more than 10 multicycle passages in MRC-5 cells, genetic alterations were detected in MEDI-534 that contributed to a partial loss in restricted growth in MRC-5 cells and a decrease in RSV-F expression. These adaptive mutations did not occur in the RSV-F gene but were found in the polyA sequence upstream of the transgene. MRC-5 adapted MEDI-534 viruses (1) lost some attenuation but did not replicate to the level of hPIV3 in this cell line, (2) did not completely lose RSV-F expression and (3) were able to elicit a protective anti-RSV immune response in hamsters despite lower levels of RSV-F expression. Interestingly analysis of shed MEDI-534 from a recent clinical trial indicates that in some recipients similar mutations arise by day 7 or day 12 post immunization (in press) suggesting that these mutations can arise rapidly in the human host. The utility and limits of MRC-5 cells for characterizing the attenuation and RSV-F expression of MEDI-534 is discussed. Copyright © 2013 The Authors. Published by Elsevier Ltd.. All rights reserved.

Transmission of cutaneous leishmaniasis by sand flies is enhanced by regurgitation of fPPG.

PubMed

Rogers, Matthew E; Ilg, Thomas; Nikolaev, Andrei V; Ferguson, Michael A J; Bates, Paul A

2004-07-22

Sand flies are the exclusive vectors of the protozoan parasite Leishmania, but the mechanism of transmission by fly bite has not been determined nor incorporated into experimental models of infection. In sand flies with mature Leishmania infections the anterior midgut is blocked by a gel of parasite origin, the promastigote secretory gel. Here we analyse the inocula from Leishmania mexicana-infected Lutzomyia longipalpis sand flies. Analysis revealed the size of the infectious dose, the underlying mechanism of parasite delivery by regurgitation, and the novel contribution made to infection by filamentous proteophosphoglycan (fPPG), a component of promastigote secretory gel found to accompany the parasites during transmission. Collectively these results have important implications for understanding the relationship between the parasite and its vector, the pathology of cutaneous leishmaniasis in humans and also the development of effective vaccines and drugs. These findings emphasize that to fully understand transmission of vector-borne diseases the interaction between the parasite, its vector and the mammalian host must be considered together.

Population dynamics of Aedes aegypti from a dengue hyperendemic urban setting in Colombia.

PubMed

Ocampo, Clara B; Wesson, Dawn M

2004-10-01

This study evaluated if the Aedes aegypti population in the city of Cali, Colombia was composed of genetically distinct local populations with different levels of insecticide resistance and dengue vector competence. Insecticide resistance was assayed biochemically and was associated with varying levels of mixed-function oxidases and non-specific esterases. The genes encoding those enzymes were under selective pressure from insecticides used to suppress Ae. aegypti populations. Vector competence showed heterogeneity among the vector populations ranging from 19% to 60%. Population genetic analysis of random amplified polymorphic DNA-polymerase chain reaction products, expressed as genetic distance, Wright's F(st), and migration rate (Nm), demonstrated moderate genetic differentiation among Ae. aegypti from four sites (F(st) = 0.085). The results from all characteristics evaluated in the study demonstrated spatial and temporal variation between Ae. aegypti populations. At any specific time, the local populations of Ae. aegypti were genetically differentiated and unique with respect to insecticide resistance and vector competence. Both characteristics changed independently.

Sensory interactions between six common aroma vectors explain four main red wine aroma nuances.

PubMed

Ferreira, Vicente; Sáenz-Navajas, María-Pilar; Campo, Eva; Herrero, Paula; de la Fuente, Arancha; Fernández-Zurbano, Purificación

2016-05-15

This work aims at assessing the aromatic sensory dimensions linked to 6 common wine aroma vectors (N, norisoprenoids; A, branched acids; F, enolones; E, branched ethyl esters; L, fusel alcohols, M, wood compounds) varying in their natural range of occurrence. Wine models were built by adding the vectors at two levels (fractional factorial design 2(VI)) to a de-aromatised aged red wine. Twenty other different models were evaluated by descriptive analysis. Red, black and dried fruits and woody notes were satisfactorily reproduced. Individual vectors explained just 15% of the sensory space, mostly dependent on perceptual interactions. N influences dried and black fruits and suppresses red fruits. A suppresses black fruits and enhances red and dried fruits. F exerts a major role on red fruits. E suppresses dried fruits and modulates black fruits. L is revealed as a strong suppressor of red fruits and particularly of woody notes. Copyright © 2015 Elsevier Ltd. All rights reserved.

Electron transport properties in fluorinated copper-phthalocyanine films: importance of vibrational reorganization energy and molecular microstructure.

PubMed

Wu, Fu-Chiao; Cheng, Horng-Long; Yen, Chen-Hsiang; Lin, Jyu-Wun; Liu, Shyh-Jiun; Chou, Wei-Yang; Tang, Fu-Ching

2010-03-07

Electron transport (ET) properties of a series of fluorinated copper-phthalocyanine (F(16)CuPc) thin films, which were deposited at different substrate temperatures (T(sub)) ranging from 30 to 150 degrees C, have been investigated by quantum mechanical calculations of the reorganization energy (lambda(reorg)), X-ray diffraction (XRD), atomic force microscopy (AFM), and microRaman spectroscopy. Density functional theory calculations were used to predict the vibrational frequencies, normal mode displacement vectors, and electron-vibrational lambda(reorg) for the F(16)CuPc molecule. The electron mobilities (mu(e)) of F(16)CuPc thin films are strongly dependent on the T(sub), and the value of mu(e) increases with increasing T(sub) from 30 to 120 degrees C, at which point it reaches its maximum value. The importance of electron-vibrational coupling and molecular microstructures for ET properties in F(16)CuPc thin films are discussed on the basis of theoretical vibrational lambda(reorg) calculations and experimental observations of resonance Raman spectra. We observed a good correlation between mu(e) and the full-width-at-half-maximum of the vibrational bands, which greatly contributed to lambda(reorg) and/or which reflects the molecular microstructural quality of the active channel. In contrast, the crystal size analysis by XRD and surface grain morphology by AFM did not reveal a clear correlation with the ET behaviours for these different F(16)CuPc thin films. Therefore, we suggest that for organic films with weak intermolecular interactions, such as F(16)CuPc, optimized microscopic molecular-scale parameters are highly important for efficient long-range charge transport in the macroscopic devices.

Strong coupling constant from Adler function in lattice QCD

NASA Astrophysics Data System (ADS)

Hudspith, Renwick J.; Lewis, Randy; Maltman, Kim; Shintani, Eigo

2016-09-01

We compute the QCD coupling constant, αs, from the Adler function with vector hadronic vacuum polarization (HVP) function. On the lattice, Adler function can be measured by the differential of HVP at two different momentum scales. HVP is measured from the conserved-local vector current correlator using nf = 2 + 1 flavor Domain Wall lattice data with three different lattice cutoffs, up to a-1 ≈ 3.14 GeV. To avoid the lattice artifact due to O(4) symmetry breaking, we set the cylinder cut on the lattice momentum with reflection projection onto vector current correlator, and it then provides smooth function of momentum scale for extracted HVP. We present a global fit of the lattice data at a justified momentum scale with three lattice cutoffs using continuum perturbation theory at 𝒪(αs4) to obtain the coupling in the continuum limit at arbitrary scale. We take the running to Z boson mass through the appropriate thresholds, and obtain αs(5)(MZ) = 0.1191(24)(37) where the first is statistical error and the second is systematic one.

You can hide but you have to run: direct detection with vector mediators

NASA Astrophysics Data System (ADS)

D'Eramo, Francesco; Kavanagh, Bradley J.; Panci, Paolo

2016-08-01

We study direct detection in simplified models of Dark Matter (DM) in which interactions with Standard Model (SM) fermions are mediated by a heavy vector boson. We consider fully general, gauge-invariant couplings between the SM, the mediator and both scalar and fermion DM. We account for the evolution of the couplings between the energy scale of the mediator mass and the nuclear energy scale. This running arises from virtual effects of SM particles and its inclusion is not optional. We compare bounds on the mediator mass from direct detection experiments with and without accounting for the running. In some cases the inclusion of these effects changes the bounds by several orders of magnitude, as a consequence of operator mixing which generates new interactions at low energy. We also highlight the importance of these effects when translating LHC limits on the mediator mass into bounds on the direct detection cross section. For an axial-vector mediator, the running can alter the derived bounds on the spin-dependent DM-nucleon cross section by a factor of two or more. Finally, we provide tools to facilitate the inclusion of these effects in future studies: general approximate expressions for the low energy couplings and a public code runDM to evolve the couplings between arbitrary energy scales.

Supermodes in Coupled Multi-Core Waveguide Structures

DTIC Science & Technology

2016-04-01

and therefore can be treated as linear polarization (LP) modes. In essence, the LP modes are scalar approximations of the vector mode fields and contain...field, including the discovery of optical discrete solitons , Bragg and vector solitons in fibers, nonlinear surface waves, and the discovery of self...increased for an isolated core, it can guide high-order modes. For optical fibers with low re- fractive index contrast, the vector modes are weakly guided

Millimeter Wave Generation by Relativistic Electron Beams.

DTIC Science & Technology

1984-12-01

frequency and wave vector matching relations for influence of various nonlinear effects on this instability is this four-wave interaction require...following coupled mode equations _ 6 = 6 _ (14)-- v vx (14) ." .’ for the lower hybrid sidebands: v - V 2 - The x component of the resultant vector equation...involves a purely growing modte, a four-wave interaction plitoces is analysed, including a u ap ti wave- vector up-shifted and ilown-shiftes upper

Pseudoscalar perturbations and polarization of the cosmic microwave background.

PubMed

Pospelov, Maxim; Ritz, Adam; Skordis, Constantinos

2009-07-31

We show that models of new particle physics containing massless pseudoscalar fields superweakly coupled to photons can be very efficiently probed with CMB polarization anisotropies. The stochastic pseudoscalar fluctuations generated during inflation provide a mechanism for converting E-mode polarization to B-mode during photon propagation from the surface of last scattering. The efficiency of this conversion process is controlled by the dimensionless ratio H/(2pif(a)), where H is the Hubble scale during inflation, and f(a)-1 is the strength of the pseudoscalar coupling to photons. The current observational limits on the B mode constrain this ratio to be less than 0.07, which in many models of inflation translates to a sensitivity to f(a) exceeding 10(14) GeV, which surpasses other tests.

Excitonic Phase Diagram of the Three-Chain Hubbard Model for Semiconducting and Semimetallic Ta2NiSe5

NASA Astrophysics Data System (ADS)

Domon, Kaoru; Yamada, Takemi; Ōno, Yoshiaki

2018-05-01

Transition metal chalcogenide Ta2NiSe5, a promising material for the excitonic insulator, is investigated on the basis of the three-chain Hubbard model with two conduction (c) bands and one valence (f) band. In the semimetallic case where only one of two c bands and the f band cross the Fermi level, the transition from the c-f compensated semimetal to the uniform excitonic order, the so-called excitonic insulator, takes place at low temperature as the same as in the semiconducting case. On the other hand, when another c band also crosses the Fermi level, the system shows three types of Fulde-Ferrell-Larkin-Ovchinnikov (FFLO) excitonic orders characterized by the condensation of excitons with finite center-of-mass momentum q corresponding to the three types of nesting vectors between the imbalanced two c and one f Fermi surfaces. The obtained FFLO excitonic states are metallic in contrast to the excitonic insulator and are expected to be observed in the semimetallic Ta2NiSe5 under high pressure. The effect of the electron-lattice coupling is also discussed briefly and is found to induce the monoclinic distortion not only in the uniform excitonic state but also in the FFLO one resulting in the orthorhombic-monoclinic structural phase transition for both cases as observed in Ta2NiSe5 for both low-pressure semiconducting and high-pressure semimetallic regimes.

Ultralow-energy and high-contrast all-optical switch involving Fano resonance based on coupled photonic crystal nanocavities.

PubMed

Nozaki, Kengo; Shinya, Akihiko; Matsuo, Shinji; Sato, Tomonari; Kuramochi, Eiichi; Notomi, Masaya

2013-05-20

We experimentally and theoretically clarified that a Fano resonant system based on a coupled optical cavity has better performance when used as an all-optical switch than a single cavity in terms of switching energy, contrast, and operation bandwidth. We successfully fabricated a Fano system consisting of doubly coupled photonic-crystal (PhC) nanocavities, and demonstrated all-optical switching for the first time. A steep asymmetric transmission spectrum was clearly observed, thereby enabling a low-energy and high-contrast switching operation. We achieved the switching with a pump energy of a few fJ, a contrast of more than 10 dB, and an 18 ps switching time window. These levels of performance are actually better than those for Lorentzian resonance in a single cavity. We also theoretically investigated the achievable performance in a well-designed Fano system, which suggested a high contrast for the switching of more than 20 dB in a fJ energy regime.

Propulsion Flight Research at NASA Dryden From 1967 to 1997

NASA Technical Reports Server (NTRS)

Burcham, Frank W., Jr.; Ray, Ronald J.; Conners, Timothy R.; Walsh, Kevin R.

1997-01-01

From 1967 to 1997, pioneering propulsion flight research activities have been conceived and conducted at the NASA Dryden Flight Research Center. Many of these programs have been flown jointly with the United States Department of Defense, industry, or the Federal Aviation Administration. Propulsion research has been conducted on the XB-70, F-111 A, F-111E, YF-12, JetStar, B-720, MD-11, F-15, F- 104, Highly Maneuverable Aircraft Technology, F-14, F/A-18, SR-71, and the hypersonic X-15 airplanes. Research studies have included inlet dynamics and control, in-flight thrust computation, integrated propulsion controls, inlet and boattail drag, wind tunnel-to-flight comparisons, digital engine controls, advanced engine control optimization algorithms, acoustics, antimisting kerosene, in-flight lift and drag, throttle response criteria, and thrust-vectoring vanes. A computer-controlled thrust system has been developed to land the F-15 and MD-11 airplanes without using any of the normal flight controls. An F-15 airplane has flown tests of axisymmetric thrust-vectoring nozzles. A linear aerospike rocket experiment has been developed and tested on the SR-71 airplane. This paper discusses some of the more unique flight programs, the results, lessons learned, and their impact on current technology.

New methods for B meson decay constants and form factors from lattice NRQCD

NASA Astrophysics Data System (ADS)

Hughes, C.; Davies, C. T. H.; Monahan, C. J.; Hpqcd Collaboration

2018-03-01

We determine the normalization of scalar and pseudoscalar current operators made from nonrelativistic b quarks and highly improved staggered light quarks in lattice quantum chromodynamics (QCD) through O (αs) and ΛQCD/mb. We use matrix elements of these operators to extract B meson decay constants and form factors, and then compare to those obtained using the standard vector and axial-vector operators. This provides a test of systematic errors in the lattice QCD determination of the B meson decay constants and form factors. We provide a new value for the B and Bs meson decay constants from lattice QCD calculations on ensembles that include u , d , s , and c quarks in the sea and those that have the u /d quark mass going down to its physical value. Our results are fB=0.196 (6 ) GeV , fBs=0.236(7 ) GeV , and fB s/fB=1.207 (7 ), agreeing well with earlier results using the temporal axial current. By combining with these previous results, we provide updated values of fB=0.190 (4 ) GeV , fBs=0.229(5 ) GeV , and fB s/fB=1.206 (5 ).

Survey of Laser-Produced Pressure and Impulse Data

DTIC Science & Technology

1988-01-01

Marseille, Marseille, France; C.E.A. Limeil-Service H.D.E., St. Georges , France Experimental Conditions: Laser: TEA C02 Wavelength: 10.6 pm Pulse energy: to...Mecanique des Fluides de Marseille, Marseille, France; C.E.A. Limeil-Service H.D.E., St. Georges , France Experimental Conditions: Laser: TEA CO2 Wavelength...34 Authors : C.L. Bohn, M.D. Stephen, F. Eng, J.C. Souders, G.A. Brost , T.F. Deaton, B.W. Duvall, and J.T. Tinsley Citation: "Mechanical coupling of an

Polyethyleneimine-lipid conjugate-based pH-sensitive micellar carrier for gene delivery

PubMed Central

Sawant, Rupa R.; Sriraman, Shravan Kumar; Navarro, Gemma; Biswas, Swati; Dalvi, Riddhi A.; Torchilin, Vladimir P.

2012-01-01

A low molecular weight polyethyleneimine (PEI 1.8 kDa) was modified with dioleoylphosphatidylethanolamine (PE) to form the PEI-PE conjugate investigated as a transfection vector. The optimized PEI-PE/pDNA complexes at an N/P ratio of 16 had a particle size of 225 nm, a surface charge of +31 mV, and protected the pDNA from the action of DNase I. The PEI-PE conjugate had a critical micelle concentration (CMC) of about 34 μg/ml and exhibited no toxicity compared to a high molecular weight PEI (PEI 25 kDa) as tested with B16-F10 melanoma cells. The B16-F10 cells transfected with PEI-PE/pEGFP complexes showed protein expression levels higher than with PEI-1.8 or PEI-25 vectors. Complexes prepared with YOYO 1-labeled pEGFP confirmed the enhanced delivery of the plasmid with PEI-PE compared to PEI-1.8 and PEI-25. The PEI-PE/pDNA complexes were also mixed with various amounts of micelle-forming material, polyethylene glycol (PEG)-PE to improve biocompatibility. The resulting particles exhibited a neutral surface charge, resistance to salt-induced aggregation, and good transfection activity in the presence of serum in complete media. The use of the low-pH-degradable PEG-hydrazone-PE produced particles with transfection activity sensitive to changes in pH consistent with the relatively acidic tumor environment. PMID:22365809

Phase separation in solution of worm-like micelles: a dilute ? spin-vector model

NASA Astrophysics Data System (ADS)

Panizza, Pascal; Cristobal, Galder; Curély, Jacques

1998-12-01

We show how the dilute 0953-8984/10/50/006/img2 spin vector model introduced originally by Wheeler and co-workers for describing the polymerization phenomenon in solutions of liquid sulphur and of living polymers may be conveniently adapted for studying phase separation in systems containing long flexible micelles. We draw an isomorphism between the coupling constant appearing in the exchange Hamiltonian and the surfactant energies in the micellar problem. We solve this problem within the mean-field approximation and compare the main results we have obtained with respect to polymer theory and previous theories of phase separation in micellar solutions. We show that the attractive interaction term 0953-8984/10/50/006/img3 between monomers renormalizes the aggregation energy and subsequently the corresponding size distribution. Under these conditions, we observe that the general aspect of the phase diagram in the 0953-8984/10/50/006/img4 plane (where 0953-8984/10/50/006/img5 is the surfactant concentration) is different from previous results. The spinodal line shows a re-entrant behaviour and, at low concentrations, we point out the possibility of specific nucleation phenomena related to the existence of a metastable transition line between a region composed of spherical micelles and another one corresponding to a dilute solution of long flexible micelles.

Sand fly control in Kenya with residual pesticide application on HESCO barriers

USDA-ARS?s Scientific Manuscript database

US military operations in hot-arid regions still face significant impacts from mosquito and sand fly vectors of diseases. Personal protective measures (PPM) such as DEET or treated bed nets and clothing can reduce contact with disease vectors and nuisance insects; however, irregular use of PPM coupl...

ZnO:Zn/6LiF scintillator-A low afterglow alternative to ZnS:Ag/6LiF for thermal neutron detection

NASA Astrophysics Data System (ADS)

Sykora, G. Jeff; Schooneveld, Erik M.; Rhodes, Nigel J.

2018-03-01

Current ZnS:Ag/6LiF based scintillation detectors are often count rate limited by the long lifetime afterglow in the scintillator. Despite this drawback, new instruments at neutron scattering facilities, like ISIS in the UK, would still like to use ZnS:Ag/6LiF detectors due to their low gamma sensitivity, high light output, simplicity of detector design and relatively inexpensive production. One particular advantage of ZnS:Ag/6LiF detectors is their ability to provide strong pulse shape discrimination between neutrons and gammas. Despite the advantages of these detectors, it is becoming clear that new and upgraded instruments will be limited by the count rate capability of ZnS:Ag/6LiF, so an alternative scintillator technology with equivalent simplicity is being sought. ZnO:Zn/6LiF is investigated here as a low afterglow alternative to ZnS:Ag/6LiF. Basic scintillation properties of ZnO:Zn are studied and are discussed. Pulse shape discrimination between neutrons and gammas is explored and taken advantage of through simple single photon counting methods. A further step toward a realistic detector for neutron scattering is also taken by fiber coupling the ZnO:Zn/6LiF to a PMT. In an initial study of this fiber coupled configuration, 60Co gamma sensitivity of ∼ 7 × 10-6 is shown and improvements in count rate capability of at least a factor of 6 over ZnS:Ag/6LiF based neutron detectors are demonstrated.

Vibrio elicits targeted transcriptional responses from copepod hosts.

PubMed

Almada, Amalia A; Tarrant, Ann M

2016-06-01

Copepods are abundant crustaceans that harbor diverse bacterial communities, yet the nature of their interactions with microbiota are poorly understood. Here, we report that Vibrio elicits targeted transcriptional responses in the estuarine copepod Eurytemora affinis We pre-treated E. affinis with an antibiotic cocktail and exposed them to either a zooplankton specialist (Vibrio sp. F10 9ZB36) or a free-living species (Vibrio ordalii 12B09) for 24 h. We then identified via RNA-Seq a total of 78 genes that were differentially expressed following Vibrio exposure, including homologs of C-type lectins, chitin-binding proteins and saposins. The response differed between the two Vibrio treatments, with the greatest changes elicited upon inoculation with V. sp. F10 We suggest that these differentially regulated genes play important roles in cuticle integrity, the innate immune response, and general stress response, and that their expression may enable E. affinis to recognize and regulate symbiotic vibrios. We further report that V. sp. F10 culturability is specifically altered upon colonization of E. affinis These findings suggest that rather than acting as passive environmental vectors, copepods discriminately interact with vibrios, which may ultimately impact the abundance and activity of copepod-associated bacteria. © FEMS 2016. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.

Search for pair production of first and second generation leptoquarks in proton-proton collisions at $$\\sqrt{s} =$$ 8 TeV

DOE PAGES

Khachatryan, Vardan

2016-02-24

Our search for pair production of first and second generation leptoquarks is performed in final states containing either two charged leptons and two jets, or one charged lepton, one neutrino and two jets, using proton-proton collision data at √s = 8 TeV. The data, corresponding to an integrated luminosity of 19.7 fb -1, were recorded with the CMS detector at the LHC. First-generation scalar leptoquarks with masses less than 1010 (850) GeV are excluded for β = 1.0 (0.5), where b is the branching fraction of a leptoquark decaying to a charged lepton and a quark. Similarly, secondgeneration scalar leptoquarksmore » with masses less than 1080 (760) GeV are excluded for β = 1.0 (0.5). Furthermore, mass limits are also set for vector leptoquark production scenarios with anomalous vector couplings, and for R-parity violating supersymmetric scenarios of top squark pair production resulting in similar final-state signatures. These are the most stringent limits placed on the masses of leptoquarks and RPV top squarks to date.« less

Highly Efficient and Scalable Compound Decomposition of Two-Electron Integral Tensor and Its Application in Coupled Cluster Calculations

DOE Office of Scientific and Technical Information (OSTI.GOV)

Peng, Bo; Kowalski, Karol

The representation and storage of two-electron integral tensors are vital in large- scale applications of accurate electronic structure methods. Low-rank representation and efficient storage strategy of integral tensors can significantly reduce the numerical overhead and consequently time-to-solution of these methods. In this paper, by combining pivoted incomplete Cholesky decomposition (CD) with a follow-up truncated singular vector decomposition (SVD), we develop a decomposition strategy to approximately represent the two-electron integral tensor in terms of low-rank vectors. A systematic benchmark test on a series of 1-D, 2-D, and 3-D carbon-hydrogen systems demonstrates high efficiency and scalability of the compound two-step decomposition ofmore » the two-electron integral tensor in our implementation. For the size of atomic basis set N_b ranging from ~ 100 up to ~ 2, 000, the observed numerical scaling of our implementation shows O(N_b^{2.5~3}) versus O(N_b^{3~4}) of single CD in most of other implementations. More importantly, this decomposition strategy can significantly reduce the storage requirement of the atomic-orbital (AO) two-electron integral tensor from O(N_b^4) to O(N_b^2 log_{10}(N_b)) with moderate decomposition thresholds. The accuracy tests have been performed using ground- and excited-state formulations of coupled- cluster formalism employing single and double excitations (CCSD) on several bench- mark systems including the C_{60} molecule described by nearly 1,400 basis functions. The results show that the decomposition thresholds can be generally set to 10^{-4} to 10^{-3} to give acceptable compromise between efficiency and accuracy.« less

Off-shell amplitudes as boundary integrals of analytically continued Wilson line slope

DOE Office of Scientific and Technical Information (OSTI.GOV)

Kotko, P.; Serino, M.; Stasto, A. M.

We consider a conformal complex singlet extension of the Standard Model with a Higgs portal interaction. The global U(1) symmetry of the complex singlet can be either broken or unbroken and we study each scenario. In the unbroken case, the global U(1) symmetry protects the complex singlet from decaying, leading to an ideal cold dark matter candidate with approximately 100 GeV mass along with a significant proportion of thermal relic dark matter abundance. In the broken case, we have developed a renormalization-scale optimization technique to significantly narrow the parameter space and in some situations, provide unique predictions for all themore » model’s couplings and masses. We have found there exists a second Higgs boson with a mass of approximately 550 GeV that mixes with the known 125 GeV Higgs with a large mixing angle sin θ ≈ 0.47 consistent with current experimental limits. The imaginary part of the complex singlet in the broken case could provide axion dark matter for a wide range of models. Upon including interactions of the complex scalar with an additional vector-like fermion, we explore the possibility of a diphoton excess in both the unbroken and the broken cases. In the unbroken case, the model can provide a natural explanation for diphoton excess if extra terms are introduced providing extra contributions to the singlet mass. In the broken case, we find a set of coupling solutions that yield a second Higgs boson of mass 720 GeV and an 830 GeV extra vector-like fermion F , which is able to address the 750 GeV LHC diphoton excess. We also provide criteria to determine the symmetry breaking pattern in both the Higgs and hidden sectors.« less

Conformal complex singlet extension of the Standard Model: scenario for dark matter and a second Higgs boson

NASA Astrophysics Data System (ADS)

Wang, Zhi-Wei; Steele, T. G.; Hanif, T.; Mann, R. B.

2016-08-01

We consider a conformal complex singlet extension of the Standard Model with a Higgs portal interaction. The global U(1) symmetry of the complex singlet can be either broken or unbroken and we study each scenario. In the unbroken case, the global U(1) symmetry protects the complex singlet from decaying, leading to an ideal cold dark matter candidate with approximately 100 GeV mass along with a significant proportion of thermal relic dark matter abundance. In the broken case, we have developed a renormalization-scale optimization technique to significantly narrow the parameter space and in some situations, provide unique predictions for all the model's couplings and masses. We have found there exists a second Higgs boson with a mass of approximately 550 GeV that mixes with the known 125 GeV Higgs with a large mixing angle sin θ ≈ 0.47 consistent with current experimental limits. The imaginary part of the complex singlet in the broken case could provide axion dark matter for a wide range of models. Upon including interactions of the complex scalar with an additional vector-like fermion, we explore the possibility of a diphoton excess in both the unbroken and the broken cases. In the unbroken case, the model can provide a natural explanation for diphoton excess if extra terms are introduced providing extra contributions to the singlet mass. In the broken case, we find a set of coupling solutions that yield a second Higgs boson of mass 720 GeV and an 830 GeV extra vector-like fermion F , which is able to address the 750 GeV LHC diphoton excess. We also provide criteria to determine the symmetry breaking pattern in both the Higgs and hidden sectors.

Eye-hand coupling during closed-loop drawing: evidence of shared motor planning?

PubMed

Reina, G Anthony; Schwartz, Andrew B

2003-04-01

Previous paradigms have used reaching movements to study coupling of eye-hand kinematics. In the present study, we investigated eye-hand kinematics as curved trajectories were drawn at normal speeds. Eye and hand movements were tracked as a monkey traced ellipses and circles with the hand in free space while viewing the hand's position on a computer monitor. The results demonstrate that the movement of the hand was smooth and obeyed the 2/3 power law. Eye position, however, was restricted to 2-3 clusters along the hand's trajectory and fixed approximately 80% of the time in one of these clusters. The eye remained stationary as the hand moved away from the fixation for up to 200 ms and saccaded ahead of the hand position to the next fixation along the trajectory. The movement from one fixation cluster to another consistently occurred just after the tangential hand velocity had reached a local minimum, but before the next segment of the hand's trajectory began. The next fixation point was close to an area of high curvature along the hand's trajectory even though the hand had not reached that point along the path. A visuo-motor illusion of hand movement demonstrated that the eye movement was influenced by hand movement and not simply by visual input. During the task, neural activity of pre-motor cortex (area F4) was recorded using extracellular electrodes and used to construct a population vector of the hand's trajectory. The results suggest that the saccade onset is correlated in time with maximum curvature in the population vector trajectory for the hand movement. We hypothesize that eye and arm movements may have common, or shared, information in forming their motor plans.

Phenomenology of flavorful composite vector bosons in light of B anomalies

NASA Astrophysics Data System (ADS)

Matsuzaki, Shinya; Nishiwaki, Kenji; Watanabe, Ryoutaro

2017-08-01

We analyze the flavor structure of composite vector bosons arising in a model of vectorlike technicolor — often called hypercolor (HC) — with eight flavors that form a one-family content of HC fermions. Dynamics of the composite vector bosons, referred to as HC ρ in this paper, are formulated together with HC pions by the hidden local symmetry (HLS), in a way analogous to QCD vector mesons. Then coupling properties to the standard model (SM) fermions, which respect the HLS gauge symmetry, are described in a way that couplings of the HC ρs to the left-handed SM quarks and leptons are given by a well-defined setup as taking the flavor mixing structures into account. Under the present scenario, we discuss significant bounds on the model from electroweak precision tests, flavor physics, and collider physics. We also try to address B anomalies in processes such as B → K (∗) μ + μ - and B\\to {D}^{(\\ast )}τ\\overline{ν} , recently reported by LHCb, Belle, (ATLAS, and CMS in part). Then we find that the present model can account for the anomaly in B → K (∗) μ + μ - consistently with the other constraints while it predicts no significant deviations in B\\to {D}^{(\\ast )}τ\\overline{ν} ν from the SM, which can be examined in the future Belle II experiment. The former is archived with the form C 9 = - C 10 of the Wilson coefficients for effective operators of b → sμ + μ -, which has been favored by the recent experimental data. We also investigate current and future experimental limits at the Large Hadron Collider (LHC) and see that possible collider signals come from dijet and ditau, or dimuon resonant searches for the present scenario with TeV mass range. To conclude, the present b → sμ + μ - anomaly is likely to imply discovery of new vector bosons in the ditau or dimuon channel in the context of the HC ρ model. Our model can be considered as a UV completion of conventional U(1)' models.

A search for leptoquarks and squarks at HERA

NASA Astrophysics Data System (ADS)

Ahmed, T.; Aid, S.; Andreev, V.; Andrieu, B.; Appuhn, R.-D.; Arpagaus, M.; Babaev, A.; Baehr, J.; Bán, J.; Baranov, P.; Barrelet, E.; Bartel, W.; Barth, M.; Bassler, U.; Beck, H. P.; Behrend, H.-J.; Belousov, A.; Berger, Ch.; Bergstein, H.; Bernardi, G.; Bernet, R.; Bertrand-Coremans, G.; Besançon, M.; Beyer, R.; Biddulph, P.; Bizot, J. C.; Blobel, V.; Borras, K.; Botterweck, F.; Boudry, V.; Braemer, A.; Brasse, F.; Braunschweig, W.; Brisson, V.; Bruncko, D.; Brune, C.; Buchholz, R.; Büngener, L.; Bürger, J.; Büsser, F. W.; Buniatian, A.; Burke, S.; Buschhorn, G.; Campbell, A. J.; Carli, T.; Charles, F.; Clarke, D.; Clegg, A. B.; Colombo, M.; Contreras, J. G.; Coughlan, J. A.; Courau, A.; Coutures, Ch.; Cozzika, G.; Criegee, L.; Cussans, D. G.; Cvach, J.; Dagoret, S.; Dainton, J. B.; Danilov, M.; Dau, W. D.; Daum, K.; David, M.; Deffur, E.; Delcourt, B.; Del Buono, L.; de Roeck, A.; de Wolf, E. A.; di Nezza, P.; Dollfus, C.; Dowell, J. D.; Dreis, H. B.; Duboc, J.; Düllmann, D.; Dünger, O.; Duhm, H.; Ebert, J.; Ebert, T. R.; Eckerlin, G.; Efremenko, V.; Egli, S.; Ehrlichmann, H.; Eichenberger, S.; Eichler, R.; Eisele, F.; Eisenhandler, E.; Ellison, R. J.; Elsen, E.; Erdmann, M.; Erdmann, W.; Evrard, E.; Favart, L.; Fedotov, A.; Feeken, D.; Felst, R.; Feltesse, J.; Ferencei, J.; Ferrarotto, F.; Flamm, K.; Fleischer, M.; Flieser, M.; Flügge, G.; Fomenko, A.; Fominykh, B.; Forbush, M.; Formánek, J.; Foster, J. M.; Franke, G.; Fretwurst, E.; Gabathuler, E.; Gabathuler, K.; Gamerdinger, K.; Garvey, J.; Gayler, J.; Gebauer, M.; Gellrich, A.; Genzel, H.; Gerhards, R.; Goerlach, U.; Goerlich, L.; Gogitidze, N.; Goldberg, M.; Goldner, D.; Gonzalez-Pineiro, B.; Goodall, A. M.; Gorelov, I.; Goritchev, P.; Grab, C.; Grässler, H.; Grässler, R.; Greenshaw, T.; Grindhammer, G.; Gruber, A.; Gruber, C.; Haack, J.; Haidt, D.; Hajduk, L.; Hamon, O.; Hampel, M.; Hanlon, E. M.; Hapke, M.; Haynes, W. J.; Heatherington, J.; Hedberg, V.; Heinzelmann, G.; Henderson, R. C. W.; Henschel, H.; Herma, R.; Herynek, I.; Hess, M. F.; Hildesheim, W.; Hill, P.; Hiller, K. H.; Hilton, C. D.; Hladký, J.; Hoeger, K. C.; Höppner, M.; Horisberger, R.; Huet, Ph.; Hufnagel, H.; Ibbotson, M.; Itterbeck, H.; Jabiol, M.-A.; Jacholkowska, A.; Jacobsson, C.; Jaffre, M.; Janoth, J.; Jansen, T.; Jönsson, L.; Johannsen, K.; Johnson, D. P.; Johnson, L.; Jung, H.; Kalmus, P. I. P.; Kant, D.; Kaschowitz, R.; Kasselmann, P.; Kathage, U.; Kaufmann, H. H.; Kazarian, S.; Kenyon, I. R.; Kermiche, S.; Keuker, C.; Kiesling, C.; Klein, M.; Kleinwort, C.; Knies, G.; Ko, W.; Köhler, T.; Kolanoski, H.; Kole, F.; Kolya, S. D.; Korbel, V.; Korn, M.; Kostka, P.; Kotelnikov, S. K.; Krasny, M. W.; Krehbiel, H.; Krücker, D.; Krüger, U.; Krüner-Marquis, U.; Kubenka, J. P.; Küster, H.; Kuhlen, M.; Kurča, T.; Kurzhöfer, J.; Kuznik, B.; Lacour, D.; Lamarche, F.; Lander, R.; Landon, M. P. J.; Lange, W.; Lanius, P.; Laporte, J.-F.; Lebedev, A.; Leverenz, C.; Levonian, S.; Ley, Ch.; Lindner, A.; Lindström, G.; Linsel, F.; Lipinski, J.; List, B.; Loch, P.; Lohmander, H.; Lopez, G. C.; Lüke, D.; Magnussen, N.; Malinovski, E.; Mani, S.; Maraček, R.; Marage, P.; Marks, J.; Marshall, R.; Martens, J.; Martin, R.; Martyn, H.-U.; Martyniak, J.; Masson, S.; Mavroidis, T.; Maxfield, S. J.; McMahon, S. J.; Mehta, A.; Meier, K.; Mercer, D.; Merz, T.; Meyer, C. A.; Meyer, H.; Meyer, J.; Mikocki, S.; Milstead, D.; Moreau, F.; Morris, J. V.; Müller, G.; Müller, K.; Murín, P.; Nagovizin, V.; Nahnhauer, R.; Naroska, B.; Naumann, Th.; Newman, P. R.; Newton, D.; Neyret, D.; Nguyen, H. K.; Niebergall, F.; Niebuhr, C.; Nisius, R.; Nowak, G.; Noyes, G. W.; Nyberg-Werther, M.; Oberlack, H.; Obrock, U.; Olsson, J. E.; Panaro, E.; Panitch, A.; Pascaud, C.; Patel, G. D.; Peppel, E.; Perez, E.; Phillips, J. P.; Pichler, Ch.; Pitzl, D.; Pope, G.; Prell, S.; Prosi, R.; Rädel, G.; Raupach, F.; Reimer, P.; Reinshagen, S.; Ribarics, P.; Riech, V.; Riedlberger, J.; Riess, S.; Rietz, M.; Robertson, S. M.; Robmann, P.; Roloff, H. E.; Roosen, R.; Rosenbauer, K.; Rostovtsev, A.; Rouse, F.; Royon, C.; Rüter, K.; Rusakov, S.; Rybicki, K.; Rylko, R.; Sahlmann, N.; Sanchez, E.; Sankey, D. P. C.; Savitsky, M.; Schacht, P.; Schiek, S.; Schleper, P.; von Schlippe, W.; Schmidt, C.; Schmidt, D.; Schmidt, G.; Schöning, A.; Schröder, V.; Schuhmann, E.; Schwab, B.; Schwind, A.; Seehausen, U.; Sefkow, F.; Seidel, M.; Sell, R.; Semenov, A.; Shekelyan, V.; Sheviakov, I.; Shooshtari, H.; Shtarkov, L. N.; Siegmon, G.; Siewert, U.; Sirois, Y.; Skillicorn, I. O.; Smirnov, P.; Smith, J. R.; Soloviev, Y.; Spitzer, H.; Starosta, R.; Steenbock, M.; Steffen, P.; Steinberg, R.; Stella, B.; Stephens, K.; Stier, J.; Stiewe, J.; Stösslein, U.; Strachota, J.; Straumann, U.; Struczinski, W.; Sutton, J. P.; Tapprogge, S.; Taylor, R. E.; Tchernyshov, V.; Thiebaux, C.; Thompson, G.; Tichomirov, I.; Truöl, P.; Turnau, J.; Tutas, J.; Uelkes, P.; Usik, A.; Valkár, S.; Valkárová, A.; Vallée, C.; van Esch, P.; van Mechelen, P.; Vartapetian, A.; Vazdik, Y.; Vecko, M.; Verrecchia, P.; Villet, G.; Wacker, K.; Wagener, A.; Wagener, M.; Walker, I. W.; Walther, A.; Weber, G.; Weber, M.; Wegener, D.; Wegner, A.; Wellisch, H. P.; West, L. R.; Willard, S.; Winde, M.; Winter, G.-G.; Wright, A. E.; Wünsch, E.; Wulff, N.; Yiou, T. P.; Žáček, J.; Zarbock, D.; Zhang, Z.; Zimmer, M.; Zimmermann, W.; Zomer, F.; Zuber, K.

1994-12-01

A search in the H1 experiment at HERA for scalar and vector leptoquarks, leptogluons and squarks coupling to first generation fermions is presented in a data sample corresponding to an integrated luminosity of 425 nb-1. For masses ranging up to ˜275 GeV, no significant evidence for the direct production of such particles is found in various possible decay channels. At high masses and beyond the centre of mass energy of 296 GeV a contact interaction analysis is used to further constrain the couplings and masses of new vector leptoquarks and to set lower limits on compositeness scales.

Localization of U(1) gauge vector field on flat branes with five-dimension (asymptotic) AdS5 spacetime

NASA Astrophysics Data System (ADS)

Zhao, Zhen-Hua; Xie, Qun-Ying

2018-05-01

In order to localize U(1) gauge vector field on Randall-Sundrum-like braneworld model with infinite extra dimension, we propose a new kind of non-minimal coupling between the U(1) gauge field and the gravity. We propose three kinds of coupling methods and they all support the localization of zero mode. In addition, one of them can support the localization of massive modes. Moreover, the massive tachyonic modes can be excluded. And our method can be used not only in the thin braneword models but also in the thick ones.

Measurement of vector boson scattering and constraints on anomalous quartic couplings from events with four leptons and two jets in proton–proton collisions at s = 13   TeV

DOE Office of Scientific and Technical Information (OSTI.GOV)

Sirunyan, A. M.; Tumasyan, A.; Adam, W.

A measurement of vector boson scattering and constraints on anomalous quartic gauge couplings from events with two Z bosons and two jets are presented. The analysis is based on a data sample of proton–proton collisions at √s = 13 TeV collected with the CMS detector and corresponding to an integrated luminosity of 35.9fb –1. Here, the search is performed in the fully leptonic final state ZZ → lll'l', where l,l' = e or μ.

Bright, dark, and mixed vector soliton solutions of the general coupled nonlinear Schrödinger equations.

PubMed

Agalarov, Agalar; Zhulego, Vladimir; Gadzhimuradov, Telman

2015-04-01

The reduction procedure for the general coupled nonlinear Schrödinger (GCNLS) equations with four-wave mixing terms is proposed. It is shown that the GCNLS system is equivalent to the well known integrable families of the Manakov and Makhankov U(n,m)-vector models. This equivalence allows us to construct bright-bright and dark-dark solitons and a quasibreather-dark solution with unconventional dynamics: the density of the first component oscillates in space and time, whereas the density of the second component does not. The collision properties of solitons are also studied.

Weak mixing below the weak scale in dark-matter direct detection

NASA Astrophysics Data System (ADS)

Brod, Joachim; Grinstein, Benjamin; Stamou, Emmanuel; Zupan, Jure

2018-02-01

If dark matter couples predominantly to the axial-vector currents with heavy quarks, the leading contribution to dark-matter scattering on nuclei is either due to one-loop weak corrections or due to the heavy-quark axial charges of the nucleons. We calculate the effects of Higgs and weak gauge-boson exchanges for dark matter coupling to heavy-quark axial-vector currents in an effective theory below the weak scale. By explicit computation, we show that the leading-logarithmic QCD corrections are important, and thus resum them to all orders using the renormalization group.

Measurement of vector boson scattering and constraints on anomalous quartic couplings from events with four leptons and two jets in proton–proton collisions at s = 13   TeV

DOE PAGES

Sirunyan, A. M.; Tumasyan, A.; Adam, W.; ...

2017-10-17

A measurement of vector boson scattering and constraints on anomalous quartic gauge couplings from events with two Z bosons and two jets are presented. The analysis is based on a data sample of proton–proton collisions at √s = 13 TeV collected with the CMS detector and corresponding to an integrated luminosity of 35.9fb –1. Here, the search is performed in the fully leptonic final state ZZ → lll'l', where l,l' = e or μ.

Genetic modification of hematopoietic cells using retroviral and lentiviral vectors: safety considerations for vector design and delivery into target cells.

PubMed

Dropulic, Boro

2005-07-01

The recent development of leukemia in three patients following retroviral vector gene transfer in hematopoietic stem cells, resulting in the death of one patient, has raised safety concerns for the use of integrating gene transfer vectors for human gene therapy. This review discusses these serious adverse events from the perspective of whether restrictions on vector design and vector-modified target cells are warranted at this time. A case is made against presently establishing specific restrictions for vector design and transduced cells; rather, their safety should be ascertained by empiric evaluation in appropriate preclinical models on a case-by-case basis. Such preclinical data, coupled with proper informed patient consent and a risk-benefit ratio analysis, provide the best available prospective evaluation of gene transfer vectors prior to their translation into the clinic.

Flight-Determined Subsonic Longitudinal Stability and Control Derivatives of the F-18 High Angle of Attack Research Vehicle (HARV) with Thrust Vectoring

NASA Technical Reports Server (NTRS)

Iliff, Kenneth W.; Wang, Kon-Sheng Charles

1997-01-01

The subsonic longitudinal stability and control derivatives of the F-18 High Angle of Attack Research Vehicle (HARV) are extracted from dynamic flight data using a maximum likelihood parameter identification technique. The technique uses the linearized aircraft equations of motion in their continuous/discrete form and accounts for state and measurement noise as well as thrust-vectoring effects. State noise is used to model the uncommanded forcing function caused by unsteady aerodynamics over the aircraft, particularly at high angles of attack. Thrust vectoring was implemented using electrohydraulically-actuated nozzle postexit vanes and a specialized research flight control system. During maneuvers, a control system feature provided independent aerodynamic control surface inputs and independent thrust-vectoring vane inputs, thereby eliminating correlations between the aircraft states and controls. Substantial variations in control excitation and dynamic response were exhibited for maneuvers conducted at different angles of attack. Opposing vane interactions caused most thrust-vectoring inputs to experience some exhaust plume interference and thus reduced effectiveness. The estimated stability and control derivatives are plotted, and a discussion relates them to predicted values and maneuver quality.

Characterization of a 3rd Generation Lentiviral Vector Pseudotyped With Nipah Virus Envelope Proteins For Endothelial Cell Transduction

PubMed Central

Witting, Scott R.; Vallanda, Priya; Gamble, Aisha L.

2013-01-01

Lentiviruses are becoming progressively more popular as gene therapy vectors due to their ability to integrate into quiescent cells and recent clinical trial successes. Directing these vectors to specific cell types and limiting off-target transduction in vivo remains a challenge. Replacing the viral envelope proteins responsible for cellular binding, or pseudotyping, remains a common method to improve lentiviral targeting. Here, we describe the development of a high titer, 3rd generation lentiviral vector pseudotyped with Nipah virus fusion protein (NiV-F) and attachment protein (NiV-G). Critical to high titers was truncation of the cytoplasmic domains of both NiV-F and NiV-G. As known targets of wild-type Nipah virus, primary endothelial cells are shown to be effectively transduced by the Nipah pseudotype. In contrast, human CD34+ hematopoietic progenitors were not significantly transduced. Additionally, the Nipah pseudotype has increased stability in human serum compared to VSV pseudotyped lentivirus. These findings suggest that the use of Nipah virus envelope proteins in 3rd generation lentiviral vectors would be a valuable tool for gene delivery targeted to endothelial cells. PMID:23698741

Characterization of a third generation lentiviral vector pseudotyped with Nipah virus envelope proteins for endothelial cell transduction.

PubMed

Witting, S R; Vallanda, P; Gamble, A L

2013-10-01

Lentiviruses are becoming progressively more popular as gene therapy vectors due to their ability to integrate into quiescent cells and recent clinical trial successes. Directing these vectors to specific cell types and limiting off-target transduction in vivo remains a challenge. Replacing the viral envelope proteins responsible for cellular binding, or pseudotyping, remains a common method to improve lentiviral targeting. Here, we describe the development of a high titer, third generation lentiviral vector pseudotyped with Nipah virus fusion protein (NiV-F) and attachment protein (NiV-G). Critical to high titers was truncation of the cytoplasmic domains of both NiV-F and NiV-G. As known targets of wild-type Nipah virus, primary endothelial cells are shown to be effectively transduced by the Nipah pseudotype. In contrast, human CD34+ hematopoietic progenitors were not significantly transduced. Additionally, the Nipah pseudotype has increased stability in human serum compared with vesicular stomatitis virus pseudotyped lentivirus. These findings suggest that the use of Nipah virus envelope proteins in third generation lentiviral vectors would be a valuable tool for gene delivery targeted to endothelial cells.

Heterologous prime-boost regimens with a recombinant chimpanzee adenoviral vector and adjuvanted F4 protein elicit polyfunctional HIV-1-specific T-Cell responses in macaques.

PubMed

Lorin, Clarisse; Vanloubbeeck, Yannick; Baudart, Sébastien; Ska, Michaël; Bayat, Babak; Brauers, Geoffroy; Clarinval, Géraldine; Donner, Marie-Noëlle; Marchand, Martine; Koutsoukos, Marguerite; Mettens, Pascal; Cohen, Joe; Voss, Gerald

2015-01-01

HIV-1-specific CD4+ and CD8+ T lymphocytes are important for HIV-1 replication control. F4/AS01 consists of F4 recombinant fusion protein (containing clade B Gag/p24, Pol/RT, Nef and Gag/p17) formulated in AS01 Adjuvant System, and was shown to induce F4-specific polyfunctional CD4+ T-cell responses in humans. While replication-incompetent recombinant HIV-1/SIV antigen-expressing human adenoviral vectors can elicit high-frequency antigen-specific CD8+ T-cell responses, their use is hampered by widespread pre-existing immunity to human serotypes. Non-human adenovirus serotypes associated with lower prevalence may offer an alternative strategy. We evaluated the immunogenicity of AdC7-GRN ('A'), a recombinant chimpanzee adenovirus type 7 vector expressing clade B Gag, RT and Nef, and F4/AS01 ('P'), when delivered intramuscularly in homologous (PP or AA) and heterologous (AAPP or PPAA) prime-boost regimens, in macaques and mice. Vaccine-induced HIV-1-antigen-specific T cells in peripheral blood (macaques), liver, spleen, and intestinal and genital mucosa (mice) were characterized by intracellular cytokine staining. Vaccine-specific IgG antibodies (macaques) were detected using ELISA. In macaques, only the heterologous prime-boost regimens induced polyfunctional, persistent and balanced CD4+ and CD8+ T-cell responses specific to each HIV-1 vaccine antigen. AdC7-GRN priming increased the polyfunctionality of F4/AS01-induced CD4+ T cells. Approximately 50% of AdC7-GRN-induced memory CD8+ T cells exhibited an effector-memory phenotype. HIV-1-specific antibodies were detected with each regimen. In mice, antigen-specific CD4+ and CD8+ T-cell responses were detected in the mucosal and systemic anatomical compartments assessed. When administered in heterologous prime-boost regimens, AdC7-GRN and F4/AS01 candidate vaccines acted complementarily in inducing potent and persistent peripheral blood HIV-1-specific CD4+ and CD8+ T-cell responses and antibodies in macaques. Besides, adenoviral vector priming modulated the cytokine-expression profile of the protein-induced CD4+ T cells. Each regimen induced HIV-1-specific T-cell responses in systemic/local tissues in mice. This suggests that prime-boost regimens combining adjuvanted protein and low-seroprevalent chimpanzee adenoviral vectors represent an attractive vaccination strategy for clinical evaluation.

Heterologous Prime-Boost Regimens with a Recombinant Chimpanzee Adenoviral Vector and Adjuvanted F4 Protein Elicit Polyfunctional HIV-1-Specific T-Cell Responses in Macaques

PubMed Central

Lorin, Clarisse; Vanloubbeeck, Yannick; Baudart, Sébastien; Ska, Michaël; Bayat, Babak; Brauers, Geoffroy; Clarinval, Géraldine; Donner, Marie-Noëlle; Marchand, Martine; Koutsoukos, Marguerite; Mettens, Pascal; Cohen, Joe; Voss, Gerald

2015-01-01

HIV-1-specific CD4+ and CD8+ T lymphocytes are important for HIV-1 replication control. F4/AS01 consists of F4 recombinant fusion protein (containing clade B Gag/p24, Pol/RT, Nef and Gag/p17) formulated in AS01 Adjuvant System, and was shown to induce F4-specific polyfunctional CD4+ T-cell responses in humans. While replication-incompetent recombinant HIV-1/SIV antigen-expressing human adenoviral vectors can elicit high-frequency antigen-specific CD8+ T-cell responses, their use is hampered by widespread pre-existing immunity to human serotypes. Non-human adenovirus serotypes associated with lower prevalence may offer an alternative strategy. We evaluated the immunogenicity of AdC7-GRN (‘A’), a recombinant chimpanzee adenovirus type 7 vector expressing clade B Gag, RT and Nef, and F4/AS01 (‘P’), when delivered intramuscularly in homologous (PP or AA) and heterologous (AAPP or PPAA) prime-boost regimens, in macaques and mice. Vaccine-induced HIV-1-antigen-specific T cells in peripheral blood (macaques), liver, spleen, and intestinal and genital mucosa (mice) were characterized by intracellular cytokine staining. Vaccine-specific IgG antibodies (macaques) were detected using ELISA. In macaques, only the heterologous prime-boost regimens induced polyfunctional, persistent and balanced CD4+ and CD8+ T-cell responses specific to each HIV-1 vaccine antigen. AdC7-GRN priming increased the polyfunctionality of F4/AS01-induced CD4+ T cells. Approximately 50% of AdC7-GRN-induced memory CD8+ T cells exhibited an effector-memory phenotype. HIV-1-specific antibodies were detected with each regimen. In mice, antigen-specific CD4+ and CD8+ T-cell responses were detected in the mucosal and systemic anatomical compartments assessed. When administered in heterologous prime-boost regimens, AdC7-GRN and F4/AS01 candidate vaccines acted complementarily in inducing potent and persistent peripheral blood HIV-1-specific CD4+ and CD8+ T-cell responses and antibodies in macaques. Besides, adenoviral vector priming modulated the cytokine-expression profile of the protein-induced CD4+ T cells. Each regimen induced HIV-1-specific T-cell responses in systemic/local tissues in mice. This suggests that prime-boost regimens combining adjuvanted protein and low-seroprevalent chimpanzee adenoviral vectors represent an attractive vaccination strategy for clinical evaluation. PMID:25856308

Efficiency of emulsifier-free emulsions and emulsions containing rapeseed lecithin as delivery systems for vectorization and release of coenzyme Q10: physico-chemical properties and in vitro evaluation.

PubMed

Kaci, M; Arab-Tehrany, E; Dostert, G; Desjardins, I; Velot, E; Desobry, S

2016-11-01

To improve the encapsulation and release of coenzyme Q10 (CoQ10), emulsifier-free-emulsions were developed with a new emulsification process using high-frequency ultrasound (HFU) at 1.7MHz. Nano-emulsions containing CoQ10 were prepared with or without rapeseed lecithin as an emulsifier. The emulsions prepared with HFU were compared with an emulsion of CoQ10 containing emulsifier prepared with the same emulsification technique as well as with emulsions prepared with low-frequency ultrasound coupled with high-pressure homogenization (LFU+HPH). The physico-chemical properties of the emulsions were determined by average droplet size measurement with nano-droplet tracking analysis, droplet surface charge with ζ potential measurement, surface tension and rheological behaviour. Emulsions made by LFU+HPH with an emulsifier showed lower droplet sizes due to cavitation generated by the HFU process. Surface tension results showed that there was no significant difference between emulsions containing lecithin emulsifier regardless of the preparation process or the inclusion of CoQ10. In vitro biocompatibility tests were performed on human mesenchymal stem cells in order to show the cytotoxicity of various formulations and the efficiency of CoQ10-loaded emulsions. In vitro tests proved that the vectors were not toxic. Furthermore, CoQ10 facilitated a high rate of cell proliferation and metabolic activity especially when in an emulsifier-free formulation. Copyright © 2016 Elsevier B.V. All rights reserved.

Focusing behavior of the fractal vector optical fields designed by fractal lattice growth model.

PubMed

Gao, Xu-Zhen; Pan, Yue; Zhao, Meng-Dan; Zhang, Guan-Lin; Zhang, Yu; Tu, Chenghou; Li, Yongnan; Wang, Hui-Tian

2018-01-22

We introduce a general fractal lattice growth model, significantly expanding the application scope of the fractal in the realm of optics. This model can be applied to construct various kinds of fractal "lattices" and then to achieve the design of a great diversity of fractal vector optical fields (F-VOFs) combinating with various "bases". We also experimentally generate the F-VOFs and explore their universal focusing behaviors. Multiple focal spots can be flexibly enginnered, and the optical tweezers experiment validates the simulated tight focusing fields, which means that this model allows the diversity of the focal patterns to flexibly trap and manipulate micrometer-sized particles. Furthermore, the recovery performance of the F-VOFs is also studied when the input fields and spatial frequency spectrum are obstructed, and the results confirm the robustness of the F-VOFs in both focusing and imaging processes, which is very useful in information transmission.

Infection of laboratory-colonized Anopheles darlingi mosquitoes by Plasmodium vivax.

PubMed

Moreno, Marta; Tong, Carlos; Guzmán, Mitchel; Chuquiyauri, Raul; Llanos-Cuentas, Alejandro; Rodriguez, Hugo; Gamboa, Dionicia; Meister, Stephan; Winzeler, Elizabeth A; Maguina, Paula; Conn, Jan E; Vinetz, Joseph M

2014-04-01

Anopheles darlingi Root is the most important malaria vector in the Amazonia region of South America. However, continuous propagation of An. darlingi in the laboratory has been elusive, limiting entomological, genetic/genomic, and vector-pathogen interaction studies of this mosquito species. Here, we report the establishment of an An. darlingi colony derived from wild-caught mosquitoes obtained in the northeastern Peruvian Amazon region of Iquitos in the Loreto Department. We show that the numbers of eggs, larvae, pupae, and adults continue to rise at least to the F6 generation. Comparison of feeding Plasmodium vivax ex vivo of F4 and F5 to F1 generation mosquitoes showed the comparable presence of oocysts and sporozoites, with numbers that corresponded to blood-stage asexual parasitemia and gametocytemia, confirming P. vivax vectorial capacity in the colonized mosquitoes. These results provide new avenues for research on An. darlingi biology and study of An. darlingi-Plasmodium interactions.

AC-coupled GaAs microstrip detectors with a new type of integrated bias resistors

NASA Astrophysics Data System (ADS)

Irsigler, R.; Geppert, R.; Göppert, R.; Hornung, M.; Ludwig, J.; Rogalla, M.; Runge, K.; Schmid, Th.; Söldner-Rembold, A.; Webel, M.; Weber, C.

1998-02-01

Full-size single-sided GaAs microstrip detectors with integrated coupling capacitors and bias resistors have been fabricated on 3″ substrate wafers. PECVD deposited SiO 2 and {SiO 2}/{Si 3N 4} layers were used to provide coupling capacitances of 32.5 and 61.6 pF/cm, respectively. The resistors are made of sputtered CERMET using simple lift of technique. The sheet resistivity of 78 kΩ/□ and the thermal coefficient of resistance of less than 4 × 10 -3/°C satisfy the demands of small area biasing resistors, working on a wide temperature range.

Charge density wave properties of the quasi two-dimensional purple molybdenum bronze KMo 6O 17

NASA Astrophysics Data System (ADS)

Balaska, H.; Dumas, J.; Guyot, H.; Mallet, P.; Marcus, J.; Schlenker, C.; Veuillen, J. Y.; Vignolles, D.

2005-06-01

The purple molybdenum bronze KMo 6O 17 is a quasi-two-dimensional compound which shows a Peierls transition towards a commensurate metallic CDW state. Electron spectroscopy (ARUPS), Scanning Tunnelling Microscopy (STM) and spectroscopy (STS) as well as high magnetic field studies are reported. ARUPS studies corroborate the model of the hidden nesting and provide a value of the CDW vector in good agreement with other measurements. STM studies visualize the triple- q CDW in real space. This is consistent with other measurements of the CDW vector. STS studies provide a value of several 10 meV for the average CDW gap. High magnetic field measurements performed in pulsed fields up to 55 T establish that first order transitions to smaller gap states take place at low temperature. These transitions are ascribed to Pauli type coupling. A phase diagram summarizing all observed anomalies and transitions is presented.

A new unified theory of electromagnetic and gravitational interactions

NASA Astrophysics Data System (ADS)

Li, Li-Xin

2016-12-01

In this paper we present a new unified theory of electromagnetic and gravitational interactions. By considering a four-dimensional spacetime as a hypersurface embedded in a five-dimensional bulk spacetime, we derive the complete set of field equations in the four-dimensional spacetime from the fivedimensional Einstein field equation. Besides the Einstein field equation in the four-dimensional spacetime, an electromagnetic field equation is obtained: ∇a F ab - ξ R b a A a = -4π J b with ξ = -2, where F ab is the antisymmetric electromagnetic field tensor defined by the potential vector A a , R ab is the Ricci curvature tensor of the hypersurface, and J a is the electric current density vector. The electromagnetic field equation differs from the Einstein-Maxwell equation by a curvature-coupled term ξ R b a A a , whose presence addresses the problem of incompatibility of the Einstein-Maxwell equation with a universe containing a uniformly distributed net charge, as discussed in a previous paper by the author [L.-X. Li, Gen. Relativ. Gravit. 48, 28 (2016)]. Hence, the new unified theory is physically different from Kaluza-Klein theory and its variants in which the Einstein-Maxwell equation is derived. In the four-dimensional Einstein field equation derived in the new theory, the source term includes the stress-energy tensor of electromagnetic fields as well as the stress-energy tensor of other unidentified matter. Under certain conditions the unidentified matter can be interpreted as a cosmological constant in the four-dimensional spacetime. We argue that, the electromagnetic field equation and hence the unified theory presented in this paper can be tested in an environment with a high mass density, e.g., inside a neutron star or a white dwarf, and in the early epoch of the universe.

In-medium Chiral Perturbation Theory beyond the Mean-Field Approximation

NASA Astrophysics Data System (ADS)

Meißner, Ulf-G.; Oller, José A.; Wirzba, Andreas

2002-04-01

An explicit expression for the generating functional of two-flavor low-energy QCD with external sources in the presence of nonvanishing nucleon densities was derived recently (J. A. Oller, Phys. Rev. C65 (2002) 025204). Within this approach we derive power counting rules for the calculation of in-medium pion properties. We develop the so-called standard rules for residual nucleon energies of the order of the pion mass and a modified scheme (nonstandard counting) for vanishing residual nucleon energies. We also establish the different scales for the range of applicability of this perturbative expansion, which are 6πfπ≃0.7 GeV for standard and 6π2fπ2/2mN≃0.27 GeV for nonstandard counting, respectively. We have performed a systematic analysis of n-point in-medium Green functions up to and including next-to-leading order when the standard rules apply. These include the in-medium contributions to quark condensates, pion propagators, pion masses, and couplings of the axial-vector, vector, and pseudoscalar currents to pions. In particular, we find a mass shift for negatively charged pions in heavy nuclei, ΔMπ-=(18±m 5) MeV, that agrees with recent determinations from deeply bound pionic 207Pb. We have also established the absence of in-medium renormalization in the π0→γγ decay amplitude up to the same order. The study of ππ scattering requires the use of the nonstandard counting and the calculation is done at leading order. Even at that order we establish new contributions not considered so far. We also point toward further possible improvements of this scheme and touch upon its relation to more conventional many-body approaches.

Elastic Gauge Fields in Weyl Semimetals

NASA Astrophysics Data System (ADS)

Cortijo, Alberto; Ferreiros, Yago; Landsteiner, Karl; Hernandez Vozmediano, Maria Angeles

We show that, as it happens in graphene, elastic deformations couple to the electronic degrees of freedom as pseudo gauge fields in Weyl semimetals. We derive the form of the elastic gauge fields in a tight-binding model hosting Weyl nodes and see that this vector electron-phonon coupling is chiral, providing an example of axial gauge fields in three dimensions. As an example of the new response functions that arise associated to these elastic gauge fields, we derive a non-zero phonon Hall viscosity for the neutral system at zero temperature. The axial nature of the fields provides a test of the chiral anomaly in high energy with three axial vector couplings. European Union structural funds and the Comunidad de Madrid MAD2D-CM Program (S2013/MIT-3007).

Application of vector-valued rational approximations to the matrix eigenvalue problem and connections with Krylov subspace methods

NASA Technical Reports Server (NTRS)

Sidi, Avram

1992-01-01

Let F(z) be a vectored-valued function F: C approaches C sup N, which is analytic at z=0 and meromorphic in a neighborhood of z=0, and let its Maclaurin series be given. We use vector-valued rational approximation procedures for F(z) that are based on its Maclaurin series in conjunction with power iterations to develop bona fide generalizations of the power method for an arbitrary N X N matrix that may be diagonalizable or not. These generalizations can be used to obtain simultaneously several of the largest distinct eigenvalues and the corresponding invariant subspaces, and present a detailed convergence theory for them. In addition, it is shown that the generalized power methods of this work are equivalent to some Krylov subspace methods, among them the methods of Arnoldi and Lanczos. Thus, the theory provides a set of completely new results and constructions for these Krylov subspace methods. This theory suggests at the same time a new mode of usage for these Krylov subspace methods that were observed to possess computational advantages over their common mode of usage.

A superhydrophobic cone to facilitate the xenomonitoring of filarial parasites, malaria, and trypanosomes using mosquito excreta/feces.

PubMed

Cook, Darren A N; Pilotte, Nils; Minetti, Corrado; Williams, Steven A; Reimer, Lisa J

2017-11-06

Background: Molecular xenomonitoring (MX), the testing of insect vectors for the presence of human pathogens, has the potential to provide a non-invasive and cost-effective method for monitoring the prevalence of disease within a community. Current MX methods require the capture and processing of large numbers of mosquitoes, particularly in areas of low endemicity, increasing the time, cost and labour required. Screening the excreta/feces (E/F) released from mosquitoes, rather than whole carcasses, improves the throughput by removing the need to discriminate vector species since non-vectors release ingested pathogens in E/F. It also enables larger numbers of mosquitoes to be processed per pool. However, this new screening approach requires a method of efficiently collecting E/F. Methods: We developed a cone with a superhydrophobic surface to allow for the efficient collection of E/F. Using mosquitoes exposed to either Plasmodium falciparum , Brugia malayi or Trypanosoma brucei brucei, we tested the performance of the superhydrophobic cone alongside two other collection methods. Results: All collection methods enabled the detection of DNA from the three parasites. Using the superhydrophobic cone to deposit E/F into a small tube provided the highest number of positive samples (16 out of 18) and facilitated detection of parasite DNA in E/F from individual mosquitoes. Further tests showed that following a simple washing step, the cone can be reused multiple times, further improving its cost-effectiveness. Conclusions: Incorporating the superhydrophobic cone into mosquito traps or holding containers could provide a simple and efficient method for collecting E/F. Where this is not possible, swabbing the container or using the washing method facilitates the detection of the three parasites used in this study.

Recovery of infectious virus from full-length cowpox virus (CPXV) DNA cloned as a bacterial artificial chromosome (BAC)

PubMed Central

2011-01-01

Transmission from pet rats and cats to humans as well as severe infection in felids and other animal species have recently drawn increasing attention to cowpox virus (CPXV). We report the cloning of the entire genome of cowpox virus strain Brighton Red (BR) as a bacterial artificial chromosome (BAC) in Escherichia coli and the recovery of infectious virus from cloned DNA. Generation of a full-length CPXV DNA clone was achieved by first introducing a mini-F vector, which allows maintenance of large circular DNA in E. coli, into the thymidine kinase locus of CPXV by homologous recombination. Circular replication intermediates were then electroporated into E. coli DH10B cells. Upon successful establishment of the infectious BR clone, we modified the full-length clone such that recombination-mediated excision of bacterial sequences can occur upon transfection in eukaryotic cells. This self-excision of the bacterial replicon is made possible by a sequence duplication within mini-F sequences and allows recovery of recombinant virus progeny without remaining marker or vector sequences. The in vitro growth properties of viruses derived from both BAC clones were determined and found to be virtually indistinguishable from those of parental, wild-type BR. Finally, the complete genomic sequence of the infectious clone was determined and the cloned viral genome was shown to be identical to that of the parental virus. In summary, the generated infectious clone will greatly facilitate studies on individual genes and pathogenesis of CPXV. Moreover, the vector potential of CPXV can now be more systematically explored using this newly generated tool. PMID:21314965

Hairy black hole solutions in U(1) gauge-invariant scalar-vector-tensor theories

NASA Astrophysics Data System (ADS)

Heisenberg, Lavinia; Tsujikawa, Shinji

2018-05-01

In U (1) gauge-invariant scalar-vector-tensor theories with second-order equations of motion, we study the properties of black holes (BH) on a static and spherically symmetric background. In shift-symmetric theories invariant under the shift of scalar ϕ → ϕ + c, we show the existence of new hairy BH solutions where a cubic-order scalar-vector interaction gives rise to a scalar hair manifesting itself around the event horizon. In the presence of a quartic-order interaction besides the cubic coupling, there are also regular BH solutions endowed with scalar and vector hairs.

Bright-type and dark-type vector solitons of the (2 + 1)-dimensional spatially modulated quintic nonlinear Schrödinger equation in nonlinear optics and Bose-Einstein condensate

NASA Astrophysics Data System (ADS)

Wu, Hong-Yu; Jiang, Li-Hong

2018-03-01

We study a (2 + 1) -dimensional N -coupled quintic nonlinear Schrödinger equation with spatially modulated nonlinearity and transverse modulation in nonlinear optics and Bose-Einstein condensate, and obtain bright-type and dark-type vector multipole as well as vortex soliton solutions. When the modulation depth q is fixed as 0 and 1, we can construct vector multipole and vortex solitons, respectively. Based on these solutions, we investigate the form and phase characteristics of vector multipole and vortex solitons.

Three-mode coupling interference patterns in the dynamic structure factor of a relaxor ferroelectric

NASA Astrophysics Data System (ADS)

Manley, M. E.; Abernathy, D. L.; Sahul, R.; Stonaha, P. J.; Budai, J. D.

2016-09-01

A longstanding controversy for relaxor ferroelectrics has been the origin of the "waterfall" effect in the phonon dispersion curves, in which low-energy transverse phonons cascade into vertical columns. Originally interpreted as phonons interacting with polar nanoregions (PNRs), it was later explained as an interference effect of coupling damped optic and acoustic phonons. In light of a recently discovered PNR vibrational mode near the "waterfall" wave vector [M. E. Manley, J. W. Lynn, D. L. Abernathy, E. D. Specht, O. Delaire, A. R. Bishop, R. Sahul, and J. D. Budai, Nat. Commun. 5, 3683 (2014), 10.1038/ncomms4683], we have reexamined this feature using neutron scattering on [100]-poled PMN-30%PT [0.6 Pb (M g1 /3N b2 /3 ) O3-0.3 PbTi O3] . We find that the PNR mode couples to both optic and acoustic phonons and that this results in complex patterns in the dynamic structure factor, including intensity pockets and peaks localized in momentum-energy space. These features are fully explained by extending the mode-coupling model to include three coupled damped harmonic oscillators representing the transverse optic, acoustic, and PNR modes.

The structure, mixing angle, mass and couplings of the light scalar f0(500) and f0(980) mesons

NASA Astrophysics Data System (ADS)

Agaev, S. S.; Azizi, K.; Sundu, H.

2018-06-01

The mixing angle, mass and couplings of the light scalar mesons f0 (500) and f0 (980) are calculated in the framework of QCD two-point sum rule approach by assuming that they are tetraquarks with diquark-antidiquark structures. The mesons are treated as mixtures of the heavy | H > = ([ su ] [ s bar u bar ] + [ sd ] [ s bar d bar ]) /√{ 2 } and light | L > = [ ud ] [ u bar d bar ] scalar diquark-antidiquark components. We extract from corresponding sum rules the mixing angles φH and φL of these states and evaluate the masses and couplings of the particles f0 (500) and f0 (980).

A Bivalent Typhoid Live Vector Vaccine Expressing both Chromosome- and Plasmid-Encoded Yersinia pestis Antigens Fully Protects against Murine Lethal Pulmonary Plague Infection

PubMed Central

Wang, Jin Yuan; Carrasco, Jose A.; Lloyd, Scott A.; Mellado-Sanchez, Gabriela; Diaz-McNair, Jovita; Franco, Olga; Buskirk, Amanda D.; Nataro, James P.; Pasetti, Marcela F.

2014-01-01

Live attenuated bacteria hold great promise as multivalent mucosal vaccines against a variety of pathogens. A major challenge of this approach has been the successful delivery of sufficient amounts of vaccine antigens to adequately prime the immune system without overattenuating the live vaccine. Here we used a live attenuated Salmonella enterica serovar Typhi strain to create a bivalent mucosal plague vaccine that produces both the protective F1 capsular antigen of Yersinia pestis and the LcrV protein required for secretion of virulence effector proteins. To reduce the metabolic burden associated with the coexpression of F1 and LcrV within the live vector, we balanced expression of both antigens by combining plasmid-based expression of F1 with chromosomal expression of LcrV from three independent loci. The immunogenicity and protective efficacy of this novel vaccine were assessed in mice by using a heterologous prime-boost immunization strategy and compared to those of a conventional strain in which F1 and LcrV were expressed from a single low-copy-number plasmid. The serum antibody responses to lipopolysaccharide (LPS) induced by the optimized bivalent vaccine were indistinguishable from those elicited by the parent strain, suggesting an adequate immunogenic capacity maintained through preservation of bacterial fitness; in contrast, LPS titers were 10-fold lower in mice immunized with the conventional vaccine strain. Importantly, mice receiving the optimized bivalent vaccine were fully protected against lethal pulmonary challenge. These results demonstrate the feasibility of distributing foreign antigen expression across both chromosomal and plasmid locations within a single vaccine organism for induction of protective immunity. PMID:25332120

Identification of the propionicin F bacteriocin immunity gene (pcfI) and development of a food-grade cloning system for Propionibacterium freudenreichii.

PubMed

Brede, Dag Anders; Lothe, Sheba; Salehian, Zhian; Faye, Therese; Nes, Ingolf F

2007-12-01

This report describes the first functional analysis of a bacteriocin immunity gene from Propionibacterium freudenreichii and its use as a selection marker for food-grade cloning. Cloning of the pcfI gene (previously orf5 [located as part of the pcfABC propionicin F operon]) rendered the sensitive host 1,000-fold more tolerant to the propionicin F bacteriocin. The physiochemical properties of the 127-residue large PcfI protein resemble those of membrane-bound immunity proteins from bacteriocin systems found in lactic acid bacteria. The high level of immunity conferred by pcfI allowed its use as a selection marker for plasmid transformation in P. freudenreichii. Electroporation of P. freudenreichii IFO12426 by use of the pcfI expression plasmid pSL102 and propionicin F selection (200 bacteriocin units/ml) yielded 10(7) transformants/microg DNA. The 2.7-kb P. freudenreichii food-grade cloning vector pSL104 consists of the pLME108 replicon, a multiple cloning site, and pcfI expressed from the constitutive P(pampS) promoter for selection. The pSL104 vector efficiently facilitated cloning of the propionicin T1 bacteriocin in P. freudenreichii. High-level propionicin T1 production (640 BU/ml) was obtained with the IFO12426 strain, and the food-grade propionicin T1 expression plasmid pSL106 was maintained by approximately 91% of the cells over 25 generations in the absence of selection. To the best of our knowledge this is the first report of an efficient cloning system that facilitates the generation of food-grade recombinant P. freudenreichii strains.

Gene therapy using self-complementary Y733F capsid mutant AAV2/8 restores vision in a model of early onset Leber congenital amaurosis.

PubMed

Ku, Cristy A; Chiodo, Vince A; Boye, Sanford L; Goldberg, Andrew F X; Li, Tiansen; Hauswirth, William W; Ramamurthy, Visvanathan

2011-12-01

Defects in the photoreceptor-specific gene aryl hydrocarbon receptor interacting protein-like 1 (Aipl1) are associated with Leber congenital amaurosis (LCA), a childhood blinding disease with early-onset retinal degeneration and vision loss. Furthermore, Aipl1 defects are characterized at the most severe end of the LCA spectrum. The rapid photoreceptor degeneration and vision loss observed in the LCA patient population are mimicked in a mouse model lacking AIPL1. Using this model, we evaluated if gene replacement therapy using recent advancements in adeno-associated viral vectors (AAV) provides advantages in preventing rapid retinal degeneration. Specifically, we demonstrated that the novel self-complementary Y733F capsid mutant AAV2/8 (sc-Y733F-AAV) provided greater preservation of photoreceptors and functional vision in Aipl1 null mice compared with single-stranded AAV2/8. The benefits of sc-Y733F-AAV were evident following viral administration during the active phase of retinal degeneration, where only sc-Y733F-AAV treatment achieved functional vision rescue. This result was likely due to higher and earlier onset of Aipl1 expression. Based on our studies, we conclude that the sc-Y733F-AAV2/8 viral vector, to date, achieves the best rescue for rapid retinal degeneration in Aipl1 null mice. Our results provide important considerations for viral vectors to be used in future gene therapy clinical trials targeting a wider severity spectrum of inherited retinal dystrophies.

Entropic multirelaxation-time lattice Boltzmann method for moving and deforming geometries in three dimensions

NASA Astrophysics Data System (ADS)

Dorschner, B.; Chikatamarla, S. S.; Karlin, I. V.

2017-06-01

Entropic lattice Boltzmann methods have been developed to alleviate intrinsic stability issues of lattice Boltzmann models for under-resolved simulations. Its reliability in combination with moving objects was established for various laminar benchmark flows in two dimensions in our previous work [B. Dorschner, S. Chikatamarla, F. Bösch, and I. Karlin, J. Comput. Phys. 295, 340 (2015), 10.1016/j.jcp.2015.04.017] as well as for three-dimensional one-way coupled simulations of engine-type geometries in B . Dorschner, F. Bösch, S. Chikatamarla, K. Boulouchos, and I. Karlin [J. Fluid Mech. 801, 623 (2016), 10.1017/jfm.2016.448] for flat moving walls. The present contribution aims to fully exploit the advantages of entropic lattice Boltzmann models in terms of stability and accuracy and extends the methodology to three-dimensional cases, including two-way coupling between fluid and structure and then turbulence and deforming geometries. To cover this wide range of applications, the classical benchmark of a sedimenting sphere is chosen first to validate the general two-way coupling algorithm. Increasing the complexity, we subsequently consider the simulation of a plunging SD7003 airfoil in the transitional regime at a Reynolds number of Re =40 000 and, finally, to access the model's performance for deforming geometries, we conduct a two-way coupled simulation of a self-propelled anguilliform swimmer. These simulations confirm the viability of the new fluid-structure interaction lattice Boltzmann algorithm to simulate flows of engineering relevance.

High-resolution vector magnetometry: Piezo-spin-polarization effect and in-plane strain-induced dominating uniaxial magnetic anisotropy in a 200-nm-thick Ni thin film

NASA Astrophysics Data System (ADS)

Benito, L.

2018-04-01

Owing to its high-sensitivity, reliability, fast, versatile and cost-effective operation, vibrating sample magnetometers (VSM) are massively popular characterization instruments at Magnetism laboratories worldwide. Nevertheless, the inherent appearance of synchronous noise represents a major drawback, which critically limits the fine probing of nanometer-sized media. I here report on an innovative approach to eliminate synchronous noise in VSM. This consists of fitting engineered mechanical devices that absorbs vibration energy, dissipating that into heat. Complementarily, a novel transversal pick-up coil system is also presented and analyzed; this detection system has been engineered to enhance the noise-to-signal ratio and optimized for measuring small size thin film samples. The implementation of a combined mechanical and electromagnetic approach enables to notably enhance the VSM performance, achieving a sensitivity better than 1 ×10-6 emu and a resolution below 5 ×10-8 emu, so that the magnetization vector in nanostructured media can be accurately mapped out down to cryogenic temperatures. I lastly show precision magnetometry measurements carried out in an epitaxial (0 0 1)-oriented 200 nm-thick Ni thin film. The analysis reveals the arising of an in-plane dominating strain-induced uniaxial magnetic anisotropy, K2ef = - 6.455kJ m - 3 , and a stunning piezo-spin-polarization effect resulting in a remarkable 10% modulation of the magnetization vector, ∼ 27 emu/cm3, with respect to the cubic lattice axes. Both effects are attributed to the likely existence of an orthorhombic lattice distortion, i.e.εxx -εyy ≈ - 2 ×10-3 . This categorical link enables to assign the observed anisotropic spin-polarization in the Ni overlayer to a two-ion magnetoelastic coupling effect.

Parainfluenza Virus 5 Expressing Wild-Type or Prefusion Respiratory Syncytial Virus (RSV) Fusion Protein Protects Mice and Cotton Rats from RSV Challenge

PubMed Central

Phan, Shannon I.; Zengel, James R.; Wei, Huiling; Li, Zhuo

2017-01-01

ABSTRACT Human respiratory syncytial virus (RSV) is the leading cause of pediatric bronchiolitis and hospitalizations. RSV can also cause severe complications in elderly and immunocompromised individuals. There is no licensed vaccine. We previously generated a parainfluenza virus 5 (PIV5)-vectored vaccine candidate expressing the RSV fusion protein (F) that was immunogenic and protective in mice. In this work, our goal was to improve the original vaccine candidate by modifying the PIV5 vector or by modifying the RSV F antigen. We previously demonstrated that insertion of a foreign gene at the PIV5 small hydrophobic (SH)–hemagglutinin-neuraminidase (HN) junction or deletion of PIV5 SH increased vaccine efficacy. Additionally, other groups have demonstrated that antibodies against the prefusion conformation of RSV F have more potent neutralizing activity than antibodies against the postfusion conformation. Therefore, to improve on our previously developed vaccine candidate, we inserted RSV F at the PIV5 SH-HN gene junction or used RSV F to replace PIV5 SH. We also engineered PIV5 to express a prefusion-stabilized F mutant. The candidates were tested in BALB/c mice via the intranasal route and induced both humoral and cell-mediated immunity. They also protected against RSV infection in the mouse lung. When they were administered intranasally or subcutaneously in cotton rats, the candidates were highly immunogenic and reduced RSV loads in both the upper and lower respiratory tracts. PIV5-RSV F was equally protective when administered intranasally or subcutaneously. In all cases, the prefusion F mutant did not induce higher neutralizing antibody titers than wild-type F. These results show that antibodies against both pre- and postfusion F are important for neutralizing RSV and should be considered when designing a vectored RSV vaccine. The findings also that indicate PIV5-RSV F may be administered subcutaneously, which is the preferred route for vaccinating infants, who may develop nasal congestion as a result of intranasal vaccination. IMPORTANCE Despite decades of research, human respiratory syncytial virus (RSV) is still a major health concern for which there is no vaccine. A parainfluenza virus 5-vectored vaccine expressing the native RSV fusion protein (F) has previously been shown to confer robust immunity against RSV infection in mice, cotton rats, and nonhuman primates. To improve our previous vaccine candidate, we developed four new candidates that incorporate modifications to the PIV5 backbone, replace native RSV F with a prefusion-stabilized RSV F mutant, or combine both RSV F and PIV5 backbone modifications. In this work, we characterized the new vaccine candidates and tested their efficacies in both murine and cotton rat models of RSV infection. Most importantly, we found that PIV5-based RSV vaccine candidates were efficacious in preventing lower respiratory tract infection as well as in reducing the nasal viral load when administered via the subcutaneous route. PMID:28747496

Parainfluenza Virus 5 Expressing Wild-Type or Prefusion Respiratory Syncytial Virus (RSV) Fusion Protein Protects Mice and Cotton Rats from RSV Challenge.

PubMed

Phan, Shannon I; Zengel, James R; Wei, Huiling; Li, Zhuo; Wang, Dai; He, Biao

2017-10-01

Human respiratory syncytial virus (RSV) is the leading cause of pediatric bronchiolitis and hospitalizations. RSV can also cause severe complications in elderly and immunocompromised individuals. There is no licensed vaccine. We previously generated a parainfluenza virus 5 (PIV5)-vectored vaccine candidate expressing the RSV fusion protein (F) that was immunogenic and protective in mice. In this work, our goal was to improve the original vaccine candidate by modifying the PIV5 vector or by modifying the RSV F antigen. We previously demonstrated that insertion of a foreign gene at the PIV5 small hydrophobic (SH)-hemagglutinin-neuraminidase (HN) junction or deletion of PIV5 SH increased vaccine efficacy. Additionally, other groups have demonstrated that antibodies against the prefusion conformation of RSV F have more potent neutralizing activity than antibodies against the postfusion conformation. Therefore, to improve on our previously developed vaccine candidate, we inserted RSV F at the PIV5 SH-HN gene junction or used RSV F to replace PIV5 SH. We also engineered PIV5 to express a prefusion-stabilized F mutant. The candidates were tested in BALB/c mice via the intranasal route and induced both humoral and cell-mediated immunity. They also protected against RSV infection in the mouse lung. When they were administered intranasally or subcutaneously in cotton rats, the candidates were highly immunogenic and reduced RSV loads in both the upper and lower respiratory tracts. PIV5-RSV F was equally protective when administered intranasally or subcutaneously. In all cases, the prefusion F mutant did not induce higher neutralizing antibody titers than wild-type F. These results show that antibodies against both pre- and postfusion F are important for neutralizing RSV and should be considered when designing a vectored RSV vaccine. The findings also that indicate PIV5-RSV F may be administered subcutaneously, which is the preferred route for vaccinating infants, who may develop nasal congestion as a result of intranasal vaccination. IMPORTANCE Despite decades of research, human respiratory syncytial virus (RSV) is still a major health concern for which there is no vaccine. A parainfluenza virus 5-vectored vaccine expressing the native RSV fusion protein (F) has previously been shown to confer robust immunity against RSV infection in mice, cotton rats, and nonhuman primates. To improve our previous vaccine candidate, we developed four new candidates that incorporate modifications to the PIV5 backbone, replace native RSV F with a prefusion-stabilized RSV F mutant, or combine both RSV F and PIV5 backbone modifications. In this work, we characterized the new vaccine candidates and tested their efficacies in both murine and cotton rat models of RSV infection. Most importantly, we found that PIV5-based RSV vaccine candidates were efficacious in preventing lower respiratory tract infection as well as in reducing the nasal viral load when administered via the subcutaneous route. Copyright © 2017 American Society for Microbiology.

Actin cytoskeleton rearrangements in Arabidopsis roots under stress and during gravitropic response

NASA Astrophysics Data System (ADS)

Pozhvanov, Gregory; Medvedev, Sergei; Suslov, Dmitry; Demidchik, Vadim

Among environmental factors, gravity vector is the only one which is constant in direction and accompanies the whole plant ontogenesis. That said, gravity vector can be considered as an essential factor for correct development of plants. Gravitropism is a plant growth response against changing its position relative to the gravity vector. It is well estableshed that gravitropism is directed by auxin redistribution across the gravistimulated organ. In addition to auxin, actin cytoskeleton was shown to be involved in gravitropism at different stages: gravity perception, signal transduction and gravitropic bending formation. However, the relationship between IAA and actin is still under discussion. In this work we studied rearrangements of actin cytoskeleton during root gravitropic response. Actin microfilaments were visualized in vivo in GFP-fABD2 transgenic Arabidopsis plants, and their angle distribution was acquired from MicroFilament Analyzer software. The curvature of actin microfilaments in root elongation zone was shown to be increased within 30-60 min of gravistimulation, the fraction of axially oriented microfilaments decreased with a concomitant increase in the fraction of oblique and transversally oriented microfilaments. In particular, the fraction of transversally oriented microfilaments (i.e. parallel to the gravity vector) increased 3-5 times. Under 10 min of sub-lethal salt stress impact, actin microfilament orientations widened from an initial axial orientation to a set of peaks at 15(°) , 45(°) and 90(°) . We conclude that the actin cytoskeleton rearrangements observed are associated with the regulation of basic mechanisms of cell extension growth by which the gravitropic bending is formed. Having common stress-related features, gravity-induced actin cytoskeleton rearrangement is slower but results in higher number of g-vector-parallel microfilaments when compared to salt stress-induced rearrangement. Also, differences in gravistimulated root growth between wild type and GFP-fABD2 plants are discussed. Project was supported by the OPTEC / Carl Zeiss Personal grant to G.P. (2012), grants of Russian Foundation for Basic Research (11-04-00701a, 14-04-01624a) and by the grant of St.-Petersburg State University (1.38.233.2014).

Ion Energy and Ion Flux Distributions of CF4/Ar/O2 Inductively Coupled Plasmas in a GEC Cell

NASA Technical Reports Server (NTRS)

Rao, M. V. V. S.; Cruden, Brett; Sharma, Surendra; Meyyappan, Meyya

2001-01-01

Knowledge of ion kinetics in plasma processing gas mixtures, such as CF4:Ar:O2, is important for understanding plasma assisted etching and deposition of materials. Ion energies and ion fluxes were measured in this mixture for 80:10:10, 60:20:20, and 40:30:30 mixture ratios in the pressure range of 10-50 mTorr, and at 200 and 300 W of RF power. Ions from plasma, sampled through a 10 micron orifice in the center of the lower plane electrode, were energy and mass analyzed by a combination of electrostatic energy and quadrupole mass filters. CFx(+) (x = 1 - 3), F2(+), F(+), C(+) from CF4, Ar(+) from Ar, and O2(+) and O(+) from O2, and by-product ions SiFx(+)(x = 1 - 3) from etching of quartz coupling window, COFx(+)(x = 1 - 3), CO(+), CO2(+), and OF(+) were detected. In all conditions ion flux decreases with increase of pressure but increase with increase of RF power. Ar(+) signal decreases with increase of pressure while CF3(+), which is the dominant ion at all conditions, increases with increase in pressure. The loss mechanism for Ar(+) and increase of CF3(+) is due to large cross section for Ar(+) + CF4 yields Ar + CF3(+) + F. Ion energies, which range from 15-25 eV depending on plasma operating conditions, are nearly Gaussian. By-product ion signals are higher at lower pressures indicating stronger plasma interaction with quartz window.

Subsonic longitudinal aerodynamic characteristics of a vectored-engine-over-wing configuration having spanwise leading-edge vortex enhancement

NASA Technical Reports Server (NTRS)

Huffman, J. K.; Fox, C. H., Jr.

1977-01-01

A configuration which integrates a close coupled canard wing combination, spanwise blowing for enhancement of the wing leading edge vortex, an engine-over-wing concept, and a wing trailing edge coanda-effect flap is studied. The data on the configuration are presented in tabular from without discussion. The investigation was conducted in the Langley 7- by 10-foot high speed tunnel at a Mach number of 0.166 through an angle-of-attack range from -2 to 22 deg. Rectangular main engine nozzles of aspect ratio 4, 6, and 8 were tested over a momentum coefficient range from 1.0 to 1.8.

Distributed effects of methylphenidate on the network structure of the resting brain: a connectomic pattern classification analysis.

PubMed

Sripada, Chandra Sekhar; Kessler, Daniel; Welsh, Robert; Angstadt, Michael; Liberzon, Israel; Phan, K Luan; Scott, Clayton

2013-11-01

Methylphenidate is a psychostimulant medication that produces improvements in functions associated with multiple neurocognitive systems. To investigate the potentially distributed effects of methylphenidate on the brain's intrinsic network architecture, we coupled resting state imaging with multivariate pattern classification. In a within-subject, double-blind, placebo-controlled, randomized, counterbalanced, cross-over design, 32 healthy human volunteers received either methylphenidate or placebo prior to two fMRI resting state scans separated by approximately one week. Resting state connectomes were generated by placing regions of interest at regular intervals throughout the brain, and these connectomes were submitted for support vector machine analysis. We found that methylphenidate produces a distributed, reliably detected, multivariate neural signature. Methylphenidate effects were evident across multiple resting state networks, especially visual, somatomotor, and default networks. Methylphenidate reduced coupling within visual and somatomotor networks. In addition, default network exhibited decoupling with several task positive networks, consistent with methylphenidate modulation of the competitive relationship between these networks. These results suggest that connectivity changes within and between large-scale networks are potentially involved in the mechanisms by which methylphenidate improves attention functioning. Copyright © 2013 Elsevier Inc. All rights reserved.

Search for WWγ and WZγ production and constraints on anomalous quartic gauge couplings in pp collisions at √s =8 TeV

NASA Astrophysics Data System (ADS)

Chatrchyan, S.; Khachatryan, V.; Sirunyan, A. M.; Tumasyan, A.; Adam, W.; Bergauer, T.; Dragicevic, M.; Erö, J.; Fabjan, C.; Friedl, M.; Frühwirth, R.; Ghete, V. M.; Hartl, C.; Hörmann, N.; Hrubec, J.; Jeitler, M.; Kiesenhofer, W.; Knünz, V.; Krammer, M.; Krätschmer, I.; Liko, D.; Mikulec, I.; Rabady, D.; Rahbaran, B.; Rohringer, H.; Schöfbeck, R.; Strauss, J.; Taurok, A.; Treberer-Treberspurg, W.; Waltenberger, W.; Wulz, C.-E.; Mossolov, V.; Shumeiko, N.; Suarez Gonzalez, J.; Alderweireldt, S.; Bansal, M.; Bansal, S.; Cornelis, T.; De Wolf, E. A.; Janssen, X.; Knutsson, A.; Luyckx, S.; Ochesanu, S.; Roland, B.; Rougny, R.; Van Haevermaet, H.; Van Mechelen, P.; Van Remortel, N.; Van Spilbeeck, A.; Blekman, F.; Blyweert, S.; D'Hondt, J.; Heracleous, N.; Kalogeropoulos, A.; Keaveney, J.; Kim, T. J.; Lowette, S.; Maes, M.; Olbrechts, A.; Python, Q.; Strom, D.; Tavernier, S.; Van Doninck, W.; Van Mulders, P.; Van Onsem, G. P.; Villella, I.; Caillol, C.; Clerbaux, B.; De Lentdecker, G.; Favart, L.; Gay, A. P. R.; Léonard, A.; Marage, P. E.; Mohammadi, A.; Perniè, L.; Reis, T.; Seva, T.; Thomas, L.; Vander Velde, C.; Vanlaer, P.; Wang, J.; Adler, V.; Beernaert, K.; Benucci, L.; Cimmino, A.; Costantini, S.; Crucy, S.; Dildick, S.; Garcia, G.; Klein, B.; Lellouch, J.; Mccartin, J.; Ocampo Rios, A. A.; Ryckbosch, D.; Salva Diblen, S.; Sigamani, M.; Strobbe, N.; Thyssen, F.; Tytgat, M.; Walsh, S.; Yazgan, E.; Zaganidis, N.; Basegmez, S.; Beluffi, C.; Bruno, G.; Castello, R.; Caudron, A.; Ceard, L.; Da Silveira, G. G.; Delaere, C.; du Pree, T.; Favart, D.; Forthomme, L.; Giammanco, A.; Hollar, J.; Jez, P.; Komm, M.; Lemaitre, V.; Liao, J.; Militaru, O.; Nuttens, C.; Pagano, D.; Pin, A.; Piotrzkowski, K.; Popov, A.; Quertenmont, L.; Selvaggi, M.; Vidal Marono, M.; Vizan Garcia, J. M.; Beliy, N.; Caebergs, T.; Daubie, E.; Hammad, G. H.; Alves, G. A.; Brito, L.; Correa Martins Junior, M.; Pol, M. E.; Rebello Teles, P.; Aldá Júnior, W. L.; Carvalho, W.; Chinellato, J.; Custódio, A.; Da Costa, E. M.; De Jesus Damiao, D.; De Oliveira Martins, C.; Fonseca De Souza, S.; Malbouisson, H.; Malek, M.; Matos Figueiredo, D.; Mundim, L.; Nogima, H.; Prado Da Silva, W. L.; Santaolalla, J.; Santoro, A.; Sznajder, A.; Tonelli Manganote, E. J.; Vilela Pereira, A.; Bernardes, C. A.; Dias, F. A.; Fernandez Perez Tomei, T. R.; Gregores, E. M.; Mercadante, P. G.; Novaes, S. F.; Padula, Sandra S.; Genchev, V.; Iaydjiev, P.; Marinov, A.; Piperov, S.; Rodozov, M.; Sultanov, G.; Vutova, M.; Dimitrov, A.; Glushkov, I.; Hadjiiska, R.; Kozhuharov, V.; Litov, L.; Pavlov, B.; Petkov, P.; Bian, J. G.; Chen, G. M.; Chen, H. S.; Chen, M.; Du, R.; Jiang, C. H.; Liang, D.; Liang, S.; Meng, X.; Plestina, R.; Tao, J.; Wang, X.; Wang, Z.; Asawatangtrakuldee, C.; Ban, Y.; Guo, Y.; Li, Q.; Li, W.; Liu, S.; Mao, Y.; Qian, S. J.; Wang, D.; Yang, D.; Zhang, L.; Zou, W.; Avila, C.; Chaparro Sierra, L. F.; Florez, C.; Gomez, J. P.; Gomez Moreno, B.; Sanabria, J. C.; Godinovic, N.; Lelas, D.; Polic, D.; Puljak, I.; Antunovic, Z.; Kovac, M.; Brigljevic, V.; Kadija, K.; Luetic, J.; Mekterovic, D.; Morovic, S.; Tikvica, L.; Attikis, A.; Mavromanolakis, G.; Mousa, J.; Nicolaou, C.; Ptochos, F.; Razis, P. A.; Bodlak, M.; Finger, M.; Finger, M.; Assran, Y.; Elgammal, S.; Ellithi Kamel, A.; Mahmoud, M. A.; Mahrous, A.; Radi, A.; Kadastik, M.; Müntel, M.; Murumaa, M.; Raidal, M.; Tiko, A.; Eerola, P.; Fedi, G.; Voutilainen, M.; Härkönen, J.; Karimäki, V.; Kinnunen, R.; Kortelainen, M. J.; Lampén, T.; Lassila-Perini, K.; Lehti, S.; Lindén, T.; Luukka, P.; Mäenpää, T.; Peltola, T.; Tuominen, E.; Tuominiemi, J.; Tuovinen, E.; Wendland, L.; Tuuva, T.; Besancon, M.; Couderc, F.; Dejardin, M.; Denegri, D.; Fabbro, B.; Faure, J. L.; Favaro, C.; Ferri, F.; Ganjour, S.; Givernaud, A.; Gras, P.; Hamel de Monchenault, G.; Jarry, P.; Locci, E.; Malcles, J.; Nayak, A.; Rander, J.; Rosowsky, A.; Titov, M.; Baffioni, S.; Beaudette, F.; Busson, P.; Charlot, C.; Daci, N.; Dahms, T.; Dalchenko, M.; Dobrzynski, L.; Filipovic, N.; Florent, A.; Granier de Cassagnac, R.; Mastrolorenzo, L.; Miné, P.; Mironov, C.; Naranjo, I. N.; Nguyen, M.; Ochando, C.; Paganini, P.; Sabes, D.; Salerno, R.; Sauvan, J. b.; Sirois, Y.; Veelken, C.; Yilmaz, Y.; Zabi, A.; Agram, J.-L.; Andrea, J.; Bloch, D.; Brom, J.-M.; Chabert, E. C.; Collard, C.; Conte, E.; Drouhin, F.; Fontaine, J.-C.; Gelé, D.; Goerlach, U.; Goetzmann, C.; Juillot, P.; Le Bihan, A.-C.; Van Hove, P.; Gadrat, S.; Beauceron, S.; Beaupere, N.; Boudoul, G.; Brochet, S.; Carrillo Montoya, C. A.; Chasserat, J.; Chierici, R.; Contardo, D.; Depasse, P.; El Mamouni, H.; Fan, J.; Fay, J.; Gascon, S.; Gouzevitch, M.; Ille, B.; Kurca, T.; Lethuillier, M.; Mirabito, L.; Perries, S.; Ruiz Alvarez, J. D.; Sgandurra, L.; Sordini, V.; Vander Donckt, M.; Verdier, P.; Viret, S.; Xiao, H.; Rurua, L.; Autermann, C.; Beranek, S.; Bontenackels, M.; Calpas, B.; Edelhoff, M.; Feld, L.; Hindrichs, O.; Klein, K.; Ostapchuk, A.; Perieanu, A.; Raupach, F.; Sammet, J.; Schael, S.; Sprenger, D.; Weber, H.; Wittmer, B.; Zhukov, V.; Ata, M.; Caudron, J.; Dietz-Laursonn, E.; Duchardt, D.; Erdmann, M.; Fischer, R.; Güth, A.; Hebbeker, T.; Heidemann, C.; Hoepfner, K.; Klingebiel, D.; Knutzen, S.; Kreuzer, P.; Merschmeyer, M.; Meyer, A.; Olschewski, M.; Padeken, K.; Papacz, P.; Reithler, H.; Schmitz, S. A.; Sonnenschein, L.; Teyssier, D.; Thüer, S.; Weber, M.; Cherepanov, V.; Erdogan, Y.; Flügge, G.; Geenen, H.; Geisler, M.; Haj Ahmad, W.; Hoehle, F.; Kargoll, B.; Kress, T.; Kuessel, Y.; Lingemann, J.; Nowack, A.; Nugent, I. M.; Perchalla, L.; Pooth, O.; Stahl, A.; Asin, I.; Bartosik, N.; Behr, J.; Behrenhoff, W.; Behrens, U.; Bell, A. J.; Bergholz, M.; Bethani, A.; Borras, K.; Burgmeier, A.; Cakir, A.; Calligaris, L.; Campbell, A.; Choudhury, S.; Costanza, F.; Diez Pardos, C.; Dooling, S.; Dorland, T.; Eckerlin, G.; Eckstein, D.; Eichhorn, T.; Flucke, G.; Garay Garcia, J.; Geiser, A.; Grebenyuk, A.; Gunnellini, P.; Habib, S.; Hauk, J.; Hellwig, G.; Hempel, M.; Horton, D.; Jung, H.; Kasemann, M.; Katsas, P.; Kieseler, J.; Kleinwort, C.; Krämer, M.; Krücker, D.; Lange, W.; Leonard, J.; Lipka, K.; Lohmann, W.; Lutz, B.; Mankel, R.; Marfin, I.; Melzer-Pellmann, I.-A.; Meyer, A. B.; Mnich, J.; Mussgiller, A.; Naumann-Emme, S.; Novgorodova, O.; Nowak, F.; Ntomari, E.; Perrey, H.; Petrukhin, A.; Pitzl, D.; Placakyte, R.; Raspereza, A.; Ribeiro Cipriano, P. M.; Riedl, C.; Ron, E.; Sahin, M. Ö.; Salfeld-Nebgen, J.; Saxena, P.; Schmidt, R.; Schoerner-Sadenius, T.; Schröder, M.; Stein, M.; Vargas Trevino, A. D. R.; Walsh, R.; Wissing, C.; Aldaya Martin, M.; Blobel, V.; Centis Vignali, M.; Enderle, H.; Erfle, J.; Garutti, E.; Goebel, K.; Görner, M.; Gosselink, M.; Haller, J.; Höing, R. S.; Kirschenmann, H.; Klanner, R.; Kogler, R.; Lange, J.; Lapsien, T.; Lenz, T.; Marchesini, I.; Ott, J.; Peiffer, T.; Pietsch, N.; Rathjens, D.; Sander, C.; Schettler, H.; Schleper, P.; Schlieckau, E.; Schmidt, A.; Seidel, M.; Sibille, J.; Sola, V.; Stadie, H.; Steinbrück, G.; Troendle, D.; Usai, E.; Vanelderen, L.; Barth, C.; Baus, C.; Berger, J.; Böser, C.; Butz, E.; Chwalek, T.; De Boer, W.; Descroix, A.; Dierlamm, A.; Feindt, M.; Guthoff, M.; Hartmann, F.; Hauth, T.; Held, H.; Hoffmann, K. H.; Husemann, U.; Katkov, I.; Kornmayer, A.; Kuznetsova, E.; Lobelle Pardo, P.; Martschei, D.; Mozer, M. U.; Müller, Th.; Niegel, M.; Nürnberg, A.; Oberst, O.; Quast, G.; Rabbertz, K.; Ratnikov, F.; Röcker, S.; Schilling, F.-P.; Schott, G.; Simonis, H. J.; Stober, F. M.; Ulrich, R.; Wagner-Kuhr, J.; Wayand, S.; Weiler, T.; Wolf, R.; Zeise, M.; Anagnostou, G.; Daskalakis, G.; Geralis, T.; Giakoumopoulou, V. A.; Kesisoglou, S.; Kyriakis, A.; Loukas, D.; Markou, A.; Markou, C.; Psallidas, A.; Topsis-Giotis, I.; Gouskos, L.; Panagiotou, A.; Saoulidou, N.; Stiliaris, E.; Aslanoglou, X.; Evangelou, I.; Flouris, G.; Foudas, C.; Jones, J.; Kokkas, P.; Manthos, N.; Papadopoulos, I.; Paradas, E.; Bencze, G.; Hajdu, C.; Hidas, P.; Horvath, D.; Sikler, F.; Veszpremi, V.; Vesztergombi, G.; Zsigmond, A. J.; Beni, N.; Czellar, S.; Karancsi, J.; Molnar, J.; Palinkas, J.; Szillasi, Z.; Raics, P.; Trocsanyi, Z. L.; Ujvari, B.; Swain, S. K.; Beri, S. B.; Bhatnagar, V.; Dhingra, N.; Gupta, R.; Kalsi, A. K.; Kaur, M.; Mittal, M.; Nishu, N.; Sharma, A.; Singh, J. B.; Kumar, Ashok; Kumar, Arun; Ahuja, S.; Bhardwaj, A.; Choudhary, B. C.; Kumar, A.; Malhotra, S.; Naimuddin, M.; Ranjan, K.; Sharma, V.; Shivpuri, R. K.; Banerjee, S.; Bhattacharya, S.; Chatterjee, K.; Dutta, S.; Gomber, B.; Jain, Sa.; Jain, Sh.; Khurana, R.; Modak, A.; Mukherjee, S.; Roy, D.; Sarkar, S.; Sharan, M.; Singh, A. 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C.; Bonacorsi, D.; Braibant-Giacomelli, S.; Brigliadori, L.; Campanini, R.; Capiluppi, P.; Castro, A.; Cavallo, F. R.; Codispoti, G.; Cuffiani, M.; Dallavalle, G. M.; Fabbri, F.; Fanfani, A.; Fasanella, D.; Giacomelli, P.; Grandi, C.; Guiducci, L.; Marcellini, S.; Masetti, G.; Meneghelli, M.; Montanari, A.; Navarria, F. L.; Odorici, F.; Perrotta, A.; Primavera, F.; Rossi, A. M.; Rovelli, T.; Siroli, G. P.; Tosi, N.; Travaglini, R.; Albergo, S.; Cappello, G.; Chiorboli, M.; Costa, S.; Giordano, F.; Potenza, R.; Tricomi, A.; Tuve, C.; Barbagli, G.; Ciulli, V.; Civinini, C.; D'Alessandro, R.; Focardi, E.; Gallo, E.; Gonzi, S.; Gori, V.; Lenzi, P.; Meschini, M.; Paoletti, S.; Sguazzoni, G.; Tropiano, A.; Benussi, L.; Bianco, S.; Fabbri, F.; Piccolo, D.; Fabbricatore, P.; Ferro, F.; Lo Vetere, M.; Musenich, R.; Robutti, E.; Tosi, S.; Dinardo, M. E.; Fiorendi, S.; Gennai, S.; Gerosa, R.; Ghezzi, A.; Govoni, P.; Lucchini, M. T.; Malvezzi, S.; Manzoni, R. A.; Martelli, A.; Marzocchi, B.; Menasce, D.; Moroni, L.; Paganoni, M.; Pedrini, D.; Ragazzi, S.; Redaelli, N.; Tabarelli de Fatis, T.; Buontempo, S.; Cavallo, N.; Di Guida, S.; Fabozzi, F.; Iorio, A. O. M.; Lista, L.; Meola, S.; Merola, M.; Paolucci, P.; Azzi, P.; Bacchetta, N.; Bisello, D.; Branca, A.; Carlin, R.; Checchia, P.; Dorigo, T.; Galanti, M.; Gasparini, F.; Gasparini, U.; Gozzelino, A.; Kanishchev, K.; Lacaprara, S.; Lazzizzera, I.; Margoni, M.; Meneguzzo, A. T.; Pazzini, J.; Pozzobon, N.; Ronchese, P.; Sgaravatto, M.; Simonetto, F.; Torassa, E.; Tosi, M.; Triossi, A.; Ventura, S.; Zotto, P.; Zucchetta, A.; Gabusi, M.; Ratti, S. P.; Riccardi, C.; Salvini, P.; Vitulo, P.; Biasini, M.; Bilei, G. M.; Fanò, L.; Lariccia, P.; Mantovani, G.; Menichelli, M.; Romeo, F.; Saha, A.; Santocchia, A.; Spiezia, A.; Androsov, K.; Azzurri, P.; Bagliesi, G.; Bernardini, J.; Boccali, T.; Broccolo, G.; Castaldi, R.; Ciocci, M. 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V.; Vinogradov, A.; Belyaev, A.; Boos, E.; Dubinin, M.; Dudko, L.; Ershov, A.; Gribushin, A.; Klyukhin, V.; Kodolova, O.; Lokhtin, I.; Obraztsov, S.; Petrushanko, S.; Savrin, V.; Snigirev, A.; Azhgirey, I.; Bayshev, I.; Bitioukov, S.; Kachanov, V.; Kalinin, A.; Konstantinov, D.; Krychkine, V.; Petrov, V.; Ryutin, R.; Sobol, A.; Tourtchanovitch, L.; Troshin, S.; Tyurin, N.; Uzunian, A.; Volkov, A.; Adzic, P.; Djordjevic, M.; Ekmedzic, M.; Milosevic, J.; Aguilar-Benitez, M.; Alcaraz Maestre, J.; Battilana, C.; Calvo, E.; Cerrada, M.; Chamizo Llatas, M.; Colino, N.; De La Cruz, B.; Delgado Peris, A.; Domínguez Vázquez, D.; Escalante Del Valle, A.; Fernandez Bedoya, C.; Fernández Ramos, J. P.; Ferrando, A.; Flix, J.; Fouz, M. C.; Garcia-Abia, P.; Gonzalez Lopez, O.; Goy Lopez, S.; Hernandez, J. M.; Josa, M. I.; Merino, G.; Navarro De Martino, E.; Pérez-Calero Yzquierdo, A.; Puerta Pelayo, J.; Quintario Olmeda, A.; Redondo, I.; Romero, L.; Soares, M. S.; Willmott, C.; Albajar, C.; de Trocóniz, J. F.; Missiroli, M.; Brun, H.; Cuevas, J.; Fernandez Menendez, J.; Folgueras, S.; Gonzalez Caballero, I.; Lloret Iglesias, L.; Brochero Cifuentes, J. A.; Cabrillo, I. J.; Calderon, A.; Duarte Campderros, J.; Fernandez, M.; Gomez, G.; Gonzalez Sanchez, J.; Graziano, A.; Lopez Virto, A.; Marco, J.; Marco, R.; Martinez Rivero, C.; Matorras, F.; Munoz Sanchez, F. J.; Piedra Gomez, J.; Rodrigo, T.; Rodríguez-Marrero, A. Y.; Ruiz-Jimeno, A.; Scodellaro, L.; Vila, I.; Vilar Cortabitarte, R.; Abbaneo, D.; Auffray, E.; Auzinger, G.; Bachtis, M.; Baillon, P.; Ball, A. H.; Barney, D.; Benaglia, A.; Bendavid, J.; Benhabib, L.; Benitez, J. F.; Bernet, C.; Bianchi, G.; Bloch, P.; Bocci, A.; Bonato, A.; Bondu, O.; Botta, C.; Breuker, H.; Camporesi, T.; Cerminara, G.; Christiansen, T.; Coarasa Perez, J. A.; Colafranceschi, S.; D'Alfonso, M.; d'Enterria, D.; Dabrowski, A.; David, A.; De Guio, F.; De Roeck, A.; De Visscher, S.; Dobson, M.; Dupont-Sagorin, N.; Elliott-Peisert, A.; Eugster, J.; Franzoni, G.; Funk, W.; Giffels, M.; Gigi, D.; Gill, K.; Giordano, D.; Girone, M.; Giunta, M.; Glege, F.; Gomez-Reino Garrido, R.; Gowdy, S.; Guida, R.; Hammer, J.; Hansen, M.; Harris, P.; Hegeman, J.; Innocente, V.; Janot, P.; Karavakis, E.; Kousouris, K.; Krajczar, K.; Lecoq, P.; Lourenço, C.; Magini, N.; Malgeri, L.; Mannelli, M.; Masetti, L.; Meijers, F.; Mersi, S.; Meschi, E.; Moortgat, F.; Mulders, M.; Musella, P.; Orsini, L.; Palencia Cortezon, E.; Pape, L.; Perez, E.; Perrozzi, L.; Petrilli, A.; Petrucciani, G.; Pfeiffer, A.; Pierini, M.; Pimiä, M.; Piparo, D.; Plagge, M.; Racz, A.; Reece, W.; Rolandi, G.; Rovere, M.; Sakulin, H.; Santanastasio, F.; Schäfer, C.; Schwick, C.; Sekmen, S.; Sharma, A.; Siegrist, P.; Silva, P.; Simon, M.; Sphicas, P.; Spiga, D.; Steggemann, J.; Stieger, B.; Stoye, M.; Treille, D.; Tsirou, A.; Veres, G. I.; Vlimant, J. R.; Wöhri, H. K.; Zeuner, W. D.; Bertl, W.; Deiters, K.; Erdmann, W.; Horisberger, R.; Ingram, Q.; Kaestli, H. C.; König, S.; Kotlinski, D.; Langenegger, U.; Renker, D.; Rohe, T.; Bachmair, F.; Bäni, L.; Bianchini, L.; Bortignon, P.; Buchmann, M. A.; Casal, B.; Chanon, N.; Deisher, A.; Dissertori, G.; Dittmar, M.; Donegà, M.; Dünser, M.; Eller, P.; Grab, C.; Hits, D.; Lustermann, W.; Mangano, B.; Marini, A. C.; Martinez Ruiz del Arbol, P.; Meister, D.; Mohr, N.; Nägeli, C.; Nef, P.; Nessi-Tedaldi, F.; Pandolfi, F.; Pauss, F.; Peruzzi, M.; Quittnat, M.; Rebane, L.; Ronga, F. J.; Rossini, M.; Starodumov, A.; Takahashi, M.; Theofilatos, K.; Wallny, R.; Weber, H. A.; Amsler, C.; Canelli, M. F.; Chiochia, V.; De Cosa, A.; Hinzmann, A.; Hreus, T.; Ivova Rikova, M.; Kilminster, B.; Millan Mejias, B.; Ngadiuba, J.; Robmann, P.; Snoek, H.; Taroni, S.; Verzetti, M.; Yang, Y.; Cardaci, M.; Chen, K. H.; Ferro, C.; Kuo, C. M.; Li, S. W.; Lin, W.; Lu, Y. J.; Volpe, R.; Yu, S. S.; Bartalini, P.; Chang, P.; Chang, Y. H.; Chang, Y. W.; Chao, Y.; Chen, K. F.; Chen, P. H.; Dietz, C.; Grundler, U.; Hou, W.-S.; Hsiung, Y.; Kao, K. Y.; Lei, Y. J.; Liu, Y. F.; Lu, R.-S.; Majumder, D.; Petrakou, E.; Shi, X.; Shiu, J. G.; Tzeng, Y. M.; Wang, M.; Wilken, R.; Asavapibhop, B.; Simili, E.; Adiguzel, A.; Bakirci, M. N.; Cerci, S.; Dozen, C.; Dumanoglu, I.; Eskut, E.; Girgis, S.; Gokbulut, G.; Gurpinar, E.; Hos, I.; Kangal, E. E.; Kayis Topaksu, A.; Onengut, G.; Ozdemir, K.; Ozturk, S.; Polatoz, A.; Sogut, K.; Sunar Cerci, D.; Tali, B.; Topakli, H.; Vergili, M.; Akin, I. V.; Aliev, T.; Bilin, B.; Bilmis, S.; Deniz, M.; Gamsizkan, H.; Guler, A. M.; Karapinar, G.; Ocalan, K.; Ozpineci, A.; Serin, M.; Sever, R.; Surat, U. E.; Yalvac, M.; Zeyrek, M.; Gülmez, E.; Isildak, B.; Kaya, M.; Kaya, O.; Ozkorucuklu, S.; Bahtiyar, H.; Barlas, E.; Cankocak, K.; Günaydin, Y. O.; Vardarlı, F. I.; Yücel, M.; Levchuk, L.; Sorokin, P.; Brooke, J. J.; Clement, E.; Cussans, D.; Flacher, H.; Frazier, R.; Goldstein, J.; Grimes, M.; Heath, G. P.; Heath, H. F.; Jacob, J.; Kreczko, L.; Lucas, C.; Meng, Z.; Newbold, D. M.; Paramesvaran, S.; Poll, A.; Senkin, S.; Smith, V. J.; Williams, T.; Bell, K. W.; Belyaev, A.; Brew, C.; Brown, R. M.; Cockerill, D. J. A.; Coughlan, J. A.; Harder, K.; Harper, S.; Ilic, J.; Olaiya, E.; Petyt, D.; Shepherd-Themistocleous, C. H.; Thea, A.; Tomalin, I. R.; Womersley, W. J.; Worm, S. D.; Baber, M.; Bainbridge, R.; Buchmuller, O.; Burton, D.; Colling, D.; Cripps, N.; Cutajar, M.; Dauncey, P.; Davies, G.; Della Negra, M.; Dunne, P.; Ferguson, W.; Fulcher, J.; Futyan, D.; Gilbert, A.; Guneratne Bryer, A.; Hall, G.; Hatherell, Z.; Hays, J.; Iles, G.; Jarvis, M.; Karapostoli, G.; Kenzie, M.; Lane, R.; Lucas, R.; Lyons, L.; Magnan, A.-M.; Marrouche, J.; Mathias, B.; Nandi, R.; Nash, J.; Nikitenko, A.; Pela, J.; Pesaresi, M.; Petridis, K.; Pioppi, M.; Raymond, D. M.; Rogerson, S.; Rose, A.; Seez, C.; Sharp, P.; Sparrow, A.; Tapper, A.; Vazquez Acosta, M.; Virdee, T.; Wakefield, S.; Wardle, N.; Cole, J. E.; Hobson, P. R.; Khan, A.; Kyberd, P.; Leggat, D.; Leslie, D.; Martin, W.; Reid, I. D.; Symonds, P.; Teodorescu, L.; Turner, M.; Dittmann, J.; Hatakeyama, K.; Kasmi, A.; Liu, H.; Scarborough, T.; Charaf, O.; Cooper, S. I.; Henderson, C.; Rumerio, P.; Avetisyan, A.; Bose, T.; Fantasia, C.; Heister, A.; Lawson, P.; Lazic, D.; Richardson, C.; Rohlf, J.; Sperka, D.; St. John, J.; Sulak, L.; Alimena, J.; Bhattacharya, S.; Christopher, G.; Cutts, D.; Demiragli, Z.; Ferapontov, A.; Garabedian, A.; Heintz, U.; Jabeen, S.; Kukartsev, G.; Laird, E.; Landsberg, G.; Luk, M.; Narain, M.; Segala, M.; Sinthuprasith, T.; Speer, T.; Swanson, J.; Breedon, R.; Breto, G.; Calderon De La Barca Sanchez, M.; Chauhan, S.; Chertok, M.; Conway, J.; Conway, R.; Cox, P. T.; Erbacher, R.; Gardner, M.; Ko, W.; Kopecky, A.; Lander, R.; Miceli, T.; Mulhearn, M.; Pellett, D.; Pilot, J.; Ricci-Tam, F.; Rutherford, B.; Searle, M.; Shalhout, S.; Smith, J.; Squires, M.; Tripathi, M.; Wilbur, S.; Yohay, R.; Andreev, V.; Cline, D.; Cousins, R.; Erhan, S.; Everaerts, P.; Farrell, C.; Felcini, M.; Hauser, J.; Ignatenko, M.; Jarvis, C.; Rakness, G.; Takasugi, E.; Valuev, V.; Weber, M.; Babb, J.; Clare, R.; Ellison, J.; Gary, J. W.; Hanson, G.; Heilman, J.; Jandir, P.; Lacroix, F.; Liu, H.; Long, O. R.; Luthra, A.; Malberti, M.; Nguyen, H.; Shrinivas, A.; Sturdy, J.; Sumowidagdo, S.; Wimpenny, S.; Andrews, W.; Branson, J. G.; Cerati, G. B.; Cittolin, S.; D'Agnolo, R. T.; Evans, D.; Holzner, A.; Kelley, R.; Kovalskyi, D.; Lebourgeois, M.; Letts, J.; Macneill, I.; Padhi, S.; Palmer, C.; Pieri, M.; Sani, M.; Sharma, V.; Simon, S.; Sudano, E.; Tadel, M.; Tu, Y.; Vartak, A.; Wasserbaech, S.; Würthwein, F.; Yagil, A.; Yoo, J.; Barge, D.; Bradmiller-Feld, J.; Campagnari, C.; Danielson, T.; Dishaw, A.; Flowers, K.; Franco Sevilla, M.; Geffert, P.; George, C.; Golf, F.; Incandela, J.; Justus, C.; Magaña Villalba, R.; Mccoll, N.; Pavlunin, V.; Richman, J.; Rossin, R.; Stuart, D.; To, W.; West, C.; Apresyan, A.; Bornheim, A.; Bunn, J.; Chen, Y.; Di Marco, E.; Duarte, J.; Kcira, D.; Mott, A.; Newman, H. B.; Pena, C.; Rogan, C.; Spiropulu, M.; Timciuc, V.; Wilkinson, R.; Xie, S.; Zhu, R. Y.; Azzolini, V.; Calamba, A.; Carroll, R.; Ferguson, T.; Iiyama, Y.; Jang, D. W.; Paulini, M.; Russ, J.; Vogel, H.; Vorobiev, I.; Cumalat, J. P.; Drell, B. R.; Ford, W. T.; Gaz, A.; Luiggi Lopez, E.; Nauenberg, U.; Smith, J. G.; Stenson, K.; Ulmer, K. A.; Wagner, S. R.; Alexander, J.; Chatterjee, A.; Chu, J.; Eggert, N.; Gibbons, L. K.; Hopkins, W.; Khukhunaishvili, A.; Kreis, B.; Mirman, N.; Nicolas Kaufman, G.; Patterson, J. R.; Ryd, A.; Salvati, E.; Sun, W.; Teo, W. D.; Thom, J.; Thompson, J.; Tucker, J.; Weng, Y.; Winstrom, L.; Wittich, P.; Winn, D.; Abdullin, S.; Albrow, M.; Anderson, J.; Apollinari, G.; Bauerdick, L. A. T.; Beretvas, A.; Berryhill, J.; Bhat, P. C.; Burkett, K.; Butler, J. N.; Chetluru, V.; Cheung, H. W. K.; Chlebana, F.; Cihangir, S.; Elvira, V. D.; Fisk, I.; Freeman, J.; Gao, Y.; Gottschalk, E.; Gray, L.; Green, D.; Grünendahl, S.; Gutsche, O.; Hanlon, J.; Hare, D.; Harris, R. M.; Hirschauer, J.; Hooberman, B.; Jindariani, S.; Johnson, M.; Joshi, U.; Kaadze, K.; Klima, B.; Kwan, S.; Linacre, J.; Lincoln, D.; Lipton, R.; Liu, T.; Lykken, J.; Maeshima, K.; Marraffino, J. M.; Martinez Outschoorn, V. I.; Maruyama, S.; Mason, D.; McBride, P.; Mishra, K.; Mrenna, S.; Musienko, Y.; Nahn, S.; Newman-Holmes, C.; O'Dell, V.; Prokofyev, O.; Ratnikova, N.; Sexton-Kennedy, E.; Sharma, S.; Soha, A.; Spalding, W. J.; Spiegel, L.; Taylor, L.; Tkaczyk, S.; Tran, N. V.; Uplegger, L.; Vaandering, E. W.; Vidal, R.; Whitbeck, A.; Whitmore, J.; Wu, W.; Yang, F.; Yun, J. C.; Acosta, D.; Avery, P.; Bourilkov, D.; Cheng, T.; Das, S.; De Gruttola, M.; Di Giovanni, G. P.; Dobur, D.; Field, R. D.; Fisher, M.; Fu, Y.; Furic, I. K.; Hugon, J.; Kim, B.; Konigsberg, J.; Korytov, A.; Kropivnitskaya, A.; Kypreos, T.; Low, J. F.; Matchev, K.; Milenovic, P.; Mitselmakher, G.; Muniz, L.; Rinkevicius, A.; Shchutska, L.; Skhirtladze, N.; Snowball, M.; Yelton, J.; Zakaria, M.; Gaultney, V.; Hewamanage, S.; Linn, S.; Markowitz, P.; Martinez, G.; Rodriguez, J. L.; Adams, T.; Askew, A.; Bochenek, J.; Chen, J.; Diamond, B.; Haas, J.; Hagopian, S.; Hagopian, V.; Johnson, K. F.; Prosper, H.; Veeraraghavan, V.; Weinberg, M.; Baarmand, M. M.; Dorney, B.; Hohlmann, M.; Kalakhety, H.; Yumiceva, F.; Adams, M. R.; Apanasevich, L.; Bazterra, V. E.; Betts, R. R.; Bucinskaite, I.; Cavanaugh, R.; Evdokimov, O.; Gauthier, L.; Gerber, C. E.; Hofman, D. J.; Khalatyan, S.; Kurt, P.; Moon, D. H.; O'Brien, C.; Silkworth, C.; Turner, P.; Varelas, N.; Akgun, U.; Albayrak, E. A.; Bilki, B.; Clarida, W.; Dilsiz, K.; Duru, F.; Haytmyradov, M.; Merlo, J.-P.; Mermerkaya, H.; Mestvirishvili, A.; Moeller, A.; Nachtman, J.; Ogul, H.; Onel, Y.; Ozok, F.; Penzo, A.; Rahmat, R.; Sen, S.; Tan, P.; Tiras, E.; Wetzel, J.; Yetkin, T.; Yi, K.; Barnett, B. A.; Blumenfeld, B.; Bolognesi, S.; Fehling, D.; Gritsan, A. V.; Maksimovic, P.; Martin, C.; Swartz, M.; Baringer, P.; Bean, A.; Benelli, G.; Gray, J.; Kenny, R. P.; Murray, M.; Noonan, D.; Sanders, S.; Sekaric, J.; Stringer, R.; Wang, Q.; Wood, J. S.; Barfuss, A. F.; Chakaberia, I.; Ivanov, A.; Khalil, S.; Makouski, M.; Maravin, Y.; Saini, L. K.; Shrestha, S.; Svintradze, I.; Gronberg, J.; Lange, D.; Rebassoo, F.; Wright, D.; Baden, A.; Calvert, B.; Eno, S. C.; Gomez, J. A.; Hadley, N. J.; Kellogg, R. G.; Kolberg, T.; Lu, Y.; Marionneau, M.; Mignerey, A. C.; Pedro, K.; Skuja, A.; Temple, J.; Tonjes, M. B.; Tonwar, S. C.; Apyan, A.; Barbieri, R.; Bauer, G.; Busza, W.; Cali, I. A.; Chan, M.; Di Matteo, L.; Dutta, V.; Gomez Ceballos, G.; Goncharov, M.; Gulhan, D.; Klute, M.; Lai, Y. S.; Lee, Y.-J.; Levin, A.; Luckey, P. D.; Ma, T.; Paus, C.; Ralph, D.; Roland, C.; Roland, G.; Stephans, G. S. F.; Stöckli, F.; Sumorok, K.; Velicanu, D.; Veverka, J.; Wyslouch, B.; Yang, M.; Yoon, A. S.; Zanetti, M.; Zhukova, V.; Dahmes, B.; De Benedetti, A.; Gude, A.; Kao, S. C.; Klapoetke, K.; Kubota, Y.; Mans, J.; Pastika, N.; Rusack, R.; Singovsky, A.; Tambe, N.; Turkewitz, J.; Acosta, J. G.; Cremaldi, L. M.; Kroeger, R.; Oliveros, S.; Perera, L.; Sanders, D. A.; Summers, D.; Avdeeva, E.; Bloom, K.; Bose, S.; Claes, D. R.; Dominguez, A.; Gonzalez Suarez, R.; Keller, J.; Knowlton, D.; Kravchenko, I.; Lazo-Flores, J.; Malik, S.; Meier, F.; Snow, G. R.; Dolen, J.; Godshalk, A.; Iashvili, I.; Jain, S.; Kharchilava, A.; Kumar, A.; Rappoccio, S.; Alverson, G.; Barberis, E.; Baumgartel, D.; Chasco, M.; Haley, J.; Massironi, A.; Nash, D.; Orimoto, T.; Trocino, D.; Wood, D.; Zhang, J.; Anastassov, A.; Hahn, K. A.; Kubik, A.; Lusito, L.; Mucia, N.; Odell, N.; Pollack, B.; Pozdnyakov, A.; Schmitt, M.; Stoynev, S.; Sung, K.; Velasco, M.; Won, S.; Berry, D.; Brinkerhoff, A.; Chan, K. M.; Drozdetskiy, A.; Hildreth, M.; Jessop, C.; Karmgard, D. J.; Kellams, N.; Kolb, J.; Lannon, K.; Luo, W.; Lynch, S.; Marinelli, N.; Morse, D. M.; Pearson, T.; Planer, M.; Ruchti, R.; Slaunwhite, J.; Valls, N.; Wayne, M.; Wolf, M.; Woodard, A.; Antonelli, L.; Bylsma, B.; Durkin, L. S.; Flowers, S.; Hill, C.; Hughes, R.; Kotov, K.; Ling, T. Y.; Puigh, D.; Rodenburg, M.; Smith, G.; Vuosalo, C.; Winer, B. L.; Wolfe, H.; Wulsin, H. W.; Berry, E.; Elmer, P.; Halyo, V.; Hebda, P.; Hunt, A.; Jindal, P.; Koay, S. A.; Lujan, P.; Marlow, D.; Medvedeva, T.; Mooney, M.; Olsen, J.; Piroué, P.; Quan, X.; Raval, A.; Saka, H.; Stickland, D.; Tully, C.; Werner, J. S.; Zenz, S. C.; Zuranski, A.; Brownson, E.; Lopez, A.; Mendez, H.; Ramirez Vargas, J. E.; Alagoz, E.; Barnes, V. E.; Benedetti, D.; Bolla, G.; Bortoletto, D.; De Mattia, M.; Everett, A.; Hu, Z.; Jha, M. K.; Jones, M.; Jung, K.; Kress, M.; Leonardo, N.; Lopes Pegna, D.; Maroussov, V.; Merkel, P.; Miller, D. H.; Neumeister, N.; Radburn-Smith, B. C.; Shipsey, I.; Silvers, D.; Svyatkovskiy, A.; Wang, F.; Xie, W.; Xu, L.; Yoo, H. D.; Zablocki, J.; Zheng, Y.; Parashar, N.; Stupak, J.; Adair, A.; Akgun, B.; Ecklund, K. M.; Geurts, F. J. M.; Li, W.; Michlin, B.; Padley, B. P.; Redjimi, R.; Roberts, J.; Zabel, J.; Betchart, B.; Bodek, A.; Covarelli, R.; de Barbaro, P.; Demina, R.; Eshaq, Y.; Ferbel, T.; Garcia-Bellido, A.; Goldenzweig, P.; Han, J.; Harel, A.; Miner, D. C.; Petrillo, G.; Vishnevskiy, D.; Zielinski, M.; Bhatti, A.; Ciesielski, R.; Demortier, L.; Goulianos, K.; Lungu, G.; Malik, S.; Mesropian, C.; Arora, S.; Barker, A.; Chou, J. P.; Contreras-Campana, C.; Contreras-Campana, E.; Duggan, D.; Ferencek, D.; Gershtein, Y.; Gray, R.; Halkiadakis, E.; Hidas, D.; Lath, A.; Panwalkar, S.; Park, M.; Patel, R.; Rekovic, V.; Robles, J.; Salur, S.; Schnetzer, S.; Seitz, C.; Somalwar, S.; Stone, R.; Thomas, S.; Thomassen, P.; Walker, M.; Rose, K.; Spanier, S.; Yang, Z. C.; York, A.; Bouhali, O.; Eusebi, R.; Flanagan, W.; Gilmore, J.; Kamon, T.; Khotilovich, V.; Krutelyov, V.; Montalvo, R.; Osipenkov, I.; Pakhotin, Y.; Perloff, A.; Roe, J.; Rose, A.; Safonov, A.; Sakuma, T.; Suarez, I.; Tatarinov, A.; Toback, D.; Akchurin, N.; Cowden, C.; Damgov, J.; Dragoiu, C.; Dudero, P. R.; Faulkner, J.; Kovitanggoon, K.; Kunori, S.; Lee, S. W.; Libeiro, T.; Volobouev, I.; Appelt, E.; Delannoy, A. G.; Greene, S.; Gurrola, A.; Johns, W.; Maguire, C.; Mao, Y.; Melo, A.; Sharma, M.; Sheldon, P.; Snook, B.; Tuo, S.; Velkovska, J.; Arenton, M. W.; Boutle, S.; Cox, B.; Francis, B.; Goodell, J.; Hirosky, R.; Ledovskoy, A.; Li, H.; Lin, C.; Neu, C.; Wood, J.; Gollapinni, S.; Harr, R.; Karchin, P. E.; Kottachchi Kankanamge Don, C.; Lamichhane, P.; Belknap, D. A.; Borrello, L.; Carlsmith, D.; Cepeda, M.; Dasu, S.; Duric, S.; Friis, E.; Grothe, M.; Hall-Wilton, R.; Herndon, M.; Hervé, A.; Klabbers, P.; Klukas, J.; Lanaro, A.; Lazaridis, C.; Levine, A.; Loveless, R.; Mohapatra, A.; Ojalvo, I.; Perry, T.; Pierro, G. A.; Polese, G.; Ross, I.; Sarangi, T.; Savin, A.; Smith, W. H.; Woods, N.; CMS Collaboration

2014-08-01

A search for WVγ triple vector boson production is presented based on events containing a W boson decaying to a muon or an electron and a neutrino, a second V (W or Z) boson, and a photon. The data correspond to an integrated luminosity of 19.3 fb-1 collected in 2012 with the CMS detector at the LHC in pp collisions at √s =8 TeV. An upper limit of 311 fb on the cross section for the WVγ production process is obtained at 95% confidence level for photons with a transverse energy above 30 GeV and with an absolute value of pseudorapidity of less than 1.44. This limit is approximately a factor of 3.4 larger than the standard model predictions that are based on next-to-leading order QCD calculations. Since no evidence of anomalous WWγγ or WWZγ quartic gauge boson couplings is found, this paper presents the first experimental limits on the dimension-eight parameter fT,0 and the CP-conserving WWZγ parameters κ0W and κCW. Limits are also obtained for the WWγγ parameters a0W and aCW.

Population Control of Self-Replicating Systems: Option C

NASA Technical Reports Server (NTRS)

Mccord, R. L.

1983-01-01

From the conception and development of the theory of self-replicating automata by John von Neumann, others have expanded on his theories. In 1980, Georg von Tiesenhausen and Wesley A. Darbro developed a report which is a "first' in presenting the theories in a conceptualized engineering setting. In that report several options involving self-replicating systems are presented. One of the options allows each primary to generate n replicas, one in each sequential time frame after its own generation. Each replica is limited to a maximum of m ancestors. This study involves determining the state vector of the replicas in an efficient manner. The problem is cast in matrix notation, where F = fij is a non-diagonalizable matrix. Any element fij represents the number of elements of type j = (c,d) in time frame k+1 generated from type i = (a,b) in time frame k. It is then shown that the state vector is: bar F(k)=bar F (non-zero) X F sub K = bar F (non-zero) xmx J sub kx m sub-1 where J is a matrix in Jordan form having the same eigenvalues as F. M is a matrix composed of the eigenvectors and the generalized eigenvectors of F.

Reductive Elimination Leading to C-C Bond Formation in Gold(III) Complexes: A Mechanistic and Computational Study.

PubMed

Rocchigiani, Luca; Fernandez-Cestau, Julio; Budzelaar, Peter H M; Bochmann, Manfred

2018-06-21

The factors affecting the rates of reductive C-C cross-coupling reactions in gold(III) aryls were studied by using complexes that allow easy access to a series of electronically modified aryl ligands, as well as to gold methyl and vinyl complexes, by using the pincer compounds [(C^N^C)AuR] (R=C 6 F 5 , CH=CMe 2 , Me and p-C 6 H 4 X, where X=OMe, F, H, tBu, Cl, CF 3 , or NO 2 ) as starting materials (C^N^C=2,6-(4'-tBuC 6 H 3 ) 2 pyridine dianion). Protodeauration followed by addition of one equivalent SMe 2 leads to the quantitative generation of the thioether complexes [(C^N-CH)AuR(SMe 2 )] + . Upon addition of a second SMe 2 pyridine is displaced, which triggers the reductive aryl-R elimination. The rates for these cross-couplings increase in the sequence k(vinyl)>k(aryl)≫k(C 6 F 5 )>k(Me). Vinyl-aryl coupling is particularly fast, 1.15×10 -3  L mol -1  s -1 at 221 K, whereas both C 6 F 5 and Me couplings encountered higher barriers for the C-C bond forming step. The use of P(p-tol) 3 in place of SMe 2 greatly accelerates the C-C couplings. Computational modelling shows that in the C^N-bonded compounds displacement of N by a donor L is required before the aryl ligands can adopt a conformation suitable for C-C bond formation, so that elimination takes place from a four-coordinate intermediate. The C-C bond formation is the rate-limiting step. In the non-chelating case, reductive C(sp 2 )-C(sp 2 ) elimination from three-coordinate ions [(Ar 1 )(Ar 2 )AuL] + is almost barrier-free, particularly if L=phosphine. © 2018 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.

Optimizing Prevention of HIV and Unplanned Pregnancy in Discordant African Couples.

PubMed

Wall, Kristin M; Kilembe, William; Vwalika, Bellington; Haddad, Lisa B; Khu, Naw Htee; Brill, Ilene; Onwubiko, Udodirim; Chomba, Elwyn; Tichacek, Amanda; Allen, Susan

2017-08-01

Dual method use, which combines condoms with a more effective modern contraceptive to optimize prevention of HIV and unplanned pregnancy, is underutilized in high-risk heterosexual couples. Heterosexual HIV-discordant Zambian couples were enrolled from couples' voluntary HIV counseling and testing services into an open cohort with 3-monthly follow-up (1994-2012). Relative to dual method use, defined as consistent condom use plus modern contraception, we examine predictors of (1) condom-only use (suboptimal pregnancy prevention) or (2) modern contraceptive use with inconsistent condom use (effective pregnancy prevention and suboptimal HIV prevention). Among 3,049 couples, dual method use occurred in 28% of intervals in M+F- and 23% in M-F+, p < 0.01; condom-only use in 56% in M+F- and 61% in M-F+, p < 0.01; and modern contraceptive use with inconsistent condom use in 16% regardless of serostatus. Predictors (p < 0.05) of condom-only use included the man being HIV+ (adjusted hazard ratio, aHR = 1.15); baseline oral contraceptive pill (aHR = 0.76), injectable (aHR = 0.48), or implant (aHR = 0.60) use; woman's age (aHR = 1.04 per 5 years) and lifetime number of sex partners (aHR = 1.01); postpartum periods (aHR = 1.25); and HIV stage of the index partner III/IV versus I (aHR = 1.10). Predictors (p < 0.05) of modern contraceptive use with inconsistent condom use included woman's age (aHR = 0.94 per 5 years) and HIV+ male circumcision (aHR = 1.51), while time-varying implant use was associated with more consistent condom use (aHR = 0.80). Three-quarters of follow-up intervals did not include dual method use. This highlights the need for counseling to reduce unintended pregnancy and HIV transmission and enable safer conception.

Observation of EIA in closed and open caesium atomic system

NASA Astrophysics Data System (ADS)

Zhao, Jian-Ming; Zhao, Yan-Ting; Huang, Tao; Xiao, Lian-Tuan; Jia, Suo-Tang

2005-04-01

We present an experimental study on electromagnetically induced absorption (EIA) in the closed transition of a degenerate two-level Cs atomic system. The coupling and probe lasers coupled with the transition 6S1/2F=4 → 6P3/2F'=5 of caesium atom. The signal of EIA was obtained and the frequency detuning and intensity effect of the pumping laser were experimentally investigated. The EIA signal in 6S1/2 F=4 → 6P3/2 F'=4 and 6S1/2 F=4 → 6P3/2 F'=3 open transitions was also obtained. As the repumping laser couples with the transition of 6S1/2 F=3 → 6P3/2 F'=4, the EIA signal is increased due to the hyperfine optical pumping.

Fast and slowly evolving vector solitons in mode-locked fibre lasers.

PubMed

Sergeyev, Sergey V

2014-10-28

We report on a new vector model of an erbium-doped fibre laser mode locked with carbon nanotubes. This model goes beyond the limitations of the previously used models based on either coupled nonlinear Schrödinger or Ginzburg-Landau equations. Unlike the previous models, it accounts for the vector nature of the interaction between an optical field and an erbium-doped active medium, slow relaxation dynamics of erbium ions, linear birefringence in a fibre, linear and circular birefringence of a laser cavity caused by in-cavity polarization controller and light-induced anisotropy caused by elliptically polarized pump field. Interplay of aforementioned factors changes coherent coupling of two polarization modes at a long time scale and so results in a new family of vector solitons (VSs) with fast and slowly evolving states of polarization. The observed VSs can be of interest in secure communications, trapping and manipulation of atoms and nanoparticles, control of magnetization in data storage devices and many other areas. © 2014 The Author(s) Published by the Royal Society. All rights reserved.

The nonlinear chemo-mechanic coupled dynamics of the F 1 -ATPase molecular motor.

PubMed

Xu, Lizhong; Liu, Fang

2012-03-01

The ATP synthase consists of two opposing rotary motors, F0 and F1, coupled to each other. When the F1 motor is not coupled to the F0 motor, it can work in the direction hydrolyzing ATP, as a nanomotor called F1-ATPase. It has been reported that the stiffness of the protein varies nonlinearly with increasing load. The nonlinearity has an important effect on the rotating rate of the F1-ATPase. Here, considering the nonlinearity of the γ shaft stiffness for the F1-ATPase, a nonlinear chemo-mechanical coupled dynamic model of F1 motor is proposed. Nonlinear vibration frequencies of the γ shaft and their changes along with the system parameters are investigated. The nonlinear stochastic response of the elastic γ shaft to thermal excitation is analyzed. The results show that the stiffness nonlinearity of the γ shaft causes an increase of the vibration frequency for the F1 motor, which increases the motor's rotation rate. When the concentration of ATP is relatively high and the load torque is small, the effects of the stiffness nonlinearity on the rotating rates of the F1 motor are obvious and should be considered. These results are useful for improving calculation of the rotating rate for the F1 motor and provide insight about the stochastic wave mechanics of F1-ATPase.

Experimental transmission of Powassan virus (Flaviviridae) by Ixodes scapularis ticks (Acari:Ixodidae).

PubMed

Costero, A; Grayson, M A

1996-11-01

Transmission experiments were performed with Ixodes scapularis ticks from an uninfected laboratory colony. Immature and adult ticks were exposed to Powassan (POW) viremic hamsters and rabbits, respectively. Oral infection rates for engorged larvae, nymphs and females fed on POW-infected hosts were 10%, 40%, and 57%, respectively. Transstadial transmission rates for nymphs exposed to POW virus as larvae, adults exposed as larvae, and adults exposed as nymphs, were 9.5%, 10%, and 54%, respectively. Evidence of transovarial transmission occurred when two uninfected hamsters, exposed to F2 larvae and nymphs originally exposed to POW virus in the F1 nymphal stage, seroconverted to POW virus with hemagglutination inhibition titers of 80 and 5,120, respectively; the transovarial transmission rate was 16.6%. All developmental stages were able to transmit virus orally to uninfected hosts regardless of when the ticks were originally exposed to the virus. These results suggest that I. scapularis is a competent vector of POW virus under experimental conditions.

Decay constants and radiative decays of heavy mesons in light-front quark model

DOE Office of Scientific and Technical Information (OSTI.GOV)

Choi, Ho-Meoyng

2007-04-01

We investigate the magnetic dipole decays V{yields}P{gamma} of various heavy-flavored mesons such as (D,D*,D{sub s},D{sub s}*,{eta}{sub c},J/{psi}) and (B,B*,B{sub s},B{sub s}*,{eta}{sub b},{upsilon}) using the light-front quark model constrained by the variational principle for the QCD-motivated effective Hamiltonian. The momentum dependent form factors F{sub VP}(q{sup 2}) for V{yields}P{gamma}* decays are obtained in the q{sup +}=0 frame and then analytically continued to the timelike region by changing q{sub perpendicular} to iq{sub perpendicular} in the form factors. The coupling constant g{sub VP{gamma}} for real photon case is then obtained in the limit as q{sup 2}{yields}0, i.e. g{sub VP{gamma}}=F{sub VP}(q{sup 2}=0). The weak decaymore » constants of heavy pseudoscalar and vector mesons are also calculated. Our numerical results for the decay constants and radiative decay widths for the heavy-flavored mesons are overall in good agreement with the available experimental data as well as other theoretical model calculations.« less

Essential arginine in subunit a and aspartate in subunit c of FoF1 ATP synthase: effect of repositioning within helix 4 of subunit a and helix 2 of subunit c.

PubMed

Langemeyer, Lars; Engelbrecht, Siegfried

2007-07-01

FoF1 ATP synthase couples proton flow through the integral membrane portion Fo (ab2c10) to ATP-synthesis in the extrinsic F1-part ((alphabeta)3gammadeltaepsilon) (Escherichia coli nomenclature and stoichiometry). Coupling occurs by mechanical rotation of subunits c10gammaepsilon relative to (alphabeta)3deltaab2. Two residues were found to be essential for proton flow through ab2c10, namely Arg210 in subunit a (aR210) and Asp61 in subunits c (cD61). Their deletion abolishes proton flow, but "horizontal" repositioning, by anchoring them in adjacent transmembrane helices, restores function. Here, we investigated the effects of "vertical" repositioning aR210, cD61, or both by one helical turn towards the N- or C-termini of their original helices. Other than in the horizontal the vertical displacement changes the positions of the side chains within the depth of the membrane. Mutant aR210A/aN214R appeared to be short-circuited in that it supported proton conduction only through EF1-depleted EFo, but not in EFoEF1, nor ATP-driven proton pumping. Mutant cD61N/cM65D grew on succinate, retained the ability to synthesize ATP and supported passive proton conduction but apparently not ATP hydrolysis-driven proton pumping.

Single vector platform vaccine protects against lethal respiratory challenge with Tier 1 select agents of anthrax, plague, and tularemia.

PubMed

Jia, Qingmei; Bowen, Richard; Dillon, Barbara Jane; Masleša-Galić, Saša; Chang, Brennan T; Kaidi, Austin C; Horwitz, Marcus A

2018-05-03

Bacillus anthracis, Yersinia pestis, and Francisella tularensis are the causative agents of Tier 1 Select Agents anthrax, plague, and tularemia, respectively. Currently, there are no licensed vaccines against plague and tularemia and the licensed anthrax vaccine is suboptimal. Here we report F. tularensis LVS ΔcapB (Live Vaccine Strain with a deletion in capB)- and attenuated multi-deletional Listeria monocytogenes (Lm)-vectored vaccines against all three aforementioned pathogens. We show that LVS ΔcapB- and Lm-vectored vaccines express recombinant B. anthracis, Y. pestis, and F. tularensis immunoprotective antigens in broth and in macrophage-like cells and are non-toxic in mice. Homologous priming-boosting with the LVS ΔcapB-vectored vaccines induces potent antigen-specific humoral and T-cell-mediated immune responses and potent protective immunity against lethal respiratory challenge with all three pathogens. Protection against anthrax was far superior to that obtained with the licensed AVA vaccine and protection against tularemia was comparable to or greater than that obtained with the toxic and unlicensed LVS vaccine. Heterologous priming-boosting with LVS ΔcapB- and Lm-vectored B. anthracis and Y. pestis vaccines also induced potent protective immunity against lethal respiratory challenge with B. anthracis and Y. pestis. The single vaccine platform, especially the LVS ΔcapB-vectored vaccine platform, can be extended readily to other pathogens.

Spatial vector soliton and its collisions in isotropic self-defocusing Kerr media.

PubMed

Radhakrishnan, R; Aravinthan, K

2007-06-01

A fairly general form of the two-component (dark-dark) vector one-soliton solution of the integrable coupled nonlinear Schrödinger equation (Manakov model) with self-defocusing nonlinearity is obtained by using the Hirota method. It couples two dark components with the same envelope width, envelope speed, and envelope trough location using two complex arbitrary parameters not only in the envelope amplitude but also in the complex modulation. Although it has the freedom to change its pulse width without affecting its speed, it can also tune its grayness (depth of the pulse relative to background) without disturbing the envelope width and speed. The variations in peak power against the depth of localization of two dark components are investigated with and without a parametric restriction. The collision between many dark-dark vector solitons has also been studied by constructing a multisoliton solution with more free parameters.

Alterations to the relativistic Love-Franey model and their application to inelastic scattering

DOE Office of Scientific and Technical Information (OSTI.GOV)

Zeile, J.R.

The fictitious axial-vector and tensor mesons for the real part of the relativistic Love-Franey interaction are removed. In an attempt to make up for this loss, derivative couplings are used for the {pi} and {rho} mesons. Such derivative couplings require the introduction of axial-vector and tensor contact term corrections. Meson parameters are then fit to free nucleon-nucleon scattering data. The resulting fits are comparable to those of the relativistic Love-Franey model provided that the contact term corrections are included and the fits are weighted over the physically significant quantity of twice the tensor minus the axial-vector Lorentz invariants. Failure tomore » include contact term corrections leads to poor fits at higher energies. The off-shell behavior of this model is then examined by looking at several applications from inelastic proton-nucleus scattering.« less

Holographic P -wave superconductors in 1 +1 dimensions

NASA Astrophysics Data System (ADS)

Alkac, Gokhan; Chakrabortty, Shankhadeep; Chaturvedi, Pankaj

2017-10-01

We study (1 +1 )-dimensional P -wave holographic superconductors described by three- dimensional Einstein-Maxwell gravity coupled to a massive complex vector field in the context of AdS3/CFT2 correspondence. In the probe limit, where the backreaction of matter fields is neglected, we show that there is a formation of a vector hair around the black hole below a certain critical temperature. In the dual strongly coupled (1 +1 )-dimensional boundary theory, this holographically corresponds to the formation of a charged vector condensate which breaks spontaneously both the U (1 ) and S O (1 ,1 ) symmetries. We numerically compute both the free energy and the ac conductivity for the superconducting phase of the boundary field theory. Our numerical computations clearly establish that the superconducting phase of the boundary theory is favorable to the normal phase, and the presence of a magnetic moment term in the dual bulk theory effects the conductivity in the boundary field theory.

Lymnaea schirazensis, an Overlooked Snail Distorting Fascioliasis Data: Genotype, Phenotype, Ecology, Worldwide Spread, Susceptibility, Applicability

PubMed Central

Bargues, María Dolores; Artigas, Patricio; Khoubbane, Messaoud; Flores, Rosmary; Glöer, Peter; Rojas-García, Raúl; Ashrafi, Keyhan; Falkner, Gerhard; Mas-Coma, Santiago

2011-01-01

Background Lymnaeid snails transmit medical and veterinary important trematodiases, mainly fascioliasis. Vector specificity of fasciolid parasites defines disease distribution and characteristics. Different lymnaeid species appear linked to different transmission and epidemiological patterns. Pronounced susceptibility differences to absolute resistance have been described among lymnaeid populations. When assessing disease characteristics in different endemic areas, unexpected results were obtained in studies on lymnaeid susceptibility to Fasciola. We undertook studies to understand this disease transmission heterogeneity. Methodology/Principal Findings A ten-year study in Iran, Egypt, Spain, the Dominican Republic, Mexico, Venezuela, Ecuador and Peru, demonstrated that such heterogeneity is not due to susceptibility differences, but to a hitherto overlooked cryptic species, Lymnaea schirazensis, confused with the main vector Galba truncatula and/or other Galba/Fossaria vectors. Nuclear rDNA and mtDNA sequences and phylogenetic reconstruction highlighted an old evolutionary divergence from other Galba/Fossaria species, and a low intraspecific variability suggesting a recent spread from one geographical source. Morphometry, anatomy and egg cluster analyses allowed for phenotypic differentiation. Selfing, egg laying, and habitat characteristics indicated a migration capacity by passive transport. Studies showed that it is not a vector species (n = 8572 field collected, 20 populations): snail finding and penetration by F. hepatica miracidium occur but never lead to cercarial production (n = 338 experimentally infected). Conclusions/Significance This species has been distorting fasciolid specificity/susceptibility and fascioliasis geographical distribution data. Hence, a large body of literature on G. truncatula should be revised. Its existence has henceforth to be considered in research. Genetic data on livestock, archeology and history along the 10,000-year post-domestication period explain its wide spread from the Neolithic Fertile Crescent. It is an efficient biomarker for the follow-up of livestock movements, a crucial aspect in fascioliasis emergence. It offers an outstanding laboratory model for genetic studies on susceptibility/resistance in F. hepatica/lymnaeid interaction, a field of applied research with disease control perspectives. PMID:21980347

Decays of the vector glueball

NASA Astrophysics Data System (ADS)

Giacosa, Francesco; Sammet, Julia; Janowski, Stanislaus

2017-06-01

We calculate two- and three-body decays of the (lightest) vector glueball into (pseudo)scalar, (axial-)vector, as well as pseudovector and excited vector mesons in the framework of a model of QCD. While absolute values of widths cannot be predicted because the corresponding coupling constants are unknown, some interesting branching ratios can be evaluated by setting the mass of the yet hypothetical vector glueball to 3.8 GeV as predicted by quenched lattice QCD. We find that the decay mode ω π π should be one of the largest (both through the decay chain O →b1π →ω π π and through the direct coupling O →ω π π ). Similarly, the (direct and indirect) decay into π K K*(892 ) is sizable. Moreover, the decays into ρ π and K*(892 )K are, although subleading, possible and could play a role in explaining the ρ π puzzle of the charmonium state ψ (2 S ) thanks to a (small) mixing with the vector glueball. The vector glueball can be directly formed at the ongoing BESIII experiment as well as at the future PANDA experiment at the FAIR facility. If the width is sufficiently small (≲100 MeV ) it should not escape future detection. It should be stressed that the employed model is based on some inputs and simplifying assumptions: the value of glueball mass (at present, the quenched lattice value is used), the lack of mixing of the glueball with other quarkonium states, and the use of few interaction terms. It then represents a first step toward the identification of the main decay channels of the vector glueball, but shall be improved when corresponding experimental candidates and/or new lattice results will be available.

Toward (finally!) ruling out Z and Higgs mediated dark matter models

DOE Office of Scientific and Technical Information (OSTI.GOV)

Escudero, Miguel; Berlin, Asher; Hooper, Dan

2016-12-01

In recent years, direct detection, indirect detection, and collider experiments have placed increasingly stringent constraints on particle dark matter, exploring much of the parameter space associated with the WIMP paradigm. In this paper, we focus on the subset of WIMP models in which the dark matter annihilates in the early universe through couplings to either the Standard Model Z or the Standard Model Higgs boson. Considering fermionic, scalar, and vector dark matter candidates within a model-independent context, we find that the overwhelming majority of these dark matter candidates are already ruled out by existing experiments. In the case of Zmore » mediated dark matter, the only scenarios that are not currently excluded are those in which the dark matter is a fermion with an axial coupling and with a mass either within a few GeV of the Z resonance ( m {sub DM} ≅ m {sub Z} /2) or greater than 200 GeV, or with a vector coupling and with m {sub DM} > 6 TeV . Several Higgs mediated scenarios are currently viable if the mass of the dark matter is near the Higgs pole ( m {sub DM} ≅ m {sub H} /2). Otherwise, the only scenarios that are not excluded are those in which the dark matter is a scalar (vector) heavier than 400 GeV (1160 GeV) with a Higgs portal coupling, or a fermion with a pseudoscalar (CP violating) coupling to the Standard Model Higgs boson. With the exception of dark matter with a purely pseudoscalar coupling to the Higgs, it is anticipated that planned direct detection experiments will probe nearly the entire range of models considered in this study.« less

Toward (finally!) ruling out Z and Higgs mediated dark matter models

DOE PAGES

Escudero, Miguel; Fermi National Accelerator Lab.; Berlin, Asher; ...

2016-12-15

In recent years, direct detection, indirect detection, and collider experiments have placed increasingly stringent constraints on particle dark matter, exploring much of the parameter space associated with the WIMP paradigm. In this paper, we focus on the subset of WIMP models in which the dark matter annihilates in the early universe through couplings to either the Standard Model Z or the Standard Model Higgs boson. Considering fermionic, scalar, and vector dark matter candidates within a model-independent context, we find that the overwhelming majority of these dark matter candidates are already ruled out by existing experiments. In the case of Zmore » mediated dark matter, the only scenarios that are not currently excluded are those in which the dark matter is a fermion with an axial coupling and with a mass either within a few GeV of the Z resonance (m DM ≃ m Z/2) or greater than 200 GeV, or with a vector coupling and with m DM > 6 TeV . Several Higgs mediated scenarios are currently viable if the mass of the dark matter is near the Higgs pole (m DM ≃ m H/2). Otherwise, the only scenarios that are not excluded are those in which the dark matter is a scalar (vector) heavier than 400 GeV (1160 GeV) with a Higgs portal coupling, or a fermion with a pseudoscalar (CP violating) coupling to the Standard Model Higgs boson. Furthermore, with the exception of dark matter with a purely pseudoscalar coupling to the Higgs, it is anticipated that planned direct detection experiments will probe nearly the entire range of models considered in this study.« less

Toward (finally!) ruling out Z and Higgs mediated dark matter models

DOE Office of Scientific and Technical Information (OSTI.GOV)

Escudero, Miguel; Fermi National Accelerator Lab.; Berlin, Asher

In recent years, direct detection, indirect detection, and collider experiments have placed increasingly stringent constraints on particle dark matter, exploring much of the parameter space associated with the WIMP paradigm. In this paper, we focus on the subset of WIMP models in which the dark matter annihilates in the early universe through couplings to either the Standard Model Z or the Standard Model Higgs boson. Considering fermionic, scalar, and vector dark matter candidates within a model-independent context, we find that the overwhelming majority of these dark matter candidates are already ruled out by existing experiments. In the case of Zmore » mediated dark matter, the only scenarios that are not currently excluded are those in which the dark matter is a fermion with an axial coupling and with a mass either within a few GeV of the Z resonance (m DM ≃ m Z/2) or greater than 200 GeV, or with a vector coupling and with m DM > 6 TeV . Several Higgs mediated scenarios are currently viable if the mass of the dark matter is near the Higgs pole (m DM ≃ m H/2). Otherwise, the only scenarios that are not excluded are those in which the dark matter is a scalar (vector) heavier than 400 GeV (1160 GeV) with a Higgs portal coupling, or a fermion with a pseudoscalar (CP violating) coupling to the Standard Model Higgs boson. Furthermore, with the exception of dark matter with a purely pseudoscalar coupling to the Higgs, it is anticipated that planned direct detection experiments will probe nearly the entire range of models considered in this study.« less

DSP-based CSO cancellation technique for RoF transmission system implemented by using directly modulated laser.

PubMed

Kim, Byung Gon; Bae, Sung Hyun; Kim, Hoon; Chung, Yun C

2017-05-29

We propose and demonstrate a simple composite second-order (CSO) cancellation technique based on the digital signal processing (DSP) for the radio-over-fiber (RoF) transmission system implemented by using directly modulated lasers (DMLs). When the RoF transmission system is implemented by using DMLs, its performance could be limited by the CSO distortions caused by the interplay between the DML's chirp and fiber's chromatic dispersion. We present the theoretical analysis of these nonlinear distortions and show that they can be suppressed at the receiver by using a simple DSP. To verify the effectiveness of the proposed technique, we demonstrate the transmission of twenty-four 100-MHz filtered orthogonal frequency-division multiplexing (f-OFDM) signals in 64 quadrature amplitude modulation (QAM) format over 20 km of the standard single-mode fiber (SSMF). The results show that, by using the proposed technique, we can suppress the CSO distortion components by >10 dB and achieve the error-vector magnitude performance better than 6% even after the 20-km long SSMF transmission.