Population trapping in the excited states using vacuum-induced coherence and adiabatic process

NASA Astrophysics Data System (ADS)

Lal Kumawat, Babu; Kumar, Pardeep; Dasgupta, Shubhrangshu

2018-02-01

We theoretically investigate how population can be trapped in the closely spaced excited levels in presence of vacuum-induced coherence (VIC). We employ delayed pulses to transfer population from a meta-stable state to the excited states. Subsequently, spontaneous emission from these excited states builds coherence between them. This coherence can be probed by using chirping, which leads to the decoupling of the excited states from the ground state thereby ensuring population transfer via delayed pulses. Our results indicate that the existence of VIC leads to the generation of a mixed state in the excited state manifold, where trapping of the population occurs even in the presence of large decay. This trapping may be realized in molecular systems and can be interpreted as a sensitive probe of VIC. We present suitable numerical analysis to support our results.

Blood Meal Preference of Some Anopheline Mosquitoes in Command and Non-command Areas of Rajasthan, India.

PubMed

Swami, Kailash Kumar; Srivastava, Meera

2012-12-01

The present study was undertaken to compare the entomological situation by analyzing the blood meal of mosquitoes of canal irrigated and non-irrigated areas of Bikaner in order to explore scientific information on the vector biology and malaria burden profile and to plan proper strategies for malaria control and eradication. Adult mosquitoes were collected and the abdomen of the blood fed females were crushed on a filter paper for blood meal analysis and subjected to precipitin test. The blood meal analysis showed that Anopheles subpictus had a preference towards cattle blood, An. culicifacies and An. stephensi preferred human blood, while, An. annularis was noted to feed only on bovine blood. Although An. annularis, has been recently reported from the area, was found to feed exclusively on bovine blood, earlier reports suggest that this species is a vector of malaria and therefore preventive measures should be taken well in advance before this species gets established in the area.

Advanced Distributed Simulation Technology II (ADST-II) Dismounted Warrior Network Front End Analysis Experiments

DTIC Science & Technology

1997-12-19

Resource Consultants Inc. (RCI) Science Applications InternatT Corp (SAIC) Veda Inc. Virtual Space Devices (VSD) 1.1 Background The Land Warrior...network. The VICs included: • VIC Alpha - a fully immersive Dismounted Soldier System developed by Veda under a STRICOM applied research effort...consists of the Dismounted Soldier System (DSS), which is characterized as follows: • Developed by Veda under a STRICOM applied research effort

Soil Moisture Drought Monitoring and Forecasting Using Satellite and Climate Model Data over Southwestern China

DOE Office of Scientific and Technical Information (OSTI.GOV)

Zhang, Xuejun; Tang, Qiuhong; Liu, Xingcai

Real-time monitoring and predicting drought development with several months in advance is of critical importance for drought risk adaptation and mitigation. In this paper, we present a drought monitoring and seasonal forecasting framework based on the Variable Infiltration Capacity (VIC) hydrologic model over Southwest China (SW). The satellite precipitation data are used to force VIC model for near real-time estimate of land surface hydrologic conditions. As initialized with satellite-aided monitoring, the climate model-based forecast (CFSv2_VIC) and ensemble streamflow prediction (ESP)-based forecast (ESP_VIC) are both performed and evaluated through their ability in reproducing the evolution of the 2009/2010 severe drought overmore » SW. The results show that the satellite-aided monitoring is able to provide reasonable estimate of forecast initial conditions (ICs) in a real-time manner. Both of CFSv2_VIC and ESP_VIC exhibit comparable performance against the observation-based estimates for the first month, whereas the predictive skill largely drops beyond 1-month. Compared to ESP_VIC, CFSv2_VIC shows better performance as indicated by the smaller ensemble range. This study highlights the value of this operational framework in generating near real-time ICs and giving a reliable prediction with 1-month ahead, which has great implications for drought risk assessment, preparation and relief.« less

Thrust vector control of upper stage with a gimbaled thruster during orbit transfer

NASA Astrophysics Data System (ADS)

Wang, Zhaohui; Jia, Yinghong; Jin, Lei; Duan, Jiajia

2016-10-01

In launching Multi-Satellite with One-Vehicle, the main thruster provided by the upper stage is mounted on a two-axis gimbal. During orbit transfer, the thrust vector of this gimbaled thruster (GT) should theoretically pass through the mass center of the upper stage and align with the command direction to provide orbit transfer impetus. However, it is hard to be implemented from the viewpoint of the engineering mission. The deviations of the thrust vector from the command direction would result in large velocity errors. Moreover, the deviations of the thrust vector from the upper stage mass center would produce large disturbance torques. This paper discusses the thrust vector control (TVC) of the upper stage during its orbit transfer. Firstly, the accurate nonlinear coupled kinematic and dynamic equations of the upper stage body, the two-axis gimbal and the GT are derived by taking the upper stage as a multi-body system. Then, a thrust vector control system consisting of the special attitude control of the upper stage and the gimbal rotation of the gimbaled thruster is proposed. The special attitude control defined by the desired attitude that draws the thrust vector to align with the command direction when the gimbal control makes the thrust vector passes through the upper stage mass center. Finally, the validity of the proposed method is verified through numerical simulations.

Karyotype Analysis of Four Vicia Species using In Situ Hybridization with Repetitive Sequences

PubMed Central

NAVRÁTILOVÁ, ALICE; NEUMANN, PAVEL; MACAS, JIŘÍ

2003-01-01

Mitotic chromosomes of four Vicia species (V. sativa, V. grandiflora, V. pannonica and V. narbonensis) were subjected to in situ hybridization with probes derived from conserved plant repetitive DNA sequences (18S–25S and 5S rDNA, telomeres) and genus‐specific satellite repeats (VicTR‐A and VicTR‐B). Numbers and positions of hybridization signals provided cytogenetic landmarks suitable for unambiguous identification of all chromosomes, and establishment of the karyotypes. The VicTR‐A and ‐B sequences, in particular, produced highly informative banding patterns that alone were sufficient for discrimination of all chromosomes. However, these patterns were not conserved among species and thus could not be employed for identification of homologous chromosomes. This fact, together with observed variations in positions and numbers of rDNA loci, suggests considerable divergence between karyotypes of the species studied. PMID:12770847

The two-component system VicRK regulates functions associated with Streptococcus mutans resistance to complement immunity.

PubMed

Alves, Livia A; Harth-Chu, Erika N; Palma, Thais H; Stipp, Rafael N; Mariano, Flávia S; Höfling, José F; Abranches, Jacqueline; Mattos-Graner, Renata O

2017-10-01

Streptococcus mutans, a dental caries pathogen, can promote systemic infections upon reaching the bloodstream. The two-component system (TCS) VicRK Sm of S. mutans regulates the synthesis of and interaction with sucrose-derived exopolysaccharides (EPS), processes associated with oral and systemic virulence. In this study, we investigated the mechanisms by which VicRK Sm affects S. mutans susceptibility to blood-mediated immunity. Compared with parent strain UA159, the vicK Sm isogenic mutant (UAvic) showed reduced susceptibility to deposition of C3b of complement, low binding to serum immunoglobulin G (IgG), and low frequency of C3b/IgG-mediated opsonophagocytosis by polymorphonuclear cells in a sucrose-independent way (P<.05). Reverse transcriptase quantitative polymerase chain reaction analysis comparing gene expression in UA159 and UAvic revealed that genes encoding putative peptidases of the complement (pepO and smu.399) were upregulated in UAvic in the presence of serum, although genes encoding murein hydrolases (SmaA and Smu.2146c) or metabolic/surface proteins involved in bacterial interactions with host components (enolase, GAPDH) were mostly affected in a serum-independent way. Among vicK Sm -downstream genes (smaA, smu.2146c, lysM, atlA, pepO, smu.399), only pepO and smu.399 were associated with UAvic phenotypes; deletion of both genes in UA159 significantly enhanced levels of C3b deposition and opsonophagocytosis (P<.05). Moreover, consistent with the fibronectin-binding function of PepO orthologues, UAvic showed increased binding to fibronectin. Reduced susceptibility to opsonophagocytosis was insufficient to enhance ex vivo persistence of UAvic in blood, which was associated with growth defects of this mutant under limited nutrient conditions. Our findings revealed that S. mutans employs mechanisms of complement evasion through peptidases, which are controlled by VicRK Sm. © 2017 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

“ How Reliable is the Couple of WRF & VIC Models”

EPA Science Inventory

The ability of the fully coupling of Weather Research & Forecasting Model (WRF) and Variable Infiltration Capacity (VIC) model to produce hydrological and climate variables was evaluated. First, the VIC model was run by using observed meteorological data and calibrated in the Upp...

The virtual infinite capacitor

NASA Astrophysics Data System (ADS)

Yona, Guy; Weiss, George

2017-01-01

We define the virtual infinite capacitor (VIC) as a nonlinear capacitor that has the property that for an interval of the charge Q (the operating range), the voltage V remains constant. We propose a lossless approximate realisation for the VIC as a simple circuit with two controllers: a voltage controller acts fast to maintain the desired terminal voltage, while a charge controller acts more slowly and maintains the charge Q in the desired operating range by influencing the incoming current. The VIC is useful as a filter capacitor for various applications, for example, power factor compensators (PFC), as we describe. In spite of using small capacitors, the VIC can replace a very large capacitor in applications that do not require substantial energy storage. We give simulation results for a PFC working in critical conduction mode with a VIC for output voltage filtering.

An experimental seasonal hydrological forecasting system over the Yellow River basin – Part 2: The added value from climate forecast models

DOE PAGES

Yuan, Xing

2016-06-22

This is the second paper of a two-part series on introducing an experimental seasonal hydrological forecasting system over the Yellow River basin in northern China. While the natural hydrological predictability in terms of initial hydrological conditions (ICs) is investigated in a companion paper, the added value from eight North American Multimodel Ensemble (NMME) climate forecast models with a grand ensemble of 99 members is assessed in this paper, with an implicit consideration of human-induced uncertainty in the hydrological models through a post-processing procedure. The forecast skill in terms of anomaly correlation (AC) for 2 m air temperature and precipitation does not necessarily decrease overmore » leads but is dependent on the target month due to a strong seasonality for the climate over the Yellow River basin. As there is more diversity in the model performance for the temperature forecasts than the precipitation forecasts, the grand NMME ensemble mean forecast has consistently higher skill than the best single model up to 6 months for the temperature but up to 2 months for the precipitation. The NMME climate predictions are downscaled to drive the variable infiltration capacity (VIC) land surface hydrological model and a global routing model regionalized over the Yellow River basin to produce forecasts of soil moisture, runoff and streamflow. And the NMME/VIC forecasts are compared with the Ensemble Streamflow Prediction method (ESP/VIC) through 6-month hindcast experiments for each calendar month during 1982–2010. As verified by the VIC offline simulations, the NMME/VIC is comparable to the ESP/VIC for the soil moisture forecasts, and the former has higher skill than the latter only for the forecasts at long leads and for those initialized in the rainy season. The forecast skill for runoff is lower for both forecast approaches, but the added value from NMME/VIC is more obvious, with an increase of the average AC by 0.08–0.2. To compare with the observed streamflow, both the hindcasts from NMME/VIC and ESP/VIC are post-processed through a linear regression model fitted by using VIC offline-simulated streamflow. The post-processed NMME/VIC reduces the root mean squared error (RMSE) from the post-processed ESP/VIC by 5–15 %. And the reduction occurs mostly during the transition from wet to dry seasons. As a result, with the consideration of the uncertainty in the hydrological models, the added value from climate forecast models is decreased especially at short leads, suggesting the necessity of improving the large-scale hydrological models in human-intervened river basins.« less

An experimental seasonal hydrological forecasting system over the Yellow River basin – Part 2: The added value from climate forecast models

DOE Office of Scientific and Technical Information (OSTI.GOV)

Yuan, Xing

This is the second paper of a two-part series on introducing an experimental seasonal hydrological forecasting system over the Yellow River basin in northern China. While the natural hydrological predictability in terms of initial hydrological conditions (ICs) is investigated in a companion paper, the added value from eight North American Multimodel Ensemble (NMME) climate forecast models with a grand ensemble of 99 members is assessed in this paper, with an implicit consideration of human-induced uncertainty in the hydrological models through a post-processing procedure. The forecast skill in terms of anomaly correlation (AC) for 2 m air temperature and precipitation does not necessarily decrease overmore » leads but is dependent on the target month due to a strong seasonality for the climate over the Yellow River basin. As there is more diversity in the model performance for the temperature forecasts than the precipitation forecasts, the grand NMME ensemble mean forecast has consistently higher skill than the best single model up to 6 months for the temperature but up to 2 months for the precipitation. The NMME climate predictions are downscaled to drive the variable infiltration capacity (VIC) land surface hydrological model and a global routing model regionalized over the Yellow River basin to produce forecasts of soil moisture, runoff and streamflow. And the NMME/VIC forecasts are compared with the Ensemble Streamflow Prediction method (ESP/VIC) through 6-month hindcast experiments for each calendar month during 1982–2010. As verified by the VIC offline simulations, the NMME/VIC is comparable to the ESP/VIC for the soil moisture forecasts, and the former has higher skill than the latter only for the forecasts at long leads and for those initialized in the rainy season. The forecast skill for runoff is lower for both forecast approaches, but the added value from NMME/VIC is more obvious, with an increase of the average AC by 0.08–0.2. To compare with the observed streamflow, both the hindcasts from NMME/VIC and ESP/VIC are post-processed through a linear regression model fitted by using VIC offline-simulated streamflow. The post-processed NMME/VIC reduces the root mean squared error (RMSE) from the post-processed ESP/VIC by 5–15 %. And the reduction occurs mostly during the transition from wet to dry seasons. As a result, with the consideration of the uncertainty in the hydrological models, the added value from climate forecast models is decreased especially at short leads, suggesting the necessity of improving the large-scale hydrological models in human-intervened river basins.« less

Quantitative Evaluation of E1 Endoglucanase Recovery from Tobacco Leaves Using the Vacuum Infiltration-Centrifugation Method

PubMed Central

Kingsbury, Nathaniel J.; McDonald, Karen A.

2014-01-01

As a production platform for recombinant proteins, plant leaf tissue has many advantages, but commercialization of this technology has been hindered by high recovery and purification costs. Vacuum infiltration-centrifugation (VI-C) is a technique to obtain extracellularly-targeted products from the apoplast wash fluid (AWF). Because of its selective recovery of secreted proteins without homogenizing the whole tissue, VI-C can potentially reduce downstream production costs. Lab scale experiments were conducted to quantitatively evaluate the VI-C method and compared to homogenization techniques in terms of product purity, concentration, and other desirable characteristics. From agroinfiltrated Nicotiana benthamiana leaves, up to 81% of a truncated version of E1 endoglucanase from Acidothermus cellulolyticus was recovered with VI-C versus homogenate extraction, and average purity and concentration increases of 4.2-fold and 3.1-fold, respectively, were observed. Formulas were developed to predict recovery yields of secreted protein obtained by performing multiple rounds of VI-C on the same leaf tissue. From this, it was determined that three rounds of VI-C recovered 97% of the total active recombinant protein accessible to the VI-C procedure. The results suggest that AWF recovery is an efficient process that could reduce downstream processing steps and costs for plant-made recombinant proteins. PMID:24971334

Language-in-Education Policies, Immigration and Social Cohesion in Catalonia: The Case of Vic

ERIC Educational Resources Information Center

Edwards, Catrin Wyn

2016-01-01

This paper analyses the language-in-education policies implemented to integrate international immigrants into the Catalan language community in Vic, Catalonia. It focuses on the Catalan Government's "Languages and Social Cohesion Plan" (LIC) plan, Vic city council's local education plans, which were adopted as part of LIC plan, and the…

Engineering super mycovirus donor strains of chestnut blight fungus by systematic disruption of multilocus vic genes.

PubMed

Zhang, Dong-Xiu; Nuss, Donald L

2016-02-23

Transmission of mycoviruses that attenuate virulence (hypovirulence) of pathogenic fungi is restricted by allorecognition systems operating in their fungal hosts. We report the use of systematic molecular gene disruption and classical genetics for engineering fungal hosts with superior virus transmission capabilities. Four of five diallelic virus-restricting allorecognition [vegetative incompatibility (vic)] loci were disrupted in the chestnut blight fungus Cryphonectria parasitica using an adapted Cre-loxP recombination system that allowed excision and recycling of selectable marker genes (SMGs). SMG-free, quadruple vic mutant strains representing both allelic backgrounds of the remaining vic locus were then produced through mating. In combination, these super donor strains were able to transmit hypoviruses to strains that were heteroallelic at one or all of the virus-restricting vic loci. These results demonstrate the feasibility of modulating allorecognition to engineer pathogenic fungi for more efficient transmission of virulence-attenuating mycoviruses and enhanced biological control potential.

Triethylene Glycol Up-Regulates Virulence-Associated Genes and Proteins in Streptococcus mutans.

PubMed

Sadeghinejad, Lida; Cvitkovitch, Dennis G; Siqueira, Walter L; Santerre, J Paul; Finer, Yoav

2016-01-01

Triethylene glycol dimethacrylate (TEGDMA) is a diluent monomer used pervasively in dental composite resins. Through hydrolytic degradation of the composites in the oral cavity it yields a hydrophilic biodegradation product, triethylene glycol (TEG), which has been shown to promote the growth of Streptococcus mutans, a dominant cariogenic bacterium. Previously it was shown that TEG up-regulated gtfB, an important gene contributing to polysaccharide synthesis function in biofilms. However, molecular mechanisms related to TEG's effect on bacterial function remained poorly understood. In the present study, S. mutans UA159 was incubated with clinically relevant concentrations of TEG at pH 5.5 and 7.0. Quantitative real-time PCR, proteomics analysis, and glucosyltransferase enzyme (GTF) activity measurements were employed to identify the bacterial phenotypic response to TEG. A S. mutans vicK isogenic mutant (SMΔvicK1) and its associated complemented strain (SMΔvicK1C), an important regulatory gene for biofilm-associated genes, were used to determine if this signaling pathway was involved in modulation of the S. mutans virulence-associated genes. Extracted proteins from S. mutans biofilms grown in the presence and absence of TEG were subjected to mass spectrometry for protein identification, characterization and quantification. TEG up-regulated gtfB/C, gbpB, comC, comD and comE more significantly in biofilms at cariogenic pH (5.5) and defined concentrations. Differential response of the vicK knock-out (SMΔvicK1) and complemented strains (SMΔvicK1C) implicated this signalling pathway in TEG-modulated cellular responses. TEG resulted in increased GTF enzyme activity, responsible for synthesizing insoluble glucans involved in the formation of cariogenic biofilms. As well, TEG increased protein abundance related to biofilm formation, carbohydrate transport, acid tolerance, and stress-response. Proteomics data was consistent with gene expression findings for the selected genes. These findings demonstrate a mechanistic pathway by which TEG derived from commercial resin materials in the oral cavity promote S. mutans pathogenicity, which is typically associated with secondary caries.

Triethylene Glycol Up-Regulates Virulence-Associated Genes and Proteins in Streptococcus mutans

PubMed Central

Sadeghinejad, Lida; Cvitkovitch, Dennis G.; Siqueira, Walter L.; Santerre, J. Paul; Finer, Yoav

2016-01-01

Triethylene glycol dimethacrylate (TEGDMA) is a diluent monomer used pervasively in dental composite resins. Through hydrolytic degradation of the composites in the oral cavity it yields a hydrophilic biodegradation product, triethylene glycol (TEG), which has been shown to promote the growth of Streptococcus mutans, a dominant cariogenic bacterium. Previously it was shown that TEG up-regulated gtfB, an important gene contributing to polysaccharide synthesis function in biofilms. However, molecular mechanisms related to TEG’s effect on bacterial function remained poorly understood. In the present study, S. mutans UA159 was incubated with clinically relevant concentrations of TEG at pH 5.5 and 7.0. Quantitative real-time PCR, proteomics analysis, and glucosyltransferase enzyme (GTF) activity measurements were employed to identify the bacterial phenotypic response to TEG. A S. mutans vicK isogenic mutant (SMΔvicK1) and its associated complemented strain (SMΔvicK1C), an important regulatory gene for biofilm-associated genes, were used to determine if this signaling pathway was involved in modulation of the S. mutans virulence-associated genes. Extracted proteins from S. mutans biofilms grown in the presence and absence of TEG were subjected to mass spectrometry for protein identification, characterization and quantification. TEG up-regulated gtfB/C, gbpB, comC, comD and comE more significantly in biofilms at cariogenic pH (5.5) and defined concentrations. Differential response of the vicK knock-out (SMΔvicK1) and complemented strains (SMΔvicK1C) implicated this signalling pathway in TEG-modulated cellular responses. TEG resulted in increased GTF enzyme activity, responsible for synthesizing insoluble glucans involved in the formation of cariogenic biofilms. As well, TEG increased protein abundance related to biofilm formation, carbohydrate transport, acid tolerance, and stress-response. Proteomics data was consistent with gene expression findings for the selected genes. These findings demonstrate a mechanistic pathway by which TEG derived from commercial resin materials in the oral cavity promote S. mutans pathogenicity, which is typically associated with secondary caries. PMID:27820867

Low Cost Science Teaching Equipment for Visually Impaired Children

NASA Astrophysics Data System (ADS)

Gupta, H. O.; Singh, Rakshpal

1998-05-01

A low cost null detector an electronic thermometer and a colorimeter have been designed and developed for enabling visually impaired children (VIC) to do experiments in science that normally are accessible only to sighted children. The instruments are based on audio null detection in a balanced bridge and use a themistor for sensing the temperature and an LDR for color change. The analog output can be tactually read by VIC. The equipment has been tested for suitability with VIC. The approach followed in developing these equipment would be generally appropriate to a wide variety of science equipment for VIC by incorporating suitable sensors.

Basin-scale assessment of the land surface energy budget in the National Centers for Environmental Prediction operational and research NLDAS-2 systems

NASA Astrophysics Data System (ADS)

Xia, Youlong; Cosgrove, Brian A.; Mitchell, Kenneth E.; Peters-Lidard, Christa D.; Ek, Michael B.; Kumar, Sujay; Mocko, David; Wei, Helin

2016-01-01

This paper compares the annual and monthly components of the simulated energy budget from the North American Land Data Assimilation System phase 2 (NLDAS-2) with reference products over the domains of the 12 River Forecast Centers (RFCs) of the continental United States (CONUS). The simulations are calculated from both operational and research versions of NLDAS-2. The reference radiation components are obtained from the National Aeronautics and Space Administration Surface Radiation Budget product. The reference sensible and latent heat fluxes are obtained from a multitree ensemble method applied to gridded FLUXNET data from the Max Planck Institute, Germany. As these references are obtained from different data sources, they cannot fully close the energy budget, although the range of closure error is less than 15% for mean annual results. The analysis here demonstrates the usefulness of basin-scale surface energy budget analysis for evaluating model skill and deficiencies. The operational (i.e., Noah, Mosaic, and VIC) and research (i.e., Noah-I and VIC4.0.5) NLDAS-2 land surface models exhibit similarities and differences in depicting basin-averaged energy components. For example, the energy components of the five models have similar seasonal cycles, but with different magnitudes. Generally, Noah and VIC overestimate (underestimate) sensible (latent) heat flux over several RFCs of the eastern CONUS. In contrast, Mosaic underestimates (overestimates) sensible (latent) heat flux over almost all 12 RFCs. The research Noah-I and VIC4.0.5 versions show moderate-to-large improvements (basin and model dependent) relative to their operational versions, which indicates likely pathways for future improvements in the operational NLDAS-2 system.

Basin-Scale Assessment of the Land Surface Energy Budget in the National Centers for Environmental Prediction Operational and Research NLDAS-2 Systems

NASA Technical Reports Server (NTRS)

Xia, Youlong; Peters-Lidard, Christa D.; Cosgrove, Brian A.; Mitchell, Kenneth E.; Peters-Lidard, Christa; Ek, Michael B.; Kumar, Sujay V.; Mocko, David M.; Wei, Helin

2015-01-01

This paper compares the annual and monthly components of the simulated energy budget from the North American Land Data Assimilation System phase 2 (NLDAS-2) with reference products over the domains of the 12 River Forecast Centers (RFCs) of the continental United States (CONUS). The simulations are calculated from both operational and research versions of NLDAS-2. The reference radiation components are obtained from the National Aeronautics and Space Administration Surface Radiation Budget product. The reference sensible and latent heat fluxes are obtained from a multitree ensemble method applied to gridded FLUXNET data from the Max Planck Institute, Germany. As these references are obtained from different data sources, they cannot fully close the energy budget, although the range of closure error is less than 15%formean annual results. The analysis here demonstrates the usefulness of basin-scale surface energy budget analysis for evaluating model skill and deficiencies. The operational (i.e., Noah, Mosaic, and VIC) and research (i.e., Noah-I and VIC4.0.5) NLDAS-2 land surface models exhibit similarities and differences in depicting basin-averaged energy components. For example, the energy components of the five models have similar seasonal cycles, but with different magnitudes. Generally, Noah and VIC overestimate (underestimate) sensible (latent) heat flux over several RFCs of the eastern CONUS. In contrast, Mosaic underestimates (overestimates) sensible (latent) heat flux over almost all 12 RFCs. The research Noah-I and VIC4.0.5 versions show moderate-to-large improvements (basin and model dependent) relative to their operational versions, which indicates likely pathways for future improvements in the operational NLDAS-2 system.

Analysis of Water Use and Water Scarcity in Arid and Semi-arid Regions

NASA Astrophysics Data System (ADS)

Samayoa, S. D.

2017-12-01

Analysis of Water Use and Water Scarcity in Arid and Semi-arid Regions Susana Samayoa , Muhammed A. G. Chowdhury, Tushar Sinha Department of Environmental Engineering, Texas A & M University - Kingsville Freshwater sustainability in arid and semi-arid regions is highly uncertain under increasing demands due to population growth and urban development as well as limited water supply. In particular, six largest cities by population among the top twenty U.S. cities are located in Texas (TX), which also experience high variability in water availability due to frequent droughts and floods. Similarly, several regions in Arizona (AZ) are rapidly growing (e.g. Phoenix and Tucson) despite receiving scanty rainfall. Thus, the goal of this study is to analyze water use and water scarcity in watersheds within TX and AZ between 1985 and 2010. The water use data from U.S. Geological Survey (USGS) is analyzed by Hydrological Unit Code (HUC) - 8 within TX and AZ. Total freshwater use by county during 1985 and 2010 were converted into water use by HUC-8 using geospatial analysis. Water availability will be estimated by using a large scale Variable Infiltration Capacity (VIC) hydrologic model. The VIC model will be calibrated and validated for multiple basins located in Texas and Arizona. The VIC model simulated total streamflow will be aggregated across the 1/8 degree grids that are within each HUC-8 to estimate water supply. The excess water for upstream HUC-8s (= local supply minus demands) will be routed, in addition to locally generated streamflow, to estimate water availability in downstream HUC-8s. Water Scarcity Index, defined as the ratio of total freshwater demand to supply, will be estimated during 1985 and 2010 to evaluate the effects of water availability and demands on scarcity. Finally, water scarcity and use will be analyzed by HUC-8s within TX and AZ. Such information could be useful in water resources management and planning. Keywords: Water scarcity, water use, water supply, VIC

How reliable is the offline linkage of Weather Research & Forecasting Model (WRF) and Variable Infiltration Capacity (VIC) model?

EPA Science Inventory

The aim for this research is to evaluate the ability of the offline linkage of Weather Research & Forecasting Model (WRF) and Variable Infiltration Capacity (VIC) model to produce hydrological, e.g. evaporation (ET), soil moisture (SM), runoff, and baseflow. First, the VIC mo...

Observed SWE trends and climate analysis for Northwest Pacific North America: validation for future projection of SWE using the CRCM and VIC

NASA Astrophysics Data System (ADS)

Bennett, K. E.; Bronaugh, D.; Rodenhuis, D.

2008-12-01

Observational databases of snow water equivalent (SWE) have been collected from Alaska, western US states and the Canadian provinces of British Columbia, Alberta, Saskatchewan, and territories of NWT, and the Yukon. These databases were initially validated to remove inconsistencies and errors in the station records, dates or the geographic co-ordinates of the station. The cleaned data was then analysed for historical (1950 to 2006) trend using emerging techniques for trend detection based on (first of the month) estimates for January to June. Analysis of SWE showed spatial variability in the count of records across the six month time period, and this study illustrated differences between Canadian and US (or the north and south) collection. Two different data sets (one gridded and one station) were then used to analyse April 1st records, for which there was the greatest spatial spread of station records for analysis with climate information. Initial results show spatial variability (in both magnitude and direction of trend) for trend results, and climate correlations and principal components indicate different drivers of change in SWE across the western US, Canada and north to Alaska. These results will be used to validate future predictions of SWE that are being undertaken using the Canadian Regional Climate Model (CRCM) and the Variable Infiltration Capacity (VIC) hydrologic model for Western Northern America (CRCM) and British Columbia (VIC).

Two-component system VicRK regulates functions associated with establishment of Streptococcus sanguinis in biofilms.

PubMed

Moraes, Julianna J; Stipp, Rafael N; Harth-Chu, Erika N; Camargo, Tarsila M; Höfling, José F; Mattos-Graner, Renata O

2014-12-01

Streptococcus sanguinis is a commensal pioneer colonizer of teeth and an opportunistic pathogen of infectious endocarditis. The establishment of S. sanguinis in host sites likely requires dynamic fitting of the cell wall in response to local stimuli. In this study, we investigated the two-component system (TCS) VicRK in S. sanguinis (VicRKSs), which regulates genes of cell wall biogenesis, biofilm formation, and virulence in opportunistic pathogens. A vicK knockout mutant obtained from strain SK36 (SKvic) showed slight reductions in aerobic growth and resistance to oxidative stress but an impaired ability to form biofilms, a phenotype restored in the complemented mutant. The biofilm-defective phenotype was associated with reduced amounts of extracellular DNA during aerobic growth, with reduced production of H2O2, a metabolic product associated with DNA release, and with inhibitory capacity of S. sanguinis competitor species. No changes in autolysis or cell surface hydrophobicity were detected in SKvic. Reverse transcription-quantitative PCR (RT-qPCR), electrophoretic mobility shift assays (EMSA), and promoter sequence analyses revealed that VicR directly regulates genes encoding murein hydrolases (SSA_0094, cwdP, and gbpB) and spxB, which encodes pyruvate oxidase for H2O2 production. Genes previously associated with spxB expression (spxR, ccpA, ackA, and tpK) were not transcriptionally affected in SKvic. RT-qPCR analyses of S. sanguinis biofilm cells further showed upregulation of VicRK targets (spxB, gbpB, and SSA_0094) and other genes for biofilm formation (gtfP and comE) compared to expression in planktonic cells. This study provides evidence that VicRKSs regulates functions crucial for S. sanguinis establishment in biofilms and identifies novel VicRK targets potentially involved in hydrolytic activities of the cell wall required for these functions. Copyright © 2014, American Society for Microbiology. All Rights Reserved.

Two-Component System VicRK Regulates Functions Associated with Establishment of Streptococcus sanguinis in Biofilms

PubMed Central

Moraes, Julianna J.; Stipp, Rafael N.; Harth-Chu, Erika N.; Camargo, Tarsila M.; Höfling, José F.

2014-01-01

Streptococcus sanguinis is a commensal pioneer colonizer of teeth and an opportunistic pathogen of infectious endocarditis. The establishment of S. sanguinis in host sites likely requires dynamic fitting of the cell wall in response to local stimuli. In this study, we investigated the two-component system (TCS) VicRK in S. sanguinis (VicRKSs), which regulates genes of cell wall biogenesis, biofilm formation, and virulence in opportunistic pathogens. A vicK knockout mutant obtained from strain SK36 (SKvic) showed slight reductions in aerobic growth and resistance to oxidative stress but an impaired ability to form biofilms, a phenotype restored in the complemented mutant. The biofilm-defective phenotype was associated with reduced amounts of extracellular DNA during aerobic growth, with reduced production of H2O2, a metabolic product associated with DNA release, and with inhibitory capacity of S. sanguinis competitor species. No changes in autolysis or cell surface hydrophobicity were detected in SKvic. Reverse transcription-quantitative PCR (RT-qPCR), electrophoretic mobility shift assays (EMSA), and promoter sequence analyses revealed that VicR directly regulates genes encoding murein hydrolases (SSA_0094, cwdP, and gbpB) and spxB, which encodes pyruvate oxidase for H2O2 production. Genes previously associated with spxB expression (spxR, ccpA, ackA, and tpK) were not transcriptionally affected in SKvic. RT-qPCR analyses of S. sanguinis biofilm cells further showed upregulation of VicRK targets (spxB, gbpB, and SSA_0094) and other genes for biofilm formation (gtfP and comE) compared to expression in planktonic cells. This study provides evidence that VicRKSs regulates functions crucial for S. sanguinis establishment in biofilms and identifies novel VicRK targets potentially involved in hydrolytic activities of the cell wall required for these functions. PMID:25183732

Heterogeneous Heterobimetallic Catalysis Enabling Expeditious Access to CF3-Containing vic-Amino Alcohols.

PubMed

Karasawa, Tomoya; Kumagai, Naoya; Shibasaki, Masakatsu

2018-01-05

A highly anti-selective catalytic asymmetric nitroaldol reaction of trifluoromethyl ketones based on Nd/Na and Pr/Na heterobimetallic catalysts was developed. These catalysts function as heterogeneous catalysts to engage nitroethane and a range of trifluoromethyl ketones in a stereoselective assembly to afford CF 3 -appended vic-nitroalkanols that could be readily converted to enantioenriched vic-amino alcohols, which are privileged structural motifs in medicinal chemistry.

On the development of a VIPARnd radiotherapy 3D polymer gel dosimeter

NASA Astrophysics Data System (ADS)

Kozicki, Marek; Jaszczak, Malwina; Maras, Piotr; Dudek, Mariusz; Cłapa, Marian

2017-02-01

This work presents an improvement of the VIPARnd (‘nd’ stands for ‘normoxic, double’, or VIP) polymer gel dosimeter. The gel composition was altered by increasing the concentration of the monomeric components, N-vinylpyrrolidone (NVP) and N,N‧-methylenebisacrylamide (MBA), in co-solvent solutions. The optimal composition (VIPARCT, where ‘CT’ stands for computed tomography, or VIC) comprised: 17% NVP, 8% MBA, 12% t-BuOH, 7.5% gelatine, 0.007% ascorbic acid, 0.0008% CuSO4  ×  5H2O and 0.02% hydroquinone. The following characteristics of VIC were achieved: (i) linear dose range of 0.9_30 Gy, (ii) saturation for radiation doses of over 50 Gy, (iii) threshold dose of about 0.5 Gy, (iv) dose sensitivity of 0.171 Gy-1 s-1, which is roughly 2.2 times higher than that of VIP (for nuclear magnetic resonance measurements). It was also found that VIC is dose- rate-independent, and its dose response does not alter if the radiation source is changed from electrons to photons for external beam radiotherapy. The gel responded similarly to irradiation with small changes in radiation energy but was sensitive to larger energy changes. The VIC gel retained temporal stability from 20 h until at least 10 d after irradiation, whereas spatial stability was retained from 20 h until at least 6 d after irradiation. The scheme adopted for VIC manufacturing yields repeatable gels in terms of radiation dose response. The VIC was also shown to perform better than VIP using x-ray computed tomography as a readout method; the dose sensitivity of VIC (0.397 HU Gy-1) was 1.5 times higher than that of VIP. Also, the dose resolution of VIC was better than that of VIP in the whole dose range examined.

Global Sensitivity of Simulated Water Balance Indicators Under Future Climate Change in the Colorado Basin

DOE PAGES

Bennett, Katrina Eleanor; Urrego Blanco, Jorge Rolando; Jonko, Alexandra; ...

2017-11-20

The Colorado River basin is a fundamentally important river for society, ecology and energy in the United States. Streamflow estimates are often provided using modeling tools which rely on uncertain parameters; sensitivity analysis can help determine which parameters impact model results. Despite the fact that simulated flows respond to changing climate and vegetation in the basin, parameter sensitivity of the simulations under climate change has rarely been considered. In this study, we conduct a global sensitivity analysis to relate changes in runoff, evapotranspiration, snow water equivalent and soil moisture to model parameters in the Variable Infiltration Capacity (VIC) hydrologic model.more » Here, we combine global sensitivity analysis with a space-filling Latin Hypercube sampling of the model parameter space and statistical emulation of the VIC model to examine sensitivities to uncertainties in 46 model parameters following a variance-based approach.« less

Global Sensitivity of Simulated Water Balance Indicators Under Future Climate Change in the Colorado Basin

DOE Office of Scientific and Technical Information (OSTI.GOV)

Bennett, Katrina Eleanor; Urrego Blanco, Jorge Rolando; Jonko, Alexandra

The Colorado River basin is a fundamentally important river for society, ecology and energy in the United States. Streamflow estimates are often provided using modeling tools which rely on uncertain parameters; sensitivity analysis can help determine which parameters impact model results. Despite the fact that simulated flows respond to changing climate and vegetation in the basin, parameter sensitivity of the simulations under climate change has rarely been considered. In this study, we conduct a global sensitivity analysis to relate changes in runoff, evapotranspiration, snow water equivalent and soil moisture to model parameters in the Variable Infiltration Capacity (VIC) hydrologic model.more » Here, we combine global sensitivity analysis with a space-filling Latin Hypercube sampling of the model parameter space and statistical emulation of the VIC model to examine sensitivities to uncertainties in 46 model parameters following a variance-based approach.« less

Results of neurolysis in established upper limb Volkmann's ischemic contracture

PubMed Central

Meena, Dinesh K; Thalanki, Srikiran; Patni, Poornima; Meena, Ram Khiladi; Bairawa, Dinesh; Bhatia, Chirag

2016-01-01

Background: Treatment of established cases of Volkmann's ischemic contracture (VIC) of upper limb is very tedious. Since the period of Volkmann, various experimental works are being performed for its treatment, but none are effective. Disabilities from nerve palsy and hand muscle paralysis are more problematic than any other deformity in VIC. To solve these problems, we conducted a study to see the result of neurolysis of median and ulnar nerve and their subcutaneous placement in established cases of VIC. Materials and Methods: Twelve cases of established VIC operated between July 2007 and August 2010 with complete records and followup were included in the study. VIC of lower limb and contracture of nonischemic etiology were excluded from the study. Their evaluation was done by the British Medical Research Council grading system for sensory and motor recovery. Followup was done for an average period of 24.3 months (range 15-30 months) (the average age was 8.3 years). Results: To study the results, we divided the cases into two series. One group consisted of cases which were operated within 6 months from onset of VIC. The second group consisted of cases which were operated after 6 months from onset of VIC. Our results revealed that there was no statistically significant difference between the two groups operated, though both had significant improvement in motor and sensory recovery in both median and ulnar nerve distribution. Conclusions: Neurolysis of the nerves definitely improved the outcome for motor and sensory components of median and ulnar nerves but the timing of the surgery did not play a role in the outcome contrary to the clinical assumption. This study can serve as a template and further such studies could help us find the answer to a long standing issue. PMID:27904214

Denosumab could be a Potential Inhibitor of Valvular Interstitial Cells Calcification in vitro.

PubMed

Lerman, Daniel Alejandro; Prasad, Sai; Alotti, Nasri

2016-01-03

Denosumab is a fully human monoclonal antibody and novel antiresorptive agent that works by binding receptor activator of nuclear factor kappa-β ligand (RANKL) and inhibiting the signaling cascade that causes osteoclast maturation, activity, and survival. We aimed to elucidate the effect of Denosumab in the process of spontaneous and induced calcification in an in vitro porcine valvular interstitial cells (VICs) model. VICs were extracted from fresh porcine hearts by serial collagenase digestion. Spontaneous calcification of VICs was increased in vitro by adding Na 3 PO 4 (3 mM, pH 7.4) and different concentrations (0.1, 1 and 10 ng/ml) of transforming growth factor beta (TGFß). The degree of calcification before and after treatment with Denosumab was estimated by Alizarin Red staining for calcium deposition, and Sirius Red staining for collagen. Colorimetric techniques were used to determine calcium and collagen deposition quantitatively. For statistical analysis we used SPSS and Microsoft Office Excel 2013. Porcine aortic VICs in vitro were induced to calcify by the addition of either 3 mM Na 3 PO 4 , showing a 5.2 fold increase by 14 days (P<0.001), or 3 mM Na 3 PO 4 + 10 ng/ml of TGFβ, showing a 7 fold increase by Day 14 (P<0.001). Denosumab inhibited induced calcification by 3 mM Na 3 PO 4 and 3 mM Na 3 PO 4 with the addition of TGFß at either 0.1, 1 or 10 ng/ml to basal levels only at a concentration of 50 μg/ml (P<0.001). This study has proved that Denosumab could be a potential inhibitor of the calcification of VICs in vitro . A fuller understanding of the actions of Denosumab may identify a novel therapeutic strategy for clinical intervention against aortic valve calcification and aortic stenosis.

Wheel speed management control system for spacecraft

NASA Technical Reports Server (NTRS)

Goodzeit, Neil E. (Inventor); Linder, David M. (Inventor)

1991-01-01

A spacecraft attitude control system uses at least four reaction wheels. In order to minimize reaction wheel speed and therefore power, a wheel speed management system is provided. The management system monitors the wheel speeds and generates a wheel speed error vector. The error vector is integrated, and the error vector and its integral are combined to form a correction vector. The correction vector is summed with the attitude control torque command signals for driving the reaction wheels.

Downregulation of GbpB, a Component of the VicRK Regulon, Affects Biofilm Formation and Cell Surface Characteristics of Streptococcus mutans▿ †

PubMed Central

Duque, Cristiane; Stipp, Rafael N.; Wang, Bing; Smith, Daniel J.; Höfling, José F.; Kuramitsu, Howard K.; Duncan, Margaret J.; Mattos-Graner, Renata O.

2011-01-01

The virulence of the dental caries pathogen Streptococcus mutans relies in part on the sucrose-dependent synthesis of and interaction with glucan, a major component of the extracellular matrix of tooth biofilms. However, the mechanisms by which secreted and/or cell-associated glucan-binding proteins (Gbps) produced by S. mutans participate in biofilm growth remain to be elucidated. In this study, we further investigate GbpB, an essential immunodominant protein with similarity to murein hydrolases. A conditional knockdown mutant that expressed gbpB antisense RNA under the control of a tetracycline-inducible promoter was constructed in strain UA159 (UACA2) and used to investigate the effects of GbpB depletion on biofilm formation and cell surface-associated characteristics. Additionally, regulation of gbpB by the two-component system VicRK was investigated, and phenotypic analysis of a vicK mutant (UAvicK) was performed. GbpB was directly regulated by VicR, and several phenotypic changes were comparable between UACA2 and UAvicK, although differences between these strains existed. It was established that GbpB depletion impaired initial phases of sucrose-dependent biofilm formation, while exogenous native GbpB partially restored the biofilm phenotype. Several cellular traits were significantly affected by GbpB depletion, including altered cell shape, decreased autolysis, increased cell hydrophobicity, and sensitivity to antibiotics and osmotic and oxidative stresses. These data provide the first experimental evidence for GbpB participation in sucrose-dependent biofilm formation and in cell surface properties. PMID:21078847

A Maple package for improved global mapping forecast

NASA Astrophysics Data System (ADS)

Carli, H.; Duarte, L. G. S.; da Mota, L. A. C. P.

2014-03-01

We present a Maple implementation of the well known global approach to time series analysis and some further developments designed to improve the computational efficiency of the forecasting capabilities of the approach. This global approach can be summarized as being a reconstruction of the phase space, based on a time ordered series of data obtained from the system. After that, using the reconstructed vectors, a portion of this space is used to produce a mapping, a polynomial fitting, through a minimization procedure, that represents the system and can be employed to forecast further entries for the series. In the present implementation, we introduce a set of commands, tools, in order to perform all these tasks. For example, the command VecTS deals mainly with the reconstruction of the vector in the phase space. The command GfiTS deals with producing the minimization and the fitting. ForecasTS uses all these and produces the prediction of the next entries. For the non-standard algorithms, we here present two commands: IforecasTS and NiforecasTS that, respectively deal with the one-step and the N-step forecasting. Finally, we introduce two further tools to aid the forecasting. The commands GfiTS and AnalysTS, basically, perform an analysis of the behavior of each portion of a series regarding the settings used on the commands just mentioned above. Catalogue identifier: AERW_v1_0 Program summary URL:http://cpc.cs.qub.ac.uk/summaries/AERW_v1_0.html Program obtainable from: CPC Program Library, Queen’s University, Belfast, N. Ireland Licensing provisions: Standard CPC licence, http://cpc.cs.qub.ac.uk/licence/licence.html No. of lines in distributed program, including test data, etc.: 3001 No. of bytes in distributed program, including test data, etc.: 95018 Distribution format: tar.gz Programming language: Maple 14. Computer: Any capable of running Maple Operating system: Any capable of running Maple. Tested on Windows ME, Windows XP, Windows 7. RAM: 128 MB Classification: 4.3, 4.9, 5 Nature of problem: Time series analysis and improving forecast capability. Solution method: The method of solution is partially based on a result published in [1]. Restrictions: If the time series that is being analyzed presents a great amount of noise or if the dynamical system behind the time series is of high dimensionality (Dim≫3), then the method may not work well. Unusual features: Our implementation can, in the cases where the dynamics behind the time series is given by a system of low dimensionality, greatly improve the forecast. Running time: This depends strongly on the command that is being used. References: [1] Barbosa, L.M.C.R., Duarte, L.G.S., Linhares, C.A. and da Mota, L.A.C.P., Improving the global fitting method on nonlinear time series analysis, Phys. Rev. E 74, 026702 (2006).

Crawling Aid

NASA Technical Reports Server (NTRS)

1982-01-01

The Institute for the Achievement of Human Potential developed a device known as the Vehicle for Initial Crawling (VIC); the acronym is a tribute to the crawler's inventor, Hubert "Vic" Vykukal; is an effective crawling aid. The VIC is used by brain injured children who are unable to crawl due to the problems of weight-bearing and friction, caused by gravity. It is a rounded plywood frame large enough to support the child's torso, leaving arms and legs free to move. On its underside are three aluminum discs through which air is pumped to create an air-bearing surface that has less friction than a film of oil. Upper side contains the connection to the air supply and a pair of straps which restrain the child and cause the device to move with him. VIC is used with the intent to recreate the normal neurological connection between brain and muscles. Over repetitive use of the device the child develops his arm and leg muscles as well as coordination. Children are given alternating therapy, with and without the VIC until eventually the device is no longer needed.

Stability boundaries for command augmentation systems

NASA Technical Reports Server (NTRS)

Shrivastava, P. C.

1987-01-01

The Stability Augmentation System (SAS) is a special case of the Command Augmentation System (CAS). Control saturation imposes bounds on achievable commands. The state equilibrium depends only on the open loop dynamics and control deflection. The control magnitude to achieve a desired command equilibrium is independent of the feedback gain. A feedback controller provides the desired response, maintains the system equilibrium under disturbances, but it does not affect the equilibrium values of states and control. The saturation boundaries change with commands, but the location of the equilibrium points in the saturated region remains unchanged. Nonzero command vectors yield saturation boundaries that are asymmetric with respect to the state equilibrium. Except for the saddle point case with MCE control law, the stability boundaries change with commands. For the cases of saddle point and unstable nodes, the region of stability decreases with increasing command magnitudes.

Short-term climate change impacts on Mara basin hydrology

NASA Astrophysics Data System (ADS)

Demaria, E. M.; Roy, T.; Valdés, J. B.; Lyon, B.; Valdés-Pineda, R.; Serrat-Capdevila, A.; Durcik, M.; Gupta, H.

2017-12-01

The predictability of climate diminishes significantly at shorter time scales (e.g. decadal). Both natural variability as well as sampling variability of climate can obscure or enhance climate change signals in these shorter scales. Therefore, in order to assess the impacts of climate change on basin hydrology, it is important to design climate projections with exhaustive climate scenarios. In this study, we first create seasonal climate scenarios by combining (1) synthetic precipitation projections generated from a Vector Auto-Regressive (VAR) model using the University of East Anglia Climate Research Unit (UEA-CRU) data with (2) seasonal trends calculated from 31 models in the Coupled Model Intercomparison Project Phase 5 (CMIP). The seasonal climate projections are then disaggregated to daily level using the Agricultural Modern-Era Retrospective Analysis for Research and Applications (AgMERRA) data. The daily climate data are then bias-corrected and used as forcings to the land-surface model, Variable Infiltration Capacity (VIC), to generate different hydrological projections for the Mara River basin in East Africa, which are then evaluated to study the hydrologic changes in the basin in the next three decades (2020-2050).

Assessment of simulated water balance from Noah, Noah-MP, CLM, and VIC over CONUS using the NLDAS test bed

DOE Office of Scientific and Technical Information (OSTI.GOV)

Cai, Xitian; Yang, Zong-Liang; Xia, Youlong

2014-12-27

This study assesses the hydrologic performance of four land surface models (LSMs) for the conterminous United States using the North American Land Data Assimilation System (NLDAS) test bed. The four LSMs are the baseline community Noah LSM (Noah, version 2.8), the Variable Infiltration Capacity (VIC, version 4.0.5) model, the substantially augmented Noah LSM with multiparameterization options (hence Noah-MP), and the Community Land Model version 4 (CLM4). All four models are driven by the same NLDAS-2 atmospheric forcing. Modeled terrestrial water storage (TWS), streamflow, evapotranspiration (ET), and soil moisture are compared with each other and evaluated against the identical observations. Relativemore » to Noah, the other three models offer significant improvements in simulating TWS and streamflow and moderate improvements in simulating ET and soil moisture. Noah-MP provides the best performance in simulating soil moisture and is among the best in simulating TWS, CLM4 shows the best performance in simulating ET, and VIC ranks the highest in performing the streamflow simulations. Despite these improvements, CLM4, Noah-MP, and VIC exhibit deficiencies, such as the low variability of soil moisture in CLM4, the fast growth of spring ET in Noah-MP, and the constant overestimation of ET in VIC.« less

Application of a medium-range global hydrologic probabilistic forecast scheme to the Ohio River Basin

DOE Office of Scientific and Technical Information (OSTI.GOV)

Voisin, Nathalie; Pappenberger, Florian; Lettenmaier, D. P.

2011-08-15

A 10-day globally applicable flood prediction scheme was evaluated using the Ohio River basin as a test site for the period 2003-2007. The Variable Infiltration Capacity (VIC) hydrology model was initialized with the European Centre for Medium Range Weather Forecasts (ECMWF) analysis temperatures and wind, and Tropical Rainfall Monitoring Mission Multi Satellite Precipitation Analysis (TMPA) precipitation up to the day of forecast. In forecast mode, the VIC model was then forced with a calibrated and statistically downscaled ECMWF ensemble prediction system (EPS) 10-day ensemble forecast. A parallel set up was used where ECMWF EPS forecasts were interpolated to the spatialmore » scale of the hydrology model. Each set of forecasts was extended by 5 days using monthly mean climatological variables and zero precipitation in order to account for the effect of initial conditions. The 15-day spatially distributed ensemble runoff forecasts were then routed to four locations in the basin, each with different drainage areas. Surrogates for observed daily runoff and flow were provided by the reference run, specifically VIC simulation forced with ECMWF analysis fields and TMPA precipitation fields. The flood prediction scheme using the calibrated and downscaled ECMWF EPS forecasts was shown to be more accurate and reliable than interpolated forecasts for both daily distributed runoff forecasts and daily flow forecasts. Initial and antecedent conditions dominated the flow forecasts for lead times shorter than the time of concentration depending on the flow forecast amounts and the drainage area sizes. The flood prediction scheme had useful skill for the 10 following days at all sites.« less

Spatial expression of components of a calcitonin receptor-like receptor (CRL) signalling system (CRL, calcitonin gene-related peptide, adrenomedullin, adrenomedullin-2/intermedin) in mouse and human heart valves.

PubMed

Pfeil, Uwe; Bharathala, Subhashini; Murtaza, Ghulam; Mermer, Petra; Papadakis, Tamara; Boening, Andreas; Kummer, Wolfgang

2016-12-01

Heart valves are highly organized structures determining the direction of blood flow through the heart. Smooth muscle cells within the valve are thought to play an active role during the heart cycle, rather than being just passive flaps. The mature heart valve is composed of extracellular matrix (ECM), various differentiations of valvular interstitial cells (VIC), smooth muscle cells and overlying endothelium. VIC are important for maintaining the structural integrity of the valve, thereby affecting valve function and ECM remodelling. Accumulating evidence suggests an important role of calcitonin receptor-like receptor (CRL) signalling in preventing heart damage under several pathological conditions. Thus we investigate the existence of a putative CRL signalling system in mouse and human heart valves by real-time RT-PCR, laser-assisted microdissection, immunofluorescence and NADPH-diaphorase histochemistry. Mouse and human heart valves expressed mRNAs for the CRL ligands adrenomedullin (AM), adrenomedullin-2 (AM-2) and calcitonin gene-related peptide (CGRP) and for their receptor components, i.e., CRL and receptor-activity-modifying proteins 1-3. Immunofluorescence analysis revealed AM-, AM-2- and CRL-immunolabelling in endothelial cells and VIC, whereas CGRP immunoreactivity was restricted to nerve fibres and some endothelial cells. Nitric oxide synthase activity, as demonstrated by NADPH-diaphorase histochemistry, was shown mainly in valvular endothelial cells in mice, whereas in human aortic valves, VIC and smooth muscle cells were positive. Our results showed the presence of an intrinsic AM/AM-2/CGRP signalling system in murine and human heart valves with distinct cellular localization, suggesting its involvement in the regulation of valve stiffness and ECM production and turnover.

Increased flood risks in the Sacramento-San Joaquin Valleys, CA, under climate change

NASA Astrophysics Data System (ADS)

Das, T.; Hidalgo-Leon, H.; Dettinger, M.; Cayan, D.

2008-12-01

Natural calamities like floods cause immense damages to human society globally, and California is no exception. A simulation analysis of flood generation in the western Sierra Nevada of California was carried out on simulated by the Variable Infiltration Capacity (VIC) hydrologic model under prescribed changes in precipitation (+10 percent) and temperature (+3oC and +5oC) to evaluate likely changes in 3-day flood- frequency curves under climate change. An additional experiment was carried out where snow production was artificially turned off in VIC. All these experiments showed larger flood magnitudes from California's Northern Sierra Nevada (NSN) and Southern Sierra Nevada (SSN), but the changes (for floods larger than the historical 20-year floods) were significant (at 90 percent confidence level) only in the SSN for severe warming cases. Another analysis using downscaled daily precipitation and temperature projections from three General Circulation Models (CNRM CM3, GFDL CM2.1 and NCAR PCM1) and emission scenario A2 as input to VIC yielded a general increase in the 3-days annual maximum flows under climate change. The increases are significant (at 90 percent confidence level) in the SSN for the period 2051-2099 with all the three climate models analyzed. In the NSN the increases are significant only with the CNRM CM3 model. In general, the frequency of floods increases or stayed same under the projected future climates, and some of the projected floods were unprecedentedly large when compared to historical simulations.

Coupled Surface and Groundwater Hydrological Modeling in a Changing Climate.

PubMed

Sridhar, Venkataramana; Billah, Mirza M; Hildreth, John W

2017-11-09

Many current watershed modeling efforts now incorporate surface water and groundwater for managing water resources since the exchanges between groundwater and surface water need a special focus considering the changing climate. The influence of groundwater dynamics on water and energy balance components is investigated in the Snake River Basin (SRB) by coupling the Variable Infiltration Capacity (VIC) and MODFLOW models (VIC-MF) for the period of 1986 through 2042. A 4.4% increase in base flows and a 10.3% decrease in peak flows are estimated by VIC-MF compared to the VIC model in SRB. The VIC-MF model shows significant improvement in the streamflow simulation (Nash-Sutcliffe efficiency [NSE] of 0.84) at King Hill, where the VIC model could not capture the effect of spring discharge in the streamflow simulation (NSE of -0.30); however, the streamflow estimates show an overall decreasing trend. Two climate scenarios representing median and high radiative-forcings such as representative concentration pathways 4.5 and 8.5 show an average increase in the water table elevations between 2.1 and 2.6 m (6.9 and 8.5 feet) through the year 2042. The spatial patterns of these exchanges show a higher groundwater elevation of 15 m (50 feet) in the downstream area and a lower elevation of up to 3 m (10 feet) in the upstream area. Broadly, this study supports results of previous work demonstrating that integrated assessment of groundwater-surface water enables stakeholders to balance pumping, recharge and base flow needs and to manage the watersheds that are subjected to human pressures more sustainably. © 2017, National Ground Water Association.

Neural signals of vicarious extinction learning

PubMed Central

Haaker, Jan; Selbing, Ida; Olsson, Andreas

2016-01-01

Social transmission of both threat and safety is ubiquitous, but little is known about the neural circuitry underlying vicarious safety learning. This is surprising given that these processes are critical to flexibly adapt to a changeable environment. To address how the expression of previously learned fears can be modified by the transmission of social information, two conditioned stimuli (CS + s) were paired with shock and the third was not. During extinction, we held constant the amount of direct, non-reinforced, exposure to the CSs (i.e. direct extinction), and critically varied whether another individual—acting as a demonstrator—experienced safety (CS + vic safety) or aversive reinforcement (CS + vic reinf). During extinction, ventromedial prefrontal cortex (vmPFC) responses to the CS + vic reinf increased but decreased to the CS + vic safety. This pattern of vmPFC activity was reversed during a subsequent fear reinstatement test, suggesting a temporal shift in the involvement of the vmPFC. Moreover, only the CS + vic reinf association recovered. Our data suggest that vicarious extinction prevents the return of conditioned fear responses, and that this efficacy is reflected by diminished vmPFC involvement during extinction learning. The present findings may have important implications for understanding how social information influences the persistence of fear memories in individuals suffering from emotional disorders. PMID:27278792

Regulation of a Viral Proteinase by a Peptide and DNA in One-dimensional Space

PubMed Central

Blainey, Paul C.; Graziano, Vito; Pérez-Berná, Ana J.; McGrath, William J.; Flint, S. Jane; San Martín, Carmen; Xie, X. Sunney; Mangel, Walter F.

2013-01-01

Precursor proteins used in the assembly of adenovirus virions must be processed by the virally encoded adenovirus proteinase (AVP) before the virus particle becomes infectious. An activated adenovirus proteinase, the AVP-pVIc complex, was shown to slide along viral DNA with an extremely fast one-dimensional diffusion constant, 21.0 ± 1.9 × 106 bp2/s. In principle, one-dimensional diffusion can provide a means for DNA-bound proteinases to locate and process DNA-bound substrates. Here, we show that this is correct. In vitro, AVP-pVIc complexes processed a purified virion precursor protein in a DNA-dependent reaction; in a quasi in vivo environment, heat-disrupted ts-1 virions, AVP-pVIc complexes processed five different precursor proteins in DNA-dependent reactions. Sliding of AVP-pVIc complexes along DNA illustrates a new biochemical mechanism by which a proteinase can locate its substrates, represents a new paradigm for virion maturation, and reveals a new way of exploiting the surface of DNA. PMID:23043138

VIC-CropSyst-v2: A regional-scale modeling platform to simulate the nexus of climate, hydrology, cropping systems, and human decisions

NASA Astrophysics Data System (ADS)

Malek, Keyvan; Stöckle, Claudio; Chinnayakanahalli, Kiran; Nelson, Roger; Liu, Mingliang; Rajagopalan, Kirti; Barik, Muhammad; Adam, Jennifer C.

2017-08-01

Food supply is affected by a complex nexus of land, atmosphere, and human processes, including short- and long-term stressors (e.g., drought and climate change, respectively). A simulation platform that captures these complex elements can be used to inform policy and best management practices to promote sustainable agriculture. We have developed a tightly coupled framework using the macroscale variable infiltration capacity (VIC) hydrologic model and the CropSyst agricultural model. A mechanistic irrigation module was also developed for inclusion in this framework. Because VIC-CropSyst combines two widely used and mechanistic models (for crop phenology, growth, management, and macroscale hydrology), it can provide realistic and hydrologically consistent simulations of water availability, crop water requirements for irrigation, and agricultural productivity for both irrigated and dryland systems. This allows VIC-CropSyst to provide managers and decision makers with reliable information on regional water stresses and their impacts on food production. Additionally, VIC-CropSyst is being used in conjunction with socioeconomic models, river system models, and atmospheric models to simulate feedback processes between regional water availability, agricultural water management decisions, and land-atmosphere interactions. The performance of VIC-CropSyst was evaluated on both regional (over the US Pacific Northwest) and point scales. Point-scale evaluation involved using two flux tower sites located in agricultural fields in the US (Nebraska and Illinois). The agreement between recorded and simulated evapotranspiration (ET), applied irrigation water, soil moisture, leaf area index (LAI), and yield indicated that, although the model is intended to work on regional scales, it also captures field-scale processes in agricultural areas.

Side-Specific Endothelial-Dependent Regulation of Aortic Valve Calcification

PubMed Central

Richards, Jennifer; El-Hamamsy, Ismail; Chen, Si; Sarang, Zubair; Sarathchandra, Padmini; Yacoub, Magdi H.; Chester, Adrian H.; Butcher, Jonathan T.

2014-01-01

Arterial endothelial cells maintain vascular homeostasis and vessel tone in part through the secretion of nitric oxide (NO). In this study, we determined how aortic valve endothelial cells (VEC) regulate aortic valve interstitial cell (VIC) phenotype and matrix calcification through NO. Using an anchored in vitro collagen hydrogel culture system, we demonstrate that three-dimensionally cultured porcine VIC do not calcify in osteogenic medium unless under mechanical stress. Co-culture with porcine VEC, however, significantly attenuated VIC calcification through inhibition of myofibroblastic activation, osteogenic differentiation, and calcium deposition. Incubation with the NO donor DETA-NO inhibited VIC osteogenic differentiation and matrix calcification, whereas incubation with the NO blocker l-NAME augmented calcification even in 3D VIC–VEC co-culture. Aortic VEC, but not VIC, expressed endothelial NO synthase (eNOS) in both porcine and human valves, which was reduced in osteogenic medium. eNOS expression was reduced in calcified human aortic valves in a side-specific manner. Porcine leaflets exposed to the soluble guanylyl cyclase inhibitor ODQ increased osteocalcin and α-smooth muscle actin expression. Finally, side-specific shear stress applied to porcine aortic valve leaflet endothelial surfaces increased cGMP production in VEC. Valve endothelial-derived NO is a natural inhibitor of the early phases of valve calcification and therefore may be an important regulator of valve homeostasis and pathology. PMID:23499458

Intake and transformation to a glycoside of (Z)-3-hexenol from infested neighbors reveals a mode of plant odor reception and defense

PubMed Central

Sugimoto, Koichi; Matsui, Kenji; Iijima, Yoko; Akakabe, Yoshihiko; Muramoto, Shoko; Ozawa, Rika; Uefune, Masayoshi; Sasaki, Ryosuke; Alamgir, Kabir Md.; Akitake, Shota; Nobuke, Tatsunori; Galis, Ivan; Aoki, Koh; Shibata, Daisuke; Takabayashi, Junji

2014-01-01

Plants receive volatile compounds emitted by neighboring plants that are infested by herbivores, and consequently the receiver plants begin to defend against forthcoming herbivory. However, to date, how plants receive volatiles and, consequently, how they fortify their defenses, is largely unknown. In this study, we found that undamaged tomato plants exposed to volatiles emitted by conspecifics infested with common cutworms (exposed plants) became more defensive against the larvae than those exposed to volatiles from uninfested conspecifics (control plants) in a constant airflow system under laboratory conditions. Comprehensive metabolite analyses showed that only the amount of (Z)-3-hexenylvicianoside (HexVic) was higher in exposed than control plants. This compound negatively affected the performance of common cutworms when added to an artificial diet. The aglycon of HexVic, (Z)-3-hexenol, was obtained from neighboring infested plants via the air. The amount of jasmonates (JAs) was not higher in exposed plants, and HexVic biosynthesis was independent of JA signaling. The use of (Z)-3-hexenol from neighboring damaged conspecifics for HexVic biosynthesis in exposed plants was also observed in an experimental field, indicating that (Z)-3-hexenol intake occurred even under fluctuating environmental conditions. Specific use of airborne (Z)-3-hexenol to form HexVic in undamaged tomato plants reveals a previously unidentified mechanism of plant defense. PMID:24778218

78. GUN RILL STATION (VIC. 210TH STREET) GENERAL VIEW SOUTH ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

78. GUN RILL STATION (VIC. 210TH STREET) GENERAL VIEW SOUTH ON NORTHBOUND TRACK SHOWING SIGNAL & CONTROL. - Interborough Rapid Transit Company, Third Avenue Elevated Line, Borough of the Bronx, New York County, NY

Integration of multispectral and SAR data for monitoring forest ecosystems recovery after fire

NASA Astrophysics Data System (ADS)

Stankova, Nataliya; Nedkov, Roumen; Ivanova, Iva; Avetisyan, Daniela

2017-09-01

The aim of this study is assessing the impacts and monitoring the condition and recovery processes of forest ecosystems after fire based on remote aerospace methods and data. To achieve this goal, satellite imagery in microwave and optical range of the spectrum were used. A hybrid model for assessing the instantaneous condition of forest ecosystems after fire that uses parallel data from optical and Synthetic Aperture Radar (SAR) was developed. Based on the three Tasseled Cap components (Brightness-BR, Greenness-GR and Wetness-W), a vector describing the current condition of the forest ecosystems was obtained and used as input data from the optical range. Results obtained by implementation of the proposed approach show that the integrated composite images of VIC and SAR represent the degree of recovery.

Development of South Australian-Victorian Prostate Cancer Health Outcomes Research Dataset.

PubMed

Ruseckaite, Rasa; Beckmann, Kerri; O'Callaghan, Michael; Roder, David; Moretti, Kim; Zalcberg, John; Millar, Jeremy; Evans, Sue

2016-01-22

Prostate cancer is the most commonly diagnosed and prevalent malignancy reported to Australian cancer registries, with numerous studies from single institutions summarizing patient outcomes at individual hospitals or States. In order to provide an overview of patterns of care of men with prostate cancer across multiple institutions in Australia, a specialized dataset was developed. This dataset, containing amalgamated data from South Australian and Victorian prostate cancer registries, is called the South Australian-Victorian Prostate Cancer Health Outcomes Research Dataset (SA-VIC PCHORD). A total of 13,598 de-identified records of men with prostate cancer diagnosed and consented between 2008 and 2013 in South Australia and Victoria were merged into the SA-VIC PCHORD. SA-VIC PCHORD contains detailed information about socio-demographic, diagnostic and treatment characteristics of patients with prostate cancer in South Australia and Victoria. Data from individual registries are available to researchers and can be accessed under individual data access policies in each State. The SA-VIC PCHORD will be used for numerous studies summarizing trends in diagnostic characteristics, survival and patterns of care in men with prostate cancer in Victoria and South Australia. It is expected that in the future the SA-VIC PCHORD will become a principal component of the recently developed bi-national Australian and New Zealand Prostate Cancer Outcomes Registry to collect and report patterns of care and standardised patient reported outcome measures of men nation-wide in Australia and New Zealand.

Decriminalisation of abortion performed by qualified health practitioners under the Abortion Law Reform Act 2008 (Vic).

PubMed

Mendelson, Danuta

2012-06-01

In 2008, the Victorian Parliament enacted the Abortion Law Reform Act 2008 (Vic) and amended the Crimes Act 1958 (Vic) to decriminalise terminations of pregnancy while making it a criminal offence for unqualified persons to carry out such procedures. The reform legislation has imposed a civil regulatory regime on the management of abortions, and has stipulated particular statutory duties of care for registered qualified health care practitioners who have conscientious objections to terminations of pregnancy. The background to, and the structure of, this novel statutory regime is examined, with a focus on conscientious objection clauses and liability in the tort of negligence and the tort of breach of statutory duty.

Crystal structure of the human adenovirus proteinase with its 11 amino acid cofactor.

PubMed Central

Ding, J; McGrath, W J; Sweet, R M; Mangel, W F

1996-01-01

The three-dimensional structure of the human adenovirus-2 proteinase complexed with its 11 amino acid cofactor, pVIc, was determined at 2.6 A resolution by X-ray crystallographic analysis. The fold of this protein has not been seen before. However, it represents an example of either subtly divergent or powerfully convergent evolution, because the active site contains a Cys-His-Glu triplet and oxyanion hole in an arrangement similar to that in papain. Thus, the adenovirus proteinase represents a new, fifth group of enzymes that contain catalytic triads. pVIc, which extends a beta-sheet in the main chain, is distant from the active site, yet its binding increases the catalytic rate constant 300-fold for substrate hydrolysis. The structure reveals several potential targets for antiviral therapy. Images PMID:8617222

Dense velocity reconstruction from tomographic PTV with material derivatives

NASA Astrophysics Data System (ADS)

Schneiders, Jan F. G.; Scarano, Fulvio

2016-09-01

A method is proposed to reconstruct the instantaneous velocity field from time-resolved volumetric particle tracking velocimetry (PTV, e.g., 3D-PTV, tomographic PTV and Shake-the-Box), employing both the instantaneous velocity and the velocity material derivative of the sparse tracer particles. The constraint to the measured temporal derivative of the PTV particle tracks improves the consistency of the reconstructed velocity field. The method is christened as pouring time into space, as it leverages temporal information to increase the spatial resolution of volumetric PTV measurements. This approach becomes relevant in cases where the spatial resolution is limited by the seeding concentration. The method solves an optimization problem to find the vorticity and velocity fields that minimize a cost function, which includes next to instantaneous velocity, also the velocity material derivative. The velocity and its material derivative are related through the vorticity transport equation, and the cost function is minimized using the limited-memory Broyden-Fletcher-Goldfarb-Shanno (L-BFGS) algorithm. The procedure is assessed numerically with a simulated PTV experiment in a turbulent boundary layer from a direct numerical simulation (DNS). The experimental validation considers a tomographic particle image velocimetry (PIV) experiment in a similar turbulent boundary layer and the additional case of a jet flow. The proposed technique (`vortex-in-cell plus', VIC+) is compared to tomographic PIV analysis (3D iterative cross-correlation), PTV interpolation methods (linear and adaptive Gaussian windowing) and to vortex-in-cell (VIC) interpolation without the material derivative. A visible increase in resolved details in the turbulent structures is obtained with the VIC+ approach, both in numerical simulations and experiments. This results in a more accurate determination of the turbulent stresses distribution in turbulent boundary layer investigations. Data from a jet experiment, where the vortex topology is retrieved with a small number of tracers indicate the potential utilization of VIC+ in low-concentration experiments as for instance occurring in large-scale volumetric PTV measurements.

Vic Goes to Near Space

ERIC Educational Resources Information Center

Merhar, Vida Kariž; Capuder, Rok; Maroševic, Timotej; Artac, Sonja; Mozer, Alenka; Štekovic, Maja

2016-01-01

In the school year 2012-2013 about 50 students (Fig. 1), managed by mentors (teachers from the middle school Gimnazija Vic in Ljubljana, Slovenia) created an atmospheric probe and launched it into an altitude of more than 30 km above Earth's surface. The aim of this "space expedition" was to take pictures of Earth and to measure how air…

A variant of Leber hereditary optic neuropathy characterized by recovery of vision and by an unusual mitochondrial genetic etiology.

PubMed Central

Mackey, D; Howell, N

1992-01-01

The Tas2 and Vic2 Australian families are affected with a variant of Leber hereditary optic neuropathy (LHON). The risk of developing the optic neuropathy shows strict maternal inheritance, and the ophthalmological changes in affected family members are characteristic of LHON. However, in contrast to the common form of the disease, members of these two families show a high frequency of vision recovery. To ascertain the mitochondrial genetic etiology of the LHON in these families, both (a) the the nucleotide sequences of the seven mitochondrial genes encoding subunits of respiratory-chain complex I and (b) the mitochondrial cytochrome b gene were determined for representatives of both families. Neither family carries any of the previously identified primary mitochondrial LHON mutations: ND4/11778, ND1/3460, or ND1/4160. Instead, both LHON families carry multiple nucleotide changes in the mitochondrial complex I genes, which produce conservative amino acid changes. From the available sequence data, it is inferred that the Vic2 and Tas2 LHON families are phylogenetically related to each other and to a cluster of LHON families in which mutations in the mitochondrial cytochrome b gene have been hypothesized to play a primary etiological role. However, sequencing analysis establishes that the Vic2 and Tas2 LHON families do not carry these cytochrome b mutations. There are two hypotheses to account for the unusual mitochondrial genetic etiology of the LHON in the Tas2 and Vic2 LHON families. One possibility is that there is a primary LHON mutation within the mitochondrial genome but that it is at a site that was not included in the sequencing analyses. Alternatively, the disease in these families may result from the cumulative effects of multiple secondary LHON mutations that have less severe phenotypic consequences. PMID:1463007

A variant of Leber hereditary optic neuropathy characterized by recovery of vision and by an unusual mitochondrial genetic etiology

DOE Office of Scientific and Technical Information (OSTI.GOV)

Mackey, D.; Howell, N.

1992-12-01

The Tas2 and Vic2 Australian families are affected with a variant of Leber hereditary optic neuropathy (LHON). The risk of developing the optic neuropathy shows strict maternal inheritance, and the opthalmological changes in affected family members are characteristic of LHON. However, in contrast to the common form of the disease, members of these two families show a high frequency of vision recovery. To ascertain the mitochondrial genetic etiology of the LHON in these families, both (a) the nucleotide sequences of the seven mitochondrial genes encoding subunits of respiratory-chain complex I and (b) the mitochondrial cytochrome b gene were determined formore » representatives of both families. Neither family carries any of the previously identified primary mitochondrial LHON mutations: ND4/11778, ND1/3460, or ND1/4160. Instead, both LHON families carry multiple nucleotide changes in the mitochondrial complex I genes, which produce conservative amino acid changes. From the available sequence data, it is inferred that the Vic2 and Tas2 LHON families are phylogenetically related to each other and to a cluster of LHON families in which mutations in the mitochondrial cytochrome b gene have been hypothesized to play a primary etiological role. However, sequencing analysis establishes that the Vic2 and Tas2 LHON families do not carry these cytochrome b mutations. There are two hypotheses to account for the unusual mitochondrial genetic etiology of the LHON in the Tas2 and Vic2 LHON families. One possibility is that there is a primary LHON mutation within the mitochondrial genome but that it is at a site that was not included in the sequencing analyses. Alternatively, the disease in these families may result from the cumulative effects of multiple secondary LHON mutations that have less severe phenotypic consequences. 29 refs., 3 figs., 3 tabs.« less

Future Climate Change Impacts on Surface Hydrology over Texas River Basins

NASA Astrophysics Data System (ADS)

Lee, K.; Gao, H.; Huang, M.; Sheffield, J.

2014-12-01

Future freshwater availability is a pressing issue in Texas due to frequent drought events and fast population growth. Even though the science community has well investigated future temperature trends, it is still unclear whether precipitation will increase or decrease in this region. Furthermore, there is a lack of understanding on how the changing climate will affect water resources across different spatial-temporal scales. This study aims to quantify the impacts of climate change on surface hydrology at the basin scale under different future emission scenarios. The Variable Infiltration Capacity (VIC) model, forced by an ensemble of statistically downscaled climate projections from the Coupled Model Intercomparison Project Phase 5 (CMIP5) models, is employed to predict the future hydrology. The VIC model parameters are adopted from the North American Land Data Assimilation System (NLDAS) at a spatial resolution of 1/8°. The CMIP5 projections contain four different scenarios in terms of Representative Concentration Pathway (RCP) (i.e. 2.6, 4.5, 6.0 and 8.5 w/m2). The analysis is carried out in three steps. First, the observed streamflows are used to evaluate the performance of VIC simulations forced by CMIP5 models during historical period. Second, VIC outputs under multiple CMIP5 model scenarios from 1950 to 2099 are analyzed to identify how soil moisture, evapotranspiration, runoff, and routed streamflows change in time and space. Third, the spatial patterns of seasonal temperature, seasonal precipitation, and the Palmer Drought Severity Index (PDSI)—over four 20-year periods (1980-1999, 2010-2029, 2040-2059 and 2080-2099)—are used to pinpoint the regions that will be most affected by climate change (among the 13 Texan river basins). Furthermore, the role of groundwater in meeting the increasing needs for water supply is discussed. The results are expected to contribute to various future water resources management decisions in Texas.

Whole-Genome Phylogenetic Analysis of Influenza B/Phuket/3073/2013-Like Viruses and Unique Reassortants Detected in Malaysia between 2012 and 2014

PubMed Central

Tan, Joon Ling; Chan, Kok Gan; Kamarulzaman, Adeeba; Chan, Yoke Fun; Sam, I-Ching; Tee, Kok Keng

2017-01-01

Reassortment of genetic segments between and within influenza B lineages (Victoria and Yamagata) has been shown to generate novel reassortants with unique genetic characteristics. Based on hemagglutinin (HA) and neuraminidase (NA) genes, recent surveillance study has identified reassortment properties in B/Phuket/3073/2013-like virus, which is currently used in the WHO-recommended influenza vaccine. To understand the potential reassortment patterns for all gene segments, four B/Phuket/3073/2013-like viruses and two unique reassortants (one each from Yamagata and Victoria) detected in Malaysia from 2012–2014 were subjected to whole-genome sequencing. Each gene was phylogenetically classified into lineages, clades and sub-clades. Three B/Phuket/3073/2013-like viruses from Yamagata lineage were found to be intra-clade reassortants, possessing PA and NA genes derived from Stockholm/12-like sub-clade, while the remaining genes from Wisconsin/01-like sub-clade (both sub-clades were within Yamagata Clade 3/Yam-3). However, the other B/Phuket/3073/2013-like virus had NS gene that derived from Stockholm/12-like sub-clade instead of Wisconsin/01-like sub-clade. One inter-clade reassortant had Yamagata Clade 2/Yam-2-derived HA and NP, and its remaining genes were Yam-3-derived. Within Victoria Clade 1/Vic-1 in Victoria lineage, one virus had intra-clade reassortment properties: HA and PB2 from Vic-1B sub-clade, MP and NS from a unique sub-clade “Vic-1C”, and the remaining genes from Vic-1A sub-clade. Although random reassortment event may generate unique reassortants, detailed phylogenetic classification of gene segments showed possible genetic linkage between PA and NA genes in B/Phuket/3073/2013-like viruses, which requires further investigation. Understanding on reassortment patterns in influenza B evolution may contribute to future vaccine design. PMID:28129386

Combining Dynamic Stretch and Tunable Stiffness to Probe Cell Mechanobiology In Vitro

PubMed Central

Throm Quinlan, Angela M.; Sierad, Leslie N.; Capulli, Andrew K.; Firstenberg, Laura E.; Billiar, Kristen L.

2011-01-01

Cells have the ability to actively sense their mechanical environment and respond to both substrate stiffness and stretch by altering their adhesion, proliferation, locomotion, morphology, and synthetic profile. In order to elucidate the interrelated effects of different mechanical stimuli on cell phenotype in vitro, we have developed a method for culturing mammalian cells in a two-dimensional environment at a wide range of combined levels of substrate stiffness and dynamic stretch. Polyacrylamide gels were covalently bonded to flexible silicone culture plates and coated with monomeric collagen for cell adhesion. Substrate stiffness was adjusted from relatively soft (G′ = 0.3 kPa) to stiff (G′ = 50 kPa) by altering the ratio of acrylamide to bis-acrylamide, and the silicone membranes were stretched over circular loading posts by applying vacuum pressure to impart near-uniform stretch, as confirmed by strain field analysis. As a demonstration of the system, porcine aortic valve interstitial cells (VIC) and human mesenchymal stem cells (hMSC) were plated on soft and stiff substrates either statically cultured or exposed to 10% equibiaxial or pure uniaxial stretch at 1Hz for 6 hours. In all cases, cell attachment and cell viability were high. On soft substrates, VICs cultured statically exhibit a small rounded morphology, significantly smaller than on stiff substrates (p<0.05). Following equibiaxial cyclic stretch, VICs spread to the extent of cells cultured on stiff substrates, but did not reorient in response to uniaxial stretch to the extent of cells stretched on stiff substrates. hMSCs exhibited a less pronounced response than VICs, likely due to a lower stiffness threshold for spreading on static gels. These preliminary data demonstrate that inhibition of spreading due to a lack of matrix stiffness surrounding a cell may be overcome by externally applied stretch suggesting similar mechanotransduction mechanisms for sensing stiffness and stretch. PMID:21858051

Control theory analysis of a three-axis VTOL flight director. M.S. Thesis - Pennsylvania State Univ.

NASA Technical Reports Server (NTRS)

Niessen, F. R.

1971-01-01

A control theory analysis of a VTOL flight director and the results of a fixed-based simulator evaluation of the flight-director commands are discussed. The VTOL configuration selected for this study is a helicopter-type VTOL which controls the direction of the thrust vector by means of vehicle-attitude changes and, furthermore, employs high-gain attitude stabilization. This configuration is the same as one which was simulated in actual instrument flight tests with a variable stability helicopter. Stability analyses are made for each of the flight-director commands, assuming a single input-output, multi-loop system model for each control axis. The analyses proceed from the inner-loops to the outer-loops, using an analytical pilot model selected on the basis of the innermost-loop dynamics. The time response of the analytical model of the system is primarily used to adjust system gains, while root locus plots are used to identify dominant modes and mode interactions.

Fibroblast growth factor represses Smad-mediated myofibroblast activation in aortic valvular interstitial cells

PubMed Central

Cushing, Melinda C.; Mariner, Peter D.; Liao, Jo-Tsu; Sims, Evan A.; Anseth, Kristi S.

2008-01-01

This study aimed to identify signaling pathways that oppose connective tissue fibrosis in the aortic valve. Using valvular interstitial cells (VICs) isolated from porcine aortic valve leaflets, we show that basic fibroblast growth factor (FGF-2) effectively blocks transforming growth factor-β1 (TGF-β1)-mediated myofibroblast activation. FGF-2 prevents the induction of α-smooth muscle actin (αSMA) expression and the exit of VICs from the cell cycle, both of which are hallmarks of myofibroblast activation. By blocking the activity of the Smad transcription factors that serve as the downstream nuclear effectors of TGF-β1, FGF-2 treatment inhibits fibrosis in VICs. Using an exogenous Smad-responsive transcriptional promoter reporter, we show that Smad activity is repressed by FGF-2, likely an effect of the fact that FGF-2 treatment prevents the nuclear localization of Smads in these cells. This appears to be a direct effect of FGF signaling through mitogen-activated protein kinase (MAPK) cascades as the treatment of VICs with the MAPK/extracellular regulated kinase (MEK) inhibitor U0126 acted to induce fibrosis and blocked the ability of FGF-2 to inhibit TGF-β1 signaling. Furthermore, FGF-2 treatment of VICs blocks the development of pathological contractile and calcifying phenotypes, suggesting that these pathways may be utilized in the engineering of effective treatments for valvular disease.—Cushing, M. C., Mariner, P. D., Liao, J. T., Sims, E. A., Anseth, K. S. Fibroblast growth factor represses Smad-mediated myofibroblast activation in aortic valvular interstitial cells. PMID:18218921

Directory of Manufacturing Research Centers

DTIC Science & Technology

1989-06-01

Martin W. 51 Graff, Karl 176 Dornfeld, David 88 Gray, James 76 Doty, Keith 119 Gray, Vic 6 Driels, Morris 142 Green Jr., Robert E. 51 Drury , Colin 39...Buffalo Dr. Colin Drury , Executive Director Mr. Brian Kleiner, Administrative Director Technical areas include cost analysis, strategic planning

Vic: The Challenges Facing Schools in a Small, Newly Diverse, Catalan City

ERIC Educational Resources Information Center

Simo, Nuria; Telford, Jon

2012-01-01

The arrival over the last 15 years of a substantial number of pupils of immigrant origin has presented Catalan schools with significant challenges. The schools in Vic (70 km north of Barcelona) have been at the forefront of attempts to adjust to this new multicultural reality. This article describes the results of three studies carried out by the…

A user-friendly software package to ease the use of VIC hydrologic model for practitioners

NASA Astrophysics Data System (ADS)

Wi, S.; Ray, P.; Brown, C.

2016-12-01

The VIC (Variable Infiltration Capacity) hydrologic and river routing model simulates the water and energy fluxes that occur near the land surface and provides users with useful information regarding the quantity and timing of available water at points of interest within the basin. However, despite its popularity (proved by numerous applications in the literature), its wider adoption is hampered by the considerable effort required to prepare model inputs; e.g., input files storing spatial information related to watershed topography, soil properties, and land cover. This study presents a user-friendly software package (named VIC Setup Toolkit) developed within the MATLAB (matrix laboratory) framework and accessible through an intuitive graphical user interface. The VIC Setup Toolkit enables users to navigate the model building process confidently through prompts and automation, with an intention to promote the use of the model for both practical and academic purposes. The automated processes include watershed delineation, climate and geographical input set-up, model parameter calibration, graph generation and output evaluation. We demonstrate the package's usefulness in various case studies with the American River, Oklahoma River, Feather River and Zambezi River basins.

Bayesian analysis of input uncertainty in hydrological modeling: 2. Application

NASA Astrophysics Data System (ADS)

Kavetski, Dmitri; Kuczera, George; Franks, Stewart W.

2006-03-01

The Bayesian total error analysis (BATEA) methodology directly addresses both input and output errors in hydrological modeling, requiring the modeler to make explicit, rather than implicit, assumptions about the likely extent of data uncertainty. This study considers a BATEA assessment of two North American catchments: (1) French Broad River and (2) Potomac basins. It assesses the performance of the conceptual Variable Infiltration Capacity (VIC) model with and without accounting for input (precipitation) uncertainty. The results show the considerable effects of precipitation errors on the predicted hydrographs (especially the prediction limits) and on the calibrated parameters. In addition, the performance of BATEA in the presence of severe model errors is analyzed. While BATEA allows a very direct treatment of input uncertainty and yields some limited insight into model errors, it requires the specification of valid error models, which are currently poorly understood and require further work. Moreover, it leads to computationally challenging highly dimensional problems. For some types of models, including the VIC implemented using robust numerical methods, the computational cost of BATEA can be reduced using Newton-type methods.

Interactive Spectral Analysis and Computation (ISAAC)

NASA Technical Reports Server (NTRS)

Lytle, D. M.

1992-01-01

Isaac is a task in the NSO external package for IRAF. A descendant of a FORTRAN program written to analyze data from a Fourier transform spectrometer, the current implementation has been generalized sufficiently to make it useful for general spectral analysis and other one dimensional data analysis tasks. The user interface for Isaac is implemented as an interpreted mini-language containing a powerful, programmable vector calculator. Built-in commands provide much of the functionality needed to produce accurate line lists from input spectra. These built-in functions include automated spectral line finding, least squares fitting of Voigt profiles to spectral lines including equality constraints, various filters including an optimal filter construction tool, continuum fitting, and various I/O functions.

Markers linked to vegetative incompatibility (vic) genes and a region of high heterogeneity and reduced recombination near the mating type locus (MAT) in Cryphonectria parasitica

Treesearch

Thomas L. Kubisiak; Michael g. Milgroom

2006-01-01

To find markers linked to vegetative incompatibility (vic) genes in the chestnut blight fungus, Cryphonectria parasitica, we constructed a preliminary linkage map. In general, this map is characterized by low levels of polymorphism, as evident from the more than 24 linkage groups observed, compared to seven expected from electrophoretic karyotyping....

Immunogenicity and safety of a quadrivalent inactivated influenza vaccine compared with two trivalent inactivated influenza vaccines containing alternate B strains in adults: A phase 3, randomized noninferiority study.

PubMed

Treanor, John T; Albano, Frank R; Sawlwin, Daphne C; Graves Jones, Alison; Airey, Jolanta; Formica, Neil; Matassa, Vince; Leong, Jane

2017-04-04

Vaccination is the most effective means of influenza prevention. Efficacy of trivalent vaccines may be enhanced by including both B strain lineages. This phase 3, double-blind study assessed the immunogenicity and safety/tolerability of a quadrivalent inactivated influenza vaccine (IIV4) versus the United States (US)-licensed 2014-2015 trivalent inactivated influenza vaccine (IIV3-Yamagata [IIV3-YAM]; Afluria) and IIV3 containing the alternate Victoria B strain (IIV3-VIC) in adults ≥18years. Participants (n=3484) were randomized 2:1:1 and stratified by age to receive IIV4 (n=1741), IIV3-YAM (n=871), or IIV3-VIC (n=872). The primary objective was to demonstrate noninferiority of the immunological response to IIV4 versus IIV3-YAM and IIV3-VIC. Noninferiority was assessed by hemagglutination inhibition geometric mean titer (GMT) ratio (IIV3/IIV4; upper bound of two-sided 95% confidence interval [CI]≤1.5) and seroconversion rate (SCR) difference (IIV3 - IIV4; upper bound of two-sided 95% CI≤10%) for vaccine strains. Solicited local and systemic adverse events (AEs) were assessed for 7days postvaccination, AEs recorded for 28days postvaccination, and serious AEs for 6months postvaccination. IIV4 elicited a noninferior immune response for matched strains, and superior response for unmatched B strains not contained in IIV3 comparators. Adjusted GMT ratios (95% CI) for A/H1N1, A/H3N2, B/YAM, and B/VIC strains were 0.93 (0.88, 0.99), 0.93 (0.88, 0.98), 0.87 (IIV3-YAM; 0.82, 0.93), and 0.95 (IIV3-VIC; 0.88, 1.03), respectively. Corresponding values for SCR differences (95% CI) were -1.1 (-4.5, 2.3), -1.7 (-5.0, 1.7), -3.2 (IIV3-YAM; -7.4, 0.9), and -1.6 (IIV3-VIC; -5.8, 2.5). AEs were generally mild and experienced by 52.9% of participants. Serious AEs were reported with a slightly higher frequency with IIV4 (2.3%) versus IIV3-YAM (1.6%) and IIV3-VIC (1.5%). IIV4 demonstrated immunological noninferiority to the US-licensed IIV3, and superiority for unmatched B strains not contained in IIV3 comparators. Safety/tolerability profiles were similar across vaccine groups. Seqirus; Clinicaltrials.gov: NCT02214225. Copyright © 2017. Published by Elsevier Ltd.

Palliative sedation: reliability and validity of sedation scales.

PubMed

Arevalo, Jimmy J; Brinkkemper, Tijn; van der Heide, Agnes; Rietjens, Judith A; Ribbe, Miel; Deliens, Luc; Loer, Stephan A; Zuurmond, Wouter W A; Perez, Roberto S G M

2012-11-01

Observer-based sedation scales have been used to provide a measurable estimate of the comfort of nonalert patients in palliative sedation. However, their usefulness and appropriateness in this setting has not been demonstrated. To study the reliability and validity of observer-based sedation scales in palliative sedation. A prospective evaluation of 54 patients under intermittent or continuous sedation with four sedation scales was performed by 52 nurses. Included scales were the Minnesota Sedation Assessment Tool (MSAT), Richmond Agitation-Sedation Scale (RASS), Vancouver Interaction and Calmness Scale (VICS), and a sedation score proposed in the Guideline for Palliative Sedation of the Royal Dutch Medical Association (KNMG). Inter-rater reliability was tested with the intraclass correlation coefficient (ICC) and Cohen's kappa coefficient. Correlations between the scales using Spearman's rho tested concurrent validity. We also examined construct, discriminative, and evaluative validity. In addition, nurses completed a user-friendliness survey. Overall moderate to high inter-rater reliability was found for the VICS interaction subscale (ICC = 0.85), RASS (ICC = 0.73), and KNMG (ICC = 0.71). The largest correlation between scales was found for the RASS and KNMG (rho = 0.836). All scales showed discriminative and evaluative validity, except for the MSAT motor subscale and VICS calmness subscale. Finally, the RASS was less time consuming, clearer, and easier to use than the MSAT and VICS. The RASS and KNMG scales stand as the most reliable and valid among the evaluated scales. In addition, the RASS was less time consuming, clearer, and easier to use than the MSAT and VICS. Further research is needed to evaluate the impact of the scales on better symptom control and patient comfort. Copyright © 2012 U.S. Cancer Pain Relief Committee. Published by Elsevier Inc. All rights reserved.

Online virtual cases to teach resource stewardship.

PubMed

Zhou, Linghong Linda; Tait, Gordon; Sandhu, Sharron; Steiman, Amanda; Lake, Shirley

2018-06-11

As health care costs rise, medical education must focus on high-value clinical decision making. To teach and assess efficient resource use in rheumatology, online virtual interactive cases (VICs) were developed to simulate real patient encounters to increase price transparency and reinforce cost consciousness. To teach and assess efficient resource use in rheumatology, online virtual interactive cases (VICs) were developed METHODS: The VIC modules were distributed to a sample of medical students and internal medicine residents, who were required to assess patients, order appropriate investigations, develop differential diagnoses and formulate management plans. Each action was associated with a time and price, with the totals compared against ideals. Trainees were evaluated not only on their diagnosis and patient management, but also on the total time, cost and value of their selected workup. Trainee responses were tracked anonymously, with opportunity to provide feedback at the end of each case. Seventeen medical trainees completed a total of 48 VIC modules. On average, trainees spent CAN $227.52 and 68 virtual minutes on each case, which was lower than expected. This may have been the result of a low management score of 52.4%, although on average 92.0% of participants in each case achieved the correct diagnosis. In addition, 85.7% felt more comfortable working up similar cases, and 57.1% believed that the modules increased their ability to appropriately order cost-conscious rheumatology investigations. Our initial assessment of the VIC rheumatology modules was positive, supporting their role as an effective tool in teaching an approach to rheumatology patients, with an emphasis on resource stewardship. Future directions include the expansion of cases, based on feedback, wider dissemination and an evaluation of learning retention. © 2018 John Wiley & Sons Ltd and The Association for the Study of Medical Education.

U.S. Army Toxic Metal Reduction Program: Demonstrating Alternatives to Hexavalent Chromium and Cadmium in Surface Finishing

DTIC Science & Technology

2014-11-18

only) Medium Cal: M242 25mm Bushmaster, M230 30mm, GAU-12 25mm, 30mm Bushmaster II, EAPS 50mm POC: Vic Champagne , ARL, victor.k.champagne.civ...Shielding for Electronic Shelters) POC: Vic Champagne , ARL, victor.k.champagne.civ@mail.mil Cold Spray – Portable System and Internal Diameter

Streamflow simulation for continental-scale river basins

NASA Astrophysics Data System (ADS)

Nijssen, Bart; Lettenmaier, Dennis P.; Liang, Xu; Wetzel, Suzanne W.; Wood, Eric F.

1997-04-01

A grid network version of the two-layer variable infiltration capacity (VIC-2L) macroscale hydrologic model is described. VIC-2L is a hydrologically based soil- vegetation-atmosphere transfer scheme designed to represent the land surface in numerical weather prediction and climate models. The grid network scheme allows streamflow to be predicted for large continental rivers. Off-line (observed and estimated surface meteorological and radiative forcings) applications of the model to the Columbia River (1° latitude-longitude spatial resolution) and Delaware River (0.5° resolution) are described. The model performed quite well in both applications, reproducing the seasonal hydrograph and annual flow volumes to within a few percent. Difficulties in reproducing observed streamflow in the arid portion of the Snake River basin are attributed to groundwater-surface water interactions, which are not modeled by VIC-2L.

VICS82: The VISTA–CFHT Stripe 82 Near-infrared Survey

NASA Astrophysics Data System (ADS)

Geach, J. E.; Lin, Y.-T.; Makler, M.; Kneib, J.-P.; Ross, N. P.; Wang, W.-H.; Hsieh, B.-C.; Leauthaud, A.; Bundy, K.; McCracken, H. J.; Comparat, J.; Caminha, G. B.; Hudelot, P.; Lin, L.; Van Waerbeke, L.; Pereira, M. E. S.; Mast, D.

2017-07-01

We present the VISTA–CFHT Stripe 82 (VICS82) survey: a near-infrared (J+Ks) survey covering 150 square degrees of the Sloan Digital Sky Survey (SDSS) equatorial Stripe 82 to an average depth of J = 21.9 AB mag and Ks = 21.4 AB mag (80% completeness limits; 5σ point-source depths are approximately 0.5 mag brighter). VICS82 contributes to the growing legacy of multiwavelength data in the Stripe 82 footprint. The addition of near-infrared photometry to the existing SDSS Stripe 82 coadd ugriz photometry reduces the scatter in stellar mass estimates to δ {log}({M}\\star )≈ 0.3 dex for galaxies with {M}\\star > {10}9 {M}ȯ at z≈ 0.5, and offers improvement compared to optical-only estimates out to z≈ 1, with stellar masses constrained within a factor of approximately 2.5. When combined with other multiwavelength imaging of the Stripe, including moderate-to-deep ultraviolet (GALEX), optical and mid-infrared (Spitzer-IRAC) coverage, as well as tens of thousands of spectroscopic redshifts, VICS82 gives access to approximately 0.5 Gpc3 of comoving volume. Some of the main science drivers of VICS82 include (a) measuring the stellar mass function of {L}\\star galaxies out to z∼ 1; (b) detecting intermediate-redshift quasars at 2≲ z≲ 3.5; (c) measuring the stellar mass function and baryon census of clusters of galaxies, and (d) performing cross-correlation experiments of cosmic microwave background lensing in the optical/near-infrared that link stellar mass to large-scale dark matter structure. Here we define and describe the survey, highlight some early science results, and present the first public data release, which includes an SDSS-matched catalog as well as the calibrated pixel data themselves.

Comparing SMAP to Macro-scale and Hyper-resolution Land Surface Models over Continental U. S.

NASA Astrophysics Data System (ADS)

Pan, Ming; Cai, Xitian; Chaney, Nathaniel; Wood, Eric

2016-04-01

SMAP sensors collect moisture information in top soil at the spatial resolution of ~40 km (radiometer) and ~1 to 3 km (radar, before its failure in July 2015). Such information is extremely valuable for understanding various terrestrial hydrologic processes and their implications on human life. At the same time, soil moisture is a joint consequence of numerous physical processes (precipitation, temperature, radiation, topography, crop/vegetation dynamics, soil properties, etc.) that happen at a wide range of scales from tens of kilometers down to tens of meters. Therefore, a full and thorough analysis/exploration of SMAP data products calls for investigations at multiple spatial scales - from regional, to catchment, and to field scales. Here we first compare the SMAP retrievals to the Variable Infiltration Capacity (VIC) macro-scale land surface model simulations over the continental U. S. region at 3 km resolution. The forcing inputs to the model are merged/downscaled from a suite of best available data products including the NLDAS-2 forcing, Stage IV and Stage II precipitation, GOES Surface and Insolation Products, and fine elevation data. The near real time VIC simulation is intended to provide a source of large scale comparisons at the active sensor resolution. Beyond the VIC model scale, we perform comparisons at 30 m resolution against the recently developed HydroBloks hyper-resolution land surface model over several densely gauged USDA experimental watersheds. Comparisons are also made against in-situ point-scale observations from various SMAP Cal/Val and field campaign sites.

Large-scale runoff generation - parsimonious parameterisation using high-resolution topography

NASA Astrophysics Data System (ADS)

Gong, L.; Halldin, S.; Xu, C.-Y.

2011-08-01

World water resources have primarily been analysed by global-scale hydrological models in the last decades. Runoff generation in many of these models are based on process formulations developed at catchments scales. The division between slow runoff (baseflow) and fast runoff is primarily governed by slope and spatial distribution of effective water storage capacity, both acting at very small scales. Many hydrological models, e.g. VIC, account for the spatial storage variability in terms of statistical distributions; such models are generally proven to perform well. The statistical approaches, however, use the same runoff-generation parameters everywhere in a basin. The TOPMODEL concept, on the other hand, links the effective maximum storage capacity with real-world topography. Recent availability of global high-quality, high-resolution topographic data makes TOPMODEL attractive as a basis for a physically-based runoff-generation algorithm at large scales, even if its assumptions are not valid in flat terrain or for deep groundwater systems. We present a new runoff-generation algorithm for large-scale hydrology based on TOPMODEL concepts intended to overcome these problems. The TRG (topography-derived runoff generation) algorithm relaxes the TOPMODEL equilibrium assumption so baseflow generation is not tied to topography. TRG only uses the topographic index to distribute average storage to each topographic index class. The maximum storage capacity is proportional to the range of topographic index and is scaled by one parameter. The distribution of storage capacity within large-scale grid cells is obtained numerically through topographic analysis. The new topography-derived distribution function is then inserted into a runoff-generation framework similar VIC's. Different basin parts are parameterised by different storage capacities, and different shapes of the storage-distribution curves depend on their topographic characteristics. The TRG algorithm is driven by the HydroSHEDS dataset with a resolution of 3" (around 90 m at the equator). The TRG algorithm was validated against the VIC algorithm in a common model framework in 3 river basins in different climates. The TRG algorithm performed equally well or marginally better than the VIC algorithm with one less parameter to be calibrated. The TRG algorithm also lacked equifinality problems and offered a realistic spatial pattern for runoff generation and evaporation.

Large-scale runoff generation - parsimonious parameterisation using high-resolution topography

NASA Astrophysics Data System (ADS)

Gong, L.; Halldin, S.; Xu, C.-Y.

2010-09-01

World water resources have primarily been analysed by global-scale hydrological models in the last decades. Runoff generation in many of these models are based on process formulations developed at catchments scales. The division between slow runoff (baseflow) and fast runoff is primarily governed by slope and spatial distribution of effective water storage capacity, both acting a very small scales. Many hydrological models, e.g. VIC, account for the spatial storage variability in terms of statistical distributions; such models are generally proven to perform well. The statistical approaches, however, use the same runoff-generation parameters everywhere in a basin. The TOPMODEL concept, on the other hand, links the effective maximum storage capacity with real-world topography. Recent availability of global high-quality, high-resolution topographic data makes TOPMODEL attractive as a basis for a physically-based runoff-generation algorithm at large scales, even if its assumptions are not valid in flat terrain or for deep groundwater systems. We present a new runoff-generation algorithm for large-scale hydrology based on TOPMODEL concepts intended to overcome these problems. The TRG (topography-derived runoff generation) algorithm relaxes the TOPMODEL equilibrium assumption so baseflow generation is not tied to topography. TGR only uses the topographic index to distribute average storage to each topographic index class. The maximum storage capacity is proportional to the range of topographic index and is scaled by one parameter. The distribution of storage capacity within large-scale grid cells is obtained numerically through topographic analysis. The new topography-derived distribution function is then inserted into a runoff-generation framework similar VIC's. Different basin parts are parameterised by different storage capacities, and different shapes of the storage-distribution curves depend on their topographic characteristics. The TRG algorithm is driven by the HydroSHEDS dataset with a resolution of 3'' (around 90 m at the equator). The TRG algorithm was validated against the VIC algorithm in a common model framework in 3 river basins in different climates. The TRG algorithm performed equally well or marginally better than the VIC algorithm with one less parameter to be calibrated. The TRG algorithm also lacked equifinality problems and offered a realistic spatial pattern for runoff generation and evaporation.

Polyborylated reagents for modern organic synthesis

PubMed Central

SHIMIZU, Masaki; HIYAMA, Tamejiro

2008-01-01

Diverse kinds of gem- and vic-diborylated compounds are now readily available thanks to advances in gem-diborylation of lithium carbenoids as well as vic-diborylation of carbon–carbon multiple bonds with diboron compounds. These diborylated reagents lead to invention of polyborylated reagents and many novel and useful synthetic methods for supreme stereocontrol. This review summarizes preparative methods and synthetic reactions of di- and polyborylated reagents with the emphasis on multiple bond formation. PMID:18941288

State and parameter estimation of two land surface models using the ensemble Kalman filter and the particle filter

NASA Astrophysics Data System (ADS)

Zhang, Hongjuan; Hendricks Franssen, Harrie-Jan; Han, Xujun; Vrugt, Jasper A.; Vereecken, Harry

2017-09-01

Land surface models (LSMs) use a large cohort of parameters and state variables to simulate the water and energy balance at the soil-atmosphere interface. Many of these model parameters cannot be measured directly in the field, and require calibration against measured fluxes of carbon dioxide, sensible and/or latent heat, and/or observations of the thermal and/or moisture state of the soil. Here, we evaluate the usefulness and applicability of four different data assimilation methods for joint parameter and state estimation of the Variable Infiltration Capacity Model (VIC-3L) and the Community Land Model (CLM) using a 5-month calibration (assimilation) period (March-July 2012) of areal-averaged SPADE soil moisture measurements at 5, 20, and 50 cm depths in the Rollesbroich experimental test site in the Eifel mountain range in western Germany. We used the EnKF with state augmentation or dual estimation, respectively, and the residual resampling PF with a simple, statistically deficient, or more sophisticated, MCMC-based parameter resampling method. The performance of the calibrated LSM models was investigated using SPADE water content measurements of a 5-month evaluation period (August-December 2012). As expected, all DA methods enhance the ability of the VIC and CLM models to describe spatiotemporal patterns of moisture storage within the vadose zone of the Rollesbroich site, particularly if the maximum baseflow velocity (VIC) or fractions of sand, clay, and organic matter of each layer (CLM) are estimated jointly with the model states of each soil layer. The differences between the soil moisture simulations of VIC-3L and CLM are much larger than the discrepancies among the four data assimilation methods. The EnKF with state augmentation or dual estimation yields the best performance of VIC-3L and CLM during the calibration and evaluation period, yet results are in close agreement with the PF using MCMC resampling. Overall, CLM demonstrated the best performance for the Rollesbroich site. The large systematic underestimation of water storage at 50 cm depth by VIC-3L during the first few months of the evaluation period questions, in part, the validity of its fixed water table depth at the bottom of the modeled soil domain.

An agricultural drought index to incorporate the irrigation process and reservoir operations: A case study in the Tarim River Basin

NASA Astrophysics Data System (ADS)

Li, Zehua; Hao, Zhenchun; Shi, Xiaogang; Déry, Stephen J.; Li, Jieyou; Chen, Sichun; Li, Yongkun

2016-08-01

To help the decision making process and reduce climate change impacts, hydrologically-based drought indices have been used to determine drought severity in the Tarim River Basin (TRB) over the past decades. As the major components of the surface water balance, however, the irrigation process and reservoir operations have not been incorporated into drought indices in previous studies. Therefore, efforts are needed to develop a new agricultural drought index, which is based on the Variable Infiltration Capacity (VIC) model coupled with an irrigation scheme and a reservoir module. The new drought index was derived from the simulated soil moisture data from a retrospective VIC simulation from 1961 to 2007 over the irrigated area in the TRB. The physical processes in the coupled VIC model allow the new agricultural drought index to take into account a wide range of hydrologic processes including the irrigation process and reservoir operations. Notably, the irrigation process was found to dominate the surface water balance and drought evolution in the TRB. Furthermore, the drought conditions identified by the new agricultural drought index presented a good agreement with the historical drought events that occurred in 1993-94, 2004, and 2006-07, respectively. Moreover, the spatial distribution of coupled VIC model outputs using the new drought index provided detailed information about where and to what extent droughts occurred.

Legislation to institutionalize resources for tobacco control: the 1987 Victorian Tobacco Act.

PubMed

Borland, Ron; Winstanley, Margaret; Reading, Dorothy

2009-10-01

  To describe the process surrounding the creation of the first organization in the world to be funded from an earmarked tax on tobacco products, the Victorian Health Promotion Foundation (VicHealth), and to outline briefly its subsequent history. The genesis of VicHealth came from an interest of the Minister for Health in the Victorian State Government to address the tobacco problem, and the strategic capacity of Dr Nigel Gray from the Anti-Cancer Council of Victoria to provide a vehicle and help the government to muster support for its implementation. Success involved working with government to construct a Bill it was happy with and then working with the community to support the implementation and to counter industry attempts to derail it. The successful Bill led to the creation of VicHealth. VicHealth has played a creative and important role in promoting health not only in Victoria (Australia), but has been a stimulus for similar initiatives in other parts of the world. Enacting novel advances in public policy is made easier when there is a creative alliance between advocates outside government working closely with governments to develop a proposal that is politically achievable and then to work together to sell it. Health promotion agencies, once established, can play an important role in advancing issues like tobacco control. © 2009 The Authors. Journal compilation © 2009 Society for the Study of Addiction.

3D Bioprinting of Heterogeneous Aortic Valve Conduits with Alginate/Gelatin Hydrogels

PubMed Central

Duan, Bin; Hockaday, Laura A.; Kang, Kevin H.; Butcher, Jonathan T.

2013-01-01

Heart valve disease is a serious and growing public health problem for which prosthetic replacement is most commonly indicated. Current prosthetic devices are inadequate for younger adults and growing children. Tissue engineered living aortic valve conduits have potential for remodeling, regeneration, and growth, but fabricating natural anatomical complexity with cellular heterogeneity remain challenging. In the current study, we implement 3D bioprinting to fabricate living alginate/gelatin hydrogel valve conduits with anatomical architecture and direct incorporation of dual cell types in a regionally constrained manner. Encapsulated aortic root sinus smooth muscle cells (SMC) and aortic valve leaflet interstitial cells (VIC) were viable within alginate/gelatin hydrogel discs over 7 days in culture. Acellular 3D printed hydrogels exhibited reduced modulus, ultimate strength, and peak strain reducing slightly over 7-day culture, while the tensile biomechanics of cell-laden hydrogels were maintained. Aortic valve conduits were successfully bioprinted with direct encapsulation of SMC in the valve root and VIC in the leaflets. Both cell types were viable (81.4±3.4% for SMC and 83.2±4.0% for VIC) within 3D printed tissues. Encapsulated SMC expressed elevated alpha-smooth muscle actin when printed in stiff matrix, while VIC expressed elevated vimentin in soft matrix. These results demonstrate that anatomically complex, heterogeneously encapsulated aortic valve hydrogel conduits can be fabricated with 3D bioprinting. PMID:23015540

Phylogenetic and pathogenic characterization of a pigeon paramyxovirus type 1 isolate reveals cross-species transmission and potential outbreak risks in the northwest region of China.

PubMed

Ren, Shanhui; Wang, Chongyang; Zhang, Xue; Zhao, Lei; Wang, Xiangwei; Yao, Wei; Han, Qingsong; Wang, Yanhong; Fan, Mengfei; Gao, Xiaolong; Xiao, Sa; Wang, Xinglong; Yang, Zengqi

2017-09-01

Pigeon paramyxovirus type-1 (PPMV-1) is enzootic in pigeons, causing severe economic loss in the poultry industry in many countries. However, the exact epidemic process of PPMV-1 transmission is still unclear. In this study, we analyzed the complete genome of the PPMV-1/SX-01/15 isolate. Sequence results show that the virus genome contains 15,192 nucleotides, with the gene order 3'-NP-P-M-F-HN-L-5'. Phylogenetic analysis revealed that this genome belongs to subgenotype VIc in class II. The mean death time (MDT) and intracerebral pathogenicity index (ICPI) were 62.4 h and 1.13, respectively, indicating that this isolate is a mesogenic PPMV-1 strain. To our knowledge, this is the first report of a subgenotype VIc mesogenic PPMV-1 strain circulating in commercial pigeon flocks in the northwest region of China. In a comparative infection experiment, the morbidity and mortality rates were 100% and 80%, respectively, in 4-week-old pigeons, whereas they were 50% and 30%, respectively, in 5-week-old chickens. Furthermore, this virus caused severe neurological symptoms in a 4-week-old pigeon and mild neurological symptoms in a 5-week-old chicken. A histopathological examination of the brain showed a classical nonsuppurative encephalitis lesion. The pattern of viral shedding, and viral load, and virus distribution differed between infected chickens and pigeons. Genomic characteristics suggest that there was cross-species transmission of PPMV-1 subgenotype VIc in this region at least from the years 2006 to 2015.

A hydrological emulator for global applications - HE v1.0.0

NASA Astrophysics Data System (ADS)

Liu, Yaling; Hejazi, Mohamad; Li, Hongyi; Zhang, Xuesong; Leng, Guoyong

2018-03-01

While global hydrological models (GHMs) are very useful in exploring water resources and interactions between the Earth and human systems, their use often requires numerous model inputs, complex model calibration, and high computation costs. To overcome these challenges, we construct an efficient open-source and ready-to-use hydrological emulator (HE) that can mimic complex GHMs at a range of spatial scales (e.g., basin, region, globe). More specifically, we construct both a lumped and a distributed scheme of the HE based on the monthly abcd model to explore the tradeoff between computational cost and model fidelity. Model predictability and computational efficiency are evaluated in simulating global runoff from 1971 to 2010 with both the lumped and distributed schemes. The results are compared against the runoff product from the widely used Variable Infiltration Capacity (VIC) model. Our evaluation indicates that the lumped and distributed schemes present comparable results regarding annual total quantity, spatial pattern, and temporal variation of the major water fluxes (e.g., total runoff, evapotranspiration) across the global 235 basins (e.g., correlation coefficient r between the annual total runoff from either of these two schemes and the VIC is > 0.96), except for several cold (e.g., Arctic, interior Tibet), dry (e.g., North Africa) and mountainous (e.g., Argentina) regions. Compared against the monthly total runoff product from the VIC (aggregated from daily runoff), the global mean Kling-Gupta efficiencies are 0.75 and 0.79 for the lumped and distributed schemes, respectively, with the distributed scheme better capturing spatial heterogeneity. Notably, the computation efficiency of the lumped scheme is 2 orders of magnitude higher than the distributed one and 7 orders more efficient than the VIC model. A case study of uncertainty analysis for the world's 16 basins with top annual streamflow is conducted using 100 000 model simulations, and it demonstrates the lumped scheme's extraordinary advantage in computational efficiency. Our results suggest that the revised lumped abcd model can serve as an efficient and reasonable HE for complex GHMs and is suitable for broad practical use, and the distributed scheme is also an efficient alternative if spatial heterogeneity is of more interest.

Aortic calcified particles modulate valvular endothelial and interstitial cells.

PubMed

van Engeland, Nicole C A; Bertazzo, Sergio; Sarathchandra, Padmini; McCormack, Ann; Bouten, Carlijn V C; Yacoub, Magdi H; Chester, Adrian H; Latif, Najma

Normal and calcified human valve cusps, coronary arteries, and aortae harbor spherical calcium phosphate microparticles of identical composition and crystallinity, and their role remains unknown. The objective was to examine the direct effects of isolated calcified particles on human valvular cells. Calcified particles were isolated from healthy and diseased aortae, characterized, quantitated, and applied to valvular endothelial cells (VECs) and interstitial cells (VICs). Cell differentiation, viability, and proliferation were analyzed. Particles were heterogeneous, differing in size and shape, and were crystallized as calcium phosphate. Diseased donors had significantly more calcified particles compared to healthy donors (P<.05), but there were no differences between the composition of the particles from healthy and diseased donors. VECs treated with calcified particles showed a significant decrease in CD31 and VE-cadherin and an increase in von Willebrand factor expression, P<.05. There were significantly increased α-SMA and osteopontin in treated VICs (P<.05), significantly decreased VEC and VIC viability (P<.05), and significantly increased number of terminal deoxynucleotidyl transferase dUTP nick end labeling-positive VECs (P<.05) indicating apoptosis when treated with the calcified particles. Isolated calcified particles from human aortae are not innocent bystanders but induce a phenotypical and pathological change of VECs and VICs characteristic of activated and pathological cells. Therapy tailored to reduce these calcified particles should be investigated. Copyright © 2017 Elsevier Inc. All rights reserved.

Passing in Command Line Arguments and Parallel Cluster/Multicore Batching in R with batch.

PubMed

Hoffmann, Thomas J

2011-03-01

It is often useful to rerun a command line R script with some slight change in the parameters used to run it - a new set of parameters for a simulation, a different dataset to process, etc. The R package batch provides a means to pass in multiple command line options, including vectors of values in the usual R format, easily into R. The same script can be setup to run things in parallel via different command line arguments. The R package batch also provides a means to simplify this parallel batching by allowing one to use R and an R-like syntax for arguments to spread a script across a cluster or local multicore/multiprocessor computer, with automated syntax for several popular cluster types. Finally it provides a means to aggregate the results together of multiple processes run on a cluster.

Hydrological variability in the Fraser River Basin during the 20th century: A sensitivity study with the VIC model

NASA Astrophysics Data System (ADS)

Kang, D.; Gao, H.; Dery, S. J.

2012-12-01

The Variable Infiltration Capacity (VIC) model, a macroscale surface hydrology model, was applied to the Fraser River Basin (FRB) of British Columbia, Canada. Previous modeling studies have demonstrated that the FRB is a snow-dominated system but with climate change may evolve to a pluvial regime. The ultimate goal of this model application is to evaluate the changing contribution of snowmelt to streamflow in the FRB both spatially and temporally. To this end, the National Centers for Environmental Prediction (NCEP) reanalysis data combined with meteorological observations over 1953 to 2006 are used to drive the model at a resolution of 0.25°. Model simulations are first validated with daily discharge observations from the Water Survey of Canada (WSC). In addition, the snow water equivalent (SWE) results from VIC are compared with snow pillow observations from the B.C. Ministry of Environment. Then peak SWE values simulated each winter are compared with the annual runoff data to quantify the changing contribution of snowmelt to the hydrology of the FRB. With perturbed model forcings such as precipitation and air temperature, how streamflow and surface energy-mass balance are changed is evaluated. Finally, interactions between the land surface and ambient atmosphere are evaluated by analyzing VIC results such as evaporation, soil moisture, snowmelt and sensible-latent heat flux with corresponding meteorological forcings, i.e. precipitation and air temperature.

Secure Recognition of Voice-Less Commands Using Videos

NASA Astrophysics Data System (ADS)

Yau, Wai Chee; Kumar, Dinesh Kant; Weghorn, Hans

Interest in voice recognition technologies for internet applications is growing due to the flexibility of speech-based communication. The major drawback with the use of sound for internet access with computers is that the commands will be audible to other people in the vicinity. This paper examines a secure and voice-less method for recognition of speech-based commands using video without evaluating sound signals. The proposed approach represents mouth movements in the video data using 2D spatio-temporal templates (STT). Zernike moments (ZM) are computed from STT and fed into support vector machines (SVM) to be classified into one of the utterances. The experimental results demonstrate that the proposed technique produces a high accuracy of 98% in a phoneme classification task. The proposed technique is demonstrated to be invariant to global variations of illumination level. Such a system is useful for securely interpreting user commands for internet applications on mobile devices.

Mechanism of groundwater arsenic removal by goethite-coated mineral sand

NASA Astrophysics Data System (ADS)

Cashion, J. D.; Khan, S. A.; Patti, A. F.; Adeloju, S.; Gates, W. P.

2017-11-01

Skye sand (Vic, Australia) has been considered for arsenic removal from groundwater. Analysis showed that the silica sand is coated with poorly crystalline goethite, hematite and clay minerals. Mössbauer spectra taken following arsenic adsorption revealed changes in the recoilless fraction and relaxation behaviour of the goethite compared to the original state, showing that the goethite is the main active species.

Did Climate Change Cause the 2012-2014 California Drought?

NASA Astrophysics Data System (ADS)

Mao, Y.; Clark, E.; Xiao, M.; Nijssen, B.; Lettenmaier, D. P.

2014-12-01

California has experienced severe drought over the last three years, with especially deficient winter precipitation and mountain snowpack in 2013-2014. While the severity of California's water crisis this year is not in question, the causes of the drought are less clear, and there has been debate as to whether human-induced climate change is at least in part a cause of anomalously low winter precipitation (P) and snow water equivalent (SWE) this year, or whether the conditions are simply the result of natural variability that has been manifested in previous severe droughts in California. To provide more scientific insight to this question, we reconstructed, using the Variable Infiltration Capacity (VIC) hydrologic model, SWE and runoff from 1920 to 2014 at a spatial resolution of 1/16 degree over the Sierra Nevada range of California. We forced the VIC model with a temporally consistent set of index precipitation and temperature stations that are also used in the University of Washington's Drought Monitoring System for the West Coast Region (http://www.hydro.washington.edu/forecast/monitor_cali/index.shtml). We carried out trend analysis and examined cumulative probability for accumulated winter precipitation, SWE on Apr 1, annual, spring and winter runoff, average winter temperature (T) and SWE/P fraction. We also did correlation analysis between SWE and P as well as SWE and T. In addition, we used detrended temperature data to force the VIC model in order to analyze the role of climate change in SWE and runoff. Our results show that while the decreasing trend in SWE and earlier runoff peak in the year are related to long-term warming climate, there is no significant trend in winter P and there are lots of variability in the record of all variables. While this year's anomalously warm weather might have exacerbated the ongoing 3-year drought (and winter 2013-14 in particular), we conclude that natural variability is the main cause.

Synthesis, analgesic, anti-inflammatory and anti-ulcerogenic activities of certain novel Schiff's bases as fenamate isosteres.

PubMed

Alafeefy, Ahmed M; Bakht, Mohammed A; Ganaie, Majid A; Ansarie, Mohd N; El-Sayed, Nahed N; Awaad, Amani S

2015-01-15

A series of certain novel Schiff bases as fenamate isosteres (VI:a-k) were synthesized to locate analgesic, anti-inflammatory agent with minimal ulcerogenic potential. The structures of the newly synthesized compounds were elucidated on the basis of their elemental analysis as well as IR, and NMR and mass spectroscopic data. All the compounds were evaluated for their anti-inflammatory activity by carrageenan induced paw oedema method. The compounds possessing good anti-inflammatory activity were further tested for analgesic, ulcerogenic, lipid peroxidation potentials and liver toxicity. Compounds (VI-c), (VI-f), (VI-h) and (VI-i) showed the best anti-inflammatory and significant analgesic activities at doses comparable to that of the standard drug Indomethacin. However, compounds (VI-c) and (VI-f) could be considered the most potent anti-inflammatory and analgesic molecules with maximum reduction in gastro-intestinal ulceration with no hepatocyte necrosis or liver degeneration. Copyright © 2014 Elsevier Ltd. All rights reserved.

Dismounted Warrior Network Experiments

DTIC Science & Technology

2000-11-01

Foxtrot Locomotion Human Joystick ODT Joystick Foot Pedal + Head Orientation Visual Display Wireless HMD 4 Projection Desktop Single Screens (WISE... Biomechanics DI-Guy JackML DI-Guy Table 1. VICs Comparison Matrix VIC Alpha is the Dismounted Soldier Simulation (DSS) system developed by Veda, Inc. under a...using a pressure sensitive foot pedal . The user’s head is tracked with a magnetic sensor and is used to control steering through the environment. A

Special-Purpose High-Torque Permanent-Magnet Motors

NASA Technical Reports Server (NTRS)

Doane, George B., III

1995-01-01

Permanent-magnet brushless motors that must provide high commanded torques and satisfy unusual heat-removal requirement are developed. Intended for use as thrust-vector-control actuators in large rocket engines. Techniques and concepts used to design improved motors for special terrestrial applications. Conceptual motor design calls for use of rotor containing latest high-energy-product rare-earth permanent magnets so that motor produces required torque while drawing smallest possible currents from power supply. Torque generated by electromagnetic interaction between stator and permanent magnets in rotor when associated electronic circuits applied appropriately temporally and spatially phased currents to stator windings. Phase relationships needed to produce commanded torque computed in response to torque command and to electronically sensed angular position of rotor relative to stator.

Fast food purchasing and access to fast food restaurants: a multilevel analysis of VicLANES.

PubMed

Thornton, Lukar E; Bentley, Rebecca J; Kavanagh, Anne M

2009-05-27

While previous research on fast food access and purchasing has not found evidence of an association, these studies have had methodological problems including aggregation error, lack of specificity between the exposures and outcomes, and lack of adjustment for potential confounding. In this paper we attempt to address these methodological problems using data from the Victorian Lifestyle and Neighbourhood Environments Study (VicLANES) - a cross-sectional multilevel study conducted within metropolitan Melbourne, Australia in 2003. The VicLANES data used in this analysis included 2547 participants from 49 census collector districts in metropolitan Melbourne, Australia. The outcome of interest was the total frequency of fast food purchased for consumption at home within the previous month (never, monthly and weekly) from five major fast food chains (Red Rooster, McDonalds, Kentucky Fried Chicken, Hungry Jacks and Pizza Hut). Three measures of fast food access were created: density and variety, defined as the number of fast food restaurants and the number of different fast food chains within 3 kilometres of road network distance respectively, and proximity defined as the road network distance to the closest fast food restaurant.Multilevel multinomial models were used to estimate the associations between fast food restaurant access and purchasing with never purchased as the reference category. Models were adjusted for confounders including determinants of demand (attitudes and tastes that influence food purchasing decisions) as well as individual and area socio-economic characteristics. Purchasing fast food on a monthly basis was related to the variety of fast food restaurants (odds ratio 1.13; 95% confidence interval 1.02 - 1.25) after adjusting for individual and area characteristics. Density and proximity were not found to be significant predictors of fast food purchasing after adjustment for individual socio-economic predictors. Although we found an independent association between fast food purchasing and access to a wider variety of fast food restaurant, density and proximity were not significant predictors. The methods used in our study are an advance on previous analyses.

Methods, systems and apparatus for controlling third harmonic voltage when operating a multi-space machine in an overmodulation region

DOEpatents

Perisic, Milun; Kinoshita, Michael H; Ranson, Ray M; Gallegos-Lopez, Gabriel

2014-06-03

Methods, system and apparatus are provided for controlling third harmonic voltages when operating a multi-phase machine in an overmodulation region. The multi-phase machine can be, for example, a five-phase machine in a vector controlled motor drive system that includes a five-phase PWM controlled inverter module that drives the five-phase machine. Techniques for overmodulating a reference voltage vector are provided. For example, when the reference voltage vector is determined to be within the overmodulation region, an angle of the reference voltage vector can be modified to generate a reference voltage overmodulation control angle, and a magnitude of the reference voltage vector can be modified, based on the reference voltage overmodulation control angle, to generate a modified magnitude of the reference voltage vector. By modifying the reference voltage vector, voltage command signals that control a five-phase inverter module can be optimized to increase output voltages generated by the five-phase inverter module.

Regulation of a Viral Proteinase by a Peptide and DNA in One-dimensional Space

PubMed Central

Graziano, Vito; Luo, Guobin; Blainey, Paul C.; Pérez-Berná, Ana J.; McGrath, William J.; Flint, S. Jane; San Martín, Carmen; Xie, X. Sunney; Mangel, Walter F.

2013-01-01

Late in an adenovirus infection, the viral proteinase (AVP) becomes activated to process virion precursor proteins used in virus assembly. AVP is activated by two cofactors, the viral DNA and pVIc, an 11-amino acid peptide originating from the C terminus of the precursor protein pVI. There is a conundrum in the activation of AVP in that AVP and pVI are sequence-independent DNA-binding proteins with nm equilibrium dissociation constants such that in the virus particle, they are predicted to be essentially irreversibly bound to the viral DNA. Here, we resolve that conundrum by showing that activation of AVP takes place on the one-dimensional contour of DNA. In vitro, pVI, a substrate, slides on DNA via one-dimensional diffusion, D1 = 1.45 × 106 bp2/s, until it binds to AVP also on the same DNA molecule. AVP, partially activated by being bound to DNA, excises pVIc, which binds to the AVP molecule that cut it out. pVIc then forms a disulfide bond with AVP forming the fully active AVP-pVIc complex bound to DNA. In vivo, in heat-disrupted immature virus, AVP was also activated by pVI in DNA-dependent reactions. This activation mechanism illustrates a new paradigm for virion maturation and a new way, by sliding on DNA, for bimolecular complexes to form among proteins not involved in DNA metabolism. PMID:23043137

Model based Inverse Methods for Sizing Cracks of Varying Shape and Location in Bolt hole Eddy Current (BHEC) Inspections (Postprint)

DTIC Science & Technology

2016-02-10

using bolt hole eddy current (BHEC) techniques. Data was acquired for a wide range of crack sizes and shapes, including mid- bore , corner and through...to select the most appropriate VIC-3D surrogate model for subsequent crack sizing inversion step. Inversion results for select mid- bore , through and...the flaw. 15. SUBJECT TERMS Bolt hole eddy current (BHEC); mid- bore , corner and through-thickness crack types; VIC-3D generated surrogate models

Multiple two-component systems modulate alkali generation in Streptococcus gordonii in response to environmental stresses.

PubMed

Liu, Yaling; Burne, Robert A

2009-12-01

The oral commensal Streptococcus gordonii must adapt to constantly fluctuating and often hostile environmental conditions to persist in the oral cavity. The arginine deiminase system (ADS) of S. gordonii enables cells to produce, ornithine, ammonia, CO(2), and ATP from arginine hydrolysis, augmenting the acid tolerance of the organism. The ADS genes are substrate inducible and sensitive to catabolite repression, mediated through ArcR and CcpA, respectively, but the system also requires low pH and anaerobic conditions for optimal activation. Here, we demonstrate that the CiaRH and ComDE two-component systems (TCS) are required for low-pH-dependent expression of ADS genes in S. gordonii. Further, the VicRK TCS is required for optimal ADS gene expression under anaerobic conditions and enhances the sensitivity of the operon to repression by oxygen. The known anaerobic activator of the ADS, Fnr-like protein (Flp), appeared to act independently of the Vic TCS. Mutants of S. gordonii lacking components of the CiaRH, ComDE, or VicRK grew more slowly in acidified media and were more sensitive to killing at lethal pH values and to agents that induce oxidative stress. This study provides the first evidence that TCS can regulate the ADS of bacteria in response to specific environmental signals and reveals some notable differences in the contribution of CiaRH, ComDE, and VicRK to viability and stress tolerance between the oral commensal S. gordonii and the oral pathogen Streptococcus mutans.

Macroscale hydrologic modeling of ecologically relevant flow metrics

NASA Astrophysics Data System (ADS)

Wenger, Seth J.; Luce, Charles H.; Hamlet, Alan F.; Isaak, Daniel J.; Neville, Helen M.

2010-09-01

Stream hydrology strongly affects the structure of aquatic communities. Changes to air temperature and precipitation driven by increased greenhouse gas concentrations are shifting timing and volume of streamflows potentially affecting these communities. The variable infiltration capacity (VIC) macroscale hydrologic model has been employed at regional scales to describe and forecast hydrologic changes but has been calibrated and applied mainly to large rivers. An important question is how well VIC runoff simulations serve to answer questions about hydrologic changes in smaller streams, which are important habitat for many fish species. To answer this question, we aggregated gridded VIC outputs within the drainage basins of 55 streamflow gages in the Pacific Northwest United States and compared modeled hydrographs and summary metrics to observations. For most streams, several ecologically relevant aspects of the hydrologic regime were accurately modeled, including center of flow timing, mean annual and summer flows and frequency of winter floods. Frequencies of high and low flows in the summer were not well predicted, however. Predictions were worse for sites with strong groundwater influence, and some sites showed errors that may result from limitations in the forcing climate data. Higher resolution (1/16th degree) modeling provided small improvements over lower resolution (1/8th degree). Despite some limitations, the VIC model appears capable of representing several ecologically relevant hydrologic characteristics in streams, making it a useful tool for understanding the effects of hydrology in delimiting species distributions and predicting the potential effects of climate shifts on aquatic organisms.

Replication of Beta- and Gammaretroviruses Is Restricted in I/LnJ Mice via the Same Genetic Mechanism▿

PubMed Central

Case, Laure K.; Petell, Lydia; Yurkovetskiy, Leonid; Purdy, Alexandra; Savage, Katherine J.; Golovkina, Tatyana V.

2008-01-01

Mice of the I/LnJ inbred strain are unique in their ability to mount a robust and sustained humoral immune response capable of neutralizing infection with a betaretrovirus, mouse mammary tumor virus (MMTV). Virus-neutralizing antibodies (Abs) coat MMTV virions secreted by infected cells, preventing virus spread and hence the formation of mammary tumors. To investigate whether I/LnJ mice resist infection with other retroviruses besides MMTV, the animals were infected with murine leukemia virus (MuLV), a gammaretrovirus. MuLV-infected I/LnJ mice produced virus-neutralizing Abs that block virus transmission and virally induced disease. Generation of virus-neutralizing Abs required gamma interferon but was independent of interleukin-12. This unique mechanism of retrovirus resistance is governed by a single recessive gene, virus infectivity controller 1 (vic1), mapped to chromosome 17. In addition to controlling the antivirus humoral immune response, vic1 is also required for an antiviral cytotoxic response. Both types of responses were maintained in mice of the susceptible genetic background but congenic for the I/LnJ vic1 locus. Although the vic1-mediated resistance to MuLV resembles the mechanism of retroviral recovery controlled by the resistance to Friend virus 3 (rfv3) gene, the rfv3 gene has been mapped to chromosome 15 and confers resistance to MuLV but not to MMTV. Thus, we have identified a unique virus resistance mechanism that controls immunity against two distinct retroviruses. PMID:18057254

A Comparison of Nonlinear Filters for Orbit Determination and Estimation

DTIC Science & Technology

1986-06-01

Com- mand uses a nonlinear least squares filter for element set maintenance for all objects orbiting the Earth (3). These objects, including active...initial state vector is the singularly averaged classical orbital element set provided by SPACECOM/DOA. The state vector in this research consists of...GSF (G) - - 26.0 36.7 GSF(A) 32.1 77.4 38.8 59.6 The Air Force Space Command is responsible for main- taining current orbital element sets for about

Early disease progression in patients with localized natural killer/T-cell lymphoma treated with concurrent chemoradiotherapy.

PubMed

Yamaguchi, Motoko; Suzuki, Ritsuro; Kim, Seok Jin; Ko, Young Hyeh; Oguchi, Masahiko; Asano, Naoko; Miyazaki, Kana; Terui, Yasuhiko; Kubota, Nobuko; Maeda, Takeshi; Kobayashi, Yukio; Amaki, Jun; Soejima, Toshinori; Saito, Bungo; Shimoda, Emiko; Fukuhara, Noriko; Tsukamoto, Norifumi; Shimada, Kazuyuki; Choi, Ilseung; Utsumi, Takahiko; Ejima, Yasuo; Kim, Won Seog; Katayama, Naoyuki

2018-03-30

Prognosis of patients with localized nasal extranodal natural killer/T-cell lymphoma, nasal type (ENKL) has been improved by non-anthracycline-containing treatments such as concurrent chemoradiotherapy (CCRT). However, some patients experience early disease progression. To clarify the clinical features and outcomes of these patients, data from 165 patients with localized nasal ENKL who were diagnosed between 2000 and 2013 at 31 institutes in Japan and who received radiotherapy with dexamethasone, etoposide, ifosfamide, and carboplatin (RT-DeVIC) were retrospectively analyzed. Progression of disease within 2 years after diagnosis (POD24) was used as the definition of early progression. An independent dataset of 60 patients with localized nasal ENKL who received CCRT at Samsung Medical Center was used in the validation analysis. POD24 was documented in 23% of patients who received RT-DeVIC and in 25% of patients in the validation cohort. Overall survival (OS) from risk-defining events of the POD24 group was inferior to that of the reference group in both cohorts (P < .00001). In the RT-DeVIC cohort, pretreatment elevated levels of serum soluble interleukin-2 receptor (sIL-2R), lactate dehydrogenase, C-reactive protein, and detectable Epstein-Barr virus DNA in peripheral blood were associated with POD24. In the validation cohort, no pretreatment clinical factor associated with POD24 was identified. Our study indicates that POD24 is a strong indicator of survival in localized ENKL, despite the different CCRT regimens adopted. In the treatment of localized nasal ENKL, POD24 is useful for identifying patients who have unmet medical needs. © 2018 The Authors. Cancer Science published by John Wiley & Sons Australia, Ltd on behalf of Japanese Cancer Association.

Protective role of Smad6 in inflammation-induced valvular cell calcification

PubMed Central

Li, Xin; Lim, Jina J.; Lu, Jinxiu; Pedego, Taylor M.; Demer, Linda; Tintut, Yin

2016-01-01

Calcific aortic vascular and valvular disease (CAVD) is associated with hyperlipidemia, the effects of which occur through chronic inflammation. Evidence suggests that inhibitory small mothers against decapentaplegic (I-Smads; Smad6 and 7) regulate valve embryogenesis and may serve as a mitigating factor in CAVD. However, whether I-Smads regulate inflammation-induced calcific vasculopathy is not clear. Therefore, we investigated the role of I-Smads in atherosclerotic calcification. Results showed that expression of Smad6, but not Smad7, was reduced in aortic and valve tissues of hyperlipidemic compared with normolipemic mice, while expression of tumor necrosis factor alpha (TNF-a) was upregulated. To test whether the effects are in response to inflammatory cytokines, we isolated murine aortic valve leaflets and cultured valvular interstitial cells (mVIC) from the normolipemic mice. By immunochemistry, mVICs were strongly positive for vimentin, weakly positive for smooth muscle alpha actin, and negative for an endothelial cell marker. TNF-a upregulated alkaline phosphatase (ALP) activity and matrix mineralization in mVICs. By gene expression analysis, TNF-a significantly upregulated bone morphogenetic protein 2 (BMP-2) expression while downregulating Smad6 expression. Smad7 expression was not significantly affected. To further test the role of Smad6 on TNF-a-induced valvular cell calcification, we knocked down Smad6 expression using lentiviral transfection. In cells transfected with Smad6 shRNA, TNF-a further augmented ALP activity, expression of BMP-2, Wnt- and redox-regulated genes, and matrix mineralization compared with the control cells. These findings suggest that TNF-a induces valvular and vascular cell calcification, in part, by specifically reducing the expression of a BMP-2 signaling inhibitor, Smad6. PMID:25864564

Protective Role of Smad6 in Inflammation-Induced Valvular Cell Calcification.

PubMed

Li, Xin; Lim, Jina; Lu, Jinxiu; Pedego, Taylor M; Demer, Linda; Tintut, Yin

2015-10-01

Calcific aortic vascular and valvular disease (CAVD) is associated with hyperlipidemia, the effects of which occur through chronic inflammation. Evidence suggests that inhibitory small mothers against decapentaplegic (I-Smads; Smad6 and 7) regulate valve embryogenesis and may serve as a mitigating factor in CAVD. However, whether I-Smads regulate inflammation-induced calcific vasculopathy is not clear. Therefore, we investigated the role of I-Smads in atherosclerotic calcification. Results showed that expression of Smad6, but not Smad7, was reduced in aortic and valve tissues of hyperlipidemic compared with normolipemic mice, while expression of tumor necrosis factor alpha (TNF-α) was upregulated. To test whether the effects are in response to inflammatory cytokines, we isolated murine aortic valve leaflets and cultured valvular interstitial cells (mVIC) from the normolipemic mice. By immunochemistry, mVICs were strongly positive for vimentin, weakly positive for smooth muscle α actin, and negative for an endothelial cell marker. TNF-α upregulated alkaline phosphatase (ALP) activity and matrix mineralization in mVICs. By gene expression analysis, TNF-α significantly upregulated bone morphogenetic protein 2 (BMP-2) expression while downregulating Smad6 expression. Smad7 expression was not significantly affected. To further test the role of Smad6 on TNF-α-induced valvular cell calcification, we knocked down Smad6 expression using lentiviral transfection. In cells transfected with Smad6 shRNA, TNF-α further augmented ALP activity, expression of BMP-2, Wnt- and redox-regulated genes, and matrix mineralization compared with the control cells. These findings suggest that TNF-α induces valvular and vascular cell calcification, in part, by specifically reducing the expression of a BMP-2 signaling inhibitor, Smad6. © 2015 Wiley Periodicals, Inc.

Trends in soil moisture and real evapotranspiration in Douro River for the period 1980-2010

NASA Astrophysics Data System (ADS)

García-Valdecasas-Ojeda, Matilde; de Franciscis, Sebastiano; Raquel Gámiz-Fortis, Sonia; Castro-Díez, Yolanda; Jesús Esteban-Parra, María

2017-04-01

This study analyzes the evolution of different hydrological variables, such as soil moisture and real evapotranspiration, for the last 30 years, in the Douro Basin, the most extensive basin in the Iberian Peninsula. The different components of the real evaporation, connected to the soil moisture content, can be important when analyzing the intensity of droughts and heat waves, and particularly relevant for the study of the climate change impacts. The real evapotranspiration and soil moisture data are provided by simulations obtained using the Variable Infiltration Capacity (VIC) hydrological model. This model is a large-scale hydrologic model and allows estimates of different variables in the hydrological system of a basin. Land surface is modeled as a grid of large and uniform cells with sub-grid heterogeneity (e.g. land cover), while water influx is local, only depending from the interaction between grid cells and local atmosphere environment. Observational data of temperature and precipitation from Spain02 dataset are used as input variables for VIC model. The simulations have a spatial resolution of about 9 km, and the analysis is carried out on a seasonal time-scale. Additionally, we compare these results with those obtained from a dynamical downscaling driven by ERA-Interim data using the Weather Research and Forecasting (WRF) model, with the same spatial resolution. The results obtained from Spain02 data show a decrease in soil moisture at different parts of the basin during spring and summer, meanwhile soil moisture seems to be increased for autumn. No significant changes are found for real evapotranspiration. Keywords: real evapotranspiration, soil moisture, Douro Basin, trends, VIC, WRF. Acknowledgements: This work has been financed by the projects P11-RNM-7941 (Junta de Andalucía-Spain) and CGL2013-48539-R (MINECO-Spain, FEDER).

Photocrosslinking of gelatin macromers to synthesize porous hydrogels that promote valvular interstitial cell function.

PubMed

Benton, Julie A; DeForest, Cole A; Vivekanandan, Vani; Anseth, Kristi S

2009-11-01

The development of novel three-dimensional cell culture platforms for the culture of aortic valvular interstitial cells (VICs) has been fraught with many challenges. Although the most tunable, purely synthetic systems have not been successful at promoting cell survivability or function. On the other hand, entirely natural materials lack mechanical integrity. Here we explore a novel hybrid system consisting of gelatin macromers synthetically modified with methacrylate functionalities allowing for photoencapsulation of cells. Scanning electron microscopy observations show a microporous structure induced during polymerization within the hydrogel. This porous structure was tunable with polymerization rate and did not appear to have interconnected pores. Treatment with collagenase caused bulk erosion indicating enzymatic degradation controls the matrix remodeling. VICs, an important cell line for heart valve tissue engineering, were photoencapsulated and examined for cell-directed migration and differentiation. VICs were able to achieve their native morphology within 2 weeks of culture. The addition of the pro-fibrotic growth factor, transforming growth factor-beta1, accelerated this process and also was capable of inducing enhanced alpha-smooth muscle actin and collagen-1 expression, indicating a differentiation from quiescent fibroblasts to active myofibroblasts as demonstrated by quantitative real-time polymerase chain reaction and immunohistochemistry. Although these studies were limited to VICs, this novel hydrogel system may also be useful for studying other fibroblastic cell types.

Betulin inhibits cariogenic properties of Streptococcus mutans by targeting vicRK and gtf genes.

PubMed

Viszwapriya, Dharmaprakash; Subramenium, Ganapathy Ashwinkumar; Radhika, Solai; Pandian, Shunmugiah Karutha

2017-01-01

Streptococcus mutans, a multivirulent pathogen is considered the primary etiological agent in dental caries. Development of antibiotic resistance in the pathogen has created a need for novel antagonistic agents which can control the virulence of the organism and reduce resistance development. The present study demonstrates the in vitro anti-virulence potential of betulin (lup-20(29)-ene-3β,28-diol), an abundantly available plant triterpenoid against S. mutans UA159. Betulin exhibited significant dose dependent antibiofilm activity without affecting bacterial viability. At 240 µg/ml (biofilm inhibitory concentration), betulin inhibited biofilm formation and adherence to smooth glass surfaces by 93 and 71 % respectively. It reduced water insoluble glucan synthesis by 89 %, in conjunction with down regulation of gtfBC genes. Microscopic analysis confirmed the disruption in biofilm architecture and decreased exopolysaccharide production. Acidogenicity and aciduricity, key virulence factors responsible for carious lesions, were also notably affected. The induced auto-aggregation of cells upon treatment could be due to the down regulation of vicK. Results of gene expression analysis demonstrated significant down-regulation of virulence genes upon betulin treatment. Furthermore, the nontoxic effect of betulin on peripheral blood mononuclear cells even after 72 h treatment makes it a strong candidate for assessing its suitability to be used as a therapeutic agent.

Support for breaking the nexus between alcohol and community sports settings: findings from the VicHealth Community Attitudes Survey in Australia.

PubMed

Tobin, Claire L; Fitzgerald, John L; Livingstone, Charles; Thomson, Lisa; Harper, Todd A

2012-06-01

This study describes levels and predictors of community attitudes towards alcohol, support for structural alterations to the drinking context, and intention to increase participation in community sports clubs. Cross-sectional data were obtained from the VicHealth Community Attitudes Survey on Healthy Sporting Environments, administered to a random sample of Victorian adults. Descriptive and multivariate logistic regression analysis was undertaken. Very high support for removing alcohol sponsorship of community sport and for a levy on alcohol advertising was found. The groups most supportive of breaking the nexus between alcohol and community sport were female, older-aged and non-English-speaking citizens and those not involved in sport clubs. If alcohol sales at community sports clubs were reduced, participation may increase among population groups currently identified as least engaged with community sport. An optimal climate exists for policy reforms to make community sporting environments healthier by reducing the ties with alcohol. If implemented, these reforms may lead to an increase and diversification of participants in community sport. © 2011 Australasian Professional Society on Alcohol and other Drugs.

Development of a SMAP-Based Drought Monitoring Product

NASA Astrophysics Data System (ADS)

Sadri, S.; Wood, E. F.; Pan, M.; Lettenmaier, D. P.

2016-12-01

Agricultural drought is defined as a deficit in the amount of soil moisture over a prolonged period of time. Soil moisture information over time and space provides critical insight for agricultural management, including both water availability for crops and moisture conditions that affect management practices such as fertilizer, pesticide applications, and their impact as non-point pollution runoff. Since April of 2015, NASA's Soil Moisture Active Passive (SMAP) mission has retrieved soil moisture using L-band passive radiometric measurements at a 8 day repeat orbit with a swath of 1000 km that maps the Earth in 2-3 days depending on locations. Of particular interest to SMAP-based agricultural applications is a monitoring product that assesses the SMAP soil moisture in terms of probability percentiles for dry (drought) or wet (pluvial) conditions. SMAP observations do result in retrievals that are spatially and temporally discontinuous. Additionally, the short SMAP record length provides a statistical challenge in estimating a drought index and thus drought risk evaluations. In this presentation, we describe a SMAP drought index for the CONUS region based on near-surface soil moisture percentiles. Because the length of the SMAP data record is limited, we use a Bayesian conditional probability approach to extend the SMAP record back to 1979 based on simulated soil moisture of the same period from the Variable Infiltration Capacity (VIC) Land Surface Model (LSM), simulated by Princeton University. This is feasible because the VIC top soil layer (10 cm) is highly correlated with the SMAP 36 km passive microwave during 2015-2016, with more than half the CONUS grids having a cross-correlation greater than 0.6, and over 0.9 in many regions. Given the extended SMAP record, we construct an empirical probability distribution of near-surface soil moisture drought index showing severities similar to those used by the U.S. Drought Monitor (from D0-D4), for a specific SMAP observation. The analysis is done for each of the 8,150 SMAP grids covering the CONUS domain. Comparisons between the SMAP drought index and that from the VIC LSM are presented for selected recent drought events. Issues such as seasonality, robustness of the fitting, regions of poor SMAP-VIC correlations, and extensions to other areas will be discussed.

Determinants of health after hospital discharge: rationale and design of the Vanderbilt Inpatient Cohort Study (VICS)

PubMed Central

2014-01-01

Background The period following hospital discharge is a vulnerable time for patients when errors and poorly coordinated care are common. Suboptimal care transitions for patients admitted with cardiovascular conditions can contribute to readmission and other adverse health outcomes. Little research has examined the role of health literacy and other social determinants of health in predicting post-discharge outcomes. Methods The Vanderbilt Inpatient Cohort Study (VICS), funded by the National Institutes of Health, is a prospective longitudinal study of 3,000 patients hospitalized with acute coronary syndromes or acute decompensated heart failure. Enrollment began in October 2011 and is planned through October 2015. During hospitalization, a set of validated demographic, cognitive, psychological, social, behavioral, and functional measures are administered, and health status and comorbidities are assessed. Patients are interviewed by phone during the first week after discharge to assess the quality of hospital discharge, communication, and initial medication management. At approximately 30 and 90 days post-discharge, interviewers collect additional data on medication adherence, social support, functional status, quality of life, and health care utilization. Mortality will be determined with up to 3.5 years follow-up. Statistical models will examine hypothesized relationships of health literacy and other social determinants on medication management, functional status, quality of life, utilization, and mortality. In this paper, we describe recruitment, eligibility, follow-up, data collection, and analysis plans for VICS, as well as characteristics of the accruing patient cohort. Discussion This research will enhance understanding of how health literacy and other patient factors affect the quality of care transitions and outcomes after hospitalization. Findings will help inform the design of interventions to improve care transitions and post-discharge outcomes. PMID:24397292

DNA methylation of a PLPP3 MIR transposon-based enhancer promotes an osteogenic program in calcific aortic valve disease.

PubMed

Mkannez, Ghada; Gagné-Ouellet, Valérie; Nsaibia, Mohamed Jalloul; Boulanger, Marie-Chloé; Rosa, Mickael; Argaud, Deborah; Hadji, Fayez; Gaudreault, Nathalie; Rhéaume, Gabrielle; Bouchard, Luigi; Bossé, Yohan; Mathieu, Patrick

2018-05-02

Calcific aortic valve disease (CAVD) is characterized by the osteogenic transition of valve interstitial cells (VICs). In CAVD, lysophosphatidic acid (LysoPA), a lipid mediator with potent osteogenic activity, is produced in the aortic valve (AV) and is degraded by membrane-associated phospholipid phosphatases (PLPPs). We thus hypothesized that a dysregulation of PLPPs could participate to the osteogenic reprograming of VICs during CAVD. The expression of PLPPs was examined in human control and mineralized AVs and comprehensive analyses were performed to document the gene regulation and impact of PLPPs on the osteogenic transition of VICs. We found that PLPP3 gene and enzymatic activity were downregulated in mineralized AVs. Multidimensional gene profiling in 21 human AVs showed that expression of PLPP3 was inversely correlated with the level of 5-methylcytosine (5meC) located in an intronic mammalian interspersed repeat element (MIR). Bisulfite pyrosequencing in a larger series of 67 AVs confirmed that 5meC in intron 1 was increased by 2.2-fold in CAVD compared to control AVs. In isolated cells, epigenome editing with CRISPR-Cas9 system containing a deficient Cas9 fused with DNA methyltransferase (dCas9-DNMT) was used to increase 5meC in the intronic enhancer and showed that it reduced significantly the expression of PLPP3. Knockdown experiments showed that lower expression of PLPP3 in VICs promotes an osteogenic program. DNA methylation of a MIR-based enhancer downregulates the expression of PLPP3 and promotes the mineralization of the AV.

Comparing potential recharge estimates from three Land Surface Models across the Western US

PubMed Central

NIRAULA, REWATI; MEIXNER, THOMAS; AJAMI, HOORI; RODELL, MATTHEW; GOCHIS, DAVID; CASTRO, CHRISTOPHER L.

2018-01-01

Groundwater is a major source of water in the western US. However, there are limited recharge estimates available in this region due to the complexity of recharge processes and the challenge of direct observations. Land surface Models (LSMs) could be a valuable tool for estimating current recharge and projecting changes due to future climate change. In this study, simulations of three LSMs (Noah, Mosaic and VIC) obtained from the North American Land Data Assimilation System (NLDAS-2) are used to estimate potential recharge in the western US. Modeled recharge was compared with published recharge estimates for several aquifers in the region. Annual recharge to precipitation ratios across the study basins varied from 0.01–15% for Mosaic, 3.2–42% for Noah, and 6.7–31.8% for VIC simulations. Mosaic consistently underestimates recharge across all basins. Noah captures recharge reasonably well in wetter basins, but overestimates it in drier basins. VIC slightly overestimates recharge in drier basins and slightly underestimates it for wetter basins. While the average annual recharge values vary among the models, the models were consistent in identifying high and low recharge areas in the region. Models agree in seasonality of recharge occurring dominantly during the spring across the region. Overall, our results highlight that LSMs have the potential to capture the spatial and temporal patterns as well as seasonality of recharge at large scales. Therefore, LSMs (specifically VIC and Noah) can be used as a tool for estimating future recharge rates in data limited regions. PMID:29618845

MSIAC’s M&S Journal Online: Volume 2, September 2006

DTIC Science & Technology

2006-09-01

engineering fields, such as mechanical and electrical , rely on composability and interchangeability (substitutability) of components into workable systems...Terrain Data for the Vector-in-Command and Engineer Functional Area Models”, Technical Report GL-90-9, September 1990, USAEWES, Vicksburg 8. Frankenstein

Cataract Avoidance With Proton Therapy in Ocular Melanomas.

PubMed

Thariat, Juliette; Jacob, Sophie; Caujolle, Jean-Pierre; Maschi, Celia; Baillif, Stéphanie; Angellier, Gaelle; Mathis, Thibaud; Rosier, Laurence; Carnicer, Adela; Hérault, Joel; Salleron, Julia

2017-10-01

The lens is a radiosensitive organ. Any dose of cephalic irradiation can give rise to radiation-induced cataracts. Contrary to other forms of radiotherapy, proton therapy (PT) can spare all or part of the lens due to accurate dose deposition. We investigated whether a lens-sparing approach was relevant to avoid cataracts in uveal melanoma patients. Patients were referred for PT from onco-ophthalmologists of private and academic institutions. Patients without preexisting cataracts or implants were entered in a prospective database. Dose thresholds responsible for cataracts were investigated in volumes of lens or lens periphery. Lens opacifications and de novo vision-impairing cataracts (VICs) had biannual follow up by ophthalmologists blinded to lens dose. Correlations between dose-volume relationships and VICs were assessed using univariate/multivariate regressions. Between 1991 and 2015, 1696 uveal melanoma patients were consecutively treated with PT. After a median follow up of 48 months, 14.4% and 8.7% of patients had cataracts and VIC within median times of 19 and 28 months, respectively. Median values of mean lens and lens periphery doses were 1.1 (radiobiologically effective [RBE] dose in photon-equivalent grays [GyRBE]) and 6.5 GyRBE, respectively. The lens received no dose in 25% of the patients. At an irradiated lens volume of ≤5%, there was no significantly increased risk for VIC below a dose of 10 GyRBE. A lens-sparing approach is feasible and results not only in reduced need for cataract surgery but also in better fundus-based tumor control. Reassessment of radioprotection rules for lens dose thresholds may follow.

Effects of oxygen on biofilm formation and the AtlA autolysin of Streptococcus mutans.

PubMed

Ahn, Sang-Joon; Burne, Robert A

2007-09-01

The Streptococcus mutans atlA gene encodes an autolysin required for biofilm maturation and biogenesis of a normal cell surface. We found that the capacity to form biofilms by S. mutans, one of the principal causative agents of dental caries, was dramatically impaired by growth of the organism in an aerated environment and that cells exposed to oxygen displayed marked changes in surface protein profiles. Inactivation of the atlA gene alleviated repression of biofilm formation in the presence of oxygen. Also, the formation of long chains, a characteristic of AtlA-deficient strains, was less evident in cells grown with aeration. The SMu0629 gene is immediately upstream of atlA and encodes a product that contains a C-X-X-C motif, a characteristic of thiol-disulfide oxidoreductases. Inactivation of SMu0629 significantly reduced the levels of AtlA protein and led to resistance to autolysis. The SMu0629 mutant also displayed an enhanced capacity to form biofilms in the presence of oxygen compared to that of the parental strain. The expression of SMu0629 was shown to be under the control of the VicRK two-component system, which influences oxidative stress tolerance in S. mutans. Disruption of vicK also led to inhibition of processing of AtlA, and the mutant was hyperresistant to autolysis. When grown under aerobic conditions, the vicK mutant also showed significantly increased biofilm formation compared to strain UA159. This study illustrates the central role of AtlA and VicK in orchestrating growth on surfaces and envelope biogenesis in response to redox conditions.

Virtual Interactive Classroom: A New Technology for Distance Learning Developed

NASA Technical Reports Server (NTRS)

York, David W.; Babula, Maria

1999-01-01

The Virtual Interactive Classroom (VIC) allows Internet users, specifically students, to remotely control and access data from scientific equipment. This is a significant advantage to school systems that cannot afford experimental equipment, have Internet access, and are seeking to improve science and math scores with current resources. A VIC Development Lab was established at Lewis to demonstrate that scientific equipment can be controlled by remote users over the Internet. Current projects include a wind tunnel, a room camera, a science table, and a microscope.

A hydrological emulator for global applications – HE v1.0.0

DOE Office of Scientific and Technical Information (OSTI.GOV)

Liu, Yaling; Hejazi, Mohamad; Li, Hongyi

While global hydrological models (GHMs) are very useful in exploring water resources and interactions between the Earth and human systems, their use often requires numerous model inputs, complex model calibration, and high computation costs. To overcome these challenges, we construct an efficient open-source and ready-to-use hydrological emulator (HE) that can mimic complex GHMs at a range of spatial scales (e.g., basin, region, globe). More specifically, we construct both a lumped and a distributed scheme of the HE based on the monthly abcd model to explore the tradeoff between computational cost and model fidelity. Model predictability and computational efficiency are evaluatedmore » in simulating global runoff from 1971 to 2010 with both the lumped and distributed schemes. The results are compared against the runoff product from the widely used Variable Infiltration Capacity (VIC) model. Our evaluation indicates that the lumped and distributed schemes present comparable results regarding annual total quantity, spatial pattern, and temporal variation of the major water fluxes (e.g., total runoff, evapotranspiration) across the global 235 basins (e.g., correlation coefficient r between the annual total runoff from either of these two schemes and the VIC is > 0.96), except for several cold (e.g., Arctic, interior Tibet), dry (e.g., North Africa) and mountainous (e.g., Argentina) regions. Compared against the monthly total runoff product from the VIC (aggregated from daily runoff), the global mean Kling–Gupta efficiencies are 0.75 and 0.79 for the lumped and distributed schemes, respectively, with the distributed scheme better capturing spatial heterogeneity. Notably, the computation efficiency of the lumped scheme is 2 orders of magnitude higher than the distributed one and 7 orders more efficient than the VIC model. A case study of uncertainty analysis for the world's 16 basins with top annual streamflow is conducted using 100 000 model simulations, and it demonstrates the lumped scheme's extraordinary advantage in computational efficiency. Lastly, our results suggest that the revised lumped abcd model can serve as an efficient and reasonable HE for complex GHMs and is suitable for broad practical use, and the distributed scheme is also an efficient alternative if spatial heterogeneity is of more interest.« less

Molecular sled is an eleven-amino acid vehicle facilitating biochemical interactions via sliding components along DNA

DOE PAGES

Mangel, Walter F.; McGrath, William J.; Xiong, Kan; ...

2016-02-02

Recently, we showed the adenovirus proteinase interacts productively with its protein substrates in vitro and in vivo in nascent virus particles via one-dimensional diffusion along the viral DNA. The mechanism by which this occurs has heretofore been unknown. We show sliding of these proteins along DNA occurs on a new vehicle in molecular biology, a ‘molecular sled’ named pVIc. This 11-amino acid viral peptide binds to DNA independent of sequence. pVIc slides on DNA, exhibiting the fastest one-dimensional diffusion constant, 26±1.8 × 10 6 (bp) 2 s −1. pVIc is a ‘molecular sled,’ because it can slide heterologous cargos along DNA,more » for example, a streptavidin tetramer. Similar peptides, for example, from the C terminus of β-actin or NLSIII of the p53 protein, slide along DNA. Finally, characteristics of the ‘molecular sled’ in its milieu (virion, nucleus) have implications for how proteins in the nucleus of cells interact and imply a new form of biochemistry, one-dimensional biochemistry.« less

Development and implementation of an expert system to improve the control of nitrification and denitrification in the Vic wastewater treatment plant.

PubMed

Ribas, F; Rodríguez-Roda, I; Serrat, J; Clara, P; Comas, J

2008-05-01

Wastewater treatment plants employ various physical, chemical and biological processes to reduce pollutants from raw wastewater. One of the most important is the biological nitrogen removal process through nitrification and denitrification steps taking place in various sections of the biological reactor. One of the most extensively used configurations to achieve the biological nitrogen removal is an activated sludge system using oxidation ditch or extended aeration. To improve nitrogen removal in the wastewater treatment plant (WWTP) of Vic (Catalonia, NE Spain), the automatic aeration control system was complemented with an Expert System to always provide the most appropriate aeration or anoxia sequence based on the values of ammonium and nitrates given by an automatic analyzer. This article illustrates the development and implementation of this knowledge-based system within the framework of a Decision Support System, which performs SCADA functions. The paper also shows that the application of the decision support system in the Vic WWTP resulted in significant improvements to the biological nitrogen removal.

An Improved Wavefront Control Algorithm for Large Space Telescopes

NASA Technical Reports Server (NTRS)

Sidick, Erkin; Basinger, Scott A.; Redding, David C.

2008-01-01

Wavefront sensing and control is required throughout the mission lifecycle of large space telescopes such as James Webb Space Telescope (JWST). When an optic of such a telescope is controlled with both surface-deforming and rigid-body actuators, the sensitivity-matrix obtained from the exit pupil wavefront vector divided by the corresponding actuator command value can sometimes become singular due to difference in actuator types and in actuator command values. In this paper, we propose a simple approach for preventing a sensitivity-matrix from singularity. We also introduce a new "minimum-wavefront and optimal control compensator". It uses an optimal control gain matrix obtained by feeding back the actuator commands along with the measured or estimated wavefront phase information to the estimator, thus eliminating the actuator modes that are not observable in the wavefront sensing process.

Reusable Launch Vehicle Control In Multiple Time Scale Sliding Modes

NASA Technical Reports Server (NTRS)

Shtessel, Yuri; Hall, Charles; Jackson, Mark

2000-01-01

A reusable launch vehicle control problem during ascent is addressed via multiple-time scaled continuous sliding mode control. The proposed sliding mode controller utilizes a two-loop structure and provides robust, de-coupled tracking of both orientation angle command profiles and angular rate command profiles in the presence of bounded external disturbances and plant uncertainties. Sliding mode control causes the angular rate and orientation angle tracking error dynamics to be constrained to linear, de-coupled, homogeneous, and vector valued differential equations with desired eigenvalues placement. Overall stability of a two-loop control system is addressed. An optimal control allocation algorithm is designed that allocates torque commands into end-effector deflection commands, which are executed by the actuators. The dual-time scale sliding mode controller was designed for the X-33 technology demonstration sub-orbital launch vehicle in the launch mode. Simulation results show that the designed controller provides robust, accurate, de-coupled tracking of the orientation angle command profiles in presence of external disturbances and vehicle inertia uncertainties. This is a significant advancement in performance over that achieved with linear, gain scheduled control systems currently being used for launch vehicles.

Military Infectious Diseases Update on Vaccine Development

DTIC Science & Technology

2011-01-24

Research Program (MIDRP) Insect Vector ControlDiagnostics Prevention Treatment Infectious diseases adversely impact military operations. Vaccines...appropriate treatment and aids commanders in the field. Most militarily relevant infectious diseases are transmitted by biting insects and other...based Insect Repellent (1946) Vaccines Protectants Antiparasitic Drugs Research Effort Advanced Development Fielded Products Malaria Rapid

Displaying the results of three-dimensional analysis using GRAPE. Part one: vector graphics. [In FORTRAN for CDC 7600

DOE Office of Scientific and Technical Information (OSTI.GOV)

Brown, B.E.

1979-10-01

GRAPE is a display program for three-dimensional polygon and polyhedral models. It can produce line-drawing and continuous-tone black and white or color images in still frame or movie mode. The code was written specifically to be a post-processor for finite element and finite difference analyses. It runs on the CDC 7600 computer, and is compiled with the LLL FTN system. The allocation of storage is dynamic. There are presently three data paths into the code. The first is the binary inerface from the analyses codes and this with the other databases is described. The second data path is the SAMPPmore » format, and the last is the MOVIE format. The code structure is described first; then the commands are discussed in general terms to try to give the user some feel for what they do. The next section deals with the exact format of the commands by overlay. Then examples are given and discussed. Next, the various output options are covered. 57 figures. (RWR)« less

Fast food purchasing and access to fast food restaurants: a multilevel analysis of VicLANES

PubMed Central

Thornton, Lukar E; Bentley, Rebecca J; Kavanagh, Anne M

2009-01-01

Background While previous research on fast food access and purchasing has not found evidence of an association, these studies have had methodological problems including aggregation error, lack of specificity between the exposures and outcomes, and lack of adjustment for potential confounding. In this paper we attempt to address these methodological problems using data from the Victorian Lifestyle and Neighbourhood Environments Study (VicLANES) – a cross-sectional multilevel study conducted within metropolitan Melbourne, Australia in 2003. Methods The VicLANES data used in this analysis included 2547 participants from 49 census collector districts in metropolitan Melbourne, Australia. The outcome of interest was the total frequency of fast food purchased for consumption at home within the previous month (never, monthly and weekly) from five major fast food chains (Red Rooster, McDonalds, Kentucky Fried Chicken, Hungry Jacks and Pizza Hut). Three measures of fast food access were created: density and variety, defined as the number of fast food restaurants and the number of different fast food chains within 3 kilometres of road network distance respectively, and proximity defined as the road network distance to the closest fast food restaurant. Multilevel multinomial models were used to estimate the associations between fast food restaurant access and purchasing with never purchased as the reference category. Models were adjusted for confounders including determinants of demand (attitudes and tastes that influence food purchasing decisions) as well as individual and area socio-economic characteristics. Results Purchasing fast food on a monthly basis was related to the variety of fast food restaurants (odds ratio 1.13; 95% confidence interval 1.02 – 1.25) after adjusting for individual and area characteristics. Density and proximity were not found to be significant predictors of fast food purchasing after adjustment for individual socio-economic predictors. Conclusion Although we found an independent association between fast food purchasing and access to a wider variety of fast food restaurant, density and proximity were not significant predictors. The methods used in our study are an advance on previous analyses. PMID:19473503

Breath-hold [68Ga]DOTA-TOC PET/CT in neuroendocrine tumors: detection of additional lesions and effects on quantitative parameters.

PubMed

Zirnsak, Mariana; Bärwolf, Robert; Freesmeyer, Martin

2016-11-08

Respiratory motion during PET/CT acquisition generates artifacts in the form of breath-related blurring, which influences the lesion detectability and diagnostic accuracy. The goal of this study was to verify whether breath-hold [68Ga]DOTA-TOC PET/CT (bhPET) allows detection of additional foci compared to free-breathing PET/CT (fbPET), and to assess the impact of breath-holding on standard uptake values (SUV) and isocontoured volume (Vic40) in patients with neuroendocrine tumors (NET). Patients with NET (n=39) were included in this study. BhPET and fbPET characteristics of 96 lesions were compared, and correlated with standard contrast-enhanced (ce) CT and MRI for lesion verification. Quantitative parameters SUV (max and mean) and Vic40 were assessed for both methods and evaluated by linear regression and Spearman's correlation. The impact of lesion size, localization and time interval between investigations was also analyzed. bhPET identified one additional metastasis not seen at fbPET but visible at ceMRI. Another additional bhPET focus did not have a morphological correlate. At bhPET, the SUVmax and SUVmean proved significantly higher and the Vic40 significantly lower than at fbPET. Lesion size, localization and time intervals did not impact significantly on SUV or Vic40. Currently, routine use of breath-hold [68Ga]DOTA-TOC PET/CT cannot be recommended as only one additional lesion was identified. Therefore, bhPET has currently no indication in patients with NET. If technical improvements regarding PET/CT scanner sensitivity are available, bhPET should be reevaluated in the future.

A Method for Integrating Thrust-Vectoring and Actuated Forebody Strakes with Conventional Aerodynamic Controls on a High-Performance Fighter Airplane

NASA Technical Reports Server (NTRS)

Lallman, Frederick J.; Davidson, John B.; Murphy, Patrick C.

1998-01-01

A method, called pseudo controls, of integrating several airplane controls to achieve cooperative operation is presented. The method eliminates conflicting control motions, minimizes the number of feedback control gains, and reduces the complication of feedback gain schedules. The method is applied to the lateral/directional controls of a modified high-performance airplane. The airplane has a conventional set of aerodynamic controls, an experimental set of thrust-vectoring controls, and an experimental set of actuated forebody strakes. The experimental controls give the airplane additional control power for enhanced stability and maneuvering capabilities while flying over an expanded envelope, especially at high angles of attack. The flight controls are scheduled to generate independent body-axis control moments. These control moments are coordinated to produce stability-axis angular accelerations. Inertial coupling moments are compensated. Thrust-vectoring controls are engaged according to their effectiveness relative to that of the aerodynamic controls. Vane-relief logic removes steady and slowly varying commands from the thrust-vectoring controls to alleviate heating of the thrust turning devices. The actuated forebody strakes are engaged at high angles of attack. This report presents the forward-loop elements of a flight control system that positions the flight controls according to the desired stability-axis accelerations. This report does not include the generation of the required angular acceleration commands by means of pilot controls or the feedback of sensed airplane motions.

DC-magnetic field vector measurement

NASA Technical Reports Server (NTRS)

Schmidt, R.

1981-01-01

A magnetometer experiment was designed to determine the local magnetic field by measuring the total of the Earth's magnetic field and that of an unknown spacecraft. The measured field vector components are available to all onboard experiments via the Spacelab command and data management system. The experiment consists of two parts, an electronic box and the magnetic field sensor. The sensor includes three independent measuring flux-gate magnetometers, each measuring one component. The physical background is the nonlinearity of the B-H curve of a ferrite material. Two coils wound around a ferrite rod are necessary. One of them, a tank coil, pumps the ferrite rod at approximately 20 kilohertz. As a consequence of the nonlinearity, many harmonics can be produced. The second coil (i.e., the detection coil) resonates to the first harmonic. If an unknown dc or low-frequency magnetic field exists, the amplitude of the first harmonic is a measure for the unknown magnetic field. The voltages detected by the sensors are to be digitized and transferred to the command and data management system.

Spectral feature extraction of EEG signals and pattern recognition during mental tasks of 2-D cursor movements for BCI using SVM and ANN.

PubMed

Bascil, M Serdar; Tesneli, Ahmet Y; Temurtas, Feyzullah

2016-09-01

Brain computer interface (BCI) is a new communication way between man and machine. It identifies mental task patterns stored in electroencephalogram (EEG). So, it extracts brain electrical activities recorded by EEG and transforms them machine control commands. The main goal of BCI is to make available assistive environmental devices for paralyzed people such as computers and makes their life easier. This study deals with feature extraction and mental task pattern recognition on 2-D cursor control from EEG as offline analysis approach. The hemispherical power density changes are computed and compared on alpha-beta frequency bands with only mental imagination of cursor movements. First of all, power spectral density (PSD) features of EEG signals are extracted and high dimensional data reduced by principle component analysis (PCA) and independent component analysis (ICA) which are statistical algorithms. In the last stage, all features are classified with two types of support vector machine (SVM) which are linear and least squares (LS-SVM) and three different artificial neural network (ANN) structures which are learning vector quantization (LVQ), multilayer neural network (MLNN) and probabilistic neural network (PNN) and mental task patterns are successfully identified via k-fold cross validation technique.

Impact of Climate Change on Water Resources in the Guadalquivir River Basin

NASA Astrophysics Data System (ADS)

Yeste Donaire, P.; García-Valdecasas-Ojeda, M.; Góngora García, T. M.; Gámiz-Fortis, S. R.; Castro-Diez, Y.; Esteban-Parra, M. J.

2017-12-01

Climate change has lead to a decrease of precipitation and an increase of temperature in the Mediterranean Basin during the last fifty years. These changes will be more intense over the course of the 21thcentury according to global climate projections. As a consequence, water resources are expected to decrease, particularly in the Guadalquivir River Basin. This study focuses on the hydrological response of the Guadalquivir River Basin to the climate change. For this end, firstly, the implementation of the Variable Infiltration Capacity (VIC) model in the Basin was carried out. The VIC model was calibrated with a dataset of daily precipitation, temperature and streamflow for the period 1990-2000. Precipitation and temperature data were extracted from SPAIN02, a dataset that covers the Peninsular Spain at 0.11º of spatial resolution. Streamflow data were gathered for a representative subset of gauging stations in the basin. These data were provided by the Spanish Center for Public Work Experimentation and Study (CEDEX). Subsequently, the VIC model was validated for the period 2000-2005 in order to verify that the model outputs fit well with the observational data. After the validation of the VIC model for present climate, secondly, the effect of climate change on the Guadalquivir River Basin will be analyzed by developing several simulations of the streamflow for future climate. Precipitation and temperature data will be obtained in this case from future projections coming from high resolution (at 0.088º) simulations carried out with the Weather Research and Forecasting (WRF) model for the Iberian Peninsula. These last simulations will be driven under two different Representative Concentration Pathway (RCP) scenarios, RCP 4.5 and RCP 8.5 for the periods 2021-50 and 2071-2100. The first results of this work show that the VIC model outputs are in good agreement with the observed streamflow for both the calibration and validation periods. In the context of climate change, a generalized decrease in surface and subsurface water resources is expected in the Guadalquivir River Basin. All these results will be of interest for water policy makers and practitioners in the next decades. ACKNOWLEDGEMENTS: This work has been financed by the projects P11-RNM-7941 (Junta de Andalucía) and CGL2013-48539-R (MINECO-Spain, FEDER).

Scalable Vector Media-processors for Embedded Systems

DTIC Science & Technology

2002-05-01

Set Architecture for Multimedia “When you do the common things in life in an uncommon way, you will command the attention of the world.” George ...Bibliography [ABHS89] M. August, G. Brost , C. Hsiung, and C. Schiffleger. Cray X-MP: The Birth of a Super- computer. IEEE Computer, 22(1):45–52, January

In situ elasticity modulation with dynamic substrates to direct cell phenotype

PubMed Central

Kloxin, April M.; Benton, Julie A.; Anseth, Kristi S.

2009-01-01

Microenvironment elasticity influences critical cell functions such as differentiation, cytoskeletal organization, and process extension. Unfortunately, few materials allow elasticity modulation in real-time to probe its direct effect on these dynamic cellular processes. Here, a new approach is presented for the photochemical modulation of elasticity within the cell's microenvironment at any point in time. A photodegradable hydrogel was irradiated and degraded under cytocompatible conditions to generate a wide range of elastic moduli similar to soft tissues and characterized using rheometry and atomic force microscopy (AFM). The effect of the elastic modulus on valvular interstitial cell (VIC) activation into myofibroblasts was explored. In these studies, gradient samples were used to identify moduli that either promote or suppress VIC myofibroblastic activation. With this knowledge, VICs were cultured on a high modulus, activating hydrogel substrate, and uniquely, results show that decreasing the substrate modulus with irradiation reverses this activation, demonstrating that myofibroblasts can be de-activated solely by changing the modulus of the underlying substrate. This finding is important for the rational design of biomaterials for tissue regeneration and offers insight into fibrotic disease progression. These photodegradable hydrogels demonstrate the capability to both probe and direct cell function through dynamic changes in substrate elasticity. PMID:19788947

Application of Linear Discriminant Analysis in Dimensionality Reduction for Hand Motion Classification

NASA Astrophysics Data System (ADS)

Phinyomark, A.; Hu, H.; Phukpattaranont, P.; Limsakul, C.

2012-01-01

The classification of upper-limb movements based on surface electromyography (EMG) signals is an important issue in the control of assistive devices and rehabilitation systems. Increasing the number of EMG channels and features in order to increase the number of control commands can yield a high dimensional feature vector. To cope with the accuracy and computation problems associated with high dimensionality, it is commonplace to apply a processing step that transforms the data to a space of significantly lower dimensions with only a limited loss of useful information. Linear discriminant analysis (LDA) has been successfully applied as an EMG feature projection method. Recently, a number of extended LDA-based algorithms have been proposed, which are more competitive in terms of both classification accuracy and computational costs/times with classical LDA. This paper presents the findings of a comparative study of classical LDA and five extended LDA methods. From a quantitative comparison based on seven multi-feature sets, three extended LDA-based algorithms, consisting of uncorrelated LDA, orthogonal LDA and orthogonal fuzzy neighborhood discriminant analysis, produce better class separability when compared with a baseline system (without feature projection), principle component analysis (PCA), and classical LDA. Based on a 7-dimension time domain and time-scale feature vectors, these methods achieved respectively 95.2% and 93.2% classification accuracy by using a linear discriminant classifier.

Incorporating agricultural management into an earth system model for the Pacific Northwest region: Interactions between climate, hydrology, agriculture, and economics

NASA Astrophysics Data System (ADS)

Chinnayakanahalli, K.; Adam, J. C.; Stockle, C.; Nelson, R.; Brady, M.; Rajagopalan, K.; Barber, M. E.; Dinesh, S.; Malek, K.; Yorgey, G.; Kruger, C.; Marsh, T.; Yoder, J.

2011-12-01

For better management and decision making in the face of climate change, earth system models must explicitly account for natural resource and agricultural management activities. Including crop system, water management, and economic models into an earth system modeling framework can help in answering questions related to the impacts of climate change on irrigation water and crop productivity, how agricultural producers can adapt to anticipated climate change, and how agricultural practices can mitigate climate change. Herein we describe the coupling of the Variability Infiltration Capacity (VIC) land surface model, which solves the water and energy balances of the hydrologic cycle at regional scales, with a crop-growth model, CropSyst. This new model, VIC-CropSyst, is the land surface model that will be used in a new regional-scale model development project focused on the Pacific Northwest, termed BioEarth. Here we describe the VIC-CropSyst coupling process and its application over the Columbia River basin (CRB) using agricultural-specific land cover information. The Washington State Department of Agriculture (WSDA) and U. S. Department of Agriculture (USDA) cropland data layers were used to identify agricultural land use patterns, in which both irrigated and dry land crops were simulated. The VIC-CropSyst model was applied over the CRB for the historical period of 1976 - 2006 to establish a baseline for surface water availability, irrigation demand, and crop production. The model was then applied under future (2030s) climate change scenarios derived from statistically-downscaled Global Circulation Models output under two emission scenarios (A1B and B1). Differences between simulated future and historical irrigation demand, irrigation water availability, and crop production were used in an economics model to identify the most economically-viable future cropping pattern. The economics model was run under varying scenarios of regional growth, trade, water pricing, and water capacity providing a spectrum of possible future cropping patterns. The resulting cropping patterns were then used in VIC-CropSyst to quantify the impacts of climate change, economic, and water management scenarios on crop production, and water resources availability. This modeling framework provides opportunities to study the interactions between human activities and complex natural processes and is a valuable tool for inclusion in an earth system model with the goal of informing land use and water management.

Configuration management and automatic control of an augmentor wing aircraft with vectored thrust

NASA Technical Reports Server (NTRS)

Cicolani, L. S.; Sridhar, B.; Meyer, G.

1979-01-01

An advanced structure for automatic flight control logic for powered-lift aircraft operating in terminal areas is under investigation at Ames Research Center. This structure is based on acceleration control; acceleration commands are constructed as the sum of acceleration on the reference trajectory and a corrective feedback acceleration to regulate path tracking errors. The central element of the structure, termed a Trimmap, uses a model of the aircraft aerodynamic and engine forces to calculate the control settings required to generate the acceleration commands. This report describes the design criteria for the Trimmap and derives a Trimmap for Ames experimental augmentor wing jet STOL research aircraft.

Hydrological extremes and their agricultural impacts under a changing climate in Texas

NASA Astrophysics Data System (ADS)

Lee, K.; Gao, H.; Huang, M.; Sheffield, J.

2015-12-01

With the changing climate, hydrologic extremes (such as floods, droughts, and heat waves) are becoming more frequent and intensified. Such changes in extreme events are expected to affect agricultural production and food supplies. This study focuses on the State of Texas, which has the largest farm area and the highest value of livestock production in the U.S. The objectives are two-fold: First, to investigate the climatic impact on the occurrence of future hydrologic extreme events; and second, to evaluate the effects of the future extremes on agricultural production. The Variable Infiltration Capacity (VIC) model, which is calibrated and validated over Texas river basins during the historical period, is employed for this study. The VIC model is forced by the statistically downscaled climate projections from the Coupled Model Intercomparison Project Phase 5 (CMIP5) model ensembles at a spatial resolution of 1/8°. The CMIP5 projections contain four different scenarios in terms of Representative Concentration Pathway (RCP) (i.e. 2.6, 4.5, 6.0 and 8.5 w/m2). To carry out the analysis, VIC outputs forced by the CMIP5 model scenarios over three 30-year periods (1970-1999, 2020-2049 and 2070-2099) are first evaluated to identify how the frequency and the extent of the extreme events will be altered in the ten Texas major river basins. The results suggest that a significant increase in the number of extreme events will occur starting in the first half of the 21st century in Texas. Then, the effects of the predicted hydrologic extreme events on the irrigation water demand are investigated. It is found that future changes in water demand vary by crop type and location, with an east-to-west gradient. The results are expected to contribute to future water management and planning in Texas.

Maximum power extraction under different vector-control schemes and grid-synchronization strategy of a wind-driven Brushless Doubly-Fed Reluctance Generator.

PubMed

Mousa, Mohamed G; Allam, S M; Rashad, Essam M

2018-01-01

This paper proposes an advanced strategy to synchronize the wind-driven Brushless Doubly-Fed Reluctance Generator (BDFRG) to the grid-side terminals. The proposed strategy depends mainly upon determining the electrical angle of the grid voltage, θ v and using the same transformation matrix of both the power winding and grid sides to ensure that the generated power-winding voltage has the same phase-sequence of the grid-side voltage. On the other hand, the paper proposes a vector-control (power-winding flux orientation) technique for maximum wind-power extraction under two schemes summarized as; unity power-factor operation and minimum converter-current. Moreover, a soft-starting method is suggested to avoid the employed converter over-current. The first control scheme is achieved by adjusting the command power-winding reactive power at zero for a unity power-factor operation. However, the second scheme depends on setting the command d-axis control-winding current at zero to maximize the ratio of the generator electromagnetic-torque per the converter current. This enables the system to get a certain command torque under minimum converter current. A sample of the obtained simulation and experimental results is presented to check the effectiveness of the proposed control strategies. Copyright © 2017 ISA. Published by Elsevier Ltd. All rights reserved.

Full quaternion based finite-time cascade attitude control approach via pulse modulation synthesis for a spacecraft.

PubMed

Mazinan, A H; Pasand, M; Soltani, B

2015-09-01

In the aspect of further development of investigations in the area of spacecraft modeling and analysis of the control scheme, a new hybrid finite-time robust three-axis cascade attitude control approach is proposed via pulse modulation synthesis. The full quaternion based control approach proposed here is organized in association with both the inner and the outer closed loops. It is shown that the inner closed loop, which consists of the sliding mode finite-time control approach, the pulse width pulse frequency modulator, the control allocation and finally the dynamics of the spacecraft is realized to track the three-axis referenced commands of the angular velocities. The pulse width pulse frequency modulators are in fact employed in the inner closed loop to accommodate the control signals to a number of on-off thrusters, while the control allocation algorithm provides the commanded firing times for the reaction control thrusters in the overactuated spacecraft. Hereinafter, the outer closed loop, which consists of the proportional linear control approach and the kinematics of the spacecraft is correspondingly designed to deal with the attitude angles that are presented by quaternion vector. It should be noted that the main motivation of the present research is to realize a hybrid control method by using linear and nonlinear terms and to provide a reliable and robust control structure, which is able to track time varying three-axis referenced commands. Subsequently, a stability analysis is presented to verify the performance of the overall proposed cascade attitude control approach. To prove the effectiveness of the presented approach, a thorough investigation is presented compared to a number of recent corresponding benchmarks. Copyright © 2015 ISA. Published by Elsevier Ltd. All rights reserved.

Impact of Initial Condition Errors and Precipitation Forecast Bias on Drought Simulation and Prediction in the Huaihe River Basin

NASA Astrophysics Data System (ADS)

Xu, H.; Luo, L.; Wu, Z.

2016-12-01

Drought, regarded as one of the major disasters all over the world, is not always easy to detect and forecast. Hydrological models coupled with Numerical Weather Prediction (NWP) has become a relatively effective method for drought monitoring and prediction. The accuracy of hydrological initial condition (IC) and the skill of NWP precipitation forecast can both heavily affect the quality and skill of hydrological forecast. In the study, the Variable Infiltration Capacity (VIC) model and Global Environmental Multi-scale (GEM) model were used to investigate the roles of IC and NWP forecast accuracy on hydrological predictions. A rev-ESP type experiment was conducted for a number of drought events in the Huaihe river basin. The experiment suggests that errors in ICs indeed affect the drought simulations by VIC and thus the drought monitoring. Although errors introduced in the ICs diminish gradually, the influence sometimes can last beyond 12 months. Using the soil moisture anomaly percentage index (SMAPI) as the metric to measure drought severity for the study region, we are able to quantify that time scale of influence from IC ranges. The analysis shows that the time scale is directly related to the magnitude of the introduced IC range and the average precipitation intensity. In order to explore how systematic bias correction in GEM forecasted precipitation can affect precipitation and hydrological forecast, we then both used station and gridded observations to eliminate biases of forecasted data. Meanwhile, different precipitation inputs with corrected data during drought process were conducted by VIC to investigate the changes of drought simulations, thus demonstrated short-term rolling drought prediction using a better performed corrected precipitation forecast. There is a word limit on the length of the abstract. So make sure your abstract fits the requirement. If this version is too long, try to shorten it as much as you can.

Vectored Thrust Digital Flight Control for Crew Escape. Volume 2.

DTIC Science & Technology

1985-12-01

no. 24. Lecrique, J., A. Rault, M. Tessier and J.L. Testud (1978), - "Multivariable Regulation of a Thermal Power Plant Steam Generator," presented...and Extended Kalman Observers," presented at the Conf. Decision and Control, San Diego, CA. Testud , J.L. (1977), Commande Numerique Multivariable du

Methods, systems and apparatus for adjusting duty cycle of pulse width modulated (PWM) waveforms

DOEpatents

Gallegos-Lopez, Gabriel; Kinoshita, Michael H; Ransom, Ray M; Perisic, Milun

2013-05-21

Embodiments of the present invention relate to methods, systems and apparatus for controlling operation of a multi-phase machine in a vector controlled motor drive system when the multi-phase machine operates in an overmodulation region. The disclosed embodiments provide a mechanism for adjusting a duty cycle of PWM waveforms so that the correct phase voltage command signals are applied at the angle transitions. This can reduce variations/errors in the phase voltage command signals applied to the multi-phase machine so that phase current may be properly regulated thus reducing current/torque oscillation, which can in turn improve machine efficiency and performance, as well as utilization of the DC voltage source.

Longitudinal-control design approach for high-angle-of-attack aircraft

NASA Technical Reports Server (NTRS)

Ostroff, Aaron J.; Proffitt, Melissa S.

1993-01-01

This paper describes a control synthesis methodology that emphasizes a variable-gain output feedback technique that is applied to the longitudinal channel of a high-angle-of-attack aircraft. The aircraft is a modified F/A-18 aircraft with thrust-vectored controls. The flight regime covers a range up to a Mach number of 0.7; an altitude range from 15,000 to 35,000 ft; and an angle-of-attack (alpha) range up to 70 deg, which is deep into the poststall region. A brief overview is given of the variable-gain mathematical formulation as well as a description of the discrete control structure used for the feedback controller. This paper also presents an approximate design procedure with relationships for the optimal weights for the selected feedback control structure. These weights are selected to meet control design guidelines for high-alpha flight controls. Those guidelines that apply to the longitudinal-control design are also summarized. A unique approach is presented for the feed-forward command generator to obtain smooth transitions between load factor and alpha commands. Finally, representative linear analysis results and nonlinear batch simulation results are provided.

Single step purification of recombinant proteins using the metal ion-inducible autocleavage (MIIA) domain as linker for tag removal.

PubMed

Ibe, Susan; Schirrmeister, Jana; Zehner, Susanne

2015-08-20

For fast and easy purification, proteins are typically fused with an affinity tag, which often needs to be removed after purification. Here, we present a method for the removal of the affinity tag from the target protein in a single step protocol. The protein VIC_001052 of the coral pathogen Vibrio coralliilyticus ATCC BAA-450 contains a metal ion-inducible autocatalytic cleavage (MIIA) domain. Its coding sequence was inserted into an expression vector for the production of recombinant fusion proteins. Following, the target proteins MalE and mCherry were produced as MIIA-Strep fusion proteins in Escherichia coli. The target proteins could be separated from the MIIA-Strep part simply by the addition of calcium or manganese(II) ions within minutes. The cleavage is not affected in the pH range from 5.0 to 9.0 or at low temperatures (6°C). Autocleavage was also observed with immobilized protein on an affinity column. The protein yield was similar to that achieved with a conventional purification protocol. Copyright © 2015 Elsevier B.V. All rights reserved.

A manual for microcomputer image analysis

DOE Office of Scientific and Technical Information (OSTI.GOV)

Rich, P.M.; Ranken, D.M.; George, J.S.

1989-12-01

This manual is intended to serve three basic purposes: as a primer in microcomputer image analysis theory and techniques, as a guide to the use of IMAGE{copyright}, a public domain microcomputer program for image analysis, and as a stimulus to encourage programmers to develop microcomputer software suited for scientific use. Topics discussed include the principals of image processing and analysis, use of standard video for input and display, spatial measurement techniques, and the future of microcomputer image analysis. A complete reference guide that lists the commands for IMAGE is provided. IMAGE includes capabilities for digitization, input and output of images,more » hardware display lookup table control, editing, edge detection, histogram calculation, measurement along lines and curves, measurement of areas, examination of intensity values, output of analytical results, conversion between raster and vector formats, and region movement and rescaling. The control structure of IMAGE emphasizes efficiency, precision of measurement, and scientific utility. 18 refs., 18 figs., 2 tabs.« less

Guidance and navigation for rendezvous with an uncooperative target

NASA Astrophysics Data System (ADS)

Telaar, J.; Schlaile, C.; Sommer, J.

2018-06-01

This paper presents a guidance strategy for a rendezvous with an uncooperative target. In the applied design reference mission, a spiral approach is commanded ensuring a collision-free relative orbit due to e/i-vector separation. The dimensions of the relative orbit are successively reduced by Δv commands which at the same time improve the observability of the relative state. The navigation is based on line-of-sight measurements. The relative state is estimated by an extended Kalman filter (EKF). The performance of this guidance and navigation strategy is demonstrated by extensive Monte Carlo simulations taking into account all major uncertainties like measurement errors, Δv execution errors, and differential drag.

Parsley: a Command-Line Parser for Astronomical Applications

NASA Astrophysics Data System (ADS)

Deich, William

Parsley is a sophisticated keyword + value parser, packaged as a library of routines that offers an easy method for providing command-line arguments to programs. It makes it easy for the user to enter values, and it makes it easy for the programmer to collect and validate the user's entries. Parsley is tuned for astronomical applications: for example, dates entered in Julian, Modified Julian, calendar, or several other formats are all recognized without special effort by the user or by the programmer; angles can be entered using decimal degrees or dd:mm:ss; time-like intervals as decimal hours, hh:mm:ss, or a variety of other units. Vectors of data are accepted as readily as scalars.

Antibacterial effects of Traditional Chinese Medicine monomers against Streptococcus pneumoniae via inhibiting pneumococcal histidine kinase (VicK).

PubMed

Zhang, Shuai; Wang, Jianmin; Xu, Wenchun; Liu, Yusi; Wang, Wei; Wu, Kaifeng; Wang, Zhe; Zhang, Xuemei

2015-01-01

Two-component systems (TCSs) have the potential to be an effective target of the antimicrobials, and thus received much attention in recent years. VicK/VicR is one of TCSs in Streptococcus pneumoniae (S. pneumoniae), which is essential for pneumococcal survival. We have previously obtained several Traditional Chinese Medicine monomers using a computer-based screening. In this study, either alone or in combination with penicillin, their antimicrobial activities were evaluated based on in vivo and in vitro assays. The results showed that the MICs of 5'-(Methylthio)-5'-deoxyadenosine, octanal 2, 4-dinitrophenylhydrazone, deoxyshikonin, kavahin, and dodecyl gallate against S. pneumoniae were 37.1, 38.5, 17, 68.5, and 21 μg/mL, respectively. Time-killing assays showed that these compounds elicited bactericidal effects against S. pneumoniae D39 strain, which led to a 6-log reduction in CFU after exposure to compounds at four times of the MIC for 24 h. The five compounds inhibited the growth of Streptococcus pyogenes, Streptococcus mitis, Streptococcus mutans or Streptococcus pseudopneumoniae, meanwhile, deoxyshikonin and dodecyl gallate displayed strong inhibitory activities against Staphylococcus aureus. These compounds showed no obvious cytotoxicity effects on Vero cells. Survival time of the mice infected by S. pneumoniae strains was prolonged by the treatment with the compounds. Importantly, all of the five compounds exerted antimicrobial effects against multidrug-resistant clinical strains of S. pneumoniae. Moreover, even at sub-MIC concentration, they inhibited cell division and biofilm formation. The five compounds all have enhancement effect on penicillin. Deoxyshikonin and dodecyl gallate showed significantly synergic antimicrobial activity with penicillin in vivo and in vitro, and effectively reduced nasopharyngeal and lung colonization caused by different penicillin-resistant pneumococcal serotypes. In addition, the two compounds also showed synergic antimicrobial activity with erythromycin and tetracycline. Taken together, our results suggest that these novel VicK inhibitors may be promising compounds against the pneumococcus, including penicillin-resistant strains.

Thailand Momentum on Policy and Practice in Local Legislation on Dengue Vector Control

PubMed Central

Bhumiratana, Adisak; Intarapuk, Apiradee; Chujun, Suriyo; Kaewwaen, Wuthichai; Sorosjinda-Nunthawarasilp, Prapa; Koyadun, Surachart

2014-01-01

Over a past decade, an administrative decentralization model, adopted for local administration development in Thailand, is replacing the prior centralized (top-down) command system. The change offers challenges to local governmental agencies and other public health agencies at all the ministerial, regional, and provincial levels. A public health regulatory and legislative framework for dengue vector control by local governmental agencies is a national topic of interest because dengue control program has been integrated into healthcare services at the provincial level and also has been given priority in health plans of local governmental agencies. The enabling environments of local administrations are unique, so this critical review focuses on the authority of local governmental agencies responsible for disease prevention and control and on the functioning of local legislation with respect to dengue vector control and practices. PMID:24799896

Effect of year-to-year variability of leaf area index on variable infiltration capacity model performance and simulation of streamflow during drought

NASA Astrophysics Data System (ADS)

Tesemma, Z. K.; Wei, Y.; Peel, M. C.; Western, A. W.

2014-09-01

This study assessed the effect of using observed monthly leaf area index (LAI) on hydrologic model performance and the simulation of streamflow during drought using the variable infiltration capacity (VIC) hydrological model in the Goulburn-Broken catchment of Australia, which has heterogeneous vegetation, soil and climate zones. VIC was calibrated with both observed monthly LAI and long-term mean monthly LAI, which were derived from the Global Land Surface Satellite (GLASS) observed monthly LAI dataset covering the period from 1982 to 2012. The model performance under wet and dry climates for the two different LAI inputs was assessed using three criteria, the classical Nash-Sutcliffe efficiency, the logarithm transformed flow Nash-Sutcliffe efficiency and the percentage bias. Finally, the percentage deviation of the simulated monthly streamflow using the observed monthly LAI from simulated streamflow using long-term mean monthly LAI was computed. The VIC model predicted monthly streamflow in the selected sub-catchments with model efficiencies ranging from 61.5 to 95.9% during calibration (1982-1997) and 59 to 92.4% during validation (1998-2012). Our results suggest systematic improvements from 4 to 25% in the Nash-Sutcliffe efficiency in pasture dominated catchments when the VIC model was calibrated with the observed monthly LAI instead of the long-term mean monthly LAI. There was limited systematic improvement in tree dominated catchments. The results also suggest that the model overestimation or underestimation of streamflow during wet and dry periods can be reduced to some extent by including the year-to-year variability of LAI in the model, thus reflecting the responses of vegetation to fluctuations in climate and other factors. Hence, the year-to-year variability in LAI should not be neglected; rather it should be included in model calibration as well as simulation of monthly water balance.

The effect of year-to-year variability of leaf area index on Variable Infiltration Capacity model performance and simulation of runoff

NASA Astrophysics Data System (ADS)

Tesemma, Z. K.; Wei, Y.; Peel, M. C.; Western, A. W.

2015-09-01

This study assessed the effect of using observed monthly leaf area index (LAI) on hydrological model performance and the simulation of runoff using the Variable Infiltration Capacity (VIC) hydrological model in the Goulburn-Broken catchment of Australia, which has heterogeneous vegetation, soil and climate zones. VIC was calibrated with both observed monthly LAI and long-term mean monthly LAI, which were derived from the Global Land Surface Satellite (GLASS) leaf area index dataset covering the period from 1982 to 2012. The model performance under wet and dry climates for the two different LAI inputs was assessed using three criteria, the classical Nash-Sutcliffe efficiency, the logarithm transformed flow Nash-Sutcliffe efficiency and the percentage bias. Finally, the deviation of the simulated monthly runoff using the observed monthly LAI from simulated runoff using long-term mean monthly LAI was computed. The VIC model predicted monthly runoff in the selected sub-catchments with model efficiencies ranging from 61.5% to 95.9% during calibration (1982-1997) and 59% to 92.4% during validation (1998-2012). Our results suggest systematic improvements, from 4% to 25% in Nash-Sutcliffe efficiency, in sparsely forested sub-catchments when the VIC model was calibrated with observed monthly LAI instead of long-term mean monthly LAI. There was limited systematic improvement in tree dominated sub-catchments. The results also suggest that the model overestimation or underestimation of runoff during wet and dry periods can be reduced to 25 mm and 35 mm respectively by including the year-to-year variability of LAI in the model, thus reflecting the responses of vegetation to fluctuations in climate and other factors. Hence, the year-to-year variability in LAI should not be neglected; rather it should be included in model calibration as well as simulation of monthly water balance.

Improving gridded snow water equivalent products in British Columbia, Canada: multi-source data fusion by neural network models

NASA Astrophysics Data System (ADS)

Snauffer, Andrew M.; Hsieh, William W.; Cannon, Alex J.; Schnorbus, Markus A.

2018-03-01

Estimates of surface snow water equivalent (SWE) in mixed alpine environments with seasonal melts are particularly difficult in areas of high vegetation density, topographic relief, and snow accumulations. These three confounding factors dominate much of the province of British Columbia (BC), Canada. An artificial neural network (ANN) was created using as predictors six gridded SWE products previously evaluated for BC. Relevant spatiotemporal covariates were also included as predictors, and observations from manual snow surveys at stations located throughout BC were used as target data. Mean absolute errors (MAEs) and interannual correlations for April surveys were found using cross-validation. The ANN using the three best-performing SWE products (ANN3) had the lowest mean station MAE across the province. ANN3 outperformed each product as well as product means and multiple linear regression (MLR) models in all of BC's five physiographic regions except for the BC Plains. Subsequent comparisons with predictions generated by the Variable Infiltration Capacity (VIC) hydrologic model found ANN3 to better estimate SWE over the VIC domain and within most regions. The superior performance of ANN3 over the individual products, product means, MLR, and VIC was found to be statistically significant across the province.

A neural network simulating human reach-grasp coordination by continuous updating of vector positioning commands.

PubMed

Ulloa, Antonio; Bullock, Daniel

2003-10-01

We developed a neural network model to simulate temporal coordination of human reaching and grasping under variable initial grip apertures and perturbations of object size and object location/orientation. The proposed model computes reach-grasp trajectories by continuously updating vector positioning commands. The model hypotheses are (1) hand/wrist transport, grip aperture, and hand orientation control modules are coupled by a gating signal that fosters synchronous completion of the three sub-goals. (2) Coupling from transport and orientation velocities to aperture control causes maximum grip apertures that scale with these velocities and exceed object size. (3) Part of the aperture trajectory is attributable to an aperture-reducing passive biomechanical effect that is stronger for larger apertures. (4) Discrepancies between internal representations of targets partially inhibit the gating signal, leading to movement time increases that compensate for perturbations. Simulations of the model replicate key features of human reach-grasp kinematics observed under three experimental protocols. Our results indicate that no precomputation of component movement times is necessary for online temporal coordination of the components of reaching and grasping.

Impact of Climate Change on Mercury Transport along the Carson River-Lahontan Reservoir System

NASA Astrophysics Data System (ADS)

Flickinger, A.; Carroll, R. W. H.; Warwick, J. J.; Schumer, R.

2014-12-01

Historic mining practices have left the Carson River and Lahontan Reservoir (CRLR) system contaminated with high levels of mercury (Hg). Hg levels in Lahontan Reservoir planktivorous and predatory fish exceed federal consumption limits. Inputs of Hg to the system are mainly a result of erosion during high flow and diffusion from sediment during low flow, and the relationships between streamflow and both mercury transport and bioaccumulation are non-linear. The United States Bureau of Reclamation has produced future streamflow estimates for 2000-2099 using 112 CMIP3 climate projections and the Variable Infiltration Capacity (VIC) model. VIC results suggest that the hydrology of the system is likely to experience higher frequencies of both high and low extreme flows, and the monthly averages of future flows are expected to be higher in the winter and lower in the summer compared to observed flows. VIC daily streamflow estimates are biased-corrected using an empirical cumulative distribution function to match observed data over the historic period of 1950-1999. Future reservoir stage and outflows are modeled assuming reservoir operations are a function of river/canal inflows, previous reservoir stage and downstream agricultural demands. VIC and reservoir flows drive the CRLR Hg transport model (RIVMOD, WASP5, and MERC4). Daily output for both total and dissolved inorganic Hg and methylmercury (MeHg) are averaged at the decadal timescale to assess changes and uncertainty in predicted spatial and temporal Hg species water column concentrations as a function of altered hydrology with respect to changing climate. Future research will use CRLR output in a bioenergetics and Hg mass balance model for Sacramento blackfish (Orthodon microlepidotus), a filter feeding cyprinid found in Lahontan Reservoir. These future simulations will help to assess possible changes in ecosystem health with respect to hydrologic conditions and associated changes to Hg transport.

Pressure spectra from single-snapshot tomographic PIV

NASA Astrophysics Data System (ADS)

Schneiders, Jan F. G.; Avallone, Francesco; Pröbsting, Stefan; Ragni, Daniele; Scarano, Fulvio

2018-03-01

The power spectral density and coherence of temporal pressure fluctuations are obtained from low-repetition-rate tomographic PIV measurements. This is achieved by extension of recent single-snapshot pressure evaluation techniques based upon the Taylor's hypothesis (TH) of frozen turbulence and vortex-in-cell (VIC) simulation. Finite time marching of the measured instantaneous velocity fields is performed using TH and VIC. Pressure is calculated from the resulting velocity time series. Because of the theoretical limitations, the finite time marching can be performed until the measured flow structures are convected out of the measurement volume. This provides a lower limit of resolvable frequency range. An upper limit is given by the spatial resolution of the measurements. Finite time-marching approaches are applied to low-repetition-rate tomographic PIV data of the flow past a straight trailing edge at 10 m/s. Reference results of the power spectral density and coherence are obtained from surface pressure transducers. In addition, the results are compared to state-of-the-art experimental data obtained from time-resolved tomographic PIV performed at 10 kHz. The time-resolved approach suffers from low spatial resolution and limited maximum acquisition frequency because of hardware limitations. Additionally, these approaches strongly depend upon the time kernel length chosen for pressure evaluation. On the other hand, the finite time-marching approaches make use of low-repetition-rate tomographic PIV measurements that offer higher spatial resolution. Consequently, increased accuracy of the power spectral density and coherence of pressure fluctuations are obtained in the high-frequency range, in comparison to the time-resolved measurements. The approaches based on TH and VIC are found to perform similarly in the high-frequency range. At lower frequencies, TH is found to underestimate coherence and intensity of the pressure fluctuations in comparison to time-resolved PIV and the microphone reference data. The VIC-based approach, on the other hand, returns results on the order of the reference.

A theoretical study of the hydrogen bonding between the vic-, cis- and trans-C 2H 2F 2 isomers and hydrogen fluoride

NASA Astrophysics Data System (ADS)

Rusu, Victor H.; da Silva, João Bosco P.; Ramos, Mozart N.

2009-04-01

MP2/6-31++G(d,p) and B3LYP/6-31++G(d,p) theoretical calculations have been employed to investigate the hydrogen bonding formation involving the vic-, cis- and trans-C 2H 2F 2 isomers and hydrogen fluoride. Our calculations have revealed for each isomer the preferential existence of two possible hydrogen-bonded complexes: a non-cyclic complex and a cyclic complex. For all the three isomers the binding energies for the non-cyclic and cyclic hydrogen complexes are essentially equal using both the MP2 and B3LYP calculations, being that the cyclic structure is slightly more stable. For instance, the binding energies including BSSE and ZPE corrections for the non-cyclic and cyclic structures of cis-C 2H 2F···HF are 8.7 and 9.0 kJ mol -1, respectively, using B3LYP calculations. The cyclic complex formation reduces the polarity, in contrast to what occurs with the non-cyclic complex. This result is more accentuated in vic-C 2H 2F 2···HF. In this latter, Δ μ(cyclic) is -3.07 D, whereas Δ μ(non-cyclic) is +1.92 D using B3LYP calculations. Their corresponding MP2 values are +0.44 D and -1.89 D, respectively. As expected, the complexation produces an H sbnd F stretching frequency downward shift, whereas its IR intensity is enhanced. On the other hand, the vibrational modes of the vic-, cis- and trans-C 2H 2F 2 isomers are little affected by complexation. The new vibrational modes due to hydrogen bonding formation show several interesting features, in particular the HF bending modes which are pure rotations in the free molecule.

Reusable Launch Vehicle Control in Multiple Time Scale Sliding Modes

NASA Technical Reports Server (NTRS)

Shtessel, Yuri

1999-01-01

A reusable launch vehicle control problem during ascent is addressed via multiple-time scaled continuous sliding mode control. The proposed sliding mode controller utilizes a two-loop structure and provides robust, de-coupled tracking of both orientation angle command profiles and angular rate command profiles in the presence of bounded external disturbances and plant uncertainties. Sliding mode control causes the angular rate and orientation angle tracking error dynamics to be constrained to linear, de-coupled, homogeneous, and vector valued differential equations with desired eigenvalues placement. The dual-time scale sliding mode controller was designed for the X-33 technology demonstration sub-orbital launch vehicle in the launch mode. 6DOF simulation results show that the designed controller provides robust, accurate, de-coupled tracking of the orientation angle command profiles in presence of external disturbances and vehicle inertia uncertainties. It creates possibility to operate the X-33 vehicle in an aircraft-like mode with reduced pre-launch adjustment of the control system.

Modeling Lake Storage Dynamics to support Arctic Boreal Vulnerability Experiment (ABoVE)

NASA Astrophysics Data System (ADS)

Vimal, S.; Lettenmaier, D. P.; Smith, L. C.; Smith, S.; Bowling, L. C.; Pavelsky, T.

2017-12-01

The Arctic and Boreal Zone (ABZ) of Canada and Alaska includes vast areas of permafrost, lakes, and wetlands. Permafrost thawing in this area is expected to increase due to the projected rise of temperature caused by climate change. Over the long term, this may reduce overall surface water area, but in the near-term, the opposite is being observed, with rising paludification (lake/wetland expansion). One element of NASA's ABoVE field experiment is observations of lake and wetland extent and surface elevations using NASA's AirSWOT airborne interferometric radar, accompanied by a high-resolution camera. One use of the WSE retrievals will be to constrain model estimates of lake storage dynamics. Here, we compare predictions using the lake dynamics algorithm within the Variable Infiltration Capacity (VIC) land surface scheme. The VIC lake algorithm includes representation of sub-grid topography, where the depth and area of seasonally-flooded areas are modeled as a function of topographic wetness index, basin area, and slope. The topography data used is from a new global digital elevation model, MERIT-DEM. We initially set up VIC at sites with varying permafrost conditions (i.e., no permafrost, discontinuous, continuous) in Saskatoon and Yellowknife, Canada, and Toolik Lake, Alaska. We constrained the uncalibrated model with the WSE at the time of the first ABoVE flight, and quantified the model's ability to predict WSE and ΔWSE during the time of the second flight. Finally, we evaluated the sensitivity of the VIC-lakes model and compared the three permafrost conditions. Our results quantify the sensitivity of surface water to permafrost state across the target sites. Furthermore, our evaluation of the lake modeling framework contributes to the modeling and mapping framework for lake and reservoir storage change evaluation globally as part of the SWOT mission, planned for launch in 2021.

Mariner Mars 1971 attitude control subsystem

NASA Technical Reports Server (NTRS)

Edmunds, R. S.

1974-01-01

The Mariner Mars 1971 attitude control subsystem (ACS) is discussed. It is comprised of a sun sensor set, a Canopus tracker, an inertial reference unit, two cold gas reaction control assemblies, two rocket engine gimbal actuators, and an attitude control electronics unit. The subsystem has the following eight operating modes: (1) launch, (2) sun acquisition, (3) roll search, (4) celestial cruise, (5) all-axes inertial, (6) roll inertial, (7) commanded turn, and (8) thrust vector control. In the celestial cruise mode, the position control is held to plus or minus 0.25 deg. Commanded turn rates are plus or minus 0.18 deg/s. The attitude control logic in conjunction with command inputs from other spacecraft subsystems establishes the ACS operating mode. The logic utilizes Sun and Canopus acquisition signals generated within the ACS to perform automatic mode switching so that dependence of ground control is minimized when operating in the sun acquisition, roll search, and celestial cruise modes. The total ACS weight is 65.7 lb, and includes 5.4 lb of nitrogen gas. Total power requirements vary from 9 W for the celestial cruise mode to 54 W for the commanded turn mode.

Displaying Force and Torque of A Manipulator

NASA Technical Reports Server (NTRS)

Bejczy, A. K.; Dotson, R. S.; Primus, H. C.

1984-01-01

Display combines bar charts, vector diagrams, and numerical values to inform operator of forces and torques exerted by end effector of manipulator. On voice or keyboard command, eight-channel strip-chart recorder traces force and torque components and claw position of raw measurements from eight strain gage sensors in end effector. Especially helpful when operator's view of end effector is obscured.

The high speed buffer board: A SAIL EIA-485 communications accelerator card for the vector measuring current meter

NASA Astrophysics Data System (ADS)

Singer, Robin; Butler, Douglas M.

1990-07-01

A High Speed Buffer Board (HSBB) was developed for the Vector Measuring Current Meter (VMCM) to implement the transmission of data at 9600 baud over an EIA-485 link. The HSBB significantly extends the VMCM communication functionality, which was previously limited to 300 baud transmission via 20mA current loop or FSK telemetry. The increased speed allows rapid sampling of a large number of current meters on a common cable and the EIA-485 circuitry, which was designed for low power operation, provides a useful multipoint communication method for data transmission over long cable lengths. SAIL protocol (IEEE 997) was utilized to coordinate data transfer by the instruments on a common link. An MC68HC11 microcontroller resides in the VMCM, buffering data it receives at 300 baud from the VMCM UART. In response to a jumper selectable SAIL address, the MC68HC11 offloads the data 9600 baud via EIA-485 to the SAIL controller. Synchronous data collection from many instruments is ensured by the SAIL synoptic set command and an embedded resynchronization/reset command. The low power consumption allows deployments of six months or more with a standard VMCM battery stack.

Controlling Attitude of a Solar-Sail Spacecraft Using Vanes

NASA Technical Reports Server (NTRS)

Mettler, Edward; Acikmese, Ahmet; Ploen, Scott

2006-01-01

A paper discusses a concept for controlling the attitude and thrust vector of a three-axis stabilized Solar Sail spacecraft using only four single degree-of-freedom articulated spar-tip vanes. The vanes, at the corners of the sail, would be turned to commanded angles about the diagonals of the square sail. Commands would be generated by an adaptive controller that would track a given trajectory while rejecting effects of such disturbance torques as those attributable to offsets between the center of pressure on the sail and the center of mass. The controller would include a standard proportional + derivative part, a feedforward part, and a dynamic component that would act like a generalized integrator. The controller would globally track reference signals, and in the presence of such control-actuator constraints as saturation and delay, the controller would utilize strategies to cancel or reduce their effects. The control scheme would be embodied in a robust, nonlinear algorithm that would allocate torques among the vanes, always finding a stable solution arbitrarily close to the global optimum solution of the control effort allocation problem. The solution would include an acceptably small angle, slow limit-cycle oscillation of the vanes, while providing overall thrust vector pointing stability and performance.

Alternative Attitude Commanding and Control for Precise Spacecraft Landing

NASA Technical Reports Server (NTRS)

Singh, Gurkirpal

2004-01-01

A report proposes an alternative method of control for precision landing on a remote planet. In the traditional method, the attitude of a spacecraft is required to track a commanded translational acceleration vector, which is generated at each time step by solving a two-point boundary value problem. No requirement of continuity is imposed on the acceleration. The translational acceleration does not necessarily vary smoothly. Tracking of a non-smooth acceleration causes the vehicle attitude to exhibit undesirable transients and poor pointing stability behavior. In the alternative method, the two-point boundary value problem is not solved at each time step. A smooth reference position profile is computed. The profile is recomputed only when the control errors get sufficiently large. The nominal attitude is still required to track the smooth reference acceleration command. A steering logic is proposed that controls the position and velocity errors about the reference profile by perturbing the attitude slightly about the nominal attitude. The overall pointing behavior is therefore smooth, greatly reducing the degree of pointing instability.

NCEP/NLDAS Drought Monitoring and Prediction

NASA Astrophysics Data System (ADS)

Xia, Y.; Ek, M.; Wood, E.; Luo, L.; Sheffield, J.; Lettenmaier, D.; Livneh, B.; Cosgrove, B.; Mocko, D.; Meng, J.; Wei, H.; Restrepo, P.; Schaake, J.; Mo, K.

2009-05-01

The NCEP Environmental Modeling Center (EMC) collaborated with its CPPA (Climate Prediction Program of the Americas) partners to develop a North American Land Data Assimilation System (NLDAS, http://www.emc.ncep.noaa.gov/mmb/nldas) to monitor and predict the drought over the Continental United States (CONUS). The realtime NLDAS drought monitor, executed daily at NCEP/EMC, including daily, weekly and monthly anomaly and percentile of six fields (soil moisture, snow water equivalent, total runoff, streamflow, evaporation, precipitation) outputted from four land surface models (Noah, Mosaic, SAC, and VIC) on a common 1/8th degree grid using common hourly land surface forcing. The non-precipitation surface forcing is derived from NCEP's retrospective and realtime North American Regional Reanalysis System (NARR). The precipitation forcing is anchored to a daily gauge-only precipitation analysis over CONUS that applies a Parameter-elevation Regressions on Independent Slopes Model (PRISM) correction. This daily precipitation analysis is then temporally disaggregated to hourly precipitation amounts using radar and satellite precipitation. The NARR- based surface downward solar radiation is bias-corrected using seven years (1997-2004) of GOES satellite- derived solar radiation retrievals. The uncoupled ensemble seasonal drought prediction utilizes the following three independent approaches for generating downscaled ensemble seasonal forecasts of surface forcing: (1) Ensemble Streamflow Prediction, (2) CPC Official Seasonal Climate Outlook, and (3) NCEP CFS ensemble dynamical model prediction. For each of these three approaches, twenty ensemble members of forcing realizations are generated using a Bayesian merging algorithm developed by Princeton University. The three forcing methods are then used to drive the VIC model in seasonal prediction mode over thirteen large river basins that together span the CONUS domain. One to nine month ensemble seasonal prediction products such as air temperature, precipitation, soil moisture, snowpack, total runoff, evaporation and streamflow are derived for each forcing approach. The anomalies and percentiles of the predicted products for each approach may be used for CONUS drought prediction. This system is executed at the beginning of each month and distributes its products by the 10th of each month. The prediction products are evaluated using corresponding monitoring products for the VIC model and are compared with the prediction products from other research groups (e.g., University of Washington at Seattle, NASA Goddard) in the CONUS.

OMV: A simplified mathematical model of the orbital maneuvering vehicle

NASA Technical Reports Server (NTRS)

Teoh, W.

1984-01-01

A model of the orbital maneuvering vehicle (OMV) is presented which contains several simplications. A set of hand controller signals may be used to control the motion of the OMV. Model verification is carried out using a sequence of tests. The dynamic variables generated by the model are compared, whenever possible, with the corresponding analytical variables. The results of the tests show conclusively that the present model is behaving correctly. Further, this model interfaces properly with the state vector transformation module (SVX) developed previously. Correct command sentence sequences are generated by the OMV and and SVX system, and these command sequences can be used to drive the flat floor simulation system at MSFC.

Control System of a Three DOF Spacecraft Simulator by Vectorable Thrusters and Control Moment Gyros

DTIC Science & Technology

2006-12-01

1 s 1 s -K- -K- -K- -K- -K- -K- -K- -K- -K- 2 STATE 1 REF Tc urel Fx Fy Figure 42. Controller SIMULINK Model As an initial step in the...f1c a1c a1True a2c a2True f1act Thruster 1 Firing Logic [DelTrue] [a1True] [a2True] [DelTrue] Fx Fy T theta del F1c a1c F2c a2c Tcmg fcn Tc deltrue...cmgdd command CMG Steering Logic 3 theta 2 act_fb 1 uCOMMANDED Fx Fy Tc 52 to slew and fire independently, MSGCMG position is used to generate a

Breathing motion compensated reconstruction for C-arm cone beam CT imaging: initial experience based on animal data

NASA Astrophysics Data System (ADS)

Schäfer, D.; Lin, M.; Rao, P. P.; Loffroy, R.; Liapi, E.; Noordhoek, N.; Eshuis, P.; Radaelli, A.; Grass, M.; Geschwind, J.-F. H.

2012-03-01

C-arm based tomographic 3D imaging is applied in an increasing number of minimal invasive procedures. Due to the limited acquisition speed for a complete projection data set required for tomographic reconstruction, breathing motion is a potential source of artifacts. This is the case for patients who cannot comply breathing commands (e.g. due to anesthesia). Intra-scan motion estimation and compensation is required. Here, a scheme for projection based local breathing motion estimation is combined with an anatomy adapted interpolation strategy and subsequent motion compensated filtered back projection. The breathing motion vector is measured as a displacement vector on the projections of a tomographic short scan acquisition using the diaphragm as a landmark. Scaling of the displacement to the acquisition iso-center and anatomy adapted volumetric motion vector field interpolation delivers a 3D motion vector per voxel. Motion compensated filtered back projection incorporates this motion vector field in the image reconstruction process. This approach is applied in animal experiments on a flat panel C-arm system delivering improved image quality (lower artifact levels, improved tumor delineation) in 3D liver tumor imaging.

Artificial neural networks for control of a grid-connected rectifier/inverter under disturbance, dynamic and power converter switching conditions.

PubMed

Li, Shuhui; Fairbank, Michael; Johnson, Cameron; Wunsch, Donald C; Alonso, Eduardo; Proaño, Julio L

2014-04-01

Three-phase grid-connected converters are widely used in renewable and electric power system applications. Traditionally, grid-connected converters are controlled with standard decoupled d-q vector control mechanisms. However, recent studies indicate that such mechanisms show limitations in their applicability to dynamic systems. This paper investigates how to mitigate such restrictions using a neural network to control a grid-connected rectifier/inverter. The neural network implements a dynamic programming algorithm and is trained by using back-propagation through time. To enhance performance and stability under disturbance, additional strategies are adopted, including the use of integrals of error signals to the network inputs and the introduction of grid disturbance voltage to the outputs of a well-trained network. The performance of the neural-network controller is studied under typical vector control conditions and compared against conventional vector control methods, which demonstrates that the neural vector control strategy proposed in this paper is effective. Even in dynamic and power converter switching environments, the neural vector controller shows strong ability to trace rapidly changing reference commands, tolerate system disturbances, and satisfy control requirements for a faulted power system.

Design development of the Apollo command and service module thrust vector attitude control systems

NASA Technical Reports Server (NTRS)

Peters, W. H.

1978-01-01

Development of the Apollo thrust vector control digital autopilot (TVC DAP) was summarized. This is the control system that provided pitch and yaw attitude control during velocity change maneuvers using the main rocket engine on the Apollo service module. A list of ten primary functional requirements for this control system are presented, each being subordinate to a more general requirement appearing earlier on the list. Development process functions were then identified and the essential information flow paths were explored. This provided some visibility into the particular NASA/contractor interface, as well as relationships between the many individual activities.

An exploration of inter-organisational partnership assessment tools in the context of Australian Aboriginal-mainstream partnerships: a scoping review of the literature.

PubMed

Tsou, Christina; Haynes, Emma; Warner, Wayne D; Gray, Gordon; Thompson, Sandra C

2015-04-23

The need for better partnerships between Aboriginal organisations and mainstream agencies demands attention on process and relational elements of these partnerships, and improving partnership functioning through transformative or iterative evaluation procedures. This paper presents the findings of a literature review which examines the usefulness of existing partnership tools to the Australian Aboriginal-mainstream partnership (AMP) context. Three sets of best practice principles for successful AMP were selected based on authors' knowledge and experience. Items in each set of principles were separated into process and relational elements and used to guide the analysis of partnership assessment tools. The review and analysis of partnership assessment tools were conducted in three distinct but related parts. Part 1- identify and select reviews of partnership tools; part 2 - identify and select partnership self-assessment tool; part 3 - analysis of selected tools using AMP principles. The focus on relational and process elements in the partnership tools reviewed is consistent with the focus of Australian AMP principles by reconciliation advocates; however, historical context, lived experience, cultural context and approaches of Australian Aboriginal people represent key deficiencies in the tools reviewed. The overall assessment indicated that the New York Partnership Self-Assessment Tool and the VicHealth Partnership Analysis Tools reflect the greatest number of AMP principles followed by the Nuffield Partnership Assessment Tool. The New York PSAT has the strongest alignment with the relational elements while VicHealth and Nuffield tools showed greatest alignment with the process elements in the chosen AMP principles. Partnership tools offer opportunities for providing evidence based support to partnership development. The multiplicity of tools in existence and the reported uniqueness of each partnership, mean the development of a generic partnership analysis for AMP may not be a viable option for future effort.

Principals' reports of adults' alcohol use in Australian secondary schools.

PubMed

Ward, Bernadette M; Kippen, Rebecca; Buykx, Penny; Munro, Geoffrey; McBride, Nyanda; Wiggers, John

2016-02-29

Schools provide opportunities for parents and the wider community to connect and support the physical and emotional wellbeing of their children. Schools therefore have the potential to play a role in the socialisation of alcohol use through school policies and practices regarding consumption of alcohol by adults at school events in the presence of children. This survey was undertaken to a) compare the extent to which alcohol is used at secondary school events, when children are present, in the states of New South Wales (NSW) and Victoria (VIC), Australia; b) describe principals' level of agreement with these practices; c) their awareness of state policies on this issue; and d) the predictors of such events. A random sample of secondary schools, stratified to represent metropolitan and non-metropolitan schools were invited to participate. Bivariate and multivariate analysis were conducted with p values < 0.05 considered significant. A total of 241 (43%) schools consented to participate in the study. Fifteen percent of participating NSW schools and 57% of VIC schools held at least one event in which alcohol was consumed by adults in the presence of children in the year before the survey. Of the 100 reported events, 78% were Year 12 graduation dinners, and 18% were debutante balls. Compared to NSW principals, VIC principals were significantly more likely to agree with the use of alcohol at these events; significantly less likely to be aware of their state education department policy on this issue; have a policy at their own school or support policy that prohibits alcohol use at such events; and less likely to report having enough information to make decisions about this. There is a growing focus on adults' use of alcohol at school events when children are present. Schools can play an important role in educating and socialising children about alcohol via both the curriculum and policies regarding adults' alcohol use at school events. Findings from this study suggest education department and school-based policies that prohibit or restrict the use of alcohol, are significant predictors of adults' alcohol use at school events when children are present.

Monte Carlo sensitivity analysis of land surface parameters using the Variable Infiltration Capacity model

NASA Astrophysics Data System (ADS)

Demaria, Eleonora M.; Nijssen, Bart; Wagener, Thorsten

2007-06-01

Current land surface models use increasingly complex descriptions of the processes that they represent. Increase in complexity is accompanied by an increase in the number of model parameters, many of which cannot be measured directly at large spatial scales. A Monte Carlo framework was used to evaluate the sensitivity and identifiability of ten parameters controlling surface and subsurface runoff generation in the Variable Infiltration Capacity model (VIC). Using the Monte Carlo Analysis Toolbox (MCAT), parameter sensitivities were studied for four U.S. watersheds along a hydroclimatic gradient, based on a 20-year data set developed for the Model Parameter Estimation Experiment (MOPEX). Results showed that simulated streamflows are sensitive to three parameters when evaluated with different objective functions. Sensitivity of the infiltration parameter (b) and the drainage parameter (exp) were strongly related to the hydroclimatic gradient. The placement of vegetation roots played an important role in the sensitivity of model simulations to the thickness of the second soil layer (thick2). Overparameterization was found in the base flow formulation indicating that a simplified version could be implemented. Parameter sensitivity was more strongly dictated by climatic gradients than by changes in soil properties. Results showed how a complex model can be reduced to a more parsimonious form, leading to a more identifiable model with an increased chance of successful regionalization to ungauged basins. Although parameter sensitivities are strictly valid for VIC, this model is representative of a wider class of macroscale hydrological models. Consequently, the results and methodology will have applicability to other hydrological models.

M1A2 Adjunct Analysis (POSNOV Volume)

DTIC Science & Technology

1989-12-01

MD 20814-2797 Director 2 U.S. Army Materiel Systems Analysis Activity ATTN: AMXSY-CS, AMXSY-GA Aberden Proving Grounds , MD 21005-5071 U.S. Army...Leonard Wood, MO Commander U.S. Army Ordnance Center & School ATTN: ATSL-CD-CS Aberdeen Proving Ground , MD 21005 Commander 2 U.S. Army Soldier Support...NJ Commander U.S. Army Test and Evaluation Command ATrN: AMSTE-CM-R Aberdeen Proving Ground , MD 21005 Commander U.S. Army Tank Automotive Command

DDML Schema Validation

DTIC Science & Technology

2016-02-08

Data Display Markup Language HUD heads-up display IRIG Inter-Range Instrumentation Group RCC Range Commanders Council SVG Scalable Vector Graphics...T&E test and evaluation TMATS Telemetry Attributes Transfer Standard XML eXtensible Markup Language DDML Schema Validation, RCC 126-16, February...2016 viii This page intentionally left blank. DDML Schema Validation, RCC 126-16, February 2016 1 1. Introduction This Data Display Markup

Apollo Onboard Navigation Techniques

NASA Technical Reports Server (NTRS)

Interbartolo, Michael

2009-01-01

This viewgraph presentation reviews basic navigation concepts, describes coordinate systems and identifies attitude determination techniques including Primary Guidance, Navigation and Control System (PGNCS) IMU management and Command and Service Module Stabilization and Control System/Lunar Module (LM) Abort Guidance System (AGS) attitude management. The presentation also identifies state vector determination techniques, including PGNCS coasting flight navigation, PGNCS powered flight navigation and LM AGS navigation.

A direct application of the non-linear inverse transformation flight control system design on a STOVL aircraft

NASA Technical Reports Server (NTRS)

Chung, W. W.; Mcneill, W. E.; Stortz, M. W.

1993-01-01

The nonlinear inverse transformation flight control system design method is applied to the Lockheed Ft. Worth Company's E-7D short takeoff and vertical land (STOVL) supersonic fighter/attack aircraft design with a modified General Electric F110 engine which has augmented propulsive lift capability. The system is fully augmented to provide flight path control and velocity control, and rate command attitude hold for angular axes during the transition and hover operations. In cruise mode, the flight control system is configured to provide direct thrust command, rate command attitude hold for pitch and roll axes, and sideslip command with turn coordination. A control selector based on the nonlinear inverse transformation method is designed specifically to be compatible with the propulsion system's physical configuration which has a two dimensional convergent-divergent aft nozzle, a vectorable ventral nozzle, and a thrust augmented ejector. The nonlinear inverse transformation is used to determine the propulsive forces and nozzle deflections, which in combination with the aerodynamic forces and moments (including propulsive induced contributions), and gravitational force, are required to achieve the longitudinal and vertical acceleration commands. The longitudinal control axes are fully decoupled within the propulsion system's performance envelope. A piloted motion-base flight simulation was conducted on the Vertical Motion Simulator (VMS) at NASA Ames Research Center to examine the handling qualities of this design. Based on results of the simulation, refinements to the control system have been made and will also be covered in the report.

Historical and Future Projected Hydrologic Extremes over the Midwest and Great Lakes Region

NASA Astrophysics Data System (ADS)

Byun, K.; Hamlet, A. F.; Chiu, C. M.

2016-12-01

There is an increasing body of evidence from observed data that climate variability combined with regional climate change has had a significant impact on hydrologic cycles, including both seasonal patterns of runoff and altered hydrologic extremes (e.g. floods and extreme stormwater events). To better understand changing patterns of extreme high flows in Midwest and Great Lakes region, we analyzed long-term historical observations of peak streamflow at different gaging stations. We also conducted hydrologic model experiments using the Variable Infiltration Capacity (VIC) at 1/16 degree resolution in order to explore sensitivity of annual peak streamflow, both historically and under temperature and precipitation changes for several future periods. For future projections, the Hybrid Delta statistical downscaling approach applied to the Coupled Model Inter-comparison, Phase5 (CMIP5) Global Climate Model (GCM) scenarios was used to produce driving data for the VIC hydrologic model. Preliminary results for several test basins in the Midwest support the hypothesis that there are consistent and statistically significant changes in the mean annual flood starting before and after about 1975. Future projections using hydrologic model simulations support the hypothesis of higher peak flows due to warming and increasing precipitation projected for the 21st century. We will extend this preliminary analysis using observed data and simulations from 40 river basins in the Midwest to further test these hypotheses.

Utilisation of ART in single women and lesbian couples since the 2010 change in Victorian legislation.

PubMed

Fiske, Emily; Weston, Gareth

2014-10-01

Enactment of the Assisted Reproductive Treatment Act (Vic) 2008 in January 2010 allowed single persons and same sex couples in Victoria to access reproductive treatments. A retrospective cohort analysis of Monash IVF patients was conducted to identify trends in Assisted Reproductive Technology (ART) use amongst single women and lesbian couples after January 2010. A 102.8% increase in the utilisation of ART was observed amongst the single women group and a 248.8% increase in the lesbian couple population. © 2014 The Royal Australian and New Zealand College of Obstetricians and Gynaecologists.

Understanding The Individual Impacts Of Human Interventions And Climate Change On Hydrologic Variables In India

NASA Astrophysics Data System (ADS)

Sharma, T.; Chhabra, S., Jr.; Karmakar, S.; Ghosh, S.

2015-12-01

We have quantified the historical climate change and Land Use Land Cover (LULC) change impacts on the hydrologic variables of Indian subcontinent by using Variable Infiltration Capacity (VIC) mesoscale model at 0.5° spatial resolution and daily temporal resolution. The results indicate that the climate change in India has predominating effects on the basic water balance components such as water yield, evapotranspiration and soil moisture. This analysis is with the assumption of naturalised hydrologic cycle, i.e., the impacts of human interventions like construction of controlled (primarily dams, diversions and reservoirs) and water withdrawals structures are not taken into account. The assumption is unrealistic since there are numerous anthropogenic disturbances which result in large changes on vegetation composition and distribution patterns. These activities can directly or indirectly influence the dynamics of water cycle; subsequently affecting the hydrologic processes like plant transpiration, infiltration, evaporation, runoff and sublimation. Here, we have quantified the human interventions by using the reservoir and irrigation module of VIC model which incorporates the irrigation schemes, reservoir characteristics and water withdrawals. The impact of human interventions on hydrologic variables in many grids are found more predominant than climate change and might be detrimental to water resources at regional level. This spatial pattern of impacts will facilitate water manager and planners to design and station hydrologic structures for a sustainable water resources management.

An Estimate of HF/VHF Surface-Wave Communication Link Reaches in the West German Forest Environment

DTIC Science & Technology

1982-01-01

Naval Shipyard ATTN: AEAGD-MM(DCSLOG, Mun & Msl Div) ATTN: Commanding Officer 3 cy ATTN: DCSI-AEAGB-PDN David Taylor Naval Ship R & D Ctr U.S. Army... Shrier TRW Electronics & Defense Sector ATTN: R. Anspach Systems Research & Applications Corp ATTN: S. Greenstein Vector Research, Inc ATTN: S, Bonder R & D Associates 4 cy ATTN: G. Gordon 4 cy ATTN: E. Hoyt 60

21 CFR 520.2640 - Tylosin.

Code of Federal Regulations, 2012 CFR

2012-04-01

...)(vi)(c) of this chapter. (4) Honey bees—(i) Amount. Mix 200 milligrams tylosin in 20 grams... larvae). (iii) Limitations. The drug should be fed early in the spring or fall and consumed by the bees...

Thirty Meter Telescope (TMT) Narrow Field Infrared Adaptive Optics System (NFIRAOS) real-time controller preliminary architecture

NASA Astrophysics Data System (ADS)

Kerley, Dan; Smith, Malcolm; Dunn, Jennifer; Herriot, Glen; Véran, Jean-Pierre; Boyer, Corinne; Ellerbroek, Brent; Gilles, Luc; Wang, Lianqi

2016-08-01

The Narrow Field Infrared Adaptive Optics System (NFIRAOS) is the first light Adaptive Optics (AO) system for the Thirty Meter Telescope (TMT). A critical component of NFIRAOS is the Real-Time Controller (RTC) subsystem which provides real-time wavefront correction by processing wavefront information to compute Deformable Mirror (DM) and Tip/Tilt Stage (TTS) commands. The National Research Council of Canada - Herzberg (NRC-H), in conjunction with TMT, has developed a preliminary design for the NFIRAOS RTC. The preliminary architecture for the RTC is comprised of several Linux-based servers. These servers are assigned various roles including: the High-Order Processing (HOP) servers, the Wavefront Corrector Controller (WCC) server, the Telemetry Engineering Display (TED) server, the Persistent Telemetry Storage (PTS) server, and additional testing and spare servers. There are up to six HOP servers that accept high-order wavefront pixels, and perform parallelized pixel processing and wavefront reconstruction to produce wavefront corrector error vectors. The WCC server performs low-order mode processing, and synchronizes and aggregates the high-order wavefront corrector error vectors from the HOP servers to generate wavefront corrector commands. The Telemetry Engineering Display (TED) server is the RTC interface to TMT and other subsystems. The TED server receives all external commands and dispatches them to the rest of the RTC servers and is responsible for aggregating several offloading and telemetry values that are reported to other subsystems within NFIRAOS and TMT. The TED server also provides the engineering GUIs and real-time displays. The Persistent Telemetry Storage (PTS) server contains fault tolerant data storage that receives and stores telemetry data, including data for Point-Spread Function Reconstruction (PSFR).

Artificial Earth Satellites Designed and Fabricated by The Johns Hopkins University Applied Physics Laboratory. Revised

DTIC Science & Technology

1978-07-01

occurred. The attitude detection system included a three-axis fluxgate vector magnetometer and solar attitude detectors that produced both analog and digital ...heliogoniometer ( digital solar attitudeIsensing system) Three axis analog solar detection - Rubidium vapor magnetometer Three axis fluxgate magnetometer ...Telemetry: 35 channels modulating 150 MHz carrier on command Three axis solar attitude detector system Three axis fluxgate magnetometer system

Use of ILTV Control Laws for LaNCETS Flight Research

NASA Technical Reports Server (NTRS)

Moua, Cheng

2010-01-01

A report discusses the Lift and Nozzle Change Effects on Tail Shock (LaNCETS) test to investigate the effects of lift distribution and nozzle-area ratio changes on tail shock strength of an F-15 aircraft. Specific research objectives are to obtain inflight shock strength for multiple combinations of nozzle-area ratio and lift distribution; compare results with preflight prediction tools; and update predictive tools with flight results. The objectives from a stability and control perspective are to ensure adequate aircraft stability for the changes in lift distribution and plume shape, and ensure manageable transient from engaging and disengaging the ILTV research control laws. In order to change the lift distribution and plume shape of the F-15 aircraft, a decade-old Inner Loop Thrust Vectoring (ILTV) research control law was used. Flight envelope expansion was performed for the test configuration and flight conditions prior to the probing test points. The approach for achieving the research objectives was to utilize the unique capabilities of NASA's NF-15B-837 aircraft to allow the adjustment of the nozzle-area ratio and/or canard positions by engaging the ILTV research control laws. The ILTV control laws provide the ability to add trim command biases to canard positions, nozzle area ratios, and thrust vectoring through the use of datasets. Datasets consist of programmed test inputs (PTIs) that define trims to change the nozzle-area ratio and/or canard positions. The trims are applied as increments to the normally commanded positions. A LaNCETS non-linear, six-degrees-of-freedom simulation capable of realtime pilot-in-the-loop, hardware-in-the-loop, and non-real-time batch support was developed and validated. Prior to first flight, extensive simulation analyses were performed to show adequate stability margins with the changes in lift distribution and plume shape. Additionally, engagement/disengagement transient analysis was also performed to show manageable transients.

Embedding Mission Command in Army Culture

DTIC Science & Technology

2013-03-01

analysis of Army culture using ideas and concepts presented by Edgar H . Schein . 15. SUBJECT TERMS Army Leadership, Trust, Empowerment, Operational...The focal point of this study is an analysis of Army culture using ideas and concepts presented by Edgar H . Schein . Embedding...is an analysis of Army culture using ideas and concepts presented by Edgar H . Schein . Auftragstaktik and Mission Command Doctrine Mission command

An artificial neural network model for periodic trajectory generation

NASA Astrophysics Data System (ADS)

Shankar, S.; Gander, R. E.; Wood, H. C.

A neural network model based on biological systems was developed for potential robotic application. The model consists of three interconnected layers of artificial neurons or units: an input layer subdivided into state and plan units, an output layer, and a hidden layer between the two outer layers which serves to implement nonlinear mappings between the input and output activation vectors. Weighted connections are created between the three layers, and learning is effected by modifying these weights. Feedback connections between the output and the input state serve to make the network operate as a finite state machine. The activation vector of the plan units of the input layer emulates the supraspinal commands in biological central pattern generators in that different plan activation vectors correspond to different sequences or trajectories being recalled, even with different frequencies. Three trajectories were chosen for implementation, and learning was accomplished in 10,000 trials. The fault tolerant behavior, adaptiveness, and phase maintenance of the implemented network are discussed.

ARL Support and Analysis to the Army Public Health Command Kabul Air Quality Data Collection (Spring 2014)

DTIC Science & Technology

2016-05-01

ARL-TR-7692•MAY 2016 US Army Research Laboratory ARL Support and Analysis to the Army Public Health Command Kabul Air Quality Data Collection (Spring...return it to the originator. ARL-TR-7692•MAY 2016 US Army Research Laboratory ARL Support and Analysis to the Army Public Health Command Kabul Air Quality ...and Analysis to the Army Public Health Command Kabul Air Quality Data Collection (Spring 2014) Alan Wetmore and Thomas DeFelice ARL-TR-7692 Approved

Characterizing Cyclostationary Features of Digital Modulated Signals with Empirical Measurements using Spectral Correlation Function

DTIC Science & Technology

2011-06-01

USING SPECTRAL CORRELATION FUNCTION THESIS Mujun Song, Captain, ROKA AFIT/GCE/ENG/11-09 DEPARTMENT OF THE AIR FORCE AIR UNIVERSITY AIR...Management Air Force Institute of Technology Air University Air Education and Training Command In Partial Fulfillment of the Requirements for the...generator, Agilent E4438C, ESG Vector Signal Generator. Universal Software Radio Peripheral 2 (USRP2), which is a Software Defined Radio (SDR), is used

Software List.

ERIC Educational Resources Information Center

Computers in Chemical Education Newsletter, 1984

1984-01-01

Lists and briefly describes computer programs recently added to those currently available from Project SERAPHIM. Program name, subject, hardware, author, supplier, and current cost are provided in separate listings for Apple, Atari, Pet, VIC-20, TRS-80, and IBM-PC. (JN)

Efficient oxidation of alcohols to carbonyl compounds with molecular oxygen catalyzed by N-hydroxyphthalimide combined with a Co species

PubMed

Iwahama; Yoshino; Keitoku; Sakaguchi; Ishii

2000-10-06

Highly efficient catalytic oxidation of alcohols with molecular oxygen by N-hydroxyphthalimide (NHPI) combined with a Co species was developed. The oxidation of 2-octanol in the presence of catalytic amounts of NHPI and Co(OAc)2 under atmospheric dioxygen in AcOEt at 70 degrees C gave 2-octanone in 93% yield. The oxidation was significantly enhanced by adding a small amount of benzoic acid to proceed smoothly even at room temperature. Primary alcohols were oxidized by NHPI in the absence of any metal catalyst to form the corresponding carboxylic acids in good yields. In the oxidation of terminal vic-diols such as 1,2-butanediol, carbon-carbon bond cleavage was induced to give one carbon less carboxylic acids such as propionic acid, while internal vic-diols were selectively oxidized to 1,2-diketones.

Aviation Logistics in U.S. Pacific Command: A Cost-Based Analysis and Comparative Advantage to Commercial Shipment

DTIC Science & Technology

2012-12-01

IN U.S. PACIFIC COMMAND: A COST- BASED ANALYSIS AND COMPARATIVE ADVANTAGE TO COMMERCIAL SHIPMENT by Tod B. Diffey Matthew J. Beck December...PACIFIC COMMAND: A COST- BASED ANALYSIS AND COMPARATIVE ADVANTAGE TO COMMERCIAL SHIPMENT 5. FUNDING NUMBERS 6. AUTHOR(S) Tod B. Diffey and Matthew...this study will provide a cost based analysis and qualitative evaluation regarding the use of commercial agencies and/or United States Marine Corps

Attaining insight into interactions between hydrologic model parameters and geophysical attributes for national-scale model parameter estimation

NASA Astrophysics Data System (ADS)

Mizukami, N.; Clark, M. P.; Newman, A. J.; Wood, A.; Gutmann, E. D.

2017-12-01

Estimating spatially distributed model parameters is a grand challenge for large domain hydrologic modeling, especially in the context of hydrologic model applications such as streamflow forecasting. Multi-scale Parameter Regionalization (MPR) is a promising technique that accounts for the effects of fine-scale geophysical attributes (e.g., soil texture, land cover, topography, climate) on model parameters and nonlinear scaling effects on model parameters. MPR computes model parameters with transfer functions (TFs) that relate geophysical attributes to model parameters at the native input data resolution and then scales them using scaling functions to the spatial resolution of the model implementation. One of the biggest challenges in the use of MPR is identification of TFs for each model parameter: both functional forms and geophysical predictors. TFs used to estimate the parameters of hydrologic models typically rely on previous studies or were derived in an ad-hoc, heuristic manner, potentially not utilizing maximum information content contained in the geophysical attributes for optimal parameter identification. Thus, it is necessary to first uncover relationships among geophysical attributes, model parameters, and hydrologic processes (i.e., hydrologic signatures) to obtain insight into which and to what extent geophysical attributes are related to model parameters. We perform multivariate statistical analysis on a large-sample catchment data set including various geophysical attributes as well as constrained VIC model parameters at 671 unimpaired basins over the CONUS. We first calibrate VIC model at each catchment to obtain constrained parameter sets. Additionally, parameter sets sampled during the calibration process are used for sensitivity analysis using various hydrologic signatures as objectives to understand the relationships among geophysical attributes, parameters, and hydrologic processes.

Ares I Static Tests Design

NASA Technical Reports Server (NTRS)

Carson, William; Lindemuth, Kathleen; Mich, John; White, K. Preston; Parker, Peter A.

2009-01-01

Probabilistic engineering design enhances safety and reduces costs by incorporating risk assessment directly into the design process. In this paper, we assess the format of the quantitative metrics for the vehicle which will replace the Space Shuttle, the Ares I rocket. Specifically, we address the metrics for in-flight measurement error in the vector position of the motor nozzle, dictated by limits on guidance, navigation, and control systems. Analyses include the propagation of error from measured to derived parameters, the time-series of dwell points for the duty cycle during static tests, and commanded versus achieved yaw angle during tests. Based on these analyses, we recommend a probabilistic template for specifying the maximum error in angular displacement and radial offset for the nozzle-position vector. Criteria for evaluating individual tests and risky decisions also are developed.

Air Mobility Command Global Reach to Africa: Sustained Rapid Global Mobility to United States Africa Command

DTIC Science & Technology

2009-06-12

the entire Global Reach Laydown (GRL) strategy. Finally, analysis within this paper shows a correlation between political climate , basing, ground...17 Analysis of Literature...study researched Air Mobility Command (AMC) delivery of DoD resources to and through USAFRICOM. Specifically, the research and analysis within

Aviation Logistics in U.S. Pacific Command: A Cost-Based Analysis and Comparative Advantage to Commercial Shipment

DTIC Science & Technology

2012-11-20

pbofbp= Aviation Logistics in U.S. Pacific Command: A Cost- Based Analysis and Comparative Advantage to Commercial Shipment 20 November 2012...AND SUBTITLE Aviation Logistics in U.S. Pacific Command: A Cost- Based Analysis and Comparative Advantage to Commercial Shipment 5a. CONTRACT NUMBER...asset throughput in the customs departments of our allied nations. In considering and analyzing these dynamics, this study provides a cost- based

Apollo guidance, navigation and control: Guidance system operations plan for manned CM earth orbital and lunar missions using Program COLOSSUS 3. Section 3: Digital autopilots (revision 14)

NASA Technical Reports Server (NTRS)

1972-01-01

Digital autopilots for the manned command module earth orbital and lunar missions using program COLOSSUS 3 are discussed. Subjects presented are: (1) reaction control system digital autopilot, (2) thrust vector control autopilot, (3) entry autopilot and mission control programs, (4) takeover of Saturn steering, and (5) coasting flight attitude maneuver routine.

Robotic application of a dynamic resultant force vector using real-time load-control: simulation of an ideal follower load on Cadaveric L4-L5 segments.

PubMed

Bennett, Charles R; Kelly, Brian P

2013-08-09

Standard in-vitro spine testing methods have focused on application of isolated and/or constant load components while the in-vivo spine is subject to multiple components that can be resolved into resultant dynamic load vectors. To advance towards more in-vivo like simulations the objective of the current study was to develop a methodology to apply robotically-controlled, non-zero, real-time dynamic resultant forces during flexion-extension on human lumbar motion segment units (MSU) with initial application towards simulation of an ideal follower load (FL) force vector. A proportional-integral-derivative (PID) controller with custom algorithms coordinated the motion of a Cartesian serial manipulator comprised of six axes each capable of position- or load-control. Six lumbar MSUs (L4-L5) were tested with continuously increasing sagittal plane bending to 8 Nm while force components were dynamically programmed to deliver a resultant 400 N FL that remained normal to the moving midline of the intervertebral disc. Mean absolute load-control tracking errors between commanded and experimental loads were computed. Global spinal ranges of motion and sagittal plane inter-body translations were compared to previously published values for non-robotic applications. Mean TEs for zero-commanded force and moment axes were 0.7 ± 0.4N and 0.03 ± 0.02 Nm, respectively. For non-zero force axes mean TEs were 0.8 ± 0.8 N, 1.3 ± 1.6 Nm, and 1.3 ± 1.6N for Fx, Fz, and the resolved ideal follower load vector FL(R), respectively. Mean extension and flexion ranges of motion were 2.6° ± 1.2° and 5.0° ± 1.7°, respectively. Relative vertebral body translations and rotations were very comparable to data collected with non-robotic systems in the literature. The robotically coordinated Cartesian load controlled testing system demonstrated robust real-time load-control that permitted application of a real-time dynamic non-zero load vector during flexion-extension. For single MSU investigations the methodology has potential to overcome conventional follower load limitations, most notably via application outside the sagittal plane. This methodology holds promise for future work aimed at reducing the gap between current in-vitro testing and in-vivo circumstances. Copyright © 2013 Elsevier Ltd. All rights reserved.

21 CFR 520.2640 - Tylosin.

Code of Federal Regulations, 2014 CFR

2014-04-01

... phosphate medicated feed as in § 558.625(f)(1)(vi)(c) of this chapter. (4) Honey bees—(i) Amount. Mix 200... spring or fall and consumed by the bees before the main honey flow begins, to avoid contamination of...

21 CFR 520.2640 - Tylosin.

Code of Federal Regulations, 2013 CFR

2013-04-01

... phosphate medicated feed as in § 558.625(f)(1)(vi)(c) of this chapter. (4) Honey bees—(i) Amount. Mix 200... spring or fall and consumed by the bees before the main honey flow begins, to avoid contamination of...

COX2 Inhibition Reduces Aortic Valve Calcification In Vivo

PubMed Central

Wirrig, Elaine E.; Gomez, M. Victoria; Hinton, Robert B.; Yutzey, Katherine E.

2016-01-01

Objective Calcific aortic valve disease (CAVD) is a significant cause of morbidity and mortality, which affects approximately 1% of the US population and is characterized by calcific nodule formation and stenosis of the valve. Klotho-deficient mice were used to study the molecular mechanisms of CAVD as they develop robust aortic valve (AoV) calcification. Through microarray analysis of AoV tissues from klotho-deficient and wild type mice, increased expression of the gene encoding cyclooxygenase 2/COX2 (Ptgs2) was found. COX2 activity contributes to bone differentiation and homeostasis, thus the contribution of COX2 activity to AoV calcification was assessed. Approach and Results In klotho-deficient mice, COX2 expression is increased throughout regions of valve calcification and is induced in the valvular interstitial cells (VICs) prior to calcification formation. Similarly, COX2 expression is increased in human diseased AoVs. Treatment of cultured porcine aortic VICs with osteogenic media induces bone marker gene expression and calcification in vitro, which is blocked by inhibition of COX2 activity. In vivo, genetic loss of function of COX2 cyclooxygenase activity partially rescues AoV calcification in klotho-deficient mice. Moreover, pharmacologic inhibition of COX2 activity in klotho-deficient mice via celecoxib-containing diet reduces AoV calcification and blocks osteogenic gene expression. Conclusions COX2 expression is upregulated in CAVD and its activity contributes to osteogenic gene induction and valve calcification in vitro and in vivo. PMID:25722432

Inflammation Drives Retraction, Stiffening, and Nodule Formation via Cytoskeletal Machinery in a Three-Dimensional Culture Model of Aortic Stenosis.

PubMed

Lim, Jina; Ehsanipour, Arshia; Hsu, Jeffrey J; Lu, Jinxiu; Pedego, Taylor; Wu, Alexander; Walthers, Chris M; Demer, Linda L; Seidlits, Stephanie K; Tintut, Yin

2016-09-01

In calcific aortic valve disease, the valve cusps undergo retraction, stiffening, and nodular calcification. The inflammatory cytokine, tumor necrosis factor (TNF)-α, contributes to valve disease progression; however, the mechanisms of its actions on cusp retraction and stiffening are unclear. We investigated effects of TNF-α on murine aortic valvular interstitial cells (VICs) within three-dimensional, free-floating, compliant, collagen hydrogels, simulating their natural substrate and biomechanics. TNF-α increased retraction (percentage of diameter), stiffness, and formation of macroscopic, nodular structures with calcification in the VIC-laden hydrogels. The effects of TNF-α were attenuated by blebbistatin inhibition of myosin II-mediated cytoskeletal contraction. Inhibition of actin polymerization with cytochalasin-D, but not inhibition of Rho kinase with Y27632, blocked TNF-α-induced retraction in three-dimensional VIC hydrogels, suggesting that actin stress fibers mediate TNF-α-induced effects. In the hydrogels, inhibitors of NF-κB blocked TNF-α-induced retraction, whereas simultaneous inhibition of c-Jun N-terminal kinase was required to block TNF-α-induced stiffness. TNF-α also significantly increased collagen deposition, as visualized by Masson's trichrome staining, and up-regulated mRNA expression of discoidin domain receptor tyrosine kinase 2, fibronectin, and α-smooth muscle actin. In human aortic valves, calcified cusps were stiffer and had more collagen deposition than noncalcified cusps. These findings suggest that inflammation, through stimulation of cytoskeletal contractile activity, may be responsible for valvular cusp retraction, stiffening, and formation of calcified nodules. Copyright © 2016 American Society for Investigative Pathology. Published by Elsevier Inc. All rights reserved.

An integrated approach for estimation of methane emissions from wetlands and lakes in high latitude regions

NASA Astrophysics Data System (ADS)

Chiu, C.; Bowling, L. C.; Podest, E.; Bohn, T. J.; Lettenmaier, D. P.; Schroeder, R.; McDonald, K. C.

2009-04-01

In recent years, there has been increasing evidence of significant alteration in the extent of lakes and wetlands in high latitude regions due in part to thawing permafrost, as well as other changes governing surface and subsurface hydrology. Methane is a 23 times more efficient greenhouse gas than carbon dioxide; changes in surface water extent, and the associated subsurface anaerobic conditions, are important controls on methane emissions in high latitude regions. Methane emissions from wetlands vary substantially in both time and space, and are influenced by plant growth, soil organic matter decomposition, methanogenesis, and methane oxidation controlled by soil temperature, water table level and net primary productivity (NPP). The understanding of spatial and temporal heterogeneity of surface saturation, thermal regime and carbon substrate in northern Eurasian wetlands from point measurements are limited. In order to better estimate the magnitude and variability of methane emissions from northern lakes and wetlands, we present an integrated assessment approach based on remote sensing image classification, land surface modeling and process-based ecosystem modeling. Wetlands classifications based on L-band JERS-1 SAR (100m) and ALOS PALSAR (~30m) are used together with topographic information to parameterize a lake and wetland algorithm in the Variable Infiltration Capacity (VIC) land surface model at 25 km resolution. The enhanced VIC algorithm allows subsurface moisture exchange between surface water and wetlands and includes a sub-grid parameterization of water table position within the wetland area using a generalized topographic index. Average methane emissions are simulated by using the Walter and Heimann methane emission model based on temporally and spatially varying soil temperature, net primary productivity and water table generated from the modified VIC model. Our five preliminary study areas include the Z. Dvina, Upper Volga, Yeloguy, Syum, and Chaya river basins. The temporally-variable inundation extent simulated by the VIC model is compared to 25 km resolution inundation products developed from combined QuikSCAT, AMSR-E and MODIS data sets covering the time period from 2002 onward. The seasonal variation in methane emissions associated with sub-grid variability in water table extent is explored between 1948 and 2006. This work was carried out at Purdue University, at the University of Washington, and at the Jet Propulsion Laboratory, California Institute of Technology, under contract with the NASA.

Potential impacts of agricultural drought on crop yield variability under a changing climate in Texas

NASA Astrophysics Data System (ADS)

Lee, K.; Leng, G.; Huang, M.; Sheffield, J.; Zhao, G.; Gao, H.

2017-12-01

Texas has the largest farm area in the U.S, and its revenue from crop production ranks third overall. With the changing climate, hydrological extremes such as droughts are becoming more frequent and intensified, causing significant yield reduction in rainfed agricultural systems. The objective of this study is to investigate the potential impacts of agricultural drought on crop yields (corn, sorghum, and wheat) under a changing climate in Texas. The Variable Infiltration Capacity (VIC) model, which is calibrated and validated over 10 major Texas river basins during the historical period, is employed in this study.The model is forced by a set of statistically downscaled climate projections from Coupled Model Intercomparison Project Phase 5 (CMIP5) model ensembles at a spatial resolution of 1/8°. The CMIP5 projections contain four Representative Concentration Pathways (RCP) that represent different greenhouse gas concentration (4.5 and 8.5 w/m2 are selected in this study). To carry out the analysis, VIC simulations from 1950 to 2099 are first analyzed to investigate how the frequency and severity of agricultural droughts will be altered in Texas (under a changing climate). Second, future crop yields are projected using a statistical crop model. Third, the effects of agricultural drought on crop yields are quantitatively analyzed. The results are expected to contribute to future water resources planning, with a goal of mitigating the negative impacts of future droughts on agricultural production in Texas.

Coupling Meteorological, Land Surface and Water Temperature Models in the Mississippi River Basin

NASA Astrophysics Data System (ADS)

Tang, C.; Cooter, E. J.

2017-12-01

Water temperature is a significant factor influencing of the stream ecosystem and water management especially under climate change. In this study, we demonstrate a physically based semi-Lagrangian water temperature model (RBM) coupled with the Variable Infiltration Capacity (VIC) hydrology model and Weather Research & Forecasting Model (WRF) in the Mississippi River Basin (MRB). The results of this coupling compare favorably with observed water temperature data at river gages throughout the MRB. Further sensitivity analysis shows that mean water temperatures increase by 1.3°C, 1.5°C, and 1.8°C in northern, central and southern MRB zones, respectively, under a hypothetical uniform air temperature increase of 3°C. If air temperatures increase uniformly by 6°C in this scenario, then water temperatures are projected to increase by 3.3°C, 3.5°C and 4.0°C. Lastly, downscaled air temperatures from a global climate model are used to drive the coupled VIC and RBM model from 2020 to 2099. Average stream temperatures from 2020 to 2099 increase by 1°C to 8°C above 1950 to 2010 average water temperatures, with non-uniform increases along the river. In some portions of the MRB, stream temperatures could increase above survival thresholds for several native fish species, which are critical components of the stream ecosystem. The increased water temperature accelerates harmful algal blooming which results in a larger dead zone in the Gulf of Mexico.

A versatile approach to vacuum injection casting for materials research and development.

PubMed

Xu, Donghua; Xu, Yifan

2017-03-01

Vacuum injection casting (VIC) is important for research and development (R&D) of materials that are prone to oxidation at high temperatures, particularly metals and metallic alloys (e.g., metallic glasses and high entropy alloys). VIC in R&D laboratories often involves initial melting/alloying in a prior step, transporting the sample to a dedicated vacuum chamber, re-melting the sample in a quartz tube, and finally injecting the melt with an inert gas to a dedicated mold. Here we present a new approach to laboratory VIC that requires no sample transfer (for a variety of materials), no dedicated vacuum chamber/space nor dedicated mold, and hence provides more versatility and higher efficiency and yet lowers the capital equipment cost. Our approach takes advantage of the exceptional portability, thermal and chemical stability, and thermoplastic processability of quartz glass and uses quartz tubes for all the melting, re-melting, injection casting, and molding. In addition, our approach includes oxygen gettering to remove residual oxygen for all the steps and allows for slow or fast cooling (e.g., water quenching) upon injection. This paper focuses on the design, the procedures, and the versatile features of this new approach while also demonstrating the practical implementation of this approach and computational modeling of the heat transfer and the cooling rates for two exemplary cases. The new approach is expected to bring notable expedition to sample fabrication and materials discovery, as well as wider adoption of vacuum injection casting in materials science and condensed matter physics research laboratories.

A versatile approach to vacuum injection casting for materials research and development

NASA Astrophysics Data System (ADS)

Xu, Donghua; Xu, Yifan

2017-03-01

Vacuum injection casting (VIC) is important for research and development (R&D) of materials that are prone to oxidation at high temperatures, particularly metals and metallic alloys (e.g., metallic glasses and high entropy alloys). VIC in R&D laboratories often involves initial melting/alloying in a prior step, transporting the sample to a dedicated vacuum chamber, re-melting the sample in a quartz tube, and finally injecting the melt with an inert gas to a dedicated mold. Here we present a new approach to laboratory VIC that requires no sample transfer (for a variety of materials), no dedicated vacuum chamber/space nor dedicated mold, and hence provides more versatility and higher efficiency and yet lowers the capital equipment cost. Our approach takes advantage of the exceptional portability, thermal and chemical stability, and thermoplastic processability of quartz glass and uses quartz tubes for all the melting, re-melting, injection casting, and molding. In addition, our approach includes oxygen gettering to remove residual oxygen for all the steps and allows for slow or fast cooling (e.g., water quenching) upon injection. This paper focuses on the design, the procedures, and the versatile features of this new approach while also demonstrating the practical implementation of this approach and computational modeling of the heat transfer and the cooling rates for two exemplary cases. The new approach is expected to bring notable expedition to sample fabrication and materials discovery, as well as wider adoption of vacuum injection casting in materials science and condensed matter physics research laboratories.

Elevated Serotonin Interacts with Angiotensin-II to Result in Altered Valve Interstitial Cell Contractility and Remodeling.

PubMed

Perez, Jessica; Diaz, Nancy; Tandon, Ishita; Plate, Rachel; Martindale, Christopher; Balachandran, Kartik

2018-06-01

While the valvulopathic effects of serotonin (5HT) and angiotensin-II (Ang-II) individually are known, it was not clear how 5HT and Ang-II might interact, specifically in the context of the mechanobiological responses due to altered valve mechanics potentiated by these molecules. In this context, the hypothesis of this study was that increased serotonin levels would result in accelerated progression toward disease in the presence of angiotensin-II-induced hypertension. C57/BL6 J mice were divided into four groups and subcutaneously implanted with osmotic pumps containing: PBS (control), 5HT (2.5 ng/kg/min), Ang-II (400 ng/kg/min), and 5HT + Ang-II (combination). Blood pressure was monitored using the tail cuff method. Echocardiography was performed on the mice before surgery and every week thereafter to assess ejection fraction. After three weeks, the mice were sacrificed and their hearts excised, embedded and sectioned for analysis of the aortic valves via histology and immunohistochemistry. In separate experiments, porcine valve interstitial cells (VICs) were directly stimulated with 5HT (10 -7  M), Ang-II (100 nM) or both and assayed for cellular contractility, cytoskeletal organization and collagen remodeling. After three weeks, average systolic blood pressure was significantly increased in the 5HT, Ang-II and combination groups compared to control. Echocardiographic analysis demonstrated significantly reduced ejection fraction in Ang-II and the combination groups. H&E staining demonstrated thicker leaflets in the combination groups, suggesting a more aggressive remodeling process. Picrosirius red staining and image analysis suggested that the Ang-II and combination groups had the largest proportion of thicker collagen fibers. VIC orientation, cellular contractility and collagen gene expression was highest for the 5HT + Ang-II combination treatment compared to all other groups. Overall, our results suggest that 5HT and Ang-II interact to result in significantly detrimental alteration of function and remodeling in the valve.

Terminal Information Processing System (TIPS) Consolidated CAB Display (CCD) Comparative Analysis.

DTIC Science & Technology

1982-04-01

Barometric pressure 3. Center field wind speed, direction and gusts 4. Runway visual range 5. Low-level wind shear 6. Vortex advisory 7. Runway equipment...PASSWORD Command (standard user) u. PAUSE Command (standard user) v. PMSG Command (standard user) w. PPD Command (standard user) x. PURGE Command (standard

Integration of Satellite, Global Reanalysis Data and Macroscale Hydrological Model for Drought Assessment in Sub-Tropical Region of India

NASA Astrophysics Data System (ADS)

Pandey, V.; Srivastava, P. K.

2018-04-01

Change in soil moisture regime is highly relevant for agricultural drought, which can be best analyzed in terms of Soil Moisture Deficit Index (SMDI). A macroscale hydrological model Variable Infiltration Capacity (VIC) was used to simulate the hydro-climatological fluxes including evapotranspiration, runoff, and soil moisture storage to reconstruct the severity and duration of agricultural drought over semi-arid region of India. The simulations in VIC were performed at 0.25° spatial resolution by using a set of meteorological forcing data, soil parameters and Land Use Land Cover (LULC) and vegetation parameters. For calibration and validation, soil parameters obtained from National Bureau of Soil Survey and Land Use Planning (NBSSLUP) and ESA's Climate Change Initiative soil moisture (CCI-SM) data respectively. The analysis of results demonstrates that most of the study regions (> 80 %) especially for central northern part are affected by drought condition. The year 2001, 2002, 2007, 2008 and 2009 was highly affected by agricultural drought. Due to high average and maximum temperature, we observed higher soil evaporation that reduces the surface soil moisture significantly as well as the high topographic variations; coarse soil texture and moderate to high wind speed enhanced the drying upper soil moisture layer that incorporate higher negative SMDI over the study area. These findings can also facilitate the archetype in terms of daily time step data, lengths of the simulation period, various hydro-climatological outputs and use of reasonable hydrological model.

Missing in Action: Where Are the Air Force’s Geographic Combatant Commanders

DTIC Science & Technology

2011-06-01

worship at the altar of technology. The airplane from its inception has been an expression of the miracle of technology.”12 The Air Force’s love ...Nichols also gave the 1 Wiley L . Barnes, "A New Vector for Air Force Development of Joint Leaders...budgeting decisions and leadership assignments. Budgeting decisions such as priority being given to the F-22, F-35, and space programs point to a love of

Word Frequency Analysis. MOS: 16P. Skill Levels 1 & 2.

DTIC Science & Technology

1981-05-01

8217 ALSC1 ALP ESECATE I API’LYI A-129 I AjI ~ AS-L-%/VIC I ATTAIN I1As~L2r v L% WORO FAeQUIEN#rM r Tf~16O RIATE 80142 131? PACE 3 I AV-@ ____ I...ENOJ 21..i~u. 191.4PME 21MAV UOi.~lO51’.iNEe;W~1CA2SP1tF4i H4PiI**IAPI C, 4DS-I*~4A5-II..... ROJOS 1.....9 PM4 21 MY §So.OOH 512 CH.PN~𔄁..IAR

Modeling control of eye orientation in three dimensions. I. Role of muscle pulleys in determining saccadic trajectory.

PubMed

Raphan, T

1998-05-01

This study evaluates the effects of muscle axis shifts on the performance of a vector velocity-position integrator in the CNS. Earlier models of the oculomotor plant assumed that the muscle axes remained fixed relative to the head as the eye rotated into secondary and tertiary eye positions. Under this assumption, the vector integrator model generates torsional transients as the eye moves from secondary to tertiary positions of fixation. The torsional transient represents an eye movement response to a spatial mismatch between the torque axes that remain fixed in the head and the displacement plane that changes by half the angle of the change in eye orientation. When muscle axis shifts were incorporated into the model, the torque axes were closer to the displacement plane at each eye orientation throughout the trajectory, and torsional transients were reduced dramatically. Their size and dynamics were close to reported data. It was also shown that when the muscle torque axes were rotated by 50% of the eye rotation, there was no torsional transient and Listing's law was perfectly obeyed. When muscle torque axes rotated >50%, torsional transients reversed direction compared with what occurred for muscle axis shifts of <50%. The model indicates that Listing's law is implemented by the oculomotor plant subject to a two-dimensional command signal that is confined to the pitch-yaw plane, having zero torsion. Saccades that bring the eye to orientations outside Listing's plane could easily be corrected by a roll pulse that resets the roll state of the velocity-position integrator to zero. This would be a simple implementation of the corrective controller suggested by Van Opstal and colleagues. The model further indicates that muscle axis shifts together with the torque orientation relationship for tissue surrounding the eye and Newton's laws of motion form a sufficient plant model to explain saccadic trajectories and periods of fixation when driven by a vector command confined to the pitch-yaw plane. This implies that the velocity-position integrator is probably realized as a subtractive feedback vector integrator and not as a quaternion-based integrator that implements kinematic transformations to orient the eye.

Computer Program Development Specification for Tactical Interface System.

DTIC Science & Technology

1981-07-31

CNTL CNTL TO ONE VT~i.AE CR1 & TWELVE VT100 LCARD READER VIDEO TERMINALS, SIX LA12O) HARD- COPY TERMINALS, & VECTOR GRAPHICS RPO % TERMINAL 17%M DISK...this data into the TIS para - .. meter tables in the TISGBL common area. ICEHANDL will send test interface ICE to PSS in one of two modes: perio- dically...STOPCauss te TI sotwar toexit ,9.*9~ .r .~ * ~%.’h .9~ .. a .~ .. a. 1 , , p * % .’.-:. .m 7 P : SDSS-MMP-BI ." 31 July 1981 TCL commands authorized

Longitudinal handling qualities during approach and landing of a powered lift STOL aircraft

NASA Technical Reports Server (NTRS)

Franklin, J. A.; Innis, R. C.

1972-01-01

Longitudinal handling qualities evaluations were conducted on the Ames Research Center Flight Simulator for Advanced Aircraft (FSAA) for the approach and landing tasks of a powered lift STOL research aircraft. The test vehicle was a C-8A aircraft modified with a new wing incorporating internal blowing over an augmentor flap. The investigation included: (1) use of various flight path and airspeed control techniques for the basic vehicle; (2) assessment of stability and command augmentation schemes for pitch attitude and airspeed control; (3) determination of the influence of longitudinal and vertical force coupling for the power control; (4) determination of the influence of pitch axis coupling with the thrust vector control; and (5) evaluations of the contribution of stability and command augmentation to recovery from a single engine failure. Results are presented in the form of pilot ratings and commentary substantiated by landing approach time histories.

Testing of the on-board attitude determination and control algorithms for SAMPEX

NASA Technical Reports Server (NTRS)

Mccullough, Jon D.; Flatley, Thomas W.; Henretty, Debra A.; Markley, F. Landis; San, Josephine K.

1993-01-01

Algorithms for on-board attitude determination and control of the Solar, Anomalous, and Magnetospheric Particle Explorer (SAMPEX) have been expanded to include a constant gain Kalman filter for the spacecraft angular momentum, pulse width modulation for the reaction wheel command, an algorithm to avoid pointing the Heavy Ion Large Telescope (HILT) instrument boresight along the spacecraft velocity vector, and the addition of digital sun sensor (DSS) failure detection logic. These improved algorithms were tested in a closed-loop environment for three orbit geometries, one with the sun perpendicular to the orbit plane, and two with the sun near the orbit plane - at Autumnal Equinox and at Winter Solstice. The closed-loop simulator was enhanced and used as a truth model for the control systems' performance evaluation and sensor/actuator contingency analysis. The simulations were performed on a VAX 8830 using a prototype version of the on-board software.

The introduction of buprenorphine-naloxone film in opioid substitution therapy in Australia: Uptake and issues arising from changing buprenorphine formulations.

PubMed

Larance, Briony; Dietze, Paul; Ali, Robert; Lintzeris, Nicholas; White, Nancy; Jenkinson, Rebecca; Degenhardt, Louisa

2015-11-01

Buprenorphine-naloxone (BNX) film for opioid dependence treatment was introduced in Australia in 2011. A key difference in State policy approaches saw transfer from BNX tablets to BNX film mandated in South Australia (SA) with New South Wales (NSW) and Victoria (VIC) having less stringent policies. This study examined (i) how initiations and transfers were implemented, (ii) the profile and predictors of adverse effects as self-reported by BNX film clients, and (iii) dosing issues. Survey of 334 buprenorphine (BPN), BNX tablet and BNX film clients and semi-structured interviews with 39 key experts (KEs) in 2012. Comparisons are made between clients interviewed in SA versus NSW and VIC combined. Among the 180 current BNX film clients, 23% started treatment on BNX film, 18% requested a transfer to BNX film and 59% (n = 106) reported their clinic/prescriber recommended transfer to BNX film. Among clients who were offered but refused a transfer to BNX film (n = 66), the most common reason was 'I am happy with my current treatment and do not see a reason to change' (53%). Some opioid substitution therapy clients and KE viewed transfers as 'forced' (i.e. no choice of buprenorphine formulation). Multivariable regression showed residing in SA (vs. NSW/VIC) and a shorter length of current treatment episode were associated with more BNX film-attributed adverse effects but clinic/prescriber-recommended transfer was not. The introduction of BNX film in Australia varied across States. A perception of restricted choice in medication may have undermined initial acceptance in SA. © 2015 Australasian Professional Society on Alcohol and other Drugs.

Water Temperature changes in the Mississippi River Basin

EPA Science Inventory

In this study, we demonstrate the transfer of a physically based semi-Lagrangian water temperature model (RBM) to EPA, its linkage with the Variable Infiltration Capacity (VIC) hydrology model, and its calibration to and demonstration for the Mississippi River Basin (MRB). The r...

Modeling water scarcity over south Asia: Incorporating crop growth and irrigation models into the Variable Infiltration Capacity (VIC) model

NASA Astrophysics Data System (ADS)

Troy, Tara J.; Ines, Amor V. M.; Lall, Upmanu; Robertson, Andrew W.

2013-04-01

Large-scale hydrologic models, such as the Variable Infiltration Capacity (VIC) model, are used for a variety of studies, from drought monitoring to projecting the potential impact of climate change on the hydrologic cycle decades in advance. The majority of these models simulates the natural hydrological cycle and neglects the effects of human activities such as irrigation, which can result in streamflow withdrawals and increased evapotranspiration. In some parts of the world, these activities do not significantly affect the hydrologic cycle, but this is not the case in south Asia where irrigated agriculture has a large water footprint. To address this gap, we incorporate a crop growth model and irrigation model into the VIC model in order to simulate the impacts of irrigated and rainfed agriculture on the hydrologic cycle over south Asia (Indus, Ganges, and Brahmaputra basin and peninsular India). The crop growth model responds to climate signals, including temperature and water stress, to simulate the growth of maize, wheat, rice, and millet. For the primarily rainfed maize crop, the crop growth model shows good correlation with observed All-India yields (0.7) with lower correlations for the irrigated wheat and rice crops (0.4). The difference in correlation is because irrigation provides a buffer against climate conditions, so that rainfed crop growth is more tied to climate than irrigated crop growth. The irrigation water demands induce hydrologic water stress in significant parts of the region, particularly in the Indus, with the streamflow unable to meet the irrigation demands. Although rainfall can vary significantly in south Asia, we find that water scarcity is largely chronic due to the irrigation demands rather than being intermittent due to climate variability.

Evaluating the influence of antecedent soil moisture on variability of the North American Monsoon precipitation in the coupled MM5/VIC modeling system

DOE Office of Scientific and Technical Information (OSTI.GOV)

Zhu, Chunmei; Leung, Lai R.; Gochis, David

2009-11-29

The influence of antecedent soil moisture on North American monsoon system (NAMS) precipitation variability was explored using the MM5 mesoscale model coupled with the Variable Infiltration Capacity (VIC) land surface model. Sensitivity experiments were performed with extreme wet and dry initial soil moisture conditions for both the 1984 wet monsoon year and the 1989 dry year. The MM5-VIC model reproduced the key features of NAMS in 1984 and 1989 especially over northwestern Mexico. Our modeling results indicate that the land surface has memory of the initial soil wetness prescribed at the onset of the monsoon that persists over most ofmore » the region well into the monsoon season (e.g. until August). However, in contrast to the classical thermal contrast concept, where wetter soils lead to cooler surface temperatures, less land-sea thermal contrast, weaker monsoon circulations and less precipitation, the coupled model consistently demonstrated a positive soil moisture – precipitation feedback. Specifically, anomalously wet premonsoon soil moisture always lead to enhanced monsoon precipitation, and the reverse was also true. The surface temperature changes induced by differences in surface energy flux partitioning associated with pre-monsoon soil moisture anomalies changed the surface pressure and consequently the flow field in the coupled model, which in turn changed moisture convergence and, accordingly, precipitation patterns. Both the largescale circulation change and local land-atmospheric interactions in response to premonsoon soil moisture anomalies play important roles in the coupled model’s positive soil moisture monsoon precipitation feedback. However, the former may be sensitive to the strength and location of the thermal anomalies, thus leaving open the possibility of both positive and negative soil moisture precipitation feedbacks.« less

chemalot and chemalot_knime: Command line programs as workflow tools for drug discovery.

PubMed

Lee, Man-Ling; Aliagas, Ignacio; Feng, Jianwen A; Gabriel, Thomas; O'Donnell, T J; Sellers, Benjamin D; Wiswedel, Bernd; Gobbi, Alberto

2017-06-12

Analyzing files containing chemical information is at the core of cheminformatics. Each analysis may require a unique workflow. This paper describes the chemalot and chemalot_knime open source packages. Chemalot is a set of command line programs with a wide range of functionalities for cheminformatics. The chemalot_knime package allows command line programs that read and write SD files from stdin and to stdout to be wrapped into KNIME nodes. The combination of chemalot and chemalot_knime not only facilitates the compilation and maintenance of sequences of command line programs but also allows KNIME workflows to take advantage of the compute power of a LINUX cluster. Use of the command line programs is demonstrated in three different workflow examples: (1) A workflow to create a data file with project-relevant data for structure-activity or property analysis and other type of investigations, (2) The creation of a quantitative structure-property-relationship model using the command line programs via KNIME nodes, and (3) The analysis of strain energy in small molecule ligand conformations from the Protein Data Bank database. The chemalot and chemalot_knime packages provide lightweight and powerful tools for many tasks in cheminformatics. They are easily integrated with other open source and commercial command line tools and can be combined to build new and even more powerful tools. The chemalot_knime package facilitates the generation and maintenance of user-defined command line workflows, taking advantage of the graphical design capabilities in KNIME. Graphical abstract Example KNIME workflow with chemalot nodes and the corresponding command line pipe.

Model Estimates of Pan-Arctic Lake and Wetland Methane Emissions

NASA Astrophysics Data System (ADS)

Chen, X.; Bohn, T. J.; Glagolev, M.; Maksyutov, S.; Lettenmaier, D. P.

2012-12-01

Lakes and wetlands are important sources of the greenhouse gases CO2 and CH4, whose emission rates are sensitive to climate. The northern high latitudes, which are especially susceptible to climate change, contain about 50% of the world's lakes and wetlands. With the predicted changes in the regional climate for this area within the next century, there is concern about a possible positive feedback resulting from greenhouse gas emissions (especially of methane) from the region's wetlands and lakes. To study the climate response to emissions from northern hemisphere lakes and wetlands, we have coupled a large-scale hydrology and carbon cycling model (University of Washington's Variable Infiltration Capacity model; VIC) with the atmospheric chemistry and transport model (CTM) of Japan's National Institute for Environmental Studies and have applied this modelling framework over the Pan-Arctic region. In particular, the VIC model simulates the land surface hydrology and carbon cycling across a dynamic lake-wetland continuum. The model includes a distributed wetland water table that accounts for microtopography and simulates variations in inundated area that are calibrated to match a passive microwave based inundation product. Per-unit-area carbon uptake and methane emissions have been calibrated using extensive in situ observations. In this paper, the atmospheric methane concentrations from a coupled run of VIC and CTM are calibrated and verified for the Pan-Arctic region with satellite observations from Aqua's Atmospheric Infrared Sounder (AIRS) and Envisat's Scanning Imaging Absorption Spectrometer for Atmospheric Cartography (SCIAMACHY) instruments. We examine relative emissions from lakes and wetlands, as well as their net greenhouse warming potential, over the last half-century across the Pan-Arctic domain. We also assess relative uncertainties in emissions from each of the sources.

Contractile effects and binding properties of endothelins/sarafotoxins in the guinea pig ileum.

PubMed

Wollberg, Z; Bdolah, A; Galron, R; Sokolovsky, M; Kochva, E

1991-05-30

Seven of the eight known isopeptides of the endothelin/sarafotoxin (ET/SRTX) family were tested on the isolated guinea pig ileum and found to cause a concentration-dependent increase in basal tone. The rate or the amplitude of the spontaneous rhythmic contractions of the ileal smooth muscle were essentially not affected by any of the peptides. The maximum contraction elicited by vasoactive intestinal contractor (VIC) was slightly stronger than that induced by endothelin-1 (ET-1) or sarafotoxin-b (SRTX-b), and significantly stronger than the maximal contractions elicited by sarafotoxin-a (SRTX-a), sarafotoxin-c (SRTX-c), or endothelin-3 (ET-3). Sarafotoxin-d (SRTX-d) caused, essentially, no contraction but a rather marked relaxation. The potencies of the various peptides to induce the increase in tension, in terms of EC50 values (cumulative effective concentrations that induce half-maximum response), ranged between 6 and 95 nM depending on the peptide. VIC, ET-1, SRTX-b and SRTX-a had similar potencies and were significantly more potent than SRTX-c and ET-3. A high concentration of SRTX-b elicited no additional response when applied to the organ bath after one of the other peptides had shown a maximal effect. Binding experiments with ileal membranes revealed similar binding properties for the various peptides. Competition with iodinated SRTX-b showed no meaningful differences between the various peptides. It is concluded that all the ET/SRTX peptides compete for the same receptor subtype in the ileum. In terms of efficacy, VIC can be considered as a full agonist of this receptor, SRTX-d is probably an antagonist, while all the other peptides behave as partial agonists.

Field methods to measure surface displacement and strain with the Video Image Correlation method

NASA Technical Reports Server (NTRS)

Maddux, Gary A.; Horton, Charles M.; Mcneill, Stephen R.; Lansing, Matthew D.

1994-01-01

The objective of this project was to develop methods and application procedures to measure displacement and strain fields during the structural testing of aerospace components using paint speckle in conjunction with the Video Image Correlation (VIC) system.

Veterinary Immunology Committee Toolkit Workshop 2010: Progress and plans

USDA-ARS?s Scientific Manuscript database

The Third Veterinary Immunology Committee (VIC) Toolkit Workshop took place at the Ninth International Veterinary Immunology Symposium (IVIS) in Tokyo, Japan on August 18, 2020. The Workshop built on previous Toolkit Workshops and covered various aspects of reagent development, commercialisation an...

A current perspective on availability of tools, resources and networks for veterinary immunology.

PubMed

Entrican, Gary; Lunney, Joan K; Rutten, Victor P; Baldwin, Cynthia L

2009-03-15

There are many diseases of fish, livestock and companion animals that impact negatively on animal health, welfare and productivity and for which there are no effective vaccines. The development of new vaccines is reliant on the availability of well-characterised immunological tools and reagents to understand host-pathogen interactions and identify protective immune responses. Veterinary immunology has always lagged behind mouse and human immunology in terms of development and availability of tools and reagents. However, several initiatives are underway to address this. The Veterinary Immunology Committee (VIC) Toolkit was initiated 6 years ago at the sixth International Veterinary Immunology Symposium (IVIS) in Uppsala and in the intervening period there have been several notable developments that have advanced reagent development and information exchange. This review will discuss advances in veterinary reagent development, networks, databases and commercial availability with particular reference to the second VIC Toolkit workshop held at the eighth IVIS in Ouro Preto, Brazil on the 15th of August 2007.

A Single-Channel EOG-Based Speller.

PubMed

He, Shenghong; Li, Yuanqing

2017-11-01

Electrooculography (EOG) signals, which can be used to infer the intentions of a user based on eye movements, are widely used in human-computer interface (HCI) systems. Most existing EOG-based HCI systems incorporate a limited number of commands because they generally associate different commands with a few different types of eye movements, such as looking up, down, left, or right. This paper presents a novel single-channel EOG-based HCI that allows users to spell asynchronously by only blinking. Forty buttons corresponding to 40 characters displayed to the user via a graphical user interface are intensified in a random order. To select a button, the user must blink his/her eyes in synchrony as the target button is flashed. Two data processing procedures, specifically support vector machine (SVM) classification and waveform detection, are combined to detect eye blinks. During detection, we simultaneously feed the feature vectors extracted from the ongoing EOG signal into the SVM classification and waveform detection modules. Decisions are made based on the results of the SVM classification and waveform detection. Three online experiments were conducted with eight healthy subjects. We achieved an average accuracy of 94.4% and a response time of 4.14 s for selecting a character in synchronous mode, as well as an average accuracy of 93.43% and a false positive rate of 0.03/min in the idle state in asynchronous mode. The experimental results, therefore, demonstrated the effectiveness of this single-channel EOG-based speller.

Questionnaire Construction Manual

DTIC Science & Technology

1976-07-01

fwiW ........ ..., „.,. , r-m-lili^fa^BMiai igMiit VI-C Page 3 1 Jul 76 (2) All questionnaire items should be gramatically correct. (3) All...kept in mind: a. All response alternatives should follow the stem both gramatically and logically, and if possible, be parallel in structure. b

Beyond the SCS curve number: A new stochastic spatial runoff approach

NASA Astrophysics Data System (ADS)

Bartlett, M. S., Jr.; Parolari, A.; McDonnell, J.; Porporato, A. M.

2015-12-01

The Soil Conservation Service curve number (SCS-CN) method is the standard approach in practice for predicting a storm event runoff response. It is popular because its low parametric complexity and ease of use. However, the SCS-CN method does not describe the spatial variability of runoff and is restricted to certain geographic regions and land use types. Here we present a general theory for extending the SCS-CN method. Our new theory accommodates different event based models derived from alternative rainfall-runoff mechanisms or distributions of watershed variables, which are the basis of different semi-distributed models such as VIC, PDM, and TOPMODEL. We introduce a parsimonious but flexible description where runoff is initiated by a pure threshold, i.e., saturation excess, that is complemented by fill and spill runoff behavior from areas of partial saturation. To facilitate event based runoff prediction, we derive simple equations for the fraction of the runoff source areas, the probability density function (PDF) describing runoff variability, and the corresponding average runoff value (a runoff curve analogous to the SCS-CN). The benefit of the theory is that it unites the SCS-CN method, VIC, PDM, and TOPMODEL as the same model type but with different assumptions for the spatial distribution of variables and the runoff mechanism. The new multiple runoff mechanism description for the SCS-CN enables runoff prediction in geographic regions and site runoff types previously misrepresented by the traditional SCS-CN method. In addition, we show that the VIC, PDM, and TOPMODEL runoff curves may be more suitable than the SCS-CN for different conditions. Lastly, we explore predictions of sediment and nutrient transport by applying the PDF describing runoff variability within our new framework.

Pathfinder, Volume 7, Number 5, September/October 2009. Charting the Sea and Sky

DTIC Science & Technology

2009-10-01

During the six-month season, ski-equipped LC-130s, the polar version of the C-130 Hercules transport plane, flew more than 8.7 million pounds of...collaborate closely with the Space and Naval Warfare Systems Command (SPAWAR), Office of Polar Programs; the Federal Avia- tion Administration (FAA...only worldwide vector chart coverage. Recently, the Navy implemented polar navigation using NGA charts and is now capable of true worldwide digital

The Streptococcus mutans Serine/Threonine Kinase, PknB, Regulates Competence Development, Bacteriocin Production, and Cell Wall Metabolism ▿

PubMed Central

Banu, Liliana Danusia; Conrads, Georg; Rehrauer, Hubert; Hussain, Haitham; Allan, Elaine; van der Ploeg, Jan R.

2010-01-01

Bacteria can detect, transmit, and react to signals from the outside world by using two-component systems (TCS) and serine-threonine kinases and phosphatases. Streptococcus mutans contains one serine-threonine kinase, encoded by pknB. A gene encoding a serine-threonine phosphatase, pppL, is located upstream of pknB. In this study, the phenotypes of pknB and pppL single mutants and a pknB pppL double mutant were characterized. All mutants exhibited a reduction in genetic transformability and biofilm formation, showed abnormal cell shapes, grew slower than the wild-type strain in several complex media, and exhibited reduced acid tolerance. The mutants had reduced cariogenic capacity but no significant defects in colonization in a rat caries model. Whole-genome transcriptome analysis revealed that a pknB mutant showed reduced expression of genes involved in bacteriocin production and genetic competence. Among the genes that were differentially regulated in the pknB mutant, several were likely to be involved in cell wall metabolism. One such gene, SMU.2146c, and two genes encoding bacteriocins were shown to also be downregulated in a vicK mutant, which encodes a sensor kinase involved in the response to oxidative stress. Collectively, the results lead us to speculate that PknB may modulate the activity of the two-component signal transduction systems VicKR and ComDE. Real-time reverse transcriptase PCR (RT-PCR) showed that genes downregulated in the pknB mutant were upregulated in the pppL mutant, indicating that PppL serves to counteract PknB. PMID:20231406

The Streptococcus mutans serine/threonine kinase, PknB, regulates competence development, bacteriocin production, and cell wall metabolism.

PubMed

Banu, Liliana Danusia; Conrads, Georg; Rehrauer, Hubert; Hussain, Haitham; Allan, Elaine; van der Ploeg, Jan R

2010-05-01

Bacteria can detect, transmit, and react to signals from the outside world by using two-component systems (TCS) and serine-threonine kinases and phosphatases. Streptococcus mutans contains one serine-threonine kinase, encoded by pknB. A gene encoding a serine-threonine phosphatase, pppL, is located upstream of pknB. In this study, the phenotypes of pknB and pppL single mutants and a pknB pppL double mutant were characterized. All mutants exhibited a reduction in genetic transformability and biofilm formation, showed abnormal cell shapes, grew slower than the wild-type strain in several complex media, and exhibited reduced acid tolerance. The mutants had reduced cariogenic capacity but no significant defects in colonization in a rat caries model. Whole-genome transcriptome analysis revealed that a pknB mutant showed reduced expression of genes involved in bacteriocin production and genetic competence. Among the genes that were differentially regulated in the pknB mutant, several were likely to be involved in cell wall metabolism. One such gene, SMU.2146c, and two genes encoding bacteriocins were shown to also be downregulated in a vicK mutant, which encodes a sensor kinase involved in the response to oxidative stress. Collectively, the results lead us to speculate that PknB may modulate the activity of the two-component signal transduction systems VicKR and ComDE. Real-time reverse transcriptase PCR (RT-PCR) showed that genes downregulated in the pknB mutant were upregulated in the pppL mutant, indicating that PppL serves to counteract PknB.

Trajectory and Aeroheating Environment Development and Sensitivity Analysis for Capsule-shaped Vehicles

NASA Technical Reports Server (NTRS)

Robinson, Jeffrey S.; Wurster, Kathryn E.

2006-01-01

Recently, NASA's Exploration Systems Research and Technology Project funded several tasks that endeavored to develop and evaluate various thermal protection systems and high temperature material concepts for potential use on the crew exploration vehicle. In support of these tasks, NASA Langley's Vehicle Analysis Branch generated trajectory information and associated aeroheating environments for more than 60 unique entry cases. Using the Apollo Command Module as the baseline entry system because of its relevance to the favored crew exploration vehicle design, trajectories for a range of lunar and Mars return, direct and aerocapture Earth-entry scenarios were developed. For direct entry, a matrix of cases was created that reflects reasonably expected minimum and maximum values of vehicle ballistic coefficient, inertial velocity at entry interface, and inertial flight path angle at entry interface. For aerocapture, trajectories were generated for a range of values of initial velocity and ballistic coefficient that, when combined with proper initial flight path angles, resulted in achieving a low Earth orbit either by employing a full lift vector up or full lift vector down attitude. For each trajectory generated, aeroheating environments were generated which were intended to bound the thermal protection system requirements for likely crew exploration vehicle concepts. The trades examined clearly pointed to a range of missions / concepts that will require ablative systems as well as a range for which reusable systems may be feasible. In addition, the results clearly indicated those entry conditions and modes suitable for manned flight, considering vehicle deceleration levels experienced during entry. This paper presents an overview of the analysis performed, including the assumptions, methods, and general approach used, as well as a summary of the trajectory and aerothermal environment information that was generated.

Lunar Reconnaissance Orbiter (LRO) Thruster Control Mode Design and Flight Experience

NASA Technical Reports Server (NTRS)

Hsu, Oscar C.

2010-01-01

National Aeronautics and Space Administration s (NASA) Goddard Space Flight Center (GSFC) in Greenbelt, MD, designed, built, tested, and launched the Lunar Reconnaissance Orbiter (LRO) from Cape Canaveral Air Force Station on June 18, 2009. The LRO spacecraft is the first operational spacecraft designed to support NASA s return to the Moon, as part of the Vision for Space Exploration. LRO was launched aboard an Atlas V 401 launch vehicle into a direct insertion trajectory to the Moon. Twenty-four hours after separation the propulsion system was used to perform a mid-course correction maneuver. Four days after the mid-course correction a series of propulsion maneuvers were executed to insert LRO into its commissioning orbit. The commission period lasted eighty days and this followed by a second set of thruster maneuvers that inserted LRO into its mission orbit. To date, the spacecraft has been gathering invaluable data in support of human s future return to the moon. The LRO Attitude Control Systems (ACS) contains two thruster based control modes: Delta-H and Delta-V. The design of the two controllers are similar in that they are both used for 3-axis control of the spacecraft with the Delta-H controller used for momentum management and the Delta-V controller used for orbit adjust and maintenance maneuvers. In addition to the nominal purpose of the thruster modes, the Delta-H controller also has the added capability of performing a large angle slew maneuver. A suite of ACS components are used by the thruster based control modes, for both initialization and control. For initialization purposes, a star tracker or the Kalman Filter solution is used for providing attitude knowledge and upon entrance into the thruster based control modes attitude knowledge is provided via rate propagation using a inertial reference unit (IRU). Rate information for the controller is also supplied by the IRU. Three-axis control of the spacecraft in the thruster modes is provided by eight 5-lbf class attitude control thrusters configured in two sets of four thrusters for redundancy purposes. Four additional 20-lbf class thrusters configured in two sets of two thrusters are used for Lunar Orbit Insertion maneuvers. The propulsion system is one the few systems on-board the LRO spacecraft that has built in redundancy. The Delta-H controller consists of a Proportional-Derivative (PD) controller with a structural filter on the thrusters and a Proportional controller on the reaction wheels. The PD control that employs the thrusters is used for attitude and rate control. The Proportional controller on the reaction wheels is used for commanding the wheels to a new momentum state. The ground commands used for the Delta-H controller are the system momentum vector, reaction wheel momentum, maximum expected command time, and which set of attitude control thrusters to use. The ability to command both the system momentum vector and reaction wheel momentum in the Delta-H controller provides both a capability and an additional source of operator error. Large angle slews via the Delta-H controller is achievable via this commands because these commands are used for the exit mode criteria. Setting these commands to non-consistent values prevents the mode from exiting nominally.

Limonene inhibits streptococcal biofilm formation by targeting surface-associated virulence factors.

PubMed

Subramenium, Ganapathy Ashwinkumar; Vijayakumar, Karuppiah; Pandian, Shunmugiah Karutha

2015-08-01

The present study explores the efficacy of limonene, a cyclic terpene found in the rind of citrus fruits, for antibiofilm potential against species of the genus Streptococcus, which have been deeply studied worldwide owing to their multiple pathogenic efficacy. Limonene showed a concentration-dependent reduction in the biofilm formation of Streptococcus pyogenes (SF370), with minimal biofilm inhibitory concentration (MBIC) of 400 μg ml - 1. Limonene was found to possess about 75-95 % antibiofilm activity against all the pathogens tested, viz. Streptococcus pyogenes (SF370 and 5 clinical isolates), Streptococcus mutans (UA159) and Streptococcus mitis (ATCC 6249) at 400 μg ml - 1 concentration. Microscopic analysis of biofilm architecture revealed a quantitative breach in biofilm formation. Results of a surface-coating assay suggested that the possible mode of action of limonene could be by inhibiting bacterial adhesion to surfaces, thereby preventing the biofilm formation cascade. Susceptibility of limonene-treated Streptococcus pyogenes to healthy human blood goes in unison with gene expression studies in which the mga gene was found to be downregulated. Anti-cariogenic efficacy of limonene against Streptococcus mutans was confirmed, with inhibition of acid production and downregulation of the vicR gene. Downregulation of the covR, mga and vicR genes, which play a critical role in regulating surface-associated proteins in Streptococcus pyogenes and Streptococcus mutans, respectively, is yet further evidence to show that limonene targets surface-associated proteins. The results of physiological assays and gene expression studies clearly show that the surface-associated antagonistic mechanism of limonene also reduces surface-mediated virulence factors.

Concerning Ken Hines …

NASA Astrophysics Data System (ADS)

McKellar, Bruce H. J.; Amos, Ken

The following sections are included: * Obituary published in the `Age' newspaper * Curriculum vitae: Kenneth Charles Hines * Some short stories about Ken * Roger Hosking reminisces * Ken Amos reminisces * Vic Kowalenko reminisces * Zwi Barnea reminisces * "Legend's" Thursday lunch club award number four * Graeme Lister reminisces * Bob Dewar reminisces * Norm Frankel reminisces

ARC-1986-AC86-0746-2

NASA Image and Video Library

1986-10-10

Ames Director William 'Bill' Ballhaus (center left) joins visitor Sir Jeffrey Pope from Royla Aircraft Industry, England (center right) at the NAS Facility Cray 2 computer with Ron Deiss, NAS Deputy Manager (L) and Vic Peterson, Ames Deputy Director (R).

GRAMPS: a graphics language interpreter for real-time, interactive, three-dimensional picture editing and animation

DOE Office of Scientific and Technical Information (OSTI.GOV)

O'Donnell, T.J.; Olson, A.J.

1981-08-01

GRAMPS, a graphics language interpreter has been developed in FORTRAN 77 to be used in conjunction with an interactive vector display list processor (Evans and Sutherland Multi-Picture-System). Several of the features of the language make it very useful and convenient for real-time scene construction, manipulation and animation. The GRAMPS language syntax allows natural interaction with scene elements as well as easy, interactive assignment of graphics input devices. GRAMPS facilitates the creation, manipulation and copying of complex nested picture structures. The language has a powerful macro feature that enables new graphics commands to be developed and incorporated interactively. Animation may bemore » achieved in GRAMPS by two different, yet mutually compatible means. Picture structures may contain framed data, which consist of a sequence of fixed objects. These structures may be displayed sequentially to give a traditional frame animation effect. In addition, transformation information on picture structures may be saved at any time in the form of new macro commands that will transform these structures from one saved state to another in a specified number of steps, yielding an interpolated transformation animation effect. An overview of the GRAMPS command structure is given and several examples of application of the language to molecular modeling and animation are presented.« less

MatLab Script and Functional Programming

NASA Technical Reports Server (NTRS)

Shaykhian, Gholam Ali

2007-01-01

MatLab Script and Functional Programming: MatLab is one of the most widely used very high level programming languages for scientific and engineering computations. It is very user-friendly and needs practically no formal programming knowledge. Presented here are MatLab programming aspects and not just the MatLab commands for scientists and engineers who do not have formal programming training and also have no significant time to spare for learning programming to solve their real world problems. Specifically provided are programs for visualization. The MatLab seminar covers the functional and script programming aspect of MatLab language. Specific expectations are: a) Recognize MatLab commands, script and function. b) Create, and run a MatLab function. c) Read, recognize, and describe MatLab syntax. d) Recognize decisions, loops and matrix operators. e) Evaluate scope among multiple files, and multiple functions within a file. f) Declare, define and use scalar variables, vectors and matrices.

PyKE3: data analysis tools for NASA's Kepler, K2, and TESS missions

NASA Astrophysics Data System (ADS)

Hedges, Christina L.; Cardoso, Jose Vinicius De Miranda; Barentsen, Geert; Gully-Santiago, Michael A.; Cody, Ann Marie; Barclay, Thomas; Still, Martin; BAY AREA ENVIRONMENTAL RESEARCH IN

2018-01-01

The PyKE package is a set of easy to use tools for working with Kepler/K2 data. This includes tools to correct light curves for cotrending basis vectors, turn the raw Target Pixel File data into motion corrected light curves, check for exoplanet false positives and run new PSF photometry. We are now releasing PyKE 3, which is compatible with Python 3, is pip installable and no longer depends on PyRAF. Tools are available both as Python routines and from the command line. New tutorials are available and under construction for users to learn about Kepler and K2 data and how to best use it for their science goals. PyKE is open source and welcomes contributions from the community. Routines and more information are available on the PyKE repository on GitHub.

Heart Valve Biomechanics and Underlying Mechanobiology

PubMed Central

Ayoub, Salma; Ferrari, Giovanni; Gorman, Robert C.; Gorman, Joseph H.; Schoen, Frederick J.; Sacks, Michael S.

2017-01-01

Heart valves control unidirectional blood flow within the heart during the cardiac cycle. They have a remarkable ability to withstand the demanding mechanical environment of the heart, achieving lifetime durability by processes involving the ongoing remodeling of the extracellular matrix. The focus of this review is on heart valve functional physiology, with insights into the link between disease-induced alterations in valve geometry, tissue stress, and the subsequent cell mechanobiological responses and tissue remodeling. We begin with an overview of the fundamentals of heart valve physiology and the characteristics and functions of valve interstitial cells (VICs). We then provide an overview of current experimental and computational approaches that connect VIC mechanobiological response to organ- and tissue-level deformations and improve our understanding of the underlying functional physiology of heart valves. We conclude with a summary of future trends and offer an outlook for the future of heart valve mechanobiology, specifically, multiscale modeling approaches, and the potential directions and possible challenges of research development. PMID:27783858

Ion Implantation Metallurgy.

DTIC Science & Technology

1979-03-01

cause of these discrepancies seem adequately explained by radiation-enhanced diff- fussion of Ni and Cr in opposite directions. (3) The SACM produced...J. M. Scharff and H. E. Schiott, KGL. DAN. VIC. SELSK. M.ATT-FYS. MEDD., 33, 14 (1963). 8. P. R. Okamoto and H. Wiedersich, J. of Nuclear Materials

Project SERAPHIM Report.

ERIC Educational Resources Information Center

Moore, John W.

1983-01-01

Lists and briefly describes computer programs recently added to those currently available from Project SERAPHIM. Program name, subject, hardware, author, supplier, and cost are provided in separate listings for Apple, PET, TRS-80 I or III, IBM, VIC-20, TERAK, and PDP-11 microcomputers. Includes corrections for two current Apple programs. (JN)

Research Using ASDC Data Products

Atmospheric Science Data Center

2013-04-18

Research using ASDC Data Products   Please Contact Us if you would like to contribute your research.     "An investigation into the performance of ... data," (PDF 4MB) Stuart A. Young, C.S.I.R.O. Atmospheric Research, Aspendale, VIC, Australia. Photosynthetically Active ...

CHRIS: Hazardous Chemical Data

DTIC Science & Technology

1978-10-01

CPLORD-O-TOLUICIfE FAST RED Z& BASE = ’-1-ITRCAMILINE FERMENTAITION ALCOH!OL - ETHYL ALCOHOL FERMENTATION AMYL ALCOHCL -ISCANYL ALCOJIGI FERMENTATION BUTYL...ACID ETHYLENEDIAMINE IETRACETIC ACID VIC-H-XYLENOL XYLENOL VIENNA GREEN COPPER ACETOARSE1ITE VILRATHANE 4300 -CIPHENYLETHAME01ISOCYANATE (MDIl VINEGAR

Independent Orbiter Assessment (IOA): Analysis of the guidance, navigation, and control subsystem

NASA Technical Reports Server (NTRS)

Trahan, W. H.; Odonnell, R. A.; Pietz, K. C.; Hiott, J. M.

1986-01-01

The results of the Independent Orbiter Assessment (IOA) of the Failure Modes and Effects Analysis (FMEA) and Critical Items List (CIL) is presented. The IOA approach features a top-down analysis of the hardware to determine failure modes, criticality, and potential critical items. To preserve independence, this analysis was accomplished without reliance upon the results contained within the NASA FMEA/CIL documentation. The independent analysis results corresponding to the Orbiter Guidance, Navigation, and Control (GNC) Subsystem hardware are documented. The function of the GNC hardware is to respond to guidance, navigation, and control software commands to effect vehicle control and to provide sensor and controller data to GNC software. Some of the GNC hardware for which failure modes analysis was performed includes: hand controllers; Rudder Pedal Transducer Assembly (RPTA); Speed Brake Thrust Controller (SBTC); Inertial Measurement Unit (IMU); Star Tracker (ST); Crew Optical Alignment Site (COAS); Air Data Transducer Assembly (ADTA); Rate Gyro Assemblies; Accelerometer Assembly (AA); Aerosurface Servo Amplifier (ASA); and Ascent Thrust Vector Control (ATVC). The IOA analysis process utilized available GNC hardware drawings, workbooks, specifications, schematics, and systems briefs for defining hardware assemblies, components, and circuits. Each hardware item was evaluated and analyzed for possible failure modes and effects. Criticality was assigned based upon the severity of the effect for each failure mode.

The Evolution of Army Leader Development

DTIC Science & Technology

2013-03-01

Human Resources Command, OPMD- MFE -I. 4 U.S. Army General Officer Management Office, Army General Officer Roster (Washington, DC, U.S. Department of the...Human Resources Command, Command Management Branch post board data analysis. 15 Data from the United States Army Human Resources Command, OPMD- MFE -A...May 1, 2008), D-1. 25 19 Data from the United States Army Human Resources Command, OPMD- MFE -A, 01 February, 2013. 20 U.S. Joint Chiefs of

Mission Command and the United States Navy: Overcoming Doctrinal Hurdles to Enable Mission Command

DTIC Science & Technology

2017-05-12

Press, 2000), 40-44. 13 Carl H. Builder. The Masks of War: American Military Styles in Strategy and Analysis. (Baltimore: Johns Hopkins University...mission command’ clearly represents a ‘mission-specific’ style of command and control, while ‘command by negation’ more clearly represents an...objective-specific’ style . Differing Approaches Create Differing Outcomes Each of the three comparisons above demonstrate that ‘mission command’ and

VizieR Online Data Catalog: VIc photometry of IR-excess stars in NGC6611 (De Marchi+ 2013)

NASA Astrophysics Data System (ADS)

de Marchi, G.; Panagia, N.; Guarcello, M. G.; Bonito, R.

2014-10-01

The data analysed in this work were extracted from the multiband photometric catalogue of NGC 6611 and of the surrounding M 16 cloud compiled by Guarcello et al. (2010, Cat. J/A+A/521/A61). (1 data file).

Command Process Modeling & Risk Analysis

NASA Technical Reports Server (NTRS)

Meshkat, Leila

2011-01-01

Commanding Errors may be caused by a variety of root causes. It's important to understand the relative significance of each of these causes for making institutional investment decisions. One of these causes is the lack of standardized processes and procedures for command and control. We mitigate this problem by building periodic tables and models corresponding to key functions within it. These models include simulation analysis and probabilistic risk assessment models.

Opportunities Seized and Squandered: An Analysis of Joint Union and Confederate Operations at New Madrid and Island Number Ten

DTIC Science & Technology

2016-06-10

install a command structure , and identify strategies for their geographic commanders. In the Western Theater of the war, both Northern and Southern...Federal and Confederate militaries had to mobilize forces, install a command structure , and identify strategies for their geographic commanders. In...Navy officers avoided these operations with their intermittent periods of importance. The lack of an enduring force structure and a consistent

General Matthew B. Ridgway: Attributes of Battle Command and Decision-Making

DTIC Science & Technology

1998-02-13

information dominance require the attributes of future battle commanders be different than those of the past? This paper focuses on the intellectual and personality traits of General Matthew B. Ridgway as they apply to operational command and decision-making. These traits are considered essential for analysis and serve as a framework in which to examine their applicability to future command. The essential qualities of an operational commander are divided into two categories: intellect and personality. Each category is further divided into elemental traits. The application

Role of the Streptococcus mutans CRISPR-Cas Systems in Immunity and Cell Physiology

PubMed Central

Serbanescu, M. A.; Cordova, M.; Krastel, K.; Flick, R.; Beloglazova, N.; Latos, A.; Yakunin, A. F.; Senadheera, D. B.

2014-01-01

CRISPR-Cas systems provide adaptive microbial immunity against invading viruses and plasmids. The cariogenic bacterium Streptococcus mutans UA159 has two CRISPR-Cas systems: CRISPR1 (type II-A) and CRISPR2 (type I-C) with several spacers from both CRISPR cassettes matching sequences of phage M102 or genomic sequences of other S. mutans. The deletion of the cas genes of CRISPR1 (ΔC1S), CRISPR2 (ΔC2E), or both CRISPR1+2 (ΔC1SC2E) or the removal of spacers 2 and 3 (ΔCR1SP13E) in S. mutans UA159 did not affect phage sensitivity when challenged with virulent phage M102. Using plasmid transformation experiments, we demonstrated that the CRISPR1-Cas system inhibits transformation of S. mutans by the plasmids matching the spacers 2 and 3. Functional analysis of the cas deletion mutants revealed that in addition to a role in plasmid targeting, both CRISPR systems also contribute to the regulation of bacterial physiology in S. mutans. Compared to wild-type cells, the ΔC1S strain displayed diminished growth under cell membrane and oxidative stress, enhanced growth under low pH, and had reduced survival under heat shock and DNA-damaging conditions, whereas the ΔC2E strain exhibited increased sensitivity to heat shock. Transcriptional analysis revealed that the two-component signal transduction system VicR/K differentially modulates expression of cas genes within CRISPR-Cas systems, suggesting that VicR/K might coordinate the expression of two CRISPR-Cas systems. Collectively, we provide in vivo evidence that the type II-A CRISPR-Cas system of S. mutans may be targeted to manipulate its stress response and to influence the host to control the uptake and dissemination of antibiotic resistance genes. PMID:25488301

Reduced state feedback gain computation. [optimization and control theory for aircraft control

NASA Technical Reports Server (NTRS)

Kaufman, H.

1976-01-01

Because application of conventional optimal linear regulator theory to flight controller design requires the capability of measuring and/or estimating the entire state vector, it is of interest to consider procedures for computing controls which are restricted to be linear feedback functions of a lower dimensional output vector and which take into account the presence of measurement noise and process uncertainty. Therefore, a stochastic linear model that was developed is presented which accounts for aircraft parameter and initial uncertainty, measurement noise, turbulence, pilot command and a restricted number of measurable outputs. Optimization with respect to the corresponding output feedback gains was performed for both finite and infinite time performance indices without gradient computation by using Zangwill's modification of a procedure originally proposed by Powell. Results using a seventh order process show the proposed procedures to be very effective.

MultiElec: A MATLAB Based Application for MEA Data Analysis.

PubMed

Georgiadis, Vassilis; Stephanou, Anastasis; Townsend, Paul A; Jackson, Thomas R

2015-01-01

We present MultiElec, an open source MATLAB based application for data analysis of microelectrode array (MEA) recordings. MultiElec displays an extremely user-friendly graphic user interface (GUI) that allows the simultaneous display and analysis of voltage traces for 60 electrodes and includes functions for activation-time determination, the production of activation-time heat maps with activation time and isoline display. Furthermore, local conduction velocities are semi-automatically calculated along with their corresponding vector plots. MultiElec allows ad hoc signal suppression, enabling the user to easily and efficiently handle signal artefacts and for incomplete data sets to be analysed. Voltage traces and heat maps can be simply exported for figure production and presentation. In addition, our platform is able to produce 3D videos of signal progression over all 60 electrodes. Functions are controlled entirely by a single GUI with no need for command line input or any understanding of MATLAB code. MultiElec is open source under the terms of the GNU General Public License as published by the Free Software Foundation, version 3. Both the program and source code are available to download from http://www.cancer.manchester.ac.uk/MultiElec/.

26 CFR 1.469-0 - Table of contents.

Code of Federal Regulations, 2010 CFR

2010-04-01

... for investment. (C) Property used in a trade or business. (D) Lodging rented for convenience of...)(3)-(e)(1) [Reserved] (2) Trade or business activity. (e)(3)(i)-(e)(3)(ii) [Reserved] (iii) Average... rent. (e)(3)(iv)-(e)(3)(vi)(C) [Reserved] (D) Lodging rented for convenience of employer. (E...

Three-dimensional tool radius compensation for multi-axis peripheral milling

NASA Astrophysics Data System (ADS)

Chen, Youdong; Wang, Tianmiao

2013-05-01

Few function about 3D tool radius compensation is applied to generating executable motion control commands in the existing computer numerical control (CNC) systems. Once the tool radius is changed, especially in the case of tool size changing with tool wear in machining, a new NC program has to be recreated. A generic 3D tool radius compensation method for multi-axis peripheral milling in CNC systems is presented. The offset path is calculated by offsetting the tool path along the direction of the offset vector with a given distance. The offset vector is perpendicular to both the tangent vector of the tool path and the orientation vector of the tool axis relative to the workpiece. The orientation vector equations of the tool axis relative to the workpiece are obtained through homogeneous coordinate transformation matrix and forward kinematics of generalized kinematics model of multi-axis machine tools. To avoid cutting into the corner formed by the two adjacent tool paths, the coordinates of offset path at the intersection point have been calculated according to the transition type that is determined by the angle between the two tool path tangent vectors at the corner. Through the verification by the solid cutting simulation software VERICUT® with different tool radiuses on a table-tilting type five-axis machine tool, and by the real machining experiment of machining a soup spoon on a five-axis machine tool with the developed CNC system, the effectiveness of the proposed 3D tool radius compensation method is confirmed. The proposed compensation method can be suitable for all kinds of three- to five-axis machine tools as a general form.

Design and Integration of an Actuated Nose Strake Control System

NASA Technical Reports Server (NTRS)

Flick, Bradley C.; Thomson, Michael P.; Regenie, Victoria A.; Wichman, Keith D.; Pahle, Joseph W.; Earls, Michael R.

1996-01-01

Aircraft flight characteristics at high angles of attack can be improved by controlling vortices shed from the nose. These characteristics have been investigated with the integration of the actuated nose strakes for enhanced rolling (ANSER) control system into the NASA F-18 High Alpha Research Vehicle. Several hardware and software systems were developed to enable performance of the research goals. A strake interface box was developed to perform actuator control and failure detection outside the flight control computer. A three-mode ANSER control law was developed and installed in the Research Flight Control System. The thrust-vectoring mode does not command the strakes. The strakes and thrust-vectoring mode uses a combination of thrust vectoring and strakes for lateral- directional control, and strake mode uses strakes only for lateral-directional control. The system was integrated and tested in the Dryden Flight Research Center (DFRC) simulation for testing before installation in the aircraft. Performance of the ANSER system was monitored in real time during the 89-flight ANSER flight test program in the DFRC Mission Control Center. One discrepancy resulted in a set of research data not being obtained. The experiment was otherwise considered a success with the majority of the research objectives being met.

Utilization of a Multi-Disciplinary Approach to Building Effective Command Centers: Process and Products

DTIC Science & Technology

2005-06-01

cognitive task analysis , organizational information dissemination and interaction, systems engineering, collaboration and communications processes, decision-making processes, and data collection and organization. By blending these diverse disciplines command centers can be designed to support decision-making, cognitive analysis, information technology, and the human factors engineering aspects of Command and Control (C2). This model can then be used as a baseline when dealing with work in areas of business processes, workflow engineering, information management,

An introduction to MATLAB.

PubMed

Sobie, Eric A

2011-09-13

This two-part lecture introduces students to the scientific computing language MATLAB. Prior computer programming experience is not required. The lectures present basic concepts of computer programming logic that tend to cause difficulties for beginners in addition to concepts that relate specifically to the MATLAB language syntax. The lectures begin with a discussion of vectors, matrices, and arrays. Because many types of biological data, such as fluorescence images and DNA microarrays, are stored as two-dimensional objects, processing these data is a form of array manipulation, and MATLAB is especially adept at handling such array objects. The students are introduced to basic commands in MATLAB, as well as built-in functions that provide useful shortcuts. The second lecture focuses on the differences between MATLAB scripts and MATLAB functions and describes when one method of programming organization might be preferable to the other. The principles are illustrated through the analysis of experimental data, specifically measurements of intracellular calcium concentration in live cells obtained using confocal microscopy.

An Introduction to MATLAB

PubMed Central

Sobie, Eric A.

2014-01-01

This two-part lecture introduces students to the scientific computing language MATLAB. Prior computer programming experience is not required. The lectures present basic concepts of computer programming logic that tend to cause difficulties for beginners in addition to concepts that relate specifically to the MATLAB language syntax. The lectures begin with a discussion of vectors, matrices, and arrays. Because many types of biological data, such as fluorescence images and DNA microarrays, are stored as two-dimensional objects, processing these data is a form of array manipulation, and MATLAB is especially adept at handling such array objects. The students are introduced to basic commands in MATLAB, as well as built-in functions that provide useful shortcuts. The second lecture focuses on the differences between MATLAB scripts and MATLAB functions and describes when one method of programming organization might be preferable to the other. The principles are illustrated through the analysis of experimental data, specifically measurements of intracellular calcium concentration in live cells obtained using confocal microscopy. PMID:21934110

Microwave-Assisted Debromination of α-Bromoketones with Triarylstibanes in Water.

PubMed

Murata, Yuki; Sugawara, Yoshiyuki; Matsumura, Mio; Kakusawa, Naoki; Yasuike, Shuji

2017-01-01

Several α-bromoarylketones were reacted with triarylstibanes under microwave irradiation in water to obtain the corresponding debrominated ketones. Under similar reaction conditions, 1,2-elimination of vic-dibromides in water afforded the corresponding E-olefins. This reaction is the first example of organoantimony compounds utilized for organic transformation in water.

Comparing large-scale hydrological model predictions with observed streamflow in the Pacific Northwest: effects of climate and groundwater

Treesearch

Mohammad Safeeq; Guillaume S. Mauger; Gordon E. Grant; Ivan Arismendi; Alan F. Hamlet; Se-Yeun Lee

2014-01-01

Assessing uncertainties in hydrologic models can improve accuracy in predicting future streamflow. Here, simulated streamflows using the Variable Infiltration Capacity (VIC) model at coarse (1/16°) and fine (1/120°) spatial resolutions were evaluated against observed streamflows from 217 watersheds. In...

Seeing Through the Fog: The Evolution of Problem Framing in United States Army Decision-Making Doctrine

DTIC Science & Technology

2014-05-22

Commander and Staff 2: Mission Analysis 3: Mission analysis 3: Course of Action (COA) Development 4: Staff Estimates 4: COA Analysis 5: Commander’s...Commander and Staff 2: Mission Analysis 2: Mission Analysis 3: Mission analysis 3: Course of Action (COA) Development 3: Course of Action (COA... Development 4: Staff Estimates 4: COA Analysis 4: COA Analysis 5: Commander’s Estimate 5: COA Comparison 5: COA Comparison 6: Preparation

Is the Pearl River basin, China, drying or wetting? Seasonal variations, causes and implications

NASA Astrophysics Data System (ADS)

Zhang, Qiang; Li, Jianfeng; Gu, Xihui; Shi, Peijun

2018-07-01

Soil moisture plays crucial roles in the hydrological cycle and is also a critical link between land surface and atmosphere. The Pearl River basin (PRb) is climatically subtropical and tropical and is highly sensitive to climate changes. In this study, seasonal soil moisture changes across the PRb were analyzed using the Variable Infiltration Capacity (VIC) model forced by the gridded 0.5° × 0.5° climatic observations. Seasonal changes of soil moisture in both space and time were investigated using the Mann-Kendall trend test method. Potential influencing factors behind seasonal soil moisture changes such as precipitation and temperature were identified using the Maximum Covariance Analysis (MCA) technique. The results indicated that: (1) VIC model performs well in describing changing properties of soil moisture across the PRb; (2) Distinctly different seasonal features of soil moisture can be observed. Soil moisture in spring decreased from east to west parts of the PRb. In summer however, soil moisture was higher in east and west parts but was lower in central parts of the PRb; (3) A significant drying trend was identified over the PRb in autumn, while no significant drying trends can be detected in other seasons; (4) The increase/decrease in precipitation can generally explain the wetting/drying tendency of soil moisture. However, warming temperature contributed significantly to the drying trends and these drying trends were particularly evident during autumn and winter; (5) Significant decreasing precipitation and increasing temperature combined to trigger substantially decreasing soil moisture in autumn. In winter, warming temperature is the major reason behind decreased soil moisture although precipitation is in slightly decreasing tendency. Season variations of soil moisture and related implications for hydro-meteorological processes in the subtropical and tropical river basins over the globe should arouse considerable human concerns.

Feedback control laws for highly maneuverable aircraft

NASA Technical Reports Server (NTRS)

Garrard, William L.; Balas, Gary J.

1995-01-01

During this year, we concentrated our efforts on the design of controllers for lateral/directional control using mu synthesis. This proved to be a more difficult task than we anticipated and we are still working on the designs. In the lateral-directional control problem, the inputs are pilot lateral stick and pedal commands and the outputs are roll rate about the velocity vector and side slip angle. The control effectors are ailerons, rudder deflection, and directional thrust vectoring vane deflection which produces a yawing moment about the body axis. Our math model does not contain any provision for thrust vectoring of rolling moment. This has resulted in limitations of performance at high angles of attack. During 1994-95, the following tasks for the lateral-directional controllers were accomplished: (1) Designed both inner and outer loop dynamic inversion controllers. These controllers are implemented using accelerometer outputs rather than an a priori model of the vehicle aerodynamics; (2) Used classical techniques to design controllers for the system linearized by dynamics inversion. These controllers acted to control roll rate and Dutch roll response; (3) Implemented the inner loop dynamic inversion and classical controllers on the six DOF simulation; (4) Developed a lateral-directional control allocation scheme based on minimizing required control effort among the ailerons, rudder, and directional thrust vectoring; and (5) Developed mu outer loop controllers combined with classical inner loop controllers.

Effect of cross-correlation on track-to-track fusion

NASA Astrophysics Data System (ADS)

Saha, Rajat K.

1994-07-01

Since the advent of target tracking systems employing a diverse mixture of sensors, there has been increasing recognition by air defense system planners and other military system analysts of the need to integrate these tracks so that a clear air picture can be obtained in a command center. A popular methodology to achieve this goal is to perform track-to-track fusion, which performs track-to-track association as well as kinematic state vector fusion. This paper seeks to answer analytically the extent of improvement achievable by means of kinetic state vector fusion when the tracks are obtained from dissimilar sensors (e.g., Radar/ESM/IRST/IFF). It is well known that evaluation of the performance of state vector fusion algorithms at steady state must take into account the effects of cross-correlation between eligible tracks introduced by the input noise which, unfortunately, is often neglected because of added computational complexity. In this paper, an expression for the steady-state cross-covariance matrix for a 2D state vector track-to-track fusion is obtained. This matrix is shown to be a function of the parameters of the Kalman filters associated with the candidate tracks being fused. Conditions for positive definiteness of the cross-covariance matrix have been derived and the effect of positive definiteness on performance of track-to-track fusion is also discussed.

How Might Recharge Change Under Projected Climate Change in Western US?

NASA Astrophysics Data System (ADS)

Niraula, R.; Meixner, T.; Rodell, M.; Ajami, H.; Gochis, D. J.; Castro, C. L.

2015-12-01

Although ground water is a major source of water in the western US, little research has been done on the impacts of climate change on western groundwater storage and recharge. Here we assess the impact of projected changes in precipitation and temperature on groundwater recharge across the western US by dividing the domain into five major regions (viz. Northern Rockies and Plains, South, Southwest, Northwest and West). Hydrologic outputs from the Variable Infiltration Capacity (VIC) model based on Bias-Correction and Spatial Disaggregation (BCSD) Coupled Model Inter-comparison Project Phase 5 (CMIP5) climate projections from 11 Global Circulation Models (GCMs) for Representative Concentration pathway 6.0 (RCP 6.0) scenarios were selected for projecting changes in recharge. Projections are made for near future (2020-2050) and far future (2070-2100) relative to the historical period (1970-2000). Averaged over the domain, half of the GCMs caused VIC to increase recharge across the region while the remaining half resulted in decreased recharge for both the near (-10.1% to 5.8%) and far (-9.7% to 17%) future. A majority (9 out of 11 GCMs) of the VIC simulations projected increased recharge in the Northern Rockies and Plains for both the near and far future. A majority of the simulations agreed on reduced recharge in other regions for the near future. For the far future, a majority of the simulations agreed on decreased recharge in the South (9 out of 11 GCMs) and Southwest (7 out of 11 GCMs) regions. The change is projected to be largest for the South region which could see recharged reduced by as much as 50%. Changes in recharge in the Northwest region are predicted to be small (within 10% of historical recharge). Despite the large variability in projected recharge across the GCMs, recharge projections from this study will help water managers with long term water management planning.

Designing to Support Command and Control in Urban Firefighting

DTIC Science & Technology

2008-06-01

complex human- machine systems. Keywords: Command and control, firefighting, cognitive systems engineering, cognitive task analysis 1...Elm, W. (2000). Bootstrapping multiple converging cognitive task analysis techniques for system design. In J.M.C. Schraagen, S.F. Chipman, & V.L...Shalin, (Eds.), Cognitive Task Analysis . (pp. 317-340). Mahwah, NJ: Lawrence Erlbaum. Rasmussen, J., Pejtersen, A., Goodman, L. (1994). Cognitive

Anthropogenic modifications to drainage conditions on streamflow variability in the Wabash River basin, Indiana

NASA Astrophysics Data System (ADS)

Chiu, C.; Bowling, L. C.

2011-12-01

The Wabash River watershed is the largest watershed in Indiana and includes the longest undammed river reach east of the Mississippi River. The land use of the Wabash River basin began to significantly change from mixed woodland dominated by small lakes and wetlands to agriculture in the mid-1800s and agriculture is now the predominant land use. Over 80% of natural wetland areas were drained to facilitate better crop production through both surface and subsurface drainage applications. Quantifying the change in hydrologic response in this intensively managed landscape requires a hydrologic model that can represent wetlands, crop growth, and impervious area as well as subsurface and surface drainage enhancements, coupled with high resolution soil and topographic inputs. The Variable Infiltration Capacity (VIC) model wetland algorithm has been previously modified to incorporate spatially-varying estimates of water table distribution using a topographic index approach, as well as a simple urban representation. Now, the soil water characteristics curve and a derived drained to equilibrium moisture profile are used to improve the model's estimation of the water table. In order to represent subsurface (tile) drainage, the tile drainage component of subsurface flow is calculated when the simulated water table rises above a specified drain depth. A map of the current estimated extent of subsurface tile drainage for the Wabash River based on a decision tree classifier of soil drainage class, soil slope and agricultural land use is used to activate the new tile drainage feature in the VIC model, while wetland depressional storage capacity is extracted from digital elevation and soil information. This modified VIC model is used to evaluate the performance of model physical variations in the intensively managed hydrologic regime of the Wabash River system and to understand the role of surface and subsurface storage, and land use and land cover change on hydrologic change.

Model Estimate of Pan-Arctic Lakes and Wetlands Methane Emissions and Their Future Climate Response

NASA Astrophysics Data System (ADS)

Chen, X.; Bohn, T. J.; Maksyutov, S. S.; Lettenmaier, D. P.

2013-12-01

Lakes and wetlands are important sources of the greenhouse gas CH4, whose emission rate is sensitive to climate. The northern high latitudes, which are especially susceptible to climate change, contain about 50% of the world's lakes and wetlands. Given predicted changes in the climate of this region over the next century (IPCC AR5 scenarios), there is concern about a possible positive feedback resulting from methane emissions from the region's wetlands and lakes. To study the climate response of emissions from northern high latitude lakes and wetlands, we employed a large-scale hydrology and carbon cycling model (Variable Infiltration Capacity model; VIC) over the Pan-Arctic domain, which was linked to an atmospheric model (Japan's National Institute of Environmental Studies transport model; NIES TM). In particular, the VIC model simulates the land surface hydrology and carbon cycling across a dynamic lake-wetland continuum, while NIES TM models the atmospheric mixing and 3-dimension transport of methane emitted. The VIC model includes a distributed wetland water table scheme, which accounts for microtopography around the lakes and simulates variations in inundated area that are calibrated to match a passive microwave based inundation product. Per-unit-area carbon uptake and methane emissions at the land surface have been calibrated using extensive in situ observations at West Siberia. Also, the atmospheric methane concentration from this linked model run was verified for the recent 5 years with satellite observations from Aqua's Atmospheric Infrared Sounder (AIRS) and Envisat's Scanning Imaging Absorption Spectrometer for Atmospheric Cartography (SCIAMACHY) instruments. Using RCP4.5 and RCP8.5 future climate scenarios, we examine CH4 emissions from high latitude lakes and wetlands, as well as their net greenhouse warming potential, over the next 3 centuries across the Pan-Arctic domain. We also assess relative uncertainties in emissions from each of the sources.

Large-Scale Simulation of the Effects of Climate Change on Runoff Erosion Following Extreme Wildfire Events Authors: Gould, Adam, Warren, Barber, Wagenbrenner, Robichaud, Wang, Cherkauer

NASA Astrophysics Data System (ADS)

Gould, G.; Adam, J. C.; Barber, M. E.; Wagenbrenner, J. W.; Robichaud, P. R.; Wang, L.; Cherkauer, K. A.

2012-12-01

Across the western U.S., there is clear concern for increases in wildfire occurrence, severity, and post-fire runoff erosion due to projected climate changes. The aim of this study was to advance our capability to simulate post-fire runoff erosion at scales larger than a single hillslope to examine the relative contribution of sediment being released to larger streams and rivers in response to wildfire. We applied the Variable Capacity Infiltration-Water Erosion Prediction Project (VIC-WEPP), a newly-developed physically-based modeling framework that combines large-scale hydrology with hillslope-scale runoff erosion, over the Salmon River basin (SRB) in central Idaho. We selected the SRB for this study because of recent research that suggested that forest wildfires are likely contributing the majority of coarser sands that settle in downstream navigation channels and in reservoirs, causing adverse impacts to aquatic life, navigation, and flood storage. Using the Normalized Burn Ratio (NBR), burn intensity and severity maps show the regularity of wildfire occurrence in the SRB. These maps compare pre-fire images to next growing season images from the Landsat Thematic Mapper multispectral scanning sensor. Rather than implementing WEPP over all hillslopes within the SRB, we applied a representative hillslope approach. A monofractal scaling method downscales globally available 30 arc second digital elevation model (DEM) data to a 30 m resolution for simulations. This information determined the distribution of slope gradients within each VIC grid cell. This study applied VIC-WEPP over the 1979-2010 period and compared an ensemble of future climate simulations for the period of 2041-2070. For future scenarios, we only considered meteorological impacts on post-fire erosion and did not incorporate changes in future fire occurrence or severity. We ran scenarios for a variety of land cover and soil parameter sets, particularly those that relate to pre and post-fire characteristics, such as vegetative cover, interrill and rill erodibility factors, and saturated hydraulic conductivity. Evaluation of runoff erosion at experimental sites, observed by the U.S. Forest Service, involved using Disturbed WEPP which showed reasonable first post-fire year annual erosion predictions. We evaluated VIC-WEPP by comparing sediment observations downstream of the SRB with simulated yields for both pre and post-fire conditions. Generation of maps showing erosion over the SRB for each of the scenarios show specific areas within the SRB to be high, moderate, or low runoff-induced post-fire erosion regions. Our methodology will enable forest managers in the region to incorporate the impacts of changes in meteorological events on runoff erosion into their strategic management plans.

Sliding Mode Control of the X-33 with an Engine Failure

NASA Technical Reports Server (NTRS)

Shtessel, Yuri B.; Hall, Charles E.

2000-01-01

Ascent flight control of the X-3 is performed using two XRS-2200 linear aerospike engines. in addition to aerosurfaces. The baseline control algorithms are PID with gain scheduling. Flight control using an innovative method. Sliding Mode Control. is presented for nominal and engine failed modes of flight. An easy to implement, robust controller. requiring no reconfiguration or gain scheduling is demonstrated through high fidelity flight simulations. The proposed sliding mode controller utilizes a two-loop structure and provides robust. de-coupled tracking of both orientation angle command profiles and angular rate command profiles in the presence of engine failure, bounded external disturbances (wind gusts) and uncertain matrix of inertia. Sliding mode control causes the angular rate and orientation angle tracking error dynamics to be constrained to linear, de-coupled, homogeneous, and vector valued differential equations with desired eigenvalues. Conditions that restrict engine failures to robustness domain of the sliding mode controller are derived. Overall stability of a two-loop flight control system is assessed. Simulation results show that the designed controller provides robust, accurate, de-coupled tracking of the orientation angle command profiles in the presence of external disturbances and vehicle inertia uncertainties, as well as the single engine failed case. The designed robust controller will significantly reduce the time and cost associated with flying new trajectory profiles or orbits, with new payloads, and with modified vehicles

Compassionate communities: design and preliminary results of the experience of Vic (Barcelona, Spain) caring city.

PubMed

Gómez-Batiste, Xavier; Mateu, Silvia; Serra-Jofre, Susagna; Molas, Magda; Mir-Roca, Sarah; Amblàs, Jordi; Costa, Xavier; Lasmarías, Cristina; Serrarols, Marta; Solà-Serrabou, Alvar; Calle, Candela; Kellehear, Allan

2018-04-01

A program of Compassionate City or Community (CC) has been designed and developed in the City of Vic (43,964 habitants, Barcelona, Spain), based on The Compassionate City Charter and other public health literature and experiments, with the joint leadership of the City Council and the Chair of Palliative Care at the University of Vic, and as an expansion of a comprehensive and integrated system of palliative care. The program started with an assessment of needs of the city as identified by 48 social organizations with a foundational workshop and a semi-structured survey. After this assessment, the mission, vision, values and aims were agreed. The main aims consisted in promoting changes in social and cultural attitudes toward the end of life (EoL) and providing integrated care for people with advanced chronic conditions and social needs such as loneliness, poverty, low access to services at home, or conflict. The selected slogan was "Living with meaning, dignity, and support the end of life". The program for the first year has included 19 activities (cultural, training, informative, and mixed) and followed by 1,260 attendants, and the training activities were followed by 147 people. Local and regional sponsors are funding the initiative. After a year, a quantitative and qualitative evaluation was performed, showing high participation and satisfaction of the attendants and organizations. In the second year, the care for particular vulnerable people defined as targets (EoL and social factors described before) will start with volunteers with more organizations to join the project. The key identified factors for the initial success are: the strong joint leadership between social department of the Council and the University; clear aims and targets; high participation rates; the limited size of the geographical context; which allowed high participation and recognition; and the commitment to evaluate results.

The emergence of Zipf's law - Spontaneous encoding optimization by users of a command language

NASA Technical Reports Server (NTRS)

Ellis, S. R.; Hitchcock, R. J.

1986-01-01

The distribution of commands issued by experienced users of a computer operating system allowing command customization tends to conform to Zipf's law. This result documents the emergence of a statistical property of natural language as users master an artificial language. Analysis of Zipf's law by Mandelbrot and Cherry shows that its emergence in the computer interaction of experienced users may be interpreted as evidence that these users optimize their encoding of commands. Accordingly, the extent to which users of a command language exhibit Zipf's law can provide a metric of the naturalness and efficiency with which that language is used.

Cockpit displayed traffic information and distributed management in air traffic control

NASA Technical Reports Server (NTRS)

Kreifeldt, J. G.

1980-01-01

A graphical display of information (such as surrounding aircraft and navigation routes) in the cockpit on a cathode ray tube has been proposed for improving the safety, orderliness, and expeditiousness of the air traffic control system. An investigation of this method at NASA-Ames indicated a large reduction in controller verbal work load without increasing pilot verbal load; the visual work may be increased. The cockpit displayed traffic and navigation information system reduced response delays permitting pilots to maintain their spacing more closely and precisely than when depending entirely on controller-issued radar vectors and speed command.

SKYLAB (SL)-2 PRIME CREW - BLDG. 5 - JSC

NASA Image and Video Library

1973-03-20

S73-20713 (1 March 1973) --- Astronaut Charles Conrad Jr., commander of the first manned Skylab mission, wipes perspiration from his face following an exercise session on the bicycle ergometer during Skylab training at Johnson Space Center. Conrad is in the work and experiments compartment of the crew quarters of the Skylab Orbital Workshop (OWS) trainer at JSC. In addition to being the prime exercise for the crewmen, the ergometer is also used for the vector-cardiogram test and the metabolic activity experiment. The bicycle ergometer produces measured workloads for use in determining man's metabolic effectiveness. Photo credit: NASA

Veterinary Immunology Committee Toolkit Workshop 2010: progress and plans.

PubMed

Entrican, Gary; Lunney, Joan K

2012-07-15

The 3rd Veterinary Immunology Committee (VIC) Toolkit Workshop took place at the 9th International Veterinary Immunology Symposium (IVIS) in Tokyo, Japan on 18th August 2010. The Workshop built on previous Toolkit Workshops and covered various aspects of reagent development, commercialization and provision to the veterinary immunology research community. The emphasis was on open communication about current progress and future plans to avoid duplication of effort and to update priorities for reagent development. There were presentations on the major reagent development and networking projects such as the BBSRC/RERAD Immunological Toolbox (2004-2009), US Veterinary Immune Reagent Network (VIRN 2006-2010) that has just received renewal funding for 2010-2014, and EU Network for Animal Diseases Infectiology Research Facilities project (NADIR 2009-2013). There were also presentations and discussions on the use of reagents for assay development, particularly multiplexing, and how these new technologies will underpin basic research developments. Mechanisms for improved information exchange, especially though websites with VIC playing a central role, were identified. Copyright © 2011 Elsevier B.V. All rights reserved.

75 FR 51416 - Defense Federal Acquisition Regulation Supplement; Transportation (DFARS Case 2003-D028)

Federal Register 2010, 2011, 2012, 2013, 2014

2010-08-20

...) The Commander, Military Sealift Command (MSC), through the Contracts and Business Management... Contracts and Business Management Directorate, MSC; or (B) The Commander, through the SDDC global e-mailbox... management. Therefore, DoD has not performed a final regulatory flexibility analysis. No comments were...

Analysis of Water and Energy Budgets and Trends Using the NLDAS Monthly Data Sets

NASA Technical Reports Server (NTRS)

Vollmer, Bruce E.; Rui, Hualan; Mocko, David M.; Teng, William L.; Lei, Guang-Dih

2012-01-01

The North American Land Data Assimilation System (NLDAS) is a collaborative project between NASA GSFC, NOAA, Princeton University, and the University of Washington. NLDAS has created surface meteorological forcing data sets using the best-available observations and reanalyses. The forcing data sets are used to drive four separate land-surface models (LSMs), Mosaic, Noah, VIC, and SAC, to produce data sets of soil moisture, snow, runoff, and surface fluxes. NLDAS hourly data, accessible from the NASA GES DISC Hydrology Data Holdings Portal, http://disc.sci.gsfc.nasa.gov/hydrology/data-holdings, are widely used by various user communities in modeling, research, and applications, such as drought and flood monitoring, watershed and water quality management, and case studies of extreme events. More information is available at http://ldas.gsfc.nasa.gov/. To further facilitate analysis of water and energy budgets and trends, NLDAS monthly data sets have been recently released by NASA GES DISC.

Macroscale hydrologic modeling of ecologically relevant flow metrics

Treesearch

Seth J. Wenger; Charles H. Luce; Alan F. Hamlet; Daniel J. Isaak; Helen M. Neville

2010-01-01

Stream hydrology strongly affects the structure of aquatic communities. Changes to air temperature and precipitation driven by increased greenhouse gas concentrations are shifting timing and volume of streamflows potentially affecting these communities. The variable infiltration capacity (VIC) macroscale hydrologic model has been employed at regional scales to describe...

Book Analysis: Command and Control of Theater Forces: Adequacy,

DTIC Science & Technology

1988-04-01

COPN R OTIC 11 AIR COMMAND AND STAFF COLLEGE STUDENT REPORT BOOK ANALYSIS: COMMA1ND AND CONTROL OF THEATER FORCES: ADEQUACY1 MA~JOR JOHN J. WRIGHT 88...brIc rNT- PA-- DTIC TAS L DIstrbA(-c & %W1.~b~ ~ Vii D~ , _ _ _ ABOUT THE AUTHOR The author is currently a student at the Air Command and Staff...College, Maxwell AFB AL. A 1973 ROTC graduate from Allegheny College, he attended undergraduate pilot training at Reese AFB TX. From 1975-1980, he was a

jCompoundMapper: An open source Java library and command-line tool for chemical fingerprints

PubMed Central

2011-01-01

Background The decomposition of a chemical graph is a convenient approach to encode information of the corresponding organic compound. While several commercial toolkits exist to encode molecules as so-called fingerprints, only a few open source implementations are available. The aim of this work is to introduce a library for exactly defined molecular decompositions, with a strong focus on the application of these features in machine learning and data mining. It provides several options such as search depth, distance cut-offs, atom- and pharmacophore typing. Furthermore, it provides the functionality to combine, to compare, or to export the fingerprints into several formats. Results We provide a Java 1.6 library for the decomposition of chemical graphs based on the open source Chemistry Development Kit toolkit. We reimplemented popular fingerprinting algorithms such as depth-first search fingerprints, extended connectivity fingerprints, autocorrelation fingerprints (e.g. CATS2D), radial fingerprints (e.g. Molprint2D), geometrical Molprint, atom pairs, and pharmacophore fingerprints. We also implemented custom fingerprints such as the all-shortest path fingerprint that only includes the subset of shortest paths from the full set of paths of the depth-first search fingerprint. As an application of jCompoundMapper, we provide a command-line executable binary. We measured the conversion speed and number of features for each encoding and described the composition of the features in detail. The quality of the encodings was tested using the default parametrizations in combination with a support vector machine on the Sutherland QSAR data sets. Additionally, we benchmarked the fingerprint encodings on the large-scale Ames toxicity benchmark using a large-scale linear support vector machine. The results were promising and could often compete with literature results. On the large Ames benchmark, for example, we obtained an AUC ROC performance of 0.87 with a reimplementation of the extended connectivity fingerprint. This result is comparable to the performance achieved by a non-linear support vector machine using state-of-the-art descriptors. On the Sutherland QSAR data set, the best fingerprint encodings showed a comparable or better performance on 5 of the 8 benchmarks when compared against the results of the best descriptors published in the paper of Sutherland et al. Conclusions jCompoundMapper is a library for chemical graph fingerprints with several tweaking possibilities and exporting options for open source data mining toolkits. The quality of the data mining results, the conversion speed, the LPGL software license, the command-line interface, and the exporters should be useful for many applications in cheminformatics like benchmarks against literature methods, comparison of data mining algorithms, similarity searching, and similarity-based data mining. PMID:21219648

U. S. Naval Forces, Vietnam Monthly Historical Summary for June 1968

DTIC Science & Technology

1968-07-04

eneu" fire in the sane area. This time the Viet Cong achieved devastating results. PBR 750 had pursued and captured an eneM sampan _ _ that had evaded...crossing the Saigon River., but, eaierged vic;.orious with a total of 121 enem dead and 7 captured in thos* twD days of figbting. Four Yarines were

THE FUTURE OF THE EUROPEAN AIR TRANSPORT COMMAND: AN ANALYSIS OF CAPABILITY ENHANCEMENTS FROM THE ITALIAN AIR FORCE AND AIR MOBILITY COMMAND

DTIC Science & Technology

2016-02-15

25 Bibliography Bowie, Christopher, Fred Frostic, Kevin Lewis, John Lunch, David Ochmanek, and Philip Proppe. The New Calculus : Analyzing...a critical analysis. Carlisle, Pennsylvania: US Army War College, class 2012. Stewart , Rory. The Place in Between. Orlando, FL: Harcourt Books

Time-based self-spacing techniques using cockpit display of traffic information during approach to landing in a terminal area vectoring environment

NASA Technical Reports Server (NTRS)

Williams, D. H.

1983-01-01

A simulation study was undertaken to evaluate two time-based self-spacing techniques for in-trail following during terminal area approach. An electronic traffic display was provided in the weather radarscope location. The displayed self-spacing cues allowed the simulated aircraft to follow and to maintain spacing on another aircraft which was being vectored by air traffic control (ATC) for landing in a high-density terminal area. Separation performance data indicate the information provided on the traffic display was adequate for the test subjects to accurately follow the approach path of another aircraft without the assistance of ATC. The time-based technique with a constant-delay spacing criterion produced the most satisfactory spacing performance. Pilot comments indicate the workload associated with the self-separation task was very high and that additional spacing command information and/or aircraft autopilot functions would be desirable for operational implementational of the self-spacing task.

Design and Analysis of Coordinated Bank-to-Turn (CBTT) Autopilots for Bank-to-Turn (BTT) Missiles.

DTIC Science & Technology

1983-12-01

with the acceleration command shown in Figures 4.3 it was necessary to modify the antigravity command as follows to S..assure an anti-gravity bias of...and the kinematic cross-coupling of -B.P into a. Also the antigravity command coso cose is inserted into nz. This model is shown in Figure 4.1. The

Human-computer interface for the study of information fusion concepts in situation analysis and command decision support systems

NASA Astrophysics Data System (ADS)

Roy, Jean; Breton, Richard; Paradis, Stephane

2001-08-01

Situation Awareness (SAW) is essential for commanders to conduct decision-making (DM) activities. Situation Analysis (SA) is defined as a process, the examination of a situation, its elements, and their relations, to provide and maintain a product, i.e., a state of SAW for the decision maker. Operational trends in warfare put the situation analysis process under pressure. This emphasizes the need for a real-time computer-based Situation analysis Support System (SASS) to aid commanders in achieving the appropriate situation awareness, thereby supporting their response to actual or anticipated threats. Data fusion is clearly a key enabler for SA and a SASS. Since data fusion is used for SA in support of dynamic human decision-making, the exploration of the SA concepts and the design of data fusion techniques must take into account human factor aspects in order to ensure a cognitive fit of the fusion system with the decision-maker. Indeed, the tight human factor aspects in order to ensure a cognitive fit of the fusion system with the decision-maker. Indeed, the tight integration of the human element with the SA technology is essential. Regarding these issues, this paper provides a description of CODSI (Command Decision Support Interface), and operational- like human machine interface prototype for investigations in computer-based SA and command decision support. With CODSI, one objective was to apply recent developments in SA theory and information display technology to the problem of enhancing SAW quality. It thus provides a capability to adequately convey tactical information to command decision makers. It also supports the study of human-computer interactions for SA, and methodologies for SAW measurement.

A north-south stationkeeping ion thruster system for ATS-F.

NASA Technical Reports Server (NTRS)

Worlock, R.; James, E.; Ramsey, W.; Trump, G.; Gant, G.; Jan, L.; Bartlett, R.

1972-01-01

An ion thruster system is being developed for the ATS-F satellite to demonstrate the application of ion thruster technology to the synchronous satellite north-south stationkeeping mission. The cesium bombardment ion thruster develops one millipound thrust at 2600 seconds specific impulse and provides thrust vectoring by accelerator electrode displacement. The propellant system is sized for two years operation at 25 percent duty cycle. Power conditioning circuitry is based on transistor inverters switching at 10 kHz. Thirteen command channels allow flexibility in operation; 12 telemetry channels provide information on system performance. Input power is less than 150 watts.

A natural command language for C/3/I applications

NASA Astrophysics Data System (ADS)

Mergler, J. P.

1980-03-01

The article discusses the development of a natural command language and a control and analysis console designed to simplify the task of the operator in field of Command, Control, Communications, and Intelligence. The console is based on a DEC LSI-11 microcomputer, supported by 16-K words of memory and a serial interface component. Discussion covers the language, which utilizes English and a natural syntax, and how it is integrated with the hardware. It is concluded that results have demonstrated the effectiveness of this natural command language.

The Gallant Stand: An Analysis of the Union Army of the Border’s Use of Mission Command at the Battle of the Little Blue, 21 October 1864

DTIC Science & Technology

2016-06-10

1864 A thesis presented to the Faculty of the U.S. Army Command and General Staff College in partial fulfillment of the requirements for...ORGANIZATION NAME(S) AND ADDRESS(ES) U.S. Army Command and General Staff College ATTN: ATZL-SWD-GD Fort Leavenworth, KS 66027-2301 8. PERFORMING...the student author and do not necessarily represent the views of the U.S. Army Command and General Staff College or any other governmental agency

A Computer-Based System Integrating Instruction and Information Retrieval: A Description of Some Methodological Considerations.

ERIC Educational Resources Information Center

Selig, Judith A.; And Others

This report, summarizing the activities of the Vision Information Center (VIC) in the field of computer-assisted instruction from December, 1966 to August, 1967, describes the methodology used to load a large body of information--a programed text on basic opthalmology--onto a computer for subsequent information retrieval and computer-assisted…

Benefit Analysis of the Automated Flow Control Function of the Air Traffic Control Systems Command Center

DOT National Transportation Integrated Search

1977-06-01

This report summarizes the findings of a benefit analysis study of the present and proposed Air Traffic Control Systems Command Center automation systems. The benefits analyzed were those associated with Fuel Advisory Departure and Quota Flow procedu...

An Analysis of Special Operations Command - South’s Distributive Command and Control Concept

DTIC Science & Technology

2007-12-01

Special Ops aviation unit traverses Bermuda Triangle en route to new home”, News Service Release Number 03082525 (August 2003), http://news.soc.mil...7, 2007). U.S. Army Special Operations Command. “Special Ops Aviation Unit Traverses Bermuda Triangle En Route to New Home.” News Service Release

HESS Opinions: The need for process-based evaluation of large-domain hyper-resolution models

NASA Astrophysics Data System (ADS)

Melsen, Lieke A.; Teuling, Adriaan J.; Torfs, Paul J. J. F.; Uijlenhoet, Remko; Mizukami, Naoki; Clark, Martyn P.

2016-03-01

A meta-analysis on 192 peer-reviewed articles reporting on applications of the variable infiltration capacity (VIC) model in a distributed way reveals that the spatial resolution at which the model is applied has increased over the years, while the calibration and validation time interval has remained unchanged. We argue that the calibration and validation time interval should keep pace with the increase in spatial resolution in order to resolve the processes that are relevant at the applied spatial resolution. We identified six time concepts in hydrological models, which all impact the model results and conclusions. Process-based model evaluation is particularly relevant when models are applied at hyper-resolution, where stakeholders expect credible results both at a high spatial and temporal resolution.

HESS Opinions: The need for process-based evaluation of large-domain hyper-resolution models

NASA Astrophysics Data System (ADS)

Melsen, L. A.; Teuling, A. J.; Torfs, P. J. J. F.; Uijlenhoet, R.; Mizukami, N.; Clark, M. P.

2015-12-01

A meta-analysis on 192 peer-reviewed articles reporting applications of the Variable Infiltration Capacity (VIC) model in a distributed way reveals that the spatial resolution at which the model is applied has increased over the years, while the calibration and validation time interval has remained unchanged. We argue that the calibration and validation time interval should keep pace with the increase in spatial resolution in order to resolve the processes that are relevant at the applied spatial resolution. We identified six time concepts in hydrological models, which all impact the model results and conclusions. Process-based model evaluation is particularly relevant when models are applied at hyper-resolution, where stakeholders expect credible results both at a high spatial and temporal resolution.

Autonomous Instrument Placement for Mars Exploration Rovers

NASA Technical Reports Server (NTRS)

Leger, P. Chris; Maimone, Mark

2009-01-01

Autonomous Instrument Placement (AutoPlace) is onboard software that enables a Mars Exploration Rover to act autonomously in using its manipulator to place scientific instruments on or near designated rock and soil targets. Prior to the development of AutoPlace, it was necessary for human operators on Earth to plan every motion of the manipulator arm in a time-consuming process that included downlinking of images from the rover, analysis of images and creation of commands, and uplinking of commands to the rover. AutoPlace incorporates image analysis and planning algorithms into the onboard rover software, eliminating the need for the downlink/uplink command cycle. Many of these algorithms are derived from the existing groundbased image analysis and planning algorithms, with modifications and augmentations for onboard use.

V/STOL Systems Research Aircraft: A Tool for Cockpit Integration

NASA Technical Reports Server (NTRS)

Stortz, Michael W.; ODonoghue, Dennis P.; Tiffany, Geary (Technical Monitor)

1995-01-01

The next generation ASTOVL aircraft will have a complicated propulsion System. The configuration choices include Direct Lift, Lift-Fan and Lift+Lift /Cruise but the aircraft must also have supersonic performance and low-observable characteristics. The propulsion system may have features such as flow blockers, vectoring nozzles and flow transfer schemes. The flight control system will necessarily fully integrate the aerodynamic surfaces and the propulsive elements. With a fully integrated, fly-by-wire flight/propulsion control system, the options for cockpit integration are interesting and varied. It is possible to decouple longitudinal and vertical responses allowing the pilot to close the loop on flight path and flight path acceleration directly. In the hover, the pilot can control the translational rate directly without having to stabilize the inner rate and attitude loops. The benefit of this approach, reduced workload and increased precision. has previously been demonstrated through several motion-based simulations. In order to prove the results in flight, the V/STOL System Research Aircraft (VSRA) was developed at the NASA Ames Research Center. The VSRA is the YAV-8B Prototype modified with a research flight control system using a series-parallel servo configuration in all the longitudinal degrees of freedom (including thrust and thrust vector angle) to provide an integrated flight and propulsion control system in a limited envelope. Development of the system has been completed and flight evaluations of the response types have been performed. In this paper we will discuss the development of the VSRA, the evolution of the flight path command and translational rate command response types and the Guest Pilot evaluations of the system. Pilot evaluation results will be used to draw conclusions regarding the suitability of the system to satisfy V/STOL requirements.

V/STOL systems research aircraft: A tool for cockpit integration

NASA Technical Reports Server (NTRS)

Stortz, Michael W.; ODonoghue, Dennis P.

1995-01-01

The next generation ASTOVL aircraft will have a complicated propulsion system. The configuration choices include Direct Lift, Lift-Fan and Lift + Lift/Cruise but the aircraft must also have supersonic performance and low-observable characteristics. The propulsion system may have features such as flow blockers, vectoring nozzles and flow transfer schemes. The flight control system will necessarily fully integrate the aerodynamic surfaces and the propulsive elements. With a fully integrated, fly-by-wire flight/propulsion control system, the options for cockpit integration are interesting and varied. It is possible to de-couple longitudinal and vertical responses allowing the pilot to close the loop on flightpath and flightpath acceleration directly. In the hover, the pilot can control the translational rate directly without having to stabilize the inner rate and attitude loops. The benefit of this approach, reduced workload and increased precision, has previously been demonstrated through several motion-based simulations. In order to prove the results in flight, the V/STOL System Research Aircraft (VSRA) was developed at the NASA Ames Research Center. The VSRA is the YAV-8B Prototype modified with a research flight control system using a series-parallel servo configuration in all the longitudinal degrees of freedom (including thrust and thrust vector angle) to provide an integrated flight and propulsion control system in a limited envelope. Development of the system has been completed and flight evaluations of the response types have been performed. In this paper we will discuss the development of the VSRA, the evolution of the flightpath command and translational rate command response types and the Guest Pilot evaluations of the system. Pilot evaluation results are used to draw conclusions regarding the suitability of the system to satisfy V/STOL requirements.

Comparison between a classical command law and a new advanced recovery command law in a MCB-ARS boost

NASA Astrophysics Data System (ADS)

Petit, Pierre; Saint-Eve, Frédéric; Sawicki, Jean-Paul; Aillerie, Michel

2017-02-01

This paper focuses on an original performed command on DC-DC boosts developed for applications in the LMOPS lab for the photovoltaic energy conversion and more specifically the Photovoltaic panels connected to HVDC smart grids. This boost, commonly named MCB-ARS (Magnetically Coupled Boost with Active Recovery Switch) presents great advantages concerning the simplicity of the command on the single constitutive switch, the global efficiency and the voltage conversion ratio. A fine analysis of the losses all over the entire converter shows that losses are not distributed uniformly in the constituting components. So a previous modification described in a previous paper consisting in the conducting assistance on the power flowing intermediate diode, performed advantageously the global efficiency. The present analysis takes into account the fact that the new configuration obtained after this important improvement looks like a classical half-bridge push-pull stage and may be controlled by a twice complementary command. In that way, a comparison has been done between a natural commutation recovery diode and an assisted switch commutation driven in a push-pull mode. As attempted, the switching command laws in charge to assume the energy transfer has been compared to the classical previous system described in anterior papers, and we demonstrate in this publication that a commutation based on a push-pull command mode within the two switches of the MCB-ARS converter is possible and increases the power transfer.

Text analysis devices, articles of manufacture, and text analysis methods

DOEpatents

Turner, Alan E; Hetzler, Elizabeth G; Nakamura, Grant C

2015-03-31

Text analysis devices, articles of manufacture, and text analysis methods are described according to some aspects. In one aspect, a text analysis device includes a display configured to depict visible images, and processing circuitry coupled with the display and wherein the processing circuitry is configured to access a first vector of a text item and which comprises a plurality of components, to access a second vector of the text item and which comprises a plurality of components, to weight the components of the first vector providing a plurality of weighted values, to weight the components of the second vector providing a plurality of weighted values, and to combine the weighted values of the first vector with the weighted values of the second vector to provide a third vector.

Introduction to the computational structural mechanics testbed

NASA Technical Reports Server (NTRS)

Lotts, C. G.; Greene, W. H.; Mccleary, S. L.; Knight, N. F., Jr.; Paulson, S. S.; Gillian, R. E.

1987-01-01

The Computational Structural Mechanics (CSM) testbed software system based on the SPAR finite element code and the NICE system is described. This software is denoted NICE/SPAR. NICE was developed at Lockheed Palo Alto Research Laboratory and contains data management utilities, a command language interpreter, and a command language definition for integrating engineering computational modules. SPAR is a system of programs used for finite element structural analysis developed for NASA by Lockheed and Engineering Information Systems, Inc. It includes many complementary structural analysis, thermal analysis, utility functions which communicate through a common database. The work on NICE/SPAR was motivated by requirements for a highly modular and flexible structural analysis system to use as a tool in carrying out research in computational methods and exploring computer hardware. Analysis examples are presented which demonstrate the benefits gained from a combination of the NICE command language with a SPAR computational modules.

The computational structural mechanics testbed procedures manual

NASA Technical Reports Server (NTRS)

Stewart, Caroline B. (Compiler)

1991-01-01

The purpose of this manual is to document the standard high level command language procedures of the Computational Structural Mechanics (CSM) Testbed software system. A description of each procedure including its function, commands, data interface, and use is presented. This manual is designed to assist users in defining and using command procedures to perform structural analysis in the CSM Testbed User's Manual and the CSM Testbed Data Library Description.

Dissociation of eye and head components of gaze shifts by stimulation of the omnipause neuron region.

PubMed

Gandhi, Neeraj J; Sparks, David L

2007-07-01

Natural movements often include actions integrated across multiple effectors. Coordinated eye-head movements are driven by a command to shift the line of sight by a desired displacement vector. Yet because extraocular and neck motoneurons are separate entities, the gaze shift command must be separated into independent signals for eye and head movement control. We report that this separation occurs, at least partially, at or before the level of pontine omnipause neurons (OPNs). Stimulation of the OPNs prior to and during gaze shifts temporally decoupled the eye and head components by inhibiting gaze and eye saccades. In contrast, head movements were consistently initiated before gaze onset, and ongoing head movements continued along their trajectories, albeit with some characteristic modulations. After stimulation offset, a gaze shift composed of an eye saccade, and a reaccelerated head movement was produced to preserve gaze accuracy. We conclude that signals subject to OPN inhibition produce the eye-movement component of a coordinated eye-head gaze shift and are not the only signals involved in the generation of the head component of the gaze shift.

Peer Influence, Information Quality and Predictive Power of Stock Microblogs

ERIC Educational Resources Information Center

Oh, Chong Keat

2013-01-01

Due to the popularity of Web 2.0 and Social Media in the last decade, the percolation of user generated content (UGC) has rapidly increased. In the financial realm, this results in the emergence of virtual investing communities (VIC) to the investing public. There is an on-going debate among scholars and practitioners on whether such UGC contain…

Embedded CLIPS for SDI BM/C3 simulation and analysis

NASA Technical Reports Server (NTRS)

Gossage, Brett; Nanney, Van

1990-01-01

Nichols Research Corporation is developing the BM/C3 Requirements Analysis Tool (BRAT) for the U.S. Army Strategic Defense Command. BRAT uses embedded CLIPS/Ada to model the decision making processes used by the human commander of a defense system. Embedding CLlPS/Ada in BRAT allows the user to explore the role of the human in Command and Control (C2) and the use of expert systems for automated C2. BRAT models assert facts about the current state of the system, the simulated scenario, and threat information into CLIPS/Ada. A user-defined rule set describes the decision criteria for the commander. We have extended CLIPS/Ada with user-defined functions that allow the firing of a rule to invoke a system action such as weapons release or a change in strategy. The use of embedded CLIPS/Ada will provide a powerful modeling tool for our customer at minimal cost.

Closing Time?

ERIC Educational Resources Information Center

Muir, Rick

2012-01-01

There are few institutions so central to Britain's culture and way of life as the local public house. Try to imagine Coronation Street without The Rover's Return, Emmerdale without The Woolpack or EastEnders without The Queen Vic. Outside the home the pub is the most popular place for British people of all ages and classes to relax and socialise.…

Slide Set: Reproducible image analysis and batch processing with ImageJ.

PubMed

Nanes, Benjamin A

2015-11-01

Most imaging studies in the biological sciences rely on analyses that are relatively simple. However, manual repetition of analysis tasks across multiple regions in many images can complicate even the simplest analysis, making record keeping difficult, increasing the potential for error, and limiting reproducibility. While fully automated solutions are necessary for very large data sets, they are sometimes impractical for the small- and medium-sized data sets common in biology. Here we present the Slide Set plugin for ImageJ, which provides a framework for reproducible image analysis and batch processing. Slide Set organizes data into tables, associating image files with regions of interest and other relevant information. Analysis commands are automatically repeated over each image in the data set, and multiple commands can be chained together for more complex analysis tasks. All analysis parameters are saved, ensuring transparency and reproducibility. Slide Set includes a variety of built-in analysis commands and can be easily extended to automate other ImageJ plugins, reducing the manual repetition of image analysis without the set-up effort or programming expertise required for a fully automated solution.

A Gap Analysis of Life Cycle Management Commands and Best Purchasing and Supply Management Organizations

DTIC Science & Technology

2013-01-01

of the Army’s Life Cycle Management Commands (LCMCs)—those for Aviation and Missiles (AMCOM), Communications - Electronics (CECOM), and Tank-automotive...took time from their busy schedules to participate in our interviews. We would like to thank Lieutenant Colonel John Coombs for helping us track down...Army Communications -Electronics Life Cycle Management Command CPFR collaborative planning, forecasting, and replenishment DCMA Defense Contract

Joint Command Support Through Workspace Analysis, Design and Optimization (Soutien du Commandement Interarmees au Moyen de L’Analyse, de la Conception et de L’Optimisation de L’Espace de Travail)

DTIC Science & Technology

2009-10-01

WACC ); and • Joint Task Force (Games) Joint Operations Centre (GJOC). In May 2008, DRDC Toronto initiated two studies to support the workspace...Voice-over-IP WACC Whistler Area Command Centre DRDC Toronto TR 2009-100 39 Distribution list Document No.: DRDC CR 2009-028 LIST

Total Army Analysis Supporting Maximization of National Resources

DTIC Science & Technology

2013-03-01

Robert M. Mundell Department of Command Leadership and Management 8. PERFORMING ORGANIZATION REPORT NUMBER 9. SPONSORING/MONITORING AGENCY...Colonel Robert M. Mundell Department of Command Leadership and Management Project Adviser This manuscript is submitted in partial fulfillment

Real-time PCR for simultaneous detection and genotyping of bovine viral diarrhea virus.

PubMed

Letellier, C; Kerkhofs, P

2003-12-01

Since two genotypes of bovine viral diarrhea viruses (BVDV) occur in Belgian herds, their differentiation is important for disease surveillance. A quantitative real-time PCR assay was developed to detect and classify bovine viral diarrhea viruses in genotype I and II. A pair of primers specific for highly conserved regions of the 5'UTR and two TaqMan probes were designed. The FAM and VIC-labeled probe sequences differed by three nucleotides, allowing the differentiation between genotype I and II. The assay detectability of genotype I and II real-time PCR assay was 1000 and 100 copies, respectively. Highly reproducible data were obtained as the coefficients of variation of threshold cycle values in inter-runs were less than 2.2%. The correct classification of genotype I and II viruses was assessed by using reference strains and characterized field isolates of both genotypes. The application to clinical diagnosis was evaluated on pooled blood samples by post run measurement of the FAM- and VIC-associated fluorescence. The 100% agreement with the conventional RT-PCR method confirmed that this new technique could be used for routine detection of persistently infected immunotolerant animals.

VHF command system study. [spectral analysis of GSFC VHF-PSK and VHF-FSK Command Systems

NASA Technical Reports Server (NTRS)

Gee, T. H.; Geist, J. M.

1973-01-01

Solutions are provided to specific problems arising in the GSFC VHF-PSK and VHF-FSK Command Systems in support of establishment and maintenance of Data Systems Standards. Signal structures which incorporate transmission on the uplink of a clock along with the PSK or FSK data are considered. Strategies are developed for allocating power between the clock and data, and spectral analyses are performed. Bit error probability and other probabilities pertinent to correct transmission of command messages are calculated. Biphase PCM/PM and PCM/FM are considered as candidate modulation techniques on the telemetry downlink, with application to command verification. Comparative performance of PCM/PM and PSK systems is given special attention, including implementation considerations. Gain in bit error performance due to coding is also considered.

40 CFR 228.15 - Dumping sites designated on a final basis.

Code of Federal Regulations, 2011 CFR

2011-07-01

... designation to establish different or additional standards. The EPA will act on any such petition within 120...) Disposal not subject to the restrictions in paragraphs (b)(4)(vi)(C) through (G) or (b)(4)(vi)(I) of this... prior to the completion of the DMMP and completed within two years after the completion of the DMMP. (J...

Plasma Theory and Simulation.

DTIC Science & Technology

1978-07-01

l l) A paper t i t led “Part icle-Fluid Hybrid Codes Applied to Beam- Plasma , Ring -Plasma Instabi l i ties ” was presented at Monterey (see Section V...ic le-Fluid Hybr id Codes Applied to Beam- Plasma , Ring -Plasma Ins tab i l i t ies”. (2) A. Peiravi and C. K. Birdsall , “Self-Heating of id Therma l

Colorado River basin sensitivity to disturbance impacts

NASA Astrophysics Data System (ADS)

Bennett, K. E.; Urrego-Blanco, J. R.; Jonko, A. K.; Vano, J. A.; Newman, A. J.; Bohn, T. J.; Middleton, R. S.

2017-12-01

The Colorado River basin is an important river for the food-energy-water nexus in the United States and is projected to change under future scenarios of increased CO2emissions and warming. Streamflow estimates to consider climate impacts occurring as a result of this warming are often provided using modeling tools which rely on uncertain inputs—to fully understand impacts on streamflow sensitivity analysis can help determine how models respond under changing disturbances such as climate and vegetation. In this study, we conduct a global sensitivity analysis with a space-filling Latin Hypercube sampling of the model parameter space and statistical emulation of the Variable Infiltration Capacity (VIC) hydrologic model to relate changes in runoff, evapotranspiration, snow water equivalent and soil moisture to model parameters in VIC. Additionally, we examine sensitivities of basin-wide model simulations using an approach that incorporates changes in temperature, precipitation and vegetation to consider impact responses for snow-dominated headwater catchments, low elevation arid basins, and for the upper and lower river basins. We find that for the Colorado River basin, snow-dominated regions are more sensitive to uncertainties. New parameter sensitivities identified include runoff/evapotranspiration sensitivity to albedo, while changes in snow water equivalent are sensitive to canopy fraction and Leaf Area Index (LAI). Basin-wide streamflow sensitivities to precipitation, temperature and vegetation are variable seasonally and also between sub-basins; with the largest sensitivities for smaller, snow-driven headwater systems where forests are dense. For a major headwater basin, a 1ºC of warming equaled a 30% loss of forest cover, while a 10% precipitation loss equaled a 90% forest cover decline. Scenarios utilizing multiple disturbances led to unexpected results where changes could either magnify or diminish extremes, such as low and peak flows and streamflow timing, dependent on the strength and direction of the forcing. These results indicate the importance of understanding model sensitivities under disturbance impacts to manage these shifts; plan for future water resource changes and determine how the impacts will affect the sustainability and adaptability of food-energy-water systems.

Analysis of space telescope data collection system

NASA Technical Reports Server (NTRS)

Ingels, F. M.; Schoggen, W. O.

1982-01-01

An analysis of the expected performance for the Multiple Access (MA) system is provided. The analysis covers the expected bit error rate performance, the effects of synchronization loss, the problem of self-interference, and the problem of phase ambiguity. The problem of false acceptance of a command word due to data inversion is discussed. A mathematical determination of the probability of accepting an erroneous command word due to a data inversion is presented. The problem is examined for three cases: (1) a data inversion only, (2) a data inversion and a random error within the same command word, and a block (up to 256 48-bit words) containing both a data inversion and a random error.

Teaching Bibliometric Analysis and MS/DOS Commands.

ERIC Educational Resources Information Center

Dou, Henri; And Others

1988-01-01

Outlines the steps involved in bibliometric studies, and demonstrates the ability to execute simple studies on microcomputers by downloading files using only the capability of MS/DOS. Detailed illustrations of the MS/DOS commands used are provided. (eight references) (CLB)

Organizational Analysis of the United States Army Contracting Command-Kuwait

DTIC Science & Technology

2008-09-01

incongruent, which may have contributed to documented organizational dysfunctions; 2) The command should initiate meaningful morale building events into...the command’s schedule and encourage use of existing morale , welfare, and recreation activities; and 3) Recommend the command establish clear and...should initiate meaningful morale building events into the command’s schedule and encourage use of existing morale , welfare, and recreation

Rule-Based Expert Systems in the Command Estimate: An Operational Perspective

DTIC Science & Technology

1990-06-01

control measures. 5. Prepare COA statement(s) and sketch(es). The key inputs for developing courses of action are the DFD process of IPB, data stores...mission, or a change of information provides new direction to this process for that particular operation." Formal scientific analysis of the command...30 5. Delivery of outside news . This feature contributes to the commanders insatiable need for current information. Artificial intelligence ana rule

Primer for the Transportable Applications Executive

NASA Technical Reports Server (NTRS)

Carlson, P. A.; Emmanuelli, C. A.; Harris, E. L.; Perkins, D. C.

1984-01-01

The Transportable Applications Executive (TAE), an interactive multipurpose executive that provides commonly required functions for scientific analysis systems, is discussed. The concept of an executive is discussed and the various components of TAE are presented. These include on-line help information, the use of menus or commands to access analysis programs, and TAE command procedures.

Titan 3E/Centaur D-1T Systems Summary

NASA Technical Reports Server (NTRS)

1973-01-01

A systems and operational summary of the Titan 3E/Centaur D-1T program is presented which describes vehicle assembly facilities, launch facilities, and management responsibilities, and also provides detailed information on the following separate systems: (1) mechanical systems, including structural components, insulation, propulsion units, reaction control, thrust vector control, hydraulic systems, and pneumatic equipment; (2) astrionics systems, such as instrumentation and telemetry, navigation and guidance, C-Band tracking system, and range safety command system; (3) digital computer unit software; (4) flight control systems; (5) electrical/electronic systems; and (6) ground support equipment, including checkout equipment.

Land Ahoy! Understanding Submarine Command and Control During the Completion of Inshore Operations.

PubMed

Roberts, Aaron P J; Stanton, Neville A; Fay, Daniel

2017-12-01

The aim of this study was to use multiple command teams to provide empirical evidence for understanding communication flow, information pertinence, and tasks undertaken in a submarine control room when completing higher- and lower-demand inshore operation (INSO) scenarios. The focus of submarine operations has changed, and submarines are increasingly required to operate in costal littoral zones. However, submarine command team performance during INSO is not well understood, particularly from a sociotechnical systems perspective. A submarine control-room simulator was built. The creation of networked workstations allowed a team of nine operators to perform tasks completed by submarine command teams during INSO. The Event Analysis of Systematic Teamwork method was used to model the social, task, and information networks and to describe command team performance. Ten teams were recruited for the study, affording statistical comparisons of how command-team roles and level of demand affected performance. Results indicated that the submarine command-team members are required to rapidly integrate sonar and visual data as the periscope is used, periodically, in a "duck-and-run" fashion, to maintain covertness. The fusion of such information is primarily completed by the operations officer (OPSO), with this operator experiencing significantly greater demand than any other operator. The OPSO was a bottleneck in the command team when completing INSO, experiencing similar load in both scenarios, suggesting that the command team may benefit from data synthesis tasks being more evenly distributed within the command team. The work can inform future control-room design and command-team ways of working by identifying bottlenecks in terms of information and task flow between operators.

VAPEPS user's reference manual, version 5.0

NASA Technical Reports Server (NTRS)

Park, D. M.

1988-01-01

This is the reference manual for the VibroAcoustic Payload Environment Prediction System (VAPEPS). The system consists of a computer program and a vibroacoustic database. The purpose of the system is to collect measurements of vibroacoustic data taken from flight events and ground tests, and to retrieve this data and provide a means of using the data to predict future payload environments. This manual describes the operating language of the program. Topics covered include database commands, Statistical Energy Analysis (SEA) prediction commands, stress prediction command, and general computational commands.

High-Resolution Assimilation of GRACE Terrestrial Water Storage Observations to Represent Local-Scale Water Table Depths

NASA Astrophysics Data System (ADS)

Stampoulis, D.; Reager, J. T., II; David, C. H.; Famiglietti, J. S.; Andreadis, K.

2017-12-01

Despite the numerous advances in hydrologic modeling and improvements in Land Surface Models, an accurate representation of the water table depth (WTD) still does not exist. Data assimilation of observations of the joint NASA and DLR mission, Gravity Recovery and Climate Experiment (GRACE) leads to statistically significant improvements in the accuracy of hydrologic models, ultimately resulting in more reliable estimates of water storage. However, the usually shallow groundwater compartment of the models presents a problem with GRACE assimilation techniques, as these satellite observations account for much deeper aquifers. To improve the accuracy of groundwater estimates and allow the representation of the WTD at fine spatial scales we implemented a novel approach that enables a large-scale data integration system to assimilate GRACE data. This was achieved by augmenting the Variable Infiltration Capacity (VIC) hydrologic model, which is the core component of the Regional Hydrologic Extremes Assessment System (RHEAS), a high-resolution modeling framework developed at the Jet Propulsion Laboratory (JPL) for hydrologic modeling and data assimilation. The model has insufficient subsurface characterization and therefore, to reproduce groundwater variability not only in shallow depths but also in deep aquifers, as well as to allow GRACE assimilation, a fourth soil layer of varying depth ( 1000 meters) was added in VIC as the bottom layer. To initialize a water table in the model we used gridded global WTD data at 1 km resolution which were spatially aggregated to match the model's resolution. Simulations were then performed to test the augmented model's ability to capture seasonal and inter-annual trends of groundwater. The 4-layer version of VIC was run with and without assimilating GRACE Total Water Storage anomalies (TWSA) over the Central Valley in California. This is the first-ever assimilation of GRACE TWSA for the determination of realistic water table depths, at fine scales that are required for local water management. In addition, Open Loop and GRACE-assimilation simulations of water table depth were compared to in-situ data over the state of California, derived from observation wells operated/maintained by the U.S. Geological Service.

VISA--Vector Integration Site Analysis server: a web-based server to rapidly identify retroviral integration sites from next-generation sequencing.

PubMed

Hocum, Jonah D; Battrell, Logan R; Maynard, Ryan; Adair, Jennifer E; Beard, Brian C; Rawlings, David J; Kiem, Hans-Peter; Miller, Daniel G; Trobridge, Grant D

2015-07-07

Analyzing the integration profile of retroviral vectors is a vital step in determining their potential genotoxic effects and developing safer vectors for therapeutic use. Identifying retroviral vector integration sites is also important for retroviral mutagenesis screens. We developed VISA, a vector integration site analysis server, to analyze next-generation sequencing data for retroviral vector integration sites. Sequence reads that contain a provirus are mapped to the human genome, sequence reads that cannot be localized to a unique location in the genome are filtered out, and then unique retroviral vector integration sites are determined based on the alignment scores of the remaining sequence reads. VISA offers a simple web interface to upload sequence files and results are returned in a concise tabular format to allow rapid analysis of retroviral vector integration sites.

Random vectors and spatial analysis by geostatistics for geotechnical applications

DOE Office of Scientific and Technical Information (OSTI.GOV)

Young, D.S.

1987-08-01

Geostatistics is extended to the spatial analysis of vector variables by defining the estimation variance and vector variogram in terms of the magnitude of difference vectors. Many random variables in geotechnology are in vectorial terms rather than scalars, and its structural analysis requires those sample variable interpolations to construct and characterize structural models. A better local estimator will result in greater quality of input models; geostatistics can provide such estimators; kriging estimators. The efficiency of geostatistics for vector variables is demonstrated in a case study of rock joint orientations in geological formations. The positive cross-validation encourages application of geostatistics tomore » spatial analysis of random vectors in geoscience as well as various geotechnical fields including optimum site characterization, rock mechanics for mining and civil structures, cavability analysis of block cavings, petroleum engineering, and hydrologic and hydraulic modelings.« less

Tier-scalable reconnaissance: the future in autonomous C4ISR systems has arrived: progress towards an outdoor testbed

NASA Astrophysics Data System (ADS)

Fink, Wolfgang; Brooks, Alexander J.-W.; Tarbell, Mark A.; Dohm, James M.

2017-05-01

Autonomous reconnaissance missions are called for in extreme environments, as well as in potentially hazardous (e.g., the theatre, disaster-stricken areas, etc.) or inaccessible operational areas (e.g., planetary surfaces, space). Such future missions will require increasing degrees of operational autonomy, especially when following up on transient events. Operational autonomy encompasses: (1) Automatic characterization of operational areas from different vantages (i.e., spaceborne, airborne, surface, subsurface); (2) automatic sensor deployment and data gathering; (3) automatic feature extraction including anomaly detection and region-of-interest identification; (4) automatic target prediction and prioritization; (5) and subsequent automatic (re-)deployment and navigation of robotic agents. This paper reports on progress towards several aspects of autonomous C4ISR systems, including: Caltech-patented and NASA award-winning multi-tiered mission paradigm, robotic platform development (air, ground, water-based), robotic behavior motifs as the building blocks for autonomous tele-commanding, and autonomous decision making based on a Caltech-patented framework comprising sensor-data-fusion (feature-vectors), anomaly detection (clustering and principal component analysis), and target prioritization (hypothetical probing).

Evaluation of the land surface water budget in NCEP/NCAR and NCEP/DOE reanalyses using an off-line hydrologic model

NASA Astrophysics Data System (ADS)

Maurer, Edwin P.; O'Donnell, Greg M.; Lettenmaier, Dennis P.; Roads, John O.

2001-08-01

The ability of the National Centers for Environmental Prediction (NCEP)/National Center for Atmospheric Research (NCAR) reanalysis (NRA1) and the follow-up NCEP/Department of Energy (DOE) reanalysis (NRA2), to reproduce the hydrologic budgets over the Mississippi River basin is evaluated using a macroscale hydrology model. This diagnosis is aided by a relatively unconstrained global climate simulation using the NCEP global spectral model, and a more highly constrained regional climate simulation using the NCEP regional spectral model, both employing the same land surface parameterization (LSP) as the reanalyses. The hydrology model is the variable infiltration capacity (VIC) model, which is forced by gridded observed precipitation and temperature. It reproduces observed streamflow, and by closure is constrained to balance other terms in the surface water and energy budgets. The VIC-simulated surface fluxes therefore provide a benchmark for evaluating the predictions from the reanalyses and the climate models. The comparisons, conducted for the 10-year period 1988-1997, show the well-known overestimation of summer precipitation in the southeastern Mississippi River basin, a consistent overestimation of evapotranspiration, and an underprediction of snow in NRA1. These biases are generally lower in NRA2, though a large overprediction of snow water equivalent exists. NRA1 is subject to errors in the surface water budget due to nudging of modeled soil moisture to an assumed climatology. The nudging and precipitation bias alone do not explain the consistent overprediction of evapotranspiration throughout the basin. Another source of error is the gravitational drainage term in the NCEP LSP, which produces the majority of the model's reported runoff. This may contribute to an overprediction of persistence of surface water anomalies in much of the basin. Residual evapotranspiration inferred from an atmospheric balance of NRA1, which is more directly related to observed atmospheric variables, matches the VIC prediction much more closely than the coupled models. However, the persistence of the residual evapotranspiration is much less than is predicted by the hydrological model or the climate models.

Using kinematic analysis of movement to predict the time occurrence of an evoked potential associated with a motor command.

PubMed

O'Reilly, Christian; Plamondon, Réjean; Landou, Mohamed K; Stemmer, Brigitte

2013-01-01

This article presents an exploratory study investigating the possibility of predicting the time occurrence of a motor event related potential (ERP) from a kinematic analysis of human movements. Although the response-locked motor potential may link the ERP components to the recorded response, to our knowledge no previous attempt has been made to predict a priori (i.e. before any contact with the electroencephalographic data) the time occurrence of an ERP component based only on the modeling of an overt response. The proposed analysis relies on the delta-lognormal modeling of velocity, as proposed by the kinematic theory of rapid human movement used in several studies of motor control. Although some methodological aspects of this technique still need to be fine-tuned, the initial results showed that the model-based kinematic analysis allowed the prediction of the time occurrence of a motor command ERP in most participants in the experiment. The average map of the motor command ERPs showed that this signal was stronger in electrodes close to the contra-lateral motor area (Fz, FCz, FC1, and FC3). These results seem to support the claims made by the kinematic theory that a motor command is emitted at time t(0), the time reference parameter of the model. This article proposes a new time marker directly associated with a cerebral event (i.e. the emission of a motor command) that can be used for the development of new data analysis methodologies and for the elaboration of new experimental protocols based on ERP. © 2012 Federation of European Neuroscience Societies and Blackwell Publishing Ltd.

Assessing the Use of Remote Sensing and a Crop Growth Model to Improve Modeled Streamflow in Central Asia

NASA Astrophysics Data System (ADS)

Richey, A. S.; Richey, J. E.; Tan, A.; Liu, M.; Adam, J. C.; Sokolov, V.

2015-12-01

Central Asia presents a perfect case study to understand the dynamic, and often conflicting, linkages between food, energy, and water in natural systems. The destruction of the Aral Sea is a well-known environmental disaster, largely driven by increased irrigation demand on the rivers that feed the endorheic sea. Continued reliance on these rivers, the Amu Darya and Syr Darya, often place available water resources at odds between hydropower demands upstream and irrigation requirements downstream. A combination of tools is required to understand these linkages and how they may change in the future as a function of climate change and population growth. In addition, the region is geopolitically complex as the former Soviet basin states develop management strategies to sustainably manage shared resources. This complexity increases the importance of relying upon publically available information sources and tools. Preliminary work has shown potential for the Variable Infiltration Capacity (VIC) model to recreate the natural water balance in the Amu Darya and Syr Darya basins by comparing results to total terrestrial water storage changes observed from NASA's Gravity Recovery and Climate Experiment (GRACE) satellite mission. Modeled streamflow is well correlated to observed streamflow at upstream gauges prior to the large-scale expansion of irrigation and hydropower. However, current modeled results are unable to capture the human influence of water use on downstream flow. This study examines the utility of a crop simulation model, CropSyst, to represent irrigation demand and GRACE to improve modeled streamflow estimates in the Amu Darya and Syr Darya basins. Specifically we determine crop water demand with CropSyst utilizing available data on irrigation schemes and cropping patterns. We determine how this demand can be met either by surface water, modeled by VIC with a reservoir operation scheme, and/or by groundwater derived from GRACE. Finally, we assess how the inclusion of CropSyst and groundwater to model and meet irrigation demand improves modeled streamflow from VIC throughout the basins. The results of this work are integrated into a decision support platform to assist the basin states in understanding water availability and the impact of management decisions on available resources.

The Impact of Stressors on Military Performance

DTIC Science & Technology

2013-12-01

Technology Organisation DSTO-GD-0780 ABSTRACT Military personnel are exposed to a range of stressors that potentially impact on their performance...and Technology Organisation 506 Lorimer Street Fishermans Bend VIC 3207 Telephone: 1300 362 332 Fax: 03 9626 7999 © Commonwealth of...automation will facilitate humans and technology seamlessly sharing control of tasks. UNCLASSIFIED DSTO-GD-0780 UNCLASSIFIED Contents 1

Frames of reference for gaze saccades evoked during stimulation of lateral intraparietal cortex.

PubMed

Constantin, A G; Wang, H; Martinez-Trujillo, J C; Crawford, J D

2007-08-01

Previous studies suggest that stimulation of lateral intraparietal cortex (LIP) evokes saccadic eye movements toward eye- or head-fixed goals, whereas most single-unit studies suggest that LIP uses an eye-fixed frame with eye-position modulations. The goal of our study was to determine the reference frame for gaze shifts evoked during LIP stimulation in head-unrestrained monkeys. Two macaques (M1 and M2) were implanted with recording chambers over the right intraparietal sulcus and with search coils for recording three-dimensional eye and head movements. The LIP region was microstimulated using pulse trains of 300 Hz, 100-150 microA, and 200 ms. Eighty-five putative LIP sites in M1 and 194 putative sites in M2 were used in our quantitative analysis throughout this study. Average amplitude of the stimulation-evoked gaze shifts was 8.67 degrees for M1 and 7.97 degrees for M2 with very small head movements. When these gaze-shift trajectories were rotated into three coordinate frames (eye, head, and body), gaze endpoint distribution for all sites was most convergent to a common point when plotted in eye coordinates. Across all sites, the eye-centered model provided a significantly better fit compared with the head, body, or fixed-vector models (where the latter model signifies no modulation of the gaze trajectory as a function of initial gaze position). Moreover, the probability of evoking a gaze shift from any one particular position was modulated by the current gaze direction (independent of saccade direction). These results provide causal evidence that the motor commands from LIP encode gaze command in eye-fixed coordinates but are also subtly modulated by initial gaze position.

Modeling Failure and Reliability in New-Generation Devices

DTIC Science & Technology

1990-07-15

them to point of per- manen da=age. An airaft enploying GaAs MMIC rIar DU] reccivr can expet to have the receiveis damaged by a Dects cko= appoach to...znergUy. usng tannielwg electron spxtrIDopy, an 8. Julie E. Lawr=,-e Vic~tcr A. J. van Lintk and Jamnes P. th = au usn ba bandC~ dopulses In Pw Of Raymcmd

Prior infection of pigs with a recent human H3N2 influenza virus confers minimal cross-protection against a European swine H3N2 virus.

PubMed

Qiu, Yu; van der Meulen, Karen; Van Reeth, Kristien

2013-11-01

H3N2 influenza viruses circulating in humans and European pigs originate from the pandemic A/Hong Kong/68 virus. Because of slower antigenic drift in swine, the antigenic divergence between swine and human viruses has been increasing. It remains unknown to what extent this results in a reduced cross-protection between recent human and swine H3N2 influenza viruses. We examined whether prior infection of pigs with an old [A/Victoria/3/75 (A/Vic/75)] or a more recent [A/Wisconsin/67/05 (A/Wis/05)] human H3N2 virus protected against a European swine H3N2 virus [sw/Gent/172/08 (sw/Gent/08)]. Genetic and antigenic relationships between sw/Gent/08 and a selection of human H3N2 viruses were also assessed. After challenge with sw/Gent/08, all challenge controls had high virus titers in the entire respiratory tract at 3 days post-challenge and nasal virus excretion for 5-6 days. Prior infection with sw/Gent/08 or A/Vic/75 offered complete virological protection against challenge. Pigs previously inoculated with A/Wis/05 showed similar virus titers in the respiratory tract as challenge controls, but the mean duration of nasal shedding was 1·3 days shorter. Unlike sw/Gent/08- and A/Vic/75-inoculated pigs, A/Wis/05-inoculated pigs lacked cross-reactive neutralizing antibodies against sw/Gent/08 before challenge, but they showed a more rapid antibody response to sw/Gent/08 than challenge controls after challenge. Cross-protection and serological responses correlated with genetic and antigenic differences. Infection immunity to a recent human H3N2 virus confers minimal cross-protection against a European swine H3N2 virus. We discuss our findings with regard to the recent zoonotic infections of humans in the United States with a swine-origin H3N2 variant virus. © 2013 John Wiley & Sons Ltd.

Procedure for Tooth Contact Analysis of a Face Gear Meshing With a Spur Gear Using Finite Element Analysis

NASA Technical Reports Server (NTRS)

Bibel, George; Lewicki, David G. (Technical Monitor)

2002-01-01

A procedure was developed to perform tooth contact analysis between a face gear meshing with a spur pinion using finite element analysis. The face gear surface points from a previous analysis were used to create a connected tooth solid model without gaps or overlaps. The face gear surface points were used to create a five tooth face gear Patran model (with rim) using Patran PCL commands. These commands were saved in a series of session files suitable for Patran input. A four tooth spur gear that meshes with the face gear was designed and constructed with Patran PCL commands. These commands were also saved in a session files suitable for Patran input. The orientation of the spur gear required for meshing with the face gear was determined. The required rotations and translations are described and built into the session file for the spur gear. The Abaqus commands for three-dimensional meshing were determined and verified for a simplified model containing one spur tooth and one face gear tooth. The boundary conditions, loads, and weak spring constraints were determined to make the simplified model work. The load steps and load increments to establish contact and obtain a realistic load was determined for the simplified two tooth model. Contact patterns give some insight into required mesh density. Building the two gears in two different local coordinate systems and rotating the local coordinate systems was verified as an easy way to roll the gearset through mesh. Due to limitation of swap space, disk space and time constraints of the summer period, the larger model was not completed.

Landslide Hazard from Coupled Inherent and Dynamic Probabilities

NASA Astrophysics Data System (ADS)

Strauch, R. L.; Istanbulluoglu, E.; Nudurupati, S. S.

2015-12-01

Landslide hazard research has typically been conducted independently from hydroclimate research. We sought to unify these two lines of research to provide regional scale landslide hazard information for risk assessments and resource management decision-making. Our approach couples an empirical inherent landslide probability, based on a frequency ratio analysis, with a numerical dynamic probability, generated by combining subsurface water recharge and surface runoff from the Variable Infiltration Capacity (VIC) macro-scale land surface hydrologic model with a finer resolution probabilistic slope stability model. Landslide hazard mapping is advanced by combining static and dynamic models of stability into a probabilistic measure of geohazard prediction in both space and time. This work will aid resource management decision-making in current and future landscape and climatic conditions. The approach is applied as a case study in North Cascade National Park Complex in northern Washington State.

QDENSITY—A Mathematica Quantum Computer simulation

NASA Astrophysics Data System (ADS)

Juliá-Díaz, Bruno; Burdis, Joseph M.; Tabakin, Frank

2006-06-01

This Mathematica 5.2 package is a simulation of a Quantum Computer. The program provides a modular, instructive approach for generating the basic elements that make up a quantum circuit. The main emphasis is on using the density matrix, although an approach using state vectors is also implemented in the package. The package commands are defined in Qdensity.m which contains the tools needed in quantum circuits, e.g., multiqubit kets, projectors, gates, etc. Selected examples of the basic commands are presented here and a tutorial notebook, Tutorial.nb is provided with the package (available on our website) that serves as a full guide to the package. Finally, application is made to a variety of relevant cases, including Teleportation, Quantum Fourier transform, Grover's search and Shor's algorithm, in separate notebooks: QFT.nb, Teleportation.nb, Grover.nb and Shor.nb where each algorithm is explained in detail. Finally, two examples of the construction and manipulation of cluster states, which are part of "one way computing" ideas, are included as an additional tool in the notebook Cluster.nb. A Mathematica palette containing most commands in QDENSITY is also included: QDENSpalette.nb. Program summaryTitle of program: QDENSITY Catalogue identifier: ADXH_v1_0 Program summary URL:http://cpc.cs.qub.ac.uk/summaries/ADXH_v1_0 Program available from: CPC Program Library, Queen's University of Belfast, N. Ireland Operating systems: Any which supports Mathematica; tested under Microsoft Windows XP, Macintosh OS X, and Linux FC4 Programming language used: Mathematica 5.2 No. of bytes in distributed program, including test data, etc.: 180 581 No. of lines in distributed program, including test data, etc.: 19 382 Distribution format: tar.gz Method of solution: A Mathematica package is provided which contains commands to create and analyze quantum circuits. Several Mathematica notebooks containing relevant examples: Teleportation, Shor's Algorithm and Grover's search are explained in detail. A tutorial, Tutorial.nb is also enclosed. QDENSITY is available at http://www.pitt.edu/~tabakin/QDENSITY.

The application of computers to learning in the Command and General Staff College (CGSC): A front end analysis study: CGSC analysis, Task A

DOE Office of Scientific and Technical Information (OSTI.GOV)

Thorn, C.T.

1988-01-01

The US Army Command and General Staff College (CGSC) is organized in five schools, one of which, Command and General Staff School (CGSS), is not formally established. These schools provide instruction to officers, noncommissioned officers, and civilians through 4 primary courses and approximately 20 shorter courses. The primary courses are CAS/sup 3/ (Combined Arms and Services Staff School) Phase I Nonresident Course, CAS/sup 3/ Phase II Resident Course, CGSOC (Command and General Staff Officers Course), and SAMS (School of Advanced Military Studies). The shorter courses are primarily provided through SPD (School of Professional Development). Task A analyzed the curricula ofmore » the primary courses in terms of organization and cognitive level with the goal of providing the project team sufficient understanding of the College to seriously address the issue of the application of computers to learning in Task G.« less

A day in the life of a volunteer incident commander: errors, pressures and mitigating strategies.

PubMed

Bearman, Christopher; Bremner, Peter A

2013-05-01

To meet an identified gap in the literature this paper investigates the tasks that a volunteer incident commander needs to carry out during an incident, the errors that can be made and the way that errors are managed. In addition, pressure from goal seduction and situation aversion were also examined. Volunteer incident commanders participated in a two-part interview consisting of a critical decision method interview and discussions about a hierarchical task analysis constructed by the authors. A SHERPA analysis was conducted to further identify potential errors. The results identified the key tasks, errors with extreme risk, pressures from strong situations and mitigating strategies for errors and pressures. The errors and pressures provide a basic set of issues that need to be managed by both volunteer incident commanders and fire agencies. The mitigating strategies identified here suggest some ways that this can be done. Copyright © 2012 Elsevier Ltd and The Ergonomics Society. All rights reserved.

Smoke Emission Tests on Series II and Series III Allison T56 Turboprop Engines

DTIC Science & Technology

1986-12-01

Buioary ■ (13) available to ARL of aromatic content of AVTUR from Australian sources. The US data was obtained from information contained in Sheldon...Library Flight Standards Division Statutory and State Authorities and Industry Australian Atomic Energy Commiasion, Director Australian Airlines...Ampol Petroleum (Vic) Pty Md, Lubricant Sales & Service Mgr Ansett Airlines of Australia, Library Australian Coal Industry Research Labs

Proceedings of the Annual Meeting of the Association for Education in Journalism and Mass Communication (82nd, New Orleans, Louisiana, August 3-8, 1999). Mass Communication and Society.

ERIC Educational Resources Information Center

Association for Education in Journalism and Mass Communication.

The Mass Communication and Society section of the Proceedings contains the following 17 papers: "Interactivity and the 'Cyber-Fan': Audience Involvement within the Electronic Fan Culture of the Internet" (Vic Costello); "A Reassessment of the Relationship between Public Affairs Media Use and Political Orientations" (Kim A.…

Regional hydrologic response to climate change in the conterminous United States using high-resolution hydroclimate simulations

DOE PAGES

Kao, Shih -Chieh; Ashfaq, Moetasim; Mei, Rui; ...

2016-06-16

Despite the fact that Global Climate Model (GCM) outputs have been used to project hydrologic impacts of climate change using off-line hydrologic models for two decades, many of these efforts have been disjointed applications or at least calibrations have been focused on individual river basins and using a few of the available GCMs. This study improves upon earlier attempts by systematically projecting hydrologic impacts for the entire conterminous United States (US), using outputs from ten GCMs from the latest Coupled Model Intercomparison Project phase 5 (CMIP5) archive, with seamless hydrologic model calibration and validation techniques to produce a spatially andmore » temporally consistent set of current hydrologic projections. The Variable Infiltration Capacity (VIC) model was forced with ten-member ensemble projections of precipitation and air temperature that were dynamically downscaled using a regional climate model (RegCM4) and bias-corrected to 1/24 (~4 km) grid resolution for the baseline (1966 2005) and future (2011 2050) periods under the Representative Concentration Pathway 8.5. Based on regional analysis, the VIC model projections indicate an increase in winter and spring total runoff due to increases in winter precipitation of up to 20% in most regions of the US. However, decreases in snow water equivalent (SWE) and snow-covered days will lead to significant decreases in summer runoff with more pronounced shifts in the time of occurrence of annual peak runoff projected over the eastern and western US. In contrast, the central US will experience year-round increases in total runoff, mostly associated with increases in both extreme high and low runoff. Furthermore, the projected hydrological changes described in this study have implications for various aspects of future water resource management, including water supply, flood and drought preparation, and reservoir operation.« less

Effect of thyroid status on the expression of metabolic enzymes during chronic stimulation.

PubMed

Hood, D A; Simoneau, J A; Kelly, A M; Pette, D

1992-10-01

The effect of thyroid status on the expression of cytochrome c oxidase (CYTOX) and the activities of citrate synthase (CS) and phosphofructokinase (PFK) were examined in chronically stimulated (10 Hz; 35 days) and contralateral, nonstimulated rat tibialis anterior muscle of hypothyroid, hyperthyroid, and euthyroid animals. Stimulation increased CYTOX activity by 2.7-, 3.2-, and 4.9-fold in hyperthyroid, euthyroid, and hypothyroid animals, respectively, to similar absolute values. CS displayed similar increases. Stimulation reduced PFK activity in hypothyroid and euthyroid animals to 45% and 60% of control values. This effect was abolished with hyperthyroidism. Thus stimulation and thyroid hormone act antagonistically on PFK activity. Stimulation increased CYTOX subunit III (mitochondrially encoded) mRNA by 2.5- and 2.9-fold in hyperthyroid and euthyroid animals. Similar increases were observed in the nuclear-encoded mRNAs of CYTOX subunit VIc in euthyroid muscle. In hyperthyroid and euthyroid conditions, the mRNA changes paralleled the increases in enzyme activity. In hypothyroid muscle, the increase in mRNA was less for subunit VIc than III, suggesting that hypothyroidism upsets the coordinate expression of nuclear and mitochondrial genes. Further, the increases in CYTOX activity exceeded that of both subunit mRNAs in hypothyroid muscle.(ABSTRACT TRUNCATED AT 250 WORDS)

Basin-Scale Assessment of the Land Surface Water Budget in the National Centers for Environmental Prediction Operational and Research NLDAS-2 Systems

NASA Technical Reports Server (NTRS)

Xia, Youlong; Cosgrove, Brian A.; Mitchell, Kenneth E.; Peters-Lidard, Christa D.; Ek, Michael B.; Brewer, Michael; Mocko, David; Kumar, Sujay V.; Wei, Helin; Meng, Jesse;

Surface Water and Energy Budgets for Sub-Saharan Africa in GFDL Coupled Climate Model

NASA Astrophysics Data System (ADS)

Tian, D.; Wood, E. F.; Vecchi, G. A.; Jia, L.; Pan, M.

2015-12-01

This study compare surface water and energy budget variables from the Geophysical Fluid Dynamics Laboratory (GFDL) FLOR models with the National Centers for Environmental Prediction (NCEP) Climate Forecast System Reanalysis (CFSR), Princeton University Global Meteorological Forcing Dataset (PGF), and PGF-driven Variable Infiltration Capacity (VIC) model outputs, as well as available observations over the sub-Saharan Africa. The comparison was made for four configurations of the FLOR models that included FLOR phase 1 (FLOR-p1) and phase 2 (FLOR-p2) and two phases of flux adjusted versions (FLOR-FA-p1 and FLOR-FA-p2). Compared to p1, simulated atmospheric states in p2 were nudged to the Modern-Era Retrospective Analysis for Research and Applications (MERRA) reanalysis. The seasonal cycle and annual mean of major surface water (precipitation, evapotranspiration, runoff, and change of storage) and energy variables (sensible heat, ground heat, latent heat, net solar radiation, net longwave radiation, and skin temperature) over a 34-yr period during 1981-2014 were compared in different regions in sub-Saharan Africa (West Africa, East Africa, and Southern Africa). In addition to evaluating the means in three sub-regions, empirical orthogonal functions (EOFs) analyses were conducted to compare both spatial and temporal characteristics of water and energy budget variables from four versions of GFDL FLOR, NCEP CFSR, PGF, and VIC outputs. This presentation will show how well each coupled climate model represented land surface physics and reproduced spatiotemporal characteristics of surface water and energy budget variables. We discuss what caused differences in surface water and energy budgets in land surface components of coupled climate model, climate reanalysis, and reanalysis driven land surface model. The comparisons will reveal whether flux adjustment and nudging would improve depiction of the surface water and energy budgets in coupled climate models.

AIROscope: Ames infrared balloon-borne telescope

NASA Technical Reports Server (NTRS)

Koontz, O. L.; Scott, S. G.

1974-01-01

A balloon-borne telescope system designed for astronomical observations at infrared wavelengths is discussed. The telescope is gyro-stabilized with updated pointing information derived from television, star tracker, or ground commands. The television system furnishes both course and fine acquisition after initial orientation using a pair of fluxgate servo compasses. Command and control is by a UHF link with 256 commands available. Scientific and engineering data are telemetered to the ground station via narrow band F.M. in the L band. The ground station displays all scientific, engineering and status information during the flights and records the command and telemetry digital bit stream for detailed analysis. The AIROscope telescope has a 28-inch diameter primary mirror and Dall-Kirkham optics. The beam is modulated by oscillating a secondary mirror at 11 or 25 Hz with provision for left or right beam fixed positions by command.

Using the Autism Detection in Early Childhood (ADEC) and Childhood Autism Rating Scales (CARS) to Predict Long Term Outcomes in Children with Autism Spectrum Disorders

ERIC Educational Resources Information Center

Nah, Yong-Hwee; Young, Robyn L.; Brewer, Neil

2014-01-01

This study evaluated the predictive validity of the Autism Detection in Early Childhood (ADEC; Young, Autism detection in early childhood: ADEC. Australian Council of Educational Research, Camberwell, VIC 2007) and a well-established screening tool, the Childhood Autism Rating Scale (CARS; Schopler et al. The childhood autism rating scale (CARS).…

Airborne Evaluation and Demonstration of a Time-Based Airborne Inter-Arrival Spacing Tool

NASA Technical Reports Server (NTRS)

Lohr, Gary W.; Oseguera-Lohr, Rosa M.; Abbott, Terence S.; Capron, William R.; Howell, Charles T.

2005-01-01

An airborne tool has been developed that allows an aircraft to obtain a precise inter-arrival time-based spacing interval from the preceding aircraft. The Advanced Terminal Area Approach Spacing (ATAAS) tool uses Automatic Dependent Surveillance-Broadcast (ADS-B) data to compute speed commands for the ATAAS-equipped aircraft to obtain this inter-arrival spacing behind another aircraft. The tool was evaluated in an operational environment at the Chicago O'Hare International Airport and in the surrounding terminal area with three participating aircraft flying fixed route area navigation (RNAV) paths and vector scenarios. Both manual and autothrottle speed management were included in the scenarios to demonstrate the ability to use ATAAS with either method of speed management. The results on the overall delivery precision of the tool, based on a target spacing of 90 seconds, were a mean of 90.8 seconds with a standard deviation of 7.7 seconds. The results for the RNAV and vector cases were, respectively, M=89.3, SD=4.9 and M=91.7, SD=9.0.

Vectorial Command of Induction Motor Pumping System Supplied by a Photovoltaic Generator

NASA Astrophysics Data System (ADS)

Makhlouf, Messaoud; Messai, Feyrouz; Benalla, Hocine

2011-01-01

With the continuous decrease of the cost of solar cells, there is an increasing interest and needs in photovoltaic (PV) system applications following standard of living improvements. Water pumping system powered by solar-cell generators are one of the most important applications. The fluctuation of solar energy on one hand, and the necessity to optimise available solar energy on the other, it is useful to develop new efficient and flexible modes to control motors that entrain the pump. A vectorial control of an asynchronous motor fed by a photovoltaic system is proposed. This paper investigates a photovoltaic-electro mechanic chain, composed of a PV generator, DC-AC converter, a vector controlled induction motor and centrifugal pump. The PV generator is forced to operate at its maximum power point by using an appropriate search algorithm integrated in the vector control. The optimization is realized without need to adding a DC-DC converter to the chain. The motor supply is also ensured in all insolation conditions. Simulation results show the effectiveness and feasibility of such an approach.

The Big Issue: Command and Combat in the Information Age

DTIC Science & Technology

2003-02-01

a new construct might emerge based on sensing forces, strike forces and manoeuvre forces.5 Whatever the outcome , an agile and razor-sharp command...wide range of mission support functions carried out in the home base – including intelligence, legal support, course of action analysis and operational... analysis as well as rear- based logistics. At the strategic level, once a major expeditionary operation is underway, rear operations might also embrace

Mission Command in the Age of Network-Enabled Operations: Social Network Analysis of Information Sharing and Situation Awareness

DTIC Science & Technology

2016-06-22

this assumption in a large-scale, 2-week military training exercise. We conducted a social network analysis of email communications among the multi...exponential random graph models challenge the aforementioned assumption, as increased email output was associated with lower individual situation... email links were more commonly formed among members of the command staff with both similar functions and levels of situation awareness, than between

Changes in abundance of vascular plants under varying silvicultural systems at the Forest Ecosystem Research and Demonstration Area, Paul Smiths, New York

Treesearch

Mark J. Twery; Elizabeth Olson; Gary L. Wade; Michael. Rechlin

2013-01-01

The Forest Ecosystem Research and Demonstration Area (FERDA) was established in 1998 adjacent to the Visitor Interpretive Center (VIC) for the Adirondack Park in Paul Smiths, NY, to provide visitors with first-hand exposure to forest management activities and to provide research opportunities for scientists and students at Paul Smith's College. This research note...

Evaluation of head orientation and neck muscle EMG signals as three-dimensional command sources.

PubMed

Williams, Matthew R; Kirsch, Robert F

2015-03-05

High cervical spinal cord injuries result in significant functional impairments and affect both the injured individual as well as their family and care givers. To help restore function to these individuals, multiple user interfaces are available to enable command and control of external devices. However, little work has been performed to assess the 3D performance of these interfaces. We investigated the performance of eight human subjects in using three user interfaces (head orientation, EMG from muscles of the head and neck, and a three-axis joystick) to command the endpoint position of a multi-axis robotic arm within a 3D workspace to perform a novel out-to-center 3D Fitts' Law style task. Two of these interfaces (head orientation, EMG from muscles of the head and neck) could realistically be used by individuals with high tetraplegia, while the joystick was evaluated as a standard of high performance. Performance metrics were developed to assess the aspects of command source performance. Data were analyzed using a mixed model design ANOVA. Fixed effects were investigated between sources as well as for interactions between index of difficulty, command source, and the five performance measures used. A 5% threshold for statistical significance was used in the analysis. The performances of the three command interfaces were rather similar, though significant differences between command sources were observed. The apparent similarity is due in large part to the sequential command strategy (i.e., one dimension of movement at a time) typically adopted by the subjects. EMG-based commands were particularly pulsatile in nature. The use of sequential commands had a significant impact on each command source's performance for movements in two or three dimensions. While the sequential nature of the commands produced by the user did not fit with Fitts' Law, the other performance measures used were able to illustrate the properties of each command source. Though pulsatile, given the overall similarity between head orientation and the EMG interface, (which also could be readily included in a future implanted neuroprosthesis) the use of EMG as a command source for controlling an arm in 3D space is an attractive choice.

The influence of ATC message length and timing on pilot communication

NASA Technical Reports Server (NTRS)

Morrow, Daniel; Rodvold, Michelle

1993-01-01

Pilot-controller communication is critical to safe and efficient flight. It is often a challenging component of piloting, which is reflected in the number of incidents and accidents involving miscommunication. Our previous field study identified communication problems that disrupt routine communication between pilots and controllers. The present part-task simulation study followed up the field results with a more controlled investigation of communication problems. Pilots flew a simulation in which they were frequently vectored by Air Traffic Control (ATC), requiring intensive communication with the controller. While flying, pilots also performed a secondary visual monitoring task. We examined the influence of message length (one message with four commands vs. two messages with two commands each) and noncommunication workload on communication accuracy and length. Longer ATC messages appeared to overload pilot working memory, resulting in more incorrect or partial readbacks, as well as more requests to repeat the message. The timing between the two short messages also influenced communication. The second message interfered with memory for or response to the first short message when it was delivered too soon after the first message. Performing the secondary monitoring task did not influence communication. Instead, communication reduced monitoring accuracy.

Senior Executive Service. Executives' Perspectives on Their Federal Service. Fact Sheet for the Honorable Vic Fazio, House of Representatives.

ERIC Educational Resources Information Center

General Accounting Office, Washington, DC. General Government Div.

The General Accounting Office (GAO) surveyed current Senior Executive Service (SES) (highly placed government civil service) employees to obtain their views regarding their federal employment, including career plans, characteristics, and opinions. The results of the survey were obtained from 348 usable responses from a sample of 430 SES members…

Future Visions of the Brahmaputra - Establishing Hydrologic Baseline and Water Resources Context

NASA Astrophysics Data System (ADS)

Ray, P. A.; Yang, Y. E.; Wi, S.; Brown, C. M.

2013-12-01

The Brahmaputra River Basin (China-India-Bhutan-Bangladesh) is on the verge of a transition from a largely free flowing and highly variable river to a basin of rapid investment and infrastructure development. This work demonstrates a knowledge platform for the basin that compiles available data, and develops hydrologic and water resources system models of the basin. A Variable Infiltration Capacity (VIC) model of the Brahmaputra basin supplies hydrologic information of major tributaries to a water resources system model, which routes runoff generated via the VIC model through water infrastructure, and accounts for water withdrawals for agriculture, hydropower generation, municipal demand, return flows and others human activities. The system model also simulates agricultural production and the economic value of water in its various uses, including municipal, agricultural, and hydropower. Furthermore, the modeling framework incorporates plausible climate change scenarios based on the latest projections of changes to contributing glaciers (upstream), as well as changes to monsoon behavior (downstream). Water resources projects proposed in the Brahmaputra basin are evaluated based on their distribution of benefits and costs in the absence of well-defined water entitlements, and relative to a complex regional water-energy-food nexus. Results of this project will provide a basis for water sharing negotiation among the four countries and inform trans-national water-energy policy making.

Parallel-vector computation for linear structural analysis and non-linear unconstrained optimization problems

NASA Technical Reports Server (NTRS)

Nguyen, D. T.; Al-Nasra, M.; Zhang, Y.; Baddourah, M. A.; Agarwal, T. K.; Storaasli, O. O.; Carmona, E. A.

1991-01-01

Several parallel-vector computational improvements to the unconstrained optimization procedure are described which speed up the structural analysis-synthesis process. A fast parallel-vector Choleski-based equation solver, pvsolve, is incorporated into the well-known SAP-4 general-purpose finite-element code. The new code, denoted PV-SAP, is tested for static structural analysis. Initial results on a four processor CRAY 2 show that using pvsolve reduces the equation solution time by a factor of 14-16 over the original SAP-4 code. In addition, parallel-vector procedures for the Golden Block Search technique and the BFGS method are developed and tested for nonlinear unconstrained optimization. A parallel version of an iterative solver and the pvsolve direct solver are incorporated into the BFGS method. Preliminary results on nonlinear unconstrained optimization test problems, using pvsolve in the analysis, show excellent parallel-vector performance indicating that these parallel-vector algorithms can be used in a new generation of finite-element based structural design/analysis-synthesis codes.

Experimental Design and Analysis of M1A1 Commander/Gunner Performance during CONOPS (Continuous Operations) Using the U-COFT (Unit Conduct of Fire Trainer)

DTIC Science & Technology

1989-09-01

gun b. 7.62-mm coax manchine gun c. Commander’s weapon station caliber .50 machine gun d. M250 grenade launchers 2. Ammunition Simulation a. 105-mm...7.62-mm machine gun f. M250 smoke grenades 3. Normal Mode Simulation a. Stabilized coax machine gun b. Stabilized main gun c. Commander’s weapon d

Modeling and Simulation of Avionics Systems and Command, Control and Communications Systems

DTIC Science & Technology

1980-01-01

analytical and operational talent into a cohesive study group . This group becomes our critical mass for innovative analysis. For command and control problems...that focusing small integrated groups on specific aspects of a command and control problem sucoseds best. For example, Air Force Studies and Analyses...phase so called " study groups " should define "tactical requirement-papers", These study groups will be supported by operational analyses and by

Critical Analysis of the Mathematical Formalism of Theoretical Physics. II. Foundations of Vector Calculus

NASA Astrophysics Data System (ADS)

Kalanov, Temur Z.

2014-03-01

A critical analysis of the foundations of standard vector calculus is proposed. The methodological basis of the analysis is the unity of formal logic and of rational dialectics. It is proved that the vector calculus is incorrect theory because: (a) it is not based on a correct methodological basis - the unity of formal logic and of rational dialectics; (b) it does not contain the correct definitions of ``movement,'' ``direction'' and ``vector'' (c) it does not take into consideration the dimensions of physical quantities (i.e., number names, denominate numbers, concrete numbers), characterizing the concept of ''physical vector,'' and, therefore, it has no natural-scientific meaning; (d) operations on ``physical vectors'' and the vector calculus propositions relating to the ''physical vectors'' are contrary to formal logic.

The assisted prediction modelling frame with hybridisation and ensemble for business risk forecasting and an implementation

NASA Astrophysics Data System (ADS)

Li, Hui; Hong, Lu-Yao; Zhou, Qing; Yu, Hai-Jie

2015-08-01

The business failure of numerous companies results in financial crises. The high social costs associated with such crises have made people to search for effective tools for business risk prediction, among which, support vector machine is very effective. Several modelling means, including single-technique modelling, hybrid modelling, and ensemble modelling, have been suggested in forecasting business risk with support vector machine. However, existing literature seldom focuses on the general modelling frame for business risk prediction, and seldom investigates performance differences among different modelling means. We reviewed researches on forecasting business risk with support vector machine, proposed the general assisted prediction modelling frame with hybridisation and ensemble (APMF-WHAE), and finally, investigated the use of principal components analysis, support vector machine, random sampling, and group decision, under the general frame in forecasting business risk. Under the APMF-WHAE frame with support vector machine as the base predictive model, four specific predictive models were produced, namely, pure support vector machine, a hybrid support vector machine involved with principal components analysis, a support vector machine ensemble involved with random sampling and group decision, and an ensemble of hybrid support vector machine using group decision to integrate various hybrid support vector machines on variables produced from principle components analysis and samples from random sampling. The experimental results indicate that hybrid support vector machine and ensemble of hybrid support vector machines were able to produce dominating performance than pure support vector machine and support vector machine ensemble.

Command History for 1990

DTIC Science & Technology

1991-05-01

Marine Corps Tiaining Systems (CBESS) memorization training Inteligence Center, Dam Neck Threat memorization training Commander Tactical Wings, Atlantic...News Shipbuilding Technical training AEGIS Training Center, Dare Artificial Intelligence (Al) Tools Computerized firm-end analysis tools NETSCPAC...Technology Department and provides computational and electronic mail support for research in areas of artificial intelligence, computer-assisted instruction

Singularity-free extraction of a quaternion from a direction-cosine matrix. [for spacecraft control and guidance

NASA Technical Reports Server (NTRS)

Klumpp, A. R.

1976-01-01

A computer algorithm for extracting a quaternion from a direction-cosine matrix (DCM) is described. The quaternion provides a four-parameter representation of rotation, as against the nine-parameter representation afforded by a DCM. Commanded attitude in space shuttle steering is conveniently computed by DCM, while actual attitude is computed most compactly as a quaternion, as is attitude error. The unit length of the rotation quaternion, and interchangeable of a quaternion and its negative, are used to advantage in the extraction algorithm. Protection of the algorithm against square root failure and division overflow are considered. Necessary and sufficient conditions for handling the rotation vector element of largest magnitude are discussed

The Newick utilities: high-throughput phylogenetic tree processing in the UNIX shell.

PubMed

Junier, Thomas; Zdobnov, Evgeny M

2010-07-01

We present a suite of Unix shell programs for processing any number of phylogenetic trees of any size. They perform frequently-used tree operations without requiring user interaction. They also allow tree drawing as scalable vector graphics (SVG), suitable for high-quality presentations and further editing, and as ASCII graphics for command-line inspection. As an example we include an implementation of bootscanning, a procedure for finding recombination breakpoints in viral genomes. C source code, Python bindings and executables for various platforms are available from http://cegg.unige.ch/newick_utils. The distribution includes a manual and example data. The package is distributed under the BSD License. thomas.junier@unige.ch

SVG-Based Web Publishing

NASA Astrophysics Data System (ADS)

Gao, Jerry Z.; Zhu, Eugene; Shim, Simon

2003-01-01

With the increasing applications of the Web in e-commerce, advertising, and publication, new technologies are needed to improve Web graphics technology due to the current limitation of technology. The SVG (Scalable Vector Graphics) technology is a new revolutionary solution to overcome the existing problems in the current web technology. It provides precise and high-resolution web graphics using plain text format commands. It sets a new standard for web graphic format to allow us to present complicated graphics with rich test fonts and colors, high printing quality, and dynamic layout capabilities. This paper provides a tutorial overview about SVG technology and its essential features, capability, and advantages. The reports a comparison studies between SVG and other web graphics technologies.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Collins, Benjamin S.

The Futility package contains the following: 1) Definition of the size of integers and real numbers; 2) A generic Unit test harness; 3) Definitions for some basic extensions to the Fortran language: arbitrary length strings, a parameter list construct, exception handlers, command line processor, timers; 4) Geometry definitions: point, line, plane, box, cylinder, polyhedron; 5) File wrapper functions: standard Fortran input/output files, Fortran binary files, HDF5 files; 6) Parallel wrapper functions: MPI, and Open MP abstraction layers, partitioning algorithms; 7) Math utilities: BLAS, Matrix and Vector definitions, Linear Solver methods and wrappers for other TPLs (PETSC, MKL, etc), preconditioner classes;more » 8) Misc: random number generator, water saturation properties, sorting algorithms.« less

The COMMAND trial of cognitive therapy to prevent harmful compliance with command hallucinations: predictors of outcome and mediators of change.

PubMed

Birchwood, Max; Dunn, Graham; Meaden, Alan; Tarrier, Nicholas; Lewis, Shon; Wykes, Til; Davies, Linda; Michail, Maria; Peters, Emmanuelle

2017-12-05

Acting on harmful command hallucinations is a major clinical concern. Our COMMAND CBT trial approximately halved the rate of harmful compliance (OR = 0.45, 95% CI 0.23-0.88, p = 0.021). The focus of the therapy was a single mechanism, the power dimension of voice appraisal, was also significantly reduced. We hypothesised that voice power differential (between voice and voice hearer) was the mediator of the treatment effect. The trial sample (n = 197) was used. A logistic regression model predicting 18-month compliance was used to identify predictors, and an exploratory principal component analysis (PCA) of baseline variables used as potential predictors (confounders) in their own right. Stata's paramed command used to obtain estimates of the direct, indirect and total effects of treatment. Voice omnipotence was the best predictor although the PCA identified a highly predictive cognitive-affective dimension comprising: voices' power, childhood trauma, depression and self-harm. In the mediation analysis, the indirect effect of treatment was fully explained by its effect on the hypothesised mediator: voice power differential. Voice power and treatment allocation were the best predictors of harmful compliance up to 18 months; post-treatment, voice power differential measured at nine months was the mediator of the effect of treatment on compliance at 18 months.

Ammunition Cost Research Study

DTIC Science & Technology

1976-06-01

LIBRARY TECHNICAL REPORT Gerald W. Kalal Patrick J. Gannon COST ANALYSIS DIVISION (DRSAR-CPE) HEADQUARTERS, U.S. ARMY ARMAMENT COMMAND ROCK ISLAND... Kalal trick J. Gannon COST ANALYSIS DIVISION (DRSAR-CPE) HEADQUARTERS, U.S. ARMY ARMAMENT COMMAND ROCK ISLAND, ILLINOIS 61201 I UNCLASSIFIED...4. DESCRIPTIVE NOTES (Type ot report and Inclusive date») Technical Report 8- AU THOR(S> (flral name, middle Initial, laat name) Gerald W. Kalal

A distributed Petri Net controller for a dual arm testbed

NASA Technical Reports Server (NTRS)

Bjanes, Atle

1991-01-01

This thesis describes the design and functionality of a Distributed Petri Net Controller (DPNC). The controller runs under X Windows to provide a graphical interface. The DPNC allows users to distribute a Petri Net across several host computers linked together via a TCP/IP interface. A sub-net executes on each host, interacting with the other sub-nets by passing a token vector from host to host. One host has a command window which monitors and controls the distributed controller. The input to the DPNC is a net definition file generated by Great SPN. Thus, a net may be designed, analyzed and verified using this package before implementation. The net is distributed to the hosts by tagging transitions that are host-critical with the appropriate host number. The controller will then distribute the remaining places and transitions to the hosts by generating the local nets, the local marking vectors and the global marking vector. Each transition can have one or more preconditions which must be fulfilled before the transition can fire, as well as one or more post-processes to be executed after the transition fires. These implement the actual input/output to the environment (machines, signals, etc.). The DPNC may also be used to simulate a Great SPN net since stochastic and deterministic firing rates are implemented in the controller for timed transitions.

Calling for the absent male.

PubMed

Edgar, D

1999-08-01

This is an edited version of a keynote address given by Dr Don Edgar at both the VicHealth Conference on 'Healthy Relationships in the Workplace' held in August 1998 and the Tasmanian Men's Health Conference held in Launceston in November 1998. Men's lack of communication skills and emotional intelligence has serious negative consequences for their own physical and mental health, the wellbeing of their families and for the quality of their performance in the workplace.

Nuclear data made easily accessible through the Notre Dame Nuclear Database

NASA Astrophysics Data System (ADS)

Khouw, Timothy; Lee, Kevin; Fasano, Patrick; Mumpower, Matthew; Aprahamian, Ani

2014-09-01

In 1994, the NNDC revolutionized nuclear research by providing a colorful, clickable, searchable database over the internet. Over the last twenty years, web technology has evolved dramatically. Our project, the Notre Dame Nuclear Database, aims to provide a more comprehensive and broadly searchable interactive body of data. The database can be searched by an array of filters which includes metadata such as the facility where a measurement is made, the author(s), or date of publication for the datum of interest. The user interface takes full advantage of HTML, a web markup language, CSS (cascading style sheets to define the aesthetics of the website), and JavaScript, a language that can process complex data. A command-line interface is supported that interacts with the database directly on a user's local machine which provides single command access to data. This is possible through the use of a standardized API (application programming interface) that relies upon well-defined filtering variables to produce customized search results. We offer an innovative chart of nuclides utilizing scalable vector graphics (SVG) to deliver users an unsurpassed level of interactivity supported on all computers and mobile devices. We will present a functional demo of our database at the conference.

The Army Study Program Fiscal Year 1992 Report

DTIC Science & Technology

1991-11-25

Investigation Command (ATTN: CIRM-M-S) 2 US Army Military District of Washington (ATTN: ANRM-RE) 2 US Army Health Services Command (ATTN: HSCM-R) 2 US Army...0 QA AM40 SURVEILLANCE TASK COST ANALYSIS (TCA) 1 9003 9004 AMC MEA AMQEI01C 0 SUPPLY AND SERVICES TASK COST ANALYSIS (TCA) ( 1 9003 9004 AMC MEA 4...CONFLICT MODEL DEVELOPMENT 1 9110 9210 TRADOC T/OAC ATRCLMOC1 P COMBAT SERVICE SUPPORT FORCE DESIGN ANALYSIS 2 9110 9212 TRADOC T/LEE ATRCLMOC2 P

Vectorized Monte Carlo methods for reactor lattice analysis

NASA Technical Reports Server (NTRS)

Brown, F. B.

1984-01-01

Some of the new computational methods and equivalent mathematical representations of physics models used in the MCV code, a vectorized continuous-enery Monte Carlo code for use on the CYBER-205 computer are discussed. While the principal application of MCV is the neutronics analysis of repeating reactor lattices, the new methods used in MCV should be generally useful for vectorizing Monte Carlo for other applications. For background, a brief overview of the vector processing features of the CYBER-205 is included, followed by a discussion of the fundamentals of Monte Carlo vectorization. The physics models used in the MCV vectorized Monte Carlo code are then summarized. The new methods used in scattering analysis are presented along with details of several key, highly specialized computational routines. Finally, speedups relative to CDC-7600 scalar Monte Carlo are discussed.

Vascular Plant Species of the Forest Ecology Research and Demonstration Area, Paul Smith's, New York

Treesearch

Gary L. Wade; Jonathan A. Myers; Cecilia R. Martin; Kathie Detmar; William, III Mator; Mark J. Twery; Mike Rechlin

2003-01-01

Five forest harvest methods (single-tree selection, group selection, two-age cut, shelterwood cut, and clearcut) are being demonstrated on 5-acre tracts near the Adirondack Park Agency?s Visitor Interpretation Center (VIC) at Paul Smith?s, New York. The tracts are part of the agency?s Forest Ecology Research and Demonstration Area. A primary goal is to show visitors...

Mécanique de Nonéquilibre à la Californienne

NASA Astrophysics Data System (ADS)

Hoover, Wm. G.

1997-02-01

Academic freedom, combined with generous travel grants and tax-supported computing, made possible my 35 years' study of many-body problems. Here I first review some of the many high points of those years. I then describe recent work - with Harald Posch, Oyeon Kum, my wife Carol, Siegfried Hess, and Vic Castillo - which links together particle and continuum mechanics through “SPAM”, Smooth Particle Applied Mechanics.

Correlation between polar values and vector analysis.

PubMed

Naeser, K; Behrens, J K

1997-01-01

To evaluate the possible correlation between polar value and vector analysis assessment of surgically induced astigmatism. Department of Ophthalmology, Aalborg Sygehus Syd, Denmark. The correlation between polar values and vector analysis was evaluated by simple mathematical and optical methods using accepted principles of trigonometry and first-order optics. Vector analysis and polar values report different aspects of surgically induced astigmatism. Vector analysis describes the total astigmatic change, characterized by both astigmatic magnitude and direction, while the polar value method produces a single, reduced figure that reports flattening or steepening in preselected directions, usually the plane of the surgical meridian. There is a simple Pythagorean correlation between vector analysis and two polar values separated by an arch of 45 degrees. The polar value calculated in the surgical meridian indicates the power or the efficacy of the surgical procedure. The polar value calculated in a plane inclined 45 degrees to the surgical meridian indicates the degree of cylinder rotation induced by surgery. These two polar values can be used to obtain other relevant data such as magnitude, direction, and sphere of an induced cylinder. Consistent use of these methods will enable surgeons to control and in many cases reduce preoperative astigmatism.

Response to the Directorate of Health Care Studies and Clinical Investigations Final Report (Revised) Assessing Power Analysis Approaches for the Fort Bragg Evaluation Project

DTIC Science & Technology

1993-07-28

Below is a summary of Vanderbilt’s response, requested by Health Services Command ( HSC ), to the final report prepared by the Directorate of Health Care...Command’s ( HSC ) demands for client data it sought to use somehow in power analysis (see Appendix F). Dr. Kapadia’s statement is the standard view held...not involve actual data, the results from this method may be entirely misleading and not accurate." When HSC demanded client data for power analysis in

Stability Properties and Cross Coupling Performance of the Control Allocation Scheme CAPIO

NASA Technical Reports Server (NTRS)

Yildiz, Yildiray; Kolmanovsky, Ilya V.

2010-01-01

This paper presents a stability analysis and an application of a recently developed Control Allocator for recovery from Pilot Induced Oscillations (CAPIO). When actuators are rate-saturated due to either aggressive pilot commands, high gain ight control systems or some anomaly in the system, the effective delay in the control loop may increase. This effective delay increase manifests itself as a phase shift between the commanded and actual system signals and can instigate Pilot induced Oscillations (PIO). CAPIO reduces the e ective time delay by minimizing the phase shift between the commanded and the actual attitude accelerations. We present a stability analysis of CAPIO for a scalar system. In addition, we present simulation results for aircraft with cross-coupling which demonstrates the potential of CAPIO serving as an effective PIO handler in adverse conditions.

Organizing for Effective Joint Warfare: A Deductive Analysis of U.S. Armed Forces Joint Doctrine

DTIC Science & Technology

1993-06-18

8217, Unpublished SAMS Monogram , (U.S. Army Command and General Staff College, Fort Leavenworth, KS: i988) p. 25. 3. Frank 0. Hough, et al, History of...SAMS Monogram , (U.S. Army Command and General Staff College, Fort Leavenworth, KS: 1988) , p, 16 and p. 29; and William 0. Pierce, ’Span of Control and...The Operational Commandetr: Is it More Than Just a Nun:ber?", Unpublished SAMS Monogram , (U.S. Army Command and Ueneral Staff College, Fort Leavenworth

Leaders in space: Mission commanders and crew on the International Space Station

NASA Astrophysics Data System (ADS)

Brcic, Jelena

Understanding the relationship between leaders and their subordinates is important for building better interpersonal connections, improving group cohesion and cooperation, and increasing task success. This relationship has been examined in many types of groups but not a great amount of analysis has been applied to spaceflight crews. We specifically investigated differences between mission commanders and flight commanders during missions to the International Space Station (ISS). Astronauts and cosmonauts on the ISS participate in long-duration missions (2 to 6 months in length) in which they live and work in close proximity with their 2 or 3 member crews. The leaders are physically distant from their command centres which may result in delay of instructions or important advice. Therefore, the leaders must be able to make quick, sound decisions with unwavering certainty. Potential complications include that the leaders may not be able to exercise their power fully, since material reward or punishment of any one member affects the whole group, and that the leader's actions (or lack thereof) in this isolated, confined environment could create stress in members. To be effective, the mission commander must be able to prevent or alleviate any group conflict and be able to relate to members on an emotional level. Mission commanders and crew are equal in the competencies of spaceflight; therefore, what are the unique characteristics that enable the commanders to fulfill their role? To highlight the differences between commander and crew, astronaut journals, diaries, pre- flight interviews, NASA oral histories, and letters written to family from space were scored and analyzed for values and coping styles. During pre-flight, mission commanders scored higher than other crew members on the values of Stimulation, Security, Universalism, Conformity, Spirituality, and Benevolence, and more often used Self-Control as a coping style. During the long-duration mission on ISS, mission commanders scored higher than crew on the coping style of Accepting Responsibility. These results improve our understanding of the similarities and differences between mission commanders and crew, and suggest areas of importance for the selection and training of future commanders.

Prompt comprehension in UNIX command production.

PubMed

Doane, S M; McNamara, D S; Kintsch, W; Polson, P G; Clawson, D M

1992-07-01

We hypothesize that a cognitive analysis based on the construction-integration theory of comprehension (Kintsch, 1988) can predict what is difficult about generating complex composite commands in the UNIX operating system. We provide empirical support for assumptions of the Doane, Kintsch, and Polson (1989, 1990) construction-integration model for generating complex commands in UNIX. We asked users whose UNIX experience varied to produce complex UNIX commands, and then provided help prompts whenever the commands that they produced were erroneous. The help prompts were designed to assist subjects with respect to both the knowledge and the memory processes that our UNIX modeling efforts have suggested are lacking in less expert users. It appears that experts respond to different prompts than do novices. Expert performance is helped by the presentation of abstract information, whereas novice and intermediate performance is modified by presentation of concrete information. Second, while presentation of specific prompts helps less expert subjects, they do not provide sufficient information to obtain correct performance. Our analyses suggest that information about the ordering of commands is required to help the less expert with both knowledge and memory load problems in a manner consistent with skill acquisition theories.

Command and Control Analysis of the South West Provincial Regional Emergency Operations Centre during Vancouver 2010

DTIC Science & Technology

2011-06-01

Venue Site WACC - Whistler Area Command Centre OTHER GPPAG - Government Partners Public Affairs Group 18 ANNEX B. Interview questions...Vancouver Vancouver Richmond WACC Decision Authority Link Information Sharing Link DOC’s 2010 Provincial Games Secretariat GPPAG CCG

Irondequoit Creek Watershed New York, Final Feasibility Report and Environmental Impact Statement.

DTIC Science & Technology

1982-03-01

National Flood Insurance Program 58 8 System of Accounts 95 9 Summary of Benefits and Costs 96 10 Summary of Average Annual Benefits - Selected Plan 112...material, velocity distribution, vegetation, soil type, topography, and especially rainfall regime, where a few intense storms can account for severe...Alternative B is described later in this report. Flood Insurance - Flood insurance provides some financial protection to vic- tims of flood related

A Simple Model of Circuit Design.

DTIC Science & Technology

1980-05-01

mathematicians who discover mathematical ideas (i.cnat>, programmers who write code <Manna> <Barstow>, physicists who solve mechanics problems <de Kiecr-l...rules and shows how - they result in the design of circuits. ’l’he design rules must not only capture the purely mathematical constralints given by VICs...K VI.. *? and KCI, but also how those constraints can implement mechanism. Mathematical constraints tell us an amplifier’s input and output voltages

An Alignment Analysis of the U.S. Navy Supply Corps Officer’s Career Guidance With Naval Supply Systems Command’s Strategic Publications

DTIC Science & Technology

2014-06-03

relationship to business outcomes such as customer satisfaction , turnover, safety, and productivity” (Shuck, 2011, p. 312). Follow-on studies using...during the analysis efforts of this research. The 339 Level 1 codes span a wide range of ideas from strategy execution to customer satisfaction and...not reflect the radical shift in corporate culture needed by Naval Supply Systems Command (NAVSUP) to better serve U.S. Navy customers . This research

Electromyographic decoding of response to command in disorders of consciousness.

PubMed

Lesenfants, Damien; Habbal, Dina; Chatelle, Camille; Schnakers, Caroline; Laureys, Steven; Noirhomme, Quentin

2016-11-15

To propose a new methodology based on single-trial analysis for detecting residual response to command with EMG in patients with disorders of consciousness (DOC), overcoming the issue of trial dependency and decreasing the influence of a patient's fluctuation of vigilance or arousal over time on diagnostic accuracy. Forty-five patients with DOC (18 with vegetative/unresponsive wakefulness syndrome [VS/UWS], 22 in a minimally conscious state [MCS], 3 who emerged from MCS [EMCS], and 2 with locked-in syndrome [LIS]) and 20 healthy controls were included in the study. Patients were randomly instructed to either move their left or right hand or listen to a control command ("It is a sunny day") while EMG activity was recorded on both arms. Differential EMG activity was detected in all MCS cases displaying reproducible response to command at bedside on multiple assessments, even though only 6 of the 14 individuals presented a behavioral response to command on the day of the EMG assessment. An EMG response was also detected in all EMCS and LIS patients, and 2 MCS patients showing nonreflexive movements without command following at the bedside. None of the VS/UWS presented a response to command with this method. This method allowed us to reliably distinguish between different levels of consciousness and could potentially help decrease diagnostic errors in patients with motor impairment but presenting residual motor activity. © 2016 American Academy of Neurology.

Impact of LULC change on the runoff, base flow and evapotranspiration dynamics in eastern Indian river basins during 1985-2005 using variable infiltration capacity approach

NASA Astrophysics Data System (ADS)

Das, Pulakesh; Behera, Mukunda Dev; Patidar, Nitesh; Sahoo, Bhabagrahi; Tripathi, Poonam; Behera, Priti Ranjan; Srivastava, S. K.; Roy, Partha Sarathi; Thakur, Praveen; Agrawal, S. P.; Krishnamurthy, Y. V. N.

2018-03-01

As a catchment phenomenon, land use and land cover change (LULCC) has a great role in influencing the hydrological cycle. In this study, decadal LULC maps of 1985, 1995, 2005 and predicted-2025 of the Subarnarekha, Brahmani, Baitarani, Mahanadi and Nagavali River basins of eastern India were analyzed in the framework of the variable infiltration capacity (VIC) macro scale hydrologic model to estimate their relative consequences. The model simulation showed a decrease in ET with 0.0276% during 1985-1995, but a slight increase with 0.0097% during 1995-2005. Conversely, runoff and base flow showed an overall increasing trend with 0.0319 and 0.0041% respectively during 1985-1995. In response to the predicted LULC in 2025, the VIC model simulation estimated reduction of ET with 0.0851% with an increase of runoff by 0.051%. Among the vegetation parameters, leaf area index (LAI) emerged as the most sensitive one to alter the simulated water balance. LULC alterations via deforestation, urbanization, cropland expansions led to reduced canopy cover for interception and transpiration that in turn contributed to overall decrease in ET and increase in runoff and base flow. This study reiterates changes in the hydrology due to LULCC, thereby providing useful inputs for integrated water resources management in the principle of sustained ecology.

Go Deeper, Go Deeper: Understanding submarine command and control during the completion of dived tracking operations.

PubMed

Roberts, Aaron P J; Stanton, Neville A; Fay, Daniel T

2018-05-01

This is a world's first-of-a-kind study providing empirical evidence for understanding submarine control room performance when completing higher and lower demand Dived Tracking (DT) scenarios. A submarine control room simulator was built, using a non-commercial version of Dangerous Waters as the simulation engine. The creation of networked workstations allowed a team of nine operators to perform tasks completed by submarine command teams during DT. The Event Analysis of Systemic Teamwork (EAST) method was used to model the social, task and information networks and describe command team performance. Ten teams were recruited for the study, affording statistical comparisons of how command team roles and level of demand affected performance. Results indicate that command teams can covertly DT a contact differently depending on demand (e.g. volume of contacts). In low demand it was possible to use periscope more often than in high demand, in a 'duck-and-run' fashion. Therefore, the type of information and frequency of particular task completion, was significantly different between the higher and lower demand conditions. This resulted in different operators in the command team experiencing greater demand depending on how the DT mission objective was completed. Potential bottlenecks in the command team were identified and implications are discussed alongside suggestions for future work. Copyright © 2018 Elsevier Ltd. All rights reserved.

Cattle phenotypes can disguise their maternal ancestry.

PubMed

Srirattana, Kanokwan; McCosker, Kieren; Schatz, Tim; St John, Justin C

2017-06-26

Cattle are bred for, amongst other factors, specific traits, including parasite resistance and adaptation to climate. However, the influence and inheritance of mitochondrial DNA (mtDNA) are not usually considered in breeding programmes. In this study, we analysed the mtDNA profiles of cattle from Victoria (VIC), southern Australia, which is a temperate climate, and the Northern Territory (NT), the northern part of Australia, which has a tropical climate, to determine if the mtDNA profiles of these cattle are indicative of breed and phenotype, and whether these profiles are appropriate for their environments. A phylogenetic tree of the full mtDNA sequences of different breeds of cattle, which were obtained from the NCBI database, showed that the mtDNA profiles of cattle do not always reflect their phenotype as some cattle with Bos taurus phenotypes had Bos indicus mtDNA, whilst some cattle with Bos indicus phenotypes had Bos taurus mtDNA. Using D-loop sequencing, we were able to contrast the phenotypes and mtDNA profiles from different species of cattle from the 2 distinct cattle breeding regions of Australia. We found that 67 of the 121 cattle with Bos indicus phenotypes from NT (55.4%) had Bos taurus mtDNA. In VIC, 92 of the 225 cattle with Bos taurus phenotypes (40.9%) possessed Bos indicus mtDNA. When focusing on oocytes from cattle with the Bos taurus phenotype in VIC, their respective oocytes with Bos indicus mtDNA had significantly lower levels of mtDNA copy number compared with oocytes possessing Bos taurus mtDNA (P < 0.01). However, embryos derived from oocytes with Bos indicus mtDNA had the same ability to develop to the blastocyst stage and the levels of mtDNA copy number in their blastocysts were similar to blastocysts derived from oocytes harbouring Bos taurus mtDNA. Nevertheless, oocytes originating from the Bos indicus phenotype exhibited lower developmental potential due to low mtDNA copy number when compared with oocytes from cattle with a Bos taurus phenotype. The phenotype of cattle is not always related to their mtDNA profiles. MtDNA profiles should be considered for breeding programmes as they also influence phenotypic traits and reproductive capacity in terms of oocyte quality.

Spacecraft attitude and velocity control system

NASA Technical Reports Server (NTRS)

Paluszek, Michael A. (Inventor); Piper, Jr., George E. (Inventor)

1992-01-01

A spacecraft attitude and/or velocity control system includes a controller which responds to at least attitude errors to produce command signals representing a force vector F and a torque vector T, each having three orthogonal components, which represent the forces and torques which are to be generated by the thrusters. The thrusters may include magnetic torquer or reaction wheels. Six difference equations are generated, three having the form ##EQU1## where a.sub.j is the maximum torque which the j.sup.th thruster can produce, b.sub.j is the maximum force which the j.sup.th thruster can produce, and .alpha..sub.j is a variable representing the throttling factor of the j.sup.th thruster, which may range from zero to unity. The six equations are summed to produce a single scalar equation relating variables .alpha..sub.j to a performance index Z: ##EQU2## Those values of .alpha. which maximize the value of Z are determined by a method for solving linear equations, such as a linear programming method. The Simplex method may be used. The values of .alpha..sub.j are applied to control the corresponding thrusters.

A High-Fidelity Batch Simulation Environment for Integrated Batch and Piloted Air Combat Simulation Analysis

NASA Technical Reports Server (NTRS)

Goodrich, Kenneth H.; McManus, John W.; Chappell, Alan R.

1992-01-01

A batch air combat simulation environment known as the Tactical Maneuvering Simulator (TMS) is presented. The TMS serves as a tool for developing and evaluating tactical maneuvering logics. The environment can also be used to evaluate the tactical implications of perturbations to aircraft performance or supporting systems. The TMS is capable of simulating air combat between any number of engagement participants, with practical limits imposed by computer memory and processing power. Aircraft are modeled using equations of motion, control laws, aerodynamics and propulsive characteristics equivalent to those used in high-fidelity piloted simulation. Databases representative of a modern high-performance aircraft with and without thrust-vectoring capability are included. To simplify the task of developing and implementing maneuvering logics in the TMS, an outer-loop control system known as the Tactical Autopilot (TA) is implemented in the aircraft simulation model. The TA converts guidance commands issued by computerized maneuvering logics in the form of desired angle-of-attack and wind axis-bank angle into inputs to the inner-loop control augmentation system of the aircraft. This report describes the capabilities and operation of the TMS.

NPLOT - NASTRAN PLOT

NASA Technical Reports Server (NTRS)

Mcentire, K.

1994-01-01

NPLOT is an interactive computer graphics program for plotting undeformed and deformed NASTRAN finite element models (FEMs). Although there are many commercial codes already available for plotting FEMs, these have limited use due to their cost, speed, and lack of features to view BAR elements. NPLOT was specifically developed to overcome these limitations. On a vector type graphics device the two best ways to show depth are by hidden line plotting or haloed line plotting. A hidden line algorithm generates views of models with all hidden lines removed, and a haloed line algorithm displays views with aft lines broken in order to show depth while keeping the entire model visible. A haloed line algorithm is especially useful for plotting models composed of many line elements and few surface elements. The most important feature of NPLOT is its ability to create both hidden line and haloed line views accurately and much more quickly than with any other existing hidden or haloed line algorithms. NPLOT is also capable of plotting a normal wire frame view to display all lines of a model. NPLOT is able to aid in viewing all elements, but it has special features not generally available for plotting BAR elements. These features include plotting of TRUE LENGTH and NORMALIZED offset vectors and orientation vectors. Standard display operations such as rotation and perspective are possible, but different view planes such as X-Y, Y-Z, and X-Z may also be selected. Another display option is the Z-axis cut which allows a portion of the fore part of the model to be cut away to reveal details of the inside of the model. A zoom function is available to terminals with a locator (graphics cursor, joystick, etc.). The user interface of NPLOT is designed to make the program quick and easy to use. A combination of menus and commands with help menus for detailed information about each command allows experienced users greater speed and efficiency. Once a plot is on the screen the interface becomes command driven, enabling the user to manipulate the display or execute a command without having to return to the menu. NPLOT is also able to plot deformed shapes allowing it to perform post-processing. The program can read displacements, either static displacements or eigenvectors, from a MSC/NASTRAN F06 file or a UAI/NASTRAN PRT file. The displacements are written into a unformatted scratch file where they are available for rapid access when the user wishes to display a deformed shape. All subcases or mode shapes can be read in at once. Then it is easy to enable the deformed shape, to change subcases or mode shapes and to change the scale factor for subsequent plots. NPLOT is written in VAX FORTRAN for DEC VAX series computers running VMS. As distributed, the NPLOT source code makes calls to the DI3000 graphics package from Precision Visuals; however, a set of interface routines is provided to translate the DI3000 calls into Tektronix PLOT10/TCS graphics library calls so that NPLOT can use the standard Tektronix 4010 which many PC terminal emulation software programs support. NPLOT is available in VAX BACKUP format on a 9-track 1600 BPI DEC VAX BACKUP format magnetic tape (standard media) or a TK50 tape cartridge. This program was developed in 1991. DEC, VAX, VMS, and TK50 are trademarks of Digital Equipment Corporation. Tektronix, PLOT10, and TCS are trademarks of Tektronix, Inc. DI3000 is a registered trademark of Precision Visuals, Inc. NASTRAN is a registered trademark of the National Aeronautics and Space Administration. MSC/ is a trademark of MacNeal-Schwendler Corporation. UAI is a trademark of Universal Analytics, Inc.

Integrating valve-inspired design features into poly(ethylene glycol) hydrogel scaffolds for heart valve tissue engineering.

PubMed

Zhang, Xing; Xu, Bin; Puperi, Daniel S; Yonezawa, Aline L; Wu, Yan; Tseng, Hubert; Cuchiara, Maude L; West, Jennifer L; Grande-Allen, K Jane

2015-03-01

The development of advanced scaffolds that recapitulate the anisotropic mechanical behavior and biological functions of the extracellular matrix in leaflets would be transformative for heart valve tissue engineering. In this study, anisotropic mechanical properties were established in poly(ethylene glycol) (PEG) hydrogels by crosslinking stripes of 3.4 kDa PEG diacrylate (PEGDA) within 20 kDa PEGDA base hydrogels using a photolithographic patterning method. Varying the stripe width and spacing resulted in a tensile elastic modulus parallel to the stripes that was 4.1-6.8 times greater than that in the perpendicular direction, comparable to the degree of anisotropy between the circumferential and radial orientations in native valve leaflets. Biomimetic PEG-peptide hydrogels were prepared by tethering the cell-adhesive peptide RGDS and incorporating the collagenase-degradable peptide PQ (GGGPQG↓IWGQGK) into the polymer network. The specific amounts of RGDS and PEG-PQ within the resulting hydrogels influenced the elongation, de novo extracellular matrix deposition and hydrogel degradation behavior of encapsulated valvular interstitial cells (VICs). In addition, the morphology and activation of VICs grown atop PEG hydrogels could be modulated by controlling the concentration or micro-patterning profile of PEG-RGDS. These results are promising for the fabrication of PEG-based hydrogels using anatomically and biologically inspired scaffold design features for heart valve tissue engineering. Copyright © 2014 Acta Materialia Inc. Published by Elsevier Ltd. All rights reserved.

Effects of climate change on streamflow extremes and implications for reservoir inflow in the United States

DOE PAGES

Naz, Bibi S.; Kao, Shih -Chieh; Ashfaq, Moetasim; ...

2017-11-15

The magnitude and frequency of hydrometeorological extremes are expected to increase in the conterminous United States (CONUS) over the rest of this century, and their increase will significantly impact water resource management. While previous efforts focused on the effects of reservoirs on downstream discharge, the effects of climate change on reservoir inflows in upstream areas are not well understood. We evaluated the large-scale climate change effects on extreme hydrological events and their implications for reservoir inflows in 178 headwater basins across CONUS using the Variable Infiltration Capacity (VIC) hydrologic model. The VIC model was forced with a 10-member ensemble ofmore » global circulation models under the Representative Concentration Pathway 8.5 that were dynamically downscaled using a regional climate model (RegCM4) and bias-corrected to 1/24° grid cell resolution. The results projected an increase in the likelihood of flood risk by 44% for a majority of subbasins upstream of flood control reservoirs in the central United States and increased drought risk by 11% for subbasins upstream of hydropower reservoirs across the western United States. Increased risk of both floods and droughts can potentially make reservoirs across CONUS more vulnerable to future climate conditions. In conclusion, this study estimates reservoir inflow changes over the next several decades, which can be used to optimize water supply management downstream.« less

Effects of climate change on streamflow extremes and implications for reservoir inflow in the United States

DOE Office of Scientific and Technical Information (OSTI.GOV)

Naz, Bibi S.; Kao, Shih -Chieh; Ashfaq, Moetasim

The magnitude and frequency of hydrometeorological extremes are expected to increase in the conterminous United States (CONUS) over the rest of this century, and their increase will significantly impact water resource management. While previous efforts focused on the effects of reservoirs on downstream discharge, the effects of climate change on reservoir inflows in upstream areas are not well understood. We evaluated the large-scale climate change effects on extreme hydrological events and their implications for reservoir inflows in 178 headwater basins across CONUS using the Variable Infiltration Capacity (VIC) hydrologic model. The VIC model was forced with a 10-member ensemble ofmore » global circulation models under the Representative Concentration Pathway 8.5 that were dynamically downscaled using a regional climate model (RegCM4) and bias-corrected to 1/24° grid cell resolution. The results projected an increase in the likelihood of flood risk by 44% for a majority of subbasins upstream of flood control reservoirs in the central United States and increased drought risk by 11% for subbasins upstream of hydropower reservoirs across the western United States. Increased risk of both floods and droughts can potentially make reservoirs across CONUS more vulnerable to future climate conditions. In conclusion, this study estimates reservoir inflow changes over the next several decades, which can be used to optimize water supply management downstream.« less

Reliability Analysis and Standardization of Spacecraft Command Generation Processes

NASA Technical Reports Server (NTRS)

Meshkat, Leila; Grenander, Sven; Evensen, Ken

2011-01-01

center dot In order to reduce commanding errors that are caused by humans, we create an approach and corresponding artifacts for standardizing the command generation process and conducting risk management during the design and assurance of such processes. center dot The literature review conducted during the standardization process revealed that very few atomic level human activities are associated with even a broad set of missions. center dot Applicable human reliability metrics for performing these atomic level tasks are available. center dot The process for building a "Periodic Table" of Command and Control Functions as well as Probabilistic Risk Assessment (PRA) models is demonstrated. center dot The PRA models are executed using data from human reliability data banks. center dot The Periodic Table is related to the PRA models via Fault Links.

One multi-media environmental system with linkage between meteorology/ hydrology/ air quality models and water quality model

NASA Astrophysics Data System (ADS)

Tang, C.; Lynch, J. A.; Dennis, R. L.

2016-12-01

The biogeochemical processing of nitrogen and associated pollutants is driven by meteorological and hydrological processes in conjunction with pollutant loading. There are feedbacks between meteorology and hydrology that will be affected by land-use change and climate change. Changes in meteorology will affect pollutant deposition. It is important to account for those feedbacks and produce internally consistent simulations of meteorology, hydrology, and pollutant loading to drive the (watershed/water quality) biogeochemical models. In this study, the ecological response to emission reductions in streams in the Potomac watershed was evaluated. Firstly, we simulated the deposition by using the fully coupled Weather Research & Forecasting (WRF) model and the Community Multiscale Air Quality (CAMQ) model; secondly, we created the hydrological data by the offline linked Variable Infiltration Capacity (VIC) model and the WRF model. Lastly, we investigated the water quality by one comprehensive/environment model, namely the linkage of CMAQ, WRF, VIC and the Model of Acidification of Groundwater In Catchment (MAGIC) model from 2002 to 2010.The simulated results (such as NO3, SO4, and SBC) fit well to the observed values. The linkage provides a generally accurate, well-tested tool for evaluating sensitivities to varying meteorology and environmental changes on acidification and other biogeochemical processes, with capability to comprehensively explore strategic policy and management design.

Optimal attitude maneuver execution for the Advanced Composition Explorer (ACE) mission

NASA Technical Reports Server (NTRS)

Woodard, Mark A.; Baker, David

1995-01-01

The Advanced Composition Explorer (ACE) spacecraft will require frequent attitude reorientations in order to maintain the spacecraft high gain antenna (HGA) within 3 deg of earth-pointing. These attitude maneuvers will be accomplished by employing a series of ground-commanded thruster pulses, computed by ground operations personnel, to achieve the desired change in the spacecraft angular momentum vector. With each maneuver, attitude nutation will be excited. Large nutation angles are undesirable from a science standpoint. It is important that the thruster firings be phased properly in order to minimize the nutation angle at the end of the maneuver so that science collection time is maximized. The analysis presented derives a simple approximation for the nutation contribution resulting from a series of short thruster burns. Analytic equations are derived which give the induced nutation angle as a function of the number of small thruster burns used to execute the attitude maneuver and the phasing of the burns. The results show that by properly subdividing the attitude burns, the induced nutation can be kept low. The analytic equations are also verified through attitude dynamics simulation and simulation results are presented. Finally, techniques for quantifying the post-maneuver nutation are discussed.

Evaluation of Drought Occurrence and Climate Change in the Pearl River Basin in South China

NASA Astrophysics Data System (ADS)

DU, Y.; Chen, J.; Wang, K.; Shi, H.

2015-12-01

This study uses the Variable Infiltration Capacity (VIC) Model to simulate the hydrological processes over the Pearl River basin in South China. The observed streamflow data in the Pearl River Basin for the period 1951-2000 are used to evaluate the model simulation results. Further, in this study, the 55 datasets of climate projection from 18 General Circulation Models (GCMs) for the IPCC AR4 (SRES A2/A1B/B1) and AR5 (RCP 2.6/4.5/6.0/8.5) are used to drive the VIC model at 0.5°× 0.5°spatial resolution and daily temporal resolution. Then, the monthly Standard Precipitation Index (SPI) and standardized runoff index (SRI) are generated to detect the drought occurrence. This study validates the GCMs projection through comparing the observed precipitation for the period of 2000-2013. Then, spatial variation of the frequency change of moderate drought, severe drought and extreme drought are analyzed for the 21st century. The study reveals that the frequencies of severe drought and extreme drought occurrences over the Pearl River Basin increase along with time. Specifically, for the scenario of AR5 RCP 8.5, the east and west parts of the Pearl River Basin most likely suffer from severe drought and extreme drought with an increased frequency throughout the 21st century.

Sensitivity of Hydrologic Extremes to Spatial Resolution of Meteorological Forcings: A Case Study of the Conterminous United States

NASA Astrophysics Data System (ADS)

Kao, S. C.; Naz, B. S.; Gangrade, S.; Ashfaq, M.; Rastogi, D.

2016-12-01

The magnitude and frequency of hydroclimate extremes are projected to increase in the conterminous United States (CONUS) with significant implications for future water resource planning and flood risk management. Nevertheless, apart from the change of natural environment, the choice of model spatial resolution could also artificially influence the features of simulated extremes. To better understand how the spatial resolution of meteorological forcings may affect hydroclimate projections, we test the runoff sensitivity using the Variable Infiltration Capacity (VIC) model that was calibrated for each CONUS 8-digit hydrologic unit (HUC8) at 1/24° ( 4km) grid resolution. The 1980-2012 gridded Daymet and PRISM meteorological observations are used to conduct the 1/24° resolution control simulation. Comparative simulations are achieved by smoothing the 1/24° forcing into 1/12° and 1/8° resolutions which are then used to drive the VIC model for the CONUS. In addition, we also test how the simulated high and low runoff conditions would react to change in precipitation (±10%) and temperature (+1°C). The results are further analyzed for various types of hydroclimate extremes across different watersheds in the CONUS. This work helps us understand the sensitivity of simulated runoff to different spatial resolutions of climate forcings and also its sensitivity to different watershed sizes and characteristics of extreme events in the future climate conditions.

Analysis of Humanitarian Assistance Cargo Transportation

DTIC Science & Technology

2012-06-01

deliver materiel to people in need in their areas of responsibility. This report analyzes the options available to these commands in seeking...Thus, United States combatant commands increasingly rely on humanitarian assistance cargo transportation programs to deliver material to people in need...United States Navy and Marine Corps personnel and people overseas. PH may also arrange for space-available transportation of NGO material to consigned

Study of Synthetic Vision Systems (SVS) and Velocity-vector Based Command Augmentation System (V-CAS) on Pilot Performance

NASA Technical Reports Server (NTRS)

Liu, Dahai; Goodrich, Ken; Peak, Bob

2006-01-01

This study investigated the effects of synthetic vision system (SVS) concepts and advanced flight controls on single pilot performance (SPP). Specifically, we evaluated the benefits and interactions of two levels of terrain portrayal, guidance symbology, and control-system response type on SPP in the context of lower-landing minima (LLM) approaches. Performance measures consisted of flight technical error (FTE) and pilot perceived workload. In this study, pilot rating, control type, and guidance symbology were not found to significantly affect FTE or workload. It is likely that transfer from prior experience, limited scope of the evaluation task, specific implementation limitations, and limited sample size were major factors in obtaining these results.

One-dimensional filtration of pharmaceutical grade phyllosilicate dispersions.

PubMed

Viseras, C; Cerezo, P; Meeten, G H; Lopez-Galindo, A

2001-04-17

The filtration behaviour of some clay-water dispersions was studied. Two Spanish fibrous phyllosilicates (sepiolite from Vicálvaro and palygorskite from Turón) and a commercial bentonite (Bentopharm UK) with similar sizes and different morphologies (fibrous and/or laminar) were selected as model clays. Sepiolite from Vicálvaro is an almost pure fibrous sample, Bentopharm presents a high amount of laminar particles and palygorskite from Turón is made up of similar percentages of laminar and fibrous particles. The disperse systems were made up using a rotor-stator mixer working at two different mixing rates (1000 and 8000 rpm), for periods of 1 and 10 min. Filtration measurements were taken and the corresponding filtration curves obtained. Finally, the desorptivity (S) of the filtration cakes was calculated and correlated to the textural characteristics of the materials, the solid fraction and mixing conditions. Filtration behaviour of the dispersions depended on all three of these factors. Laminar dispersions presented lower S values than fibrous dispersions. In the 2% w/v dispersions the bridging forces between particles did not permit formation of an interconnected network as in 10% w/v dispersions and, consequently, filtration times increased with the solid fraction (i.e. S values decreased). Regarding stability to pH changes, the results showed that filtration behaviour was highly sensitive to basic pH in the fibrous clay dispersions and almost insensitive in the laminar clay dispersions.

A simple hydrologically based model of land surface water and energy fluxes for general circulation models

NASA Technical Reports Server (NTRS)

Liang, XU; Lettenmaier, Dennis P.; Wood, Eric F.; Burges, Stephen J.

1994-01-01

A generalization of the single soil layer variable infiltration capacity (VIC) land surface hydrological model previously implemented in the Geophysical Fluid Dynamics Laboratory (GFDL) general circulation model (GCM) is described. The new model is comprised of a two-layer characterization of the soil column, and uses an aerodynamic representation of the latent and sensible heat fluxes at the land surface. The infiltration algorithm for the upper layer is essentially the same as for the single layer VIC model, while the lower layer drainage formulation is of the form previously implemented in the Max-Planck-Institut GCM. The model partitions the area of interest (e.g., grid cell) into multiple land surface cover types; for each land cover type the fraction of roots in the upper and lower zone is specified. Evapotranspiration consists of three components: canopy evaporation, evaporation from bare soils, and transpiration, which is represented using a canopy and architectural resistance formulation. Once the latent heat flux has been computed, the surface energy balance is iterated to solve for the land surface temperature at each time step. The model was tested using long-term hydrologic and climatological data for Kings Creek, Kansas to estimate and validate the hydrological parameters, and surface flux data from three First International Satellite Land Surface Climatology Project Field Experiment (FIFE) intensive field campaigns in the summer-fall of 1987 to validate the surface energy fluxes.

Design, Optimization, and Evaluation of Integrally-Stiffened Al-2139 Panel with Curved Stiffeners

NASA Technical Reports Server (NTRS)

Havens, David; Shiyekar, Sandeep; Norris, Ashley; Bird, R. Keith; Kapania, Rakesh K.; Olliffe, Robert

2011-01-01

A curvilinear stiffened panel was designed, manufactured, and tested in the Combined Load Test Fixture at NASA Langley Research Center. The panel is representative of a large wing engine pylon rib and was optimized for minimum mass subjected to three combined load cases. The optimization included constraints on web buckling, material yielding, crippling or local stiffener failure, and damage tolerance using a new analysis tool named EBF3PanelOpt. Testing was performed for the critical combined compression-shear loading configuration. The panel was loaded beyond initial buckling, and strains and out-of-plane displacements were extracted from a total of 20 strain gages and 6 linear variable displacement transducers. The VIC-3D system was utilized to obtain full field displacements/strains in the stiffened side of the panel. The experimental data were compared with the strains and out-of-plane deflections from a high fidelity nonlinear finite element analysis. The experimental data were also compared with linear elastic finite element results of the panel/test-fixture assembly. Overall, the panel buckled very near to the predicted load in the web regions.

Normalized Index of Synergy for Evaluating the Coordination of Motor Commands

PubMed Central

Togo, Shunta; Imamizu, Hiroshi

2015-01-01

Humans perform various motor tasks by coordinating the redundant motor elements in their bodies. The coordination of motor outputs is produced by motor commands, as well properties of the musculoskeletal system. The aim of this study was to dissociate the coordination of motor commands from motor outputs. First, we conducted simulation experiments where the total elbow torque was generated by a model of a simple human right and left elbow with redundant muscles. The results demonstrated that muscle tension with signal-dependent noise formed a coordinated structure of trial-to-trial variability of muscle tension. Therefore, the removal of signal-dependent noise effects was required to evaluate the coordination of motor commands. We proposed a method to evaluate the coordination of motor commands, which removed signal-dependent noise from the measured variability of muscle tension. We used uncontrolled manifold analysis to calculate a normalized index of synergy. Simulation experiments confirmed that the proposed method could appropriately represent the coordinated structure of the variability of motor commands. We also conducted experiments in which subjects performed the same task as in the simulation experiments. The normalized index of synergy revealed that the subjects coordinated their motor commands to achieve the task. Finally, the normalized index of synergy was applied to a motor learning task to determine the utility of the proposed method. We hypothesized that a large part of the change in the coordination of motor outputs through learning was because of changes in motor commands. In a motor learning task, subjects tracked a target trajectory of the total torque. The change in the coordination of muscle tension through learning was dominated by that of motor commands, which supported the hypothesis. We conclude that the normalized index of synergy can be used to evaluate the coordination of motor commands independently from the properties of the musculoskeletal system. PMID:26474043

A Computerized Wear Particle Atlas for Ferrogram and Filtergram Analyses

DTIC Science & Technology

1998-01-01

A Computerised Wear Particle Atlas for Ferrogram and Filtergram Analyses Jian G. Ding Lubrosoft P/L P 0 Box 2368, Rowville Melbourne VIC 3178...Australia (61-3) 9759-9083 Abstract: A new computerised wear particle atlas has been developed for identification of solid particles and...differentiation of wear severity of lubricated equipment. This atlas contains 892 images of representative solid particles selected from thousands of filtergram

Managing the resilience space of the German energy system - A vector analysis.

PubMed

Schlör, Holger; Venghaus, Sandra; Märker, Carolin; Hake, Jürgen-Friedrich

2018-07-15

The UN Sustainable Development Goals formulated in 2016 confirmed the sustainability concept of the Earth Summit of 1992 and supported UNEP's green economy transition concept. The transformation of the energy system (Energiewende) is the keystone of Germany's sustainability strategy and of the German green economy concept. We use ten updated energy-related indicators of the German sustainability strategy to analyse the German energy system. The development of the sustainable indicators is examined in the monitoring process by a vector analysis performed in two-dimensional Euclidean space (Euclidean plane). The aim of the novel vector analysis is to measure the current status of the Energiewende in Germany and thereby provide decision makers with information about the strains for the specific remaining pathway of the single indicators and of the total system in order to meet the sustainability targets of the Energiewende. Within this vector model, three vectors (the normative sustainable development vector, the real development vector, and the green economy vector) define the resilience space of our analysis. The resilience space encloses a number of vectors representing different pathways with different technological and socio-economic strains to achieve a sustainable development of the green economy. In this space, the decision will be made as to whether the government measures will lead to a resilient energy system or whether a readjustment of indicator targets or political measures is necessary. The vector analysis enables us to analyse both the government's ambitiousness, which is expressed in the sustainability target for the indicators at the start of the sustainability strategy representing the starting preference order of the German government (SPO) and, secondly, the current preference order of German society in order to bridge the remaining distance to reach the specific sustainability goals of the strategy summarized in the current preference order (CPO). Copyright © 2018 Elsevier Ltd. All rights reserved.

Vector analysis of postcardiotomy behavioral phenomena.

PubMed

Caston, J C; Miller, W C; Felber, W J

1975-04-01

The classification of postcardiotomy behavioral phenomena in Figure 1 is proposed for use as a clinical instrument to analyze etiological determinants. The utilization of a vector analysis analogy inherently denies absolutism. Classifications A-P are presented as prototypes of certain ratio imbalances of the metabolic, hemodynamic, environmental, and psychic vectors. Such a system allows for change from one type to another according to the individuality of the patient and the highly specific changes in his clinical presentation. A vector analysis also allows for infinite intermediary ratio imbalances between classification types as a function of time. Thus, postcardiotomy behavioral phenomena could be viewed as the vector summation of hemodynamic, metabolic, environmental, and psychic processes at a given point in time. Elaboration of unknown determinants in this complex syndrome appears to be task for the future.

The Command & Control of Aggregated Marine Expeditionary Units. Is Anyone Available Today?

DTIC Science & Technology

2013-04-11

Operations. 24 April 2012. https://ehqmc.usmc.mil/org/ ppo /pl/pln. 2. Personal correspondence or phone interviews with each command listed...and Operations. 24 April 2012. https://ehqmc.usmc.mil/org/ ppo /pl/pln. Stover 53 Congressional Budget Office. A CBO Study: An Analysis of the

A spiking neural network model of the midbrain superior colliculus that generates saccadic motor commands.

PubMed

Kasap, Bahadir; van Opstal, A John

2017-08-01

Single-unit recordings suggest that the midbrain superior colliculus (SC) acts as an optimal controller for saccadic gaze shifts. The SC is proposed to be the site within the visuomotor system where the nonlinear spatial-to-temporal transformation is carried out: the population encodes the intended saccade vector by its location in the motor map (spatial), and its trajectory and velocity by the distribution of firing rates (temporal). The neurons' burst profiles vary systematically with their anatomical positions and intended saccade vectors, to account for the nonlinear main-sequence kinematics of saccades. Yet, the underlying collicular mechanisms that could result in these firing patterns are inaccessible to current neurobiological techniques. Here, we propose a simple spiking neural network model that reproduces the spike trains of saccade-related cells in the intermediate and deep SC layers during saccades. The model assumes that SC neurons have distinct biophysical properties for spike generation that depend on their anatomical position in combination with a center-surround lateral connectivity. Both factors are needed to account for the observed firing patterns. Our model offers a basis for neuronal algorithms for spatiotemporal transformations and bio-inspired optimal controllers.

Landscape Visualisation on the Internet

NASA Astrophysics Data System (ADS)

Imhof, M. P.; Cox, M. T.; Harvey, D. W.; Heemskerk, G. E.; Pettit, C. J.

2012-07-01

The Victorian Resources Online (VRO) website (http://www.dpi.vic.gov.au/vro) is the principal means for accessing landscapebased information in Victoria. In this paper we introduce a range of online landscape visualisations that have been developed to enhance existing static web content around the nature and distribution of Victoria's landforms and soils as well as associated processes. Flash is used to develop online visualisations that include interactive landscape panoramas, animations of soil and landscape processes and videos of experts explaining features in the field as well as landscape "flyovers". The use of interactive visualisations adds rich information multimedia content to otherwise static pages and offers the potential to improve user's appreciation and understanding of soil and landscapes. Visualisation is becoming a key component of knowledge management activities associated with VRO - proving useful for both "knowledge capture" (from subject matter specialists) and "knowledge transfer" to a diverse user base. A range of useful visualisation products have been made available online, with varying degrees of interactivity and suited to a variety of users. The use of video files, animation and interactive visualisations is adding rich information content to otherwise static web pages. These information products offer new possibilities to enhance learning of landscapes and the effectiveness of these will be tested as the next phase of development.

The Newick utilities: high-throughput phylogenetic tree processing in the Unix shell

PubMed Central

Junier, Thomas; Zdobnov, Evgeny M.

2010-01-01

Summary: We present a suite of Unix shell programs for processing any number of phylogenetic trees of any size. They perform frequently-used tree operations without requiring user interaction. They also allow tree drawing as scalable vector graphics (SVG), suitable for high-quality presentations and further editing, and as ASCII graphics for command-line inspection. As an example we include an implementation of bootscanning, a procedure for finding recombination breakpoints in viral genomes. Availability: C source code, Python bindings and executables for various platforms are available from http://cegg.unige.ch/newick_utils. The distribution includes a manual and example data. The package is distributed under the BSD License. Contact: thomas.junier@unige.ch PMID:20472542

Process for structural geologic analysis of topography and point data

DOEpatents

Eliason, Jay R.; Eliason, Valerie L. C.

1987-01-01

A quantitative method of geologic structural analysis of digital terrain data is described for implementation on a computer. Assuming selected valley segments are controlled by the underlying geologic structure, topographic lows in the terrain data, defining valley bottoms, are detected, filtered and accumulated into a series line segments defining contiguous valleys. The line segments are then vectorized to produce vector segments, defining valley segments, which may be indicative of the underlying geologic structure. Coplanar analysis is performed on vector segment pairs to determine which vectors produce planes which represent underlying geologic structure. Point data such as fracture phenomena which can be related to fracture planes in 3-dimensional space can be analyzed to define common plane orientation and locations. The vectors, points, and planes are displayed in various formats for interpretation.

Flight Dynamics Aspects of a Large Civil Tiltrotor Simulation Using Translational Rate Command

NASA Technical Reports Server (NTRS)

Lawrence, Ben; Malpica, Carlos A.; Theodore, Colin R.; Decker, William A.; Lindsey, James E.

2011-01-01

An in-depth analysis of a Large Civil Tiltrotor simulation with a Translational Rate Command control law that uses automatic nacelle deflections for longitudinal velocity control and lateral cyclic for lateral velocity control is presented. Results from piloted real-time simulation experiments and offline time and frequency domain analyses are used to investigate the fundamental flight dynamic and control mechanisms of the control law. The baseline Translational Rate Command conferred handling qualities improvements over an attitude command attitude hold control law but in some scenarios there was a tendency to enter PIO. Nacelle actuator rate limiting strongly influenced the PIO tendency and reducing the rate limits degraded the handling qualities further. Counterintuitively, increasing rate limits also led to a worsening of the handling qualities ratings. This led to the identification of a nacelle rate to rotor longitudinal flapping coupling effect that induced undesired pitching motions proportional to the allowable amount of nacelle rate. A modification that applied a counteracting amount of longitudinal cyclic proportional to the nacelle rate significantly improved the handling qualities. The lateral axis of the Translational Rate Command conferred Level 1 handling qualities in a Lateral Reposition maneuver. Analysis of the influence of the modeling fidelity on the lateral flapping angles is presented. It is showed that the linear modeling approximation is likely to have under-predicted the side-force and therefore under-predicted the lateral flapping at velocities above 15 ft/s. However, at lower velocities, and therefore more weakly influenced by the side force modeling, the accelerations that the control law commands also significantly influenced the peak levels of lateral flapping achieved.

Linking Time and Space Scales in Distributed Hydrological Modelling - a case study for the VIC model

NASA Astrophysics Data System (ADS)

Melsen, Lieke; Teuling, Adriaan; Torfs, Paul; Zappa, Massimiliano; Mizukami, Naoki; Clark, Martyn; Uijlenhoet, Remko

2015-04-01

One of the famous paradoxes of the Greek philosopher Zeno of Elea (~450 BC) is the one with the arrow: If one shoots an arrow, and cuts its motion into such small time steps that at every step the arrow is standing still, the arrow is motionless, because a concatenation of non-moving parts does not create motion. Nowadays, this reasoning can be refuted easily, because we know that motion is a change in space over time, which thus by definition depends on both time and space. If one disregards time by cutting it into infinite small steps, motion is also excluded. This example shows that time and space are linked and therefore hard to evaluate separately. As hydrologists we want to understand and predict the motion of water, which means we have to look both in space and in time. In hydrological models we can account for space by using spatially explicit models. With increasing computational power and increased data availability from e.g. satellites, it has become easier to apply models at a higher spatial resolution. Increasing the resolution of hydrological models is also labelled as one of the 'Grand Challenges' in hydrology by Wood et al. (2011) and Bierkens et al. (2014), who call for global modelling at hyperresolution (~1 km and smaller). A literature survey on 242 peer-viewed articles in which the Variable Infiltration Capacity (VIC) model was used, showed that the spatial resolution at which the model is applied has decreased over the past 17 years: From 0.5 to 2 degrees when the model was just developed, to 1/8 and even 1/32 degree nowadays. On the other hand the literature survey showed that the time step at which the model is calibrated and/or validated remained the same over the last 17 years; mainly daily or monthly. Klemeš (1983) stresses the fact that space and time scales are connected, and therefore downscaling the spatial scale would also imply downscaling of the temporal scale. Is it worth the effort of downscaling your model from 1 degree to 1/24 degree, if in the end you only look at monthly runoff? In this study an attempt is made to link time and space scales in the VIC model, to study the added value of a higher spatial resolution-model for different time steps. In order to do this, four different VIC models were constructed for the Thur basin in North-Eastern Switzerland (1700 km²), a tributary of the Rhine: one lumped model, and three spatially distributed models with a resolution of respectively 1x1 km, 5x5 km, and 10x10 km. All models are run at an hourly time step and aggregated and calibrated for different time steps (hourly, daily, monthly, yearly) using a novel Hierarchical Latin Hypercube Sampling Technique (Vořechovský, 2014). For each time and space scale, several diagnostics like Nash-Sutcliffe efficiency, Kling-Gupta efficiency, all the quantiles of the discharge etc., are calculated in order to compare model performance over different time and space scales for extreme events like floods and droughts. Next to that, the effect of time and space scale on the parameter distribution can be studied. In the end we hope to find a link for optimal time and space scale combinations.

Simple proteomics data analysis in the object-oriented PowerShell.

PubMed

Mohammed, Yassene; Palmblad, Magnus

2013-01-01

Scripting languages such as Perl and Python are appreciated for solving simple, everyday tasks in bioinformatics. A more recent, object-oriented command shell and scripting language, Windows PowerShell, has many attractive features: an object-oriented interactive command line, fluent navigation and manipulation of XML files, ability to consume Web services from the command line, consistent syntax and grammar, rich regular expressions, and advanced output formatting. The key difference between classical command shells and scripting languages, such as bash, and object-oriented ones, such as PowerShell, is that in the latter the result of a command is a structured object with inherited properties and methods rather than a simple stream of characters. Conveniently, PowerShell is included in all new releases of Microsoft Windows and therefore already installed on most computers in classrooms and teaching labs. In this chapter we demonstrate how PowerShell in particular allows easy interaction with mass spectrometry data in XML formats, connection to Web services for tools such as BLAST, and presentation of results as formatted text or graphics. These features make PowerShell much more than "yet another scripting language."

Decrease in medical command errors with use of a "standing orders" protocol system.

PubMed

Holliman, C J; Wuerz, R C; Meador, S A

1994-05-01

The purpose of this study was to determine the physician medical command error rates and paramedic error rates after implementation of a "standing orders" protocol system for medical command. These patient-care error rates were compared with the previously reported rates for a "required call-in" medical command system (Ann Emerg Med 1992; 21(4):347-350). A secondary aim of the study was to determine if the on-scene time interval was increased by the standing orders system. Prospectively conducted audit of prehospital advanced life support (ALS) trip sheets was made at an urban ALS paramedic service with on-line physician medical command from three local hospitals. All ALS run sheets from the start time of the standing orders system (April 1, 1991) for a 1-year period ending on March 30, 1992 were reviewed as part of an ongoing quality assurance program. Cases were identified as nonjustifiably deviating from regional emergency medical services (EMS) protocols as judged by agreement of three physician reviewers (the same methodology as a previously reported command error study in the same ALS system). Medical command and paramedic errors were identified from the prehospital ALS run sheets and categorized. Two thousand one ALS runs were reviewed; 24 physician errors (1.2% of the 1,928 "command" runs) and eight paramedic errors (0.4% of runs) were identified. The physician error rate was decreased from the 2.6% rate in the previous study (P < .0001 by chi 2 analysis). The on-scene time interval did not increase with the "standing orders" system.(ABSTRACT TRUNCATED AT 250 WORDS)

The Cross Product of Two Vectors Is Not Just Another Vector--A Major Misconception Being Perpetuated in Calculus and Vector Analysis Textbooks.

ERIC Educational Resources Information Center

Elk, Seymour B.

1997-01-01

Suggests that the cross product of two vectors can be more easily and accurately explained by starting from the perspective of dyadics because then the concept of vector multiplication has a simple geometrical picture that encompasses both the dot and cross products in any number of dimensions in terms of orthogonal unit vector components. (AIM)

Pattern Recognition Control Design

NASA Technical Reports Server (NTRS)

Gambone, Elisabeth A.

2018-01-01

Spacecraft control algorithms must know the expected vehicle response to any command to the available control effectors, such as reaction thrusters or torque devices. Spacecraft control system design approaches have traditionally relied on the estimated vehicle mass properties to determine the desired force and moment, as well as knowledge of the effector performance to efficiently control the spacecraft. A pattern recognition approach was used to investigate the relationship between the control effector commands and spacecraft responses. Instead of supplying the approximated vehicle properties and the thruster performance characteristics, a database of information relating the thruster ring commands and the desired vehicle response was used for closed-loop control. A Monte Carlo simulation data set of the spacecraft dynamic response to effector commands was analyzed to establish the influence a command has on the behavior of the spacecraft. A tool developed at NASA Johnson Space Center to analyze flight dynamics Monte Carlo data sets through pattern recognition methods was used to perform this analysis. Once a comprehensive data set relating spacecraft responses with commands was established, it was used in place of traditional control methods and gains set. This pattern recognition approach was compared with traditional control algorithms to determine the potential benefits and uses.

Cognitive Systems Modeling and Analysis of Command and Control Systems

NASA Technical Reports Server (NTRS)

Norlander, Arne

2012-01-01

Military operations, counter-terrorism operations and emergency response often oblige operators and commanders to operate within distributed organizations and systems for safe and effective mission accomplishment. Tactical commanders and operators frequently encounter violent threats and critical demands on cognitive capacity and reaction time. In the future they will make decisions in situations where operational and system characteristics are highly dynamic and non-linear, i.e. minor events, decisions or actions may have serious and irreversible consequences for the entire mission. Commanders and other decision makers must manage true real time properties at all levels; individual operators, stand-alone technical systems, higher-order integrated human-machine systems and joint operations forces alike. Coping with these conditions in performance assessment, system development and operational testing is a challenge for both practitioners and researchers. This paper reports on research from which the results led to a breakthrough: An integrated approach to information-centered systems analysis to support future command and control systems research development. This approach integrates several areas of research into a coherent framework, Action Control Theory (ACT). It comprises measurement techniques and methodological advances that facilitate a more accurate and deeper understanding of the operational environment, its agents, actors and effectors, generating new and updated models. This in turn generates theoretical advances. Some good examples of successful approaches are found in the research areas of cognitive systems engineering, systems theory, and psychophysiology, and in the fields of dynamic, distributed decision making and naturalistic decision making.

Intelligence and Electronic Warfare (IEW) Streamlining Project. Volume 3. Reference Documentation (Part 3)

DTIC Science & Technology

1992-09-01

APPENDIX Al : INSCOM Lessons Learned III~l A kpxffrI Strategic Logistics Agency Paper, undated, Suff.’ Integrated Sustabinent Mainteanceo Concept...credit for billions ofd(10- lars ol s;ving-s fromi streasnlimiaci,, .CiVIcs 111,1 have Concept ror Integrated Skislamimgscnt Al |iiimcnsaisce enput in...TMDFE is These recommcndations would he made by thc an existing model for how the Single Manager ISMM to assure that Reserve and National Guard concept

Investigation of Microwave Monolithic Integrated Circuit (MMIC) Non-Reciprocal Millimeterwave Components

DTIC Science & Technology

1991-09-01

nickel zinc ferrite films and (2) sputtering of barium hexaferrites with C-axis oriented normally to the film plane. The SSP tech- nique potential for...M-Wave, Components, Ferrites, Films , Yig, Nickel, Zinc , Hexagonal, R96E Measurements, Frequency, Magnetic, Barium Ferrite 17. SECURITY CLASSIFICATION...techniques to integrate millimeter-wave ferrite devices with GaAs VI&Cs. APPROACH Our approach was to deposit ferrite thin films on GaAs sub- strates in a

On the Value of Climate Elasticity Indices to Assess the Impact of Climate Change on Streamflow Projection using an ensemble of bias corrected CMIP5 dataset

NASA Astrophysics Data System (ADS)

Demirel, Mehmet; Moradkhani, Hamid

2015-04-01

Changes in two climate elasticity indices, i.e. temperature and precipitation elasticity of streamflow, were investigated using an ensemble of bias corrected CMIP5 dataset as forcing to two hydrologic models. The Variable Infiltration Capacity (VIC) and the Sacramento Soil Moisture Accounting (SAC-SMA) hydrologic models, were calibrated at 1/16 degree resolution and the simulated streamflow was routed to the basin outlet of interest. We estimated precipitation and temperature elasticity of streamflow from: (1) observed streamflow; (2) simulated streamflow by VIC and SAC-SMA models using observed climate for the current climate (1963-2003); (3) simulated streamflow using simulated climate from 10 GCM - CMIP5 dataset for the future climate (2010-2099) including two concentration pathways (RCP4.5 and RCP8.5) and two downscaled climate products (BCSD and MACA). The streamflow sensitivity to long-term (e.g., 30-year) average annual changes in temperature and precipitation is estimated for three periods i.e. 2010-40, 2040-70 and 2070-99. We compared the results of the three cases to reflect on the value of precipitation and temperature indices to assess the climate change impacts on Columbia River streamflow. Moreover, these three cases for two models are used to assess the effects of different uncertainty sources (model forcing, model structure and different pathways) on the two climate elasticity indices.

Vector magnetometer design study: Analysis of a triaxial fluxgate sensor design demonstrates that all MAGSAT Vector Magnetometer specifications can be met

NASA Technical Reports Server (NTRS)

Adams, D. F.; Hartmann, U. G.; Lazarow, L. L.; Maloy, J. O.; Mohler, G. W.

1976-01-01

The design of the vector magnetometer selected for analysis is capable of exceeding the required accuracy of 5 gamma per vector field component. The principal elements that assure this performance level are very low power dissipation triaxial feedback coils surrounding ring core flux-gates and temperature control of the critical components of two-loop feedback electronics. An analysis of the calibration problem points to the need for improved test facilities.

Challenging assumptions of notational transparency: the case of vectors in engineering mathematics

NASA Astrophysics Data System (ADS)

Craig, Tracy S.

2017-11-01

The notation for vector analysis has a contentious nineteenth century history, with many different notations describing the same or similar concepts competing for use. While the twentieth century has seen a great deal of unification in vector analysis notation, variation still remains. In this paper, the two primary notations used for expressing the components of a vector are discussed in historical and current context. Popular mathematical texts use the two notations as if they are transparent and interchangeable. In this research project, engineering students' proficiency at vector analysis was assessed and the data were analyzed using the Rasch measurement method. Results indicate that the students found items expressed in unit vector notation more difficult than those expressed in parenthesis notation. The expert experience of notation as transparent and unproblematically symbolic of underlying processes independent of notation is shown to contrast with the student experience where the less familiar notation is experienced as harder to work with.

Applications of instructional design theory to lesson planning for Superfund incident commander training

DOE Office of Scientific and Technical Information (OSTI.GOV)

Mansfield, N.J.

1992-01-01

The increasing number of hazardous materials accidents in the United States has resulted in new federal regulations addressing the emergency response activities associated with chemical releases. A significant part of these new federal standards (29 CFR 1910.120 and 40 CFR Part 311) requires compliance with specific criteria by all personnel involved in a hazardous material emergency. This study investigated alternative lesson design models applicable to instruction for hazardous material emergencies. A specialized design checklist was created based on the work of Gagne, Briggs, and Wager (1988), Merrill (1987), and Clark (1989). This checklist was used in the development of lessonmore » plan templates for the hazardous materials incident commander course. Qualitative data for establishing learning objectives was collected by conducting a needs assessment and a job analysis of the incident commander position. Incident commanders from 14 public and private organizations participated in the needs assessment process. Technical information for the lessons was collected from appropriate governmental agencies. The implementation of the checklist and lesson plans can contribute to assuring quality training for incident commanders throughout the United States.« less

A Search for Vector Magnetic Field Variations Associated with the M-Class Flares of 1991 June 10 in AR 6659

NASA Technical Reports Server (NTRS)

Hagyard, Mona J.; Stark, B. A.; Venkatakrishnan, P.

1998-01-01

A careful analysis of a 6-hour time sequence of vector magnetograms of AR 6659, observed on 1991 June 10 with the MSFC vector magnetograph, has revealed only minor changes in the vector magnetic field azimuths in the vicinity of two M-class flares, and the association of these changes with the flares is not unambiguous. In this paper we present our analysis of the data which includes comparison of vector magnetograms prior to and during the flares, calculation of distributions of the rms variation of the azimuth at each pixel in the field of view of the active region, and examination of the variation with time of the azimuths at every pixel covered by the main flare emissions as observed with the H-alpha telescope coaligned with the vector magnetograph. We also present results of an analysis of evolutionary changes in the azimuth over the field of view of the active region.

Recent Selected Papers of Northwestern Polytechnical University in Two Parts, Part II.

DTIC Science & Technology

1981-08-28

OF CONTENTS Page Dual Properties of Elastic Structures 1 Matrix Analysis of Wings 76 On a Method for the Determination of Plane Stress Fracture...I= Ea]{(x, v,z) j l~i l’m mini The equation above means that the cisplacement function vector determines the strain function vector. (Assumption II...means that the distributed load function vector is determined by the stress function vector. In Section 1, there was an analysis of a three

pyNSMC: A Python Module for Null-Space Monte Carlo Uncertainty Analysis

NASA Astrophysics Data System (ADS)

White, J.; Brakefield, L. K.

2015-12-01

The null-space monte carlo technique is a non-linear uncertainty analyses technique that is well-suited to high-dimensional inverse problems. While the technique is powerful, the existing workflow for completing null-space monte carlo is cumbersome, requiring the use of multiple commandline utilities, several sets of intermediate files and even a text editor. pyNSMC is an open-source python module that automates the workflow of null-space monte carlo uncertainty analyses. The module is fully compatible with the PEST and PEST++ software suites and leverages existing functionality of pyEMU, a python framework for linear-based uncertainty analyses. pyNSMC greatly simplifies the existing workflow for null-space monte carlo by taking advantage of object oriented design facilities in python. The core of pyNSMC is the ensemble class, which draws and stores realized random vectors and also provides functionality for exporting and visualizing results. By relieving users of the tedium associated with file handling and command line utility execution, pyNSMC instead focuses the user on the important steps and assumptions of null-space monte carlo analysis. Furthermore, pyNSMC facilitates learning through flow charts and results visualization, which are available at many points in the algorithm. The ease-of-use of the pyNSMC workflow is compared to the existing workflow for null-space monte carlo for a synthetic groundwater model with hundreds of estimable parameters.

Sovereignty and Collaboration: Affordable Strategies in Times of Austerity

DTIC Science & Technology

2016-10-01

provide precision-guided bombs and a land-support SOVEREIGNTY—ANALYSIS 26 vehicle were delivered for more than 20 percent below the expenditure ini...weapon Precision-guided bomb Support vehicle Panther command & control vehicle Successor Identification Friend or Foe (IFF) Joint combat aircraft...GLMRS) Multi-role armoured vehicle (MRAV) Next-generation light anti-armoured weapon Precision-guided bomb Support vehicle Panther command & control

Training Effectiveness and Cost Iterative Technique (TECIT). Volume 2. Cost Effectiveness Analysis

DTIC Science & Technology

1988-07-01

Moving Tank in a Field Exercise A The task cluster identified as tank commander’s station/tank gunnery and the sub-task of firing an M250 grenade launcher...Firing Procedures, Task Number 171-126-1028. I OBJECTIVE: Given an Ml tank with crew, loaded M250 I grenade launcher, the commander’s station powered up

Navigator Command Potential: An Analysis of U.S. Air Force Pilot Attitudes toward the Job Satisfaction Characteristics of U.S. Air Force Navigators

DTIC Science & Technology

1990-09-01

than many of the other officer career fields. In 1986, Marchewka reported that job dissatisfaction among navigators was *probably because their jobs are...Company, Inc., 1935. 30. Marchewka , Maj Peter S. Job Attitudes of USAF Pilots and Navigators. Unpublished report No. 86-1610. Air Command and Staff

A CONTENT ANALYSIS OF MILITARY COMMANDER MESSAGES ABOUT TOBACCO AND OTHER HEALTH ISSUES IN MILITARY INSTALLATION NEWSPAPERS: WHAT DO MILITARY COMMANDERS SAY ABOUT TOBACCO?

PubMed Central

Poston, Walker S.C.; Haddock, Christopher K.; Jahnke, Sara A.; Hyder, Melissa L.; Jitnarin, Nattinee

2014-01-01

Military installation newspapers are a primary means used by military commanders to communicate information about topics important to military personnel including leadership, training issues, installation events, safety concerns, and vital health issues. We conducted a content analysis of military commanders’ messages about health issues that were published in online military installation newspapers/newsfeeds. We identified a total of 75 publicly accessible installation newspapers/newsfeeds with commanders’ messages (n=39 Air Force, n=19 Army, n=7 Navy, n=1 Marine, and n=9 Joint Bases). Commander messages published between January 2012–December 2012 were collected, screened, and coded. Coder inter-rater reliability was 98.9%. Among the 2,479 coded commanders’ messages, 132 (5.3%) addressed a health topic as the primary focus. There were no significant differences between service branches in the percentage of health-oriented messages (χ2=5.019, p=0.285). The most commonly addressed health topics were exercise/fitness (23.5%), other mental health concerns (19.7%), alcohol/DUI (13.6%), and suicide (12.1%). Tobacco use was directly addressed as a primary health aim in only two commanders’ messages (1.5%). Health topics, and particularly tobacco-related content, are rarely written about by military commanders. The absence of tobacco-related health messages from line leadership contributes to the perception that tobacco control is a low priority. PMID:26032388

Curriculum Evolution at Air Command and Staff College in the Post-Cold War Era

ERIC Educational Resources Information Center

Donovan, William Robert, II.

2010-01-01

This qualitative study used a historical research method to eliminate the gap in the historical knowledge of Air Command and Staff College (ACSC) curriculum evolution in the post-Cold War era. This study is the only known analysis of the forces that influenced the ACSC curriculum and the rationale behind curricular change at ACSC in the post-Cold…

Thermally-Constrained Fuel-Optimal ISS Maneuvers

NASA Technical Reports Server (NTRS)

Bhatt, Sagar; Svecz, Andrew; Alaniz, Abran; Jang, Jiann-Woei; Nguyen, Louis; Spanos, Pol

2015-01-01

Optimal Propellant Maneuvers (OPMs) are now being used to rotate the International Space Station (ISS) and have saved hundreds of kilograms of propellant over the last two years. The savings are achieved by commanding the ISS to follow a pre-planned attitude trajectory optimized to take advantage of environmental torques. The trajectory is obtained by solving an optimal control problem. Prior to use on orbit, OPM trajectories are screened to ensure a static sun vector (SSV) does not occur during the maneuver. The SSV is an indicator that the ISS hardware temperatures may exceed thermal limits, causing damage to the components. In this paper, thermally-constrained fuel-optimal trajectories are presented that avoid an SSV and can be used throughout the year while still reducing propellant consumption significantly.

Strategic Implications of Moscow’s Concept for Collective Security in Asia

DTIC Science & Technology

1976-06-11

social liberation to this end . . . [Whereas] the Americans dream of an agreement between the two. The Soviet leaders declare a reconciliation to be...at a time when the balance of . . . forces in the world is* changing as a result of new major vic- tories on the part of world socialism and a...17 that a serious change had occurred in the relation of forces between the countries of socialism and capitalism in favor of the socialist nations

Estimating inverse-probability weights for longitudinal data with dropout or truncation: The xtrccipw command.

PubMed

Daza, Eric J; Hudgens, Michael G; Herring, Amy H

Individuals may drop out of a longitudinal study, rendering their outcomes unobserved but still well defined. However, they may also undergo truncation (for example, death), beyond which their outcomes are no longer meaningful. Kurland and Heagerty (2005, Biostatistics 6: 241-258) developed a method to conduct regression conditioning on nontruncation, that is, regression conditioning on continuation (RCC), for longitudinal outcomes that are monotonically missing at random (for example, because of dropout). This method first estimates the probability of dropout among continuing individuals to construct inverse-probability weights (IPWs), then fits generalized estimating equations (GEE) with these IPWs. In this article, we present the xtrccipw command, which can both estimate the IPWs required by RCC and then use these IPWs in a GEE estimator by calling the glm command from within xtrccipw. In the absence of truncation, the xtrccipw command can also be used to run a weighted GEE analysis. We demonstrate the xtrccipw command by analyzing an example dataset and the original Kurland and Heagerty (2005) data. We also use xtrccipw to illustrate some empirical properties of RCC through a simulation study.

Estimating inverse-probability weights for longitudinal data with dropout or truncation: The xtrccipw command

PubMed Central

Hudgens, Michael G.; Herring, Amy H.

2017-01-01

Individuals may drop out of a longitudinal study, rendering their outcomes unobserved but still well defined. However, they may also undergo truncation (for example, death), beyond which their outcomes are no longer meaningful. Kurland and Heagerty (2005, Biostatistics 6: 241–258) developed a method to conduct regression conditioning on nontruncation, that is, regression conditioning on continuation (RCC), for longitudinal outcomes that are monotonically missing at random (for example, because of dropout). This method first estimates the probability of dropout among continuing individuals to construct inverse-probability weights (IPWs), then fits generalized estimating equations (GEE) with these IPWs. In this article, we present the xtrccipw command, which can both estimate the IPWs required by RCC and then use these IPWs in a GEE estimator by calling the glm command from within xtrccipw. In the absence of truncation, the xtrccipw command can also be used to run a weighted GEE analysis. We demonstrate the xtrccipw command by analyzing an example dataset and the original Kurland and Heagerty (2005) data. We also use xtrccipw to illustrate some empirical properties of RCC through a simulation study. PMID:29755297

Exploring Mechanisms Underlying Impaired Brain Function in Gulf War Illness through Advanced Network Analysis

DTIC Science & Technology

2017-10-01

networks of the brain responsible for visual processing, mood regulation, motor coordination, sensory processing, and language command, but increased...4    For each subject, the rsFMRI voxel time-series were temporally shifted to account for differences in slice acquisition times...responsible for visual processing, mood regulation, motor coordination, sensory processing, and language command, but increased connectivity in

A Comparative Analysis of the Snort and Suricata Intrusion-Detection Systems

DTIC Science & Technology

2011-09-01

Category: Test Rules Test #6: Simple LFI Attack 43 Snort True Positive: Snort generated an alert based on the ‘/etc/ passwd ’ string passed...through an HTTP command. Suricata True Positive: Suricata generated an alert based on the ‘/etc/ passwd ’ string passed through an HTTP command

The Integration of Jesus' Great Commandment within Christian Higher Education: An Analysis of the Leadership Praxis of Dr. David S. Dockery

ERIC Educational Resources Information Center

Hickman, Tanner Franklin

2010-01-01

The purpose of this study was to better understand the leadership philosophy and key strategic actions of Dr. David S. Dockery in relation to Jesus' Great Commandment. Dockery's leadership has been instrumental in shaping and defining the meaning of Christian education during his fourteen year tenure as president of Union University. During his…

The effectiveness of problem-based learning on students’ problem solving ability in vector analysis course

NASA Astrophysics Data System (ADS)

Mushlihuddin, R.; Nurafifah; Irvan

2018-01-01

The student’s low ability in mathematics problem solving proved to the less effective of a learning process in the classroom. Effective learning was a learning that affects student’s math skills, one of which is problem-solving abilities. Problem-solving capability consisted of several stages: understanding the problem, planning the settlement, solving the problem as planned, re-examining the procedure and the outcome. The purpose of this research was to know: (1) was there any influence of PBL model in improving ability Problem solving of student math in a subject of vector analysis?; (2) was the PBL model effective in improving students’ mathematical problem-solving skills in vector analysis courses? This research was a quasi-experiment research. The data analysis techniques performed from the test stages of data description, a prerequisite test is the normality test, and hypothesis test using the ANCOVA test and Gain test. The results showed that: (1) there was an influence of PBL model in improving students’ math problem-solving abilities in vector analysis courses; (2) the PBL model was effective in improving students’ problem-solving skills in vector analysis courses with a medium category.

Method for hierarchical modeling of the command of flexible manufacturing systems

NASA Astrophysics Data System (ADS)

Ausfelder, Christian; Castelain, Emmanuel; Gentina, Jean-Claude

1994-04-01

The present paper focuses on the modeling of the command and proposes a hierarchical and modular approach which is oriented on the physical structure of FMS. The requirements issuing from monitoring of FMS are discussed and integrated in the proposed model. Its modularity makes the approach open for extensions concerning as well the production resources as the products. As a modeling tool, we have chosen Object Petri nets. The first part of the paper describes desirable features of an FMS command such as safety, robustness, and adaptability. As it is shown, these features result from the flexibility of the installation. The modeling method presented in the second part of the paper begins with a structural analysis of FMS and defines a natural command hierarchy, where the coordination of the production process, the synchronization of production resources on products, and the internal coordination are treated separately. The method is rigorous and leads to a structured and modular Petri net model which can be used for FMS simulation or translated into the final command code.

Investigation of Brittle Fractures in Graphite-Epoxy Composites Subjected to Impact

DTIC Science & Technology

1975-05-01

Dspertlmew of the Army position unless so des •i•ated by othr authrized documents. Men Goverment drawings. epeOsftions. or other data we used for any...FRACTURE CHARACTERISTICS OF SOME FIBER-STRENGTHEN,1ED EPOXY RESIN SYSTEMS, E. 1. duPont de Nemours and Company, Incorporated, Wilmington, Delaware...Corporation Report TR-0172(SZ816-15)- 1, December 1971. 35 a LAYERS WITH Ela DIFFERENIT C (EACH LAYER ISOTROPIC) E la E lb t Elc E’ In Vila V lb ý VIC

How far downstream do dams impact streamflow?

NASA Astrophysics Data System (ADS)

Troy, T.

2017-12-01

Water infrastructure can be a double-edged sword. For example, dams can provide significant flood protection and stable water supplies, but they negatively impact river ecosystems. As the United States enters an era of dam decommissioning instead of dam building, it raises the question of how far downstream dams provide protection against flood peaks and sustaining environmental flows. This study uses USGS streamflow observations, the National Inventory of Dams, and VIC-modeled streamflow as a proxy for naturalized streamflow to evaluate the scale at which dams impact a variety of hydrologic signatures such as flood return period flows, streamflow variability, and low flows. Results over the Delaware River show that the impact of dams quickly dissipates as one moves downstream, but this is due to the basin's characteristics. This analysis is performed over the contiguous United States, quantifying the length scale of impact as a function of dam capacity, position on the river network, and the hydroclimatology.

Ezetimibe in Combination With Statins Ameliorates Endothelial Dysfunction in Coronary Arteries After Stenting: The CuVIC Trial (Effect of Cholesterol Absorption Inhibitor Usage on Target Vessel Dysfunction After Coronary Stenting), a Multicenter Randomized Controlled Trial.

PubMed

Takase, Susumu; Matoba, Tetsuya; Nakashiro, Soichi; Mukai, Yasushi; Inoue, Shujiro; Oi, Keiji; Higo, Taiki; Katsuki, Shunsuke; Takemoto, Masao; Suematsu, Nobuhiro; Eshima, Kenichi; Miyata, Kenji; Yamamoto, Mitsutaka; Usui, Makoto; Sadamatsu, Kenji; Satoh, Shinji; Kadokami, Toshiaki; Hironaga, Kiyoshi; Ichi, Ikuyo; Todaka, Koji; Kishimoto, Junji; Egashira, Kensuke; Sunagawa, Kenji

2017-02-01

We sought to investigate whether treatment with ezetimibe in combination with statins improves coronary endothelial function in target vessels in coronary artery disease patients after coronary stenting. We conducted a multicenter, prospective, randomized, open-label, blinded-end point trial among 11 cardiovascular treatment centers. From 2011 to 2013, 260 coronary artery disease patients who underwent coronary stenting were randomly allocated to 2 arms (statin monotherapy, S versus ezetimibe [10 mg/d]+statin combinational therapy, E+S). We defined target vessel dysfunction as the primary composite outcome, which comprised target vessel failure during treatment and at the 6- to 8-month follow-up coronary angiography and coronary endothelial dysfunction determined via intracoronary acetylcholine testing performed in cases without target vessel failure at the follow-up coronary angiography. Coadministration of ezetimibe with statins further lowered low-density lipoprotein cholesterol levels (83±23 mg/dL in S versus 67±23 mg/dL in E+S; P<0.0001), with significant decreases in oxidized low-density lipoprotein and oxysterol levels. Among patients without target vessel failure, 46 out of 89 patients (52%) in the S arm and 34 out of 96 patients (35%) in the E+S arm were found to have coronary endothelial dysfunction (P=0.0256), and the incidence of target vessel dysfunction at follow-up was significantly decreased in the E+S arm (69/112 (62%) in S versus 47/109 (43%) in E+S; P=0.0059). A post hoc analysis of post-treatment low-density lipoprotein cholesterol-matched subgroups revealed that the incidence of both target vessel dysfunction and coronary endothelial dysfunction significantly decreased in the E+S arm, with significant reductions in oxysterol levels. The CuVIC trial (Effect of Cholesterol Absorption Inhibitor Usage on Target Vessel Dysfunction after Coronary Stenting) has shown that ezetimibe with statins, compared with statin monotherapy, improves functional prognoses, ameliorating endothelial dysfunction in stented coronary arteries, and was associated with larger decreases in oxysterol levels. © 2016 American Heart Association, Inc.

A new parallel-vector finite element analysis software on distributed-memory computers

NASA Technical Reports Server (NTRS)

Qin, Jiangning; Nguyen, Duc T.

1993-01-01

A new parallel-vector finite element analysis software package MPFEA (Massively Parallel-vector Finite Element Analysis) is developed for large-scale structural analysis on massively parallel computers with distributed-memory. MPFEA is designed for parallel generation and assembly of the global finite element stiffness matrices as well as parallel solution of the simultaneous linear equations, since these are often the major time-consuming parts of a finite element analysis. Block-skyline storage scheme along with vector-unrolling techniques are used to enhance the vector performance. Communications among processors are carried out concurrently with arithmetic operations to reduce the total execution time. Numerical results on the Intel iPSC/860 computers (such as the Intel Gamma with 128 processors and the Intel Touchstone Delta with 512 processors) are presented, including an aircraft structure and some very large truss structures, to demonstrate the efficiency and accuracy of MPFEA.

[Statistical analysis using freely-available "EZR (Easy R)" software].

PubMed

Kanda, Yoshinobu

2015-10-01

Clinicians must often perform statistical analyses for purposes such evaluating preexisting evidence and designing or executing clinical studies. R is a free software environment for statistical computing. R supports many statistical analysis functions, but does not incorporate a statistical graphical user interface (GUI). The R commander provides an easy-to-use basic-statistics GUI for R. However, the statistical function of the R commander is limited, especially in the field of biostatistics. Therefore, the author added several important statistical functions to the R commander and named it "EZR (Easy R)", which is now being distributed on the following website: http://www.jichi.ac.jp/saitama-sct/. EZR allows the application of statistical functions that are frequently used in clinical studies, such as survival analyses, including competing risk analyses and the use of time-dependent covariates and so on, by point-and-click access. In addition, by saving the script automatically created by EZR, users can learn R script writing, maintain the traceability of the analysis, and assure that the statistical process is overseen by a supervisor.

Experimental study of Bloch vector analysis in nonlinear, finite, dissipative systems

DOE Office of Scientific and Technical Information (OSTI.GOV)

D'Aguanno, G.; Mattiucci, N.; C. M. Bowden Facility, Building 7804, RDECOM, Redstone Arsenal, Alabama 35898

2010-01-15

We have investigated and experimentally demonstrated the applicability of the Bloch vector for one-dimensional, nonlinear, finite, dissipative systems. The case studied is the second harmonic generation from metallodielectric multilayer filters. In particular, we have applied the Bloch vector analysis to Ag/Ta{sub 2}O{sub 5} thin-film multilayer samples and shown the importance of the phase matching calculated through the Bloch vector. The nonlinear coefficients extracted from experimental results are consistent with previous studies. Nowadays, metal-based nanostructures play a fundamental role in nonlinear nanophotonics and nanoplasmonics. Our results clearly suggest that even in these forefront fields the Bloch vector continues to play anmore » essential role.« less

Integrated command, control, communications and computation system functional architecture

NASA Technical Reports Server (NTRS)

Cooley, C. G.; Gilbert, L. E.

1981-01-01

The functional architecture for an integrated command, control, communications, and computation system applicable to the command and control portion of the NASA End-to-End Data. System is described including the downlink data processing and analysis functions required to support the uplink processes. The functional architecture is composed of four elements: (1) the functional hierarchy which provides the decomposition and allocation of the command and control functions to the system elements; (2) the key system features which summarize the major system capabilities; (3) the operational activity threads which illustrate the interrelationahip between the system elements; and (4) the interfaces which illustrate those elements that originate or generate data and those elements that use the data. The interfaces also provide a description of the data and the data utilization and access techniques.

The contaminant analysis automation robot implementation for the automated laboratory

DOE Office of Scientific and Technical Information (OSTI.GOV)

Younkin, J.R.; Igou, R.E.; Urenda, T.D.

1995-12-31

The Contaminant Analysis Automation (CAA) project defines the automated laboratory as a series of standard laboratory modules (SLM) serviced by a robotic standard support module (SSM). These SLMs are designed to allow plug-and-play integration into automated systems that perform standard analysis methods (SAM). While the SLMs are autonomous in the execution of their particular chemical processing task, the SAM concept relies on a high-level task sequence controller (TSC) to coordinate the robotic delivery of materials requisite for SLM operations, initiate an SLM operation with the chemical method dependent operating parameters, and coordinate the robotic removal of materials from the SLMmore » when its commands and events has been established to allow ready them for transport operations as well as performing the Supervisor and Subsystems (GENISAS) software governs events from the SLMs and robot. The Intelligent System Operating Environment (ISOE) enables the inter-process communications used by GENISAS. CAA selected the Hewlett-Packard Optimized Robot for Chemical Analysis (ORCA) and its associated Windows based Methods Development Software (MDS) as the robot SSM. The MDS software is used to teach the robot each SLM position and required material port motions. To allow the TSC to command these SLM motions, a hardware and software implementation was required that allowed message passing between different operating systems. This implementation involved the use of a Virtual Memory Extended (VME) rack with a Force CPU-30 computer running VxWorks; a real-time multitasking operating system, and a Radiuses PC compatible VME computer running MDS. A GENISAS server on The Force computer accepts a transport command from the TSC, a GENISAS supervisor, over Ethernet and notifies software on the RadiSys PC of the pending command through VMEbus shared memory. The command is then delivered to the MDS robot control software using a Windows Dynamic Data Exchange conversation.« less

Portfolio Analysis for Vector Calculus

ERIC Educational Resources Information Center

Kaplan, Samuel R.

2015-01-01

Classic stock portfolio analysis provides an applied context for Lagrange multipliers that undergraduate students appreciate. Although modern methods of portfolio analysis are beyond the scope of vector calculus, classic methods reinforce the utility of this material. This paper discusses how to introduce classic stock portfolio analysis in a…

When should irrigators invest in more water-efficient technologies as an adaptation to climate change?

NASA Astrophysics Data System (ADS)

Malek, K.; Adam, J. C.; Stockle, C.; Brady, M.; Yoder, J.

2015-12-01

The western US is expected to experience more frequent droughts with higher magnitudes and persistence due to the climate change, with potentially large impacts on agricultural productivity and the economy. Irrigated farmers have many options for minimizing drought impacts including changing crops, engaging in water markets, and switching irrigation technologies. Switching to more efficient irrigation technologies, which increase water availability in the crop root zone through reduction of irrigation losses, receives significant attention because of the promise of maintaining current production with less. However, more efficient irrigation systems are almost always more capital-intensive adaptation strategy particularly compared to changing crops or trading water. A farmer's decision to switch will depend on how much money they project to save from reducing drought damages. The objective of this study is to explore when (and under what climate change scenarios) it makes sense economically for farmers to invest in a new irrigation system. This study was performed over the Yakima River Basin (YRB) in Washington State, although the tools and information gained from this study are transferable to other watersheds in the western US. We used VIC-CropSyst, a large-scale grid-based modeling framework that simulates hydrological processes while mechanistically capturing crop water use, growth and development. The water flows simulated by VIC-CropSyst were used to run the RiverWare river system and water management model (YAK-RW), which simulates river processes and calculates regional water availability for agricultural use each day (i.e., the prorationing ratio). An automated computational platform has been developed and programed to perform the economic analysis for each grid cell, crop types and future climate projections separately, which allows us to explore whether or not implementing a new irrigation system is economically viable. Results of this study indicate that climate change could justify the investment in new irrigation systems during this century, but the timing of a farmer's response is likely to depend on a variety of factors, including changes in the frequency and magnitude of drought events, current irrigation systems, climatological characteristics within the basin, and crop type.

A Global Drought and Flood Catalogue for the past 100 years

NASA Astrophysics Data System (ADS)

Sheffield, J.; He, X.; Peng, L.; Pan, M.; Fisher, C. K.; Wood, E. F.

2017-12-01

Extreme hydrological events cause the most impacts of natural hazards globally, impacting on a wide range of sectors including, most prominently, agriculture, food security and water availability and quality, but also on energy production, forestry, health, transportation and fisheries. Understanding how floods and droughts intersect, and have changed in the past provides the basis for understanding current risk and how it may change in the future. To do this requires an understanding of the mechanisms associated with events and therefore their predictability, attribution of long-term changes in risk, and quantification of projections of changes in the future. Of key importance are long-term records of relevant variables so that risk can be quantified more accurately, given the growing acknowledgement that risk is not stationary under long-term climate variability and climate change. To address this, we develop a catalogue of drought and flood events based on land surface and hydrodynamic modeling, forced by a hybrid meteorological dataset that draws from the continuity and coverage of reanalysis, and satellite datasets, merged with global gauge databases. The meteorological dataset is corrected for temporal inhomogeneities, spurious trends and variable inter-dependencies to ensure long-term consistency, as well as realistic representation of short-term variability and extremes. The VIC land surface model is run for the past 100 years at 0.25-degree resolution for global land areas. The VIC runoff is then used to drive the CaMa-Flood hydrodynamic model to obtain information on flood inundation risk. The model outputs are compared to satellite based estimates of flood and drought conditions and the observational flood record. The data are analyzed in terms of the spatio-temporal characteristics of large-scale flood and drought events with a particular focus on characterizing the long-term variability in risk. Significant changes in risk occur on multi-decadal time scales and are mostly associated with variability in the North Atlantic and Pacific. The catalogue can be used for analysis of extreme events, risk assessment, and as a benchmark for model evaluation.

Air Mobility Command’s Total Force Integration: A Critical Analysis

DTIC Science & Technology

2012-02-26

variety of techniques available to positively change culture . 9 Changing assumptions of in-group collectivist requires increasing breadth and open...there have been issues. Command structure, cultural differences and vague guidance for implementation have plagued Air Mobility Command’s...through the Governor and not the President of the United States. Cultural Considerations The purpose of this section is to identify and discuss

Data Analysis & Statistical Methods for Command File Errors

NASA Technical Reports Server (NTRS)

Meshkat, Leila; Waggoner, Bruce; Bryant, Larry

2014-01-01

This paper explains current work on modeling for managing the risk of command file errors. It is focused on analyzing actual data from a JPL spaceflight mission to build models for evaluating and predicting error rates as a function of several key variables. We constructed a rich dataset by considering the number of errors, the number of files radiated, including the number commands and blocks in each file, as well as subjective estimates of workload and operational novelty. We have assessed these data using different curve fitting and distribution fitting techniques, such as multiple regression analysis, and maximum likelihood estimation to see how much of the variability in the error rates can be explained with these. We have also used goodness of fit testing strategies and principal component analysis to further assess our data. Finally, we constructed a model of expected error rates based on the what these statistics bore out as critical drivers to the error rate. This model allows project management to evaluate the error rate against a theoretically expected rate as well as anticipate future error rates.

Poynting vector measurements of electromagnetic ion cyclotron waves in the plasmasphere

NASA Technical Reports Server (NTRS)

Labelle, J.; Treumann, R. A.

1992-01-01

Results are presented from an analysis of the June 6, 1985 Pc 2 measurements for which E, B, and delta-N were all analyzed. The event occurred in the duskside overlap region between the plasmaspheric bulge and the ion ring current. Results of the Poynting vector analysis of the R and L mode components show both of them to be characterized by northward Poynting vector, indicating energy flux away from the equator. The value of the Poynting vector was found to be about 3 microW/sq m.

Computer-based visual communication in aphasia.

PubMed

Steele, R D; Weinrich, M; Wertz, R T; Kleczewska, M K; Carlson, G S

1989-01-01

The authors describe their recently developed Computer-aided VIsual Communication (C-VIC) system, and report results of single-subject experimental designs probing its use with five chronic, severely impaired aphasic individuals. Studies replicate earlier results obtained with a non-computerized system, demonstrate patient competence with the computer implementation, extend the system's utility, and identify promising areas of application. Results of the single-subject experimental designs clarify patients' learning, generalization, and retention patterns, and highlight areas of performance difficulties. Future directions for the project are indicated.

Small computer interface to a stepper motor

NASA Technical Reports Server (NTRS)

Berry, Fred A., Jr.

1986-01-01

A Commodore VIC-20 computer has been interfaced with a stepper motor to provide an inexpensive stepper motor controller. Only eight transistors and two integrated circuits compose the interface. The software controls the parallel interface of the computer and provides the four phase drive signals for the motor. Optical sensors control the zeroing of the 12-inch turntable positioned by the controller. The computer calculates the position information and movement of the table and may be programmed in BASIC to execute automatic sequences.

Making medical records professional(s).

PubMed

Mason, A

1987-07-01

In 1986 a joint medical records project group was set up by the Institute of Health Services Management, the Association of Health Care Information and Medical Records Officers and the NHS Training Authority, with Mr Vic Peel as chairman. The group was supported by Arthur Andersen & Co, management consultants. The following is a shortened and edited version of an interim report drafted for the group by Dr Alastair Mason. It is intended for discussion and does not yet represent the definitive views of the sponsoring bodies.

The Coast Artillery Journal. Volume 79, Number 6, November-December 1936

DTIC Science & Technology

1936-12-01

news from the enveloping right wing toward which all Schlieffen-trained staff officers looked for vic - tory. OHL-Kaiser, staff officers, civil and...many of its means of defense as possible. 1936 ~ _ PROVISIONS OF DIRECTIVE OF AUGUST 27 _- - THE EXECUTION SCALE o 5 10 20 3{) THE WILL OF THE LEADER...the Oise and that only weak rear guards were in front of his right. On the 29th he would attack the fortress of La Fere. This report could mean only one

Cognitive behaviour therapy to prevent harmful compliance with command hallucinations (COMMAND): a randomised controlled trial.

PubMed

Birchwood, Max; Michail, Maria; Meaden, Alan; Tarrier, Nicholas; Lewis, Shon; Wykes, Til; Davies, Linda; Dunn, Graham; Peters, Emmanuelle

2014-06-01

Acting on command hallucinations in psychosis can have serious consequences for the individual and for other people and is a major cause of clinical and public concern. No evidence-based treatments are available to reduce this risk behaviour. We therefore tested our new cognitive therapy to challenge the perceived power of voices to inflict harm on the voice hearer if commands are not followed, thereby reducing the hearer's motivation to comply. In COMMAND, a single-blind, randomised controlled trial, eligible participants from three centres in the UK who had command hallucinations for at least 6 months leading to major episodes of harm to themselves or other people were assigned in a 1: 1 ratio to cognitive therapy for command hallucinations + treatment as usual versus just treatment as usual for 9 months. Only the raters were masked to treatment assignment. The primary outcome was harmful compliance. Analysis was by intention to treat. The trial is registered, number ISRCTN62304114. 98 (50%) of 197 participants were assigned to cognitive therapy for command hallucinations + treatment as usual and 99 (50%) to treatment as usual. At 18 months, 39 (46%) of 85 participants in the treatment as usual group fully complied with the voices compared with 22 (28%) of 79 in the cognitive therapy for command hallucinations + treatment as usual group (odds ratio 0·45, 95% CI 0·23-0·88, p=0·021). At 9 months the treatment effect was not significant (0·74, 0·40-1·39, p=0·353). However, the treatment by follow-up interaction was not significant and the treatment effect common to both follow-up points was 0·57 (0·33-0·98, p=0·042). This is the first trial to show a clinically meaningful reduction in risk behaviour associated with commanding voices. We will next determine if change in power was the mediator of change. Further more complex trials are needed to identify the most influential components of the treatment in reducing power and compliance. UK Medical Research Council and the National Institute for Health Research. Copyright © 2014 Elsevier Ltd. All rights reserved.

A procedure for landslide susceptibility zonation by the conditional analysis method1

NASA Astrophysics Data System (ADS)

Clerici, Aldo; Perego, Susanna; Tellini, Claudio; Vescovi, Paolo

2002-12-01

Numerous methods have been proposed for landslide probability zonation of the landscape by means of a Geographic Information System (GIS). Among the multivariate methods, i.e. those methods which simultaneously take into account all the factors contributing to instability, the Conditional Analysis method applied to a subdivision of the territory into Unique Condition Units is particularly straightforward from a conceptual point of view and particularly suited to the use of a GIS. In fact, working on the principle that future landslides are more likely to occur under those conditions which led to past instability, landslide susceptibility is defined by computing the landslide density in correspondence with different combinations of instability factors. The conceptual simplicity of this method, however, does not necessarily imply that it is simple to implement, especially as it requires rather complex operations and a high number of GIS commands. Moreover, there is the possibility that, in order to achieve satisfactory results, the procedure has to be repeated a few times changing the factors or modifying the class subdivision. To solve this problem, we created a shell program which, by combining the shell commands, the GIS Geographical Research Analysis Support System (GRASS) commands and the gawk language commands, carries out the whole procedure automatically. This makes the construction of a Landslide Susceptibility Map easy and fast for large areas too, and even when a high spatial resolution is adopted, as shown by application of the procedure to the Parma River basin, in the Italian Northern Apennines.

A view finder control system for an earth observation satellite

NASA Astrophysics Data System (ADS)

Steyn, H.

2004-11-01

A real time TV view finder is used on-board a low earth orbiting (LEO) satellite to manually select targets for imaging from a ground station within the communication footprint of the satellite. The attitude control system on the satellite is used to steer the satellite using commands from the groundstation and a television camera onboard the satellite will then downlink a television signal in real time to a monitor screen in the ground station. The operator in the feedback loop will be able to manually steer the boresight of the satellite's main imager towards interested target areas e.g. to avoid clouds or correct for any attitude pointing errors. Due to a substantial delay (in the order of a second) in the view finding feedback loop and the narrow field of view of the main imager, the operator has to be assisted by the onboard attitude control system to stabilise and track the target area visible on the monitor screen. This paper will present the extended Kalman filter used to estimate the satellite's attitude angles using quaternions and the bias vector component of the 3-axis inertial rate sensors (gyros). Absolute attitude sensors (i.e. sun, horizon and magnetic) are used to supply the measurement vectors to correct the filter states during the view finder manoeuvres. The target tracking and rate steering reaction wheel controllers to accurately point and stabilise the satellite will be presented. The reference generator for the satellite to target attitude and rate vectors as used by the reaction wheel controllers will be derived.

Analysis of the Department of Defense Pre-Award Contracting Process

DTIC Science & Technology

2014-12-01

Justification and Approval JBSA Joint Base San Antonio KPIs Key Performance Indicators MAJCOMs Major Command MP Mandatory Commands NAVIAR...meets desired results. Results-based performance measurement establishes key performance indicators ( KPIs ) that determine whether procurement...or goals, and underlying business processes (Cullen, 2009, p. 38). Within each quadrant, Cullen provided examples of KPIs that serve to measure

Targets for Marine Corps Purchasing and Supply Management Initiatives: Spend Analysis Findings

DTIC Science & Technology

2011-01-01

TRANSPORTATION INTERNATIONAL AFFAIRS LAW AND BUSINESS NATIONAL SECURITY POPULATION AND AGING PUBLIC SAFETY SCIENCE AND TECHNOLOGY TERRORISM AND...States Transportation Command UNICOR Federal Prison Industries, Inc. USMC United States Marine Corps WHS/SIAD Washington Headquarters Services...Services Admin- istration (GSA), and the United States Transportation Command (TRANSCOM), as well as via Military Interdepartmental Purchase Requests

General Electromagnetic Model for the Analysis of Complex Systems (GEMACS) Engineering Manual (Version 3). Volume 3.

DTIC Science & Technology

1983-09-01

processor. How- ever, upon completion of the restart initialization, additional commands may be added or original commands deleted with normal input...written IOSI Scratch logical unit designator IOS1SV Saved value of lOS1 IOS2 Scratch logical unit designator IR Index pointer to upper triangular matrix

Active Duty C-17 Aircraft Commander Fuel Efficiency Metrics and Goal Evaluation

DTIC Science & Technology

2015-03-26

document/AFD-140304-043.pdf. AMC/A3F. “AMC Fuel Metrics,” Air Mobility Command, 2014. Bandura , A. “ Social Cognitive Theory of Self-Regulation...qualitative criteria analysis, picked the most effective metric, and utilized Goal Setting Theory (GST) to couple the metric with an attainable goal...9 Goal-Setting Theory

Pattern Recognition Control Design

NASA Technical Reports Server (NTRS)

Gambone, Elisabeth

2016-01-01

Spacecraft control algorithms must know the expected spacecraft response to any command to the available control effectors, such as reaction thrusters or torque devices. Spacecraft control system design approaches have traditionally relied on the estimated vehicle mass properties to determine the desired force and moment, as well as knowledge of the effector performance to efficiently control the spacecraft. A pattern recognition approach can be used to investigate the relationship between the control effector commands and the spacecraft responses. Instead of supplying the approximated vehicle properties and the effector performance characteristics, a database of information relating the effector commands and the desired vehicle response can be used for closed-loop control. A Monte Carlo simulation data set of the spacecraft dynamic response to effector commands can be analyzed to establish the influence a command has on the behavior of the spacecraft. A tool developed at NASA Johnson Space Center (Ref. 1) to analyze flight dynamics Monte Carlo data sets through pattern recognition methods can be used to perform this analysis. Once a comprehensive data set relating spacecraft responses with commands is established, it can be used in place of traditional control laws and gains set. This pattern recognition approach can be compared with traditional control algorithms to determine the potential benefits and uses.

Genetic Modeling of Radiation Injury in Prostate Cancer Patients Treated with Radiotherapy

DTIC Science & Technology

2017-10-01

approaches in the GWAS meta-analysis: 1) logistic regression to test association of each SNP with grade 1 or worse toxicity at 2 years post ...Annual PREPARED FOR: U.S. Army Medical Research and Materiel Command Fort Detrick, Maryland 21702-5012 DISTRIBUTION STATEMENT: Approved for...Army Medical Research and Materiel Command Fort Detrick, Maryland 21702-5012 11. SPONSOR/MONITOR’S REPORT NUMBER(S) 12. DISTRIBUTION / AVAILABILITY

Decision Analysis of the Benefits and Costs of Screening for Prostate Cancer

DTIC Science & Technology

2011-08-01

REPORT DATE: TYPE OF REPORT: Annual PREPARED FOR: U.S. Army Medical Research and Materiel Command...MONITORING AGENCY NAME(S) AND ADDRESS(ES) 10. SPONSOR/MONITOR’S ACRONYM(S) U.S. Army Medical Research and Materiel Command Fort Detrick, Maryland...constructed and in men aged 55 to 75. Results of this model have been published in the Journal of the American Medical Association, presented at

Equal Opportunity Leadership Training for Company-Level Chain of Command

DTIC Science & Technology

1981-01-01

Relations/ Equal Opportunity Training in USAREUR, ARI Technical Report TR-78-B10, Alexandria, Va.: US. Army Research Institute for the Behavioral and Social ...Behavioral and Social Sciences, 1978. Marcia A. Gilbert and Peter G. Nordlie, An Analysis of Race Relations/ Equal Opportunity Training in USAREUR, ARI...Technical Report 534 - EQUAL OPPORTUNITY LEADERSHIP TRAINING FOR COMPANY-LEVEL CHAIN OF COMMAND Dale K. Brown, Silas J. White, Exequiel R. Sevilla

Efficacy and safety of a clinically relevant foamy vector design in human hematopoietic repopulating cells.

PubMed

Everson, Elizabeth M; Hocum, Jonah D; Trobridge, Grant D

2018-06-23

Previous studies have shown that foamy viral (FV) vectors are a promising alternative to gammaretroviral and lentiviral vectors and insulators can improve FV vector safety. However, in a previous analysis of insulator effects on FV vector safety, strong viral promoters were used to elicit genotoxic events. Here we developed and analyzed the efficacy and safety of a high-titer, clinically relevant FV vector driven by the housekeeping promoter elongation factor-1α and insulated with an enhancer blocking A1 insulator (FV-EGW-A1). Human CD34 + cord blood cells were exposed to an enhanced green fluorescent protein expressing vector, FV-EGW-A1, at a multiplicity of infection of 10 and then maintained in vitro or transplanted into immunodeficient mice. Flow cytometry was used to measure engraftment and marking in vivo. FV vector integration sites were analyzed to assess safety. FV-EGW-A1 resulted in high-marking, multi-lineage engraftment of human repopulating cells with no evidence of silencing. Engraftment was highly polyclonal with no clonal dominance and a promising safety profile based on integration site analysis. An FV vector with an elongation factor-1α promoter and an A1 insulator is a promising vector design for use in the clinic. This article is protected by copyright. All rights reserved.

A recombinant fowl adenovirus expressing the S1 gene of infectious bronchitis virus protects against challenge with infectious bronchitis virus.

PubMed

Johnson, Michael A; Pooley, Catherine; Ignjatovic, Jagoda; Tyack, Scott G

2003-06-20

The spike peplomer S1 subunit sequence from avian infectious bronchitis virus (IBV) Vic S strain was expressed in a plasmid under the control of the fowl adenovirus (FAV) major late promoter (MLP). Two recombinants were constructed in FAV serotype 8 (FAV 8) by inserting the expression cassette between the SnaBI and XbaI restriction enzyme sites (clone DA3) or between the SpeI sites (clone CA6-20). Expression of the S1 gene in the recombinants was confirmed by reverse transcription-polymerase chain reaction (RT-PCR) by 20h post-infection. Commercial broiler chickens were orally vaccinated at day 0 or day 6 post-hatch and challenged at day 35 post-hatch. FAV antibody ELISA confirmed that maternal antibody directed against inclusion body hepatitis (serotype 8) had decayed in control birds and that FAV specific serum IgG responses were produced in vaccinated birds at the time of challenge. Further, an S1 specific antibody response was detected prior to challenge. Birds were challenged with either Vic S (serotype B) or N1/62 (serotype C) strains of IBV. The tracheas of challenged birds were analyzed by RT-PCR and re-isolation of virus. In birds vaccinated at day 6, 90-100% protection at the trachea was induced against either homologous or heterologous challenge. The construction of a recombinant FAV expressing S1 of IBV demonstrates the potential of an alternative vaccination strategy against IBV.

The 9th International Veterinary Immunology Symposium.

PubMed

Lunney, Joan K; Kai, Chieko; Inumaru, Shigeki; Onodera, Takashi

2012-07-15

This special issue of Veterinary Immunology and Immunopathology summarizes the Proceedings of the 9th International Veterinary Immunology Symposium (9th IVIS) held August 2010, in Tokyo, Japan. Over 340 delegates from 30 countries discussed research progress analyzing the immune systems of numerous food animals and wildlife, probing basic immunity and the influence of stress, genetics, nutrition, endocrinology and reproduction. Major presentations addressed defense against pathogens and alternative control and prevention strategies including vaccines, adjuvants and novel biotherapeutics. A special Organisation for Economic Co-operation and Development (OECD) Co-operative Research Programme Sponsored Conference on "Vaccination and Diagnosis for Food Safety in Agriculture" highlighted the particular issue of "Immunology in Bovine Paratuberculosis". In April 2010 there was an outbreak of foot-and-mouth disease (FMD) in the southern part of Japan. This stimulated a special 9th IVIS session on FMD, sponsored by the World Organization for Animal Health (OIE) and the Ministry of Agriculture, Forestry and Fisheries (MAFF) of Japan, to discuss improvements of FMD vaccines, their use in FMD control, and risk assessment for decision management. The 9th IVIS was supported by the Veterinary Immunology Committee (VIC) of the International Union of Immunological Societies (IUIS) and included workshops for its MHC and Toolkit Committees. Finally VIC IUIS presented its 2010 Distinguished Service Award to Dr. Kazuya Yamanouchi for "outstanding contributions to the veterinary immunology community" and its 2010 Distinguished Veterinary Immunologist Award to Dr. Douglas F. Antczak for "outstanding research on equine immunology". Published by Elsevier B.V.

Method for predicting peptide detection in mass spectrometry

DOEpatents

Kangas, Lars [West Richland, WA; Smith, Richard D [Richland, WA; Petritis, Konstantinos [Richland, WA

2010-07-13

A method of predicting whether a peptide present in a biological sample will be detected by analysis with a mass spectrometer. The method uses at least one mass spectrometer to perform repeated analysis of a sample containing peptides from proteins with known amino acids. The method then generates a data set of peptides identified as contained within the sample by the repeated analysis. The method then calculates the probability that a specific peptide in the data set was detected in the repeated analysis. The method then creates a plurality of vectors, where each vector has a plurality of dimensions, and each dimension represents a property of one or more of the amino acids present in each peptide and adjacent peptides in the data set. Using these vectors, the method then generates an algorithm from the plurality of vectors and the calculated probabilities that specific peptides in the data set were detected in the repeated analysis. The algorithm is thus capable of calculating the probability that a hypothetical peptide represented as a vector will be detected by a mass spectrometry based proteomic platform, given that the peptide is present in a sample introduced into a mass spectrometer.

Hydrological climate change projections for Central America

NASA Astrophysics Data System (ADS)

Hidalgo, Hugo G.; Amador, Jorge A.; Alfaro, Eric J.; Quesada, Beatriz

2013-07-01

Runoff climate change projections for the 21st century were calculated from a suite of 30 General Circulation Model (GCM) simulations for the A1B emission scenario in a 0.5° × 0.5° grid over Central America. The GCM data were downscaled using a version of the Bias Correction and Spatial Downscaling (BCSD) method and then used in the Variable Infiltration Capacity (VIC) macroscale hydrological model. The VIC model showed calibration skill in Honduras, Nicaragua, Costa Rica and Panama, but the results for some of the northern countries (Guatemala, El Salvador and Belize) and for the Caribbean coast of Central America was not satisfactory. Bias correction showed to remove effectively the biases in the GCMs. Results of the projected climate in the 2050-2099 period showed median significant reductions in precipitation (as much as 5-10%) and runoff (as much as 10-30%) in northern Central America. Therefore in this sub-region the prevalence of severe drought may increase significantly in the future under this emissions scenario. Northern Central America could warm as much as 3 °C during 2050-2099 and southern Central America could reach increases as much as 4 °C during the same period. The projected dry pattern over Central America is consistent with a southward displacement of the Intertropical Convergence Zone (ITCZ). In addition, downscaling of the NCEP/NCAR Reanalysis data from 1948 to 2012 and posterior run in VIC, for two locations in the northern and southern sub-regions of Central America, suggested that the annual runoff has been decreasing since ca. 1980, which is consistent with the sign of the runoff changes of the GCM projections. However, the Reanalysis 1980-2012 drying trends are generally much stronger than the corresponding GCM trends. Among the possible reasons for that discrepancy are model deficiencies, amplification of the trends due to constructive interference with natural modes of variability in the Reanalysis data, errors in the Reanalysis (modeled) precipitation data, and that the drying signal is more pronounced than predicted by the emissions scenario used. A few studies show that extrapolations of future climate from paleoclimatic indicators project a wetter climate in northern Central America, which is inconsistent with the modeling results presented here. However, these types of extrapolations should be done with caution, as the future climate responds to an extra forcing mechanism (anthropogenic) that was not present prehistorically and therefore the response could also be different than in the past.

System for Automated Calibration of Vector Modulators

NASA Technical Reports Server (NTRS)

Lux, James; Boas, Amy; Li, Samuel

2009-01-01

Vector modulators are used to impose baseband modulation on RF signals, but non-ideal behavior limits the overall performance. The non-ideal behavior of the vector modulator is compensated using data collected with the use of an automated test system driven by a LabVIEW program that systematically applies thousands of control-signal values to the device under test and collects RF measurement data. The technology innovation automates several steps in the process. First, an automated test system, using computer controlled digital-to-analog converters (DACs) and a computer-controlled vector network analyzer (VNA) systematically can apply different I and Q signals (which represent the complex number by which the RF signal is multiplied) to the vector modulator under test (VMUT), while measuring the RF performance specifically, gain and phase. The automated test system uses the LabVIEW software to control the test equipment, collect the data, and write it to a file. The input to the Lab - VIEW program is either user-input for systematic variation, or is provided in a file containing specific test values that should be fed to the VMUT. The output file contains both the control signals and the measured data. The second step is to post-process the file to determine the correction functions as needed. The result of the entire process is a tabular representation, which allows translation of a desired I/Q value to the required analog control signals to produce a particular RF behavior. In some applications, corrected performance is needed only for a limited range. If the vector modulator is being used as a phase shifter, there is only a need to correct I and Q values that represent points on a circle, not the entire plane. This innovation has been used to calibrate 2-GHz MMIC (monolithic microwave integrated circuit) vector modulators in the High EIRP Cluster Array project (EIRP is high effective isotropic radiated power). These calibrations were then used to create correction tables to allow the commanding of the phase shift in each of four channels used as a phased array for beam steering of a Ka-band (32-GHz) signal. The system also was the basis of a breadboard electronic beam steering system. In this breadboard, the goal was not to make systematic measurements of the properties of a vector modulator, but to drive the breadboard with a series of test patterns varying in phase and amplitude. This is essentially the same calibration process, but with the difference that the data collection process is oriented toward collecting breadboard performance, rather than the measurement of output from a network analyzer.

Visualizing vector field topology in fluid flows

NASA Technical Reports Server (NTRS)

Helman, James L.; Hesselink, Lambertus

1991-01-01

Methods of automating the analysis and display of vector field topology in general and flow topology in particular are discussed. Two-dimensional vector field topology is reviewed as the basis for the examination of topology in three-dimensional separated flows. The use of tangent surfaces and clipping in visualizing vector field topology in fluid flows is addressed.

Improve Problem Solving Skills through Adapting Programming Tools

NASA Technical Reports Server (NTRS)

Shaykhian, Linda H.; Shaykhian, Gholam Ali

2007-01-01

There are numerous ways for engineers and students to become better problem-solvers. The use of command line and visual programming tools can help to model a problem and formulate a solution through visualization. The analysis of problem attributes and constraints provide insight into the scope and complexity of the problem. The visualization aspect of the problem-solving approach tends to make students and engineers more systematic in their thought process and help them catch errors before proceeding too far in the wrong direction. The problem-solver identifies and defines important terms, variables, rules, and procedures required for solving a problem. Every step required to construct the problem solution can be defined in program commands that produce intermediate output. This paper advocates improved problem solving skills through using a programming tool. MatLab created by MathWorks, is an interactive numerical computing environment and programming language. It is a matrix-based system that easily lends itself to matrix manipulation, and plotting of functions and data. MatLab can be used as an interactive command line or a sequence of commands that can be saved in a file as a script or named functions. Prior programming experience is not required to use MatLab commands. The GNU Octave, part of the GNU project, a free computer program for performing numerical computations, is comparable to MatLab. MatLab visual and command programming are presented here.

Medium range flood forecasts at global scale

NASA Astrophysics Data System (ADS)

Voisin, N.; Wood, A. W.; Lettenmaier, D. P.; Wood, E. F.

2006-12-01

While weather and climate forecast methods have advanced greatly over the last two decades, this capability has yet to be evidenced in mitigation of water-related natural hazards (primarily floods and droughts), especially in the developing world. Examples abound of extreme property damage and loss of life due to floods in the underdeveloped world. For instance, more than 4.5 million people were affected by the July 2000 flooding of the Mekong River and its tributaries in Cambodia, Vietnam, Laos and Thailand. The February- March 2000 floods in the Limpopo River of Mozambique caused extreme disruption to that country's fledgling economy. Mitigation of these events through advance warning has typically been modest at best. Despite the above noted improvement in weather and climate forecasts, there is at present no system for forecasting of floods globally, notwithstanding that the potential clearly exists. We describe a methodology that is eventually intended to generate global flood predictions routinely. It draws heavily from the experimental North American Land Data Assimilation System (NLDAS) and the companion Global Land Data Assimilation System (GLDAS) for development of nowcasts, and the University of Washington Experimental Hydrologic Prediction System to develop ensemble hydrologic forecasts based on Numerical Weather Prediction (NWP) models which serve both as nowcasts (and hence reduce the need for in situ precipitation and other observations in parts of the world where surface networks are critically deficient) and provide forecasts for lead times as long as fifteen days. The heart of the hydrologic modeling system is the University of Washington/Princeton University Variable Infiltration Capacity (VIC) macroscale hydrology model. In the prototype (tested using retrospective data), VIC is driven globally up to the time of forecast with daily ERA40 precipitation (rescaled on a monthly basis to a station-based global climatology), ERA40 wind, and ERA40 average surface air temperature (with temperature ranges adjusted to a station-based climatology). In the retrospective forecasting mode, VIC is driven by global NCEP ensemble 15-day reforecasts provided by Tom Hamill (NOAA/ERL), bias corrected with respect to the adjusted ERA40 data and further downscaled spatially using higher spatial resolution Global Precipitation Climatology Project (GPCP) 1dd daily precipitation. Downward solar and longwave radiation, surface relative humidity, and other model forcings are derived from relationships with the daily temperature range during both the retrospective (spinup) and forecast period. The initial system is implemented globally at one-half degree spatial resolution. We evaluate model performance retrospectively for predictions of major floods for the Oder River in 1997, the Mekong River in 2000 and the Limpopo River in 2000.

Examining controls on peak annual streamflow and floods in the Fraser River Basin of British Columbia

NASA Astrophysics Data System (ADS)

Curry, Charles L.; Zwiers, Francis W.

2018-04-01

The Fraser River Basin (FRB) of British Columbia is one of the largest and most important watersheds in western North America, and home to a rich diversity of biological species and economic assets that depend implicitly upon its extensive riverine habitats. The hydrology of the FRB is dominated by snow accumulation and melt processes, leading to a prominent annual peak streamflow invariably occurring in May-July. Nevertheless, while annual peak daily streamflow (APF) during the spring freshet in the FRB is historically well correlated with basin-averaged, 1 April snow water equivalent (SWE), there are numerous occurrences of anomalously large APF in below- or near-normal SWE years, some of which have resulted in damaging floods in the region. An imperfect understanding of which other climatic factors contribute to these anomalously large APFs hinders robust projections of their magnitude and frequency. We employ the Variable Infiltration Capacity (VIC) process-based hydrological model driven by gridded observations to investigate the key controlling factors of anomalous APF events in the FRB and four of its subbasins that contribute nearly 70 % of the annual flow at Fraser-Hope. The relative influence of a set of predictors characterizing the interannual variability of rainfall, snowfall, snowpack (characterized by the annual maximum value, SWEmax), soil moisture and temperature on simulated APF at Hope (the main outlet of the FRB) and at the subbasin outlets is examined within a regression framework. The influence of large-scale climate modes of variability (the Pacific Decadal Oscillation (PDO) and the El Niño-Southern Oscillation - ENSO) on APF magnitude is also assessed, and placed in context with these more localized controls. The results indicate that next to SWEmax (univariate Spearman correlation with APF of ρ ^ = 0.64; 0.70 (observations; VIC simulation)), the snowmelt rate (ρ ^ = 0.43 in VIC), the ENSO and PDO indices (ρ ^ = -0.40; -0.41) and (ρ ^ = -0.35; -0.38), respectively, and rate of warming subsequent to the date of SWEmax (ρ ^ = 0.26; 0.38), are the most influential predictors of APF magnitude in the FRB and its subbasins. The identification of these controls on annual peak flows in the region may be of use in understanding seasonal predictions or future projected streamflow changes.

Analysis, design, and testing of a low cost, direct force command linear proof mass actuator for structural control

NASA Technical Reports Server (NTRS)

Slater, G. L.; Shelley, Stuart; Jacobson, Mark

1993-01-01

In this paper, the design, analysis, and test of a low cost, linear proof mass actuator for vibration control is presented. The actuator is based on a linear induction coil from a large computer disk drive. Such disk drives are readily available and provide the linear actuator, current feedback amplifier, and power supply for a highly effective, yet inexpensive, experimental laboratory actuator. The device is implemented as a force command input system, and the performance is virtually the same as other, more sophisticated, linear proof mass systems.