Measurement of the time resolution of small SiPM-based scintillation counters

NASA Astrophysics Data System (ADS)

Kravchenko, E. A.; Porosev, V. V.; Savinov, G. A.

2017-12-01

In this research, we evaluated the timing resolution of SiPM-based scintillation detector on a 1-GeV electron beam "extracted" from VEPP-4M. We tested small scintillation crystals of pure CsI, YAP, LYSO, and LFS-3 with HAMAMATSU S10362-33-025C and S13360-3050CS. The CsI scintillator together with HAMAMATSU S13360-3050CS demonstrated the best results. Nevertheless, the achieved time resolution of ~80 ps (RMS) relates mainly to the photodetector itself. It makes the silicon photomultiplier an attractive candidate to replace other devices in applications where sub-nanosecond accuracy is required.

Measurement of the e{sup +}e{sup –} → ηπ{sup +}π{sup –} cross section in the center-of-mass energy range 1.22–2.00 GeV with the SND detector at the VEPP-2000 collider

DOE Office of Scientific and Technical Information (OSTI.GOV)

Shtol, D. A., E-mail: D.A.Shtol@inp.nsk.su

2015-12-15

In the experiment with the SND detector at the VEPP-2000 e+e– collider the cross section for the process e{sup +}e{sup –} → ηπ{sup +}π{sup –} has been measured in the center-of-mass energy range from 1.22 to 2.00 GeV. Obtained results are in agreement with previous measurements and have better accuracy. The energy dependence of the e{sup +}e{sup –} → ηπ{sup +}π{sup –} cross section has been fitted with the vector-meson dominance model. From this fit the product of the branching fractions B(ρ(1450) → ηπ{sup +}π{sup –})B(ρ(1450) → π{sup +}π{sup –}) has been extracted and compared with the same products formore » (ρ(1450) → ωΠ{sup 0} and (ρ(1450) → π{sup +}π{sup –} decays. The obtained cross section data have been also used to test the conservation of vector current hypothesis.« less

Measurement of Γee(J /ψ) with KEDR detector

NASA Astrophysics Data System (ADS)

Anashin, V. V.; Aulchenko, V. M.; Baldin, E. M.; Barladyan, A. K.; Barnyakov, A. Y.; Barnyakov, M. Y.; Baru, S. E.; Bedny, I. V.; Blinov, A. E.; Blinov, V. E.; Bobrov, A. V.; Bobrovnikov, V. S.; Bogomyagkov, A. V.; Bondar, A. E.; Bondarev, D. V.; Buzykaev, A. R.; Eidelman, S. I.; Glukhovchenko, Y. M.; Gulevich, V. V.; Gusev, D. V.; Karnaev, S. E.; Karpov, G. V.; Karpov, S. V.; Kharlamova, T. A.; Kiselev, V. A.; Kononov, S. A.; Kotov, K. Y.; Kravchenko, E. A.; Kulikov, V. F.; Kurkin, G. Y.; Kuper, E. A.; Levichev, E. B.; Maksimov, D. A.; Malyshev, V. M.; Maslennikov, A. L.; Medvedko, A. S.; Meshkov, O. I.; Mishnev, S. I.; Morozov, I. I.; Muchnoi, N. Y.; Neufeld, V. V.; Nikitin, S. A.; Nikolaev, I. B.; Okunev, I. N.; Onuchin, A. P.; Oreshkin, S. B.; Orlov, I. O.; Osipov, A. A.; Peleganchuk, S. V.; Pivovarov, S. G.; Piminov, P. A.; Petrov, V. V.; Poluektov, A. O.; Popkov, I. N.; Prisekin, V. G.; Rezanova, O. L.; Ruban, A. A.; Sandyrev, V. K.; Savinov, G. A.; Shamov, A. G.; Shatilov, D. N.; Shwartz, B. A.; Simonov, E. A.; Sinyatkin, S. V.; Skovpen, Y. I.; Skrinsky, A. N.; Smaluk, V. V.; Sokolov, A. V.; Sukharev, A. M.; Starostina, E. V.; Talyshev, A. A.; Tayursky, V. A.; Telnov, V. I.; Tikhonov, Y. A.; Todyshev, K. Y.; Tumaikin, G. M.; Usov, Y. V.; Vorobiov, A. I.; Yushkov, A. N.; Zhilich, V. N.; Zhulanov, V. V.; Zhuravlev, A. N.

2018-05-01

The product of the electronic width of the J/ψ meson and the branching fractions of its decay to hadrons and electrons has been measured using the KEDR detector at the VEPP-4M e + e - collider. The obtained values are Γ_{ee}(J/ψ )=5.550± 0.056± 0.089 Γ_{ee}(J/ψ )\\cdotp B_{hadrons}(J/ψ )=4.884± 0.048± 0.078 keV Γ_{ee}(J/ψ )\\cdotp B_{ee}(J/ψ )=0.3331± 0.0066± 0.0040 keV. The uncertainties shown are statistical and systematic, respectively. Using the result presented and the world-average value of the electronic branching fraction, one obtains the total width of the J/ψ meson: Γ =92.94± 1.83keV. These results are consistent with the previous experiments.

Analysis of GPS Data Using Near Real-Time Data from the Volcano Exploration Project in the Community College Classroom (Invited)

NASA Astrophysics Data System (ADS)

House, M.; Nagy-Shadman, E.; Wilbur, B.

2010-12-01

Using real-time data or near-real-time data in the classroom is an exciting prospect in Introductory Physical Geology courses, especially since it promises to offer students a chance to experience the excitement and uncertainty associated with the study of the natural world that appeals to so many of their instructors. However, there are several obstacles to this approach in the community college. Namely, many introductory level community college earth science courses have no mathematics prerequisites; as such, a typical classroom may include a wide range of mathematical skills and many students may be unable to participate in the analysis of “real” data. Further, reliable computer access to websites offering real-time data can be spotty at some institutions and for some students on home computers. In response to this problem we have created a multipart volcano monitoring activity based on the USGS Volcano Exploration Project: Pu`u `O`o (VEPP) website. This activity is designed for freshman or sophomore level courses in Introductory Geology or Geological Hazards for non-majors. No prior math skills are assumed; the activity can be completed without prior knowledge of GPS data, volcano monitoring or Hawaiian geology. The activity consists of three parts: (1) a background lecture on basic geology of volcanoes like Kilauea and use of GPS in volcano monitoring; (2) a lab activity or a homework assignment based on near real-time data downloaded from the VEPP website; and (3) a group wrap-up that focuses on real-time data by exploring other aspects of the VEPP website. The lab activity requires examination of downloaded GPS time series data for a specified time period (this can be modified as desired by the instructor), computation of displacements, graphing of displacement vectors for identified time intervals and determination of actual motion vectors, followed by a discussion of the displacements observed. These activities are interspersed by guided questions. This activity will be tested for the first time in Introductory Physical Geology courses at Pasadena City College during Fall 2010.

Measurement of the e+e-→KSKLπ0 cross section in the energy range √{s }=1.3 -2.0 GeV

NASA Astrophysics Data System (ADS)

Achasov, M. N.; Aulchenko, V. M.; Barnyakov, A. Yu.; Beloborodov, K. I.; Berdyugin, A. V.; Berkaev, D. E.; Bogdanchikov, A. G.; Botov, A. A.; Dimova, T. V.; Druzhinin, V. P.; Golubev, V. B.; Kardapoltsev, L. V.; Kasaev, A. S.; Kharlamov, A. G.; Kirpotin, A. N.; Koop, I. A.; Korneev, L. A.; Korol, A. A.; Kovrizhin, D. P.; Koshuba, S. V.; Kupich, A. S.; Melnikova, N. A.; Martin, K. A.; Obrazovsky, A. E.; Otboev, A. V.; Pakhtusova, E. V.; Pugachev, K. V.; Rogovsky, Yu. A.; Senchenko, A. I.; Serednyakov, S. I.; Silagadze, Z. K.; Shatunov, Yu. M.; Shtol, D. A.; Shwartz, D. B.; Surin, I. K.; Usov, Yu. V.; Vasiljev, A. V.

2018-02-01

The e+e-→KSKLπ0 cross section is measured in the center-of-mass energy range √{s }=1.3 - 2.0 GeV . The analysis is based on the data sample with an integrated luminosity of 33.5 pb-1 collected with the SND detector at the VEPP-2000 e+e- collider.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Kozyrev, E. A., E-mail: eakozyrev09@gmail.com; Akhmetshin, R. R.; Anisenkov, A. V.

Preliminary results of an experiment that is aimed at measuring the cross section for the process e{sup +}e{sup −} → K{sup +}K{sup −} at c.m. energies in the range between 1.01 and 2.0 GeV with the aid of the CMD-3 detector and which is being performed at the VEPP-2000 collider of the Budker Institute of Nuclear Physics (Novosibirsk, Siberian Branch, Russian Academy of Sciences) are presented.

Tensor Target Spin Asymmetries in Coherent π 0-Photoproduction on the Deuteron Including Intermediate η N N Interaction Within a Three-Body Approach

NASA Astrophysics Data System (ADS)

Darwish, Eed M.; Abou-Elsebaa, Hoda M.; Hassaneen, Khaled S. A.

2018-04-01

Motivated by the recent measurements from the VEPP-3 electron storage ring, we investigate the tensor target polarization asymmetries T 2 M ( M = 0, 1, 2) in the reaction γ d → π 0 d with a particular interest in the effect of the intermediate η N N three-body approach. This approach is based on realistic separable representations of the driving two-body interaction in the π N, η N, and NN subsystems. It is shown that the influence of rescattering effects in the intermediate state on the tensor target spin asymmetries is sizable at extreme backward pion angles. At forward angles, the contribution from the pure impulse approximation is dominated and the spin asymmetries show very little influence of rescattering effects. The sensitivity of results to the elementary pion photoproduction operator and to the NN potential model adopted for the deuteron wave function is investigated, and considerable dependences are found. The predicted spin asymmetries are also compared with available experimental data, and a satisfactory agreement with the recent data from VEPP-3 is obtained at photon energies below 400 MeV. At higher energies, the calculated spin asymmetries slightly underestimate the data.

The structure study of thin semiconductor and dielectric films by diffraction of synchrotron radiation

NASA Astrophysics Data System (ADS)

Yurjev, G. S.; Fainer, N. I.; Maximovskiy, E. A.; Kosinova, M. L.; Sheromov, M. A.; Rumyantsev, Yu. M.

1998-02-01

The structure of semiconductor and dielectric thin (100-300 nm) films was studied by diffraction of synchrotron radiation. The diffraction experiments were performed at both the station "Anomalous scattering" of the storage ring synchrotron facility VEPP-3 and DRON-4 diffractometer. The structure of CdS thin films grown on fused silica, single Si(100) and InP(100) substrates was investigated. The structure of Cu 2S thin films grown on fused silica, single Si(100) substrates and CdS/Si(100)-heterostructure was studied. The structure study was performed on Si 3N 4 films grown on GaAs(100) substrates. The structure of thin BN layers grown on single Si(100) substrates was studied. It was established that structural parameters of above-mentioned thin films coincide on the parameters of JCPDS International Centre for Diffraction Data.

Geochemical identification of mare-type basalt groups from a lunar highland region (by INAA and SRXFA)

NASA Astrophysics Data System (ADS)

Tarasov, L. S.; Kudryashova, A. F.; Ulyanov, A. A.; Baryshev, V. B.; Bobrov, V. A.; Shipitsyn, Yu. G.; Vertman, E. G.; Sudyko, A. F.

1989-10-01

The distribution of Rb, Sr, Y, Zr and Nb in 15 fragments of lunar mare-type basalt rocks from the Apollonius highland region has been investigated by the SRXFA method. The work has been carried out on the element analysis station of the storage ring VEPP-3. Preliminary identification of lunar rock groups was based on INAA data. Investigation by SRXFA permits to distinguish VLT-LT groups of basalts by geochemical criteria.

Measurement of the e + e - → ηK + K - Cross Section by Means of the SND Detector

NASA Astrophysics Data System (ADS)

Achasov, M. N.; Barnyakov, A. Yu.; Barnyakov, M. Yu.; Beloborodov, K. I.; Berdyugin, A. V.; Bogdanchikov, A. G.; Botov, A. A.; Buzykaev, A. R.; Vasiljev, A. V.; Golubev, V. B.; Dimova, T. V.; Druzhinin, V. P.; Zemlyansky, I. M.; Kardapoltsev, L. V.; Kovrizhin, D. P.; Korol, A. A.; Koshuba, S. V.; Kravchenko, E. A.; Kupich, A. S.; Lysenko, A. P.; Martin, K. A.; Melnikova, N. A.; Obrazovsky, A. E.; Onuchin, A. P.; Pakhtusova, E. V.; Perevedentsev, E. A.; Pugachev, K. V.; Skrinsky, A. N.; Serednyakov, S. I.; Silagadze, Z. K.; Surin, A. V.; Tikhonov, Yu. A.; Usov, Yu. V.; Kharlamov, A. G.; Shatunov, P. Yu.; Shatunov, Yu. M.; Shtol, D. A.

2018-03-01

The cross section for the process e + e - → ηK + K - wasmeasured at c.m. energies in the range between 1.56 and 2.00 GeV in an experiment with the SND detector at the VEPP-2000 e + e - collider. The invariant-mass distribution of kaon pairs is consistent with the hypothesis that the transition through the ηφ intermediate state makes a dominant contribution to the transition in question.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Lukin, P. A., E-mail: P.A.Lukin@inp.nsk.su; Anisenkov, A. V.; Aulchenko, V. M.

The cross sections for the processes e{sup +}e{sup −} → 2(π{sup +}π{sup −}π{sup 0}) and e{sup +}e{sup −} → 3(π{sup +}π{sup −}) at c.m. energies in the range of 1.5–2 GeV were measured with the aid of the CMD-3 detector at the VEPP-2000 collider of the Budker Institute of Nuclear Physics (Novosibirsk, Siberian Branch, Russian Academy of Sciences). The integrated luminosity in the respective experiment was 22 pb{sup −1}.

Summary of the Optics, IR, Injection, Operations, Reliability and Instrumentation Working Group

DOE Office of Scientific and Technical Information (OSTI.GOV)

Wienands, U.; /SLAC; Funakoshi, Y.

2012-04-20

The facilities reported on are all in a fairly mature state of operation, as evidenced by the very detailed studies and correction schemes that all groups are working on. First- and higher-order aberrations are diagnosed and planned to be corrected. Very detailed beam measurements are done to get a global picture of the beam dynamics. More than other facilities the high-luminosity colliders are struggling with experimental background issues, mitigation of which is a permanent challenge. The working group dealt with a very wide rage of practical issues which limit performance of the machines and compared their techniques of operations andmore » their performance. We anticipate this to be a first attempt. In a future workshop in this series, we propose to attempt more fundamental comparisons of each machine, including design parameters. For example, DAPHNE and KEKB employ a finite crossing angle. The minimum value of {beta}*{sub y} attainable at KEKB seems to relate to this scheme. Effectiveness of compensation solenoids and turn-by-turn BPMs etc. should be examined in more detail. In the near future, CESR-C and VEPP-2000 will start their operation. We expect to hear important new experiences from these machines; in particular VEPP-2000 will be the first machine to have adopted round beams. At SLAC and KEK, next generation B Factories are being considered. It will be worthwhile to discuss the design issues of these machines based on the experiences of the existing factory machines.« less

DOE Office of Scientific and Technical Information (OSTI.GOV)

Blunden, P. G.; Melnitchouk, W.

We examine the two-photon exchange corrections to elastic electron-nucleon scattering within a dispersive approach, including contributions from both nucleon and Δ intermediate states. The dispersive analysis avoids off-shell uncertainties inherent in traditional approaches based on direct evaluation of loop diagrams, and guarantees the correct unitary behavior in the high energy limit. Using empirical information on the electromagnetic nucleon elastic and NΔ transition form factors, we compute the two-photon exchange corrections both algebraically and numerically. Finally, results are compared with recent measurements of e + p to e - p cross section ratios from the CLAS, VEPP-3 and OLYMPUS experiments.

Management system for the SND experiments

NASA Astrophysics Data System (ADS)

Pugachev, K.; Korol, A.

2017-09-01

A new management system for the SND detector experiments (at VEPP-2000 collider in Novosibirsk) is developed. We describe here the interaction between a user and the SND databases. These databases contain experiment configuration, conditions and metadata. The new system is designed in client-server architecture. It has several logical layers corresponding to the users roles. A new template engine is created. A web application is implemented using Node.js framework. At the time the application provides: showing and editing configuration; showing experiment metadata and experiment conditions data index; showing SND log (prototype).

Cytopathic Effects of X-ray Irradiation and MnO Nanoparticles on Human Glioblastoma (U87)

NASA Astrophysics Data System (ADS)

Kuper, K. E.; Zavjalov, E. L.; Razumov, I. A.; Romaschenko, A. V.; Stupak, A. S.; Troicky, S. Yu; Goldenberg, B. G.; Legkodymov, A. G.; Lemzyakov, A. A.; Moshkin, M. P.

Glioblastoma is a leader among the most malignant brain tumors with the average lifespan of patients around 9-12 months. For prevention and treatment of neuropathology, a variety of therapeutic and surgical approaches are being developed and improved, including radiation and chemical therapy methods. In our work, we investigated cytopathic effect of X-ray irradiation with application of metal oxides nanoparticles such as manganese oxide (MnO) on U87 human glioblastoma cells. We used the X-ray irradiation dose of 0.5, 4, 40 and 100 Gy in combination with nanoparticles at the concentration of 0.5 ng/ml. The irradiation of glioma cell was carried out at the synchrotron radiation source VEPP-4. After cells treatments with nanoparticles for about 24 h and radiation the results were assessed by MTT assay test with 106/ml cells densities. We demonstrate that preincubation of the glioblastoma cell lines U87 with MnO nanoparticles allows reducing dose of irradiation. This combination of nanoparticles and X-ray irradiation provides new possibilities for the treatment of brain tumors.

Preliminary results of the cross-section measurement of e{sup +}e{sup −} → φ(1020)η process with the CMD-3 detector at VEPP-2000 collider

DOE Office of Scientific and Technical Information (OSTI.GOV)

Ivanov, V. L., E-mail: yacheslav-lvovich-ivanov@mail.ru; Akhmetshin, R. R.; Amirkhanov, A. N.

2016-03-15

We report preliminary results on the cross section of the process e{sup +}e{sup −} → φ(1020)η measured at 30 center-of-mass energy points in the range from 1.59 up to 2.0 GeV. Data analysis is based on the integrated luminosity of 22 pb{sup −1} collected with the CMD-3 detector in 2011–2012. The obtained cross section agrees with the BaBar measurement and has better statistical accuracy.

Investigation into Cherenkov light scattering and refraction on aerogel surface

NASA Astrophysics Data System (ADS)

Barnyakov, A. Yu.; Barnyakov, M. Yu.; Bobrovnikov, V. S.; Buzykaev, A. R.; Danilyuk, A. F.; Katcin, A. A.; Kirilenko, P. S.; Kononov, S. A.; Korda, D. V.; Kravchenko, E. A.; Kudryavtsev, V. N.; Kuyanov, I. A.; Onuchin, A. P.; Ovtin, I. V.; Podgornov, N. A.; Predein, A. Yu.; Prisekin, V. G.; Protsenko, R. S.; Shekhtman, L. I.

2017-12-01

The work concerns the development of aerogel radiators for RICH detectors. Aerogel tiles with a refractive index of 1.05 were tested with a RICH prototype on the electron beam on the VEPP-4M collider. It has been shown that polishing with silk tissue yields good surface quality, the amount of light loss at this surface being about 5-7%. The Cherenkov angle resolution was measured for a tile in two conditions: with a clean exit face and with a polished exit face. The number of photons detected was 13.3 and 12.7 for the clean and polished surfaces, respectively. The Cherenkov angle resolution for the polished surface is 55% worse, which can be explained with the forward scattering on the polished surface. A tile with a crack inside was also tested. The experimental data show that the Cherenkov angle resolution is the same for tracks crossing the crack area and in a crack-free area.

Measurement of X-ray mass attenuation coefficients in biological and geological samples in the energy range of 7-12keV.

PubMed

Trunova, Valentina; Sidorina, Anna; Kriventsov, Vladimir

2015-01-01

Information about X-ray mass attenuation coefficients in different materials is necessary for accurate X-ray fluorescent analysis. The X-ray mass attenuation coefficients for energy of 7-12keV were measured in biological (Mussel and Oyster tissues, blood, hair, liver, and Cabbage leaves) and geological (Baikal sludge, soil, and Alaskite granite) samples. The measurements were carried out at the EXAFS Station of Siberian Synchrotron Radiation Center (VEPP-3). Obtained experimental mass attenuation coefficients were compared with theoretical values calculated for some samples. Copyright © 2014 Elsevier Ltd. All rights reserved.

Dispersive approach to two-photon exchange in elastic electron-proton scattering

DOE PAGES

Blunden, P. G.; Melnitchouk, W.

2017-06-14

We examine the two-photon exchange corrections to elastic electron-nucleon scattering within a dispersive approach, including contributions from both nucleon and Δ intermediate states. The dispersive analysis avoids off-shell uncertainties inherent in traditional approaches based on direct evaluation of loop diagrams, and guarantees the correct unitary behavior in the high energy limit. Using empirical information on the electromagnetic nucleon elastic and NΔ transition form factors, we compute the two-photon exchange corrections both algebraically and numerically. Finally, results are compared with recent measurements of e + p to e - p cross section ratios from the CLAS, VEPP-3 and OLYMPUS experiments.

Using near-real-time monitoring data from Pu'u 'Ō'ō vent at Kīlauea Volcano for training and educational purposes

USGS Publications Warehouse

Teasdale, Rachel; Kraft, Katrien van der Hoeven; Poland, Michael P.

2015-01-01

Training non-scientists in the use of volcano-monitoring data is critical preparation in advance of a volcanic crisis, but it is currently unclear which methods are most effective for improving the content-knowledge of non-scientists to help bridge communications between volcano experts and non-experts. We measured knowledge gains for beginning-(introductory-level students) and novice-level learners (students with a basic understanding of geologic concepts) engaged in the Volcanoes Exploration Program: Pu‘u ‘Ō‘ō (VEPP) “Monday Morning Meeting at the Hawaiian Volcano Observatory” classroom activity that incorporates authentic Global Positioning System (GPS), tilt, seismic, and webcam data from the Pu‘u ‘Ō‘ō eruptive vent on Kīlauea Volcano, Hawai‘i (NAGT website, 2010), as a means of exploring methods for effectively advancing non-expert understanding of volcano monitoring. Learner groups consisted of students in introductory and upper-division college geology courses at two different institutions. Changes in their content knowledge and confidence in the use of data were assessed before and after the activity using multiple-choice and open-ended questions. Learning assessments demonstrated that students who took part in the exercise increased their understanding of volcano-monitoring practices and implications, with beginners reaching a novice stage, and novices reaching an advanced level (akin to students who have completed an upper-division university volcanology class). Additionally, participants gained stronger confidence in their ability to understand the data. These findings indicate that training modules like the VEPP: Monday Morning Meeting classroom activity that are designed to prepare non-experts for responding to volcanic activity and interacting with volcano scientists should introduce real monitoring data prior to proceeding with role-paying scenarios that are commonly used in such courses. The learning gains from the combined approach will help improve effective communications between volcano experts and non-experts during times of crisis, thereby reducing the potential for confusion and misinterpretation of data.

Measurement of the Asymmetry of Photoproduction of π- Mesons on Linearly Polarized Deuterons by Linearly Polarized Photons

NASA Astrophysics Data System (ADS)

Gauzshtein, V. V.; Zevakov, S. A.; Levchuk, M. I.; Loginov, A. Yu.; Nikolenko, D. M.; Rachek, I. A.; Sadykov, R. Sh.; Toporkov, D. K.; Shestakov, Yu. V.

2018-05-01

The first results of a double polarization experiment to extract the asymmetry of the reaction of photoproduction of a π- meson by a linearly polarized photon on a tensor-polarized deuteron in the energy range of the virtual photon (300-700 MeV) are presented. The measurements were performed on an internal tensor-polarized deuterium target in the VEPP-3 electron-positron storage ring for the electron beam energy equal to 2 GeV. The experiment employed the method of recording two protons and the scattered electron in coincidence. The obtained measurement results are compared with the theoretical predictions obtained in the momentum approximation with allowance for πN and NN rescattering in the final state.

Status of the experiment for the search of a dark photon at VEPP–3

DOE Office of Scientific and Technical Information (OSTI.GOV)

Rachek, Igor; Nikolenko, Dmitri; Wojtsekhowski, Bogdan B.

2017-04-12

The status of the experiment to search for a new gauge boson, A', in e +e - annihilation by means of a positron beam incident on a gas hydrogen target internal to the bypass at the VEPP-3 storage ring is reported. The search method is based on a missing mass spectra in reaction e +e - → γA'. It allows observation of the A' signal independently of its decay modes and life time. The projected result of this experiment corresponds to an upper limit on the square of coupling constant ε 2 = (0.2 ÷ 1.0) · 10 -7 withmore » a signal-to-noise ratio of two to one at A' mass of 5–20 MeV.« less

Searching for dark photon with positrons at Jefferson lab

NASA Astrophysics Data System (ADS)

Marsicano, Luca

2018-05-01

The interest in the Dark Photon (A' or U) has recently grown, since it could act as a light mediator to a new sector of Dark Matter particles. In this paradigm, the electron-positron annihilation can rarely produce a γA' pair. Various experiments (e.g. PADME@LNF [1], VEPP-3 [2]) have been proposed to detect this process using positron beams impinging on fixed targets. In such experiments, the energy of the photon from the e+e-→ γA' process is measured with an electromagnetic calorimeter and the missing mass is computed (the A' interacts weakly with Standard Model matter so it can't be detected). However, the A' mass range that can be explored with this technique is limited by the accessible energy in the center of mass frame, which goes as the square root of the beam energy. The realization of a 11 GeV positron beam at Jefferson Lab would allow to search for A' masses up to ˜ 100 MeV, reaching unexplored regions of the A' parameter space. A preliminary study on the feasibility of a PADME-like experiment at Jefferson Lab has been carried out, assuming a 11 GeV positron beam with a ˜ 100 nA current. The achievable sensitivity was estimated, studying the main sources of background (positron bremsstrahlung, annihilation into 2 gammas) using CALCHEP [3] and GEANT4 [4] simulations.

SRXRF Study of Chemical Elements Content in the Atherosclerotic Plaque of Heart Vessels

NASA Astrophysics Data System (ADS)

Zhuravskaya, E. Ya.; Savchenko, T. I.; Chankina, O. V.; Polonskaya, Ya. V.; Chernyavskii, A. M.; Ragino, Yu. I.; Shcherbakova, L. V.

The SRXRF method has made it possible, for the first time, to determine the multielement composition in the atherosclerotic substrates of heart vessels after surgical interventions. The main advantage of the method is the possibility to analyze small samples without their destruction. As the amount of material to test is insufficient, we have developed a special technique for sample preparation. The concentrations of K, Ca, Cr, Mn, Fe, Co, Ni, Cu, Zn, Br, Sr, Zr, and Pb were measured in stable and unstable plaques. In all the samples studied, Ca is dominating, particularly, in the unstable plaque. No reliable difference was established for other elements measured. A high degree of the association of Ca with Fe, Zn and Sr has been revealed in the atherosclerotic plaques. Measurements were performed using SR from the VEPP-3 storage ring.

Experiment Management System for the SND Detector

NASA Astrophysics Data System (ADS)

Pugachev, K.

2017-10-01

We present a new experiment management system for the SND detector at the VEPP-2000 collider (Novosibirsk). An important part to report about is access to experimental databases (configuration, conditions and metadata). The system is designed in client-server architecture. User interaction comes true using web-interface. The server side includes several logical layers: user interface templates; template variables description and initialization; implementation details. The templates are meant to involve as less IT knowledge as possible. Experiment configuration, conditions and metadata are stored in a database. To implement the server side Node.js, a modern JavaScript framework, has been chosen. A new template engine having an interesting feature is designed. A part of the system is put into production. It includes templates dealing with showing and editing first level trigger configuration and equipment configuration and also showing experiment metadata and experiment conditions data index.

Prediction of e± elastic scattering cross-section ratio based on phenomenological two-photon exchange corrections

NASA Astrophysics Data System (ADS)

Qattan, I. A.

2017-06-01

I present a prediction of the e± elastic scattering cross-section ratio, Re+e-, as determined using a new parametrization of the two-photon exchange (TPE) corrections to electron-proton elastic scattering cross section σR. The extracted ratio is compared to several previous phenomenological extractions, TPE hadronic calculations, and direct measurements from the comparison of electron and positron scattering. The TPE corrections and the ratio Re+e- show a clear change of sign at low Q2, which is necessary to explain the high-Q2 form factors discrepancy while being consistent with the known Q2→0 limit. While my predictions are in generally good agreement with previous extractions, TPE hadronic calculations, and existing world data including the recent two measurements from the CLAS and VEPP-3 Novosibirsk experiments, they are larger than the new OLYMPUS measurements at larger Q2 values.

Energy conversion of X-ray, ultraviolet and infrared radiation in Gd2O3 crystals doped with Er3+ ions

NASA Astrophysics Data System (ADS)

Trofimova, E. S.; Pustovarov, V. A.; Kuznetsova, Yu. A.; Zatsepin, A. F.

2017-09-01

Spectra of photoluminescence (PL) and X-ray excited luminescence (XRL) in region of 1.5-5.0 eV, PL excitation spectra (2.8-5.8 eV), PL decay kinetics were measured in Gd2O3 crystals doped both with Er3+ and Zn2+ ions. Synchrotron radiation (VEPP-3 storage ring, Novosibirsk, Russia) were used for XRL measurements. PL spectra were studied at room temperature and T= 88 K under excitation with energy Eexc: a) in fundamental absorption region (Eexc≥Eg); b) in intracenter excitation region (Eexc

Limits of a spatial resolution of the cascaded GEM based detectors

NASA Astrophysics Data System (ADS)

Kudryavtsev, V. N.; Maltsev, T. V.; Shekhtman, L. I.

2017-06-01

Spatial resolution of tracking detectors based on GEM cascades is determined in the simulation and measured. The simulation includes GEANT4 implemented transport of high energy electrons with careful accounting for atomic relaxation processes including emission of fluorescent photons and Auger electrons and custom post-processing taking into account diffusion, gas amplification fluctuations, the distribution of signals over readout electrodes, electronics noise and particular algorithm of final coordinate calculation (centre-of-gravity algorithm). The simulation demonstrates that the minimum of the spatial resolution of about 10-20 μm can be achieved with a gas mixture of Ar-CO2 (75%-25%) at a strip pitch in the range from 250 μm to 300 μm. At a larger pitch the resolution quickly degrades reaching 70-100 μm at a pitch of 450-500 μm. The reasons of such behavior are discussed and corresponding hypothesis is tested. Particularly, the effect of electron cloud modification due to a GEM operation is considered using the ANSYS and Garfield++ simulation programs. The detection efficiency and spatial resolution of low-material triple-GEM detectors for the DEUTERON facility at BINP are measured at the extracted beam facility of the VEPP-4M collider. One-coordinate resolution of two detectors for the DEUTERON facility is measured with a 2 GeV electron beam. The determined values of the detectors' spatial resolution is equal to 46.6 ± 0.1 μm and 38.5 ± 0.2 μm for orthogonal tracks in two detectors, respectively.

Workshop on Pion-Kaon Interactions (PKI2018) Mini-Proceedings

DOE Office of Scientific and Technical Information (OSTI.GOV)

Amaryan, M; Pal, Bilas

This volume is a short summary of talks given at the PKI2018 Workshop organized to discuss current status and future prospects of pi -K interactions. The precise data on pi K interaction will have a strong impact on strange meson spectroscopy and form factors that are important ingredients in the Dalitz plot analysis of a decays of heavy mesons as well as precision measurement of Vus matrix element and therefore on a test of unitarity in the first raw of the CKM matrix. The workshop has combined the efforts of experimentalists, Lattice QCD, and phenomenology communities. Experimental data relevant tomore » the topic of the workshop were presented from the broad range of different collaborations like CLAS, GlueX, COMPASS, BaBar, BELLE, BESIII, VEPP-2000, and LHCb. One of the main goals of this workshop was to outline a need for a new high intensity and high precision secondary KL beam facility at JLab produced with the 12 GeV electron beam of CEBAF accelerator.« less

Evolution of the Virtualized HPC Infrastructure of Novosibirsk Scientific Center

NASA Astrophysics Data System (ADS)

Adakin, A.; Anisenkov, A.; Belov, S.; Chubarov, D.; Kalyuzhny, V.; Kaplin, V.; Korol, A.; Kuchin, N.; Lomakin, S.; Nikultsev, V.; Skovpen, K.; Sukharev, A.; Zaytsev, A.

2012-12-01

Novosibirsk Scientific Center (NSC), also known worldwide as Akademgorodok, is one of the largest Russian scientific centers hosting Novosibirsk State University (NSU) and more than 35 research organizations of the Siberian Branch of Russian Academy of Sciences including Budker Institute of Nuclear Physics (BINP), Institute of Computational Technologies, and Institute of Computational Mathematics and Mathematical Geophysics (ICM&MG). Since each institute has specific requirements on the architecture of computing farms involved in its research field, currently we've got several computing facilities hosted by NSC institutes, each optimized for a particular set of tasks, of which the largest are the NSU Supercomputer Center, Siberian Supercomputer Center (ICM&MG), and a Grid Computing Facility of BINP. A dedicated optical network with the initial bandwidth of 10 Gb/s connecting these three facilities was built in order to make it possible to share the computing resources among the research communities, thus increasing the efficiency of operating the existing computing facilities and offering a common platform for building the computing infrastructure for future scientific projects. Unification of the computing infrastructure is achieved by extensive use of virtualization technology based on XEN and KVM platforms. This contribution gives a thorough review of the present status and future development prospects for the NSC virtualized computing infrastructure and the experience gained while using it for running production data analysis jobs related to HEP experiments being carried out at BINP, especially the KEDR detector experiment at the VEPP-4M electron-positron collider.

Experimental Modeling of the Impulse Diffraction System with a "White" SR Beam

NASA Astrophysics Data System (ADS)

Fedotov, M. G.; Aleshaev, A. N.

Some matrix detectors (CCD and CIS) have direct X-ray sensitivity and can operate as dispersionless spectrometers with a very large number of elements (106 and more). In the case of the impulse diffraction such detector can simultaneously record a significant number of independent events. In the reading the position and energy of the absorbed X-ray photon may be restored for each event. The mathematical processing of the received data with respect to the Bragg condition can theoretically lead to the coordinates of the events of one fixed energy and to form an analogue of powder diffraction patterns. In this case the registration can be performed on the "white" SR beam for a short time (up to 1 ns or less). The possibility of using of the 2000-element linear CCD ILX511 (Sony) as X-ray dispersionless spectrometer allowed to conduct simulation experiments to obtain diffraction patterns of graphite, boron nitride, boric acid and TNT-hexogen solid detonation products. SR beam from VEPP-3 storage ring was modulated by a mechanical chopper and statistics were provided by a multiple recording with on-line processing.

Development of a silicon microstrip detector with single photon sensitivity for fast dynamic diffraction experiments at a synchrotron radiation beam

NASA Astrophysics Data System (ADS)

Arakcheev, A.; Aulchenko, V.; Kudashkin, D.; Shekhtman, L.; Tolochko, B.; Zhulanov, V.

2017-06-01

Time-resolved experiments on the diffraction of synchrotron radiation (SR) from crystalline materials provide information on the evolution of a material structure after a heat, electron beam or plasma interaction with a sample under study. Changes in the material structure happen within a microsecond scale and a detector with corresponding parameters is needed. The SR channel 8 of the VEPP-4M storage ring provides radiation from the 7-pole wiggler that allows to reach several tens photons within one μs from a tungsten crystal for the most intensive diffraction peak. In order to perform experiments that allow to measure the evolution of tungsten crystalline structure under the impact of powerful laser beam, a new detector is developed, that can provide information about the distribution of a scattered SR flux in space and its evolution in time at a microsecond scale. The detector is based on the silicon p-in-n microstrip sensor with DC-coupled metal strips. The sensor contains 1024 30 mm long strips with a 50 μm pitch. 64 strips are bonded to the front-end electronics based on APC128 ASICs. The APC128 ASIC contains 128 channels that consist of a low noise integrator with 32 analogue memory cells each. The integrator equivalent noise charge is about 2000 electrons and thus the signal from individual photons with energy above 40 keV can be observed. The signal can be stored at the analogue memory with 10 MHz rate. The first measurements with the beam scattered from a tungsten crystal with energy near 60 keV demonstrated the capability of this prototype to observe the spatial distribution of the photon flux with the intensity from below one photon per channel up to 0~10 photons per channel with a frame rate from 10 kHz up to 1 MHz.

Global warming stops in Altai and Northern Mongolia in 2010-2015.

NASA Astrophysics Data System (ADS)

Darin, A.; Kalugin, I.; Maksimov, M.

2010-03-01

We studied the cores of bottom sediments of Lake Teletskoe (Mountain Altai) [1] and Lake Telmen (Northern Mongolia) [2]. The method of constructing the forecast includes the following steps: 1) Geochemical analysis of lakes bottom sediment cores with spatial resolution 0.1 mm using synchrotron radiation [3]. It corresponds to the time resolution ~ 0.2-0.3 year (sedimentation rates are equal 0.51 mm/year for Teletskoe Lake and 0.64 mm/year for Telmen Lake). 2) Creating a time series of geochemical indicators of climate change.We used the following geochemical proxies: Ti, Br, Rb, Sr, Mo contents and X-ray density. 3) Calibration transfer functions on the regional meteodata during the last 80-120 years. Regression equation such as: annual T = function (proxy) were calculated. 4) Reconstruction of climatic parameters on the depth of the core. Annual temperature change for the Altai region (0 - 3000 years ago) and Northern Mongolia region (0 - 2000 years ago) have been reconstructed with time resolution ~ 0.2-0.3 year. 5) A Fourier analysis showed the same frequency of climate change for both regions. Have been identified as the main periods (frequency): 2750, 1500, 1015, 825, 615, 500, 375, 325, 290, 230, 215, 203, 190, 157, 135, 109, 88, 65, 48, 37, 24 and 10 years. The sum of 22 sinusoid correlates with the reconstruction of annual temperature with the coefficient +0.87 (for more than 3000 points). 6) Based on the discovered periodicities forecast the environment change for the period 2010-2050 was calculated. According to our estimates at this time is expected sharp fall of annual regional temperature. The study was funded by grant 09-05-13505 from the Russian Foundation for Basic Research, by grant 92 from the Siberian Branch of the Russian Academy of Sciences. [1] I.A.Kalugin et all. Rhythmic fine-grained sediment deposition in Lake Teletskoye... Quaternary International, 136 (2005), 5-13. [2] S. J. Fowell et all. Mid to late Holocene climate evolution of the Lake Telmen Basin . . . // Quaternary Research 59 (2003) 353-363 [3] A. Daryin et all. Use of a scanning XRF analysis on SR beams from VEPP-3 storage ...// Nucl. Instrum. and Methods in Physics Research A 543 (2005) 255-258.

List of Posters

NASA Astrophysics Data System (ADS)

List of Posters: Dark matter annihilation in the Galactic galo, by Dokuchaev Vyacheslav, et al. NEMO developments towards km3 telescope in the Mediterranean Sea. The NEMO project. Neutrino Mediterranean Observatory By Antonio Capone, NEMO Collaboration. Alignment as a result from QCD jet production or new still unknown physics at LHC? By Alexander Snigirev. Small-scale fluctuations of extensive air showers: systematics in energy and muon density estimation By Grigory Rubtsov. SHINIE: Simulation of High-Energy Neutrino Interacting with the Earth By Lin Guey-Lin, et al.. Thermodynamics of rotating solutions in n+1 dimensional Einstein - Maxwell -dilation gravity By Ahmad Sheykhi, et al.. Supernova neutrino physics with future large Cherenkov detectors By Daniele Montanino. Crossing of the Cosmological Constant Barrier in the string Inspired Dark Energy Model By S. Yu. Vernov. Calculations of radio signals produced by ultra-high and extremely high energy neutrino induced cascades in Antarctic ice By D. Besson, et al.. Inflation, Cosmic Acceleration and string Gravity By Ischwaree Neupane. Neutrino Physics: Charm and J/Psi production in the atmosphere By Liudmila Volkova. Three generation flavor transitions and decays of supernova relic neutrinos By Daniele Montanino. Lattice calculations & computational quantum field theory: Sonification of Quark and Baryon Spectra By Markum Harald, et al.. Generalized Kramers-Wannier Duality for spin systems with non-commutative symmetry By V. M. Buchstaber, et al.. Heavy ion collisions & quark matter: Nuclear matter jets and multifragmentation By Danut Argintaru, et al.. QCD hard interactions: The qT-spectrum of the Higgs and Slepton-pairs at the LHC By Guiseppe Bozzi. QCD soft interactions: Nonperturbative effects in Single-Spin Asymmetries: Instantons and TMD-parton distributions By Igor Cherednikov, et al.. Gluon dominance model and high multiplicity By Elena Kokoulina. Resonances in eta pi- pi- pi+ system By Dmitry Ryabchikov. Saturation effects in diffractive scattering at LHC By Oleg Selugin. A nonperturbative expansion method in QCD and R-related quantities By Igor Solovtsov. Z-scaling and high multiplicity particle Production in bar pp/pp & AA collisions at Tevatron and RHIC By Mikhail Tokarev. Scaling behaviour of the reactionsdd - > p↑ /3H and pd - > pd with pT at energy I-2 GeV By Yuri Uzikov. [ADS Note: Title formula can not be rendered correctly in ASCII.] CP violation, rare decays, CKM: Precision Measurements of the Mass of the Top Quark at CDF (Precision Top Mass Measurements at CDF) By Daniel Whiteson. Measurement of the Bs Oscillation at CDF By Luciano Ristori. The Bs mixing phase at LHCb By J. J. van Hunen. ATLAS preparations for precise measurements of semileptonic rare B decays By K. Toms. Hadron spectroscopy & exotics: Searches for radial excited states of charmonium in experiments using cooled antiproton beams By M. Yu. Barabanov. Retardation effects in the rotating string model By Fabien Buisseret and Claude Semay. Final results from VEPP-2M (CMD-2 and SND) By G. V. Fedotovich. Heavy Quark Physics: Prospects for B physics measurements using the CMS detector at the LHC By Andreev Valery. Heavy flavour production at HERA-B By Andrey Bogatyrev. B-Meson subleading form factors in the Heavy Quark Effective Theory (HQET) By Frederic Jugeau. Beyond the Standard Model: Monopole Decay in a Variable External Field By Andrey Zayakin. Two-Loop matching coefficients for the strong coupling in the MSSM By Mihaila Luminita. Test of lepton flavour violation at LHC By Hidaka Keisho. Looking at New Physics through 4 jets and no ET By Maity Manas. Are Preons Dyons? Naturalness of Three Generations By Das Chitta Ranjan. SUSY Dark Matter at Linear Collider By Sezen Sekmen, Mehmet Zeyrek. MSSM light Higgs boson scenario and its test at hadron colliders By Alexander Belyaev. Antiscalar Approach to Gravity and Standard Model By E. Mychelkin. GRID distributed analysis in high energy physics: PAX: Physics Analysis Design and Application on the GRID By Martin Erdmann, et al.. D0 and the (SAM) GRID: An ongoing success story DO Collaboration. R & D for future accelerators, detectors & new facilities: High Level Trigger Selection in the CMS experiment By Monica Vazquez Acosta. R&D for a Helical Undulator Based Positron Source for the International Linear Collider By Phil Allport. Muon Detection, Reconstruction and Identification in CMS By Ivan Belotelov. Acoustic Measurements for EeV Neutrino Detection at the South Pole By Sebastian Böser. The PSI source of ultracold neutrons (UCN) By Manfred Daum. The LHCb Pixel Hybrid Photon Detectors (Characterization of Nybrig Photon Detectors for the LHCb experiment) By Neville Harnew, et al.. Semi-Insulating GaN-radiation hard semiconductor for ionizing radiation detectors By Juozas Vaitkus. Monitored Drift Tube end-cap spectrometer for the ATLAS detector By Dmitri Kotchetkov. Development of Focusing Aerogel RICH By Sergey Kononov, et al.. Electromagnetic Calibration of the Hadronic Tile Calorimeter Modules of the ATLAS detector at the LHC By Iouri Koultchitski. A Study of Proximity focusing RICH with Multiple Refractive Index Aerogel Radiator By Peter Krizan. The Heavy Flavor Tracker (HFT) for STAR By Vasil Kuspil. ATLAS Liquid Argon Calorimeter ATLAS Collaboration: Field Emission in HEP Colliders Initiated by a Relativistic Positively Charged Bunch of Particles By Boris Levchenko. MICE: the international Muon Ionization Cooling Experiment By Kenneth Long. In situ calibration of the CMS electromagnetic calorimeter By Augustino Lorenzo. The Transition Radiation Tracker for the ATLAS experiment at the LHC By Victor Maleev. Resonance depolarization and Compton-Backscattering technique for beam energy measurement of VEPP-4M collider By Ivan Nikolaev, et al.. CCD - based Pixel Detectors by LCFI By Andrei Nomerotski. The SiD Detector Concept for the International Linear Collider By Dmitry Onoprienko. CMS Hadron Calorimetry, Calibration, and Jets/Missing Transverse Energy Measurements By Sergey Petrushanko. The CMS Silicon Tracker By Oliver Pooth. Drift Chamber for CMD-3 detector By Alexandr Popov, et al.. Vacuum Phototriods for the CMS ECAL Endcap crystal calorimeter By Vladimir Postoev. CMS Silicon Tracker: Track Reconstruction and Alignment By Frank-Peter Schilling. eRHIC - A precision electron-proton/ion collider facility at Brookhaven National Laboratory By Bernd Surrow. Development of tracking detectors with industrially produced GEM foils By Bernd Surrow, et al.. A Linear Collider Facility with High Intensity e+e- beams (A high intensity e+e- Linear Collider Facility at low energy) By Andre Schoening. Construction of the BESIII detector for tau-charm physics By Yifang Wang. The HERMES Recoil Detector By Sergey Yashchenko. Simulation of MICE in G4 MICE MICE Experiment: The new DO Layer O silicon detector The DO trigger upgrade for RUNIIb The Do Collaboration. Operational experiences with the silicon detector at CDF By Jeannine Wagner. Mathematical aspects of QFT & string theory: Electron in superstrong Coulomb field By D. Gitman. Stability of a non-commutative Jackiw-Teitelboim gravity By Fresneda Rodrigo, et al.. 4d gravity localized on thick branes: the complete mass spectrum By Alfredo Herrera-Aguilar. On Emergence of Quantum Mechanics By L. V. Prokhorov.

Measurement of two-photon exchange effect by comparing elastic e ± p cross sections

DOE PAGES

Rimal, D.; Adikaram, D.; Raue, B. A.; ...

2017-06-01

Background: The electromagnetic form factors of the proton measured by unpolarized and polarized electron scattering experiments showa significant disagreement that grows with the squared four-momentum transfer (Q(2)). Calculations have shown that the two measurements can be largely reconciled by accounting for the contributions of two-photon exchange (TPE). TPE effects are not typically included in the standard set of radiative corrections since theoretical calculations of the TPE effects are highly model dependent, and, until recently, no direct evidence of significant TPE effects has been observed. Purpose: We measured the ratio of positron-proton to electron-proton elastic-scattering cross sections in order to determinemore » the TPE contribution to elastic electron-proton scattering and thereby resolve the proton electric form factor discrepancy. Methods: We produced a mixed simultaneous electron-positron beam in Jefferson Lab's Hall B by passing the 5.6-GeV primary electron beam through a radiator to produce a bremsstrahlung photon beam and then passing the photon beam through a convertor to produce electron-positron pairs. The mixed electron-positron (lepton) beam with useful energies from approximately 0.85 to 3.5 GeV then struck a 30-cm-long liquid hydrogen (LH2) target located within the CEBAF Large Acceptance Spectrometer (CLAS). By detecting both the scattered leptons and the recoiling protons, we identified and reconstructed elastic scattering events and determined the incident lepton energy. A detailed description of the experiment is presented. Results: We present previously unpublished results for the quantity R-2 gamma, the TPE correction to the elastic-scattering cross section, at Q(2) approximate to 0.85 and 1.45 GeV2 over a large range of virtual photon polarization epsilon. Conclusions: Our results, along with recently published results from VEPP-3, demonstrate a nonzero contribution from TPE effects and are in excellent agreement with the calculations that include TPE effects and largely reconcile the form-factor discrepancy up to Q(2) approximate to 2 GeV2. These data are consistent with an increase in R-2 gamma. with decreasing e at Q(2) approximate to 0.85 and 1.45 GeV2. There are indications of a slight increase in R-2 gamma with Q(2).« less

Measurement of two-photon exchange effect by comparing elastic e±p cross sections

NASA Astrophysics Data System (ADS)

Rimal, D.; Adikaram, D.; Raue, B. A.; Weinstein, L. B.; Arrington, J.; Brooks, W. K.; Ungaro, M.; Adhikari, K. P.; Afanasev, A. V.; Akbar, Z.; Pereira, S. Anefalos; Badui, R. A.; Ball, J.; Baltzell, N. A.; Battaglieri, M.; Batourine, V.; Bedlinskiy, I.; Biselli, A. S.; Boiarinov, S.; Briscoe, W. J.; Bültmann, S.; Burkert, V. D.; Carman, D. S.; Celentano, A.; Chetry, T.; Ciullo, G.; Clark, L.; Colaneri, L.; Cole, P. L.; Compton, N.; Contalbrigo, M.; Cortes, O.; Crede, V.; D'Angelo, A.; Dashyan, N.; De Vita, R.; Deur, A.; Djalali, C.; Dupre, R.; Egiyan, H.; Alaoui, A. El; Fassi, L. El; Eugenio, P.; Fanchini, E.; Fedotov, G.; Fersch, R.; Filippi, A.; Fleming, J. A.; Forest, T. A.; Fradi, A.; Gevorgyan, N.; Ghandilyan, Y.; Gilfoyle, G. P.; Giovanetti, K. L.; Girod, F. X.; Gleason, C.; Gohn, W.; Golovatch, E.; Gothe, R. W.; Griffioen, K. A.; Guo, L.; Hafidi, K.; Hanretty, C.; Harrison, N.; Hattawy, M.; Heddle, D.; Hicks, K.; Holtrop, M.; Hughes, S. M.; Ilieva, Y.; Ireland, D. G.; Ishkhanov, B. S.; Isupov, E. L.; Jenkins, D.; Jiang, H.; Joosten, S.; Keller, D.; Khachatryan, G.; Khandaker, M.; Kim, W.; Klein, A.; Klein, F. J.; Kubarovsky, V.; Kuhn, S. E.; Kuleshov, S. V.; Lanza, L.; Lenisa, P.; Livingston, K.; Lu, H. Y.; MacGregor, I. J. D.; Markov, N.; McKinnon, B.; Mestayer, M. D.; Mirazita, M.; Mokeev, V.; Movsisyan, A.; Munevar, E.; Camacho, C. Munoz; Nadel-Turonski, P.; Ni, A.; Niccolai, S.; Niculescu, G.; Niculescu, I.; Osipenko, M.; Ostrovidov, A. I.; Paolone, M.; Paremuzyan, R.; Park, K.; Pasyuk, E.; Phelps, W.; Pisano, S.; Pogorelko, O.; Price, J. W.; Prok, Y.; Protopopescu, D.; Puckett, A. J. R.; Rizzo, A.; Rosner, G.; Rossi, P.; Roy, P.; Sabatié, F.; Salgado, C.; Schumacher, R. A.; Seder, E.; Sharabian, Y. G.; Skorodumina, Iu.; Smith, G. D.; Sokhan, D.; Sparveris, N.; Stankovic, Ivana; Stepanyan, S.; Strauch, S.; Sytnik, V.; Taiuti, M.; Torayev, B.; Voskanyan, H.; Voutier, E.; Walford, N. K.; Watts, D. P.; Wei, X.; Wood, M. H.; Zachariou, N.; Zana, L.; Zhang, J.; Zhao, Z. W.; Zonta, I.; CLAS Collaboration

2017-06-01

Background: The electromagnetic form factors of the proton measured by unpolarized and polarized electron scattering experiments show a significant disagreement that grows with the squared four-momentum transfer (Q2). Calculations have shown that the two measurements can be largely reconciled by accounting for the contributions of two-photon exchange (TPE). TPE effects are not typically included in the standard set of radiative corrections since theoretical calculations of the TPE effects are highly model dependent, and, until recently, no direct evidence of significant TPE effects has been observed. Purpose: We measured the ratio of positron-proton to electron-proton elastic-scattering cross sections in order to determine the TPE contribution to elastic electron-proton scattering and thereby resolve the proton electric form factor discrepancy. Methods: We produced a mixed simultaneous electron-positron beam in Jefferson Lab's Hall B by passing the 5.6-GeV primary electron beam through a radiator to produce a bremsstrahlung photon beam and then passing the photon beam through a convertor to produce electron-positron pairs. The mixed electron-positron (lepton) beam with useful energies from approximately 0.85 to 3.5 GeV then struck a 30-cm-long liquid hydrogen (LH2) target located within the CEBAF Large Acceptance Spectrometer (CLAS). By detecting both the scattered leptons and the recoiling protons, we identified and reconstructed elastic scattering events and determined the incident lepton energy. A detailed description of the experiment is presented. Results: We present previously unpublished results for the quantity R2 γ, the TPE correction to the elastic-scattering cross section, at Q2≈0.85 and 1.45 GeV2 over a large range of virtual photon polarization ɛ . Conclusions: Our results, along with recently published results from VEPP-3, demonstrate a nonzero contribution from TPE effects and are in excellent agreement with the calculations that include TPE effects and largely reconcile the form-factor discrepancy up to Q2≈2 GeV2 . These data are consistent with an increase in R2 γ with decreasing ɛ at Q2≈0.85 and 1.45 GeV2. There are indications of a slight increase in R2 γ with Q2.

All Prime Contract Awards by State or Country, Place, and Contractor, FY 88. Part 6. (Alachua, Florida-Woodstock, Georgia).

DTIC Science & Technology

1988-01-01

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All Prime Contract Awards by State or Country, Place, and Contractor, FY 88. Part 3. (Lomita, California-San Bernardino, California).

DTIC Science & Technology

1988-01-01

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Prime Contract Awards Alphabetically by Contractor, by State or Country, and Place, FY 88. Part 19. (Synertech Associates, Inc.-Tucker Equipment Co., Inc.)

DTIC Science & Technology

1988-01-01

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Prime Contract Awards Alphabetically by Contractor, by State or Country, and Place, FY 88. Part 21. (VVKR Incorporated-Zymed, Inc.)

DTIC Science & Technology

1988-01-01

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Sensitization and cross-reactivity patterns of contact allergy to diisocyanates and corresponding amines: investigation of diphenylmethane-4,4'-diisocyanate, diphenylmethane-4,4'-diamine, dicyclohexylmethane-4,4'-diisocyanate, and dicylohexylmethane-4,4'-diamine.

PubMed

Hamada, Haneen; Bruze, Magnus; Zimerson, Erik; Isaksson, Marléne; Engfeldt, Malin

2017-10-01

Isocyanates are used in polyurethane production. Dermal exposure to isocyanates can induce contact allergy. The most common isocyanate is diphenylmethane diisocyanate used for industrial purposes. The isomer diphenylmethane-4,4'-diisocyanate (4,4'-MDI) is used in patch testing. Diphenylmethane-4,4'-diamine (4,4'-MDA) is its corresponding amine. Concurrent reactions to 4,4'-MDI and 4,4'-MDA have been reported, as have concurrent reactions to 4,4'-MDI and dicyclohexylmethane-4,4'-diisocyanate (4,4'-DMDI). To investigate the sensitization capacities and the cross-reactivity of 4,4'-MDI, 4,4'-MDA, 4,4'-DMDI, and dicyclohexylmethane-4,4'-diamine (4,4'-DMDA). The guinea-pig maximization test (GPMT) was used. The GPMT showed sensitizing capacities for all investigated substances: 4,4'-MDI, 4,4'-MDA, 4,4'-DMDI, and 4,4'-DMDA (all p < 0.001). 4,4'-MDI-sensitized animals showed cross-reactivity to 4,4'-MDA (p < 0.001) and 4,4'-DMDI (all p < 0.05). 4,4'-MDA-sensitized animals showed cross-reactivity to 4,4'-DMDA (p = 0.008). All of the investigated substances were shown to be strong sensitizers. Animals sensitized to 4,4'-MDI showed cross-reactivity to 4,4'-MDA and 4,4'-DMDI, supporting previous findings in the literature. The aromatic amine 4,4'-MDA showed cross-reactivity to the aliphatic amine 4,4'-DMDA. © 2017 The Authors. Contact Dermatitis published by John Wiley & Sons Ltd.

Department of Defense Prime Contracts over $25,000 for Services. Fiscal Year 1992. Part 1 (B502 AJT & Associates Inc-J999 Xerox Corp)

DTIC Science & Technology

1993-01-01

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Official Guard and Reserve Manpower Strengths and Statistics, FY 1985 Summary

DTIC Science & Technology

1985-01-01

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Prime Contract Awards by State or Country, Place and Contractor. Part 14 (West Warwick, Rhode Island - Katy, Texas), FY1991

DTIC Science & Technology

1991-01-01

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Anthropometry of Women of the U.S. Army--1977. Report Number 3. Bivariate Frequency Tables

DTIC Science & Technology

1977-07-01

U4 (\\ 4. 4 (I ’ a -1 Or L - l CLJ U. L. C.)~V * . -4 W- (V (N 4 ’ ( .4~-. U., 𔃾 (- L4+ + LU. B S- AV ILBL UOYu rr~ 4.4 4~4 4~) 4- - flJ 41.4 -J 4...0 4 ^* 04L I I 4 x v0 -- 4.44- . 4- 4. . 4- 4. 4 411 I~tfl \\Jr4(A 0 N~LI S 19 Id -4 o ,4 UNN6 A NI t4 . I P.. A 4N ,j td t󈧄’- 4 (v. LA In .4 10...J %. td 0A I.- 𔃾 0 - 40 CI (TIU LA m r N?)MLA 4 0% x > co ~ r" (M -4- ) 4 (A Li * F4 ~ LA v4 𔃺 *LA %D M (%J V 4 D I.- Id . - MV -4 (Ii " CA V) X F

Official Guard and Reserve Manpower Strengths and Statistics, FY 1984 Summary

DTIC Science & Technology

1984-01-01

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All Prime Contract Awards by State or Country, Place and Contractor. Part 4. (San Buenaventura, California-Ventura, California)

DTIC Science & Technology

1989-01-01

40 .4M %-4- -4h Ch4 InN0NN N .- 4 .W 00-o4< -s~ ti4N 40 N -,4- -.4.4"N -f 4000000a -4N -4 -- 4N < I 1 Go4N 61 U0000 (AN *0)d 40 40- IRSN ...4NCI -4 4-4I.I -40 -4-I4 -I-I .- 4-4-4 -1-4 4.4 -NN II K M -40,4 K n $13 IN 00>->-)-* fie IV> 4 La f4>)-* PON IRSN mu(00* IGO. KEIO-4o oz2 02 0222Z

Prime Contract Awards by State or Country, Place and Contractor. Part 7 (Lake Park, Georgia - New Haven, Indiana), FY1991

DTIC Science & Technology

1991-01-01

4 N3- 4 U n t -C 1.U.00 00L00 * 0Goa oCI LAdo .C000 4 G-4 00 -4 WW4 L.4000 0L o 30 U in0(Y) U, 0 -4-4-4-4-4.4CF 0 0M - 00 0 M f 044- (Dcu4 01 UI (U0...m rfin In in tri j3li I M) 1 16-1-4 N-4 - 00 enC 0 -4- m-N N N4-4- 1 - 4- - 4- -4 --4-4 4- dI 6) I I Im~ 1 4 1I -N 0 -4 CL 4 - 4 -0 ccw r-t- 1" w 0 m...4 -4NN4N4C UN4 uD U-1 -4- 4-IN .4- 4 O -4 1 0 K 1, () 4 0 C. l u ) i N4 0 -in 000 = - =D mN 31 Pi-.- -4 ENC - 0D K 0. 1 04t Km -0 1- .1 -0Cl 1- 0 1-0

Hamilton Army Airfield Environmental Investigation/Alternatives Assessment. Final Supplemental Sampling and Analysis Plan.

DTIC Science & Technology

1992-08-01

Areas 4-1 4.1.2 POL Area 4-1 4.1.3 Aircraft Maintenance and Storage Area 4-5 4.1.4 Revetment Area 4-5 4.1.5 Former Sewage Treatment Plant 4-5 4.1.6...Building 442 4-10 4.2 Groundwater Investigations 4-10 4.2.1 POL Area 4-10 4.2.2 Aircraft Storage and Maintenance Area 4-10 4.2.3 Revetment Area 4...Locations. 4-4 4.2 POL Area - Phase 2 Boring Locations 4-6 4.3 Aircraft Maintenance Area - Phase 2 Borings and Sediment Samples 4-7 4.4 Revetment

Equivalence Measurement Studies (Sections 1 - 4)

DTIC Science & Technology

1975-04-01

W ~ 4JJJ~4 $44 D-4C C - 4 0>N 01-a.O1- m .00 0 ca r4 ~V4) 14) 0 0 i4) 00 >... > Q)- 0 4) .ir 10 4 cc0 >%4 -,4 %4 . cI r.P 0 >t (0 4) la b 0 C)CU t4 2r...complicates some channel measurement 3-38 > 0. r~ri 04 c~0 CP co 0 Cft) 444 0 C a~ Q~ 0 0 w a. -0 40Cn I~F . " - 4, I 0 -- .2 C, W 4-J P- E -4 LA -- ý4...we readily find that ýi(t) T(F,t) y(t) +n (t) (4.15) where n(t) 77(t) ® h(t) (4.16) 4-6 4.) N. 4. ( C-7 Q) C14) La -4 4J- P4~ CNN P4 4.5 W4-4 P4 N N

All Prime Contract Awards by State or Country, Place and Contractor. Part 8. (Anderson, Indiana-Westwego, Louisiana)

DTIC Science & Technology

1989-01-01

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Remedial Investigation Badger Army Ammunition Plant, Baraboo, Wisconsin. Volume 5. Appendix K.5

DTIC Science & Technology

1991-01-01

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Department of the Navy FY 1995 Budget Estimates. Justification of Estimates, Research, Development, Test and Evaluation, Navy Descriptive Summaries

DTIC Science & Technology

1994-02-01

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Geographic List of Prime Contract Awards. Oct 1992-Sep 1993. FY 1993. (Acton (Sta), Mass.-Wayne County, Missouri). Part 7

DTIC Science & Technology

1994-03-01

ED00LEI00ED00 0D 00C ( o DE O 1 c’m mmlmmm am mm~ mII MeO ds~)(4 - -4,.4-I4 .-4 ’ 4 -4 -4 4 No v0 to M (V) 110 1 0 4’) If I (i9tot i 0 (20) D(1...ooIm~0o Uom4-( el.W it I W00 II’a4- 00 W4al 000 0al0al)04fal -n U )-4 as W IfI cacao IIZN.-4 V-4 &A-4 v -4 to CO-E..4-4 " .*-E4 4 -4 -4U1r -44-v .4 -40...n E 44V4.*4 x Cn 11 cacao MI mn -4.E W CON Off 0 00050 If >- 11 01 cooG it -4 _a LLa 11 c 1 0000 1 N4cr 11 100 0 W 1 11 1 E for 10 -4- -4 -.4 -4- ý4

Division Map Exercise (DIME 4.0). Volume 2. Dime Documentation/Model

DTIC Science & Technology

1987-07-01

Table 2-2. Game initialization code. 2-21 .3B90 GOTO 3740 3900 INPUT "I-SINGLE UNIT 2-ALL UNITS 999-STOP", Ch Z7910 IF Ch =999 THEN GOTO 3720 3920 ON Ch ...0 4) 0. 4) 4) C~ W) . L 0. m.4.4 r_0 > .-4 4) 00 Aj-i m 0434o 0 4) .1 4 1-.. CC c & C: CC c -r4 fr Ch 4)0( 00 4) to4 P, u 4 P 0 0 4.&j 4) 430 .C 40...00 U)4 00 U 044 .14-4 004- -.4 c r-4 Wc C 4) C󈧰 c CO 4. c CO w. q.4 co C ix m w4 .4 0 -4 𔃾 -H4 * 4, . u) c~1- C2 C0’- mC CH m’ C O C-44 0 ) C a) 4

Electronic Principles Inventory, Keesler Technical Training Center

DTIC Science & Technology

1990-03-01

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Building the Will to Fight -- Prerequisite to Winning the AirLand Battle,

DTIC Science & Technology

1986-12-01

Shakespeare Henry V ~d. J4 44.4. V 4. 44 4.~44. -44 4. 4.4 .44 4.44.’C.? 444 󈧰 -’ 44 4.’! .4. ~44* *44 4% 44. 4..’ 4.p4,441 44 .4 4~ .4. * . 4~4 44* 4...proud of himself, of his companions in uniform, and of those who had fought and Won the battle honors that graced his regiment’s colours or drums

General/Flag Officer Worldwide Roster

DTIC Science & Technology

1990-09-01

1 in 1 .mm ~o to00 c~J *L: to’ LLI0C Lu coz .- 01 No .jk - 1 , Id 0 - r-I...V)4) w4rI ) H -rl4 V) cd0 A)U 43) CH 0 0 1 $ 0 W 0 0) *’ 00 .4a 4) UP >, ’o 0 q U) r. ( 1 P 4’ 4)+ PC 4’ ,0~ P~ C󈧐)0O 41 4) P 4- -r4 W 4- P, 03 P4...8217) 0 vi 4l 0 rO 4-4’ ~ ) . 0 9 4)> d 04- 0.k 4 0, 0 L r4- -P +H (’I P 4. 4- 4U)W aQ ) 4C) Hd4 0 N N N ) P 4 4 I D 4-’ H 4 ( 1 a) 0 W) 0Y) L %

Isoguanine quartets formed by d(T4isoG4T4): tetraplex identification and stability.

PubMed Central

Seela, F; Wei, C; Melenewski, A

1996-01-01

The self-aggregation of the oligonucleotide d(T4isoG4T4) (1) is investigated. Based on ion exchange HPLC experiments and CD spectroscopy, a tetrameric structure is identified. This structure was formed in the presence of sodium ions and shows almost the same chromatographic mobility on ion exchange HPLC as d(T4G4T4) (2). The ratio of aggregate versus monomer is temperature dependent and the tetraplex of [d(T4isoG4T4)]4 is more stable than that of [d(T4G4T4)]4. A mixture of d(T4isoG4T4) and d(T4G4T4) forms mixed tetraplexes containing strands of d(T4isoG4T4) and d(T4G4T4). PMID:9016664

Prime Contract Awards Alphabetically by Contractor, by State or Country, and Place. Part 4. (Campbell and Parts Engineers-Comstron Corporation)

DTIC Science & Technology

1989-01-01

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Department of the Navy Justification of Estimates for Fiscal Year 1988/1989 Submitted to Congress. Operation & Maintenance, Marine Corps.

DTIC Science & Technology

1987-01-01

N $0 4 >U4. .v i 104 00 0 00 w 4) 0 :3 N r.’U -r4 0 0400 9~~ 0 (a~ ~!k= 4- w A = :3 ki td 0 l i C4In 0 m 0-4 0 NQ m m Qo o mL q~ rr-4m Q v N . 4... 4bd IV 4 a 0 k 6- u* ’ 44 0% 4 h hi Ř 0 -4 Ř 0 V’ wi *4 6 600. J a 0 $4 41 4 Q P4 6k Ca at%~ 640 4 hi � ki -4 4 $i F’ 6 4 .0 41-4 M, 0 % 4 +i c...34444 V) 9; H 𔃺 4.) W r1) 0 go 02 V4 02 *4 4)0 0 g 𔃺 𔃺 -’-4 H 0 0 - > 41 0~ 4) 0d 0 0 0 $4 (A0 .02 td 0 r * r q la0 . 10 rd 4H 04 4 .) v . 4. u.’ 50

FY 1998/1999 Defense Budget Review Descriptive Summaries

DTIC Science & Technology

1996-09-01

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All Prime Contract Awards by State or Country, Place, and Contractor, FY 85. Part 4 (Sandia, California - Yuba City, California).

DTIC Science & Technology

1985-01-01

4 40 v-4 N 0 -4 0 0 0 .4 coo coo N 0NNN N 0O.4 4 07 4 4 ’ ൷ 0 04 44 4 4 40-441* C4 4 .4 07-4 . 4-4 .4N 4 440 U00 0 0 0) 40) C. * IP InI w n WEQ...4 l NN N - 4C -N N -.4 N 10-4oIN N 14 (0 If ( 0 IL) IP 0 o- to) (0 (0 IO L) LI 1N .4 (0 -4 -4 -4 (0- (0 (0 -. 4 -4 4 V . (0 0l 40 CV) -It P.M 04 I -N...so 40 000Co0o0a* wo 46 4M6 0VV w* V * w 4. 600006-4 O00C,0Co0oCNCDO009-0 009 0i 009.-- 00000000009I, r- - , - 0p IP . 6j 0 04u ~ w w w w w o o m -- 0 0

Prime Contract Awards Alphabetically by Contractor, by State or Country, and Place, FY 88. Part 7. (Eastport International-Flint Electric Membership Corp.)

DTIC Science & Technology

1988-01-01

0 00--400000000000000-40000000000 0 q’mwavI m 00 00000(00000000000000000(0O ANIWOV I (00400550 1 0 0 5 0 t~sWOqU I NNNM C𔃻".)O)a s...4 N J 5 ’ 5 M - -4 1100-4 1 040N ,-4 N4 N 44444444-l444444444---------- -4 1 0 -40 1 <  <<ɜ< 4c 190-40 1 -4 -4- -44-4 -4 -4 -4 es!-4 -4-4 -4...009’.. I NNIN-4 NS N (7N4-4 NNN.- Cl- INN-4 "-4-4 -4 .J4 " NN NNNNNN4NC 0 N 󈧄o( 0 I >->->-"- . 5 .’ . . ....... D.

All Prime Contract Awards by State or Country, Place and Contractor. Part 6. (Alachua, Florida-Winder, Georgia)

DTIC Science & Technology

1989-01-01

0-4 N :: fIilNN N N N NNN N N N- N N N NQ’ C.-1-4 48 2 2 2 2 z z2 22 M 2 2 2 Zof 0-40 It 104 0 44 4 0 N 4L 0) M 8 It 000 filico!I 00 !d x zaW < K 011...1)2-4 -4 < tuN V)M-4 fl.11) ..- 42 1, (0N MM tcOC’)U)00-4mU)2-0 0) 00 0) i1 inC-U)N0) .4 It I N <Cj ifm-4U)’Lnw)(04) ON -44 4t00 0-4-4 -4-4 - 0 0...8217N N 4U-4.-4-4 tUN (UO) M 4-4.--4I-4-4 -4 dUO 0101 UN0I 0-4N00 11.0 0 -4 00000 --4 0 -hC A 0 _4(. 4 (A 000/00(000000() u ( , -0 ., r-at I M -4 4 C f

Cultural Resources Literature Search and Records Review - Upper Mississippi River Basin. Volume 7. Pool 6.

DTIC Science & Technology

1983-01-01

H 0- -1 . 0 - d U. 0- 4 X, i * ’w 7 E-4 rj U) r- c0 0 -4 P 4 H4 E-4 E 0- 4%D.10 0 -4 $4 )t% U4 ) H- to) 440 Ur- H- N -4-1 4--)4J 4 4-) U)iU $4 -.4 C...34I W,4. * 4-i W ) U z u L. U U En $-4 $4 -4 X M Z a)~ U4. ) 0 )c~ (a aUD ) La 0 -r - go)> 4l) Cl V U) M l W ’- V U) H-U) -4 35Cl ( P ’.44 0 $- Q ~- -H U...gr I E U C0 0C) t41-H. H- V U) 4.) En 0--4 10uVr LA I H- r- C3 U -4$k V C4J W :: - c Q)~ r. CN C3 r i-, 11 H - N n 04 004 4J E- 4 M 0 04 -4 UU) 94 0 p

Installation Restoration Program. Phase II, Stage 1. Problem Confirmation Study, Luke Air Force Base, Glendale, Arizona.

DTIC Science & Technology

1984-11-01

CONTENTS Section Title Page 4.3 Water Chemistry Conditions 4-10 4.3.1 Groundwater Quality Results 4-10 0 4.4 Water Quality - General 4-11 4.4.1 Water...Quality - General 4-11 4.4.2 Water Quality at LAFB 4-11 4.4.3 Soil Quality - General 4-15 0 4.4.4 Soil Quality at LAFB 4-15 4.4.5 Conclusions 4-16 5...ALTERNATIVE MEASURES 5-1 5.1 General 5-1 0 5.1.1 Base Production Wells 5-2 5.1.2 Current and North Fire Depart- 5-2 ment Training Areas 5.2 Summary 5

Climatic Conditions at Air Force Bases in Australia,

DTIC Science & Technology

1980-10-01

U"- C 0 - 0 4 4.M57 c 04. %OOOli~ 0C On mm 14 - 4P , cC)r )Go - 4-) 0 to to r. C)C r44 C V 0 ca.. x . . 04 1 -4 r-G 0o .4 4= 1. -40 -4 ) 4 04 Ju~0 C: 04...8217 0 C) 4.-4S- 0) to 0) N 9 0 4-4 4 4 1-4 -4 .- 4 4 -4 4 0 .4 W ) $4 .f in0A . T - :T -’ s- 4P .-4 C.) cn c 4 C- - 00 m 0 F-44 m)0J- ~ )N U) " ) enp co o...cyclones causes problems in predictfng extreme gust speeds for coastal stations north of latitude 30*S as was discussed under Extreme Rainfall. As was

All Prime Contract Awards by State or Country, Place, and Contractor, FY 87. Part 16. Aberdeen, North Carolina-Youngstown Municipal, Ohio.

DTIC Science & Technology

1987-01-01

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All Prime Contract Awards by State or Country, Place, and Contractor, FY 87. Part 9. Abilene, Kansas-Yarmouth, Maine.

DTIC Science & Technology

1987-01-01

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All Prime Contract Awards by State or Country, Place, and Contractor, Fiscal Year 1985. Part 9 (Aberdeen, Maryland - Woodbine, Maryland).

DTIC Science & Technology

1985-01-01

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All Prime Contract Awards by State or Country, Place, and Contractor. Part 8 (La Grange Illinois-Wichita, Kansas)

DTIC Science & Technology

1990-01-01

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Manning Implications of Logistics Support for Airland Battle.

DTIC Science & Technology

1985-10-01

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All Prime Contract Awards by State or Country, Place, and Contractor, Fiscal Year 1985. Part 20 (Antilles - Israel).

DTIC Science & Technology

1985-01-01

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All Prime Contract Awards by State or Country, Place, and Contractor, FY 85. Part 15 (Altus, Oklahoma - Zelienople, Pennsylvania).

DTIC Science & Technology

1985-01-01

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Prime Contract Awards Alphabetically by Contractor, by State or Country, and Place. Part 13. (Michigan Power Company-Noord Natie S V)

DTIC Science & Technology

1989-01-01

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Civilian Manpower Statistics, December 31, 1992.

DTIC Science & Technology

1992-12-31

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Prime Contract Awards Alphabetically by Contractor, State or Country, and Place. Part 16 (South Dakota [State of], Brookings, South Dakota - Tekna, Mountain View, California), FY1991

DTIC Science & Technology

1991-01-01

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Prime Contract Awards Alphabetically by Contractor, by State or Country, and Place. Part 8. (General Contractor, Inc.-H and H Industrial Instruments)

DTIC Science & Technology

1989-01-01

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Allatoona Lake Destratification Equipment Test Appendix C: Operational and Water Quality Data 1970

DTIC Science & Technology

1971-02-01

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Dollar Summary of Federal Supply Classification and Service Category by Company. Part 4. (R414-V129)

DTIC Science & Technology

1989-01-01

m L -. LA. -4 - A. - Z> A.-4 t. 0) L1 -4W (a U) (a 0) td ) 4a 4 a) Q’) -4 c _4 ." < 4M U- Ic C40 -i D Zz >J 0- Z > > 0 2U~2 2 00 04 " 4 0-4 z 0 0 O 4...m. to4 . -4 0. - 4 -4 -a -4 - td c4 .. M -4 M. () I-~C 0I0.-I LU~~~ I-- QID 2 2c w 4 2 4 2 22 2 0 0 4’ I I- I z LI- - , o < 0 w, uu 0 E Z I w 0 -. 0...00 o 0 -4 LI I0 0 0 0 0 0 0 0 0 - Z) D0- - 0~- -44 4. _-4’ Vn L- 4 4 ’ 2 ~ 4-l I0 0 0 0 0 0 0 0 A. td - 0 L A . A W0 -WZ -. w r CA (A - -4 L) . 0 0 0

All Prime Contract Awards by State or Country, Place, and Contractor. Part 11 (Methuen, Mass-Winsted, Minnesota)

DTIC Science & Technology

1990-01-01

4 N GAo (0 C2N 11 .12a- 0. ir El 02- 110L 0 Ix .m I M -4 If CU U.w 1 M-4 it 0. .NNj00 00 00 000 ( 0e(ON0r-C400 Dc4c0c)c nr - 4 o-4 - 4 ( or- 41.n0...N N N NNIN NNNN""J.. .. "N6-Jt.. .. . .. .. 6% JINI oN IftG 4 0*’,fL N 44 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 444C 4 N -4j ca)0 0 IMZZ Z Z Z Z Z Z ZZ Z Z...M In c’) w o-4 um am aW-a4 a Gao Winul)U)U)) 00 1,17im)ala) L" 0 00 Q a (1) U ) n) U 0 ma 0-4 amcC) C(NNNN.N.NNNNNNN c3 ca-.- C)- CNN cQ w coo maaM

An Interactive Computer Program for the Preliminary Design and Analysis of Marine Reduction Gears.

DTIC Science & Technology

1982-03-01

4 E-4 c 043 04 4 E- PQ = 24 0 0 E- m 2054 4a =44 Env)2 d0 a b43 09 0 4 I6.4 44 = w. 0k2. . U)3c m 00 I= =C * 4 0 . O)U ad i 0 0~P In3 U= 4 40:M = 4 m...pa *Q4 2 c4~ .~ co N ra a9.* o H 00a = = :b4 H~ H U (3 C) U- of *4= t. E- H)40 UUO *n04 043 q N. W E-4 E-4 1.4-0 31 H 000 oi-4. H4 - M0 2I 2 04 E- HU...aO o %-c ’. %D in0 o f 3W -+V E4pa a noM pa pa pCa 0 pa H14 . pa H 1.4 pa ~00 MtH x 4 -4 U 4E4E4 0 E-4 H E ~ CaM N4 -40 0 UE- E.UE- u 0 c E4 0 9 E-4

All Prime Contract Awards by State or Country, Place, and Contractor, FY 88. Part 10. (Acton, Massachusetts-Zeeland, Michigan).

DTIC Science & Technology

1988-01-01

4 4) . 4U o < 0 -C- En 0 -. 4 _U 0 C) 4) v) 0 EU-7 C V~-4 -4 En4 ) U 0 r o A-4 0 0 0 z -4 = , = 0 0 CDQ v " C, V EU m V) 41 h- v 0o 0 r o~r .i . E...0 -0 41 A- C w- . 4) 0~ 04 0 .4 0 - 4 L) - 4 o0 m 4-- 0 U n U 4 (/) 0 - En to > . EU 4 4 4) :3 O = >, 41 r= O = EI 0 m - A-. 4) C En z 4 . ) w4) c V...V ) - j Ch ) EU fo u L) 0. o0) oo <n 0 -) 4nV E 𔃾 U) 0 . - - ) 0 - -- co 4.- c C0 0 -4 " > q in CO - 00 0 ... C4 0N m . 4) - .- 40 0 En 0 C n EU

Job Importance as a Moderator of the Relationship between Job Satisfaction and Life Satisfaction.

DTIC Science & Technology

1985-11-01

5 - .. . . 20 -- :7 - e *x M 0 r - -4 ~-4 I -4 .- 4 1.4 0 00 ~ ~ ~ 4 MCJ’~4 O( ZK I K- c 4C-K 4 00 -4 0 -~ I O 4 * a . I0 3 .0 K K -.4 03 >U M ?-4O...A. D. Biderman & T. F. Drury (Eds.), Measuring work quality for social reporting. New York: Wiley. Bamundo, P. J., & Kopelman, R . E . (1980). The...44 04 0 ( C C14 -A4 4.’ 4) 0. 0 0 ’.(,l2 0 *~~~ C 03i4*. ~ . I0 4.4 0H 10 It 00 CO 0 .4. q C4 0 U) 1C4- 03 4- 0 - . 0. w. . r 1 0. K 1 0 sz (U 00 1,-4

Electronic Principles Inventory, Lowry Technical Training Center

DTIC Science & Technology

1990-03-01

a44.4 , .4 . 4 0 100 0DW IC C 04 ~0 I L4 6 C .4 I 6 l # a’ I M 4 f4 .4.*4-4-4 .4 .z 4’Ř 1. 0~ L3 - CC4𔃺"Z 46.L f6 14 D D 4C 24 :4 244 Ř’ .4 𔃾 64 z4 1...0 00 a 𔃾 1a 40 4 aH r0 a a4 04 - .0 a 4 44 ao a c 0 C I. a, aD a c 4’ a 1 a0 m .0c .0~ a Co5 0 a,’ 0 aa . 0 a 0 a4’ a -C 0C I’ a 0 aCCa Ŕ,’ - C NO a4

Geographic List of Prime Contract Awards. Oct 1992-Sep 1993. FY 1993. (Air Force Academy, Colorado-Washington, DC). Part 3

DTIC Science & Technology

1994-03-01

0 0 a a. aL OC I ccN( N NjN W4~)4l~4v)4 (4(Vf) qq nn %V) 4(4f) V) t4)m (W aN in(0cl N r bPP % Pr. .r% 4ý a. PI% N.r.r Pr%I. P.. r... ar..a r, .. P a...J4 It) 0 Ut00 .1 IfI WOW04 160.4 .4 -4.4 .4 .4C4n -4.-4.4 (n -4 N-4 N P, Ln W Lfl40q 4OD Y 0) -0. 0 M Cn6 6 100400 11. O ffa I W6 co0 o it >- iI U I

Alpha List of Prime Contract Awards. Oct 92-Sep 93. FY93. (Leventhal Bros & Co. Inc. - Martinez A M Construction)

DTIC Science & Technology

1994-03-01

cacau u uIn t c o 3I ac a uu ~In uuuu t aac nu nuCLn wmu u nu wu uu u mm wu II I CO -4eNI 01 - -4---4 -- 4-4-4 4-4 - 4 44------4-4 w4-4-4-4----q-4 ý...4NOH 00 0 0 0 0 0 00 0 0 000 0 If Cg) -4NmlI aWit 11 C -04N( goH .-4-4 ON 01 a) a) a) 010 07111 cc -4 N a H (n1 n U 4 u cc Go :1 (A CACAU (11 (0.- CiN 41

A Training Feedback System for Brigade Command Groups

DTIC Science & Technology

1978-06-01

n >U ~4) 4-- NL 4-o 0 L H vc 0 ( a wE -a 00CO 4 i0 a) cab 0 O0N 41-1-N r-4 N 4- 0o 24AN 1.N *r4-4 4-1 4-IN -’H COr i H -~ d - H- 1()e4J El4 r--4 w U...4 P $ ~4 ) El4 ) Q) 1) In 4) *Cd a. "C "oH I H el ( c. 0 -H4 Xr C 1OO0 𔃺 4-J co ro41-’H 0- 13 . 0Cd 41>ý4J r--H Ca Co r 4.4 HCdCJ 0 >" a) C-. 0 0000

Synthesis of Microstructures and the Relationship between Microstructure and Properties.

DTIC Science & Technology

1980-03-01

4 ((A .00 04 0. - 4 0 ~ ~ W0 ~ 4 VI 4 .- -. 4 ’ 4 1.. 1.4 4 0 w A4 6 -0 U ’ a4 0. 0. 430 (40 0. . ( 4 ow( 4 4 -1 0 4 4.44 >0 . 4 , 00 V 1 a.44 a0 ’a (0... 4 (vw (0 to P4 41 0 U) a ( 4 cc I v v cc1 0430 a v 1.. W w SECTION III HYDROVAC Earlier research at AFWAL/ML with titanium wrought alloys [66] and...Quart- erly 16 (1976), 33. 4 . D. Eylon, "Crack

Stress History Simulation. Volume 2. A User’s Manual for a Computer Program to Modify Stress History Simulations

DTIC Science & Technology

1977-03-01

4444444.000000I00071 7 Z 7 7 > > > > 𔄁 > > 27 Z 2 *.JUJUJ30T. 4444.4 .4.4 .4 .4 . . . . .4 . . Utiulti iLK) LMUJL) it)LJit)Li it)Lit)LULNJt)Lit .31)0 MiLK ...M4-cUro r4-4-t m4~qoIN 0--r..44-m.O40iinn’O4-in.0C’JNO.4tDMCU~r-- (uor-r-04-* V44 1 \\J.-4’ 1 C’) -PM.-4. .- 4 11-4 W4 I4 .4-* fl44C .tl. I4 MUCU 3 I

Descriptive Summaries of the Research Development Test & Evaluation Army Appropriation FY 1982. Supporting Data FY 1982, Budget Estimate Submitted to Congress January 1981 (Amended 30 March 1981) Volume I.

DTIC Science & Technology

1981-03-30

J O 4 ) ) ... , .4 A -I 4 a 0, 4). 0 0 0 C0 4 .%d L 4 a a 0 .4d A C .4 . u41 104 416 0. 4 4 4 .u4 4 ag to %I a4 M1 u a d- 0 &a a~4 M. a * 1 cc11 04 a... ag U 44 a C6 A a P-41 4.1 4 4.4 4 a.1 A 1. CO ŘO 04 01 0% 4 14 A Z440 41 a M UA0 P0. a1 A 0 00 M 1 4 L. 41 0 41.4 . a. 1.4Mu in. ola 0- u0 .0 x40140...414 5 S 40 a ag ~ z .3 m4..~~- 00 a5 00 3 k MS U4 r5 -4 CL A. Q- Aj an I a 0o44 o-da’. .0 0 d .u S. a44. %00 w~O SO u4. -4 a0 UW v5 .4 . ! SM~& .44 P-0

Prime Contract Awards Alphabetically by Contractor, State or Country, and Place. Part 9 (Hewlett Packard Company, Foster City, California - International Bus MCHS Corp, Louisville, Kentucky), FY1991

DTIC Science & Technology

1991-01-01

44 0 4 N in M 4 a amN LU-4 OJ4 00o O-4NNN00 04-7)07 0m ()0) 1-0 U0o -4 mwNO r NO N x QO 000 LU00000W( MOO5 XU0 £000 a. ] - -4 F6 .. .5n -.J4 J.4 mm4...4 NNa0 1-am ~a") Ia 4-. -4 - 4 -*** o Q o o ooQ00o00o--44- 01 D .C 1C w : am 1 C00-4 1 l I co -4 mmiN4f4N- .N 4-4- .4 III aCca 4 aa in 0 n 0 0 0 00...04NNMOCOMO -4-4 -.1 640 IIOf-N4.-0444000.40-..400 <mNOO4-40000000000>C C-4- < Ia 4 0 <C’) Is ZZIW a.LL~a.La. 0.A 60 < 4Ni to I IfO(-0(N40ml0ilOONt’. f6 -4 6

Prime Contract Awards Alphabetically by Contractor, State or Country, and Place. Part 11 (Lemmon Company, Sellersville Pennsylvania - McEwen Construction, Beale AFB, California), FY1991

DTIC Science & Technology

1991-01-01

Mw N1 -.44 N 0000 0a a I IS -40 UA 00000000000- P- 1 0 WOO 0 -404 0N 0 U-4: 5 -4to U 0 C4N N N 0044044 .4 w4.4 .4 ..4-4 -4 ~ (’ C m C. U-4 W U-4N U1...ininO4Nsio 0 in0 0) ON4CS in 0000 4V In ( wo U 0 -44! in W 14 01V- -4-4.4 N00r -4 .4 -4.50 U 4 0OO 0 -4-4 NM in N4 U> O- :i00 U 1 %. 1 woo00 U .4 U...40O0 in wU1444 30 0o I0 U46- 1I cd 0 U )4444444 C in 000 0 L- 1 - 4o in 0000 er- int N 0I1 COCO U .A140NNNNNN min 000C -of- ’C00 0-4 m.C1-r1 win 04

Prime Contract Awards Alphabetically by Contractor, by State or Country, and Place, Fiscal Year 1987. Part 7. Fairlane Gear, Incorporated-General Fiberglass Fabricators.

DTIC Science & Technology

1987-01-01

I N V4 (9 4 I D (9 ) -I m -I ) N0 -4 % r. 0 P.- 0 N D N N4 N N - n Y 04c l 4DJ N 0 N M N Nr AN40N "NN " eNC , % 1 (0 -I N N -I 0- I-4- N .I N N 4 4...EUW U w I uo u Z z x 04 0 Moto0 -4 I -4 -4 -4 N-EN -4 -t 4 --4 C. 𔃾 -4 -4-4 - ENC W- @0 m mm041I 0’ Cl) M’ C.) m’C)’ M170’ M’ @00o 0. on -4N cl N4N N1...X jNN, -INN -4 w. &M w 0 0 0 Ot -4 I ) .40 44. 44 .- 4 - ~ 4 4 -4 NNN a~ .4 W1 * CI000 I 0(000-4m 0n 00 00 - 0 0-I -- 0 0l 000.) 00-J 00..J)C) enC

Prime Contract Awards Alphabetically by Contractor, by State or Country, and Place, FY 88. Part 10. (Hitachi Instruments, Inc.-International Cordage, Inc.)

DTIC Science & Technology

1988-01-01

4 4 4- . 44" loo 1 n 1NN Nl Nl " 4 0 r- r- r-r- r 1% - r.r- lr-..-r Pr l ’)0014 I 0 󈧄V 1 0 󈧄V 100 (10 I " jci "ci C,1 l 1 1 74cI 0 N NNN N 0 N 0e...0N N* 4C N SN C4 C1 SN 1000 1I-C4N N N NNNN C4c jci ,qr N NN ON 0.N(4N U) N UCN ZN I-4N C ZN 1’o00000𔃾) 000000000-)00000000 0 030 0 Q 0 0 0 100 ...1n0.4 - l00om 4 4- 44 4- 4- -4 4 -4 - -4 -4 .- 4-4-1 .-- 4 4 -4 ) -4 lOONi nI I nI I nI i nI I f u,v)lUI u 11) -4 100 -4 m (1 c’) mm ) mMIM ) mM) M c

Dollar Summary of Federal Supply Classification and Service Category by Company. Part 1 (AA11-AZ16)

DTIC Science & Technology

1990-01-01

4 -4 4 I ~ z I % - . - 4 : -4 )1 4 : 41 -I I I I Z NI 0m m - 4 a _4 it m 4 cc -D 0 m m 4- _4 LU LU 0 24 tm x. 0. IL4 ..4 x. ’x x. . ILC C-) 0) 414- C1...Ql I CKI < 2 0 (4) I cm m 0 c. w 00wcom 0 --4 r- co w l c, W 0000 0000 ( tm ’ N -o "- -4 o’ V.L t v w L - w - o -40( cl m LA m44 -4 Cl) 1, en -4 L...l ) C 4 ) 0 ) ) tdC ) 0 t a C) a) C ) cl 0 I C)1 I I I I I = - -4 I I I n -4 Im -0 LU w 4L 4 4 - 4o 0 01 I 4 L. I oA CO 0 41 1 0 IV C) (13 ml Cl IV

Perspectives on Reserve Attrition

DTIC Science & Technology

1988-10-01

potential differ- ences between Junior Enlisted, NCOs, and Junior Officers. How- ever, these data are likely to be most valuable when viewed as one...w I C4 1. I4 -4 1 44 1 E-1 I- E-44I - -44 g z-. 4-) P E 4) I - - W r.- Ix~ o I >4E-4~ 0 a4OE-4 ~ I4 4 >4E-4 1 ladO I 0 IM -4I ~E- H E4~ r. 9 E-4O W4 I

75 FR 27956 - Airworthiness Directives; Airbus Model A300 B4-600, B4-600R, and F4-600R Series Airplanes, and...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-05-19

... B4-600, B4-600R, and F4-600R Series Airplanes, and Model C4-605R Variant F Airplanes (Collectively...-203, and B4-203 airplanes; Model A300 B4-601, B4- 603, B4-620, B4-622, B4-605R, B4-622R, F4-605R, F4...

Investigation of the Effect of Low Level Maritime Haze on DMSP VHR and LF Imagery.

DTIC Science & Technology

1980-09-09

LA S LO i-4 CNJ 0) r m~X LA3 crj (N > Co -i s- - -I CN r -~ 4J. 4-4 C) 4-) >1 Cl) 0H 9 -r-( Nl NV C 0 MN (1)0 r4 s-4 L 4-)4 Uv) Cu...be approximated as : 5-12 o 0 LA r40 oD (n rn N .4 .-4 0 C14.. LA Ln LA N- 0N 0C) LA 4 . l4-) r-. LA en C4 N . 049 0 1 E-4~ . (1 0 .t 0 ’p .r LA LA LA ...w CN C1 04 .00 C4.) r -4 O N~ ’. r - CA a ’.0 LA w m~ N1 Q4-1 Ř .4.4 Q) I- Q) in - r-4 O 4 1d𔃺 -4 0 0 4J *-0 0~

US Army, Air Force, and Navy RPMA Consolidation in Panama. A Cost- Benefit Analysis. Volume I

DTIC Science & Technology

1979-09-01

4 M4 4 -~ hi 𔃺~~, 8 wu * ’ * Na A4V41 0d 00* ~~41C4 C6 - .- 1 ~fl .(’ 4 r4 - EJ ~ :f4 400 re V- 4 Id a 3960 b(3) The fourth column... 4 . 4 0- 4 :64 0 4 V4 %- V4 u -F.e*,* V4 g~I c c 0 a. c O 41~ V 04 S 8 J *h.0 >. 44U . U QS U) 4 U 1 ~- 4 0 0 va b *v 0 -.- - 4 .- 4 Wu" A 4 IW ra...Is A 8 1 I~~~~~, 5-- 4 -Ž’ .v*C ~ * ~ ~ ~ ~ ~ ~ "o ’ I

Prime Contract Awards Alphabetically by Contractor, State or Country, and Place. Part 8 (Giordano Associates Inc, Long Branch, New Jersey - Hewlett Packard Company, Cupertino, California), FY1991

DTIC Science & Technology

1991-01-01

0F- CDin in V0 55 I (0-I U 41000* 0- F-3-r 4 - InIL. Ln f4 F-LLI-4.-4f-F- ". U 0L I M-4 U 4-I0 F- F-4 04 InU.4c 04 = O w I4n400... 4 : (0-4 U W- InIIL...1cI- I.- F- I.- 0D I- I- hi I M i-4 a 2( 20 O 20 ZOCCCOOOOOOOO 0 zOWWQDQDCOOOOOI U3 1 S i-4 55 c% WN"h4 W -4 w - 4 MCMrM)M.MCM)M’M-4 4 4 4 hi -4 hi-4-4...0 0 00 0 0 00 0 0 00 0 0 M- 55 i-4 II mm ic x x xx xx x (n NI in4 N -400 -40CD -440 -4 00 0 00 C 0 00 0 0 0 000 .4ɚ 0aC 4 D0 00 000 4N S n0-I K 000A

Official Guard and Reserve Manpower Strengths and Statistics. Fiscal Year 1982 Summary

DTIC Science & Technology

1982-01-01

DI ’a D~ U.. O 14( 11) f.IF) U0 0F)Cn D.4- F- aIaDP iDC n l 4. wlU a’ ý w fN 0 n C K) T) -P" F CW a l ) Nn w) (’o F-4 o( C...CIn OW~I ;0 - 4MT 4i on 0. H WI l - 0 PI4 .4C) .4i 4 4 N W’)NNP) t .’ P2-iP I flD N 4I LL. (F L0 Di0C )t Di YW 0 4 O %W nll)ýP ON sý4 )"C I LP ,I N 6...8217 V) 4K 1L 6; - N In 4ý v4 w4 O0a vC l 4440 4K 6K1 I DI 4’ tflLi 4M 49 ii 4. ;c 4i 0 W 4 M. wIL In 0q x~ 4i w. cc 4 4j 64 6 w0 ~ 0’Ir 0 .4’ m 4 V 4

All Prime Contract Awards by State or Country, Place and Contractor. Part 19. (Abbot, Virginia-Yorktown, Virginia)

DTIC Science & Technology

1989-01-01

C C.CV)i 17)0 4*0 1"-ooO 0 ooOO0-0oooO0 00 1-NN W on XIIOI0 0-4 of4( NOwO (004000a . w 000) -400) 0) 0) )0) 0) 0)0(4 ) )0)0 CY ( -4 00Q WC> Co- if < 1...11 04 0-4 --- C’m 0)-4 ?.-4 0)00tMo (D C𔃾 ONN -*-* 0C’)I i W11< 347 ) 61IC-N -4NNN"NN 0-4 LO -4 4 -4 00.4-4 t-- 4 -4 -4 -4 Ni-4 -4 a) 0 011-01 <m’ t 𔃽r

Crystallization pathways of sulfate-nitrate-ammonium aerosol particles.

PubMed

Schlenker, Julie C; Martin, Scot T

2005-11-10

Crystallization experiments are conducted for aerosol particles composed of aqueous mixtures of (NH(4))(2)SO(4)(aq) and NH(4)NO(3)(aq), (NH(4))(2)SO(4)(aq) and NH(4)HSO(4)(aq), and NH(4)NO(3)(aq) and NH(4)HSO(4)(aq). Depending on the aqueous composition, crystals of (NH(4))(2)SO(4)(s), (NH(4))(3)H(SO(4))(2)(s), NH(4)HSO(4)(s), NH(4)NO(3)(s), 2NH(4)NO(3) x (NH(4))(2)SO(4)(s), and 3NH(4)NO(3) x (NH(4))(2)SO(4)(s) are formed. Although particles of NH(4)NO(3)(aq) and NH(4)HSO(4)(aq) do not crystallize even at 1% relative humidity, additions of 0.05 mol fraction SO(4)(2-)(aq) or NO(3)(-)(aq) ions promote crystallization, respectively. 2NH(4)NO(3) x (NH(4))(2)SO(4)(s) and (NH(4))(3)H(SO(4))(2)(s) appear to serve as good heterogeneous nuclei for NH(4)NO(3)(s) and NH(4)HSO(4)(s), respectively. 2NH(4)NO(3) x (NH(4))(2)SO(4)(s) crystallizes over a greater range of aqueous compositions than 3NH(4)NO(3) x (NH(4))(2)SO(4)(s). An infrared aerosol spectrum is provided for each solid based upon a linear decomposition analysis of the recorded spectra. Small nonzero residuals occur in the analysis because aerosol spectra depend on particle morphology, which changes slightly across the range of compositions studied. In addition, several of the mixed compositions crystallize with residual aqueous water of up to 5% particle mass. We attribute this water content to enclosed water pockets. The results provide further insights into the nonlinear crystallization pathways of sulfate-nitrate-ammonium aerosol particles.

All Prime Contract Awards by State or Country, Place and Contractor. Part 7. (Aiea, Hawaii-Zion, Illinois)

DTIC Science & Technology

1989-01-01

000 oao 0000 ’ 0 10 1 a I 0> I 01300011N 1 in 21 14-4 4140 (D 0 0 N1 -4 U) C1) (n N W I U)rK>U 11 0-4 -44-4-4 q-4 0-4-4-4 0.4 -4-4 0.-I 44O N N N in...4 if4-00 )r )(O c 00 -4 00 NO 0M 04 ,P-4 (4M (07) (0 r- on 1,-4 144(I0M4 if4-4 ."(-10 t VI = 141 Mx 00 Ni 20 4441 00 M 1 V 00 N 00 < 4140 ) I(0-4l if 4...00 4 44 It -0440 M 0 100 0 100 I0 (10 000000 140000 4140 MOO w- SI - x M fit0 mI M0 -40 1-400 -4 I -0 .n Z-400 0 0 -40 󈧬 045 I4’ (04 II .-4N 0 c

Prime Contract Awards Alphabetically by Contractor, by State or Country, and Place, FY 88. Part 11. (International Corporation-La Ronda)

DTIC Science & Technology

1988-01-01

0 0 cau ( 5 . 4A 0 . d) - W 0 4Ao 0 C00 C -4 43 CL ..4 430 o m 0 ... 0 - CL- W 4 3 U 0 0c- 0 CI 0 -4 m. 43. 03 4 5 . 0 00 ’. C 43 S -4 Sn aW ’- 4 0 4 . 0 < _4 0 4w E E -4 - 06 M4 mW cc 5 . 0 4W .o . 0 2~. ~ c .= 0 >1 0 E3 2... 0 0 003 N, *- to C) 0 N4 U 4 -% -m U 0 -4 .-.4 3 C 4 -40 0

75 FR 60611 - Airworthiness Directives; Airbus Model A300 B4-600, B4-600R, and F4-600R Series Airplanes, and...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-10-01

... Airworthiness Directives; Airbus Model A300 B4-600, B4-600R, and F4-600R Series Airplanes, and Model A300 C4...; Model A300 B4-601, B4- 603, B4-620, B4-622, B4-605R, B4-622R, F4-605R, F4-622R, and C4-605R Variant F...-- Dated-- A300 series airplanes......... A300-32A0447..... April 22, 2004. A300 B4-600, B4-600R, and F4...

Bridging cobalt-calixarene subunits into a Co8 entity or a chain with 4,4‧-bipyridyl

NASA Astrophysics Data System (ADS)

Liu, Wei; Liu, Mei; Du, Shangchao; Li, Yafeng; Liao, Wuping

2014-02-01

Two novel calixarene-based compounds, {[Co4Cl(TC4A)(HCOO)3]2(4,4‧-bpy)2} (CIAC-206) and {[Co3(H2O)(SC4A-SO2)(HCOO)2]2(4,4‧-bpy)}n (CIAC-207) (H4TC4A = p-tert-butylthiacalix[4]arene, SC4A-SO2 = p-tert-butylsulfonylcalix[4]arene, 4,4‧-bpy = 4,4‧-bipyridyl) were synthesized under solvothermal conditions, and characterized by single crystal X-ray diffraction analysis, TG-DSC analysis, elemental analysis and IR spectroscopy. These two structures are featured with isolated Z-shaped Co8 entities containing two Co4-TC4A subunits bridged by two parallel 4,4‧-bpy (CIAC-206) and some zigzag chains with [Co3-SC4A-SO2]2 dimers bridged by single 4,4‧-bpy (CIAC-207), respectively. In order to evaluate their properties, the N2 sorption behavior and magnetic property were examined.

Casualty Estimates for Contingencies. Volume 2. Appendices.

DTIC Science & Technology

1985-11-15

r .( E 4) C 0C0C O.C L - 0 1-L-0 3.14 >0 0C) m>1,-. c4 00(00 4 co 0 uk Cr C0 m a0 0c 4)5V) NU) 4)) 3UV ) 0 4 LL . .- C4),u %0) c :3 W 0) 1O00ZC 4) C 0...4) .) .) L -L4a) -4 c r - C(C0.Z.-4 -) 6EE>i-L> o V) L. VLLUS- )-4 ) 4) LCUL. 4o) - -4 r- 0C M C.-4 0 0 M aL. w 4) - r- V CO 4)0*- tD V) N X, V) U M0...34 , . . -- ," - " % t- a, -~ U 4-) 1 . 1 _0 S- %V - a) (V % S-~ ~ -4_ _ _ _ _ 1..I l c 0 S 0~L -0 CU4 E~a 4- c0 CD" 0 .- 4 - ra.- 3 oo -4 tD 41 ( A V

Polar Cap Plasma Convection Measurements and their Relevance to the Real-Time Modeling of the High Latitude Ionosphere

DTIC Science & Technology

1987-05-07

C -- 0- Vz 0 t O L- mU d-) 4J) 0 CJ 4 o *U )Cw O.C NuLt 4 fJ EVl. 4J o 0*-.C.C (U C4) C Lj q-.4 C :0C -’V0 +J 4-) 4J = to ’ C aC > L- 41 >% L. * 0 0IVL...to LeU (A IVc u~u ~ e C Ŕ 4Jt U 1:W ML-4C4- Q) 41 E C ) 1 0 a) 0 4 d) .Du’ n A - o )( 0+.) c 0 a 4--l 4.) CD 0 Vo I C )1 = r L.. 4L )- -~4-.) C U 0)-4...r- C : 4-) 4-) -)- M 4-J = 0- C ) m er- 4 n CA (0 4 a) m 0 aC) a (u- 4-0 *+r- P. to -

A Versatile Low Temperature Synthetic Route to Zintl Phase Precursors: Na4Si4, Na4Ge4 and K4Ge4 as Examples

PubMed Central

Ma, Xuchu; Xu, Fen; Atkins, Tonya; Goforth, Andrea M.; Neiner, Doinita; Navrotsky, Alexandra; Kauzlarich, Susan M.

2010-01-01

Na4Si4 and Na4Ge4 are ideal chemical precursors for inorganic clathrate structures, clusters, and nanocrystals. The monoclinic Zintl phases, Na4Si4 and Na4Ge4, contain isolated homo-tetrahedranide [Si4]4− and [Ge4]4− clusters surrounded by alkali metal cations. In this study, a simple scalable route has been applied to prepare Zintl phases of composition Na4Si4 and Na4Ge4 using the reaction between NaH and Si or Ge at low temperature (420 °C for Na4Si4 and 270 °C for Na4Ge4). The method was also applied to K4Ge4, using KH and Ge as raw materials, to show the versatility of this approach. The influence of specific reaction conditions on the purity of these Zintl phases has been studied by controlling five factors: the method of reagent mixing (manual or ball milled), the stoichiometry between raw materials, the reaction temperature, the heating time and the gas flow rate. Moderate ball-milling and excess NaH or KH facilitate the formation of pure Na4Si4, Na4Ge4 or K4Ge4 at 420 °C (Na4Si4) or 270 °C (both M4Ge4 compounds, M = Na, K). TG/DSC analysis of the reaction of NaH and Ge indicates that ball milling reduces the temperature for reaction and confirms the formation temperature. This method provides large quantities of high quality Na4Si4 and Na4Ge4 without the need for specialized laboratory equipment, such as Schlenk lines, niobium/tantalum containers, or an arc welder, thereby expanding the accessibility and chemical utility of these phases by making them more convenient to prepare. This new synthetic method may also be extended to lithium-containing Zintl phases (LiH is commercially available) as well as to alkali metal-tetrel Zintl compounds of other compositions, e.g. K4Ge9. PMID:19921060

Boundary Layer Dust Occurrence. 4. Atmospheric Dust over Selected Geographical Areas

DTIC Science & Technology

1977-06-01

and Country Table (s) Barranquilla/Soledad, Colombia 4 Batticaloa, Sri Lanka 4 : Belize, Belize 4 Berl i n/Tempel hof, East Germany 4 Bilma, Niger 1...32 Birlad, Rumania 4 Birni J’Koni, NJiger I1, 33 Blavand, Denmark 4 Bogota/El Dorado, Colombia 4 Bolzano, Italy 4 Bonifati, Italy 4 Botosani, Rumania 4...Frankfurt/Ming, West Germany 4 Friedrichshafen, West Germany 4 Galati, Rumania 4 Gao, Mali 1, 8 Geneva/Cointrin, Switzerland 4 Girardot, Colombia 4 Gorlitz

All gene-sized DNA molecules in four species of hypotrichs have the same terminal sequence and an unusual 3' terminus.

PubMed Central

Klobutcher, L A; Swanton, M T; Donini, P; Prescott, D M

1981-01-01

In hypotrichous ciliates, all of the macronuclear DNA is in the form of low molecular weight molecules with an average size of approximately 2200 base pairs. Total macronuclear DNA from four hypotrichs has been shown to have inverted terminal repeats by direct sequence analysis. In Oxytricha nova, Oxytricha sp., and Stylonychia pustulata, this terminal sequence may be written as 5'-C4A4C4A4C4 ... 3'-G4T4G4T4G4T4G4T4G4 ... In Euplotes aediculatus, the sequences is similar but differs in the lengths of the duplex region (28 base pairs) and of the putative 3' extension (14 base pairs). Also in Euplotes, a second common sequence of 5 base pairs (A-A-C-T-T-T-T-G-A-A) occurs internal to the terminal repeat and a 17-base-pair heterogeneous region: 5'-C4A4C4A4C4A4C4(X)17T-T-G-A-A ... 3'-G2T4G4T4G4T4G4T4G4T4G4(X)17A-A-C-T-T ... The length of the terminal repeat sequence for O. nova was confirmed in cloned macronuclear DNA molecules. Images PMID:6265931

Electronic structure and fragmentation properties of [Fe4S4(SEt)4-x(SSEt)x]2-

NASA Astrophysics Data System (ADS)

Fu, You-Jun; Laskin, Julia; Wang, Lai-Sheng

2007-06-01

A limited exposure of (n-Bu4N)2[Fe4S4(SEt)4] solutions in acetonitrile to air was found to produce a new series of [4Fe-4S] cluster complexes, [Fe4S4(SEt)4-x(SSEt)x]2- (x = 1-4), with the original -SEt ligands substituted by -SSEt di-sulfide ligands, which were formed due to partial decomposition of the [4Fe-4S] core in parent [Fe4S4(SEt)4]2-. The products were first observed in the experiments with an ESI-ion Trap-TOF mass spectrometer and were further identified using high resolution Fourier transform ion cyclotron resonance (FTICR) mass spectrometer. Photoelectron spectra of the [Fe4S4(SEt)4-x(SSEt)x]2- dianions revealed that the -SSEt coordination induced little change in the electronic structure of the [4Fe-4S] cluster, but the electron binding energies of [Fe4S4(SEt)4-x(SSEt)x]2- increased from 0.52 to 0.73 eV with increase in x from 0 to 4, suggesting a greater electron withdrawing ability of -SSEt than -SEt. In high resolution MS/MS experiments on [Fe4S4(SEt)3(SSEt)]2-/1-, clusters with both charge states yielded fragment [Fe4S4(SEt)3]-, suggesting that -SSEt could be lost either as a negatively charged ion SSEt- from the doubly charged precursor, or as a radical SSEt from the singly charged species. The biological implication of the interaction between [Fe4S4(SEt)4]2- and O2 is discussed in comparison to the air exposure of [4Fe-4S] proteins to the air.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Safronova, U. I.; Safronova, A. S.; Beiersdorfer, P.

Energy levels, radiative transition probabilities, and autoionization rates for [Ni]more » $$4{s}^{2}4{p}^{6}{nl}$$, [Ni]$$4{s}^{2}4{p}^{5}4l^{\\prime} {nl}$$ ($$l^{\\prime} =d,f,n$$ = 4–7), [Ni]$$4s4{p}^{6}4l^{\\prime} {nl}$$, ($$l^{\\prime} =d,f,n$$ = 4–7), [Ni]$$4{s}^{2}4{p}^{5}5l^{\\prime} {nl}$$ (n = 5–7), and [Ni]$$4s4{p}^{6}6l^{\\prime} {nl}$$ (n = 6–7) states in Rb-like tungsten (W37+) are calculated using the relativistic many-body perturbation theory method (RMBPT code) and the Hartree–Fock-relativistic method (COWAN code). Autoionizing levels above the [Ni]$$4{s}^{2}4{p}^{6}$$ threshold are considered. It is found that configuration mixing among [Ni]$$4{s}^{2}4{p}^{5}4l^{\\prime} {nl}$$ and [Ni]$$4s4{p}^{6}4l^{\\prime} {nl}$$ plays an important role for all atomic characteristics. Branching ratios relative to the first threshold and intensity factors are calculated for satellite lines, and dielectronic recombination (DR) rate coefficients are determined for the [Ni]$$4{s}^{2}4{p}^{6}{nl}$$ (n = 4–7) singly excited states, as well as the [Ni]$$4{s}^{2}4{p}^{5}4{dnl}$$, [Ni]$$4{s}^{2}4{p}^{5}4{fnl}$$, [Ni]$$4s4{p}^{6}4{dnl}$$, [Ni]$$4{s}^{2}4{p}^{6}4{fnl}$$, (n = 4–6), and [Ni]$$4{s}^{2}4{p}^{5}5l^{\\prime} 5l$$ doubly excited nonautoionizing states in Rb-like W37+ ion. Contributions from the [Ni]$$4s24{p}^{6}4{fnl}$$ (n = 6–7), [Ni]$$4{s}^{2}4{p}^{5}5l^{\\prime} {nl}$$ (n = 5–6), and [Ni]$$4{s}^{2}4{p}^{5}6l^{\\prime} {nl}$$ (n = 6–7) doubly excited autoionizing states are evaluated numerically. The high-n state (with n up to 500) contributions are very important for high temperatures. These contributions are determined by using a scaling procedure. Synthetic dielectronic satellite spectra from Rb-like W are simulated in a broad spectral range from 8 to 70 Å. Here, these calculations provide highly accurate values for a number of W 37+ properties useful for a variety of applications including for fusion applications.« less

Transformation of dinitrosyl iron complexes [(NO)2Fe(SR)2]- (R = Et, Ph) into [4Fe-4S] Clusters [Fe4S4(SPh)4]2-: relevance to the repair of the nitric oxide-modified ferredoxin [4Fe-4S] clusters.

PubMed

Tsou, Chih-Chin; Lin, Zong-Sian; Lu, Tsai-Te; Liaw, Wen-Feng

2008-12-17

Transformation of dinitrosyl iron complexes (DNICs) [(NO)(2)Fe(SR)(2)](-) (R = Et, Ph) into [4Fe-4S] clusters [Fe(4)S(4)(SPh)(4)](2-) in the presence of [Fe(SPh)(4)](2-/1-) and S-donor species S(8) via the reassembling process ([(NO)(2)Fe(SR)(2)](-) --> [Fe(4)S(3)(NO)(7)](-) (1)/[Fe(4)S(3)(NO)(7)](2-) (2) --> [Fe(4)S(4)(NO)(4)](2-) (3) --> [Fe(4)S(4)(SPh)(4)](2-) (5)) was demonstrated. Reaction of [(NO)(2)Fe(SR)(2)](-) (R = Et, Ph) with S(8) in THF, followed by the addition of HBF(4) into the mixture solution, yielded complex [Fe(4)S(3)(NO)(7)](-) (1). Complex [Fe(4)S(3)(NO)(7)](2-) (2), obtained from reduction of complex 1 by [Na][biphenyl], was converted into complex [Fe(4)S(4)(NO)(4)](2-) (3) along with byproduct [(NO)(2)Fe(SR)(2)](-) via the proposed [Fe(4)S(3)(SPh)(NO)(4)](2-) intermediate upon treating complex 2 with 1.5 equiv of [Fe(SPh)(4)](2-) and the subsequent addition of 1/8 equiv of S(8) in CH(3)CN at ambient temperature. Complex 3 was characterized by IR, UV-vis, and single-crystal X-ray diffraction. Upon addition of complex 3 to the CH(3)CN solution of [Fe(SPh)(4)](-) in a 1:2 molar ratio at ambient temperature, the rapid NO radical-thiyl radical exchange reaction between complex 3 and the biomimetic oxidized form of rubredoxin [Fe(SPh)(4)](-) occurred, leading to the simultaneous formation of [4Fe-4S] cluster [Fe(4)S(4)(SPh)(4)](2-) (5) and DNIC [(NO)(2)Fe(SPh)(2)](-). This result demonstrates a successful biomimetic reassembly of [4Fe-4S] cluster [Fe(4)S(4)(SPh)(4)](2-) from NO-modified [Fe-S] clusters, relevant to the repair of DNICs derived from nitrosylation of [4Fe-4S] clusters of endonuclease III back to [4Fe-4S] clusters upon addition of ferrous ion, cysteine, and IscS.

Boundary Layer Dust Occurrence IV Atmospheric Dust Over Selected Geographical Areas

DTIC Science & Technology

1977-06-01

Sariang, Thailand 4 Barcelona, Venezuela 4 Bari/Palese Macchie, Italy 4 75 Index (cont) Name and Country Table (s) Barranquilla/Soledad, Colombia 4...Denmark 4 Bogota/El Dorado, Colombia 4 Bolzano, Italy 4 Bonifati, Italy 4 Botosani, Rumania 4 Bougouni, Mali 4 Boutilimit, Mauritania 1, 22...West Germany 4 Friedrichshafen, West Germany 4 Galati, Rumania 4 Gao, Mali 1,8 Geneva/Cointrin, Switzerland 4 Girardot, Colombia 4 Gorlitz, East

Generation and collision-induced dissociation of ammonium tetrafluoroborate cluster ions.

PubMed

Dain, Ryan P; Van Stipdonk, Michael J

2008-07-01

Singly and doubly charged cluster ions of ammonium tetrafluoroborate (NH4BF4) with general formula [(NH4BF4)nNH4]+ and [(NH4BF4)m(NH4)2]2+, respectively, were generated by electrospray ionization (ESI) and their fragmentation examined using collision-induced dissociation (CID) and ion-trap tandem mass spectrometry. CID of [(NH4BF4)nNH4]+ caused the loss of one or more neutral NH4BF4 units. The n = 2 cluster, [(NH4BF4)2NH4]+, was unique in that it also exhibited a dissociation pathway in which HBF4 was eliminated to create [(NH4BF4)(NH3)NH4]+. Dissociation of [(NH4BF4)m(NH4)2]2+ occurred through two general pathways: (a) 'fission' to produce singly charged cluster ions and (b) elimination of one or more neutral NH4BF4 units to leave doubly charged product ions. CID profiles, and measurements of changing precursor and product ion signal intensity as a function of applied collision voltage, were collected for [(NH4BF4)nNH4]+ and compared with those for analogous [(NaBF4)nNa]+ and [(KBF4)nK]+ ions to determine the influence of the cation on the relative stability of cluster ions. In general, the [(NH4BF4)nNH4]+ clusters were found to be easier to dissociate than both the sodium and potassium clusters of comparable size, with [(KBF4)nK]+ ions the most difficult to dissociate.

Prime Contractors with Awards Over $25,000 by Name, Location, and Contract Number. Fiscal Year 1993. (1079 Construction Corp-Centre Manufacturing Co Inc.). Part 1

DTIC Science & Technology

1994-03-01

EZ 8 44 1- 1.. z 4L ZP u u 0 w Pa8 d 4i) 0 4.z’ 04 ~u 0 4 ) 4.~0 0:. 0W .w- w A.0 tD U.4 0) 0 4 4 4 0W IEu 40 IA. 0 W 42 4n z 4E ww W ta U4 m 4 4 U L...N 0 0kI ~II~(~ ( ~0~c ~IC I N I~(~I~0 01C 4 N( 04i..4 II .4 󈧄W00 IC0 Q 44 -4 0ൈ 00 00 0 1 .Z0 0 00ZZ 4 Is,00 00 0 0 ZI0I wc > 0 3a I Q I4b oo...1 m 3t 024.223 E g r 𔃺 4 to wi L8 z- z . 4L c o Wm 4l H z " E. w 0~ 4lL 44 W a U3 TD W xP 4 j 4 ) W V) F-4 4 4 1 w2 C. : 40 ’s U Q IN 0 1 0 0 0 0

Geographic List of Prime Contract Awards. Oct 91 - Sep 92. FY92. (Utica New York - Copan Oklahoma)

DTIC Science & Technology

1993-01-01

0 0 NISNN ISUSI0001 i 4 4 4 4 4 . is 000i z2 L 4 ZZZ2zzzzzzz 00 2 000V is -S -4 00=- 55 N4 N 4.N -4 .-4 N * LaJ 00( 11 N Z 2-6 zN ZN.. Z 4 ZN Z...qN0 is 0) .-. M0 in P- 4P 55 -44- 1-O-0( P, P- r, 11r-w-f’- * N-4 0- NO4" is q oo I-. 1-. -4 -4 4,4 14w- N -4 Go c000 N 41 I C-SO is 0 0 0 0 40...00000000000000 00 M00000000000000 M M M -4"<J05 M0- (400 55 ,ZNNZCZZCZZZZZZZZ’Z4C’JZZZZZZZZ NZZZZZZ𔃾 .1CC 01[0-TMM -Nf . 0 0-4w(to4 55 LALA L AOLOLO00

Prime Contractors with Awards Over $25,000 by Name, Location, and Contract Number. Fiscal Year 1993. (Lytron Incorporated-Quest Integrated). Part 4

DTIC Science & Technology

1994-03-01

I QQ Q 0 0 @ NN N@0 Q 0 Q QO a 0 (n . 4140 m 0 C-2 a %n mN N N ~ N N U 00 I 00 A 43N~ 4,11 VA 4y 0I a, *I a.f~ 0.0 a, a,4 a- 0 % 0N N (IA01.-4 Ca a...qoi ni 4V m I I I -4 .0 m m IN C : 101 C, 00N1 E II 4 A .4 IN U 0I1 0 Q N40 C44 NO .4 00 a0 0 114 Owa 06 0 0 I$ me 10-0 -0 0 001I . 4140 -IS 4 ’t 0601...4 I .4 -4 4 to -i 4 4~ a. .4 6 60 I414 ~ 4 6 64 1. CO 3 I5 I xi 1 1 4E M 4 t)c nA I ~ I 4* 4 .4 .~. I l44 40 44 1 43 1 1.4 44 . 4 46 4 44116 3~ 4140

REMBASS Commandability. Trade Off Analysis (TOA)/Trade Off Determination (TOD)

DTIC Science & Technology

1977-12-15

3 " 1 0 r-4 V) C-H ) 4-4 4-) 9 4 4- q)$- G C C) P U4J~4 0 4)rz Q1 ’ :;l CZt 4- -4 > E Cd P4r 4 .+ 0. 0 co a) u~f V) UA0 G + ZU) <D +J U) ’-I 4 4-4...i I- . .I I .... . ..... . . .... ... .. . . .. . .... ; = = r ; - *~rj ~*r r P55 - U i- :t4 1 SA" I I-I * I,. " aF " -- UP*5 6...to LC)LO n O L L LnLf LOCL0 3 .L) C’- LuJE4 V)I )L nLIV)tX:X af -VC / "*.-n = CO ccccccca oC . O C,-oCor-.oC CCaOC) tCM W 4WMwC o nU) MWO 4- 4. 4-) 0.-U

The ternary system K2SO4MgSO4CaSO4

USGS Publications Warehouse

Rowe, J.J.; Morey, G.W.; Silber, C.C.

1967-01-01

Melting and subsolidus relations in the system K2SO4MgSO4CaSO4 were studied using heating-cooling curves, differential thermal analysis, optics, X-ray diffraction at room and high temperatures and by quenching techniques. Previous investigators were unable to study the binary MgSO4CaSO4 system and the adjacent area in the ternary system because of the decomposition of MgSO4 and CaSO4 at high temperatures. This problem was partly overcome by a novel sealed-tube quenching method, by hydrothermal synthesis, and by long-time heating in the solidus. As a result of this study, we found: (1) a new compound, CaSO4??3MgSO4 (m.p. 1201??C) with a field extending into the ternary system; (2) a high temperature form of MgSO4 with a sluggishly reversible inversion. An X-ray diffraction pattern for this polymorphic form is given; (3) the inversion of ??-CaSO4 (anhydrite) to ??-CaSO4 at 1195??C, in agreement with grahmann; (1) (4) the melting point of MgSO4 is 1136??C and that of CaSO4 is 1462??C (using sealed tube methods to prevent decomposition of the sulphates); (5) calcium langbeinite (K2SO4??2CaSO4) is the only compound in the K2SO4CaSO4 binary system. This resolved discrepancies in the results of previous investigators; (6) a continuous solid solution series between congruently melting K2SOP4??2MgSO4 (langbeinite) and incongruently melting K2SO4??2CaSO4 (calcium langbeinite); (7) the liquidus in the ternary system consists of primary phase fields of K2SO4, MgSO4, CaSO4, langbeinite-calcium langbeinite solid solution, and CaSO4??3MgSO4. The CaSO4 field extends over a large portion of the system. Previously reported fields for the compounds (K2SO4??MgSO4??nCaSO4), K2SO4??3CaSO4 and K2SO4??CaSO4 were not found; (8) a minimum in the ternary system at: 740??C, 25% MgSO4, 6% CaSO4, 69% K2SO4; and ternary eutectics at 882??C, 49% MgSO4, 19% CaSO4, 32% K2SO4; and 880??, 67??5% MgSO4, 5% CaSO4, 27??5% K2SO4. ?? 1967.

Global Ocean Tides. Part X. The Fortnightly Lunar Tide (Mf) Atlas of Tidal Charts and Maps.

DTIC Science & Technology

1982-02-01

P7 ............................. w ’q NN t 4OP7*404 0 %4......Ob0𔃺𔃺󈧄.44 4440 Co 0P7004 444*4.......0𔃺�P...P.40%4*40 w ~ P7N,..,,,,*, 0: 0 ~j 7I.ynp~ P7 ONNO N4.4OU OppoCs. P.,0100l 4440 ............................ 4* 4*00 NNONN N.4.4000 0𔃺𔃺P.N44A11l0...ANP)P *4*440’ .4444444**4~4P7P7NN.4.4.4C0𔃺𔃾CN44444*4Ř I- * I .0 ANN") *4*~444444~444*4 * P7 ")NNN.4.4dl0󈧄.4444 44*0 o A r 0’ .004.4NNNA*44fl44044

Prime Contract Awards Alphabetically by Contractor, by State or Country, and Place. Part 1. (102 Construction, Inc.-American National Management)

DTIC Science & Technology

1989-01-01

KTN M4 I- M MN 0 .1-4 4 r-ON- a N r-r- 00 ’- 400 N- cma 0C00 N PN- (0 *mm" 44)- I nI 40 4 , , , 1 -4 w - 1-4 m N -4 N~ Moo0 U, 0)IIO0 I ( -4 N C1) -40...0 -4 If 40M( II, 0. 0t 4 M 00m 0.-40-4 a- 0 C-4"ONNN00 - 400 4T Nl oil I 05( 1 C, 0 -. 1i 0D -4C >C -40 -4-4--4 -4 -4- 40 -40C>-J! 0-1 0 0>~I 51 I...0 40 If 0 10 M I I 0> InaO< < 4n 444U U’)nU"UU oU 40 CON ( D0a C>Q 0- r0 ?- NUn 11 < CO-4 II CI >0 0 - - 400 - "-4 - 4-0 4 0 >-0) O)N t I 41110 -4 If

Prime Contract Awards by State, County, Contractor and Place. Fiscal Year 1992. (October - September). North Carolina thru Wyoming

DTIC Science & Technology

1993-01-01

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78 FR 64971 - Endangered and Threatened Species; Permits Issued

Federal Register 2010, 2011, 2012, 2013, 2014

2013-10-30

.../8/13 2/7/16 EAST BAY ZOOLOGICAL SOCIETY 85448A 4/5/13 4/4/16 SHANAHAN, SETH A 231424 4/5/13 4/4/16.../13 4/4/17 HAGAR ENVIRONMENTAL SCIENCE 089980 4/12/13 4/11/17 OBERHOFF, DWAYNE N 180579 4/12/13 4/11...

Combinatorial Geometry Computer Models of Sitting and Standing Crew Personnel

DTIC Science & Technology

1981-08-01

Anthropometry - 1976,11 US Army Natick Laboratories Technical Report No. 72-51-CE, December, 1971. 10 4-). 0 4-3 4-3 =- -mr - 4. . 0 C- 4- WW~ C0 0 4...t.4IwI-4S-4 4A Vs x 1-4~ i-I a~ 4 >- *E0. .- ~-- I- u ~.Iz 4 www ou u0 W(. cc 0 I- I-W OW(AWWW Wj oz 0 WW4 X XL U. WEE.-J. d- 1.4 o ZZ W W w LL to4W0

Data Analysis in Vocational/Technical (VOTEC) Manpower and Personnel Studies

DTIC Science & Technology

1993-03-24

5 3Label NUB + **- ------- ------------ ---- 4~ v s 64 V 6 65 SUM6 71 V 2...59 2 5 2 2 4I 21 2 4 260o 41 4 4 41 1 41 4 41 4 3 61 21 11 I II 62 1 1 1 1 1 3 631 50 43 41 21 2 1 32 42 21 21 - 64, 5 ! 5 ! S! 5 4 ! 5 5 : 5 3 . s 65 6...8217 51 5 3 4 4 5 51 t1 4 41 6 31 6 5 5 . 4 4 3 4’ 1 45 4 41 4 4 51 4 3 3 4 4 21 5 3 3 61 5 sI 5 5 41 S S s 71i 41 41 43 Si S 5

Serosal Cavities Contain Two Populations of Innate-like integrin α4highCD4+ T Cells, Integrin α4β1+α6β1+α4β7- and α4β1+α6β1-α4β7+ Cells.

PubMed

Yang, Jeong In; Park, Chanho; Kho, Inseong; Lee, Sujin; Suh, Kyung-Suk; Kim, Tae Jin

2017-12-01

We previously reported peritoneal innate-like integrin α4 (CD49d) high CD4 + T cells that provided help for B-1a cells. Here we analyzed the expression of various integrin chains on the peritoneal and pleural integrin α4 high CD4 + T cells and investigated the functional heterogeneity of the subpopulations based on the integrin expression. Pleural cavity contained a lower ratio of integrin α4 high CD4 + T cells to integrin α4 low CD4 + T cells than peritoneal cavity, but the pleural integrin α4 high CD4 + T cells have the same characteristics of the peritoneal integrin α4 high CD4 + T cells. Most of integrin α4 high CD4 + T cells were integrin β1 high β7 - , but a minor population of integrin α4 high CD4 + T cells was integrin β1 + β7 + . Interestingly, the integrin α4 high β1 high β7 - CD4 + T cells expressed high levels of integrin α4β1 and α6β1, whereas integrin α4 high β1 + β7 + CD4 + T cells expressed high levels of integrin α4β1 and α4β7, suggesting an alternative expression of integrin α6β1 or α4β7 in combination with α4β1 in respective major and minor populations of integrin α4 high CD4 + T cells. The minor population, integrin α4 high β1 + β7 + CD4 + T cells, were different from the integrin α4 high β1 high β7 - CD4 + T cells in that they secreted a smaller amount of Th1 cytokines upon stimulation and expressed lower levels of Th1-related chemokine receptors CCR5 and CXCR3 than the integrin α4 high β 1 high β 7 - CD4 + T cells. In summary, the innate-like integrin α4 high CD4 + T cells could be divided into 2 populations, integrin α4β1 + α6β1 + α4β7 - and α4β1 + α6β1 - α4β7 + cells. The functional significance of serosal integrin α4β7 + CD4 + T cells needed to be investigated especially in view of mucosal immunity.

Dollar Summary of Federal Supply Classification and Service Category by Company. Part 5 (1005-4810)

DTIC Science & Technology

1991-01-01

L - U . > . > - > L U - > -L - <~~~~ a a L<>>> ><x< <xX< CL~~~~ a . a 0 <<< < 0 w0 0 w = Oi ( >4 -4 .1- zaw 4) - 4 0 0 .4 c0 0a Uo aa-a 4 w cc aw Co a...2)-) 1- m 0 tun t" 0 . w - 0 LU 14 r L U ) 0 D ) 1~ 0. )- 4 -14 Z 14 4 > 0 a o4 5l -c w4 w4 w ~ 00) m) -4 0 C, on N 0 O N40 0 N Nl co " -4 4 m~ sLn 00...II 0 I 4W 4W W -.4 -.4 0 .4 L 4 0 1- I ) -4- C)I I a - W go~~ I W >- ᝾ _j 1: tun I ~ ~ ~ ~ ~ ~ ~ ~ ~ ~ ~ 4 I -)r c0 - 0 - (0 D ONt -4 0 m) 0 0 C0

All Prime Contract Awards by State or Country, Place and Contractor. Part 1. (Alexander City, Alabama-Sevier, Arkansas)

DTIC Science & Technology

1989-01-01

Kf 0-4 a -54 -4.4.4 -4 4 -0 w.4 (0 c 0 W.4 0(0c 0.4 Oafs Oafs 0o l- Kom 0 ene (04 Kn m0 m 00000000 C2,40-4 0cr 00 ON4 on 00 00 to (04t KfC 4C N N...0 m-4 CD-C C00 N on VN Nli00 410-IOCD N In 4N T10 N0 01 C- 004 or-, 0)0-4-400V) 004- 00 -4 Infin I I C -C1 I4N Nf r- CY) 00 N-4 1-’ M 00 CO COO -4

A Comparison of Two Acoustic Parabolic Transmisssion Loss Models for Compatibility with the Wavenumber Technique in the Determination of Source Depth.

DTIC Science & Technology

1984-03-01

4 ~ L04 z 0 C) A L- L- - U)NN. 4 0 N 0QzP4L~ (iO m tn HL-4, "Ŕs~4 bn (/) L- U) 44C U )~ H W .WE- L C 04 Ql= H . L- HlA ~~~E- 0=000-~~0 0.N 4 ~U NOSmi...4*44* *4** *444 4* 4 Wz -u >* Pi -. ,: L 4 H 4 Q H~- --~ * H E - 0W 4 adI 0 0n :U -" 4 4% U 1 (n t F-4 1042 = *4 *- 44-, w Hl~w 4&4 *-- i* U E E- r 44

All Prime Contract Awards by State or Country, Place, and Contractor, FY 88. Part 23. (Greenland-Morocco)

DTIC Science & Technology

1988-01-01

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Anthropometric Survey of the Imperial Iranian Armed Forces. Volume 2. Statistical Data

DTIC Science & Technology

1971-03-01

nI JIni D D 0c41 1. 4n Lk MN ~ LAMO NOO’O-0’r4 -4 ’t 4 ~ ý N-*I4Lr- -44 o.L .4 - o N"-4 0 4lA in0. coN -4. -4 . 41 Go N- -4 0 - 0 0LINA .4 4 P.4LA...m -4 0r o40 r4 C4 N 0 - -n 0 ’-40 t . . 41 .-. 4, d O - .0tiI-P .- A -n 0 N m a,4( 0 gao Mr .’m00 < OD r- mo N~ m,- (314- 0 0.0C l i O ~ j - 000 04 m

Two related trypanosomatid eIF4G homologues have functional differences compatible with distinct roles during translation initiation

PubMed Central

Moura, Danielle MN; Reis, Christian RS; Xavier, Camila C; da Costa Lima, Tamara D; Lima, Rodrigo P; Carrington, Mark; de Melo Neto, Osvaldo P

2015-01-01

In higher eukaryotes, eIF4A, eIF4E and eIF4G homologues interact to enable mRNA recruitment to the ribosome. eIF4G acts as a scaffold for these interactions and also interacts with other proteins of the translational machinery. Trypanosomatid protozoa have multiple homologues of eIF4E and eIF4G and the precise function of each remains unclear. Here, 2 previously described eIF4G homologues, EIF4G3 and EIF4G4, were further investigated. In vitro, both homologues bound EIF4AI, but with different interaction properties. Binding to distinct eIF4Es was also confirmed; EIF4G3 bound EIF4E4 while EIF4G4 bound EIF4E3, both these interactions required similar binding motifs. EIF4G3, but not EIF4G4, interacted with PABP1, a poly-A binding protein homolog. Work in vivo with Trypanosoma brucei showed that both EIF4G3 and EIF4G4 are cytoplasmic and essential for viability. Depletion of EIF4G3 caused a rapid reduction in total translation while EIF4G4 depletion led to changes in morphology but no substantial inhibition of translation. Site-directed mutagenesis was used to disrupt interactions of the eIF4Gs with either eIF4E or eIF4A, causing different levels of growth inhibition. Overall the results show that only EIF4G3, with its cap binding partner EIF4E4, plays a major role in translational initiation. PMID:25826663

High-level ab initio predictions for the ionization energies and heats of formation of five-membered-ring molecules: thiophene, furan, pyrrole, 1,3-cyclopentadiene, and borole, C4H4X/C4H4X+ (X = S, O, NH, CH2, and BH).

PubMed

Lo, Po-Kam; Lau, Kai-Chung

2011-02-10

The ionization energies (IEs) and heats of formation (ΔH°(f0)/ΔH°(f298)) for thiophene (C(4)H(4)S), furan (C(4)H(4)O), pyrrole (C(4)H(4)NH), 1,3-cyclopentadiene (C(4)H(4)CH(2)), and borole (C(4)H(4)BH) have been calculated by the wave function-based ab initio CCSD(T)/CBS approach, which involves the approximation to the complete basis set (CBS) limit at the coupled-cluster level with single and double excitations plus a quasi-perturbative triple excitation [CCSD(T)]. Where appropriate, the zero-point vibrational energy correction (ZPVE), the core-valence electronic correction (CV), and the scalar relativistic effect (SR) are included in these calculations. The respective CCSD(T)/CBS predictions for C(4)H(4)S, C(4)H(4)O, C(4)H(4)NH, and C(4)H(4)CH(2), being 8.888, 8.897, 8.222, and 8.582 eV, are in excellent agreement with the experimental values obtained from previous photoelectron and photoion measurements. The ΔH°(f0)/ΔH°(f298) values for the aforementioned molecules and their corresponding cations have also been predicted by the CCSD(T)/CBS method, and the results are compared with the available experimental data. The comparisons between the CCSD(T)/CBS predictions and the experimental values for C(4)H(4)S, C(4)H(4)O, C(4)H(4)NH, and C(4)H(4)CH(2) suggest that the CCSD(T)/CBS procedure is capable of predicting reliable IE values for five-membered-ring molecules with an uncertainty of ±13 meV. In view of the excellent agreements between the CCSD(T)/CBS predictions and the experimental values for C(4)H(4)S, C(4)H(4)O, C(4)H(4)NH, and C(4)H(4)CH(2), the similar CCSD(T)/CBS IE and ΔH°(f0)/ΔH°(f298) predictions for C(4)H(4)BH, whose thermochemical data are not readily available due to its reactive nature, should constitute a reliable data set. The CCSD(T)/CBS IE(C(4)H(4)BH) value is 8.868 eV, and ΔH°(f0)/ΔH°(f298) values for C(4)H(4)BH and C(4)H(4)BH(+) are 269.5/258.6 and 1125.1/1114.6 kJ/mol, respectively. The highest occupied molecular orbitals (HOMO) of C(4)H(4)S, C(4)H(4)O, C(4)H(4)NH, C(4)H(4)CH(2), and C(4)H(4)BH have also been studied by the natural bond orbital (NBO) method, and the extent of π-electron delocalization in these five-membered rings are discussed in correlation with their molecular structures and orbitals.

National Dam Inspection Program. Baggaley Dam. (NDI Number PA-00454, PennDER Number-65-10) Ohio River Basin, Indian Camp Run, Westmoreland County, Pennsylvania. Phase I Inspection Report.

DTIC Science & Technology

1980-05-01

o U)q) ) C o ’--I o 2m)U c = 00 -1 a o 4 0 r-4 C 0 o4.) -C)L 0 bo3 0Q) 4 S .) * -ObO -) "a ) - 4C )j 0 04- >4. = M.- Q C) Q) D a al~. 9)C) 4)a ) C)2. Q...Z1 ocacr. . 1 xm j. )( E- 2 9) . ,> ( 1 - - 4C 0 .1a () 4 CZ3 0 = > 0 C E bo to a 4 Lca A3 0- 0 (d 2 0 -4 o 00 (a C-) "-I wz X .4 0 0I X: 0 cc 1) E (UG4...C L (DU) 4)0L r-4 4C ~ ) 0 0 r.1 V 4 LO0U0 0dv 04) 40 V0.0 0 m cC -4 X V 4 c4.) 4.3 3 4) ) -q .) -f .4to V 41 4.) 02 0 C tv 0c c C .4) 0a 0 9) In-4 0

DOE Office of Scientific and Technical Information (OSTI.GOV)

Ben Yahia, Hamdi, E-mail: benyahia.hamdi@voila.fr; Rodewald, Ute Ch.; Boulahya, Khalid

Graphical abstract: The new compounds RE{sub 4}O{sub 4}[AsO{sub 4}]Cl (RE = La, Pr, Nd, Sm, Eu, Gd) were synthesised by solid state reaction via a salt flux route and investigated by HRTEM, SAED, and single crystal X-ray diffraction. - Highlights: • We discovered the series of RE{sub 4}O{sub 4}[AsO{sub 4}]Cl (RE = La, Pr, Nd, Sm, Eu, Gd) compounds. • The RE{sub 4}O{sub 4}[AsO{sub 4}]Cl single crystals were grown using NaCl/KCl flux. • The RE{sub 4}O{sub 4}[AsO{sub 4}]Cl structures were solved using single crystal X-ray diffraction data. • The layered RE{sub 4}O{sub 4}[AsO{sub 4}]Cl compounds were further characterized using HRTEMmore » and SAED. • We observed an alternation of ordered-[RE{sub 4}O{sub 4}]{sup 4+} and disordered-[ClAsO{sub 4}]{sup 4–} layers. - Abstract: The new compounds RE{sub 4}O{sub 4}[AsO{sub 4}]Cl (RE = La, Pr, Nd, Sm, Eu, Gd) were synthesised by solid state reaction via a salt flux route and investigated by HRTEM, SAED, and single crystal X-ray diffraction. The samples crystallise with a tetragonal cell, space group P4{sub 2}/mnm and Z = 2. Their crystal structure consists of an alternation of [RE{sub 4}O{sub 4}]{sup 4+} and [ClAsO{sub 4}]{sup 4–} layers. The [RE{sub 4}O{sub 4}]{sup 4+} layer contains ORE{sub 4/4} tetrahedra which share common edges. The anions AsO{sub 4}{sup 3–} and Cl{sup –} are located between these layers in disordered manner. SAED and HRTEM experiments confirmed this structural model and enabled us to propose an ordered model for the [ClAsO{sub 4}]{sup 4–} layers.« less

User’s Manual for the Generalized Computer Program System Open-Channel Flow and Sedimentation TABS-2. Main Text and Appendices A through O.

DTIC Science & Technology

1985-08-01

American Society of Civil Engineers,, No. HYIL. Ariathurai, R. 1974 (Aug). A Finite Element Model for Sediment Transport in Estuaries, Ph. D. Thesis ...11 aml ms po GR PH C 1.2 ś, I i 2 "’-..04/85 a I -- . a.., 4 4 - 4 I --.. - £ . ,. 04/85 4 444 4 9*4*4449 444 A4 A44 4 4 4 4 4 4 * 4 44 4 4 4 p 4...VEL MAGNITUDE (HOURS) CFT /SEC) (FT/SEC) (F/SEC) (FT) (FT) STATUS (FiSEC) (FT/SEC) (FT/SEC) .00 -. 115 -. 043 -. 123 5.501 100.507 MET -. 112 -. 069

Limited Surface Observations Climatic Summary (LISOCS) Bad Kreuznach AAF Germany.

DTIC Science & Technology

1988-02-01

GE GE GE GE GE GE FEET I IsO 90 80 61 48 𔃾 32 24 2G 16 12 10 8 5 4 0 NO CEIL 1 33.9 35.1 37.4 40.1 40.1 4n.1 40.4 40.4 40.4 40.4 40.4 40.4 40.4 40.4...93.3 93.3 93.3 93.3 93.3 93.3 93.3 GE 27001 68.6 75.1 88.1 94.9 96.1 96.6 97.2 97.2 97.4 97.4 97.4 97.4 97.4 97.4 97.4 GE Iei 1 68.6 75.1 88.1 94.9

The unique Leishmania EIF4E4 N-terminus is a target for multiple phosphorylation events and participates in critical interactions required for translation initiation.

PubMed

de Melo Neto, Osvaldo P; da Costa Lima, Tamara D C; Xavier, Camila C; Nascimento, Larissa M; Romão, Tatiany P; Assis, Ludmila A; Pereira, Mariana M C; Reis, Christian R S; Papadopoulou, Barbara

2015-01-01

The eukaryotic initiation factor 4E (eIF4E) recognizes the mRNA cap structure and, together with eIF4G and eIF4A, form the eIF4F complex that regulates translation initiation in eukaryotes. In trypanosomatids, 2 eIF4E homologues (EIF4E3 and EIF4E4) have been shown to be part of eIF4F-like complexes with presumed roles in translation initiation. Both proteins possess unique N-terminal extensions, which can be targeted for phosphorylation. Here, we provide novel insights on the Leishmania infantum EIF4E4 function and regulation. We show that EIF4E4 is constitutively expressed throughout the parasite development but is preferentially phosphorylated in exponentially grown promastigote and amastigote life stages, hence correlating with high levels of translation. Phosphorylation targets multiple serine-proline or threonine-proline residues within the N-terminal extension of EIF4E4 but does not require binding to the EIF4E4's partner, EIF4G3, or to the cap structure. We also report that EIF4E4 interacts with PABP1 through 3 conserved boxes at the EIF4E4 N-terminus and that this interaction is a prerequisite for efficient EIF4E4 phosphorylation. EIF4E4 is essential for Leishmania growth and an EIF4E4 null mutant was only obtained in the presence of an ectopically provided wild type gene. Complementation for the loss of EIF4E4 with several EIF4E4 mutant proteins affecting either phosphorylation or binding to mRNA or to EIF4E4 protein partners revealed that, in contrast to other eukaryotes, only the EIF4E4-PABP1 interaction but neither the binding to EIF4G3 nor phosphorylation is essential for translation. These studies also demonstrated that the lack of both EIF4E4 phosphorylation and EIF4G3 binding leads to a non-functional protein. Altogether, these findings further highlight the unique features of the translation initiation process in trypanosomatid protozoa.

The unique Leishmania EIF4E4 N-terminus is a target for multiple phosphorylation events and participates in critical interactions required for translation initiation

PubMed Central

de Melo Neto, Osvaldo P; da Costa Lima, Tamara D C; Xavier, Camila C; Nascimento, Larissa M; Romão, Tatiany P; Assis, Ludmila A; Pereira, Mariana M C; Reis, Christian R S; Papadopoulou, Barbara

2015-01-01

The eukaryotic initiation factor 4E (eIF4E) recognizes the mRNA cap structure and, together with eIF4G and eIF4A, form the eIF4F complex that regulates translation initiation in eukaryotes. In trypanosomatids, 2 eIF4E homologues (EIF4E3 and EIF4E4) have been shown to be part of eIF4F-like complexes with presumed roles in translation initiation. Both proteins possess unique N-terminal extensions, which can be targeted for phosphorylation. Here, we provide novel insights on the Leishmania infantum EIF4E4 function and regulation. We show that EIF4E4 is constitutively expressed throughout the parasite development but is preferentially phosphorylated in exponentially grown promastigote and amastigote life stages, hence correlating with high levels of translation. Phosphorylation targets multiple serine-proline or threonine-proline residues within the N-terminal extension of EIF4E4 but does not require binding to the EIF4E4's partner, EIF4G3, or to the cap structure. We also report that EIF4E4 interacts with PABP1 through 3 conserved boxes at the EIF4E4 N-terminus and that this interaction is a prerequisite for efficient EIF4E4 phosphorylation. EIF4E4 is essential for Leishmania growth and an EIF4E4 null mutant was only obtained in the presence of an ectopically provided wild type gene. Complementation for the loss of EIF4E4 with several EIF4E4 mutant proteins affecting either phosphorylation or binding to mRNA or to EIF4E4 protein partners revealed that, in contrast to other eukaryotes, only the EIF4E4-PABP1 interaction but neither the binding to EIF4G3 nor phosphorylation is essential for translation. These studies also demonstrated that the lack of both EIF4E4 phosphorylation and EIF4G3 binding leads to a non-functional protein. Altogether, these findings further highlight the unique features of the translation initiation process in trypanosomatid protozoa. PMID:26338184

Excitation energies, radiative and autoionization rates, dielectronic satellite lines, and dielectronic recombination rates for excited states of Rb-like W from Kr-like W [Relativistic atomic data for Rb-like tungsten

DOE PAGES

Safronova, U. I.; Safronova, A. S.; Beiersdorfer, P.

2016-11-02

Energy levels, radiative transition probabilities, and autoionization rates for [Ni]more » $$4{s}^{2}4{p}^{6}{nl}$$, [Ni]$$4{s}^{2}4{p}^{5}4l^{\\prime} {nl}$$ ($$l^{\\prime} =d,f,n$$ = 4–7), [Ni]$$4s4{p}^{6}4l^{\\prime} {nl}$$, ($$l^{\\prime} =d,f,n$$ = 4–7), [Ni]$$4{s}^{2}4{p}^{5}5l^{\\prime} {nl}$$ (n = 5–7), and [Ni]$$4s4{p}^{6}6l^{\\prime} {nl}$$ (n = 6–7) states in Rb-like tungsten (W37+) are calculated using the relativistic many-body perturbation theory method (RMBPT code) and the Hartree–Fock-relativistic method (COWAN code). Autoionizing levels above the [Ni]$$4{s}^{2}4{p}^{6}$$ threshold are considered. It is found that configuration mixing among [Ni]$$4{s}^{2}4{p}^{5}4l^{\\prime} {nl}$$ and [Ni]$$4s4{p}^{6}4l^{\\prime} {nl}$$ plays an important role for all atomic characteristics. Branching ratios relative to the first threshold and intensity factors are calculated for satellite lines, and dielectronic recombination (DR) rate coefficients are determined for the [Ni]$$4{s}^{2}4{p}^{6}{nl}$$ (n = 4–7) singly excited states, as well as the [Ni]$$4{s}^{2}4{p}^{5}4{dnl}$$, [Ni]$$4{s}^{2}4{p}^{5}4{fnl}$$, [Ni]$$4s4{p}^{6}4{dnl}$$, [Ni]$$4{s}^{2}4{p}^{6}4{fnl}$$, (n = 4–6), and [Ni]$$4{s}^{2}4{p}^{5}5l^{\\prime} 5l$$ doubly excited nonautoionizing states in Rb-like W37+ ion. Contributions from the [Ni]$$4s24{p}^{6}4{fnl}$$ (n = 6–7), [Ni]$$4{s}^{2}4{p}^{5}5l^{\\prime} {nl}$$ (n = 5–6), and [Ni]$$4{s}^{2}4{p}^{5}6l^{\\prime} {nl}$$ (n = 6–7) doubly excited autoionizing states are evaluated numerically. The high-n state (with n up to 500) contributions are very important for high temperatures. These contributions are determined by using a scaling procedure. Synthetic dielectronic satellite spectra from Rb-like W are simulated in a broad spectral range from 8 to 70 Å. Here, these calculations provide highly accurate values for a number of W 37+ properties useful for a variety of applications including for fusion applications.« less

Plant growth and fertility requires functional interactions between specific PABP and eIF4G gene family members

PubMed Central

2018-01-01

The initiation of protein synthesis requires the involvement of the eukaryotic translation initiation factor (eIF) 4G to promote assembly of the factors needed to recruit a 40S ribosomal subunit to an mRNA. Although many eukaryotes express two eIF4G isoforms that are highly similar, those in plants, referred to as eIF4G and eIFiso4G, are highly divergent in size, sequence, and domain organization. Species of the Brassicaceae and the Cleomaceae also express a divergent eIFiso4G isoform, referred to as eIFiso4G2, not found elsewhere in the plant kingdom. Despite their divergence, eIF4G and eIFiso4G interact with eIF4A, eIF4B, and eIF4E isoforms needed for binding an mRNA. eIF4G and eIFiso4G also interact with the poly(A)-binding protein (PABP) which promotes ribosome recruitment to an mRNA. Increasing the complexity of such an interaction, however, Arabidopsis also expresses three PABP isoforms (PAB2, PAB4, and PAB8) in vegetative and reproductive tissues. In this study, the functional interactions among the eIF4G and the widely-expressed PABP isoforms were examined. Loss of PAB2 or PAB8 in combination with loss of eIF4G or eIFiso4G had little to no effect on growth or fertility whereas pab2 pab8 eif4g or pab2 pab8 eifiso4g1/2 mutants exhibited smaller stature and reduced fertility. Although the pab4 eifiso4g1 mutant grows normally and is fertile, pab4 eif4g or pab4 eifiso4g2 mutants could not be isolated. Even pab4/PAB4 eif4g/eIF4G heterozygous plants exhibited growth defects and low fertility. Mutant co-inheritance analysis in reciprocal crosses with wild-type plants revealed that most ovaries and pollen from pab4/PAB4 eif4g/eIF4G plants were PAB4 eif4g. Similarly, co-inheritance studies with pab4/PAB4 eifiso4g2/eIFiso4G2 plants suggested most ovaries were PAB4 eifiso4g2. These results suggest that a functional interaction between PAB4 and eIF4G and between PAB4 and eIFiso4G2 is required for growth and normal fertility. PMID:29381712

Prime Contract Awards Over $25,000 by Major System, Contractor and State Part 2 (AVG NAVY-SMR NAVY)

DTIC Science & Technology

1990-01-01

0 oo0 C) C11 in LA -40w’ I (w -4 N’(. N wO C’-4 4 Go I I I I 5 C- LiCl I m -4 . -40 4 9. C 4,44 44to CL 0 -4 0 -4 Ei EE 0 . Ein % - ) O -Oa W> 444 Pn...3t1, U൰ 4C’J -4)C 0 ) U) 0 0 )M.-4-40-04" I4 Z 7-Ci M’ N N00 C D -4 -4I-4Z4 3:JU I )-( C13- 0 3 )000f 0 ’U) in in i "~ 0 -a < 101ui0 5 -4 O L)- 0 ...M4)u . 0 4W II*-1 4)-- .W0 L-C -4 W I CL. L 0 ) 5 CL a)

Development and Evaluation of Adeno-HTLV-III Hybrid Virus and Non- Cytopathic HTLV-III Mutant for Vaccine Use

DTIC Science & Technology

1988-10-28

I44r.0 + I I U.-4 Io 4- z+ (b I- 0 cj V I-SI: -4 I4 0)~ W4+ I ~ ’ IC14 e 9Q~ 4I cj-0 C:.L SI r. Cl I1C I0 -4 -4 I- .I -.t- 1 J.X- )0 1I 4 I I < < I w ...1-1 0 (3I I >+ ++ >> coZ mI WC ~ + U- H-i m ca IQg OI pI I4 cN.3 I "- .- 00I - I In :3 :3 w w 1 04l ci I I I I I ~ 4(~,-4~4.36 + a% 𔃺 001 to U 4-4...C) l~ u(V14:: - 4L + 4+ bC4 co4 ~0 M~ 40 -40~4. 4.4 bc I0 -l 110 C) 1 0 1 N, o 1) 41 -4 + cn, -H + N- to4 z:: Ia 41 w 1-1+ II,-HI r_ (cc ) (N -a* 1

Prime Contract Awards Alphabetically by Contractor, by State or Country, and Place, FY 88. Part 16. (Prime Mover Company, The-Rodriguez General Contractors)

DTIC Science & Technology

1988-01-01

W WZma t *0r- 0n4 0a 0 00 o W O~ z 00( (04 (0 �W-4 1(300 (3000 z40USr~cn70 acca (0 Z~n Zw zoo zovl0 ZNN""NNwIWO0-4 3.0( 400( .4.) ൰-4-403 000( 0...4-IN 0000 N 00aIN4-aN..o.0-0 0 a 8 MOM 1 -444.4-4400 .40.4 .4 .40100000-40000-480000000.4 0 WI O I00 F6 Go’t=s-r 0 - P. 3. P- f 0 0 ft 0 ft 0 w6ft 0 w...0.4(-0.4 r- 00 -0 0.4.40(0 4(0 r -~((4660t(006na"U)CF 4V蔾 0 D00L6 NNNNC) q 4 l 00:W r 4 00 (0000 I4 -00-4 -4 61L 4 -401 -4 f6 )0)00 00000"fl 4-0 L L

All Prime Contract Awards by State or Country, Place, and Contractor. Part 9 (Annville, Kentucky-Crofton, Maryland)

DTIC Science & Technology

1990-01-01

4.44c V c- U CU4 0 1.- (A 0.0 a* .W - 0. i- -4 C10t- (D I M 6 l UN W 0 >. GN C4 i ae ad )-4N0C, D,0 P. f6 MŔ R~ = 1- (0 00 .8 (A Q 0 0 Zococ3- 00cv I...In 0 P.- CM -4 0 -4 ’I- U u I 000 Go I -16 OC) f6 ’ -4 0A 0 CN - Ll.UC I oo r WNI 00 0 16060 I toN 4: N f 0 L I. I OP.- U -4 -. 4.4 -4 .4.4 .- 46. 4...00 "M M 0i 201(f 1 E00 -4 N)x 0 0 0 Q 0x- 0 0 F6 . Co C4- NI- al 2 0 Wi U) ~ ~ 1. C.) ai a 1 I0 04 N U)N-mN-NN -. 0-4- 1- 4 1.( 4-4 4 (Y00 0 ) -e4 n N

78 FR 56242 - Notice of Realty Action: Competitive Sale of 28 Parcels of Public Land in Clark County, NV

Federal Register 2010, 2011, 2012, 2013, 2014

2013-09-12

... acres: T. 20 S., R. 60 E., Sec. 6, NW\\1/4\\SW\\1/4\\SE\\1/4\\, W\\1/2\\NE\\1/4\\SW\\1/4\\SE\\1/4\\, NE\\1/4\\NE\\1/4\\SW\\1/4\\SE\\1/4\\. N-78190, 2.50 acres: T. 22 S., R. 60 E., Sec. 14, NW\\1/4\\SW\\1/4\\NW\\1/4\\SW\\1/4\\. N-91783, 5.00 acres: T. 22 S., R. 60 E., Sec. 14, S\\1/2\\SW\\1/4\\SW\\1/4\\SW\\1/4\\. N-91794, 10.00 acres: T. 22 S...

Great River Environmental Action Team II. (GREAT II). Upper Mississippi River (Guttenberg, Iowa to Saverton, Missouri). Recreation Work Group. Appendix.

DTIC Science & Technology

1980-12-01

4 1-40 0*r - 04 mr. A-4 A.) 0 00 co 0) r. 4-40 W 1 𔃺Q)0 cc 0 0 .0 0 u 0 U .0 0 0 0 04 0HD 01. 40 A0 1H U) . td p- wu 0c W~ to 0 0.E $U -i 0.4 0w 0...w0 4 0 4) 44 44 0) -4 C: w w . Or,-% 4) ..4 0 ri4 4 w 0 04 1 0-4 " -4 go Q4 v0 0000P 51~N S. C 40 J 0 0 0n v 0 v 0 C -4 )k4 WW0-4 4),- 4bd oo. 4J1 (fl 0

Aviation Officer Requirements Study.

DTIC Science & Technology

1982-08-31

r4444-444,, 44*44 * 4ri OW 4.YP F3 1X Tt FF 1r 1 i.111 * 21’ 1 * 34 FVA r i. i r n -t~I I~’JJ YirF Tz i. * I 4 * F*r_ v" J * f,4 fvA IiGr ti Ic:~ r A...7 F3 0- .- * 4*. * 4,*.&-4 l󈧰*4* 4 ~ *’Ř󈧰 44 4 *44 ’ k 4)* ,_𔃾- 4*4 4 721C 4 PARAMETER CATEGORY MENU SCr(EEN This screen appears af ter screen...0, 4, F3 1*(,I!X vF4./ 13-30 DATA 0, 4, 09, r2, ./ A*AX VAM!/ 1340 DATA 0, P.2 .. 0, P. 0 /*A4L1 VAW " " 13S-0 DATA 2, 4,21,1,5, 2.9 /*ALX VAOP

Theoretical studies on all-metal binuclear sandwich-like complexes M2(η 4-E 4) 2 (M=Al, Ga, In; E=Sb, Bi).

PubMed

Wang, Congzhi; Zhang, Xiuhui; Lu, Jian; Li, Qianshu

2012-08-01

A series of all-metal binuclear sandwich-like complexes with the formula M(2)(η(4)-E(4))(2) (M=Al, Ga, In; E=Sb, Bi) was studied by density functional theory (DFT). The most stable conformer for each of the M(2)(η(4)-E(4))(2) species is the staggered one with D (4d) symmetry. The centred metal-metal bond in each M(2)(η(4)-E(4))(2) species is a covalent single bond, with the main contributors to these covalent bonds being the a(1) and e orbitals. For all these species, the interactions between the centred metal atoms and the all-metal ligands are covalent; η(4)-Sb (4) (2-) has a stronger ability to stabilize metal-metal bonds than η(4)-Bi (4) (2-). Nucleus-independent chemical shifts (NICS) values and molecular orbital (MO) analysis reveal that the all-metal η(4)-Sb (4) (2-) and η(4)-Bi (4) (2-) ligands in M(2)(η(4)-E(4))(2) possess conflicting aromaticity (σ antiaromaticity and π aromaticity), which differs from the all-metal multiple aromatic unit Al (4) (2-). In addition, all of these M(2)(η(4)-E(4))(2) species are stable according to the dissociation energies of M(2)(η(4)-E(4))(2) → 2 M(η(4)-E(4)) and M(2)(η(4)-E(4))(2) → 2 M + 2E(4), and these stable species can be synthesized by two-step substitution reactions: CpZnZnCp + 2E (4) (2-)  → [E(4)ZnZnE(4)](2-) + 2Cp(-) and [E(4)ZnZnE(4)](2-) + 2 M (2) (+)  → E(4)MME(4) + 2Zn(+).

Installation Restoration Program (Sites 1, 2, 3, 4, 5, 8, 13). Phase 4. Remedial Action Plan and Conceptual Documents, Edwards AFB, California

DTIC Science & Technology

1984-11-01

R &D investigations. 1.3 PHASE IV SITE DESCRIPTIONS I Three primary sites are included in this Phase IV...34C z I L . ...- I I E I I i -\\ = _ _ _ . .. .....,. . .. .. I x FIGURE 1.7 a qq"-.. .. .. .. .. .. "- _ r JI I g I I1 ,n I , I I I " I - I Br-.,,-%~l...0 0 4J 4) 44 4) V ) -H 0 4 6: 144 d 0 4 14 404)-4 -4 4 .4 N ) 4 0 4) 𔃾 4 40 4) 4) 0.0

DoD Industrial Security Program

DTIC Science & Technology

1985-12-01

0 0 - a *ju .4 C4 -0a m W4 M (𔃾S P A "-f~%~vs %n P4 M NI N ’ 0 45~~~~ 0 14 fl.-a n0 P 5 4 C4N0’ 0 - 1.4 00i~inn* so6 06 0 ’.4v- C4IS mu 4 0 C...41 (a 0ie $4- P4 V10 ka. " 4 . 10 6C 00 N0%’UPCin’A445 0 It. -.W0 0 4114 uk0 4I. 0 V 3 : 5 a0 - 4; w 00 44U *% 2 -4 0 1 W 0 g *4 0 % 0 0 4-cw9: 6q V4 0 ...a 0 .bI - 0 0

Prime Contract Awards Alphabetically by Contractor, by State or Country, and Place, Fiscal Year 1987. Part 8. General Fire Extinguisher Del.-Hawthorne of Missouri, Incorporated.

DTIC Science & Technology

1987-01-01

0-4 .4n~(D r-4.4.4.--00-4N -4O4N4N Q 103 (n 0 l 0 I I toN (n oC 00 0 000000c000 o 0000 00 4i 0000000000000000000000000 00000000 -0 1I00007mo 00...Ij 0 0 00 0000 0 o 7Ŕ CA 00O Io L) ’- I- 4n (oWI W rh - 4 -4 - "oi Io DO Io .- D 01 4NCA 00 01 n0) 0) 0) z0 NI -4 coo N I3 OO I y)W( -4 -0 -4 4 4 0 0...4 00 00 C’) C) 0D 0-4 000 In 0 0 0- 00030 00000 蓐 M40) 1 Co W- Inco COW(D’ CO I CIDr CO r-Cr--- 0 pC-- pD (-pW r--r.-ow0 -4) ow ow 0000 COCOCO

Prime Contract Awards Alphabetically by Contractor, State or Country, and Place. Part 15 (Roofmasters Inc, Texarkana, Texas - South Dakota School of Mines and Technology, Rapid City, South Dakota), FY1991

DTIC Science & Technology

1991-01-01

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Prime Contract Awards Alphabetically by Contractor, by State or Country, and Place, FY 85. Part 13 (Mabco Prefabricated Bldg -Middletown Leather Co In).

DTIC Science & Technology

1985-01-01

04 C4 I4 C4I CNN NNN M.4f * N N N -4 -I .4 II.4NN *>-I w- C .40 C t In I, 0 I 1IC w040000oN 0 C4 . I CL 0. 0CZ in WI I )M nMI nIinn 00 CO(-ic.) I enC ...m I1 cNNL N ENC ’ 00 N N) N4 0(n MCI I C) 4 I -000r4 0 *.-0.- N~0 COJ cm mOi cl j C4 CMcj I ~ C)N NN 4~ Il N-.I-0I- 54-0 4 IU-4 1.I 4.I (I 4N - I ca c...40o 3X0 EN ENC , 3N 0 o-4 I-- EN" 0-4 1-400 MI 4 MO m)-I No 0 4- 0) (0 40 co In (o aU’Do Ml) 0 0 00 -4 -4 0 0 0 0 0 0 0 0 440)t M4 I n In In Ln -f 4 U

The Measurement of Motivational Style: A Format Modification.

DTIC Science & Technology

1983-03-01

Walter W . Tornow ...Statistics, 1976, 1, 113-125. Landy, F. J. and Becker, W . Adaptive Motivation Theory: Annual Report. Arlington: Office of Naval Research, 1981 Locke, E...C4’ ca C1 -4 0 01 V C4 C4 C4) C") 14 000 bo Cl -It ON 0 r’A -4 1-4 C0 C0 aN m’ C𔃾 (4 (4 ) -4 4 cn a) 0 co W ) U) :l r- L(4 0 m" (’Y) 0 -4-4 ON m" -4

Evaluation of US Air Force Survival/Armor Vest in US Army OH-58 Helicopters

DTIC Science & Technology

1976-02-01

Camera D. EVALUATION RESULTS: In releasing the cyclic friction, figures 3 £ 4, the left top *.Ige -f the armor insert and carrier hit the pilot’s chits ...ow4 -4 40 N) .44 .4 T- ek N . f. f0 r- 0 4 0 %nf𔃾 1035 -4 m) ko OD 4 m , ~ N0 4 4 -4 r4 -4 + 4 % 9 1 9 1 , 1 9 9 9 at ’ 4 . 4 0 a 0 0 ’I + 9 C a 94 9

77 FR 3590 - Registration of Swap Dealers and Major Swap Participants; Correction

Federal Register 2010, 2011, 2012, 2013, 2014

2012-01-25

...--REGISTRATION Sec. 3.1 [Corrected] 0 2. On page 2626 in the left column, in Sec. 3.1 Definitions, in paragraph (f), ``4s(e), 4s(f), 4s(h), 4s(i), 4s(j), 4s(k) or 4s(l) of the Act.'' is corrected to read ``4s(e), 4s(f), 4s(g), 4s(h), 4s(i), 4s(j), 4s(k) or 4s(l) of the Act.'' PART 23--[CORRECTED] 0 3. On page...

Descriptive Summaries for Program Elements of the Research, Development, Test and Evaluation, Army Program FY 1981. Volume I.

DTIC Science & Technology

1980-01-01

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Prime Contract Awards by State or Country, Place and Contractor. Part 12 (Pelham Manor, New York - New Knoxville, Ohio), FY1991

DTIC Science & Technology

1991-01-01

ON 3S NOWo 0. 4o 1- 0: CI (n< .4444NN --- 11.1 IS I ON4 If =0 w 0 4 40 I-40 0 20 .J00000 4 1 it I ON4 If 11.5 1- 0 1-- r IN 00 10 "-4< -14 44 0 0 .1...4 S -4--4 -4-4 -4 -4 -4 Nli-4NNMC1 * 0.4 a :2Z 2 m =z 2 Z=ZZZZ2 2 2ZZz a ( 347 ) U 4444 < 4 0 0040000000 w ɘɜ a ON C4 0000CD00 00W<M 0000a400 c0 0 2

Prime Contract Awards by State or Country, Place and Contractor. Part 1 (Addison, Alabama - Mountain Pine, Arkansas), FY1991

DTIC Science & Technology

1991-01-01

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A Comparison of the Meal, Ready-to-Eat, Ration, Cold Weather, and Ration, Lightweight Nutrient Intakes during Moderate Altitude Cold Weather Field Training Operations

DTIC Science & Technology

1988-11-01

SCE 107 1/4 1/2 3/4 1 2 CHICKEN A LA KING 176 1/4 1/2 3/4 1 2 BEEF STEW 113 1/4 1/2 3/4 1 2 HAM SLICE 105 1/4 1/2 3/4 1 2 MEATBALLS W/RICE 109 1/4 1/2...KING 176 1/4 1/2 3/4 1 2 BEEF STEW 113 1/4 1/2 3/4 1 2 HAM SLICE 105 1/4 1/2 3/4 1 2 MEATBALLS W/RICE 109 1/4 1/2 3/4 1 2 TUNA W/NOODLES 111 1/4 1/2 3

SIMTBED: A Graphical Test Bed for Analyzing and Reporting the Results of a Statistical Simulation Experiment.

DTIC Science & Technology

1983-09-01

Hlc i-4.-I "m uw t4 4 did) iJ t-4 my i 04il *a 4 2 04 W dc"- W" 00m U) m ) 0U) .2 wp. 0 13 asH JcI 0- d Era1O E-4.344C 2h 1-4 Er W co )14 m 4 0 CD WI2...4 W3-~- > C-0 *1- Me ft %- % W go 0% 4 % % C4 M *0*. E- w = V I~eW= = N E- =E ( 1.4 F-4 -* in Wf 11-.4 P 4U 1b.-4 E- n r1 ,o E4 in~ 131 -.4 IE in fl

Complete genomic sequences for hepatitis C virus subtypes 4b, 4c, 4d, 4g, 4k, 4l, 4m, 4n, 4o, 4p, 4q, 4r and 4t.

PubMed

Li, Chunhua; Lu, Ling; Wu, Xianghong; Wang, Chuanxi; Bennett, Phil; Lu, Teng; Murphy, Donald

2009-08-01

In this study, we characterized the full-length genomic sequences of 13 distinct hepatitis C virus (HCV) genotype 4 isolates/subtypes: QC264/4b, QC381/4c, QC382/4d, QC193/4g, QC383/4k, QC274/4l, QC249/4m, QC97/4n, QC93/4o, QC139/4p, QC262/4q, QC384/4r and QC155/4t. These were amplified, using RT-PCR, from the sera of patients now residing in Canada, 11 of which were African immigrants. The resulting genomes varied between 9421 and 9475 nt in length and each contains a single ORF of 9018-9069 nt. The sequences showed nucleotide similarities of 77.3-84.3 % in comparison with subtypes 4a (GenBank accession no. Y11604) and 4f (EF589160) and 70.6-72.8 % in comparison with genotype 1 (M62321/1a, M58335/1b, D14853/1c, and 1?/AJ851228) reference sequences. These similarities were often higher than those currently defined by HCV classification criteria for subtype (75.0-80.0 %) and genotype (67.0-70.0 %) division, respectively. Further analyses of the complete and partial E1 and partial NS5B sequences confirmed these 13 'provisionally assigned subtypes'.

Algorithm Development of a Telephone Signal Conditioner for the Wideband Integrated Network.

DTIC Science & Technology

1981-12-31

Fig. 25c presents the smoothI I ~~~- -. !... " -.... . . 89 -4 C 0 4.) -41 41 04 4) 4.) 04 r4 90 ., 0 .4) 4J 4.) > :$- 91 4-4 44 󈧭 4-4 󈧰J 44 04 N &Q...Channel Estimation May 25, 1979 4. John D. Markel, Steven B. Davis, and Ted Applebaum A Methodology for Studying Telephone Amplitude Distortion Effects

Annual Historical Review.

DTIC Science & Technology

1987-01-01

8217. ’. .4,. .. *4*’. 5.4* 4 4.. .4- *44 =1. 44* 4 .4 %SS 4- MAJOR GENERAL FRED HISSONG, JR. Commanding General US Army Armament, Munitions and Chemical...Command 4, 44 44. 3 4’ ~ 4~\\S~4~5........................ . . - AMCCOM Deputy Commanding Generals vii. % % TABLE OF CONTENTS Chapter p% i! COMMAND...Handling for Brake and Clutch Repair V 54 Steam Cleaners V 54 Tool Improvement Program Suggestions V 54-. Test Stand Automotive Generator , Alternator

Prime Contract Awards Alphabetically by Contractor, by State or Country, and Place, FY 88. Part 3. (Bakers Constr. Co., Inc.-Burns Lumber Co., Inc.)

DTIC Science & Technology

1988-01-01

00000 00000000 uI Wo m0 1 00000000004. "m0.-.4- 4~. - I WOO0 I *-4-4--4--4* -4O r- () )Mcc4-44 cc W CO ww wwww www w I4 L 0 -1 1 r- , fr r- - - w , f- r...34 NNNC0 N N -4 00 w 0 N4 4c1 Woe) I (0W -i - WWW V t’- N In 0 In (0 In CL I WOMI 1 -𔃾 4 M𔄁CI) M C C’ n (0 M" -4 (𔄁 .0 ’WON 0 444444 44400! 4 o cn...10)00 CN go* O N 00N 00(0 00(0 V N 00W 001- 0’)0 f00 10000t 0N WWW OWY -4 e-4 -4W -4 m 0 0 l D-4 -0 C-10 ON 4WC r-’I i-xm I I m c .-0 .-4 N -4/ rn

Prime Contract Awards Alphabetically by Contractor, State or Country, and Place. Part 12 (McFadden Jimmy, Portugal - NCR Japan LTD, Japan), FY1991

DTIC Science & Technology

1991-01-01

a .- 3 30 3030 300 3cm 3.4 30 3-00< 3 0. ataa0.4 II ow 4(:0( c0 4 40 100 4N4 40 a 0 40)0 4o-M00 doU 0.4 Nc o WO g aW0 cca Q0 .) adO U0 0 o c - (L...Go05o- 0 0 -4 1- ,000 I.U0 co 000 U cc- 100 U a. U L I ON U -4 .4 -.4 L.4..4 -4 .. 444- -~..4- 444 m4 o ’W’ I :00 4 cc00 -1.4I 000C )> .4 00 000000000...1900 0 1LLLS.*.O IUIiL.UjO 0 0 0 0 we *_ c. U i z0~ EiLS-nj ..JJi 1I I -3Ii 1 I I1 0 ME iC1-4 W U0 WMCI-4 NO 0 0 a Ia N 1 00-4 N 7-00 ado 5* 100 W0O

Alpha List of Prime Contract Awards. Oct 91 - Sep 92. FY 92. (Mill Distributors Inc - North Bay Contracting)

DTIC Science & Technology

1993-01-01

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Prime Contract Awards Alphabetically by Contractor, by State or Country, and Place. Part 3. (Beachy Lumber Co.-Campanova, Richard MD)

DTIC Science & Technology

1989-01-01

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All Prime Contract Awards by State or Country, Place and Contractor. Part 5. (Adobe, Colorado-Washington, DC)

DTIC Science & Technology

1989-01-01

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Prime Contract Awards Alphabetically by Contractor, by State or Country, and Place, FY 85. Part 16 (Pilot Electric Co - Reyex Corporation).

DTIC Science & Technology

1985-01-01

1. - > m 4 1, - I.- i ILI NIB 10O- *W 440 J -4 41 0 Me 0- 0 a0-0j 0-4 1’-1 M- to mI v 0) 0. U 0 0. 3 -4 0 -4 3-) cl 04)14)0 I cc m41 04N 000 .4 04 . 4...0 4 00-C4 4" -N 0 4) 004 ’-4 0 404 (04N 04 NI 0 n0 cacao 0In 0 041 0 In 0 00 000-1 >00 -iN 0000 vot, I Goc )I O- n 0< 000 0C O OCIC 0 0 *~ I0. 4𔃺...W-4C’ w6-- de 0( I 4 0) 0- 0-4 CL-4 04L" 04 00 -4 CL 4 (5 C N44 C 4 4 4 4026 I --= I I 204 *L I If I -402 02) M n .1 n an .-- 4 mn a n Inlf InLnnman

Dynamics of the Eye and Head when Switching Visual Attention Between Two Tasks

DTIC Science & Technology

1976-10-01

EC R T CL SS47AT3 ODIIO THI PAG NOVe. 68I ateE n l ss f e unclassified................. ’i., U UITY CLASSIFICATION OF THIS PAGC(IWm &We D n task...identifi- cation for their processing task (Bartz, 1962; Neisser , 1964; Teichner and Krebs, 1974). Robinson, Koth and Ringenbach (1976) varied the...start of the trial. $4 V Ul 0 4 U 4J 0 r- 4 ) *.-4 4) 4 10 C4J 04. A 4 0 )4. U f E0 0 II 𔃾. 0 41 rI030 ’no,1m Im or $4 -4 $4 Id4; tr ’, C,-4$4 4 I ir

Navy Command Control and Communications System: Layered Analytic Model.

DTIC Science & Technology

1981-09-27

of these persons can be prescribed in terms of the model. Thus the Fleet, CINC, OTC, CO, TAO , Operations Officer, Air Intercept Controller, Supply...04 o-r 4 400 0n 0.14 to r WQ I 0 tvm 9 u 3t~ *w 0)o) 04 P40U u w) 4) 4- 0 4- -4()04) .4.) 41 41 41 0 r 0 4 > 4 4)(L 4 L tw 0 M 4 4J 04 $4 (a-3 4)J 40

Prime Contract Awards by State or Country, Place and Contractor. Part 2 (Murfreesboro, Arkansas - Livermore, California), FY1991

DTIC Science & Technology

1991-01-01

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29 CFR Appendix A to Subpart S of... - Decompression Tables

Code of Federal Regulations, 2011 CFR

2011-07-01

... uniform rate from 4 pounds to 0-pound gage over a period of 40 minutes. Rate—0.10 pound per minute or 10.../pound Total time decompress minutes 14 1/2 1 14 4 2 0.20 6 2 4 0 4 1.00 6 1 1 14 4 2 0.20 6 2 4 0 4 1.00 6 11/2 1 14 4 2 0.20 6 2 4 0 4 1.00 6 2 1 14 4 2 0.20 6 2 4 0 4 1.00 6 3 1 14 4 2 0.20 6 2 4 0 4 1...

Word Frequency Analysis. MOS: 13E. Skill Levels 1 & 2.

DTIC Science & Technology

1981-05-01

MrTA L 1o0 METFR 71 mm RS 11 WFT4I3l 4 M I I’$a 2 Mr. j.PHI I MIf, -5 111’O"𔃾lr I MIDI 1 mIppfl NT 1 .4 Ir14 2 MIKE ’ MIL. I Mll -1 -J41078 I "it -L...4 VI SU ALLY ~ 4 VOLTS 4 VflIJ4 4 FV 4 WAv 4 WE 4 Wf IGF 4V’ 4 alIP4 41F3 AP--; 3 AT 4 ANP 4 IPF Ar~flO/fnr 3 ACFIIKAC V 3 Iht󈧭EYE 3 AC TIVI TY

Trans-tail regulation of MLL4-catalyzed H3K4 methylation by H4R3 symmetric dimethylation is mediated by a tandem PHD of MLL4

PubMed Central

Dhar, Shilpa S.; Lee, Sung-Hun; Kan, Pu-Yeh; Voigt, Philipp; Ma, Li; Shi, Xiaobing; Reinberg, Danny; Lee, Min Gyu

2012-01-01

Mixed-lineage leukemia 4 (MLL4; also called MLL2 and ALR) enzymatically generates trimethylated histone H3 Lys 4 (H3K4me3), a hallmark of gene activation. However, how MLL4-deposited H3K4me3 interplays with other histone marks in epigenetic processes remains largely unknown. Here, we show that MLL4 plays an essential role in differentiating NT2/D1 stem cells by activating differentiation-specific genes. A tandem plant homeodomain (PHD4–6) of MLL4 recognizes unmethylated or asymmetrically dimethylated histone H4 Arg 3 (H4R3me0 or H4R3me2a) and is required for MLL4's nucleosomal methyltransferase activity and MLL4-mediated differentiation. Kabuki syndrome mutations in PHD4–6 reduce PHD4–6's binding ability and MLL4's catalytic activity. PHD4–6's binding strength is inhibited by H4R3 symmetric dimethylation (H4R3me2s), a gene-repressive mark. The protein arginine methyltransferase 7 (PRMT7), but not PRMT5, represses MLL4 target genes by up-regulating H4R3me2s levels and antagonizes MLL4-mediated differentiation. Consistently, PRMT7 knockdown increases MLL4-catalyzed H3K4me3 levels. During differentiation, decreased H4R3me2s levels are associated with increased H3K4me3 levels at a cohort of genes, including many HOXA and HOXB genes. These findings indicate that the trans-tail inhibition of MLL4-generated H3K4me3 by PRMT7-regulated H4R3me2s may result from H4R3me2s's interference with PHD4–6's binding activity and is a novel epigenetic mechanism that underlies opposing effects of MLL4 and PRMT7 on cellular differentiation. PMID:23249737

Trans-tail regulation of MLL4-catalyzed H3K4 methylation by H4R3 symmetric dimethylation is mediated by a tandem PHD of MLL4.

PubMed

Dhar, Shilpa S; Lee, Sung-Hun; Kan, Pu-Yeh; Voigt, Philipp; Ma, Li; Shi, Xiaobing; Reinberg, Danny; Lee, Min Gyu

2012-12-15

Mixed-lineage leukemia 4 (MLL4; also called MLL2 and ALR) enzymatically generates trimethylated histone H3 Lys 4 (H3K4me3), a hallmark of gene activation. However, how MLL4-deposited H3K4me3 interplays with other histone marks in epigenetic processes remains largely unknown. Here, we show that MLL4 plays an essential role in differentiating NT2/D1 stem cells by activating differentiation-specific genes. A tandem plant homeodomain (PHD(4-6)) of MLL4 recognizes unmethylated or asymmetrically dimethylated histone H4 Arg 3 (H4R3me0 or H4R3me2a) and is required for MLL4's nucleosomal methyltransferase activity and MLL4-mediated differentiation. Kabuki syndrome mutations in PHD(4-6) reduce PHD(4-6)'s binding ability and MLL4's catalytic activity. PHD(4-6)'s binding strength is inhibited by H4R3 symmetric dimethylation (H4R3me2s), a gene-repressive mark. The protein arginine methyltransferase 7 (PRMT7), but not PRMT5, represses MLL4 target genes by up-regulating H4R3me2s levels and antagonizes MLL4-mediated differentiation. Consistently, PRMT7 knockdown increases MLL4-catalyzed H3K4me3 levels. During differentiation, decreased H4R3me2s levels are associated with increased H3K4me3 levels at a cohort of genes, including many HOXA and HOXB genes. These findings indicate that the trans-tail inhibition of MLL4-generated H3K4me3 by PRMT7-regulated H4R3me2s may result from H4R3me2s's interference with PHD(4-6)'s binding activity and is a novel epigenetic mechanism that underlies opposing effects of MLL4 and PRMT7 on cellular differentiation.

All Prime Contract Awards by State or Country, Place, and Contractor, FY 87. Part 19. Abilene, Texas-Winooski, Vermont.

DTIC Science & Technology

1987-01-01

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AFOSR (Air Force Office of Scientific Research) Technical Report Summaries.

DTIC Science & Technology

1985-12-01

4 uu -~ - c a IL ~ cm a.Cu m in’ em> 0 4.- In 0- ’-. 84 * . m.aof7ai x-’ 4e lox C mui EL > CL >’ W (A 4S .UC Z ~L wn 0a 4- 40 MA- a (aIm-lA kLu P4...U > 4. v > 0; i Csc 0 4. .0 Co L Zm.- 0L W-4 - 43 (A in - om p4’c a :Lia ; n J o 30win 4- ! ~ de ~ 0’~ - 0 - 41 CA. L 1-s- z44 1-. 44U . 0 L4 0 4 - L...t I - I.- o 16 00 0 0 00 C~0 0 0 lz 4 U 4 U 4 4 U 4 404 U B 8 Q 00 L S 0). de U sCC C4 . A 00 a IA - I-- C40 - U LO 0 C IF -u LL IA Sgo .0 z-4- -4

Metal-Borohydride-Modified Zr(BH4 )4 ⋅8 NH3 : Low-Temperature Dehydrogenation Yielding Highly Pure Hydrogen.

PubMed

Huang, Jianmei; Ouyang, Liuzhang; Gu, Qinfen; Yu, Xuebin; Zhu, Min

2015-10-12

Due to its high hydrogen density (14.8 wt %) and low dehydrogenation peak temperature (130 °C), Zr(BH4 )4 ⋅8 NH3 is considered to be one of the most promising hydrogen-storage materials. To further decrease its dehydrogenation temperature and suppress its ammonia release, a strategy of introducing LiBH4 and Mg(BH4 )2 was applied to this system. Zr(BH4 )4 ⋅8 NH3 -4 LiBH4 and Zr(BH4 )4 ⋅8 NH3 -2 Mg(BH4 )2 composites showed main dehydrogenation peaks centered at 81 and 106 °C as well as high hydrogen purities of 99.3 and 99.8 mol % H2 , respectively. Isothermal measurements showed that 6.6 wt % (within 60 min) and 5.5 wt % (within 360 min) of hydrogen were released at 100 °C from Zr(BH4 )4 ⋅8 NH3 -4 LiBH4 and Zr(BH4 )4 ⋅8 NH3 -2 Mg(BH4 )2 , respectively. The lower dehydrogenation temperatures and improved hydrogen purities could be attributed to the formation of the diammoniate of diborane for Zr(BH4 )4 ⋅8 NH3 -4 LiBH4 , and the partial transfer of NH3 groups from Zr(BH4 )4 ⋅8 NH3 to Mg(BH4 )2 for Zr(BH4 )4 ⋅8 NH3 -2 Mg(BH4 )2 , which result in balanced numbers of BH4 and NH3 groups and a more active H(δ+) ⋅⋅⋅(-δ) H interaction. These advanced dehydrogenation properties make these two composites promising candidates as hydrogen-storage materials. © 2015 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

All Prime Contract Awards by State or Country, Place and Contractor. Part 3. (Lemon Grove, California-San Bruno, California)

DTIC Science & Technology

1989-01-01

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All Prime Contract Awards by State or Country, Place, and Contractor, FY 88. Part 13. (Akron, New York-Yorktown Heights, New York).

DTIC Science & Technology

1988-01-01

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Downstream Stockton Assessments

DTIC Science & Technology

1992-01-01

marilandica), scarlet oak (Q. coccinea) and mockernut hickory (Carya tomentosa) with a lowbush blueberry (Vaccinium vacillans) understory predominating on...821740 a’~ .. io . N C6 ~ 6 1 4 -4 =, 40 a 6 ’a 0 m~’ u’ 44 u𔃽 Au’’ 44444uj6 fl. 0 M~ US -.0 ŕ U. A’.’ 4 ,0 Z.4 0’ to x -4 a#. ~ 4 v r 0 4Z 4C.4 r .. 0...a a j 0. 0a 4.. 0). a4 >? 0-’d’ ~ .* C£? 3. ~ 0 v 4?C 0 4 l.4? -004 -0 IO - a’A.4* 0 C 0 u . we 4C, sk 4. 4.C?0 * ’ 0 0 04. * 0 to 6104 u 04. 0.1. Aa

Design and Analysis of Composite Roadwheels for LVTP7 and M113A1

DTIC Science & Technology

1984-08-01

mid radius of the wheel. As this laminate turns the corner into the rim it becomes mixed with layers in the hoop direction until, at the outer...Owens Corning Fiberglas, Advanced Composites, Marketing Section, Fiberglas Tower, Toledo, OH 43659 1 ATTN: Larry Dickson Goodyear Aerospace...4 3 -« 4*4 3*4 4 kfc . 4 4 kk-4k0« O • 4 I 4 •£ *i >. 4 3 i’H)*ssK£Hire •>k fi««*004-40 k M 4 0 • ft-H 4 C -4 b 4 44

Nutrient Intakes and Work Performance of Soldiers during Seven Days of Exercise at 7,200 Feet Ready-to-Eat Ration

DTIC Science & Technology

1986-09-19

100.000 *4 • D " ",4.. .4.’-’ FrteiuEncy of M1aE Fouds Consumed CLASS=khJlTS FCOOD NAM~E FOOD FREQUENCY CUM? FaL1 £EjcENlI CUM PER~CENT APPLESAUCE ...4 1/2 3/4 all JELLY 1/4 1/2 3/4 all PEANUT BUTTER 1/4 1/2 3/4 all FRUIT APPLESAUCE 1/4 1/2 3/4 all MIXED FRUITS 1/4 1/2 3/4 all PEACHES 1/4 1/2 3/4

Subcontracting Opportunities with DoD Major Prime Contractors

DTIC Science & Technology

1991-01-01

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Department of Defense Prime Contract Awards in Labor Surplus Areas. Fiscal Year 1989

DTIC Science & Technology

1989-01-01

S0 . 0 L. 4 * Q .0 44C 04A 0 . o L.s LO 2 A L.O : O I *a-C .4 45A 4 V)- C0 LO a- U L. 00 PA08 0 4, LO . . 1 . -4 6- me 4p L .LU L8 L L. m. 0~ C. CU 0...00 4A U- eg-0.a.-I to C L 0 4 i 10 L . -L L 4 L. L3U * ~ C L . 0 (I 0 * -W COL too iL 5.4 -4- 00 0 -4 L. 40 -im0 l ൒-0 1 % A 0fmUS 04 440c0c& onmS...4A 4 La Xm. 0 C 30 C 4. CmU %.. L.L *L A"W 0 00e am me 4..E1 4.44 L.m mL L. 41U..Cu) W4..S 4 . L. AC o % I* . a*B am L4A C- 1 =L -4j O&US 44 L. 0~* -4 0

Prime Contract Awards by State or Country, Place and Contractor. Part 11 (Gibbsboro Air Force Station, New Jersey - Peekskill, New York), FY1991

DTIC Science & Technology

1991-01-01

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Prime Contract Awards Alphabetically by Contractor, by State or Country, and Place, Fiscal Year 1987. Part 10. Input S R L-Kodensha Company, Ltd.

DTIC Science & Technology

1987-01-01

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Software Engineering Principles.

DTIC Science & Technology

1980-07-01

IC’ a It, It, Io It, It, o H 10 ~ Iro I0 E10 10 1 1 0 I 11. 1. 1. 10 1 0 1 0 1 c6 of a" I a f C f I 1 11 1 16 D , O f o 4 o I c1 w t I A, t I m 1 1 ca ...V. 4 4 4 I lbl. b 1 0 40 4 0 1 4 43c 4 40 ’ 10 40 4 I 10 4 4 1 4 4 40 Ic 1 011 1 If 0 . in44 3 4 4 3 4 4 I Io3 .4 4i I InI I I I 4 3 I CA I 4 I 4 3 I4...I 60 60 10 601 60. 6I I0 60 1~ 1 W 1 W 601 I3 Er- 6I 614 664;n3 6 W l. 60 l. 6 1 3 6 64 lb 46 lb l lb 6 M it I CA 0 6 lb. lbaa 1 0 r5 g m I . n lb lm

All Prime Contract Awards by State or Country, Place, and Contractor, FY 85. Part 6 (Alachua, Florida - Winder, Georgia).

DTIC Science & Technology

1985-01-01

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Prime Contract Awards by State or Country, Place and Contractor. Part 4 (Salinas, California - Lompoc Valley, California), FY1991

DTIC Science & Technology

1991-01-01

1 L)if I M4’) 100 < of ICO 1a" 0..( crI of ) " i X I- H 011 WCN I(A z EfmE 1 3 I4 o 0f mIi I mcON I’ ~0L4C0L0O)0AIC)0’N𔃾LN-C.4)-4CCLC)4)00~C ofI z...00n Inn~~U~f Gn)fUU U o LU L) NLL a 00 4N N m oo---444444--.4- COO- - -4 4 4 4- - - - 0.o0 04o- 4M 100 NO moo0 0 j IX N11- 10000c N 4 0000 4 -ON -0)000...2j O il to N I ciI- $._ I 1-4_ J ZN 100 N13 U 11 wo x IN4 0 Na (0, 21 - 4co()0r na >c4r-I 0- o ni 7 .- - 4ɘ . D 0 0 $_r 044 81 CN NfC)0 Y o - * 4r 0

Geographic List of Prime Contract Awards. Oct 91 - Sep 92. FY92. (Germany - Classified Location Foreign)

DTIC Science & Technology

1993-01-01

n C . 0 4 - ’ ’ U-- 5 U U U0 U U U 0 0 0 0 0)00 0 S.W E 0 M m 01 &- cC-4 aC ad a 0C 4 4 4 (A-0 40 0 E - 0 CL 0 o 0 c - V L0 Z r o 0e V! . - & 4 4 ,1 4...00 Q0 M000000420000 .1 U w 4 000-s 4 11 4N <Cio N < 5 \\jOCOa-1 -1-4i(71N " ൒O 4C’ 4(1.1 4000000000><><>C>c M4 100-4 4f 0))) 0) 0) ) 0) 0) O () ()0...no04w is of 1 004w I LL) to 14L 001*0 4’ <<Cc� 44 4 0040)4 <<<Cc44444 44 4 44 o0- " 5 :: J-- -.J - JJJJ-j-J -J.J--Ii- . ft U-4 M 0 :: XXZX of 0

All Prime Contract Awards by State or Country, Place, and Contractor. Part 23 (Iceland-TRW INC Classified Location)

DTIC Science & Technology

1990-01-01

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A Set of Organizational-Climate Measures: Internal Consistency, Factor Structure, and Predictive Power.

DTIC Science & Technology

1983-10-01

E 5-- 4 5 5 5 5 5- * r 4.)Ce. 41 V V "a V V (Ai NC N NC C NCMC C NCc xC N C LUJ C ) 0 D 0 M Lc 0~ N flYN Lfl to 4/)44 (Y, LL. 41 4 4-W 0L t to 4,ia 4...tUo ) )4 ) C 4- 0 L. 1 0 4-- Li CA 0 C =4 apL 0 r -W wc -1 4- 4C- U+ d)1 4-4 C - L- U) E (1) CD (1) (1)- t0 0a L- -i CL LA- fC--A W3 07: - > " TO -- ~ * A...cninr-O 0 = (A .0 >n r -.4 0 0 i L 00 0 00 4-) 4. - 4 ,- E 0 .( CZ CJz V r CL 00

Word Frequency Analysis. MOS: 62J. Skill Levels 1 & 2.

DTIC Science & Technology

1981-05-01

WCRDI COUNT2 W OR u, CO UIT 3 WORD 3 COUNT’. kCRD4 I CELL 9 CLNTER I CERERLINE t CENTRALLY 2 C [JTP I FGAL 2 CZRT..IN I CESSIVE 46 LFI’ 14 C H%1% ~ 4...4 .4* 4 AD ,G4 ANGLI 4 fC S 0A 4 r. 5 54b d204 4 BE- J 4OCK4 ECAGNE 4 TTA .(.KFTS 4 B𔃻E.KER 4 44 CC!’PPCT 4 13FL*.~If 4 CCLC CTwV7CCC~L< EL4 CO 4 CE...t CI RE I CARTcUL I CAR7~ I 3 CARRY I CAL 7I C!! 11 E t C., TFPS I CA~TCH I C4TEO I co usIN Kr I CL TC1 I CELL 1CTNlERL!NEz I ’ENI P.LIY Ic3VEI

Fenretinide metabolism in humans and mice: utilizing pharmacological modulation of its metabolic pathway to increase systemic exposure

PubMed Central

Cooper, Jason P; Hwang, Kyunghwa; Singh, Hardeep; Wang, Dong; Reynolds, C Patrick; Curley, Robert W; Williams, Simon C; Maurer, Barry J; Kang, Min H

2011-01-01

BACKGROUND AND PURPOSE High plasma levels of fenretinide [N-(4-hydroxyphenyl)retinamide (4-HPR)] were associated with improved outcome in a phase II clinical trial. Low bioavailability of 4-HPR has been limiting its therapeutic applications. This study characterized metabolism of 4-HPR in humans and mice, and to explore the effects of ketoconazole, an inhibitor of CYP3A4, as a modulator to increase 4-HPR plasma levels in mice and to increase the low bioavailability of 4-HPR. EXPERIMENTAL APPROACH 4-HPR metabolites were identified by mass spectrometric analysis and levels of 4-HPR and its metabolites [N-(4-methoxyphenyl)retinamide (4-MPR) and 4-oxo-N-(4-hydroxyphenyl)retinamide (4-oxo-4-HPR)] were quantified by high-performance liquid chromatography (HPLC). Kinetic analysis of enzyme activities and the effects of enzyme inhibitors were performed in pooled human and pooled mouse liver microsomes, and in human cytochrome P450 (CYP) 3A4 isoenzyme microsomes. In vivo metabolism of 4-HPR was inhibited in mice. KEY RESULTS Six 4-HPR metabolites were identified in the plasma of patients and mice. 4-HPR was oxidized to 4-oxo-4-HPR, at least in part via human CYP3A4. The CYP3A4 inhibitor ketoconazole significantly reduced 4-oxo-4-HPR formation in both human and mouse liver microsomes. In two strains of mice, co-administration of ketoconazole with 4-HPR in vivo significantly increased 4-HPR plasma concentrations by > twofold over 4-HPR alone and also increased 4-oxo-4-HPR levels. CONCLUSIONS AND IMPLICATIONS Mice may serve as an in vivo model of human 4-HPR pharmacokinetics. In vivo data suggest that the co-administration of ketoconazole at normal clinical doses with 4-HPR may increase systemic exposure to 4-HPR in humans. PMID:21391977

Donor-Derived Regulatory Dendritic Cell Infusion Maintains Donor-Reactive CD4+CTLA4hi T Cells in Non-Human Primate Renal Allograft Recipients Treated with CD28 Co-Stimulation Blockade.

PubMed

Ezzelarab, Mohamed B; Lu, Lien; Shufesky, William F; Morelli, Adrian E; Thomson, Angus W

2018-01-01

Donor-derived regulatory dendritic cell (DCreg) infusion before transplantation, significantly prolongs renal allograft survival in non-human primates. This is associated with enhanced expression of the immunoregulatory molecules cytotoxic T-lymphocyte-associated antigen (Ag) 4 (CTLA4) and programmed cell death protein 1 (PD1) by host donor-reactive T cells. In rodents and humans, CD28 co-stimulatory pathway blockade with the fusion protein CTLA4:Ig (CTLA4Ig) is associated with reduced differentiation and development of regulatory T cells (Treg). We hypothesized that upregulation of CTLA4 by donor-reactive CD4 + T cells in DCreg-infused recipients treated with CTLA4Ig, might be associated with higher incidences of donor-reactive CD4 + T cells with a Treg phenotype. In normal rhesus monkeys, allo-stimulated CD4 + CTLA4 hi , but not CD4 + CTLA4 med/lo T cells exhibited a regulatory phenotype, irrespective of PD1 expression. CTLA4Ig significantly reduced the incidence of CD4 + CTLA4 hi , but not CD4 + CTLA4 med/lo T cells following allo-stimulation, associated with a significant reduction in the CD4 + CTLA4 hi /CD4 + CTLA4 med/lo T cell ratio. In CTLA4Ig-treated renal allograft recipient monkeys, there was a marked reduction in circulating donor-reactive CD4 + CTLA4 hi T cells. In contrast, in CTLA4Ig-treated monkeys with DCreg infusion, no such reduction was observed. In parallel, the donor-reactive CD4 + CTLA4 hi /CD4 + CTLA4 med/lo T cell ratio was reduced significantly in graft recipients without DCreg infusion, but increased in those given DCreg. These observations suggest that pre-transplant DCreg infusion promotes and maintains donor-reactive CD4 + CTLA4 hi T cells with a regulatory phenotype after transplantation, even in the presence of CD28 co-stimulation blockade.

Donor-Derived Regulatory Dendritic Cell Infusion Maintains Donor-Reactive CD4+CTLA4hi T Cells in Non-Human Primate Renal Allograft Recipients Treated with CD28 Co-Stimulation Blockade

PubMed Central

Ezzelarab, Mohamed B.; Lu, Lien; Shufesky, William F.; Morelli, Adrian E.; Thomson, Angus W.

2018-01-01

Donor-derived regulatory dendritic cell (DCreg) infusion before transplantation, significantly prolongs renal allograft survival in non-human primates. This is associated with enhanced expression of the immunoregulatory molecules cytotoxic T-lymphocyte-associated antigen (Ag) 4 (CTLA4) and programmed cell death protein 1 (PD1) by host donor-reactive T cells. In rodents and humans, CD28 co-stimulatory pathway blockade with the fusion protein CTLA4:Ig (CTLA4Ig) is associated with reduced differentiation and development of regulatory T cells (Treg). We hypothesized that upregulation of CTLA4 by donor-reactive CD4+ T cells in DCreg-infused recipients treated with CTLA4Ig, might be associated with higher incidences of donor-reactive CD4+ T cells with a Treg phenotype. In normal rhesus monkeys, allo-stimulated CD4+CTLA4hi, but not CD4+CTLA4med/lo T cells exhibited a regulatory phenotype, irrespective of PD1 expression. CTLA4Ig significantly reduced the incidence of CD4+CTLA4hi, but not CD4+CTLA4med/lo T cells following allo-stimulation, associated with a significant reduction in the CD4+CTLA4hi/CD4+CTLA4med/lo T cell ratio. In CTLA4Ig-treated renal allograft recipient monkeys, there was a marked reduction in circulating donor-reactive CD4+CTLA4hi T cells. In contrast, in CTLA4Ig-treated monkeys with DCreg infusion, no such reduction was observed. In parallel, the donor-reactive CD4+CTLA4hi/CD4+CTLA4med/lo T cell ratio was reduced significantly in graft recipients without DCreg infusion, but increased in those given DCreg. These observations suggest that pre-transplant DCreg infusion promotes and maintains donor-reactive CD4+CTLA4hi T cells with a regulatory phenotype after transplantation, even in the presence of CD28 co-stimulation blockade. PMID:29520267

Synthesis, spectral, and structural studies of porphyrins having sterically hindered [η(5)-CpCo(η(4)-C4Ph4)] cobalt sandwich units at the meso positions.

PubMed

Keshav, Karunesh; Kumar, Dheeraj; Elias, Anil J

2013-11-04

Synthesis, spectral, and structural studies of the first examples of porphyrins substituted at the meso positions with sterically hindered η(5)-CpCo(η(4)-C4Ph4) cobalt sandwich units are described. The novel dipyrromethane derived cobalt sandwich compound {η(5)-[(C4H4N)2CH]C5H4}Co(η(4)-C4Ph4) 1, as well as its parent aldehyde, η(5)-[C5H4(CHO)]Co(η(4)-C4Ph4), were used in the synthesis of porphyrins having one or two η(5)-CpCo(η(4)-C4Ph4) groups at their meso positions. 1,9-Diformyldipyrromethane derived η(5)-CpCo(η(4)-C4Ph4) 2 was synthesized using dipyrromethane 1 under Vilsmeier conditions. A reaction of 2 with unsubstituted dipyrromethane under basic conditions in the presence of Pd(C6H5CN)2Cl2 yielded an A-type palladium coordinated porphyrin 3 [where A = η(5)-CpCo(η(4)-C4Ph4)]. A similar reaction of 2 with meso aryl and ferrocenyl-substituted dipyrromethanes yielded trans-AB type palladium coordinated porphyrins 4-6 [where A = η(5)-CpCo(η(4)-C4Ph4) and B = 4-tert-butylphenyl 4, ferrocenyl 5, and pentafluorophenyl 6]. Reactions of 2 with 5-ferrocenyl dipyrromethane under the same reaction conditions in the presence of Ni(acac)2 and Zn(OAc)2 gave the trimetallic nickel(II) and zinc(II) complexed trans-AB type porphyrins 7 and 8 having both cobalt and iron sandwich units at the meso positions. Crystal structure of the Pd(II) porphyrin 5 and nickel(II) porphyrin 7 showed nonplanar structures having distinct ruffle type distortion of the porphyrin ring. Demetalation of the zinc(II) trans-AB type porphyrin 8 in the presence of trifluoroacetic acid gave the metal free base porphyrin 9. Reactions of the cobalt sandwich aldehyde [(η(5)-C5H4(CHO)]Co(η(4)-C4Ph4) with sterically hindered dipyrromethane derivatives under acid-catalyzed condensation reactions gave trans-A2B2 type porphyrins [where A = η(5)-CpCo(η(4)-C4Ph4) and B = pentafluorophenyl, 10 mesityl 11]. In contrast, reactions of [η(5)-C5H4(CHO)]Co(η(4)-C4Ph4) with sterically unhindered meso-4-tert-butylphenyl dipyrromethane resulted in both AB3 12 and cis-A2B2 13 type porphyrins [where A = η(5)-CpCo(η(4)-C4Ph4) and B = (4-tert-butylphenyl] as a result of scrambling. The new porphyrin derivatives have been structurally characterized, and their spectral and electrochemical features were determined.

Synthesis, structure and properties of bimetallic sodium rare-earth (RE) borohydrides, NaRE(BH4)4, RE = Ce, Pr, Er or Gd.

PubMed

Payandeh GharibDoust, SeyedHosein; Ravnsbæk, Dorthe B; Černý, Radovan; Jensen, Torben R

2017-10-10

Formation, stability and properties of new metal borohydrides within RE(BH 4 ) 3 -NaBH 4 , RE = Ce, Pr, Er or Gd is investigated. Three new bimetallic sodium rare-earth borohydrides, NaCe(BH 4 ) 4 , NaPr(BH 4 ) 4 and NaEr(BH 4 ) 4 are formed based on an addition reaction between NaBH 4 and halide free rare-earth metal borohydrides RE(BH 4 ) 3 , RE = Ce, Pr, Er. All the new compounds crystallize in the orthorhombic crystal system. NaCe(BH 4 ) 4 has unit cell parameters of a = 6.8028(5), b = 17.5181(13), c = 7.2841(5) Å and space group Pbcn. NaPr(BH 4 ) 4 is isostructural to NaCe(BH 4 ) 4 with unit cell parameters of a = 6.7617(2), b = 17.4678(7), c = 7.2522(3) Å. NaEr(BH 4 ) 4 crystallizes in space group Cmcm with unit cell parameters of a = 8.5379(2), b = 12.1570(4), c = 9.1652(3) Å. The structural relationships, also to the known RE(BH 4 ) 3 , are discussed in detail and related to the stability and synthesis conditions. Heat treatment of NaBH 4 -Gd(BH 4 ) 3 mixture forms an unstable amorphous phase, which decomposes after one day at RT. NaCe(BH 4 ) 4 and NaPr(BH 4 ) 4 show reversible hydrogen storage capacity of 1.65 and 1.04 wt% in the fourth H 2 release, whereas that of NaEr(BH 4 ) 4 continuously decreases. This is mainly assigned to formation of metal hydrides and possibly slower formation of sodium borohydride. The dehydrogenated state clearly contains rare-earth metal borides, which stabilize boron in the dehydrogenated state.

Alpha List of Prime Contract Awards. Oct 91 - Sep 92. FY 92 (Avonix Corp - Branscome Henry S Inc)

DTIC Science & Technology

1993-01-01

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Enhancement of nitric oxide decomposition efficiency achieved with lanthanum-based perovskite-type catalyst.

PubMed

Pan, Kuan Lun; Chen, Mei Chung; Yu, Sheng Jen; Yan, Shaw Yi; Chang, Moo Been

2016-06-01

Direct decompositions of nitric oxide (NO) by La0.7Ce0.3SrNiO4, La0.4Ba0.4Ce0.2SrNiO4, and Pr0.4Ba0.4Ce0.2SrNiO4 are experimentally investigated, and the catalysts are tested with different operating parameters to evaluate their activities. Experimental results indicate that the physical and chemical properties of La0.7Ce0.3SrNiO4 are significantly improved by doping with Ba and partial substitution with Pr. NO decomposition efficiencies achieved with La0.4Ba0.4Ce0.2SrNiO4 and Pr0.4Ba0.4Ce0.2SrNiO4 are 32% and 68%, respectively, at 400 °C with He as carrier gas. As the temperature is increased to 600 °C, NO decomposition efficiencies achieved with La0.4Ba0.4Ce0.2SrNiO4 and Pr0.4Ba0.4Ce0.2SrNiO4, respectively, reach 100% with the inlet NO concentration of 1000 ppm while the space velocity is fixed at 8000 hr(-1). Effects of O2, H2O(g), and CO2 contents and space velocity on NO decomposition are also explored. The results indicate that NO decomposition efficiencies achieved with La0.4Ba0.4Ce0.2SrNiO4 and Pr0.4Ba0.4Ce0.2SrNiO4, respectively, are slightly reduced as space velocity is increased from 8000 to 20,000 hr(-1) at 500 °C. In addition, the activities of both catalysts (La0.4Ba0.4Ce0.2SrNiO4 and Pr0.4Ba0.4Ce0.2SrNiO4) for NO decomposition are slightly reduced in the presence of 5% O2, 5% CO2, or 5% H2O(g). For durability test, with the space velocity of 8000 hr(-1) and operating temperature of 600 °C, high N2 yield is maintained throughout the durability test of 60 hr, revealing the long-term stability of Pr0.4Ba0.4Ce0.2SrNiO4 for NO decomposition. Overall, Pr0.4Ba0.4Ce0.2SrNiO4 shows good catalytic activity for NO decomposition. Nitrous oxide (NO) not only causes adverse environmental effects such as acid rain, photochemical smog, and deterioration of visibility and water quality, but also harms human lungs and respiratory system. Pervoskite-type catalysts, including La0.7Ce0.3SrNiO4, La0.4Ba0.4Ce0.2SrNiO4, and Pr0.4Ba0.4Ce0.2SrNiO4, are applied for direct NO decomposition. The results show that NO decomposition can be enhanced as La0.7Ce0.3SrNiO4 is substituted with Ba and/or Pr. At 600 °C, NO decomposition efficiencies achieved with La0.4Ba0.4Ce0.2SrNiO4 and Pr0.4Ba0.4Ce0.2SrNiO4 reach 100%, demonstrating high activity and good potential for direct NO decomposition. Effects of O2, H2O(g), and CO2 contents on catalytic activities are also evaluated and discussed.

Prime Contract Awards Over $25,000 by Major System, Contractor and State, Fiscal Year 1987. Part 2. BSP-SMZ.

DTIC Science & Technology

1987-01-01

I - II t. AI OV444V4 W 4 V V 0)4 -4 44 -4 4 0 W 1 . 0W4 _4 m C.) 00IL OIL 00 1,0U 00 0r z I I ~~ I 4 ~ - I ...r- (4 𔃻 =4 V ) 4 I - 4 U) 6’’ 0 4 011 00.0 CL ... ( O 0.)O O( 4 O’ 0 Oil 0~0 )4 - 0 slO) w . ) - ’J1 4*£) CJ.’ ’ 4’C~’ Ax~ I ~0- WO- zI 0 1 00 C COO... I In11 I (D C,~~ f 0- I I II I I I oil III III IIIN lot III t5 I

Instrumentation for Detecting Hazardous Materials.

DTIC Science & Technology

1980-06-01

CATALOG NUMBER 1940-4)_ _ _ _ _ _ 4. TITLE (,.d Subtitle) _ JVE OF r , AL*3O.[OYE_ D .- / Final ; , .. P - 4^NSTRUtENTAT ION FOR DETECTING HAZARDOUS...CL a D- 4- a ... E - 0US m -i M r i US U Ci 0 Ui . Ci C) Ci. 4.. 9* Ci0 44. 4-S i C U i 5U - . ’- -) 0 C- c -CiOZ E 0 04 CiC C’ - E-.0 m N 4- 10 m E4...1 z 0 - C)4 -4 54-1 C)) 04Q). 0U $4i 4I - 40. U a) 0)U r -H 0) -a 0r- u 1-- 1% 4J ( C.) 4 0 0 4~J >1) C) r ’ (0 4 T - -4 U) C C) 0 *- C)0 - 4 f 04 C) C

NAVSPASUR System Performance Analysis

DTIC Science & Technology

1988-03-16

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Prime Contract Awards Alphabetically by Contractor, by State or Country, and Place. Part 6. (Dobbins Lou, Inc.-Fahey Machinery Co., Inc.)

DTIC Science & Technology

1989-01-01

0 (-4N4- H0 -.4C.) -. 4 a) () -40) -4 0 ) w 0N %- M C(00) z to IG0 -Iff1 ._40 N I 0 -4 4 5 0 ) L0)) 0 .-. 01-4~ . 0 .4NCJ0) 1-1-4 -4-4 0 )’ ao I -4N... 0 -4 00 0 -n O Olo(c x( c -d0 41r- -C4 N00 to II0 0 - I N N C1,1 0 r -4 -4 r-U 1 0 ... .J0)00N MLI-I0-41 1 00 o0 30- 30 30)mv0v-, 0 a o 5 Qo oN 0114/81 M...100000000000 4I <_1B4.4 110 0D 0n 0n 0 0 00 ofl W I Owl>u if ON 0C Or0N ON" 0 -I

Development of Flight Safety Prediction Methodology for U. S. Naval Safety Center. Revision 1

DTIC Science & Technology

1970-02-01

Safety Center. The methodology develoned encompassed functional analysis of the F-4J aircraft, assessment of the importance of safety- sensitive ... Sensitivity ... ....... . 4-8 V 4.5 Model Implementation ........ ......... . 4-10 4.5.1 Functional Analysis ..... ........... . 4-11 4. 5. 2 Major...Function Sensitivity Assignment ........ ... 4-13 i 4.5.3 Link Dependency Assignment ... ......... . 4-14 4.5.4 Computer Program for Sensitivity

76 FR 441 - Airworthiness Directives; Airbus Model A300 B4-600, B4-600R, and F4-600R Series Airplanes, and...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-01-05

... Airworthiness Directives; Airbus Model A300 B4-600, B4-600R, and F4-600R Series Airplanes, and Model C4-605R...-622, B4-605R, B4-622R, F4-605R, F4-622R, and C4-605R Variant F airplanes, certificated in any category...

Three Dimensional Object Recognition Using a Complex Autoregressive Model

DTIC Science & Technology

1993-12-01

3.4.2 Template Matching Algorithm ...................... 3-16 3.4.3 K-Nearest-Neighbor ( KNN ) Techniques ................. 3-25 3.4.4 Hidden Markov Model...Neighbor ( KNN ) Test Results ...................... 4-13 4.2.1 Single-Look 1-NN Testing .......................... 4-14 4.2.2 Multiple-Look 1-NN Testing...4-15 4.2.3 Discussion of KNN Test Results ...................... 4-15 4.3 Hidden Markov Model (HMM) Test Results

Management of MTOE Effective Dates Based on Equipment Availability. Phases I and II. MTO Dates I and MTO Dates II.

DTIC Science & Technology

1983-07-01

report are not to be construed as an official Department of the Army position, policy , or decision unless so designated by other official...4) ~ I- . ) 4CJn . 0.. . C M L4- Lz 4)-3 - 4 0O -4J . cnCD 04) 4-1 4 CA C E~ e.41 .C4- . .-. .- CLLJ CL mt 4) 4-4 0o m- >,0-.04 cOL 0 4.U,. 𔃺. C

Comparison of clinicopathological findings among patients whose mammography results were classified as category 4 subgroups of the BI-RADS.

PubMed

Leblebici, Ihsan Metin; Bozkurt, Suleyman; Eren, Turgut Tunc; Ozemir, Ibrahim Ali; Sagiroglu, Julide; Alimoglu, Orhan

2014-01-01

Our aim is to compare mammographic, demographic and clinicopathological characteristics of patients whose mammographies were classified as subgroups of BI-RADS 4 category (Breast Imaging - Reporting and Data System). In total, 103 patients with mammography (Senographe 600t Senix HF; General Electric, Moulineaux, France) results classified as BI-RADS 4 were included in the study. Demographic data (age, menopause, and family history) were recorded. All data were compared among BI-RADS 4 subgroups. In all, 68.9% (71/103), 7.8% (8/103) and 23.3% (24/103) the patients were in groups BI-RADS 4A, 4B and 4C, respectively. The incidence of malignancy was higher in Groups 4B and 4C than in Group 4A (p<0.05), but similar in Groups 4B and 4C (p>0.05). Mean age was lower in Group 4B than in Groups 4A and 4C (p<0.05). A positive family history was more common in Group 4A than in Group 4B (p=0.025). The frequency of menopausal patients was greater in Groups 4A and 4C than in Group 4B (p=0.021, and 0.003, respectively). The rate of malignancy was higher in Groups 4B, and 4C than in Group 4A. A positive family history was more common in Group 4A than in Group 4C. Groups 4A, and 4C patients tended to be older and were more likely to be menopausal than Group 4B patients.

The cytosolic tail of the Golgi apyrase Ynd1 mediates E4orf4-induced toxicity in Saccharomyces cerevisiae.

PubMed

Mittelman, Karin; Ziv, Keren; Maoz, Tsofnat; Kleinberger, Tamar

2010-11-22

The adenovirus E4 open reading frame 4 (E4orf4) protein contributes to regulation of the progression of virus infection. When expressed individually, E4orf4 was shown to induce non-classical transformed cell-specific apoptosis in mammalian cells. At least some of the mechanisms underlying E4orf4-induced toxicity are conserved from yeast to mammals, including the requirement for an interaction of E4orf4 with protein phosphatase 2A (PP2A). A genetic screen in yeast revealed that the Golgi apyrase Ynd1 associates with E4orf4 and contributes to E4orf4-induced toxicity, independently of Ynd1 apyrase activity. Ynd1 and PP2A were shown to contribute additively to E4orf4-induced toxicity in yeast, and to interact genetically and physically. A mammalian orthologue of Ynd1 was shown to bind E4orf4 in mammalian cells, confirming the evolutionary conservation of this interaction. Here, we use mutation analysis to identify the cytosolic tail of Ynd1 as the protein domain required for mediation of the E4orf4 toxic signal and for the interaction with E4orf4. We also show that E4orf4 associates with cellular membranes in yeast and is localized at their cytoplasmic face. However, E4orf4 is membrane-associated even in the absence of Ynd1, suggesting that additional membrane proteins may mediate E4orf4 localization. Based on our results and on a previous report describing a collection of Ynd1 protein partners, we propose that the Ynd1 cytoplasmic tail acts as a scaffold, interacting with a multi-protein complex, whose targeting by E4orf4 leads to cell death.

An Application of Content Analysis to Determine Congressional Behavior in Relation to the Defense Budget

DTIC Science & Technology

1977-06-01

4 (1 4J 4- r 4 JQ) C) wn 03 Z$ 4 1,4 - )t n 0 4H H- J> )- H( (D 00H 4J W0 ) U 44 )w09 ) C 0 HI4 H 0U 0S.Hr4Wa - S-i U00- 4 j )X:a 9. td 04 t 0 4 JJVW...W4E- 0d .04- 0() - 0 CA r Q-sm 4ww0 U000 Cpv to 0 4 0) 0.0 m (a 10-i 00 014 4 3UV u 1)0 0Uc2 0 02- 144 A: 40 9()0 O4’ w 20 C 04149> 0)" w -H u2 0) 04

All Prime Contract Awards by State or Country, Place, and Contractor. Part 22 (Aua Amer-Honduras)

DTIC Science & Technology

1990-01-01

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Dyess AFB, Texas, Revised Uniform Summary of Surface Weather Observations (RUSSWO). Parts A-F.

DTIC Science & Technology

1983-09-21

PRECIPITATION PSYCHROMETRICD@Y VS WIT SOlLD SNOWFALL MEAN AS TD DIV.- SNOW EPTH DR 81uts. WET SUIN. & DEW POINVj PART D CEILING VERSUS VISISIIITY PART P...OSSWVATOWS USCIA -5 OL..A ’RIOis tD ,T,00j OF 1.1% F0RM "I* OSSOtlIC - - -- -- ----------------- - -- - ---- -- -- -- - - - I.’):kL CLIMATOLOGY R’RANCH...F’.1 7.. -,4.1 38. 83 .8 89.1’ 81.4, 1,.4 8. 4 S9.4 6c. 8 . 5.4 8o. 84. 4 4 69.4’ cy.4. 1 8 9.6 8 Q.9 9’.2 . o.4 Td ’.([ 4 9n.4 Q.4 ’s4 0 ].4 9’.4

Geographic List of Prime Contract Awards. Oct 91 - Sep 92. FY92. (Barrington Rhode Isld - Ft Bliss Texas)

DTIC Science & Technology

1993-01-01

0) 0) 40 0 -4 (1(1m(1l N 00 -44--N 444(0 1 40 -4 oo<a000-4 0aQ 0-0 00Co -4 -40 00 o 0 0 200Cp-4 N/ Ii 4 al it0( ’A.N N N-4J1’(JN’ J- -4INA NONiN N...a 1 (004t H 4R M’ viN " la1-4 ino NNN 1(4 U1- 1C)CIMC’) 9590 #A-4 twoC𔃻 9110ý -4 1 coo (0 4 ) 0) Q)-4 (1)o IVn l ON0(000 00 411- 0COOP- 01-4 4)(0 0

Prime Contract Awards by FSC/SVC and Purchasing Office in Excess of $100,000. FY 1992 (1005 Guns thru 30 mm -- 8130 Reels and Spools)

DTIC Science & Technology

1993-01-01

gn -*( 0Q 0 00 N 40 a a:wo to00)0 . C4 L~.4 U.U.L f6 - 1 -l 00o.00 4 Cfl4 mlC4 P. q w-i N4 r- Z-i (A N f 6-0 -IIn 4c (A (fl i N r- -I .4 C4 w-4 (no 00...V40& X U -- C -- 0. - =: z 0.V 4L CLO U U .4 .4U isQ3t lb 4. Cl . c൰VLSC io&C -4 CL > . 0O ACCa I.- (A-1.. S4 It ;: 0 0 04 06 > t I .. C ..4 0 o 1

Dollar Summary of Federal Supply Classification and Service Category by Company, FY 87. Part 10. 5955-6650

DTIC Science & Technology

1987-01-01

0 9 LA- I 4 n * f6 IM Iý 4 m0 n -6 .4 M I4NO *0 0 C’ M VM0 tCJOP # 0 m v O a- 0 .4 -4 .4 -4 . -4 -4 .4 in 4 64 I -C6I *- 1 a 1- .0 6 1- V)f if. U...0H 0 xc w 0 W co <H Q4 Q- 0 C) 1 0 WU 0 1 H W IL < H w) Wj <) 4 1.- 0 H acca ~ cc xa 4 H H c .4 4)I c 0 I-H na zc cc 1- 40 m-c c IQ01 Z ZH 0 O w 0- a

All Prime Contract Awards by State or Country, Place, and Contractor, FY 88. Part 22. (Germany, F-Grenada)

DTIC Science & Technology

1988-01-01

444វ m< 0 4 4 4 4 4 4 4 44 ~ 4 4 4 4 4 4 4 4 ᝰ n " o o(- Iu uU F u0 0 F 0 0999)04 tD J2%F 9’O QU U u u u U (-00(4 F C)C (n1> F ) C-) 4 f)m-( 40 O...40000. ŕ 0100--4 𔃺 000 L-L)aJOC L. 0 C C 0 C00a00C0 >0 C 00000 0 000 -1 000-4 1 oo (0(0 xᝰ < U)(DO(0 (D(0 (D (D(D(0 00 1-C co Mr- oo tD - -r-. -0...I I)la) ’ I ~ ~ "~ .~ .) .0 . I.. .. .I " OCI ɘ" I w 4-IOU T(0 4 - o v0 m tD m(0 v m w -LOflC)0) 0)’.O ") -I -CA wI(0 I ɘ" 1 0400C’)m!-1’- --40), C

Dollar Summary of Federal Supply Classification and Service Category by Company. Part 5 (Z119-Z299)

DTIC Science & Technology

1990-01-01

a 1- U) 1- 0 W)U ) ~ U ) ~ ~ U ) ~ ~ U 4 U 00I- 43m m 0 0WIZ 4o x - Ip I 4 ce - Ne- " OI ZI4 0> I- E 0W 6 w m. U .4 CK()1 . 0 (A- F- " a U C ).- U C...I C I 11 Ip I I* a I C C C C C c c C c C c C C c c c c C c C rIi; 1It " . . . . . . . .I * I co = 2 I. I 11 4 - 4 -4 - 4 -4 -4 - 4 -4 - - IW a4 0 4...4. a 2 3S 3 m -c in 03 4 C 2 U 4 U-c Us o z " Co VOZ U . . c~ PU- U Ř C C 1 in O0. ) 34 cc C 1-4 0 =n in " I- C (A 0w 0-4 044 0 0 0 0. U 0 4w h I01 I

Department of the Army Justification of Estimates for Fiscal Year 1987, Submitted to Congress February 1986. Operation and Maintenance, Army. Volume 1.

DTIC Science & Technology

1986-02-01

Izu ac)L 4)V C rio 2C E-4-4 in 0) M) V VOz V C 0 d 0C 0 C)4 0 C 4 tiC r. . a) ". HL 1- o 0) CC -4 A.) w 4 1-4 :5 c) r_ cC c Ř 0 0 w) W4 0 P-4 a) 0 S 0...CL.C 0.491 hi% % A ~ 9.~§~: ~:~-:*~~.*.-~*:*~~; o~-a’~--o~"T q - 0 t- O OC M -Z oo ’- -- iP - LL. 00 -)N - - CYu LLL; 00-0’JUL) . 0 C n% coO 0 TN N: O om...Crzjz 41 - . *1 4-a 4. -4 . A~’i m* * W0 : ) c a): (0 4.. S 4.10t - *1 5.n- *0 M* -4 0 cn 0 12 ’a .3 w8 -4 C14 0 w . 0 4-4 C ~ 0 * *~ 4J CZ4 ~ 5 D IP tv r

Capability 9.4 Servicing

NASA Technical Reports Server (NTRS)

Moe, Rud

2005-01-01

This paper presents viewgraphs on capability structure 9.4 servicing. The topics include: 1) Servicing Description; 2) Benefits of Servicing; 3) Drivers & Assumptions for Servicing; 4) Capability Breakdown Structure 9.4 Servicing; 5) Roadmap for Servicing; 6) 9.4 Servicing Critical Gaps; 7) Capability 9.4 Servicing; 8) Capability 9.4.1 Inspection; 9) State-of-the-Art /Maturity Level /Capabilities for 9.4.1 Inspection; 10) Capability 9.4.2 Diagnostics; 11) State-of-the-Art/Maturity Level /Capabilities for 9.4.2 Diagnostics; 12) Capability 9.4.3 Perform Planned Maintenance; 13) State-of-the-Art /Maturity Level /Capabilities for 9.4.3 Perform Planned Maintenance; 14) Capability 9.4.4 Perform Unplanned Repair; 15) State-of-the-Art /Maturity Level /Capabilities for 9.4.4 Perform Unplanned Repair; 16) Capability 9.4.5 Install Upgrade; 17) Capability 9.4.5 Install Upgrade; 18) State-of-the-Art /Maturity Level /Capabilities for 9.4.5 Install Upgrade; 19) Capability 9.4.6 Planning, Logistics, Training; and 20) State-of-the-Art /Maturity Level /Capabilities for 9.4.6 Planning, Logistics, & Training;

Prime Contract Awards Alphabetically by Contractor, by State or Country, and Place, Fiscal Year 1987. Part 9. Hawthorne Srvc. & Medical U SC-Input Output Technology.

DTIC Science & Technology

1987-01-01

0 0 m 0 V7 a Mo00tI 04 aF 04 0 U..04 0 0 4 0004 000 0004 00v4l A a 1 o < 1 - 08- 0 m 4N00ŕ-1.- 0 0o1-) 000-) CN 00- co D W -co 00- W- ca 0 0 4 004...a 00 0 ’nw 000 gr Go00 C- 4)NN 01?--(- ... J 40 CAD 00 00- -40-00 0 000 3 4 ’- m- -A4 (D a- E ’ w- Cl m- 0 0 M4 0-l (14 af ((0-C’N 0A (4 V) 0 0 0)0...4, -4-4 lin n in -4 (00(4 I -- 10-4( IC) Mum0 1 r a I0 > 0 0. ) 0 1C 04 ’ -4 = tC z -4 4 ( )- 4. J I M 04 N af .- C.-4- C14 If,4 cl UI 0, C r

The role of the CXC chemokines platelet factor-4 (CXCL4/PF-4) and its variant (CXCL4L1/PF-4var) in inflammation, angiogenesis and cancer.

PubMed

Vandercappellen, Jo; Van Damme, Jo; Struyf, Sofie

2011-02-01

Chemokines are chemotactic cytokines which recruit leukocytes to inflammatory sites. They also affect tumor development and metastasis by acting as growth factor, by attracting pro- or anti-tumoral leukocytes or by influencing angiogenesis. Platelet factor-4 (CXCL4/PF-4) was the first chemokine shown to inhibit angiogenesis. CXCL4L1/PF-4var, recently isolated from thrombin-stimulated platelets, differing from authentic CXCL4/PF-4 in three carboxy-terminally located amino acids, was found to be more potent than CXCL4/PF-4 in inhibiting angiogenesis and tumor growth. Both glycosaminoglycans (GAG) and CXCR3 are implicated in the activities of the PF-4 variants. This report reviews the current knowledge on the role of CXCL4/PF-4 and CXCL4L1/PF-4var in physiological and pathological processes. In particular, the role of CXCL4/PF-4 in cancer, heparin-induced thrombocytopenia and atherosclerosis is described. Copyright © 2010 Elsevier Ltd. All rights reserved.

Dollar Summary of Prime Contract Awards by Contractor, State or Country, and Place, FY 85. Part 1 (IDSCR Inc - Czetli Jess & Son In).

DTIC Science & Technology

1985-01-01

m.-I-I.m.m0IIF- - . I00 I- I.-fI.-I- . 0 4 4 64*.4 444@da *444 004 4 o aG aea a& 4 *a 0 *a *a 6.-a *a60 4 e 4 GOO6Uea44 * Ao i 4 1 1 0 M a*a- -- 4-1...4 a~a .4 . 1 4 1 I -4 0 Z(0 = 0 0 CX o m ag m- C- m .-4.. 0c -* . a4 E 041 0 U C)1-0 1 W.C.Z0404 C 1C4 41 -C -C z. 40.- w - - Cx L C 0 40 -C -C 3-4...w . - " 0 0 14 ZI 0 6 " -I U0 > - z C aG 0I - 0 C w (0 61 ~- wo w g x b. I. . . .- . L 0 V 61 U 0 0 w w " CA I 0 U 61 4 4 U 61 1 E4 -C 4 -- I I 0 61

8111/8116 Security Police Staff Officers 8121/8124 Security Police Officers AFSC: 81XX

DTIC Science & Technology

1992-02-01

c 6I4 .1 4 6 5 . 5 6 -6 0 m 0 60 . 0.. C afa 0 -6 0 1 0 .4 L 0 CL & f6 C 6.4 6%. 4 040E .~ ~ a 0 0.41.ft i 0 a 0w m a 2m 2 0 0. Mv 0U 4 0. L.~ 0 0ty...m ~ SC 6& Ct D0 CC Z~C)d Ř-66 64 I Ř.64C0 Ř E~ L 𔄀 6660 LO U64 W . .0 C 𔄀 -4 0L 6 0 L 1- 4 0ŘC C #.4 f6 ൶ 0 151 6W ~ )d6I.ILC E 11 .4 6.4...L - - R~ . ( *U # ACCa .4 % 40 a - 4- 1 4 4-L 0 *-46.40 50 a .40C CL 0 Ŕ 1 0. 0 OUUCC>CU.U0C4-LSa LC .CaC CW~ift-4C .4,4f L .4 -S(( a-..CA a COC *-. 4

(NH4)2SO4 heterogeneous nucleation and glycerol evaporation of (NH4)2SO4-glycerol system in its dynamic efflorescence process

NASA Astrophysics Data System (ADS)

Cai, Chen; Luan, Ye-mei; Shi, Xiao-min; Zhang, Yun-hong

2017-02-01

Using the FTIR-ATR technique, we investigated the heterogeneous nucleation process of aqueous (NH4)2SO4 binary droplets and (NH4)2SO4/glycerol ternary droplets. From the red shift of δ-NH4+ with a linearly declining relative humidity (RH), the ERHs of pure (NH4)2SO4 droplets and mixed (NH4)2SO4/glycerol droplets with different organic-inorganic ratio (OIR) of 1:4, 1:2 and 1:1 ranges from ∼51.9 to ∼34.9%, ∼49.8 to ∼33.0%, ∼48.0 to ∼30.6% and ∼43.7 to ∼25.2%, respectively. From the changing absorbance of δ-NH4+ band, we determined the heterogeneous nucleation rates of crystalline (NH4)2SO4 in the pure and mixed droplets. The interfacial tension between an (NH4)2SO4 critical nucleus and surrounding (NH4)2SO4 solution was determined using classical nucleation theory and experimental data to be 0.031 ± 0.002 J m-2. Evaporation of glycerol in (NH4)2SO4/glycerol ternary droplets are also studied to be restrained by participation of (NH4)2SO4. Determined vapour pressure of glycerol is on the same magnitude with results from previous studies.

75 FR 76926 - Airworthiness Directives; Airbus Model A300 B4-600, B4-600R, and F4-600R Series Airplanes, and...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-12-10

... Airworthiness Directives; Airbus Model A300 B4-600, B4-600R, and F4-600R Series Airplanes, and Model C4-605R... airplanes; Model A300 B4-605R and B4-622R airplanes; Model A300 F4-605R and F4-622R airplanes; Model A300 C4...

Functional Polymers and Sequential Copolymers by Phase Transfer Catalysis. Synthesis of Thermotropic Side-Chain Liquid Crystalline Polymers Containing a Poly(2,6-Dimethyl-1,4-Phenylene Oxide) Main Chain.

DTIC Science & Technology

1986-10-01

bromovalerate (Aldrich, 99%), 5-bromovaleronitrile (Aldrich, 95%), and 11-bromoundecanoic acid (Aldrich, 99%) were used without further purification. 4...atic proton’s). 71 Cm, 4 aromatic X~tons). C. Synthesis of 4- 4-oxybipheny1 butyrnc acid , 4-(4-inethoxy 4’-oxy- I hen 1 butyrnc acid , 5-(4-oxybipheny1...valeric acid , 5-(4-inethoxy-4-oxy- bi heny1 valeric acid . 11- 4-ox bipheny1 undecanoic acid and 11- 4-inethox -4 -ox biphenylundecanoic acid . The

75 FR 41237 - Public Land Order No. 7746; Withdrawal of Public Lands, South Fork of the American River; California

Federal Register 2010, 2011, 2012, 2013, 2014

2010-07-15

... the American River: Mount Diablo Meridian T. 11 N., R. 9 E., Sec. 10, NW\\1/4\\NW\\1/4\\ and S\\1/2\\; Sec...\\,SW\\1/4\\, and SE\\1/4\\; Sec. 32, N\\1/2\\NE\\1/4\\, SW\\1/4\\NE\\1/4\\, W\\1/2\\, and S\\1/2\\SE\\1/ 4\\. T. 11 N., R. 10 E., Sec. 18, lots 5, 6, and 7, and NW\\1/4\\NE\\1/4\\NW\\1/4\\; Sec. 22, NW\\1/4\\SE\\1/4\\SW\\1/4\\, and that...

Prime Contract Awards Alphabetically by Contractor, by State or Country, and Place, Fiscal Year 1987. Part 12. Mantech International Corporation-Modular Devices, Incorporated.

DTIC Science & Technology

1987-01-01

VLA00- VN00-.t0CO 00-4 000 -I 00 zo 00:< I-0.O- 4"NNmOOO t rNN 3-4-- 4CioL C) r ol0 00(1 300 0 )NO O <-0 :I Z v f- 0)(m(0( MOLA 0)4 40 ZIiIf0 N _( t- l...V0 < 0) lac .- 4I -4 .. 40) WI)v 4󈧄)Ř 4.--4 0 ~ ~ ~ ~ ~ -O c (00 0)-04-00- . -4 MOLA , C0) m -4 e -41-" .1 LA nII ’III IX (00< I 4 4-f-4 -- 4

Alpha List of Prime Contract Awards. Oct 91 - Sep 92. FY 92. (Seatex as - Steiny and Company Inc)

DTIC Science & Technology

1993-01-01

0 - -a. a’ 16 00 .4 .4 4-. 4 v B.~~ 00-0m.4(43. IO a C~~~~~~ I-~ - 5 5 0 0 44 .4 6 1 46 0 4 a 44 L 𔃾 IA z 02 . 0 1- a ’ or v4- P- to (A w t 44 c...34 it < C0. 400 Q 0o. ) 0 ) Q 1-4 (A 0 0 ofo "u’ C) 0 -4 of14 0a ca $-4 0 C0 I-. -I 1 0 ) 0 -4 It 2 Wj 5 ±1 Ws WJ W W~ H 0 )03 -s if X.?ULIM 2n -4 zoo 0 4 C’N...in INI - 0 c) (714 C- 5 M C4 C14 r4 -4 Cl) -4 a

Alpha List of Prime Contract Awards. Oct 91 - Sep 92. FY 92 (Branscome Julius Inc - Chriscott Supply)

DTIC Science & Technology

1993-01-01

821702I0(04o ItIT 4444 9 0 cCNi "NIN 04 (0J a𔃻 47f-f a 1 >,Of enC o<i 020z0 o 0000 N 0)100 43 1)(1C) ’(1)V ý-lIA N! (’l( 0) -4 M LA 0. (-10 4-I I -4 -4...I I enC > N41a r0))00) 4 o mm q 7 40)0 ID)0)(0r-NO4 m0) 0 04( o r- N I m 0"-4-4(1)0) 0(1 4)100 II CDC>00 00 00 00 000t00 0I0to- -4--4-41000 10 11 D0>1...0004 11--4 WO"CN, .- 4 -4 -4.-4 -4IUU 0n C) A-r- M M c ( n00 nU,0) In.-4 W4 it0 1I (00 4 it 0 m ENc --IO <>" ൈ ý 0 0’-441 -4 m F" -4 t NN04C’JO< 1ý- Ul

Prime Contract Awards Alphabetically by Contractor, by State or Country, and Place. Part 7 (Delta Engineering Services - Electronic Design Engr)

DTIC Science & Technology

1990-01-01

M m CV) In4 4 m -nW nmU I C4 innonn 02-40 o . M 1 Ŝ if f8 r- r-4 -V ,MT "f.mmt ,m -P - .I)t )o I Mf *in 040 if -P4-m MI N--4-4-4- PI rI.PP NN 4 0 r...4 U000 0 4 NIO G0.0 se f8 a0 ag0l 000 w00 0040 00c OD 0W040o4O EW 1U-4 £a Oo* -Q4.4 100 040 COO31 00n 00313 00 0-0,0- $.-a£ 40-1 a Uls. 0 0 .4-4 M NN...01.4 0 3 .40iM16t-00t-40.-4 OW 0dM’ t& 0r 0 8o acCa 0 a o o E00 1,12 0008-4 .4 00 0(0A - 3: 60 1 000 00 00 00 0 V0 ( A 1.-*S~ Z.-0N0 -I 0N 4N A)w 0

Alpha List of Prime Contract Awards. Oct 92-Sep 93. FY93. (Sets Technology Inc. - System/Technology Development). Part 17

DTIC Science & Technology

1994-03-01

00)0oN e4 N I cacao I -4N Y 4 .0 U)nendo4)0(0 0 00a) to U)(a I)0).Ř -4 i G I ) a)CV) 0 a)Nf4r0 0) 0to n 4- 4 44-N gV24 CqIt n0I I 0)0a coo 1 Ow 0 0 0...4 0 M0 W 0 0 0 W0.-4-4W-40 -40) -4 0 M flN MN T% N lc4M-4N 1. -0 -40(0)WG CO I cacao ) 11J0 -.100) ) N N ON NON-0 (0.-. -4 - - CO) -0)ON- X- N I000...c00 W -Nu 4Wf-C) IL -4 M LLa. N C 0 0 -4 -40 o z X4 0-4-.N U c 3000 K 4N qt NY N .N az zI cacao III N 0 O 0 Ca 0 00 N0z N O I 000 UM 0I 00 11L 400 4

The Rab4 effector Rabip4 plays a role in the endocytotic trafficking of Glut 4 in 3T3-L1 adipocytes.

PubMed

Mari, Muriel; Monzo, Pascale; Kaddai, Vincent; Keslair, Frédérique; Gonzalez, Teresa; Le Marchand-Brustel, Yannick; Cormont, Mireille

2006-04-01

Insulin regulates glucose uptake in the adipocytes by modulating Glut 4 localization, a traffic pathway involving the endocytic small GTPases Rab4, Rab5, and RabThe expression of the Rab4 effector Rabip4 leads to a 30% increase in glucose uptake and Glut 4 translocation in the presence of insulin, without modifications in the basal condition. This effect was not due to modifications of Glut 4 expression or insulin signaling, suggesting that Rabip4 controls Glut 4 trafficking. We present evidence that Rabip4 defines a subdomain of early endosomes and that Rabip4 is redistributed to the plasma membrane by insulin. Rabip4 is mostly absent from structures positive for early endosome antigen 1, Rab11 or transferrin receptors and from Glut 4 sequestration compartments. However, Rabip4 vesicles can be reached by internalized transferrin and Glut 4. Thus, Rabip4 probably defines an endocytic sorting platform for Glut 4 towards its sequestration pool. The expression of a form of Rabip4 unable to bind Rab4 does not modify basal and insulin-induced glucose transport. However, it induces an increase in the amount of Glut 4 at the plasma membrane and perturbs Glut 4 traffic from endosomes towards its sequestration compartments. These observations suggest that the uncoupling between Rabip4 and Rab4 induces the insertion of Glut 4 molecules that are unable to transport glucose into the plasma membrane.

Controlled synthesis of Ag{sub 3}PO{sub 4}/BiVO{sub 4} composites with enhanced visible-light photocatalytic performance for the degradation of RhB and 2, 4-DCP

DOE Office of Scientific and Technical Information (OSTI.GOV)

Qi, Xuemei; School of Environmental and Chemical Engineering, Shanghai University of Electric Power, Shanghai 200090; Gu, Miaoli

Highlights: • Ag{sub 3}PO{sub 4}/BiVO{sub 4} composites were synthesized by in-situ precipitation method. • Ag{sub 3}PO{sub 4}/BiVO{sub 4} is more efficient than pure Ag{sub 3}PO{sub 4} and BiVO{sub 4} for RhB and 2, 4-DCP degradation. • Ag{sub 3}PO{sub 4}/BiVO{sub 4} can act as a high performance and low cost photocatalyst. - Abstract: Ag{sub 3}PO{sub 4}/BiVO{sub 4} composites were fabricated by in-situ precipitation method. Results showed that Ag{sub 3}PO{sub 4}/BiVO{sub 4} composites exhibited higher photocatalytic activity than that of pure BiVO{sub 4} and Ag{sub 3}PO{sub 4} sample under visible light irradiation. The effect of Ag{sub 3}PO{sub 4}:BiVO{sub 4} ratio on themore » photocatalytic activity was systemically studied and the optimum molar ratio of Ag{sub 3}PO{sub 4}:BiVO{sub 4} was 1:5. The Ag{sub 3}PO{sub 4}/BiVO{sub 4}-5 exhibited excellent photocatalytic activity for the degradation of Rhodamine B (ca. 92% in 30 min) and 2, 4-dichlorophenol (ca. 84% in 180 min) under visible light irradiation. The enhanced photocatalytic activity could be mainly ascribed to the suitable Ag{sub 3}PO{sub 4}/BiVO{sub 4} heterojunction interface and the smaller particles of Ag{sub 3}PO{sub 4} compared to pure Ag{sub 3}PO{sub 4} particles which could promote the separation of photoinduced electron-hole pairs. The Ag{sub 3}PO{sub 4}/BiVO{sub 4} composite can significantly reduce the silver consumption compared to the pure Ag{sub 3}PO{sub 4}. It is worth noting that Ag{sub 3}PO{sub 4}/BiVO{sub 4} composite can act as a high performance and low cost visible-light-driven photocatalyst for environmental remediation.« less

The COOH-terminal peptide of platelet factor-4 variant (CXCL4L1/PF-4var47-70) strongly inhibits angiogenesis and suppresses B16 melanoma growth in vivo.

PubMed

Vandercappellen, Jo; Liekens, Sandra; Bronckaers, Annelies; Noppen, Samuel; Ronsse, Isabelle; Dillen, Chris; Belleri, Mirella; Mitola, Stefania; Proost, Paul; Presta, Marco; Struyf, Sofie; Van Damme, Jo

2010-03-01

Chemokines influence tumor growth directly or indirectly via both angiogenesis and tumor-leukocyte interactions. Platelet factor-4 (CXCL4/PF-4), which is released from alpha-granules of activated platelets, is the first described angiostatic chemokine. Recently, it was found that the variant of CXCL4/PF-4 (CXCL4L1/PF-4var) could exert a more pronounced angiostatic and antitumoral effect than CXCL4/PF-4. However, the molecular mechanisms of the angiostatic activities of the PF-4 forms remain partially elusive. Here, we studied the biological properties of the chemically synthesized COOH-terminal peptides of CXCL4/PF-4 (CXCL4/PF-4(47-70)) and CXCL4L1/PF-4var (CXCL4L1/PF-4var(47-70)). Both PF-4 peptides lacked monocyte and lymphocyte chemotactic activity but equally well inhibited (25 nmol/L) endothelial cell motility and proliferation in the presence of a single stimulus (i.e., exogenous recombinant fibroblast growth factor-2). In contrast, when assayed in more complex angiogenesis test systems characterized by the presence of multiple mediators, including in vitro wound-healing (2.5 nmol/L versus 12.5 nmol/L), Matrigel (60 nmol/L versus 300 nmol/L), and chorioallantoic membrane assays, CXCL4L1/PF-4var(47-70) was found to be significantly (5-fold) more angiostatic than CXCL4/PF-4(47-70). In addition, low (7 microg total) doses of intratumoral CXCL4L1/PF-4var(47-70) inhibited B16 melanoma growth in mice more extensively than CXCL4/PF-4(47-70). This antitumoral activity was predominantly mediated through inhibition of angiogenesis (without affecting blood vessel stability) and induction of apoptosis, as evidenced by immunohistochemical and fluorescent staining of B16 tumor tissue. In conclusion, CXCL4L1/PF-4var(47-70) is a potent antitumoral and antiangiogenic peptide. These results may represent the basis for the design of CXCL4L1/PF-4var COOH-terminal-derived peptidomimetic anticancer drugs.

Novel teleost CD4-bearing cell populations provide insights into the evolutionary origins and primordial roles of CD4+ lymphocytes and CD4+ macrophages

PubMed Central

Takizawa, Fumio; Magadan, Susana; Parra, David; Xu, Zhen; Korytář, Tomáš; Boudinot, Pierre; Sunyer, J. Oriol

2016-01-01

Tetrapods contain a single CD4 co-receptor with four immunoglobulin domains that likely arose from a primordial two-domain ancestor. Notably, teleost fish contain two CD4 genes. Like tetrapod CD4, CD4-1 of rainbow trout includes four immunoglobulin domains while CD4-2 contains only two. Since CD4-2 is reminiscent of the prototypic two-domain CD4 co-receptor, we hypothesized that by characterizing the cell types bearing CD4-1 and CD4-2, we would shed light into the evolution and primordial roles of CD4-bearing cells. Using newly established monoclonal antibodies against CD4-1 and CD4-2, we identified two bona fide CD4+ T-cell populations, a predominant lymphocyte population co-expressing surface CD4-1 and CD4-2 (CD4 DP), and a minor subset expressing only CD4-2 (CD4-2 SP). While both subsets produced equivalent levels of Th1, Th17, and Treg cytokines upon bacterial infection, CD4-2 SP lymphocytes were less proliferative and displayed a more restricted TCRβ repertoire. These data suggest that CD4-2 SP cells represent a functionally distinct population and may embody a vestigial CD4+ T cell subset, the roles of which reflect those of primeval CD4+ T cells. Importantly, we also describe the first CD4+ monocyte/macrophage population in a non-mammalian species. Of all myeloid subsets, we found the CD4+ population to be the most phagocytic, while CD4+ lymphocytes lacked this capacity. This study fills in an important gap in the knowledge of teleost CD4-bearing leukocytes thus revealing critical insights into the evolutionary origins and primordial roles of CD4+ lymphocytes and CD4+ monocyte/macrophages. PMID:27183628

Icing Nozzle Element Optimization Test, January 1979

DTIC Science & Technology

1979-08-20

71 1 iit miir -. l 6-’ 1P.Ss L-0 1 .C1IC O (W.E xW N 0.I NA UO9 I O 0 S.. U VS..4*( SS~i4.4P4 66 hi (S ~ .4.4.4..4 (5 4J 6-(55 455 PC CI +Uli I-L I A...jIP In MCr (.’ tJ m w.. * WEL (*£7 £4lw Il 0 S .1 w. 0E 0 C00 0 0 CC 0 M7.M 4L ty4llm .0:0 0.-C U.~. f4 £ U(J M w -w w w .4 .0 e *w N cm *4** In C30...0,000). .- EL 71 [WW-PKL4W’Oj 3M] AO £101 a a 2. 4-- 1 L- - .4 f- . 74 V. - 3 0 W *~~~ 74- .C? U-. 4 ~ N. 5.0 ~ U 11 0 6+0 LLW. . . . . . . . .5-40

Prime Contract Awards Alphabetically by Contractor, by State or Country, and Place. Part 7. (Fahey Watts Architects-General Contract and Sales)

DTIC Science & Technology

1989-01-01

0 -m Il 5 ))40 . I: 0 40-4-4 -x000) of I 00-4qN< 66 ."eN *-4NI g - *N .40)-4 .4 U1.4 MOMO t00 m m’ C-eq an .- 4-4 eqI 0 .-44 1 ::-4...991 M (0N lice x W (A 4 4C (5n ( U) n44 1-44e mlt w. < Z 91 (0N eq4 c 0 a >- 0 0u >- >- 00X 1- 0 1-0o 1- cc I-- 0 0 C I M C14 91 -4 W. cc . 5 0D 0 -. 1 .1...001 - 00 IO 0 ( NC1n1- 1-1 C90 1 M 4 I 9(no0 1-- 0 4C 0 . 4 4 ~i 0 - 5 <C 4 ZNNZ 0 91 0 j

Summary of Meteorological Observations, Surface (SMOS) for Providence, Rhode Island

DTIC Science & Technology

1988-12-01

4 0 0 1 -go 5 0 V IV4 0 %.. - 0 N 5.0 10-. c. N 0 0 -i 030 N p - S 0 r- > 0o o .. 5.. s . N ) 0. & 1. I 0 4,0 C ) " "i 025 - 4 C. .4, S.’ 100 *3 t...4 . 03- 6 p4 2-4 t4’ 0O46)4 >. 00 00~ 0 U $.- 100 -. ".1. 4 0 100 0.0 1 ol5~ 0 0 d d 0. 0 >o0 040 ~. 03- 1 46 - .OpA. I)01 F.p 0)’ > 4) Ol ti 4 0 r...82170 124)4) 9.0 t. 16id4 0 0 𔃺 IV 0 w241 -Pto to16 06 .4’ r16 0.4r 04’ 12a 0 X1c2 1 12.0 0 P. .0 -P 0 100 0 16 0 >’ V0 C’.0 4) 𔃺.0 0 C𔃾-4-0 0. 202r

Synthesis of 7-(2,4-dichlorophenyl)-D-erythro-3-hydroxy-5-heptanolide, 6-(2,4-dichlorophenyl)-D-erythro-2,4-dihydroxyhexane-1-sulfonic acid, and 6-(2,4-dichlorophenyl)-D-erythro-2,4-dihydroxyhexylphosphonic acid.

PubMed

Hodosi, G; Galambos, G; Podányi, B; Kuszmann, J

1992-03-02

6-(2,4-Dichlorophenyl)-D-erythro-1,2,4-hexanetriol, synthesised from D-glucose, was partially silylated, then reacted with 2-methoxypropene to afford 1-O-tert-butyldimethylsilyl-6-(2,4- dichlorophenyl)-2,4-O-isopropylidene-D-erythro-1,2,4-hexanetriol (17). Desilylation of 17 gave 6-(2,4-dichlorophenyl)-2,4-O-isopropylidene-D- erythro-1,2,4-hexanetriol, which was converted into the 1-tosylate 18 and the 1-bromo derivative 19. Reaction of 18 with potassium thiolbenzoate gave, after debenzoylation, oxidation, and deprotection, 6-(2,4-dichlorophenyl)-D-erythro-2,4-dihydroxyhexane-1-sulfonic acid (4). Reaction of 18 or 19 with triethyl phosphite gave, after deprotection, 6-(2,4-dichlorophenyl)-D-erythro-2,4-dihydroxyhexyl-phosphonic acid (5), and reaction of 19 with potassium cyanide gave, after subsequent hydrolysis and deprotection, 7-(2,4-dichlorophenyl)-D-erythro-3-hydroxy-5-heptanolide (3).

Novel biotransformation process of podophyllotoxin to 4 β-sulfur-substituted podophyllum derivates with anti-tumor activity by Penicillium purpurogenum Y.J. Tang.

PubMed

Bai, J-K; Zhao, W; Li, H-M; Tang, Y-J

2012-01-01

According to the structure-function relationship of podophyllotoxin (PTOX) and its analogue of 4'- demethylepipodophyllotoxin (DMEP), the 4 β-substitution of sulfur-containing heterocyclic compounds with a carbon-sulfur bond at 4 position of PTOX or DMEP is an essential modification direction for improving the anti-tumor activity. So, four novel 4 β-sulfursubstituted podophyllum derivatives (i.e., 4β -(1,2,4-triazole-3-yl)sulfanyl-4-deoxy-podophyllotoxin (4-MT-PTOX), 4β-(1,3,4- thiadiazole-2-yl)sulfanyl-4-deoxy-podophyllotoxin (4-MTD-PTOX), 4β-(1,2,4-triazole-3-yl)sulfanyl-4-deoxy-4' -demethylepipodophyllotoxin (4-MT-DMEP), and 4β-(1,3,4-thiadiazole-2-yl)sulfanyl-4-deoxy-4'-demethylepipodophyllotoxin (4-MTD-DMEP)) were designed and then successfully biosynthesized in this work. In the novel sulfur-substituted biotransformation processes, PTOX and DMEP was linked with sulfur-containing compounds (i.e., 3-mercapto-1,2,4-triazole (MT) and 2-mercapto-1,3,4-thiadiazole (MTD)) at 4 position of cycloparaffin to produce 4-MT-PTOX (1), 4-MTD-PTOX (2), 4-MT-DMEP (3), and 4-MTD-DMEP (4) by Penicillium purpurogenum Y.J. Tang, respectively, which was screened out from Diphylleia sinensis Li (Hubei, China). All the novel compounds exhibited promising in vitro bioactivity, especially 4-MT-PTOX (1). Compared with etoposide (i.e., a 50 % effective concentration [EC(50)] of 25.72, 167.97, and 1.15 M), the EC(50) values of 4-MT-PTOX (1) against tumor cell line BGC-823, A549 and HepG2 (i.e., 0.28, 0.76, and 0.42 M) were significantly improved by 91, 221 and 2.73 times, respectively. Moreover, the EC(50) value of 4-MT-PTOX (1) against the normal human cell line HK-2 (i.e., 182.4 μM) was 19 times higher than that of etoposide (i.e., 9.17 μM). Based on the rational design, four novel 4 β-sulfur-substituted podophyllum derivatives with superior in vitro anti-tumor activity were obtained for the first time. The correctness of structure-function relationship and rational drug design was strictly demonstrated by the in vitro biological activity tests.

Study of Raster Metafile Formats.

DTIC Science & Technology

1985-01-01

0, 04 0 41 a4.4 a 00 ".0 06me 0 a +1 4 a a aU 0.4 060. 41 6 41 0 6 66 4 6 £4 6 N 4041 0 ;,4 *,10*64 NO4 066 a 4140 00 .414103w 4-4 ~’ a41 06 ft406...0a.44* 5 444. 44, .4 A "a 44014 0,14 4164 00 2 44 aV Loc 4 14 4 1 54 . A s o 6 . 4a UN a 4114 A 0, 4140 50 .. a4 Ne e-C 42 0 N4 M 0.44 4 3 a 0 000...use of 8-bit characters and the SI, SO and ES. control codes within the text string, in accordance with AISI X3.41 and ISO 2022. The ALTERNATE

Relativistic Atomic Data for Lines in Ge-Like Sm and Eu Ions

NASA Astrophysics Data System (ADS)

Nagy, O.; El Sayed, Fatma

2012-11-01

Energies, wavelengths, transition probabilities, and oscillator strengths have been calculated for the 4s24p2 - 4s4p3, 4s24p2 - 4s24p4d and 4s4p3 - 4p4 allowed transitions in heavy Ge-like Sm and Eu ions. The fully relativistic Multiconfiguration Dirac-Fock (MCDF) method taking into account both the correlations within the n = 4 complex and the quantum electrodynamic (QED) effects have been used in the calculations. MCDFGME code is used to calculate electron impact excitation cross sections for the 4s24p2 - 4s4p3, and 4s24p2 - 4s24p4d transitions with plane-wave Born approximation. The results of SmXXXI and Eu XXXII are compared with HFR method results.

Aircraft Crash Survival Design Guide. Volume I. Design Criteria and Checklists. Revision

DTIC Science & Technology

1980-12-01

5.7.2 Types of Systems . . . . . . . .. . 98 5.7.3 General Design Criteria .............. 106 5.7.4 Webbing and Attachments ........... ... 113 5.7.5...EO 00 1 2w 4 H Ix Q 4) C 9 4) I ( DH 4 U >1 040 ~V M 𔃺 4J 4)0 -,4U𔃾 U 0,.,q -- a Le Wx-i )U 4J EUq 0 -.4 (D 0󈧰-U CO .4 (4 U 0 41~ 4-4-4 V41 402 0 0...in lightweight systems. Experience has shown that it is 106 S fl lilii1i:I i~i] -l .-r- "----’.----’----- ..--.. .... 350 max Shoulder harness fitting

Tough soluble aromatic thermoplastic copolyimides

NASA Technical Reports Server (NTRS)

Bryant, Robert G. (Inventor)

2000-01-01

Tough, soluble, aromatic, thermoplastic copolyimides were prepared by reacting 4,4'-oxydiphthalic anhydride, 3,4,3',4'-biphenyltetracarboxylic dianhydride and 3,4'-oxydianiline. Alternatively, these copolyimides may be prepared by reacting 4,4'-oxydiphthalic anhydride with 3,4,3',4'-biphenyltetracarboxylic dianhydride and 3,4'-oxydiisocyanate. Also, the copolyimide may be prepared by reacting the corresponding tetra acid and ester precursors of 4,4'-oxydiphthalic anhydride and 3,4,3',4'-biphenyltetracarboxylic dianhydride with 3,4'-oxydianiline. These copolyimides were found to be soluble in common amide solvents such as N,N'-dimethyl acetamide, N-methylpyrrolidinone, and dimethylformamide allowing them to be applied as the fully imidized copolymer and to be used to prepare a wide range of articles.

A Graphical Test Bed for Analyzing and Reporting the Results of a Simulation Experiment.

DTIC Science & Technology

1982-03-01

I I WtO VI pWIf Mac 000 1 *eo I .. 0 0 I-In olu *~~~ in. I I ~ %flat us I JZ S x.4 0. rm I OOw pm - ^6 WON -14 * AA id I 001W. In o 01 04000 WH 4A VU A...qafl- *4* *AM04 N)~J- 0LAU)02m-44 ("%dco MC4 - - 20 4UWAWUU 0.4 mu P M s4. M 4. o 4m *4 PMdd * 0.4 0d ,E H 0 24 0~ 0 D2- 024I 2 * il4 *4dli*JU0W4 M Ua4

Weyerhaeuser Export Facility at DuPont. Volume III. Appendices R - T.

DTIC Science & Technology

1982-05-01

o 1 0N. u 𔃺-43-.Ell. in- All~ 4E-W -Sl >.41 03..l 0 -. 0.El El4 -0 00. ElE w wo El0 0 E.W a A44 l iV t 4 r A - - . 1 %9C 4 U. o U 10 ).- 3W 4 aQ 4...8217 , u =1 0.H, a t 0𔃺 El4 2-0.4 4 00 LI 40. -0 f.. N . .2 C 44 04 >, . 00 a 10 0 ~ 01 020 0 *. 20A 3. 40 04 .4 a,4 - 44 4 E 0 A2. U.~E4 Q 4 4.0 0 6.a

Syntheses, crystal structure, and electronic properties of the five ABaMQ{sub 4} compounds RbBaPS{sub 4}, CsBaPS{sub 4}, CsBaVS{sub 4}, RbBaVSe{sub 4}, and CsBaVSe{sub 4}

DOE Office of Scientific and Technical Information (OSTI.GOV)

Mesbah, Adel; ICSM, UMR 5257 CEA / CNRS / UM / ENSCM, Site de Marcoule-Bâtiment 426, BP 17171, 30207 Bagnols-sur-Cèze Cedex; Prakash, Jai

Five new compounds belonging to the ABaMQ{sub 4} family were synthesized by solid-state chemistry at 1123 K. The compounds RbBaPS{sub 4}, CsBaPS{sub 4}, CsBaVS{sub 4}, RbBaVSe{sub 4}, and CsBaVSe{sub 4} are isostructural and have the TlEuPS{sub 4} structure type. They crystallize in space group D{sup 16}{sub 2h} – Pnma of the orthorhombic system. Their structure consists isolated MQ{sub 4} tetrahedra separated by A and Ba atoms to form a salt-like structure. Density Functional Theory (DFT) calculations of the electronic structures with the use of the HSE functional suggest that the compounds are semiconductors with calculated band gaps of 3.3 eVmore » (RbBaPS{sub 4}), 3.4 eV (CsBaPS{sub 4}), 2.3 eV (CsBaVS{sub 4}), and 1.6 eV (RbBaVSe{sub 4}). - Graphical abstract: General view of the ABaMQ{sub 4} structure down the a axis. - Highlights: • Five new ABaMQ{sub 4} compounds were synthesized by solid-state chemistry at 1123 K. • RbBaPS{sub 4}, CsBaPS{sub 4}, CsBaVS{sub 4}, RbBaVSe{sub 4}, and CsBaVSe{sub 4} have the TlEuPS{sub 4} structure type. • The compounds are semiconductors with calculated band gaps ranging from 1.6 to 3.4 eV.« less

Collision-induced dissociation of [4Fe-4S] cubane cluster complexes: [Fe4S4Cl4 - x(SC2H5)x]2-/1- (x = 0-4)

NASA Astrophysics Data System (ADS)

Fu, You-Jun; Laskin, Julia; Wang, Lai-Sheng

2006-09-01

Collision-induced dissociation (CID) experiments on a series of [4Fe-4S] cluster ions, [Fe4S4Cl4 - x(SC2H5)x]2-/1- (x = 0-4), revealed that their fragmentation channels change with the coordination environment. Among the three Coulomb repulsion related channels for the doubly charged species, the collision induced electron detachment channel was found to become more significant from x = 0 to 4 due to the decreasing electron binding energies and the magnitude of repulsion Coulomb barrier, while both the ligand detachment of Cl- and the fission of the [Fe4S4]2+ core became more and more significant with the increase of the Cl- coordination, and eventually became the dominant channel at x = 0. From the parents containing the SC2H5 ligand, neutral losses of HSC2H5 (62 u) and/or HSCHCH2 (60 u) were observed. It was proposed that inter- and intra-ligand proton transfer could happen during the CID process, resulting in hydrogen coordination to the [4Fe-4S] cluster. In the presence of O2, [Fe4S4Cl3(SC2H5)]2- and [Fe4S4Cl4]2- can form the O2-substituted products [Fe4S4Cl2(SC2H5)O2]- and [Fe4S4Cl3O2]-, respectively. It was shown that the O2 complexation occurs by coordination to the empty iron site of the [4Fe-4S] cubane core after dissociation of one Cl- ligand.

Installation Restoration Program. Phase I. Records Search, Hazardous Materials Disposal Sites, Griffiss AFB, New York.

DTIC Science & Technology

1981-07-01

Disposal Methods 4-31 Evaluation of Past and Present Waste 4-35 Disposal Facilities Landfills 4-35 Dry Wells 4-37 Rating of Waste Disposal Sites 4-37 V 2...Problems Identified at GAPE Landfills 4-36 4.12 Priority Ranking of Potential 4-38 Contamination Sources 4.13 -4.31 Rating Forms for Waste Disposal Sites 4...39 -4-76 5.1 Priority Ranking of Potential Con- 5-2 tamination Sources B.1 Rating Factor System B-2 -B-5 4W EXECUTIVE SUMMARY The Resource

Efficacy and Mode of Action of Immune Response Modifying Compounds against Alphaviruses and Flaviviruses.

DTIC Science & Technology

1986-12-31

monophosphate (AMP) as the substrate and p-nitrophenyl phosphate as the competitive inhibitor of phosphatase activity (23). The S.A. was expressed as n...4JM -4’ nLn 0 = 0 c to V-4 u 1.-1 ( 4.40 91a,*uQ 4401- o01 V~ P: v-r4 4.4 0 u oWt Q) 4 W 0 tW4 - u4~ ccv4 - 41 0-v- 0’’.4 .o cc 0 *o 4J 44.- V0 𔃺 > * 0

Orbiting Space Debris: Dangers, Measurement and Mitigation

DTIC Science & Technology

1992-01-01

42 2.3.3 Operational Debris 43 2.3.4 Fragmentation Debris 45 2.4 Smaller Debris Sources 62 2.4.1 Paint Chips 62 2.4.2 Exhaust Particles 63 2.4.3...4.1 Velocity of Collisions 109 4.2 Damage Mechanisms 114 4.2.1 Particle Impact 117 4.2.2 Impulsive Loading 119 4.2.3 Spalling 120 4.2.4 Shock 121 4.2.5...Inclination. Size Figure 3.8 Space Command Catalog Completeness as 85 Determined with the GEODSS Telescopes Figure 3.9 Meteoriod Flux vs Particle Diameter 88

Interleukin 4 signals through two related pathways.

PubMed

Pernis, A; Witthuhn, B; Keegan, A D; Nelms, K; Garfein, E; Ihle, J N; Paul, W E; Pierce, J H; Rothman, P

1995-08-15

The interleukin 4 (IL-4) signaling pathway involves activation, by tyrosine phosphorylation, of two distinct substrates, a signal-transducing factor (STF-IL4) and the IL-4-induced phosphotyrosine substrate (4PS). It is not known whether the IL-4-mediated activation of these substrates occurs via related or distinct signaling pathways. We report that 32D cells, an IL-3-dependent myeloid progenitor cell line in which no phosphorylated 4PS is found, activate high levels of STF-IL4 in response to IL-4. Consistent with the known requirement for 4PS or insulin receptor substrate 1 (IRS-1) in IL-4-mediated mitogenesis, activation of STF-IL4 in 32D cells is not sufficient for IL-4-inducible c-myc expression. In addition, we have examined the ability of 32D cells transfected with different truncation mutants of the human IL-4 receptor to activate Jak-3 kinase and STF-IL4 in response to human IL-4. As in the case of 4PS/IRS-1, we have found that activation of both Jak-3 and STF-IL4 requires the presence of the IL-4 receptor region comprising aa 437-557. The finding that the same region of the IL-4 receptor is required for the induction of both 4PS/IRS-1 and STF-IL4 suggests that the IL-4-stimulated activation of these two substrates might involve common factors.

Mobile Sensors Environmental Assessment

DTIC Science & Technology

2005-09-26

4-1 4.1 Impacts of Land-Based Sensors.........................................................................4-1 4.1.1 Air Quality...4-27 4.3 Impacts of the Proposed Action...4-38 4.6 Cumulative Impacts

Environmental Assessment Report: Geotechnical Field Investigations.

DTIC Science & Technology

1975-06-30

ENVIRONMENTAL IMPACT OF THE PROPOSED ACTION...................148 4.1 SOCIOECONOMIC IMPACT ...................148 4.2 IMPACT ON CLIMATE.......................149...4.3 IMPACT ON AIR QUALITY.................150 4.3.1 VEHICULAR EMISSIONS....................150 4.3.2 DUST.............................150 4.4 NOISE... IMPACT .............................151 4.5 AESTHETIC IMPACT .......................152 4.6 IMPACT ON ECOLOGY...................153 4.6.1 GENERAL

Geographic List of Prime Contract Awards. Oct 92-Sep 93. FY 93. (Absarokee, Montana-Truth or Consequences, New Mexico). Part 8

DTIC Science & Technology

1994-03-01

4- wi 01 (A I- s- 4-’ (A (4 m) 5- C - U 0 0 0 U) 01 0) U) d’ I V) V) ( 1 ) < (0 4S) L C 0 4-) 4) 01 _0 0 > c a) c L 4-) S 1 . - u U C -’ S.- CD 0 C 0 C...4J fo to - i’ Ca 0 cu -n0 C C Co (a IV Q) (n ’C ’C C ) C C E in 0) M) =4 5- L M1 -. 4- I ’ 3: t l) 01 c/) U) C En a) M- 4- .i 4- C C: < -M 44 ’ 1 , . U...0L.0 0) *’- (D M > to -.- - - 0 ’C to It SC a -’ C - = C 4 C ’ E m 4- o S- Li. U 1 :4- :j 4- 4-’ E a 0) 4.- C) 0 (D -- o -’- E C/) < 0 TE >% 4-’ 0- 4

Prime Contract Awards Alphabetically by Contractor, State or Country, and Place. Part 18 (University of Virginia, Carsonville, Virginia - Zymark Corporation, Hopkinton, Massachusetts), FY1991

DTIC Science & Technology

1991-01-01

C 44 ) C4 04 444)c_ _) I LC.) InflQAQ -4 < -4 -4< a 4 c - I 0)-CI I~ 000 10) 1" W .) 0 0007 10 10 LA LAY) LADO I I aH0 HO cc.4-4r 0 n r -I0 07 nc oq 0...4 (D C) -. C-4 0 IN -, r) IN N4 I3U to 04 a c( 0v o00 E co o CL0 to0 Or. Mb" be - -0) -oIn 3 1 0 3 1.W4 00 LC L.N 1C,) ENc >-0 I-N 0.0 L 6--4 L...4N E c’ m.40704mmo7 41,07 00C 0)07 -4 W07 ENC 0 If w4 6 04 66 AS0) .=07 00o momI-4-.c) 00) 4--4.-4 -40 0(D al 064 - XN0 0)1 C6 8 I CO. H:30 00 U-4

Dollar Summary of Federal Supply Classification and Service Category by Company. Part 3 (J066-S201)

DTIC Science & Technology

1990-01-01

8217 3’ O 0 Z- I-J 0 0 Q~ ,J< ,0 0 1- 1- u. cn bJb (- Q(< - f a d a U a 0 4< I- L < I 0 0 C 4 I I 0 I- 0 Z 4 0 cc I I- LA 4) w- L - 0 IU < LU 0r C) LA 2...8217 -0 00 m00 C) In0 .4 (o V~ 4t I’. V it 000 f’t m 9 4 ,. 7 𔃾 .4 Go CS 0 4 (0 Hh I .I_ . 14 _’_-_ .4 _4 -4 .4 -4. ’ 4-4 Nt r - up In 0 In o1 l0 I A u Z...m n m - Z = "r i 9. C. ¢/1 IJ Hb 0 LL r,, (a to3. Jb u- -, 0 , I -, w 0- .,1 w- 0/ x0 4) c z- =J 0 0 0 ..4 0"Z o -1 -H ... 4 go Z Z,4 € z- CA ( y 0

A Deuterium NMR Study of Bent-Core Liquid Crystals. 1; Synthesis and Characterization of Deuterium-Labeled Oxadiazole-Containing Liquid Crystals

NASA Technical Reports Server (NTRS)

Dingemans, Theo J.; Madsen, Louis A.; Samulski, Edward T.; Bushnell, Dennis M. (Technical Monitor)

2002-01-01

We have synthesized two deuterated boomerang-shaped liquid crystals based on 2,5-bis(4-hydroxyphenyl)-1,3,4-oxadiazole (ODBP). Deuterium was introduced in the rigid 2,5-diphenyl-1,3,4-oxadiazole core and in the aromatic ring of the terminal 4-dodecyloxyphenyl moiety using standard acid catalyzed deuterium exchange conditions. Both compounds, ([4,4'(1,3,4-oxadiazole-2,5-diyl-d4)] di-4-dodecyloxybenzoate: ODBP-d4-Ph-O-C12) and ([4,4'(1,3,4-oxadiazole-2,5-diyl)] di-4-dodecyloxy-benzoate-d4; ODBP-Ph-d4-O-C12) were investigated by nuclear magnetic resonance, optical microscopy and differential scanning calorimetry. The optical textures and thermal behavior of both compounds were found to be identical to the non-deuterated analog [4,4(1,3,4-oxadiazole-2,5-diyl)] di-4-dodecyloxybenzoate (ODBP-Ph-O-C12) which we reported earlier. These compounds exhibit behavior indicative of a biaxial nematic liquid crystal phase, which we hope to confirm using deuterium NMR spectroscopy in the next phase of this study.

All Prime Contract Awards by State or Country, Place, and Contractor, FY 88. Part 14. (Aberdeen, North Carolina-Zanesville, Ohio)

DTIC Science & Technology

1988-01-01

a) > fr wUO wua w U.1 W 0 w 0C(00O-4 C 0 a. W(1 La- 0--cl - (n U, -.1 i.* .- " I,.1- wI- 44 Z(0(01- C(0.-4 l(0 w0 1-0 co 0Nz W 00 W(1-lZ Cr-Z um1 00...l N N l N 1 N N-4.-4 ’-4-4.-IN -4 1 00r- I Nl NI N1 N" -4-4 C1 "NNNli- I01( Q L I 1 -4 -4 - 4 -4 fr -- CNNN U) 100’V I I1Q000 I N N1 -4 -4 N4 N 04NN...4 .- 4 . 4 4- I 00(0 I C~ -r- I- r 0-r-r.r- fr - l P- Qr- r- or- ar- >J- >j- >,t- r- r- r- . DO(0 o ’n I4400000 40000000 1000 440 m0 m 0 mU0

Prime Contractors with Awards Over $25,000 by Name, Location, and Contract Number. Part 6. (Kenett Corporation-Mid South Dredging, Inc.)

DTIC Science & Technology

1989-01-01

o 04 - a. 4CJC zAw IL I 0.H 8 :3~~ z I0 0.DC 49 .I QE C-) w z zn 04. .. .4.4.4 . 44 ~ t .00.0c. -3 cc) C> t10 N r- OD C,-4 IZD CD - 0n 00 040 -O...U 4-4 4- - tun OD 0 m4 00 C)I C0 0 OD N0 -4t ) DO U) 4 (Ii tc CtD( -C -4 OD -DC tNkn ( IQr-O N0 c. ( z oe) 6 -r- 0) -Cjj < 0 4 4 m4 -4t 0 O m- t4 (n...r0 N n 00 L)) 0 00 0) 0 0 0 C6EuI C 40 . tun a, U - UrC 400 0% 41 4.- v1 0 )Z( 1 ,, Cli (no 0 4i W0 L- 3U 4 0 0I 0 I a. am u. U 0 0- H-I -CrU t wC0. UZ

Geographic List of Prime Contract Awards. Oct 91 - Sep 92. FY92. (San Juan California - Yale New Haven Conn)

DTIC Science & Technology

1993-01-01

414 -4-- - - 4 4 4 4 N Ř I-. I 00(0 if w0 Coto (0(0(0(000woo 0D0(((000(((0000((000(c(DW-I (0 M of4 0001 0 acca " 00 0 0 0 0 00 0 0 00 0 0 0 0 00 - 0...w l" I"r---0 InNC- (00C -.1~00oC I,-0C 0)00> f7 )(NNN,14NNNN( 1I0 o(0-4 tig>- LL- 000o - Nt ý <U- (0 in -J >(0o In4. 0y) 44 xaCp000000 CL if I(00-4...007 W10 M 1 )-4 -TM f7 - -400 "d N"t, -If N 4 40( N -4NC .4 -4040)0N0040- -ION N l 4-4 in 0 -4 ൏ NIO it xo - 0 NI0 I 0. 1 0 00 -4-4 NOCIA0 -4o N-I -4N

Dollar Summary of Federal Supply Classification and Service Category by Company. Part 4 (Y191-Z300)

DTIC Science & Technology

1991-01-01

fi W 0 ) 0 Ii IM4 1- 1 . w 𔃺 z >.4 0 z x- $. I 1-00 1-0 2 1 Z 0 "-3. 0 i I L " 02 >- 0 0 0 U) 3. 34 .w U) U) 1- 43.4 =LU fi 3.4I de x In 0 fi 1-L 2 2...0 z- w4 < 0 4 0 "a-4’ U *. I . WU) De U) w0 >0 lU t.01 z I.- I I . 6K ɞ * O a )- z Z . iU a D I Zcc Q wz > 0 U) 0 LU w2 0. NO <) < x )- x0 - VI in z...4 --4 -.4 - 4 - .4 -14 - .4 - -.4 ’. -.4 .4 . -4 4 .4 𔃾 𔃾 ’ f^a aww 0 0) 0 0D 0 0 0 W 0) 0 0) 0 0 0 a 0 0 0 U) aULa a 0 0 0 0 0 0 wL -. Zaa0 00 0 0

All Prime Contract Awards by State or Country, Place, and Contractor. Part 17 (Abbeville S. Carolina-Eldorado Texas)

DTIC Science & Technology

1990-01-01

zi-Zx a IN -4-4 1. *4-4-4-4 P~. NINI r- r- 4 0) -4 I- 11 ~w0.fp- a C 0 0 40 40000 0 000000 0 0 0 ON ofWI-4 II Z 2z Z 222 z zzzlcz2 z z z 0 .4- N 2...ISN < INN NN ɜ in 0C14 :: 0 ɜ 0 M NJ 4 N N 4I N I L0-4 C .) C , C ..0 0 0000 C0 000000 0 0 0 I U N- l ) N N NPJN N N N 44 8 0-4C40 P4 NN rN 04~0 88M c ...88, &N 0-4Ci C4 0N 00 04 0000 0 000 0 04 0 .0N C S 8 88 C Ŕ,8 4 (74 C4 0000N 4N 0000004" C44 If U C.N) N 0N J N N N N u8 8044 8 2 --- > --- >>> 𔃾

Erythrocyte and porcine intestinal glycosphingolipids recognized by F4 fimbriae of enterotoxigenic Escherichia coli.

PubMed

Coddens, Annelies; Valis, Erik; Benktander, John; Ångström, Jonas; Breimer, Michael E; Cox, Eric; Teneberg, Susann

2011-01-01

Enterotoxigenic F4-fimbriated Escherichia coli is associated with diarrheal disease in neonatal and postweaning pigs. The F4 fimbriae mediate attachment of the bacteria to the pig intestinal epithelium, enabling an efficient delivery of diarrhea-inducing enterotoxins to the target epithelial cells. There are three variants of F4 fimbriae designated F4ab, F4ac and F4ad, respectively, having different antigenic and adhesive properties. In the present study, the binding of isolated F4ab, F4ac and F4ad fimbriae, and F4ab/ac/ad-fimbriated E. coli, to glycosphingolipids from erythrocytes and from porcine small intestinal epithelium was examined, in order to get a comprehensive view of the F4-binding glycosphingolipids involved in F4-mediated hemagglutination and adhesion to the epithelial cells of porcine intestine. Specific interactions between the F4ab, F4ac and F4ad fimbriae and both acid and non-acid glycosphingolipids were obtained, and after isolation of binding-active glycosphingolipids and characterization by mass spectrometry and proton NMR, distinct carbohydrate binding patterns were defined for each fimbrial subtype. Two novel glycosphingolipids were isolated from chicken erythrocytes, and characterized as GalNAcα3GalNAcß3Galß4Glcß1Cer and GalNAcα3GalNAcß3Galß4GlcNAcß3Galß4Glcß1Cer. These two compounds, and lactosylceramide (Galß4Glcß1Cer) with phytosphingosine and hydroxy fatty acid, were recognized by all three variants of F4 fimbriae. No binding of the F4ad fimbriae or F4ad-fimbriated E. coli to the porcine intestinal glycosphingolipids occurred. However, for F4ab and F4ac two distinct binding patterns were observed. The F4ac fimbriae and the F4ac-expressing E. coli selectively bound to galactosylceramide (Galß1Cer) with sphingosine and hydroxy 24:0 fatty acid, while the porcine intestinal glycosphingolipids recognized by F4ab fimbriae and the F4ab-fimbriated bacteria were characterized as galactosylceramide, sulfatide (SO(3)-3Galß1Cer), sulf-lactosylceramide (SO(3)-3Galß4Glcß1Cer), and globotriaosylceramide (Galα4Galß4Glcß1Cer) with phytosphingosine and hydroxy 24:0 fatty acid. Finally, the F4ad fimbriae and the F4ad-fimbriated E. coli, but not the F4ab or F4ac subtypes, bound to reference gangliotriaosylceramide (GalNAcß4Galß4Glcß1Cer), gangliotetraosylceramide (Galß3GalNAcß4Galß4Glcß1Cer), isoglobotriaosylceramide (Galα3Galß4Glcß1Cer), and neolactotetraosylceramide (Galß4GlcNAcß3Galß4Glcß1Cer).

Erythrocyte and Porcine Intestinal Glycosphingolipids Recognized by F4 Fimbriae of Enterotoxigenic Escherichia coli

PubMed Central

Coddens, Annelies; Valis, Erik; Benktander, John; Ångström, Jonas; Breimer, Michael E.; Cox, Eric; Teneberg, Susann

2011-01-01

Enterotoxigenic F4-fimbriated Escherichia coli is associated with diarrheal disease in neonatal and postweaning pigs. The F4 fimbriae mediate attachment of the bacteria to the pig intestinal epithelium, enabling an efficient delivery of diarrhea-inducing enterotoxins to the target epithelial cells. There are three variants of F4 fimbriae designated F4ab, F4ac and F4ad, respectively, having different antigenic and adhesive properties. In the present study, the binding of isolated F4ab, F4ac and F4ad fimbriae, and F4ab/ac/ad-fimbriated E. coli, to glycosphingolipids from erythrocytes and from porcine small intestinal epithelium was examined, in order to get a comprehensive view of the F4-binding glycosphingolipids involved in F4-mediated hemagglutination and adhesion to the epithelial cells of porcine intestine. Specific interactions between the F4ab, F4ac and F4ad fimbriae and both acid and non-acid glycosphingolipids were obtained, and after isolation of binding-active glycosphingolipids and characterization by mass spectrometry and proton NMR, distinct carbohydrate binding patterns were defined for each fimbrial subtype. Two novel glycosphingolipids were isolated from chicken erythrocytes, and characterized as GalNAcα3GalNAcß3Galß4Glcß1Cer and GalNAcα3GalNAcß3Galß4GlcNAcß3Galß4Glcß1Cer. These two compounds, and lactosylceramide (Galß4Glcß1Cer) with phytosphingosine and hydroxy fatty acid, were recognized by all three variants of F4 fimbriae. No binding of the F4ad fimbriae or F4ad-fimbriated E. coli to the porcine intestinal glycosphingolipids occurred. However, for F4ab and F4ac two distinct binding patterns were observed. The F4ac fimbriae and the F4ac-expressing E. coli selectively bound to galactosylceramide (Galß1Cer) with sphingosine and hydroxy 24:0 fatty acid, while the porcine intestinal glycosphingolipids recognized by F4ab fimbriae and the F4ab-fimbriated bacteria were characterized as galactosylceramide, sulfatide (SO3-3Galß1Cer), sulf-lactosylceramide (SO3-3Galß4Glcß1Cer), and globotriaosylceramide (Galα4Galß4Glcß1Cer) with phytosphingosine and hydroxy 24:0 fatty acid. Finally, the F4ad fimbriae and the F4ad-fimbriated E. coli, but not the F4ab or F4ac subtypes, bound to reference gangliotriaosylceramide (GalNAcß4Galß4Glcß1Cer), gangliotetraosylceramide (Galß3GalNAcß4Galß4Glcß1Cer), isoglobotriaosylceramide (Galα3Galß4Glcß1Cer), and neolactotetraosylceramide (Galß4GlcNAcß3Galß4Glcß1Cer). PMID:21949679

Interleukin 4 signals through two related pathways.

PubMed Central

Pernis, A; Witthuhn, B; Keegan, A D; Nelms, K; Garfein, E; Ihle, J N; Paul, W E; Pierce, J H; Rothman, P

1995-01-01

The interleukin 4 (IL-4) signaling pathway involves activation, by tyrosine phosphorylation, of two distinct substrates, a signal-transducing factor (STF-IL4) and the IL-4-induced phosphotyrosine substrate (4PS). It is not known whether the IL-4-mediated activation of these substrates occurs via related or distinct signaling pathways. We report that 32D cells, an IL-3-dependent myeloid progenitor cell line in which no phosphorylated 4PS is found, activate high levels of STF-IL4 in response to IL-4. Consistent with the known requirement for 4PS or insulin receptor substrate 1 (IRS-1) in IL-4-mediated mitogenesis, activation of STF-IL4 in 32D cells is not sufficient for IL-4-inducible c-myc expression. In addition, we have examined the ability of 32D cells transfected with different truncation mutants of the human IL-4 receptor to activate Jak-3 kinase and STF-IL4 in response to human IL-4. As in the case of 4PS/IRS-1, we have found that activation of both Jak-3 and STF-IL4 requires the presence of the IL-4 receptor region comprising aa 437-557. The finding that the same region of the IL-4 receptor is required for the induction of both 4PS/IRS-1 and STF-IL4 suggests that the IL-4-stimulated activation of these two substrates might involve common factors. Images Fig. 1 Fig. 2 Fig. 3 Fig. 4 Fig. 5 Fig. 6 PMID:7544011

Work Values of Hispanic and Mainstream Navy Recruits.

DTIC Science & Technology

1982-03-01

E . aniel. C hmnain IL 61820 ..... ._- _ 1CONTROLI ING OPPIC4 NAME AND ADDRESS IL REPOT OATS Organizational Effectiveness Research-Group Office of...to . 4-4*- 0 e 2$ 0 do to o .0 S!* 0o 0:0 0- UlC) 0. 44 . tOt 4f4) V- j t P4 2 03 094 00 0 1 -0 j C X N :1 g.0.0 4𔃾 CD 03 0 0 to 0 00 03 12 vi t0... c r .4~ H . . %% 0 0 r . 4-1 to~ q. 4) t 0O) to to > "A 1 t U) 4~ ’ -% ~ Ze lo ~ A 4J136 0 . 0) 0) . w - 4 0 4J~ to0 4.) 0. 0 z z t4 C .

Department of Defense Prime Contract Awards Over $25,000 by Weapon System, Contractor and Work Performed. Fiscal Year 1993. (AAA Navy A-1 Skyraider-SMR Navy Harbor IGE YTB)

DTIC Science & Technology

1994-03-01

ui ac < 10 Z BPP - ft ~ F.UB O 00)-m BGBBN Cr (0jW-4 () 0 NO 000-4 C4 r)NB 4 V V ~C% O : 0 B . C)O:M-4 WO GONO=O -4 NC’)c)(0-V B N M0.-4 MMMOCr-MM~ M...0 L. CW 0 ) - L-a L.C a4*.4 CUOI Q, O. C I.-4 Co. E 4on _1 ’ 4 L. 1.C C- E.4 -041-- E.4 U U. 0 C I I 0 4 W; C C. X - ..41- 5. in C &I.U 5L. L Sbl W4

Effect of solvent on the electronic absorption spectral properties of some mixed β-octasubstituted Zn(II)-tetraphenylporphyrins

NASA Astrophysics Data System (ADS)

Bhyrappa, P.; Sankar, M.

2018-01-01

A series of mixed β-octasubstituted Zn(II)-porphyrins, 2,3,12,13-tetra(chloro/cyano/methyl)-5,7,8,10,15,17,18,20-octaphenylporphinato zinc(II), ZnTPP(Ph)4X4 (X = CN, Cl and CH3) have been examined by electronic absorption spectroscopy in various solvents. These Zn(II)-porphyrins exhibited varying degree of red-shift of absorption bands as high as 20-30 nm in 'B' band and 50-60 nm in longest wavelength band, 'Q(0,0)' band in polar solvents relative to that found in nonpolar solvents. The red-shift of B and Q(0,0) bands showed an unusual trend, ZnTPP(Ph)4(CN)4 > ZnTPP(Ph)4(CH3)4 > ZnTPP(Ph)4Cl4 but fails to follow an anticipated anodic shift in first porphyrin ring oxidation (vs Ag/AgCl) potential: ZnTPP(Ph)4(CN)4 (1.02 V) > ZnTPP(Ph)4Cl4 (0.74 V) > ZnTPP(Ph)4(CH3)4 (0.38 V). Such a trend suggests the combined effect of non-planarity of the macrocycle and electronic effect of the peripheral substituents. The equilibrium constants for the binding of nitrogenous bases with the Zn(II)-porphyrins showed as high as twenty fold increase for ZnTPP(Ph)4X4 (X = Br and CN) relative to ZnTPP(Ph)4(CH3)4 and follow the order: ZnTPP(Ph)4(CN)4 > ZnTPP(Ph)4Br4 > ZnTPP(Ph)4(CH3)4 ≤ ZnTPP which is approximately in line with an increase in anodic shift of their first ring redox potentials (ZnTPP(Ph)4(CN)4 (1.02 V) > ZnTPP(Ph)4Br4 (0.72 V) > ZnTPP (0.84 V) > ZnTPP(Ph)4(CH3)4) (0.38 V).

Protective Role of Acidic pH-Activated Chloride Channel in Severe Acidosis-Induced Contraction from the Aorta of Spontaneously Hypertensive Rats

PubMed Central

Ma, Zhiyong; Qi, Jia; Fu, Zhijie; Ling, Mingying; Li, Li; Zhang, Yun

2013-01-01

Severe acidic pH-activated chloride channel (ICl,acid) has been found in various mammalian cells. In the present study, we investigate whether this channel participates in reactions of the thoracic aorta to severe acidosis and whether it plays a role in hypertension. We measured isometric contraction in thoracic aorta rings from spontaneously hypertensive rats (SHRs) and normotensive Wistar rats. Severe acidosis induced contractions of both endothelium-intact and -denuded thoracic aorta rings. In Wistar rats, contractions did not differ at pH 6.4, 5.4 and 4.4. However, in SHRs, contractions were higher at pH 5.4 or 4.4 than pH 6.4, with no difference between contractions at pH 5.4 and 4.4. Nifedipine, ICl,acid blockers 5-nitro-2-(3-phenylpropylamino) benzoic acid (NPPB) and 4,4′-diisothiocyanatostilbene-2, 2′-disulfonic acid (DIDS) inhibited severe acidosis-induced contraction of aortas at different pH levels. When blocking ICl,acid, the remnant contraction was greater at pH 4.4 than pH 5.4 and 6.4 for both SHRs and Wistar rats. With nifedipine, the remnant contraction was greatly reduced at pH 4.4 as compared with at pH 6.4 and 5.4. With NPPB or DIDS, the ratio of remnant contractions at pH 4.4 and 5.4 (R4.4/5.4) was lower for SHRs than Wistar rats (all <1). However, with nifedipine, the R4.4/5.4 was higher for SHRs than Wistar rats (both >1). Furthermore, patch clamp recordings of ICl,acid and intracellular Ca2+ measurements in smooth muscle cells confirmed these findings. ICl,acid may protect arteries against excess vasoconstriction under extremely acidic extracellular conditions. This protective effect may be decreased in hypertension. PMID:23580361

Solid Waste Management in Marine Amphibious Force (MAF) Operations: Analysis and Alternatives.

DTIC Science & Technology

1980-09-01

Experience during the Southeast Asia conflict and elsewhere shows that MAF solid waste management requires a significant deployment of manpower and equipment...MAF varies, by necessity, with the location or type of military action. Based in part on recent experience gained in the Southeast Asia conflict, a...4 1- r 410 0 0 MCD %4 0. 0 0> 0 0 0.Z5 -4 4r44. ,4-14 1 cc U 44 UCI 4 4 0 -401. 4 0 0 U2fl󈧺 $ICɜ 41 *4 0J 4)% 4 4) u ~ .)ails- ii , )4 -4 to 40 be

Universal Virus Adsorption on Inert Particles Utilizing the Coated Latex Adsorption Method (CLAM)

DTIC Science & Technology

1975-06-30

identification of such adsorbents as bacteria, bacteria-specific antibodies, hormones, enzymes , nucleic acids, toxins, and lipids. Any carrier particle which...hormones, anti- bodies, cellular constituents, enzymes , etc. Also particles other than latex may be employed in the method providing they are uniform in...Ha .14 4 V4 1-4 :31 10 0 U -4 w -4 4 00 0 0 4) 44-4 226 m 0 1 £0 I PO r4 -- 7ý -7 00 C)) + 0 -J .-4 o - H X 0 toII coQ -4 4J ,9rl 0 4- p 4- 0) C: 12 +0

All Prime Contract Awards by State or Country, Place, and Contractor, FY 87. Part 21. Aberdeen, Washington-Classified Location, Domestic.

DTIC Science & Technology

1987-01-01

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Prime Contract Awards Alphabetically by Contractor, State or Country, and Place. Part 7 (Federal Improvement Co Inc, Virginia Beach, Virginia - Giordano Associates Inc, Robins AFB, Georgia), FY1991

DTIC Science & Technology

1991-01-01

CN 040 cOm 0 1- 00 ɘ 5.00 X0 w 1- Imn w* a 0 6 004 x -.400 N - ery 4N 0t I-NC .7-4 540 0. -m 0 C a0 n is CA IS I (0(04 If so* AO .flmfl -3115 EC) 4...0 0 0 0 0, 0 0D 0 o 0 W CU .- 00 Cm, .0m .0m .0m GoaM com caM c0m 00am cam Mcam ccaM S4W I -1 .4c P.4 l 1-4 ’ .4 <.. r.4x r -C4 r.4c r. 4 r_< . < I...x X NNX XNxX X XN X N NN W * )4.O I 0~ C7 D c aCD 200 0CDCD (9 00 10 5 5 ( 0(9 (90 D 0CDCD 9 (D(5(D D C90 ) 0C90 ( C * 0 qo U 4 4 44 4 4 4 44 4 4 4

Effect of disulfide bonding and multimerization on proteoglycan 4's cartilage boundary lubricating ability and adsorption.

PubMed

Abubacker, Saleem; Ponjevic, Dragana; Ham, Hyun O; Messersmith, Phillip B; Matyas, John R; Schmidt, Tannin A

2016-01-01

The objectives of this study were to assess the cartilage boundary lubricating ability of (1) nonreduced (NR) disulfide-bonded proteoglycan 4 (PRG4) multimers versus PRG4 monomers and (2) NR versus reduced and alkylated (R/A) PRG4 monomers and to assess (3) the ability of NR PRG4 multimers versus monomers to adsorb to an articular cartilage surface. PRG4 was separated into two preparations, PRG4 multimer enriched (PRG4Multi+) and PRG4 multimer deficient (PRG4Multi-), using size exclusion chromatography (SEC) and characterized by sodium dodecyl sulfate polyacrylamide gel electrophoresis (SDS-PAGE). The cartilage boundary lubricating ability of PRG4Multi+ and PRG4Multi- was compared at a physiological concentration (450 μg/mL) and assessed over a range of concentrations (45, 150, and 450 μg/mL). R/A and NR PRG4Multi- were evaluated at 450 μg/mL. Immunohistochemistry with anti-PRG4 antibody 4D6 was performed to visualize the adsorption of PRG4 preparations to the surface of articular cartilage explants. Separation into enriched populations of PRG4Multi+ and PRG4Multi- was achieved using SEC and was confirmed by SDS-PAGE. PRG4Multi+ and PRG4Multi- both functioned as effective friction-reducing cartilage boundary lubricants at 450 μg/mL, with PRG4Multi+ being more effective than PRG4Multi-. PRG4Multi+ lubricated in a dose-dependent manner, however, PRG4Multi- did not. R/A PRG4Multi- lubricated similar to NR PRG4Multi-. PRG4-containing solutions showed 4D6 immunoreactivity at the articular surface; the immunoreactive intensity of PRG4Multi+ appeared to be similar to SF, whereas PRG4Multi- appeared to have less intensity. These results demonstrate that the intermolecular disulfide-bonded multimeric structure of PRG4 is important for its ability to adsorb to a cartilage surface and function as a boundary lubricant. These findings contribute to a greater understanding of the molecular basis of cartilage boundary lubrication of PRG4. Elucidating the PRG4 structure-lubrication function relationship will further contribute to the understanding of PRG4's role in diarthrodial joint homeostasis and disease.

Fabrication of water-soluble polymer-encapsulated As4S4 to increase oral bioavailability and chemotherapeutic efficacy in AML mice

PubMed Central

Ma, Qiang; Wang, Chuan; Li, Xiaojin; Guo, Hua; Meng, Jie; Liu, Jian; Xu, Haiyan

2016-01-01

Realgar (As4S4) has been demonstrated to be effective for the treatment of acute myeloid leukemia (AML); it has the advantages of no drug resistance and oral administration. Nevertheless, its poor solubility has been an obstacle to its bioavailability, requiring high-dose administration over a long period. We investigated whether crushing realgar crystals to the nanoscale and encapsulating the particles in a water-soluble polymer in one step using hot-melt extrusion would increase the bioavailability of As4S4. Raw As4S4 (r-As4S4) and water-soluble polymer were processed via co-rotating twin screw extrusion. The resulting product (e-As4S4) was characterized by SEM, XRD, and DLS. The cytotoxicity and therapeutic effects of e-As4S4 were evaluated in vivo and in vitro. The results show that e-As4S4 dissolved rapidly in water, forming a stable colloid solution. The average size of e-As4S4 particles was 680 nm, which was reduced by more than 40-fold compared with that of r-As4S4. The bioavailability of e-As4S4 was up to 12.6-fold higher than that of r-As4S4, and it inhibited the proliferation of HL-60 cells much more effectively than did r-As4S4, inducing apoptosis and significantly reducing the infiltration of HL-60 cells into the bone marrow, spleen, and liver. This in turn prolonged the survival of AML mice. PMID:27383126

Development of Structure and Properties of 7050 and 7475 Alloys During Direct Extrusion

DTIC Science & Technology

1981-06-01

0r4~ 0r4C ~ -4T In %D r’. co r-4 -r--4 .4-4v---4 4 N Cq C%14 NN r4 cococ cococ ON oc mooc ONmocoN G * ~ ~ It~c -t~a 4~’o o𔃾o-t co *Ir-4 rr Dý ~~-t 0...Schey Philadephia, PA 91901 Department of Materials Engineering Attn: Technical Library University of Illinois at Chicago Circle Box 4348 Chicago, IL

Maintenance Dredging of the Federal Navigation Channels in the St. Clair River, Michigan.

DTIC Science & Technology

1976-01-01

Detroit livers system today constitutes a major corridor for waterborne traffic, and therefore a central axis of settlement, it should not be surprising...0 C;U2 $4 2) ~ 4 .0 41 -4 0~ 0~ ~0 -4 144 .H ,.4ul0. ".4 -4 -4 4.42 0 0 4.44 -44 ’U r rU 0 54 4-’ 4 .14 1- 1 A N.~~- A. )0 > TABLE 14. Wildife in

Remote Sensing Technologies and Spatial Data Applications.

DTIC Science & Technology

1987-12-01

multispectral or thermal infrared techniques. Radar (active) or passive microwave data may strongly assist because of the "relatively" unique emissivity ...UW w 00 4w 0. C:’- " Oh C -4 cd 04 : w -0 *4 v o 0 4 H J r4 "I Uw 0 0 uJ 04) hI u u 93d b e 4 04) 00., 4).- - HHO " 0 𔃺 UO 014 -4 W 4)4 U -4 0d O P-4P

77 FR 10409 - Airworthiness Directives; Airbus Airplanes

Federal Register 2010, 2011, 2012, 2013, 2014

2012-02-22

...; Model A310 series airplanes; Model A300 B4-600, B4-600R, and F4-600R series airplanes, and Model C4-605R... Model A300 B4-603, B4-620, and B4-622 airplanes, Model A300 B4-605R and B4-622R airplanes, Model A300 F4-605R and F4- 622R airplanes, and Model A300 C4-605R Variant F airplanes. (d) Subject Air Transport...

The Air Force Manual for Design and Analysis of Hardened Structures

DTIC Science & Technology

1974-10-01

PHOTOGRAPH THIS SHEET 71H(Z7 FO IC-~ M A AluA4 Fe 41, 00 Ai -A. 55 0LEVEL INVENTORY Lf) DOCUMENT IDENTIFICATION ~UIMON STRTEMENT A Approvd for public...aU0 t SiE =~ E.4 04 5 0U U . 5 44 N A-4 o. 0- 4 A) (4 0 0 el 0% 0> -0 04 00 ’. 0 0 t0 0* (4 Aj 0 0 .4 4 A5 b4 .4 aN 55 k U CH W VVo 01 M M M M M M M...0 𔃿 40. 0%. u) a 0 a 14) "j0-4Aj% w L 0. 4 ao 4) ’a :.~ -c 1jŔ 14 04 1 0 ) t404 04) 4: U3 0 0444) -.4 0.’ 55 10 u4 - 0 4) 1. ) c) U .C. U 0~ 0 w 0

Automating the AFROTC Four-Year Scholarship Program.

DTIC Science & Technology

1986-04-01

ATCH 2 b1 C -d C4 4" %C N 0" cl4 es C4 CN 1 onin %DG C1 06 0 -0 40 V 44-4 LIU-4- c4 A: U. -4 La 4 E vt a-’ iv El "l 04 0 0.I t b U El 4 V do v 0 CoU. -4...CEEB CLAS~S BOARD 1ST 2ND DCF QEP/ STRT,"’ HWFADC CfI3; PEL SCORES SCORE COMP SCOPE STAND RAMK".,H~DC ’ PREF PREF RACE PREY" rTL B1 = 46/1 C hiroms...A/N 88 Fencing 4 AIN 89 La Crosse 4 AIN 90 Rifle/Pistol 4 AIN 91 Rugby 4 AIN 92 Track 4 A/N 93 Wrestling 4 A/N 94 Others (Name and Codes) 15 A/N 95

Directory of Wetland Plant Vendors

DTIC Science & Technology

1992-11-01

used for advertising , publication, or promotional purposes. Citation of vendors does not constitute an official endorsement or approval of the vendor...1 u 35 I Ai * aU SO a 4 azI ofc0a003 k vi. vID v. vs . .v 1r Z, Xa D N 1 0 0 1 a~ 0 1 o ac4~ 13 -6 0 6 00ý 0~- vI *4v-4f b’U1~ ")0 v-IFA r.00 0 0 00...v4 10-W11 -W - D 40% 0- - 0- mO 0 I : at 0’ VS - 1 .4 a A 00 u- 0. 0 4j 0 -i I14 k U V *4A-4 -4 A ~4j .0 .-4 0 4 41 U0O 4 0 *o4 Sa. jI -4 C .4 0 44Ja

Information Management 70XX Civilian Equivalent

DTIC Science & Technology

1991-06-01

METHODOLOGY Data for this survey were collected using the USAF Job Inventory AFPT 90-70X-877 dated August 1989. Military specific or outdated tasks were...ce N: "!0 - 0- .4 x .V X 4 x .11 X I 4 N 10󈧎-14 aO M0I o % ci 4P W)-4 4z COZ 0 H ..J go w01 on Hu on I a I I I 1 6 M 100’’ CL. 0 A0C 0 u w .4 0 Z 1...4 -) 4)d) 0) ()0) 4)0() a) a) ) 0)0)w00 0 0 0 u H 0 4 4$ZP P-4 4P S 4W C0 CDH CD : lD )C 0 Cl 0 C \\Z t 00 00 -4 0000 0 00 D co C--1 C C14 -4 I - C14

4,2':6',4"- and 3,2':6',3"-Terpyridines: The Conflict between Well-Defined Vectorial Properties and Serendipity in the Assembly of 1D-, 2D- and 3D-Architectures.

PubMed

Klein, Y Maximilian; Prescimone, Alessandro; Constable, Edwin C; Housecroft, Catherine E

2017-06-30

A comparative investigation of the coordination assemblies formed between Co(NCS)₂ and two monotopic 4,2':6',4''-terpyridine (4,2':6',4"-tpy) ligands or two related ditopic ligands is reported. Crystals were grown by layering MeOH solutions of Co(NCS)₂ over a CHCl₃ or 1,2-C₆H₄Cl₂ solution of the respective ligand at room temperature. With 4'-(2-methylpyrimidin-5-yl)-4,2':6',4"-terpyridine ( 6 ), the 1D-coordination polymer {[Co₂(NCS)₄(MeOH)₄( 6 )₂]∙2MeOH∙8H₂O} n assembles with 6 coordinating only through the outer N-donors of the 4,2':6',4"-tpy unit; coordination by the MeOH solvent blocks two cobalt coordination sites preventing propagation in a higher-dimensional network. A combination of Co(NCS)₂ and 1-(4,2':6',4"-terpyridin-4'-yl)ferrocene ( 7 ) leads to {[Co(NCS)₂( 7 )₂]∙4CHCl₃} n which contains a (4,4) net; the 2D-sheets associate through π-stacking interactions between ferrocenyl and pyridyl units. A 3D-framework is achieved through use of the ditopic ligand 1,4-bis( n propoxy)-2,5-bis(4,2':6',4"-terpyridin-4'-yl)benzene ( 8 ) which acts as a 4-connecting node in {[Co(NCS)₂( 8 )₂] . 2C₆H₄Cl₂} n ; the combination of metal and ligand planar 4-connecting nodes results in a {6⁵.8} cds net. For a comparison with the coordinating abilities of the previously reported 1,4-bis( n octoxy)-2,5-bis(4,2':6',4"-terpyridin-4'-yl)benzene ( 3 ), a more flexible analogue 9 was prepared. {[Co(NCS)₂( 9 )]∙2CHCl₃} n contains a (4,4) net defined by both metal and ligand planar 4-connecting nodes. The n octoxy tails of 9 protrude from each side of the (4,4) net and thread through adjacent sheets; the arene-attached n octoxy chains associate through a combination of van der Waals and C-H...π interactions.

Department of Transportation Data Communications Requirements Analysis.

DTIC Science & Technology

1981-07-01

National Technical Information Service, Springfield, Virginia 22161. CJ0 us Department of Transportation FdeWAtcMk Adl*lt,. and Systems Research...General Administrative System . .. ................. 4.4 4.1.3 Coast Guard Administrative System . .. ............... 4.6 4.1.4 Transportation Automated...Office System .. .. ............ 4.6 4.1.5 OST Data Transmission Characteristics .. .. ............. 4.6 4.1.6 OST Data Communications

Final Report of the West Point Study Group

DTIC Science & Technology

1977-07-27

4 ~ CL(~ 00 -44 U6 41 M 0 014 cc in.0 531 Figre6 140 ’.44 0 0 * 0 4 , ’- 4 000 43 1 ’-. 4 ŗo- ’ 4 ’U 4 :k - 4 -0 1.4 P, t p w cc 04 0 0 43 En U3r. 8 - > 0 cd... 4 1- 4 a Lj 43 .3~~ 4 u340 w~ 8 04 Wý’. 0 V ’.44 CL .4l. -E" 4 3i-a" ,~W04 CL 8 . wiu r. -M a 0 - 4 -454 a r-Fi> co 2 0 p co;5 c o 0 w :3 0 c0 0 M- 4 a V...l1

Prime Contract Awards Over $25,000 by Major System, Contractor and State. Part 2. (BSH-SMR)

DTIC Science & Technology

1989-01-01

tI CI 4) 0 w- - 4~4 C -*. nowO )-4o -040 0 OL*l (M m 100m-1-1v-qmm 00L -t(M- 04-X 4nII W- --4Ww .nw -. 4-.M -- 4WC W-4LA -4 0QW U C W 40Ř 0-* W...L AL 0 0. J 2W -4~ 00 00L37 00 00 0U 00: 0v a0 0 04 0A < ) - 347 =N- -440 C’ ) .rN- . )-4 ~4 -4l C) M - 0 0(I) -IL.I0 Lb f 0UC0 C’ 03 U7-t0U -4N U

Worldwide U.S. Active Duty Military Deaths Alphabetical Index by Name. October 1, 1979 through September 30 1992

DTIC Science & Technology

1992-09-30

j 4 c. ZW )---)Z oo zJ ɘ nowo <o L):z E UA caw Z >-4 0 LL o 04a 44) ) 0 040 .x W U, uJl 0 L-a U.. - CL..- OL . 1.- - > Q V U-> L- C QC M >,u o~~ ~ u...34w zx > CL ww 03- O 4 a-4 4 0 ZL i4-4 347 -C 00 < M 30 W > 00 4 wC4C ’t O-l4( La. C ex -4 r- z-4 1- m CL > >0CL> CL.-4 > .-- 4 0.) M - u 4~~~~~~U 0 410

In vivo construction of a hybrid pathway for metabolism of 4-nitrotoluene in Pseudomonas fluorescens.

PubMed Central

Michán, C; Delgado, A; Haïdour, A; Lucchesi, G; Ramos, J L

1997-01-01

Pseudomonas fluorescens 410PR grows on 4-nitrobenzoate but does not metabolize 4-nitrotoluene. The TOL pWW0 delta pm plasmid converts 4-nitrotoluene into 4-nitrobenzoate through its upper pathway, but it does not metabolize 4-nitrobenzoate. P. fluorescens 410PR(pWW0 delta pm) transconjugants were isolated and found to be able to grow on 4-nitrotoluene. This phenotype was stable after growth for at least 300 generations without any selective pressure. P. fluorescens 410PR(pWW0 delta pm) converted 4-nitrotoluene into 4-nitrobenzoate via 4-nitrobenzylalcohol and 4-nitrobenzaldehyde. 4-Nitrobenzoate was metabolized via 4-hydroxylaminobenzoate and finally yielded NH4+ and 3,4-dihydroxybenzoate, which was mineralized. PMID:9139924

Transcriptional Analysis of Four Family 4 P450s in a Puerto Rico Strain of Aedes aegypti (Diptera: Culicidae) Compared With an Orlando Strain and Their Possible Functional Roles in Permethrin Resistance

DTIC Science & Technology

2014-05-01

melanogaster expressing CYP4D24, CYP4H29, CYP4J15v1, and CYP4H33 had a survival rate of 60.0 6.7, 29.0 4.4, 64.4 9.7, and 11.0 4.4...CYP4D24 and CYP4H29 had a survival rate of 37.8 4.4 and 2.2 2.2%, respectively. Taken together, our results suggest that CYP4D24 might play an...mechanisms, including target site insensitivity, reduced penetration rate , and met- abolic detoxiÞcation. In the case of metabolic detox- iÞcation

A{sub 5}RE{sub 4}X[TO{sub 4}]{sub 4} crystal growth: Fluoride flux synthesis of Na{sub 5}Ln{sub 4}F[GeO{sub 4}]{sub 4} (Ln=Pr, Nd), the first quaternary germanate oxyfluorides

DOE Office of Scientific and Technical Information (OSTI.GOV)

Latshaw, Allison M.; Wilkins, Branford O.; Morrison, Gregory

Crystals of Na{sub 5}Pr{sub 4}F[GeO{sub 4}]{sub 4} and Na{sub 5}Nd{sub 4}F[GeO{sub 4}]{sub 4} were synthesized using a eutectic sodium fluoride, sodium chloride flux. Both compounds crystallize in the tetragonal space group I-4 with lattice parameters of a=12.1173(4) Å and c=5.6795(2) Å (Pr) and of a=12.0642(17) Å and c=5.6674(11) Å (Nd). The structure of the reported compounds is three-dimensional with face and corner sharing lanthanide polyhedra which edge and corner share with isolated germanium tetrahedra. These novel compositions represent the first example of quaternary germanium containing oxyfluorides. - Graphical abstract: Structural image of the first examples of quaternary germanate oxyfluorides. Displaymore » Omitted - Highlights: • Molten flux growth of crystals of two lanthanide germanate oxyfluorides. • Expansion of the A{sub 5}RE{sub 4}X[TO{sub 4}]{sub 4} family into germanate oxyfluorides. • Synthesis of Na{sub 5}Nd{sub 4}F[GeO{sub 4}]{sub 4} and Na{sub 5}Pr{sub 4}F[GeO{sub 4}]{sub 4}.« less

Microcomputer Based Ship-Board Gun Control System.

DTIC Science & Technology

1981-03-01

to0 CD 04 5. 6D3. bi t0 U3 3 3. A - a U3 vi4 . * ~ ~ ~ 1 z.. n . 0 4 OR *4 AnS 94 C.) 0 3 * 04 td ) . cu 4. P* 0r * 3 6* 04 to 0 f 3. 4 6-4 "a I c *0...0I td ..M U o -Oq I Z ) OM Pm , N ou POO 0 -4 I h 4 * W33 SVil lot I 4- ad2 13 41 *f 0 44 ac ci 0 IH 4n 0= U 04 o3 0, 3a V). cav% n oft af 44 0 A4A... td ) -zl- ~ 6N 0 l 4 44L CdP 9 ~CI (n l 4 t3 0. .4 vi~ n - 4 U :A -. c 14 w i cn v - V", v- C) 4A " =- " cL c. Ni 0.4 (n Z m a -I 11) Cd E4 r a. a

All Prime Contract Awards by State or Country, Place, and Contractor, FY 88. Part 19. (Abington, Virginia - Yorktown, Virginia)

DTIC Science & Technology

1988-01-01

00( z Q I 40(1 I (0 C-1 (0 N-Np- -4 0) 11- (D(D (D LA Ln Ln m (n (70 -4 0) (D 044ɘ (1 10)N( 4AC 000 -4N- -.0 LADO C OOOONNNNOOOO q*0C0 400 W440(1Or...I4CD-4 0 I - ENC -4N CI I -INr~ .- ENNN "’-4NN4C1 -- ENC -4 1N cl -EN .4NC4 N 4 40M0O) I >NC >NN4 >NC’ >NNN S >NN, >N" >NC >NC >N4C > 4N I40000004 0 00 0...LI-00COW0 W I mocli IZOOOOOOOOOOOOUWIAOOO eNc - oco - ɘ wooocw - 0 CL I MON l0OOOOOOOOOOOmz u)O - -u -4 L) CL C) wzzzzmu I MO-4 1 1-1 < < 1-1 < < z

AFOSR Technical Report Summaries

DTIC Science & Technology

1992-01-01

411 91i C 1 in A . - 2 Ko 49 0U UA -in in4 4. Iz ha -a h-04- OW-4- 1-40 4. KZ4 2 0 h*4c 4 =. U. a. N I Ow us ’u I.-JAA4II A-I m. ’A Z uU 001 C4Cz ha c...1. 7 a.~ ~~~ 4’ E .. omS U U *C I 4’K S 400 1. CIL 00 KO - 4a a ~ - r 00, 4’( U Il 70 w .L H - 1. up -W AM a 0 L e KUC 0 C MW W W XK 40 W t 1 W .; 0 a...80Z .. i CCL0I 0 .6 4L= 9 : 2 T o5m 0 .4 * .4 0w0.dU a.- Mi aLM-9 t4.ZhSL pq - dal 96 0I 1-(AN # U. -v4cg - u s * 2 *IZO SKO M.IW ONOSM .W~ .-C A

AFOSR Technical Report Summaries

DTIC Science & Technology

1989-09-01

A)m 41CI- z) 3 0 -L M W ) 4- 4’ CL i0 .C4j tD 030 a - 10.C LU)I 4- -- L 00 (a -03 533 m) m0 O JL NI Cz( . 203 0 03 u4 0 02 E - 4, CL L 1 % 4 034 0 m...8217 04% UC >( L 0. I M 1 0- 0. L 0 L - ~C 4 0 4 1 W L4 -001 - CM 1 u-E22E e (U O~0U. ’-03; - >0 t a CC L0 C) - tD L" - I& 0 (U IA -4 L 0(Z4UOCCC;E - 04...Lu 0 z r U. (D~ 0 4) D- C " > C4, 3 4 (a , ( CF L 3: 41 (A 14 MCL- - 3UV ) L-44.’U C > > O 0 0- -.oA LL 0 C =W C 0CC- -C W JV M CU 4’ (A <Z V (A 4) > 4 Z

Prime Contract Awards Alphabetically by Contractor, by State or Country, and Place, FY 85. Part 20 (Tokkey Uluslarararasi Naklejet - Video & Sealing Inc).

DTIC Science & Technology

1985-01-01

ON 0- -1r)- 04 N00O 1(0 1-4 -#.-44 nO P4I 4 N 04 0 4 -1-4C M’ 281 0 11. u. cc =ta0 ’ 4 m 1004 ANl.(( 0 -O -t3- 0 UN W 0( I ce I- .40 -4 -4 1-4 14 0000...000000 00 00 000 4- I IO NCVI 1 00 I J (SN - -l4 ICNCJ .. to I ZWI In I I xo.( -1i ouooooooooooooooooooooooooooooooooooooooooooooo W -04 0 to N N990= = ao...Y C)N A 0 -4 04 - 4 4- .4 0A l -00 , 4c (00 I gn S ) 01- 1-- U)-0cccn- 0n 40n N NN -4 N (INN C, in4Uan- z CD-q z zwi I (00j I C 0) -z -C’ NV 00ltet

Jahn-Teller effect on the [TiF 4F 4F int] 6-(C 4v) and [NiF 4F 4F int] 7-(C 4v) clusters embedded into SrF 2 crystals

NASA Astrophysics Data System (ADS)

Ulanov, V. A.; Zhiteitcev, E. R.; Varlamov, A. G.

2007-07-01

By means of EPR method the associative [TiF 4F 4F int] 6-(C 4v) and [NiF 4F 4F int] 7-(C 4v) centers were revealed in the fluorite type SrF 2:Ti and SrF 2:Ni crystals grown by Bridgman method in helium atmosphere containing some amount of a fluorine gas. It was found that at low temperatures the local structures of these associative centers were exposed to a static rhombic distortion. The reasons of such distortions were accounted for by the assumption that the E ⊗ ( b1 + b2) vibronic interaction became effective due to that the ground orbital states of the [TiF 4F 4F int] 6-(C 4v) and [NiF 4F 4F int] 7-(C 4v) centers occurred to be doubly degenerated.

Takhli AB, Thailand. Revised Uniform Summary of Surface Weather Observations (RUSSWO). Parts A-F

DTIC Science & Technology

1971-04-06

DIR SPEED N .4 ISO 4_1 NNE t02 j t 6 4 : ENE ,A’ 2 to ,_1 _, ESE ,6 .5 .4. 1,4 4,4SE 2, z 6 .8 .0o I- , 5 SSE 5,4 7,7- 2,S al .. . 16,1 4,6S: 6,s8...ENE 1,6 I’s IsO &1 4,2 4091 E 2,g 9.9 1_ _ _ ESE , 0 2 1 SE a .9 ,2 ao__ 4#3 SSE a a- ______ 2,0 4 3. 2’s .0 2,1 . 1 0 0 4,9 4,4 SSW 1 .4 .6 .11 .1...6, 9, WNW 2 A . 2 ISO 4 a$ NW .2 6 III ... . 6 NNW ]-* o all ., 2 6 3 4 9 7 V~in1, 24, 1. q 1 1 T O T A L N U M BE R O F O B S E R V A T

Characterization and synthesis of volatile compounds from the defensive secretions of some "daddy longlets" (Arachnida: Opiliones: Leiobunum spp.).

PubMed

Jones, T H; Meinwald, J; Hicks, K; Eisner, T

1977-02-01

Analyses of the chief volatile constituents of the defensive secretions of three oplionids were carried out. Leiobunum nigripalpi produces three closely related C7 compounds: E-4-methyl-4-hexen-3-one(I), 4-methylhexan-3-one(II), and 4-methylhexan-3-ol(III), along with E-4-methyl-4-hepten-3-one(IV), E,E-2,4-dimethylhexa-2,4-dienal(IX), and a minor, unidentified component. L. leiopenis secretion contains E-4-methyl-4-hepten-3-one(IV), 4-methylheptan-3-one(V), E,E-2,4-dimethylhexa-2,4-dien-1-ol(VII), and E,E-2,4-dimethylhepta-2,4-dien-1-ol(VIII). L. calcar yields chiefly E-4,6-dimethyl-6-octen-3-one(VI) and E,E-2,4-dimethylhexa-2,4-dien-1-ol(VII). Six of these compounds are new natural products. The structures of these compounds, which can be regarded either as polyketide-derived or as modified isoprenoids, raise interesting biosynthetic questions.

Characterization and synthesis of volatile compounds from the defensive secretions of some "daddy longlets" (Arachnida: Opiliones: Leiobunum spp.).

PubMed Central

Jones, T H; Meinwald, J; Hicks, K; Eisner, T

1977-01-01

Analyses of the chief volatile constituents of the defensive secretions of three oplionids were carried out. Leiobunum nigripalpi produces three closely related C7 compounds: E-4-methyl-4-hexen-3-one(I), 4-methylhexan-3-one(II), and 4-methylhexan-3-ol(III), along with E-4-methyl-4-hepten-3-one(IV), E,E-2,4-dimethylhexa-2,4-dienal(IX), and a minor, unidentified component. L. leiopenis secretion contains E-4-methyl-4-hepten-3-one(IV), 4-methylheptan-3-one(V), E,E-2,4-dimethylhexa-2,4-dien-1-ol(VII), and E,E-2,4-dimethylhepta-2,4-dien-1-ol(VIII). L. calcar yields chiefly E-4,6-dimethyl-6-octen-3-one(VI) and E,E-2,4-dimethylhexa-2,4-dien-1-ol(VII). Six of these compounds are new natural products. The structures of these compounds, which can be regarded either as polyketide-derived or as modified isoprenoids, raise interesting biosynthetic questions. PMID:265514

Anhydrous versus hydrated N4-substituted 1H-pyrazolo[3,4-d]pyrimidine-4,6-diamines: hydrogen bonding in two and three dimensions.

PubMed

Trilleras, Jorge; Quiroga, Jairo; Cobo, Justo; Marchal, Antonio; Nogueras, Manuel; Low, John N; Glidewell, Christopher

2008-10-01

Ten new N(4)-substituted 1H-pyrazolo[3,4-d]pyrimidine-4,6-diamines have been synthesized and the structures of nine of them are reported here, falling into two clear groups, those which are stoichiometric hydrates and those which crystallize in solvent-free forms. In each of N(4)-methyl-N(4)-phenyl-1H-pyrazolo[3,4-d]pyrimidine-4,6-diamine, C(12)H(12)N(6) (I), N(4)-cyclohexyl-N(4)-methyl-1H-pyrazolo[3,4-d]pyrimidine-4,6-diamine, C(12)H(18)N(6) (II), and N(4)-(3-chlorophenyl)-1H-pyrazolo[3,4-d]pyrimidine-4,6-diamine, C(11)H(9)ClN(6) (III), the molecules are linked into hydrogen-bonded sheets. The molecules of 2-{4-(6-amino-1H-pyrazolo[3,4-d]pyrimidin-4-yl)piperazin-1-yl}ethanol, C(11)H(17)N(7)O (IV), are linked into a three-dimensional framework, while the structure of N(4)-methyl-N(4)-(4-methylphenyl)-1H-pyrazolo[3,4-d]pyrimidine-4,6-diamine monohydrate, C(13)H(14)N(6) x H(2)O (V), is only two-dimensional despite the presence of five independent hydrogen bonds. The stoichiometric hemihydrates N(4)-ethyl-N(4)-phenyl-1H-pyrazolo[3,4-d]pyrimidine-4,6-diamine hemihydrate, C(13)H(14)N(6) x 0.5 H(2)O (VI) and N(4)-(4-methoxyphenyl)-N(4)-methyl-1H-pyrazolo[3,4-d]pyrimidine-4,6-diamine hemihydrate, C(13)H(14)N(6)O x 0.5 H(2)O (VII), exhibit remarkably similar sheet structures, despite different space groups and Z' values, Z' = 0.5 in C2/c for (VI) and Z' = 1 in P1 for (VII). N(4)-4-Benzyl-N(4)-phenyl-1H-pyrazolo[3,4-d]pyrimidine-4,6-diamine monohydrate, C(18)H(16)N(6) x H(2)O (VIII), crystallizes with Z' = 2 in P2(1)/n, and the four independent molecular components are linked into sheets by a total of 11 intermolecular hydrogen bonds. The sheet structure in {4-(pyrrolidin-1-yl)-1H-pyrazolo[3,4-d]pyrimidine-6-amine} ethanol hemisolvate hemihydrate, C(9)H(12)N(6).0.5C(2)H(6)O x 0.5 H(2)O (IX), is built from the pyrimidine and water components only; it contains eight independent hydrogen bonds, and it very closely mimics the sheets in (VI) and (VII); the ethanol molecules are pendent from these sheets. The N(4)-alkyl-N(4)-aryl-4-aminopyrazolopyrimidine molecules in (I), (V)-(VIII) all adopt very similar conformations, dominated in each case by an intramolecular C-H...pi(arene) hydrogen bond: this interaction is absent from (III) where the molecular conformation is entirely different and probably dominated by the intermolecular hydrogen bonds.

Word Criticality Analysis. MOS: 67N. Skill Levels 1 & 2

DTIC Science & Technology

1981-09-01

12 1 , lat 0.. 71N 4 1 s,1 󈧅 119 *I .!Ill4 r ITr L34 U., p I*. 1, r-*44,1I6 C. I ", il. TD %T i - 96’ !04- 2,1 -i: l st a64 1104 121! tio 2...14 1’.1 !$04 4:4 11.1* :74 :’~ ~4 te 4 , 4?. 4.. 7 ., !:j-q1 , **)4 1Q3 *2 .1 .~ 4134 . 1.,’ 4- 1 41st -74 Ott. 󈧒 *4 . ,4 4,7Y t 1 46520 n190 37.1

Automatic Extraction of 3D Models From an Airborne Video Sequence

DTIC Science & Technology

2008-01-01

4*¤B=@’(Q5 Y1)+*d 2*J: : ,_j%_ ! 4 ?*B 2) "? *B4t1’ +& .b? ;wc 2%’&( 4C ...c¦ §´³!¡T± %_+ )f8G !&0& B= # 4&( , 4&(&( #%)1)(&�f&0 ,_+&0&( )#,_+7 ! : ,’& 4C µU¶ ���)�D...8217&( 4C µU¸  ���)¹a 4�������DºD¡P» "Q$% ] 4&( , 4&(& 4* d,_4& ")d d )P: "P%’&( > ")P !8 a

Molecular mechanism of the dual activity of 4EGI-1: Dissociating eIF4G from eIF4E but stabilizing the binding of unphosphorylated 4E-BP1

DOE PAGES

Sekiyama, Naotaka; Arthanari, Haribabu; Papadopoulos, Evangelos; ...

2015-07-13

The eIF4E-binding protein (4E-BP) is a phosphorylation-dependent regulator of protein synthesis. The nonphosphorylated or minimally phosphorylated form binds translation initiation factor 4E (eIF4E), preventing binding of eIF4G and the recruitment of the small ribosomal subunit. Signaling events stimulate serial phosphorylation of 4E-BP, primarily by mammalian target of rapamycin complex 1 (mTORC1) at residues T 37/T 46, followed by T 70 and S 65. Hyperphosphorylated 4E-BP dissociates from eIF4E, allowing eIF4E to interact with eIF4G and translation initiation to resume. Because overexpression of eIF4E is linked to cellular transformation, 4E-BP is a tumor suppressor, and up-regulation of its activity is amore » goal of interest for cancer therapy. A recently discovered small molecule, eIF4E/eIF4G interaction inhibitor 1 (4EGI-1), disrupts the eIF4E/eIF4G interaction and promotes binding of 4E-BP1 to eIF4E. Structures of 14- to 16-residue 4E-BP fragments bound to eIF4E contain the eIF4E consensus binding motif, 54YXXXXLΦ 60 (motif 1) but lack known phosphorylation sites. We report in this paper a 2.1-Å crystal structure of mouse eIF4E in complex with m 7GTP and with a fragment of human 4E-BP1, extended C-terminally from the consensus-binding motif (4E-BP1 50–84). The extension, which includes a proline-turn-helix segment (motif 2) followed by a loop of irregular structure, reveals the location of two phosphorylation sites (S 65 and T 70). Our major finding is that the C-terminal extension (motif 3) is critical to 4E-BP1–mediated cell cycle arrest and that it partially overlaps with the binding site of 4EGI-1. Finally, the binding of 4E-BP1 and 4EGI-1 to eIF4E is therefore not mutually exclusive, and both ligands contribute to shift the equilibrium toward the inhibition of translation initiation.« less

Solid state reactions of CeO 2, PuO 2, (U,Ce)O 2 and (U,Pu)O 2 with K 2S 2O 8

NASA Astrophysics Data System (ADS)

Keskar, Meera; Kasar, U. M.; Mudher, K. D. Singh; Venugopal, V.

2004-09-01

Solid state reactions of CeO 2, PuO 2 and mixed oxides (U,Ce)O 2 and (U,Pu)O 2 containing different mol.% of Ce and Pu, were carried out with K 2S 2O 8 at different temperatures to identify the formation of various products and to investigate their dissolution behaviour. X-ray, chemical and thermal analysis methods were used to characterise the products formed at various temperatures. The products obtained by heating two moles of K 2S 2O 8 with one mole each of CeO 2, PuO 2, (U,Ce)O 2 and (U,Pu)O 2 at 400 °C were identified as K 4Ce(SO 4) 4, K 4Pu(SO 4) 4, K 4(U,Ce)(SO 4) 4 and K 4(U,Pu)(SO 4) 4, respectively. K 4Ce(SO 4) 4 further decomposed to form K 4Ce(SO 4) 3.5 at 600 °C and mixture of K 2SO 4 and CeO 2 at 950 °C. Thus the products formed during the reaction of 2K 2S 2O 8 + CeO 2 show that cerium undergoes changes in oxidation state from +4 to +3 and again to +4. XRD data of K 4Ce(SO 4) 4 and K 4Ce(SO 4) 3.5 were indexed on triclinic and monoclinic system, respectively. PuO 2 + 2K 2S 2O 8 reacts at 400 °C to form K 4Pu(SO 4) 4 which was stable upto 750 °C and further decomposes to form K 2SO 4 + PuO 2 at 1000 °C. The products formed at 400 °C during the reactions of the oxides and mixed oxides were found to be readily soluble in 1-2 M HNO 3.

Low Volatile Organic Compound (VOC) Chemical Agent Resistant Coating (CARC)

DTIC Science & Technology

2000-04-01

hv1p 30 0 4 7 120 40 B15 +++--·····-+ 46168 36521 28 75 5 hv1p 30 0 2 3 75 80 Bl6 ++++++++++++ 46168 36521 28 120 30 conv 240 I 4 7 120 80 Low...Conventional· Bl2 28 HVLP Bl3 7 Conventional 1.4 1.2 2 Bl4 7 HVLP 1.1 2.3 4 BlS 28 HVLP B16 28 Conventional Notes: I. Only panel sets coated with...p p Bl4 572 574 3.0 4.0 4.0 3.5 p p BIS 274 243 4.0 4.0 4.0 4.5 p p Bl6 360 334 4.0 4.0 4.0 4.0 p p Experimental Set WR 7 days /lSO"C Oil

Upper Atmosphere Research Report Number 5

DTIC Science & Technology

1948-06-17

instrument was recovered, however, and in good condition. TRAJECTORY ALTITUDE AND VELOCITY Vb TIME 1Q170 T- 170 ISO ----- -- d *--- -------- 150 1600-A...8217aa- 6- 2~~D v Y 0 0 , 1 3$%-3p’P 0 Fel UL !UAT .21 ,’S P I1L11*1111-z Fe -II RI a D- 0C Si I3e 3P- 4s3P0 02400 2500 2600 27000 WAVELENGTH...tototot- to 4 L (4 ~~~~4 toý to ).- IDt 0 4 mo ao 0--0)o- cot i0 t CU1 Ci) M4 ISo &a0c 0c nU n s U4C - ~ r e 4.o..4 -W--I~4 w-t4 M..4(4.4 (4(4l C Mt

Structure of complexes of uranyl succinate with carbamide and dimethylurea

NASA Astrophysics Data System (ADS)

Serezhkina, L. B.; Grigor'ev, M. S.; Seliverstova, N. V.; Serezhkin, V. N.

2017-09-01

Three new succinate-containing complexes of uranyl with carbamide ( Urea) and N,N'-dimethylurea ( s-Dmur) are synthesized and studied by IR spectroscopy and X-ray diffraction. Structures of the same type, [UO2( Urea)4(H2O)][(UO2)2(C4H4O4)3] · 3H2O and [UO2( Urea)4(H2O)][(UO2)2(C4H4O4)3] · 2 Urea contain two sorts of uranium-containing complex groups, namely, mononuclear [UO2( Urea)4(H2O)]2+ cations and two-dimensional [(UO2)2(C4H4O4)3]2- anions described by crystal-chemical formulas AM 5 1 and A 2 Q 3 02, respectively ( A = UO2 2+, M 1 = Urea or H2O, Q 02 = C4H4O4 2-), and differ only in the nature of noncoordinated molecules—water and carbamide. The main structural groups of the [(UO2)2(C4H4O4)2( s-Dmur)3] crystals are [(UO2)2(C4H4O4)2( s-Dmur)3] chains belonging to the A 2 Q 2 02 M 3 1 ( A = UO2 2+, Q 02 = C4H4O4 2-, M 1 = s-Dmur) crystal-chemical group. Specific features of intermolecular interactions in the crystal structures are revealed using the Voronoi-Dirichlet method of molecular polyhedra.

Geographic List of Prime Contract Awards. Oct 1992-Sep 1993. FY 1993. (Akron, New York-Williston, North Dakota). Part 9

DTIC Science & Technology

1994-03-01

MOffI 01 :Ic (0 I 141 o)CT Co) C000 4.j-4-4 0 -4 0 0000000 0 0 00ý- -4,ý-4 ý00 ýO O.4 400 -4000 0 110u I co 0 IV i d ( D in n -i e .cn 4~N cn CuMI c - - n...dea Dist Spoolal 480 Best Available Copy LLLA 4o CoC?4 4J i. -. Q U >U 0 0.C d ) U~ ~ > ) C C 1- 62 fU 62 M - L. 0 0 0A oa841 1- m4 M4. w2’ ’U 6 4-62...8217U U, 0 &A 4141 0 U. 4.. Z 2’ ( D x0 = L 1- M 0 41 M 3: 1.- u 41 1DU 6 0 >a1 4- 4- 4- -40 2L 0 £O041 0 4- C U *- 0 CL. I.. U 0 ’ - 5 0 0 C a 0 x u Uc 0

Prime Contract Awards Alphabetically by Contractor, by State or Country, and Place, Fiscal Year 1987. Part 14. Okinawa Kankyo-Pultrusions Corporation.

DTIC Science & Technology

1987-01-01

1 00 aca Y. 0 139-4-4M ᝰ  ɘ-4-400-4-4-f 1(2 z 0 I= 09 Cie w I -IC Cn 10-4 w U 000 0 r, 0 0 1 4c cn 1 4c C-) cn ZLn com -4-0-0 0.00 CL in 0 0 (L...0 No N N) (O(ONNC ". N1 NL C -I 4 (nI Z- -’ A Mz - COm 0140 -4,- n( I o )MN&1 0 I n 00 04 - J " cc t 0140 1(4 14C .4’ NNN NN 80104000 0-4 N () 0 (0 V...j 0 0 .4 0 00 MO 3 0 <-Cc00m-cc-c <- x, ~4.-C < x-I-x-C < < 0 N 0N 3 0N ON 1- 0 304 Com 004 0.4 l’ 0 ) 0- t- - 0 0 1’ ) 1-o 0 0 0 3 30 *4U, 0 0 0) -4

Scoping Assessment for Developing a Water Quality Monitoring Plan to Support Application of the CE-QUAL-W2 Hydrodynamic and Water Quality Model to the Lower Missouri River downstream of Gavins Point Dam

DTIC Science & Technology

2010-04-01

4.2 2.1 1.4 OMA 5.1 3.1 2.3 1.0 NCNE 6.3 4.3 3.5 2.1 1.2 RUNE 7.2 5.2 4.4 3.1 2.1 0.9 STJ 8.7 6.7 5.9 4.5 3.6... RUNE 6.6 4.7 4.1 2.8 1.9 0.8 STJ 8.0 6.1 5.4 4.2 3.3 2.2 1.4 MKC 9.2 7.3 6.6 5.4 4.5 3.4 2.6 1.2 WVMO 10.8 8.9 8.2 7.0 6.1 5.0...2.9 1.5 0.9 OMA 3.5 2.1 1.6 0.7 NCNE 4.3 2.9 2.4 1.5 0.8 RUNE 5.0 3.6 3.0 2.1 1.4 0.6 STJ 6.0 4.6 4.1 3.1 2.5 1.7

Prime Contract Awards Alphabetically by Contractor, by State or Country, and Place. Part 5. (Comtech Microwave Corp.-DOB Corporation)

DTIC Science & Technology

1989-01-01

8217)N1-orn-4 04-4.-4 on 0 (D c’)N"U) N CV3 If1. I moo0 If 0o c) 4N ( 4 -4 .4 -40 -4Nci-4 -414) 003a4a1 moo If Nn -4 >3 100 Coc 1’) -4,1 a01)0 t mo 4 0)N...Col01ə ’ IfN 1.- 0 r,0 a - 0 1" 0 4 0NC14 M M 40000o r-NjN I,_-4 " 411.I’ 14 iI 400fto 1 0 140 10 4000 10000 ol 100 1 t I-N a 401<-4 110) (0 00 00 10...1-1-1-1-1-1-1- . 1- j-1-1-1 - . . -j -. 0 )JJ . J. 1 . . . . j . met M)-4 44 000 a 0 0 0 0 0 0 0 0 00 0 0 0 0 0 0 0 0 C.4 If ( 44< 100 00 00 -j4 of

Prime Contract Awards Alphabetically by Contractor, by State or Country, and Place, Fiscal Year 1985. Part 5 (Columbia Asphalt & Gravel Inc - Dela Tek Inc).

DTIC Science & Technology

1985-01-01

40 40 4000 1 O- 4 00 000 0 C 40 40 ca c 1- Q 4- - In In In o - In 0 co l. 40 l N N 𔃺 C)3 0 0N In In IN N I N I 𔃺’ D coca In4 Of4 I 4 W 4 W 1 NWWI. 4...1( n r- PP, - P - - - )0 00 awl-I qt0( Coo 0- -I41-- <- M (0 " 00000000mm) C 00 000 om- -1-4I I.NOI1)1) W1 ’. * * (0 .17 0000 -CM 0.3 0C4C - Coala Ow... coca r-. 4.-U, M LA4( 44( 0I NY NN4 NNic N N ( C) N (0" M (0 04o -44 3 4( 4 44 44 4d -C 4 33 4 -4(0 K m( -4 43l CK00 0) 00 00 0 0 0 00 0 0U 0)co C I

7 CFR 29.1181 - Summary of standard grades.

Code of Federal Regulations, 2011 CFR

2011-01-01

... Agriculture Regulations of the Department of Agriculture AGRICULTURAL MARKETING SERVICE (Standards, Inspections, Marketing Practices), DEPARTMENT OF AGRICULTURE COMMODITY STANDARDS AND STANDARD CONTAINER... B6KV 7 Mixed Grades M4F M4KR M4KM M4GK M5F M5KM M5GK 15 Grades of Green B4G B4GK C4G C4GK X4G X4GK P4G...

7 CFR 29.1181 - Summary of standard grades.

Code of Federal Regulations, 2010 CFR

2010-01-01

... Agriculture Regulations of the Department of Agriculture AGRICULTURAL MARKETING SERVICE (Standards, Inspections, Marketing Practices), DEPARTMENT OF AGRICULTURE COMMODITY STANDARDS AND STANDARD CONTAINER... B6KV 7 Mixed Grades M4F M4KR M4KM M4GK M5F M5KM M5GK 15 Grades of Green B4G B4GK C4G C4GK X4G X4GK P4G...

Aiding USAF/UPT (Undergraduate Pilot Training) Aircrew Scheduling Using Network Flow Models.

DTIC Science & Technology

1986-06-01

51 3.4 Heuristic Modifications ............ 55 CHAPTER 4 STUDENT SCHEDULING PROBLEM (LEVEL 2) 4.0 Introduction 4.01 Constraints ............. 60 4.02...Covering" Complete Enumeration . . .. . 71 4.14 Heuristics . ............. 72 4.2 Heuristic Method for the Level 2 Problem 4.21 Step I ............... 73...4.22 Step 2 ............... 74 4.23 Advantages to the Heuristic Method. .... .. 78 4.24 Problems with the Heuristic Method. . ... 79 :,., . * CHAPTER5

4,2’:6’,4”- and 3,2’:6’,3”-Terpyridines: The Conflict between Well-Defined Vectorial Properties and Serendipity in the Assembly of 1D-, 2D- and 3D-Architectures

PubMed Central

Klein, Y. Maximilian; Prescimone, Alessandro; Constable, Edwin C.

2017-01-01

A comparative investigation of the coordination assemblies formed between Co(NCS)2 and two monotopic 4,2’:6’,4’’-terpyridine (4,2’:6’,4”-tpy) ligands or two related ditopic ligands is reported. Crystals were grown by layering MeOH solutions of Co(NCS)2 over a CHCl3 or 1,2-C6H4Cl2 solution of the respective ligand at room temperature. With 4’-(2-methylpyrimidin-5-yl)-4,2’:6’,4”-terpyridine (6), the 1D-coordination polymer {[Co2(NCS)4(MeOH)4(6)2]∙2MeOH∙8H2O}n assembles with 6 coordinating only through the outer N-donors of the 4,2’:6’,4”-tpy unit; coordination by the MeOH solvent blocks two cobalt coordination sites preventing propagation in a higher-dimensional network. A combination of Co(NCS)2 and 1-(4,2‘:6’,4”-terpyridin-4’-yl)ferrocene (7) leads to {[Co(NCS)2(7)2]∙4CHCl3}n which contains a (4,4) net; the 2D-sheets associate through π-stacking interactions between ferrocenyl and pyridyl units. A 3D-framework is achieved through use of the ditopic ligand 1,4-bis(npropoxy)-2,5-bis(4,2’:6’,4”-terpyridin-4’-yl)benzene (8) which acts as a 4-connecting node in {[Co(NCS)2(8)2]∙2C6H4Cl2}n; the combination of metal and ligand planar 4-connecting nodes results in a {65.8} cds net. For a comparison with the coordinating abilities of the previously reported 1,4-bis(noctoxy)-2,5-bis(4,2’:6’,4”-terpyridin-4’-yl)benzene (3), a more flexible analogue 9 was prepared. {[Co(NCS)2(9)]∙2CHCl3}n contains a (4,4) net defined by both metal and ligand planar 4-connecting nodes. The noctoxy tails of 9 protrude from each side of the (4,4) net and thread through adjacent sheets; the arene-attached noctoxy chains associate through a combination of van der Waals and C–H...π interactions. PMID:28773088

All Prime Contract Awards by State or Country, Place, and Contractor, FY 85. Part 5 (Arapahoe, Colorado - Washington, D.C.).

DTIC Science & Technology

1985-01-01

444444. < MW 0 U 0. U <- OU cI- 0 < :412 8-4 M" I= Ul N >9 ? -4 cc0 a* N - 00 W(0 w.1 co. o U jNNc)InD9- i901I 00 0-4 <-4 Ufl." 20 > -4 ado 30 CI0 1... Porno .....) 4 : W&P 040( 0-I4 4004444 44040000004-44-40.44.44.44-44.44.--4-4.4.4-4.-44-4-4.40.44- I.- do I I a -’ ~ ~ N I , ICPN -440flOo r ntOO40 0-N

Comprehensive Monitoring Program: Final Air Quality Data Assessment Report for FY90, Version 3.1 Volume 3

DTIC Science & Technology

1991-09-01

Monitoring Stations Figure 4.1-1 X /Q Dispersion for Phase I Figure 4.1-2 X /Q Dispersion for Phase 2-Stage 1 Figure 4.1-3 X /Q Dispersion for Phase 2...Stage 2 Fp Figure 4.1-4 X /Q Dispersion for Phase 3 Figure 4.1-5 X /Q Dispersion for Phase 4 • Figure 4.1-6 Sources of Regulated Pollutants in RMA...Arsenic Results by Phase "Figure 4.4-7 Cadmium Results by Phase Figure 4.4-8 X /Q Dispersion and Basin F Metals for 9/6/88 * Figure 4.4-9 X /Q Dispersion

Nutritional stress affects an atypical cap-binding protein in Leishmania.

PubMed

Zinoviev, Alexandra; Manor, Shachar; Shapira, Michal

2012-12-01

Many eukaryotes encode multiple isoforms of the cap-binding translation initiation factor (eIF4E). Leishmanias and other trypanosomatids encode four paralogs of this protein, but none can complement the eIF4E function in a yeast mutant. A low conservation is observed between the four paralogs, suggesting they assist these organisms survive a multitude of conditions encountered throughout the life cycle. Earlier attempts to decipher their function led to identification of LeishIF4E-4 as the canonical translation initiation factor. LeishIF4E-1 appears to function during thermal stress, via a mechanism not yet understood. LeishIF4E-3 hardly binds cap-4 and is, therefore, less likely to serve as a typical initiation factor. Although it interacts with an eIF4G homolog, LeishIF4G-4, the two polypeptides do not co-migrate on sucrose gradients. While LeishIF4E-3 enters large particles that increase in size during nutritional stress, LeishIF4G-4 is found only in the top fractions. Confocal microscopy localized LeishIF4E-3 (but not LeishIF4G-4) within nutritional stress-induced granules. Accordingly, interaction between the two proteins reduced upon starvation. We therefore propose that under normal conditions, LeishIF4G-4 sequesters LeishIF4E-3 in the cytoplasm. During a nutritional stress, LeishIF4E-3 is modified and released from LeishIF4G-4 to enter stress granules, where inactive mRNAs are stored. Binding of LeishIF4G-4 to LeishIF4E-3 requires a short peptide within the LeishIF4G-4 N-terminus, which bears no similarity to the consensus 4E-binding peptide, YXXXXLΦ. Mutational analysis combined with structure prediction indicates that this interaction is based on an obligatory, conserved α helix in LeishIF4G-4. These features further highlight the uniqueness of LeishIF4E-3 and how it interacts with its binding partners.

40 CFR 180.607 - Spiromesifen; tolerances for residues.

Code of Federal Regulations, 2014 CFR

2014-07-01

...-oxaspiro[4.4]non-3-en-2-one moiety, calculated as the stoichiometric equivalent of spiromesifen, in the... measuring only the sum of spiromesifen [2-oxo-3-(2,4,6-trimethylphenyl)-1-oxaspiro[4.4]non-3-en-4-yl 3,3-dimethylbutanoate] and 4-hydroxy-3-(2,4,6-trimethylphenyl)-1-oxaspiro[4.4]non-3-en-2-one, calculated as the...

40 CFR 180.607 - Spiromesifen; tolerances for residues.

Code of Federal Regulations, 2013 CFR

2013-07-01

...-oxaspiro[4.4]non-3-en-2-one moiety, calculated as the stoichiometric equivalent of spiromesifen, in the... measuring only the sum of spiromesifen [2-oxo-3-(2,4,6-trimethylphenyl)-1-oxaspiro[4.4]non-3-en-4-yl 3,3-dimethylbutanoate] and 4-hydroxy-3-(2,4,6-trimethylphenyl)-1-oxaspiro[4.4]non-3-en-2-one, calculated as the...

40 CFR 180.607 - Spiromesifen; tolerances for residues.

Code of Federal Regulations, 2011 CFR

2011-07-01

...-oxaspiro[4.4]non-3-en-2-one moiety, calculated as the stoichiometric equivalent of spiromesifen, in the... measuring only the sum of spiromesifen [2-oxo-3-(2,4,6-trimethylphenyl)-1-oxaspiro[4.4]non-3-en-4-yl 3,3-dimethylbutanoate] and 4-hydroxy-3-(2,4,6-trimethylphenyl)-1-oxaspiro[4.4]non-3-en-2-one, calculated as the...

40 CFR 180.607 - Spiromesifen; tolerances for residues.

Code of Federal Regulations, 2012 CFR

2012-07-01

...-oxaspiro[4.4]non-3-en-2-one moiety, calculated as the stoichiometric equivalent of spiromesifen, in the... measuring only the sum of spiromesifen [2-oxo-3-(2,4,6-trimethylphenyl)-1-oxaspiro[4.4]non-3-en-4-yl 3,3-dimethylbutanoate] and 4-hydroxy-3-(2,4,6-trimethylphenyl)-1-oxaspiro[4.4]non-3-en-2-one, calculated as the...

Alpha List of Prime Contract Awards. Oct 91 - Sep 92. FY 92. (Reichlmeter - Season All Industries Inc)

DTIC Science & Technology

1993-01-01

11 0 1 b.4- 1 CL- 0 0 - V0- ~ - . - -II 0w- 0 0 0 0 0 0 0 Ii ’ 1 I O C 4 0 0 (D a0 - ( N 1,4 40 4 4 4 4 4 0 4 4 0 4 4 4coo0 400 it 1M (7 4 0 0 Ip -j...C.Q00000 0C0 k0 a010 00 000 C) N5 N 1-if Nf N IP -NN N NN 14P4NN NN N NN N N NI N NN N N NN’N NJ10Q-t- if 7 ,2ZZZZ ZZZZZZZZZZZZZZ2ZZZ ZZ zzz 4w 140000...0 0< 4 0ɜ 04 0ɜɜ 04=(0C R 2 2 Z z 22 Zzz 2 2 222 z PP P00-w P4 N 0 44 0 4 10wCo0mm < ca 0 iP 0 0 0 - P 0 0c c % U -4mi0 N m0 PIS 0-400 N 0

Non-analytic terms from nested divergences in maximal supergravity

NASA Astrophysics Data System (ADS)

Basu, Anirban

2016-07-01

The {D}4{{ R }}4 and {D}6{{ R }}4 coefficient functions in the effective action of type II string theory compactified on T d contain terms of the form {{ E }}1{{ln}}{g}d and {{ E }}2{({{ln}}{g}d)}2 in specific dimensions, where g d is the T-duality invariant string coupling, and {{ E }}1 and {{ E }}2 are U-duality invariant coefficient functions. We derive these non-analytic terms from nested ultraviolet divergences in two and three loop maximal supergravity. For the {D}4{{ R }}4 coupling, the contribution involves {{ E }}{{ R }4}{{ln}}{g}d, while for the {D}6{{ R }}4 coupling, it involves {{ E }}{{ R }4}{{ln}}{g}d, {{ E }}{D2{{ R }}4}{({{ln}}{g}d)}2 and {{ E }}{D4{{ R }}4}{{ln}}{g}d; where {{ E }}{{ R }4}, {{ E }}{D2{{ R }}4} and {{ E }}{D4{{ R }}4} are the {{ R }}4, {D}2{{ R }}4 and {D}4{{ R }}4 coefficient functions respectively. The contribution from {{ E }}{D2{{ R }}4}, the coefficient function of an amplitude that vanishes onshell, arises from a two loop nested subdivergence of the three loop amplitude.

Dollar Summary of Prime Contract Awards by Contractor, State or Country, and Place, FY 88. Part 6 (Spick & Spain Maintenance, Inc.-Zymed, Inc.).

DTIC Science & Technology

1988-01-01

A. 3000O.LiO. 0 C 0 ) 0- m-) CDZ( 1 01 el i 0 I Q ,InL 1 01 I I I I 0I0 I En I I V I 1-- 0fI J ))(( 1 U-I n M-C1 Ir I CI) ZI00 MU m’ uC’ (0(0) m~e 0...w w w w wC 0 de <<-l 0 10 0) -4z -4 1 C>IWWW 4L4WW- 0 I--1 U) 101 CCC 0 0L W U’ 2i 000 00 W00 0i 0i- i WI- 4) ’-4- 00-I C1 0 a 4 4W w 4 . C 4 " 4.U...000 00 0 0 04 0 000 00V I Z4 I -- 4> .. 4 "U 4- .4.I- " P.4-4 )- "- 0) 4- >>- 0. 04-2 4. Q. M 0 m J CL)00 0))0 C0 a_ a.C -C( aULa L L M a a La D Z3

TRPV4 and AQP4 Channels Synergistically Regulate Cell Volume and Calcium Homeostasis in Retinal Müller Glia

PubMed Central

Jo, Andrew O.; Phuong, Tam T.T.; Verkman, Alan S.; Yarishkin, Oleg; MacAulay, Nanna

2015-01-01

Brain edema formation occurs after dysfunctional control of extracellular volume partly through impaired astrocytic ion and water transport. Here, we show that such processes might involve synergistic cooperation between the glial water channel aquaporin 4 (AQP4) and the transient receptor potential isoform 4 (TRPV4), a polymodal swelling-sensitive cation channel. In mouse retinas, TRPV4 colocalized with AQP4 in the end feet and radial processes of Müller astroglia. Genetic ablation of TRPV4 did not affect the distribution of AQP4 and vice versa. However, retinas from Trpv4−/− and Aqp4−/− mice exhibited suppressed transcription of genes encoding Trpv4, Aqp4, and the Kir4.1 subunit of inwardly rectifying potassium channels. Swelling and [Ca2+]i elevations evoked in Müller cells by hypotonic stimulation were antagonized by the selective TRPV4 antagonist HC-067047 (2-methyl-1-[3-(4-morpholinyl)propyl]-5-phenyl-N-[3-(trifluoromethyl)phenyl]-1H-pyrrole-3-carboxamide) or Trpv4 ablation. Elimination of Aqp4 suppressed swelling-induced [Ca2+]i elevations but only modestly attenuated the amplitude of Ca2+ signals evoked by the TRPV4 agonist GSK1016790A [(N-((1S)-1-{[4-((2S)-2-{[(2,4-dichlorophenyl)sulfonyl]amino}-3-hydroxypropanoyl)-1-piperazinyl]carbonyl}-3-methylbutyl)-1-benzothiophene-2-carboxamide]. Glial cells lacking TRPV4 but not AQP4 showed deficits in hypotonic swelling and regulatory volume decrease. Functional synergy between TRPV4 and AQP4 during cell swelling was confirmed in the heterologously expressing Xenopus oocyte model. Importantly, when the swelling rate was osmotically matched for AQP4-positive and AQP4-negative oocytes, TRPV4 activation became independent of AQP4. We conclude that AQP4-mediated water fluxes promote the activation of the swelling sensor, whereas Ca2+ entry through TRPV4 channels reciprocally modulates volume regulation, swelling, and Aqp4 gene expression. Therefore, TRPV4–AQP4 interactions constitute a molecular system that fine-tunes astroglial volume regulation by integrating osmosensing, calcium signaling, and water transport and, when overactivated, triggers pathological swelling. SIGNIFICANCE STATEMENT We characterize the physiological features of interactions between the astroglial swelling sensor transient receptor potential isoform 4 (TRPV4) and the aquaporin 4 (AQP4) water channel in retinal Müller cells. Our data reveal an elegant and complex set of mechanisms involving reciprocal interactions at the level of glial gene expression, calcium homeostasis, swelling, and volume regulation. Specifically, water influx through AQP4 drives calcium influx via TRPV4 in the glial end foot, which regulates expression of Aqp4 and Kir4.1 genes and facilitates the time course and amplitude of hypotonicity-induced swelling and regulatory volume decrease. We confirm the crucial facets of the signaling mechanism in heterologously expressing oocytes. These results identify the molecular mechanism that contributes to dynamic regulation of glial volume but also provide new insights into the pathophysiology of glial reactivity and edema formation. PMID:26424896

Identification and characterization of a second CD4-like gene in teleost fish.

PubMed

Dijkstra, Johannes Martinus; Somamoto, Tomonori; Moore, Lindsey; Hordvik, Ivar; Ototake, Mitsuru; Fischer, Uwe

2006-02-01

In fish, T cell subdivision is not well studied, although CD8 and CD4 homologues have been reported. This study describes a second teleost CD4-like gene, CD4-like 2 (CD4L-2). Two rainbow trout copies of this gene were found, -2a and -2b, encoding molecules sharing 81% aa identity. The 2a/2b duplication may be related to tetraploid ancestry of salmonid fishes. In the Fugu genome CD4L-2 lies head to tail with an earlier reported, very different CD4-like gene [Suetake, H., Araki, K., Suzuki, Y., 2004. Cloning, expression, and characterization of fugu CD4, the first ectothermic animal CD4. Immunogenetics 56, 368-374], which was designated CD4L-1 in the present article. The flanking genes of the Fugu CD4L-1 and CD4L-2 are reminiscent of the genes surrounding CD4 and LAG-3 in mammals. However, neither synteny nor phylogenetic analysis could decide between CD4 and LAG-3 identity for the fish CD4L genes. CD4L-1 and CD4L-2 share a tyrosine protein kinase p56(lck) binding motif in the cytoplasmic tail with CD4 but not with LAG-3. Trout CD4L-2 expression is highest in the thymus, similar to mammalian and chicken CD4, whereas Fugu CD4L-1 expression was highest in the spleen. However, CD4L-2 encodes only two IG-like domains, whereas CD4L-1, CD4 and LAG-3 encode four. The CD4-like genes 1 and 2 in fish apparently went through an evolution different from that of LAG-3 and CD4 in higher vertebrates.

1D nanostructured Na7V4(P2O7)4(PO4) as high-potential and superior-performance cathode material for sodium-ion batteries.

PubMed

Deng, Chao; Zhang, Sen

2014-06-25

Tailoring materials into nanostructure offers unprecedented opportunities in the utilization of their functional properties. High-purity Na7V4(P2O7)4(PO4) with 1D nanostructure is prepared as a cathode material for rechargeable Na-ion batteries. An efficient synthetic approach is developed by carefully controlling the crystal growth in the molten sodium phosphate. Based on the XRD, XPS, TG, and morphological characterization, a molten-salt assisted mechanism for nanoarchitecture formation is revealed. The prepared Na7V4(P2O7)4(PO4) nanorod has rectangle sides and preferential [001] growth orientation. GITT evaluation indicates that the sodium de/intercalation of Na7V4(P2O7)4(PO4) nanorod involves V(3+)/V(4+) redox reaction and Na5V(3.5+)4(P2O7)4(PO4) as intermediate phase, which results in two pairs of potential plateaus at the equilibrium potentials of 3.8713 V (V(3+)/V(3.5+)) and 3.8879 V (V(3.5+)/V(4+)), respectively. The unique nanoarchitecture of the phase-pure Na7V4(P2O7)4(PO4) facilitates its reversible sodium de/intercalation, which is beneficial to the high-rate capability and the cycling stability. The Na7V4(P2O7)4(PO4) cathode delivers 80% of the capacity (obtained at C/20) at the 10 C rate and 95% of the initial capacity after 200 cycles. Therefore, it is feasible to design and fabricate an advanced rechargeable sodium-ion battery by employment of 1D nanostructured Na7V4(P2O7)4(PO4) as the cathode material.

Polybrominated diphenyl ethers (PBDEs) in U.S. computers and domestic carpet vacuuming: possible sources of human exposure.

PubMed

Schecter, Arnold; Päpke, Olaf; Joseph, Jean Elizabeth; Tung, Kuang-Chi

2005-04-09

Polybrominated diphenyl ethers (PBDEs), a type of brominated flame retardant chemically and toxicologically similar to polychlorinated biphenyls (PCBs), are a class of emerging environmental and human contaminants. They have recently been detected in U.S. milk, blood, and food at the highest levels in the world. This pilot study was undertaken with the aim of determining levels of PBDE in the U.S. indoor environment, to assess the potential exposure to PBDEs from computer surfaces and carpets. Food of animal origin is the usual source of polychlorinated dibenzo-p-dioxin (PCDD), polychlorinated dibenzofurans (PCDF), and PCBs in humans, but there may also be environmental sources for intake of PBDEs. It was also our aim to characterize the PBDE congener profile in these indoor environmental samples. Four computer wipe samples and 9 domestic vacuum-sweeping samples were analyzed for 13 PBDE congeners, PBDEs 17 (2,2',4), 28 (2,4,4'?), 47 (2,2',4,4'?), 66 (2,3',4,4'?), 77 (3,3',4,4'?), 85 (2,2',3,4,4'?), 99 (2,2'4,4',5), 100 (2,2',4,4',6), 138 (2,2',3,4,4',5'?), 153 (2,2',4,4',5,5'?), 154 (2,2',4,4',5,6'?), 183 (2,2',3,4,4',5',6), and 209 (2,2',3,3',4,4',5,5',6,6'?). All samples tested positive for PBDEs. PBDE 209 was the dominant congener in all 4 computer wipe samples and in 7 out of the 9 vacuum dust samples. The congener profiles observed in this study varied considerably, a finding that has been observed previously. However these congener profiles differ from the pattern seen in U.S. human milk, human blood and in food, where PBDEs 47 and 99 predominate.

Terrain Considerations and Data Base Development for the Design and Testing of Devices to Detect Intruder-Induced Ground Motion

DTIC Science & Technology

1978-05-01

4 5-H 03 4) 0 5-. 4)H EL4 +,)r F-4 In5- 5q 4) 0 -r4 (n 0a0 4. ) >. ., m- (d COosv -0 0ca+ H 0a t-4 j~S.~C+H 4 5~C H co A’~ ) 4) U) U30~ ’’C Q 4 V...axial force on the cone. The force is measured by a load cell , and the vertical distance traveled is measured mechanically. Mechanical cone

An Experimental Study of Dropwise Condensation on Vertical Discs.

DTIC Science & Technology

1979-12-01

Tested--------------------- 45 Table II. Summary of Heat Transfer Results ---------------- 46 Table III. Thermophysical Properties of Pertinent Materials...flow for selected speci- ments. The values obtained for heat flux agreed within 22 per- cent. Using the values for heat flux, surface temperature and...4 n.* V- 4 n- C\\) *.- --t ~C m, z, C E-1 E-4 E-0 E4 46 N 4) ) Cd 4~ ~ C)4 S ) 0) 4- C) 4 0 4)0 .4E-4 UU I~ U 47 Thermophysical Properties 1. Thermal

An Empirical Investigation of the Effects of Inventory Stockage Models for Recoverable Items on Weapon System Availability.

DTIC Science & Technology

1981-06-01

Supply) is outdated , a large portion of the literature utilizes it. Therefore, the term NORS will be used interchangeably with what is today known as Not...00 4) *w-4 04- +4 U) 4) i- + 0 0 4) O U v~ rq C: OO) - -.4 4JI 0 O: b G)C ~ 4P .- rZOHN z D -H0 4- 4. CU C H ~ aSO C>o +0 -4 4 1 , H~ +0 W ) +O - g f41

Interlevel Correlations of Temperature and Density, Surface to 60 KM

DTIC Science & Technology

1980-05-14

N 4 W ON . .4 4. 40 N 2NW N N 0.04’ 44 0N4 I N no In CTnO 0y a. N N~ Wq I N 4 M ANA. 4N 4 4 N *f~ 0 I No0 N N won N N I 1 00A N 2 U 0 N In W 04* ON m...40. d 5- 14𔃺 ’ 4’C 110*0 44.4102 . itm 4m, 0 0 4wID oU MI .0 a’n ’. UI tao M u . o0’ Nj It%U’ .4n N 0 1. ow 4LJ N.41 .4 a MMM _j 0 D4 Z P2 0 w0 w

[Homoisoflavanones and stilbenes from fresh bulb of Scilla scilloides].

PubMed

Wang, Yan-Min; Fan, Meng-Yang; Li, Juan; Wang, Zhi-Min; Gao, Hui-Min

2014-10-01

Mian-Zao-Er was collected from the bulbs of Scilla scilloides (Lindl. ) Druce, belonging to the Hyacinthaceae family. 17 compounds were obtained using various column chromatographies on macroporus resin (HPD100), silica gel, Sephadex LH-20 and ODS, as well as semi-preparative HPLC. Their structures were elucidated on the basis of physicochemical properties and spectral data as 2-hydroxy-7-methoxyscillascillin (1), scillascillin (2), 5,7-dihydroxy-3',4'-dimethoxyspiro 2H-1-benzopyran-7'-bicyclo[4.2.0 ] octa [1,3,5 ] -trien } -4-one (3), socialinone (4), 4-methylresveratrol (5), (E)-resveratrol (6), scillavoneA (7), 3,9-di- hydroeucomnalin (8), 3-(3-hydroxy-4-methoxybenzyl) -5,7-dihydroxychroman-4-one (9), (3R)-5,7,3'-trihydroxy-4'-methoxyspiro (2H-1-benzopyran-7'-bicyclo[4, 2, 0] octa [1, 3, 5]-trien} -4-one (10), scillabene A (11), 2-hydroxyscillascillin (12), 3-(4-hydroxybenzyl) -5,7-dihydroxychroman-4-one (13), 3-( 4-hydroxybenzylidene) -5, 7-dihydroxychroman-4-one (14), 3-( 4-hydroxybenzyl) -5-hydroxy-7,8-dimethoxychroman-4-one (15), 3-(4-hydroxybenzyl) -5-hydroxy-6, 7-dimethoxychroman-4-one (16), and 3-(4-hydroxybenzyl)-5,8-hydroxy-7-methoxychroman-4-one (17). Among them, compounds 3, 4, 6, 9, 13 and 15-17 were isolated from this plant for the first time.

Specific interaction of CXCR4 with CD4 and CD8{alpha}: Functional analysis of the CD4/CXCR4 interaction in the context of HIV-1 envelope glycoprotein-mediated membrane fusion

DOE Office of Scientific and Technical Information (OSTI.GOV)

Basmaciogullari, Stephane; Pacheco, Beatriz; Department of Pathology, Division of AIDS, Harvard Medical School, Boston, MA 02115

2006-09-15

We investigated possible interactions between HIV-1 receptor (CD4) and the main coreceptors CXCR4 and CCR5. We found that CD4 and CXCR4 coexpressed in 293T cells form a complex that can be immunoprecipitated with antibodies directed against the extracellular domain of either protein. Mutagenesis revealed that the CD4/CXCR4 interaction maps to two previously uncharacterized basic motifs in the cytoplasmic domain of CD4. HIV-1 envelope glycoprotein-mediated membrane fusion was found to be independent of the ability of CD4 and CXCR4 to interact, whether fusion was studied in a virus-cell or a cell-cell model. However, this interaction might explain the adaptation of HIV-1more » to CXCR4 as an alternative to CCR5. We found that CXCR4 also interacts with the cytoplasmic domain of CD8{alpha} in a way that is similar to the CD4/CXCR4 interaction. The CD4/CXCR4 and CD8{alpha}/CXCR4 interactions may thus be involved in cellular signaling pathways shared by the CD4 and CD8{alpha} molecules.« less

DOE Office of Scientific and Technical Information (OSTI.GOV)

Vogel, E.A.F.

A series of new tetranuclear molybdenum(II) nitrile cluster derivatives is reported. Improvements in the synthetic routes to these and other derivatives is also reported. The single crystal x-ray structure of Mo/sub 4/Cl/sub 12//sup 4/minus// is modeled. New tetrameric nitrile derivatives with the stoichiometry Mo/sub 4/Cl/sub 8/(RCN)/sub 4/ (R = Pr/sup n/, Pr/sup i/, Bu/sup t/, PhCH/sub 2/) have been isolated by ligand exchange from Mo/sub 4/Cl/sub 8/(EtCN)/sub 4/ and/or direct synthesis from Mo/sub 4/Cl/sub 8/(PBu/sup n/sub 3//)/sub 4/. Mo/sub 4/Cl/sub 8/(Pr/sup n/CN)/sub 4/ was synthesized with higher yields and with simpler reaction conditions than Mo/sub 4/Cl/sub 8/(EtCN)/sub 4/. Improved syntheticmore » routes for R/sub 4/Mo/sub 4/Cl/sub 12/ (R = Et/sub 4/N, Pr/sub 4/N) have been developed. (Et/sub 4/N)/sub 4/Mo/sub 4/Cl/sub 12/ can be directly synthesized from the phosphine tetramer, circumventing the preparation of the reactive species-Mo/sub 4/Cl/sub 8/(EtCN)/sub 4/, which is the most difficult precursor to prepare. A change in reaction solvent, from dichloromethane or dichloroethane to chlorobenzene, in the preparation of (Pr/sub 4/N)/sub 4/Mo/sub 4/Cl/sub 12/ has permitted its isolation under less rigorous conditions and in high yield. A single crystal structure determination has been done on a sample of (Ph/sub 4/P)/sub 4/Mo/sub 4/Cl/sub 12/. Although, the quality of the data is poor, the structure of the Mo/sub 4/Cl/sub 12/ cluster core was refined. Four complex types have been found to fit the data. 22 refs., 12 figs., 7 tabs.« less

Analysis of eIF4E and 4EBP1 mRNAs in head and neck cancer.

PubMed

Sunavala-Dossabhoy, Gulshan; Palaniyandi, Senthilnathan; Clark, Cheryl; Nathan, Cherie-Ann O; Abreo, Fleurette W; Caldito, Gloria

2011-10-01

The eukaryotic translation initiation factor 4E (eIF4E) in conjunction with its binding protein, 4EBP1, regulates the translation of cap-dependent mRNAs. An aberrant increase in eIF4E shifts the balance in favor of translation of transcripts that promote cell proliferation and malignancy. eIF4E protein is commonly elevated in head and neck squamous cell carcinomas (HNSCC), and its overexpression is associated with increased recurrence. An underlying mechanism for eIF4E overexpression is gene amplification, and we wanted to determine whether eIF4E mRNA could serve as a prognostic maker of HNSCC. Tumor specimens from 26 HNSCC patients and oral tissues from 17 control subjects were examined for eIF4E and 4EBP1 by semiquantitative RT-PCR and correlated with clinical and pathologic findings. Unlike eIF4E mRNA alone, expression of eIF4E relative to 4EBP1 was a more precise predictor of HNSCC and its progression (P < .01, Wilcoxon rank sum test). Eight of 26 patients (31%) had elevated eIF4E:4EBP1 (4E:4EBP1; >25), and 7 of these (87.5%) had recurrence. Alternately, from 18 patients with low 4E:4EBP1 (<25; 69%), only 5 patients had recurrence (30.1%). To determine the probability of no recurrence, Kaplan-Meier analysis showed significantly poor disease-free survival in patients with elevated 4E:4EBP1 than those with low ratios (P < .01, log rank test). Elevated 4E:4EBP1 significantly correlated with increased disease recurrence. Because 4EBP1 modulates eIF4E activity, our results highlight the importance of incorporating a joint analysis of eIF4E and 4EBP1 mRNAs in HNSCC patient care decisions. Copyright © 2011 The American Laryngological, Rhinological, and Otological Society, Inc.

Computer Automated Ultrasonic Inspection System

DTIC Science & Technology

1985-02-06

Reports 74 3.1.4 Statistical Analysis Capability 74 3.2 Nondestructive Evaluation Terminal Hardware 76 3.3 Nondestructive Evaluation Terminal Vendor...3.4.2.6 Create a Hold Tape 103 vi TABLE OF CONTENTS SECTION PAGE 3.4.3 System Status 104 3.4.4 Statistical Analysis 105 3.4.4.1 Statistical Analysis...Data Extraction 105 3.4.4.2 Statistical Analysis Report and Display Generation 106 3.4.5 Quality Assurance Reports 106 3.4.6 Nondestructive Inspection

Military Justice Study Guide

DTIC Science & Technology

1990-07-01

Intrusions for valid medical purposes 4-20 G. Inspections and inventories 4-21 1. General considerations 4-21 2. Inspections 4-21 3. Inventories 4-23...4-25 4. Valid medical purpose 4-25 5. Fitness-for-duty testing 4-26 a. Command-directPd testing 4-26 b. Aftercare and surveillance testing 4-26 c...that the convening authority assign a medical , scientific or other expert to assist in the preparation of the defense case. Once assigned, the expert

48 CFR 401.301 - Policy.

Code of Federal Regulations, 2014 CFR

2014-10-01

... (mission area). 4E Food Safety and Inspection Service. 4F [Reserved] 4G Forest Service. 4H [Reserved] 4I Natural Resources Conservation Service. 4J [Reserved] 4K Food and Nutrition Service. 4L Animal and Plant...

48 CFR 401.301 - Policy.

Code of Federal Regulations, 2012 CFR

2012-10-01

... (mission area). 4E Food Safety and Inspection Service. 4F [Reserved] 4G Forest Service. 4H [Reserved] 4I Natural Resources Conservation Service. 4J [Reserved] 4K Food and Nutrition Service. 4L Animal and Plant...

48 CFR 401.301 - Policy.

Code of Federal Regulations, 2013 CFR

2013-10-01

... (mission area). 4E Food Safety and Inspection Service. 4F [Reserved] 4G Forest Service. 4H [Reserved] 4I Natural Resources Conservation Service. 4J [Reserved] 4K Food and Nutrition Service. 4L Animal and Plant...

Pegram Nuclear Physics Laboratories Progress Report for January 1969 through December 1969 to the United States Atomic Energy Commission

DTIC Science & Technology

1969-12-01

1 +1 4J. Lr) x 0 ra4 -4 Lr) C1 U4)) -I Cd Cd -1 ~ 0 r-4 Nn 0 >- C N u ~~~) +1 +1 +1 ct w +1 a) 0O u 4.-44- L"A ~ - r-5- a) Ln Ln) o +1 +1 +1 + 10 b4... 10 - 10 -7 seconds). These isomers have been observed and so were intermediate structures in the sub-threshold fission of 2 37Np, 2 34U etc., which...bo- Un n C4 1 . 0) 1.4 M) V4-1 aj ) t.) Eq 0 9d ’-4 ;:a. 0 U co 4- d H. 4) a) ,q a) 41 u 4J -rq a) ) .p4 (D 0 ’-4 o 0 D U)29. 10 1 1 Neutron TOF

All Prime Contract Awards by State or Country, Place, and Contractor. Part 20 (Fredericksburg Virginia-Springfield Virginia)

DTIC Science & Technology

1990-01-01

a * Vs 4 NN- 4IN 00 c -10 Ina 0004C r) 0 r-s ON I CC#0) ot in --4 (no ifl0.-4 0-400 0Vs 00-I 0000 -400 EEq -E tun 04 1 0C) 1 44 4 VI 0004 Vs4<WIL ax...am4- N zzzzzzzzzzzzzzzzzzzzzz Wc 1 4-4 & Zaw *hf Mel of- 4o So atO it NNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNSi 11 1a ~ S 44 0O HNNNNNNNNNNNNNNNNC...4. 4.-I 0 3C11 1 M (V) N1 00 -000c 1-00 0) 0) 0 0 0 000) 0 ə 1(IM C) N 00.i 0000.i CMM..i 00 00 02 >-M 0) >-00000.i 0) H I tUN NOIL 4C 0 4C w 4C 4 00

Platelets release CXCL4L1, a nonallelic variant of the chemokine platelet factor-4/CXCL4 and potent inhibitor of angiogenesis.

PubMed

Struyf, Sofie; Burdick, Marie D; Proost, Paul; Van Damme, Jo; Strieter, Robert M

2004-10-29

Platelet factor-4 (PF-4)/CXCL4 was the first chemokine described to inhibit neovascularization. Here, the product of the nonallelic variant gene of CXCL4, PF-4var1/PF-4alt, designated CXCL4L1, was isolated for the first time from thrombin-stimulated human platelets and purified to homogeneity. Although secreted CXCL4 and CXCL4L1 differ in only three amino acids, CXCL4L1 was more potent in inhibiting chemotaxis of human microvascular endothelial cells toward interleukin-8 (IL-8)/CXCL8 or basic fibroblast growth factor (bFGF). In vivo, CXCL4L1 was also more effective than CXCL4 in inhibiting bFGF-induced angiogenesis in rat corneas. Thus, activated platelets release CXCL4L1, a potent regulator of endothelial cell biology, which affects angiogenesis and vascular diseases.

National Dam Safety Program. Palmer Falls Dam, Upper Hudson River Basin, Saratoga and Warren Counties, New York. Phase I Inspection Report,

DTIC Science & Technology

1980-08-23

MA = -a a (A ILa 0. on 4 04 - 0 4.. 4i 44 4i . 4 4. PN w 4 - at AISA 4, 4. 4 ac I r V tvso l, -Vcp4pnfyw to &A0: 1. 0.V. 494 4...for Nuclear Power Plants, Regulating Guide 1.59, Revision 2, August1977 3. Linsley and Franzini: Water Resources Engineering, Second Edition , McGraw...Hill (1972) 4. W. Viessman, Jr., J. Knapp, G. Lewis, 1977, 2nd Edition , Introduction to Hydrology 5. Ven Te Chow: Handbook of Applied Hydrology, McGraw

New molecular assemblies of redox isomers, [CrIII(X4SQ)3-n(X4Cat)n]-n (X = Cl and Br; n = 0, 1, and 2), with metallocenium cations, [MIIICp2]+ (M = Co and Fe): X-ray crystal structures and physical properties.

PubMed

Chang, H C; Miyasaka, H; Kitagawa, S

2001-01-01

A series of redox isomers of [CrIII(X4SQ)(X4Cat)2]2-, [CrIII(X4SQ)2(X4Cat)]-, and [CrIII(X4SQ)3]0 (X = Cl and Br, SQ = semiquinonate, and Cat = catecholate) have been synthesized and characterized as charge-transfer (CT) compounds with metallocenium cations: (CoIIICp2)2[CrIII(Cl4SQ)(Cl4Cat)2] (1), (CoIIICp2)2[CrIII(Br4SQ)(Br4Cat)2] (2), (FeIIICp2)[CrIII(Cl4SQ)2(Cl4Cat)].C6H6 (4), (FeIIICp2)[CrIII(Br4SQ)2(Br4Cat)].CS2 (5), and (FeIIICp2)[CrIII(Cl4SQ)2(Cl4Cat)][CrIII(Cl4SQ)3] (6). First, the oxidation states of the chromium complexes are strongly dependent on the redox potentials of the metallocenes used. The CoIICp2, exhibiting stronger reduction power than FeIICp2, is useful for two-electron reduction of the [CrIII(X4SQ)3]0, affording [CrIII(X4SQ)(X4Cat)2]2- (1 and 2), which are first isolated and crystallographically characterized in the solid state. In contrast the reaction with FeIICp2 affords only [CrIII(X4SQ)2(X4Cat)]- (4 and 5). Second, solvents influence crystal structures of these compounds. The solvent set of C6H6/CS2 gives 1:1:C6H6 compound 4 with unique charged anions, [CrIII(Cl4SQ)2(Cl4Cat)]-, while the other set, n-C6H12/CS2, affords 1:2 compound 6 including the two redox isomers, [CrIII(Cl4SQ)2(Cl4Cat)]- and [CrIII(Cl4SQ)3]0. The [CrIII(X4SQ)(X4Cat)2]2- anions in 1 and 2 show no significant interconnection between them (discrete type), while the [CrIII(X4SQ)2(X4Cat)]- anions in 4-6 show one-dimensional column-type structures with the aid of intermolecular stacking interactions of the ligand moieties. The anions in 4 show additional stacking interaction with the [FeIIICp2]+ to form one-dimensional ...[D][A][S][D][A]... (D = [FeIIICp2]+, A = [CrIII(Cl4SQ)2(Cl4Cat)]-, and S = C6H6) type mixed-stack arrangements similar to that of previously reported (CoIIICp2)[CrIII(Cl4SQ)2(Cl4Cat)].C6H6 (3). Compound 6 forms a two-dimensional sheet structure where the two redox isomers, [CrIII(Cl4SQ)2(Cl4Cat)]- and [CrIII(Cl4SQ)3]0, are included. The sheet is regarded as a mixed-valence molecular assembly. Two types of the anions, [CrIII(X4SQ)(X4Cat)2]2- (1 and 2) and [CrIII(X4SQ)2(X4Cat)]- (4-6), exhibiting an intramolecular mixed-valence state, show intramolecular intervalence CT transition (IVCT) from the Cat to the SQ at near 5800 and 4300 cm-1, respectively, both in the solution and in the solid states. The intermolecular mixed-valence state of 6 was characterized by absorption spectroscopy, electric conductivity, and SQUID magnetometry. Interestingly, this mixed-valence state of the chromium module is dependent on the redox active nature of the coordinated ligands.

76 FR 27281 - Airworthiness Directives; Dowty Propellers Type R212/4-30-4/22 and R251/4-30-4/49 Propeller...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-05-11

... Airworthiness Directives; Dowty Propellers Type R212/4-30-4/22 and R251/4-30-4/49 Propeller Assemblies AGENCY.../22 propeller assemblies with hub and driving center assembly part number (P/N) 601022105, 601022211, 601022294, 601021426, 601021858, or 601021859 installed, and type R251/4-30-4/49 propeller assemblies with...

76 FR 19724 - Airworthiness Directives; Airbus Model A300 B4-600, B4-600R, and F4-600R Series Airplanes, and...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-04-08

... B4-600, B4-600R, and F4-600R Series Airplanes, and Model C4-605R Variant F Airplanes (Collectively... F4-605R and F4-622R airplanes, and Model A300 C4-605R Variant F airplanes; and Model A310-203, -204...

Syntheses, structural variants and characterization of AInM′S{sub 4} (A=alkali metals, Tl; M′ = Ge, Sn) compounds; facile ion-exchange reactions of layered NaInSnS{sub 4} and KInSnS{sub 4} compounds

DOE Office of Scientific and Technical Information (OSTI.GOV)

Yohannan, Jinu P.; Vidyasagar, Kanamaluru, E-mail: kvsagar@iitm.ac.in

Ten AInM′S{sub 4} (A=alkali metals, Tl; M′= Ge, Sn) compounds with diverse structure types have been synthesized and characterized by single crystal and powder X-ray diffraction and a variety of spectroscopic methods. They are wide band gap semiconductors. KInGeS{sub 4}(1-β), RbInGeS{sub 4}(2), CsInGeS{sub 4}(3-β), TlInGeS{sub 4}(4-β), RbInSnS{sub 4}(8-β) and CsInSnS{sub 4}(9) compounds with three-dimensional BaGa{sub 2}S{sub 4} structure and CsInGeS{sub 4}(3-α) and TlInGeS{sub 4}(4-α) compounds with a layered TlInSiS{sub 4} structure have tetrahedral [InM′S{sub 4}]{sup −} frameworks. On the other hand, LiInSnS{sub 4}(5) with spinel structure and NaInSnS{sub 4}(6), KInSnS{sub 4}(7), RbInSnS{sub 4}(8-α) and TlInSnS{sub 4}(10) compounds with layered structuremore » have octahedral [InM′S{sub 4}]{sup −} frameworks. NaInSnS{sub 4}(6) and KInSnS{sub 4}(7) compounds undergo facile topotactic ion-exchange, at room temperature, with various mono-, di- and tri-valent cations in aqueous medium to give rise to metastable layered phases. - Graphical abstract: NaInSnS{sub 4} and KInSnS{sub 4} compounds undergo, in aqueous medium at room temperature, facile topotactic ion-exchange with mono, di and trivalent cations. Display Omitted - Highlights: • Ten AInM′S{sub 4} compounds with diverse structure types were synthesized. • They are wide band gap semiconductors. • NaInSnS{sub 4} and KInSnS{sub 4} compounds undergo facile topotactic ion-exchange at room temperature.« less

DOE Office of Scientific and Technical Information (OSTI.GOV)

Sekiyama, Naotaka; Arthanari, Haribabu; Papadopoulos, Evangelos

The eIF4E-binding protein (4E-BP) is a phosphorylation-dependent regulator of protein synthesis. The nonphosphorylated or minimally phosphorylated form binds translation initiation factor 4E (eIF4E), preventing binding of eIF4G and the recruitment of the small ribosomal subunit. Signaling events stimulate serial phosphorylation of 4E-BP, primarily by mammalian target of rapamycin complex 1 (mTORC1) at residues T 37/T 46, followed by T 70 and S 65. Hyperphosphorylated 4E-BP dissociates from eIF4E, allowing eIF4E to interact with eIF4G and translation initiation to resume. Because overexpression of eIF4E is linked to cellular transformation, 4E-BP is a tumor suppressor, and up-regulation of its activity is amore » goal of interest for cancer therapy. A recently discovered small molecule, eIF4E/eIF4G interaction inhibitor 1 (4EGI-1), disrupts the eIF4E/eIF4G interaction and promotes binding of 4E-BP1 to eIF4E. Structures of 14- to 16-residue 4E-BP fragments bound to eIF4E contain the eIF4E consensus binding motif, 54YXXXXLΦ 60 (motif 1) but lack known phosphorylation sites. We report in this paper a 2.1-Å crystal structure of mouse eIF4E in complex with m 7GTP and with a fragment of human 4E-BP1, extended C-terminally from the consensus-binding motif (4E-BP1 50–84). The extension, which includes a proline-turn-helix segment (motif 2) followed by a loop of irregular structure, reveals the location of two phosphorylation sites (S 65 and T 70). Our major finding is that the C-terminal extension (motif 3) is critical to 4E-BP1–mediated cell cycle arrest and that it partially overlaps with the binding site of 4EGI-1. Finally, the binding of 4E-BP1 and 4EGI-1 to eIF4E is therefore not mutually exclusive, and both ligands contribute to shift the equilibrium toward the inhibition of translation initiation.« less

All Prime Contract Awards by State or Country, Place, and Contractor. Part 21 (Stafford Virginia-Yellowstone Park)

DTIC Science & Technology

1990-01-01

40000 -loco � 000 00"e00000 a Ir-4 N 4 c 40~C) ,0oe c c C)CV V CV C-i-4 caninannananmwa m wnan W* IC04N4 U Ncv ~f0cv(’)mmma) ’. -4-4-4-4-1 *4NN .0...MC’) U N 40 N C’) Ncv ) 0 -IN ON ON C0 0-44.-I- ON0 : cc 04) U C’) -I 04. OP. NO4.0 0-I N4. I--Cv) Vq44.4..4. 644 m : a 4) -I 00 ao -4.40 M a -40 00...IZ .- JvvvZ IW NCV 8 Nl P.C c’S r 0P r-0 P. P.- 0r 4W5 0>3ON -IN -N OV)N NN O-NN -IN NN OIN ONNNNNNN .8 .c co 04 C4 O( I 04W Nz z z zz z zz z zz z z zz

Prince George Apt, British Columbia, Canada, Revised Uniform Summary of Surface Weather Observations (RUSSWO). Parts A-F.

DTIC Science & Technology

1971-11-02

59. "i5 Jb ,++ 5 ), 4, 7_0+1,7:e 1 , 𔃻 0 3500 T7 j .l 1 61..4 62.r’ 62.2 i . . ..? I . 4,2 ’.’’ 3 Z 1.4 -i 300 .I’e i~, d. 4 64.6 6.5, I t 5,9 66 .5j...8217 .4 5. 8) 0800 4 . L4 84.4 114 . 94ol 94. ,9 83,3 135 8. .6. -, ~6i M~ S500 74 14.0 .) i .) 86 86 13 ob e601 87*0 87,4l 76 7.8 tfId d A8.4 hh , * 5...34 5 i.4 U07000 4.* 04. 64 .5 04 04*5 Ř,05 4 ) L 6 J 4 4 5 It do.J 64 .5 64. t’ 4 5 t’. ’- i 14 I’., 0 6000 3,.:s hh ,5 SAeO 6F.6 68,96 61 .,6 6

Models for the Aerosols of the Lower Atmosphere and the Effects of Humidity Variations on their Optical Properties

DTIC Science & Technology

1979-09-20

PSi NEN.4 0 0i Si -t .4 It 4D NN 16*. * 4 . M% 0 NU% .Ir. N ’ .0 41% a E D 0. P.4 0 .. 4 ’A a4 4% 9 4 44 P 4s C’ r) Ai N U% IAN 40 U’ 0u4 i’ Ný .4 .4...1128101 1 1901 9 AI I I goo-I 1 4M-I SC*Ti*Lle PARAM1ETE .ff@ 1.66911*66 1*9911-01 1090619-01 .0407 .7773 sole 90119-1-1 809011-11 1.4761-01 all...2.9.1H-02 1.9611-01 1.6631-01 .666 .23 .3.75 2.5071-0? 1.103S-01 9..774E-02 . 65292 .12 4.0 23.9-19.0511-0 6.4p9E-%32 *.24#4 .66 1.0 1931-02 1.2.01S-03

Department of the Army Justification of Estimates for FY 1991 Submitted to Congress January 1990. Operation and Maintenance, Army Justification Book. Volume 1

DTIC Science & Technology

1990-01-01

8217 - ’"I Si _ Cr ~J-1 IL tJ -4; 4* V -) a- Nii :1-1 N - *~- ~ - - Flh 31 - ’,- I - , - 241 m -18 ’TNJN V _, ZA- E -t 4 3R 2 u : aF - - *>- -- Lj 0 00...0J~ . -4 4. C C rn~ 00. m * a ) ca Z4 :) af -4 4j Z. Ci o a) rn C.) to ~L C"W.o ) ) u) /3 0 MJ 0 r_4-4- 4-j go u 0 a0 W >to-44L-Ui 4-CJ J4 4J u) u~ E...t J m w-0~ w ~ 0 Z z~ 0 to u wm D m. -X 00’> Q) -~ U cn .- 1~. - 0 Uf.- 0> u0 -j t >C - cn uu 4z vC*-4J mu4- w v Ř-J W~c w w w wCCu ’ Af ~-a ju 0 0 z

[Cochinchinenin--a new chalcone dimer from the Chinese dragon blood].

PubMed

Zhou, Z H; Wang, J L; Yang, C R

2001-03-01

To study the active constituents of Dracaena cochinchinensis (Lour.) S.C. Chen. in the commercial dragon blood. Various column chromatographies with Sephadex L-20 gel, MCI gel and silica gel were employed for the isolation and purification. The structures of compounds were elucidated by spectral analysis. Nine chalcones were isolated from the commercial dragon's blood which was made of D. cochinchinensis (Lour.) S.C. Chen.. By means of spectral data, they were identified as 1-[5-(2,4,4'-trihydroxydihydrochalconyl)]-1- (p-hydroxyphenyl)-3-(2-methoxy-4-hydroxy-phenyl)-propane (1), 2'-methoxysocotrin-5'-ol (2), socotrin-4'-ol (3), 2-methoxy-4, 4'-dihydroxydihydrochalcone (4), 2, 4, 4'-trihydroxy-dihydrochalcone (5), 2, 4, 4'-trihydroxy-6-methoxydihydrochalcone (6), 2', 4', 4-trihydroxychalcone (7), 2-methoxy-4, 4'-dihydroxychalcone (8) and 2'-methoxy-4', 4-dihydroxychalcone (9). Compound 1 is a new chalcone dimer and named as cochinchinenin. Compounds 2-9 were isolated from D. cochinchinensis (Lour.) S.C. Chen. for the first time.

Electrical Resistivity of Chromium, Cobalt, Iron, and Nickel.

DTIC Science & Technology

1982-06-01

V * E ; u to 1 0 .’ 0 1 In m .10 U~0 40..- 4 4 a U -- W r 00 r1 C0 1a 1 0 0 . 441 1 -41 W 00 0 .40 0 0 ’cc 0 41 1.4 08 0𔃻 all . 0 41 051 " 0 - 4...0- .C w T . f Q4 0 if n ~ w bc 0. 41. m4~i 04 0’ if 00 Ŕ 0 t ’ 0 e ToC c. . C:-04 . 4 4 f .- . i 0.00 0’ *if’-𔃺. 0 0 a, C.) ) 0 , u 0 cx - v CA M...8217 az a a c -P 0 4.4 4.. 1 4..4. 4-* U on 40. r4 r.C . 3.4.1. OD * 0 OUD 0 4 27 0 0 E .. 0. j en 1. 00 0% w ’A 0. 00 v .1 - I 1 10. 0 Q en CL 9: 41 a

NORDA Bench Mark Package Document.

DTIC Science & Technology

1980-04-30

CL0 au a 0 m a am ac at1 0 074 or40 0:4 0 4 074 07 a? 02 co cc a a a0 a , a aL a a a aC a a .................ra................~lama...........w.12...1j *g at * a 0o c a lza 3 Al f" 00 N4 a4 4u Na ma LA NN &AA 0 jJ, MO 14MO N 0 4P 0a aO 04 4x4 .. z N 00 0 N0 me-A 4" a -a It 4:_ 4 tcp . 04 . . . . .0...L.~ .~ ~.J I- U .4- C IV-8 A .1~ . -a-- 7L CL ±L 4 LU A - a.. LA I ’ I2 j aa c a- zo aL 4a oc a~i a Al 4 -~ 2A1 h4~~~~ V1 M0 C 4T@0 C 00.o@ e C

Electron induced ionization of plasma processing gases: C4F x (x  =  1–8) and the isomers of C4F6 and C4F8

NASA Astrophysics Data System (ADS)

Gupta, Dhanoj; Choi, Heechol; Kwon, Deuk-Chul; Yoon, Jung-Sik; Song, Mi-Young

2018-04-01

The total ionization cross section (Q ion) for C4F x (x  =  1–8) fluorocarbons and the isomers of C4F6 and C4F8 molecules are calculated from ionization threshold to 5 keV using the binary-encounter bethe method. The targets are fully optimized using the Hartree–Fock (HF) method and density function theory (DFT) for their minimum energy structure and orbital parameters. The present Q ion with HF parameters showed good agreement with the experimental data for 1,3-C4F6, 2-C4F6, 2-C4F8 and 1-C4F8. On the other hand, the Q ion with DFT parameters are in good accordance with the recent theoretical results for 1,3-C4F6 and 2-C4F6. The Q ion for c-C4F8 showed much variation among the various results. The isomer effect in Q ion is negligible for the isomers of C4F6 and C4F8 molecules. The calculation of Q ion for C4F, C4F2, C4F3, C4F4, C4F5, c-C4F6, C4F7 and iso-C4F8 is a maiden attempt. The present cross section data are important quantities for low temperature plasma modeling especially related to the fluorocarbon plasmas.

Protein Kinase Mitogen-activated Protein Kinase Kinase Kinase Kinase 4 (MAP4K4) Promotes Obesity-induced Hyperinsulinemia.

PubMed

Roth Flach, Rachel J; Danai, Laura V; DiStefano, Marina T; Kelly, Mark; Menendez, Lorena Garcia; Jurczyk, Agata; Sharma, Rohit B; Jung, Dae Young; Kim, Jong Hun; Kim, Jason K; Bortell, Rita; Alonso, Laura C; Czech, Michael P

2016-07-29

Previous studies revealed a paradox whereby mitogen-activated protein kinase kinase kinase kinase 4 (Map4k4) acted as a negative regulator of insulin sensitivity in chronically obese mice, yet systemic deletion of Map4k4 did not improve glucose tolerance. Here, we report markedly reduced glucose-responsive plasma insulin and C-peptide levels in whole body Map4k4-depleted mice (M4K4 iKO) as well as an impaired first phase of insulin secretion from islets derived from M4K4 iKO mice ex vivo After long-term high fat diet (HFD), M4K4 iKO mice pancreata also displayed reduced β cell mass, fewer proliferating β cells and reduced islet-specific gene mRNA expression compared with controls, although insulin content was normal. Interestingly, the reduced plasma insulin in M4K4 iKO mice exposed to chronic (16 weeks) HFD was not observed in response to acute HFD challenge or short term treatment with the insulin receptor antagonist S961. Furthermore, the improved insulin sensitivity in obese M4K4 iKO mice was abrogated by high exogenous insulin over the course of a euglycemic clamp study, indicating that hypoinsulinemia promotes insulin sensitivity in chronically obese M4K4 iKO mice. These results demonstrate that protein kinase Map4k4 drives obesity-induced hyperinsulinemia and insulin resistance in part by promoting insulin secretion from β cells in mice. © 2016 by The American Society for Biochemistry and Molecular Biology, Inc.

Worldwide Manpower Distribution by Geographical Area, Third Quarter, FY-82.

DTIC Science & Technology

1982-06-30

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The Meal, Ready-to-Eat Consumed in a Cold Environment

DTIC Science & Technology

1990-02-23

9 58 Beef, Diced with Gravy 1/4 1/2 3/4 1 2 1 2 3 4 5 6 7 B 9 59 Chicken a la King 1/4 1/2 3/4 1 2 1 2 3 4 5 6 7 8 9 60 Meatballs with BBQ Sauce 1/4...W LGRAVY- CHICKEN A LA KING- MEATBALLS W/BBQ SAUCE- BEEF GROUND W/SPICED SAUCE- STARCHES- BEANS IN TOMATO SAUCE- C> ~ ~ ( H )()-CQb) CRACKERS- S...2 3/4 1 Chicken a la King 60 1/4 1/2 3/4 1 Meatballs with BBQ Sauce 61 1/4 1/2 3/4 1 Ham Slices 62 1/4 1/2 3/4 1 Beef Ground with Spiced Sauce

Anthropometry of Women of the U.S. Army - 1977. Report No. 5 - Comparative Data for U.S. Army Men

DTIC Science & Technology

1977-07-01

75-109.75 18 147 6.27 51922 74.75- 75#70 26 162 9e06 5299b 10?7S-1d8.75 22 129 7.67 44.95 73.75- 74*7:P 2? 126 3.41 43.90 1ab *?$-t~f.75 18 107 6.27...00 P4, " d L5 a .4. eI- uid 0 * (A C3 (4 %a t 4 W4* N 4 4M v4 N 4 1 -4 𔃺 Z O Nr. N I.- udA V- 4 . 02 Lz V5 aA N.4 4 N N f M A V4 Ps (A :." Id -AAi

Soluble FGFR4 extracellular domain inhibits FGF19-induced activation of FGFR4 signaling and prevents nonalcoholic fatty liver disease

DOE Office of Scientific and Technical Information (OSTI.GOV)

Chen, Qiang; The First Affiliated Hospital of Xiamen University, Xiamen; Jiang, Yuan

2011-06-17

Highlights: {yields} Soluble FGFR4 extracellular domain (FGFR4-ECD) was effectively expressed. {yields} FGFR4-ECD inhibited FGF19-induced activation of FGFR4 signaling. {yields} FGFR4-ECD reduced palmitic acid-induced steatosis of HepG2 cells. {yields} FGFR4-ECD reduced tetracycline-induced fatty liver in mice. {yields} FGFR4-ECD partially restored tetracycline-repressed PPAR{alpha} expression. -- Abstract: Fibroblast growth factor receptor 4 (FGFR4) is a transmembrane tyrosine kinase receptor that plays a crucial role in the regulation of hepatic bile acid and lipid metabolism. FGFR4 underlies high-fat diet-induced hepatic steatosis, suggesting that inhibition of FGFR4 activation may be an effective way to prevent or treat nonalcoholic fatty liver disease (NAFLD). To determine whethermore » neutralization of FGFR4 ligands by soluble FGFR4 extracellular domain (FGFR4-ECD) can inhibit the activation of FGFR4, we constructed FGFR4-ECD expression vector and showed that FGFR4-ECD was effectively expressed in cells and secreted into culture medium. FGFR4-ECD inhibited FGF19-induced activation of FGFR4 signaling and reduced steatosis of HepG2 induced by palmitic acid in vitro. Furthermore, in a tetracycline-induced fatty liver model, expression of FGFR4-ECD in mouse liver reduced the accumulation of hepatic lipids and partially restored the expression of peroxisome proliferator-activated receptor {alpha} (PPAR{alpha}), which promotes the mitochondrial fatty acid beta-oxidation but is repressed by tetracycline. Taken together, these results demonstrate that FGFR4-ECD can block FGFR4 signaling and prevent hepatic steatosis, highlighting the potential value of inhibition of FGFR4 signaling as a method for therapeutic intervention against NAFLD.« less

Structure and properties of the anions MF4-, MCl4- and MBr4- (M = C, Si, Ge)

NASA Astrophysics Data System (ADS)

Grein, Friedrich

2015-04-01

Density functional theory (DFT), Møller-Plesset (MP2) and coupled cluster with single and double substitutions including non-iterative triple excitations (CCSD(T)) calculations on the anions MX4-, with M = C, Si, Ge and X = F, Cl, Br, show that GeF4-, SiCl4-, GeCl4- and SiBr4- prefer a C2v conformation, but CCl4- is an elongated C3v structure. CBr4- has Td symmetry in MP2, but is slightly more stable in elongated C3v form with DFT and CCSD(T). GeBr4- has Td symmetry. CF4- and SiF4- are unstable with respect to loss of an electron. Vertical electron affinities (EAs) are negative also for CCl4 and SiCl4, and close to zero for GeF4 and SiBr4. Adiabatic EAs range from 0.47 eV for SiCl4 to 1.78 eV for GeBr4. The lowest excited states at Td symmetry are 2T2 resonances with energies of 2.1-3.5 eV, resulting from excitation of the a1 singly occupied molecular orbital to vacant t2 orbitals. Vertical excitation energies (VEEs) and vibrational frequencies are given for the most stable anionic geometries. Comparison with experimental VEEs for CCl4- is made. From dissociation energies of MX4, MX4-, MX3 and MX3-, appearance energies of X-, MX3-, X2- and MX2- were calculated. Most were found to be in reasonable agreement with experimental values. Theoretical spin densities and g-factors have been compared with experimental results available for CCl4-, SiCl4- and GeCl4-.

Recent Advances in the Chemistry of Condensed Tannins

Treesearch

Richard W. Hemingway; Gerald W. McGraw; J.J. Karchesy; L.Y. Foo; L.J. Porter

1983-01-01

The presence of the procyanidins epicatechin-(4β-8)-catechin, epicatechin-{4β-6)-catechin, catechin-(4α-8)-catechin, epicatechin-(4β-8)-epicatechin-(4β-8)-catechin, epicatechin-(4β-6)-epicatechin-(4β-8)-catechin, and epicatechin-(4β-8)-epicatechin-(4β-6)catechin in tile phloem of ...

10 CFR 960.4-2-4 - Climatic changes.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 10 Energy 4 2010-01-01 2010-01-01 false Climatic changes. 960.4-2-4 Section 960.4-2-4 Energy DEPARTMENT OF ENERGY GENERAL GUIDELINES FOR THE PRELIMINARY SCREENING OF POTENTIAL SITES FOR A NUCLEAR WASTE REPOSITORY Postclosure Guidelines § 960.4-2-4 Climatic changes. (a) Qualifying condition. The site shall be...

An Economic Model of Future Coal/Densified Refuse-Derived Fuel Use at Wright-Patterson AFB, Ohio.

DTIC Science & Technology

1981-09-01

9118 21.5 18.7 27.0 7.5 21 Jul 7845 17.9 23.3 23.5 4.4 22 Jul 9345 18.3 22.2 18.2 15.2 23 Jul 7922 15.9 8.9 19.8 14.0 24 Jul 8177 21.3 18.7 21.2 16.5...40 0 P- 41 40 %0 Ch 0 .) 0 A0 $4 r. UU W - 4 C’f -W .1 H4 IV𔃾 .r44 448 ot (a0 (’ e 4 0 r- :j 4.) r-f t- o: 0n to N .. IU) 4.1 41 N 1 *, tS% H-. to...4J . t 4) 9 1 4 4)0 Ch M oa𔃾 03 Ř A*r04 ’.10 U) o 0 tv 00 .A tn a Ln U1 J Sl:3 to LA 4)r- rz4IL~o-~’.4J $r- ’ 4) -I r. N4 o I~% r ’.~r-4 to * *l * 0

Alpha List of Prime Contract Awards. Oct 92-Sep 93. FY93. (Oank8 Elbelco Inc. - Food Service Decor & Design). Part 7

DTIC Science & Technology

1994-03-01

In = 4j 1 wow 11 (A com L) w U U) 04 ý4 0 u Ce ý4 0 0 Cie 0 Ix rý 00 .4 L) cc W 0 N C I cc" If x Q-J(Doý- x q1t (D 0 xooooý-- 0 L) 0 0 ý- CL. 0 m Ln...oCGoCOCO CON CN w 4 < 0 44 < O44 M -cvMN U (COO0-40(11 .-40 -40 OCOCCID(O 040 00W 04 NU) COM -i -444 0 N 0-4 if U.. a: a Ezz Z z 0 In0 000 a CV (0() 3n U4... coM 4)(4W-4 sN UN u m 4 - W gn N I 004- If > tcI Ny.4 -4 of0 X.4 cc (a 000000000001111111111Q0 N a I 004o- N1 as 4- -40-4 .4 -4 0 No tl 00 0

Alpha List of Prime Contract Awards. Oct 92-Sep 93. FY93. (HSU Ronald Construction Co. - Jacobson & Son Yard Service). Part 10

DTIC Science & Technology

1994-03-01

WCo toJ Il I OOt 0 CL I I 004*LaJ 11 On 11W 00t) II o4 4 4 4 4 ov4 44 4 4 4 444 44 If 00’E01 M൴ 44 44 114 COM it L)UUUUNN 440 4000000 00. NON NI N44...N E I-I 1 0CDO II-.00-40000000 0000000-. 000-. 00 00040 0-.40 U:1-0C)C V V f)0C)mMC v V mI M M0V II CNNN Nr)NMC) YC V ) N NV4 C)M Y MmM Mm0il I Com 2...4- --N4-4 -4.MM-4 -4.ý -4 11 100I 00 P (0.-00iNDOmr. -QDO coM L i i i i i iN i(D 00L0 D(D i(00000MM NM Mr fMMr. M 0MMr.%WO 0W 0aW 11 -4 (0 0 II-cj 1 a

Prime Contract Awards by State or Country, Place and Contractor. Part 9 (Dundalk, Maryland - Roseville, Michigan), FY1991

DTIC Science & Technology

1991-01-01

0 0 0 400 100 C 0 00 C* -I 04 U )L - )IN ) IL OOOOOON S. N N N N N N NN-N * L).-I.-4 zzzzz2zzzzZZ 2 Z 2 2 ZZ zzz U-I 0-m MI4444444 0 N N 00C4o<N 0NI0...1 Co-I me WL-4 -4--4-44-4 -4 -4 -4-4 -4 -4 W40 (1N 1-0 -4.1 I-aInan CL.-IC) ne me A2 I o- - 100 00.- me D.. o o 00 0 o oo0oo00o 0 &)0 A (no 40, aO o0...oln o-4)- 411 U)0. In). 10 InI n ca if d I N w ~ (D< a4C N 4 M0 3 4 0 4- I3l 44 XCi X’ c"Il _C44 a-I 0Cl M-i ’in if 100 - -2 N D 00 1- 0 1-) 1 00 1

Synthesis of three new thiophene condensed pyrene derivatives, crystal structure and evaluation of their photophysical properties

NASA Astrophysics Data System (ADS)

Moriguchi, Tetsuji; Yakeya, Daisuke; Tsuge, Akihiko; Jalli, Venkataprasad

2018-04-01

Three new thiophene condensed fluorescent pyrene derivatives have been synthesized by a two-step process, via. Wittig reaction followed by iodine promoted photocyclization. These molecules have been characterized by 1H NMR and EI-MS. Further, the molecular structures of 4a, 4b and 4c has been confirmed by single crystal X-ray diffraction analysis. The protons located in the fjord and cove-regions of molecules 4b and 4c showed downfield shifts of the protons. Molecule 4a crystallized under monoclinic system with space group P21/c, molecule 4b crystallized under monoclinic system with space group C2/c and the molecule 4c crystalized under triclinic system with space group P-1. Molecules 4a, 4b and 4c showed strong absorption maxima wavelengths at 305, 358 and 330 nm, respectively. The molar extinctinction coefficients (ε) of the compounds 4a, 4b and 4c indicated molecule 4c has better ability to absorb UV light, molecule 4b has better fluorescence intensity than molecule 4a and 4c.

Polystyrene Corrector Element Added to Existing Positive Acrytate for Simulator Collimator.

DTIC Science & Technology

1982-02-01

LLJ S ci n e n LA OLn LA )LnQ O O 8 C2 0 ... J in-4 V-4 -4 -4 CMcici0 Y f e wq ~ wL W U- 35 -4- Q - oq4 0r-.u a clJ m~iO f 0%C oCjrL)4 C.) 0 " I- rJC...Cj0Q P 0 w -4 4: U LA) """C (Jci -4 C~j CV) LI.I . . . . . . .I In cc Q m0 c~ wa uia o" LC o oCD l o C) % V Ln U)Ln Ln tAo 0 r- im .o r . . . ,. . .c...LA0-tw-L wL V) W 48 * 2 CA 0 4-A ’ nr . 0 -4r-4 -4 -I V- (%J 0~~~’ cOO qwL ,CjCiV4 J4 J .-C’ n r- 00 wq 4A -4 0 03. o n W n mmM- - . %D 1- " lkCC

Enzymic Dehalogenation of 4-Chlorobenzoyl Coenzyme A in Acinetobacter sp. Strain 4-CB1

PubMed Central

Copley, Shelley D.; Crooks, Gwen P.

1992-01-01

4-Chlorobenzoate degradation in cell extracts of Acinetobacter sp. strain 4-CB1 occurs by initial synthesis of 4-chlorobenzoyl coenzyme A (4-chlorobenzoyl CoA) from 4-chlorobenzoate, CoA, and ATP. 4-Chlorobenzoyl CoA is dehalogenated to 4-hydroxybenzoyl CoA. Following the dehalogenation reaction, 4-hydroxybenzoyl CoA is hydrolyzed to 4-hydroxybenzoate and CoA. Possible roles for the CoA moiety in the dehalogenation reaction are discussed. PMID:16348702

75 FR 6702 - Notice of Realty Action: Recreation and Public Purposes Act Classification, California

Federal Register 2010, 2011, 2012, 2013, 2014

2010-02-10

... provisions of the Recreation and Public Purposes Act (R&PP Act), as amended, approximately 133 acres of... Meridian T. 16 N., R. \\1/4\\ E., Sec. 1, portion of W\\1/2\\SE\\1/4\\; Sec. 12, portions of NW\\1/4\\NE\\1/4\\, E\\1/2\\NW\\1/4\\, E\\1/2\\SW\\1/ 4\\, and SW\\1/4\\SW\\1/4\\; Sec. 13, portions of W\\1/2\\NW\\1/4\\ and NW\\1/4\\SW\\1/4...

Fabrication and Luminescence Characterization of a Silica Nanomatrix Embedded with NaYF4:Yb:Er:Tm@NaGdF4/Fe3O4 Nanoparticles

NASA Astrophysics Data System (ADS)

Thangaraju, Dheivasigamani; Santhana, Vedi; Matsuda, Satoshi; Hayakawa, Yasuhiro

2018-05-01

Hexagonal NaYF4:Yb:Er:Tm@NaGdF4 core-shell nanocrystals were synthesized using a seed mediated hot injection method, and monodispersed Fe3O4 (4 nm) nanoparticles were prepared from iron(II) actylacetonate by a precursor thermal decomposition method. Structural and morphology verified NaYF4:Yb:Er:Tm@NaGdF4 and Fe3O4 nanoparticles were utilized for the preparation of NaYF4:Yb:Er:Tm@NaGdF4/Fe3O4@SiO2 nanocomposite using a micro-emulsion method. Existence of Fe3O4 in NaYF4:Yb:Er:Tm@NaGdF4 in SiO2 nano-spheres were confirmed with transmission electron microscopy. Luminescence measurement revealed that NaYF4:Yb:Er:Tm@NaGdF4 exhibited strong emissions at green and red regions, in addition to a weak blue emission also observed under 980 nm excitation. Up-conversion emission of the nanoparticle-embedded silica nanocomposite showed that the up-conversion emission was not affected by Fe3O4 nanoparticles.

Production of complex rubidium and cesium hydrogen sulfate‒phosphates

DOE Office of Scientific and Technical Information (OSTI.GOV)

Komornikov, V. A., E-mail: v.a.kom@mail.ru; Grebenev, V. V.; Makarova, I. P.

2016-07-15

The solubility in the CsH{sub 2}PO{sub 4}‒CsHSO{sub 4}‒H{sub 2}O system at different temperatures (25, 50, and 75°C) is studied and the phase equilibria in the Rb{sub 3}H(SO{sub 4}){sub 2}‒RbH{sub 2}PO{sub 4}‒H{sub 2}O system under isothermal conditions (at 25°C) are analyzed. The temperature and concentration conditions for forming Rb{sub 2}(HSO{sub 4})(H{sub 2}PO{sub 4}), Rb{sub 4}(HSO{sub 4}){sub 3}(H{sub 2}PO{sub 4}), Cs{sub 4}(HSO{sub 4}){sub 3}(H{sub 2}PO{sub 4}), Cs{sub 3}(HSO{sub 4}){sub 2}(H{sub 2}PO{sub 4}), Cs{sub 2}(HSO{sub 4})(H{sub 2}PO{sub 4}), and Cs{sub 6}H(HSO{sub 4}){sub 3}(H{sub 2}PO{sub 4}){sub 4} compounds (the latter has been obtained for the first time) are determined. The conditions for growing largemore » single crystals of complex acid rubidium and cesium salts are found.« less

DOE Office of Scientific and Technical Information (OSTI.GOV)

Wang, Guangmei; Valldor, Martin; Mallick, Bert

Four open-framework transition-metal phosphates; (NH4)2Co3(HPO4)2F4 (1), (NH4)Co3(HPO4)2(H2PO4)F2 (2), KCo3(HPO4)2(H2PO4)F2 (3), and KFe3(HPO4)2(H2PO4)F2 (4); are prepared by ionothermal synthesis using pyridinium hexafluorophosphate as the ionic liquid. Single-crystal X-ray diffraction analyses reveal that the four compounds contain cobalt/iron–oxygen/fluoride layers with Kagomé topology composed of interlinked face-sharing MO3F3/MO4F2 octahedra. PO3OH pseudo-tetrahedral groups augment the [M3O6F4] (1)/[M3O8F2] layers on both sides to give M3(HPO4)2F4 (1) and M3(HPO4)2F2 (2–4) layers. These layers are stacked along the a axis in a sequence AA…, resulting in the formation of a layer structure for (NH4)2Co3(HPO4)2F4(1). In NH4Co3(HPO4)2(H2PO4)F2 and KM3(HPO4)2(H2PO4)F2, the M3(HPO4)2F2 layers are stacked along the a axismore » in a sequence AAi… and are connected by [PO3(OH)] tetrahedra, giving rise to a 3-D open framework structure with 10-ring channels along the [001] direction. The negative charges of the inorganic framework are balanced by K+/NH4+ ions located within the channels. The magnetic transition metal cations themselves form layers with stair-case Kagomé topology. Magnetic susceptibility and magnetization measurements reveal that all four compounds exhibit a canted anti-ferromagnetic ground state (Tc = 10 or 13 K for Co and Tc = 27 K for Fe) with different canting angles. The full orbital moment is observed for both Co2+ and Fe2+.« less

MS4a4B, a CD20 homologue in T cells, inhibits T cell propagation by modulation of cell cycle.

PubMed

Xu, Hui; Yan, Yaping; Williams, Mark S; Carey, Gregory B; Yang, Jingxian; Li, Hongmei; Zhang, Guang-Xian; Rostami, Abdolmohamad

2010-11-01

MS4a4B, a CD20 homologue in T cells, is a novel member of the MS4A gene family in mice. The MS4A family includes CD20, FcεRIβ, HTm4 and at least 26 novel members that are characterized by their structural features: with four membrane-spanning domains, two extracellular domains and two cytoplasmic regions. CD20, FcεRIβ and HTm4 have been found to function in B cells, mast cells and hematopoietic cells respectively. However, little is known about the function of MS4a4B in T cell regulation. We demonstrate here that MS4a4B negatively regulates mouse T cell proliferation. MS4a4B is highly expressed in primary T cells, natural killer cells (NK) and some T cell lines. But its expression in all malignant T cells, including thymoma and T hybridoma tested, was silenced. Interestingly, its expression was regulated during T cell activation. Viral vector-driven overexpression of MS4a4B in primary T cells and EL4 thymoma cells reduced cell proliferation. In contrast, knockdown of MS4a4B accelerated T cell proliferation. Cell cycle analysis showed that MS4a4B regulated T cell proliferation by inhibiting entry of the cells into S-G2/M phase. MS4a4B-mediated inhibition of cell cycle was correlated with upregulation of Cdk inhibitory proteins and decreased levels of Cdk2 activity, subsequently leading to inhibition of cell cycle progression. Our data indicate that MS4a4B negatively regulates T cell proliferation. MS4a4B, therefore, may serve as a modulator in the negative-feedback regulatory loop of activated T cells.

Revision and extension to the analysis of the third spectrum of bromine: Br III

NASA Astrophysics Data System (ADS)

Jabeen, S.; Tauheed, A.

2015-03-01

The spectrum of doubly ionized bromine (Br III) has been investigated in the vacuum ultraviolet wavelength region. Br2+ is an As-like ion with ground configuration of 4s24p3, thus a 3-electron system possessing a complex structure. The theoretical prediction was made using Cowan's quasi-relativistic Hartree-Fock code with superposition of configurations involving the 4s4p4, 4s24p2 (4d+5d+6d+5s+6s+7s), 4s4p3 (5p+4f), 4p4(4d+5s), 4s24p5s5p, 4s4p2 (4d2+5s2), 4s4p24f2 configurations for the even parity matrix and the 4s24p3, 4s24p2 (5p+6p+4f+5f) configurations for the odd parity matrix. Several previously reported levels of Br III have been revised, and new configurations have been added to the analysis. The spectrum used for this work was recorded on a 3-m normal incidence spectrograph in the wavelength region of 400-1326 Å using a triggered vacuum spark source. One hundred and two energy levels belonging to the 4s24p3, 4s4p4, 4s24p2 (4d+5d+6d+5s+6s +7s) configurations have been established, eighty-six being new. Two hundred and seventy-eight lines have been identified in this spectrum. The accuracy of our wavelength measurements for sharp and unblended lines is ±0.006 Å. The ionization potential of Br III was found to be 281,250±100 cm-1 (34.870±0.012 eV).

77 FR 19925 - Upland Cotton Base Quality

Federal Register 2010, 2011, 2012, 2013, 2014

2012-04-03

...\\-inch, leaf 3, (micronaire 3.5 through 3.6 and 4.3 through 4.9, strength 25.5 through 29.4 grams per tex..., (micronaire 3.5 through 3.6 and 4.3 through 4.9, strength 25.5 through 29.4 grams per tex, length uniformity... 4, (micronaire 3.5 through 3.6 and 4.3 through 4.9, strength 25.5 through 29.4 grams per tex, length...

19 CFR 178.2 - Listing of OMB control numbers.

Code of Federal Regulations, 2014 CFR

2014-04-01

... inward manifests 1515-0142 § 4.7a(c)(4) Transportation manifest (cargo declaration) 1651-0001 §§ 4.7b, 4... Container status messages §§ 4.10, 4.16, 4.30, 4.37, 4.39, 4.91, 10.60, 24.16, 122.29, 122.38, 123.8, 146.32... substantially holders or containers 1515-0116 § 10.41b(e) Requirement to keep adequate records on current status...

19 CFR 178.2 - Listing of OMB control numbers.

Code of Federal Regulations, 2012 CFR

2012-04-01

... inward manifests 1515-0142 § 4.7a(c)(4) Transportation manifest (cargo declaration) 1651-0001 §§ 4.7b, 4... Container status messages §§ 4.10, 4.16, 4.30, 4.37, 4.39, 4.91, 10.60, 24.16, 122.29, 122.38, 123.8, 146.32... substantially holders or containers 1515-0116 § 10.41b(e) Requirement to keep adequate records on current status...

19 CFR 178.2 - Listing of OMB control numbers.

Code of Federal Regulations, 2013 CFR

2013-04-01

... inward manifests 1515-0142 § 4.7a(c)(4) Transportation manifest (cargo declaration) 1651-0001 §§ 4.7b, 4... Container status messages §§ 4.10, 4.16, 4.30, 4.37, 4.39, 4.91, 10.60, 24.16, 122.29, 122.38, 123.8, 146.32... substantially holders or containers 1515-0116 § 10.41b(e) Requirement to keep adequate records on current status...

19 CFR 178.2 - Listing of OMB control numbers.

Code of Federal Regulations, 2011 CFR

2011-04-01

... inward manifests 1515-0142 § 4.7a(c)(4) Transportation manifest (cargo declaration) 1651-0001 §§ 4.7b, 4... Container status messages §§ 4.10, 4.16, 4.30, 4.37, 4.39, 4.91, 10.60, 24.16, 122.29, 122.38, 123.8, 146.32... substantially holders or containers 1515-0116 § 10.41b(e) Requirement to keep adequate records on current status...

Environmental Interactions Technology Status

DTIC Science & Technology

1986-10-01

4 1 - 3 - - 3 - High-Voltage Interactions 4 4 1 3 3 1 3 3 1 HIGH ENERGY RADIATION: - Radiation Damage to: - Electronics - 4 4 - 4 4 - 4 4 - Solar ...3), High Energy Radiation Environments (Section 4), Neutral Environments (Section 5), Particle Environments (Section 6), Solar Radiation Environments...secondary mirror, and light collector surrounding the small solar cell. No cover glass is required. Only recently has a study been undertaken to evaluate the

Department of the Navy Justification of Estimates for Fiscal Year 1988/1989 Submitted to Congress. Procurement. Other Procurement, Navy.

DTIC Science & Technology

1987-01-01

7 7ZD- AISI 9721 PffARTMENT OF THE NAVY JUffjA~j HFC S A FO L/L U I (NAUil) WASHINC ON C JAN&LNCLASS IFI ED F/G 5/1 NL I M2 I12 5 coo~ LIFJ -I LII...0 4 4)-s.. -4 4J C: 00 + ,. LI0a 4)00&.4. 00a 4)CA.V f0 4- > 1 - 1 404- 4JLA. 0- =. i.- >, 0h0 a0 cn 4 (40 s.4 > 4 24*~ (-A *.eZ---. 0. .. ., tv 4140

Validating Biomarkers for PTSD

DTIC Science & Technology

2015-04-01

Recall Participants by Site Recruitment Site Procedure Q1 Q2 Q3 Q4 Year 1 Total NYUMC BCI * 6 5 4 6 21 Blood draw 0 8 4 4 16 Self-report 0 7 4 4...15 Brain imaging 1 8 5 0 14 NCT** 0 7 4 4 15 JJPVAMC/MMSM BCI * 2 4 6 3 15 Blood draw 1 4 4 2 11 Self-report 2 2 5 1 10 Brain imaging 1 2 2 0 5...NCT** 0 4 5 1 10 * BCI = Baseline Clinical Interview **NCT = Neurocognitive Testing Table 3. Completed Procedures for Validating Biomarkers New

United States Air Force Statistical Digest, Fiscal Year 2000

DTIC Science & Technology

2000-09-30

international affairs; general science, space, and technology; agriculture; administration of justice ; general government; and undistributed offsetting receipts...0.6 0.6 0.9 0.6 0.6 A6 ENVIRONMENTAL RESTORATION-AF 0.0 0.4 0.4 0.4 0.4 NOTES: (1) Totals may not add due to rounding. (2) Amounts are as of the FY02... ALABAMA 7,067 7,407 7,085 7,063 6,993 6,795 6,586 6,478 Military 4,735 4,977 4,862 4,899 4,811 4,593 4,444 4,299 Civilian 2,332 2,430 2,223 2,164

Department of the Navy Justification of Estimates FY 1991 Budget Estimates Submitted to Congress January 1990, Operation & Maintenance, Navy. Book 1. Budget Activity 1. Strategic Forces. Budget Activity 2. General Purpose Forces. Budget Activity 3. Intelligence & Communications. Budget Activity 4. Airlift and Sealift.

DTIC Science & Technology

1990-01-01

W a jwý 0 c! l U) to 0 C: C3 tdl &-j 𔃺 10 0 r r -" .-4GJ -4 w 4-𔃼w w .- 4 W &a’’ 0 󈧰 0 >1V) ( td ’- ~u 0 4 b W -4 a)i 0 1l-4 a, .. n (I = 0 -4 ý...to0 d)r- $4. 0)0 r. cd .,-~~ 4 C:s o a) (n44E-𔃺C W 0. 44CLH td c~ - 0ý 0r a;i w-4’-4 0’r0.. 12O4’w.. X-.41m C0) en (d 3)b-%- u s~~ -40r n 0- 1 0 0...c- ~ Li * to wC~C 0’~ -4 L)CrO0-40 CLTý -4 14 CLU L> w)i VQ. V) Li)- td -III.- 0 U -4 W ed Q C U - H bOC E 0 w u -𔃾 r-4 w &J.- w 4 0-I kw -H = IV -4

Formation of 4-ethoxy-4'-nitrosodiphenylamine in the reaction of the phenacetin metabolite 4-nitrosophenetol with glutathione.

PubMed

Klehr, H; Eyer, P; Schäfer, W

1987-08-01

Phenacetin, a constituent of several analgesic and antipyretic formulations has been made responsible for a variety of toxic and carcinogenic actions. 4-Nitrosophenetol, the N-oxydation product of intermediate 4-phenetidine, forms methemoglobin and binds covalently to sulfhydryl groups of proteins and glutathione. In the reaction of 4-nitrosophenetol with glutathione and other thiols an intermediate so-called "semimercaptal" is formed from which N-(thiol-S-yl)-4-phenetidine S-oxide, N-(thiol-S-yl)-4-phenetidine and 4-phenetidine derive. Besides thiol adducts, a yellow compound is formed which was isolated as a pure crystalline product (elemental analysis) and identified by FAB-MS, EI-MS, 13C-, 1H-NMR, and UV-VIS spectroscopy as 4-ethoxy-4'-nitrosodiphenylamine. This nitrosoarene is formed by an unknown mechanism from 4-nitrosophenetol and 4-phenetidine under liberation of ethanol. In human erythrocytes this compound is easily reduced to 4-amino-4'-ethoxydiphenylamine (FAB-MS, EI-MS, 13C-NMR). During the reaction of 4-nitrosophenetol with red cells only traces of 4-ethoxy-4'-nitrosodiphenylamine were formed, whereas up to 10% appeared as the reduction product 4-amino-4'-ethoxydiphenylamine. This latter compound is unstable in red cells and is metabolized further to unidentified products.

Innovative insertion material of LiAl 1/4Ni 3/4O 2 ( R- m) for lithium-ion (shuttlecock) batteries

NASA Astrophysics Data System (ADS)

Ohzuku, Tsutomu; Yanagawa, Takayuki; Kouguchi, Masaru; Ueda, Atsushi

We report an innovative insertion material of LiAl 1/4Ni 3/4O 2 ( R- m) which is a solid solution of LiNiO 2 ( R— m) and α-LiAlO 2 ( R— m). LiAl 1/4Ni 3/4O 2 (interlayer distance: ~4.75 Å) shows an overcharge-resistant character due to the formation of an insulator of 3/4Li 1/4-Al 1/4Ni 3/4O 2 having ~ 4.8 Å of interlayer distance. Cycle tests of an Li/LiAl 1/4Ni 3/4O 2 cell between 2.5 and 4.5 V show no noticeable loss in rechargeable capacity (~ 150 mAh g -1). The thermal behavior of Li 1 - xAl 1/4Ni 3/4O 2 (0 ≤ x <3/4) is also examined by differential scanning calorimetry and shows that the exothermic reaction of Li 1 - xAl 1/4Ni 3/4O 2 with electrolyte is remarkably suppressed even for the fully charged state when compared with that of Li 1 - xNiO 2. From these results we discuss on the possibility of designing reliable high-energy, high-volume, lithium-ion batteries.

Thermoelectric properties of Co(x)Ni(4-x)Sb(12-y)Sn(y) ternary skutterudites

NASA Technical Reports Server (NTRS)

Mackey, Jon A.; Dynys, Frederick W.; Sehirlioglu, Alp

2014-01-01

Thermoelectric materials based on the skutterudite crystal structure have demonstrated enhanced performance (ZT greater than 1), along with good thermal stability and favorable mechanical properties. Binary skutterudites, with single and multiple fillers, have been intensively studied in recent years. Compared to binary skutterudites, the ternary systems have received less attention, e.g. Ni4Sb8Sn4. Ternary skutterudites are isoelectronic variants of binary skutterudites; cation substitutions appear to be isostructural to their binary analogues. In general, ternary skutterudites exhibit lower thermal conductivity. Ternary systems of Ni4Bi8Ge4, Ni4Sb8Ge4, and Ni4Sb8Sn4 were investigated using combined solidification and sintering steps. Skutterudite formation was not achieved in the Ni4Bi8Ge4 and Ni4Sb8Ge4 systems; skutterudite formation occurred in Ni4Sb8Sn4 system. P-type material was achieved by Co substitution for Ni. Thermoelectric properties were measured from 298 K to 673 K for Ni4Sb8Sn4, Ni4 Sb7Sn5 and Co2Ni2Sb7Sn5. N-type Ni4Sb8Sn4 exhibit the highest figure of merit of 0.1 at 523 K.

CERES ERBE-like Monthly Geographical Averages (ES-4) in HDF (CER_ES4_FM1+FM4_Edition2)

NASA Technical Reports Server (NTRS)

Wielicki, Bruce A. (Principal Investigator)

The ERBE-like Monthly Geographical Averages (ES-4) product contains a month of space and time averaged Clouds and the Earth's Radiant Energy System (CERES) data for a single scanner instrument. The ES-4 is also produced for combinations of scanner instruments. For each observed 2.5-degree spatial region, the daily average, the hourly average over the month, and the overall monthly average of shortwave and longwave fluxes at the Top-of-the-Atmosphere (TOA) from the CERES ES-9 product are spatially nested up from 2.5-degree regions to 5- and 10-degree regions, to 2.5-, 5-, and 10-degree zonal averages, and to global monthly averages. For each nested area, the albedo and net flux are given. For each region, the daily average flux is estimated from an algorithm that uses the available hourly data, scene identification data, and diurnal models. This algorithm is 'like' the algorithm used for the Earth Radiation Budget Experiment (ERBE). The following CERES ES4 data sets are currently available: CER_ES4_FM1+FM2_Edition1 CER_ES4_PFM+FM1+FM2_Edition1 CER_ES4_PFM+FM1+FM2_Edition2 CER_ES4_PFM+FM1_Edition1 CER_ES4_PFM+FM2_Edition1 CER_ES4_TRMM-PFM_Edition1 CER_ES4_TRMM-PFM_Edition2 CER_ES4_Terra-FM1_Edition1 CER_ES4_Terra-FM2_Edition1 CER_ES4_FM1+FM2_Edition2 CER_ES4_Terra-FM1_Edition2 CER_ES4_Terra-FM2_Edition2 CER_ES4_Aqua-FM3_Edition1 CER_ES4_Aqua-FM4_Edition1 CER_ES4_FM1+FM2+FM3+FM4_Edition1 CER_ES4_Aqua-FM3_Edition2 CER_ES4_Aqua-FM4_Edition2 CER_ES4_FM1+FM3_Edition2 CER_ES4_FM1+FM4_Edition2 CER_ES4_PFM+FM1_Edition2 CER_ES4_PFM+FM2_Edition2 CER_ES4_Aqua-FM3_Edition1-CV CER_ES4_Aqua-FM4_Edition1-CV CER_ES4_Terra-FM1_Edition1-CV CER_ES4_Terra-FM2_Edition1-CV. [Location=GLOBAL] [Temporal_Coverage: Start_Date=1998-01-01; Stop_Date=2005-03-31] [Spatial_Coverage: Southernmost_Latitude=-90; Northernmost_Latitude=90; Westernmost_Longitude=-180; Easternmost_Longitude=180] [Data_Resolution: Latitude_Resolution=2.5 degree; Longitude_Resolution=2.5 degree; Horizontal_Resolution_Range=250 km - < 500 km or approximately 2.5 degrees - < 5.0 degrees; Temporal_Resolution=1 month; Temporal_Resolution_Range=Monthly - < Annual].

CERES ERBE-like Monthly Geographical Averages (ES-4) in HDF (CER_ES4_Aqua-FM4_Edition1)

NASA Technical Reports Server (NTRS)

Wielicki, Bruce A. (Principal Investigator)

The ERBE-like Monthly Geographical Averages (ES-4) product contains a month of space and time averaged Clouds and the Earth's Radiant Energy System (CERES) data for a single scanner instrument. The ES-4 is also produced for combinations of scanner instruments. For each observed 2.5-degree spatial region, the daily average, the hourly average over the month, and the overall monthly average of shortwave and longwave fluxes at the Top-of-the-Atmosphere (TOA) from the CERES ES-9 product are spatially nested up from 2.5-degree regions to 5- and 10-degree regions, to 2.5-, 5-, and 10-degree zonal averages, and to global monthly averages. For each nested area, the albedo and net flux are given. For each region, the daily average flux is estimated from an algorithm that uses the available hourly data, scene identification data, and diurnal models. This algorithm is 'like' the algorithm used for the Earth Radiation Budget Experiment (ERBE). The following CERES ES4 data sets are currently available: CER_ES4_FM1+FM2_Edition1 CER_ES4_PFM+FM1+FM2_Edition1 CER_ES4_PFM+FM1+FM2_Edition2 CER_ES4_PFM+FM1_Edition1 CER_ES4_PFM+FM2_Edition1 CER_ES4_TRMM-PFM_Edition1 CER_ES4_TRMM-PFM_Edition2 CER_ES4_Terra-FM1_Edition1 CER_ES4_Terra-FM2_Edition1 CER_ES4_FM1+FM2_Edition2 CER_ES4_Terra-FM1_Edition2 CER_ES4_Terra-FM2_Edition2 CER_ES4_Aqua-FM3_Edition1 CER_ES4_Aqua-FM4_Edition1 CER_ES4_FM1+FM2+FM3+FM4_Edition1 CER_ES4_Aqua-FM3_Edition2 CER_ES4_Aqua-FM4_Edition2 CER_ES4_FM1+FM3_Edition2 CER_ES4_FM1+FM4_Edition2 CER_ES4_PFM+FM1_Edition2 CER_ES4_PFM+FM2_Edition2 CER_ES4_Aqua-FM3_Edition1-CV CER_ES4_Aqua-FM4_Edition1-CV CER_ES4_Terra-FM1_Edition1-CV CER_ES4_Terra-FM2_Edition1-CV. [Location=GLOBAL] [Temporal_Coverage: Start_Date=1998-01-01; Stop_Date=2005-03-29] [Spatial_Coverage: Southernmost_Latitude=-90; Northernmost_Latitude=90; Westernmost_Longitude=-180; Easternmost_Longitude=180] [Data_Resolution: Latitude_Resolution=2.5 degree; Longitude_Resolution=2.5 degree; Horizontal_Resolution_Range=250 km - < 500 km or approximately 2.5 degrees - < 5.0 degrees; Temporal_Resolution=1 month; Temporal_Resolution_Range=Monthly - < Annual].

CERES ERBE-like Monthly Geographical Averages (ES-4) in HDF (CER_ES4_Aqua-FM4_Edition2)

NASA Technical Reports Server (NTRS)

Wielicki, Bruce A. (Principal Investigator)

The ERBE-like Monthly Geographical Averages (ES-4) product contains a month of space and time averaged Clouds and the Earth's Radiant Energy System (CERES) data for a single scanner instrument. The ES-4 is also produced for combinations of scanner instruments. For each observed 2.5-degree spatial region, the daily average, the hourly average over the month, and the overall monthly average of shortwave and longwave fluxes at the Top-of-the-Atmosphere (TOA) from the CERES ES-9 product are spatially nested up from 2.5-degree regions to 5- and 10-degree regions, to 2.5-, 5-, and 10-degree zonal averages, and to global monthly averages. For each nested area, the albedo and net flux are given. For each region, the daily average flux is estimated from an algorithm that uses the available hourly data, scene identification data, and diurnal models. This algorithm is 'like' the algorithm used for the Earth Radiation Budget Experiment (ERBE). The following CERES ES4 data sets are currently available: CER_ES4_FM1+FM2_Edition1 CER_ES4_PFM+FM1+FM2_Edition1 CER_ES4_PFM+FM1+FM2_Edition2 CER_ES4_PFM+FM1_Edition1 CER_ES4_PFM+FM2_Edition1 CER_ES4_TRMM-PFM_Edition1 CER_ES4_TRMM-PFM_Edition2 CER_ES4_Terra-FM1_Edition1 CER_ES4_Terra-FM2_Edition1 CER_ES4_FM1+FM2_Edition2 CER_ES4_Terra-FM1_Edition2 CER_ES4_Terra-FM2_Edition2 CER_ES4_Aqua-FM3_Edition1 CER_ES4_Aqua-FM4_Edition1 CER_ES4_FM1+FM2+FM3+FM4_Edition1 CER_ES4_Aqua-FM3_Edition2 CER_ES4_Aqua-FM4_Edition2 CER_ES4_FM1+FM3_Edition2 CER_ES4_FM1+FM4_Edition2 CER_ES4_PFM+FM1_Edition2 CER_ES4_PFM+FM2_Edition2 CER_ES4_Aqua-FM3_Edition1-CV CER_ES4_Aqua-FM4_Edition1-CV CER_ES4_Terra-FM1_Edition1-CV CER_ES4_Terra-FM2_Edition1-CV. [Location=GLOBAL] [Temporal_Coverage: Start_Date=1998-01-01; Stop_Date=2005-03-29] [Spatial_Coverage: Southernmost_Latitude=-90; Northernmost_Latitude=90; Westernmost_Longitude=-180; Easternmost_Longitude=180] [Data_Resolution: Latitude_Resolution=2.5 degree; Longitude_Resolution=2.5 degree; Horizontal_Resolution_Range=250 km - < 500 km or approximately 2.5 degrees - < 5.0 degrees; Temporal_Resolution=1 month; Temporal_Resolution_Range=Monthly - < Annual].

CERES ERBE-like Monthly Geographical Averages (ES-4) in HDF (CER_ES4_Aqua-FM4_Edition1-CV)

NASA Technical Reports Server (NTRS)

Wielicki, Bruce A. (Principal Investigator)

The ERBE-like Monthly Geographical Averages (ES-4) product contains a month of space and time averaged Clouds and the Earth's Radiant Energy System (CERES) data for a single scanner instrument. The ES-4 is also produced for combinations of scanner instruments. For each observed 2.5-degree spatial region, the daily average, the hourly average over the month, and the overall monthly average of shortwave and longwave fluxes at the Top-of-the-Atmosphere (TOA) from the CERES ES-9 product are spatially nested up from 2.5-degree regions to 5- and 10-degree regions, to 2.5-, 5-, and 10-degree zonal averages, and to global monthly averages. For each nested area, the albedo and net flux are given. For each region, the daily average flux is estimated from an algorithm that uses the available hourly data, scene identification data, and diurnal models. This algorithm is 'like' the algorithm used for the Earth Radiation Budget Experiment (ERBE). The following CERES ES4 data sets are currently available: CER_ES4_FM1+FM2_Edition1 CER_ES4_PFM+FM1+FM2_Edition1 CER_ES4_PFM+FM1+FM2_Edition2 CER_ES4_PFM+FM1_Edition1 CER_ES4_PFM+FM2_Edition1 CER_ES4_TRMM-PFM_Edition1 CER_ES4_TRMM-PFM_Edition2 CER_ES4_Terra-FM1_Edition1 CER_ES4_Terra-FM2_Edition1 CER_ES4_FM1+FM2_Edition2 CER_ES4_Terra-FM1_Edition2 CER_ES4_Terra-FM2_Edition2 CER_ES4_Aqua-FM3_Edition1 CER_ES4_Aqua-FM4_Edition1 CER_ES4_FM1+FM2+FM3+FM4_Edition1 CER_ES4_Aqua-FM3_Edition2 CER_ES4_Aqua-FM4_Edition2 CER_ES4_FM1+FM3_Edition2 CER_ES4_FM1+FM4_Edition2 CER_ES4_PFM+FM1_Edition2 CER_ES4_PFM+FM2_Edition2 CER_ES4_Aqua-FM3_Edition1-CV CER_ES4_Aqua-FM4_Edition1-CV CER_ES4_Terra-FM1_Edition1-CV CER_ES4_Terra-FM2_Edition1-CV. [Location=GLOBAL] [Temporal_Coverage: Start_Date=1998-01-01; Stop_Date=2005-03-29] [Spatial_Coverage: Southernmost_Latitude=-90; Northernmost_Latitude=90; Westernmost_Longitude=-180; Easternmost_Longitude=180] [Data_Resolution: Latitude_Resolution=2.5 degree; Longitude_Resolution=2.5 degree; Horizontal_Resolution_Range=250 km - < 500 km or approximately 2.5 degrees - < 5.0 degrees; Temporal_Resolution=1 month; Temporal_Resolution_Range=Monthly - < Annual].

The cohering telomeres of Oxytricha.

PubMed Central

Oka, Y; Thomas, C A

1987-01-01

We have studied the process by which purified Oxytricha macronuclear DNA associates with itself to form large aggregates. The various macronuclear DNA molecules all have the same terminal or telomeric DNA sequences that are shown below. 5' C4A4C4A4C4--mean length----G4T4G4T4G4T4G4T4G4 G4T4G4T4G4T4G4T4G4-----2.4 kb------C4A4C4A4C4. When incubated at high concentrations, these telomeric sequences cohere with one another to form an unusual structure--one that is quite different from any DNA structure so far described. The evidence for this is the following: 1) These sequences cohere albeit slowly, in the presence of relatively high concentrations of Na+, and no other cation tested. This contrasts with the rapid coherence of complementary single-chain terminals of normal DNA (sticky ends) which occurs in the presence of any cation tested. 2) If the cohered form is transferred into buffers containing a special cation, K+, it becomes much more resistant to dissociation by heating. We estimate that K+ increases the thermal stability by 25 degrees or more. The only precedent known (to us) for a cation-specific stabilization is that seen in the quadruplex structure formed by poly I. The thermal stability of double helical macronuclear DNA depends on the cation concentration, but not the cation type. Limited treatment with specific nucleases show that the 3' and 5'-ended strands are essential for the formation of the cohering structure. Once in the cohered form, the telomeric sequences are protected from the action of nucleases. Coherence is inhibited by specific, but not by non-specific, synthetic oligomers, and by short telomeric fragments with or without their terminal single chains. We conclude that the coherence occurs by the formation of a novel condensed structure that involves the terminal nucleotides in three or four chains. Images PMID:3120149

Control of eIF4E cellular localization by eIF4E-binding proteins, 4E-BPs.

PubMed

Rong, Liwei; Livingstone, Mark; Sukarieh, Rami; Petroulakis, Emmanuel; Gingras, Anne-Claude; Crosby, Katherine; Smith, Bradley; Polakiewicz, Roberto D; Pelletier, Jerry; Ferraiuolo, Maria A; Sonenberg, Nahum

2008-07-01

Eukaryotic initiation factor (eIF) 4E, the mRNA 5'-cap-binding protein, mediates the association of eIF4F with the mRNA 5'-cap structure to stimulate cap-dependent translation initiation in the cytoplasm. The assembly of eIF4E into the eIF4F complex is negatively regulated through a family of repressor proteins, called the eIF4E-binding proteins (4E-BPs). eIF4E is also present in the nucleus, where it is thought to stimulate nuclear-cytoplasmic transport of certain mRNAs. eIF4E is transported to the nucleus via its interaction with 4E-T (4E-transporter), but it is unclear how it is retained in the nucleus. Here we show that a sizable fraction (approximately 30%) of 4E-BP1 is localized to the nucleus, where it binds eIF4E. In mouse embryo fibroblasts (MEFs) subjected to serum starvation and/or rapamycin treatment, nuclear 4E-BPs sequester eIF4E in the nucleus. A dramatic loss of nuclear 4E-BP1 occurs in c-Ha-Ras-expressing MEFs, which fail to show starvation-induced nuclear accumulation of eIF4E. Therefore, 4E-BP1 is a regulator of eIF4E cellular localization.

Control of eIF4E cellular localization by eIF4E-binding proteins, 4E-BPs

PubMed Central

Rong, Liwei; Livingstone, Mark; Sukarieh, Rami; Petroulakis, Emmanuel; Gingras, Anne-Claude; Crosby, Katherine; Smith, Bradley; Polakiewicz, Roberto D.; Pelletier, Jerry; Ferraiuolo, Maria A.; Sonenberg, Nahum

2008-01-01

Eukaryotic initiation factor (eIF) 4E, the mRNA 5′-cap-binding protein, mediates the association of eIF4F with the mRNA 5′-cap structure to stimulate cap-dependent translation initiation in the cytoplasm. The assembly of eIF4E into the eIF4F complex is negatively regulated through a family of repressor proteins, called the eIF4E-binding proteins (4E-BPs). eIF4E is also present in the nucleus, where it is thought to stimulate nuclear-cytoplasmic transport of certain mRNAs. eIF4E is transported to the nucleus via its interaction with 4E-T (4E-transporter), but it is unclear how it is retained in the nucleus. Here we show that a sizable fraction (∼30%) of 4E-BP1 is localized to the nucleus, where it binds eIF4E. In mouse embryo fibroblasts (MEFs) subjected to serum starvation and/or rapamycin treatment, nuclear 4E-BPs sequester eIF4E in the nucleus. A dramatic loss of nuclear 4E-BP1 occurs in c-Ha-Ras–expressing MEFs, which fail to show starvation-induced nuclear accumulation of eIF4E. Therefore, 4E-BP1 is a regulator of eIF4E cellular localization. PMID:18515545

HEC-4 Monthly Streamflow Simulation (User’s Manual)

DTIC Science & Technology

1971-02-01

adding this product to the uroduct of the complement of this multiplier and the value of the ele - ment in the inconsistent matrix. The averaged or...the month pre- ceding the first month specified (by input data) to be generated. The var-’ ele M.1A is comnutel f’or the subscript o" ; that conforms...1-4 .f’o .Td74 r m 1i4 tf’t 0atQ P PkPkk4 el %04 k04 fl 0 -41. ----- 4-4-4 a-4 -44 44-4- - -4 *fF_4Q cacao---1 00 0404- -4 Cb 0 0-r-o .0. 4

Anthropometric Source Book. Volume 2: A Handbook of Anthropometric Data

DTIC Science & Technology

1978-07-01

a.mw* % A W " " -I4 0-4DB~M’a~P Z.=22014 MO ZW=O𔃾WW4L" 0 "OBCOO&WWOWWBAB z z 34 " 14 0-44 BBP o z:.~Bwz 1 Wz0 V1O󈧵 j =P.’)ON- 01-0 e e o 0 t...4 c: P) POP~f pol IV)~) ~ P)V) t) PFrW)WW))m x dCY4 0- -a I.- - 0 ~ ItTt t: 1 1 % t’Q.4 O’*t%if! N D Dc ! 4 1Dff~ ffa ul In .4 NV4 W v4 q4v4 v4 NUM

Single Crystal Epitaxy and Characterization of Beta-SiC.

DTIC Science & Technology

1982-07-01

and CH4 (35, 40), SiC] 4 and C3H8 (40-43), SiCl4 and C6H6 (37), SiCl4 and C7H8 (37, 44), and SiC]4 and CCI 4 (45-47). In all cases, the carrier gas...crystal layer on top of the as-formed 8-SiC substrate. Their problem may arise from the use of the gas combination of SiCl4 and CCI 4, because still...falling between those for the CH4- and the C2H4-c-ritaining systems. (4) The SiCl4 /CCI4/H2 System The species considered to be in the gaseous phase of

Prebiotic synthesis of imidazole-4-acetaldehyde and histidine

NASA Astrophysics Data System (ADS)

Shen, Chun; Yang, Lily; Miller, Stanley L.; Oró, J.

1987-09-01

The prebiotic synthesis of imidazole-4-acetaldehyde and imidazole-4-glycol from erythrose and formamidine has been demonstrated as well as the prebiotic synthesis of imidazole-4-ethanol and imidazole-4-glycol from erythrose, formaldehyde and ammonia. The products were identified by TLC, HPLC, and LC-MS by comparison with authentic samples. The maximum yields of imidazole-4-acetaldehyde, imidazole-4-ethanol, and imidazole-4-glycol obtained in these reactions are 1.6, 5.4, 6.8% respectively, based on the erythrose. Imidazole-4-acetaldehyde would have been converted to histidine on the primitive earth by a Strecker synthesis, and several prebiotic reactions would convert imidazole-4-glycol and imidazole-4-ethanol to imidazole-4-acetaldehyde.

Competing Pathways in the photo- Proton-Coupled Electron Transfer Reduction of fac -[Re(bpy)(CO) 3 (4,4'-bpy] +* by Hydroquinone

DOE Office of Scientific and Technical Information (OSTI.GOV)

Stewart, David J.; Brennaman, M. Kyle; Bettis, Stephanie E.

2011-08-04

The emitting metal-to-ligand charge transfer (MLCT) excited state of fac-[Re{sup I}(bpy)(CO)₃(4,4'-bpy)] + (1) (bpy is 2,2'-bipyridine, 4,4'-bpy is 4,4'-bipyridine), [Re II(bpy –•)(CO)₃(4,4'-bpy)] +*, is reductively quenched by 1,4-hydroquinone (H₂Q) in CH₃CN at 23 ± 2 °C by competing pathways to give a common electron–proton-transfer intermediate. In one pathway, electron transfer (ET) quenching occurs to give Re{sup I}(bpy –•)(CO)₃(4,4'-bpy)]⁰ with k = (1.8 ± 0.2) × 10⁹ M –1 s –1, followed by proton transfer from H₂Q to give [Re I(bpy)(CO)₃(4,4'-bpyH •)] +. Protonation triggers intramolecular bpy –•→ 4,4'-bpyH{sup +} electron transfer. In the second pathway, preassociationmore » occurs between the ground state and H₂Q at high concentrations. Subsequent Re → bpy MLCT excitation of the adduct is followed by electron–proton transfer from H₂Q in concert with intramolecular bpy –•→ 4,4'-bpyH + electron transfer to give [Re I(bpy)(CO)₃(4,4'-bpyH •)] + with k = (1.0 ± 0.4) × 10⁹ s –1 in 3:1 CH₃CN/H₂O.« less

Synthesis, structures and properties of the new lithium cobalt(II) phosphate Li{sub 4}Co(PO{sub 4}){sub 2}

DOE Office of Scientific and Technical Information (OSTI.GOV)

Glaum, R., E-mail: rglaum@uni-bonn.de; Gerber, K.; Schulz-Dobrick, M.

2012-04-15

{alpha}-Li{sub 4}Co(PO{sub 4}){sub 2} has been synthesized and crystallized by solid-state reactions. The new phosphate crystallizes in the monoclinic system (P2{sub 1}/a, Z=4, a=8.117(3) Angstrom-Sign , b=10.303(8) Angstrom-Sign , c=8.118(8) Angstrom-Sign , {beta}=104.36(8) Angstrom-Sign ) and is isotypic to {alpha}-Li{sub 4}Zn(PO{sub 4}){sub 2}. The structure of {alpha}-Li{sub 4}Co(PO{sub 4}){sub 2} has been determined from single-crystal X-ray diffraction data {l_brace}R{sub 1}=0.040, wR{sub 2}=0.135, 2278 unique reflections with F{sub o}>4{sigma}(F{sub o}){r_brace}. The crystal structure, which might be regarded as a superstructure of the wurtzite structure type, is build of layers of regular CoO{sub 4}, PO{sub 4} and Li1O{sub 4} tetrahedra. Lithium atomsmore » Li2, Li3 and Li4 are located between these layers. Thermal investigations by in-situ XRPD, DTA/TG and quenching experiments suggest decomposition followed by formation and phase transformation of Li{sub 4}Co(PO{sub 4}){sub 2}: {alpha}-Li{sub 4}Co(PO{sub 4}){sub 2} Long-Rightwards-Double-Arrow {sup 442 Degree-Sign C}{beta}-Li{sub 3}PO{sub 4}+LiCoPO{sub 4} Rightwards-Harpoon-Over-Leftwards-Harpoon {sup 773 Degree-Sign C}{beta}-Li{sub 4}Co(PO{sub 4}){sub 2} Long-Rightwards-Double-Arrow {sup quenchingto25 Degree-Sign C}{alpha}-Li{sub 4} Co(PO{sub 4}){sub 2} According to HT-XRPD at {theta}=850 Degree-Sign C{beta}-Li{sub 4}Co(PO{sub 4}){sub 2} (Pnma, Z=2, 10.3341(8) A, b=6.5829(5) A, c=5.0428(3) Angstrom-Sign ) is isostructural to {gamma}-Li{sub 3}PO{sub 4}. The powder reflectance spectrum of {alpha}-Li{sub 4}Co(PO{sub 4}){sub 2} shows the typical absorption bands for the tetrahedral chromophore [Co{sup II}O{sub 4}]. - Graphical abstract: The complex formation and decomposition behavior of Li{sub 4}Co(PO{sub 4}){sub 2} with temperature has been elucidated. The crystal structure of its {alpha}-phase was determined from single crystal data, HT-XRPD allowed derivation of a structure model for the {beta}-phase. Both modifications belong to the Li{sub 3}PO{sub 4} structure family. Highlights: Black-Right-Pointing-Pointer Li{sub 4}Co(PO{sub 4}){sub 2} exhibits complex thermal behavior. Black-Right-Pointing-Pointer The new phosphate belongs to the Li{sub 3}PO{sub 4} structure family. Black-Right-Pointing-Pointer A single-crystal structure analysis is provided for the metastable {alpha}-Li{sub 4}Co(PO{sub 4}){sub 2}. Black-Right-Pointing-Pointer From HT-XRPD data a cation distribution model is developed for {beta}-Li{sub 4}Co(PO{sub 4}){sub 2}. Black-Right-Pointing-Pointer No electrochemical delithiation is observed up to 5 V.« less

10 CFR 960.4-2-4 - Climatic changes.

Code of Federal Regulations, 2014 CFR

2014-01-01

... 10 Energy 4 2014-01-01 2014-01-01 false Climatic changes. 960.4-2-4 Section 960.4-2-4 Energy... REPOSITORY Postclosure Guidelines § 960.4-2-4 Climatic changes. (a) Qualifying condition. The site shall be...) Favorable conditions. (1) A surface-water system such that expected climatic cycles over the next 100,000...

10 CFR 960.4-2-4 - Climatic changes.

Code of Federal Regulations, 2011 CFR

2011-01-01

... 10 Energy 4 2011-01-01 2011-01-01 false Climatic changes. 960.4-2-4 Section 960.4-2-4 Energy... REPOSITORY Postclosure Guidelines § 960.4-2-4 Climatic changes. (a) Qualifying condition. The site shall be...) Favorable conditions. (1) A surface-water system such that expected climatic cycles over the next 100,000...

Improving Real World Performance of Vision Aided Navigation in a Flight Environment

DTIC Science & Technology

2016-09-15

Introduction . . . . . . . 63 4.2 Wide Area Search Extent . . . . . . . . . . . . . . . . . 64 4.3 Large-Scale Image Navigation Histogram Filter ...65 4.3.1 Location Model . . . . . . . . . . . . . . . . . . 66 4.3.2 Measurement Model . . . . . . . . . . . . . . . 66 4.3.3 Histogram Filter ...Iteration of Histogram Filter . . . . . . . . . . . 70 4.4 Implementation and Flight Test Campaign . . . . . . . . 71 4.4.1 Software Implementation

40 CFR 180.379 - Fenvalerate; tolerances for residues.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 4/2/10 Almond, hulls 15.0 4/2/10 Apple 2.0 4/2/10 Artichoke, globe 0.2 4/2/10 Bean, dry, seed 0.25 4/2/10 Bean, snap, succulent 2.0 4/2/10 Broccoli 2.0 4/2/10 Blueberry 3.0 4/2/10 Cabbage 10.0 4/2/10...

40 CFR 180.331 - 4-(2,4-Dichlorophenoxy) butyric acid; tolerances for residues.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 40 Protection of Environment 23 2010-07-01 2010-07-01 false 4-(2,4-Dichlorophenoxy) butyric acid... Tolerances § 180.331 4-(2,4-Dichlorophenoxy) butyric acid; tolerances for residues. (a) General. Tolerances are established for residues of the herbicide 4-(2,4-dichlorophenoxy) butyric acid (2,4-DB), both free...

40 CFR 180.331 - 4-(2,4-Dichlorophenoxy) butyric acid; tolerances for residues.

Code of Federal Regulations, 2013 CFR

2013-07-01

... 40 Protection of Environment 25 2013-07-01 2013-07-01 false 4-(2,4-Dichlorophenoxy) butyric acid... Tolerances § 180.331 4-(2,4-Dichlorophenoxy) butyric acid; tolerances for residues. (a) General. Tolerances are established for residues of the herbicide 4-(2,4-dichlorophenoxy) butyric acid (2,4-DB), both free...

40 CFR 180.331 - 4-(2,4-Dichlorophenoxy) butyric acid; tolerances for residues.

Code of Federal Regulations, 2011 CFR

2011-07-01

... 40 Protection of Environment 24 2011-07-01 2011-07-01 false 4-(2,4-Dichlorophenoxy) butyric acid... Tolerances § 180.331 4-(2,4-Dichlorophenoxy) butyric acid; tolerances for residues. (a) General. Tolerances are established for residues of the herbicide 4-(2,4-dichlorophenoxy) butyric acid (2,4-DB), both free...

40 CFR 180.331 - 4-(2,4-Dichlorophenoxy) butyric acid; tolerances for residues.

Code of Federal Regulations, 2014 CFR

2014-07-01

... 40 Protection of Environment 24 2014-07-01 2014-07-01 false 4-(2,4-Dichlorophenoxy) butyric acid... Tolerances § 180.331 4-(2,4-Dichlorophenoxy) butyric acid; tolerances for residues. (a) General. Tolerances are established for residues of the herbicide 4-(2,4-dichlorophenoxy) butyric acid (2,4-DB), both free...

40 CFR 180.331 - 4-(2,4-Dichlorophenoxy) butyric acid; tolerances for residues.

Code of Federal Regulations, 2012 CFR

2012-07-01

... 40 Protection of Environment 25 2012-07-01 2012-07-01 false 4-(2,4-Dichlorophenoxy) butyric acid... Tolerances § 180.331 4-(2,4-Dichlorophenoxy) butyric acid; tolerances for residues. (a) General. Tolerances are established for residues of the herbicide 4-(2,4-dichlorophenoxy) butyric acid (2,4-DB), both free...

Telemetry Standards, RCC Standard 106-17, Chapter 4, Pulse Code Modulation Standards

DTIC Science & Technology

2017-07-01

Frame Structure .............................................................................................. 4-6 4.3.3 Cyclic Redundancy Check (Class...Spectral and BEP Comparisons for NRZ and Bi-phase............................................ A-3 A.4. PCM Frame Structure Examples...4-4 Figure 4-3. PCM Frame Structure .......................................................................................... 4-6

48 CFR 4.804-4 - Physically completed contracts.

Code of Federal Regulations, 2012 CFR

2012-10-01

... 48 Federal Acquisition Regulations System 1 2012-10-01 2012-10-01 false Physically completed contracts. 4.804-4 Section 4.804-4 Federal Acquisition Regulations System FEDERAL ACQUISITION REGULATION GENERAL ADMINISTRATIVE MATTERS Government Contract Files 4.804-4 Physically completed contracts. (a...

48 CFR 4.804-4 - Physically completed contracts.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 48 Federal Acquisition Regulations System 1 2010-10-01 2010-10-01 false Physically completed contracts. 4.804-4 Section 4.804-4 Federal Acquisition Regulations System FEDERAL ACQUISITION REGULATION GENERAL ADMINISTRATIVE MATTERS Government Contract Files 4.804-4 Physically completed contracts. (a...

48 CFR 4.804-4 - Physically completed contracts.

Code of Federal Regulations, 2013 CFR

2013-10-01

... 48 Federal Acquisition Regulations System 1 2013-10-01 2013-10-01 false Physically completed contracts. 4.804-4 Section 4.804-4 Federal Acquisition Regulations System FEDERAL ACQUISITION REGULATION GENERAL ADMINISTRATIVE MATTERS Government Contract Files 4.804-4 Physically completed contracts. (a...

48 CFR 4.804-4 - Physically completed contracts.

Code of Federal Regulations, 2011 CFR

2011-10-01

... 48 Federal Acquisition Regulations System 1 2011-10-01 2011-10-01 false Physically completed contracts. 4.804-4 Section 4.804-4 Federal Acquisition Regulations System FEDERAL ACQUISITION REGULATION GENERAL ADMINISTRATIVE MATTERS Government Contract Files 4.804-4 Physically completed contracts. (a...

48 CFR 4.804-4 - Physically completed contracts.

Code of Federal Regulations, 2014 CFR

2014-10-01

... 48 Federal Acquisition Regulations System 1 2014-10-01 2014-10-01 false Physically completed contracts. 4.804-4 Section 4.804-4 Federal Acquisition Regulations System FEDERAL ACQUISITION REGULATION GENERAL ADMINISTRATIVE MATTERS Government Contract Files 4.804-4 Physically completed contracts. (a...

Lubricant Performance and Evaluation.

DTIC Science & Technology

1987-06-01

Robert E. Kauffman * University of Day..on Research InstituteI Dayton, Ohio 4546; Jun 1987 S U- 4BD Interim Technical Report For Period17 June 1985...InI 133 43-.-l 311 u0.C ) 4- ta 0 0)0 m~tO tD r-ww D Chm4- -4 CD ") I-MW--- L)Ci 00 LnCD 0000004.4.(AJC cctO 0~ CO 4 LAU, CL 4) 4i M0 m 0 cmi CA...L)E- CP L) C,1-4 P)1- lz 1 0 "’ dccE-4 C") LA tD wx I (𔃻 :D W wI 363 0 -4 0) %0 0** *A ONV 9) kn k )4) 12LnA 4-4 0 0m - O .Dt-C%0 ~ 0 -0 *-LA .h %D

Geographic List of Prime Contract Awards. Oct 1992-Sep 1993. FY 1993. (Alpine, Utah-Pulaski, Virginia). Part 12

DTIC Science & Technology

1994-03-01

0in0 Aco00) o Y 1)-0 ONmN(0iOn 00 001Y)0 00C 00c 00 cca00 C. 11 0 IC (0 V 4JM-% II C4O(4 M00 0 MMN,-4.V-4 -- JCM 4JNCQ + 4-(n 4j tv1 +) (47 +3(4M + 347 ...0.440 0 0 0 0 N I mo wN 0 L) x- 4 lON I WOW 0... 4- u - U l ON I coI- 0I 0 Ný NOWO a .j 0 cc 0 4K lOO mo 4i I-- U. I-- 511 0oot- I. 4 1- I6- Ci I floON N

Department of the Navy Justification of Estimates for Fiscal Year 1988/ 1989 Submitted to Congress. Operation and Maintenance, Navy Reserve

DTIC Science & Technology

1987-01-01

t" td =U E 4-1 C-’M4- *+2 mU C 01 - 0 00 C01C ) fa .0 a) %A 4- 10 L- tor miE LA 01 Er~uO- 04-0 E . 0 CD u ft~o c ma-C uam 0 Ul (A &Ai %.o w1 0 C4-A M...06U S4D’’W 0 4-A 41 C % C 0 a, - ) .- 4. %A -- & - -v, ’ 4-0 C IVAU E 4-’ 4) ’q CL Q>C 4..C 0 "ow - 34A c IutoC 05 >’ m’U c = c 4) 4) 4. 3UV -t CL>%u ’ t

Geolocation Via Satellite: A Methodology and Error Analysis

DTIC Science & Technology

1988-05-01

o - sing cow0o sinoo (4.449) acoso = in a... ! (4.44b) asin1 _ acos = 0 (4.45) ax0 No0 2!!LO- = -cso sinI sinvo (4.46a) 89coso = io5s (4.46b) avo...CS6 av0 asinO = o (4.47a) acoso snocs (4.47b) asina = siflA acoso (4.48a) a9cosA - i + COS sin - sinqS0 asino aoo O-So COSOO c s sb aoo -COSA a9coso...4.48b) asinb __ cosa= 0 (4.49) ax0 ax0 asinA =_ sifl cosv - sinA acoso (4.50a) av0 cos OS v aCoSA CSflOO OS fl4o COSA ao ~ (4.50b) (9os acs a 0 * o4

Stabilization of Reduced Molybdenum-Iron-Sulfur Single and Double Cubane Clusters by Cyanide Ligation

PubMed Central

Pesavento, Russell P.; Berlinguette, Curtis P.; Holm, R. H.

2008-01-01

Recent work has shown that cyanide ligation increases the redox potentials of Fe4S4 clusters, enabling the isolation of [Fe4S4(CN)4]4−, the first synthetic Fe4S4 cluster obtained in the all-ferrous oxidation state (Scott, T. A.; Berlinguette, C. P.; Holm, R. H.; Zhou, H.-C., Proc. Natl. Acad. Sci. USA 2005, 102, 9741). The generality of reduced cluster stabilization has been examined with MoFe3S4 clusters. Reaction of single cubane [(Tp)MoFe3S4(PEt3)3]1+ and edge-bridged double cubane [(Tp)2Mo2Fe6S8(PEt3)4] with cyanide in acetonitrile affords [(Tp)MoFe3S4(CN)3]2− (2) and [(Tp)2Mo2Fe6S8(CN)4]4− (5), respectively. Reduction of 2 with KC14H10 yields [(Tp)MoFe3S4(CN)3]3− (3). Clusters were isolated in ca. 70–90% yields as Et4N+ or Bu4N+ salts; Clusters 3 and 5 contain all-ferrous cores; 3 is the first [MoFe3S4]1+ cluster isolated in substance. The structures of 2 and 3 are very similar; the volume of the reduced cluster core is slightly larger (2.5%), a usual effect upon reduction of cubane-type Fe4S4 and MFe3S4 clusters. Redox potentials and 57Fe isomer shifts of [(Tp)MoFe3S4L3]2−,3 and [(Tp)2Mo2Fe6S8L4]4−,3− clusters with L = CN, PhS, halide, and PEt3 are compared. Clusters with π-donor ligands (L = halide, PhS) exhibit larger isomer shifts and lower (more negative) redox potentials while π-acceptor ligands (L = CN, PEt3) induce smaller isomer shifts and higher (less negative) redox potentials. When potentials of 3/2 and [(Tp)MoFe3S4(SPh)3]3−/2− are compared, cyanide stabilizes 3 by 270 mV vs. the reduced thiolate cluster, commensurate with the 310 mV stabilization of [Fe4S4(CN)4]4− vs. [Fe4S4(SPh)4]4− where four ligands differ. These results demonstrate the efficacy of cyanide stabilization of lower cluster oxidation states. (Tp = hydrotris(pyrazolyl)borate(1−)). PMID:17279830

Stabilization of reduced molybdenum-iron-sulfur single- and double-cubane clusters by cyanide ligation.

PubMed

Pesavento, Russell P; Berlinguette, Curtis P; Holm, R H

2007-01-22

Recent work has shown that cyanide ligation increases the redox potentials of Fe(4)S(4) clusters, enabling the isolation of [Fe(4)S(4)(CN)4]4-, the first synthetic Fe(4)S(4) cluster obtained in the all-ferrous oxidation state (Scott, T. A.; Berlinguette, C. P.; Holm, R. H.; Zhou, H.-C. Proc. Natl. Acad. Sci. U.S.A. 2005, 102, 9741). The generality of reduced cluster stabilization has been examined with MoFe(3)S(4) clusters. Reaction of single-cubane [(Tp)MoFe(3)S(4)(PEt(3))3]1+ and edge-bridged double-cubane [(Tp)2Mo(2)Fe(6)S(8)(PEt(3))4] with cyanide in acetonitrile affords [(Tp)MoFe(3)S(4)(CN)3]2- (2) and [(Tp)2Mo(2)Fe(6)S(8)(CN)4]4- (5), respectively. Reduction of 2 with KC(14)H(10) yields [(Tp)MoFe(3)S(4)(CN)3]3- (3). Clusters were isolated in approximately 70-90% yields as Et(4)N+ or Bu(4)N+ salts; clusters 3 and 5 contain all-ferrous cores, and 3 is the first [MoFe(3)S(4)]1+ cluster isolated in substance. The structures of 2 and 3 are very similar; the volume of the reduced cluster core is slightly larger (2.5%), a usual effect upon reduction of cubane-type Fe(4)S(4) and MFe(3)S(4) clusters. Redox potentials and 57Fe isomer shifts of [(Tp)MoFe(3)S(4)L3]2-,3- and [(Tp)2Mo(2)Fe(6)S(8)L(4)]4-,3- clusters with L = CN-, PhS-, halide, and PEt3 are compared. Clusters with pi-donor ligands (L = halide, PhS) exhibit larger isomer shifts and lower (more negative) redox potentials, while pi-acceptor ligands (L = CN, PEt3) induce smaller isomer shifts and higher (less-negative) redox potentials. When the potentials of 3/2 and [(Tp)MoFe(3)S(4)(SPh)3]3-/2- are compared, cyanide stabilizes 3 by 270 mV versus the reduced thiolate cluster, commensurate with the 310 mV stabilization of [Fe(4)S(4)(CN)4]4- versus [Fe(4)S(4)(SPh)4]4- where four ligands differ. These results demonstrate the efficacy of cyanide stabilization of lower cluster oxidation states. (Tp = hydrotris(pyrazolyl)borate(1-)).

Quinolinone and pyridopyrimidinone inhibitors of DNA-dependent protein kinase.

PubMed

Barbeau, Olivier R; Cano-Soumillac, Celine; Griffin, Roger J; Hardcastle, Ian R; Smith, Graeme C M; Richardson, Caroline; Clegg, William; Harrington, Ross W; Golding, Bernard T

2007-08-21

8-Substituted 2-morpholin-4-yl-quinolin-4-ones and 9-substituted 2-morpholin-4-yl-pyrido[1,2-a]pyrimidin-4-ones with selected aryl and heteroaryl groups as the substituent have been synthesised as potential inhibitors of DNA-dependent protein kinase. A multiple-parallel approach, employing Suzuki cross-coupling methodology, was utilised in the preparation of 8-substituted 2-morpholin-4-yl-quinolin-4-ones. For this purpose 8-bromo-2-morpholin-4-yl-quinolin-4-one was required as an intermediate. This compound was obtained by adapting a literature route in which thermal cyclocondensation of (2-bromoanilino)-morpholin-4-yl-5-methylene-2,2-dimethyl[1,3]dioxane-4,6-dione afforded 8-bromo-2-morpholin-4-yl-quinolin-4-one. A multiple-parallel approach, employing Suzuki cross-coupling methodology, was also utilised to prepare 9-substituted 2-morpholin-4-yl-pyrido[1,2-a]pyrimidin-4-ones using 9-hydroxy-2-morpholin-4-yl-pyrido[1,2-a]pyrimidin-4-one O-trifluoromethanesulfonate as an intermediate. 8-Substituted 2-morpholin-4-yl-quinolin-4-ones and 9-substituted 2-morpholin-4-yl-pyrido[1,2-a]pyrimidin-4-ones were both inhibitors of DNA-dependent protein kinase. When the substituent was dibenzothiophen-4-yl, dibenzofuran-4-yl or biphen-3-yl, IC50 values in the low nanomolar range were observed. Interestingly, the pyridopyrimidinones and quinolinones were essentially equipotent with the corresponding 8-substituted 2-morpholin-4-yl-chromen-4-ones previously reported (I. R. Hardcastle, X. Cockcroft, N. J. Curtin, M. Desage El-Murr, J. J. J. Leahy, M. Stockley, B. T. Golding, L. Rigoreau, C. Richardson, G. C. M. Smith and R. J. Griffin, J. Med. Chem., 2005, 48, 7829-7846).

Transcytosis of F4 fimbriae by villous and dome epithelia in F4-receptor positive pigs supports importance of receptor-dependent endocytosis in oral immunization strategies.

PubMed

Snoeck, Veerle; Van den Broeck, Wim; De Colvenaer, Veerle; Verdonck, Frank; Goddeeris, Bruno; Cox, Eric

2008-07-15

Very few antigens have been described that induce an intestinal immunity when given orally. Our laboratory demonstrated that oral administration of isolated F4 (K88) fimbriae of Escherichia coli to F4-receptor positive (F4R(+)) pigs induces protective mucosal immunity against challenge infection. However, presence of F4-receptors (F4R) on villous enterocytes is a prerequisite for inducing the immune response, as no F4-specific antibody-secreting cells (ASC) can be induced in F4R(-) pigs. In this study, the in vivo binding of isolated F4 fimbriae (F4) to the gut epithelium was examined in F4R(+) and F4R(-) pigs. It was further investigated whether binding of F4 to the F4R results in endocytosis in and translocation across the gut epithelium using microscopy. F4 did not adhere to the intestinal epithelium of F4R(-) pigs, whereas it strongly adhered to the villous epithelium and the follicle-associated epithelium (FAE) of the jejunum and ileum of F4R(+) pigs. Following binding to F4R, F4 was endocytosed by villous enterocytes, follicle-associated enterocytes and M cells. Transcytosis of F4 across the epithelium resulted in the appearance of F4 in the lamina propria and dome region of the jejunal and ileal PP. This is the first study showing transcytosis of fimbriae across the gut epithelium. This receptor-dependent transcytosis can explain the success of F4 fimbriae as oral immunogen for inducing protective immunity in F4R(+) pigs strengthening the importance of receptor-dependent endocytosis and translocation in oral vaccine strategies. Further identification of the receptor responsible for this transport is in progress.

Prime Contract Awards Over $25,000 by Major System, Contractor and State Part 1 (AAA-NAVY-AVG NAVY)

DTIC Science & Technology

1990-01-01

Q-COC’) -4 M’i (a -4 c"a(aeo - ( D 0 AC 1 -ao f-.r qva 0(%Ioa.4 ()t a. c~cv(vc4 z *Za in -0f (4Jl w -44- m - .41 C,4 Ui 0 C4 IC4 P- -a l~~II I II cLE E...AO-A236 155iiiilulll l I l 1990 ANNUAL Prime Contract Awards Over $25,000 by Major System, Contractor and State Part 1 (AAA-NAVY-AVG NAVY) WHS...Special . 1 -9 __28284 pages I1 ~ . - e21 M(%I% cm -40W -4 I4 m V .. 4 mt WC)a r a- 4-r w~l w zl- qt qt V .4- 01-4 41-4 . 40 o r Lu V) c I OL 9 C U c

Inherent Error in Asynchronous Digital Flight Controls.

DTIC Science & Technology

1980-02-01

IMAXJ DIIMENSION AP(2,2) PBIP(2v2),CP(lv2) ,FC(2,2) iGC(2,1) , PHIT ’(4,4), I HC(2v2)vEC(2w1)wPHITI(4,4,l01),PSITI(4,4),PHTAU(4,4) ,PSTAU(4,4),I 4 INJ3EX(4...1.0 4 02. CON’T I NUE [𔃺 4 11 :: 2 7NT TI =T14-E:’LTA PHITl(2yJ1,11) =0.0 4 FHIT1(2y2vlJ.) EXP(-10.*TI) [DO 400 11 = lNP DO0 400 JJ = INP 400 PHIT (IlJJ...PHIT1(IIr,J.JYN’T) WRITE(6y860) 860 FORMAT (5X Y’PH IT’) [DO 861 1 -IYiNP 1361 WRITE(6v802) ( PHIT (I9vJ) ,J:=1,NP) DO :1800 KK2 1,J.6 IAU N1

St. Louis Harbor Project Pedestrian Survey, Madison County, Illinois. St. Louis District Cultural Resource Management Reports Number 24

DTIC Science & Technology

1985-07-01

r - ON N- N a- f n" 0 E C > 00 0 0 0 0 000 Q0a aa0C oa0 000 0 a00 Q 0aaa00L 0. -00 -4-- - .26 v 00 04...34- rn -I ൖ ao o o o a. 4,0 , , (, -*-,4 C *44- ci+- liv 01C 0 E Ia 0 C0 I 0o -- uClJO’ - - 0Ij. I4.4D):t~~ tCaM-I-- - - 0 4- L- 4-0 r - - C 0L)- 4)LL C ... E 0 1- 0 ID E - 0+- C - L) 4v + L C I +- QL 4- 0 r z8 I-- 11 0 C4- +- L3~ I-L QL ~ 0 022 mor_( 00 Cl U)I 0%0 4- 04 4 4 63 *00 B a 4)

Approximate Reasoning and the REVEAL Software System. Users Guide.

DTIC Science & Technology

1985-03-01

Oi O O Sko mwr-r . . U~ -n APPENDIX B TACTICAL MODEL REVEAL CONTEXT *-4 u)63U .0 W -4 - 0-oLL 0 LA,- X -4 .- q 0 S... 0 03 Q C4U u r= <c El) ty E:, Ui...u .jI - k0 jC~ q ( 0t’ COr *o (0 C) V)0 r C C-r’ ko o A Ul -)- - ’ r) -UIUrU 0<D( . .* . . . . . . . . . . . (S 0< )(D< ()%D(D ( - Z C D IDC ()tD...i.N 0 0t0-400 U Uo 03 V4’U ko 0 o.... L) 4 40.). .4.4’ 403p03 L) -4 - --4 .- 4v V4 4 U)- U) 0 0U)U I u )uU) u ) - P tn V -C ) V~U)~) E -4 R -- 4

All Prime Contract Awards by State or Country, Place, and Contractor. Part 14 (Akron, New York-Wilson, North Carolina)

DTIC Science & Technology

1990-01-01

i4 i-N( 000U or- L-4ɘ 0-4 0- ɘin L-- )CO 1-00 V) 11 034 Was00 Mtn0 40 00 (90 NO inO -400 -100 ,-411 I.1 . : I Iz o I of 103 - 110 nin I -4 -I 0 in w...4 U- 103 (0< If 0 0 0000 00000000 0 00 00000000 0 : ID ::O4I 00 00 000400 000000000 00 0. ~0 000000000o 0M If M (40 < I-4 4 14 44 .. ൴ -4-4 -i1--i -4...xzz xzzzzzzz MO) :: ax ZZ OZZZZ* a) z o z Q)Zzzz* 4)z O)zz* wzzzzzzz I moo it Z z z Z z I z z z 4D I moo 11 0) QC>00 11 cn a a) PD In In ",4 *4D-qamr-m

Vibration and Temperature Survey Production AH-1G Helicopter

DTIC Science & Technology

1974-03-01

0: C - r- 00 ’ % 0 0(l be m0 a%0 i 4 N ,4 en - -.t m0 0 A V4 -n en w- .- C14N N cn M o 0n %o 0o IA 𔃺’ n co r’- t,- % m A 00o % a% en 0 w % C4 0 0; I...c4 A’ 4 O 󈧅 C4 9 WA . 04 (1--N N Y4 (n~ N N en 4 4 4 4 C C 400C N. -4 -T %D - w4 0 co 0 M 0 r- 0 NN fn r, OD N ONOD0-4 n % C6 LA r 00 41 0 C6I 11 A...iight (100) 204 and 205 Le,, el Flight (101) 206 and 207 Climb (102) 208 and 209 Descent (103) 210 and 211 Takeoff (104) 212 and 213 Landing (105) 214 and

One barbiturate and two solvated thiobarbiturates containing the triply hydrogen-bonded ADA/DAD synthon, plus one ansolvate and three solvates of their coformer 2,4-diaminopyrimidine.

PubMed

Hützler, Wilhelm Maximilian; Egert, Ernst; Bolte, Michael

2016-09-01

A path to new synthons for application in crystal engineering is the replacement of a strong hydrogen-bond acceptor, like a C=O group, with a weaker acceptor, like a C=S group, in doubly or triply hydrogen-bonded synthons. For instance, if the C=O group at the 2-position of barbituric acid is changed into a C=S group, 2-thiobarbituric acid is obtained. Each of the compounds comprises two ADA hydrogen-bonding sites (D = donor and A = acceptor). We report the results of cocrystallization experiments of barbituric acid and 2-thiobarbituric acid, respectively, with 2,4-diaminopyrimidine, which contains a complementary DAD hydrogen-bonding site and is therefore capable of forming an ADA/DAD synthon with barbituric acid and 2-thiobarbituric acid. In addition, pure 2,4-diaminopyrimidine was crystallized in order to study its preferred hydrogen-bonding motifs. The experiments yielded one ansolvate of 2,4-diaminopyrimidine (pyrimidine-2,4-diamine, DAPY), C4H6N4, (I), three solvates of DAPY, namely 2,4-diaminopyrimidine-1,4-dioxane (2/1), 2C4H6N4·C4H8O2, (II), 2,4-diaminopyrimidine-N,N-dimethylacetamide (1/1), C4H6N4·C4H9NO, (III), and 2,4-diaminopyrimidine-1-methylpyrrolidin-2-one (1/1), C4H6N4·C5H9NO, (IV), one salt of barbituric acid, viz. 2,4-diaminopyrimidinium barbiturate (barbiturate is 2,4,6-trioxopyrimidin-5-ide), C4H7N4(+)·C4H3N2O3(-), (V), and two solvated salts of 2-thiobarbituric acid, viz. 2,4-diaminopyrimidinium 2-thiobarbiturate-N,N-dimethylformamide (1/2) (2-thiobarbiturate is 4,6-dioxo-2-sulfanylidenepyrimidin-5-ide), C4H7N4(+)·C4H3N2O2S(-)·2C3H7NO, (VI), and 2,4-diaminopyrimidinium 2-thiobarbiturate-N,N-dimethylacetamide (1/2), C4H7N4(+)·C4H3N2O2S(-)·2C4H9NO, (VII). The ADA/DAD synthon was succesfully formed in the salt of barbituric acid, i.e. (V), as well as in the salts of 2-thiobarbituric acid, i.e. (VI) and (VII). In the crystal structures of 2,4-diaminopyrimidine, i.e. (I)-(IV), R2(2)(8) N-H...N hydrogen-bond motifs are preferred and, in two structures, additional R3(2)(8) patterns were observed.

CERES ERBE-like Monthly Geographical Averages (ES-4) in HDF (CER_ES4_PFM+FM1_Edition1)

NASA Technical Reports Server (NTRS)

Wielicki, Bruce A. (Principal Investigator)

The ERBE-like Monthly Geographical Averages (ES-4) product contains a month of space and time averaged Clouds and the Earth's Radiant Energy System (CERES) data for a single scanner instrument. The ES-4 is also produced for combinations of scanner instruments. For each observed 2.5-degree spatial region, the daily average, the hourly average over the month, and the overall monthly average of shortwave and longwave fluxes at the Top-of-the-Atmosphere (TOA) from the CERES ES-9 product are spatially nested up from 2.5-degree regions to 5- and 10-degree regions, to 2.5-, 5-, and 10-degree zonal averages, and to global monthly averages. For each nested area, the albedo and net flux are given. For each region, the daily average flux is estimated from an algorithm that uses the available hourly data, scene identification data, and diurnal models. This algorithm is 'like' the algorithm used for the Earth Radiation Budget Experiment (ERBE). The following CERES ES4 data sets are currently available: CER_ES4_FM1+FM2_Edition1 CER_ES4_PFM+FM1+FM2_Edition1 CER_ES4_PFM+FM1+FM2_Edition2 CER_ES4_PFM+FM1_Edition1 CER_ES4_PFM+FM2_Edition1 CER_ES4_TRMM-PFM_Edition1 CER_ES4_TRMM-PFM_Edition2 CER_ES4_Terra-FM1_Edition1 CER_ES4_Terra-FM2_Edition1 CER_ES4_FM1+FM2_Edition2 CER_ES4_Terra-FM1_Edition2 CER_ES4_Terra-FM2_Edition2 CER_ES4_Aqua-FM3_Edition1 CER_ES4_Aqua-FM4_Edition1 CER_ES4_FM1+FM2+FM3+FM4_Edition1 CER_ES4_Aqua-FM3_Edition2 CER_ES4_Aqua-FM4_Edition2 CER_ES4_FM1+FM3_Edition2 CER_ES4_FM1+FM4_Edition2 CER_ES4_PFM+FM1_Edition2 CER_ES4_PFM+FM2_Edition2 CER_ES4_Aqua-FM3_Edition1-CV CER_ES4_Aqua-FM4_Edition1-CV CER_ES4_Terra-FM1_Edition1-CV CER_ES4_Terra-FM2_Edition1-CV. [Location=GLOBAL] [Temporal_Coverage: Start_Date=1998-01-01; Stop_Date=2000-03-31] [Spatial_Coverage: Southernmost_Latitude=-90; Northernmost_Latitude=90; Westernmost_Longitude=-180; Easternmost_Longitude=180] [Data_Resolution: Latitude_Resolution=2.5 degree; Longitude_Resolution=2.5 degree; Horizontal_Resolution_Range=250 km - < 500 km or approximately 2.5 degrees - < 5.0 degrees; Temporal_Resolution=1 month; Temporal_Resolution_Range=Monthly - < Annual].

CERES ERBE-like Monthly Geographical Averages (ES-4) in HDF (CER_ES4_Terra-FM2_Edition1-CV)

NASA Technical Reports Server (NTRS)

Wielicki, Bruce A. (Principal Investigator)

The ERBE-like Monthly Geographical Averages (ES-4) product contains a month of space and time averaged Clouds and the Earth's Radiant Energy System (CERES) data for a single scanner instrument. The ES-4 is also produced for combinations of scanner instruments. For each observed 2.5-degree spatial region, the daily average, the hourly average over the month, and the overall monthly average of shortwave and longwave fluxes at the Top-of-the-Atmosphere (TOA) from the CERES ES-9 product are spatially nested up from 2.5-degree regions to 5- and 10-degree regions, to 2.5-, 5-, and 10-degree zonal averages, and to global monthly averages. For each nested area, the albedo and net flux are given. For each region, the daily average flux is estimated from an algorithm that uses the available hourly data, scene identification data, and diurnal models. This algorithm is 'like' the algorithm used for the Earth Radiation Budget Experiment (ERBE). The following CERES ES4 data sets are currently available: CER_ES4_FM1+FM2_Edition1 CER_ES4_PFM+FM1+FM2_Edition1 CER_ES4_PFM+FM1+FM2_Edition2 CER_ES4_PFM+FM1_Edition1 CER_ES4_PFM+FM2_Edition1 CER_ES4_TRMM-PFM_Edition1 CER_ES4_TRMM-PFM_Edition2 CER_ES4_Terra-FM1_Edition1 CER_ES4_Terra-FM2_Edition1 CER_ES4_FM1+FM2_Edition2 CER_ES4_Terra-FM1_Edition2 CER_ES4_Terra-FM2_Edition2 CER_ES4_Aqua-FM3_Edition1 CER_ES4_Aqua-FM4_Edition1 CER_ES4_FM1+FM2+FM3+FM4_Edition1 CER_ES4_Aqua-FM3_Edition2 CER_ES4_Aqua-FM4_Edition2 CER_ES4_FM1+FM3_Edition2 CER_ES4_FM1+FM4_Edition2 CER_ES4_PFM+FM1_Edition2 CER_ES4_PFM+FM2_Edition2 CER_ES4_Aqua-FM3_Edition1-CV CER_ES4_Aqua-FM4_Edition1-CV CER_ES4_Terra-FM1_Edition1-CV CER_ES4_Terra-FM2_Edition1-CV. [Location=GLOBAL] [Temporal_Coverage: Start_Date=1998-01-01; Stop_Date=2006-10-31] [Spatial_Coverage: Southernmost_Latitude=-90; Northernmost_Latitude=90; Westernmost_Longitude=-180; Easternmost_Longitude=180] [Data_Resolution: Latitude_Resolution=2.5 degree; Longitude_Resolution=2.5 degree; Horizontal_Resolution_Range=250 km - < 500 km or approximately 2.5 degrees - < 5.0 degrees; Temporal_Resolution=1 month; Temporal_Resolution_Range=Monthly - < Annual].

CERES ERBE-like Monthly Geographical Averages (ES-4) in HDF (CER_ES4_Aqua-FM3_Edition1)

NASA Technical Reports Server (NTRS)

Wielicki, Bruce A. (Principal Investigator)

The ERBE-like Monthly Geographical Averages (ES-4) product contains a month of space and time averaged Clouds and the Earth's Radiant Energy System (CERES) data for a single scanner instrument. The ES-4 is also produced for combinations of scanner instruments. For each observed 2.5-degree spatial region, the daily average, the hourly average over the month, and the overall monthly average of shortwave and longwave fluxes at the Top-of-the-Atmosphere (TOA) from the CERES ES-9 product are spatially nested up from 2.5-degree regions to 5- and 10-degree regions, to 2.5-, 5-, and 10-degree zonal averages, and to global monthly averages. For each nested area, the albedo and net flux are given. For each region, the daily average flux is estimated from an algorithm that uses the available hourly data, scene identification data, and diurnal models. This algorithm is 'like' the algorithm used for the Earth Radiation Budget Experiment (ERBE). The following CERES ES4 data sets are currently available: CER_ES4_FM1+FM2_Edition1 CER_ES4_PFM+FM1+FM2_Edition1 CER_ES4_PFM+FM1+FM2_Edition2 CER_ES4_PFM+FM1_Edition1 CER_ES4_PFM+FM2_Edition1 CER_ES4_TRMM-PFM_Edition1 CER_ES4_TRMM-PFM_Edition2 CER_ES4_Terra-FM1_Edition1 CER_ES4_Terra-FM2_Edition1 CER_ES4_FM1+FM2_Edition2 CER_ES4_Terra-FM1_Edition2 CER_ES4_Terra-FM2_Edition2 CER_ES4_Aqua-FM3_Edition1 CER_ES4_Aqua-FM4_Edition1 CER_ES4_FM1+FM2+FM3+FM4_Edition1 CER_ES4_Aqua-FM3_Edition2 CER_ES4_Aqua-FM4_Edition2 CER_ES4_FM1+FM3_Edition2 CER_ES4_FM1+FM4_Edition2 CER_ES4_PFM+FM1_Edition2 CER_ES4_PFM+FM2_Edition2 CER_ES4_Aqua-FM3_Edition1-CV CER_ES4_Aqua-FM4_Edition1-CV CER_ES4_Terra-FM1_Edition1-CV CER_ES4_Terra-FM2_Edition1-CV. [Location=GLOBAL] [Temporal_Coverage: Start_Date=1998-01-01; Stop_Date=2005-10-31] [Spatial_Coverage: Southernmost_Latitude=-90; Northernmost_Latitude=90; Westernmost_Longitude=-180; Easternmost_Longitude=180] [Data_Resolution: Latitude_Resolution=2.5 degree; Longitude_Resolution=2.5 degree; Horizontal_Resolution_Range=250 km - < 500 km or approximately 2.5 degrees - < 5.0 degrees; Temporal_Resolution=1 month; Temporal_Resolution_Range=Monthly - < Annual].

CERES ERBE-like Monthly Geographical Averages (ES-4) in HDF (CER_ES4_Aqua-FM3_Edition2)

NASA Technical Reports Server (NTRS)

Wielicki, Bruce A. (Principal Investigator)

The ERBE-like Monthly Geographical Averages (ES-4) product contains a month of space and time averaged Clouds and the Earth's Radiant Energy System (CERES) data for a single scanner instrument. The ES-4 is also produced for combinations of scanner instruments. For each observed 2.5-degree spatial region, the daily average, the hourly average over the month, and the overall monthly average of shortwave and longwave fluxes at the Top-of-the-Atmosphere (TOA) from the CERES ES-9 product are spatially nested up from 2.5-degree regions to 5- and 10-degree regions, to 2.5-, 5-, and 10-degree zonal averages, and to global monthly averages. For each nested area, the albedo and net flux are given. For each region, the daily average flux is estimated from an algorithm that uses the available hourly data, scene identification data, and diurnal models. This algorithm is 'like' the algorithm used for the Earth Radiation Budget Experiment (ERBE). The following CERES ES4 data sets are currently available: CER_ES4_FM1+FM2_Edition1 CER_ES4_PFM+FM1+FM2_Edition1 CER_ES4_PFM+FM1+FM2_Edition2 CER_ES4_PFM+FM1_Edition1 CER_ES4_PFM+FM2_Edition1 CER_ES4_TRMM-PFM_Edition1 CER_ES4_TRMM-PFM_Edition2 CER_ES4_Terra-FM1_Edition1 CER_ES4_Terra-FM2_Edition1 CER_ES4_FM1+FM2_Edition2 CER_ES4_Terra-FM1_Edition2 CER_ES4_Terra-FM2_Edition2 CER_ES4_Aqua-FM3_Edition1 CER_ES4_Aqua-FM4_Edition1 CER_ES4_FM1+FM2+FM3+FM4_Edition1 CER_ES4_Aqua-FM3_Edition2 CER_ES4_Aqua-FM4_Edition2 CER_ES4_FM1+FM3_Edition2 CER_ES4_FM1+FM4_Edition2 CER_ES4_PFM+FM1_Edition2 CER_ES4_PFM+FM2_Edition2 CER_ES4_Aqua-FM3_Edition1-CV CER_ES4_Aqua-FM4_Edition1-CV CER_ES4_Terra-FM1_Edition1-CV CER_ES4_Terra-FM2_Edition1-CV. [Location=GLOBAL] [Temporal_Coverage: Start_Date=1998-01-01; Stop_Date=2005-12-31] [Spatial_Coverage: Southernmost_Latitude=-90; Northernmost_Latitude=90; Westernmost_Longitude=-180; Easternmost_Longitude=180] [Data_Resolution: Latitude_Resolution=2.5 degree; Longitude_Resolution=2.5 degree; Horizontal_Resolution_Range=250 km - < 500 km or approximately 2.5 degrees - < 5.0 degrees; Temporal_Resolution=1 month; Temporal_Resolution_Range=Monthly - < Annual].

CERES ERBE-like Monthly Geographical Averages (ES-4) in HDF (CER_ES4_FM1+FM2_Edition1)

NASA Technical Reports Server (NTRS)

Wielicki, Bruce A. (Principal Investigator)

The ERBE-like Monthly Geographical Averages (ES-4) product contains a month of space and time averaged Clouds and the Earth's Radiant Energy System (CERES) data for a single scanner instrument. The ES-4 is also produced for combinations of scanner instruments. For each observed 2.5-degree spatial region, the daily average, the hourly average over the month, and the overall monthly average of shortwave and longwave fluxes at the Top-of-the-Atmosphere (TOA) from the CERES ES-9 product are spatially nested up from 2.5-degree regions to 5- and 10-degree regions, to 2.5-, 5-, and 10-degree zonal averages, and to global monthly averages. For each nested area, the albedo and net flux are given. For each region, the daily average flux is estimated from an algorithm that uses the available hourly data, scene identification data, and diurnal models. This algorithm is 'like' the algorithm used for the Earth Radiation Budget Experiment (ERBE). The following CERES ES4 data sets are currently available: CER_ES4_FM1+FM2_Edition1 CER_ES4_PFM+FM1+FM2_Edition1 CER_ES4_PFM+FM1+FM2_Edition2 CER_ES4_PFM+FM1_Edition1 CER_ES4_PFM+FM2_Edition1 CER_ES4_TRMM-PFM_Edition1 CER_ES4_TRMM-PFM_Edition2 CER_ES4_Terra-FM1_Edition1 CER_ES4_Terra-FM2_Edition1 CER_ES4_FM1+FM2_Edition2 CER_ES4_Terra-FM1_Edition2 CER_ES4_Terra-FM2_Edition2 CER_ES4_Aqua-FM3_Edition1 CER_ES4_Aqua-FM4_Edition1 CER_ES4_FM1+FM2+FM3+FM4_Edition1 CER_ES4_Aqua-FM3_Edition2 CER_ES4_Aqua-FM4_Edition2 CER_ES4_FM1+FM3_Edition2 CER_ES4_FM1+FM4_Edition2 CER_ES4_PFM+FM1_Edition2 CER_ES4_PFM+FM2_Edition2 CER_ES4_Aqua-FM3_Edition1-CV CER_ES4_Aqua-FM4_Edition1-CV CER_ES4_Terra-FM1_Edition1-CV CER_ES4_Terra-FM2_Edition1-CV. [Location=GLOBAL] [Temporal_Coverage: Start_Date=1998-01-01; Stop_Date=2003-12-31] [Spatial_Coverage: Southernmost_Latitude=-90; Northernmost_Latitude=90; Westernmost_Longitude=-180; Easternmost_Longitude=180] [Data_Resolution: Latitude_Resolution=2.5 degree; Longitude_Resolution=2.5 degree; Horizontal_Resolution_Range=250 km - < 500 km or approximately 2.5 degrees - < 5.0 degrees; Temporal_Resolution=1 month; Temporal_Resolution_Range=Monthly - < Annual].

CERES ERBE-like Monthly Geographical Averages (ES-4) in HDF (CER_ES4_Terra-FM1_Edition2)

NASA Technical Reports Server (NTRS)

Wielicki, Bruce A. (Principal Investigator)

The ERBE-like Monthly Geographical Averages (ES-4) product contains a month of space and time averaged Clouds and the Earth's Radiant Energy System (CERES) data for a single scanner instrument. The ES-4 is also produced for combinations of scanner instruments. For each observed 2.5-degree spatial region, the daily average, the hourly average over the month, and the overall monthly average of shortwave and longwave fluxes at the Top-of-the-Atmosphere (TOA) from the CERES ES-9 product are spatially nested up from 2.5-degree regions to 5- and 10-degree regions, to 2.5-, 5-, and 10-degree zonal averages, and to global monthly averages. For each nested area, the albedo and net flux are given. For each region, the daily average flux is estimated from an algorithm that uses the available hourly data, scene identification data, and diurnal models. This algorithm is 'like' the algorithm used for the Earth Radiation Budget Experiment (ERBE). The following CERES ES4 data sets are currently available: CER_ES4_FM1+FM2_Edition1 CER_ES4_PFM+FM1+FM2_Edition1 CER_ES4_PFM+FM1+FM2_Edition2 CER_ES4_PFM+FM1_Edition1 CER_ES4_PFM+FM2_Edition1 CER_ES4_TRMM-PFM_Edition1 CER_ES4_TRMM-PFM_Edition2 CER_ES4_Terra-FM1_Edition1 CER_ES4_Terra-FM2_Edition1 CER_ES4_FM1+FM2_Edition2 CER_ES4_Terra-FM1_Edition2 CER_ES4_Terra-FM2_Edition2 CER_ES4_Aqua-FM3_Edition1 CER_ES4_Aqua-FM4_Edition1 CER_ES4_FM1+FM2+FM3+FM4_Edition1 CER_ES4_Aqua-FM3_Edition2 CER_ES4_Aqua-FM4_Edition2 CER_ES4_FM1+FM3_Edition2 CER_ES4_FM1+FM4_Edition2 CER_ES4_PFM+FM1_Edition2 CER_ES4_PFM+FM2_Edition2 CER_ES4_Aqua-FM3_Edition1-CV CER_ES4_Aqua-FM4_Edition1-CV CER_ES4_Terra-FM1_Edition1-CV CER_ES4_Terra-FM2_Edition1-CV. [Location=GLOBAL] [Temporal_Coverage: Start_Date=1998-01-01; Stop_Date=2005-12-31] [Spatial_Coverage: Southernmost_Latitude=-90; Northernmost_Latitude=90; Westernmost_Longitude=-180; Easternmost_Longitude=180] [Data_Resolution: Latitude_Resolution=2.5 degree; Longitude_Resolution=2.5 degree; Horizontal_Resolution_Range=250 km - < 500 km or approximately 2.5 degrees - < 5.0 degrees; Temporal_Resolution=1 month; Temporal_Resolution_Range=Monthly - < Annual].

CERES ERBE-like Monthly Geographical Averages (ES-4) in HDF (CER_ES4_Terra-FM2_Edition1)

NASA Technical Reports Server (NTRS)

Wielicki, Bruce A. (Principal Investigator)

The ERBE-like Monthly Geographical Averages (ES-4) product contains a month of space and time averaged Clouds and the Earth's Radiant Energy System (CERES) data for a single scanner instrument. The ES-4 is also produced for combinations of scanner instruments. For each observed 2.5-degree spatial region, the daily average, the hourly average over the month, and the overall monthly average of shortwave and longwave fluxes at the Top-of-the-Atmosphere (TOA) from the CERES ES-9 product are spatially nested up from 2.5-degree regions to 5- and 10-degree regions, to 2.5-, 5-, and 10-degree zonal averages, and to global monthly averages. For each nested area, the albedo and net flux are given. For each region, the daily average flux is estimated from an algorithm that uses the available hourly data, scene identification data, and diurnal models. This algorithm is 'like' the algorithm used for the Earth Radiation Budget Experiment (ERBE). The following CERES ES4 data sets are currently available: CER_ES4_FM1+FM2_Edition1 CER_ES4_PFM+FM1+FM2_Edition1 CER_ES4_PFM+FM1+FM2_Edition2 CER_ES4_PFM+FM1_Edition1 CER_ES4_PFM+FM2_Edition1 CER_ES4_TRMM-PFM_Edition1 CER_ES4_TRMM-PFM_Edition2 CER_ES4_Terra-FM1_Edition1 CER_ES4_Terra-FM2_Edition1 CER_ES4_FM1+FM2_Edition2 CER_ES4_Terra-FM1_Edition2 CER_ES4_Terra-FM2_Edition2 CER_ES4_Aqua-FM3_Edition1 CER_ES4_Aqua-FM4_Edition1 CER_ES4_FM1+FM2+FM3+FM4_Edition1 CER_ES4_Aqua-FM3_Edition2 CER_ES4_Aqua-FM4_Edition2 CER_ES4_FM1+FM3_Edition2 CER_ES4_FM1+FM4_Edition2 CER_ES4_PFM+FM1_Edition2 CER_ES4_PFM+FM2_Edition2 CER_ES4_Aqua-FM3_Edition1-CV CER_ES4_Aqua-FM4_Edition1-CV CER_ES4_Terra-FM1_Edition1-CV CER_ES4_Terra-FM2_Edition1-CV. [Location=GLOBAL] [Temporal_Coverage: Start_Date=1998-01-01; Stop_Date=2005-10-31] [Spatial_Coverage: Southernmost_Latitude=-90; Northernmost_Latitude=90; Westernmost_Longitude=-180; Easternmost_Longitude=180] [Data_Resolution: Latitude_Resolution=2.5 degree; Longitude_Resolution=2.5 degree; Horizontal_Resolution_Range=250 km - < 500 km or approximately 2.5 degrees - < 5.0 degrees; Temporal_Resolution=1 month; Temporal_Resolution_Range=Monthly - < Annual].

CERES ERBE-like Monthly Geographical Averages (ES-4) in HDF (CER_ES4_Terra-FM1_Edition1)

NASA Technical Reports Server (NTRS)

Wielicki, Bruce A. (Principal Investigator)

The ERBE-like Monthly Geographical Averages (ES-4) product contains a month of space and time averaged Clouds and the Earth's Radiant Energy System (CERES) data for a single scanner instrument. The ES-4 is also produced for combinations of scanner instruments. For each observed 2.5-degree spatial region, the daily average, the hourly average over the month, and the overall monthly average of shortwave and longwave fluxes at the Top-of-the-Atmosphere (TOA) from the CERES ES-9 product are spatially nested up from 2.5-degree regions to 5- and 10-degree regions, to 2.5-, 5-, and 10-degree zonal averages, and to global monthly averages. For each nested area, the albedo and net flux are given. For each region, the daily average flux is estimated from an algorithm that uses the available hourly data, scene identification data, and diurnal models. This algorithm is 'like' the algorithm used for the Earth Radiation Budget Experiment (ERBE). The following CERES ES4 data sets are currently available: CER_ES4_FM1+FM2_Edition1 CER_ES4_PFM+FM1+FM2_Edition1 CER_ES4_PFM+FM1+FM2_Edition2 CER_ES4_PFM+FM1_Edition1 CER_ES4_PFM+FM2_Edition1 CER_ES4_TRMM-PFM_Edition1 CER_ES4_TRMM-PFM_Edition2 CER_ES4_Terra-FM1_Edition1 CER_ES4_Terra-FM2_Edition1 CER_ES4_FM1+FM2_Edition2 CER_ES4_Terra-FM1_Edition2 CER_ES4_Terra-FM2_Edition2 CER_ES4_Aqua-FM3_Edition1 CER_ES4_Aqua-FM4_Edition1 CER_ES4_FM1+FM2+FM3+FM4_Edition1 CER_ES4_Aqua-FM3_Edition2 CER_ES4_Aqua-FM4_Edition2 CER_ES4_FM1+FM3_Edition2 CER_ES4_FM1+FM4_Edition2 CER_ES4_PFM+FM1_Edition2 CER_ES4_PFM+FM2_Edition2 CER_ES4_Aqua-FM3_Edition1-CV CER_ES4_Aqua-FM4_Edition1-CV CER_ES4_Terra-FM1_Edition1-CV CER_ES4_Terra-FM2_Edition1-CV. [Location=GLOBAL] [Temporal_Coverage: Start_Date=1998-01-01; Stop_Date=2005-10-31] [Spatial_Coverage: Southernmost_Latitude=-90; Northernmost_Latitude=90; Westernmost_Longitude=-180; Easternmost_Longitude=180] [Data_Resolution: Latitude_Resolution=2.5 degree; Longitude_Resolution=2.5 degree; Horizontal_Resolution_Range=250 km - < 500 km or approximately 2.5 degrees - < 5.0 degrees; Temporal_Resolution=1 month; Temporal_Resolution_Range=Monthly - < Annual].

CERES ERBE-like Monthly Geographical Averages (ES-4) in HDF (CER_ES4_PFM+FM2_Edition1)

NASA Technical Reports Server (NTRS)

Wielicki, Bruce A. (Principal Investigator)

The ERBE-like Monthly Geographical Averages (ES-4) product contains a month of space and time averaged Clouds and the Earth's Radiant Energy System (CERES) data for a single scanner instrument. The ES-4 is also produced for combinations of scanner instruments. For each observed 2.5-degree spatial region, the daily average, the hourly average over the month, and the overall monthly average of shortwave and longwave fluxes at the Top-of-the-Atmosphere (TOA) from the CERES ES-9 product are spatially nested up from 2.5-degree regions to 5- and 10-degree regions, to 2.5-, 5-, and 10-degree zonal averages, and to global monthly averages. For each nested area, the albedo and net flux are given. For each region, the daily average flux is estimated from an algorithm that uses the available hourly data, scene identification data, and diurnal models. This algorithm is 'like' the algorithm used for the Earth Radiation Budget Experiment (ERBE). The following CERES ES4 data sets are currently available: CER_ES4_FM1+FM2_Edition1 CER_ES4_PFM+FM1+FM2_Edition1 CER_ES4_PFM+FM1+FM2_Edition2 CER_ES4_PFM+FM1_Edition1 CER_ES4_PFM+FM2_Edition1 CER_ES4_TRMM-PFM_Edition1 CER_ES4_TRMM-PFM_Edition2 CER_ES4_Terra-FM1_Edition1 CER_ES4_Terra-FM2_Edition1 CER_ES4_FM1+FM2_Edition2 CER_ES4_Terra-FM1_Edition2 CER_ES4_Terra-FM2_Edition2 CER_ES4_Aqua-FM3_Edition1 CER_ES4_Aqua-FM4_Edition1 CER_ES4_FM1+FM2+FM3+FM4_Edition1 CER_ES4_Aqua-FM3_Edition2 CER_ES4_Aqua-FM4_Edition2 CER_ES4_FM1+FM3_Edition2 CER_ES4_FM1+FM4_Edition2 CER_ES4_PFM+FM1_Edition2 CER_ES4_PFM+FM2_Edition2 CER_ES4_Aqua-FM3_Edition1-CV CER_ES4_Aqua-FM4_Edition1-CV CER_ES4_Terra-FM1_Edition1-CV CER_ES4_Terra-FM2_Edition1-CV. [Location=GLOBAL] [Temporal_Coverage: Start_Date=1998-01-01; Stop_Date=2000-03-31] [Spatial_Coverage: Southernmost_Latitude=-90; Northernmost_Latitude=90; Westernmost_Longitude=-180; Easternmost_Longitude=180] [Data_Resolution: Latitude_Resolution=2.5 degree; Longitude_Resolution=2.5 degree; Horizontal_Resolution_Range=250 km - < 500 km or approximately 2.5 degrees - < 5.0 degrees; Temporal_Resolution=1 month; Temporal_Resolution_Range=Monthly - < Annual].

CERES ERBE-like Monthly Geographical Averages (ES-4) in HDF (CER_ES4_FM1+FM2_Edition2)

NASA Technical Reports Server (NTRS)

Wielicki, Bruce A. (Principal Investigator)

The ERBE-like Monthly Geographical Averages (ES-4) product contains a month of space and time averaged Clouds and the Earth's Radiant Energy System (CERES) data for a single scanner instrument. The ES-4 is also produced for combinations of scanner instruments. For each observed 2.5-degree spatial region, the daily average, the hourly average over the month, and the overall monthly average of shortwave and longwave fluxes at the Top-of-the-Atmosphere (TOA) from the CERES ES-9 product are spatially nested up from 2.5-degree regions to 5- and 10-degree regions, to 2.5-, 5-, and 10-degree zonal averages, and to global monthly averages. For each nested area, the albedo and net flux are given. For each region, the daily average flux is estimated from an algorithm that uses the available hourly data, scene identification data, and diurnal models. This algorithm is 'like' the algorithm used for the Earth Radiation Budget Experiment (ERBE). The following CERES ES4 data sets are currently available: CER_ES4_FM1+FM2_Edition1 CER_ES4_PFM+FM1+FM2_Edition1 CER_ES4_PFM+FM1+FM2_Edition2 CER_ES4_PFM+FM1_Edition1 CER_ES4_PFM+FM2_Edition1 CER_ES4_TRMM-PFM_Edition1 CER_ES4_TRMM-PFM_Edition2 CER_ES4_Terra-FM1_Edition1 CER_ES4_Terra-FM2_Edition1 CER_ES4_FM1+FM2_Edition2 CER_ES4_Terra-FM1_Edition2 CER_ES4_Terra-FM2_Edition2 CER_ES4_Aqua-FM3_Edition1 CER_ES4_Aqua-FM4_Edition1 CER_ES4_FM1+FM2+FM3+FM4_Edition1 CER_ES4_Aqua-FM3_Edition2 CER_ES4_Aqua-FM4_Edition2 CER_ES4_FM1+FM3_Edition2 CER_ES4_FM1+FM4_Edition2 CER_ES4_PFM+FM1_Edition2 CER_ES4_PFM+FM2_Edition2 CER_ES4_Aqua-FM3_Edition1-CV CER_ES4_Aqua-FM4_Edition1-CV CER_ES4_Terra-FM1_Edition1-CV CER_ES4_Terra-FM2_Edition1-CV. [Location=GLOBAL] [Temporal_Coverage: Start_Date=1998-01-01; Stop_Date=2002-12-31] [Spatial_Coverage: Southernmost_Latitude=-90; Northernmost_Latitude=90; Westernmost_Longitude=-180; Easternmost_Longitude=180] [Data_Resolution: Latitude_Resolution=2.5 degree; Longitude_Resolution=2.5 degree; Horizontal_Resolution_Range=250 km - < 500 km or approximately 2.5 degrees - < 5.0 degrees; Temporal_Resolution=1 month; Temporal_Resolution_Range=Monthly - < Annual].

CERES ERBE-like Monthly Geographical Averages (ES-4) in HDF (CER_ES4_FM1+FM3_Edition2)

NASA Technical Reports Server (NTRS)

Wielicki, Bruce A. (Principal Investigator)

The ERBE-like Monthly Geographical Averages (ES-4) product contains a month of space and time averaged Clouds and the Earth's Radiant Energy System (CERES) data for a single scanner instrument. The ES-4 is also produced for combinations of scanner instruments. For each observed 2.5-degree spatial region, the daily average, the hourly average over the month, and the overall monthly average of shortwave and longwave fluxes at the Top-of-the-Atmosphere (TOA) from the CERES ES-9 product are spatially nested up from 2.5-degree regions to 5- and 10-degree regions, to 2.5-, 5-, and 10-degree zonal averages, and to global monthly averages. For each nested area, the albedo and net flux are given. For each region, the daily average flux is estimated from an algorithm that uses the available hourly data, scene identification data, and diurnal models. This algorithm is 'like' the algorithm used for the Earth Radiation Budget Experiment (ERBE). The following CERES ES4 data sets are currently available: CER_ES4_FM1+FM2_Edition1 CER_ES4_PFM+FM1+FM2_Edition1 CER_ES4_PFM+FM1+FM2_Edition2 CER_ES4_PFM+FM1_Edition1 CER_ES4_PFM+FM2_Edition1 CER_ES4_TRMM-PFM_Edition1 CER_ES4_TRMM-PFM_Edition2 CER_ES4_Terra-FM1_Edition1 CER_ES4_Terra-FM2_Edition1 CER_ES4_FM1+FM2_Edition2 CER_ES4_Terra-FM1_Edition2 CER_ES4_Terra-FM2_Edition2 CER_ES4_Aqua-FM3_Edition1 CER_ES4_Aqua-FM4_Edition1 CER_ES4_FM1+FM2+FM3+FM4_Edition1 CER_ES4_Aqua-FM3_Edition2 CER_ES4_Aqua-FM4_Edition2 CER_ES4_FM1+FM3_Edition2 CER_ES4_FM1+FM4_Edition2 CER_ES4_PFM+FM1_Edition2 CER_ES4_PFM+FM2_Edition2 CER_ES4_Aqua-FM3_Edition1-CV CER_ES4_Aqua-FM4_Edition1-CV CER_ES4_Terra-FM1_Edition1-CV CER_ES4_Terra-FM2_Edition1-CV. [Location=GLOBAL] [Temporal_Coverage: Start_Date=1998-01-01; Stop_Date=2005-12-31] [Spatial_Coverage: Southernmost_Latitude=-90; Northernmost_Latitude=90; Westernmost_Longitude=-180; Easternmost_Longitude=180] [Data_Resolution: Latitude_Resolution=2.5 degree; Longitude_Resolution=2.5 degree; Horizontal_Resolution_Range=250 km - < 500 km or approximately 2.5 degrees - < 5.0 degrees; Temporal_Resolution=1 month; Temporal_Resolution_Range=Monthly - < Annual].

Selective P4 Activation by a Highly Reduced Cobaltate: Synthesis of Dicobalt Tetraphosphido Complexes.

PubMed

Pelties, Stefan; Maier, Thomas; Herrmann, Dirk; de Bruin, Bas; Rebreyend, Christophe; Gärtner, Stefanie; Shenderovich, Ilya G; Wolf, Robert

2017-05-02

Although the chemistry of transition metal polyphosphide anions has attracted significant attention, there are few reports of studies in which such species have been synthesized directly from white phosphorus. [K(OEt 2 ) 2 {Co(BIAN)(cod)}] (1, BIAN=1,2-bis(2,6-diisopropylphenylimino)acenaphthene, cod=1,5-cyclooctadiene), which is readily prepared by ligand exchange from [K(thf) x {Co(cod) 2 }], reacts with P 4 to afford [{K(thf)} 2 {(BIAN)Co} 2 (μ-η 4 :η 4 -P 4 )] (2 a) in 61 % yield (isolated product). [{K(OEt 2 )} 2 {(BIAN)Co} 2 (μ-η 4 :η 4 -P 4 )] (2 b) and [K([18]crown-6)(MeCN)] 2 [{(BIAN)Co} 2 (μ-η 4 :η 4 -P 4 )] (2 c) were obtained by recrystallizing 2 a from diethyl ether and acetonitrile (and using [18]crown-6 in case of 2 c). Oxidation of 2 a with [Cp 2 Fe]BAr F 4 (one equivalent) and subsequent recrystallization of the product from different solvents gave [K(OEt 2 ){(BIAN)Co} 2 (μ-η 4 :η 4 -P 4 )] (3 a) and [K(dme) 4 ][{(BIAN)Co} 2 (μ-η 4 :η 4 -P 4 )] (3 b; dme=1,2-dimethoxyethane). Neutral [{(BIAN)Co} 2 (μ-η 4 :η 4 -P 4 )] (4) was obtained in moderate yield by oxidizing 2 a with two equivalents of [Cp 2 Fe]BAr F 4 . The new complexes were characterized by NMR, EPR (in the case of 3 a), and UV/Vis spectroscopy, and elemental analysis. The molecular structures revealed by X-ray crystallography display planar cyclic or open-chain P 4 4- units sandwiched between {(BIAN)Co} fragments. © 2017 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.

Role of IL-4 receptor α-positive CD4(+) T cells in chronic airway hyperresponsiveness.

PubMed

Kirstein, Frank; Nieuwenhuizen, Natalie E; Jayakumar, Jaisubash; Horsnell, William G C; Brombacher, Frank

2016-06-01

TH2 cells and their cytokines are associated with allergic asthma in human subjects and with mouse models of allergic airway disease. IL-4 signaling through the IL-4 receptor α (IL-4Rα) chain on CD4(+) T cells leads to TH2 cell differentiation in vitro, implying that IL-4Rα-responsive CD4(+) T cells are critical for the induction of allergic asthma. However, mechanisms regulating acute and chronic allergen-specific TH2 responses in vivo remain incompletely understood. This study defines the requirements for IL-4Rα-responsive CD4(+) T cells and the IL-4Rα ligands IL-4 and IL-13 in the development of allergen-specific TH2 responses during the onset and chronic phase of experimental allergic airway disease. Development of acute and chronic ovalbumin (OVA)-induced allergic asthma was assessed weekly in CD4(+) T cell-specific IL-4Rα-deficient BALB/c mice (Lck(cre)IL-4Rα(-/lox)) and respective control mice in the presence or absence of IL-4 or IL-13. During acute allergic airway disease, IL-4 deficiency did not prevent the onset of TH2 immune responses and OVA-induced airway hyperresponsiveness or goblet cell hyperplasia, irrespective of the presence or absence of IL-4Rα-responsive CD4(+) T cells. In contrast, deficiency of IL-13 prevented allergic asthma, irrespective of the presence or absence of IL-4Rα-responsive CD4(+) T cells. Importantly, chronic allergic inflammation and airway hyperresponsiveness were dependent on IL-4Rα-responsive CD4(+) T cells. Deficiency in IL-4Rα-responsive CD4(+) T cells resulted in increased numbers of IL-17-producing T cells and, consequently, increased airway neutrophilia. IL-4-responsive T helper cells are dispensable for acute OVA-induced airway disease but crucial in maintaining chronic asthmatic pathology. Copyright © 2015 American Academy of Allergy, Asthma & Immunology. Published by Elsevier Inc. All rights reserved.

32 CFR 1633.1 - Classifying authority.

Code of Federal Regulations, 2011 CFR

2011-07-01

... certified him to be a member of an armed force or reserve component thereof. (b) The National Selective..., 4-A, 4-A-A, 4-B, 4-C, 4-F, 4-G, 4-T or 4-W for which he is eligible upon request by the registrant...

40 CFR 180.403 - Thidiazuron; tolerances for residues.

Code of Federal Regulations, 2011 CFR

2011-07-01

... 0.4 Cattle, meat byproducts 0.4 Cotton, gin byproducts 24.0 Cotton, undelinted seed 0.3 Goat, fat 0.4 Goat, meat 0.4 Goat, meat byproducts 0.4 Hog, fat 0.4 Hog, meat 0.4 Hog, meat byproducts 0.4 Horse...

4-Nitroquinoline-1-oxide effects human lung adenocarcinoma A549 cells by regulating the expression of POLD4

PubMed Central

HUANG, QIN-MIAO; ZENG, YI-MING; ZHANG, HUA-PING; LV, LIANG-CHAO; YANG, DONG-YONG; LIN, HUI-HUANG

2016-01-01

The aim of the present study was to explore the expression of POLD4 in human lung adenocarcinoma A549 cells under 4-nitroquinoline-1-oxide (4NQO) stimulation to investigate the role of POLD4 in smoking-induced lung cancer. The lung cancer A549 cell line was treated with 4NQO, with or without MG132 (an inhibitor of proteasome activity), and subsequently the POLD4 level was determined by western blot analysis. Secondly, the cell sensitivity to 4NQO and Taxol was determined when the POLD4 expression level was downregulated by siRNA. The POLD4 protein levels in the A549 cells decreased following treatment with 4NQO; however, MG132 could reverse this phenotype. Downregulation of the POLD4 expression by siRNA enhanced A549 cell sensitivity to 4NQO, but not to Taxol. In conclusion, 4NQO affects human lung adenocarcinoma A549 cells by regulating the expression of POLD4. PMID:26998273

Ultrasonic mixing of epoxy curing agents

NASA Technical Reports Server (NTRS)

Hodges, W. T.; St.clair, T. L.

1983-01-01

A new technique for mixing solid curing agents into liquid epoxy resins using ultrasonic energy was developed. This procedure allows standard curing agents such as 4,4 prime-diaminodiphenyl sulfone (4,4 prime-DDS) and its 3,3 prime-isomer, (3,3 prime-DDS) to be mixed without prior melting of the curing agent. It also allows curing agents such as 4,4 prime-diaminodiphenyl sulfone (4,4 prime-DDS) and its 3,3 prime-isomer, (3,3 prime-DDS) to be mixed without prior melting of the curing agent. It also allows curing agents with very high melt temperatures such as 4,4 prime-diaminobenzophenone (4,4 prime-DABP) (242 C) to be mixed without premature curing. Four aromatic diamines were ultrasonically blended into MY-720 epoxy resin. These were 4,4 prime-DDS; 3,3 prime-DDA; 4,4 prime-DABP and 3,3 prime-DABP. Unfilled moldings were cast and cured for each system and their physical and mechanical properties compared.

Terminal Area Forecasts, FY 1993-2005

DTIC Science & Technology

1993-07-01

0 td U) ~ 4-) 4.J.4 0 J~ :s 0- -"C4 4o U ).4CO ) 0 u *Wý44 o 41C kdQ(n v 00 UrC~ 4) -4 0 M 0~ 4j > (D M kca 41 Ř b bO CA -A~ ..O 0 .0 Cd~ bl ~ - k...o tD ~ Hr- Nr,- `4v oH f n% oM 0( ON %D ~H w H LnODH (1 O O D DO ODG OD 00 OhOh(T ma % m %0 HC4.Ch h %Ch( i % )d% HN 4J H 1-0 %D- O M (NWN DU VO D...I ~ J)I C1 F "H OD ,- V 1 D ( -r r -4 Ch’. ON 00 -4 c,4 mu) n( (n A;1 m tD b r-4 rJ’q~~ I Nr-W L o 0 ( O HM N~ - I- IV N- M M O ’ rI % NN . OD U NCh0

The role of basic leucine zipper transcription factor E4BP4 in the immune system and immune-mediated diseases.

PubMed

Yin, Jinghua; Zhang, Jian; Lu, Qianjin

2017-07-01

Basic leucine zipper transcription factor E4BP4 (also known as NFIL3) has been implicated in the molecular and cellular mechanisms of functions and activities in mammals. The interactions between E4BP4 and major regulators of cellular processes have triggered significant interest in the roles of E4BP4 in the pathogenesis of certain chronic diseases. Indeed, novel discoveries have been emerging to illustrate the involvement of E4BP4 in multiple disorders. It is recognized that E4BP4 is extensively involved in some immune-mediated diseases, but the mechanisms of E4BP4 involvement in these complex diseases remain poorly defined. Here we review the regulatory mechanisms of E4BP4 engaging in not only the biological function but also the development of immune-mediated diseases, paving the way for future therapies. Copyright © 2017. Published by Elsevier Inc.

Structure and electrochemistry of proteins harboring iron-sulfur clusters of different nuclearities. Part II. [4Fe-4S] and [3Fe-4S] iron-sulfur proteins.

PubMed

Zanello, Piero

2018-06-01

In the context of the plethora of proteins harboring iron-sulfur clusters we have already reviewed structure/electrochemistry of metalloproteins expressing single types of iron-sulfur clusters (namely: {Fe(Cys) 4 }, {[Fe 2 S 2 ](Cys) 4 }, {[Fe 2 S 2 ](Cys) 3 (X)} (X = Asp, Arg, His), {[Fe 2 S 2 ](Cys) 2 (His) 2 }, {[Fe 3 S 4 ](Cys) 3 }, {[Fe 4 S 4 ](Cys) 4 } and {[Fe 4 S 4 ](S γ Cys ) 3 (nonthiolate ligand)} cores) and their synthetic analogs. More recently we are focussing on structure/electrochemistry of metalloproteins harboring iron-sulfur centres of different nuclearities. Having started such a subject with proteins harboring [4Fe-4S] and [2Fe-2S] clusters, we now depict the state of art of proteins containing [4Fe-4S] and [3Fe-4S] clusters. Copyright © 2018 Elsevier Inc. All rights reserved.

Projecting the Demand for Ohio River Basin Waterway Traffic Using Correlation and Regression.

DTIC Science & Technology

1979-01-01

of basic market conditions and trends. J Table 1: COMMODITY GROUPINGS TO BE UTILIZED FOR PROJECTING OHIO RIVER BASIN WATERWAY TRAFFIC COMMODITY GROUP...Tl-V t : p oMll0 4P o ’I -4C lC41,il0 0 C AL)-0 1 1 01 r iI *1. AC ,ar)a r -4. -1 ’- 1 AC AM M r l 4W .0 .0 U 4)C4 ACAM1 1’ L-10 LO0 0 0 C 4 -4 N c o...J0MC iel CJ4 V .. 4 qN M I:)r"V 41C , r Ai , ’A1,1- ’ k1 14 - oN - AcC 4p p.o N 0U I’-(l) A c OM t ~ ,Q w4 m z0 AC -a 4 . o- 0v - ;’ j0- I 414 4 4- 4

Human Factors Design Criteria for Future Systems. FAADS Design Criteria Evolving from the Sgt. York Follow-On Evaluation 1

DTIC Science & Technology

1989-05-01

and MIL-., TD -11172C. These are the most widely used documents providing human factors design criteria for the development of military systems through...4) 4bd 4)(.E c4- z - v -. r-f .r40 m 0 S -( OD Q) 0k .1 .o1 u .d 44). o- C.~) V QCf 44)) :0 J0 Al4 L .4Uv.-4 C4)LI.-44(U(E *4)4)( U . S- M 0 a *-P 4

MCTRSS Overview Functional Description

DTIC Science & Technology

1994-05-16

objectives. In a changing environment the Marine Corps must be able to record the assessment even as the assessment process is changing, Essentially...2.1.1 M[C`IRSS Potential USes 2-3 2.1.2 Current Envirominent 2-4 2.1.2.1 lunfortion Resources Management Environment 2-5 2.1.2.2 Unit Training...Flexiity 4-5 4.4 Syssem Daa 4-5 4.4.1 Iput/Otw Dat 4-5 4.4.2 DaM~ase 4-5 16 Abv 1994 vi OAmrew Fwwi5nd LDraapm TAKE OF CONUIKS 5 ENVIRONMENT 5-1 5.1

Least Cost Test Profile. Volume II.

DTIC Science & Technology

1982-04-01

LAMINATION ON WALL HAS SEPARATED. 61 A) SSRS-625B - ROOF LEAKS A LITTLE. THEY WERE CAULKED AT RIVET POINTS WITH RTV. D-12 TABLE GENERAL COMMENTS ES-57...transported in a 5 ton large truck bed because of width. Flatbed semi trailer requires two forklifts or a large crane and spreader assy to load them. G-4...1"A’d Test Inspection Paragraph Paragraph Cleaning 3.4.2 4.6.4 Welding 3.4.3 4.6.5 Lamination 3.4.4 4.6.6 Interchangeability 3.4.6 4.6.8 Riveting

Channel and Switchbox Routing Using a Greedy Based Channel Algorithm with Outward Scanning Technique.

DTIC Science & Technology

1988-12-01

ol ) V. CONCLUSION AND DISCUSSION......................... ... 6 APPENDIX A. NPGS ROUTER USER GUIDE........................6 APPENDIX B. C PROGRAM...problem and shows some of the terminology. previously mentioned. that is peculiar to VISI routing. Clq C4 C4 C4 -4 C4 Clq -4- o C CCD Co -4 q 04 -4 oL ...34 l II 92-. -.-- -.-- , -.... -4--*- -*-- tC I I + 62- -- - ----- -. .t -- +* 0C ’l i II I o -- - ..... 4+ - -+- j- - --- +-+-g9! 6 Ol ... ... "II g4

Aircraft Emissions: Potential Effects on Ozone and Climate - A Review and Progress Report

DTIC Science & Technology

1977-03-01

which itself absorbs and reemits energy over a wide spectral range. In addition to such direct effects, various possible feedback effects can be...4.3.3 COMESA Climatic Effect Studies 4-17 4.4 Computed Mean Temperature Effects--Fleet Effects 4-24 4.4.1 Introduction 4-24 4.4.2 Mean Temperature Impact ...M B-13 B-2 The Chemical Kinetic Mechanism Used In . Model A B-19 B-3 Rate Coefficients for Model B (with Activation Energy in cal/mole) B-20 B-4

Amarillo MAP, Texas. Revised Uniform Summary of Surface Weather Observations (RUSSWO). Parts A-F.

DTIC Science & Technology

1981-12-02

9 7,7 0 70&8 70, ? Dog 70*8 70,8 7Q,8 70o8 70,8 70o8 70. 70,8 70 >’AOMC 69. 70.6 71. I1.1 71.’ 71.4 71.4 71.4 71.4 71.4 71.4 71.4 71.4 7 4 71.4 71.4 a...TH.IS PORN ^ *S. . T - - -- -- -- --- - - - - - - - --- - - --- -------- V- GLOBAL CLIMATOLOGY BRANCH Ll:SAF E T AC CE~5ILIG VE SU VISIBILITY Ai

Searching for “LiCr{sup II}PO{sub 4}”

DOE Office of Scientific and Technical Information (OSTI.GOV)

Mosymow, E.; Glaum, R., E-mail: rglaum@uni-bonn.de; Kremer, R.K.

The two new phosphates LiCr{sup II}{sub 4}(PO{sub 4}){sub 3} and Li{sub 5}Cr{sup II}{sub 2}Cr{sup III}(PO{sub 4}){sub 4} are discovered as equilibrium phases (ϑ=800 °C) in the quarternary system Li/Cr/P/O. Their crystal structures have been determined from single-crystal X-ray diffraction data (LiCr{sup II}{sub 4}(PO{sub 4}){sub 3}: violet-blue, Pnma (no. 62), Z=4, a=6.175(1) Å, b=14.316(3) Å, c=10.277(2) Å, 100 parameters, R{sub 1}=0.028, wR{sub 2}=0.08, 2060 unique reflections with F{sub o}>4σ(F{sub o}); Li{sub 5}Cr{sup II}{sub 2}Cr{sup III}(PO{sub 4}){sub 4}: greyish-green, P1{sup ¯} (no. 2), Z=1, a=4.9379(7) Å, b=7.917(2) Å, c=8.426(2) Å, α=109.98(2)°, β=90.71(1)°, γ=104.91(1)°, 131 parameters, R{sub 1}=0.022, wR{sub 2}=0.067, 1594 unique reflectionsmore » with F{sub o}>4σ(F{sub o})). Li{sub 5}Cr{sup II}{sub 2}Cr{sup III}(PO{sub 4}){sub 4} adopts an hitherto unknown structure type. The crystal structure of LiCr{sup II}{sub 4}(PO{sub 4}){sub 3} is isotypic to that of NaCd{sup II}{sub 4}(PO{sub 4}){sub 3} and related to that of the mineral silicocarnotite Ca{sub 5}(PO{sub 4}){sub 2}(SiO{sub 4}). Significant disorder between Li{sup +} and Cr{sup 2+} is observed for both crystal structures. The oxidation states assigned to chromium in these two phosphates are in agreement with UV/vis/NIR absorption spectra and magnetic susceptibility data recorded for both compounds. Instead of “LiCr{sup II}PO{sub 4}” mixtures of LiCr{sup II}{sub 4}(PO{sub 4}){sub 3}, Li{sub 5}Cr{sup II}{sub 2}Cr{sup III}(PO{sub 4}){sub 4}, Cr{sub 2}O{sub 3}, and CrP are observed at equilibrium. Instead of “Li{sub 2}Cr{sup II}P{sub 2}O{sub 7}” four-phase mixtures consisting of Li{sub 9}Cr{sup III}{sub 3}(P{sub 2}O{sub 7}){sub 3}(PO{sub 4}){sub 2}, Li{sub 3}Cr{sup III}{sub 2}(PO{sub 4}){sub 3}, LiCrP{sub 2}O{sub 7}, and CrP were obtained. - Graphical abstract: Investigations on the equilibrium relations in the system Li/Cr/P/O revealed the two hitherto unknown phosphates Li{sub 5}Cr{sup II}{sub 2}Cr{sup III}(PO{sub 4}){sub 4} and LiCr{sup II}{sub 4}(PO{sub 4}){sub 3}. They form instead of “LiCr{sup II}PO{sub 4}”. The crystal structures, magnetic behavior and optical spectra of these phosphates are reported. - Highlights: • The two new phosphates Li{sub 5}Cr{sup II}{sub 2}Cr{sup III}(PO{sub 4}){sub 4} and LiCr{sup II}{sub 4}(PO{sub 4}){sub 3} have been characterized. • Optical spectra and paramagnetism of the these phosphates are explained by AOM. • Li{sub 5}Cr{sup II}{sub 2}Cr{sup III}(PO{sub 4}){sub 4}, LiCr{sup II}{sub 4}(PO{sub 4}){sub 3}, Cr{sub 2}O{sub 3}, and CrP occur instead of “LiCr{sup II}PO{sub 4}”. • LiCr{sup II}{sub 4}(PO{sub 4}){sub 3} is structurally closely related to Silicocarnotite Ca{sub 5}(PO{sub 4}){sub 2}(SiO{sub 4}). • Li{sub 5}Cr{sup II}{sub 2}Cr{sup III}(PO{sub 4}){sub 4} and LiCr{sup II}{sub 4}(PO{sub 4}){sub 3} exhibit significant cation disorder Li{sup +}/Cr{sup 2+}.« less

Searching for “LiCrIIPO4”

NASA Astrophysics Data System (ADS)

Mosymow, E.; Glaum, R.; Kremer, R. K.

2014-10-01

The two new phosphates LiCrII4(PO4)3 and Li5CrII2CrIII(PO4)4 are discovered as equilibrium phases (ϑ=800 °C) in the quarternary system Li/Cr/P/O. Their crystal structures have been determined from single-crystal X-ray diffraction data {LiCrII4(PO4)3: violet-blue, Pnma (no. 62), Z=4, a=6.175(1) Å, b=14.316(3) Å, c=10.277(2) Å, 100 parameters, R1=0.028, wR2=0.08, 2060 unique reflections with Fo>4σ(Fo); Li5CrII2CrIII(PO4)4: greyish-green, P1bar (no. 2), Z=1, a=4.9379(7) Å, b=7.917(2) Å, c=8.426(2) Å, α=109.98(2)°, β=90.71(1)°, γ=104.91(1)°, 131 parameters, R1=0.022, wR2=0.067, 1594 unique reflections with Fo>4σ(Fo)}. Li5CrII2CrIII(PO4)4 adopts an hitherto unknown structure type. The crystal structure of LiCrII4(PO4)3 is isotypic to that of NaCdII4(PO4)3 and related to that of the mineral silicocarnotite Ca5(PO4)2(SiO4). Significant disorder between Li+ and Cr2+ is observed for both crystal structures. The oxidation states assigned to chromium in these two phosphates are in agreement with UV/vis/NIR absorption spectra and magnetic susceptibility data recorded for both compounds. Instead of “LiCrIIPO4” mixtures of LiCrII4(PO4)3, Li5CrII2CrIII(PO4)4, Cr2O3, and CrP are observed at equilibrium. Instead of “Li2CrIIP2O7” four-phase mixtures consisting of Li9CrIII3(P2O7)3(PO4)2, Li3CrIII2(PO4)3, LiCrP2O7, and CrP were obtained.

E4bp4 regulates carboxylesterase 2 enzymes through repression of the nuclear receptor Rev-erbα in mice.

PubMed

Zhao, Mengjing; Zhang, Tianpeng; Yu, Fangjun; Guo, Lianxia; Wu, Baojian

2018-06-01

Carboxylesterases (CES) are a family of phase I enzymes that play an important role in xenobiotic clearance and lipid metabolism. Here, we investigate a potential role of E4 promoter-binding protein 4 (E4bp4) in regulation of Ces and CPT-11 (irinotecan, a first-line drug for treating colorectal cancer) pharmacokinetics in mice. Mouse hepatoma Hepa-1c1c7 cells were transfected with Rev-erbα expression plasmid or siRNA targeting E4bp4. The relative mRNA and protein levels of Ces enzymes in the cells or the livers of wild-type and E4bp4-deficient (E4bp4 -/- ) mice were determined by qPCR and Western blotting, respectively. Transcriptional regulation of Ces by E4bp4/Rev-erbα were investigated using luciferase reporter, mobility shift, and co-immunoprecipitation (Co-IP) assays. Pharmacokinetic studies were performed with wild-type and E4bp4 -/- mice after intraperitoneal injection of CPT-11. E4bp4 ablation down-regulated an array of hepatic Ces genes in mice. E4bp4 -/- mice also showed reduced Ces-mediated metabolism and elevated systemic exposure of CPT-11, a well-known Ces substrate. Consistently, E4bp4 knockdown reduced the expression of Ces genes (Ces2b, Ces2e and Ces2f) in Hepa-1c1c7 cells. Furthermore, Rev-erbα repressed the transcription of Ces2b, whereas E4bp4 antagonized this repressive action. Co-IP experiment confirmed a direct interaction between E4bp4 and Rev-erbα. Through a combination of promoter analysis and mobility shift assays, we demonstrated that Rev-erbα trans-repressed Ces (Ces2b) through its specific binding to the -767 to-754 bp promoter region. In conclusion, E4bp4 regulates Ces enzymes through inhibition of the transrepression activity of Rev-erbα, thereby impacting the metabolism and pharmacokinetics of Ces substrates. Copyright © 2018 Elsevier Inc. All rights reserved.