Composite Overwrapped Pressure Vessel (COPV) Stress Rupture Testing

NASA Technical Reports Server (NTRS)

Greene, Nathanael J.; Saulsberry, Regor L.; Leifeste, Mark R.; Yoder, Tommy B.; Keddy, Chris P.; Forth, Scott C.; Russell, Rick W.

2010-01-01

This paper reports stress rupture testing of Kevlar(TradeMark) composite overwrapped pressure vessels (COPVs) at NASA White Sands Test Facility. This 6-year test program was part of the larger effort to predict and extend the lifetime of flight vessels. Tests were performed to characterize control parameters for stress rupture testing, and vessel life was predicted by statistical modeling. One highly instrumented 102-cm (40-in.) diameter Kevlar(TradeMark) COPV was tested to failure (burst) as a single-point model verification. Significant data were generated that will enhance development of improved NDE methods and predictive modeling techniques, and thus better address stress rupture and other composite durability concerns that affect pressure vessel safety, reliability and mission assurance.

Pressure vessel burst test program - Initial program paper

NASA Technical Reports Server (NTRS)

Cain, Maurice R.; Sharp, Douglas E.; Coleman, Michael D.; Webb, Bobby L.

1990-01-01

The current status of a pressure vessel burst test program, aimed at the study of the blast waves and fragmentation characteristics of ruptured gas-filled pressure vessels, is reported. The program includes a series of test plans, each involving multiple bursts with burst pressures ranging to 7500 psig. The discussion covers the identification of concerns and hazards, application of the data generated, and a brief review of the current methods for assessing vessel safety and burst parameters. Attention is also given to pretest activities, including completed vessel and facility/instrumentation preparation and results of completed preliminary burst tests.

Composite Overwrapped Pressure Vessels: Database Extension Task 3.0 and Impact Damage Effects Control Task 8.0

NASA Technical Reports Server (NTRS)

Beeson, Harold D.; Davis, Dennis D.; Ross, William L., Sr.; Tapphorn, Ralph M.

2002-01-01

This document represents efforts accomplished at the NASA Johnson Space Center White Sands Test Facility (WSTF) in support of the Enhanced Technology for Composite Overwrapped Pressure Vessels (COPV) Program, a joint research and technology effort among the U.S. Air Force, NASA, and the Aerospace Corporation. WSTF performed testing for several facets of the program. Testing that contributed to the Task 3.0 COPV database extension objective included baseline structural strength, failure mode and safe-life, impact damage tolerance, sustained load/impact effect, and materials compatibility. WSTF was also responsible for establishing impact protection and control requirements under Task 8.0 of the program. This included developing a methodology for establishing an impact control plan. Seven test reports detail the work done at WSTF. As such, this document contributes to the database of information regarding COPV behavior that will ensure performance benefits and safety are maintained throughout vessel service life.

Composite Overwrapped Pressure Vessels (COPV): Developing Flight Rationale for the Space Shuttle Program

NASA Technical Reports Server (NTRS)

Kezirian, Michael T.

2010-01-01

Introducing composite vessels into the Space Shuttle Program represented a significant technical achievement. Each Orbiter vehicle contains 24 (nominally) Kevlar tanks for storage of pressurized helium (for propulsion) and nitrogen (for life support). The use of composite cylinders saved 752 pounds per Orbiter vehicle compared with all-metal tanks. The weight savings is significant considering each Shuttle flight can deliver 54,000 pounds of payload to the International Space Station. In the wake of the Columbia accident and the ensuing Return to Flight activities, the Space Shuttle Program, in 2005, re-examined COPV hardware certification. Incorporating COPV data that had been generated over the last 30 years and recognizing differences between initial Shuttle Program requirements and current operation, a new failure mode was identified, as composite stress rupture was deemed credible. The Orbiter Project undertook a comprehensive investigation to quantify and mitigate this risk. First, the engineering team considered and later deemed as unfeasible the option to replace existing all flight tanks. Second, operational improvements to flight procedures were instituted to reduce the flight risk and the danger to personnel. Third, an Orbiter reliability model was developed to quantify flight risk. Laser profilometry inspection of several flight COPVs identified deep (up to 20 mil) depressions on the tank interior. A comprehensive analysis was performed and it confirmed that these observed depressions were far less than the criterion which was established as necessary to lead to liner buckling. Existing fleet vessels were exonerated from this failure mechanism. Because full validation of the Orbiter Reliability Model was not possible given limited hardware resources, an Accelerated Stress Rupture Test of a flown flight vessel was performed to provide increased confidence. A Bayesian statistical approach was developed to evaluate possible test results with respect to the model credibility and thus flight rationale for continued operation of the Space Shuttle with existing flight hardware. A non-destructive evaluation (NDE) technique utilizing Raman Spectroscopy was developed to directly measure the overwrap residual stress state. Preliminary results provide optimistic results that patterns of fluctuation in fiber elastic strains over the outside vessel surface could be directly correlated with increased fiber stress ratios and thus reduced reliability.

Computer program developed for flowsheet calculations and process data reduction

NASA Technical Reports Server (NTRS)

Alfredson, P. G.; Anastasia, L. J.; Knudsen, I. E.; Koppel, L. B.; Vogel, G. J.

1969-01-01

Computer program PACER-65, is used for flowsheet calculations and easily adapted to process data reduction. Each unit, vessel, meter, and processing operation in the overall flowsheet is represented by a separate subroutine, which the program calls in the order required to complete an overall flowsheet calculation.

Commercial Earth Observation

NASA Technical Reports Server (NTRS)

1995-01-01

Through the Earth Observation Commercial Applications Program (EOCAP) at Stennis Space Center, Applied Analysis, Inc. developed a new tool for analyzing remotely sensed data. The Applied Analysis Spectral Analytical Process (AASAP) detects or classifies objects smaller than a pixel and removes the background. This significantly enhances the discrimination among surface features in imagery. ERDAS, Inc. offers the system as a modular addition to its ERDAS IMAGINE software package for remote sensing applications. EOCAP is a government/industry cooperative program designed to encourage commercial applications of remote sensing. Projects can run three years or more and funding is shared by NASA and the private sector participant. Through the Earth Observation Commercial Applications Program (EOCAP), Ocean and Coastal Environmental Sensing (OCENS) developed SeaStation for marine users. SeaStation is a low-cost, portable, shipboard satellite groundstation integrated with vessel catch and product monitoring software. Linked to the Global Positioning System, SeaStation provides real time relationships between vessel position and data such as sea surface temperature, weather conditions and ice edge location. This allows the user to increase fishing productivity and improve vessel safety. EOCAP is a government/industry cooperative program designed to encourage commercial applications of remote sensing. Projects can run three years or more and funding is shared by NASA and the private sector participant.

Properties important to mixing and simulant recommendations for WTP full-scale vessel testing

DOE Office of Scientific and Technical Information (OSTI.GOV)

Poirier, M. R.; Martino, C. J.

2015-12-01

Full Scale Vessel Testing (FSVT) is being planned by Bechtel National, Inc., to demonstrate the ability of the standard high solids vessel design (SHSVD) to meet mixing requirements over the range of fluid properties planned for processing in the Pretreatment Facility (PTF) of the Hanford Waste Treatment and Immobilization Plant (WTP). Testing will use simulated waste rather than actual Hanford waste. Therefore, the use of suitable simulants is critical to achieving the goals of the test program. WTP personnel requested the Savannah River National Laboratory (SRNL) to assist with development of simulants for use in FSVT. Among the tasks assignedmore » to SRNL was to develop a list of waste properties that are important to pulse-jet mixer (PJM) performance in WTP vessels with elevated concentrations of solids.« less

Comparison of Analysis Results Between 2D/1D Synthesis and RAPTOR-M3G in the Korea Standard Nuclear Plant (KSNP)

NASA Astrophysics Data System (ADS)

Joung Lim, Mi; Maeng, Young Jae; Fero, Arnold H.; Anderson, Stanwood L.

2016-02-01

The 2D/1D synthesis methodology has been used to calculate the fast neutron (E > 1.0 MeV) exposure to the beltline region of the reactor pressure vessel. This method uses the DORT 3.1 discrete ordinates code and the BUGLE-96 cross-section library based on ENDF/B-VI. RAPTOR-M3G (RApid Parallel Transport Of Radiation-Multiple 3D Geometries) which performs full 3D calculations was developed and is based on domain decomposition algorithms, where the spatial and angular domains are allocated and processed on multi-processor computer architecture. As compared to traditional single-processor applications, this approach reduces the computational load as well as the memory requirement per processor. Both methods are applied to surveillance test results for the Korea Standard Nuclear Plant (KSNP)-OPR (Optimized Power Reactor) 1000 MW. The objective of this paper is to compare the results of the KSNP surveillance program between 2D/1D synthesis and RAPTOR-M3G. Each operating KSNP has a reactor vessel surveillance program consisting of six surveillance capsules located between the core and the reactor vessel in the downcomer region near the reactor vessel wall. In addition to the In-Vessel surveillance program, an Ex-Vessel Neutron Dosimetry (EVND) program has been implemented. In order to estimate surveillance test results, cycle-specific forward transport calculations were performed by 2D/1D synthesis and by RAPTOR-M3G. The ratio between measured and calculated (M/C) reaction rates will be discussed. The current plan is to install an EVND system in all of the Korea PWRs including the new reactor type, APR (Advanced Power Reactor) 1400 MW. This work will play an important role in establishing a KSNP-specific database of surveillance test results and will employ RAPTOR-M3G for surveillance dosimetry location as well as positions in the KSNP reactor vessel.

ACHP | News | ACHP Issues Program Comment for Disposal of Navy vessels

Science.gov Websites

Search skip specific nav links Home arrow News arrow ACHP Issues Program Comment for Disposal of Navy vessels ACHP Issues Program Comment for Disposal of Navy vessels March 8, 2010 – The Advisory Council on Historic Preservation (ACHP) has issued a Program Comment, pursuant to 36 CFR 800.14(e), to the U.S. Navy

On impact testing of subsize Charpy V-notch type specimens

DOE Office of Scientific and Technical Information (OSTI.GOV)

Mikhail, A.S.; Nanstad, R.K.

1994-12-31

The potential for using subsize specimens to determine the actual properties of reactor pressure vessel steels is receiving increasing attention for improved vessel condition monitoring that could be beneficial for light-water reactor plant-life extension. This potential is made conditional upon, on the one hand, by the possibility of cutting samples of small volume from the internal surface of the pressure vessel for determination of actual properties of the operating pressure vessel. The plant-life extension will require supplemental surveillance data that cannot be provided by the existing surveillance programs. Testing of subsize specimens manufactured from broken halves of previously tested surveillancemore » Charpy V-notch (CVN) specimens offers an attractive means of extending existing surveillance programs. Using subsize CVN type specimens requires the establishment of a specimen geometry that is adequate to obtain a ductile-to-brittle transition curve similar to that obtained from full-size specimens. This requires the development of a correlation of transition temperature and upper-shelf toughness between subsize and full-size specimens. The present study was conducted under the Heavy-Section Steel Irradiation Program. Different published approaches to the use of subsize specimens were analyzed and five different geometries of subsize specimens were selected for testing and evaluation. The specimens were made from several types of pressure vessel steels with a wide range of yield strengths, transition temperatures, and upper-shelf energies (USEs). Effects of specimen dimensions, including depth, angle, and radius of notch have been studied. The correlation of transition temperature determined from different types of subsize specimens and the full-size specimen is presented. A new procedure for transforming data from subsize specimens was developed and is presented.« less

2007 Expeditionary Warfare Conference (12th)

DTIC Science & Technology

2007-10-25

Ships 10 Joint High Speed Vessel (JHSV) Today • Program Capability – High speed lift ship capable of transporting cargo and personnel across...develop technologies that will: – Improve the capability to transfer cargo between Sea Base platforms – Provide for high speed / heavy lift...state actors for legitimacy and influence over the relevant population” Joint High Speed Vessel In-Service Amphibs LCAC & Ship to Shore

Antibody-linked drug destroys tumor cells and tumor blood vessels in many types of cancer | Center for Cancer Research

Cancer.gov

A team led by Brad St. Croix, Ph.D., Senior Associate Scientist, Mouse Cancer Genetics Program, has developed an antibody-drug conjugate (ADC) that destroys both tumor cells and the blood vessels that nourish them. The drug significantly shrank breast tumors, colon tumors and several other types of cancer and prolonged survival. Learn more...  

Modernization of existing VVER-1000 surveillance programs

DOE Office of Scientific and Technical Information (OSTI.GOV)

Kochkin, V.; Erak, D.; Makhotin, D.

2011-07-01

According to generally accepted world practice, evaluation of the reactor pressure vessel (RPV) material behavior during operation is carried out using tests of surveillance specimens. The main objective of the surveillance program consists in insurance of safe RPV operation during the design lifetime and lifetime-extension period. At present, the approaches of pressure vessels residual life validation based on the test results of their surveillance specimens have been developed and introduced in Russia and are under consideration in other countries where vodo-vodyanoi energetichesky reactors- (VVER-) 1000 are in operation. In this case, it is necessary to ensure leading irradiation of surveillancemore » specimens (as compared to the pressure vessel wall) and to provide uniformly irradiated specimen groups for mechanical testing. Standard surveillance program of VVER-1000 has several significant shortcomings and does not meet these requirements. Taking into account program of lifetime extension of VVER-1000 operating in Russia, it is necessary to carry out upgrading of the VVER-1000 surveillance program. This paper studies the conditions of a surveillance specimen's irradiation and upgrading of existing sets to provide monitoring and prognosis of RPV material properties for extension of the reactor's lifetime up to 60 years or more. (authors)« less

Light water reactor lower head failure analysis

DOE Office of Scientific and Technical Information (OSTI.GOV)

Rempe, J.L.; Chavez, S.A.; Thinnes, G.L.

1993-10-01

This document presents the results from a US Nuclear Regulatory Commission-sponsored research program to investigate the mode and timing of vessel lower head failure. Major objectives of the analysis were to identify plausible failure mechanisms and to develop a method for determining which failure mode would occur first in different light water reactor designs and accident conditions. Failure mechanisms, such as tube ejection, tube rupture, global vessel failure, and localized vessel creep rupture, were studied. Newly developed models and existing models were applied to predict which failure mechanism would occur first in various severe accident scenarios. So that a broadermore » range of conditions could be considered simultaneously, calculations relied heavily on models with closed-form or simplified numerical solution techniques. Finite element techniques-were employed for analytical model verification and examining more detailed phenomena. High-temperature creep and tensile data were obtained for predicting vessel and penetration structural response.« less

50 CFR 648.262 - Effort-control program for red crab limited access vessels.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 50 Wildlife and Fisheries 8 2010-10-01 2010-10-01 false Effort-control program for red crab... UNITED STATES Management Measures for the Atlantic Deep-Sea Red Crab Fishery § 648.262 Effort-control program for red crab limited access vessels. (a) General. A vessel issued a limited access red crab permit...

Selection of specimen types for irradiation surveillance programs

DOE Office of Scientific and Technical Information (OSTI.GOV)

Varga, T.; Njo, D.H.

1981-10-01

Recent trends in coping with embrittlement problems in reactor pressure vessels (RPVs) show two main directions of development: (1) improvement of the vessel materials and (2) limitations of fluence over the design life of the RPV. For several reasons, however, adequate irradiation surveillance programs are still considered to be necessary in the future, despite possible improvements resulting from such research activities. Since the introduction of linear elastic fracture mechanics (LEFM) and elastic-plastic fracture mechanics, (EPFM), irradiation surveillance programs show a trend towards direct measurement of fracture toughness, in addition to relying on the conventional nil-ductility transition temperature (NDTT) shift asmore » a relative measure of embrittlement. Some basic considerations concerning the selection of specimen types for irradiation surveillance programs and some technical aspects of currently used speciment types are discussed.« less

50 CFR 253.11 - Guarantee policy.

Code of Federal Regulations, 2010 CFR

2010-10-01

..., except: (1) Vessel construction. The Program will not finance this project cost. The Program will only refinance this project cost for an existing vessel whose previous construction cost has already been financed (or otherwise paid). Refinancing this project cost for a vessel that already exists is not...

A consonant construction of the hyaloid and retinal vascular systems by the angiogenic process.

PubMed

Gergely, K; Gerinec, A

2011-01-01

There has been much debate as to whether the retinal vasculature forms by angiogenesis or vasculogenesis, thus angiogenesis is now accepted. We suppose that signals necessary for proper localization and development of the hyaloid and retinal vascular systems are already in place prior to the time at which these systems are developed. The remarkable conservation of vascular patterning suggests that specific genetic programs coordinate its formation. Evidence for a genetic program comes particularly from the characterization of gene-targeted mice and mutational analysis in zebrafish, but the exact genetic pathways remain poorly defined. Considering all the things from the aspect of angiogenesis significant differences exist between the mentioned vascular systems only in their lifetime (a) and location (b): (a) The hyaloid vasculature is a complex of transient intraocular vessels, while the retinal vessels are adapted for the whole life. (b) The hyaloid system fills the interior of the optic cup and this way "occupies" three-dimensional space while the distribution of the retinal vessels is relatively planar (two-dimensional) in the retina. We assume that retinal vessels are "built" in the same manner as the hyaloid vasculature and the outcomes at the embryological, histological, cellular and molecular levels confirm it. We show a consonant construction of both systems. The human organism does not have any rational reason to build up one system (i.e. the hyaloid vasculature) by angiogenesis and practically the same system (i.e. the retinal vessels) by another, de novo process, in the eye. It would be a waste of energy and various essential molecules. Thus, it seems that the retinal vascular system is an advanced copy of the hyaloid vessels (Tab. 1, Ref. 143).

How to quantify conduits in wood?

PubMed

Scholz, Alexander; Klepsch, Matthias; Karimi, Zohreh; Jansen, Steven

2013-01-01

Vessels and tracheids represent the most important xylem cells with respect to long distance water transport in plants. Wood anatomical studies frequently provide several quantitative details of these cells, such as vessel diameter, vessel density, vessel element length, and tracheid length, while important information on the three dimensional structure of the hydraulic network is not considered. This paper aims to provide an overview of various techniques, although there is no standard protocol to quantify conduits due to high anatomical variation and a wide range of techniques available. Despite recent progress in image analysis programs and automated methods for measuring cell dimensions, density, and spatial distribution, various characters remain time-consuming and tedious. Quantification of vessels and tracheids is not only important to better understand functional adaptations of tracheary elements to environment parameters, but will also be essential for linking wood anatomy with other fields such as wood development, xylem physiology, palaeobotany, and dendrochronology.

46 CFR 8.530 - Plan development and approval.

Code of Federal Regulations, 2011 CFR

2011-10-01

... 46 Shipping 1 2011-10-01 2011-10-01 false Plan development and approval. 8.530 Section 8.530 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY PROCEDURES APPLICABLE TO THE PUBLIC VESSEL INSPECTION ALTERNATIVES Streamlined Inspection Program § 8.530 Plan development and approval. The Company SIP Agent will...

46 CFR 8.530 - Plan development and approval.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 46 Shipping 1 2010-10-01 2010-10-01 false Plan development and approval. 8.530 Section 8.530 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY PROCEDURES APPLICABLE TO THE PUBLIC VESSEL INSPECTION ALTERNATIVES Streamlined Inspection Program § 8.530 Plan development and approval. The Company SIP Agent will...

Nitramine smokeless propellant research

NASA Technical Reports Server (NTRS)

1977-01-01

A transient ballistics and combustion model was derived to represent the closed vessel experiment that is widely used to characterize propellants. The model incorporates the nitramine combustion mechanisms. A computer program was developed to solve the time dependent equations, and was applied to explain aspects of closed vessel behavior. It is found that the rate of pressurization in the closed vessel is insufficient at pressures of interest to augment the burning rate by time dependent processes. Series of T-burner experiments were performed to compare the combustion instability characteristics of nitramine (HMX) containing propellants and ammonium perchlorate (AP) propellants. It is found that the inclusion of HMX consistently renders the propellant more stable.

DOD Residential Proton Exchange Membrane (PEM) Fuel Cell Demonstration Program. Volume 1. Summary of the Fiscal Year 2001 Program

DTIC Science & Technology

2004-02-01

Potential new stan- dard ASME Boiler and Pressure Vessel Code, Section VIII ( BPVC -VIII), Division 1 Rules for Construction of Pressure Vessels...Published and avail- able for sale. ASME BPVC -VIII Division 2 Rules for Construction of Pressure Vessels, Division 2, Gerry Eisenberg, ASME ...Vessels, Division 3, Alternate ASME BPVC -VIII Division 3 Gerry Eisenberg, ASME Published and avail- able for sale. Rules High

Investigation of Fuel Oil/Lube Oil Spray Fires On Board Vessels. Volume 3.

DTIC Science & Technology

1998-11-01

U.S. Coast Guard Research and Development Center 1082 Shennecossett Road, Groton, CT 06340-6096 Report No. CG-D-01-99, III Investigation of Fuel ...refinery). Developed the technical and mathematical specifications for BRAVO™2.0, a state-of-the-art Windows program for performing event tree and fault...tree analyses. Also managed the development of and prepared the technical specifications for QRA ROOTS™, a Windows program for storing, searching K-4

Nitramine smokeless propellant research

NASA Technical Reports Server (NTRS)

Cohen, N. S.; Strand, L. P.

1977-01-01

A transient ballistics and combustion model is derived to represent the closed vessel experiment that is widely used to characterize propellants. A computer program is developed to solve the time-dependent equations, and is applied to explain aspects of closed vessel behavior. In the case of nitramine propellants the cratering of the burning surface associated with combustion above break-point pressures augments the effective burning rate as deduced from the closed vessel experiment. Low pressure combustion is significantly affected by the ignition process and, in the case of nitramine propellants, by the developing and changing surface structure. Thus, burning rates deduced from the closed vessel experiment may or may not agree with those measured in the equilibrium strand burner. Series of T burner experiments are performed to compare the combustion instability characteristics of nitramine (HMX) containing propellants and ammonium perchlorate (AP)propellants. Although ash produced by more fuel rich propellants could have provided mechanical suppression, results from clean-burning propellants permit the conclusion that HMX reduces the acoustic driving.

Developing Soft Power Using Afloat Medical Capability

DTIC Science & Technology

2009-03-02

the National Security Strategy. Depending on its program employment , it has the capability to effectively combine the other elements of national power...Strategy through the employment of combatant commanders’ Theater Security Cooperation (TSC) Program in their area of responsibility. The TSC program is...In the final phases of Pacific campaign during World War II, tactical doctrine for employment of Navy hospital vessels changed, allowing them to

The successful evolution of a voluntary vessel safety program in the USA.

PubMed

Hughes, Leslie

2006-01-01

The North Pacific Fishing Vessel Owners' Association (NPFVOA) is a non-profit association dedicated to safety education and training for commercial fishermen and other mariners. Funding is provided primarily through member contributions and also through tuition fees and sales of materials. Members are primarily fishing vessel owners and fishing-related companies, from small salmon boats with single operators to large processing ships with crews of 150 or more. The Association also works together with insurance underwriters and brokers, maritime attorneys and fishing industry support businesses. It works closely with the United States Coast Guard, the Occupational Safety and Health Administration (OSHA) of the United States Department of Labor, the National Institute for Occupational Safety and Health (NIOSH), and many state agencies. There are three primary components of the NPFVOA Vessel Safety Program--a comprehensive safety manual, a series of safety and survival at sea videotapes, and a crew training program. The vessel safety manual includes 300 pages of text and illustrations covering subjects ranging from vessel familiarity for deckhands to stability for the owner and skipper. It is based on the experience of those who have fished the Bering Sea and the North Pacific. The manual calls for vessel owners and skippers to adopt safety practices specific to the vessel's characteristics and service, the waters fished, the season fished and the experience of the crew. The safety and survival videotape series is designed to complement hands-on training classes. The crew training program uses hands-on practice to dramatize and enliven the information presented in the manual and on the videotapes. Courses are designed to be portable and conducted in numerous ports and states. The NPFVOA also publishes a quarterly newsletter covering its safety program, other relevant safety information and reports of lessons learned from serious fishing vessel accidents.

Composite Overwrapped Pressure Vessels (COPV): Flight Rationale for the Space Shuttle Program

NASA Technical Reports Server (NTRS)

Kezirian, Michael T.; Johnson, Kevin L.; Phoenix, Stuart L.

2011-01-01

Each Orbiter Vehicle (Space Shuttle Program) contains up to 24 Kevlar49/Epoxy Composite Overwrapped Pressure Vessels (COPV) for storage of pressurized gases. In the wake of the Columbia accident and the ensuing Return To Flight (RTF) activities, Orbiter engineers reexamined COPV flight certification. The original COPV design calculations were updated to include recently declassified Kevlar COPV test data from Lawrence Livermore National Laboratory (LLNL) and to incorporate changes in how the Space Shuttle was operated as opposed to orinigially envisioned. 2005 estimates for the probability of a catastrophic failure over the life of the program (from STS-1 through STS-107) were one-in-five. To address this unacceptable risk, the Orbiter Project Office (OPO) initiated a comprehensive investigation to understand and mitigate this risk. First, the team considered and eventually deemed unfeasible procuring and replacing all existing flight COPVs. OPO replaced the two vessels with the highest risk with existing flight spare units. Second, OPO instituted operational improvements in ground procedures to signficiantly reduce risk, without adversely affecting Shuttle capability. Third, OPO developed a comprehensive model to quantify the likelihood of occurrance. A fully-instrumented burst test (recording a lower burst pressure than expected) on a flight-certified vessel provided critical understanding of the behavior of Orbiter COPVs. A more accurate model was based on a newly-compiled comprehensive database of Kevlar data from LLNL and elsewhere. Considering hardware changes, operational improvements and reliability model refinements, the mean reliability was determined to be 0.998 for the remainder of the Shuttle Program (from 2007, for STS- 118 thru STS-135). Since limited hardware resources precluded full model validation through multiple tests, additional model confidence was sought through the first-ever Accelerated Stress Rupture Test (ASRT) of a flown flight article. A Bayesian statistical approach was developed to interpret possible test results. Since the lifetime observed in the ASRT exceeded initial estimates by one to two orders of magnitude, the Space Shuttle Program deemed there was significant conservatism in the model and accepted continued operation with existing flight hardware. Given the variability in tank-to-tank original prooftest response, a non-destructive evaluation (NDE) technique utilizing Raman Spectroscopy was developed to directly measure COPV residual stress state. Preliminary results showed that patterns of low fiber elastic strains over the outside vessel surface, together with measured permanent volume growth during proof, could be directly correlated to increased fiber stress ratios on the inside fibers adjacent to the liner, and thus reduced reliability.

Heavy-section steel technology and irradiation programs-retrospective and prospective views

DOE Office of Scientific and Technical Information (OSTI.GOV)

Nanstad, Randy K; Bass, Bennett Richard; Rosseel, Thomas M

In 1965, the Atomic Energy Commission (AEC), at the advice of the Advisory Committee on Reactor Safeguards (ACRS), initiated the process that resulted in the establishment of the Heavy Section Steel Technology (HSST) Program at Oak Ridge National Laboratory (ORNL). Dr. Spencer H. Bush of Battelle Northwest Laboratory, the man being honored by this symposium, representing the ACRS, was one of the Staff Advisors for the program and helped to guide its technical direction. In 1989, the Heavy-Section Steel Irradiation (HSSI) Program, formerly the HSST task on irradiation effects, was formed as a separate program, and this year the HSST/HSSImore » Programs, sponsored by the U.S. Nuclear Regulatory Commission (USNRC), celebrate 40 years of continuous research oriented toward the safety of light-water nuclear reactor pressure vessels. This paper presents a summary of results from those programs with a view to future activities. The HSST Program was established in 1967 and initially included extensive investigations of heavy-section low-alloy steel plates, forgings, and welds, including metallurgical studies, mechanical properties, fracture toughness (quasi-static and dynamic), fatigue crack-growth, and crack arrest toughness. Also included were irradiation effects studies, thermal shock analyses, testing of thick-section tensile and fracture specimens, and non-destructive testing. In the subsequent decades, the HSST Program conducted extensive large-scale experiments with intermediate-size vessels (with varying size flaws) pressurized to failure, similar experiments under conditions of thermal shock and even pressurized thermal shock (PTS), wide-plate crack arrest tests, and biaxial tests with cruciform-shaped specimens. Extensive analytical and numerical studies accompanied these experiments, including the development of computer codes such as the recent Fracture Analysis of Vessels Oak Ridge (FAVOR) code currently being used for PTS evaluations. In the absence of radiation damage to the RPV, fracture of the vessel is improbable. However, exposure to high energy neutrons can result in embrittlement of radiation-sensitive RPV materials. The HSSI Program has conducted a series of experiments to assess the effects of neutron irradiation on RPV material behavior, especially fracture toughness. These studies have included RPV plates and welds, varying chemical compositions, and fracture toughness specimens up to 4 in. thickness. The results of these investigations, in conjunction with results from commercial reactor surveillance programs, are used to develop a methodology for the prediction of radiation effects on RPV materials. Results from the HSST and HSSI Program are used by the USNRC in the evaluation of RPV integrity and regulation of overall nuclear plant safety.« less

50 CFR 648.95 - Offshore Fishery Program in the SFMA.

Code of Federal Regulations, 2010 CFR

2010-10-01

... DAS. (2) When not fishing on a monkfish DAS, a Category F vessel may fish under the regulations... fishing on a NE multispecies DAS in the NFMA, a Category F vessel that also possesses a NE multispecies... monkfish DAS program during that fishing year. If such a request is not received within 45 days, the vessel...

50 CFR 622.20 - Individual fishing quota (IFQ) program for Gulf groupers and tilefishes.

Code of Federal Regulations, 2012 CFR

2012-10-01

... actual ex-vessel price of groupers and tilefishes landed and sold; and information necessary to identify... groupers and tilefishes. The fee cannot exceed 3 percent of the ex-vessel value of Gulf groupers and... actual ex-vessel price of Gulf groupers and tilefishes landed per trip under the IFQ program, as...

50 CFR 622.16 - Gulf red snapper individual fishing quota (IFQ) program.

Code of Federal Regulations, 2012 CFR

2012-10-01

.... Factors considered in the review include the catch subject to the IFQ cost recovery, projected ex-vessel..., and location of transaction; weight and actual ex-vessel price of red snapper landed and sold; and... snapper IFQ program. The fee cannot exceed 3 percent of the ex-vessel value of Gulf red snapper landed...

Advanced nickel-hydrogen spacecraft battery development

NASA Technical Reports Server (NTRS)

Coates, Dwaine K.; Fox, Chris L.; Standlee, D. J.; Grindstaff, B. K.

1994-01-01

Eagle-Picher currently has several advanced nickel-hydrogen (NiH2) cell component and battery designs under development including common pressure vessel (CPV), single pressure vessel (SPV), and dependent pressure vessel (DPV) designs. A CPV NiH2 battery, utilizing low-cost 64 mm (2.5 in.) cell diameter technology, has been designed and built for multiple smallsat programs, including the TUBSAT B spacecraft which is currently scheduled (24 Nov. 93) for launch aboard a Russian Proton rocket. An advanced 90 mm (3.5 in.) NiH2 cell design is currently being manufactured for the Space Station Freedom program. Prototype 254 mm (10 in.) diameter SPV batteries are currently under construction and initial boilerplate testing has shown excellent results. NiH2 cycle life testing is being continued at Eagle-Picher and IPV cells have currently completed more than 89,000 accelerated LEO cycles at 15% DOD, 49,000 real-time LEO cycles at 30 percent DOD, 37,800 cycles under a real-time LEO profile, 30 eclipse seasons in accelerated GEO, and 6 eclipse seasons in real-time GEO testing at 75 percent DOD maximum. Nickel-metal hydride battery development is continuing for both aerospace and electric vehicle applications. Eagle-Picher has also developed an extensive range of battery evaluation, test, and analysis (BETA) measurement and control equipment and software, based on Hewlett-Packard computerized data acquisition/control hardware.

Expanding the Telepresence Paradigm to the UNOLS Fleet

NASA Astrophysics Data System (ADS)

Coleman, D.; Scowcroft, G.

2014-12-01

The Inner Space Center (ISC) at the University of Rhode Island Graduate School of Oceanography (URI-GSO) has been at the forefront of developing the tools, techniques, and protocols for telepresence-enabled ocean science exploration and education programs. Working primarily with the Ocean Exploration Trust's E/V Nautilus and the NOAA Ship Okeanos Explorer, the ISC facility and staff have supported dozens of research cruises with significant shore-based support, while delivering related educational programming across the globe. Through a partnership with the University National Oceanographic Laboratory System (UNOLS), the ISC is broadening its reach and capabilities to serve vessels in the U.S. academic research fleet, managed by UNOLS. The ISC has developed and used a portable shipboard "mobile telepresence unit" (MTU) on several UNOLS ships to support projects led by ocean scientists that employed the telepresence paradigm as part of their research and outreach programs. Utilizing the ISC facilities provides opportunities for effective, successful broader impact activities and shore-based remote science connectivity. With new UNOLS ships coming online, including the R/V Sikuliaq, the R/V Neil Armstrong, and the R/V Sally Ride, in addition to future Regional Class Research Vessels (RCRVs), telepresence capability has become a technical requirement for a variety of reasons. Older vessels are being retrofit with this forward-looking technology, and URI's research vessel, the R/V Endeavor, has been recently configured with technology to support telepresence operations. This presentation will provide an overview of the future of telepresence technology, its use in ocean science research and education, and advantages for using this capability to support broader impact activities. In addition, ISC successes, challenges, and lessons learned in employing telepresence technologies and methodologies onboard the academic research fleet will be discussed.

50 CFR 622.21 - Individual fishing quota (IFQ) program for Gulf red snapper.

Code of Federal Regulations, 2013 CFR

2013-10-01

... transaction; weight and actual ex-vessel price of red snapper landed and sold; and information necessary to... exceed 3 percent of the ex-vessel value of Gulf red snapper landed under the IFQ program as described in... (LASAF). Initially, the fee will be 3 percent of the actual ex-vessel price of Gulf red snapper landed...

50 CFR 622.21 - Individual fishing quota (IFQ) program for Gulf red snapper.

Code of Federal Regulations, 2014 CFR

2014-10-01

... includes, but is not limited to, date, time, and location of transaction; weight and actual ex-vessel price... the ex-vessel value of Gulf red snapper landed under the IFQ program as described in the Magnuson...). Initially, the fee will be 3 percent of the actual ex-vessel price of Gulf red snapper landed per trip under...

DEVELOPMENT OF WELDED SEAL FOR S3G REACTOR VESSEL

DOE Office of Scientific and Technical Information (OSTI.GOV)

Rogers, J.W.

1958-01-01

The development program consisted of preliminary design, welding accessibility and feasibility, pressure and displacement cycling, theoretical analysis and life computation, photoelastic analysis, and comparison of PWR straight sample cycling. Design ''C'' of the three primary designs considered proved more satisfactory from a fatigue life standpoint. (W.D. M.)

Seaway Information System Management and Control Requirements

DOT National Transportation Integrated Search

1973-10-01

This report examines in detail the control and information system requirements of the St. Lawrence Seaway development program in terms of the needs of the vessel traffic controllers and the management users. Structural control models of Seaway operat...

How does non-formal marine education affect student attitude and knowledge? A case study using SCDNR's Discovery program

NASA Astrophysics Data System (ADS)

McGovern, Mary Francis

Non-formal environmental education provides students the opportunity to learn in ways that would not be possible in a traditional classroom setting. Outdoor learning allows students to make connections to their environment and helps to foster an appreciation for nature. This type of education can be interdisciplinary---students not only develop skills in science, but also in mathematics, social studies, technology, and critical thinking. This case study focuses on a non-formal marine education program, the South Carolina Department of Natural Resources' (SCDNR) Discovery vessel based program. The Discovery curriculum was evaluated to determine impact on student knowledge about and attitude toward the estuary. Students from two South Carolina coastal counties who attended the boat program during fall 2014 were asked to complete a brief survey before, immediately after, and two weeks following the program. The results of this study indicate that both student knowledge about and attitude significantly improved after completion of the Discovery vessel based program. Knowledge and attitude scores demonstrated a positive correlation.

Spin Forming Aluminum Crew Module (CM) Metallic Aft Pressure Vessel Bulkhead (APVBH) - Phase II

NASA Technical Reports Server (NTRS)

Hoffman, Eric K.; Domack, Marcia S.; Torres, Pablo D.; McGill, Preston B.; Tayon, Wesley A.; Bennett, Jay E.; Murphy, Joseph T.

2015-01-01

The principal focus of this project was to assist the Multi-Purpose Crew Vehicle (MPCV) Program in developing a spin forming fabrication process for manufacture of the Orion crew module (CM) aft pressure vessel bulkhead. The spin forming process will enable a single piece aluminum (Al) alloy 2219 aft bulkhead resulting in the elimination of the current multiple piece welded construction, simplify CM fabrication, and lead to an enhanced design. Phase I (NASA TM-2014-218163 (1)) of this assessment explored spin forming the single-piece CM forward pressure vessel bulkhead. The Orion MPCV Program and Lockheed Martin (LM) recently made two critical decisions relative to the NESC Phase I work scope: (1) LM selected the spin forming process to manufacture a single-piece aft bulkhead for the Orion CM, and (2) the aft bulkhead will be manufactured from Al 2219. Based on the Program's new emphasis related to the spin forming process, the NESC was asked to conduct a Phase II assessment to assist in the LM manufacture of the aft bulkhead and to conduct a feasibility study into spin forming the Orion CM cone. This activity was approved on June 19, 2013. Dr. Robert Piascik, NASA Technical Fellow for Materials at the Langley Research Center (LaRC), was selected to lead this assessment. The project plan was approved by the NASA Engineering and Safety Center (NESC) Review Board (NRB) on July 18, 2013. The primary stakeholders for this assessment were the NASA and LM MPCV Program offices. Additional benefactors are commercial launch providers developing CM concepts.

Spin Forming Aluminum Crew Module (CM) Metallic Aft Pressure Vessel Bulkhead (APVBH) - Phase II

NASA Technical Reports Server (NTRS)

Hoffman, Eric K.; Domack, Marcia S.; Torres, Pablo D.; McGill, Preston B.; Tayon, Wesley A.; Bennett, Jay E.; Murphy, Joseph T.

2015-01-01

The principal focus of this project was to assist the Multi-Purpose Crew Vehicle (MPCV) program in developing a spin forming fabrication process for manufacture of the Orion crew module (CM) aft pressure vessel bulkhead. The spin forming process will enable a single piece aluminum (Al) alloy 2219 aft bulkhead resulting in the elimination of the current multiple piece welded construction, simplify CM fabrication, and lead to an enhanced design. Phase I (NASA TM-2014-218163, (1)) of this assessment explored spin forming the single-piece CM forward pressure vessel bulkhead. The MPCV Program and Lockheed Martin (LM) recently made two critical decisions relative to the NESC Phase I work scope: (1) LM selected the spin forming process to manufacture a singlepiece aft bulkhead for the Orion CM, and (2) the aft bulkhead will be manufactured from Al 2219. Based on the Program's new emphasis related to the spin forming process, the NESC was asked to conduct a Phase II assessment to assist in the LM manufacture of the aft bulkhead and to conduct a feasibility study into spin forming the Orion CM cone. This activity was approved on June 19, 2013. Dr. Robert Piascik, NASA Technical Fellow for Materials at the Langley Research Center (LaRC), was selected to lead this assessment. The project plan was approved by the NASA Engineering and Safety Center (NESC) Review Board (NRB) on July 18, 2013. The primary stakeholders for this assessment are the NASA and LM MPCV Program offices. Additional benefactors are commercial launch providers developing CM concepts.

46 CFR 176.630 - The Alternative Hull Examination (AHE) Program application.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 46 Shipping 7 2010-10-01 2010-10-01 false The Alternative Hull Examination (AHE) Program... PASSENGER VESSELS (UNDER 100 GROSS TONS) INSPECTION AND CERTIFICATION Hull and Tailshaft Examinations § 176.630 The Alternative Hull Examination (AHE) Program application. If your vessel meets the eligibility...

Lessons Learned From Developing Reactor Pressure Vessel Steel Embrittlement Database

DOE Office of Scientific and Technical Information (OSTI.GOV)

Wang, Jy-An John

Materials behaviors caused by neutron irradiation under fission and/or fusion environments can be little understood without practical examination. Easily accessible material information system with large material database using effective computers is necessary for design of nuclear materials and analyses or simulations of the phenomena. The developed Embrittlement Data Base (EDB) at ORNL is this comprehensive collection of data. EDB database contains power reactor pressure vessel surveillance data, the material test reactor data, foreign reactor data (through bilateral agreements authorized by NRC), and the fracture toughness data. The lessons learned from building EDB program and the associated database management activity regardingmore » Material Database Design Methodology, Architecture and the Embedded QA Protocol are described in this report. The development of IAEA International Database on Reactor Pressure Vessel Materials (IDRPVM) and the comparison of EDB database and IAEA IDRPVM database are provided in the report. The recommended database QA protocol and database infrastructure are also stated in the report.« less

Collapsible Cryogenic Storage Vessel Project

NASA Technical Reports Server (NTRS)

Fleming, David C.

2002-01-01

Collapsible cryogenic storage vessels may be useful for future space exploration missions by providing long-term storage capability using a lightweight system that can be compactly packaged for launch. Previous development efforts have identified an 'inflatable' concept as most promising. In the inflatable tank concept, the cryogen is contained within a flexible pressure wall comprised of a flexible bladder to contain the cryogen and a fabric reinforcement layer for structural strength. A flexible, high-performance insulation jacket surrounds the vessel. The weight of the tank and the cryogen is supported by rigid support structures. This design concept is developed through physical testing of a scaled pressure wall, and through development of tests for a flexible Layered Composite Insulation (LCI) insulation jacket. A demonstration pressure wall is fabricated using Spectra fabric for reinforcement, and burst tested under noncryogenic conditions. An insulation test specimens is prepared to demonstrate the effectiveness of the insulation when subject to folding effects, and to examine the effect of compression of the insulation under compressive loading to simulate the pressure effect in a nonrigid insulation blanket under the action atmospheric pressure, such as would be seen in application on the surface of Mars. Although pressure testing did not meet the design goals, the concept shows promise for the design. The testing program provides direction for future development of the collapsible cryogenic vessel concept.

Soundwatch: Eighteen years of monitoring whale watch vessel activities in the Salish Sea.

PubMed

Seely, Elizabeth; Osborne, Richard W; Koski, Kari; Larson, Shawn

2017-01-01

The Soundwatch Boater Education Program is a vessel monitoring and public education outreach program. Soundwatch has been run by The Whale Museum (TWM) during the whale watch season (May through September) in the Haro Strait Region of the Central Salish Sea since 1993. Data collection has been in a consistent manner since 1998 and is presented here. The program compiles data on vessel types and vessel interactions with marine mammals with a focus on the Southern Resident killer whale (SRKW), Orcinas orca, which was listed as endangered under the U.S. Endangered Species Act (ESA) in 2005. The primary goal of the Soundwatch program is to reduce vessel disturbance to SRKWs and other marine wildlife through the education of boaters on regional, local and federal guidelines and regulations and the systematic monitoring of vessel activities around cetaceans. Since 1998, the number of active commercial whale watching vessels has increased over time; ranging from a low of 63 in 1999, to a high of 96 in 2015. In addition, the number of vessel incidents or violation of regulations and guidelines has also increased; ranging from a low of 398 in 1998 to a high of 2621 in 2012. Soundwatch collected data on 23 incident types, some remaining the same over the 18-year data set and some changing over time. The most common incidents over the 18 years were "Within 880 m of Lime Kiln" and "Crossing the path of whales". The numbers of people kayaking near whales also significantly increased since 2004 with the incident "kayaks spread out" with a significantly increasing trend making it difficult for whales to avoid vessels. These results suggest a need for further outreach for effective education and enforcement of whale watching guidelines and regulations in the Central Salish Sea.

Manual for the Training of United States Fisheries Observer Corps Atlantic Region. Marine Bulletin 33.

ERIC Educational Resources Information Center

Merdinyan, Mark E.; Mortimer, Christine D.

This manual has been produced for use in a four-week training program developed by University of Rhode Island fisheries educators for the training of United States citizens in the duties and responsibilities of observers placed on foreign fishing vessels operating in the Fisheries Conservation Zone in the Atlantic Region. The program combines…

Designing of a Fleet-Leader Program for Carbon Composite Overwrapped Pressure Vessels

NASA Technical Reports Server (NTRS)

Murthy, Pappu L.N.; Phoenix, S. Leigh

2009-01-01

Composite Overwrapped Pressure Vessels (COPVs) are often used for storing pressurant gases on board spacecraft when mass saving is a prime requirement. Substantial weight savings can be achieved compared to all metallic pressure vessels. For example, on the space shuttle, replacement of all metallic pressure vessels with Kevlar COPVs resulted in a weight savings of about 30 percent. Mass critical space applications such as the Ares and Orion vehicles are currently being planned to use as many COPVs as possible in place of all-metallic pressure vessels to minimize the overall mass of the vehicle. Due to the fact that overwraps are subjected to sustained loads during long periods of a mission, stress rupture failure is a major concern. It is, therefore, important to ascertain the reliability of these vessels by analysis, since it is practically impossible to show by experimental testing the reliability of flight quality vessels. Also, it is a common practice to set aside flight quality vessels as "fleet leaders" in a test program where these vessels are subjected to slightly accelerated operating conditions so that they lead the actual flight vessels both in time and load. The intention of fleet leaders is to provide advanced warning if there is a serious design flaw in the vessels so that a major disaster in the flight vessels can be averted with advance warning. On the other hand, the accelerating conditions must be not so severe as to be prone to false alarms. The primary focus of the present paper is to provide an analytical basis for designing a viable fleet leader program for carbon COPVs. The analysis is based on a stress rupture behavior model incorporating Weibull statistics and power-law sensitivity of life to fiber stress level.

77 FR 57572 - Notice of Arrival on the Outer Continental Shelf

Federal Register 2010, 2011, 2012, 2013, 2014

2012-09-18

... program currently requires NOA information for those vessels, facilities, and Mobile Offshore Drilling... Lendvay, Commercial Vessel Compliance, Foreign and Offshore Vessel Compliance Division (CG-CVC-2), U.S... 2254), which required NOA information for those vessels, facilities and Mobile Drilling Units (MODUs...

Pressure Safety Program Implementation at ORNL

DOE Office of Scientific and Technical Information (OSTI.GOV)

Lower, Mark; Etheridge, Tom; Oland, C. Barry

2013-01-01

The Oak Ridge National Laboratory (ORNL) is a US Department of Energy (DOE) facility that is managed by UT-Battelle, LLC. In February 2006, DOE promulgated worker safety and health regulations to govern contractor activities at DOE sites. These regulations, which are provided in 10 CFR 851, Worker Safety and Health Program, establish requirements for worker safety and health program that reduce or prevent occupational injuries, illnesses, and accidental losses by providing DOE contractors and their workers with safe and healthful workplaces at DOE sites. The regulations state that contractors must achieve compliance no later than May 25, 2007. According tomore » 10 CFR 851, Subpart C, Specific Program Requirements, contractors must have a structured approach to their worker safety and health programs that at a minimum includes provisions for pressure safety. In implementing the structured approach for pressure safety, contractors must establish safety policies and procedures to ensure that pressure systems are designed, fabricated, tested, inspected, maintained, repaired, and operated by trained, qualified personnel in accordance with applicable sound engineering principles. In addition, contractors must ensure that all pressure vessels, boilers, air receivers, and supporting piping systems conform to (1) applicable American Society of Mechanical Engineers (ASME) Boiler and Pressure Vessel Code (2004) Sections I through XII, including applicable code cases; (2) applicable ASME B31 piping codes; and (3) the strictest applicable state and local codes. When national consensus codes are not applicable because of pressure range, vessel geometry, use of special materials, etc., contractors must implement measures to provide equivalent protection and ensure a level of safety greater than or equal to the level of protection afforded by the ASME or applicable state or local codes. This report documents the work performed to address legacy pressure vessel deficiencies and comply with pressure safety requirements in 10 CFR 851. It also describes actions taken to develop and implement ORNL’s Pressure Safety Program.« less

Development of a virtual reality training system for endoscope-assisted submandibular gland removal.

PubMed

Miki, Takehiro; Iwai, Toshinori; Kotani, Kazunori; Dang, Jianwu; Sawada, Hideyuki; Miyake, Minoru

2016-11-01

Endoscope-assisted surgery has widely been adopted as a basic surgical procedure, with various training systems using virtual reality developed for this procedure. In the present study, a basic training system comprising virtual reality for the removal of submandibular glands under endoscope assistance was developed. The efficacy of the training system was verified in novice oral surgeons. A virtual reality training system was developed using existing haptic devices. Virtual reality models were constructed from computed tomography data to ensure anatomical accuracy. Novice oral surgeons were trained using the developed virtual reality training system. The developed virtual reality training system included models of the submandibular gland and surrounding connective tissues and blood vessels entering the submandibular gland. Cutting or abrasion of the connective tissue and manipulations, such as elevation of blood vessels, were reproduced by the virtual reality system. A training program using the developed system was devised. Novice oral surgeons were trained in accordance with the devised training program. Our virtual reality training system for endoscope-assisted removal of the submandibular gland is effective in the training of novice oral surgeons in endoscope-assisted surgery. Copyright © 2016 The Author(s). Published by Elsevier Ltd.. All rights reserved.

Neuronal clues to vascular guidance.

PubMed

Suchting, Steven; Bicknell, Roy; Eichmann, Anne

2006-03-10

The development of the vertebrate vascular system into a highly ordered and stereotyped network requires precise control over the branching and growth of new vessels. Recent research has highlighted the important role of genetic programs in regulating vascular patterning and in particular has established a crucial role for families of molecules previously described in controlling neuronal guidance. Like neurons, new vessels are guided along the correct path by integrating attractive and repulsive cues from the external environment. This is achieved by specialised endothelial cells at the leading tip of vessel sprouts which express receptor proteins that couple extracellular guidance signals with the cytoskeletal changes necessary to alter cell direction. Here, we review the genetic and in vitro evidence implicating four families of ligand-receptor signalling systems common to both neuronal and vessel guidance: the Ephrins and Eph receptors; Semaphorins, Neuropilins and Plexin receptors; Netrin and Unc5 receptors; and Slits and Robo receptors.

Application of Targeted Functional Assays to Assess a Putative Vascular Disruption Developmental Toxicity Pathway Informed By ToxCast High-Throughput Screening Data

EPA Science Inventory

Chemical perturbation of vascular development is a putative toxicity pathway which may result in developmental toxicity. EPA’s high-throughput screening (HTS) ToxCast program contains assays which measure cellular signals and biological processes critical for blood vessel develop...

78 FR 68764 - Fisheries Off West Coast States; Pacific Coast Groundfish Fishery Management Plan; Commercial...

Federal Register 2010, 2011, 2012, 2013, 2014

2013-11-15

... (coop) programs for the at-sea mothership and catcher/processor trawl fleets (whiting only). Since that... permit holder (vessel owner) to change their vessel ownership, 9. Clarify that the processor obligation..., Mothership Coop (MS) Program--Whiting At-sea Trawl Fishery, and Catcher-Processor (C/P) Coop Program--Whiting...

46 CFR 71.50-15 - Description of the Alternative Hull Examination (AHE) Program for certain passenger vessels.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 46 Shipping 3 2010-10-01 2010-10-01 false Description of the Alternative Hull Examination (AHE... Description of the Alternative Hull Examination (AHE) Program for certain passenger vessels. The Alternative Hull Examination (AHE) Program provides you with an alternative to a drydock examination by allowing...

46 CFR 176.620 - Description of the Alternative Hull Examination (AHE) Program for certain passenger vessels.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 46 Shipping 7 2010-10-01 2010-10-01 false Description of the Alternative Hull Examination (AHE... Hull and Tailshaft Examinations § 176.620 Description of the Alternative Hull Examination (AHE) Program for certain passenger vessels. The Alternative Hull Examination (AHE) Program provides you with an...

46 CFR 71.50-31 - Continued participation in the Alternative Hull Examination (AHE) program.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 46 Shipping 3 2010-10-01 2010-10-01 false Continued participation in the Alternative Hull... the Alternative Hull Examination (AHE) program. (a) To continue to participate in the AHE Program, vessel operators must conduct an annual hull condition assessment. At a minimum, vessel operators must...

Image Processing System

NASA Technical Reports Server (NTRS)

1986-01-01

Mallinckrodt Institute of Radiology (MIR) is using a digital image processing system which employs NASA-developed technology. MIR's computer system is the largest radiology system in the world. It is used in diagnostic imaging. Blood vessels are injected with x-ray dye, and the images which are produced indicate whether arteries are hardened or blocked. A computer program developed by Jet Propulsion Laboratory known as Mini-VICAR/IBIS was supplied to MIR by COSMIC. The program provides the basis for developing the computer imaging routines for data processing, contrast enhancement and picture display.

75 FR 52722 - Taking and Importing of Marine Mammals

Federal Register 2010, 2011, 2012, 2013, 2014

2010-08-27

... International Dolphin Conservation Program (IDCP) by Spanish flag purse seine vessels or purse seine vessels operating under Spanish jurisdiction to be imported into the United States. The affirmative finding was... ETP by Spanish- flag purse seine vessels or purse seine vessels operating under Spanish jurisdiction...

Roadmap for Nondestructive Evaluation of Reactor Pressure Vessel Research and Development by the Light Water Reactor Sustainability Program

DOE Office of Scientific and Technical Information (OSTI.GOV)

Smith, Cyrus M; Nanstad, Randy K; Clayton, Dwight A

2012-09-01

The Department of Energy s (DOE) Light Water Reactor Sustainability (LWRS) Program is a five year effort which works to develop the fundamental scientific basis to understand, predict, and measure changes in materials and systems, structure, and components as they age in environments associated with continued long-term operations of existing commercial nuclear power reactors. This year, the Materials Aging and Degradation (MAaD) Pathway of this program has placed emphasis on emerging Non-Destructive Evaluation (NDE) methods which support these objectives. DOE funded Research and Development (R&D) on emerging NDE techniques to support commercial nuclear reactor sustainability is expected to begin nextmore » year. This summer, the MAaD Pathway invited subject matter experts to participate in a series of workshops which developed the basis for the research plan of these DOE R&D NDE activities. This document presents the results of one of these workshops which are the DOE LWRS NDE R&D Roadmap for Reactor Pressure Vessels (RPV). These workshops made a substantial effort to coordinate the DOE NDE R&D with that already underway or planned by the Electric Power Research Institute (EPRI) and the Nuclear Regulatory Commission (NRC) through their representation at these workshops.« less

Vessel Loading Observations

DOT National Transportation Integrated Search

1999-01-01

Vessel Loading Observations Procedures for P.L. 480, Titles II & III, : Section 416(b) and Food for Progress programs. Notice advises steamship lines and other interested parties that the vessel loading observation (VLO) procedure will continue to be...

50 CFR 648.15 - Facilitation of enforcement.

Code of Federal Regulations, 2010 CFR

2010-10-01

... ocean quahog open access permitted vessels. Vessel owners or operators issued an open access surfclam or ocean quahog open access permit for fishing in the ITQ Program, as specified at § 648.70, are required... limited access permitted vessels. Beginning January 1, 2009, vessel owners or operators issued a limited...

Material Issues in Space Shuttle Composite Overwrapped Pressure Vessels

NASA Technical Reports Server (NTRS)

Sutter, James K.; Jensen, Brian J.; Gates, Thomas S.; Morgan, Roger J.; Thesken, John C.; Phoenix, S. Leigh

2006-01-01

Composite Overwrapped Pressure Vessels (COPV) store gases used in four subsystems for NASA's Space Shuttle Fleet. While there are 24 COPV on each Orbiter ranging in size from 19-40", stress rupture failure of a pressurized Orbiter COPV on the ground or in flight is a catastrophic hazard and would likely lead to significant damage/loss of vehicle and/or life and is categorized as a Crit 1 failure. These vessels were manufactured during the late 1970's and into the early 1980's using Titanium liners, Kevlar 49 fiber, epoxy matrix resin, and polyurethane coating. The COPVs are pressurized periodically to 3-5ksi and therefore experience significant strain in the composite overwrap. Similar composite vessels were developed in a variety of DOE Programs (primarily at Lawrence Livermore National Laboratories or LLNL), as well as for NASA Space Shuttle Fleet Leader COPV program. The NASA Engineering Safety Center (NESC) formed an Independent Technical Assessment (ITA) team whose primary focus was to investigate whether or not enough composite life remained in the Shuttle COPV in order to provide a strategic rationale for continued COPV use aboard the Space Shuttle Fleet with the existing 25-year-old vessels. Several material science issues were examined and will be discussed in this presentation including morphological changes to Kevlar 49 fiber under stress, manufacturing changes in Kevlar 49 and their effect on morphology and tensile strength, epoxy resin strain, composite creep, degradation of polyurethane coatings, and Titanium yield characteristics.

An automated program for reinforcement requirements for openings in cylindrical pressure vessels

NASA Technical Reports Server (NTRS)

Wilson, J. F.; Taylor, J. T.

1975-01-01

An automated interactive program for calculating the reinforcement requirements for openings in cylindrical pressure vessels subjected to internal pressure is described. The program is written for an electronic desk top calculator. The program calculates the required area of reinforcement for a given opening and compares this value with the area of reinforcement provided by a proposed design. All program steps, operating instructions, and example problems with input and sample output are documented.

Inland Waters Night Lighting Configurations: A Navigation Rules Course for Coast Guard Auxiliarists.

ERIC Educational Resources Information Center

Griffiths, Gregory Peter

A project developed a training program to teach boaters to recognize and interpret properly the lights of other vessels in nighttime or other reduced visibility conditions in the inland waters of the United States. The project followed the Instructional Systems Design model in the development of the course. The target population were members of…

46 CFR 296.20 - Tank vessels.

Code of Federal Regulations, 2011 CFR

2011-10-01

... 46 Shipping 8 2011-10-01 2011-10-01 false Tank vessels. 296.20 Section 296.20 Shipping MARITIME... SECURITY PROGRAM (MSP) Priority for Granting Applications § 296.20 Tank vessels. (a) First priority for the award of MSP Operating Agreements under MSA 2003 shall be granted to a tank vessel that is constructed...

46 CFR 296.20 - Tank vessels.

Code of Federal Regulations, 2013 CFR

2013-10-01

... 46 Shipping 8 2013-10-01 2013-10-01 false Tank vessels. 296.20 Section 296.20 Shipping MARITIME... SECURITY PROGRAM (MSP) Priority for Granting Applications § 296.20 Tank vessels. (a) First priority for the award of MSP Operating Agreements under MSA 2003 shall be granted to a tank vessel that is constructed...

46 CFR 296.20 - Tank vessels.

Code of Federal Regulations, 2014 CFR

2014-10-01

... 46 Shipping 8 2014-10-01 2014-10-01 false Tank vessels. 296.20 Section 296.20 Shipping MARITIME... SECURITY PROGRAM (MSP) Priority for Granting Applications § 296.20 Tank vessels. (a) First priority for the award of MSP Operating Agreements under MSA 2003 shall be granted to a tank vessel that is constructed...

46 CFR 296.20 - Tank vessels.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 46 Shipping 8 2010-10-01 2010-10-01 false Tank vessels. 296.20 Section 296.20 Shipping MARITIME... SECURITY PROGRAM (MSP) Priority for Granting Applications § 296.20 Tank vessels. (a) First priority for the award of MSP Operating Agreements under MSA 2003 shall be granted to a tank vessel that is constructed...

46 CFR 296.20 - Tank vessels.

Code of Federal Regulations, 2012 CFR

2012-10-01

... 46 Shipping 8 2012-10-01 2012-10-01 false Tank vessels. 296.20 Section 296.20 Shipping MARITIME... SECURITY PROGRAM (MSP) Priority for Granting Applications § 296.20 Tank vessels. (a) First priority for the award of MSP Operating Agreements under MSA 2003 shall be granted to a tank vessel that is constructed...

76 FR 57797 - Requested Administrative Waiver of the Coastwise Trade Laws: Vessel JUBILEE; Invitation for...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-09-16

... JUBILEE is: Intended Commercial use of Vessel: ``Vessel will be used in sailing school program to teach basic sailing, bareboat charter, coastal and offshore navigation, basic cruising and basic racing...

Studies on in-vessel debris coolability in ALPHA program

DOE Office of Scientific and Technical Information (OSTI.GOV)

Maruyama, Yu; Yamano, Norihiro; Moriyama, Kiyofumi

1997-02-01

In-vessel debris coolability experiments have been performed in ALPHA Program at JAERI. Aluminum oxide (Al{sub 2}O{sub 3}) produced by a thermite reaction was applied as a debris simulant. Two scoping experiments using approximately 30 kg or 50 kg of Al{sub 2}O{sub 3} were conducted. In addition to post-test observations, temperature histories of the debris simulant and the lower head experimental vessel were evaluated. Rapid temperature reduction observed on the outer surface of the experimental vessel may imply that water penetration into a gap between the solidified debris and the experimental vessel occurred resulting in an effective cooling of once heatedmore » vessel wall. Preliminary measurement of a gap width was made with an ultrasonic device. Signals to show the existence of gaps, ranging from 0.7 mm to 1.4 mm, were detected at several locations.« less

An improved correlation procedure for subsize and full-size Charpy impact specimen data

DOE Office of Scientific and Technical Information (OSTI.GOV)

Sokolov, M.A.; Alexander, D.J.

1997-03-01

The possibility of using subsize specimens to monitor the properties of reactor pressure vessel steels is receiving increasing attention for light-water reactor plant life extension. This potential results from the possibility of cutting samples of small volume form the internal surface of the pressure vessel for determination of the actual properties of the operating pressure vessel. In addition, plant life extension will require supplemental data that cannot be provided by existing surveillance programs. Testing of subsize specimens manufactured from broken halves of previously tested surveillance Charpy specimens offers an attractive means of extending existing surveillance programs. Using subsize Charpy V-notch-typemore » specimens requires the establishment of a specimen geometry that is adequate to obtain a ductile-to-brittle transition curve similar to that obtained from full-size specimens, and the development of correlations for transition temperature and upper-shelf energy (USE) level between subsize and full-size specimens. Five different geometries of subsize specimens were selected for testing and evaluation. The specimens were made from several types of pressure vessel steels with a wide range of yield strengths, transition temperatures, and USEs. The effects of specimen dimensions, including notch depth, angle, and radius, have been studied. The correlations of transition temperatures determined from different types of subsize specimens and the full-size specimens are presented. A new procedure for transforming data from subsize specimens is developed. The transformed data are in good agreement with data from full-size specimens for materials that have USE levels less than 200 J.« less

50 CFR 648.62 - Northern Gulf of Maine (NGOM) scallop management area.

Code of Federal Regulations, 2010 CFR

2010-10-01

... vessels fishing under the scallop DAS program shall not be deducted from the NGOM total allowable catch... to § 648.4(a)(2)(i) that have declared a trip under the scallop DAS program, a vessel issued a... pursuant to § 648.4(a)(2)(i) that have properly declared a trip under the scallop DAS program, the combined...

Soundwatch: Eighteen years of monitoring whale watch vessel activities in the Salish Sea

PubMed Central

Osborne, Richard W.; Koski, Kari

2017-01-01

The Soundwatch Boater Education Program is a vessel monitoring and public education outreach program. Soundwatch has been run by The Whale Museum (TWM) during the whale watch season (May through September) in the Haro Strait Region of the Central Salish Sea since 1993. Data collection has been in a consistent manner since 1998 and is presented here. The program compiles data on vessel types and vessel interactions with marine mammals with a focus on the Southern Resident killer whale (SRKW), Orcinas orca, which was listed as endangered under the U.S. Endangered Species Act (ESA) in 2005. The primary goal of the Soundwatch program is to reduce vessel disturbance to SRKWs and other marine wildlife through the education of boaters on regional, local and federal guidelines and regulations and the systematic monitoring of vessel activities around cetaceans. Since 1998, the number of active commercial whale watching vessels has increased over time; ranging from a low of 63 in 1999, to a high of 96 in 2015. In addition, the number of vessel incidents or violation of regulations and guidelines has also increased; ranging from a low of 398 in 1998 to a high of 2621 in 2012. Soundwatch collected data on 23 incident types, some remaining the same over the 18-year data set and some changing over time. The most common incidents over the 18 years were “Within 880 m of Lime Kiln” and “Crossing the path of whales”. The numbers of people kayaking near whales also significantly increased since 2004 with the incident “kayaks spread out” with a significantly increasing trend making it difficult for whales to avoid vessels. These results suggest a need for further outreach for effective education and enforcement of whale watching guidelines and regulations in the Central Salish Sea. PMID:29272275

Venezuela offshore oil and gas production development: Past, present and future

DOE Office of Scientific and Technical Information (OSTI.GOV)

Perez La Salvia, H.; Schwartz, E.; Contreras, M.

1995-12-01

This paper presents a short history of offshore oil and gas production in Venezuela starting in Lake Maracaibo in 1923. The main emphasis has been the results of the recent R and D and the exploratory offshore programs in areas like Orinoco Delta located in the Atlantic Ocean, Northeast and Northwest Venezuela in the Caribbean sea. In the R and D offshore program the main objectives were: (1) To establish the local environmental, oceanographical, geotechnical and seismicity conditions for the Venezuelan Continental Platform. (2) To give a technical support to the PDVSA Operating Affiliates during the exploratory programs including: (a)more » to develop accurate drilling vessel positioning systems; (b) evaluation of sea bottom geotechnical conditions for safely operating the jack-ups and drilling vessels involved in the exploratory wells and (c) to identify those areas which because of their special nature require further investigation to establish preliminary type of platforms required for the areas to be developed or to evaluate other solutions proposed by Foreign Consultant Engineering Companies to the PDVSA Operating Affiliated Companies. The main objective of PDVSA for the coming future will be to develop the North of Paria Gas Field through the initially named Christopher Columbus Project now Sucre Gas, S.A., a consortium conformed by LaGoven, S.A. Shell, Exxon and Mitsubishi. objective of this paper is to give an idea of the history of the Venezuelan Oil and Gas Offshore development giving emphasis to the results of the INTEVEP S.A. Red offshore program and to show some results of the particular characteristics of oceanographical, environmental, geotechnical and seismic conditions in the main areas evaluated during the exploratory program: Orinoco Delta, Gulf of Paria and North of Paria.« less

Fracture toughness testing of Linde 1092 reactor vessel welds in the transition range using Charpy-sized specimens

DOE Office of Scientific and Technical Information (OSTI.GOV)

Pavinich, W.A.; Yoon, K.K.; Hour, K.Y.

1999-10-01

The present reference toughness method for predicting the change in fracture toughness can provide over estimates of these values because of uncertainties in initial RT{sub NDT} and shift correlations. It would be preferable to directly measure fracture toughness. However, until recently, no standard method was available to characterize fracture toughness in the transition range. ASTM E08 has developed a draft standard that shows promise for providing lower bound transition range fracture toughness using the master curve approach. This method has been successfully implemented using 1T compact fracture specimens. Combustion Engineering reactor vessel surveillance programs do not have compact fracture specimens.more » Therefore, the CE Owners Group developed a program to validate the master curve method for Charpy-sized and reconstituted Charpy-sized specimens for future application on irradiated specimens. This method was validated for Linde 1092 welds using unirradiated Charpy-sized and reconstituted Charpy-sized specimens by comparison of results with those from compact fracture specimens.« less

75 FR 3746 - Draft Program Comment for the Department of the Navy for the Disposition of Historic Vessels

Federal Register 2010, 2011, 2012, 2013, 2014

2010-01-22

... less than fifty years. Because naval vessels have a limited useful life, the Chief of Naval Operations undertakes a Ship Disposition Review (SDR) each year to determine whether any vessels should be... service for typically less than fifty years. Because naval vessels have a limited useful life, the Chief...

CRADA opportunities with METC`s gasification and hot gas cleanup facility

DOE Office of Scientific and Technical Information (OSTI.GOV)

Galloway, E N; Rockey, J M; Tucker, M S

1995-06-01

Opportunities exist for Cooperative Research and Development Agreements (CRADA) at the Morgantown Energy Technology Center (METC) to support commercialization of IGCC power systems. METC operates an integrated gasifier and hot gas cleanup facility for the development of gasification and hot gas cleanup technologies. The objective of our program is to gather performance data on gasifier operation, particulate removal, desulfurization and regeneration technologies. Additionally, slip streams are provided for developing various technologies such as; alkali monitoring, particulate measuring, chloride removal, and contaminate recovery processes. METC`s 10-inch diameter air blown Fluid Bed Gasifier (FBG) provides 300 lb/hr of coal gas at 1100{degrees}Fmore » and 425 psig. The particulate laden gas is transported to METC`s Modular Gas Cleanup Rig (MGCR). The gas pressure is reduced to 285 psig before being fed into a candle filter vessel. The candle filter vessel houses four candle filters and multiple test coupons. The particulate free gas is then desulfurized in a sorbent reactor. Starting in 1996 the MGCR system will be able to regenerate the sorbent in the same vessel.« less

Pretest Round Robin Analysis of 1:4-Scale Prestressed Concrete Containment Vessel Model

DOE Office of Scientific and Technical Information (OSTI.GOV)

HESSHEIMER,MICHAEL F.; LUK,VINCENT K.; KLAMERUS,ERIC W.

The purpose of the program is to investigate the response of representative scale models of nuclear containment to pressure loading beyond the design basis accident and to compare analytical predictions to measured behavior. This objective is accomplished by conducting static, pneumatic overpressurization tests of scale models at ambient temperature. This research program consists of testing two scale models: a steel containment vessel (SCV) model (tested in 1996) and a prestressed concrete containment vessel (PCCV) model, which is the subject of this paper.

Developing a new hybrid revascularization program: a road map for hospital managers and physician leaders.

PubMed

Harjai, Kishore J; Samy, Sanjay; Pennypacker, Barbara; Onofre, Bonnie; Stanfield, Pamela; Yaeger, Lynne; Stapleton, Dwight; Esrig, Barry C

2012-12-01

Hybrid coronary revascularization, which involves minimally invasive direct coronary artery bypass surgery using the left internal mammary artery to left anterior descending and percutaneous coronary intervention using drug-eluting stents for the remaining diseased coronary vessels, is an innovative approach to decrease the morbidity of conventional surgery. Little information is available to guide hospital managers and physician leaders in implementing a hybrid revascularization program. In this article, we describe the people-process-technology issues that managers and leaders are likely to encounter as they develop a hybrid revascularization program in their practice. ©2012, Wiley Periodicals, Inc.

Determination of the Crack Resistance Parameters at Equipment Nozzle Zones Under the Seismic Loads Via Finite Element Method

NASA Astrophysics Data System (ADS)

Kyrychok, Vladyslav; Torop, Vasyl

2018-03-01

The present paper is devoted to the problem of the assessment of probable crack growth at pressure vessel nozzles zone under the cyclic seismic loads. The approaches to creating distributed pipeline systems, connected to equipment are being proposed. The possibility of using in common different finite element program packages for accurate estimation of the strength of bonded pipelines and pressure vessels systems is shown and justified. The authors propose checking the danger of defects in nozzle domain, evaluate the residual life of the system, basing on the developed approach.

Training Caribbean Trawlermen for the Future

ERIC Educational Resources Information Center

Findlay, Peter

1975-01-01

Equipped with two multi-purpose fishing vessels, the Caribbean Fishery Development Institute has begun training 45 persons in an 11-month course ranging from navigation to seamanship, from engineering to biology, law, andeconomics. The program description provided by the article is supplemented by figures offering specific curricular and…

NASA's Software Bank (Heath Tecna Aerospace)

NASA Technical Reports Server (NTRS)

1991-01-01

Heath Tecna Aerospace used a COSMIC program, "Analysis of Filament Reinforced Metal Shell Pressure Vessels," to predict stresses in motorcase walls in a composite hybrid rocket and calculate the ideal geometry for the domes at either end of the filament-wound pressure vessel. The COSMIC program predictions were confirmed in testing.

75 FR 7599 - Notice of Public Hearing; Passenger Vessel Financial Responsibility

Federal Register 2010, 2011, 2012, 2013, 2014

2010-02-22

... FEDERAL MARITIME COMMISSION Notice of Public Hearing; Passenger Vessel Financial Responsibility AGENCY: Federal Maritime Commission. ACTION: Public hearing; extension of time to file requests to appear... testimony concerning the Commission's Passenger Vessel Financial Responsibility Program. DATES: The due date...

Computer quantitation of coronary angiograms

NASA Technical Reports Server (NTRS)

Ledbetter, D. C.; Selzer, R. H.; Gordon, R. M.; Blankenhorn, D. H.; Sanmarco, M. E.

1978-01-01

A computer technique is being developed at the Jet Propulsion Laboratory to automate the measurement of coronary stenosis. A Vanguard 35mm film transport is optically coupled to a Spatial Data System vidicon/digitizer which in turn is controlled by a DEC PDP 11/55 computer. Programs have been developed to track the edges of the arterial shadow, to locate normal and atherosclerotic vessel sections and to measure percent stenosis. Multiple frame analysis techniques are being investigated that involve on the one hand, averaging stenosis measurements from adjacent frames, and on the other hand, averaging adjacent frame images directly and then measuring stenosis from the averaged image. For the latter case, geometric transformations are used to force registration of vessel images whose spatial orientation changes.

75 FR 12245 - Program Comment for the Department of the Navy for the Disposition of Historic Vessels

Federal Register 2010, 2011, 2012, 2013, 2014

2010-03-15

... way and remain in active service for typically less than fifty years. Because naval vessels have a limited useful life, the Chief of Naval Operations undertakes a Ship Disposition Review (SDR) each year to... decommissioned in the following year and when the Navy would strike those historic vessels from the Naval Vessel...

50 CFR 648.82 - Effort-control program for NE multispecies limited access vessels.

Code of Federal Regulations, 2012 CFR

2012-10-01

... time at sea assisting in a USCG search and rescue operation or assisting the USCG in towing a disabled... only may lease DAS to a Lessee vessel with a baseline main engine horsepower rating that is no more than 20 percent greater than the baseline engine horsepower of the Lessor vessel. A Lessor vessel may...

75 FR 56903 - Pacific Halibut Fisheries; Limited Access for Guided Sport Charter Vessels in Alaska

Federal Register 2010, 2011, 2012, 2013, 2014

2010-09-17

.... 100503209-0430-02] RIN 0648-AY85 Pacific Halibut Fisheries; Limited Access for Guided Sport Charter Vessels... program for charter vessels in the guided sport fishery for Pacific halibut in the waters of International... sport fishing for halibut and charter vessels in IPHC Areas 2C and 3A may be found in sections 3, 25...

75 FR 38758 - Pacific Halibut Fisheries; Limited Access for Guided Sport Charter Vessels in Alaska

Federal Register 2010, 2011, 2012, 2013, 2014

2010-07-06

.... 100503209-0215-01] RIN 0648-AY85 Pacific Halibut Fisheries; Limited Access for Guided Sport Charter Vessels... that would amend the limited access program for charter vessels in the guided sport fishery for Pacific... 13024). IPHC regulations affecting sport fishing for halibut and charter vessels in IPHC Areas 2C and 3A...

METHODOLOGIES FOR ESTIMATING AIR EMISSIONS FROM THREE NON-TRADITIONAL SOURCE CATEGORIES: OIL SPILLS, PETROLEUM VESSEL LOADING & UNLOADING, AND COOLING TOWERS

EPA Science Inventory

The report discusses part of EPA's program to identify and characterize emissions sources not currently accounted for by either the existing Aerometric Information Retrieval System (AIRS) or State Implementation Plan (sip) area source methodologies and to develop appropriate emis...

78 FR 35090 - Agency Information Collection Activity Under OMB Review; Reports, Forms and Recordkeeping...

Federal Register 2010, 2011, 2012, 2013, 2014

2013-06-11

... forwarded to the Office of Management and Budget (OMB) for review and approval. The nature of the... qualified vessels in the Maritime Security Program Fleet. Applications and amendments are used to select vessels for the fleet. Periodic reporting is used to monitor adherence of contractors to program...

76 FR 6182 - Reports, Forms and Recordkeeping Requirements; Agency Information Collection Activity Under OMB...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-02-03

... forwarded to the Office of Management and Budget (OMB) for review and approval. The nature of the... qualified vessels in the Maritime Security Program Fleet. Applications and amendments are used to select vessels for the fleet. Periodic reporting is used to monitor adherence of contractors to program...

46 CFR 115.620 - Description of the Alternative Hull Examination (AHE) Program for certain passenger vessels.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 46 Shipping 4 2010-10-01 2010-10-01 false Description of the Alternative Hull Examination (AHE... ACCOMMODATIONS FOR MORE THAN 49 PASSENGERS INSPECTION AND CERTIFICATION Hull and Tailshaft Examinations § 115.620 Description of the Alternative Hull Examination (AHE) Program for certain passenger vessels. The Alternative...

78 FR 23540 - Fisheries in the Western Pacific; American Samoa Pelagic Longline Limited Entry Program

Federal Register 2010, 2011, 2012, 2013, 2014

2013-04-19

... individual wage record, ownership title, vessel registration, or other official documents. The documents must show either ownership of a vessel that was used to fish in the EEZ around American Samoa, or evidence... the Western Pacific; American Samoa Pelagic Longline Limited Entry Program AGENCY: National Marine...

CG Vessel Traffic Service Program.

DTIC Science & Technology

1980-06-01

Corps of Engineers and the Maritime Administration have forecast that total commercial cargo transported through U.S. ports and waterways will increase... electronic navigation and surveillance equipment since the early 1960’s to evaluate various concepts by which vessel traffic safety could be enhanced...relatively complete data base on vessel traffic. On the other hand, the addition of radar and other electronic surveillance should: --Prevent vessel

Effectiveness of voluntary conservation agreements: case study of endangered whales and commercial whale watching.

PubMed

Wiley, David N; Moller, Just C; Pace, Richard M; Carlson, Carole

2008-04-01

The use of voluntary approaches to achieve conservation goals is becoming increasingly popular. Nevertheless, few researchers have quantitatively evaluated their efficacy. In 1998 industry, government agencies, and nongovernmental organizations established a voluntary conservation program for whale watching in the northeast region of the United States, with the intent to avoid collisions with and harassment of endangered whales by commercial and recreational whale-watching vessels. One important aspect of the program was the establishment of 3 speed zones within specific distances of whales. We wanted to determine the level of compliance with this aspect of the program to gauge its efficacy and gain insights into the effectiveness of voluntary measures as a conservation tool. Inconspicuous observers accompanied 46 commercial whale-watching trips from 12 companies in 2003 (n= 35) and 2004 (n= 11). During each trip, vessel position and speed were collected at 5-second intervals with a GPS receiver. Binoculars with internal laser rangefinders and digital compasses were used to record range and bearing to sighted whales. We mapped whale locations with ArcGIS. We created speed-zone buffers around sighted whales and overlaid them with vessel-track and speed data to evaluate compliance. Speeds in excess of those recommended by the program were considered noncompliant. We judged the magnitude of noncompliance by comparing a vessel's maximum speed within a zone to its maximum recorded trip speed. The level of noncompliance was high (mean 0.78; company range 0.74-0.88), some companies were more compliant than others (p= 0.02), noncompliance was significantly higher in zones farther from whales (p < 0.001), and operators approached the maximum speed capabilities of their vessel in all zones. The voluntary conservation program did not achieve the goal of substantially limiting vessel speed near whales. Our results support the need for conservation programs to have quantifiable metrics and frequent evaluation to ensure efficacy.

Fracture Analysis of Vessels. Oak Ridge FAVOR, v06.1, Computer Code: Theory and Implementation of Algorithms, Methods, and Correlations

DOE Office of Scientific and Technical Information (OSTI.GOV)

Williams, P. T.; Dickson, T. L.; Yin, S.

The current regulations to insure that nuclear reactor pressure vessels (RPVs) maintain their structural integrity when subjected to transients such as pressurized thermal shock (PTS) events were derived from computational models developed in the early-to-mid 1980s. Since that time, advancements and refinements in relevant technologies that impact RPV integrity assessment have led to an effort by the NRC to re-evaluate its PTS regulations. Updated computational methodologies have been developed through interactions between experts in the relevant disciplines of thermal hydraulics, probabilistic risk assessment, materials embrittlement, fracture mechanics, and inspection (flaw characterization). Contributors to the development of these methodologies include themore » NRC staff, their contractors, and representatives from the nuclear industry. These updated methodologies have been integrated into the Fracture Analysis of Vessels -- Oak Ridge (FAVOR, v06.1) computer code developed for the NRC by the Heavy Section Steel Technology (HSST) program at Oak Ridge National Laboratory (ORNL). The FAVOR, v04.1, code represents the baseline NRC-selected applications tool for re-assessing the current PTS regulations. This report is intended to document the technical bases for the assumptions, algorithms, methods, and correlations employed in the development of the FAVOR, v06.1, code.« less

50 CFR 679.81 - Rockfish Program annual harvester privileges.

Code of Federal Regulations, 2012 CFR

2012-10-01

...) Maximum retainable amount (MRA) limits—(1) Rockfish cooperative. A vessel assigned to a rockfish... those species as established in Table 10 to this part. (4) Maximum retainable amount (MRA) calculation and limits—catcher vessels. (i) The MRA for an incidental catch species for vessels fishing under the...

50 CFR 679.81 - Rockfish Program annual harvester privileges.

Code of Federal Regulations, 2013 CFR

2013-10-01

...) Maximum retainable amount (MRA) limits—(1) Rockfish cooperative. A vessel assigned to a rockfish... those species as established in Table 10 to this part. (4) Maximum retainable amount (MRA) calculation and limits—catcher vessels. (i) The MRA for an incidental catch species for vessels fishing under the...

50 CFR 679.81 - Rockfish Program annual harvester privileges.

Code of Federal Regulations, 2014 CFR

2014-10-01

...) Maximum retainable amount (MRA) limits—(1) Rockfish cooperative. A vessel assigned to a rockfish... those species as established in Table 10 to this part. (4) Maximum retainable amount (MRA) calculation and limits—catcher vessels. (i) The MRA for an incidental catch species for vessels fishing under the...

77 FR 50086 - Taking and Importing of Marine Mammals

Federal Register 2010, 2011, 2012, 2013, 2014

2012-08-20

... International Dolphin Conservation Program (IDCP) by Spanish-flag purse seine vessels or purse seine vessels operating under Spanish jurisdiction to be imported into the United States. The affirmative finding was... derived from yellowfin tuna harvested in the ETP by Spanish-flag purse seine vessels or purse seine...

Research Methods to Develop Measures of Effectiveness of the United States Coast Guard’s Vessel Inspection and Boarding Program. Executive Summary - Volume I

DTIC Science & Technology

1995-05-01

Service, Springfield, Virginia 22161 Prepared for: LJCý U.S. Coast Guard Research and Development Center 1082 Shennecossett Road < Groton, Connecticut...States Coast Guard Research & Development Center 1082 Shennecossett Road Groton, CT 06340-6096 ii Technical Report Documentation Paae 1. Report No. 2...U.S. Coast Guard 14. Sponsoring Agency Code Research and Development Center Office of Engineering, Logistics, 1082 Shennecossett Road and Development

50 CFR 648.92 - Effort-control program for monkfish limited access vessels.

Code of Federal Regulations, 2010 CFR

2010-10-01

... may not fish for, possess, retain, or land monkfish, except during a DAS as allocated under and in accordance with the applicable DAS program described in this section, except as otherwise provided in this... limited access monkfish vessel that has unused monkfish DAS on the last day of April of any year may carry...

50 CFR 622.16 - Gulf red snapper individual fishing quota (IFQ) program.

Code of Federal Regulations, 2010 CFR

2010-10-01

... on hardship factors will not be considered. Appeals must be submitted to the RA postmarked no later... location of transaction; weight and actual ex-vessel value of red snapper landed and sold; and information... of the Gulf red snapper IFQ program. The fee cannot exceed 3 percent of the ex-vessel value of Gulf...

50 CFR 622.16 - Gulf red snapper individual fishing quota (IFQ) program.

Code of Federal Regulations, 2011 CFR

2011-10-01

... on hardship factors will not be considered. Appeals must be submitted to the RA postmarked no later... location of transaction; weight and actual ex-vessel value of red snapper landed and sold; and information... of the Gulf red snapper IFQ program. The fee cannot exceed 3 percent of the ex-vessel value of Gulf...

22 CFR 126.6 - Foreign-owned military aircraft and naval vessels, and the Foreign Military Sales program.

Code of Federal Regulations, 2010 CFR

2010-04-01

... 22 Foreign Relations 1 2010-04-01 2010-04-01 false Foreign-owned military aircraft and naval vessels, and the Foreign Military Sales program. 126.6 Section 126.6 Foreign Relations DEPARTMENT OF STATE INTERNATIONAL TRAFFIC IN ARMS REGULATIONS GENERAL POLICIES AND PROVISIONS § 126.6 Foreign-owned military...

Spin Forming of an Aluminum 2219-T6 Aft Bulkhead for the Orion Multi-Purpose Crew Vehicle: Phase II Supplemental Report

NASA Technical Reports Server (NTRS)

Piascik, Robert S.; Squire, Michael D.; Domack, Marcia S.; Hoffman, Eric K.

2015-01-01

The principal focus of this project was to assist the Orion Multi-Purpose Crew Vehicle (MPCV) Program in developing a spin forming fabrication process for manufacture of the aft bulkhead of the pressure vessel. The spin forming process will enable a single piece aluminum (Al) 2219 aft bulkhead which will eliminate the current multiple piece welded construction, simplify fabrication, and lead to an enhanced design that will reduce vehicle weight by eliminating welds. Phase I of this assessment explored spin forming the single-piece forward pressure vessel bulkhead from aluminum-lithium 2195.

Proactive life extension of pressure vessels

NASA Astrophysics Data System (ADS)

Mager, Lloyd

1998-03-01

For a company to maintain its competitive edge in today's global market every opportunity to gain an advantage must be exploited. Many companies are strategically focusing on improved utilization of existing equipment as well as regulatory compliance. Abbott Laboratories is no exception. Pharmaceutical companies such as Abbott Laboratories realize that reliability and availability of their production equipment is critical to be successful and competitive. Abbott Laboratories, like many of our competitors, is working to improve safety, minimize downtime and maximize the productivity and efficiency of key production equipment such as the pressure vessels utilized in our processes. The correct strategy in obtaining these objectives is to perform meaningful inspection with prioritization based on hazard analysis and risk. The inspection data gathered in Abbott Laboratories pressure vessel program allows informed decisions leading to improved process control. The results of the program are reduced risks to the corporation and employees when operating pressure retaining equipment. Accurate and meaningful inspection methods become the cornerstone of a program allowing proper preventative maintenance actions to occur. Successful preventative/predictive maintenance programs must utilize meaningful nondestructive evaluation techniques and inspection methods. Nondestructive examination methods require accurate useful tools that allow rapid inspection for the entire pressure vessel. Results from the examination must allow the owner to prove compliance of all applicable regulatory laws and codes. At Abbott Laboratories the use of advanced NDE techniques, primarily B-scan ultrasonics, has provided us with the proper tools allowing us to obtain our objectives. Abbott Laboratories uses B-scan ultrasonics utilizing a pulse echo pitch catch technique to provide essential data on our pressure vessels. Equipment downtime is reduced because the nondestructive examination usually takes place while our vessels are in service. As the inspection takes place we are able to view a real time image of detected discontinuities on a video monitor. The B-scan ultrasonic technique is allowing us to perform fast accurate examinations covering up to 95% of the surface area of each pressure vessel. Receiving data on 95% of a pressure vessel provides us with a lot of useful information. We use this data to determine the condition of each pressure vessel. Once the condition is known the vessels are classed by risk. The risk level is then managed by making decisions related to repair, operating parameters, accepting and monitoring or replacement of the equipment. Inspection schedules are set at maximum intervals and reinspection is minimized for the vessels that are not at risk. The remaining life of each pressure vessel is determined, mechanical integrity is proven and regulatory requirements are met. Abbott Laboratories is taking this proactive approach because we understand that our process equipment is a critical element for successful operation. A run to failure practice would never allow Abbott Laboratories to achieve the corporation's objective of being the world's leading health care company. Nondestructive state of the art technology and the understanding of its capabilities and limitations are key components of a proactive program for life extension of pressure vessels. 26

New Approaches for Early Detection of Breast Tumor Invasion or Progression

DTIC Science & Technology

2003-05-01

IMMUNOHISTOCHEMICAL ASSESSMENT OF \\ Breast Disease PRIMARY LESIONS OF BREAST EPITHELIAL February 13-16, 2003 INVASION INTO BLOOD VESSELS Ritz - Carlton , Amelia...Programs, The Idea Award (BCOOI 187) and Career Development m ~ ~ ~ ~ ~ wr g .••• m Vol 16,’ No MEETING March 22 - 28, 2003 Marriott Wardman Park Hotel

Large-Scale Dynamic Observation Planning for Unmanned Surface Vessels

DTIC Science & Technology

2007-06-01

programming language. In addition, the useful development software NetBeans IDE is free and makes the use of Java very user-friendly. 92...3. We implemented the greedy and 3PAA algorithms in Java using the NetBeans IDE version 5.5. 4. The test datasets were generated in MATLAB. 5

Vessel-Mounted ADCP Data Calibration and Correction

NASA Astrophysics Data System (ADS)

de Andrade, A. F.; Barreira, L. M.; Violante-Carvalho, N.

2013-05-01

A set of scripts for vessel-mounted ADCP (Acoustic Doppler Current Profiler) data processing is presented. The need for corrections in the data measured by a ship-mounted ADCP and the complexities found during installation, implementation and identification of tasks performed by currently available systems for data processing consist the main motivating factors for the development of a system that would be more practical in manipulation, open code and more manageable for the user. The proposed processing system consists of a set of scripts developed in Matlab TM programming language. The system is able to read the binary files provided by the data acquisition program VMDAS (Vessel Mounted Data Acquisition System), Teledyne RDInstruments proprietary, and calculate calibration factors to correct the data and visualize them after correction. For use the new system, it is only necessary that the ADCP data collected with VMDAS program is in a processing diretory and Matlab TM software be installed on the user's computer. Developed algorithms were extensively tested with ADCP data obtained during Oceano Sul III (Southern Ocean III - OSIII) cruise, conducted by Brazilian Navy aboard the R/V "Antares", from March 26th to May 10th 2007, in the oceanic region between the states of São Paulo and Rio Grande do Sul. For read the data the function rdradcp.m, developed by Rich Pawlowicz and available on his website (http://www.eos.ubc.ca/~rich/#RDADCP), was used. To calculate the calibration factors, alignment error (α) and sensitivity error (β) in Water Tracking and Bottom Tracking Modes, equations deduced by Joyce (1998), Pollard & Read (1989) and Trump & Marmorino (1996) were implemented in Matlab. To validate the calibration factors obtained in the processing system developed, the parameters were compared with the factors provided by CODAS (Common Ocean Data Access System, available at http://currents.soest.hawaii.edu/docs/doc/index.html), post-processing program. For the same data analyzed, the factors provided by both systems were similar. Thereafter, the values obtained were used to correct the data and finally matrices were saved with data corrected and they can be plotted. The values of volume transport of the Brazil Current (BC) were calculated using the corrected data by the two systems and proved quite close, confirming the quality of the correction of the system.

Large boron--epoxy filament-wound pressure vessels

NASA Technical Reports Server (NTRS)

Jensen, W. M.; Bailey, R. L.; Knoell, A. C.

1973-01-01

Advanced composite material used to fabricate pressure vessel is prepeg (partially cured) consisting of continuous, parallel boron filaments in epoxy resin matrix arranged to form tape. To fabricate chamber, tape is wound on form which must be removable after composite has been cured. Configuration of boron--epoxy composite pressure vessel was determined by computer program.

50 CFR Table 20 to Part 679 - Seabird Avoidance Gear Requirements for Vessels, based on Area, Gear, and Vessel Type. (See § 679...

Code of Federal Regulations, 2010 CFR

2010-10-01

... 50 Wildlife and Fisheries 9 2010-10-01 2010-10-01 false Seabird Avoidance Gear Requirements for Vessels, based on Area, Gear, and Vessel Type. (See § 679.24(e) for complete seabird avoidance program requirements; see 679.24(e)(1) for applicable fisheries) 20 Table 20 to Part 679 Wildlife and Fisheries FISHERY CONSERVATION AND MANAGEMENT,...

Research subjects for analytical estimation of core degradation at Fukushima-Daiichi nuclear power plant

DOE Office of Scientific and Technical Information (OSTI.GOV)

Nagase, F.; Ishikawa, J.; Kurata, M.

2013-07-01

Estimation of the accident progress and status inside the pressure vessels (RPV) and primary containment vessels (PCV) is required for appropriate conductance of decommissioning in the Fukushima-Daiichi NPP. For that, it is necessary to obtain additional experimental data and revised models for the estimation using computer codes with increased accuracies. The Japan Atomic Energy Agency (JAEA) has selected phenomena to be reviewed and developed, considering previously obtained information, conditions specific to the Fukushima-Daiichi NPP accident, and recent progress of experimental and analytical technologies. As a result, research and development items have been picked up in terms of thermal-hydraulic behavior inmore » the RPV and PCV, progression of fuel bundle degradation, failure of the lower head of RPV, and analysis of the accident. This paper introduces the selected phenomena to be reviewed and developed, research plans and recent results from the JAEA's corresponding research programs. (authors)« less

Bound for Sydney town: health surveillance on international cruise vessels visiting the Port of Sydney.

PubMed

Ferson, Mark J; Ressler, Kelly-Anne

2005-04-18

A program for routine health surveillance on international cruise ships visiting the Port of Sydney has been developed since 1998. Before introduction of this program, ships only reported quarantinable diseases and were not aware of the Australian requirement to report other infectious diseases. Voluntary routine reporting, developed in partnership with the cruise ship industry, provides timely information on all infectious diseases of public health interest during every cruise. During 1999-2003, the program resulted in detection of and response to 14 outbreaks of gastroenteritis or acute respiratory infection, affecting more than 1400 passengers and crew. The program has improved preventive action, and risk communication and management by cruise ship operators, and led to more timely investigation and support by public health authorities.

Incorporating Hot Topics in Ocean Sciences to Outreach Activities in Marine and Environmental Science Education

NASA Astrophysics Data System (ADS)

Bergondo, D. L.; Mrakovcich, K. L.; Vlietstra, L.; Tebeau, P.; Verlinden, C.; Allen, L. A.; James, R.

2016-02-01

The US Coast Guard Academy, an undergraduate military Academy, in New London CT, provides STEM education programs to the local community that engage the public on hot topics in ocean sciences. Outreach efforts include classroom, lab, and field-based activities at the Academy as well as at local schools. In one course, we partner with a STEM high school collecting fish and environmental data on board a research vessel and subsequently students present the results of their project. In another course, cadets develop and present interactive demonstrations of marine science to local school groups. In addition, the Academy develops In another course, cadets develop and present interactive demonstrations of marine science to local school groups. In addition, the Academy develops and/or participates in outreach programs including Science Partnership for Innovation in Learning (SPIL), Women in Science, Physics of the Sea, and the Ocean Exploration Trust Honors Research Program. As part of the programs, instructors and cadets create interactive and collaborative activities that focus on hot topics in ocean sciences such as oil spill clean-up, ocean exploration, tsunamis, marine biodiversity, and conservation of aquatic habitats. Innovative science demonstrations such as real-time interactions with the Exploration Vessel (E/V) Nautilus, rotating tank simulations of ocean circulation, wave tank demonstrations, and determining what materials work best to contain and clean-up oil, are used to enhance ocean literacy. Children's books, posters and videos are some creative ways students summarize their understanding of ocean sciences and marine conservation. Despite time limitations of students and faculty, and challenges associated with securing funding to keep these programs sustainable, the impact of the programs is overwhelmingly positive. We have built stronger relationships with local community, enhanced ocean literacy, facilitated communication and mentorship between young students and scientists, and encouraged interest of underrepresented minorities in STEM education.

50 CFR 622.22 - Individual fishing quota (IFQ) program for Gulf groupers and tilefishes.

Code of Federal Regulations, 2013 CFR

2013-10-01

..., time, and location of transaction; weight and actual ex-vessel price of groupers and tilefishes landed... enforcement of the IFQ program for Gulf groupers and tilefishes. The fee cannot exceed 3 percent of the ex...). Initially, the fee will be 3 percent of the actual ex-vessel price of Gulf groupers and tilefishes landed...

Path Planning Algorithms for the Adaptive Sensor Fleet

NASA Technical Reports Server (NTRS)

Stoneking, Eric; Hosler, Jeff

2005-01-01

The Adaptive Sensor Fleet (ASF) is a general purpose fleet management and planning system being developed by NASA in coordination with NOAA. The current mission of ASF is to provide the capability for autonomous cooperative survey and sampling of dynamic oceanographic phenomena such as current systems and algae blooms. Each ASF vessel is a software model that represents a real world platform that carries a variety of sensors. The OASIS platform will provide the first physical vessel, outfitted with the systems and payloads necessary to execute the oceanographic observations described in this paper. The ASF architecture is being designed for extensibility to accommodate heterogenous fleet elements, and is not limited to using the OASIS platform to acquire data. This paper describes the path planning algorithms developed for the acquisition phase of a typical ASF task. Given a polygonal target region to be surveyed, the region is subdivided according to the number of vessels in the fleet. The subdivision algorithm seeks a solution in which all subregions have equal area and minimum mean radius. Once the subregions are defined, a dynamic programming method is used to find a minimum-time path for each vessel from its initial position to its assigned region. This path plan includes the effects of water currents as well as avoidance of known obstacles. A fleet-level planning algorithm then shuffles the individual vessel assignments to find the overall solution which puts all vessels in their assigned regions in the minimum time. This shuffle algorithm may be described as a process of elimination on the sorted list of permutations of a cost matrix. All these path planning algorithms are facilitated by discretizing the region of interest onto a hexagonal tiling.

Final Report on ITER Task Agreement 81-08

DOE Office of Scientific and Technical Information (OSTI.GOV)

Richard L. Moore

As part of an ITER Implementing Task Agreement (ITA) between the ITER US Participant Team (PT) and the ITER International Team (IT), the INL Fusion Safety Program was tasked to provide the ITER IT with upgrades to the fusion version of the MELCOR 1.8.5 code including a beryllium dust oxidation model. The purpose of this model is to allow the ITER IT to investigate hydrogen production from beryllium dust layers on hot surfaces inside the ITER vacuum vessel (VV) during in-vessel loss-of-cooling accidents (LOCAs). Also included in the ITER ITA was a task to construct a RELAP5/ATHENA model of themore » ITER divertor cooling loop to model the draining of the loop during a large ex-vessel pipe break followed by an in-vessel divertor break and compare the results to a simular MELCOR model developed by the ITER IT. This report, which is the final report for this agreement, documents the completion of the work scope under this ITER TA, designated as TA 81-08.« less

A study on the structural characteristics and shape of outfitting equipment support in 300K DWT crude oil tanker

NASA Astrophysics Data System (ADS)

Jeong, K.; Jeong, H.; Ji, M.; Kim, J.; Park, J.; Chung, H.

2015-09-01

With the increase in the size and speed of recently built vessels, the output and speed (rpm) of propulsion or generation engines have continuously increased, and the high-output, highspeed engine has become a major cause of excessive vessel noise and vibration. Accordingly, resonance occurs in the equipment and other outfitting equipment installed in a vessel, and thus, periodic requests for correction are received from ship owners or officers. In this study, to resolve this problem, supports that stably fix the outfitting equipment installed in the engine room of a very large crude oil tanker and provide protection from physical or external shock were classified into seven types for three kinds of widely used standard shapes, and an optimized shape was developed and suggested by analyzing the structural characteristics of the shapes of the supports (the maximum bending moment, maximum bending stress, and maximum deformation) using DNV NATICUS HULL 3D BEAM, a structural analysis program, so that it could be used for the outfitting design of a vessel.

THE IMPACT OF OZONE ON THE LOWER FLAMMABLE LIMIT OF HYDROGEN IN VESSELS CONTAINING SAVANNAH RIVER SITE HIGH LEVEL WASTE

DOE Office of Scientific and Technical Information (OSTI.GOV)

Sherburne, Carol; Osterberg, Paul; Johnson, Tom

The Savannah River Site, in conjunction with AREVA Federal services, has designed a process to treat dissolved radioactive waste solids with ozone. It is known that in this radioactive waste process, radionuclides radiolytically break down water into gaseous hydrogen and oxygen, which presents a well defined flammability hazard. Flammability limits have been established for both ozone and hydrogen separately; however, there is little information on mixtures of hydrogen and ozone. Therefore, testing was designed to provide critical flammability information necessary to support safety related considerations for the development of ozone treatment and potential scale-up to the commercial level. Since informationmore » was lacking on flammability issues at low levels of hydrogen and ozone, a testing program was developed to focus on filling this portion of the information gap. A 2-L vessel was used to conduct flammability tests at atmospheric pressure and temperature using a fuse wire ignition source at 1 percent ozone intervals spanning from no ozone to the Lower Flammable Limit (LFL) of ozone in the vessel, determined as 8.4%(v/v) ozone. An ozone generator and ozone detector were used to generate and measure the ozone concentration within the vessel in situ, since ozone decomposes rapidly on standing. The lower flammability limit of hydrogen in an ozone-oxygen mixture was found to decrease from the LFL of hydrogen in air, determined as 4.2 % (v/v) in this vessel. From the results of this testing, Savannah River was able to develop safety procedures and operating parameters to effectively minimize the formation of a flammable atmosphere.« less

Recent advances in lightweight, filament-wound composite pressure vessel technology

NASA Technical Reports Server (NTRS)

Lark, R. F.

1977-01-01

A review of recent advances is presented for lightweight, high-performance composite pressure vessel technology that covers the areas of design concepts, fabrication procedures, applications, and performance of vessels subjected to single-cycle burst and cyclic fatigue loading. Filament-wound fiber/epoxy composite vessels were made from S-glass, graphite, and Kevlar 49 fibers and were equipped with both structural and nonstructural liners. Pressure vessel structural efficiencies were attained which represented weight savings, using different liners, of 40 to 60 percent over all-titanium pressure vessels. Significant findings in each area are summarized including data from current NASA-Lewis Research Center contractual and in-house programs.

Vessels, Marinas and Ports

EPA Pesticide Factsheets

An overview of EPA’s vessels (recreational/commercial/military), marinas, and ports programs and the regulatory (permits/rules) and non-regulatory approaches for addressing their associated environmental impacts, such as air and water pollution.

Compliance with vessel speed restrictions to protect North Atlantic right whales.

PubMed

Silber, Gregory K; Adams, Jeffrey D; Fonnesbeck, Christopher J

2014-01-01

Environmental regulations can only be effective if they are adhered to, but the motivations for regulatory compliance are not always clear. We assessed vessel operator compliance with a December 2008 regulation aimed at reducing collisions with the endangered North Atlantic right whale that requires vessels 65 feet or greater in length to travel at speeds of 10 knots or less at prescribed times and locations along the U.S. eastern seaboard. Extensive outreach efforts were undertaken to notify affected entities both before and after the regulation went into effect. Vessel speeds of 201,862 trips made between November 2008 and August 2013 by 8,009 individual vessels were quantified remotely, constituting a nearly complete census of transits made by the regulated population. Of these, 437 vessels (or their parent companies), some of whom had been observed exceeding the speed limit, were contacted through one of four non-punitive information programs. A fraction (n = 26 vessels/companies) received citations and fines. Despite the efforts to inform mariners, initial compliance was low (<5% of the trips were completely <10 knots) but improved in the latter part of the study. Each notification/enforcement program improved compliance to some degree and some may have influenced compliance across the entire regulated community. Citations/fines appeared to have the greatest influence on improving compliance in notified vessels/companies, followed in order of effectiveness by enforcement-office information letters, monthly summaries of vessel operations, and direct at-sea radio contact. Trips by cargo vessels exhibited the greatest change in behavior followed by tanker and passenger vessels. These results have application to other regulatory systems, especially where remote monitoring is feasible, and any setting where regulatory compliance is sought.

Compliance with vessel speed restrictions to protect North Atlantic right whales

PubMed Central

Adams, Jeffrey D.; Fonnesbeck, Christopher J.

2014-01-01

Environmental regulations can only be effective if they are adhered to, but the motivations for regulatory compliance are not always clear. We assessed vessel operator compliance with a December 2008 regulation aimed at reducing collisions with the endangered North Atlantic right whale that requires vessels 65 feet or greater in length to travel at speeds of 10 knots or less at prescribed times and locations along the U.S. eastern seaboard. Extensive outreach efforts were undertaken to notify affected entities both before and after the regulation went into effect. Vessel speeds of 201,862 trips made between November 2008 and August 2013 by 8,009 individual vessels were quantified remotely, constituting a nearly complete census of transits made by the regulated population. Of these, 437 vessels (or their parent companies), some of whom had been observed exceeding the speed limit, were contacted through one of four non-punitive information programs. A fraction (n = 26 vessels/companies) received citations and fines. Despite the efforts to inform mariners, initial compliance was low (<5% of the trips were completely <10 knots) but improved in the latter part of the study. Each notification/enforcement program improved compliance to some degree and some may have influenced compliance across the entire regulated community. Citations/fines appeared to have the greatest influence on improving compliance in notified vessels/companies, followed in order of effectiveness by enforcement-office information letters, monthly summaries of vessel operations, and direct at-sea radio contact. Trips by cargo vessels exhibited the greatest change in behavior followed by tanker and passenger vessels. These results have application to other regulatory systems, especially where remote monitoring is feasible, and any setting where regulatory compliance is sought. PMID:24949229

76 FR 12982 - Policy for Guidelines for Coast Guard Evaluations of Compliance With the U.S. Environmental...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-03-09

... permitting program issued under the Clean Water Act (33 U.S.C. 1342) and provides requirements for discharges.... vessels and during Port State Control (PSC) exams on foreign vessels. The Coast Guard will report detected... inspections and exams. Vessel owners and/or operators are ultimately responsible for compliance with all...

50 CFR 622.22 - Individual fishing quota (IFQ) program for Gulf groupers and tilefishes.

Code of Federal Regulations, 2014 CFR

2014-10-01

..., but is not limited to, date, time, and location of transaction; weight and actual ex-vessel price of... fee cannot exceed 3 percent of the ex-vessel value of Gulf groupers and tilefishes landed under the... Access System Administration Fund (LASAF). Initially, the fee will be 3 percent of the actual ex-vessel...

Capital Construction Fund Program :: Office of Management and Budget

Science.gov Websites

vessels with before-tax, rather than after-tax dollars. Under the CCF Program, the amount accumulated by deferring tax on fishing income, when used to help pay for a vessel project, represents the time value of , to be applicable to any given tax year, a CCF agreement must be executed and entered on or before the

75 FR 72793 - National Saltwater Angler Registry Program

Federal Register 2010, 2011, 2012, 2013, 2014

2010-11-26

... fifteen dollars ($15.00) for registration of anglers, spear fishers and for-hire fishing vessels to... anglers, spear fishers and for-hire fishing vessels will be fifteen dollars ($15.00). All persons...

50 CFR 679.50 - Groundfish Observer Program.

Code of Federal Regulations, 2012 CFR

2012-10-01

... completion of the electronic vessel and/or processor survey(s); (B) Complete NMFS electronic vessel and/or processor surveys before performing other jobs or duties which are not part of NMFS groundfish observer...

50 CFR 679.50 - Groundfish Observer Program.

Code of Federal Regulations, 2011 CFR

2011-10-01

... completion of the electronic vessel and/or processor survey(s); (B) Complete NMFS electronic vessel and/or processor surveys before performing other jobs or duties which are not part of NMFS groundfish observer...

Reconstructing cerebrovascular networks under local physiological constraints by integer programming

DOE PAGES

Rempfler, Markus; Schneider, Matthias; Ielacqua, Giovanna D.; ...

2015-04-23

We introduce a probabilistic approach to vessel network extraction that enforces physiological constraints on the vessel structure. The method accounts for both image evidence and geometric relationships between vessels by solving an integer program, which is shown to yield the maximum a posteriori (MAP) estimate to the probabilistic model. Starting from an over-connected network, it is pruning vessel stumps and spurious connections by evaluating the local geometry and the global connectivity of the graph. We utilize a high-resolution micro computed tomography (µCT) dataset of a cerebrovascular corrosion cast to obtain a reference network and learn the prior distributions of ourmore » probabilistic model. As a result, we perform experiments on micro magnetic resonance angiography (µMRA) images of mouse brains and discuss properties of the networks obtained under different tracking and pruning approaches.« less

ASME Section VIII Recertification of a 33,000 Gallon Vacuum-jacketed LH2 Storage Vessel for Densified Hydrogen Testing at NASA Kennedy Space Center

NASA Technical Reports Server (NTRS)

Swanger, Adam M.; Notardonato, William U.; Jumper, Kevin M.

2015-01-01

The Ground Operations Demonstration Unit for Liquid Hydrogen (GODU-LH2) has been developed at NASA Kennedy Space Center in Florida. GODU-LH2 has three main objectives: zero-loss storage and transfer, liquefaction, and densification of liquid hydrogen. A cryogenic refrigerator has been integrated into an existing, previously certified, 33,000 gallon vacuum-jacketed storage vessel built by Minnesota Valley Engineering in 1991 for the Titan program. The dewar has an inner diameter of 9.5 and a length of 71.5; original design temperature and pressure ranges are -423 F to 100 F and 0 to 95 psig respectively. During densification operations the liquid temperature will be decreased below the normal boiling point by the refrigerator, and consequently the pressure inside the inner vessel will be sub-atmospheric. These new operational conditions rendered the original certification invalid, so an effort was undertaken to recertify the tank to the new pressure and temperature requirements (-12.7 to 95 psig and -433 F to 100 F respectively) per ASME Boiler and Pressure Vessel Code, Section VIII, Division 1. This paper will discuss the unique design, analysis and implementation issues encountered during the vessel recertification process.

PR-EDB: Power Reactor Embrittlement Database - Version 3

DOE Office of Scientific and Technical Information (OSTI.GOV)

Wang, Jy-An John; Subramani, Ranjit

2008-03-01

The aging and degradation of light-water reactor pressure vessels is of particular concern because of their relevance to plant integrity and the magnitude of the expected irradiation embrittlement. The radiation embrittlement of reactor pressure vessel materials depends on many factors, such as neutron fluence, flux, and energy spectrum, irradiation temperature, and preirradiation material history and chemical compositions. These factors must be considered to reliably predict pressure vessel embrittlement and to ensure the safe operation of the reactor. Large amounts of data from surveillance capsules are needed to develop a generally applicable damage prediction model that can be used for industrymore » standards and regulatory guides. Furthermore, the investigations of regulatory issues such as vessel integrity over plant life, vessel failure, and sufficiency of current codes, Standard Review Plans (SRPs), and Guides for license renewal can be greatly expedited by the use of a well-designed computerized database. The Power Reactor Embrittlement Database (PR-EDB) is such a comprehensive collection of data for U.S. designed commercial nuclear reactors. The current version of the PR-EDB lists the test results of 104 heat-affected-zone (HAZ) materials, 115 weld materials, and 141 base materials, including 103 plates, 35 forgings, and 3 correlation monitor materials that were irradiated in 321 capsules from 106 commercial power reactors. The data files are given in dBASE format and can be accessed with any personal computer using the Windows operating system. "User-friendly" utility programs have been written to investigate radiation embrittlement using this database. Utility programs allow the user to retrieve, select and manipulate specific data, display data to the screen or printer, and fit and plot Charpy impact data. The PR-EDB Version 3.0 upgrades Version 2.0. The package was developed based on the Microsoft .NET framework technology and uses Microsoft Access for backend data storage, and Microsoft Excel for plotting graphs. This software package is compatible with Windows (98 or higher) and has been built with a highly versatile user interface. PR-EDB Version 3.0 also contains an "Evaluated Residual File" utility for generating the evaluated processed files used for radiation embrittlement study.« less

Stress concentration factors for circular, reinforced penetrations in pressurized cylindrical shells. Ph.D. Thesis - Virginia Univ.

NASA Technical Reports Server (NTRS)

Ramsey, J. W., Jr.

1975-01-01

The effect on stresses in a cylindrical shell with a circular penetration subject to internal pressure was investigated in thin, shallow linearly, elastic cylindrical shells. Results provide numerical predictions of peak stress concentration factors around nonreinforced and reinforced penetrations in pressurized cylindrical shells. Analytical results were correlated with published formulas, as well as theoretical and experimental results. An accuracy study was made of the finite element program for each of the configurations considered important in pressure vessel technology. A formula is developed to predict the peak stress concentration factor for analysis and/or design in conjunction with the ASME Boiler and Pressure Vessel Code.

Fiber Breakage Model for Carbon Composite Stress Rupture Phenomenon: Theoretical Development and Applications

NASA Technical Reports Server (NTRS)

Murthy, Pappu L. N.; Phoenix, S. Leigh; Grimes-Ledesma, Lorie

2010-01-01

Stress rupture failure of Carbon Composite Overwrapped Pressure Vessels (COPVs) is of serious concern to Science Mission and Constellation programs since there are a number of COPVs on board space vehicles with stored gases under high pressure for long durations of time. It has become customary to establish the reliability of these vessels using the so called classic models. The classical models are based on Weibull statistics fitted to observed stress rupture data. These stochastic models cannot account for any additional damage due to the complex pressure-time histories characteristic of COPVs being supplied for NASA missions. In particular, it is suspected that the effects of proof test could significantly reduce the stress rupture lifetime of COPVs. The focus of this paper is to present an analytical appraisal of a model that incorporates damage due to proof test. The model examined in the current paper is based on physical mechanisms such as micromechanics based load sharing concepts coupled with creep rupture and Weibull statistics. For example, the classic model cannot accommodate for damage due to proof testing which every flight vessel undergoes. The paper compares current model to the classic model with a number of examples. In addition, several applications of the model to current ISS and Constellation program issues are also examined.

X-ray micro-computed tomography in willow reveals tissue patterning of reaction wood and delay in programmed cell death.

PubMed

Brereton, Nicholas James Beresford; Ahmed, Farah; Sykes, Daniel; Ray, Michael Jason; Shield, Ian; Karp, Angela; Murphy, Richard James

2015-03-11

Variation in the reaction wood (RW) response has been shown to be a principle component driving differences in lignocellulosic sugar yield from the bioenergy crop willow. The phenotypic cause(s) behind these differences in sugar yield, beyond their common elicitor, however, remain unclear. Here we use X-ray micro-computed tomography (μCT) to investigate RW-associated alterations in secondary xylem tissue patterning in three dimensions (3D). Major architectural alterations were successfully quantified in 3D and attributed to RW induction. Whilst the frequency of vessels was reduced in tension wood tissue (TW), the total vessel volume was significantly increased. Interestingly, a delay in programmed-cell-death (PCD) associated with TW was also clearly observed and readily quantified by μCT. The surprising degree to which the volume of vessels was increased illustrates the substantial xylem tissue remodelling involved in reaction wood formation. The remodelling suggests an important physiological compromise between structural and hydraulic architecture necessary for extensive alteration of biomass and helps to demonstrate the power of improving our perspective of cell and tissue architecture. The precise observation of xylem tissue development and quantification of the extent of delay in PCD provides a valuable and exciting insight into this bioenergy crop trait.

29 CFR Appendix V to Part 1918 - Basic Elements of a First Aid Training Program (Non-mandatory)

Code of Federal Regulations, 2011 CFR

2011-07-01

...-mandatory) V Appendix V to Part 1918 Labor Regulations Relating to Labor (Continued) OCCUPATIONAL SAFETY AND...) Side Stress on Boom .66(b)(3)(i) Vessel's Permanent Equipment .55 Visible Defects .66(b)(3)(ii) Cups... Related Employments .2 River Towboat .2 Small Trimming Hatch .2 Vessel .2 Vessel's Cargo Handling Gear .2...

29 CFR Appendix V to Part 1918 - Basic Elements of a First Aid Training Program (Non-mandatory)

Code of Federal Regulations, 2012 CFR

2012-07-01

...-mandatory) V Appendix V to Part 1918 Labor Regulations Relating to Labor (Continued) OCCUPATIONAL SAFETY AND...) Side Stress on Boom .66(b)(3)(i) Vessel's Permanent Equipment .55 Visible Defects .66(b)(3)(ii) Cups... Related Employments .2 River Towboat .2 Small Trimming Hatch .2 Vessel .2 Vessel's Cargo Handling Gear .2...

75 FR 54026 - Safety Zone; Red Bull Flugtag, Delaware River, Camden, NJ

Federal Register 2010, 2011, 2012, 2013, 2014

2010-09-03

... Franklin Bridge. The safety zone will restrict vessel traffic from a portion of the Delaware River [email protected] . If you have questions on viewing the docket, call Renee V. Wright, Program Manager... from vessels and vessels from any debris in the water as a result from the event. Under 5 U.S.C. 553(d...

76 FR 71987 - Collection of Information Under Review by Office of Management and Budget

Federal Register 2010, 2011, 2012, 2013, 2014

2011-11-21

..., Alternate Compliance Program, 1625-0083, Operational Measures for Existing Tank Vessels Without Double Hulls.... Title: Operational Measures for Existing Tank Vessels Without Double Hulls. OMB Control Number: 1625...

75 FR 16072 - Fisheries Finance Program; Final Program Notice and Announcement of Availability of Federal...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-03-31

...NMFS announces the availability of long-term direct loans made underthe Fisheries Finance Program (FFP). The FFP provides financing for the purchase of used vessels or the reconstruction of vessels (limited to reconstructions that do not add to fishing capacity); refinancing for existing debt obligations; financing or refinancing fisheries shoreside facilities or aquacultural facilities; and the purchase or refinancing of Individual Fishing Quota (IFQ) in the North Pacific. FFP loans are not issued for purposes which could contribute to over capitalization of the fishing industry.

50 CFR 660.150 - Mothership (MS) Coop Program.

Code of Federal Regulations, 2011 CFR

2011-10-01

...) Accumulation limits—(i) MS permit usage limit. No person who owns an MS permit(s) may register the MS permit(s... permit owner complies with the accumulation limits. (ii) Catcher vessel usage limit. No vessel may catch...

Research Methods to Develop Measures of Effectiveness of the United States Coast Guard’s Vessel Inspection and Boarding Program. Decision Support for Utilizing Measures of Effectiveness - Volume III

DTIC Science & Technology

1995-05-01

Eubank S.E. Albuquerque, NM 87123 Christopher Rodriguez Kevin Downer U.S. Coast Guard Research and Development Center 1082 Shennecossett Road Groton...standard, specifica )e n. ’OVVELOPj4 Commanding Officer United States Coast Guard Research & Development Center 1082 Shennecossett Road SGroton, CT...Work Unit No. (TRAIS) U.S. Coast Guard Sandia National Laboratories Research and Development Center 11. Contract or Grant No. 1515 Eubank SE 1082

Report on the FY17 Development of Computer Program for ASME Section III, Division 5, Subsection HB, Subpart B Rules

DOE Office of Scientific and Technical Information (OSTI.GOV)

Swindeman, M. J.; Jetter, R. I.; Sham, T. -L.

One of the objectives of the high temperature design methodology activities is to develop and validate both improvements and the basic features of ASME Boiler and Pressure Vessel Code, Section III, Rules for Construction of Nuclear Facility Components, Division 5, High Temperature Reactors, Subsection HB, Subpart B (HBB). The overall scope of this task is to develop a computer program to aid assessment procedures of components under specified loading conditions in accordance with the elevated temperature design requirements for Division 5 Class A components. There are many features and alternative paths of varying complexity in HBB. The initial focus ofmore » this computer program is a basic path through the various options for a single reference material, 316H stainless steel. However, the computer program is being structured for eventual incorporation all of the features and permitted materials of HBB. This report will first provide a description of the overall computer program, particular challenges in developing numerical procedures for the assessment, and an overall approach to computer program development. This is followed by a more comprehensive appendix, which is the draft computer program manual for the program development. The strain limits rules have been implemented in the computer program. The evaluation of creep-fatigue damage will be implemented in future work scope.« less

Computer Analysis of Eye Blood-Vessel Images

NASA Technical Reports Server (NTRS)

Wall, R. J.; White, B. S.

1984-01-01

Technique rapidly diagnoses diabetes mellitus. Photographs of "whites" of patients' eyes scanned by computerized image analyzer programmed to quantify density of small blood vessels in conjuctiva. Comparison with data base of known normal and diabetic patients facilitates rapid diagnosis.

The IRIS Spool-Type Reactor Coolant Pump

DOE Office of Scientific and Technical Information (OSTI.GOV)

Kujawski, J.M.; Kitch, D.M.; Conway, L.E.

2002-07-01

IRIS (International Reactor Innovative and Secure) is a light water cooled, 335 MWe power reactor which is being designed by an international consortium as part of the US DOE NERI Program. IRIS features an integral reactor vessel that contains all the major reactor coolant system components including the reactor core, the coolant pumps, the steam generators and the pressurizer. This integral design approach eliminates the large coolant loop piping, and thus eliminates large loss-of-coolant accidents (LOCAs) as well as the individual component pressure vessels and supports. In addition, IRIS is being designed with a long life core and enhanced safetymore » to address the requirements defined by the US DOE for Generation IV reactors. One of the innovative features of the IRIS design is the adoption of a reactor coolant pump (called 'spool' pump) which is completely contained inside the reactor vessel. Background, status and future developments of the IRIS spool pump are presented in this paper. (authors)« less

Education and Outreach Plans for the U.S. Drillship in IODP

NASA Astrophysics Data System (ADS)

White, K. S.; Reagan, M.; Klaus, A. D.

2003-12-01

The Integrated Ocean Drilling Program (IODP) began on October 1, 2003, following the end of operations of the 20-year Ocean Drilling Program (ODP). Education and outreach is a key component of IODP both nationally and internationally. The JOI Alliance (Joint Oceanographic Institutions, Inc., Texas A&M University, and Lamont Doherty Earth Observatory of Columbia University) will lead activities related to the U.S. drillship, coordinating these education and outreach efforts with those undertaken by the Central Management Organization, other IODP platform operators, and a U.S. Science Support Program successor. The Alliance will serve the national and assist the international scientific drilling communities by providing the results from the U.S. vessel to the public, government representatives, and scientists. The Alliance will expand upon media outreach strategies that were successful in ODP, such as issuing press releases at the conclusion of each leg and for major scientific breakthroughs; conducting tours, press conferences, and events during port calls; working with the press at major scientific meetings, and encouraging journalists to sail on expeditions. The Alliance will increase its education role by developing, coordinating, and disseminating educational materials and programs for teachers and students on the scientific themes and discoveries of IODP science. An important component of the outreach plan is using the vessel and associated laboratories and repositories as classrooms. IODP plans include multiple ship berths each year for teachers, based on the success of a pilot program conducted by ODP in 2001. This program, featuring a teacher onboard for a cruise, was accompanied by a distance-learning program and on-line curriculum models. Teachers can tour, both virtually and directly, laboratories and core repositories and participate in scheduled activities and courses. Using science conducted onboard the ship, the Alliance will develop online curriculum materials, as well as publications and fact sheets geared toward nonscientists. The Alliance will partner with existing scientific and education organizations, including programs at their universities, to widely disseminate IODP results and materials.

50 CFR 679.92 - Amendment 80 Program use caps and sideboard limits.

Code of Federal Regulations, 2011 CFR

2011-10-01

... not apply when an Amendment 80 vessel is using dredge gear while directed fishing for scallops in the... apply when an Amendment 80 vessel is using dredge gear while directed fishing for scallops in the GOA...

Development and origins of zebrafish ocular vasculature.

PubMed

Kaufman, Rivka; Weiss, Omri; Sebbagh, Meyrav; Ravid, Revital; Gibbs-Bar, Liron; Yaniv, Karina; Inbal, Adi

2015-03-27

The developing eye receives blood supply from two vascular systems, the intraocular hyaloid system and the superficial choroidal vessels. In zebrafish, a highly stereotypic and simple set of vessels develops on the surface of the eye prior to development of choroidal vessels. The origins and formation of this so-called superficial system have not been described. We have analyzed the development of superficial vessels by time-lapse imaging and identified their origins by photoconversion experiments in kdrl:Kaede transgenic embryos. We show that the entire superficial system is derived from a venous origin, and surprisingly, we find that the hyaloid system has, in addition to its previously described arterial origin, a venous origin for specific vessels. Despite arising solely from a vein, one of the vessels in the superficial system, the nasal radial vessel (NRV), appears to acquire an arterial identity while growing over the nasal aspect of the eye and this happens in a blood flow-independent manner. Our results provide a thorough analysis of the early development and origins of zebrafish ocular vessels and establish the superficial vasculature as a model for studying vascular patterning in the context of the developing eye.

New insights into saccular development and vascular formation in lung allografts under the renal capsule

PubMed Central

Vu, Thiennu H.; Alemayehu, Yemisrach; Werb, Zena

2009-01-01

The study of distal lung morphogenesis and vascular development would be greatly facilitated by an in vitro or ex vivo experimental model. In this study we show that the growth of mouse embryonic day 12.5 lung rudiments implanted underneath the kidney capsules of syngeneic or immunodeficient hosts follows closely lung development in utero. The epithelium develops extensively with both proximal and distal differentiation to the saccular stage. The vasculature also develops extensively. Large blood vessels accompany large airways and capillaries develop within the saccular walls. Interestingly, vessels in the lung grafts develop from endothelial progenitor cells endogenous to the explants and host vessels do not vascularize the grafts independently. This suggests that embryonic lungs possess mechanisms to prevent the inappropriate ingrowth of surrounding vessels. However, vessels in the lung grafts do connect to host vessels, showing that embryonic lungs have the ability to stimulate host angiogenesis and recruit host vessel connections. These data support the hypothesis that the lung vasculature develops by both vasculogenic and angiogenic processes: a vascular network develops in situ in lung mesenchyme, which is then connected to angiogenic processes from central vessels. The lung renal capsule allograft is thus an excellent model to study the development of the pulmonary vasculature and of late fetal lung development that requires a functional blood supply. PMID:12591600

77 FR 59852 - Fisheries of the Exclusive Economic Zone Off Alaska; Bering Sea and Aleutian Islands Management...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-10-01

...NMFS publishes regulations to implement Amendment 97 to the Fishery Management Plan for Groundfish of the Bering Sea and Aleutian Islands Management Area (FMP). Amendment 97 allows the owner of a trawl catcher/processor vessel authorized to participate in the Amendment 80 catch share program to replace that vessel with a vessel that meets certain requirements. This action establishes the regulatory process for replacement of vessels in the Amendment 80 fleet and the requirements for Amendment 80 replacement vessels, such as a limit on the overall length of a replacement vessel, a prohibition on the use of an AFA vessel as a replacement vessel, measures to prevent a replaced vessel from participating in Federal groundfish fisheries off Alaska that are not Amendment 80 fisheries, and measures that extend specific catch limits (known as Amendment 80 sideboards) to a replacement vessel. This action is necessary to promote safety-at-sea by allowing Amendment 80 vessel owners to replace their vessels for any reason at any time and by requiring replacement vessels to meet certain U.S. Coast Guard vessel safety standards, and to improve the retention and utilization of groundfish catch by these vessels by facilitating an increase in the processing capabilities of the fleet. This action is intended to promote the goals and objectives of the Magnuson-Stevens Fishery Conservation and Management Act, the FMP, and other applicable laws.

Individual Pressure Vessel (PV) and Common Pressure Vessel (CPV) Nickel-Hydrogen Battery Performance Under LEO Cycling Conditions

NASA Technical Reports Server (NTRS)

Miller, Thomas B.; Lewis, Harlan L.

2004-01-01

LEO life cycle testing of Individual Pressure Vessel (PV) and Common Pressure Vessel (CPV) nickel-hydrogen cell packs have been sponsored by the NASA Aerospace Flight Battery Program. The cell packs have cycled under both 35% and 60% depth-of- discharge and temperature conditions of -5 C and +lO C. The packs have been on test since as early as 1992 and have generated a substantial database. This report will provide insight into performance trends as a function of the specific cell configuration and manufacturer for eight separate nickel-hydrogen battery cell packs.

Vessel V-7 and V-8 repair and characterization of insert material. Final report

DOE Office of Scientific and Technical Information (OSTI.GOV)

Domian, H.A.

1984-05-01

Pieces of Type SA508-2 steel, specially tempered to produce a high-impact-transition temperature, were welded in the side walls of Intermediate Test Vessels V-7 and V-8. These vessels are to be tested by the Oak Ridge National Laboratory (ORNL) in the Pressurized-Thermal-Shock (PTS) Project of the Heavy-Section Steel Technology (HSST) Program. A comparable piece of forging taken from the same source and heat treated with the vessels was characterized for its mechanical properties to provide data for use in the PTS tests.

SAMOS Surface Fluxes

NASA Astrophysics Data System (ADS)

Smith, Shawn; Bourassa, Mark

2014-05-01

The development of a new surface flux dataset based on underway meteorological observations from research vessels will be presented. The research vessel data center at the Florida State University routinely acquires, quality controls, and distributes underway surface meteorological and oceanographic observations from over 30 oceanographic vessels. These activities are coordinated by the Shipboard Automated Meteorological and Oceanographic System (SAMOS) initiative in partnership with the Rolling Deck to Repository (R2R) project. Recently, the SAMOS data center has used these underway observations to produce bulk flux estimates for each vessel along individual cruise tracks. A description of this new flux product, along with the underlying data quality control procedures applied to SAMOS observations, will be provided. Research vessels provide underway observations at high-temporal frequency (1 min. sampling interval) that include navigational (position, course, heading, and speed), meteorological (air temperature, humidity, wind, surface pressure, radiation, rainfall), and oceanographic (surface sea temperature and salinity) samples. Vessels recruited to the SAMOS initiative collect a high concentration of data within the U.S. continental shelf and also frequently operate well outside routine shipping lanes, capturing observations in extreme ocean environments (Southern, Arctic, South Atlantic, and South Pacific oceans). These observations are atypical for their spatial and temporal sampling, making them very useful for many applications including validation of numerical models and satellite retrievals, as well as local assessments of natural variability. Individual SAMOS observations undergo routine automated quality control and select vessels receive detailed visual data quality inspection. The result is a quality-flagged data set that is ideal for calculating turbulent flux estimates. We will describe the bulk flux algorithms that have been applied to the observations and the choices of constants that are used. Analysis of the preliminary SAMOS flux products will be presented, including spatial and temporal coverage for each derived parameter. The unique quality and sampling locations of research vessel observations and their independence from many models and products makes them ideal for validation studies. The strengths and limitations of research observations for flux validation studies will be discussed. The authors welcome a discussion with the flux community regarding expansion of the SAMOS program to include additional international vessels, thus facilitating and expansion of this research vessel-based flux product.

Port Needs Study (Vessel Traffic Services Benefits) Volume 1: Study Report

DOT National Transportation Integrated Search

1991-08-01

This study documents the benefits and costs of potential U.S. Coast Guard Vessel Traffic Services (VTS) in selected U.S. deep draft ports on the Atlantic, Gulf and Pacific Coasts. The U.S. Department of Transportation's Research and Special Programs ...

USCG Pollution Abatement Program : A Preliminary Study of Vessel and Boat Exhaust Emissions

DOT National Transportation Integrated Search

1971-11-30

A preliminary study of exhaust emissions from Coast Guard vessels and boats indicates that the Coast Guard fleet is an insignificant contributor to air pollution on a national and regional basis. Based upon fuel usage data, emission estimates by vess...

40 CFR 60.271a - Definitions.

Code of Federal Regulations, 2010 CFR

2010-07-01

... the top of an AOD vessel. Control device means the air pollution control equipment used to remove... vessel to the air pollution control device. Charge means the addition of iron and steel scrap or other... Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR PROGRAMS (CONTINUED) STANDARDS OF...

40 CFR 60.271a - Definitions.

Code of Federal Regulations, 2011 CFR

2011-07-01

... the top of an AOD vessel. Control device means the air pollution control equipment used to remove... vessel to the air pollution control device. Charge means the addition of iron and steel scrap or other... Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR PROGRAMS (CONTINUED) STANDARDS OF...

40 CFR 60.271a - Definitions.

Code of Federal Regulations, 2013 CFR

2013-07-01

... the top of an AOD vessel. Control device means the air pollution control equipment used to remove... vessel to the air pollution control device. Charge means the addition of iron and steel scrap or other... Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR PROGRAMS (CONTINUED) STANDARDS OF...

40 CFR 60.271a - Definitions.

Code of Federal Regulations, 2012 CFR

2012-07-01

... the top of an AOD vessel. Control device means the air pollution control equipment used to remove... vessel to the air pollution control device. Charge means the addition of iron and steel scrap or other... Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR PROGRAMS (CONTINUED) STANDARDS OF...

40 CFR 60.271a - Definitions.

Code of Federal Regulations, 2014 CFR

2014-07-01

... the top of an AOD vessel. Control device means the air pollution control equipment used to remove... vessel to the air pollution control device. Charge means the addition of iron and steel scrap or other... Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR PROGRAMS (CONTINUED) STANDARDS OF...

75 FR 56015 - Vessel Inspection Alternatives

Federal Register 2010, 2011, 2012, 2013, 2014

2010-09-15

... page 88, in Sec. 8.420, paragraph (c) is revised to read as follows: Sec. 8.420 Classification society authorization to participate in the Alternate Compliance Program. * * * * * (c) A recognized classification... (2) Must have performed a delegated function related to general vessel safety assessment, as defined...

40 CFR 140.2 - Scope of standard.

Code of Federal Regulations, 2010 CFR

2010-07-01

... Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) WATER PROGRAMS (CONTINUED) MARINE... which a marine sanitation device has been installed. The standard does not require the installation of a marine sanitation device on any vessel that is not so equipped. The standard applies to vessels owned and...

Methods and Systems for Configuring Sensor Acquisition Based on Pressure Steps

NASA Technical Reports Server (NTRS)

DeDonato, Mathew (Inventor)

2015-01-01

Technologies are provided for underwater measurements. A system includes an underwater vessels including: a plurality of sensors disposed thereon for measuring underwater properties; and a programmable controller configured to selectively activate the plurality of sensors based at least in part on underwater pressure. A user may program at what pressure ranges certain sensors are activated to measure selected properties, and may also program the ascent/descent rate of the underwater vessel, which is correlated with the underwater pressure.

Navy LPD-17 Amphibious Ship Procurement: Background, Issues, and Options for Congress

DTIC Science & Technology

2010-08-02

and Options for Congress 5a. CONTRACT NUMBER 5b. GRANT NUMBER 5c. PROGRAM ELEMENT NUMBER 6. AUTHOR(S) 5d. PROJECT NUMBER 5e . TASK NUMBER 5f...has been required, disrupting the optimal construction sequence and application of lessons learned for follow-on vessels in these programs... NGSS ) ability to recover in the aftermath of Hurricane Katrina, particularly in regard to construction of LPD 17 Class vessels.” • “I am equally

Navy LPD-17 Amphibious Ship Procurement: Background, Issues, and Options for Congress

DTIC Science & Technology

2010-07-07

and Options for Congress 5a. CONTRACT NUMBER 5b. GRANT NUMBER 5c. PROGRAM ELEMENT NUMBER 6. AUTHOR(S) 5d. PROJECT NUMBER 5e . TASK NUMBER 5f...has been required, disrupting the optimal construction sequence and application of lessons learned for follow-on vessels in these programs... NGSS ) ability to recover in the aftermath of Hurricane Katrina, particularly in regard to construction of LPD 17 Class vessels.” • “I am equally

Navy LPD-17 Amphibious Ship Procurement: Background, Issues, and Options for Congress

DTIC Science & Technology

2010-10-04

Issues, and Options for Congress 5a. CONTRACT NUMBER 5b. GRANT NUMBER 5c. PROGRAM ELEMENT NUMBER 6. AUTHOR(S) 5d. PROJECT NUMBER 5e . TASK NUMBER 5f...rework has been required, disrupting the optimal construction sequence and application of lessons learned for follow-on vessels in these programs...Systems’ ( NGSS ) ability to recover in the aftermath of Hurricane Katrina, particularly in regard to construction of LPD 17 Class vessels.” • “I am

Tracking Vessels to Illegal Pollutant Discharges Using Multisource Vessel Information

NASA Astrophysics Data System (ADS)

Busler, J.; Wehn, H.; Woodhouse, L.

2015-04-01

Illegal discharge of bilge waters is a significant source of oil and other environmental pollutants in Canadian and international waters. Imaging satellites are commonly used to monitor large areas to detect oily discharges from vessels, off-shore platforms and other sources. While remotely sensed imagery provides a snap-shot picture useful for detecting a spill or the presence of vessels in the vicinity, it is difficult to directly associate a vessel to an observed spill unless the vessel is observed while the discharge is occurring. The situation then becomes more challenging with increased vessel traffic as multiple vessels may be associated with a spill event. By combining multiple sources of vessel location data, such as Automated Information Systems (AIS), Long Range Identification and Tracking (LRIT) and SAR-based ship detection, with spill detections and drift models we have created a system that associates detected spill events with vessels in the area using a probabilistic model that intersects vessel tracks and spill drift trajectories in both time and space. Working with the Canadian Space Agency and the Canadian Ice Service's Integrated Satellite Tracking of Pollution (ISTOP) program, we use spills observed in Canadian waters to demonstrate the investigative value of augmenting spill detections with temporally sequenced vessel and spill tracking information.

A novel reverse-osmosis wash water recycle system for manned space stations

NASA Technical Reports Server (NTRS)

Ray, R. J.; Babcock, W. C.; Barss, R. P.; Andrews, T. A.; Lachapelle, E. D.

1984-01-01

The preliminary development of a wash water recycle system utilizing an inside-skinned hollow-fiber membrane is described. This module configuration is based on tube-side feed and is highly resistant to fouling with a minimum of pretreatment. During an ongoing research program for NASA, these modules were operated on actual wash waters with no significant fouling for a period of 40 days. Due to the tube-side-feed flow in these hollow-fiber membranes, the fibers themselves become the pressure vessels, allowing the development of extremely lightweight membrane modules. During the NASA research program, a pre-prototype membrane module capable of processing 6 gallons per day of wash water at 97 percent recovery was developed that can be dry-stored and that weighs 120 g.

Fusion Materials Semiannual Progress Report for Period Ending December 31, 1998

DOE Office of Scientific and Technical Information (OSTI.GOV)

Rowcliff, A.F.; Burn, G.

1999-04-01

This is the twenty-fifth in a series of semiannual technical progress reports on fusion materials. This report combines the full spectrum of research and development activities on both metallic and non-metallic materials with primary emphasis on the effects of the neutronic and chemical environment on the properties and performance of materials for in-vessel components. This effort forms one element of the materials program being conducted in support of the Fusion Energy Sciences Program of the U.S. Department of Energy. The other major element of the program is concerned with the interactions between reactor materials and the plasma and is reportedmore » separately.« less

Inland Waterway Environmental Safety

NASA Astrophysics Data System (ADS)

Reshnyak, Valery; Sokolov, Sergey; Nyrkov, Anatoliy; Budnik, Vlad

2018-05-01

The article presents the results of development of the main components of the environmental safety when operating vessels on inland waterways, which include strategy selection ensuring the environmental safety of vessels, the selection and justification of a complex of environmental technical means, activities to ensure operation of vessels taking into account the environmental technical means. Measures to ensure environmental safety are developed on the basis of the principles aimed at ensuring environmental safety of vessels. They include the development of strategies for the use of environmental protection equipment, which are determined by the conditions for wastewater treatment of purified sewage and oily bilge water as well as technical characteristics of the vessels, the introduction of the process of the out-of-the-vessel processing of ship pollution as a technology for their movement. This must take into account the operating conditions of vessels on different sections of waterways. An algorithm of actions aimed at ensuring ecological safety of operated vessels is proposed.

Development of technology for creating intelligent control systems for power plants and propulsion systems for marine robotic systems

NASA Astrophysics Data System (ADS)

Iakovleva, E. V.; Momot, B. A.

2017-10-01

The object of this study is to develop a power plant and an electric propulsion control system for autonomous remotely controlled vessels. The tasks of the study are as follows: to assess remotely controlled vessels usage reasonability, to define the requirements for this type of vessel navigation. In addition, the paper presents the analysis of technical diagnostics systems. The developed electric propulsion control systems for vessels should provide improved reliability and efficiency of the propulsion complex to ensure the profitability of remotely controlled vessels.

33 CFR 157.430 - Enhanced survey requirements.

Code of Federal Regulations, 2011 CFR

2011-07-01

... 33 Navigation and Navigable Waters 2 2011-07-01 2011-07-01 false Enhanced survey requirements. 157... § 157.430 Enhanced survey requirements. Beginning at each tank vessel's next regularly scheduled drydock... tank vessel owner or operator shall— (a) Implement an enhanced survey program that complies with the...

33 CFR 157.430 - Enhanced survey requirements.

Code of Federal Regulations, 2012 CFR

2012-07-01

... 33 Navigation and Navigable Waters 2 2012-07-01 2012-07-01 false Enhanced survey requirements. 157... § 157.430 Enhanced survey requirements. Beginning at each tank vessel's next regularly scheduled drydock... tank vessel owner or operator shall— (a) Implement an enhanced survey program that complies with the...

33 CFR 157.430 - Enhanced survey requirements.

Code of Federal Regulations, 2014 CFR

2014-07-01

... 33 Navigation and Navigable Waters 2 2014-07-01 2014-07-01 false Enhanced survey requirements. 157... § 157.430 Enhanced survey requirements. Beginning at each tank vessel's next regularly scheduled drydock... tank vessel owner or operator shall— (a) Implement an enhanced survey program that complies with the...

33 CFR 157.430 - Enhanced survey requirements.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 33 Navigation and Navigable Waters 2 2010-07-01 2010-07-01 false Enhanced survey requirements. 157... § 157.430 Enhanced survey requirements. Beginning at each tank vessel's next regularly scheduled drydock... tank vessel owner or operator shall— (a) Implement an enhanced survey program that complies with the...

33 CFR 157.430 - Enhanced survey requirements.

Code of Federal Regulations, 2013 CFR

2013-07-01

... 33 Navigation and Navigable Waters 2 2013-07-01 2013-07-01 false Enhanced survey requirements. 157... § 157.430 Enhanced survey requirements. Beginning at each tank vessel's next regularly scheduled drydock... tank vessel owner or operator shall— (a) Implement an enhanced survey program that complies with the...

46 CFR 30.30-9 - Evaluation.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 46 Shipping 1 2010-10-01 2010-10-01 false Evaluation. 30.30-9 Section 30.30-9 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY TANK VESSELS GENERAL PROVISIONS Interim Procedures for Evaluating Vessel Personnel Licensing and Certification Programs of Foreign Countries § 30.30-9 Evaluation. Materials...

40 CFR 94.203 - Application for certification.

Code of Federal Regulations, 2010 CFR

2010-07-01

... Section 94.203 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR PROGRAMS... § 94.109(d) for Category 3 engines. Small-volume manufacturers may omit measurement and reporting of... application of the engine (e.g., used to propel planing vessels, use to propel vessels with variable-pitch...

46 CFR 4.03-40 - Public vessels.

Code of Federal Regulations, 2010 CFR

2010-10-01

... INVESTIGATIONS Definitions § 4.03-40 Public vessels. Public vessel means a vessel that— (a) Is owned, or demise... Department (except a vessel operated by the Coast Guard or Saint Lawrence Seaway Development Corporation...

Navigational and vessel inspection circular No. 5-86. Voluntary standards for US uninspected commercial fishing vessels. Final report

DOE Office of Scientific and Technical Information (OSTI.GOV)

NONE

1986-08-18

The vessel standards program, which this NVIC addresses, originally consisted of a series of five NVICs; Stability (5-85), Radio and Shipboard Navigation Equipment (6-85), Fire Safety Measures (7-85), Lifesaving Equipment and Protection of the Crew (8-85), and Hull, Machinery, and Electrical Installations (9-85). Many of these NVICs contained specific operational and educational material for fishermen which could be used before the `Vessel Safety Manual` was published; therefore, some material previously contained in any one of the NVICs has been moved to the manual, although some overlap still exists. Since input from the fishing industry and other interested parties was essential,more » the authors published NVICs 5-85 thru 9-85 as proposed standards and distributed them to over 230 individuals, groups and organizations throuoghout the U.S. who have an interest in fishing vessel safety. These groups included safety consultants, marine surveyors, naval architects, insurance underwriters, fishing vessel owners` associations, boat builders, fisheries unions, personnel associated with the National Oceanic and Atmospheric Administration Sea Grant program, and the National Marine Fisheries Service. Several sent detailed comments; all expressed a favorable reaction to the standards. This report is a consolidation of NVICs 5-85 thru 9-85 taking into account the comments and recommendations received. For continuity, certain regulatory requirements (although not voluntary) have been included where appropriate.« less

Fusion materials semiannual progress report for the period ending June 30, 1998

DOE Office of Scientific and Technical Information (OSTI.GOV)

Burn, G.

1998-09-01

This is the twenty-fourth in a series of semiannual technical progress reports on fusion materials. This report combines the full spectrum of research and development activities on both metallic and non-metallic materials with primary emphasis on the effects of the neutronic and chemical environment on the properties and performance of materials for in-vessel components. This effort forms one element of the materials program being conducted in support of the Fusion Energy Sciences Program of the US Department of Energy. Selected papers have been indexed separately for inclusion in the Energy Science and Technology Database.

A functional requirement for astroglia in promoting blood vessel development in the early postnatal brain.

PubMed

Ma, Shang; Kwon, Hyo Jun; Huang, Zhen

2012-01-01

Astroglia are a major cell type in the brain and play a key role in many aspects of brain development and function. In the adult brain, astrocytes are known to intimately ensheath blood vessels and actively coordinate local neural activity and blood flow. During development of the neural retina, blood vessel growth follows a meshwork of astrocytic processes. Several genes have also been implicated in retinal astrocytes for regulating vessel development. This suggests a role of astrocytes in promoting angiogenesis throughout the central nervous system. To determine the roles that astrocytes may play during brain angiogenesis, we employ genetic approaches to inhibit astrogliogenesis during perinatal corticogenesis and examine its effects on brain vessel development. We find that conditional deletion from glial progenitors of orc3, a gene required for DNA replication, dramatically reduces glial progenitor cell number in the subventricular zone and astrocytes in the early postnatal cerebral cortex. This, in turn, results in severe reductions in both the density and branching frequency of cortical blood vessels. Consistent with a delayed growth but not regression of vessels, we find neither significant net decreases in vessel density between different stages after normalizing for cortical expansion nor obvious apoptosis of endothelial cells in these mutants. Furthermore, concomitant with loss of astroglial interactions, we find increased endothelial cell proliferation, enlarged vessel luminal size as well as enhanced cytoskeletal gene expression in pericytes, which suggests compensatory changes in vascular cells. Lastly, we find that blood vessel morphology in mutant cortices recovers substantially at later stages, following astrogliosis. These results thus implicate a functional requirement for astroglia in promoting blood vessel growth during brain development.

Analysis of dpa rates in the HFIR reactor vessel using a hybrid Monte Carlo/deterministic method

DOE Office of Scientific and Technical Information (OSTI.GOV)

Blakeman, Edward

2016-01-01

The Oak Ridge High Flux Isotope Reactor (HFIR), which began full-power operation in 1966, provides one of the highest steady-state neutron flux levels of any research reactor in the world. An ongoing vessel integrity analysis program to assess radiation-induced embrittlement of the HFIR reactor vessel requires the calculation of neutron and gamma displacements per atom (dpa), particularly at locations near the beam tube nozzles, where radiation streaming effects are most pronounced. In this study we apply the Forward-Weighted Consistent Adjoint Driven Importance Sampling (FW-CADIS) technique in the ADVANTG code to develop variance reduction parameters for use in the MCNP radiationmore » transport code. We initially evaluated dpa rates for dosimetry capsule locations, regions in the vicinity of the HB-2 beamline, and the vessel beltline region. We then extended the study to provide dpa rate maps using three-dimensional cylindrical mesh tallies that extend from approximately 12 below to approximately 12 above the axial extent of the core. The mesh tally structures contain over 15,000 mesh cells, providing a detailed spatial map of neutron and photon dpa rates at all locations of interest. Relative errors in the mesh tally cells are typically less than 1%.« less

Automatic telangiectasia analysis in dermoscopy images using adaptive critic design.

PubMed

Cheng, B; Stanley, R J; Stoecker, W V; Hinton, K

2012-11-01

Telangiectasia, tiny skin vessels, are important dermoscopy structures used to discriminate basal cell carcinoma (BCC) from benign skin lesions. This research builds off of previously developed image analysis techniques to identify vessels automatically to discriminate benign lesions from BCCs. A biologically inspired reinforcement learning approach is investigated in an adaptive critic design framework to apply action-dependent heuristic dynamic programming (ADHDP) for discrimination based on computed features using different skin lesion contrast variations to promote the discrimination process. Lesion discrimination results for ADHDP are compared with multilayer perception backpropagation artificial neural networks. This study uses a data set of 498 dermoscopy skin lesion images of 263 BCCs and 226 competitive benign images as the input sets. This data set is extended from previous research [Cheng et al., Skin Research and Technology, 2011, 17: 278]. Experimental results yielded a diagnostic accuracy as high as 84.6% using the ADHDP approach, providing an 8.03% improvement over a standard multilayer perception method. We have chosen BCC detection rather than vessel detection as the endpoint. Although vessel detection is inherently easier, BCC detection has potential direct clinical applications. Small BCCs are detectable early by dermoscopy and potentially detectable by the automated methods described in this research. © 2011 John Wiley & Sons A/S.

LWR pressure vessel surveillance dosimetry improvement program: LWR power reactor surveillance physics-dosimetry data base compendium

DOE Office of Scientific and Technical Information (OSTI.GOV)

McElroy, W.N.

1985-08-01

This NRC physics-dosimetry compendium is a collation of information and data developed from available research and commercial light water reactor vessel surveillance program (RVSP) documents and related surveillance capsule reports. The data represents the results of the HEDL least-squares FERRET-SAND II Code re-evaluation of exposure units and values for 47 PWR and BWR surveillance capsules for W, B and W, CE, and GE power plants. Using a consistent set of auxiliary data and dosimetry-adjusted reactor physics results, the revised fluence values for E > 1 MeV averaged 25% higher than the originally reported values. The range of fluence values (new/old)more » was from a low of 0.80 to a high of 2.38. These HEDL-derived FERRET-SAND II exposure parameter values are being used for NRC-supported HEDL and other PWR and BWR trend curve data development and testing studies. These studies are providing results to support Revision 2 of Regulatory Guide 1.99. As stated by Randall (Ra84), the Guide is being updated to reflect recent studies of the physical basis for neutron radiation damage and efforts to correlate damage to chemical composition and fluence.« less

Engineering of functional, perfusable 3D microvascular networks on a chip.

PubMed

Kim, Sudong; Lee, Hyunjae; Chung, Minhwan; Jeon, Noo Li

2013-04-21

Generating perfusable 3D microvessels in vitro is an important goal for tissue engineering, as well as for reliable modelling of blood vessel function. To date, in vitro blood vessel models have not been able to accurately reproduce the dynamics and responses of endothelial cells to grow perfusable and functional 3D vascular networks. Here we describe a microfluidic-based platform whereby we model natural cellular programs found during normal development and angiogenesis to form perfusable networks of intact 3D microvessels as well as tumor vasculatures based on the spatially controlled co-culture of endothelial cells with stromal fibroblasts, pericytes or cancer cells. The microvessels possess the characteristic morphological and biochemical markers of in vivo blood vessels, and exhibit strong barrier function and long-term stability. An open, unobstructed microvasculature allows the delivery of nutrients, chemical compounds, biomolecules and cell suspensions, as well as flow-induced mechanical stimuli into the luminal space of the endothelium, and exhibits faithful responses to physiological shear stress as demonstrated by cytoskeleton rearrangement and increased nitric oxide synthesis. This simple and versatile platform provides a wide range of applications in vascular physiology studies as well as in developing vascularized organ-on-a-chip and human disease models for pharmaceutical screening.

40 CFR 1045.625 - What requirements apply under the Diurnal Transition Program?

Code of Federal Regulations, 2010 CFR

2010-07-01

... in this section only if you have primary responsibility for designing and manufacturing vessels and your manufacturing procedures include installing some engines in these vessels. Consider all U.S... under this section: (1) Percent-of-production allowances. You may produce up to 50 percent of your...

50 CFR 660.16 - Groundfish observer program.

Code of Federal Regulations, 2010 CFR

2010-10-01

... must not disclose collected data and observations made on board the vessel or in the processing facility to any person except the owner or operator of the observed vessel or processing facility, an... activities that would reflect negatively on their image as professional scientists, on other observers, or on...

50 CFR 679.93 - Amendment 80 Program recordkeeping, permits, monitoring, and catch accounting.

Code of Federal Regulations, 2012 CFR

2012-10-01

... CONSERVATION AND MANAGEMENT, NATIONAL OCEANIC AND ATMOSPHERIC ADMINISTRATION, DEPARTMENT OF COMMERCE (CONTINUED... storage. There is sufficient space to accommodate a minimum of 10 observer sampling baskets. This space... manager, and any observers assigned to the vessel. (8) Belt and flow operations. The vessel operator stops...

75 FR 39724 - Reports, Forms and Recordkeeping Requirements; Agency Information Collection Activity Under OMB...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-07-12

... INFORMATION: Maritime Administration (MARAD). Title: Approval of Underwriters for Marine Hull Insurance. OMB... of information involves the approval of marine hull underwriters to insure MARAD program vessels... suitability for providing marine hull insurance on MARAD vessels. Annual Estimated Burden Hours: 46 hours...

46 CFR 8.440 - Vessel enrollment in the Alternate Compliance Program.

Code of Federal Regulations, 2010 CFR

2010-10-01

... issuance or renewal of a COI may submit the vessel for classification, plan review and inspection by a recognized classification society authorized by the Coast Guard to determine compliance with applicable international treaties and agreements, the classification society's class rules, and the U.S. Supplement...

46 CFR 8.440 - Vessel enrollment in the Alternate Compliance Program.

Code of Federal Regulations, 2011 CFR

2011-10-01

... issuance or renewal of a COI may submit the vessel for classification, plan review and inspection by a recognized classification society authorized by the Coast Guard to determine compliance with applicable international treaties and agreements, the classification society's class rules, and the U.S. Supplement...

76 FR 52319 - Taking and Importing of Marine Mammals

Federal Register 2010, 2011, 2012, 2013, 2014

2011-08-22

... International Dolphin Conservation Program (IDCP) by Spanish-flag purse seine vessels or purse seine vessels operating under Spanish jurisdiction to be imported into the United States. The affirmative finding was... States of yellowfin tuna and products derived from yellowfin tuna harvested in the ETP by Spanish-flag...

LANL Robotic Vessel Scanning

DOE Office of Scientific and Technical Information (OSTI.GOV)

Webber, Nels W.

Los Alamos National Laboratory in J-1 DARHT Operations Group uses 6ft spherical vessels to contain hazardous materials produced in a hydrodynamic experiment. These contaminated vessels must be analyzed by means of a worker entering the vessel to locate, measure, and document every penetration mark on the vessel. If the worker can be replaced by a highly automated robotic system with a high precision scanner, it will eliminate the risks to the worker and provide management with an accurate 3D model of the vessel presenting the existing damage with the flexibility to manipulate the model for better and more in-depth assessment.Themore » project was successful in meeting the primary goal of installing an automated system which scanned a 6ft vessel with an elapsed time of 45 minutes. This robotic system reduces the total time for the original scope of work by 75 minutes and results in excellent data accumulation and transmission to the 3D model imaging program.« less

FINAL DESIGN REVIEW REPORT Subcritical Experiments Gen 2, 3-ft Confinement Vessel Weldment

DOE Office of Scientific and Technical Information (OSTI.GOV)

Romero, Christopher

A Final Design Review (FDR) of the Subcritical Experiments (SCE) Gen 2, 3-ft. Confinement Vessel Weldment was held at Los Alamos National Laboratory (LANL) on September 14, 2017. The review was a focused review on changes only to the confinement vessel weldment (versus a system design review). The changes resulted from lessons-learned in fabricating and inspecting the current set of confinement vessels used for the SCE Program. The baseline 3-ft. confinement vessel weldment design has successfully been used (to date) for three (3) high explosive (HE) over-tests, two (2) fragment tests, and five (5) integral HE experiments. The design teammore » applied lessons learned from fabrication and inspection of these vessel weldments to enhance fit-up, weldability, inspection, and fitness for service evaluations. The review team consisted of five (5) independent subject matter experts with engineering design, analysis, testing, fabrication, and inspection experience. The« less

The continuous plankton recorder survey: A long-term, basin-scale oceanic time series

NASA Technical Reports Server (NTRS)

Gamble, John C.; Hunt, Harold G.

1992-01-01

In the 1920s, before the advent of echo sounders, fishery biologists were greatly concerned with assisting the fisherman to locate schools of pelagic fish. One of the approaches they developed was to relate the distribution of the planktonic food organisms to the presence of the schools of predators such as herring (Clupea harengus). The British planktologist, Alister Hardy, who had already carried out extensive studies on the feeding preferences of herring (Hardy, 1926a), initiated a program to examine the fishermen's contention that herring schools avoided 'green', i.e., phytoplankton-rich, water but could be correlated with high concentrations of zooplankton. This practical program was centered on the use of a specially developed instrument, the 'Plankton Indicator', designed to be used by the fisherman to assist in the search for suitable waters. It had limited success in its main aim but, as a collecting device, it embodied several profoundly important features. It was a simple instrument which was robust enough to be deployed and recovered by the crew of commercial vessels (in this case fishing vessels) while they were underway. The Indicator however, was no more than a high speed net which integrated the plankton over the area of sampling, but Hardy had also become interested in describing the patchiness of planktonic populations. He thus developed the Continuous Plankton Recorder (CPR) where he substituted the fixed filter screen of the Indicator by a continually moving length of silk mesh. The screen traversed at constant speed across the path of the incoming water and the trapped organisms were retained in place by sandwiching beneath an additional second mesh screen. Thus, knowing the speed of the towing vessel and the shooting and hauling positions, the spatial patterns of the plankton could be determined. Hardy took the first CPR to the Antarctic where he used it in the Southern Atlantic (Hardy, 1926b) and later deployed it in the North Sea to make some of the earliest contiguous records of plankton patchiness.

Fracture resistance of welded thick-walled high-pressure vessels in power plants. Report No. 2. Approach to evaluating static strength

DOE Office of Scientific and Technical Information (OSTI.GOV)

Gorynin, I.V.; Filatov, V.M.; Ignatov, V.A.

1986-07-01

The authors examine data on the effect of defects on the fracture resistance of high-pressure vessels and their models obtained within the framework of the HSST program. Results of internal-pressure tests of two types of vessels with a wall thickness of 152 mm made from forgings of steels SA508 and SA533, as well as small vessels with a wall thickness of 11.5 and 23mm made of steel SA533 are shown. The authors state that testing thick-walled welded high-pressure vessels and thin-walled vessels with surface defects of different sizes has demonstrated that there are substantial static-strength reserves in structures designed bymore » existing domestic and foreign standards on the strength of power-plant equipment. A correction was proposed for the presently used method of calculating the resistance of highpressure vessels to brittle fracture that allows for the dimensions of the defects in relation to the type of vessel, the manufacturing technology, and the method of inspection.« less

Secondary Impacts on Structures on the Lunar Surface

NASA Technical Reports Server (NTRS)

Christiansen, Eric; Walker, James D.; Grosch, Donald J.

2010-01-01

The Altair Lunar Lander is being designed for the planned return to the Moon by 2020. Since it is hoped that lander components will be re-used by later missions, studies are underway to examine the exposure threat to the lander sitting on the Lunar surface for extended periods. These threats involve both direct strikes of meteoroids on the vehicle as well as strikes from Lunar regolith and rock thrown by nearby meteorite strikes. Currently, the lander design is comprised of up to 10 different types of pressure vessels. These vessels included the manned habitation module, fuel, cryogenic fuel and gas storage containers, and instrument bays. These pressure vessels have various wall designs, including various aluminum alloys, honeycomb, and carbon-fiber composite materials. For some of the vessels, shielding is being considered. This program involved the test and analysis of six pressure vessel designs, one of which included a Whipple bumper shield. In addition to the pressure vessel walls, all the pressure vessels are wrapped in multi-layer insulation (MLI). Two variants were tested without the MLI to better understand the role of the MLI in the impact performance. The tests of performed were to examine the secondary impacts on these structures as they rested on the Lunar surface. If a hypervelocity meteor were to strike the surface nearby, it would throw regolith and rock debris into the structure at a much lower velocity. Also, when the manned module departs for the return to Earth, its rocket engines throw up debris that can impact the remaining lander components and cause damage. Glass spheres were used as a stimulant for the regolith material. Impact tests were performed with a gas gun to find the V50 of various sized spheres striking the pressure vessels. The impacts were then modeled and a fast-running approximate model for the V50 data was developed. This model was for performing risk analysis to assist in the vessel design and in the identification of ideal long-term mission sites. This paper reviews the impact tests and analysis and modeling examining the impact threat to various components in the lander design.

Development of a dynamic in vitro model of a stented blood vessel to evaluate the effects of stent strut material selection and surface coating on smooth muscle cell response

NASA Astrophysics Data System (ADS)

Winn, Bradley Huegh

Cardiovascular disease is the leading cause of mortality in The United States and Europe, accounting for approximately half of all deaths. The most common form of cardiovascular disease is atherosclerosis, which is characterized by the formation of fatty atheromatous plaques that can grow to occlude the vessel lumen, thus causing ischemia distal to the occlusion. This is commonly treated using balloon angioplasty, which is usually done in conjunction with the deployment of a stent. Stent deployment helps hold the vessel open following the local injury caused by balloon inflation and prevents elastic recoil and subsequent negative remodeling. Stenting has been shown to significantly reduce restenosis rates from approximately 20-50% without a stent to about 10-30% with stent deployment. However, restenosis still remains the main cause of long-term stent failure. In basic terms, a balloon angioplasty procedure is a forceful displacement of an atherosclerotic lesion serving to widen the vessel lumen to increase blood flow. This procedure causes stretching of the vessel wall, tears in the atherosclerotic plaques, and general damage to the vessel in turn signaling a complex cascade of thrombosis, inflammation, intimal thickening, and vascular remodeling. Stent deployment also further complicates the immunological response by triggering a foreign body response from the implantation of a biomaterial into the body. When performing an angioplasty procedure, particularly in conjunction with stent deployment, a certain degree of vascular injury is inevitable. However, the initial injury can be further complicated by the body's local reaction to the implanted biomaterial, the severity of which can ultimately dictate the degree of restenosis and subsequently affect procedural success. The proliferative response of VSMCs to the various afore mentioned stimuli results in the formation of often copious amounts of neointimal tissue, generally known as intimal hyperplasia. The formation of this new tissue, primarily consisting of VSMCs of the synthetic phenotype and their subsequent extracellular matrix, is the sole causation of in-stent restenosis since the stent serves to prevent elastic recoil and negative remodeling. This doctoral research program is focused on endovascular stent biomaterials science and engineering. Overall, this doctoral project is founded on the hypothesis that smooth muscle cell hyperplasia, as an important causative factor for vascular restenosis following endovascular stent deployment, is triggered by the various effects of stent strut contact on the vessel wall including contact forces and material biocompatibility. In this program, a dynamic in vitro model of a stented blood vessel aimed at evaluating the effect of stent strut material selection, and surface coating on smooth muscle cell response was developed. The in vitro stented artery model was validated through the proliferation of VSMC in contact with stent struts. Additionally, it was demonstrated that, with respect to known biocompatible materials such as Nitinol and 316L stainless steel, DNA synthesis and alpha-actin expression, as indicators of VSMC phenotype, are independent of stent material composition. Furthermore, hydroxyapatite was shown to be a biocompatible stent surface coating with acceptable post-strain integrity. This coating was shown in a feasibility study to be capable of serving as a favorable drug delivery platform able to reliably deliver locally therapeutic doses of bisphosphonates, such as alendronate, to control VSMC proliferation in an in vitro model of a stented blood vessel. This stent coating/drug combination may be effective for reducing restenosis as a result of VSMC hyperplasia in vivo.

33 CFR 101.125 - Approved Alternative Security Programs.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 106 of this subchapter, as applicable: (a) American Gaming Association Alternative Security Program..., and Towboats and Barges, dated September 24, 2003. (c) Passenger Vessel Association Industry Standards...

50 CFR 85.22 - Grant proposals.

Code of Federal Regulations, 2010 CFR

2010-10-01

...) FINANCIAL ASSISTANCE-WILDLIFE SPORT FISH RESTORATION PROGRAM CLEAN VESSEL ACT GRANT PROGRAM Application for..., education, sensitive waters, public access, and estimated costs; (e) Amount and source of matching funds...

DEVELOPMENT OF ASME SECTION X CODE RULES FOR HIGH PRESSURE COMPOSITE HYDROGEN PRESSURE VESSELS WITH NON-LOAD SHARING LINERS

DOE Office of Scientific and Technical Information (OSTI.GOV)

Rawls, G.; Newhouse, N.; Rana, M.

2010-04-13

The Boiler and Pressure Vessel Project Team on Hydrogen Tanks was formed in 2004 to develop Code rules to address the various needs that had been identified for the design and construction of up to 15000 psi hydrogen storage vessel. One of these needs was the development of Code rules for high pressure composite vessels with non-load sharing liners for stationary applications. In 2009, ASME approved new Appendix 8, for Section X Code which contains the rules for these vessels. These vessels are designated as Class III vessels with design pressure ranging from 20.7 MPa (3,000 ps)i to 103.4 MPamore » (15,000 psi) and maximum allowable outside liner diameter of 2.54 m (100 inches). The maximum design life of these vessels is limited to 20 years. Design, fabrication, and examination requirements have been specified, included Acoustic Emission testing at time of manufacture. The Code rules include the design qualification testing of prototype vessels. Qualification includes proof, expansion, burst, cyclic fatigue, creep, flaw, permeability, torque, penetration, and environmental testing.« less

Major refit of R/V MARION DUFRESNE and giant sediment corer improvements

NASA Astrophysics Data System (ADS)

Leau, Hélène; Réaud, Yvan

2015-04-01

The french Research Vessel MARION DUFRESNE is equipped with a unique sediment coring facility, called CALYPSO, developed initially by Yvon BALUT at the French Polar Institute, Paul-Emile Victor (IPEV) that operates the vessel 217 days per year in all oceans. The CALYPSO sediment corer retrieves routinely 50 m long undisturbed sediment cores in any water depths, and presently holds the worldwide record of the longest core ever retrieved, that is 64.5 m. This vessel is then a fantastic opportunity for the paleoceanographic community to carry out expeditions at sea. Over the last 20 years, many international IMAGES coring expeditions were organized in all the ocean basins around the world on board the R/V MARION DUFRESNE. More than 1500 cores were retrieved, leading to major advances in the paleoceanography and paleoclimatology of the Late Quaternary. The vessel will celebrate her 20th anniversary in 2015 and will undergo a major refit on hull & machineries, public spaces, as well as scientific equipment. The coring capacity is currently being developed to further improve - The length of the retrievable core, with an objective of 75 m long core in routine - The quality of the sediment un-disturbance with a specially designed coring cable with controlled minimum elasticity - The safety of the operations at sea - The quality control of the operations with a suite of sensors and software allowing a detailed monitoring of the coring operation - The time requested for each operation - The environment data collection, in the same time as the coring operations The detailed description of the upgrades will be presented. They consist in a new suite of acoustic sensors that will be integrated on board the vessel during the 4 months ship yard stay from April to July 2015, amongst which a KONSBERG EM122 multibeam echo-sounder and a SBP 120-3 sub-bottom profiler, both mounted on a gondola fitted under the hull of the vessel. This equipment will allow the highest quality images of the seabed and upper sediment, allowing accurate survey of the coring targets. Scientific deck equipment, such as coring winch and associated A frame, hydrological winch and deployment system, will be upgraded, the coring operating equipment being brought up to 45 t SWL. The ship side will be modified to allow the deployment of 75 m long corer. Finally, the laboratories will be renovated and the main PC room will be redistributed in order to offer more space to the scientific party and secure a new IT dedicated room. The vessel will undergo a series of tests at sea before being available to the scientific community again from January 2016. As before her midlife refit, IPEV wishes to carry on training programs such as "University at Sea" and EGU supported "Teachers at sea" program in association with future paleoceanographic activities.

Composite Overwrapped Pressure Vessels (COPV) Stress Rupture Test: Part 2. Part 2

NASA Technical Reports Server (NTRS)

Russell, Richard; Flynn, Howard; Forth, Scott; Greene, Nathanael; Kezirian, Michael; Varanauski, Don; Leifeste, Mark; Yoder, Tommy; Woodworth, Warren

2010-01-01

One of the major concerns for the aging Space Shuttle fleet is the stress rupture life of composite overwrapped pressure vessels (COPVs). Stress rupture life of a COPY has been defined as the minimum time during which the composite maintains structural integrity considering the combined effects of stress levels and time. To assist in the evaluation of the aging COPVs in the Orbiter fleet an analytical reliability model was developed. The actual data used to construct this model was from testing of COPVs constructed of similar, but not exactly same materials and pressure cycles as used on Orbiter vessels. Since no actual Orbiter COPV stress rupture data exists the Space Shuttle Program decided to run a stress rupture test to compare to model predictions. Due to availability of spares, the testing was unfortunately limited to one 40" vessel. The stress rupture test was performed at maximum operating pressure at an elevated temperature to accelerate aging. The test was performed in two phases. The first phase, 130 F, a moderately accelerated test designed to achieve the midpoint of the model predicted point reliability. A more aggressive second phase, performed at 160 F, was designed to determine if the test article will exceed the 95% confidence interval ofthe model. In phase 3, the vessel pressure was increased to above maximum operating pressure while maintaining the phase 2 temperature. After reaching enough effectives hours to reach the 99.99% confidence level of the model phase 4 testing began when the temperature was increased to greater than 170 F. The vessel was maintained at phase 4 conditions until it failed after over 3 million effect hours. This paper will discuss the results of this test, it's implications and possible follow-on testing.

Development of Computer Models for the Assessment of Foreign Body Impact Events on Composite Structures

NASA Technical Reports Server (NTRS)

Bucinell, Ronald B.

1997-01-01

The objective of this project was to model the 5-3/4 inch pressure vessels used on the NASA RTOP program in an attempt to learn more about how impact damage forms and what are the residual effects of the resulting damage. A global-local finite element model was developed for the bottle and the states of stress in the bottles were determined down to the constituent level. The experimental data that was generated on the NASA RTOP program was not in a form that enabled the model developed under this grant to be correlated with the experimental data. As a result of this exercise it is recommended that an experimental program be designed using statistical design of experiment techniques to generate data that can be used to isolate the phenomenon that control the formation of impact damage. This data should include residual property determinations so that models for post impact structural integrity can be developed. It is also recommended that the global-local methodology be integrated directly into the finite element code. This will require considerable code development.

Graphite filament wound pressure vessels

NASA Technical Reports Server (NTRS)

Feldman, A.; Damico, J. J.

1972-01-01

Filament wound NOL rings, 4-inch and 8-inch diameter closed-end vessels involving three epoxy resin systems and three graphite fibers were tested to develop property data and fabrication technology for filament wound graphite/epoxy pressure vessels. Vessels were subjected to single-cycle burst tests at room temperature. Manufacturing parameters were established for tooling, winding, and curing that resulted in the development of a pressure/vessel performance factor (pressure x volume/weight) or more than 900,000 in. for an oblate spheroid specimen.

50 CFR 679.93 - Amendment 80 Program recordkeeping, permits, monitoring, and catch accounting.

Code of Federal Regulations, 2014 CFR

2014-10-01

... CONSERVATION AND MANAGEMENT, NATIONAL OCEANIC AND ATMOSPHERIC ADMINISTRATION, DEPARTMENT OF COMMERCE (CONTINUED... space to accommodate a minimum of 10 observer sampling baskets. This space must be within or adjacent to... observers assigned to the vessel. (8) Belt and flow operations. The vessel operator stops the flow of fish...

40 CFR Table 1 to Subpart Hhhhh of... - Emission Limits and Work Practice Standards for Process Vessels

Code of Federal Regulations, 2010 CFR

2010-07-01

... PROTECTION AGENCY (CONTINUED) AIR PROGRAMS (CONTINUED) NATIONAL EMISSION STANDARDS FOR HAZARDOUS AIR POLLUTANTS FOR SOURCE CATEGORIES (CONTINUED) National Emission Standards for Hazardous Air Pollutants... to a condenser that reduces the outlet gas temperature to: <10 °C if the process vessel contains HAP...

77 FR 67792 - Proposed Information Collection; Comment Request; Northeast Region Permit Family of Forms

Federal Register 2010, 2011, 2012, 2013, 2014

2012-11-14

... Collection; Comment Request; Northeast Region Permit Family of Forms AGENCY: National Oceanic and Atmospheric... offered in the Northeast region. Exemption programs may allow a vessel to fish in an area that is limited.... Vessels are also required to request gillnet and lobster tags through the Northeast region permit office...

50 CFR 660.314 - Groundfish observer program.

Code of Federal Regulations, 2010 CFR

2010-10-01

... provided to the crew. (2) Safe conditions. Maintain safe conditions on the vessel for the protection of... to safe operation of the vessel, and provisions at §§ 600.725 and 600.746 of this chapter. (3... computer in working condition that contains a full Pentium 120 Mhz or greater capacity processing chip, at...

50 CFR 665.816 - American Samoa longline limited entry program.

Code of Federal Regulations, 2010 CFR

2010-10-01

..., retailer or wholesaler, an American Samoa tax record, an individual wage record, ownership title, vessel registration, or other official documents showing: (i) Ownership of a vessel that was used to fish in the EEZ... issue a request to PIRO to obtain such records from the appropriate agencies, if available. The...

77 FR 2741 - Draft Guidance Regarding Inspection and Certification of Vessels Under the Maritime Security Program

Federal Register 2010, 2011, 2012, 2013, 2014

2012-01-19

... traditional inspection methods to newly reflagged vessels, while at the same time apply a less stringent level... any one of the following methods: (1) Federal eRulemaking Portal: http://www.regulations.gov . (2) Fax... methods. See the ``Public Participation and Request for Comments'' portion of the SUPPLEMENTARY...

A Research Program of Spherical Tokamak in China

NASA Astrophysics Data System (ADS)

He, Ye-xi

2002-08-01

The mission of this program is to explore the spherical torus plasma with a SUNIST spherical tokamak. Main experiments in the start phase will be involved with breakdown and plasma current set-up with a mode of saving volt-second and without ohmic heating system, equilibrium and instability, current driving, heating and profile modification. The SUNIST is a university-scale conceptual spherical tokamak, with R = 0.3 m, A 1.3, Ip ~ 50 kA, BT < 0.15 T, and PRF = 100 kW. The only peculiarity of SUNIST is that there is a toroidal insulating break along the outer wall of vacuum vessel. The expected that advantages of this arrangement are helpful not only for saving flux swing, but also for having a deep understanding of what will influence the discharge startup and globe performances of plasma under different conditions of strong vessel eddy and ECR power assistance. Of course, the vessel structure of cross seal will be at a great risk of controlling vacuum quality, although we have achieved positive results on simulation test and vacuum vessel test.

Energy use in the marine transportation industry: Task III. Efficiency improvements; Task IV. Industry future. Final report, Volume IV. [Projections for year 2000

DOE Office of Scientific and Technical Information (OSTI.GOV)

None

1977-12-01

Tasks III and IV measure the characteristics of potential research and development programs that could be applied to the maritime industry. It was necessary to identify potential operating scenarios for the maritime industry in the year 2000 and determine the energy consumption that would result given those scenarios. After the introductory chapter the operational, regulatory, and vessel-size scenarios for the year 2000 are developed in Chapter II. In Chapter III, future cargo flows and expected levels of energy use for the baseline 2000 projection are determined. In Chapter IV, the research and development programs are introduced into the future USmore » flag fleet and the energy-savings potential associated with each is determined. The first four appendices (A through D) describe each of the generic technologies. The fifth appendix (E) contains the baseline operating and cost parameters against which 15 program areas were evaluated. (MCW)« less

Internet (WWW) based system of ultrasonic image processing tools for remote image analysis.

PubMed

Zeng, Hong; Fei, Ding-Yu; Fu, Cai-Ting; Kraft, Kenneth A

2003-07-01

Ultrasonic Doppler color imaging can provide anatomic information and simultaneously render flow information within blood vessels for diagnostic purpose. Many researchers are currently developing ultrasound image processing algorithms in order to provide physicians with accurate clinical parameters from the images. Because researchers use a variety of computer languages and work on different computer platforms to implement their algorithms, it is difficult for other researchers and physicians to access those programs. A system has been developed using World Wide Web (WWW) technologies and HTTP communication protocols to publish our ultrasonic Angle Independent Doppler Color Image (AIDCI) processing algorithm and several general measurement tools on the Internet, where authorized researchers and physicians can easily access the program using web browsers to carry out remote analysis of their local ultrasonic images or images provided from the database. In order to overcome potential incompatibility between programs and users' computer platforms, ActiveX technology was used in this project. The technique developed may also be used for other research fields.

33 CFR 155.1052 - Response plan development and evaluation criteria for vessels carrying group V petroleum oil as a...

Code of Federal Regulations, 2011 CFR

2011-07-01

... evaluation criteria for vessels carrying group V petroleum oil as a primary cargo. 155.1052 Section 155.1052....1052 Response plan development and evaluation criteria for vessels carrying group V petroleum oil as a primary cargo. (a) Owners and operators of vessels that carry group V petroleum oil as a primary cargo...

Improved Methodology for Developing Cost Uncertainty Models for Naval Vessels

DTIC Science & Technology

2009-04-22

Deegan , 2007). Risk cannot be assessed with a point estimate, as it represents a single value that serves as a best guess for the parameter to be...or stakeholders ( Deegan & Fields, 2007). This paper analyzes the current NAVSEA 05C Cruiser (CG(X)) probabilistic cost model including data...provided by Mr. Chris Deegan and his CG(X) analysts. The CG(X) model encompasses all factors considered for cost of the entire program, including

Sustainment of Expeditionary Forces in the Pacific Theater during the Second World War: The Development of the Advanced Base and Mobile Base Programs and Their Relevance Today

DTIC Science & Technology

2013-04-19

37 7 Preface As a logistics officer, I am naturally inclined to see military...providing a stabilizing presence, conducting humanitarian assistance and disaster response, and deterring and defeating aggression.5 These missions will...Context In retrospect, it is tempting to consider the underway replenishment of seagoing vessels and the advanced base concept as a natural

The Effects of Protein Regulators on the Vascular Remodeling of Japanese Quail Chorioallantoic Membrane

NASA Technical Reports Server (NTRS)

Deshpande, Arati

2004-01-01

Contributing to NASA s mission, the Microgravity Fluid Physics research program conducts experiments to promote space exploration and improvement of processes and products on Earth. One of the projects through this program deals with the affect of regulators on vascular remodeling and angiogenesis. This project is being led by Dr. Patricia Parsons-Wingerter. To perform the experiments, protein regulators are tested on the chorioallantoic membrane (CAM) of the Japanese quail embryos. The different types of regulators used can be broken down into two major groups of stimulators, and inhibitors. Stimulators increase the rate of blood vessel growth and inhibitors decrease of blood vessel growth. The specified regulator proteins include thrombospondin 1 (TSP-1) and a novel vessel tortuosity factor (TF), these are just the ones used in this specific experiment; other various protein regulators can also be used. The novel vessel tortuosity factor (TF) is a special kind of stimulator because it stimulates vessel tortuosity and curvature, rather than actual blood vessel growth. These regulators are being tested on Japanese quail embryos. The Japanese quail embryos naturally form a chorioallantoic membrane (CAM) from which blood flow, vascular remodeling, and angiogenesis can be observed. Chorioallantoic membranes are also easier to use because they are two dimensional when mounted onto a slide for examination. The analysis of the affect of the regulators on the CAM can be studied through PIVPROC; the program is used to analyze the altered blood flow in response to application of TF. Regulators are being thoroughly studied because cardiovascular alterations are the second highest, NASA-defined, risk categories in human space exploration. This research done on the quail is extending to even more projects that will be done on lab animals such as mice and also in human clinical studies like the diabetic retina. Not only will this research be beneficial to further space exploration, but it will also help life here on Earth. The higher understanding of the formation of blood vessels can also help further research in health problems such as diabetes and heart disease.

Improvement of retinal blood vessel detection by spur removal and Gaussian matched filtering compensation

NASA Astrophysics Data System (ADS)

Xiao, Di; Vignarajan, Janardhan; An, Dong; Tay-Kearney, Mei-Ling; Kanagasingam, Yogi

2016-03-01

Retinal photography is a non-invasive and well-accepted clinical diagnosis of ocular diseases. Qualitative and quantitative assessment of retinal images is crucial in ocular diseases related clinical application. In this paper, we proposed approaches for improving the quality of blood vessel detection based on our initial blood vessel detection methods. A blood vessel spur pruning method has been developed for removing the blood vessel spurs both on vessel medial lines and binary vessel masks, which are caused by artifacts and side-effect of Gaussian matched vessel enhancement. A Gaussian matched filtering compensation method has been developed for removing incorrect vessel branches in the areas of low illumination. The proposed approaches were applied and tested on the color fundus images from one publicly available database and our diabetic retinopathy screening dataset. A preliminary result has demonstrated the robustness and good performance of the proposed approaches and their potential application for improving retinal blood vessel detection.

From Deck Hand to Program Manager - 30 years with Research Vessels

NASA Astrophysics Data System (ADS)

Prince, J. M.

2012-12-01

Starting in 1980 as a Mate and Deck Hand and working my way up to Captain, Marine Superintendent, UNOLS Executive Secretary and now as an ONR Research Facilities Program Manager focused on the acquisition of two new Ocean Class Research Vessels, I have witnessed first hand the evolution of the U.S. Academic Research Fleet. The author will focus on a few key events in the evolution of the modern research fleet. As a deck hand, mate and Captain, I was involved in an early multi-disciplinary effort often using two ships working together to conduct sampling and analysis in Physical, Chemical and Biological oceanography. The VERTEX cruises led by John Martin and others used the R/V CAYUSE and R/V WECOMA extensively through out the NE Pacific Ocean conducting research that led to Dr. Martin's Iron Hypothesis. This work and that of others involving trace metal clean sampling and clean laboratories on board our ships pushed many new and demanding requirements for future vessels. As a ship scheduler and as chair of the Research Vessel Operators Committee (RVOC) I saw the increasing use of Remotely Operated Vehicles to complement the work being done with the ALVIN and other occupied submersibles. This led to scheduling challenges and changes to our safety standards, but also to many new opportunities for discoveries on the many mid-ocean ridges and hydro-thermal vent fields. More recently, Autonomous Underwater Vehicles (AUV) and Unmanned Aerial Vehicles (UAV) and aircraft have been used simultaneously with research vessels such as during a multi-PI, multi-ship program in the Monterey Bay. Communications at sea have changed dramatically in the past thirty years. No longer are we limited to reading the data from a spreadsheet over a Single Side Band radio so that the PI ashore can track the progress of a cruise and provide guidance for the next day's sampling. Full bandwidth communications are becoming the norm with the capability of streaming video from an ROV to shore or to exchange data for real-time modeling updates. These new technologies and the multi-disciplinary nature of ocean science research projects have led to many improvements to our Science Mission Requirements for new research vessels. In the next three to four years, three new research vessels will come on line followed by the possibility of three additional Regional Class research vessels. All of these new vessels will come with improved capabilities to support research projects of the future.

Improved fireman's compressed air breathing system pressure vessel development program

NASA Technical Reports Server (NTRS)

King, H. A.; Morris, E. E.

1973-01-01

Prototype high pressure glass filament-wound, aluminum-lined pressurant vessels suitable for use in a fireman's compressed air breathing system were designed, fabricated, and acceptance tested in order to demonstrate the feasibility of producing such high performance, lightweight units. The 4000 psi tanks have a 60 standard cubic foot (SCF) air capacity, and have a 6.5 inch diamter, 19 inch length, 415 inch volume, weigh 13 pounds when empty, and contain 33 percent more air than the current 45 SCF (2250 psi) steel units. The current steel 60 SCF (3000 psi) tanks weigh approximately twice as much as the prototype when empty, and are 2 inches, or 10 percent shorter. The prototype units also have non-rusting aluminum interiors, which removes the hazard of corrosion, the need for internal coatings, and the possibility of rust particles clogging the breathing system.

Vasculitis: determinants of disease patterns.

PubMed

Hoffman, Gary S; Calabrese, Leonard H

2014-08-01

The vasculitides are a large group of heterogeneous diseases for which it has been assumed that pathogenesis is largely autoimmune. As clinicians, we distinguish one form of vasculitis from another on the basis of observed patterns of organ injury, the size of the vessels affected and histopathological findings. The terms 'small-vessel', 'medium-vessel' and 'large-vessel' vasculitis are useful clinical descriptors, but fail to inform us about why vessels of a certain calibre are favoured by one disease and not another. Classification based on vessel size also fails to consider that vessels of a specific calibre are not equally prone to injury. Distinct vulnerabilities undoubtedly relate to the fact that same-size vessels in different tissues may not be identical conduits. In fact, vessels become specialized, from the earliest stages of embryonic development, to suit the needs of different anatomical locations. Vessels of the same calibre in different locations and organs are as different as the organ parenchymal cells through which they travel. The dialogue between developing vessels and the tissues they perfuse is designed to meet special local needs. Added to the story of vascular diversity and vulnerability are changes that occur during growth, development and ageing. An improved understanding of the unique territorial vulnerabilities of vessels could form the basis of new hypotheses for the aetiopathogenesis of the vasculitides. This Review considers how certain antigens, including infectious agents, might become disease-relevant and how vascular diversity could influence disease phenotypes and the spectrum of vascular inflammatory diseases.

Development of a Pebble-Bed Liquid-Nitrogen Evaporator and Superheater for the Scaled Large Blast/Thermal Simulator Facility

DTIC Science & Technology

1991-04-01

Boiler and Pressure Vessel Code . Other design requirements are developed from standard safe... Boiler and Pressure Vessel Code . The following three condi- tions constitute the primary design parameters for pressure vessels: (a) Design Working...rules and practices of the American Society of Mechanical Engineers (ASME) Boiler and Pressure Vessel Code . Section VIII, Division 1 of the ASME

An operational computer program to control Self Defense Surface Missile System operations

DOE Office of Scientific and Technical Information (OSTI.GOV)

Roe, C.L.

1991-12-01

An account is given of the system architecture and operational protocols of the NATO Seasparrow Surface Missile System (NSSMS) Operational Computer Program (OCP) which has been developed, and is being deployed multinationally, to respond against antiship missiles. Flowcharts are presented for the target detection and tracking, control, and engagement phases of the Self Defense Surface Missile System that is controlled by the OCP. USN and other NATO vessels will carry the NSSMS well into the next century; the OCP presently described will be deployed in the course of 1992 to enhance the self-defense capabilities of the NSSMS-equipped fleet. 8 refs.

Materials technology for an advanced space power nuclear reactor concept: Program summary

NASA Technical Reports Server (NTRS)

Gluyas, R. E.; Watson, G. K.

1975-01-01

The results of a materials technology program for a long-life (50,000 hr), high-temperature (950 C coolant outlet), lithium-cooled, nuclear space power reactor concept are reviewed and discussed. Fabrication methods and compatibility and property data were developed for candidate materials for fuel pins and, to a lesser extent, for potential control systems, reflectors, reactor vessel and piping, and other reactor structural materials. The effects of selected materials variables on fuel pin irradiation performance were determined. The most promising materials for fuel pins were found to be 85 percent dense uranium mononitride (UN) fuel clad with tungsten-lined T-111 (Ta-8W-2Hf).

Rapid Deployment of a RESTful Service for Oceanographic Research Cruises

NASA Astrophysics Data System (ADS)

Fu, Linyun; Arko, Robert; Leadbetter, Adam

2014-05-01

The Ocean Data Interoperability Platform (ODIP) seeks to increase data sharing across scientific domains and international boundaries, by providing a forum to harmonize diverse regional data systems. ODIP participants from the US include the Rolling Deck to Repository (R2R) program, whose mission is to capture, catalog, and describe the underway/environmental sensor data from US oceanographic research vessels and submit the data to public long-term archives. R2R publishes information online as Linked Open Data, making it widely available using Semantic Web standards. Each vessel, sensor, cruise, dataset, person, organization, funding award, log, report, etc, has a Uniform Resource Identifier (URI). Complex queries that federate results from other data providers are supported, using the SPARQL query language. To facilitate interoperability, R2R uses controlled vocabularies developed collaboratively by the science community (eg. SeaDataNet device categories) and published online by the NERC Vocabulary Server (NVS). In response to user feedback, we are developing a standard programming interface (API) and Web portal for R2R's Linked Open Data. The API provides a set of simple REST-type URLs that are translated on-the-fly into SPARQL queries, and supports common output formats (eg. JSON). We will demonstrate an implementation based on the Epimorphics Linked Data API (ELDA) open-source Java package. Our experience shows that constructing a simple portal with limited schema elements in this way can significantly reduce development time and maintenance complexity.

NTS—A nanosatellite space trial

NASA Astrophysics Data System (ADS)

Coleshill, Elliott; Cain, Jeff; Newland, Franz; D'Souza, Ian

2010-05-01

The COM DEV Mission Development Group has recently launched a nanosatellite mission called NTS (Nanosatellite Tracking of Ships). NTS is a space trial, intended to provide proof-of-concept validation for a COM DEV AIS (Automatic Identification System) radio that has been specifically designed to receive ship AIS transmissions from low Earth orbit. The AIS system uses the very high frequency (VHF) band and provides detailed information about each equipped vessel. Not only does this system provide information such as the location of a vessel, but it also provides heading, engine status and other crucial information about the ship. Designed for terrestrial use, the AIS system traditionally has a range of only 100 km and uses a local self-organized time-division multiple access (SO-TDMA) scheme to ensure transmissions from all ships in any self-organized cell do not overlap. Receiving these signals from a space platform presents an opportunity to provide wide area monitoring of shipping activity. Detection of AIS signals from space will provide a new capability to track and monitor large maritime vessels even when there are large distances from traditional shore based detection systems. The NTS program was designed to be a low cost demonstration satellite and provide rapid risk mitigation to assist in the development of a future constellation of spacecraft that could provide operational AIS from space (AIS-S) reception and dissemination. The scope of the NTS program was kept to a minimum with focus on the design, development and demonstration of a new payload. The nanosatellite bus was developed using a combination of pre-existing designs by the University of Toronto Institute of Aerospace Studies/Space Flight Laboratory (UTIAS/SFL). The resulting bus design was a combination of their CanX-2 and Generic Nanosatellite Bus. The NTS spacecraft is able to provide the capability to detect AIS signals from low earth orbit with multiple, short AIS signal collection cycles over its planned mission lifetime. The paper presents an overview of the NTS spacecraft, mission concept and preliminary results obtained from the flight.

50 CFR 86.20 - What activities are eligible for funding?

Code of Federal Regulations, 2010 CFR

2010-10-01

... program, or the Clean Vessel Act pumpout grant program also administered by us, to pay for a pumpout...) Produce information and education materials such as charts, cruising guides, and brochures. ...

77 FR 34215 - Special Local Regulations for Marine Events, Swim Event; Lake Gaston, Littleton, NC

Federal Register 2010, 2011, 2012, 2013, 2014

2012-06-11

... material to the docket, call Renee V. Wright, Program Manager, Docket Operations, telephone (202) 366-9826... along the western side of Eaton Ferry Bridge to the Waterview Restaurant. A fleet of spectator vessels... operation of any support vessel participating in the event, at any time it is deemed necessary for the...

76 FR 15826 - Fisheries of the Exclusive Economic Zone Off Alaska; Gulf of Alaska License Limitation Program

Federal Register 2010, 2011, 2012, 2013, 2014

2011-03-22

... or non-trawl gear designations); and (4) designate the type of vessel operation permitted (i.e., LLP... catcher/processor). The endorsements for specific regulatory areas, gear designations, and vessel operational types are non-severable from the LLP license (i.e., once an LLP license is issued, the components...

40 CFR Table 5 to Subpart G of... - Group 1 Storage Vessels at Existing Sources

Code of Federal Regulations, 2011 CFR

2011-07-01

... 40 Protection of Environment 9 2011-07-01 2011-07-01 false Group 1 Storage Vessels at Existing Sources 5 Table 5 to Subpart G of Part 63 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR PROGRAMS (CONTINUED) NATIONAL EMISSION STANDARDS FOR HAZARDOUS AIR POLLUTANTS FOR SOURCE CATEGORIES National Emission Standards for...

40 CFR Table 5 to Subpart G of... - Group 1 Storage Vessels at Existing Sources

Code of Federal Regulations, 2010 CFR

2010-07-01

... 40 Protection of Environment 9 2010-07-01 2010-07-01 false Group 1 Storage Vessels at Existing Sources 5 Table 5 to Subpart G of Part 63 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR PROGRAMS (CONTINUED) NATIONAL EMISSION STANDARDS FOR HAZARDOUS AIR POLLUTANTS FOR SOURCE CATEGORIES National Emission Standards for...

75 FR 45098 - Magnuson-Stevens Act Provisions; General Provisions for Domestic Fisheries; Application for...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-08-02

... outside of the limited access scallop days-at-sea (DAS) program and the sea scallop access area...-day trip for 28 total DAS. The vessels would deploy both dredges simultaneously in 12 30-minute tows... commercial fishing vessels to fish outside of the limited access Atlantic sea scallop days at sea (DAS...

40 CFR Table 5 to Subpart G of... - Group 1 Storage Vessels at Existing Sources

Code of Federal Regulations, 2014 CFR

2014-07-01

... 40 Protection of Environment 10 2014-07-01 2014-07-01 false Group 1 Storage Vessels at Existing Sources 5 Table 5 to Subpart G of Part 63 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR PROGRAMS (CONTINUED) NATIONAL EMISSION STANDARDS FOR HAZARDOUS AIR POLLUTANTS FOR SOURCE CATEGORIES National Emission Standards for...

40 CFR Table 5 to Subpart G of... - Group 1 Storage Vessels at Existing Sources

Code of Federal Regulations, 2013 CFR

2013-07-01

... 40 Protection of Environment 10 2013-07-01 2013-07-01 false Group 1 Storage Vessels at Existing Sources 5 Table 5 to Subpart G of Part 63 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR PROGRAMS (CONTINUED) NATIONAL EMISSION STANDARDS FOR HAZARDOUS AIR POLLUTANTS FOR SOURCE CATEGORIES National Emission Standards for...

40 CFR Table 5 to Subpart G of... - Group 1 Storage Vessels at Existing Sources

Code of Federal Regulations, 2012 CFR

2012-07-01

... 40 Protection of Environment 10 2012-07-01 2012-07-01 false Group 1 Storage Vessels at Existing Sources 5 Table 5 to Subpart G of Part 63 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR PROGRAMS (CONTINUED) NATIONAL EMISSION STANDARDS FOR HAZARDOUS AIR POLLUTANTS FOR SOURCE CATEGORIES National Emission Standards for...

Experimental Investigation of the Shuttle Transportation System Composite Overwrapped Pressure Vessels for Stress Rupture Life

NASA Technical Reports Server (NTRS)

Greene, Nathanael; Saulsberry, Regor; Yoder, Tommy; Forsyth, Brad; Carillo, Marlene; Thesken, John

2006-01-01

A viewgraph presentation describing stress rupture testing on Composite Overwrapped Pressure Vessels (COPV) is shown. The topics include: 1) Purpose for Testing; 2) NASA WSTF COPV Test Program; 3) NASA WSTF Test Facilities; 4) COPV Impact Study; 5) Fluids Compatibility Testing; 6) Stress Rupture Testing; and 7) COPV Lifting.

50 CFR 622.20 - Individual fishing quota (IFQ) program for Gulf groupers and tilefishes.

Code of Federal Regulations, 2011 CFR

2011-10-01

.... Factors considered in the review include the catch subject to the IFQ cost recovery, projected ex-vessel... landings. Appeals based on hardship factors will not be considered. Appeals must be submitted to the RA..., time, and location of transaction; weight and actual ex-vessel value of groupers and tilefishes landed...

50 CFR 622.20 - Individual fishing quota (IFQ) program for Gulf groupers and tilefishes.

Code of Federal Regulations, 2010 CFR

2010-10-01

.... Factors considered in the review include the catch subject to the IFQ cost recovery, projected ex-vessel... landings. Appeals based on hardship factors will not be considered. Appeals must be submitted to the RA..., time, and location of transaction; weight and actual ex-vessel value of groupers and tilefishes landed...

77 FR 10724 - Western Pacific Pelagic Fisheries; American Samoa Longline Limited Entry Program

Federal Register 2010, 2011, 2012, 2013, 2014

2012-02-23

... size class falls below the maximum allowed. Six permits are available, as follows: Four in Class A (vessels less than or equal to 40 ft in overall length); and Two in Class D (over 70 ft in overall length... the highest priority to the applicant (for any vessel size class) with the earliest documented...

A simple design for microwave assisted digestion vessel with low reagent consumption suitable for food and environmental samples

NASA Astrophysics Data System (ADS)

Gholami, Mehrdad; Behkami, Shima; Zain, Sharifuddin Md.; Bakirdere, Sezgin

2016-11-01

The objective of this work is to prepare a cost-effective, low reagent consumption and high performance polytetrafluoroethylene (PTFE) vessel that is capable to work in domestic microwave for digesting food and environmental samples. The designed vessel has a relatively thicker wall compared to that of commercial vessels. In this design, eight vessels are placed in an acrylonitrile butadiene styrene (ABS) holder to keep them safe and stable. This vessel needs only 2.0 mL of HNO3 and 1.0 mL H2O2 to digest 100 mg of biological sample. The performance of this design is then evaluated with an ICP-MS instrument in the analysis of the several NIST standard reference material of milk 1849a, rice flour 1568b, spinach leave 1570a and Peach Leaves 1547 in a domestic microwave oven with inverter technology. Outstanding agreement to (SRM) values are observed by using the suggested power to time microwave program, which simulates the reflux action occurring in this closed vessel. Taking into account the high cost of commercial microwave vessels and the volume of chemicals needed for various experiments (8-10 mL), this simple vessel is cost effective and suitable for digesting food and environmental samples.

Neonatal systemic inflammation in rats alters retinal vessel development and simulates pathologic features of retinopathy of prematurity.

PubMed

Hong, Hye Kyoung; Lee, Hyun Ju; Ko, Jung Hwa; Park, Ji Hyun; Park, Ji Yeon; Choi, Chang Won; Yoon, Chang-Hwan; Ahn, Seong Joon; Park, Kyu Hyung; Woo, Se Joon; Oh, Joo Youn

2014-05-15

Alteration of retinal angiogenesis during development leads to retinopathy of prematurity (ROP) in preterm infants, which is a leading cause of visual impairment in children. A number of clinical studies have reported higher rates of ROP in infants who had perinatal infections or inflammation, suggesting that exposure of the developing retina to inflammation may disturb retinal vessel development. Thus, we investigated the effects of systemic inflammation on retinal vessel development and retinal inflammation in neonatal rats. To induce systemic inflammation, we intraperitoneally injected 100 μl lipopolysaccharide (LPS, 0.25 mg/ml) or the same volume of normal saline in rat pups on postnatal days 1, 3, and 5. The retinas were extracted on postnatal days 7 and 14, and subjected to assays for retinal vessels, inflammatory cells and molecules, and apoptosis. We found that intraperitoneal injection of LPS impaired retinal vessel development by decreasing vessel extension, reducing capillary density, and inducing localized overgrowth of abnormal retinal vessels and dilated peripheral vascular ridge, all of which are characteristic findings of ROP. Also, a large number of CD11c+ inflammatory cells and astrocytes were localized in the lesion of abnormal vessels. Further analysis revealed that the number of major histocompatibility complex (MHC) class IIloCD68loCD11bloCD11chi cells in the retina was higher in LPS-treated rats compared to controls. Similarly, the levels of TNF-α, IL-1β, and IL-12a were increased in LPS-treated retina. Also, apoptosis was increased in the inner retinal layer where retinal vessels are located. Our data demonstrate that systemic LPS-induced inflammation elicits retinal inflammation and impairs retinal angiogenesis in neonatal rats, implicating perinatal inflammation in the pathogenesis of ROP.

Composite Overwrapped Pressure Vessels (COPV) Stress Rupture Test

NASA Technical Reports Server (NTRS)

Russell, Richard; Flynn, Howard; Forth, Scott; Greene, Nathanael; Kezian, Michael; Varanauski, Don; Yoder, Tommy; Woodworth, Warren

2009-01-01

One of the major concerns for the aging Space Shuttle fleet is the stress rupture life of composite overwrapped pressure vessels (COPVs). Stress rupture life of a COPV has been defined as the minimum time during which the composite maintains structural integrity considering the combined effects of stress levels and time. To assist in the evaluation of the aging COPVs in the Orbiter fleet an analytical reliability model was developed. The actual data used to construct this model was from testing of COPVs constructed of similar, but not exactly same materials and pressure cycles as used on Orbiter vessels. Since no actual Orbiter COPV stress rupture data exists the Space Shuttle Program decided to run a stress rupture test to compare to model predictions. Due to availability of spares, the testing was unfortunately limited to one 40" vessel. The stress rupture test was performed at maximum operating pressure at an elevated temperature to accelerate aging. The test was performed in two phases. The first phase, 130 F, a moderately accelerated test designed to achieve the midpoint of the model predicted point reliability. The more aggressive second phase, performed at 160 F was designed to determine if the test article will exceed the 95% confidence interval of the model. This paper will discuss the results of this test, it's implications and possible follow-on testing.

78 FR 30956 - Cruise Vessel Security and Safety Training Provider Certification

Federal Register 2010, 2011, 2012, 2013, 2014

2013-05-23

..., practical demonstration, or simulation program. A detailed instructor manual must be submitted. Submissions... simulation programs to be used. If a simulator or simulation program is to be used, include technical... lessons and, if appropriate, for practical demonstrations or simulation exercises and assessments...

High-performance fiber/epoxy composite pressure vessels

NASA Technical Reports Server (NTRS)

Chiao, T. T.; Hamstad, M. A.; Jessop, E. S.; Toland, R. H.

1978-01-01

Activities described include: (1) determining the applicability of an ultrahigh-strength graphite fiber to composite pressure vessels; (2) defining the fatigue performance of thin-titanium-lined, high-strength graphite/epoxy pressure vessel; (3) selecting epoxy resin systems suitable for filament winding; (4) studying the fatigue life potential of Kevlar 49/epoxy pressure vessels; and (5) developing polymer liners for composite pressure vessels. Kevlar 49/epoxy and graphite fiber/epoxy pressure vessels, 10.2 cm in diameter, some with aluminum liners and some with alternation layers of rubber and polymer were fabricated. To determine liner performance, vessels were subjected to gas permeation tests, fatigue cycling, and burst tests, measuring composite performance, fatigue life, and leak rates. Both the metal and the rubber/polymer liner performed well. Proportionately larger pressure vessels (20.3 and 38 cm in diameter) were made and subjected to the same tests. In these larger vessels, line leakage problems with both liners developed the causes of the leaks were identified and some solutions to such liner problems are recommended.

Scar-free cutaneous wound healing in the leopard gecko, Eublepharis macularius.

PubMed

Peacock, Hanna M; Gilbert, Emily A B; Vickaryous, Matthew K

2015-11-01

Cutaneous wounds heal with two possible outcomes: scarification or near-perfect integumentary restoration. Whereas scar formation has been intensively investigated, less is known about the tissue-level events characterising wounds that spontaneously heal scar-free, particularly in non-foetal amniotes. Here, a spatiotemporal investigation of scar-free cutaneous wound healing following full-thickness excisional biopsies to the tail and body of leopard geckos (Eublepharis macularius) is provided. All injuries healed without scarring. Cutaneous repair involves the development of a cell-rich aggregate within the wound bed, similar to scarring wounds. Unlike scar formation, scar-free healing involves a more rapid closure of the wound epithelium, and a delay in blood vessel development and collagen deposition within the wound bed. It was found that, while granulation tissue of scarring wounds is hypervascular, scar-free wound healing conspicuously does not involve a period of exuberant blood vessel formation. In addition, during scar-free wound healing the newly formed blood vessels are typically perivascular cell-supported. Immunohistochemistry revealed widespread expression of both the pro-angiogenic factor vascular endothelial growth factor A and the anti-angiogenic factor thrombospondin-1 within the healing wound. It was found that scar-free wound healing is an intrinsic property of leopard gecko integument, and involves a modulation of the cutaneous scar repair program. This proportional revascularisation is an important factor in scar-free wound healing. © 2015 Anatomical Society.

Scar-free cutaneous wound healing in the leopard gecko, Eublepharis macularius

PubMed Central

Peacock, Hanna M; Gilbert, Emily A B; Vickaryous, Matthew K

2015-01-01

Cutaneous wounds heal with two possible outcomes: scarification or near-perfect integumentary restoration. Whereas scar formation has been intensively investigated, less is known about the tissue-level events characterising wounds that spontaneously heal scar-free, particularly in non-foetal amniotes. Here, a spatiotemporal investigation of scar-free cutaneous wound healing following full-thickness excisional biopsies to the tail and body of leopard geckos (Eublepharis macularius) is provided. All injuries healed without scarring. Cutaneous repair involves the development of a cell-rich aggregate within the wound bed, similar to scarring wounds. Unlike scar formation, scar-free healing involves a more rapid closure of the wound epithelium, and a delay in blood vessel development and collagen deposition within the wound bed. It was found that, while granulation tissue of scarring wounds is hypervascular, scar-free wound healing conspicuously does not involve a period of exuberant blood vessel formation. In addition, during scar-free wound healing the newly formed blood vessels are typically perivascular cell-supported. Immunohistochemistry revealed widespread expression of both the pro-angiogenic factor vascular endothelial growth factor A and the anti-angiogenic factor thrombospondin-1 within the healing wound. It was found that scar-free wound healing is an intrinsic property of leopard gecko integument, and involves a modulation of the cutaneous scar repair program. This proportional revascularisation is an important factor in scar-free wound healing. PMID:26360824

75 FR 65385 - Advisory Committee for Polar Programs; Notice of Meeting

Federal Register 2010, 2011, 2012, 2013, 2014

2010-10-22

... Antarctic Program review; Strategic Planning; planning for a Polar Research Vessel. Dated: October 19, 2010... research community, to provide advice to the Director of OPP on issues related to long-range planning...

Demonstration of Hazardous Hypervelocity Test Capability

NASA Technical Reports Server (NTRS)

Rodriquez, Karen M.

1991-01-01

NASA Johnson Space Center (JSC) White Sands Test Facility (WSTF) participated in a joint test program with NASA JSC Hypervelocity Impact Research Laboratory (HIRL) to determine if JSC was capable of performing hypervelocity impact tests on hazardous targets. Seven pressurized vessels were evaluated under hypervelocity impact conditions. The vessels were tested with various combinations of liquids and gasses at various pressures. Results from the evaluation showed that vessels containing 100-percent pressurized gas sustained more severe damage and had a higher potential for damaging nearby equipment, than vessels containing 75-percent liquid, 25-percent inert pressurized gas. Two water-filled test vessels, one of which was placed behind an aluminum shield, failed by bulging and splitting open at the impact point; pressure was relieved without the vessel fragmenting or sustaining internal damage. An additional water-filled test vessel, placed a greater distance behind an aluminum shield, sustained damage that resembled a shotgun blast, but did not bulge or split open; again, pressure was relieved without the vessel fragmenting. Two test vessels containing volatile liquids (nitro methane and hydrazine) also failed by bulging and splitting open; neither liquid detonated under hypervelocity test conditions. A test vessel containing nitrogen gas failed by relieving pressure through a circular entry hole; multiple small penetrations opposite the point of entry provided high velocity target debris to surrounding objects. A high-pressure oxygen test vessel fragmented upon impact; the ensuing fire and high velocity fragments caused secondary damage to surrounding objects. The results from the evaluation of the pressurized vessels indicated that JSC is capable of performing hypervelocity impact tests on hazardous targets.

Induction of Pancreatic Differentiation by Signals from Blood Vessels

NASA Astrophysics Data System (ADS)

Lammert, Eckhard; Cleaver, Ondine; Melton, Douglas

2001-10-01

Blood vessels supply developing organs with metabolic sustenance. Here, we demonstrate a role for blood vessels as a source of developmental signals during pancreatic organogenesis. In vitro experiments with embryonic mouse tissues demonstrate that blood vessel endothelium induces insulin expression in isolated endoderm. Removal of the dorsal aorta in Xenopus laevis embryos results in the failure of insulin expression in vivo. Furthermore, using transgenic mice, we show that ectopic vascularization in the posterior foregut leads to ectopic insulin expression and islet hyperplasia. These results indicate that vessels not only provide metabolic sustenance, but also provide inductive signals for organ development.

Development of FB-MultiPier dynamic vessel-collision analysis models, phase 2.

DOT National Transportation Integrated Search

2014-07-01

Massive waterway vessels such as barges regularly transit navigable waterways in the U.S. During passages that fall within : the vicinity of bridge structures, vessels may (under extreme circumstances) deviate from the intended vessel transit path. A...

Continuous earlywood vessels chronologies in floodplain ring-porous species can improve dendrohydrological reconstructions of spring high flows and flood levels

NASA Astrophysics Data System (ADS)

Kames, S.; Tardif, J. C.; Bergeron, Y.

2016-03-01

Plants respond to environmental stimuli through changes in growth and development. Characteristics of wood cells such as the cross-sectional area of vessel elements (hereafter referred to as vessels) may store information about environmental factors present at the time of vessel differentiation. The analysis of vessel characteristics therefore offers a different time resolution than annual ring width because vessels in tree rings differentiate within days to a few weeks. Little research has been conducted on the sensitivity of earlywood vessels in ring-porous species in response to flooding. The general objectives of this study were to determine the plasticity of earlywood vessel to high flows and spring flooding in floodplain black ash (Fraxinus nigra Marsh.) trees and to assess the utility of developing continuous earlywood vessel chronologies in dendrohydrological reconstruction. In contrast, most dendrohydrological studies until now have mainly used vessel anomalies (flood rings) as discrete variables to identify exceptional flood events. The study area is located in the boreal region of northwestern Québec. Vessel and ring-width chronologies were generated from F. nigra trees growing on the floodplain of Lake Duparquet. Spring discharge had among all hydro-climatic variables the strongest impact on vessel formation and this signal was coherent spatially and in the frequency domain. The mean vessel area chronology was significantly and negatively correlated to discharge and both the linearity and the strength of this association were unique. In floodplain F. nigra trees, spring flooding promoted the formation of more abundant but smaller earlywood vessels. Earlywood vessels chronologies were also significantly associated with other hydrological indicators like Lake Duparquet's ice break-up date and both ice-scar frequency and height chronologies. These significant relationships stress the utility of developing continuous vessels chronologies for hydrological reconstructions prior to instrumental data. Continuous earlywood vessel chronologies may also be useful in determining the impact of altered hydrological regime in floodplain habitat regulated by spring floods. Future research should involve quantifying the impact of high flows and flooding on other cell constituents and also determining the plasticity and utility of continuous anatomical series in floodplain diffuse-porous species.

Investigation of laser Doppler techniques using the Monte Carlo method

NASA Astrophysics Data System (ADS)

Ruetten, Walter; Gellekum, Thomas; Jessen, Katrin

1995-01-01

Laser Doppler techniques are increasingly used in research and clinical applications to study perfusion phenomena in the skin, yet the influences of changing scattering parameters and geometry on the measure of perfusion are not well explored. To investigate these influences, a simulation program based on the Monte Carlo method was developed, which is capable of determining the Doppler spectra caused by moving red blood cells. The simulation model allows for the definition of arbitrary networks of blood vessels with individual velocities. The volume is represented by a voxel tree with adaptive spatial resolution which contains references to the optical properties and is used to store the location dependent photon fluence determined during the simulation. Two evaluation methods for Doppler spectra from biological tissue described in the literate were investigated with the simulation program. The results obtained suggest that both methods give a measure of perfusion nearly proportional to the velocity of the red blood cells. However, simulations done with different geometries of the blood vessels seem to indicate a nonlinear behavior concerning the concentration of red blood cells in the measurement volume. Nevertheless these simulation results may help in the interpretation of measurements obtained from devices using the investigated evaluation methods.

76 FR 29707 - Fishing Capacity Reduction Program for the Southeast Alaska Purse Seine Salmon Fishery

Federal Register 2010, 2011, 2012, 2013, 2014

2011-05-23

.... Although the fee could be up to three percent of the ex-vessel price of all post-reduction landings, the... percent of the ex- vessel price of all post-reduction landings, the fee will be less than three percent if... the fishery becomes too exclusive. An ``optimum number'' study by the CFEC would be required before...

Creep failure of a reactor pressure vessel lower head under severe accident conditions

DOE Office of Scientific and Technical Information (OSTI.GOV)

Pilch, M.M.; Ludwigsen, J.S.; Chu, T.Y.

A severe accident in a nuclear power plant could result in the relocation of large quantities of molten core material onto the lower head of he reactor pressure vessel (RPV). In the absence of inherent cooling mechanisms, failure of the RPV ultimately becomes possible under the combined effects of system pressure and the thermal heat-up of the lower head. Sandia National Laboratories has performed seven experiments at 1:5th scale simulating creep failure of a RPV lower head. This paper describes a modeling program that complements the experimental program. Analyses have been performed using the general-purpose finite-element code ABAQUS-5.6. In ordermore » to make ABAQUS solve the specific problem at hand, a material constitutive model that utilizes temperature dependent properties has been developed and attached to ABAQUS-executable through its UMAT utility. Analyses of the LHF-1 experiment predict instability-type failure. Predicted strains are delayed relative to the observed strain histories. Parametric variations on either the yield stress, creep rate, or both (within the range of material property data) can bring predictions into agreement with experiment. The analysis indicates that it is necessary to conduct material property tests on the actual material used in the experimental program. The constitutive model employed in the present analyses is the subject of a separate publication.« less

Launch Conditions Might Affect the Formation of Blood Vessel in the Quail Chorioallantoic Membrane

NASA Technical Reports Server (NTRS)

Henry, M. K.; Unsworth, B. R.; Sychev, B. R.; Guryeva, T. S.; Dadasheva, O. A.; Piert, S. J.; Lagel, K. E.; Dubrovin, L. C.; Jahns, G. C.; Boda, K.;

The estimation of the pollutant emissions on-board vessels by means of numerical methods

NASA Astrophysics Data System (ADS)

Jenaru, A.; Arsenie, P.; Hanzu-Pazara, R.

2016-08-01

Protection of the environment, especially within the most recent years, has become a constant problem considered by the states and the governments of the world, which are more and more concerned about the serious problems caused by the continuous deterioration of the environment. The long term effects of pollution on the environment generated by the lack of penalty regulations, have directed the attention of statesmen upon the necessity of the elaboration of normative acts meant to be effective in the continuous fight with it. Maritime transportation generates approximately 4% of the total of the CO2 emissions produced by human activities. This paper is intended to present two methods of estimation of the gases emissions on-board a vessel, methods that are very useful for the crews which are exploiting them. For the determination and the validation of these methods we are going to use the determinations from the tank ship. This ship has as a main propulsion engine Wärtsilä DU Sulzer RT Flex 50 - 6 cylinders that develops a maximal power of 9720 kW and has a permanent monitoring system of the pollutant emissions. The methods we develop here are using the values of the polluting elements from the exhaust gases that are determined at the exit of the vessel from the ship yard, in the framework of the acceptance tests. These values have been introduced within the framework of a matrix in the MATHCAD program. This matrix represents the starting point of the two mentioned methods: the analytical method and the graphical method. During the study we are going to evaluate the development and validation of an analytical tool to be used to determine the standard of emissions aimed at thermal machines on ships. One of the main objectives of this article represents an objective assessment of the expediency of using non-fuels for internal combustion engines in vessels.

Development of FB-MultiPier dynamic vessel-collision analysis models, phase 2 : [summary].

DOT National Transportation Integrated Search

2014-07-01

When collisions between large vessels and bridge : supports occur, they can result in significant : damage to bridge and vessel. These collisions : are extremely hazardous, often taking lives on : the vessel and the bridge. Direct costs of repair : a...

Study on vessel sewage treatment technologies

NASA Astrophysics Data System (ADS)

Shen, Wei; Xing, Guojing

2017-10-01

In this paper, the author, on the basis of his experience in researches of past years, discusses the status quo and classifications of vessel sewage treatment technology, analyzes problems plaguing current vessel sewage treatment and describes the focuses of development of vessel sewage treatment technology.

Dynamic Patterns of Clonal Evolution in Tumor Vasculature Underlie Alterations in Lymphocyte-Endothelial Recognition to Foster Tumor Immune Escape.

PubMed

Corey, Daniel M; Rinkevich, Yuval; Weissman, Irving L

2016-03-15

Although tumor blood vessels have been a major therapeutic target for cancer chemotherapy, little is known regarding the stepwise development of the tumor microenvironment. Here, we use a multicolor Cre-dependent marker system to trace clonality within the tumor microenvironment to show that tumor blood vessels follow a pattern of dynamic clonal evolution. In an advanced melanoma tumor microenvironment, the vast majority of tumor vasculature clones are derived from a common precursor. Quantitative lineage analysis reveals founder clones diminish in frequency and are replaced by subclones as tumors evolve. These tumor-specific blood vessels are characterized by a developmental switch to a more invasive and immunologically silent phenotype. Gene expression profiling and pathway analysis reveals selection for traits promoting upregulation of alternative angiogenic programs such as unregulated HGF-MET signaling and enhanced autocrine signaling through VEGF and PDGF. Furthermore, we show a developmental switch in the expression of functionally significant primary lymphocyte adhesion molecules on tumor endothelium, such as the loss in expression of the mucosal addressin MAdCAM-1, whose counter receptor a4β7 on lymphocytes controls lymphocyte homing. Changes in adhesive properties on tumor endothelial subclones are accompanied by decreases in expression of lymphocyte chemokines CXCL16, CXCL13, CXCL12, CXCL9, CXCL10, and CCL19. These evolutionary patterns in the expressed genetic program within tumor endothelium will have both a quantitative and functional impact on lymphocyte distribution that may well influence tumor immune function and underlie escape mechanisms from current antiangiogenic pharmacotherapies. ©2015 American Association for Cancer Research.

42 CFR 52e.1 - To what programs do these regulations apply?

Code of Federal Regulations, 2010 CFR

2010-10-01

... HEART, LUNG, AND BLOOD INSTITUTE GRANTS FOR PREVENTION AND CONTROL PROJECTS § 52e.1 To what programs do... the prevention and control of heart, blood vessel, lung, and blood diseases, with special...

42 CFR 52e.1 - To what programs do these regulations apply?

Code of Federal Regulations, 2011 CFR

2011-10-01

... HEART, LUNG, AND BLOOD INSTITUTE GRANTS FOR PREVENTION AND CONTROL PROJECTS § 52e.1 To what programs do... the prevention and control of heart, blood vessel, lung, and blood diseases, with special...

42 CFR 52e.1 - To what programs do these regulations apply?

Code of Federal Regulations, 2013 CFR

2013-10-01

... HEART, LUNG, AND BLOOD INSTITUTE GRANTS FOR PREVENTION AND CONTROL PROJECTS § 52e.1 To what programs do... the prevention and control of heart, blood vessel, lung, and blood diseases, with special...

42 CFR 52e.1 - To what programs do these regulations apply?

Code of Federal Regulations, 2014 CFR

2014-10-01

... HEART, LUNG, AND BLOOD INSTITUTE GRANTS FOR PREVENTION AND CONTROL PROJECTS § 52e.1 To what programs do... the prevention and control of heart, blood vessel, lung, and blood diseases, with special...

42 CFR 52e.1 - To what programs do these regulations apply?

Code of Federal Regulations, 2012 CFR

2012-10-01

... HEART, LUNG, AND BLOOD INSTITUTE GRANTS FOR PREVENTION AND CONTROL PROJECTS § 52e.1 To what programs do... the prevention and control of heart, blood vessel, lung, and blood diseases, with special...

33 CFR 155.5061 - Alternative Training and Exercise Program.

Code of Federal Regulations, 2014 CFR

2014-07-01

... 33 Navigation and Navigable Waters 2 2014-07-01 2014-07-01 false Alternative Training and Exercise... Nontank Vessel Response Plans § 155.5061 Alternative Training and Exercise Program. (a) Owners or... exercise requirements of §§ 155.5055 and 155.5060, may meet an Alternative Training and Exercise Program...

46 CFR 176.650 - Alternative Hull Examination Program options: Divers or underwater ROV.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 46 Shipping 7 2010-10-01 2010-10-01 false Alternative Hull Examination Program options: Divers or...) SMALL PASSENGER VESSELS (UNDER 100 GROSS TONS) INSPECTION AND CERTIFICATION Hull and Tailshaft Examinations § 176.650 Alternative Hull Examination Program options: Divers or underwater ROV. To complete the...

Composite overwrapped metallic tanks

NASA Technical Reports Server (NTRS)

Caudill, C. L.; Kirlin, R. L.

1972-01-01

Work is reported for fabricating and testing the fiberglass overwrapped titanium pressure vessel for cryogenic service. Difficulties encountered in the tank liner fabrication phase involved explosive forming, vacuum annealing, chemical milling and electron beam welding. While each of these processes and the nondestructive test methods employed are normally considered to be individually reliable, the combination of poor material together with fabrication and development reversals prevented the full achievement of the desired end results. Eight tanks plus a prototype and tool proofing article were produced. Six of the vessels failed during the hydrostatic sizing operation. One of the remaining tanks was hydrostatically pressurized to burst and the other was pressurized repeatedly at 75 F from 100 psi to the operating pressure until failure occurred. As a result, it is not possible to draw firm conclusions as to the true value of the design concept due to the problems encountered in the program.

Collaborative investigations of in-service irradiated material from the Japan Power Demonstration Reactor pressure vessel

DOE Office of Scientific and Technical Information (OSTI.GOV)

Corwin, W.R.; Broadhead, B.L.; Suzuki, M.

1997-02-01

There is a need to validate the results of irradiation effects research by the examination of material taken directly from the wall of a pressure vessel that has been irradiated during normal service. Just such an evaluation is currently being conducted on material from the wall of the pressure vessel from the Japan Power Demonstration Reactor (JPDR). The research is being jointly performed at the Tokai Research Establishment of the Japan Atomic Energy Research Institute (JAERI) and by the Nuclear Regulatory Commission (NRC)-funded Heavy-Section Steel Irradiation Program at the Oak Ridge National Laboratory (ORNL).

Label-free optical lymphangiography: development of an automatic segmentation method applied to optical coherence tomography to visualize lymphatic vessels using Hessian filters

PubMed Central

Yousefi, Siavash; Qin, Jia; Zhi, Zhongwei

2013-01-01

Abstract. Lymphatic vessels are a part of the circulatory system that collect plasma and other substances that have leaked from the capillaries into interstitial fluid (lymph) and transport lymph back to the circulatory system. Since lymph is transparent, lymphatic vessels appear as dark hallow vessel-like regions in optical coherence tomography (OCT) cross sectional images. We propose an automatic method to segment lymphatic vessel lumen from OCT structural cross sections using eigenvalues of Hessian filters. Compared to the existing method based on intensity threshold, Hessian filters are more selective on vessel shape and less sensitive to intensity variations and noise. Using this segmentation technique along with optical micro-angiography allows label-free noninvasive simultaneous visualization of blood and lymphatic vessels in vivo. Lymphatic vessels play an important role in cancer, immune system response, inflammatory disease, wound healing and tissue regeneration. Development of imaging techniques and visualization tools for lymphatic vessels is valuable in understanding the mechanisms and studying therapeutic methods in related disease and tissue response. PMID:23922124

The NASA research and technology program on batteries

NASA Technical Reports Server (NTRS)

Bennett, Gary L.

1990-01-01

The NASA research and technology program on batteries is being carried out within the Propulsion, Power and Energy Division (Code RP) of NASA's Office of Aeronautics, Exploration and Technology (OAET). The program includes development of high-performance, long-life, cost-effective primary and secondary (rechargeable) batteries. The NASA OAET battery program is being carried out at Lewis Research Center (LeRC) and the Jet Propulsion Laboratory (JPL). LeRC is focusing primarily on nickel-hydrogen batteries (both individual pressure vessel or IPV and bipolar). LeRC is also involved in a planned flight experiment to test a sodium-sulfur battery design. JPL is focusing primarily on lithium rechargeable batteries, having successfully transferred its lithium primary battery technology to the U.S. Air Force for use on the Centaur upper stage. Both LeRC and JPL are studying advanced battery concepts that offer even higher specific energies. The long-term goal is to achieve 100 Wh/kg.

Automatic segmentation of cortical vessels in pre- and post-tumor resection laser range scan images

NASA Astrophysics Data System (ADS)

Ding, Siyi; Miga, Michael I.; Thompson, Reid C.; Garg, Ishita; Dawant, Benoit M.

2009-02-01

Measurement of intra-operative cortical brain movement is necessary to drive mechanical models developed to predict sub-cortical shift. At our institution, this is done with a tracked laser range scanner. This device acquires both 3D range data and 2D photographic images. 3D cortical brain movement can be estimated if 2D photographic images acquired over time can be registered. Previously, we have developed a method, which permits this registration using vessels visible in the images. But, vessel segmentation required the localization of starting and ending points for each vessel segment. Here, we propose a method, which automates the segmentation process further. This method involves several steps: (1) correction of lighting artifacts, (2) vessel enhancement, and (3) vessels' centerline extraction. Result obtained on 5 images obtained in the operating room suggests that our method is robust and is able to segment vessels reliably.

Air Force Operational Medicine: Using the Enterprise Estimating Supplies Program to Develop Materiel Solutions for the Thoracic/Vascular Surgery Team (FFGKT)

DTIC Science & Technology

2010-11-10

asset, including combat wounds, non-battle injuries , and illnesses. International Classification of Diseases, Ninth Revision (ICD-9) coded patient...patient conditions and the frequency at which they would present. The resulting illness and injury frequencies characterize the expected patient...The scenario is shown in Table 1. Table 1 Thoracic/Vascular Scenario ICD-9 ICD-9 description No. patients 903.9 INJURY ARM VESSEL NOS 2 904.8

Drilling Polar Oceans with the European Research Icebreaker AURORA BOREALIS: the IODP Context

NASA Astrophysics Data System (ADS)

Lembke-Jene, Lester; Wolff-Boenisch, Bonnie; Azzolini, Roberto; Thiede, Joern; Biebow, Nicole; Eldholm, Olav; Egerton, Paul

2010-05-01

Polar oceans are characterized by extreme environmental conditions for humans and materials, and have remained the least accessible regions to scientists of the IODP. DSDP and ODP have for long faced specific technical and logistical problems when attempting to drill in ice-covered polar deep-sea basins. The Arctic Ocean and large areas of the high-latitude Southern Ocean remained largely un-sampled by ODP and remain one of the major scientific and technological challenges for IODP. Drilling in these regions has been discussed and anticipated for decades and the scientific rationales are reflected in the science plans of the international Nansen Arctic Drilling Program (NAD) or the Arctic Program Planning Group (APPG) of ODP/IODP, amongst others. More recently, the rationale to investigate the polar oceans in a holistic approach has been outlined by workshops, leading to strategic assessments of the scientific potential and new drilling proposals. The European Polar Board took the initiative to develop a plan for a novel and dedicated research icebreaker with technical capabilities hitherto unrealised. This research icebreaker will enable autonomous operations in the central Arctic Ocean and the Southern Ocean, even during the severest ice conditions in the deep winter, serving all marine disciplines of polar research including scientific drilling: The European Research Icebreaker and Deep-Sea Drilling Vessel AURORA BOREALIS. AURORA BOREALIS is presently planned as a multi-purpose vessel. The ship can be deployed as a research icebreaker in all polar waters during any season of the year, as it shall meet the specifications of the highest ice-class attainable (IACS Polar Code 1) for icebreakers. During the times when it is not employed for drilling, it will operate as the most technically advanced multi-disciplinary research vessel in the Arctic or polar Southern Ocean. AURORA BOREALIS will be a "European scientific flagship facility" (fully open to non-European partners), a multidisciplinary platform for studies ranging from the sub-seafloor into the atmosphere. AURORA BOREALIS was planned for her role in deep-sea drilling in consultation with engineers and technical experts familiar with the program and the operation of these vessels. All techniques currently deployed on IODP expeditions can be implemented onboard the vessel under polar weather and ice conditions, including the full range of re-entry, casing and cementing, and instrumentation options and the entire suite of downhole logging tools. Due to sufficient laboratory space, a full analytical workflow can be easily established comparable to existing permanent platforms, including clean rooms, diverse scanning and logging or incubation facilities. While the vessel is equipped with a dedicated deep-sea drilling rig, other coring and drilling techniques can be employed if needed (e.g. Rockdrill, MEBO, large diameter Kasten cores). AURORA BOREALIS is fitted to operate a CALYPSO Piston Coring System in polar waters. Future mud-return systems under consideration and testing for IODP to provide controlled borehole conditions in difficult facies are compatible with the layout of AURORA BOREALIS. The berthing capacity of 120 personnel total (scientists, technical support and crew) allows to accommodate a sufficient number of science party members offshore. The present scientific implementation documents plan for about one polar scientific drilling expedition per year in a to-be-determined configuration. As the vessel is a multi-dsiciplinary platform, operations for the entire year are not dependant on drilling operations alone. While principal access to the vessel will be based on a competitive proposal review and evaluation system, the allocation of timeslots specifically for drilling would preferably be given over to IODP handling and planning systems in a cooperative mode using the strengths and capacitites of the future program. Depending on interests and needs of the scientific communities a preferential focus in non-drilling expedition planning could be established e.g. for dedicated geophysical pre-site survey works in areas inaccessible by other vessels to secure critical data needed for later drilling expeditions. Based on ongoing expert consultations, it is safe to assume that the average costs for an Arctic or polar drilling expedition will be considerably lower than with an otherwise necessary multi-ship setup based on modelled expedition scenarios and annual operational cost calculations. Still, AURORA BOREALIS shall provide substantially enhanced scientific, operational, personnel and technical capacities offshore.

BWRVIP-140NP: BWR Vessel and Internals Project Fracture Toughness and Crack Growth Program on Irradiated Austenitic Stainless Steel

DOE Office of Scientific and Technical Information (OSTI.GOV)

Gilman, J

2005-03-15

To prepare for this project, EPRI and BWRVIP conducted a workshop at Ponte Vedra Beach, Florida during February 19-21, 2003 (EPRI report 1007822). Attendees were invited to exchange relevant information on the effects of irradiation on austenitic materials in light water reactors and to produce recommendations for further work. EPRI reviewed the data, recommendations, and conclusions derived from the workshop and developed prioritized test matrices defining new data needs. Proposals were solicited, and selected proposals are the basis for the program described in this report. Results The planned test matrix for fracture toughness testing includes 21 tests on 5 materials.

Renal blood flow and oxygenation drive nephron progenitor differentiation.

PubMed

Rymer, Christopher; Paredes, Jose; Halt, Kimmo; Schaefer, Caitlin; Wiersch, John; Zhang, Guangfeng; Potoka, Douglas; Vainio, Seppo; Gittes, George K; Bates, Carlton M; Sims-Lucas, Sunder

2014-08-01

During kidney development, the vasculature develops via both angiogenesis (branching from major vessels) and vasculogenesis (de novo vessel formation). The formation and perfusion of renal blood vessels are vastly understudied. In the present study, we investigated the regulatory role of renal blood flow and O2 concentration on nephron progenitor differentiation during ontogeny. To elucidate the presence of blood flow, ultrasound-guided intracardiac microinjection was performed, and FITC-tagged tomato lectin was perfused through the embryo. Kidneys were costained for the vasculature, ureteric epithelium, nephron progenitors, and nephron structures. We also analyzed nephron differentiation in normoxia compared with hypoxia. At embryonic day 13.5 (E13.5), the major vascular branches were perfused; however, smaller-caliber peripheral vessels remained unperfused. By E15.5, peripheral vessels started to be perfused as well as glomeruli. While the interior kidney vessels were perfused, the peripheral vessels (nephrogenic zone) remained unperfused. Directly adjacent and internal to the nephrogenic zone, we found differentiated nephron structures surrounded and infiltrated by perfused vessels. Furthermore, we determined that at low O2 concentration, little nephron progenitor differentiation was observed; at higher O2 concentrations, more differentiation of the nephron progenitors was induced. The formation of the developing renal vessels occurs before the onset of blood flow. Furthermore, renal blood flow and oxygenation are critical for nephron progenitor differentiation. Copyright © 2014 the American Physiological Society.

Neutron Fluence And DPA Rate Analysis In Pebble-Bed HTR Reactor Vessel Using MCNP

NASA Astrophysics Data System (ADS)

Hamzah, Amir; Suwoto; Rohanda, Anis; Adrial, Hery; Bakhri, Syaiful; Sunaryo, Geni Rina

2018-02-01

In the Pebble-bed HTR reactor, the distance between the core and the reactor vessel is very close and the media inside are carbon and He gas. Neutron moderation capability of graphite material is theoretically lower than that of water-moderated reactors. Thus, it is estimated much more the fast neutrons will reach the reactor vessel. The fast neutron collisions with the atoms in the reactor vessel will result in radiation damage and could be reducing the vessel life. The purpose of this study was to obtain the magnitude of neutron fluence in the Pebble-bed HTR reactor vessel. Neutron fluence calculations in the pebble-bed HTR reactor vessel were performed using the MCNP computer program. By determining the tally position, it can be calculated flux, spectrum and neutron fluence in the position of Pebble-bed HTR reactor vessel. The calculations results of total neutron flux and fast neutron flux in the reactor vessel of 1.82x108 n/cm2/s and 1.79x108 n/cm2/s respectively. The fast neutron fluence in the reactor vessel is 3.4x1017 n/cm2 for 60 years reactor operation. Radiation damage in stainless steel material caused by high-energy neutrons (> 1.0 MeV) will occur when it has reached the neutron flux level of 1.0x1024 n/cm2. The neutron fluence results show that there is no radiation damage in the Pebble-bed HTR reactor vessel, so it is predicted that it will be safe to operate at least for 60 years.

33 CFR 401.3 - Maximum vessel dimensions.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 33 Navigation and Navigable Waters 3 2010-07-01 2010-07-01 false Maximum vessel dimensions. 401.3 Section 401.3 Navigation and Navigable Waters SAINT LAWRENCE SEAWAY DEVELOPMENT CORPORATION, DEPARTMENT OF TRANSPORTATION SEAWAY REGULATIONS AND RULES Regulations Condition of Vessels § 401.3 Maximum vessel dimensions...

The Assessment and Validation of Mini-Compact Tension Test Specimen Geometry and Progress in Establishing Technique for Fracture Toughness Master Curves for Reactor Pressure Vessel Steels

DOE Office of Scientific and Technical Information (OSTI.GOV)

Sokolov, Mikhail A.; Nanstad, Randy K.

Small specimens are playing the key role in evaluating properties of irradiated materials. The use of small specimens provides several advantages. Typically, only a small volume of material can be irradiated in a reactor at desirable conditions in terms of temperature, neutron flux, and neutron dose. A small volume of irradiated material may also allow for easier handling of specimens. Smaller specimens reduce the amount of radioactive material, minimizing personnel exposures and waste disposal. However, use of small specimens imposes a variety of challenges as well. These challenges are associated with proper accounting for size effects and transferability of smallmore » specimen data to the real structures of interest. Any fracture toughness specimen that can be made out of the broken halves of standard Charpy specimens may have exceptional utility for evaluation of reactor pressure vessels (RPVs) since it would allow one to determine and monitor directly actual fracture toughness instead of requiring indirect predictions using correlations established with impact data. The Charpy V-notch specimen is the most commonly used specimen geometry in surveillance programs. Assessment and validation of mini-CT specimen geometry has been performed on previously well characterized HSST Plate 13B, an A533B class 1 steel. It was shown that the fracture toughness transition temperature measured by these Mini-CT specimens is within the range of To values that were derived from various large fracture toughness specimens. Moreover, the scatter of the fracture toughness values measured by Mini-CT specimens perfectly follows the Weibull distribution function providing additional proof for validation of this geometry for the Master Curve evaluation of rector pressure vessel steels. Moreover, the International collaborative program has been developed to extend the assessment and validation efforts to irradiated weld metal. The program is underway and involves ORNL, CRIEPI, and EPRI.« less

40 CFR Table 5 to Subpart Jjj of... - Group 1 Storage Vessels at New Affected Sources Producing the Listed Thermoplastics

Code of Federal Regulations, 2010 CFR

2010-07-01

... 40 Protection of Environment 11 2010-07-01 2010-07-01 true Group 1 Storage Vessels at New Affected Sources Producing the Listed Thermoplastics 5 Table 5 to Subpart JJJ of Part 63 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR PROGRAMS (CONTINUED) NATIONAL EMISSION STANDARDS FOR HAZARDOUS AIR POLLUTANTS FOR SOURCE...

40 CFR Table 5 to Subpart Jjj of... - Group 1 Storage Vessels at New Affected Sources Producing the Listed Thermoplastics

Code of Federal Regulations, 2011 CFR

2011-07-01

... 40 Protection of Environment 11 2011-07-01 2011-07-01 false Group 1 Storage Vessels at New Affected Sources Producing the Listed Thermoplastics 5 Table 5 to Subpart JJJ of Part 63 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR PROGRAMS (CONTINUED) NATIONAL EMISSION STANDARDS FOR HAZARDOUS AIR POLLUTANTS FOR SOURCE...

40 CFR Table 5 to Subpart Jjj of... - Group 1 Storage Vessels at New Affected Sources Producing the Listed Thermoplastics

Code of Federal Regulations, 2014 CFR

2014-07-01

... 40 Protection of Environment 12 2014-07-01 2014-07-01 false Group 1 Storage Vessels at New Affected Sources Producing the Listed Thermoplastics 5 Table 5 to Subpart JJJ of Part 63 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR PROGRAMS (CONTINUED) NATIONAL EMISSION STANDARDS FOR HAZARDOUS AIR POLLUTANTS FOR SOURCE...

40 CFR Table 5 to Subpart Jjj of... - Group 1 Storage Vessels at New Affected Sources Producing the Listed Thermoplastics

Code of Federal Regulations, 2013 CFR

2013-07-01

... 40 Protection of Environment 12 2013-07-01 2013-07-01 false Group 1 Storage Vessels at New Affected Sources Producing the Listed Thermoplastics 5 Table 5 to Subpart JJJ of Part 63 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR PROGRAMS (CONTINUED) NATIONAL EMISSION STANDARDS FOR HAZARDOUS AIR POLLUTANTS FOR SOURCE...

40 CFR Table 5 to Subpart Jjj of... - Group 1 Storage Vessels at New Affected Sources Producing the Listed Thermoplastics

Code of Federal Regulations, 2012 CFR

2012-07-01

... 40 Protection of Environment 12 2012-07-01 2011-07-01 true Group 1 Storage Vessels at New Affected Sources Producing the Listed Thermoplastics 5 Table 5 to Subpart JJJ of Part 63 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR PROGRAMS (CONTINUED) NATIONAL EMISSION STANDARDS FOR HAZARDOUS AIR POLLUTANTS FOR SOURCE...

Status of the tokamak program

NASA Astrophysics Data System (ADS)

Sheffield, J.

1981-08-01

For a specific configuration of magnetic field and plasma to be economically attractive as a commercial source of energy, it must contain a high-pressure plasma in a stable fashion while thermally isolating the plasma from the walls of the containment vessel. The tokamak magnetic configuration is presently the most successful in terms of reaching the considered goals. Tokamaks were developed in the USSR in a program initiated in the mid-1950s. By the early 1970s tokamaks were operating not only in the USSR but also in the U.S., Australia, Europe, and Japan. The advanced state of the tokamak program is indicated by the fact that it is used as a testbed for generic fusion development - for auxiliary heating, diagnostics, materials - as well as for specific tokamak advancement. This has occurred because it is the most economic source of a large, reproducible, hot, dense plasma. The basic tokamak is considered along with tokamak improvements, impurity control, additional heating, particle and power balance in a tokamak, aspects of microscopic transport, and macroscopic stability.

Murray's Law in elastin haploinsufficient (Eln+/-) and wild-type (WT) mice.

PubMed

Sather, Bradley A; Hageman, Daniel; Wagenseil, Jessica E

2012-12-01

Using either the principle of minimum energy or constant shear stress, a relation can be derived that predicts the diameters of branching vessels at a bifurcation. This relation, known as Murray's Law, has been shown to predict vessel diameters in a variety of cardiovascular systems from adult humans to developing chicks. The goal of this study is to investigate Murray's Law in vessels from mice that are haploinsufficient for the elastin protein (Eln+/-). Elastin is one of the major proteins in the blood vessel wall and is organized in concentric rings, known as lamellae, with smooth muscle cells (SMCs) around the vessel lumen. Eln+/- mice have an increased number of lamellae, as well as smaller, thinner vessels. It is possible that due to decreased amounts of elastin available for vessel wall remodeling during development and in adulthood, Eln+/- vessels would not follow Murray's Law. We examined vessel bifurcations in six different physiologic regions, including the brain, heart, epidermis, ceocum (or cecum), testes, and intestines, in Eln+/- mice and wild-type (WT) littermates. All vessels were between 40 and 300 μm in diameter. We found that the diameters of both Eln+/- and WT vessels have an average of 13% error from the diameters predicted by Murray's Law, with no significant differences between genotypes or physiologic regions. The data suggest that vessels are optimized to follow Murray's Law, despite limitations on the proteins available for growth and remodeling of the vessel wall.

Likelihood of a marine vessel accident from wind energy development in the Atlantic: Likelihood of shipping accident from wind energy in the Atlantic

DOE Office of Scientific and Technical Information (OSTI.GOV)

Copping, Andrea; Breithaupt, Stephen; Whiting, Jonathan

2015-11-02

Offshore wind energy development is planned for areas off the Atlantic coast. Many of the planned wind development areas fall within traditional commercial vessel routes. In order to mitigate possible hazards to ships and to wind turbines, it is important to understand the potential for increased risk to commercial shipping from the presence of wind farms. Using Automatic Identification System (AIS) data, historical shipping routes between ports in the Atlantic were identified, from Maine to the Florida Straits. The AIS data were also used as inputs to a numerical model that can simulate cargo, tanker and tug/towing vessel movement alongmore » typical routes. The model was used to recreate present day vessel movement, as well as to simulate future routing that may be required to avoid wind farms. By comparing the present and future routing of vessels, a risk analysis was carried out to determine the increased marginal risk of vessel collisions, groundings, and allisions with stationary objects, due to the presence of wind farms. The outcome of the analysis showed little increase in vessel collisions or allisions, and a decrease in groundings as more vessels were forced seaward by the wind farms.« less

NBIC: Ballast Water Reporting Forms

Science.gov Websites

for the Coast Guard's Equivalent Reporting Program (ERP). The ERP program is restricted to NON regulations, submit a BWMR at least 24 hours before the vessel arrives in Montreal, Quebec. Non-US/non | FAQ| Equivalent Reporting Program Privacy policy - Terms of Use - Contact us: nbic@ballastreport.org

50 CFR 648.60 - Sea scallop access area program requirements.

Code of Federal Regulations, 2013 CFR

2013-10-01

... 50 Wildlife and Fisheries 12 2013-10-01 2013-10-01 false Sea scallop access area program... Management Measures for the Atlantic Sea Scallop Fishery § 648.60 Sea scallop access area program requirements. (a) A limited access scallop vessel may only fish in the Sea Scallop Access Areas specified in...

50 CFR 648.60 - Sea scallop access area program requirements.

Code of Federal Regulations, 2014 CFR

2014-10-01

... 50 Wildlife and Fisheries 12 2014-10-01 2014-10-01 false Sea scallop access area program... Management Measures for the Atlantic Sea Scallop Fishery § 648.60 Sea scallop access area program requirements. (a) A limited access scallop vessel may only fish in the Sea Scallop Access Areas specified in...

50 CFR 648.60 - Sea scallop area access program requirements.

Code of Federal Regulations, 2011 CFR

2011-10-01

... 50 Wildlife and Fisheries 10 2011-10-01 2011-10-01 false Sea scallop area access program... Management Measures for the Atlantic Sea Scallop Fishery § 648.60 Sea scallop area access program requirements. (a) A limited access scallop vessel may only fish in the Sea Scallop Access Areas specified in...

50 CFR 648.60 - Sea scallop access area program requirements.

Code of Federal Regulations, 2012 CFR

2012-10-01

... 50 Wildlife and Fisheries 12 2012-10-01 2012-10-01 false Sea scallop access area program... Management Measures for the Atlantic Sea Scallop Fishery § 648.60 Sea scallop access area program requirements. (a) A limited access scallop vessel may only fish in the Sea Scallop Access Areas specified in...

50 CFR 648.60 - Sea scallop area access program requirements.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 50 Wildlife and Fisheries 8 2010-10-01 2010-10-01 false Sea scallop area access program... Management Measures for the Atlantic Sea Scallop Fishery § 648.60 Sea scallop area access program requirements. (a) A limited access scallop vessel may only fish in the Sea Scallop Access Areas specified in...

46 CFR 71.50-19 - The Alternative Hull Examination (AHE) Program application.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 46 Shipping 3 2010-10-01 2010-10-01 false The Alternative Hull Examination (AHE) Program...) PASSENGER VESSELS INSPECTION AND CERTIFICATION Drydocking § 71.50-19 The Alternative Hull Examination (AHE... apply to the AHE Program. You must submit an application at least 90 days before the requested hull...

Free forming of the gel by 3D gel printer SWIM-ER

NASA Astrophysics Data System (ADS)

Okada, Koji; Tase, Taishi; Saito, Azusa; Makino, Masato; Gong, Jin; Kawakami, Masaru; Furukawa, Hidemitsu

2015-04-01

Gels, soft and wet materials, have unique properties such as material permeability, biocompatibility and low friction, which are hardly found in hard and dry materials. These superior characteristics of hydrogels promise to expand the medical applications. In recent years, the optical 3D gel printer named SWIM-ER (Soft and Wet Industrial - Easy Realizer) was developed by our team in order to fabricate tough gels with free form. We are aiming to create artificial blood vessel of the gel material by 3D gel printer. Artificial blood vessel is expected to be used for vascular surgery practice. The artificial blood vessel made by 3D gel printer can be create to free form on the basis of the biological data of the patient. Therefore, we believe it is possible to contribute to increasing the success rate and safety of vascular surgery by creating artificial blood vessel with 3D gel printer. The modeling method of SWIM-ER is as follow. Pregel solution is polymerized by one-point UV irradiation with optical fiber. The irradiation area is controlled by computer program, so that exact 3D free forming is realized. In this study, synthesis conditions are re-examined in order to improve the degree of freedom of fabrication. The dimensional accuracy in height direction is improved by increasing the cross linker concentration. We examined the relationship of resolution to the pitch and UV irradiation time in order to improve the modeling accuracy.

Maritime dynamic traffic generator : Volume II. Electronic data processing program.

DOT National Transportation Integrated Search

1975-06-01

The processor program is designed to move 18,000 merchant vessels along standard routes to their destination and keep statistical records of the ports visited, the five degree squares passed through and the occurrence of casualties. This document pre...

Tailoring vessel morphology in vivo

NASA Astrophysics Data System (ADS)

Gould, Daniel Joseph

Tissue engineering is a rapidly growing field which seeks to provide alternatives to organ transplantation in order to address the increasing need for transplantable tissues. One huge hurdle in this effort is the provision of thick tissues; this hurdle exists because currently there is no way to provide prevascularized or rapidly vascularizable scaffolds. To design thick, vascularized tissues, scaffolds are needed that can induce vessels which are similar to the microvasculature found in normal tissues. Angiogenic biomaterials are being developed to provide useful scaffolds to address this problem. In this thesis angiogenic and cell signaling and adhesion factors were incorporated into a biomimetic poly(ethylene glycol) (PEG) hydrogel system. The composition of these hydrogels was precisely tuned to induce the formation of differing vessel morphology. To sensitively measure induced microvascular morphology and to compare it to native microvessels in several tissues, this thesis developed an image-based tool for quantification of scale invariant and classical measures of vessel morphology. The tool displayed great utility in the comparison of native vessels and remodeling vessels in normal tissues. To utilize this tool to tune the vessel response in vivo, Flk1::myr-mCherry fluorescently labeled mice were implanted with Platelet Derived Growth Factor-BB (PDGF-BB) and basic Fibroblast Growth Factor (FGF-2) containing PEG-based hydrogels in a modified mouse corneal angiogenesis assay. Resulting vessels were imaged with confocal microscopy, analyzed with the image based tool created in this thesis to compare morphological differences between treatment groups, and used to create a linear relationship between space filling parameters and dose of growth factor release. Morphological parameters of native mouse tissue vessels were then compared to the linear fit to calculate the dose of growth factors needed to induce vessels similar in morphology to native vessels. Resulting induced vessels did match in morphology to the target vessels. Several other covalently bound signals were then analyzed in the assay and resulting morphology of vessels was compared in several studies which further highlighted the utility of the micropocket assay in conjunction with the image based tool for vessel morphological quantification. Finally, an alternative method to provide rapid vasculature to the constructs, which relied on pre-seeded hydrogels encapsulated endothelial cells was also developed and shown to allow anastamosis between induced host vessels and the implanted construct within 48 hours. These results indicate great promise in the rational design of synthetic, bioactive hydrogels, which can be used as a platform to study microvascular induction for regenerative medicine and angiogenesis research. Future applications of this research may help to develop therapeutic strategies to ameliorate human disease by replacing organs or correcting vessel morphology in the case of ischemic diseases and cancer.

Development of a Filament-Overwrapped Cryoformed Metal Pressure Vessel

DTIC Science & Technology

1971-01-01

ABSTRACT High performance ARDEFORM cryoformed 301 stainless steel glass fiber reinforced (GFR) vessels were demonstrated by room temperature tests of 13 1...Appendix 6 - Vessel Testing ........... . A-54 7.7 Appendix 7 - Increased Ductility Liner High Performance Spherical GFR Vessel A-62 7.8 Appendix 8...vessel consisting of a load-bearing cryogenically stretched ARDEFORM 301 stainless steel liner overwrapped with fiber- glass for high pressure fluid

Automatic lumen and outer wall segmentation of the carotid artery using deformable three-dimensional models in MR angiography and vessel wall images.

PubMed

van 't Klooster, Ronald; de Koning, Patrick J H; Dehnavi, Reza Alizadeh; Tamsma, Jouke T; de Roos, Albert; Reiber, Johan H C; van der Geest, Rob J

2012-01-01

To develop and validate an automated segmentation technique for the detection of the lumen and outer wall boundaries in MR vessel wall studies of the common carotid artery. A new segmentation method was developed using a three-dimensional (3D) deformable vessel model requiring only one single user interaction by combining 3D MR angiography (MRA) and 2D vessel wall images. This vessel model is a 3D cylindrical Non-Uniform Rational B-Spline (NURBS) surface which can be deformed to fit the underlying image data. Image data of 45 subjects was used to validate the method by comparing manual and automatic segmentations. Vessel wall thickness and volume measurements obtained by both methods were compared. Substantial agreement was observed between manual and automatic segmentation; over 85% of the vessel wall contours were segmented successfully. The interclass correlation was 0.690 for the vessel wall thickness and 0.793 for the vessel wall volume. Compared with manual image analysis, the automated method demonstrated improved interobserver agreement and inter-scan reproducibility. Additionally, the proposed automated image analysis approach was substantially faster. This new automated method can reduce analysis time and enhance reproducibility of the quantification of vessel wall dimensions in clinical studies. Copyright © 2011 Wiley Periodicals, Inc.

Approach for Configuring a Standardized Vessel for Processing Radioactive Waste Slurries

DOE Office of Scientific and Technical Information (OSTI.GOV)

Bamberger, Judith A.; Enderlin, Carl W.; Minette, Michael J.

2015-09-10

A standardized vessel design is being considered at the Waste Treatment and Immobilization Plant (WTP) that is under construction at Hanford, Washington. The standardized vessel design will be used for storing, blending, and chemical processing of slurries that exhibit a variable process feed including Newtonian to non-Newtonian rheologies over a range of solids loadings. Developing a standardized vessel is advantageous and reduces the testing required to evaluate the performance of the design. The objectives of this paper are to: 1) present a design strategy for developing a standard vessel mixing system design for the pretreatment portion of the waste treatmentmore » plant that must process rheologically and physically challenging process streams, 2) identify performance criteria that the design for the standard vessel must satisfy, 3) present parameters that are to be used for assessing the performance criteria, and 4) describe operation of the selected technology. Vessel design performance will be assessed for both Newtonian and non-Newtonian simulants which represent a range of waste types expected during operation. Desired conditions for the vessel operations are the ability to shear the slurry so that flammable gas does not accumulate within the vessel, that settled solids will be mobilized, that contents can be blended, and that contents can be transferred from the vessel. A strategy is presented for adjusting the vessel configuration to ensure that all these conditions are met.« less

SURROGATE MODEL DEVELOPMENT AND VALIDATION FOR RELIABILITY ANALYSIS OF REACTOR PRESSURE VESSELS

DOE Office of Scientific and Technical Information (OSTI.GOV)

Hoffman, William M.; Riley, Matthew E.; Spencer, Benjamin W.

In nuclear light water reactors (LWRs), the reactor coolant, core and shroud are contained within a massive, thick walled steel vessel known as a reactor pressure vessel (RPV). Given the tremendous size of these structures, RPVs typically contain a large population of pre-existing flaws introduced in the manufacturing process. After many years of operation, irradiation-induced embrittlement makes these vessels increasingly susceptible to fracture initiation at the locations of the pre-existing flaws. Because of the uncertainty in the loading conditions, flaw characteristics and material properties, probabilistic methods are widely accepted and used in assessing RPV integrity. The Fracture Analysis of Vesselsmore » – Oak Ridge (FAVOR) computer program developed by researchers at Oak Ridge National Laboratory is widely used for this purpose. This program can be used in order to perform deterministic and probabilistic risk-informed analyses of the structural integrity of an RPV subjected to a range of thermal-hydraulic events. FAVOR uses a one-dimensional representation of the global response of the RPV, which is appropriate for the beltline region, which experiences the most embrittlement, and employs an influence coefficient technique to rapidly compute stress intensity factors for axis-aligned surface-breaking flaws. The Grizzly code is currently under development at Idaho National Laboratory (INL) to be used as a general multiphysics simulation tool to study a variety of degradation mechanisms in nuclear power plant components. The first application of Grizzly has been to study fracture in embrittled RPVs. Grizzly can be used to model the thermo-mechanical response of an RPV under transient conditions observed in a pressurized thermal shock (PTS) scenario. The global response of the vessel provides boundary conditions for local 3D models of the material in the vicinity of a flaw. Fracture domain integrals are computed to obtain stress intensity factors, which can in turn be used to assess whether a fracture would initiate at a pre-existing flaw. To use Grizzly for probabilistic analysis, it is necessary to have a way to rapidly evaluate stress intensity factors. To accomplish this goal, a reduced order model (ROM) has been developed to efficiently represent the behavior of a detailed 3D Grizzly model used to calculate fracture parameters. This approach uses the stress intensity factor influence coefficient method that has been used with great success in FAVOR. Instead of interpolating between tabulated solutions, as FAVOR does, the ROM approach uses a response surface methodology to compute fracture solutions based on a sampled set of results used to train the ROM. The main advantages of this approach are that the process of generating the training data can be fully automated, and the procedure can be readily used to consider more general flaw configurations. This paper demonstrates the procedure used to generate a ROM to rapidly compute stress intensity factors for axis-aligned flaws. The results from this procedure are in good agreement with those produced using the traditional influence coefficient interpolation procedure, which gives confidence in this method. This paves the way for applying this procedure for more general flaw configurations.« less

Current status and future R&D for reduced-activation ferritic/martensitic steels

NASA Astrophysics Data System (ADS)

Hishinuma, A.; Kohyama, A.; Klueh, R. L.; Gelles, D. S.; Dietz, W.; Ehrlich, K.

1998-10-01

International research and development programs on reduced-activation ferritic/martensitic steels, the primary candidate-alloys for a DEMO fusion reactor and beyond, are briefly summarized, along with some information on conventional steels. An International Energy Agency (IEA) collaborative test program to determine the feasibility of reduced-activation ferritic/martensitic steels for fusion is in progress and will be completed within this century. Baseline properties including typical irradiation behavior for Fe-(7-9)%Cr reduced-activation ferritic steels are shown. Most of the data are for a heat of modified F82H steel, purchased for the IEA program. Experimental plans to explore possible problems and solutions for fusion devices using ferromagnetic materials are introduced. The preliminary results show that it should be possible to use a ferromagnetic vacuum vessel in tokamak devices.

Heterogeneity of the tumor vasculature.

PubMed

Nagy, Janice A; Chang, Sung-Hee; Shih, Shou-Ching; Dvorak, Ann M; Dvorak, Harold F

2010-04-01

The blood vessels supplying tumors are strikingly heterogeneous and differ from their normal counterparts with respect to organization, structure, and function. Six distinctly different tumor vessel types have been identified, and much has been learned about the steps and mechanisms by which they form. Four of the six vessel types (mother vessels, capillaries, glomeruloid microvascular proliferations, and vascular malformations) develop from preexisting normal venules and capillaries by angiogenesis. The two remaining vessel types (feeder arteries and draining veins) develop from arterio-venogenesis, a parallel, poorly understood process that involves the remodeling of preexisting arteries and veins. All six of these tumor vessel types can be induced to form sequentially in normal mouse tissues by an adenoviral vector expressing vascular endothelial growth factor (VEGF)-A164. Current antiangiogenic cancer therapies directed at VEGF-A or its receptors have been of only limited benefit to cancer patients, perhaps because they target only the endothelial cells of the tumor blood vessel subset that requires exogenous VEGF-A for maintenance. A goal of future work is to identify therapeutic targets on tumor blood vessel endothelial cells that have lost this requirement. Thieme Medical Publishers.

Heterogeneity of the Tumor Vasculature

PubMed Central

Nagy, Janice A.; Chang, Sung-Hee; Shih, Shou-Ching; Dvorak, Ann M.; Dvorak, Harold F.

2012-01-01

The blood vessels supplying tumors are strikingly heterogeneous and differ from their normal counterparts with respect to organization, structure, and function. Six distinctly different tumor vessel types have been identified, and much has been learned about the steps and mechanisms by which they form. Four of the six vessel types (mother vessels, capillaries, glomeruloid microvascular proliferations, and vascular malformations) develop from preexisting normal venules and capillaries by angiogenesis. The two remaining vessel types (feeder arteries and draining veins) develop from arterio-venogenesis, a parallel, poorly understood process that involves the remodeling of preexisting arteries and veins. All six of these tumor vessel types can be induced to form sequentially in normal mouse tissues by an adenoviral vector expressing vascular endothelial growth factor (VEGF)-A164. Current antiangiogenic cancer therapies directed at VEGF-A or its receptors have been of only limited benefit to cancer patients, perhaps because they target only the endothelial cells of the tumor blood vessel subset that requires exogenous VEGF-A for maintenance. A goal of future work is to identify therapeutic targets on tumor blood vessel endothelial cells that have lost this requirement. PMID:20490982

Maritime Route Delineation using AIS Data from the Atlantic Coast of the US

DOE Office of Scientific and Technical Information (OSTI.GOV)

Breithaupt, Stephen A.; Copping, Andrea; Tagestad, Jerry

2016-09-28

This study examines maritime routes between ports along the Atlantic coast of the US, utilising Automated Identification System (AIS) data for the years 2010 through 2012. The delineation of vessel routes conducted in this study was motivated by development planned for offshore Wind Energy Areas (WEAs) along the Atlantic coast of the US and the need to evaluate the effect of these development areas on commercial shipping. To this end, available AIS data were processed to generate commercial vessel tracks for individual vessels, though cargo vessels are the focus in this study. The individual vessel tracks were sampled at transectsmore » placed along the Atlantic coast. The transect samples were analysed and partitioned by voyages between Atlantic ports to facilitate computation of vessel routes between ports. The route boundary analysis utilised a definition from UK guidance in which routes' boundaries encompassed 95% of the vessel traffic between ports. In addition to delineating route boundaries, we found multi-modal transverse distributions of vessels for well-travelled routes, which indicated preference for lanes of travel within the delineated routes.« less

In-vessel melt retention as a severe accident management strategy for the Loviisa Nuclear Power Plant

DOE Office of Scientific and Technical Information (OSTI.GOV)

Kymaelaeinen, O.; Tuomisto, H.; Theofanous, T.G.

1997-02-01

The concept of lower head coolability and in-vessel retention of corium has been approved as a basic element of the severe accident management strategy for IVO`s Loviisa Plant (VVER-440) in Finland. The selected approach takes advantage of the unique features of the plant such as low power density, reactor pressure vessel without penetrations at the bottom and ice-condenser containment which ensures flooded cavity in all risk significant sequences. The thermal analyses, which are supported by experimental program, demonstrate that in Loviisa the molten corium on the lower head of the reactor vessel is coolable externally with wide margins. This papermore » summarizes the approach and the plant modifications being implemented. During the approval process some technical concerns were raised, particularly with regard to thermal loadings caused by contact of cool cavity water and hot corium with the reactor vessel. Resolution of these concerns is also discussed.« less

Experimental Investigation of Composite Pressure Vessel Performance and Joint Stiffness for Pyramid and Inverted Pyramid Joints

NASA Technical Reports Server (NTRS)

Verhage, Joseph M.; Bower, Mark V.; Gilbert, Paul A. (Technical Monitor)

2001-01-01

The focus of this study is on the suitability in the application of classical laminate theory analysis tools for filament wound pressure vessels with adhesive laminated joints in particular: pressure vessel wall performance, joint stiffness and failure prediction. Two 18-inch diameter 12-ply filament wound pressure vessels were fabricated. One vessel was fabricated with a 24-ply pyramid laminated adhesive double strap butt joint. The second vessel was fabricated with the same number of plies in an inverted pyramid joint. Results from hydrostatic tests are presented. Experimental results were used as input to the computer programs GENLAM and Laminate, and the output compared to test. By using the axial stress resultant, the classical laminate theory results show a correlation within 1% to the experimental results in predicting the pressure vessel wall pressure performance. The prediction of joint stiffness for the two adhesive joints in the axial direction is within 1% of the experimental results. The calculated hoop direction joint stress resultant is 25% less than the measured resultant for both joint configurations. A correction factor is derived and used in the joint analysis. The correction factor is derived from the hoop stress resultant from the tank wall performance investigation. The vessel with the pyramid joint is determined to have failed in the joint area at a hydrostatic pressure 33% value below predicted failure. The vessel with the inverted pyramid joint failed in the wall acreage at a hydrostatic pressure within 10% of the actual failure pressure.

NASA Requirements for Ground-Based Pressure Vessels and Pressurized Systems (PVS). Revision C

NASA Technical Reports Server (NTRS)

Greulich, Owen Rudolf

2017-01-01

The purpose of this document is to ensure the structural integrity of PVS through implementation of a minimum set of requirements for ground-based PVS in accordance with this document, NASA Policy Directive (NPD) 8710.5, NASA Safety Policy for Pressure Vessels and Pressurized Systems, NASA Procedural Requirements (NPR) 8715.3, NASA General Safety Program Requirements, applicable Federal Regulations, and national consensus codes and standards (NCS).

Scenario based optimization of a container vessel with respect to its projected operating conditions

NASA Astrophysics Data System (ADS)

Wagner, Jonas; Binkowski, Eva; Bronsart, Robert

2014-06-01

In this paper the scenario based optimization of the bulbous bow of the KRISO Container Ship (KCS) is presented. The optimization of the parametrically modeled vessel is based on a statistically developed operational profile generated from noon-to-noon reports of a comparable 3600 TEU container vessel and specific development functions representing the growth of global economy during the vessels service time. In order to consider uncertainties, statistical fluctuations are added. An analysis of these data lead to a number of most probable upcoming operating conditions (OC) the vessel will stay in the future. According to their respective likeliness an objective function for the evaluation of the optimal design variant of the vessel is derived and implemented within the parametrical optimization workbench FRIENDSHIP Framework. In the following this evaluation is done with respect to vessel's calculated effective power based on the usage of potential flow code. The evaluation shows, that the usage of scenarios within the optimization process has a strong influence on the hull form.

A Navigation Safety Support Model for the Strait of Istanbul

NASA Astrophysics Data System (ADS)

Yazici, M. Anil; Otay, Emre N.

In this study, a real time maritime traffic support model is developed for safe navigation in the Strait of Istanbul, also known as the Bosporus. The present model simulates vessel trajectories corresponding to possible headings, using channel geometry, counter traffic, and surface currents as input. A new MATLAB code is developed for the simulation and the Marine GNC Toolbox (Fossen and Perez, 2004) is used for the vessel hydrodynamics and the auto-pilot model. After computing the trajectory tree of the vessel by forward-mapping its position distribution with respect to the initial position vector, the casualty probabilities of each trajectory are found. Within certain restrictions on vessel geometry, the proposed model predicts the safest possible intended course for the transit vessels based on the navigational parameters including position, speed, and course of the vessel. The model is tested for the Strait of Istanbul for validation. Without loss of generality, the model can be used for any narrow channel with a vessel traffic system providing the necessary input.

BOILING HEAT TRANSFER IN ZERO GRAVITY

DOE Office of Scientific and Technical Information (OSTI.GOV)

Zara, E.A.

1964-01-01

The preliminary results of a research program to determine the effects of zero and near zero gravity on boiling heat transfer are presented. Zero gravity conditions were obtained on the ASD KC-135 zero gravity test aircraft, capable of providing 30-seconds of zero gravity. Results of the program to date indicate that nucleate (bubble) boiling heat transfer rates are not greatly affected by the absence of gravity forces. However, radical pressure increases were observed that will dictate special design considerations to space vehicle systems utilizing pool boiling processes, such as cryogenic or other fluid storage vessels where thermal input to themore » fluid is used for vessel pressurization. (auth)« less

A simplified, low power system for effective vessel sealing

NASA Astrophysics Data System (ADS)

Lyle, Allison B.; Kennedy, Jenifer S.; Schmaltz, Dale F.; Kennedy, Aaron S.

2015-03-01

The first bipolar vessel sealing system was developed nearly 15 years ago and has since become standard of care in surgery. These systems make use of radio frequency current that is delivered between bipolar graspers to permanently seal arteries, veins and tissue bundles. Conventional vessel sealing generators are based off traditional electrosurgery generator architecture and deliver high power (150-300 Watts) and high current using complex control and sense algorithms to adjust the output for vessel sealing applications. In recent years, a need for small-scale surgical vessel sealers has developed as surgeons strive to further reduce their footprint on patients. There are many technical challenges associated with miniaturization of vessel sealing devices including maintaining electrical isolation while delivering high current in a saline environment. Research into creating a small, 3mm diameter vessel sealer revealed that a highly simplified generator system could be used to achieve excellent results and subsequently a low power vessel sealing system was developed. This system delivers 25 Watts constant power while limiting voltage (<= Vrms) and current (<= Amps) until an impedance endpoint is achieved, eliminating the use of complicated control and sensing software. The result is optimized tissue effect, where high seal strength is maintained (> 360mmHg), but seal times (1.7 +/- 0.7s versus 4.1 +/- 0.7s), thermal spread (<1mm vs <=2mm) and total energy delivery are reduced, when compared to an existing high power system.

NEURONAL ACTION ON THE DEVELOPING BLOOD VESSEL PATTERN

PubMed Central

James, Jennifer M.; Mukouyama, Yoh-suke

2011-01-01

The nervous system relies on a highly specialized network of blood vessels for development and neuronal survival. Recent evidence suggests that both the central and peripheral nervous systems (CNS and PNS) employ multiple mechanisms to shape the vascular tree to meet its specific metabolic demands, such as promoting nerve-artery alignment in the PNS or the development the blood brain barrier in the CNS. In this article we discuss how the nervous system directly influences blood vessel patterning resulting in neuro-vascular congruence that is maintained throughout development and in the adult. PMID:21978864

Bone Marrow Stromal Cells Stimulate an Angiogenic Program that Requires Endothelial MT1-MMP

PubMed Central

Kachgal, Suraj; Carrion, Bita; Janson, Isaac A.; Putnam, Andrew J.

2012-01-01

Bone marrow-derived stromal/stem cells (BMSCs) have recently been characterized as mediators of tissue regeneration after injury. In addition to preventing fibrosis at the wound site, BMSCs elicit an angiogenic response within the fibrin matrix. The mechanistic interactions between BMSCs and invading endothelial cells (ECs) during this process are not fully understood. Using a three-dimensional, fibrin-based angiogenesis model, we sought to investigate the proteolytic mechanisms by which BMSCs promote vessel morphogenesis. We find that BMSC-mediated vessel formation depends on the proteolytic ability of membrane type 1-matrix metalloproteinase (MT1-MMP). Knockdown of the protease results in a small network of vessels with enlarged lumens. Contrastingly, vessel morphogenesis is unaffected by the knockdown of MMP-2 and MMP-9. Furthermore, we find that BMSC-mediated vessel morphogenesis in vivo follows mechanisms similar to what we observe in vitro. Subcutaneous, cellular fibrin implants in C.B-17/SCID mice form aberrant vasculature when MMPs are inhibited with a broad spectrum chemical inhibitor, and a very minimal amount of vessels when MT1-MMP proteolytic activity is interrupted in ECs. Other studies have debated the necessity of MT1-MMP in the context of vessel invasion in fibrin, but this study clearly demonstrates its requirement in BMSC-mediated angiogenesis. PMID:22262018

Vascular endothelial growth factor signaling regulates the segregation of artery and vein via ERK activity during vascular development

DOE Office of Scientific and Technical Information (OSTI.GOV)

Kim, Se-Hee; Schmitt, Christopher E.; Woolls, Melissa J.

Highlights: ► VEGF-A signaling regulates the segregation of axial vessels. ► VEGF-A signaling is mediated by PKC and ERK in this process. ► Ectopic activation of ERK is sufficient to rescue defects in vessel segregation. -- Abstract: Segregation of two axial vessels, the dorsal aorta and caudal vein, is one of the earliest patterning events occur during development of vasculature. Despite the importance of this process and recent advances in our understanding on vascular patterning during development, molecular mechanisms that coordinate the segregation of axial vessels remain largely elusive. In this report, we find that vascular endothelial growth factor-A (Vegf-A)more » signaling regulates the segregation of dorsal aorta and axial vein during development. Inhibition of Vegf-A pathway components including ligand Vegf-A and its cognate receptor Kdrl, caused failure in segregation of axial vessels in zebrafish embryos. Similarly, chemical inhibition of Mitogen-activated protein kinase kinase (Map2k1)/Extracellular-signal-regulated kinases (Erk) and phosphatidylinositol 3-kinases (PI3 K), which are downstream effectors of Vegf-A signaling pathway, led to the fusion of two axial vessels. Moreover, we find that restoring Erk activity by over-expression of constitutively active MEK in embryos with a reduced level of Vegf-A signaling can rescue the defects in axial vessel segregation. Taken together, our data show that segregation of axial vessels requires the function of Vegf-A signaling, and Erk may function as the major downstream effector in this process.« less

Predicting Structural Behavior of Filament Wound Composite Pressure Vessel Using Three Dimensional Shell Analysis

NASA Astrophysics Data System (ADS)

Madhavi, M.; Venkat, R.

2014-01-01

Fiber reinforced polymer composite materials with their higher specific strength, moduli and tailorability characteristics will result in reduction of weight of the structure. The composite pressure vessels with integrated end domes develop hoop stresses that are twice longitudinal stresses and when isotropic materials like metals are used for development of the hardware and the material is not fully utilized in the longitudinal/meridional direction resulting in over weight components. The determination of a proper winding angles and thickness is very important to decrease manufacturing difficulties and to increase structural efficiency. In the present study a methodology is developed to understand structural characteristics of filament wound pressure vessels with integrated end domes. Progressive ply wise failure analysis of composite pressure vessel with geodesic end domes is carried out to determine matrix crack failure, burst pressure values at various positions of the shell. A three dimensional finite element analysis is computed to predict the deformations and stresses in the composite pressure vessel. The proposed method could save the time to design filament wound structures, to check whether the ply design is safe for the given input conditions and also can be adapted to non-geodesic structures. The results can be utilized to understand structural characteristics of filament wound pressure vessels with integrated end domes. This approach can be adopted for various applications like solid rocket motor casings, automobile fuel storage tanks and chemical storage tanks. Based on the predictions a composite pressure vessel is designed and developed. Hydraulic test is performed on the composite pressure vessel till the burst pressure.

Effect of Microgravity on Material Undergoing Melting and Freezing: the TES Experiment

NASA Technical Reports Server (NTRS)

Namkoong, David; Jacqmin, David; Szaniszlo, Andrew

1995-01-01

This experiment is the first to melt and freeze a high temperature thermal energy storage (TES) material under an extended duration of microgravity. It is one of a series to validate an analytical computer program that predicts void behavior of substances undergoing phase change under microgravity. Two flight experiments were launched in STS-62. The first, TES-1, containing lithium fluoride in an annular volume, performed flawlessly in the 22 hours of its operation. Results are reported in this paper. A software failure in TES-2 caused its shutdown after 4 seconds. A computer program, TESSIM, for thermal energy storage simulation is being developed to analyze the phenomena occurring within the TES containment vessel. The first order effects, particularly the surface tension forces, have been incorporated into TESSIM. TESSIM validation is based on two types of results. First is the temperature history of various points of the containment structure, and second, upon return from flight, the distribution of the TES material within the containment vessel following the last freeze cycle. The temperature data over the four cycles showed a repetition of results over the third and fourth cycles. This result is a confirmation that any initial conditions prior to the first cycle had been damped out by the third cycle. The TESSIM simulation showed a close comparison with the flight data. The solidified TES material distribution within the containment vessel was obtained by a tomography imaging process. The frozen material was concentrated toward the colder end of the annular volume. The TESSIM prediction showed the same pattern. With the general agreement of TESSIM and the data, a computerized visual representation can be shown which accurately shows the movement and behavior of the void during the entire freezing and melting cycles.

Effect of microgravity on material undergoing melting and freezing: The TES Experiment

NASA Astrophysics Data System (ADS)

Namkoong, David; Jacqmin, David; Szaniszlo, Andrew

1995-01-01

This experiment is the first to melt and freeze a high temperature thermal energy storage (TES) material under an extended duration of microgravity. It is one of a series to validate an analytical computer program that predicts void behavior of substances undergoing phase change under microgravity. Two flight experiments were launched in STS-62. The first, TES-1, containing lithium fluoride in an annular volume, performed flawlessly in the 22 hours of its operation. Results are reported in this paper. A software failure in TES-2 caused its shutdown after 4 seconds. A computer program, TESSIM, for thermal energy storage simulation is being developed to analyze the phenomena occurring within the TES containment vessel. The first order effects, particularly the surface tension forces, have been incorporated into TESSIM. TESSIM validation is based on two types of results. First is the temperature history of various points of the containment structure, and second, upon return from flight, the distribution of the TES material within the containment vessel following the last freeze cycle. The temperature data over the four cycles showed a repetition of results over the third and fourth cycles. This result is a confirmation that any initial conditions prior to the first cycle had been damped out by the third cycle. The TESSIM simulation showed a close comparison with the flight data. The solidified TES material distribution within the containment vessel was obtained by a tomography imaging process. The frozen material was concentrated toward the colder end of the annular volume. The TESSIM prediction showed the same pattern. With the general agreement of TESSIM and the data, a computerized visual representation can be shown which accurately shows the movement and behavior of the void during the entire freezing and melting cycles.

Artificial Intelligence Techniques for the Berth Allocation and Container Stacking Problems in Container Terminals

NASA Astrophysics Data System (ADS)

Salido, Miguel A.; Rodriguez-Molins, Mario; Barber, Federico

The Container Stacking Problem and the Berth Allocation Problem are two important problems in maritime container terminal's management which are clearly related. Terminal operators normally demand all containers to be loaded into an incoming vessel should be ready and easily accessible in the terminal before vessel's arrival. Similarly, customers (i.e., vessel owners) expect prompt berthing of their vessels upon arrival. In this paper, we present an artificial intelligence based-integrated system to relate these problems. Firstly, we develop a metaheuristic algorithm for berth allocation which generates an optimized order of vessel to be served according to existing berth constraints. Secondly, we develop a domain-oriented heuristic planner for calculating the number of reshuffles needed to allocate containers in the appropriate place for a given berth ordering of vessels. By combining these optimized solutions, terminal operators can be assisted to decide the most appropriated solution in each particular case.

40 CFR 270.60 - Permits by rule.

Code of Federal Regulations, 2010 CFR

2010-07-01

... Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) SOLID WASTES (CONTINUED) EPA ADMINISTERED PERMIT PROGRAMS: THE HAZARDOUS WASTE PERMIT PROGRAM Special Forms of Permits § 270.60 Permits by... operator of a barge or other vessel which accepts hazardous waste for ocean disposal, if the owner or...

40 CFR 270.60 - Permits by rule.

Code of Federal Regulations, 2011 CFR

2011-07-01

... Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) SOLID WASTES (CONTINUED) EPA ADMINISTERED PERMIT PROGRAMS: THE HAZARDOUS WASTE PERMIT PROGRAM Special Forms of Permits § 270.60 Permits by... operator of a barge or other vessel which accepts hazardous waste for ocean disposal, if the owner or...

31 CFR Appendixes to Chapter V - Note

Code of Federal Regulations, 2010 CFR

2010-07-01

.... Freight forwarders and shippers may not charter, book cargo on, or otherwise deal with blocked vessels. 7. References to regulatory parts in chapter V or other authorities: [BALKANS]: Western Balkans Stabilization... the economic sanctions programs in chapter V. (Please call OFAC Compliance Programs Division for...

NW-MILO Acoustic Data Collection

DOE Office of Scientific and Technical Information (OSTI.GOV)

Matzner, Shari; Myers, Joshua R.; Maxwell, Adam R.

2010-02-17

There is an enduring requirement to improve our ability to detect potential threats and discriminate these from the legitimate commercial and recreational activity ongoing in the nearshore/littoral portion of the maritime domain. The Northwest Maritime Information and Littoral Operations (NW-MILO) Program at PNNL’s Coastal Security Institute in Sequim, Washington is establishing a methodology to detect and classify these threats - in part through developing a better understanding of acoustic signatures in a near-shore environment. The purpose of the acoustic data collection described here is to investigate the acoustic signatures of small vessels. The data is being recorded continuously, 24 hoursmore » a day, along with radar track data and imagery. The recording began in August 2008, and to date the data contains tens of thousands of signals from small vessels recorded in a variety of environmental conditions. The quantity and variety of this data collection, with the supporting imagery and radar track data, makes it particularly useful for the development of robust acoustic signature models and advanced algorithms for signal classification and information extraction. The underwater acoustic sensing system is part of a multi-modal sensing system that is operating near the mouth of Sequim Bay. Sequim Bay opens onto the Straight of Juan de Fuca, which contains part of the border between the U.S. and Canada. Table 1 lists the specific components used for the NW-MILO system. The acoustic sensor is a hydrophone permanently deployed at a mean depth of about 3 meters. In addition to a hydrophone, the other sensors in the system are a marine radar, an electro-optical (EO) camera and an infra-red (IR) camera. The radar is integrated with a vessel tracking system (VTS) that provides position, speed and heading information. The data from all the sensors is recorded and saved to a central server. The data has been validated in terms of its usability for characterizing the signatures of small vessels. The sampling rate of 8 kHz and low pass filtering to 2 kHz results in an alias-free signal in the frequency band that is appropriate for small vessels. Calibration was performed using a Lubell underwater speaker so that the raw data signal levels can be converted to sound pressure. Background noise is present due to a nearby pump and as a result of tidal currents. More study is needed to fully characterize the noise, but it does not pose an obstacle to using the acoustic data for the purposes of vessel detection and signature analysis. The detection range for a small vessel was estimated using the calibrated voltage response of the system and a cylindrical spreading model for transmission loss. The sound pressure of a typical vessel with an outboard motor was found to be around 140 dB mPa, and could theoretically be detected from 10 km away. In practical terms, a small vessel could reliably be detected from 3 - 5 km away. The data is archived in netCDF files, a standard scientific file format that is "self describing". This means that each data file contains the metadata - timestamps, units, origin, etc. - needed to make the data meaningful and portable. Other file formats, such as XML, are also supported. A visualization tool has been developed to view the acoustic data in the form of spectrograms, along with the coincident radar track data and camera images.« less

Key findings and remaining questions in the areas of core-concrete interaction and debris coolability

DOE PAGES

Farmer, M. T.; Gerardi, C.; Bremer, N.; ...

2016-10-31

The reactor accidents at Fukushima-Dai-ichi have rekindled interest in late phase severe accident behavior involving reactor pressure vessel breach and discharge of molten core melt into the containment. Two technical issues of interest in this area include core-concrete interaction and the extent to which the core debris may be quenched and rendered coolable by top flooding. The OECD-sponsored Melt Coolability and Concrete Interaction (MCCI) programs at Argonne National Laboratory included the conduct of large scale reactor material experiments and associated analysis with the objectives of resolving the ex-vessel debris coolability issue, and to address remaining uncertainties related to long-term two-dimensionalmore » molten core-concrete interactions under both wet and dry cavity conditions. These tests provided a broad database to support accident management planning, as well as the development and validation of models and codes that can be used to extrapolate the experiment results to plant conditions. This paper provides a high level overview of the key experiment results obtained during the program. Finally, a discussion is also provided that describes technical gaps that remain in this area, several of which have arisen based on the sequence of events and operator actions during Fukushima.« less

Key findings and remaining questions in the areas of core-concrete interaction and debris coolability

DOE Office of Scientific and Technical Information (OSTI.GOV)

Farmer, M. T.; Gerardi, C.; Bremer, N.

The reactor accidents at Fukushima-Dai-ichi have rekindled interest in late phase severe accident behavior involving reactor pressure vessel breach and discharge of molten core melt into the containment. Two technical issues of interest in this area include core-concrete interaction and the extent to which the core debris may be quenched and rendered coolable by top flooding. The OECD-sponsored Melt Coolability and Concrete Interaction (MCCI) programs at Argonne National Laboratory included the conduct of large scale reactor material experiments and associated analysis with the objectives of resolving the ex-vessel debris coolability issue, and to address remaining uncertainties related to long-term two-dimensionalmore » molten core-concrete interactions under both wet and dry cavity conditions. These tests provided a broad database to support accident management planning, as well as the development and validation of models and codes that can be used to extrapolate the experiment results to plant conditions. This paper provides a high level overview of the key experiment results obtained during the program. Finally, a discussion is also provided that describes technical gaps that remain in this area, several of which have arisen based on the sequence of events and operator actions during Fukushima.« less

DR HAGIS-a fundus image database for the automatic extraction of retinal surface vessels from diabetic patients.

PubMed

Holm, Sven; Russell, Greg; Nourrit, Vincent; McLoughlin, Niall

2017-01-01

A database of retinal fundus images, the DR HAGIS database, is presented. This database consists of 39 high-resolution color fundus images obtained from a diabetic retinopathy screening program in the UK. The NHS screening program uses service providers that employ different fundus and digital cameras. This results in a range of different image sizes and resolutions. Furthermore, patients enrolled in such programs often display other comorbidities in addition to diabetes. Therefore, in an effort to replicate the normal range of images examined by grading experts during screening, the DR HAGIS database consists of images of varying image sizes and resolutions and four comorbidity subgroups: collectively defined as the diabetic retinopathy, hypertension, age-related macular degeneration, and Glaucoma image set (DR HAGIS). For each image, the vasculature has been manually segmented to provide a realistic set of images on which to test automatic vessel extraction algorithms. Modified versions of two previously published vessel extraction algorithms were applied to this database to provide some baseline measurements. A method based purely on the intensity of images pixels resulted in a mean segmentation accuracy of 95.83% ([Formula: see text]), whereas an algorithm based on Gabor filters generated an accuracy of 95.71% ([Formula: see text]).

Offshore wind development research (technical brief).

DOT National Transportation Integrated Search

2014-04-01

The study addresses all aspects of Offshore Wind (OSW) development. This includes identifying : vessel types, vessel installation methods, needs and operating characteristics through all phases : of OSW installation, construction, operations and main...

Containment Prospectus for the TRUMPET Experiments

DOE Office of Scientific and Technical Information (OSTI.GOV)

Pawloski, G A

2004-02-05

TRUMPET is a series of dynamic subcritical experiments planned for execution in the U1a.102D alcove of the U1a Complex at the Nevada Test Site (NTS). The location of LLNL drifts at the U1a Complex is shown in Figure 1. The data from the TRUMPET experiments will be used in the Stockpile Stewardship Program to assess the aging of nuclear weapons components and to better model the long-term performance of weapons in the enduring stockpile. The TRUMPET series of experiments will be conducted in an almost identical way as the OBOE series of experiments. Individual TRUMPET experiments will be housed inmore » an experiment vessel, as was done for OBOE. These vessels are the same as those utilized for OBOE. All TRUMPET experiments will occur in the zero room in the U1a.102D alcove, which is on the opposite side of the U1a.102 drift from U1a.102C, which housed the OBOE experiments. The centerlines of these two alcoves are separated by only 10 feet. As with OBOE experiments, expended TRUMPET experiment vessels will be moved to the back of the alcove and entombed in grout. After the TRUMPET series of experiments is completed, another experiment will be sited in the U1a.102D alcove and it will be the final experiment in the zero room, as was similarly done for the OBOE series of experiments followed by the execution of the PIANO experiment. Each experimental package for TRUMPET will be composed of high explosive (HE) and special nuclear material (SNM) in a subcritical assembly. Each experimental package will be placed in an experimental vessel within the TRUMPET zero room in the U1a.102D alcove. The containment plan for the TRUMPET experiments utilizes a two-nested containment vessel concept, similar to OBOE and other subcritical experiments in the U1a Complex. The first containment vessel is formed by the primary containment barrier that seals the U1a.102D drift. The second containment vessel is formed by the secondary containment barrier in the U1a.100 drift. While it is likely that the experiment vessel will contain the SNM from the experiment, the containment plan for the TRUMPET experiments only assumes that the experiment vessel provides shock mitigation and serves as a sink for the heat produced by the detonation of the HE. It is possible that one or more of the experiment vessels may seep SNM into the zero room from a failure of a seal on the vessel. This containment plan covers the entire series of TRUMPET experiments. At this time, we don't know exactly how many experiments will actually be conducted in the TRUMPET series. However, we know that the maximum planned number of experiments in the TRUMPET series is 20. This number may be modified on the basis of results obtained from each TRUMPET experiment. After the final experiment in the TRUMPET series is completed, a larger experiment will be conducted in the U1a.102D alcove. A separate containment plan will be developed and presented to the Containment Review Panel (CRP) for that larger experiment. As with OBOE, this containment plan is intended to cover all TRUMPET experiments. We will not develop a separate containment plan for each experiment. Before each experiment we will present a statement to the CRP that each TRUMPET experiment falls within the parameters presented in this document. If an experiment falls outside the parameters in this document, a containment plan for that experiment will be developed and presented to the CRP for a full containment review.« less

In-service Inspection Ultrasonic Testing of Reactor Pressure Vessel Welds for Assessing Flaw Density and Size Distribution per 10 CFR 50.61a, Alternate Fracture Toughness Requirements

DOE Office of Scientific and Technical Information (OSTI.GOV)

Sullivan, Edmund J.; Anderson, Michael T.; Norris, Wallace

2012-09-17

Pressurized thermal shock (PTS) events are system transients in a pressurized water reactor (PWR) in which there is a rapid operating temperature cool-down that results in cold vessel temperatures with or without repressurization of the vessel. The rapid cooling of the inside surface of the reactor pressure vessel (RPV) causes thermal stresses that can combine with stresses caused by high pressure. The aggregate effect of these stresses is an increase in the potential for fracture if a pre-existing flaw is present in a material susceptible to brittle failure. The ferritic, low alloy steel of the reactor vessel beltline adjacent tomore » the core, where neutron radiation gradually embrittles the material over the lifetime of the plant, can be susceptible to brittle fracture. The PTS rule, described in the Code of Federal Regulations, Title 10, Section 50.61 (§50.61), “Fracture Toughness Requirements for Protection against Pressurized Thermal Shock Events,” adopted on July 23, 1985, establishes screening criteria to ensure that the potential for a reactor vessel to fail due to a PTS event is deemed to be acceptably low. The U.S. Nuclear Regulatory Commission (NRC) completed a research program that concluded that the risk of through-wall cracking due to a PTS event is much lower than previously estimated. The NRC subsequently developed a rule, §50.61a, published on January 4, 2010, entitled “Alternate Fracture Toughness Requirements for Protection Against Pressurized Thermal Shock Events” (75 FR 13). Use of the new rule by licensees is optional. The §50.61a rule differs from §50.61 in that it requires licensees who choose to follow this alternate method to analyze the results from periodic volumetric examinations required by the ASME Code, Section XI, Rules for Inservice Inspection (ISI) of Nuclear Power Plants. These analyses are intended to determine if the actual flaw density and size distribution in the licensee’s reactor vessel beltline welds are bounded by the flaw density and size distribution values used in the PTS technical basis. Under a contract with the NRC, Pacific Northwest National Laboratory (PNNL) has been working on a program to assess the ability of current inservice inspection (ISI)-ultrasonic testing (UT) techniques, as qualified through ASME Code, Appendix VIII, Supplements 4 and 6, to detect small fabrication or inservice-induced flaws located in RPV welds and adjacent base materials. As part of this effort, the investigators have pursued an evaluation, based on the available information, of the capability of UT to provide flaw density/distribution inputs for making RPV weld assessments in accordance with §50.61a. This paper presents the results of an evaluation of data from the 1993 Browns Ferry Nuclear Plant, Unit 3, Spirit of Appendix VIII reactor vessel examination, a comparison of the flaw density/distribution from this data with the distribution in §50.61a, possible reasons for differences, and plans and recommendations for further work in this area.« less

FAVOR: A new fracture mechanics code for reactor pressure vessels subjected to pressurized thermal shock

DOE Office of Scientific and Technical Information (OSTI.GOV)

Dickson, T.L.

1993-01-01

This report discusses probabilistic fracture mechanics (PFM) analysis which is a major element of the comprehensive probabilistic methodology endorsed by the NRC for evaluation of the integrity of Pressurized Water Reactor (PWR) pressure vessels subjected to pressurized-thermal-shock (PTS) transients. It is anticipated that there will be an increasing need for an improved and validated PTS PFM code which is accepted by the NRC and utilities, as more plants approach the PTS screening criteria and are required to perform plant-specific analyses. The NRC funded Heavy Section Steel Technology (HSST) Program at Oak Ridge National Laboratories is currently developing the FAVOR (Fracturemore » Analysis of Vessels: Oak Ridge) PTS PFM code, which is intended to meet this need. The FAVOR code incorporates the most important features of both OCA-P and VISA-II and contains some new capabilities such as PFM global modeling methodology, the capability to approximate the effects of thermal streaming on circumferential flaws located inside a plume region created by fluid and thermal stratification, a library of stress intensity factor influence coefficients, generated by the NQA-1 certified ABAQUS computer code, for an adequate range of two and three dimensional inside surface flaws, the flexibility to generate a variety of output reports, and user friendliness.« less

FAVOR: A new fracture mechanics code for reactor pressure vessels subjected to pressurized thermal shock

DOE Office of Scientific and Technical Information (OSTI.GOV)

Dickson, T.L.

1993-04-01

This report discusses probabilistic fracture mechanics (PFM) analysis which is a major element of the comprehensive probabilistic methodology endorsed by the NRC for evaluation of the integrity of Pressurized Water Reactor (PWR) pressure vessels subjected to pressurized-thermal-shock (PTS) transients. It is anticipated that there will be an increasing need for an improved and validated PTS PFM code which is accepted by the NRC and utilities, as more plants approach the PTS screening criteria and are required to perform plant-specific analyses. The NRC funded Heavy Section Steel Technology (HSST) Program at Oak Ridge National Laboratories is currently developing the FAVOR (Fracturemore » Analysis of Vessels: Oak Ridge) PTS PFM code, which is intended to meet this need. The FAVOR code incorporates the most important features of both OCA-P and VISA-II and contains some new capabilities such as PFM global modeling methodology, the capability to approximate the effects of thermal streaming on circumferential flaws located inside a plume region created by fluid and thermal stratification, a library of stress intensity factor influence coefficients, generated by the NQA-1 certified ABAQUS computer code, for an adequate range of two and three dimensional inside surface flaws, the flexibility to generate a variety of output reports, and user friendliness.« less

A novel mechanism of angiotensin II-regulated placental vascular tone in the development of hypertension in preeclampsia.

PubMed

Gao, Qinqin; Tang, Jiaqi; Li, Na; Zhou, Xiuwen; Li, Yongmei; Liu, Yanping; Wu, Jue; Yang, Yuxian; Shi, Ruixiu; He, Axin; Li, Xiang; Zhang, Yingying; Chen, Jie; Zhang, Lubo; Sun, Miao; Xu, Zhice

2017-05-09

The present study tested the hypothesis that angiotensin II plays a role in the regulation of placental vascular tone, which contributes to hypertension in preeclampsia. Functional and molecular assays were performed in large and micro placental and non-placental vessels from humans and animals. In human placental vessels, angiotensin II induced vasoconstrictions in 78.7% vessels in 155 tests, as referenced to KCl-induced contractions. In contrast, phenylephrine only produced contractions in 3.0% of 133 tests. In non-placental vessels, phenylephrine induced contractions in 76.0% of 67 tests, whereas angiotensin II failed to produce contractions in 75 tests. Similar results were obtained in animal placental and non-placental vessels. Compared with non-placental vessels, angiotensin II receptors and β-adrenoceptors were significantly increased in placental vessels. Compared to the vessels from normal pregnancy, angiotensin II-induced vasoconstrictions were significantly reduced in preeclamptic placentas, which was associated with a decrease in angiotensin II receptors. In addition, angiotensin II and angiotensin converting enzyme in the maternal-placenta circulation in preeclampsia were increased, whereas angiotensin I and angiotensin1-7 concentrations were unchanged. The study demonstrates a selective effect of angiotensin II in maintaining placental vessel tension, which may play an important role in development of hypertension in preeclampsia.

LH2 Tank Composite Coverplate Development and Flight Qualification for the X-33

NASA Technical Reports Server (NTRS)

Wright, Richard J.; Roule, Gerard M.

2000-01-01

In this paper, the development history for the first cryogenic pressurized fuel tank coverplates is presented along with a synopsis of the development strategy and technologies which led to success on this program. Coverplates are the large access panels used to access launch vehicle fuel tanks. These structures incorporate all of the requirements for a pressure vessel as well as the added requirement to mount all of the miscellaneous access points required for a fuel management system. The first composite coverplates to meet the requirements for flight qualification were developed on the X-33 program. The X-33 composite coverplates went from an open requirement to successful finished flight hardware with multiple unique configurations, complete with verification testing, in less than eighteen months. Besides the rapid development schedule, these components introduced several new technologies previously unseen in cryogenic composites including solutions to cryogenic shrinkage, self-supporting sealing surfaces, and highly loaded composite bosses with precision sealing interfaces. These components were proven to seal liquid hydrogen at cryogenic temperatures under maximum loading and pressure conditions.

Bisphenol A affects placental layers morphology and angiogenesis during early pregnancy phase in mice.

PubMed

Tait, Sabrina; Tassinari, Roberta; Maranghi, Francesca; Mantovani, Alberto

2015-11-01

Bisphenol A (BPA) is a widespread endocrine disrupter mainly used in food contact plastics. Much evidence supports the adverse effects of BPA, particularly on susceptible groups such as pregnant women. The present study considered placental development - relevant for pregnancy outcomes and fetal nutrition/programming - as a potential target of BPA. Pregnant CD-1 mice were administered per os with vehicle, 0.5 (BPA05) or 50 mg kg(-1) (BPA50) body weight day(-1) of BPA, from gestational day (GD) 1 to GD11. At GD12, BPA50 induced significant degeneration and necrosis of giant cells, increased vacuolization in the junctional zone in the absence of glycogen accumulation and reduction of the spongiotrophoblast layer. In addition, BPA05 induced glycogen depletion as well as significant nuclear accumulation of β-catenin in trophoblasts of labyrinthine and spongiotrophoblast layers, supporting the activation of the Wnt/β-catenin pathway. Transcriptomic analysis indicated that BPA05 promoted and BPA50 inhibited blood vessel development and branching; morphologically, maternal vessels were narrower in BPA05 placentas, whereas embryonic and maternal vessels were irregularly dilated in the labyrinth of BPA50 placentas. Quantitative polymerase chain reaction evidenced an estrogen receptor β induction by BPA50, which did not correspond to downstream genes activation; indeed, the transcription factor binding sites analysis supported the AhR/Arnt complex as regulator of BPA50-modulated genes. Conversely, Creb appeared as the main transcription factor regulating BPA05-modulated genes. Embryonic structures (head, forelimb) showed divergent perturbations upon BPA05 or BPA50 exposure, potentially related to unbalanced embryonic nutrition and/or to modulation of genes involved in embryo development. Our findings support placenta as an important target of BPA, even at environmentally relevant dose levels. Copyright © 2015 John Wiley & Sons, Ltd.

Deposition of collagen type I onto skeletal endothelium reveals a new role for blood vessels in regulating bone morphology

PubMed Central

Ben Shoham, Adi; Rot, Chagai; Stern, Tomer; Krief, Sharon; Akiva, Anat; Dadosh, Tali; Sabany, Helena; Lu, Yinhui; Kadler, Karl E.

2016-01-01

Recently, blood vessels have been implicated in the morphogenesis of various organs. The vasculature is also known to be essential for endochondral bone development, yet the underlying mechanism has remained elusive. We show that a unique composition of blood vessels facilitates the role of the endothelium in bone mineralization and morphogenesis. Immunostaining and electron microscopy showed that the endothelium in developing bones lacks basement membrane, which normally isolates the blood vessel from its surroundings. Further analysis revealed the presence of collagen type I on the endothelial wall of these vessels. Because collagen type I is the main component of the osteoid, we hypothesized that the bone vasculature guides the formation of the collagenous template and consequently of the mature bone. Indeed, some of the bone vessels were found to undergo mineralization. Moreover, the vascular pattern at each embryonic stage prefigured the mineral distribution pattern observed one day later. Finally, perturbation of vascular patterning by overexpressing Vegf in osteoblasts resulted in abnormal bone morphology, supporting a role for blood vessels in bone morphogenesis. These data reveal the unique composition of the endothelium in developing bones and indicate that vascular patterning plays a role in determining bone shape by forming a template for deposition of bone matrix. PMID:27621060

Status of nickel-hydrogen cell technology

NASA Technical Reports Server (NTRS)

Warnock, D. R.

1980-01-01

Nickel hydrogen cell technology has been developed which solves the problems of thermal management, oxygen management, electrolyte management, and electrical and mechanical design peculiar to this new type of battery. This technology was weight optimized for low orbit operation using computer modeling programs but is near optimum for other orbits. Cells ranging in capacity up to about 70 ampere-hours can be made from components of a single standard size and are available from two manufacturers. The knowledge gained is now being applied to the development of two extensions to the basic design: a second set of larger standard components that will cover the capacity range up to 150 ampere-hours; and the development of multicell common pressure vessel modules to reduce volume, cost and weight. A manufacturing technology program is planned to optimize the producibility of the cell design and reduce cost. The most important areas for further improvement are life and reliability which are governed by electrode and separator technology.

Robust approach to ocular fundus image analysis

NASA Astrophysics Data System (ADS)

Tascini, Guido; Passerini, Giorgio; Puliti, Paolo; Zingaretti, Primo

1993-07-01

The analysis of morphological and structural modifications of retinal blood vessels plays an important role both to establish the presence of some systemic diseases as hypertension and diabetes and to study their course. The paper describes a robust set of techniques developed to quantitatively evaluate morphometric aspects of the ocular fundus vascular and micro vascular network. They are defined: (1) the concept of 'Local Direction of a vessel' (LD); (2) a special form of edge detection, named Signed Edge Detection (SED), which uses LD to choose the convolution kernel in the edge detection process and is able to distinguish between the left or the right vessel edge; (3) an iterative tracking (IT) method. The developed techniques use intensively both LD and SED in: (a) the automatic detection of number, position and size of blood vessels departing from the optical papilla; (b) the tracking of body and edges of the vessels; (c) the recognition of vessel branches and crossings; (d) the extraction of a set of features as blood vessel length and average diameter, arteries and arterioles tortuosity, crossing position and angle between two vessels. The algorithms, implemented in C language, have an execution time depending on the complexity of the currently processed vascular network.

Automatic multiscale enhancement and segmentation of pulmonary vessels in CT pulmonary angiography images for CAD applications

DOE Office of Scientific and Technical Information (OSTI.GOV)

Zhou Chuan; Chan, H.-P.; Sahiner, Berkman

2007-12-15

The authors are developing a computerized pulmonary vessel segmentation method for a computer-aided pulmonary embolism (PE) detection system on computed tomographic pulmonary angiography (CTPA) images. Because PE only occurs inside pulmonary arteries, an automatic and accurate segmentation of the pulmonary vessels in 3D CTPA images is an essential step for the PE CAD system. To segment the pulmonary vessels within the lung, the lung regions are first extracted using expectation-maximization (EM) analysis and morphological operations. The authors developed a 3D multiscale filtering technique to enhance the pulmonary vascular structures based on the analysis of eigenvalues of the Hessian matrix atmore » multiple scales. A new response function of the filter was designed to enhance all vascular structures including the vessel bifurcations and suppress nonvessel structures such as the lymphoid tissues surrounding the vessels. An EM estimation is then used to segment the vascular structures by extracting the high response voxels at each scale. The vessel tree is finally reconstructed by integrating the segmented vessels at all scales based on a 'connected component' analysis. Two CTPA cases containing PEs were used to evaluate the performance of the system. One of these two cases also contained pleural effusion disease. Two experienced thoracic radiologists provided the gold standard of pulmonary vessels including both arteries and veins by manually tracking the arterial tree and marking the center of the vessels using a computer graphical user interface. The accuracy of vessel tree segmentation was evaluated by the percentage of the 'gold standard' vessel center points overlapping with the segmented vessels. The results show that 96.2% (2398/2494) and 96.3% (1910/1984) of the manually marked center points in the arteries overlapped with segmented vessels for the case without and with other lung diseases. For the manually marked center points in all vessels including arteries and veins, the segmentation accuracy are 97.0% (4546/4689) and 93.8% (4439/4732) for the cases without and with other lung diseases, respectively. Because of the lack of ground truth for the vessels, in addition to quantitative evaluation of the vessel segmentation performance, visual inspection was conducted to evaluate the segmentation. The results demonstrate that vessel segmentation using our method can extract the pulmonary vessels accurately and is not degraded by PE occlusion to the vessels in these test cases.« less

Water Quality Research Program: Recent Developments in the Analysis of Metals in Water, Wastewater, and Other Matrices.

DTIC Science & Technology

1987-11-01

for various types of samples and acids. The system features PFA -closed vessels that will tolerate up to 100 psi, a Teflon-lined cavity that reduces...complexes. Selec- tivity is accomplished by masking agents and pH adjustment and sorption on a small XAD-4 resin column. Evaporation of solvent 119...same pH, Cr(VI) is selectively reduced to Cr(III) and accumulated by adsorption at -0.3 V versus SCE (Batley and Matousek 1980). 150. Sorption , ion

Energy use in the marine transportation industry. Task II. Efficiency improvements. Draft report

DOE Office of Scientific and Technical Information (OSTI.GOV)

Not Available

1977-06-02

Research and development areas that hold promise for maritime energy conservation are identified and evaluated. The methodology used in the evaluation of potential research areas and results, conclusions, and recommendations are presented. Fifteen programs are identified in four generic technologies and these are discussed in detail in appendices A-D. The areas are: main propulsion plants, propulsors, hydrodynamics, and vessel operations. Fuels are discussed briefly in appendix E. Additional information is presented on the generic US flag baseline operational and cost parameters; a sample output model is presented. (MCW)

40 CFR 1045.405 - How does this program work?

Code of Federal Regulations, 2010 CFR

2010-07-01

... 40 Protection of Environment 32 2010-07-01 2010-07-01 false How does this program work? 1045.405 Section 1045.405 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR POLLUTION CONTROLS CONTROL OF EMISSIONS FROM SPARK-IGNITION PROPULSION MARINE ENGINES AND VESSELS In-Use Testing...

40 CFR 1045.405 - How does this program work?

Code of Federal Regulations, 2014 CFR

2014-07-01

... 40 Protection of Environment 33 2014-07-01 2014-07-01 false How does this program work? 1045.405 Section 1045.405 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR POLLUTION CONTROLS CONTROL OF EMISSIONS FROM SPARK-IGNITION PROPULSION MARINE ENGINES AND VESSELS In-Use Testing...

40 CFR 1045.405 - How does this program work?

Code of Federal Regulations, 2013 CFR

2013-07-01

... 40 Protection of Environment 34 2013-07-01 2013-07-01 false How does this program work? 1045.405 Section 1045.405 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR POLLUTION CONTROLS CONTROL OF EMISSIONS FROM SPARK-IGNITION PROPULSION MARINE ENGINES AND VESSELS In-Use Testing...

40 CFR 1045.405 - How does this program work?

Code of Federal Regulations, 2012 CFR

2012-07-01

... 40 Protection of Environment 34 2012-07-01 2012-07-01 false How does this program work? 1045.405 Section 1045.405 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR POLLUTION CONTROLS CONTROL OF EMISSIONS FROM SPARK-IGNITION PROPULSION MARINE ENGINES AND VESSELS In-Use Testing...

40 CFR 1045.405 - How does this program work?

Code of Federal Regulations, 2011 CFR

2011-07-01

... 40 Protection of Environment 33 2011-07-01 2011-07-01 false How does this program work? 1045.405 Section 1045.405 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR POLLUTION CONTROLS CONTROL OF EMISSIONS FROM SPARK-IGNITION PROPULSION MARINE ENGINES AND VESSELS In-Use Testing...

75 FR 62326 - Magnuson-Stevens Act Provisions; Fishing Capacity Reduction Framework

Federal Register 2010, 2011, 2012, 2013, 2014

2010-10-08

.... 100330171-0388-02] RIN 0648-AY79 Magnuson-Stevens Act Provisions; Fishing Capacity Reduction Framework... implementing fishing capacity reduction programs (reduction programs) in accordance with the Magnuson-Stevens... pays harvesters in a fishery that has more vessels than capacity either to surrender their fishing...

Blood Vessel Tension Tester

NASA Technical Reports Server (NTRS)

1978-01-01

In the photo, a medical researcher is using a specially designed laboratory apparatus for measuring blood vessel tension. It was designed by Langley Research Center as a service to researchers of Norfolk General Hospital and Eastern Virginia Medical School, Norfolk, Virginia. The investigators are studying how vascular smooth muscle-muscle in the walls of blood vessels-reacts to various stimulants, such as coffee, tea, alcohol or drugs. They sought help from Langley Research Center in devising a method of measuring the tension in blood vessel segments subjected to various stimuli. The task was complicated by the extremely small size of the specimens to be tested, blood vessel "loops" resembling small rubber bands, some only half a millimeter in diameter. Langley's Instrumentation Development Section responded with a miniaturized system whose key components are a "micropositioner" for stretching a length of blood vessel and a strain gage for measuring the smooth muscle tension developed. The micropositioner is a two-pronged holder. The loop of Mood vessel is hooked over the prongs and it is stretched by increasing the distance between the prongs in minute increments, fractions of a millimeter. At each increase, the tension developed is carefully measured. In some experiments, the holder and specimen are lowered into the test tubes shown, which contain a saline solution simulating body fluid; the effect of the compound on developed tension is then measured. The device has functioned well and the investigators say it has saved several months research time.

Characterization of an Isolated Kidney's Vasculature for Use in Bio-Thermal Modeling

NASA Astrophysics Data System (ADS)

Payne, Allison H.; Parker, Dennis L.; Moellmer, Jeff; Roemer, Robert B.; Clifford, Sarah

2007-05-01

Accurate bio-thermal modeling requires site-specific modeling of discrete vascular anatomy. Presented herewith are several steps that have been developed to describe the vessel network of isolated canine and bovine kidneys. These perfused, isolated kidneys provide an environment to repeatedly test and improve acquisition methods to visualize the vascular anatomy, as well as providing a method to experimentally validate discrete vasculature thermal models. The organs are preserved using a previously developed methodology that keeps the vasculature intact, allowing for the organ to be perfused. It also allows for the repeated fixation and re-hydration of the same organ, permitting the comparison of various methods and models. The organ extraction, alcohol preservation, and perfusion of the organ are described. The vessel locations were obtained through a high-resolution time-of-flight (TOF) magnetic resonance angiography (MRA) technique. Sequential improvements of both the experimental setup used for this acquisition, as well as MR sequence development are presented. The improvements in MR acquisition and experimental setup improved the number of vessels seen in both the raw data and segmented images by 50%. An automatic vessel centerline extraction algorithm describes both vessel location and genealogy. Centerline descriptions also allows for vessel diameter and flow rate determination, providing valuable input parameters for the discrete vascular thermal model. Characterized vessels networks of both canine and bovine kidneys are presented. While these tools have been developed in an ex vivo environment, all steps can be applied to in vivo applications.

Superconducting magnetic energy storage apparatus structural support system

DOEpatents

Withers, Gregory J.; Meier, Stephen W.; Walter, Robert J.; Child, Michael D.; DeGraaf, Douglas W.

1992-01-01

A superconducting magnetic energy storage apparatus comprising a cylindrical superconducting coil; a cylindrical coil containment vessel enclosing the coil and adapted to hold a liquid, such as liquefied helium; and a cylindrical vacuum vessel enclosing the coil containment vessel and located in a restraining structure having inner and outer circumferential walls and a floor; the apparatus being provided with horizontal compression members between (1) the coil and the coil containment vessel and (2) between the coil containment vessel and the vacuum vessel, compression bearing members between the vacuum vessel and the restraining structure inner and outer walls, vertical support members (1) between the coil bottom and the coil containment vessel bottom and (2) between the coil containment vessel bottom and the vacuum vessel bottom, and external supports between the vacuum vessel bottom and the restraining structure floor, whereby the loads developed by thermal and magnetic energy changes in the apparatus can be accommodated and the structural integrity of the apparatus be maintained.

Development of glia and blood vessels in the internal capsule of rats.

PubMed

Earle, K L; Mitrofanis, J

1998-02-01

We have explored two aspects of internal capsule development that have not been described previously, namely, the development of glia and of blood vessels. To these ends, we used antibodies to glial fibrillary acidic protein (GFAP) and to vimentin (to identify astrocytes and to radial glia) and Griffonia simplicifolia (lectin; to identify microglia and blood vessels). Further, we made intracardiac injections of Evans Blue to examine the permeability of this dye in the vessels of the internal capsule during neonatal development. Our results show that large numbers of radial glia, astrocytes and microglia are not labelled with these markers in the white matter of the internal capsule until about birth; very few are labelled earlier, during the critical stages of corticofugal and corticopetal axonal ingrowth (E15-E20). The large glial labelling in the internal capsule at birth is accompanied by a dense vascular innervation of the capsule; as with the glia, very few labelled patent vessels are seen earlier. After intracardiac injections of Evans Blue, we find that the blood vessels of the internal capsule are not particularly permeable to Evans Blue. At each age examined (P0, P5, P15), blood vessels are outlined very clearly and there is no diffuse haze of fluorescence within the extracellular space, which is indicative of a leaky vessel. There are three striking differences between the glial environment of the internal capsule and that of the adjacent thalamus. First, the internal capsule is never rich with radial glial fibres (vimentin- and GFAP-immunoreactive) during development (except at P0), whereas the thalamus has many radial fibres from very early development (E15-E17). Second, astrocytes (vimentin- and GFAP-immunoreactive) first become apparent in the internal capsule (E20-P0) well before they do in the thalamus (P15). Third, the internal capsule houses a large transient population of amoeboid microglia (P0-P22), whereas the thalamus does not; only ramified microglia are seen in the thalamus. In summary, our results indicate that all three types of glia in the internal capsule are associated closely with the vasculature, suggesting they may play a role in the development of the blood-brain barrier among the vessels in this white matter region of the forebrain.

Time-dependent response of filamentary composite spherical pressure vessels

NASA Technical Reports Server (NTRS)

Dozier, J. D.

1983-01-01

A filamentary composite spherical pressure vessel is modeled as a pseudoisotropic (or transversely isotropic) composite shell, with the effects of the liner and fill tubes omitted. Equations of elasticity, macromechanical and micromechanical formulations, and laminate properties are derived for the application of an internally pressured spherical composite vessel. Viscoelastic properties for the composite matrix are used to characterize time-dependent behavior. Using the maximum strain theory of failure, burst pressure and critical strain equations are formulated, solved in the Laplace domain with an associated elastic solution, and inverted back into the time domain using the method of collocation. Viscoelastic properties of HBFR-55 resin are experimentally determined and a Kevlar/HBFR-55 system is evaluated with a FORTRAN program. The computed reduction in burst pressure with respect to time indicates that the analysis employed may be used to predict the time-dependent response of a filamentary composite spherical pressure vessel.

Detecting terrorist nuclear weapons at sea: The 10th door problem

DOE Office of Scientific and Technical Information (OSTI.GOV)

Slaughter, D R

2008-09-15

While screening commercial cargo containers for the possible presence of WMD is important and necessary smugglers have successfully exploited the many other vehicles transporting cargo into the US including medium and small vessels at sea. These vessels provide a venue that is currently not screened and widely used. Physics limits that make screening of large vessels prohibitive impractical do not prohibit effective screening of the smaller vessels. While passive radiation detection is probably ineffective at sea active interrogation may provide a successful approach. The physics limits of active interrogation of ships at sea from standoff platforms are discussed. Autonomous platformsmore » that could carry interrogation systems at sea, both airborne and submersible, are summarized and their utilization discussed. An R&D program to investigate the limits of this approach to screening ships at sea is indicated and limitations estimated.« less

Acoustic emission testing of composite vessels under sustained loading

NASA Technical Reports Server (NTRS)

Lark, R. F.; Moorhead, P. E.

1978-01-01

Acoustic emission (AE) tests have been conducted on small-diameter Kevlar 49/epoxy pressure vessels subjected to long-term sustained load-to-failure tests. Single-cycle burst tests were used as a basis for determining the test pressure in the sustained-loading tests. AE data from two vessel locations were compared. The data suggest that AE from vessel wall-mounted transducers is quite different for identical vessels subjected to the same pressure loading. AE from boss-mounted transducers yielded relatively consistent values. These values were not a function of time for vessel failure. The development of an AE test procedure for predicting the residual service life or integrity of composite vessels is discussed.

Development of advanced manufacturing technologies for low cost hydrogen storage vessels

DOE Office of Scientific and Technical Information (OSTI.GOV)

Leavitt, Mark; Lam, Patrick

2014-12-29

The U.S. Department of Energy (DOE) defined a need for low-cost gaseous hydrogen storage vessels at 700 bar to support cost goals aimed at 500,000 units per year. Existing filament winding processes produce a pressure vessel that is structurally inefficient, requiring more carbon fiber for manufacturing reasons, than would otherwise be necessary. Carbon fiber is the greatest cost driver in building a hydrogen pressure vessel. The objective of this project is to develop new methods for manufacturing Type IV pressure vessels for hydrogen storage with the purpose of lowering the overall product cost through an innovative hybrid process of optimizingmore » composite usage by combining traditional filament winding (FW) and advanced fiber placement (AFP) techniques. A numbers of vessels were manufactured in this project. The latest vessel design passed all the critical tests on the hybrid design per European Commission (EC) 79-2009 standard except the extreme temperature cycle test. The tests passed include burst test, cycle test, accelerated stress rupture test and drop test. It was discovered the location where AFP and FW overlap for load transfer could be weakened during hydraulic cycling at 85°C. To design a vessel that passed these tests, the in-house modeling software was updated to add capability to start and stop fiber layers to simulate the AFP process. The original in-house software was developed for filament winding only. Alternative fiber was also investigated in this project, but the added mass impacted the vessel cost negatively due to the lower performance from the alternative fiber. Overall the project was a success to show the hybrid design is a viable solution to reduce fiber usage, thus driving down the cost of fuel storage vessels. Based on DOE’s baseline vessel size of 147.3L and 91kg, the 129L vessel (scaled to DOE baseline) in this project shows a 32% composite savings and 20% cost savings when comparing Vessel 15 hybrid design and the Quantum baseline all filament wound vessel. Due to project timing, there was no additional time available to fine tune the design to improve the load transfer between AFP and FW. Further design modifications will likely help pass the extreme temperature cycle test, the remaining test that is critical to the hybrid design.« less

Lessons From the Pioneer Venus Program

NASA Technical Reports Server (NTRS)

Dorfman, Steven D.

2005-01-01

We began the Pioneer Venus contract in late 1974 with a planned launch of the Orbiter in May 1978 and the Multiprobe in August 1978. Because we had four years, we thought there was plenty of time. As it turned out, we barely made the launch dates. The Orbiter was relatively straightforward, compared to the Multiprobe Bus and Probes that had to survive descent through the harsh Venusian atmosphere. To help overcome our many Multiprobe problems we formed a strong global team. The GE reentry team in Philadelphia, experienced in designing vehicles to enter the earth s atmosphere, was assigned the responsibility for the Probe entry system, including protective heat shielding and parachute design to extract the scienceladen Large Probe pressure vessel and control its descent through the Venusian clouds. Since the Probes had to remain stable as they descended through the Venus atmosphere, we used the aerodynamic expertise at the Hughes Missile Division, NASA s Ames Research Center and the Langley Research Center. Since the pressure at the surface of Venus was equivalent to an ocean depth of 3300 feet, we went to the Navy s David Taylor Research Center for their deepsea expertise. To test the pressure vessel at the high pressure and temperatures anticipated at Venus we went to the only facility capable of simulating the Venus surface environment, the Southwest Research Institute in San Antonio, Texas. We had dozens of subcontractors all over the world. As we developed our design, we began an extensive program to validate the ability of our Probe hardware to withstand the Venus environment. During this testing, we encountered numerous problems, mostly associated with adapting earth-based hardware to operate in the anticipated Venus environment. For example, the Large Probe pressure vessel imploded with a very loud bang the first time we tested its ability to withstand the high pressure and temperature on the Venusian surface. We had to go back and redesign, increasing the pressure vessel wall thickness. In addition, during the first tests of the parachute system, our parachute system ripped apart and had to be redesigned. Finally, at the aptly named test range in Truth or Consequences, New Mexico, we successfully demonstrated the parachute design by drop

Vital microscopic analysis of polymeric micelle extravasation from tumor vessels: macromolecular delivery according to tumor vascular growth stage.

PubMed

Hori, Katsuyoshi; Nishihara, Masamichi; Yokoyama, Masayuki

2010-01-01

Particles larger than a specific size have been thought to extravasate from tumor vessels but not from normal vessels. Therefore, various nanoparticles incorporating anticancer drugs have been developed to realize selective drug delivery to solid tumors. However, it is not yet clear whether nanoparticles extravasate readily from all tumor vessels including vessels of microtumors. To answer this question, we synthesized new polymeric micelles labeled with fluorescein isothiocyanate (FITC) and injected them into the tail vein of rats with implanted skinfold transparent chambers. We also analyzed, by means of time-lapse vital microscopy with image analysis, extravasation of FITC micelles from tumor vessels at different stages of growth of Yoshida ascites sarcoma LY80. Polymeric micelles readily leaked from vessels at the interface between normal and tumor tissues and those at the interface between tumor tissues and necrotic areas. The micelles showed negligible extravasation, however, from the vascular network of microtumors less than 1 mm in diameter and did not accumulate in the microtumor. Our results suggest that we must develop a novel therapeutic strategy that can deliver sufficient nanomedicine to microtumors.

Energy use in the marine transportation industry. Task III. Efficiency improvements. Draft report

DOE Office of Scientific and Technical Information (OSTI.GOV)

Not Available

1977-06-02

Research and development areas that hold promise for maritime energy conservation are identified and evaluated. The methodology used is discussed in Chapter II. The technology base of the commercial marine transportation industry relating to energy usage is made up of: main propulsion plants, propulsors, hydrodynamics, vessel operations, and fuels. Fifteen specific program areas in the first four generic technologies are identified and are evaluated. An economic and energy impact analysis and technological risk assessment was performed on the specific program areas and the results are summarized in Chapter III. The first five appendices address the generic technologies. The sixth appendixmore » contains the baseline operating and cost parameters against which the 15 program areas were evaluated, and the last appendix contains sample printouts of the MTEM model used to evaluate the energy consumption and economic impacts associated with the candidate technology areas. (MCW)« less

Structural Optimization for Reliability Using Nonlinear Goal Programming

NASA Technical Reports Server (NTRS)

El-Sayed, Mohamed E.

1999-01-01

This report details the development of a reliability based multi-objective design tool for solving structural optimization problems. Based on two different optimization techniques, namely sequential unconstrained minimization and nonlinear goal programming, the developed design method has the capability to take into account the effects of variability on the proposed design through a user specified reliability design criterion. In its sequential unconstrained minimization mode, the developed design tool uses a composite objective function, in conjunction with weight ordered design objectives, in order to take into account conflicting and multiple design criteria. Multiple design criteria of interest including structural weight, load induced stress and deflection, and mechanical reliability. The nonlinear goal programming mode, on the other hand, provides for a design method that eliminates the difficulty of having to define an objective function and constraints, while at the same time has the capability of handling rank ordered design objectives or goals. For simulation purposes the design of a pressure vessel cover plate was undertaken as a test bed for the newly developed design tool. The formulation of this structural optimization problem into sequential unconstrained minimization and goal programming form is presented. The resulting optimization problem was solved using: (i) the linear extended interior penalty function method algorithm; and (ii) Powell's conjugate directions method. Both single and multi-objective numerical test cases are included demonstrating the design tool's capabilities as it applies to this design problem.

Stochastic simulation of human pulmonary blood flow and transit time frequency distribution based on anatomic and elasticity data.

PubMed

Huang, Wei; Shi, Jun; Yen, R T

2012-12-01

The objective of our study was to develop a computing program for computing the transit time frequency distributions of red blood cell in human pulmonary circulation, based on our anatomic and elasticity data of blood vessels in human lung. A stochastic simulation model was introduced to simulate blood flow in human pulmonary circulation. In the stochastic simulation model, the connectivity data of pulmonary blood vessels in human lung was converted into a probability matrix. Based on this model, the transit time of red blood cell in human pulmonary circulation and the output blood pressure were studied. Additionally, the stochastic simulation model can be used to predict the changes of blood flow in human pulmonary circulation with the advantage of the lower computing cost and the higher flexibility. In conclusion, a stochastic simulation approach was introduced to simulate the blood flow in the hierarchical structure of a pulmonary circulation system, and to calculate the transit time distributions and the blood pressure outputs.

Targeting Therapy Resistant Tumor Vessels

DTIC Science & Technology

2007-05-01

Porkka K, Laakko- nen P, Ruoslahti E. Nucleolin expressed at the cell surface is a marker of endothelial cells in angiogenic blood vessels. J Cell...anti-angiogenic therapy. Markers of such vessels will be useful in developing strategies for complete destruction of breast cancer vasculature, and in...express specific markers , and that these lymphatic markers are tumor type specific and distinct from blood vessel markers in the same tumors. The

Is There a Space-Based Technology Solution to Problems with Preclinical Drug Toxicity Testing?

PubMed

Hammond, Timothy; Allen, Patricia; Birdsall, Holly

2016-07-01

Even the finest state-of-the art preclinical drug testing, usually in primary hepatocytes, remains an imperfect science. Drugs continue to be withdrawn from the market due to unforeseen toxicity, side effects, and drug interactions. The space program may be able to provide a lifeline. Best known for rockets, space shuttles, astronauts and engineering, the space program has also delivered some serious medical science. Optimized suspension culture in NASA's specialized suspension culture devices, known as rotating wall vessels, uniquely maintains Phase I and Phase II drug metabolizing pathways in hepatocytes for weeks in cell culture. Previously prohibitively expensive, new materials and 3D printing techniques have the potential to make the NASA rotating wall vessel available inexpensively on an industrial scale. Here we address the tradeoffs inherent in the rotating wall vessel, limitations of alternative approaches for drug metabolism studies, and the market to be addressed. Better pre-clinical drug testing has the potential to significantly reduce the morbidity and mortality of one of the most common problems in modern medicine: adverse events related to pharmaceuticals.

Reducing catheter-related thrombosis using a risk reduction tool centered on catheter to vessel ratio.

PubMed

Spencer, Timothy R; Mahoney, Keegan J

2017-11-01

In vascular access practices, the internal vessel size is considered important, and a catheter to vessel ratio (CVR) is recommended to assist clinicians in selecting the most appropriate-sized device for the vessel. In 2016, new practice recommendations stated that the CVR can increase from 33 to 45% of the vessels diameter. There has been evidence on larger diameter catheters and increased thrombosis risk in recent literature, while insufficient information established on what relationship to vessel size is appropriate for any intra-vascular device. Earlier references to clinical standards and guidelines did not clearly address vessel size in relation to the area consumed or external catheter diameter. The aim of this manuscript is to present catheter-related thrombosis evidence and develop a standardized process of ultrasound-guided vessel assessment, integrating CVR, Virchow's triad phenomenon and vessel health and preservation strategies, empowering an evidence-based approach to device placement. Through review, calculation and assessment on the areas of the 33 and 45% rule, a preliminary clinical tool was developed to assist clinicians make cognizant decisions when placing intravascular devices relating to target vessel size, focusing on potential reduction in catheter-related thrombosis. Increasing the understanding and utilization of CVRs will lead to a safer, more consistent approach to device placement, with potential thrombosis reduction strategies. The future of evidence-based data relies on the clinician to capture accurate vessel measurements and device-related outcomes. This will lead to a more dependable data pool, driving the relationship of catheter-related thrombosis and vascular assessment.

50 CFR 85.31 - Grant selection.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 50 Wildlife and Fisheries 6 2010-10-01 2010-10-01 false Grant selection. 85.31 Section 85.31...) FINANCIAL ASSISTANCE-WILDLIFE SPORT FISH RESTORATION PROGRAM CLEAN VESSEL ACT GRANT PROGRAM Grant Selection § 85.31 Grant selection. The Fish and Wildlife Service, Division of Federal Aid, will convene a ranking...

46 CFR 176.660 - Continued participation in the Alternative Hull Examination (AHE) Program.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 46 Shipping 7 2010-10-01 2010-10-01 false Continued participation in the Alternative Hull... (CONTINUED) SMALL PASSENGER VESSELS (UNDER 100 GROSS TONS) INSPECTION AND CERTIFICATION Hull and Tailshaft Examinations § 176.660 Continued participation in the Alternative Hull Examination (AHE) Program. (a) To...

46 CFR 16.230 - Random testing requirements.

Code of Federal Regulations, 2013 CFR

2013-10-01

... programs for the chemical testing for dangerous drugs on a random basis of crewmembers on inspected vessels... establish programs for the chemical testing for dangerous drugs on a random basis of crewmembers on... random drug testing shall be made by a scientifically valid method, such as a random number table or a...

46 CFR 16.230 - Random testing requirements.

Code of Federal Regulations, 2012 CFR

2012-10-01

... programs for the chemical testing for dangerous drugs on a random basis of crewmembers on inspected vessels... establish programs for the chemical testing for dangerous drugs on a random basis of crewmembers on... random drug testing shall be made by a scientifically valid method, such as a random number table or a...

46 CFR 16.230 - Random testing requirements.

Code of Federal Regulations, 2010 CFR

2010-10-01

... programs for the chemical testing for dangerous drugs on a random basis of crewmembers on inspected vessels... establish programs for the chemical testing for dangerous drugs on a random basis of crewmembers on... random drug testing shall be made by a scientifically valid method, such as a random number table or a...

46 CFR 16.230 - Random testing requirements.

Code of Federal Regulations, 2011 CFR

2011-10-01

... programs for the chemical testing for dangerous drugs on a random basis of crewmembers on inspected vessels... establish programs for the chemical testing for dangerous drugs on a random basis of crewmembers on... random drug testing shall be made by a scientifically valid method, such as a random number table or a...

46 CFR 16.230 - Random testing requirements.

Code of Federal Regulations, 2014 CFR

2014-10-01

... programs for the chemical testing for dangerous drugs on a random basis of crewmembers on inspected vessels... establish programs for the chemical testing for dangerous drugs on a random basis of crewmembers on... random drug testing shall be made by a scientifically valid method, such as a random number table or a...

Retinal imaging analysis based on vessel detection.

PubMed

Jamal, Arshad; Hazim Alkawaz, Mohammed; Rehman, Amjad; Saba, Tanzila

2017-07-01

With an increase in the advancement of digital imaging and computing power, computationally intelligent technologies are in high demand to be used in ophthalmology cure and treatment. In current research, Retina Image Analysis (RIA) is developed for optometrist at Eye Care Center in Management and Science University. This research aims to analyze the retina through vessel detection. The RIA assists in the analysis of the retinal images and specialists are served with various options like saving, processing and analyzing retinal images through its advanced interface layout. Additionally, RIA assists in the selection process of vessel segment; processing these vessels by calculating its diameter, standard deviation, length, and displaying detected vessel on the retina. The Agile Unified Process is adopted as the methodology in developing this research. To conclude, Retina Image Analysis might help the optometrist to get better understanding in analyzing the patient's retina. Finally, the Retina Image Analysis procedure is developed using MATLAB (R2011b). Promising results are attained that are comparable in the state of art. © 2017 Wiley Periodicals, Inc.

SPLASH program for three dimensional fluid dynamics with free surface boundaries

NASA Astrophysics Data System (ADS)

Yamaguchi, A.

1996-05-01

This paper describes a three dimensional computer program SPLASH that solves Navier-Stokes equations based on the Arbitrary Lagrangian Eulerian (ALE) finite element method. SPLASH has been developed for application to the fluid dynamics problems including the moving boundary of a liquid metal cooled Fast Breeder Reactor (FBR). To apply SPLASH code to the free surface behavior analysis, a capillary model using a cubic Spline function has been developed. Several sample problems, e.g., free surface oscillation, vortex shedding development, and capillary tube phenomena, are solved to verify the computer program. In the analyses, the numerical results are in good agreement with the theoretical value or experimental observance. Also SPLASH code has been applied to an analysis of a free surface sloshing experiment coupled with forced circulation flow in a rectangular tank. This is a simplified situation of the flow field in a reactor vessel of the FBR. The computational simulation well predicts the general behavior of the fluid flow inside and the free surface behavior. Analytical capability of the SPLASH code has been verified in this study and the application to more practical problems such as FBR design and safety analysis is under way.

Acoustic emission testing of composite vessels under sustained loading

NASA Technical Reports Server (NTRS)

Lark, R. F.; Moorhead, P. E.

1978-01-01

Acoustic emissions (AE) generated from Kevlar 49/epoxy composite pressure vessels subjected to sustained load-to-failure tests were studied. Data from two different transducer locations on the vessels were compared. It was found that AE from vessel wall-mounted transducers showed a wide variance from those for identical vessels subjected to the same pressure loading. Emissions from boss-mounted transducers did, however, yield values that were relatively consistent. It appears that the signals from the boss-mounted transducers represent an integrated average of the emissions generated by fibers fracturing during the vessel tests. The AE from boss-mounted transducers were also independent of time for vessel failure. This suggests that a similar number of fiber fractures must occur prior to initiation of vessel failure. These studies indicate a potential for developing an AE test procedure for predicting the residual service life or integrity of composite vessels.

Probabilistic retinal vessel segmentation

NASA Astrophysics Data System (ADS)

Wu, Chang-Hua; Agam, Gady

2007-03-01

Optic fundus assessment is widely used for diagnosing vascular and non-vascular pathology. Inspection of the retinal vasculature may reveal hypertension, diabetes, arteriosclerosis, cardiovascular disease and stroke. Due to various imaging conditions retinal images may be degraded. Consequently, the enhancement of such images and vessels in them is an important task with direct clinical applications. We propose a novel technique for vessel enhancement in retinal images that is capable of enhancing vessel junctions in addition to linear vessel segments. This is an extension of vessel filters we have previously developed for vessel enhancement in thoracic CT scans. The proposed approach is based on probabilistic models which can discern vessels and junctions. Evaluation shows the proposed filter is better than several known techniques and is comparable to the state of the art when evaluated on a standard dataset. A ridge-based vessel tracking process is applied on the enhanced image to demonstrate the effectiveness of the enhancement filter.

Arctic research vessel design would expand science prospects

NASA Astrophysics Data System (ADS)

Elsner, Robert; Kristensen, Dirk

The U.S. polar marine science community has long declared the need for an arctic research vessel dedicated to advancing the study of northern ice-dominated seas. Planning for such a vessel began 2 decades ago, but competition for funding has prevented construction. A new design program is underway, and it shows promise of opening up exciting possibilities for new research initiatives in arctic marine science.With its latest design, the Arctic Research Vessel (ARV) has grown to a size and capability that will make it the first U.S. academic research vessel able to provide access to the Arctic Ocean. This ship would open a vast arena for new studies in the least known of the world's seas. These studies promise to rank high in national priority because of the importance of the Arctic Ocean as a source of data relating to global climate change. Other issues that demand attention in the Arctic include its contributions to the world's heat budget, the climate history buried in its sediments, pollution monitoring, and the influence of arctic conditions on marine renewable resources.

Polymethylmethacrylate (PMMA) Material Test Results for the Capillary Flow Experiments (CFE)

NASA Technical Reports Server (NTRS)

Lerch, Bradley A.; Thesken, John C.; Bunnell, Charles T.

2007-01-01

In support of the Capillary Flow Experiments (CFE) program, several polymethylmethacrylate (PMMA) flight vessels were constructed. Some vessels used a multipiece design, which was chemically welded together. Due to questions regarding the effects of the experiment fluid (silicone oil) on the weld integrity, a series of tests were conducted to provide evidence of the adequacy of the current vessel design. Tensile tests were conducted on PMMA samples that were both in the as-received condition, and also aged in air or oil for up to 8 weeks. Both welded and unwelded samples were examined. Fracture of the joints was studied using notched tensile specimens and Brazilian disk tests. Results showed that aging had no effect on tensile properties. While the welded samples were weaker than the base parent material, the weld strength was found to be further degraded by bubbles in the weld zone. Finally a fracture analysis using the worst-case fracture conditions of the vessel was performed, and the vessel design was found to have a factor of three safety margin.

Flood-Ring Formation and Root Development in Response to Experimental Flooding of Young Quercus robur Trees

PubMed Central

Copini, Paul; den Ouden, Jan; Robert, Elisabeth M. R.; Tardif, Jacques C.; Loesberg, Walter A.; Goudzwaard, Leo; Sass-Klaassen, Ute

2016-01-01

Spring flooding in riparian forests can cause significant reductions in earlywood-vessel size in submerged stem parts of ring-porous tree species, leading to the presence of ‘flood rings’ that can be used as a proxy to reconstruct past flooding events, potentially over millennia. The mechanism of flood-ring formation and the relation with timing and duration of flooding are still to be elucidated. In this study, we experimentally flooded 4-year-old Quercus robur trees at three spring phenophases (late bud dormancy, budswell, and internode expansion) and over different flooding durations (2, 4, and 6 weeks) to a stem height of 50 cm. The effect of flooding on root and vessel development was assessed immediately after the flooding treatment and at the end of the growing season. Ring width and earlywood-vessel size and density were measured at 25- and 75-cm stem height and collapsed vessels were recorded. Stem flooding inhibited earlywood-vessel development in flooded stem parts. In addition, flooding upon budswell and internode expansion led to collapsed earlywood vessels below the water level. At the end of the growing season, mean earlywood-vessel size in the flooded stem parts (upon budswell and internode expansion) was always reduced by approximately 50% compared to non-flooded stem parts and 55% compared to control trees. This reduction was already present 2 weeks after flooding and occurred independent of flooding duration. Stem and root flooding were associated with significant root dieback after 4 and 6 weeks and mean radial growth was always reduced with increasing flooding duration. By comparing stem and root flooding, we conclude that flood rings only occur after stem flooding. As earlywood-vessel development was hampered during flooding, a considerable number of narrow earlywood vessels present later in the season, must have been formed after the actual flooding events. Our study indicates that root dieback, together with strongly reduced hydraulic conductivity due to anomalously narrow earlywood vessels in flooded stem parts, contribute to reduced radial growth after flooding events. Our findings support the value of flood rings to reconstruct spring flooding events that occurred prior to instrumental flood records. PMID:27379108

Simulation of Targets Feeding Pipe Rupture in Wendelstein 7-X Facility Using RELAP5 and COCOSYS Codes

NASA Astrophysics Data System (ADS)

Kaliatka, T.; Povilaitis, M.; Kaliatka, A.; Urbonavicius, E.

2012-10-01

Wendelstein nuclear fusion device W7-X is a stellarator type experimental device, developed by Max Planck Institute of plasma physics. Rupture of one of the 40 mm inner diameter coolant pipes providing water for the divertor targets during the "baking" regime of the facility operation is considered to be the most severe accident in terms of the plasma vessel pressurization. "Baking" regime is the regime of the facility operation during which plasma vessel structures are heated to the temperature acceptable for the plasma ignition in the vessel. This paper presents the model of W7-X cooling system (pumps, valves, pipes, hydro-accumulators, and heat exchangers), developed using thermal-hydraulic state-of-the-art RELAP5 Mod3.3 code, and model of plasma vessel, developed by employing the lumped-parameter code COCOSYS. Using both models the numerical simulation of processes in W7-X cooling system and plasma vessel has been performed. The results of simulation showed, that the automatic valve closure time 1 s is the most acceptable (no water hammer effect occurs) and selected area of the burst disk is sufficient to prevent pressure in the plasma vessel.

Automatic retinal blood flow calculation using spectral domain optical coherence tomography

NASA Astrophysics Data System (ADS)

Wehbe, Hassan; Ruggeri, Marco; Jiao, Shuliang; Gregori, Giovanni; Puliafito, Carmen A.

2008-02-01

Optical Doppler tomography (ODT) is a branch of optical coherence tomography (OCT) that can measure the speed of a blood flow by measuring the Doppler shift impinged on the probing sample light by the moving blood cells. However, the measured speed of blood flow is a function of the Doppler angle, which needs to be determined in order to calculate the absolute velocity of the blood flow inside a vessel. We developed a technique that can extract the Doppler angle from the 3D data measured with spectral-domain OCT, which needs to extract the lateral and depth coordinates of a vessel in each measured ODT and OCT image. The lateral coordinates and the diameter of a blood vessel were first extracted in each OCT structural image by using the technique of blood vessel shadowgram, a technique first developed by us for enhancing the retinal blood vessel contrast in the en face view of the 3D OCT. The depth coordinate of a vessel was then determined by using a circular averaging filter moving in the depth direction along the axis passing through the vessel center in the ODT image. The Doppler angle was then calculated from the extracted coordinates of the blood vessel. The technique was applied in blood flow measurements in retinal blood vessels, which has potential impact on the study and diagnosis of blinding diseases like glaucoma and diabetic retinopathy.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Miyashita, Takenori, E-mail: takenori@med.kagawa-u.ac.jp; Burford, James L.; Hong, Young-Kwon

Highlights: •We newly developed the whole-mount imaging method of the tympanic membrane. •Lymphatic vessel loops were localized around the malleus handle and annulus tympanicus. •In regeneration, abundant lymphatic vessels were observed in the pars tensa. •Site-specific lymphatic vessels may play an important role in the tympanic membrane. -- Abstract: We clarified the localization of lymphatic vessels in the tympanic membrane and proliferation of lymphatic vessels during regeneration after perforation of the tympanic membrane by using whole-mount imaging of the tympanic membrane of Prox1 GFP mice. In the pars tensa, lymphatic vessel loops surrounded the malleus handle and annulus tympanicus. Apartmore » from these locations, lymphatic vessel loops were not observed in the pars tensa in the normal tympanic membrane. Lymphatic vessel loops surrounding the malleus handle were connected to the lymphatic vessel loops in the pars flaccida and around the tensor tympani muscle. Many lymphatic vessel loops were detected in the pars flaccida. After perforation of the tympanic membrane, abundant lymphatic regeneration was observed in the pars tensa, and these regenerated lymphatic vessels extended from the lymphatic vessels surrounding the malleus at day 7. These results suggest that site-specific lymphatic vessels play an important role in the tympanic membrane.« less

46 CFR 28.505 - Vessel owner's responsibility.

Code of Federal Regulations, 2011 CFR

2011-10-01

... FISHING INDUSTRY VESSELS Stability § 28.505 Vessel owner's responsibility. (a) Where a test or calculations are necessary to evaluate stability, it is the owner's responsibility to select a qualified individual to perform the test or calculations. (b) Test results and calculations developed in evaluating...

46 CFR 28.505 - Vessel owner's responsibility.

Code of Federal Regulations, 2014 CFR

2014-10-01

... FISHING INDUSTRY VESSELS Stability § 28.505 Vessel owner's responsibility. (a) Where a test or calculations are necessary to evaluate stability, it is the owner's responsibility to select a qualified individual to perform the test or calculations. (b) Test results and calculations developed in evaluating...

46 CFR 28.505 - Vessel owner's responsibility.

Code of Federal Regulations, 2013 CFR

2013-10-01

... FISHING INDUSTRY VESSELS Stability § 28.505 Vessel owner's responsibility. (a) Where a test or calculations are necessary to evaluate stability, it is the owner's responsibility to select a qualified individual to perform the test or calculations. (b) Test results and calculations developed in evaluating...

46 CFR 28.505 - Vessel owner's responsibility.

Code of Federal Regulations, 2010 CFR

2010-10-01

... FISHING INDUSTRY VESSELS Stability § 28.505 Vessel owner's responsibility. (a) Where a test or calculations are necessary to evaluate stability, it is the owner's responsibility to select a qualified individual to perform the test or calculations. (b) Test results and calculations developed in evaluating...

46 CFR 28.505 - Vessel owner's responsibility.

Code of Federal Regulations, 2012 CFR

2012-10-01

... FISHING INDUSTRY VESSELS Stability § 28.505 Vessel owner's responsibility. (a) Where a test or calculations are necessary to evaluate stability, it is the owner's responsibility to select a qualified individual to perform the test or calculations. (b) Test results and calculations developed in evaluating...

Blood Vessel Normalization in the Hamster Oral Cancer Model for Experimental Cancer Therapy Studies

DOE Office of Scientific and Technical Information (OSTI.GOV)

Ana J. Molinari; Romina F. Aromando; Maria E. Itoiz

Normalization of tumor blood vessels improves drug and oxygen delivery to cancer cells. The aim of this study was to develop a technique to normalize blood vessels in the hamster cheek pouch model of oral cancer. Materials and Methods: Tumor-bearing hamsters were treated with thalidomide and were compared with controls. Results: Twenty eight hours after treatment with thalidomide, the blood vessels of premalignant tissue observable in vivo became narrower and less tortuous than those of controls; Evans Blue Dye extravasation in tumor was significantly reduced (indicating a reduction in aberrant tumor vascular hyperpermeability that compromises blood flow), and tumor bloodmore » vessel morphology in histological sections, labeled for Factor VIII, revealed a significant reduction in compressive forces. These findings indicated blood vessel normalization with a window of 48 h. Conclusion: The technique developed herein has rendered the hamster oral cancer model amenable to research, with the potential benefit of vascular normalization in head and neck cancer therapy.« less

Vessel wall characterization using quantitative MRI: what's in a number?

PubMed

Coolen, Bram F; Calcagno, Claudia; van Ooij, Pim; Fayad, Zahi A; Strijkers, Gustav J; Nederveen, Aart J

2018-02-01

The past decade has witnessed the rapid development of new MRI technology for vessel wall imaging. Today, with advances in MRI hardware and pulse sequences, quantitative MRI of the vessel wall represents a real alternative to conventional qualitative imaging, which is hindered by significant intra- and inter-observer variability. Quantitative MRI can measure several important morphological and functional characteristics of the vessel wall. This review provides a detailed introduction to novel quantitative MRI methods for measuring vessel wall dimensions, plaque composition and permeability, endothelial shear stress and wall stiffness. Together, these methods show the versatility of non-invasive quantitative MRI for probing vascular disease at several stages. These quantitative MRI biomarkers can play an important role in the context of both treatment response monitoring and risk prediction. Given the rapid developments in scan acceleration techniques and novel image reconstruction, we foresee the possibility of integrating the acquisition of multiple quantitative vessel wall parameters within a single scan session.

Waterjet processes for coating removal

NASA Technical Reports Server (NTRS)

Burgess, Fletcher; Cosby, Steve; Hoppe, David

1995-01-01

USBI and NASA have been testing and investigating the use of high pressure water for coating removal for approximately the past 12 years at the Automated TPS (Thermal Protection System - ablative materials used for thermal protection during ascent and descent of the solid rocket boosters) Removal Facility located in the Productivity Enhancement Complex at Marshall Space Flight Center. Originally the task was to develop and automate the removal process and transfer the technology to a production facility at Kennedy Space Center. Since that time more and more applications and support roles for the waterjet technology have been realized. The facility has become a vital part of development activities ongoing at MSFC. It supports the development of environmentally compliant insulations, sealants, and coatings. It also supports bonding programs, test motors, and pressure vessels. The most recent role of the cell is supporting Thiokol Corporation's solid rocket motor program in the development of waterjet degreasing and paint stripping methods. Currently vapor degreasing methods use 500,000 lbs. of ozone depleting chemicals per year. This paper describes the major cell equipment, test methods practiced, and coatings that have been removed.

Flow and pressure regulation in the cardiovascular system. [engineering systems model

NASA Technical Reports Server (NTRS)

Iberall, A.

1974-01-01

Principles and descriptive fragments which may contribute to a model of the regulating chains in the cardiovascular system are presented. Attention is given to the strain sensitivity of blood vessels, the law of the autonomy of the heart beat oscillator, the law of the encapsulation of body fluids, the law of the conservation of protein, the law of minimum 'arterial' pressure, the design of the 'mammalian' kidney, questions of homeokinetic organization, and the development of self-regulatory chains. Details concerning the development program for the heart muscle are considered along with the speed of response of the breathing rate and the significance of the pulmonary vascular pressure-flow characteristics.

Collaborative research in cardiovascular dynamics and bone elasticity

NASA Technical Reports Server (NTRS)

1974-01-01

A collaborative research program covering a variety of topics of biomechanics and biomedical engineering within the fields of cardiovascular dynamics, respiration, bone elasticity and vestibular physiology is described. The goals of the research were to promote: (1) a better understanding of the mechanical behavior of the circulatory system and its control mechanisms; (2) development of noninvasive methods of measuring the changes in the mechanical properties of blood vessels and other cardiovascular parameters in man; (3) application of these noninvasive methods to examine in man the physiological effects of environmental changes, including earth-simulated gravitational changes; and (4) development of in-flight methods for studying the events which lead to post-flight postural hypotension.

Pressurized thermal shock: TEMPEST computer code simulation of thermal mixing in the cold leg and downcomer of a pressurized water reactor. [Creare 61 and 64

DOE Office of Scientific and Technical Information (OSTI.GOV)

Eyler, L.L.; Trent, D.S.

The TEMPEST computer program was used to simulate fluid and thermal mixing in the cold leg and downcomer of a pressurized water reactor under emergency core cooling high-pressure injection (HPI), which is of concern to the pressurized thermal shock (PTS) problem. Application of the code was made in performing an analysis simulation of a full-scale Westinghouse three-loop plant design cold leg and downcomer. Verification/assessment of the code was performed and analysis procedures developed using data from Creare 1/5-scale experimental tests. Results of three simulations are presented. The first is a no-loop-flow case with high-velocity, low-negative-buoyancy HPI in a 1/5-scale modelmore » of a cold leg and downcomer. The second is a no-loop-flow case with low-velocity, high-negative density (modeled with salt water) injection in a 1/5-scale model. Comparison of TEMPEST code predictions with experimental data for these two cases show good agreement. The third simulation is a three-dimensional model of one loop of a full size Westinghouse three-loop plant design. Included in this latter simulation are loop components extending from the steam generator to the reactor vessel and a one-third sector of the vessel downcomer and lower plenum. No data were available for this case. For the Westinghouse plant simulation, thermally coupled conduction heat transfer in structural materials is included. The cold leg pipe and fluid mixing volumes of the primary pump, the stillwell, and the riser to the steam generator are included in the model. In the reactor vessel, the thermal shield, pressure vessel cladding, and pressure vessel wall are thermally coupled to the fluid and thermal mixing in the downcomer. The inlet plenum mixing volume is included in the model. A 10-min (real time) transient beginning at the initiation of HPI is computed to determine temperatures at the beltline of the pressure vessel wall.« less

A Computational Model Predicting Disruption of Blood Vessel Development

EPA Science Inventory

Vascular development is a complex process regulated by dynamic biological networks that vary in topology and state across different tissues and developmental stages. Signals regulating de novo blood vessel formation (vasculogenesis) and remodeling (angiogenesis) come from a varie...

Vascular pericyte density and angiogenesis associated with adenocarcinoma of the prostate.

PubMed

Killingsworth, Murray C; Wu, Xiaojuan

2011-01-01

Angiogenesis facilitates metabolism, proliferation and metastasis of adenocarcinoma cells in the prostate, as without the development of new vasculature tumor growth cannot be sustained. However, angiogenesis is variable with the well-known phenomenon of vascular 'hotspots' seen associated with viable tumor cell mass. With the recent recognition of pericytes as molecular regulators of angiogenesis, we have examined the interaction of these cells in actively growing new vessels. Pericyte interactions with developing new vessels were examined using transmission electron microscopy. Pericyte distribution was mapped from α-SMA+ immunostained histological sections and quantified using image analysis. Data was obtained from peripheral and more central regions of 27 cases with Gleason scores of 4-9. Pericyte numbers were increased around developing new vessel sprouts at sites of luminal maturation. Numbers were reduced around the actively growing tips of migrating endothelial cells and functional new vessels. Tumor regions internal to a 500-μm peripheral band showed higher microvessel pericyte density than the peripheral region. Pericytes were found to be key cellular components of developing new vessels in adenocarcinoma of the prostate. Their numbers increased at sites of luminal maturation with these cells displaying an activated phenotype different to quiescent pericytes. Increased pericyte density was found internal to the peripheral region, suggesting more mature vessels lie more centrally. Copyright © 2011 S. Karger AG, Basel.

Uniform system of traffic guidance on European inland waterways : guidelines and criteria for vessel traffic service in inland waters

DOT National Transportation Integrated Search

2003-03-11

The International Maritime Organization (IMO) has developed guidelines on the principles and general operational provisions for the operation of a vessel traffic service (VTS).However, these guidelines only address seagoing vessels that have to compl...

Pulmonary vessel segmentation utilizing curved planar reformation and optimal path finding (CROP) in computed tomographic pulmonary angiography (CTPA) for CAD applications

NASA Astrophysics Data System (ADS)

Zhou, Chuan; Chan, Heang-Ping; Kuriakose, Jean W.; Chughtai, Aamer; Wei, Jun; Hadjiiski, Lubomir M.; Guo, Yanhui; Patel, Smita; Kazerooni, Ella A.

2012-03-01

Vessel segmentation is a fundamental step in an automated pulmonary embolism (PE) detection system. The purpose of this study is to improve the segmentation scheme for pulmonary vessels affected by PE and other lung diseases. We have developed a multiscale hierarchical vessel enhancement and segmentation (MHES) method for pulmonary vessel tree extraction based on the analysis of eigenvalues of Hessian matrices. However, it is difficult to segment the pulmonary vessels accurately under suboptimal conditions, such as vessels occluded by PEs, surrounded by lymphoid tissues or lung diseases, and crossing with other vessels. In this study, we developed a new vessel refinement method utilizing curved planar reformation (CPR) technique combined with optimal path finding method (MHES-CROP). The MHES segmented vessels straightened in the CPR volume was refined using adaptive gray level thresholding where the local threshold was obtained from least-square estimation of a spline curve fitted to the gray levels of the vessel along the straightened volume. An optimal path finding method based on Dijkstra's algorithm was finally used to trace the correct path for the vessel of interest. Two and eight CTPA scans were randomly selected as training and test data sets, respectively. Forty volumes of interest (VOIs) containing "representative" vessels were manually segmented by a radiologist experienced in CTPA interpretation and used as reference standard. The results show that, for the 32 test VOIs, the average percentage volume error relative to the reference standard was improved from 32.9+/-10.2% using the MHES method to 9.9+/-7.9% using the MHES-CROP method. The accuracy of vessel segmentation was improved significantly (p<0.05). The intraclass correlation coefficient (ICC) of the segmented vessel volume between the automated segmentation and the reference standard was improved from 0.919 to 0.988. Quantitative comparison of the MHES method and the MHES-CROP method with the reference standard was also evaluated by the Bland-Altman plot. This preliminary study indicates that the MHES-CROP method has the potential to improve PE detection.

Digital image processing of vascular angiograms

NASA Technical Reports Server (NTRS)

Selzer, R. H.; Beckenbach, E. S.; Blankenhorn, D. H.; Crawford, D. W.; Brooks, S. H.

1975-01-01

The paper discusses the estimation of the degree of atherosclerosis in the human femoral artery through the use of a digital image processing system for vascular angiograms. The film digitizer uses an electronic image dissector camera to scan the angiogram and convert the recorded optical density information into a numerical format. Another processing step involves locating the vessel edges from the digital image. The computer has been programmed to estimate vessel abnormality through a series of measurements, some derived primarily from the vessel edge information and others from optical density variations within the lumen shadow. These measurements are combined into an atherosclerosis index, which is found in a post-mortem study to correlate well with both visual and chemical estimates of atherosclerotic disease.

Flt-1 (VEGFR-1) coordinates discrete stages of blood vessel formation

PubMed Central

Chappell, John C.; Cluceru, Julia G.; Nesmith, Jessica E.; Mouillesseaux, Kevin P.; Bradley, Vanessa B.; Hartland, Caitlin M.; Hashambhoy-Ramsay, Yasmin L.; Walpole, Joseph; Peirce, Shayn M.; Mac Gabhann, Feilim; Bautch, Victoria L.

2016-01-01

Aims In developing blood vessel networks, the overall level of vessel branching often correlates with angiogenic sprout initiations, but in some pathological situations, increased sprout initiations paradoxically lead to reduced vessel branching and impaired vascular function. We examine the hypothesis that defects in the discrete stages of angiogenesis can uniquely contribute to vessel branching outcomes. Methods and results Time-lapse movies of mammalian blood vessel development were used to define and quantify the dynamics of angiogenic sprouting. We characterized the formation of new functional conduits by classifying discrete sequential stages—sprout initiation, extension, connection, and stability—that are differentially affected by manipulation of vascular endothelial growth factor-A (VEGF-A) signalling via genetic loss of the receptor flt-1 (vegfr1). In mouse embryonic stem cell-derived vessels genetically lacking flt-1, overall branching is significantly decreased while sprout initiations are significantly increased. Flt-1−/− mutant sprouts are less likely to retract, and they form increased numbers of connections with other vessels. However, loss of flt-1 also leads to vessel collapse, which reduces the number of new stable conduits. Computational simulations predict that loss of flt-1 results in ectopic Flk-1 signalling in connecting sprouts post-fusion, causing protrusion of cell processes into avascular gaps and collapse of branches. Thus, defects in stabilization of new vessel connections offset increased sprout initiations and connectivity in flt-1−/− vascular networks, with an overall outcome of reduced numbers of new conduits. Conclusions These results show that VEGF-A signalling has stage-specific effects on vascular morphogenesis, and that understanding these effects on dynamic stages of angiogenesis and how they integrate to expand a vessel network may suggest new therapeutic strategies. PMID:27142980

NATO Advanced Research Workshop on Non-Thermal Plasma Techniques for Pollution Control Held in England on September 21 - 25, 1992. Program and Abstracts

DTIC Science & Technology

1992-09-25

2100 DINNER NATO ADVANCED RESEARCH WORKSHOP ON NON-THERMAL PLASMA TECHNIQUES FOR POLLUTION CONTR" OL SCHEDULE Friday Morning, September 25 1 5...vessel, leading to the decrease of the concentrations of 502 and ammonia, and deposition of white powdery material on the inner surface of the vessel. From...discharges (silent discharges) revealed that in certain gas mixtures discharge conditions can be established that favour the formation of excimer or exciplex

Occipital foramina development involves localised regulation of mesenchyme proliferation and is independent of apoptosis

PubMed Central

Akbareian, Sophia E; Pitsillides, Andrew A; Macharia, Raymond G; McGonnell, Imelda M

2015-01-01

Cranial foramina are holes within the skull, formed during development, allowing entry and exit of blood vessels and nerves. Once formed they must remain open, due to the vital structures they contain, i.e. optic nerves, jugular vein, carotid artery, and other cranial nerves and blood vessels. Understanding cranial foramina development is essential as cranial malformations lead to the stenosis or complete closure of these structures, resulting in blindness, deafness, facial paralysis, raised intracranial pressure and lethality. Here we focus on describing early events in the formation of the jugular, carotid and hypoglossal cranial foramina that form in the mesoderm-derived, endochondral occipital bones at the base of the embryonic chick skull. Whole-mount skeletal staining of skulls indicates the appearance of these foramina from HH32/D7.5 onwards. Haematoxylin & eosin staining of sections shows that the intimately associated mesenchyme, neighbouring the contents of these cranial foramina, is initially very dense and gradually becomes sparser as development proceeds. Histological examination also revealed that these foramina initially contain relatively large-diameter nerves, which later become refined, and are closely associated with the blood vessel, which they also innervate within the confines of the foramina. Interestingly cranial foramina in the base of the skull contain blood vessels lacking smooth muscle actin, which suggests these blood vessels belong to glomus body structures within the foramina. The blood vessel shape also appears to dictate the overall shape of the resulting foramina. We initially hypothesised that cranial foramina development could involve targeted proliferation and local apoptosis to cause ‘mesenchymal clearing’ and the creation of cavities in a mechanism similar to joint cavitation. We find that this is not the case, and propose that a mechanism reliant upon local nerve/blood vessel-derived restriction of ossification may contribute to foramina formation during cranial development. PMID:25994127

75 FR 53953 - The National Saltwater Angler Registry Program; Designation of Exempted States for Anglers, Spear...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-09-02

... DEPARTMENT OF COMMERCE National Oceanic and Atmospheric Administration RIN 0648-XX66 The National Saltwater Angler Registry Program; Designation of Exempted States for Anglers, Spear Fishers, and For-Hire... as exempted states for anglers, spear fishers and for-hire fishing vessels. NMFS has designated the...

50 CFR 679.84 - Rockfish Program recordkeeping, permits, monitoring, and catch accounting.

Code of Federal Regulations, 2013 CFR

2013-10-01

... must be within or adjacent to the observer sample station. (7) Pre-cruise meeting. The Observer Program... arrange for a pre-cruise meeting. The pre-cruise meeting must minimally include the vessel operator or... shoreside processors—(1) Catch monitoring and control plan (CMCP). The owner or operator of a shoreside...

50 CFR 679.84 - Rockfish Program recordkeeping, permits, monitoring, and catch accounting.

Code of Federal Regulations, 2014 CFR

2014-10-01

... must be within or adjacent to the observer sample station. (7) Pre-cruise meeting. The Observer Program... arrange for a pre-cruise meeting. The pre-cruise meeting must minimally include the vessel operator or... shoreside processors—(1) Catch monitoring and control plan (CMCP). The owner or operator of a shoreside...

50 CFR 679.84 - Rockfish Program recordkeeping, permits, monitoring, and catch accounting.

Code of Federal Regulations, 2012 CFR

2012-10-01

... must be within or adjacent to the observer sample station. (7) Pre-cruise meeting. The Observer Program... arrange for a pre-cruise meeting. The pre-cruise meeting must minimally include the vessel operator or... shoreside processors—(1) Catch monitoring and control plan (CMCP). The owner or operator of a shoreside...

NASA NDE Program

NASA Technical Reports Server (NTRS)

Generazio, Ed; Burke, Eric

2015-01-01

The current activities in the National Aeronautics and Space Administration Nondestructive Evaluation (NDE) Program are presented. The topics covered include organizational communications, orbital weld inspection, electric field imaging, fracture critical probability of detection validation, monitoring of thermal protection systems, physical and document standards, image quality indicators, integrity of composite pressure vessels, and NDE for additively manufactured components.

Ultrasound Dopplerography of abdomen pathology using statistical computer programs

NASA Astrophysics Data System (ADS)

Dmitrieva, Irina V.; Arakelian, Sergei M.; Wapota, Alberto R. W.

1998-04-01

The modern ultrasound dopplerography give us the big possibilities in investigation of gemodynamical changes in all stages of abdomen pathology. Many of researches devoted to using of noninvasive methods in practical medicine. Now ultrasound Dopplerography is one of the basic one. We investigated 250 patients from 30 to 77 ages, including 149 men and 101 women. The basic diagnosis of all patients was the Ischaemic Pancreatitis. The Second diagnoses of pathology were the Ischaemic Disease of Heart, Gypertension, Atherosclerosis, Diabet, Vascular Disease of Extremities. We researched the abdominal aorta and her branches: Arteria Mesenterica Superior (AMS), truncus coeliacus (TC), arteria hepatica communis (AHC), arteria lienalis (AL). For investigation we use the following equipment: ACUSON 128 XP/10c, BIOMEDIC, GENERAL ELECTRIC (USA, Japan). We analyzed the following componetns of gemodynamical changes of abdominal vessels: index of pulsation, index of resistance, ratio of systol-dystol, speed of blood circulation. Statistical program included the following one: 'basic statistic's,' 'analytic program.' In conclusion we determined that the all gemodynamical components of abdominal vessels had considerable changes in abdominal ischaemia than in normal situation. Using the computer's program for definition degree of gemodynamical changes, we can recommend the individual plan of diagnostical and treatment program.

An overview of lymphatic vessels and their emerging role in cardiovascular disease

PubMed Central

Jones, Dennis; Min, Wang

2011-01-01

Over the past decade, molecular details of lymphatic vessels (lymphatics) have been rapidly acquired due to the identification of lymphatic endothelial-specific markers. Separate from the cardiovascular system, the lymphatic system is also an elaborate network of vessels that are important in normal physiology. Lymphatic vessels have the unique task to regulate fluid homeostasis, assist in immune surveillance, and transport dietary lipids. However, dysfunctional lymphatic vessels can cause pathology, while normal lymphatics can exacerbate pathology. This review summarizes the development and growth of lymphatic vessels in addition to highlighting their critical roles in physiology and pathology. Also, we discuss recent work that suggests a connection between lymphatic dysfunction and cardiovascular disease. PMID:22022141

Effects of a Social Welfare Program for Health Promotion on Cardiovascular Risk Factors.

PubMed

Choi, Seong-Jin; Chang, Jae Seung; Kong, In Deok

2015-09-01

Socioeconomic status is closely associated with an individual's health status. However, there are few studies examining the role of exercise-training as part of a community-based social welfare program in socially vulnerable groups. Given this, our aim was to measure whether long-term exercise training as a social welfare program affects the prevalence of depressive symptoms, metabolic syndrome and peripheral blood vessel condition among participants with low household income. Twenty-nine adults and twenty-two older adults were recruited into this study with non-radomized, pre/post-test design. The subjects underwent a combined training consisting of aerobic and muscle strengthening exercises for 6 months or more. Depressive symptoms were evaluated using the Beck Depression Inventory and the Korean version of Geriatric Depression Scale. Metabolic syndrome was defined according to the International Diabetes Federation criteria. Blood vessel condition was assessed using non-invasive accelerated photoplethysmograph. Mean skeletal muscle mass increased after exercise-training, but body mass index and percent body fat were unchanged. Overall age-specific physical fitness and performance increased markedly among both adult and elderly subjects, respectively. The proportion of depressive symptoms was significantly reduced by 33% after exercise-training among all participants. The prevalence of individuals having metabolic syndrome was significantly reduced by 19.6% and the number of individual components of metabolic syndrome decreased after the exercise intervention. Among components of metabolic syndrome, waist circumference, HDL cholesterol and systolic blood pressure significantly improved. In addition, the proportions of moderate and severe arteriosclerotic progression significantly decreased. Long-term exercise-training as a social welfare program is beneficial for health promotion and effective in simultaneously improving psychological and physiological health status in a low income population. This suggests that the development and expansion of an exercise intervention as a health-promoting welfare program are needed to address the inequality of exercise participation among socially vulnerable groups.

Fluid Vessel Quantity using Non-Invasive PZT Technology Flight Volume Measurements Under Zero G Analysis

NASA Technical Reports Server (NTRS)

Garofalo, Anthony A.

2013-01-01

The purpose of the project is to perform analysis of data using the Systems Engineering Educational Discovery (SEED) program data from 2011 and 2012 Fluid Vessel Quantity using Non-Invasive PZT Technology flight volume measurements under Zero G conditions (parabolic Plane flight data). Also experimental planning and lab work for future sub-orbital experiments to use the NASA PZT technology for fluid volume measurement. Along with conducting data analysis of flight data, I also did a variety of other tasks. I provided the lab with detailed technical drawings, experimented with 3d printers, made changes to the liquid nitrogen skid schematics, and learned how to weld. I also programmed microcontrollers to interact with various sensors and helped with other things going on around the lab.

Fluid Vessel Quantity Using Non-invasive PZT Technology Flight Volume Measurements Under Zero G Analysis

NASA Technical Reports Server (NTRS)

Garofalo, Anthony A

2013-01-01

The purpose of the project is to perform analysis of data using the Systems Engineering Educational Discovery (SEED) program data from 2011 and 2012 Fluid Vessel Quantity using Non-Invasive PZT Technology flight volume measurements under Zero G conditions (parabolic Plane flight data). Also experimental planning and lab work for future sub-orbital experiments to use the NASA PZT technology for fluid volume measurement. Along with conducting data analysis of flight data, I also did a variety of other tasks. I provided the lab with detailed technical drawings, experimented with 3d printers, made changes to the liquid nitrogen skid schematics, and learned how to weld. I also programmed microcontrollers to interact with various sensors and helped with other things going on around the lab.

NG2 glia are required for vessel network formation during embryonic development

PubMed Central

Minocha, Shilpi; Valloton, Delphine; Brunet, Isabelle; Eichmann, Anne

2015-01-01

The NG2+ glia, also known as polydendrocytes or oligodendrocyte precursor cells, represent a new entity among glial cell populations in the central nervous system. However, the complete repertoire of their roles is not yet identified. The embryonic NG2+ glia originate from the Nkx2.1+ progenitors of the ventral telencephalon. Our analysis unravels that, beginning from E12.5 until E16.5, the NG2+ glia populate the entire dorsal telencephalon. Interestingly, their appearance temporally coincides with the establishment of blood vessel network in the embryonic brain. NG2+ glia are closely apposed to developing cerebral vessels by being either positioned at the sprouting tip cells or tethered along the vessel walls. Absence of NG2+ glia drastically affects the vascular development leading to severe reduction of ramifications and connections by E18.5. By revealing a novel and fundamental role for NG2+ glia, our study brings new perspectives to mechanisms underlying proper vessels network formation in embryonic brains. DOI: http://dx.doi.org/10.7554/eLife.09102.001 PMID:26651999

Blood vessel crosstalk during organogenesis – Focus on Pancreas

PubMed Central

Azizoglu, D. Berfin; Cleaver, Ondine

2016-01-01

Blood vessels form a highly branched, interconnected and largely stereotyped network of tubes that sustains every organ and tissue in vertebrates. How vessels come to take on their particular architecture, or how they are ‘patterned’, and in turn, how they influence surrounding tissues are fundamental questions of organogenesis. Decades of work have begun to elucidate how endothelial progenitors arise and home to precise locations within tissues, integrating attractive and repulsive cues to build vessels where they are needed. Conversely, more recent findings have revealed an exciting facet of blood vessel interaction with tissues, where vascular cells provide signals to developing organs and progenitors therein. Here, we discuss the exchange of reciprocal signals between endothelial cells (ECs) and neighboring tissues during embryogenesis, with a special focus on the developing pancreas. Understanding the mechanisms driving both sides of these interactions will be crucial to the development of therapies, from improving organ regeneration to efficient production of cell based therapies. Specifically, elucidating the interface of the vasculature with pancreatic lineages, including endocrine cells, will instruct approaches such as generation of replacement beta cells for Type I diabetes. PMID:27328421

Vascular development in the vertebrate pancreas

PubMed Central

Azizoglu, D. Berfin; Chong, Diana C.; Villasenor, Alethia; Magenheim, Judith; Barry, David M.; Lee, Simon; Marty-Santos, Leilani; Fu, Stephen; Dor, Yuval; Cleaver, Ondine

2016-01-01

The vertebrate pancreas is comprised of a highly branched tubular epithelium, which is intimately associated with an extensive and specialized vasculature. While we know a great deal about basic vascular anatomy of the adult pancreas, as well as islet capillaries, surprisingly little is known about the ontogeny of its blood vessels. Here, we analyze development of the pancreatic vasculature in the mouse embryo. We show that pancreatic epithelial branches intercalate with the fine capillary plexus of the surrounding pancreatic mesenchyme. Endothelial cells (ECs) within this mesenchyme are heterogeneous from the onset of organogenesis. Pancreatic arteries take shape before veins, in a manner analogous to early embryonic vessels. The main central artery forms during mid-gestation, as a result of vessel coalescence and remodeling of a vascular plexus. In addition, we show that vessels in the forming pancreas display a predictable architecture that is dependent on VEGF signaling. Over-expression of VEGF disrupts vascular patterning and arteriovenous differentiation within the developing pancreas. This study constitutes a first-time cellular and molecular characterization of pancreatic blood vessels, as they coordinately grow along with the pancreatic epithelium. PMID:27789228

A new fundamental bioheat equation for muscle tissue--part II: Temperature of SAV vessels.

PubMed

Zhu, Liang; Xu, Lisa X; He, Qinghong; Weinbaum, Sheldon

2002-02-01

In this study, a new theoretical framework was developed to investigate temperature variations along countercurrent SAV blood vessels from 300 to 1000 microm diameter in skeletal muscle. Vessels of this size lie outside the range of validity of the Weinbaum-Jiji bioheat equation and, heretofore, have been treated using discrete numerical methods. A new tissue cylinder surrounding these vessel pairs is defined based on vascular anatomy, Murray's law, and the assumption of uniform perfusion. The thermal interaction between the blood vessel pair and surrounding tissue is investigated for two vascular branching patterns, pure branching and pure perfusion. It is shown that temperature variations along these large vessel pairs strongly depend on the branching pattern and the local blood perfusion rate. The arterial supply temperature in different vessel generations was evaluated to estimate the arterial inlet temperature in the modified perfusion source term for the s vessels in Part I of this study. In addition, results from the current research enable one to explore the relative contribution of the SAV vessels and the s vessels to the overall thermal equilibration between blood and tissue.

FloWave.US: validated, open-source, and flexible software for ultrasound blood flow analysis.

PubMed

Coolbaugh, Crystal L; Bush, Emily C; Caskey, Charles F; Damon, Bruce M; Towse, Theodore F

2016-10-01

Automated software improves the accuracy and reliability of blood velocity, vessel diameter, blood flow, and shear rate ultrasound measurements, but existing software offers limited flexibility to customize and validate analyses. We developed FloWave.US-open-source software to automate ultrasound blood flow analysis-and demonstrated the validity of its blood velocity (aggregate relative error, 4.32%) and vessel diameter (0.31%) measures with a skeletal muscle ultrasound flow phantom. Compared with a commercial, manual analysis software program, FloWave.US produced equivalent in vivo cardiac cycle time-averaged mean (TAMean) velocities at rest and following a 10-s muscle contraction (mean bias <1 pixel for both conditions). Automated analysis of ultrasound blood flow data was 9.8 times faster than the manual method. Finally, a case study of a lower extremity muscle contraction experiment highlighted the ability of FloWave.US to measure small fluctuations in TAMean velocity, vessel diameter, and mean blood flow at specific time points in the cardiac cycle. In summary, the collective features of our newly designed software-accuracy, reliability, reduced processing time, cost-effectiveness, and flexibility-offer advantages over existing proprietary options. Further, public distribution of FloWave.US allows researchers to easily access and customize code to adapt ultrasound blood flow analysis to a variety of vascular physiology applications. Copyright © 2016 the American Physiological Society.

Evaluation on the Feasibility of Using Ultrasonic Testing of Reactor Pressure Vessel Welds for Assessing Flaw Density/Distribution per 10 CFR 50.61a, Alternate Fracture Toughness Requirements for Protection Against Pressurized Thermal Shock

DOE Office of Scientific and Technical Information (OSTI.GOV)

Sullivan, Edmund J.; Anderson, Michael T.

2014-06-10

This technical letter report provides the status of an assessment undertaken by PNNL at the request of the NRC to verify the capability of periodic ASME-required volumetric examinations of reactor vessels to characterize the density and distribution of flaws of interest for applying §50.61a on a plant-by-plant basis. The PTS rule, described in the Code of Federal Regulations, Title 10, Section 50.61 (§50.61), "Fracture Toughness Requirements for Protection against Pressurized Thermal Shock Events," establishes screening criteria to ensure that the potential for a reactor vessel to fail due to a PTS event is deemed to be acceptably low. Recently, themore » NRC completed a research program that concluded that the risk of through-wall cracking due to a PTS event is much lower than previously estimated. The NRC subsequently developed and promulgated an alternate PTS rule, §50.61a, that can be implemented by PWR licensees. The §50.61a rule differs from §50.61 in that it requires licensees who choose to follow this alternate method to analyze the results from periodic volumetric examinations required by the ASME Code, Section XI, Rules for Inservice Inspection (ISI) of Nuclear Power Plants.« less

Noninvasively measuring oxygen saturation of human finger-joint vessels by multi-transducer functional photoacoustic tomography

NASA Astrophysics Data System (ADS)

Deng, Zijian; Li, Changhui

2016-06-01

Imaging small blood vessels and measuring their functional information in finger joint are still challenges for clinical imaging modalities. In this study, we developed a multi-transducer functional photoacoustic tomography (PAT) system and successfully imaged human finger-joint vessels from ˜1 mm to <0.2 mm in diameter. In addition, the oxygen saturation (SO2) values of these vessels were also measured. Our results demonstrate that PAT can provide both anatomical and functional information of individual finger-joint vessels with different sizes, which might help the study of finger-joint diseases, such as rheumatoid arthritis.

Interaction of Vascular Smooth Muscle Cells Under Low Shear Stress

NASA Technical Reports Server (NTRS)

Seidel, Charles L.

1998-01-01

The blood vessel wall consists of three cellular layers, an outer adventitial, a middle medial and an inner intimal layer. When the blood vessel forms in the embryo it begins as a tube composed of a single cell type called endothelial cells. Over time, other cells are recruited from the surrounding tissue to form additional layers on the outer surface of the endothelial tube. The cells that are recruited are called mesenchymal cells. Mesenchymal cells are responsible for the production of connective tissue that holds the blood vessel together and for developing into vascular smooth muscle cells that are responsible for regulating the diameter of the vessel (1) and therefore, blood flow. In a fully developed blood vessel, the endothelial cells make- up the majority of cells in the intimal layer while the mesenchymal cells make-up the majority of cells in the medial and adventitial layers. Within the medial layer of a mature vessel, cells are organized into multiple circular layers of alternating bands of connective tissue and cells. The cell layer is composed of a mixture of mesenchymal cells that have not developed into smooth muscle cells and fully developed smooth muscle cells (2). The assembly and organization of complex tissues is directed in part by a signaling system composed of proteins on the cell surface called adhesion molecules. Adhesion molecules enable cells to recognize each other as well as the composition of the connective tissue in which they reside (3). It was hypothesized that the different cell types that compose the vascular wall possess different adhesion molecules that enable them to recognize each other and through this recognition system, form the complex layered organization of the vascular wall. In other words, the layered organization is an intrinsic property of the cells. If this hypothesis is correct then the different cells that make up the vessel wall, when mixed together, should organize themselves into a layered structure resembling an intact blood vessel. Experiments described below were designed to test this hypothesis.

Smooth muscle cell seeding of decellularized scaffolds: the importance of bioreactor preconditioning to development of a more native architecture for tissue-engineered blood vessels.

PubMed

Yazdani, Saami K; Watts, Benjamin; Machingal, Masood; Jarajapu, Yagna P R; Van Dyke, Mark E; Christ, George J

2009-04-01

Vascular smooth muscle cells (VSMCs) impart important functional characteristics in the native artery and, therefore, should logically be incorporated in the development of tissue-engineered blood vessels. However, the native architecture and low porosity of naturally derived biomaterials (i.e., decellularized vessels) have impeded efforts to seed and incorporate a VSMC layer in tissue-engineered blood vessels. To this end, the goal of this study was to develop improved methods for seeding, proliferation, and maturation of VSMCs on decellularized porcine carotid arteries. Decellularized vessels were prepared in the absence and presence of the adventitial layer, and statically seeded with a pipette containing a suspension of rat aortic VSMCs. After cell seeding, recellularized engineered vessels were placed in a custom bioreactor system for 1-2 weeks to enhance cellular proliferation, alignment, and maturation. Initial attachment of VSMCs was dramatically enhanced by removing the adventitial layer of the decellularized porcine artery. Moreover, cyclic bioreactor conditioning (i.e., flow and pressure) resulted in increased VSMC proliferation and accelerated formation of a muscularized medial layer in the absence of the adventitial layer during the first week of preconditioning. Fura-2-based digital imaging microscopy revealed marked and reproducible depolarization-induced calcium mobilization after bioreactor preconditioning in the absence, but not in the presence, of the adventitia. The major finding of this investigation is that bioreactor preconditioning accelerates the formation of a significant muscular layer on decellularized scaffolds, in particular on adventitia-denuded scaffolds. Further, the VSMC layer of bioreactor-preconditioned vessels was capable of mobilizing calcium in response to cellular depolarization. These findings represent an important first step toward the development of tissue-engineered vascular grafts that more closely mimic native vasculature.

49 CFR 237.105 - Special inspections.

Code of Federal Regulations, 2012 CFR

2012-10-01

...) Each bridge management program shall prescribe a procedure for protection of train operations and for... limited to a flood, fire, earthquake, derailment or vehicular or vessel impact. (b) Each bridge management...

49 CFR 237.105 - Special inspections.

Code of Federal Regulations, 2014 CFR

2014-10-01

...) Each bridge management program shall prescribe a procedure for protection of train operations and for... limited to a flood, fire, earthquake, derailment or vehicular or vessel impact. (b) Each bridge management...

49 CFR 237.105 - Special inspections.

Code of Federal Regulations, 2013 CFR

2013-10-01

...) Each bridge management program shall prescribe a procedure for protection of train operations and for... limited to a flood, fire, earthquake, derailment or vehicular or vessel impact. (b) Each bridge management...

49 CFR 237.105 - Special inspections.

Code of Federal Regulations, 2010 CFR

2010-10-01

...) Each bridge management program shall prescribe a procedure for protection of train operations and for... limited to a flood, fire, earthquake, derailment or vehicular or vessel impact. (b) Each bridge management...

49 CFR 237.105 - Special inspections.

Code of Federal Regulations, 2011 CFR

2011-10-01

...) Each bridge management program shall prescribe a procedure for protection of train operations and for... limited to a flood, fire, earthquake, derailment or vehicular or vessel impact. (b) Each bridge management...

Histological evaluation and optimization of surgical vessel sealing systems

NASA Astrophysics Data System (ADS)

Lathrop, Robert; Ryan, Thomas; Gaspredes, Jonathan; Woloszko, Jean; Coad, James E.

2017-02-01

Surgical vessel sealing systems are widely used to achieve hemostasis and dissection in open surgery and minimally invasive, laparoscopic surgery. This enabling technology was developed about 17 years ago and continues to evolve with new devices and systems achieving improved outcomes. Histopathological assessment of thermally sealed tissues is a valuable tool for refining and comparing performance among surgical vessel sealing systems. Early work in this field typically assessed seal time, burst rate, and failure rate (in-situ). Later work compared histological staining methods with birefringence to assess the extent of thermal damage to tissues adjacent to the device. Understanding the microscopic architecture of a sealed vessel is crucial to optimizing the performance of power delivery algorithms and device design parameters. Manufacturers rely on these techniques to develop new products. A system for histopathological evaluation of vessels and sealing performance was established, to enable the direct assessment of a treatment's tissue effects. The parameters included the commonly used seal time, pressure burst rate and failure rate, as well as extensions of the assessment to include its likelihood to form steam vacuoles, adjacent thermal effect near the device, and extent of thermally affected tissue extruded back into the vessel lumen. This comprehensive assessment method provides an improved means of assessing the quality of a sealed vessel and understanding the exact mechanisms which create an optimally sealed vessel.

Automated tracking and quantification of angiogenic vessel formation in 3D microfluidic devices.

PubMed

Wang, Mengmeng; Ong, Lee-Ling Sharon; Dauwels, Justin; Asada, H Harry

2017-01-01

Angiogenesis, the growth of new blood vessels from pre-existing vessels, is a critical step in cancer invasion. Better understanding of the angiogenic mechanisms is required to develop effective antiangiogenic therapies for cancer treatment. We culture angiogenic vessels in 3D microfluidic devices under different Sphingosin-1-phosphate (S1P) conditions and develop an automated vessel formation tracking system (AVFTS) to track the angiogenic vessel formation and extract quantitative vessel information from the experimental time-lapse phase contrast images. The proposed AVFTS first preprocesses the experimental images, then applies a distance transform and an augmented fast marching method in skeletonization, and finally implements the Hungarian method in branch tracking. When applying the AVFTS to our experimental data, we achieve 97.3% precision and 93.9% recall by comparing with the ground truth obtained from manual tracking by visual inspection. This system enables biologists to quantitatively compare the influence of different growth factors. Specifically, we conclude that the positive S1P gradient increases cell migration and vessel elongation, leading to a higher probability for branching to occur. The AVFTS is also applicable to distinguish tip and stalk cells by considering the relative cell locations in a branch. Moreover, we generate a novel type of cell lineage plot, which not only provides cell migration and proliferation histories but also demonstrates cell phenotypic changes and branch information.

Summary of Activities for Health Monitoring of Composite Overwrapped Pressure Vessels

NASA Technical Reports Server (NTRS)

Russell, Rick

2012-01-01

This new start project (FY12-14) will design and demonstrate the ability of nondestructive evaluation sensors for the measurement of stresses on the inner diameter of a Composite Overwrapped Pressure Vessel overwrap. Results will be correlated with other nondestructive evaluation technologies such as Acoustic Emission. The project will build upon a proof of concept study performed at KSC which demonstrated the ability of Magnetic Stress Gages to measure stresses at internal overwraps and upon current acoustic emission research being performed at WSTF; The gages will be produced utilizing Maundering Winding Magnetometer and/or Maundering Winding Magnetometer-array eddy current technology. The proof-of-concept study demonstrated a correlation between the sensor response and pressure or strain. The study also demonstrated the ability of Maundering Winding Magnetometer technology to monitor the stresses in a Composite Overwrapped Pressure Vessel at different orientations and depths. The ultimate goal is to utilize this technology for the health monitoring of Composite Overwrapped Pressure Vessels for all future flight programs.

Occupational Safety and Health Conditions Aboard Small- and Medium-Size Fishing Vessels: Differences among Age Groups.

PubMed

Zytoon, Mohamed A; Basahel, Abdulrahman M

2017-02-24

Although marine fishing is one of the most hazardous occupations, research on the occupational safety and health (OSH) conditions aboard marine fishing vessels is scarce. For instance, little is known about the working conditions of vulnerable groups such as young and aging fishermen. The objective of the current paper is to study the OSH conditions of young and aging fishermen compared to middle-aged fishermen in the small- and medium-size (SM) marine fishing sector. A cross-sectional study was designed, and 686 fishermen working aboard SM fishing vessels were interviewed to collect information about their safety and health. The associations of physical and psychosocial work conditions with safety and health outcomes, e.g., injuries, illnesses and job satisfaction, are presented. The results of the current study can be utilized in the design of effective accident prevention and OSH training programs for the three age groups and in the regulation of working conditions aboard fishing vessels.

Occupational Safety and Health Conditions Aboard Small- and Medium-Size Fishing Vessels: Differences among Age Groups

PubMed Central

Zytoon, Mohamed A.; Basahel, Abdulrahman M.

2017-01-01

Although marine fishing is one of the most hazardous occupations, research on the occupational safety and health (OSH) conditions aboard marine fishing vessels is scarce. For instance, little is known about the working conditions of vulnerable groups such as young and aging fishermen. The objective of the current paper is to study the OSH conditions of young and aging fishermen compared to middle-aged fishermen in the small- and medium-size (SM) marine fishing sector. A cross-sectional study was designed, and 686 fishermen working aboard SM fishing vessels were interviewed to collect information about their safety and health. The associations of physical and psychosocial work conditions with safety and health outcomes, e.g., injuries, illnesses and job satisfaction, are presented. The results of the current study can be utilized in the design of effective accident prevention and OSH training programs for the three age groups and in the regulation of working conditions aboard fishing vessels. PMID:28245578

46 CFR 8.570 - Interim approval of prototype SIP company or vessel plans.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 46 Shipping 1 2010-10-01 2010-10-01 false Interim approval of prototype SIP company or vessel... of prototype SIP company or vessel plans. (a) A company operating under an approved prototype SIP... continue operating under the plans while revisions are developed to bring the prototype SIP company or...

Mission Specific Platforms: Past achievements and future developments in European led ocean research drilling.

NASA Astrophysics Data System (ADS)

Cotterill, Carol; McInroy, David; Stevenson, Alan

2013-04-01

Mission Specific Platform (MSP) expeditions are operated by the European Consortium for Ocean Research Drilling (ECORD). Each MSP expedition is unique within the Integrated Ocean Drilling Program (IODP). In order to complement the abilities of the JOIDES Resolution and the Chikyu, the ECORD Science Operator (ESO) must source vessels and technology suitable for each MSP proposal on a case-by-case basis. The result is that ESO can meet scientific requirements in a flexible manner, whilst maintaining the measurements required for the IODP legacy programme. The process of tendering within EU journals for vessels and technology means that the planning process for each MSP Expedition starts many years in advance of the operational phase. Involvement of proposal proponents from this early stage often leads to the recognition for technological research and development to best meet the scientific aims and objectives. One example of this is the planning for the Atlantis Massif proposal, with collaborative development between the British Geological Survey (BGS) and MARUM, University of Bremen, on suitable instruments for seabed drills, with the European Petrophysics Consortium (EPC) driving the development of suitable wireline logging tools that can be used in association with such seabed systems. Other technological developments being undertaken within the European IODP community include in-situ pressure sampling for gas hydrate expeditions, deep biosphere and fluid sampling equipment and CORK technology. This multi-national collaborative approach is also employed by ESO in the operational phase. IODP Expedition 302 ACEX saw vessel and ice management support from Russia and Sweden to facilitate the first drilling undertaken in Arctic sea ice. A review of MSP expeditions past, present and future reveal the significant impact of European led operations and scientific research within the current IODP programme, and also looking forward to the start of the new International Ocean Discovery Programme in October 2013. Key successes encompass technological development, operational procedures in sensitive areas and research into palaeoclimate and shoreline responses to sea level change amongst others. Increased operational flexibility in the new programme only serves to make the future an exciting one for ocean drilling in Europe.

Development of an oxygen saturation measuring system by using near-infrared spectroscopy

NASA Astrophysics Data System (ADS)

Kono, K.; Nakamachi, E.; Morita, Y.

2017-08-01

Recently, the hypoxia imaging has been recognized as the advanced technique to detect cancers because of a strong relationship with the biological characterization of cancer. In previous studies, hypoxia imaging systems for endoscopic diagnosis have been developed. However, these imaging technologies using the visible light can observe only blood vessels in gastric mucous membrane. Therefore, they could not detect scirrhous gastric cancer which accounts for 10% of all gastric cancers and spreads rapidly into submucous membrane. To overcome this problem, we developed a measuring system of blood oxygen saturation in submucous membrane by using near-infrared (NIR) spectroscopy. NIR, which has high permeability for bio-tissues and high absorbency for hemoglobin, can image and observe blood vessels in submucous membrane. NIR system with LED lights and a CCD camera module was developed to image blood vessels. We measured blood oxygen saturation using the optical density ratio (ODR) of two wavelengths, based on Lambert-Beer law. To image blood vessel clearly and measure blood oxygen saturation accurately, we searched two optimum wavelengths by using a multilayer human gastric-like phantom which has same optical properties as human gastric one. By using Monte Carlo simulation of light propagation, we derived the relationship between the ODR and blood oxygen saturation and elucidated the influence of blood vessel depth on measuring blood oxygen saturation. The oxygen saturation measuring methodology was validated with experiments using our NIR system. Finally, it was confirmed that our system can detect oxygen saturation in various depth blood vessels accurately.

Epithelial-to-endothelial transition and cancer stem cells: two cornerstones of vasculogenic mimicry in malignant tumors.

PubMed

Sun, Baocun; Zhang, Danfang; Zhao, Nan; Zhao, Xiulan

2017-05-02

Vasculogenic mimicry (VM) is a functional microcirculation pattern in malignant tumors accompanied by endothelium-dependent vessels and mosaic vessels. VM has been identified in more than 15 solid tumor types and is associated with poor differentiation, late clinical stage and poor prognosis. Classic anti-angiogenic agents do not target endothelium-dependent vessels and are not efficacious against tumors exhibiting VM. Further insight into the molecular signaling that triggers and promotes VM formation could improve anti-angiogenic therapeutics. Recent studies have shown that cancer stem cells (CSCs) and epithelium-to-endothelium transition (EET), a subtype of epithelial-to-mesenchymal transition (EMT), accelerate VM formation by stimulating tumor cell plasticity, remodeling the extracellular matrix (ECM) and connecting VM channels with host blood vessels. VM channel-lining cells originate from CSCs due to expression of EMT inducers such as Twist1, which promote EET and ECM remodeling. Hypoxia and high interstitial fluid pressure in the tumor microenvironment induce a specific type of cell death, linearly patterned programmed cell necrosis (LPPCN), which spatially guides VM and endothelium-dependent vessel networks. This review focuses on the roles of CSCs and EET in VM, and on possible novel anti-angiogenic strategies against alternative tumor vascularization.

What is precise pathophysiology in development of hypertension in pregnancy? Precision medicine requires precise physiology and pathophysiology.

PubMed

Gao, Qinqin; Tang, Jiaqi; Li, Na; Liu, Bailin; Zhang, Mengshu; Sun, Miao; Xu, Zhice

2018-02-01

It is widely accepted that placental ischemia is central in the evolution of hypertension in pregnancy. Many studies and reviews have targeted placental ischemia to explain mechanisms for initiating pregnancy hypertension. The placenta is rich in blood vessels, which are the basis for developing placental ischemia. However, is the physiology of placental vessels the same as that of nonplacental vessels? What is the pathophysiology of placental vessels in development of pregnancy hypertension? This review aims to provide a comprehensive summary of special features of placental vascular regulations and the pathophysiological changes linked to preeclamptic conditions. Interestingly, some popular theories or accepted concepts could be based on our limited knowledge and evidence regarding placental vascular physiology, pharmacology and pathophysiology. New views raised could offer interesting ideas for future investigation of mechanisms as well as targets for pregnancy hypertension. Copyright © 2017 Elsevier Ltd. All rights reserved.

A scaling law for the local CHF on the external bottom side of a fully submerged reactor vessel

DOE Office of Scientific and Technical Information (OSTI.GOV)

Cheung, F.B.; Haddad, K.H.; Liu, Y.C.

1997-02-01

A scaling law for estimating the local critical heat flux on the outer surface of a heated hemispherical vessel that is fully submerged in water has been developed from the results of an advanced hydrodynamic CHF model for pool boiling on a downward facing curved heating surface. The scaling law accounts for the effects of the size of the vessel, the level of liquid subcooling, the intrinsic properties of the fluid, and the spatial variation of the local critical heat flux along the heating surface. It is found that for vessels with diameters considerably larger than the characteristic size ofmore » the vapor masses, the size effect on the local critical heat flux is limited almost entirely to the effect of subcooling associated with the local liquid head. When the subcooling effect is accounted for separately, the local CHF limit is nearly independent of the vessel size. Based upon the scaling law developed in this work, it is possible to merge, within the experimental uncertainties, all the available local CHF data obtained for various vessel sizes under both saturated and subcooled boiling conditions into a single curve. Applications of the scaling law to commercial-size vessels have been made for various system pressures and water levels above the heated vessel. Over the range of conditions explored in this study, the local CHF limit is found to increase by a factor of two or more from the bottom center to the upper edge of the vessel. Meanwhile, the critical heat flux at a given angular position of the heated vessel is also found to increase appreciably with the system pressure and the water level.« less

Impact of fuel quality regulation and speed reductions on shipping emissions: implications for climate and air quality.

PubMed

Lack, Daniel A; Cappa, Christopher D; Langridge, Justin; Bahreini, Roya; Buffaloe, Gina; Brock, Charles; Cerully, Kate; Coffman, Derek; Hayden, Katherine; Holloway, John; Lerner, Brian; Massoli, Paola; Li, Shao-Meng; McLaren, Robert; Middlebrook, Ann M; Moore, Richard; Nenes, Athanasios; Nuaaman, Ibraheem; Onasch, Timothy B; Peischl, Jeff; Perring, Anne; Quinn, Patricia K; Ryerson, Tom; Schwartz, Joshua P; Spackman, Ryan; Wofsy, Steven C; Worsnop, Doug; Xiang, Bin; Williams, Eric

2011-10-15

Atmospheric emissions of gas and particulate matter from a large ocean-going container vessel were sampled as it slowed and switched from high-sulfur to low-sulfur fuel as it transited into regulated coastal waters of California. Reduction in emission factors (EFs) of sulfur dioxide (SO₂), particulate matter, particulate sulfate and cloud condensation nuclei were substantial (≥ 90%). EFs for particulate organic matter decreased by 70%. Black carbon (BC) EFs were reduced by 41%. When the measured emission reductions, brought about by compliance with the California fuel quality regulation and participation in the vessel speed reduction (VSR) program, are placed in a broader context, warming from reductions in the indirect effect of SO₄ would dominate any radiative changes due to the emissions changes. Within regulated waters absolute emission reductions exceed 88% for almost all measured gas and particle phase species. The analysis presented provides direct estimations of the emissions reductions that can be realized by California fuel quality regulation and VSR program, in addition to providing new information relevant to potential health and climate impact of reduced fuel sulfur content, fuel quality and vessel speed reductions.

Glass Fiber Reinforced Metal Pressure Vessel Design Guide

NASA Technical Reports Server (NTRS)

Landes, R. E.

1972-01-01

The Engineering Guide presents curves and general equations for safelife design of lightweight glass fiber reinforced (GFR) metal pressure vessels operating under anticipated Space Shuttle service conditions. The high composite vessel weight efficiency is shown to be relatively insensitive to shape, providing increased flexibility to designers establishing spacecraft configurations. Spheres, oblate speroids, and cylinders constructed of GFR Inconel X-750, 2219-T62 aluminum, and cryoformed 301 stainless steel are covered; design parameters and performance efficiencies for each configuration are compared at ambient and cryogenic temperature for an operating pressure range of 690 to 2760 N/sq cm (1000 to 4000 psi). Design variables are presented as a function of metal shell operating to sizing (proof) stress ratios for use with fracture mechanics data generated under a separate task of this program.

Advanced life systems hardware development for future missions

NASA Technical Reports Server (NTRS)

1975-01-01

An examination of the pulse formation in an externalized vessel suggests that the vessel does not behave as a simple visco-elastic tube. Pressure-pulse waveform transducers are sensitive either to the pressure present at the vessel wall or to the volume of blood filling a region of tissue. Results of comparisons between intra-and extra-vascular pressure recordings suggest that changes in vasomotor tone and transducer-vessel pressures may be the greatest contributors to the divergence of extra-vascular waveforms from intra-vascular waveforms.

Fine-grained visual marine vessel classification for coastal surveillance and defense applications

NASA Astrophysics Data System (ADS)

Solmaz, Berkan; Gundogdu, Erhan; Karaman, Kaan; Yücesoy, Veysel; Koç, Aykut

2017-10-01

The need for capabilities of automated visual content analysis has substantially increased due to presence of large number of images captured by surveillance cameras. With a focus on development of practical methods for extracting effective visual data representations, deep neural network based representations have received great attention due to their success in visual categorization of generic images. For fine-grained image categorization, a closely related yet a more challenging research problem compared to generic image categorization due to high visual similarities within subgroups, diverse applications were developed such as classifying images of vehicles, birds, food and plants. Here, we propose the use of deep neural network based representations for categorizing and identifying marine vessels for defense and security applications. First, we gather a large number of marine vessel images via online sources grouping them into four coarse categories; naval, civil, commercial and service vessels. Next, we subgroup naval vessels into fine categories such as corvettes, frigates and submarines. For distinguishing images, we extract state-of-the-art deep visual representations and train support-vector-machines. Furthermore, we fine tune deep representations for marine vessel images. Experiments address two scenarios, classification and verification of naval marine vessels. Classification experiment aims coarse categorization, as well as learning models of fine categories. Verification experiment embroils identification of specific naval vessels by revealing if a pair of images belongs to identical marine vessels by the help of learnt deep representations. Obtaining promising performance, we believe these presented capabilities would be essential components of future coastal and on-board surveillance systems.

77 FR 75970 - Submission for OMB Review; Comment Request

Federal Register 2010, 2011, 2012, 2013, 2014

2012-12-26

... reducing an agreement vessel's basis for depreciation by the amount withdrawn from the fund for its... requirements established in program regulations and properly accounting for fund activity on their Federal...

Changes in cross-sectional area of pulmonary vessels on chest computed tomography after chemotherapy in patients with advanced non-squamous non-small-cell lung cancer.

PubMed

Karayama, Masato; Inui, Naoki; Kusagaya, Hideki; Suzuki, Seiichiro; Inoue, Yusuke; Enomoto, Noriyuki; Fujisawa, Tomoyuki; Nakamura, Yutaro; Suda, Takafumi

2016-05-01

Chemotherapy is associated with a risk of vascular damage. Novel anti-angiogenic agents, which can directly affect tumor angiogenesis, are increasingly being used. However, the effects of these agents on normal vasculature are not well understood. Here, we evaluated the effects of chemotherapy in general, and the anti-angiogenic agent bevacizumab, more specifically, on the pulmonary vasculature in patients with advanced non-squamous non-small-cell lung cancer (NSCLC). For this, we used the cross-sectional area of pulmonary vessels (CSA), which is an easily measurable indicator of small pulmonary vasculature on non-contrast chest computed tomography (CT). We retrospectively reviewed CT scans of the lungs of 75 chemo-naïve patients with advanced non-squamous NSCLC, for measurement of CSA, before and after first-line platinum-based chemotherapy, using a semi-automatic image-processing program. Measured vessels were classified in two groups: small vessels with CSA <5 mm(2) and large vessels with CSA between 5 and 10 mm(2). The CSAs for each group of vessels were calculated and summed separately, and expressed as a percentage of the total lung area (%CSA<5 and %CSA5-10). Chemotherapy was associated with a selective decrease in small-diameter vessels, with a significant decrease in %CSA<5, but not %CSA5-10. When comparing chemotherapy with bevacizumab (n = 38) and without bevacizumab (n = 37), there was no significant difference in the reduction of %CSA<5. Platinum-based chemotherapy might induce small pulmonary vascular damage. Use of bevacizumab does not enhance the reduction in area of pulmonary vessels.

Feasibility of potable water generators to meet vessel numeric ballast water discharge limits.

PubMed

Albert, Ryan J; Viveiros, Edward; Falatko, Debra S; Tamburri, Mario N

2017-07-15

Ballast water is taken on-board vessels into ballast water tanks to maintain vessel draft, buoyancy, and stability. Unmanaged ballast water contains aquatic organisms that, when transported and discharged to non-native waters, may establish as invasive species. Technologies capable of achieving regulatory limits designed to decrease the likelihood of invasion include onboard ballast water management systems. However, to date, the treatment development and manufacturing marketplace is limited to large vessels with substantial ballast requirements. For smaller vessels or vessels with reduced ballast requirements, we evaluated the feasibility of meeting the discharge limits by generating ballast water using onboard potable water generators. Case studies and parametric analyses demonstrated the architectural feasibility of installing potable water generators onboard actual vessels with minimal impacts for most vessel types evaluated. Furthermore, land-based testing of a potable water generator demonstrated capability to meet current numeric discharge limits for living organisms in all size classes. Published by Elsevier Ltd.

The National Transonic Facility

NASA Technical Reports Server (NTRS)

Holmes, H. K.

1986-01-01

The National Transonic Facility, NTF, is a high Reynolds Number facility where the increase in Reynolds Number is obtained by operating at high pressures and low temperatures. Liquid nitrogen is allowed to vaporize, making gaseous nitrogen the test medium with temperatures extending down to approximately 100 degrees Kelvin. These factors have created unique, new challenges to those developing sensors and instrumentation. Pressure vessels, thermal enclosures or elaborate temperature compensations schemes, are needed for environmental protection and special materials are needed for sensors and model fabrication. The need for a new measurement, model deformation, was also created. An extensive program to develop the unique sensors and instrumentation was initiated. The data acquisition system and systems to measure aerodynamic forces and pressures, model attitude, and model deformation, are discussed.

Acceptance criteria for welds in ASTM A106 grade B steel pipe and plate

NASA Technical Reports Server (NTRS)

Hudson, C. M.; Wright, D. B., Jr.; Leis, B. N.

1986-01-01

Based on the RECERT Program findings, NASA-Langley funded a fatigue study of code-unacceptable welds. Usage curves were developed which were based on the structural integrity of the welds. The details of this study are presented in NASA CR-178114. The information presented is a condensation and reinterpretation of the information in NASA CR-178114. This condensation and reinterpretation generated usage curves for welds having: (1) indications 0.20 -inch deep by 0.40-inch long, and (2) indications 0.195-inch deep by 8.4-inches long. These curves were developed using the procedures used in formulating the design curves in Section VIII, Division 2 of the American Society of Mechanical Engineers Boiler and Pressure Vessel Code.

Simulant Basis for the Standard High Solids Vessel Design

DOE Office of Scientific and Technical Information (OSTI.GOV)

Peterson, Reid A.; Fiskum, Sandra K.; Suffield, Sarah R.

The Waste Treatment and Immobilization Plant (WTP) is working to develop a Standard High Solids Vessel Design (SHSVD) process vessel. To support testing of this new design, WTP engineering staff requested that a Newtonian simulant and a non-Newtonian simulant be developed that would represent the Most Adverse Design Conditions (in development) with respect to mixing performance as specified by WTP. The majority of the simulant requirements are specified in 24590-PTF-RPT-PE-16-001, Rev. 0. The first step in this process is to develop the basis for these simulants. This document describes the basis for the properties of these two simulant types. Themore » simulant recipes that meet this basis will be provided in a subsequent document.« less

The Environmental Evaluation Work Group Fiscal Year 1979 Studies of the Winter Navigation Demonstration Program. Effects of Ship-Induced Waves in an Ice Environment on the St. Marys River Ecosystem

DTIC Science & Technology

1979-07-27

April 17-21, immediately after the solid ice cover had been broken up by heavy vessel traffic. 4. 1acroinvertebrates of 56 taxa were identified in 75...clams), Amphipoda (scuds), Polychaeta, Ephemeroptera (mayflies), and Trichoptera (caddisflies) were common in all samples and collectively made up about...period of solid ice cover. Comparison of drift net catches in March when there was solid ice cover and moderate vessel traffic with catches in April

Effect of forward speed on the roll damping of three small fishing vessels

DOE Office of Scientific and Technical Information (OSTI.GOV)

Haddara, M.R.; Zhang, S.

1994-05-01

An extensive experimental program has been carried out to estimate roll damping parameters for three models of fishing vessels having different hull shapes and moving with forward speed. Roll damping parameters are determined using a novel method. This method combines the energy method and the modulating function method. The effect of forward speed, initial heel angle and the natural frequency on damping is discussed. A modification of Ikeda's formula for lift damping prediction is suggested. The modified formula produces results which are in good agreement with the experiments.

Nickel-hydrogen CPV battery update

NASA Technical Reports Server (NTRS)

Jones, Kenneth R.; Zagrodnik, Jeffrey P.

1993-01-01

The multicell common pressure vessel (CPV) nickel hydrogen battery manufactured by Johnson Controls Battery Group, Inc. has completed full flight qualification, including random vibration at 19.5 g for two minutes in each axis, electrical characterization in a thermal vacuum chamber, and mass-spectroscopy vessel leak detection. A first launch is scheduled for late in 1992 or early 1993 by the Naval Research Laboratory (NRL). Specifics of the launch date are not available at this time due to the classified nature of the program. Release of orbital data for the battery is anticipated following the launch.

Open Vessel Data Management (OpenVDM) - Open-source Middleware to Assist Vessel Operators Produce Consistent Cruise Data Packages for Archival and Monitor Data Quality.

NASA Astrophysics Data System (ADS)

Pinner, J. W., IV

2016-02-01

Data from shipboard oceanographic sensors come in various formats and collection typically requires multiple data acquisition software packages running on multiple workstations throughout the vessel. Technicians must then corral all or a subset of the resulting data files so that they may be used by shipboard scientists. On many vessels the process of corralling files into a single cruise data package may change from cruise to cruise or even from technician to technician. It is these inconsistencies in the final cruise data packages that pose the greatest challenge when attempting to automate the process of cataloging cruise data for submission to data archives. A second challenge with the management of shipboard data is ensuring it's quality. Problems with sensors may go unnoticed simply because the technician/scientist was unaware the data from a sensor was absent, invalid, or out of range. The Open Vessel Data Management project (OpenVDM) is a ship-wide data management solution developed to address these issues. In the past three years OpenVDM has successfully demonstrated it's ability to adapt to the needs of vessels with different capabilities/missions while delivering a consistent cruise data package to scientists and adhering to the recommendations and best practices set forth by 3rd party data management groups such as R2R. In the last year OpenVDM has implemented a plugin architecture for monitoring data quality. This allowed vessel operators to develop custom data quality tests tailored to their vessel's unique raw datasets. Data quality test are performed in near-real-time and the results are readily available within a web-interface. This plugin architecture allows 3rd party data quality workgroups like SAMOS to migrate their data quality tests to the vessel and provide immediate determination of data quality. OpenVDM is currently operating aboard three vessels. The R/V Endeavor, operated by the University of Rhode Island, is a regional-class UNOLS research vessel operating under the traditional NFS, P.I. driven model. The E/V Nautilus, operated by the Ocean Exploration Trust specializes in ROV-based, telepresence-enabled oceanographic research. The R/V Falkor operated by the Schmidt Ocean Institute is an ocean research platform focusing on cutting-edge technology development.

Teacher at Sea.

ERIC Educational Resources Information Center

Beighley, Karl

1998-01-01

Outlines the experiences of a teacher in the National Oceanic and Atmospheric Administration's (NOAA) Teacher At Sea Program in which teachers are placed on NOAA vessels to work with professional scientists doing critical, real world research. (DDR)

Improved animal models for testing gene therapy for atherosclerosis.

PubMed

Du, Liang; Zhang, Jingwan; De Meyer, Guido R Y; Flynn, Rowan; Dichek, David A

2014-04-01

Gene therapy delivered to the blood vessel wall could augment current therapies for atherosclerosis, including systemic drug therapy and stenting. However, identification of clinically useful vectors and effective therapeutic transgenes remains at the preclinical stage. Identification of effective vectors and transgenes would be accelerated by availability of animal models that allow practical and expeditious testing of vessel-wall-directed gene therapy. Such models would include humanlike lesions that develop rapidly in vessels that are amenable to efficient gene delivery. Moreover, because human atherosclerosis develops in normal vessels, gene therapy that prevents atherosclerosis is most logically tested in relatively normal arteries. Similarly, gene therapy that causes atherosclerosis regression requires gene delivery to an existing lesion. Here we report development of three new rabbit models for testing vessel-wall-directed gene therapy that either prevents or reverses atherosclerosis. Carotid artery intimal lesions in these new models develop within 2-7 months after initiation of a high-fat diet and are 20-80 times larger than lesions in a model we described previously. Individual models allow generation of lesions that are relatively rich in either macrophages or smooth muscle cells, permitting testing of gene therapy strategies targeted at either cell type. Two of the models include gene delivery to essentially normal arteries and will be useful for identifying strategies that prevent lesion development. The third model generates lesions rapidly in vector-naïve animals and can be used for testing gene therapy that promotes lesion regression. These models are optimized for testing helper-dependent adenovirus (HDAd)-mediated gene therapy; however, they could be easily adapted for testing of other vectors or of different types of molecular therapies, delivered directly to the blood vessel wall. Our data also supports the promise of HDAd to deliver long-term therapy from vascular endothelium without accelerating atherosclerotic disease.

The use of the SRIM code for calculation of radiation damage induced by neutrons

NASA Astrophysics Data System (ADS)

Mohammadi, A.; Hamidi, S.; Asadabad, Mohsen Asadi

2017-12-01

Materials subjected to neutron irradiation will being evolve to structural changes by the displacement cascades initiated by nuclear reaction. This study discusses a methodology to compute primary knock-on atoms or PKAs information that lead to radiation damage. A program AMTRACK has been developed for assessing of the PKAs information. This software determines the specifications of recoil atoms (using PTRAC card of MCNPX code) and also the kinematics of interactions. The deterministic method was used for verification of the results of (MCNPX+AMTRACK). The SRIM (formely TRIM) code is capable to compute neutron radiation damage. The PKAs information was extracted by AMTRACK program, which can be used as an input of SRIM codes for systematic analysis of primary radiation damage. Then the Bushehr Nuclear Power Plant (BNPP) radiation damage on reactor pressure vessel is calculated.

The Effect of Cold Work on Properties of Alloy 617

DOE Office of Scientific and Technical Information (OSTI.GOV)

Wright, Richard

2014-08-01

Alloy 617 is approved for non-nuclear construction in the ASME Boiler and Pressure Vessel Code Section I and Section VIII, but is not currently qualified for nuclear use in ASME Code Section III. A draft Code Case was submitted in 1992 to qualify the alloy for nuclear service but efforts were stopped before the approval process was completed.1 Renewed interest in high temperature nuclear reactors has resulted in a new effort to qualify Alloy 617 for use in nuclear pressure vessels. The mechanical and physical properties of Alloy 617 were extensively characterized for the VHTR programs in the 1980’s andmore » incorporated into the 1992 draft Code Case. Recently, the properties of modern heats of the alloy that incorporate an additional processing step, electro-slag re-melting, have been characterized both to confirm that the properties of contemporary material are consistent with those in the historical record and to increase the available database. A number of potential issues that were identified as requiring further consideration prior to the withdrawal of the 1992 Code Case are also being re-examined in the current R&D program. Code Cases are again being developed to allow use of Alloy 617 for nuclear design within the rules of the ASME Boiler and Pressure Vessel Code. In general the Code defines two temperature ranges for nuclear design with austenitic and nickel based alloys. Below 427°C (800°F) time dependent behavior is not considered, while above this temperature creep and creep-fatigue are considered to be the dominant life-limiting deformation modes. There is a corresponding differentiation in the treatment of the potential for effects associated with cold work. Below 427°C the principal issue is the relationship between the level of cold work and the propensity for stress corrosion cracking and above that temperature the primary concern is the impact of cold work on creep-rupture behavior.« less

Income diversification and risk for fishermen.

PubMed

Kasperski, Stephen; Holland, Daniel S

2013-02-05

Catches and prices from many fisheries exhibit high interannual variability, leading to variability in the income derived by fishery participants. The economic risk posed by this may be mitigated in some cases if individuals participate in several different fisheries, particularly if revenues from those fisheries are uncorrelated or vary asynchronously. We construct indices of gross income diversification from fisheries at the level of individual vessels and find that the income of the current fleet of vessels on the US West Coast and in Alaska is less diverse than at any point in the past 30 y. We also find a dome-shaped relationship between the variability of individuals' income and income diversification, which implies that a small amount of diversification does not reduce income risk but that higher levels of diversification can substantially reduce the variability of income from fishing. Moving from a single fishery strategy to a 50-25-25 split in revenues reduces the expected coefficient of variation of gross revenues between 24% and 65% for the vessels included in this study. The increasing access restrictions in many marine fisheries through license reductions and moratoriums have the potential to limit fishermen's ability to diversify their income risk across multiple fisheries. Catch share programs often result in consolidation initially and may reduce diversification. However, catch share programs also make it feasible for fishermen to build a portfolio of harvest privileges and potentially reduce their income risk. Therefore, catch share programs create both threats and opportunities for fishermen wishing to maintain diversified fishing strategies.

Income diversification and risk for fishermen

PubMed Central

Kasperski, Stephen; Holland, Daniel S.

2013-01-01

Catches and prices from many fisheries exhibit high interannual variability, leading to variability in the income derived by fishery participants. The economic risk posed by this may be mitigated in some cases if individuals participate in several different fisheries, particularly if revenues from those fisheries are uncorrelated or vary asynchronously. We construct indices of gross income diversification from fisheries at the level of individual vessels and find that the income of the current fleet of vessels on the US West Coast and in Alaska is less diverse than at any point in the past 30 y. We also find a dome-shaped relationship between the variability of individuals' income and income diversification, which implies that a small amount of diversification does not reduce income risk but that higher levels of diversification can substantially reduce the variability of income from fishing. Moving from a single fishery strategy to a 50-25-25 split in revenues reduces the expected coefficient of variation of gross revenues between 24% and 65% for the vessels included in this study. The increasing access restrictions in many marine fisheries through license reductions and moratoriums have the potential to limit fishermen's ability to diversify their income risk across multiple fisheries. Catch share programs often result in consolidation initially and may reduce diversification. However, catch share programs also make it feasible for fishermen to build a portfolio of harvest privileges and potentially reduce their income risk. Therefore, catch share programs create both threats and opportunities for fishermen wishing to maintain diversified fishing strategies. PMID:23341621

Loss of unc45a precipitates arteriovenous shunting in the aortic arches

PubMed Central

Anderson, Matthew J.; Pham, Van N.; Vogel, Andreas M.; Weinstein, Brant M.; Roman, Beth L.

2008-01-01

Aortic arch malformations are common congenital disorders that are frequently of unknown etiology. To gain insight into the factors that guide branchial aortic arch development, we examined the process by which these vessels assemble in wild type zebrafish embryos and in kurzschlusstr12 (kus tr12) mutants. In wild type embryos, each branchial aortic arch first appears as an island of angioblasts in the lateral pharyngeal mesoderm, then elaborates by angiogenesis to connect to the lateral dorsal aorta and ventral aorta. In kustr12 mutants, angioblast formation and initial sprouting are normal, but aortic arches 5 and 6 fail to form a lumenized connection to the lateral dorsal aorta. Blood enters these blind-ending vessels from the ventral aorta, distending the arteries and precipitating fusion with an adjacent vein. This arteriovenous malformation (AVM), which shunts nearly all blood directly back to the heart, is not genetically programmed, as its formation correlates with blood flow and aortic arch enlargement. By positional cloning, we have identified a nonsense mutation in unc45a in kustr12 mutants. Our results are the first to ascribe a role for Unc45a, a putative myosin chaperone, in vertebrate development, and identify a novel mechanism by which an AVM can form. PMID:18462713

DOE Office of Scientific and Technical Information (OSTI.GOV)

Reiersen, W.; Heitzenroeder, P.; Neilson, G. H.

The National Compact Stellarator Experiment (NCSX) is being constructed at the Princeton Plasma Physics Laboratory (PPPL) in partnership with the Oak Ridge National Laboratory (ORNL). The stellarator core is designed to produce a compact 3-D plasma that combines stellarator and tokamak physics advantages. The engineering challenges of NCSX stem from its complex geometry. From the project's start in April, 2003 to September, 2004, the fabrication specifications for the project's two long-lead components, the modular coil winding forms and the vacuum vessel, were developed. An industrial manufacturing R&D program refined the processes for their fabrication as well as production cost andmore » schedule estimates. The project passed a series of reviews and established its performance baseline with the Department of Energy. In September 2004, fabrication was approved and contracts for these components were awarded. The suppliers have completed the engineering and tooling preparations and are in production. Meanwhile, the project completed preparations for winding the coils at PPPL by installing a coil manufacturing facility and developing all necessary processes through R&D. The main activities for the next two years will be component manufacture, coil winding, and sub-assembly of the vacuum vessel and coil subsets. Machine sector sub-assembly, machine assembly, and testing will follow, leading to First Plasma in July 2009.« less

An Acoustic Emission and Acousto-Ultrasonic Analysis of Impact Damaged Composite Pressure Vessels

NASA Technical Reports Server (NTRS)

Walker, James L.; Workman, Gary L.; Workman, Gary L.

1996-01-01

The research presented herein summarizes the development of acoustic emission (AE) and acousto-ultrasonic (AU) techniques for the nondestructive evaluation of filament wound composite pressure vessels. Vessels fabricated from both graphite and kevlar fibers with an epoxy matrix were examined prior to hydroburst using AU and during hydroburst using AE. A dead weight drop apparatus featuring both blunt and sharp impactor tips was utilized to produce a single known energy 'damage' level in each of the vessels so that the degree to which the effects of impact damage could be measured. The damage levels ranged from barely visible to obvious fiber breakage and delamination. Independent neural network burst pressure prediction models were developed from a sample of each fiber/resin material system. Here, the cumulative AE amplitude distribution data collected from low level proof test (25% of the expected burst for undamaged vessels) were used to measure the effects of the impact on the residual burst pressure of the vessels. The results of the AE/neural network model for the inert propellant filled graphite/epoxy vessels 'IM7/3501-6, IM7/977-2 and IM7/8553-45' demonstrated that burst pressures can be predicted from low level AE proof test data, yielding an average error of 5.0%. The trained network for the IM7/977-2 class vessels was also able to predict the expected burst pressure of taller vessels (three times longer hoop region length) constructed of the same material and using the same manufacturing technique, with an average error of 4.9%. To a lesser extent, the burst pressure prediction models could also measure the effects of impact damage to the kevlar/epoxy 'Kevlar 49/ DPL862' vessels. Here though, due to the higher attenuation of the material, an insufficient amount of AE amplitude information was collected to generate robust network models. Although, the worst case trial errors were less than 6%, when additional blind predictions were attempted, errors as high as 50% were produced. An acousto-ultrasonic robotic evaluation system (AURES) was developed for mapping the effects of damage on filament wound pressure vessels prior to hydroproof testing. The AURES injects a single broadband ultrasonic pulse into each vessel at preprogrammed positions and records the effects of the interaction of that pulse on the material volume with a broadband receiver. A stress wave factor in the form of the energy associated with the 750 to 1000 kHz and 1000 to 1250 kHz frequency bands were used to map the potential failure sites for each vessel. The energy map associated with the graphite/epoxy vessels was found to decrease in the region of the impact damage. The kevlar vessels showed the opposite trend, with the energy values increasing around the damage/failure sites.

Collagen VI Ablation Retards Brain Tumor Progression Due to Deficits in Assembly of the Vascular Basal Lamina

PubMed Central

You, Weon-Kyoo; Bonaldo, Paolo; Stallcup, William B.

2012-01-01

To investigate the importance of the vascular basal lamina in tumor blood vessel morphogenesis and function, we compared vessel development, vessel function, and progression of B16F10 melanoma tumors in the brains of wild-type and collagen VI-null mice. In 7-day tumors in the absence of collagen VI, the width of the vascular basal lamina was reduced twofold. Although the ablation of collagen VI did not alter the abundance of blood vessels, a detailed analysis of the number of either pericytes or endothelial cells (or pericyte coverage of endothelial cells) showed that collagen VI-dependent defects during the assembly of the basal lamina have negative effects on both pericyte maturation and the sprouting and survival of endothelial cells. As a result of these deficits, vessel patency was reduced by 25%, and vessel leakiness was increased threefold, resulting in a 10-fold increase in tumor hypoxia along with a fourfold increase in hypoxia-inducible factor-1α expression. In 12-day collagen VI-null tumors, vascular endothelial growth factor expression was increased throughout the tumor stroma, in contrast to the predominantly vascular pattern of vascular endothelial growth factor expression in wild-type tumors. Vessel size was correspondingly reduced in 12-day collagen VI-null tumors. Overall, these vascular deficits produced a twofold decrease in tumor volume in collagen VI-null mice, confirming that collagen VI-dependent basal lamina assembly is a critical aspect of vessel development. PMID:22200614

Highly efficient nonrigid motion‐corrected 3D whole‐heart coronary vessel wall imaging

PubMed Central

Atkinson, David; Henningsson, Markus; Botnar, Rene M.; Prieto, Claudia

2016-01-01

Purpose To develop a respiratory motion correction framework to accelerate free‐breathing three‐dimensional (3D) whole‐heart coronary lumen and coronary vessel wall MRI. Methods We developed a 3D flow‐independent approach for vessel wall imaging based on the subtraction of data with and without T2‐preparation prepulses acquired interleaved with image navigators. The proposed method corrects both datasets to the same respiratory position using beat‐to‐beat translation and bin‐to‐bin nonrigid corrections, producing coregistered, motion‐corrected coronary lumen and coronary vessel wall images. The proposed method was studied in 10 healthy subjects and was compared with beat‐to‐beat translational correction (TC) and no motion correction for the left and right coronary arteries. Additionally, the coronary lumen images were compared with a 6‐mm diaphragmatic navigator gated and tracked scan. Results No significant differences (P > 0.01) were found between the proposed method and the gated and tracked scan for coronary lumen, despite an average improvement in scan efficiency to 96% from 59%. Significant differences (P < 0.01) were found in right coronary artery vessel wall thickness, right coronary artery vessel wall sharpness, and vessel wall visual score between the proposed method and TC. Conclusion The feasibility of a highly efficient motion correction framework for simultaneous whole‐heart coronary lumen and vessel wall has been demonstrated. Magn Reson Med 77:1894–1908, 2017. © 2016 International Society for Magnetic Resonance in Medicine PMID:27221073

Coronary artery wall imaging.

PubMed

Keegan, Jennifer

2015-05-01

Like X-Ray contrast angiography, MR coronary angiograms show the vessel lumens rather than the vessels themselves. Consequently, outward remodeling of the vessel wall, which occurs in subclinical coronary disease before luminal narrowing, cannot be seen. The current gold standard for assessing the coronary vessel wall is intravascular ultrasound, and more recently, optical coherence tomography, both of which are invasive and use ionizing radiation. A noninvasive, low-risk technique for assessing the vessel wall would be beneficial to cardiologists interested in the early detection of preclinical disease and for the safe monitoring of the progression or regression of disease in longitudinal studies. In this review article, the current state of the art in MR coronary vessel wall imaging is discussed, together with validation studies and recent developments. © 2014 Wiley Periodicals, Inc.

Chemokine guided angiogenesis directs coronary vasculature formation in zebrafish

PubMed Central

Harrison, Michael R.M.; Bussmann, Jeroen; Huang, Ying; Zhao, Long; Osorio, Arthela; Burns, C. Geoffrey; Burns, Caroline E.; Sucov, Henry M.; Siekmann, Arndt F.; Lien, Ching-Ling

2015-01-01

SUMMARY Interruption of coronary blood supply severely impairs heart function with often-fatal consequences for heart disease patients. However the formation and maturation of these coronary vessels is not fully understood. Here we provide a detailed analysis of coronary vessel development in zebrafish. We observe that coronary vessels form in zebrafish by angiogenic sprouting of arterial cells derived from the endocardium at the atrioventricular canal. Endothelial cells express the CXC-motif chemokine receptor Cxcr4a and migrate to vascularize the ventricle under the guidance of the myocardium-expressed ligand Cxcl12b. cxcr4a mutant zebrafish fail to form a vascular network, whereas ectopic expression of Cxcl12b ligand induces coronary vessel formation. Importantly, cxcr4a mutant zebrafish fail to undergo heart regeneration following injury. Our results suggest that chemokine-signaling has an essential role in coronary vessel formation by directing migration of endocardium-derived endothelial cells. Poorly developed vasculature in cxcr4a mutants likely underlies decreased regenerative potential in adults. PMID:26017769

Vascular development in the vertebrate pancreas.

PubMed

Azizoglu, D Berfin; Chong, Diana C; Villasenor, Alethia; Magenheim, Judith; Barry, David M; Lee, Simon; Marty-Santos, Leilani; Fu, Stephen; Dor, Yuval; Cleaver, Ondine

2016-12-01

The vertebrate pancreas is comprised of a highly branched tubular epithelium, which is intimately associated with an extensive and specialized vasculature. While we know a great deal about basic vascular anatomy of the adult pancreas, as well as islet capillaries, surprisingly little is known about the ontogeny of its blood vessels. Here, we analyze development of the pancreatic vasculature in the mouse embryo. We show that pancreatic epithelial branches intercalate with the fine capillary plexus of the surrounding pancreatic mesenchyme. Endothelial cells (ECs) within this mesenchyme are heterogeneous from the onset of organogenesis. Pancreatic arteries take shape before veins, in a manner analogous to early embryonic vessels. The main central artery forms during mid-gestation, as a result of vessel coalescence and remodeling of a vascular plexus. In addition, we show that vessels in the forming pancreas display a predictable architecture that is dependent on VEGF signaling. Over-expression of VEGF disrupts vascular patterning and arteriovenous differentiation within the developing pancreas. This study constitutes a first-time in-depth cellular and molecular characterization of pancreatic blood vessels, as they coordinately grow along with the pancreatic epithelium. Copyright © 2016 Elsevier Inc. All rights reserved.

Fusion materials semiannual progress report for the period ending December 31, 1996

DOE Office of Scientific and Technical Information (OSTI.GOV)

NONE

1997-04-01

This is the twenty-first in a series of semiannual technical progress reports on fusion materials. This report combines the full spectrum of research and development activities on both metallic and non-metallic materials with primary emphasis on the effects of the neutronic and chemical environment on the properties and performance of materials for in-vessel components. This effort forms one element of the materials program being conducted in support of the Fusion Energy Sciences Program of the US Department of Energy. The other major element of the program is concerned with the interactions between reactor materials and the plasma and is reportedmore » separately. The report covers the following topics: vanadium alloys; silicon carbide composite materials; ferritic/martensitic steels; copper alloys and high heat flux materials; austenitic stainless steels; insulating ceramics and optical materials; solid breeding materials; radiation effects, mechanistic studies and experimental methods; dosimetry, damage parameters, and activation calculations; materials engineering and design requirements; and irradiation facilities, test matrices, and experimental methods.« less

TRAC-P1: an advanced best estimate computer program for PWR LOCA analysis. I. Methods, models, user information, and programming details

DOE Office of Scientific and Technical Information (OSTI.GOV)

Not Available

1978-05-01

The Transient Reactor Analysis Code (TRAC) is being developed at the Los Alamos Scientific Laboratory (LASL) to provide an advanced ''best estimate'' predictive capability for the analysis of postulated accidents in light water reactors (LWRs). TRAC-Pl provides this analysis capability for pressurized water reactors (PWRs) and for a wide variety of thermal-hydraulic experimental facilities. It features a three-dimensional treatment of the pressure vessel and associated internals; two-phase nonequilibrium hydrodynamics models; flow-regime-dependent constitutive equation treatment; reflood tracking capability for both bottom flood and falling film quench fronts; and consistent treatment of entire accident sequences including the generation of consistent initial conditions.more » The TRAC-Pl User's Manual is composed of two separate volumes. Volume I gives a description of the thermal-hydraulic models and numerical solution methods used in the code. Detailed programming and user information is also provided. Volume II presents the results of the developmental verification calculations.« less

The effect of autoimmune retinopathy on retinal vessel oxygen saturation.

PubMed

Waizel, Maria; Türksever, Cengiz; Todorova, Margarita G

2018-05-22

To study the retinal vessel oxygen saturation alterations in patients with autoimmune retinopathy (AIR) and patients with autoimmune retinopathy associated with retinitis pigmentosa (AIR-RP) in comparison with healthy controls and patients with isolated retinitis pigmentosa (RP). Prospective, cross-sectional, and non-interventional study. Retinal vessel oximetry (RO) was performed on a total of 139 eyes: six eyes suffering from AIR and four eyes with AIR-RP were compared to 59 healthy control eyes and to 70 eyes with RP. A computer-based program of the retinal vessel analyser unit (IMEDOS Systems UG, Jena, Germany) was used to evaluate retinal vessel oxygen saturation. The mean oxygen saturation in the first and second branch retinal arterioles (A-SO 2 ) and venules (V-SO 2 ) were measured and their difference (A-V SO 2 ) was calculated. In addition, we measured the diameter of the retinal arterioles (D-A) and venules (D-V). Oxygen metabolism is altered in patients with isolated AIR and AIR-RP. Both, AIR and AIR-RP groups, differed from healthy controls showing significantly higher V-SO 2 values and significantly lower A-V SO 2 values (p < 0.025). In addition, the AIR-RP group could be differentiated from eyes suffering from isolated RP by means of significantly higher V-SO 2 values. Comparing retinal vessel diameters, both, the AIR and AIR-RP groups, presented with significant arterial (p = 0.05) and venular (p < 0.03) vessel attenuation than the healthy control group. Based on our results, in analogy to patients suffering from RP, oxygen metabolism seems to be altered in AIR patients.

Traversing and labeling interconnected vascular tree structures from 3D medical images

NASA Astrophysics Data System (ADS)

O'Dell, Walter G.; Govindarajan, Sindhuja Tirumalai; Salgia, Ankit; Hegde, Satyanarayan; Prabhakaran, Sreekala; Finol, Ender A.; White, R. James

2014-03-01

Purpose: Detailed characterization of pulmonary vascular anatomy has important applications for the diagnosis and management of a variety of vascular diseases. Prior efforts have emphasized using vessel segmentation to gather information on the number or branches, number of bifurcations, and branch length and volume, but accurate traversal of the vessel tree to identify and repair erroneous interconnections between adjacent branches and neighboring tree structures has not been carefully considered. In this study, we endeavor to develop and implement a successful approach to distinguishing and characterizing individual vascular trees from among a complex intermingling of trees. Methods: We developed strategies and parameters in which the algorithm identifies and repairs false branch inter-tree and intra-tree connections to traverse complicated vessel trees. A series of two-dimensional (2D) virtual datasets with a variety of interconnections were constructed for development, testing, and validation. To demonstrate the approach, a series of real 3D computed tomography (CT) lung datasets were obtained, including that of an anthropomorphic chest phantom; an adult human chest CT; a pediatric patient chest CT; and a micro-CT of an excised rat lung preparation. Results: Our method was correct in all 2D virtual test datasets. For each real 3D CT dataset, the resulting simulated vessel tree structures faithfully depicted the vessel tree structures that were originally extracted from the corresponding lung CT scans. Conclusion: We have developed a comprehensive strategy for traversing and labeling interconnected vascular trees and successfully implemented its application to pulmonary vessels observed using 3D CT images of the chest.

The prognostic significance of lymphatics in colorectal liver metastases.

PubMed

Muralidharan, Vijayaragavan; Nguyen, Linh; Banting, Jonathan; Christophi, Christopher

2014-01-01

Background. Colorectal Cancer (CRC) is the most common form of cancer diagnosed in Australia across both genders. Approximately, 40%-60% of patients with CRC develop metastasis, the liver being the most common site. Almost 70% of CRC mortality can be attributed to the development of liver metastasis. This study examines the pattern and density of lymphatics in colorectal liver metastases (CLM) as predictors of survival following hepatic resection for CLM. Methods. Patient tissue samples were obtained from the Victorian Cancer Biobank. Immunohistochemistry was used to examine the spatial differences in blood and lymphatic vessel densities between different regions within the tumor (CLM) and surrounding host tissue. Lymphatic vessel density (LVD) was assessed as a potential prognostic marker. Results. Patients with low lymphatic vessel density in the tumor centre, tumor periphery, and adjacent normal liver demonstrated a significant disease-free survival advantage compared to patients with high lymphatic vessel density (P = 0.01, P > 0.01, and P = 0.05, resp.). Lymphatic vessel density in the tumor centre and periphery and adjacent normal liver was an accurate predictive marker of disease-free survival (P = 0.05). Conclusion. Lymphatic vessel density in CLM appears to be an accurate predictor of recurrence and disease-free survival.

Ultrasonic Doppler measurement of renal artery blood flow

NASA Technical Reports Server (NTRS)

1974-01-01

Implantable pulsed Doppler ultrasonic flowmeter development has resulted in designs for application to the aortas of dogs and humans, and to human renal and coronary arteries. A figure of merit was derived for each design, indicating the degree of its precision. An H-array design for transcutaneous observation of blood flow was developed and tested in vitro. Two other simplified designs for the same purpose obviate the need to determine vessel orientation. One of these will be developed in the next time period. Techniques for intraoperative use and for implantation have had mixed success. While satisfactory on large vessels, higher ultrasonic frequencies and alteration of transducer design are required for satisfactory operation of pulsed Doppler flowmeters with small vessels.

The R/V Folger a Floating Laboratory: Teaching Marine Science Skills on Lake Champlain (Invited)

NASA Astrophysics Data System (ADS)

Manley, P.; Manley, T.

2013-12-01

Undergraduate senior work has been required at Middlebury College as far back as 1960's and hands-on experiential learning was and still is the mode for our geology courses. The history of Middlebury College having a research vessel started in the 1970's when Dave Folger started the marine component of our curriculum and obtained the first Middlebury College's research vessel - a coast guard rescue surf boat (Bruno Schmidt). The second Middlebury College research vessel, the R/V Baldwin was purchased in 1985 and was used exclusively in a river-like setting due to its open cockpit and minimal research equipment. In 1990, Middlebury College received a grant from NSF-MRI to upgrade the vessel, to a then state-of the-art small oceanographic vessel including new equipment (CTD, side-scan sonar, ROV, met station, coring devices, computers and navigation). Middlebury College contributed monies to enclose the wheelhouse, install safer diesel engines, as well as a winch and an A-frame to haul in equipment. Over 600+ students used the Baldwin in a variety of geology courses; mainly Oceanography and Marine Geology. In 2010, Middlebury College received an NSF -ARRA grant (American Recovery and Reinvestment Act) to replace the ailing R/V Baldwin with a floating state-of-the art laboratory with the specific goals of increasing 1) access to lake research for Middlebury faculty and students in the biological, chemical, and environmental sciences, 2) the scope of lake research by reducing transit times over this 100km long lake, 3) stability for broad-lake research, 4) improve and expand research capabilities on Lake Champlain, 5) the carrying capacity (both equipment and people), and 6) instructional capability and overnight capabilities. The newly built R/V Folger is a sophisticated research vessel with advanced capabilities that provides a greater capacity to the research infrastructure on Lake Champlain, enhancing interdisciplinary inquiry not only for Middlebury College, but for other members of the local educational community for the next 30 to 50 years. The R/V Folger hosts significant amount of lab space allowing for on-vessel processing of real time data, enhanced navigational capabilities, smart classroom technology and new instrumentation such as multi-beam and CTD-rosette system. This all aluminum new research vessel, besides providing a new platform for Middlebury College's students, will also be used to enable faculty at other local colleges to provide experiential training in research techniques that would otherwise be unavailable; provide research training to local K-12 teachers; offer outreach to "land-locked" institutions and organizations within our tri-state region (NY, NH and VT); the development of a nautical archaeology program in the Lake Champlain basin; and produce data with environmental benefits to the region.

46 CFR 62.50-20 - Additional requirements for minimally attended machinery plants.

Code of Federal Regulations, 2014 CFR

2014-10-01

...) MARINE ENGINEERING VITAL SYSTEM AUTOMATION Automated Self-propelled Vessel Manning § 62.50-20 Additional... program must be functioning prior to the completion of the evaluation period for reduced manning required...

46 CFR 62.50-20 - Additional requirements for minimally attended machinery plants.

Code of Federal Regulations, 2012 CFR

2012-10-01

...) MARINE ENGINEERING VITAL SYSTEM AUTOMATION Automated Self-propelled Vessel Manning § 62.50-20 Additional... program must be functioning prior to the completion of the evaluation period for reduced manning required...

46 CFR 62.50-20 - Additional requirements for minimally attended machinery plants.

Code of Federal Regulations, 2011 CFR

2011-10-01

...) MARINE ENGINEERING VITAL SYSTEM AUTOMATION Automated Self-propelled Vessel Manning § 62.50-20 Additional... program must be functioning prior to the completion of the evaluation period for reduced manning required...

46 CFR 62.50-20 - Additional requirements for minimally attended machinery plants.

Code of Federal Regulations, 2013 CFR

2013-10-01

...) MARINE ENGINEERING VITAL SYSTEM AUTOMATION Automated Self-propelled Vessel Manning § 62.50-20 Additional... program must be functioning prior to the completion of the evaluation period for reduced manning required...

50 CFR 660.160 - Catcher/processor (C/P) Coop Program.

Code of Federal Regulations, 2013 CFR

2013-10-01

... not be accepted unless it includes all of the required information; the descriptive items listed in... deployment by the completion of the electronic vessel and/or processor survey(s); and (E) Immediately report...

50 CFR 660.160 - Catcher/processor (C/P) Coop Program.

Code of Federal Regulations, 2012 CFR

2012-10-01

... not be accepted unless it includes all of the required information; the descriptive items listed in... deployment by the completion of the electronic vessel and/or processor survey(s); and (E) Immediately report...

50 CFR 660.160 - Catcher/processor (C/P) Coop Program.

Code of Federal Regulations, 2014 CFR

2014-10-01

... not be accepted unless it includes all of the required information; the descriptive items listed in... the completion of the electronic vessel and/or processor survey(s); and (E) Immediately report to the...

50 CFR 660.160 - Catcher/processor (C/P) Coop Program.

Code of Federal Regulations, 2011 CFR

2011-10-01

... information; the descriptive items listed in this paragraph appear to meet the stated purpose; and information... deployment by the completion of the electronic vessel and/or processor survey(s); and (E) Immediately report...

Technical Readiness and Gaps Analysis of Commercial Optical Materials and Measurement Systems for Advanced Small Modular Reactors

DOE Office of Scientific and Technical Information (OSTI.GOV)

Anheier, Norman C.; Suter, Jonathan D.; Qiao, Hong

2013-08-06

This report intends to support Department of Energy’s Office of Nuclear Energy (DOE-NE) Nuclear Energy Research and Development Roadmap and industry stakeholders by evaluating optical-based instrumentation and control (I&C) concepts for advanced small modular reactor (AdvSMR) applications. These advanced designs will require innovative thinking in terms of engineering approaches, materials integration, and I&C concepts to realize their eventual viability and deployability. The primary goals of this report include: 1. Establish preliminary I&C needs, performance requirements, and possible gaps for AdvSMR designs based on best available published design data. 2. Document commercial off-the-shelf (COTS) optical sensors, components, and materials in termsmore » of their technical readiness to support essential AdvSMR in-vessel I&C systems. 3. Identify technology gaps by comparing the in-vessel monitoring requirements and environmental constraints to COTS optical sensor and materials performance specifications. 4. Outline a future research, development, and demonstration (RD&D) program plan that addresses these gaps and develops optical-based I&C systems that enhance the viability of future AdvSMR designs. The development of clean, affordable, safe, and proliferation-resistant nuclear power is a key goal that is documented in the Nuclear Energy Research and Development Roadmap. This roadmap outlines RD&D activities intended to overcome technical, economic, and other barriers, which currently limit advances in nuclear energy. These activities will ensure that nuclear energy remains a viable component to this nation’s energy security.« less