Alternative management and funding options for aeronautics programs, Task 1

NASA Technical Reports Server (NTRS)

1975-01-01

Research and technology will be at lower program levels with basic military research for aviation decreasing as fewer aircraft programs are initiated and the present new aircraft programs move into the prototype and production status. The key question is can industry take on the management and financing role and meet the criteria and characteristics considered essential for a viable research and technology program. The criteria for evaluating alternative approaches include an examination of the nature of the product to be provided, responsiveness to changing needs, efficiency in terms of costs, ability to provide leadership, and to provide impartial and independent evaluation of approaches, and to provide technological inputs for regulating functions.

Clean Cities Plug-In Electric Vehicle Handbook for Fleet Managers

DOE Office of Scientific and Technical Information (OSTI.GOV)

None

2012-04-01

Plug-in electric vehicles (PEVs) are entering the automobile market and are viable alternatives to conventional vehicles. This guide for fleet managers describes the basics of PEV technology, PEV benefits for fleets, how to select the right PEV, charging a PEV, and PEV maintenance.

Furfural Induces Reactive Oxygen Species Accumulation and Cellular Damage in Saccharomyces Cerevisiae

USDA-ARS?s Scientific Manuscript database

Background: Biofuels offer a viable alternative to petroleum-based fuel. However, current methods are not sufficient and technology to use lignocellulosic biomass as a fermentation substrate faces several challenges. One challenge is the need of a robust fermentative microorganism that can tolera...

Web-Based Training. ERIC Digest No. 218.

ERIC Educational Resources Information Center

Brown, Bettina Lankard

Reduced training costs, worldwide accessibility, and improved technological capabilities have made Web-based training (WBT) a viable alternative to classroom instruction. WBT enables businesses to cut their training costs. Efficiency of operation is another major advantage of WBT. The flexibility of time, place, and programs offered via WBT…

Alternatives to flat panel displays in vehicle turrets

NASA Astrophysics Data System (ADS)

Nicholson, Gail

2011-06-01

Space is a premium in vehicle turrets. Reducing the footprint of displays inside turrets frees up space for the warfighter. Traditional military ruggedized flat panel displays cannot reside flush with the curved turret wall and consumes more space than their advertized size. The lack of turret space also makes balancing human factors difficult. To better meet the Warfighter needs, alternatives and incremental upgrades to the flat panel displays in turrets were compiled. Each alternative technology was assessed against the constraints of a turret. Benefits, issues, and predictions to implementation are summarized. Viable alternatives are being developed into suitable options.

Physics First: Impact on SAT Math Scores

ERIC Educational Resources Information Center

Bouma, Craig E.

2013-01-01

Improving science, technology, engineering, and mathematics (STEM) education has become a national priority and the call to modernize secondary science has been heard. A Physics First (PF) program with the curriculum sequence of physics, chemistry, and biology (PCB) driven by inquiry- and project-based learning offers a viable alternative to the…

Fuel cells are a commercially viable alternative for the production of "clean" energy.

PubMed

Niakolas, Dimitris K; Daletou, Maria; Neophytides, Stylianos G; Vayenas, Constantinos G

2016-01-01

Fuel cells present a highly efficient and environmentally friendly alternative technology for decentralized energy production. The scope of the present study is to provide an overview of the technological and commercialization readiness level of fuel cells. Specifically, there is a brief description of their general advantages and weaknesses in correlation with various technological actions and political strategies, which are adopted towards their proper positioning in the global market. Some of the most important key performance indicators are also discussed, alongside with a few examples of broad commercialization. It is concluded that the increasing number of companies which utilize and invest on this technology, in combination with the supply chain improvements and the concomitant technological maturity and recognition, reinforce the fuel cell industry so as to become well-aligned for global success.

Solar Energy in the Home. Revised.

ERIC Educational Resources Information Center

Roeder, Allen A.; Woodland, James A.

Recommended for grades 10-12 physical, earth, or general science classes, this 5-7 day unit is designed to give students a general understanding of solar energy and its use as a viable alternative to present energy sources. Along with this technology, students examine several factors of solar energy which influence the choice of solar home site…

Subcutaneous insulin therapy - end of the road after 80 years?

PubMed

Leifke, E; Strack, T R

2014-02-01

Subcutaneous (SC) insulin therapy has been a mainstay of pharmacological diabetes management from the moment insulin was successfully developed as treatment. Insulin formulations have become more refined and less allergenic over time, and ancillary technologies such as injection devices and glucose measurement tools have evolved to the extent of permitting closed-loop therapy. However, investigations have continued exploring alternative routes of administration with the ultimate goal of implantable islet replacements, whether cell- or "silicon"-based. Progress on these lines of research, however, has been slow to present patients with viable options: alternative delivery routes have failed to deliver insulin reliably and with commercially viable efficiency, while beta cell transplantation continues to struggle with tissue availability and in vivo viability. In the meantime, SC insulin formulations have advanced for rapid- and long-acting formulations, to better meet typical insulin requirements across the day. Thus, SC insulin will likely remain a key technology for the foreseeable future in order to address the needs of an ever larger number of insulin-dependent patients with diabetes. Copyright 2014 Prous Science, S.A.U. or its licensors. All rights reserved.

Solar disinfection of infectious biomedical waste: a new approach for developing countries.

PubMed

Chitnis, V; Chitnis, S; Patil, S; Chitnis, D

2003-10-18

Poor developing countries cannot afford expensive technologies such as incineration for management of infectious biomedical waste. We assessed solar heating as an alternative technology. We immersed simulated infectious waste with added challenge bacteria in water in a box-type solar cooker, which was left in the sun for 6 h. In 24 sets of observations, the amount of viable bacteria was reduced by about 7 log. We also tested infectious medical waste with a heavy load of bacteria (10(8)-10(9)/g) from our hospital's burn unit for solar heat disinfection in 20 experiments. Our results showed a similar 7 log reduction in the amount of viable bacteria. Solar heating thus seems to be a cheap method to disinfect infectious medical waste in less economically developed countries.

Alternatives for NASTRAN maintenance, modification and dissemination

NASA Technical Reports Server (NTRS)

Schaeffer, H. G.

1977-01-01

Various alternatives to direct NASA support of the program are considered ranging from no support at one end of the spectrum to subsidizing a non profit user's group at the other. Of all the alternatives that are developed, the user group appears to be most viable. NASA's past and future roles in the development of computerized technology are also considered. The need for an institute for computational analysis is identified and NASA's possible involvement is described. The goals of the proposed institute and research funds to support an activity that has the potential of a much larger impact on the technical community are identified.

Prioritization Methodology for Chemical Replacement

NASA Technical Reports Server (NTRS)

Cruit, W.; Schutzenhofer, S.; Goldberg, B.; Everhart, K.

1993-01-01

This project serves to define an appropriate methodology for effective prioritization of efforts required to develop replacement technologies mandated by imposed and forecast legislation. The methodology used is a semiquantitative approach derived from quality function deployment techniques (QFD Matrix). This methodology aims to weigh the full environmental, cost, safety, reliability, and programmatic implications of replacement technology development to allow appropriate identification of viable candidates and programmatic alternatives. The results are being implemented as a guideline for consideration for current NASA propulsion systems.

The Blended Learning Environment: A Viable Alternative for Special Needs Students

ERIC Educational Resources Information Center

Rivera, Jennifer Hall

2017-01-01

The traditional classroom provides a classical medium for educating students by allowing an open forum of communication between the pupil and teacher. The last twenty-five years have opened a new realm of possibilities in education through the use of technology and virtual supplemental resources, designed to engage learners in all academic levels.…

Prioritization methodology for chemical replacement

NASA Technical Reports Server (NTRS)

Goldberg, Ben; Cruit, Wendy; Schutzenhofer, Scott

1995-01-01

This methodology serves to define a system for effective prioritization of efforts required to develop replacement technologies mandated by imposed and forecast legislation. The methodology used is a semi quantitative approach derived from quality function deployment techniques (QFD Matrix). QFD is a conceptual map that provides a method of transforming customer wants and needs into quantitative engineering terms. This methodology aims to weight the full environmental, cost, safety, reliability, and programmatic implications of replacement technology development to allow appropriate identification of viable candidates and programmatic alternatives.

The GreenLab Research Facility: A Micro-Grid Integrating Production, Consumption and Storage of Clean Energy

NASA Technical Reports Server (NTRS)

McDowell Bomani, Bilal Mark; Elbuluk, Malik; Fain, Henry; Kankam, Mark D.

2012-01-01

There is a large gap between the production and demand for energy from alternative fuel and alternative renewable energy sources. The NASA Glenn Research Center (GRC) has initiated a laboratory-pilot study that concentrates on using biofuels as viable alternative fuel resources for the field of aviation, as well as, utilizing wind and solar technologies as alternative renewable energy resources, and in addition, the use of pumped water for storage of energy that can be retrieved through hydroelectric generation. This paper describes the GreenLab Research Facility and its power and energy sources with .recommendations for worldwide expansion and adoption of the concept of such a facility

Energy Demand and Resources of Japan. Volume I

DTIC Science & Technology

1973-08-01

political motives. Economically Japan would prefer to develop alternative sources of petroleum which are politically stable and geologically viable...situation in the next decade. History records, therefore, Jhat Japan did not suddenly burst upon the scene as an advanced technology, highly competitive...cov- ering cooperative offshore exploration and eventual pro- duction in southern Kalimantan and northern Sumatra. Japex-Indonesian Limited, for

A Qualitative Approach to Understanding the Role of Lecture Capture in Student Learning Experiences

ERIC Educational Resources Information Center

Hall, Gareth; Ivaldi, Antonia

2017-01-01

Lectures continue to be the dominant form of university teaching, and lecture capture technologies are tentatively taken up to support this form of delivery, rather than being used as a viable alternative. Much of the previous research, however, has been self-reports or survey-based, with far less attention given to qualitative explorations. This…

Photovoltaic power - An important new energy option

NASA Technical Reports Server (NTRS)

Ferber, R. R.

1983-01-01

A review of photovoltaic (PV) power technology is presented with an emphasis of PV as an economical and technically feasible alternative source of energy. The successful completion of the development and transfer of emerging low-cost technologies into a fully commercialized status are identified as the means to the realization of this option's full potential. The DOE National Photovoltaics Program, a significant sponsor of PV R&D, expects both flat-plate and concentrator collectors to meet established cost targets. Citing the DOE large flat-plate grid-connected system project of the Sacramento Municipal Utility District, current technology modules priced at near $5/Wp (1983 dollars) are steadily reducing costs. A recent DOE study suggests that PV-generated electricity produced at a 30-year levelized cost of 15 cents per kWh would represent a viable energy supply alternative for the nation.

Photovoltaic power - An important new energy option

NASA Astrophysics Data System (ADS)

Ferber, R. R.

1983-12-01

A review of photovoltaic (PV) power technology is presented with an emphasis of PV as an economical and technically feasible alternative source of energy. The successful completion of the development and transfer of emerging low-cost technologies into a fully commercialized status are identified as the means to the realization of this option's full potential. The DOE National Photovoltaics Program, a significant sponsor of PV R&D, expects both flat-plate and concentrator collectors to meet established cost targets. Citing the DOE large flat-plate grid-connected system project of the Sacramento Municipal Utility District, current technology modules priced at near $5/Wp (1983 dollars) are steadily reducing costs. A recent DOE study suggests that PV-generated electricity produced at a 30-year levelized cost of 15 cents per kWh would represent a viable energy supply alternative for the nation.

A methodology for the comparative evaluation of alternative bioseparation technologies.

PubMed

Tran, Richard; Zhou, Yuhong; Lacki, Karol M; Titchener-Hooker, Nigel J

2008-01-01

Advances in upstream technologies and growing commercial demand have led to cell culture processes of ever larger volumes and expressing at higher product titers. This has increased the burden on downstream processing. Concerns regarding the capacity limitations of packed-bed chromatography have led process engineers to begin investigating new bioseparation techniques that may be considered as "alternatives" to chromatography, and which could potentially offer higher processing capacities but at a lower cost. With the wide range of alternatives, which are currently available, each with their own strengths and inherent limitations, coupled with the time pressures associated with process development, the challenge for process engineers is to determine which technologies are most worth investigating. This article presents a methodology based on a multiattribute decision making (MADM) analysis approach, utilizing both quantitative and qualitative data, which can be used to determine the "industrial attractiveness" of bioseparation technologies, accounting for trade-offs between their strengths and weaknesses. By including packed-bed chromatography in the analysis as a reference point, it was possible to determine the alternatives, which show the most promise for use in large-scale manufacturing processes. The results of this analysis show that although the majority of alternative techniques offer certain advantages over conventional packed-bed chromatography, their attractiveness overall means that currently none of these technologies may be considered as viable alternatives to chromatography. The methodology introduced in this study may be used to gain significant quantitative insight as to the key areas in which improvements are required for each technique, and thus may be used as a tool to aid in further technological development.

Earth land landing alternatives: Lunar transportation system

NASA Technical Reports Server (NTRS)

Meyerson, Robert

1992-01-01

The objectives of this study are as follows: (1) develop a landing option such that it is a viable trade option for future NASA missions; (2) provide NASA programs with solid technical support in the landing systems area; (3) develop the technical staff; and (4) advance the state of landing systems technology to apply to future NASA missions. All results are presented in viewgraph format.

Energy conservation and the transportation sector

NASA Technical Reports Server (NTRS)

1975-01-01

The present status of the energy implications of the transportation systems in the United States was illustrated, with primary emphasis on the technologies and methods for achieving a substantial reduction in the associated energy price (approximately 25% of the nation's energy is consumed directly in the operation of these systems). These technologies may be classified as follows: (1) improvement of system efficiency (system operations or technological), (2) substitution for scarce energy resources (electrification, alternate fuels, use of man power, recycling), (3) curtailment of end use (managed population growth rate, education of citizenry, alternatives to personal transportation, improved urban planning, reduced travel incentives). Examples and illustrations were given. Thirty-four actions were chosen on the basis of a preliminary filtering process with the objective of: (1) demonstrating a methodological approach to arrive at logical and consistent conservation action packages, (2) recommending a viable and supportable specific set of actions.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Middleton, Richard S.; Levine, Jonathan S.; Bielicki, Jeffrey M.

CO 2 capture, utilization, and storage (CCUS) technology has yet to be widely deployed at a commercial scale despite multiple high-profile demonstration projects. We suggest that developing a large-scale, visible, and financially viable CCUS network could potentially overcome many barriers to deployment and jumpstart commercial-scale CCUS. To date, substantial effort has focused on technology development to reduce the costs of CO 2 capture from coal-fired power plants. Here, we propose that near-term investment could focus on implementing CO 2 capture on facilities that produce high-value chemicals/products. These facilities can absorb the expected impact of the marginal increase in the costmore » of production on the price of their product, due to the addition of CO 2 capture, more than coal-fired power plants. A financially viable demonstration of a large-scale CCUS network requires offsetting the costs of CO 2 capture by using the CO 2 as an input to the production of market-viable products. As a result, we demonstrate this alternative development path with the example of an integrated CCUS system where CO 2 is captured from ethylene producers and used for enhanced oil recovery in the U.S. Gulf Coast region.« less

Cryogenic Propellant Storage and Transfer Technology Demonstration: Prephase A Government Point-of-Departure Concept Study

NASA Technical Reports Server (NTRS)

Mulqueen, J. A.; Addona, B. M.; Gwaltney, D. A.; Holt, K. A.; Hopkins, R. C.; Matis, J. A.; McRight, P. S.; Popp, C. G.; Sutherlin, S. G.; Thomas, H. D.;

Integrated hydrogen/oxygen technology applied to auxiliary propulsion systems

NASA Technical Reports Server (NTRS)

Gerhardt, David L.

1990-01-01

The purpose of the Integrated Hydrogen/Oxygen Technology (IHOT) study was to determine if the vehicle/mission needs and technology of the 1990's support development of an all cryogenic H2/O2 system. In order to accomplish this, IHOT adopted the approach of designing Integrated Auxiliary Propulsion Systems (IAPS) for a representative manned vehicle; the advanced manned launch system. The primary objectives were to develop IAPS concepts which appeared to offer viable alternatives to state-of-the-art (i.e., hypergolic, or earth-storable) APS approaches. The IHOT study resulted in the definition of three APS concepts; two cryogenic IAPS, and a third concept utilizing hypergolic propellants.

Manufacturing with the Sun

NASA Astrophysics Data System (ADS)

Murphy, L. M.; Hauser, S. G.; Clyne, R. J.

1992-05-01

Concentrated solar radiation is now a viable alternative energy source for many advanced manufacturing processes. Researchers at the National Renewable Energy Laboratory (NREL) have demonstrated the feasibility of processes such as solar-induced surface transformation of materials (SISTM), solar-based manufacturing, and solar-pumped lasers. Researchers are also using sunlight to decontaminate water and soils polluted with organic compounds; these techniques could provide manufacturers with innovative alternatives to traditional methods of waste management. The solar technology that is now being integrated into today's manufacturing processes offers even greater potential for tomorrow, especially as applied to the radiation-abundant environment available in space and on the lunar surface.

Manufacturing with the Sun

NASA Astrophysics Data System (ADS)

Murphy, Lawrence M.; Hauser, Steven G.; Clyne, Richard J.

1991-12-01

Concentrated solar radiation is now a viable alternative source for many advanced manufacturing processes. Researchers at the National Renewable Energy Laboratory (NREL) have demonstrated the feasibility of processes such as solar induced surface transformation of materials (SISTM), solar based manufacturing, and solar pumped lasers. Researchers are also using sunlight to decontaminate water and soils polluted with organic compounds; these techniques could provide manufacturers with innovative alternatives to traditional methods of waste management. The solar technology that is now being integrated into today's manufacturing processes offer greater potential for tomorrow, especially as applied to the radiation abundant environment available in space and on the lunar surface.

Manufacturing with the Sun

NASA Technical Reports Server (NTRS)

Murphy, Lawrence M.; Hauser, Steven G.; Clyne, Richard J.

1991-01-01

Concentrated solar radiation is now a viable alternative source for many advanced manufacturing processes. Researchers at the National Renewable Energy Laboratory (NREL) have demonstrated the feasibility of processes such as solar induced surface transformation of materials (SISTM), solar based manufacturing, and solar pumped lasers. Researchers are also using sunlight to decontaminate water and soils polluted with organic compounds; these techniques could provide manufacturers with innovative alternatives to traditional methods of waste management. The solar technology that is now being integrated into today's manufacturing processes offer greater potential for tomorrow, especially as applied to the radiation abundant environment available in space and on the lunar surface.

Cost-Benefit Analysis For Alternative Low-Emission Surface Preparation/ Depainting Technologies for Structural Steel

NASA Technical Reports Server (NTRS)

Lewis, Pattie

2007-01-01

Stennis Space Center (SSC), Kennedy Space Center (KSC) and Air Force Space Command (AFSPC) identified particulate emissions and waste generated from the depainting process of steel structures as hazardous materials to be eliminated or reduced. A Potential Alternatives Report, Potential Alternatives Report for Validation of Alternative Low Emission Surface Preparation/Depainting Technologies for Structural Steel, provided a technical analyses of identified alternatives to the current coating removal processes, criteria used to select alternatives for further analysis, and a list of those alternatives recommended for testing. The initial coating removal alternatives list was compiled using literature searches and stakeholder recommendations. The involved project participants initially considered approximately 13 alternatives. In late 2003, core project members selected the following depainting processes to be further evaluated: (1) Plastic Blast Media-Quickstrip(R)-A. (2) Hard Abrasive-Steel-Magic(R). (3) Sponge Blasting-Sponge-Jet(R). (4) Liquid Nitrogen-NItroJet(R). (5) Mechanical Removal with Vacuum Attachment-DESCO and OCM Clean-Air (6) Laser Coating Removal Alternatives were tested in accordance with the Joint Test Protocol for Validation of Alternative Low-Emission Surface Preparation/Depainting Technologies for Structural Steel, and the Field Evaluation Test Plan for Validation of Alternative Low-Emission Surface Preparation/Depainting Technologies for Structural Steel. Results of the testing are documented in the Joint Test Report. This Cost-Benefit Analysis (CBA) focuses on the three alternatives (Quickstrip(R)-A, SteelMagic (R), and Sponge-Jet(R)) that were considered viable alternatives for large area operations based on the results of the field demonstration and lab testing. This CBA was created to help participants determine if implementation of the candidate alternatives is economically justified. Each of the alternatives examined reduced Environmental Activity (EA) Costs-those costs associated with complying with environmental regulations. One alternative, Steel-Magic(R), also showed reduced Direct Costs and reduced total costs.

Air pollution control residues from waste incineration: current UK situation and assessment of alternative technologies.

PubMed

Rani, D Amutha; Boccaccini, A R; Deegan, D; Cheeseman, C R

2008-11-01

Current disposal options for APC residues in the UK and alternative treatment technologies developed world-wide have been reviewed. APC residues are currently landfilled in the UK where they undergo in situ solidification, although the future acceptability of this option is uncertain because the EU waste acceptance criteria (WAC) introduce strict limits on leaching that are difficult to achieve. Other APC residue treatment processes have been developed which are reported to reduce leaching to below relevant regulatory limits. The Ferrox process, the VKI process, the WES-PHix process, stabilisation/solidification using cementitious binders and a range of thermal treatment processes are reviewed. Thermal treatment technologies convert APC residues combined with other wastes into inert glass or glass-ceramics that encapsulate heavy metals. The waste management industry will inevitably use the cheapest available option for treating APC residues and strict interpretation and enforcement of waste legislation is required if new, potentially more sustainable technologies are to become commercially viable.

Jet Fuel from Shale Oil - 1981 Technology Review,

DTIC Science & Technology

1981-12-01

the programs just described by Mr Jackson in the previous papaer . F. N. Hodgson of the Mon- santo Research Center provided mass spectrometric... research and development efforts at alleviating the magnitude of the problem and its impact on national security by evaluating the potential of...with Exxon Research and Engineering, domestic oil shale was determined to be the most viable near term alternative source of syncrude available for

The Role of Oxophytodienoate Reductases in the Detoxification of the Explosive 2,4,6-Trinitrotoluene by Arabidopsis

DTIC Science & Technology

2009-09-01

and recalcitrant to degradation. Phytoremediation is being increasingly proposed as a viable alternative to conventional remediation technologies to...mediating the detoxification of TNT in plants (for review, see Rylott and Bruce, 2009). Phytoremediation , the use of plants to remove en- vironmental...4742–4750 Rylott EL, Bruce NC (2009) Plants disarm soil: engineering plants for the phytoremediation of explosives. Trends Biotechnol 27: 73–81

Microbial fuel cells as an alternative energy source: current status.

PubMed

Javed, Muhammad Mohsin; Nisar, Muhammad Azhar; Ahmad, Muhammad Usman; Yasmeen, Nighat; Zahoor, Sana

2018-06-22

Microbial fuel cell (MFC) technology is an emerging area for alternative renewable energy generation and it offers additional opportunities for environmental bioremediation. Recent scientific studies have focused on MFC reactor design as well as reactor operations to increase energy output. The advancement in alternative MFC models and their performance in recent years reflect the interests of scientific community to exploit this technology for wider practical applications and environmental benefit. This is reflected in the diversity of the substrates available for use in MFCs at an economically viable level. This review provides an overview of the commonly used MFC designs and materials along with the basic operating parameters that have been developed in recent years. Still, many limitations and challenges exist for MFC development that needs to be further addressed to make them economically feasible for general use. These include continued improvements in fuel cell design and efficiency as well scale-up with economically practical applications tailored to local needs.

Fused-core particle technology as an alternative to sub-2-microm particles to achieve high separation efficiency with low backpressure.

PubMed

Cunliffe, Jennifer M; Maloney, Todd D

2007-12-01

Fused-Core particles have recently been introduced as an alternative to using sub-2-microm particles in chromatographic separations. Fused-Core particles are composed of a 1.7 microm solid core surrounded by a 0.5 microm porous silica layer (d(p) = 2.7 microm) to reduce mass transfer and increase peak efficiency. The performance of two commercially available Fused-Core particles (Advanced Materials Technology Halo C18 and Supelco Ascentis Express C18) was compared with sub-2-microm particles from Waters, Agilent, and Thermo Scientific. Although the peak efficiencies were only approximately 80% of those obtained by the Waters Acquity particles, the 50% lower backpressure allowed columns to be coupled in series to increase peak efficiency to 92,750 plates. The low backpressure and high efficiencies of the Fused-Core particles offer a viable alternative to using sub-2-microm particles and very-high-pressure LC instrumentation.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Restivo, M.

SRNL Environmental and Chemical Process Technology (E&CPT) was requested to perform testing of vacuum pumps per a verbal request from the Customer, SRNL Hydrogen Processing Technology. Tritium Operations is currently having difficulties procuring the Normetex™® Model 15 m 3/hr (9 CFM) vacuum pump (formerly Normetex Pompes, now Eumeca SARL). One possible solution proposed by Hydrogen Processing Technology personnel is to use two Senior Aerospace Metal Bellows MB-601 vacuum pumps piped with the heads in series, and the pumps in series (Figure 1 below). This memorandum documents the ultimate vacuum testing that was performed to determine if this concept was amore » viable alternate vacuum pump strategy. This testing dovetails with previous pump evaluations documented in references 1 and 2.« less

Jumpstarting commercial-scale CO 2 capture and storage with ethylene production and enhanced oil recovery in the US Gulf

DOE PAGES

Middleton, Richard S.; Levine, Jonathan S.; Bielicki, Jeffrey M.; ...

2015-04-27

CO 2 capture, utilization, and storage (CCUS) technology has yet to be widely deployed at a commercial scale despite multiple high-profile demonstration projects. We suggest that developing a large-scale, visible, and financially viable CCUS network could potentially overcome many barriers to deployment and jumpstart commercial-scale CCUS. To date, substantial effort has focused on technology development to reduce the costs of CO 2 capture from coal-fired power plants. Here, we propose that near-term investment could focus on implementing CO 2 capture on facilities that produce high-value chemicals/products. These facilities can absorb the expected impact of the marginal increase in the costmore » of production on the price of their product, due to the addition of CO 2 capture, more than coal-fired power plants. A financially viable demonstration of a large-scale CCUS network requires offsetting the costs of CO 2 capture by using the CO 2 as an input to the production of market-viable products. As a result, we demonstrate this alternative development path with the example of an integrated CCUS system where CO 2 is captured from ethylene producers and used for enhanced oil recovery in the U.S. Gulf Coast region.« less

Review of alternate automotive engine fuel economy. Final report January-October 78

DOE Office of Scientific and Technical Information (OSTI.GOV)

Cole, D.; Bolt, J.A.; Huber, P.

This study assessed the potential of alternate automotive engines to meet the fuel economy goals and emission levels of the 1980-1990 period. As part of NHTSA's continuing research in support of the Department of Transportation fuel economy activities, this study reviewed those developments offering viable substitutes for the current spark ignition engine systems. Categories assessed included stratified charge, diesels, turbo charging, rotary/Wankel engines, and the developmental gas turbine and Stirling cycle engines. Results of past and on-going research through 1978 were reviewed along with the development and production status of various alternate engine technologies proposed for automobiles and light trucksmore » through the 1980s. Assessment was then made of the potential fuel economy improvement as a percentage of 1978 baseline data.« less

Lease/Purchase: A Viable Alternative for Financing Schools.

ERIC Educational Resources Information Center

Demers, Denise

1989-01-01

Lease-purchase finance is a viable alternative for school districts that cannot or do not want to employ traditional financing techniques. Outlines the advantages and disadvantages of lease-purchase financing compared to outright purchase; operating leasing, which is taxable; and traditional tax-exempt bond financing. (MLF)

Translational bioinformatics in the cloud: an affordable alternative

PubMed Central

2010-01-01

With the continued exponential expansion of publicly available genomic data and access to low-cost, high-throughput molecular technologies for profiling patient populations, computational technologies and informatics are becoming vital considerations in genomic medicine. Although cloud computing technology is being heralded as a key enabling technology for the future of genomic research, available case studies are limited to applications in the domain of high-throughput sequence data analysis. The goal of this study was to evaluate the computational and economic characteristics of cloud computing in performing a large-scale data integration and analysis representative of research problems in genomic medicine. We find that the cloud-based analysis compares favorably in both performance and cost in comparison to a local computational cluster, suggesting that cloud computing technologies might be a viable resource for facilitating large-scale translational research in genomic medicine. PMID:20691073

Space power system design and development from an economic point of view

NASA Technical Reports Server (NTRS)

Hazelrigg, G. A., Jr.

1977-01-01

The concept of a satellite solar power system offers a feasible, but unproven, long-range energy alternative. While the basic physics of these systems is understood, many developments are necessary in order to reduce the system cost to the point of being cost-competitive with alternative energy sources. Thus, a substantial technology advancement and verification program, plus test and demonstration satellite programs are necessary before a full-scale satellite can be designed and built. It is important to properly identify those elements of the technology that should be subject to development efforts, the goals of the corresponding development programs and the appropriate funding levels and schedules. Systems studies and designs play a major role in rationally formulating a development program. This paper uses an economic approach to place these studies into a framework for formulating a viable satellite solar power system development plan.

Potential Alternatives Report for Validation of Alternatives to Aliphatic Isocyanate Polyurethanes

NASA Technical Reports Server (NTRS)

Lewis, pattie

2011-01-01

Identifying and selecting alternative materials and technologies that have the potential to reduce the identified HazMats and hazardous air pollutants (HAPs), while incorporating sound corrosion prevention and control technologies, is a complicated task due to the fast pace at which new technologies emerge and rules change. The alternatives are identified through literature searches, electronic database and Internet searches, surveys, and/or personal and professional contacts. Available test data was then compiled on the proposed alternatives to determine if the materials meet the test objectives or if further)laboratory or field-testing will be required. After reviewing technical information documented in the PAR, government representatives, technical representatives from the affected facilities, and other stakeholders involved in the process will select the list of viable alternative coatings for consideration and testing under the project's Joint Test Protocol entitled Joint Test Protocol for Validation of Alternatives to Aliphatic Isocyanate Polyurethanes and Field Test Plan entitled Field Evaluations Test Plan for Validation of Alternatives to Aliphatic Isocyanate Polyurethanes, both prepared by ITB. Test results will be reported in a Joint Test Report upon completion oftesting. The selection rationale and conclusions are documented in this PAR. A cost benefit analysis will be prepared to quantify the estimated capital and process costs of coating alternatives and cost savings relative to the current coating processes, however, some initial cost data has been included in this PAR. For this coatings project, isocyanates, as found in aliphatic isocyanate polyurethanes, were identified as the target HazMat to be eliminated. Table 1-1 lists the target HazMats, the related process and application, current specifications, and affected programs.

An Overview of Magnetic Bearing Technology for Gas Turbine Engines

NASA Technical Reports Server (NTRS)

Clark, Daniel J.; Jansen, Mark J.; Montague, Gerald T.

2004-01-01

The idea of the magnetic bearing and its use in exotic applications has been conceptualized for many years, over a century, in fact. Patented, passive systems using permanent magnets date back over 150 years. More recently, scientists of the 1930s began investigating active systems using electromagnets for high-speed ultracentrifuges. However, passive magnetic bearings are physically unstable and active systems only provide proper stiffness and damping through sophisticated controllers and algorithms. This is precisely why, until the last decade, magnetic bearings did not become a practical alternative to rolling element bearings. Today, magnetic bearing technology has become viable because of advances in micro-processing controllers that allow for confident and robust active control. Further advances in the following areas: rotor and stator materials and designs which maximize flux, minimize energy losses, and minimize stress limitations; wire materials and coatings for high temperature operation; high-speed micro processing for advanced controller designs and extremely robust capabilities; back-up bearing technology for providing a viable touchdown surface; and precision sensor technology; have put magnetic bearings on the forefront of advanced, lubrication free support systems. This paper will discuss a specific joint program for the advancement of gas turbine engines and how it implies the vitality of magnetic bearings, a brief comparison between magnetic bearings and other bearing technologies in both their advantages and limitations, and an examination of foreseeable solutions to historically perceived limitations to magnetic bearing.

Renewable Hydrogen-Economically Viable: Integration into the U.S. Transportation Sector

DOE Office of Scientific and Technical Information (OSTI.GOV)

Kurtz, Jennifer; Peters, Mike; Muratori, Matteo

The U.S. transportation sector is expected to meet numerous goals in differing applications. These goals address security, safety, fuel source, emissions reductions, advanced mobility models, and improvements in quality and accessibility. Solutions to meeting these goals include a variety of alternative-fuel technologies, including batteries, fuel cells, synthetic fuels, and biofuels, as well as modifying how current transportation systems are used and integrating new systems, such as storing renewable energy. Overall, there are many combinations of problems, objectives, and solutions.

Investigations of the environmental acceptability of fluorocarbon alternatives to chlorofluorocarbons.

PubMed Central

McFarland, M

1992-01-01

Chlorofluorocarbons (CFCs) are currently used in systems for preservation of perishable foods and medical supplies, increasing worker productivity and consumer comfort, conserving energy and increasing product reliability. As use of CFCs is phased out due to concerns of ozone depletion, a variety of new chemicals and technologies will be needed to serve these needs. In choosing alternatives, industry must balance concerns over safety and environmental acceptability and still meet the preformance characteristics of the current technology, the only viable alternatives meeting the safety, performance, and environmental requirements for the remaining 40% of demand are fluorocarbons, hydrochlorofluorocarbons (HCFs), and hydrofluorocarbons (HFCs). HCFCs and HFCs possess many of the desirable properties of the CFCs, but because of the, hydrogen, they results in shorter atmospheric lifetimes compared to CFCs and reduces their potential to contribute to stratospheric ozone depletion or global warming; HFCs do not contain chlorine and have no potential to destroy ozone. This paper provides an overview of challenges faced by industry, regulators, and society in general in continuing to meet societal needs and consumer demands while reducing risk to the enviroment without compromising consumer or worker safety. PMID:11607257

Strategic Technologies for Deep Space Transport

NASA Technical Reports Server (NTRS)

Litchford, Ronald J.

2016-01-01

Deep space transportation capability for science and exploration is fundamentally limited by available propulsion technologies. Traditional chemical systems are performance plateaued and require enormous Initial Mass in Low Earth Orbit (IMLEO) whereas solar electric propulsion systems are power limited and unable to execute rapid transits. Nuclear based propulsion and alternative energetic methods, on the other hand, represent potential avenues, perhaps the only viable avenues, to high specific power space transport evincing reduced trip time, reduced IMLEO, and expanded deep space reach. Here, key deep space transport mission capability objectives are reviewed in relation to STMD technology portfolio needs, and the advanced propulsion technology solution landscape is examined including open questions, technical challenges, and developmental prospects. Options for potential future investment across the full compliment of STMD programs are presented based on an informed awareness of complimentary activities in industry, academia, OGAs, and NASA mission directorates.

[Aedes aegypti control strategies: a review].

PubMed

Zara, Ana Laura de Sene Amâncio; Santos, Sandra Maria Dos; Fernandes-Oliveira, Ellen Synthia; Carvalho, Roberta Gomes; Coelho, Giovanini Evelim

2016-01-01

to describe the main strategies to control Aedes aegypti, with emphasis on promising technological innovations for use in Brazil. this study is a non-systematic review of the literature. several technologies have been developed as alternatives in the control of Ae. aegypti, using different mechanisms of action, such as selective monitoring of the infestation, social interventions, dispersing insecticides, new biological control agents and molecular techniques for population control of mosquitoes, also considering the combination between them. Evolving technologies require evaluation of the effectiveness, feasibility and costs of implementation strategies as complementary to the actions already recommended by the National Program for Dengue Control. the integration of different compatible and effective vector control strategies, considering the available technologies and regional characteristics, appears to be a viable method to try to reduce the infestation of mosquitoes and the incidence of arbovirus transmitted by them.

Evaluation of a Hydrogen Fuel Cell Powered Blended-Wing-Body Aircraft Concept for Reduced Noise and Emissions

NASA Technical Reports Server (NTRS)

Guynn, Mark D.; Freh, Joshua E.; Olson, Erik D.

2004-01-01

This report describes the analytical modeling and evaluation of an unconventional commercial transport aircraft concept designed to address aircraft noise and emission issues. A blended-wing-body configuration with advanced technology hydrogen fuel cell electric propulsion is considered. Predicted noise and emission characteristics are compared to a current technology conventional configuration designed for the same mission. The significant technology issues which have to be addressed to make this concept a viable alternative to current aircraft designs are discussed. This concept is one of the "Quiet Green Transport" aircraft concepts studied as part of NASA's Revolutionary Aerospace Systems Concepts (RASC) Program. The RASC Program was initiated to develop revolutionary concepts that address strategic objectives of the NASA Enterprises, such as reducing aircraft noise and emissions, and to identify advanced technology requirements for the concepts.

Strategic Technology Investment Analysis: An Integrated System Approach

NASA Technical Reports Server (NTRS)

Adumitroaie, V.; Weisbin, C. R.

2010-01-01

Complex technology investment decisions within NASA are increasingly difficult to make such that the end results are satisfying the technical objectives and all the organizational constraints. Due to a restricted science budget environment and numerous required technology developments, the investment decisions need to take into account not only the functional impact on the program goals, but also development uncertainties and cost variations along with maintaining a healthy workforce. This paper describes an approach for optimizing and qualifying technology investment portfolios from the perspective of an integrated system model. The methodology encompasses multi-attribute decision theory elements and sensitivity analysis. The evaluation of the degree of robustness of the recommended portfolio provides the decision-maker with an array of viable selection alternatives, which take into account input uncertainties and possibly satisfy nontechnical constraints. The methodology is presented in the context of assessing capability development portfolios for NASA technology programs.

Electric Drive Dynamic Thermal System Model for Advanced Vehicle Propulsion Technologies: Cooperative Research and Development Final Report, CRADA Number CRD-09-360

DOE Office of Scientific and Technical Information (OSTI.GOV)

Bennion, K.

Electric drive systems, which include electric machines and power electronics, are a key enabling technology for advanced vehicle propulsion systems that reduce the dependence of the U.S. transportation sector on petroleum. However, to penetrate the market, these electric drive technologies must enable vehicle solutions that are economically viable. The push to make critical electric drivesystems smaller, lighter, and more cost-effective brings respective challenges associated with heat removal and system efficiency. In addition, the wide application of electric drive systems to alternative propulsion technologies ranging from integrated starter generators, to hybrid electric vehicles, to full electric vehicles presents challenges in termsmore » of sizing critical components andthermal management systems over a range of in-use operating conditions. This effort focused on developing a modular modeling methodology to enable multi-scale and multi-physics simulation capabilities leading to generic electric drive system models applicable to alternative vehicle propulsion configurations. The primary benefit for the National Renewable Energy Laboratory (NREL) is the abilityto define operating losses with the respective impact on component sizing, temperature, and thermal management at the component, subsystem, and system level. However, the flexible nature of the model also allows other uses related to evaluating the impacts of alternative component designs or control schemes depending on the interests of other parties.« less

Total Life Cycle-Based Materials Selection for Polymer Metal Hybrid Body-in-White Automotive Components

NASA Astrophysics Data System (ADS)

Grujicic, M.; Sellappan, V.; He, T.; Seyr, Norbert; Obieglo, Andreas; Erdmann, Marc; Holzleitner, Jochen

2009-03-01

Over the last dozen of years, polymer metal hybrid (PMH) technologies have established themselves as viable alternatives for use in light-weight automotive body-in-white bolt-on as well as load-bearing (structural) components. Within the PMH technologies, sheet-metal stamped/formed and thermoplastic injection molding subcomponents are integrated into a singular component/module. Due to attending synergetic effects, the performance of the PMH component typically exceeds that attainable by an alternative single-material technologies. In the present work, a total life cycle (TLC) approach to the selection of metallic and thermoplastic materials (as well as the selection of structural adhesives, where appropriate) is considered. The TLC material selection approach considers the consequences and ramifications of material selection at each major stage of the vehicle manufacturing process chain (press shop, injection molding shop, body shop, paint shop, and assembly), as well as relation to the vehicle performance, durability and the end-of-the-life-of-the-vehicle considerations. The approach is next applied to the case of injection overmolding technology to identify the optimal grade of short glass-fiber reinforced nylon when used in a prototypical PMH load-bearing automotive body-in-white component.

Metallurgical Evaluations of Depainting Processes on Aluminum Substrate

NASA Technical Reports Server (NTRS)

McGill, Preston

1999-01-01

In December 1993, the Environmental Protection Agency (EPA) Emission Standards Division and the National Aeronautics and Space Administration's (NASA's) Marshall Space Flight Center (MSFC) signed an Interagency Agreement (IA) initiating a task force for the technical assessment of alternative technologies for aerospace depainting operations. The United States Air Force (USAF) joined the task force in 1994. The mandates of the task force were: (1) To identify available alternative depainting systems that do not rely on methylene chloride or other ozone-depleting, chlorinated, and volatile organic carbon solvents. (2) To determine the viability, applicability, and pollution prevention potential of each identified alternative. (3) To address issues of safety, environmental impact, reliability, and maintainability. Through a Technical Implementation Committee (TIC), the task force selected and evaluated eight alternative paint stripping technologies: chemical stripping, carbon dioxide (CO2) blasting, xenon flashlamp and CO2 coatings removal (FLASHJET(R)), CO2 laser stripping, plastic media blasting (PMB), sodium bicarbonate wet stripping, high-pressure water blasting (WaterJet), and wheat starch abrasive blasting (Enviro-Strip(R)). (The CO2 blasting study was discontinued after the first depainting sequence.) This final report presents the results of the Joint EPA/NASA/USAF Interagency Depainting Study. Significant topics include: (1) Final depainting sequence data for the chemical stripping, PMB, sodium bicarbonate wet stripping, and WaterJet processes. (2) Strip rates for all eight technologies. (3) Sequential comparisons of surface roughness measurements for the seven viable depainting technologies. (4) Chronological reviews of and lessons learned in the conduct of all eight technologies. (5) An analysis of the surface roughness trends for each of the seven technologies. (6) Metallurgic evaluations of panels Summaries of corrosion and hydrogen embrittlement evaluations of chemical stripping panels, detailed descriptions of which appear in previous reports. Because the requirements for alternative systems are diverse, as are initial setup, training, and on-going operational considerations, this study does not recommend a particular product or process. Users of this study will draw their own conclusions from the data presented herein.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Mays, Jeff

One-step hydrogen generation, using Sorption Enhanced Reforming (SER) technology, is an innovative means of providing critical energy and environmental improvements to US manufacturing processes. The Gas Technology Institute (GTI) is developing a Compact Hydrogen Generator (CHG) process, based on SER technology, which successfully integrates previously independent process steps, achieves superior energy efficiency by lowering reaction temperatures, and provides pathways to doubling energy productivity with less environmental pollution. GTI’s prior CHG process development efforts have culminated in an operational pilot plant. During the initial pilot testing, GTI identified two operating risks- 1) catalyst coating with calcium aluminate compounds, 2) limited solidsmore » handling of the sorbent. Under this contract GTI evaluated alternative materials (one catalyst and two sorbents) to mitigate both risks. The alternate catalyst met performance targets and did not experience coating with calcium aluminate compounds of any kind. The alternate sorbent materials demonstrated viable operation, with one material enabling a three-fold increase in sorbent flow. The testing also demonstrated operation at 90% of its rated capacity. Lastly, a carbon dioxide co-production study was performed to assess the advantage of the solid phase separation of carbon dioxide- inherent in the CHG process. Approximately 70% lower capital cost is achievable compared to SMR-based hydrogen production with CO2 capture, as well as improved operating costs.« less

Technology needs for high speed rotorcraft (2)

NASA Technical Reports Server (NTRS)

Scott, Mark W.

1991-01-01

An analytical study was conducted to identify rotorcraft concepts best capable of combining a cruise speed of 350 to 450 knots with helicopter-like low speed attributes, and to define the technology advancements needed to make them viable by the year 2000. A systematic approach was used to compare the relative attributes and mission gross weights for a wide range of concepts, resulting in a downselect to the most promising concept/mission pairs. For transport missions, tilt-wing and variable diameter tilt-rotor (VDTR) concepts were found to be superior. For a military scout/attack role, the VDTR was best, although a shrouded rotor concept could provide a highly agile, low observable alternative if its weight empty fraction could be reduced. A design speed of 375 to 425 knots was found to be the maximum desirable for transport missions, with higher speed producing rapidly diminishing benefits in productivity. The key technologies that require advancement to make the tilt-wing and VDTR concepts viable are in the areas of wing and proprotor aerodynamics, efficient structural design, flight controls, refinement of the geared flap pitch control system, expansion of the speed/descent envelope, and the structural and aerodynamic tradeoffs of wing thickness and forward sweep. For the shrouded rotor, weight reduction is essential, particularly with respect to the mechanism for covering the rotor in cruise.

Hydrogen production by Cyanobacteria.

PubMed

Dutta, Debajyoti; De, Debojyoti; Chaudhuri, Surabhi; Bhattacharya, Sanjoy K

2005-12-21

The limited fossil fuel prompts the prospecting of various unconventional energy sources to take over the traditional fossil fuel energy source. In this respect the use of hydrogen gas is an attractive alternate source. Attributed by its numerous advantages including those of environmentally clean, efficiency and renew ability, hydrogen gas is considered to be one of the most desired alternate. Cyanobacteria are highly promising microorganism for hydrogen production. In comparison to the traditional ways of hydrogen production (chemical, photoelectrical), Cyanobacterial hydrogen production is commercially viable. This review highlights the basic biology of cynobacterial hydrogen production, strains involved, large-scale hydrogen production and its future prospects. While integrating the existing knowledge and technology, much future improvement and progress is to be done before hydrogen is accepted as a commercial primary energy source.

Deep Brain Stimulation as a Treatment for Refractory Epilepsy: Review of the Current State-of-the-Art.

PubMed

Ganguli, Malika P; Upton, Adrian R M; Kamath, Markad V

2017-01-01

Epilepsy affects ∼ 1% of the global population, and 33% of patients are nonresponsive to medication and must seek alternative treatment options. Alternative options such as surgery and ablation exist but are not appropriate treatment plans for some patients. Neurostimulation methods such as vagal nerve stimulation, responsive neural stimulation, and deep brain stimulation (DBS) are viable alternatives for medically refractory patients. DBS stimulation has been used in the treatment of Parkinson's disease, dystonia, and pain management. For the treatment of epilepsy, DBS has been found to be an effective treatment plan, with promising results of reduced seizure frequency and intensity. In this review, we discuss DBS surgery and equipment, mechanisms of DBS for epilepsy, and efficacy, technological specifications, and suggestions for future research. We also review a historical summary of experiments involving DBS for epilepsy. Our literature review suggests that further studies are warranted for medically refractory epilepsy using DBS.

Progress Toward Cleanup of Operable Unit 1 Groundwater at the US DOE Mound, Ohio, Site: Success of a Phase-Combined Remedy – 15310

DOE Office of Scientific and Technical Information (OSTI.GOV)

Hooten, Gwendolyn; Cato, Rebecca; Looney, Brian

2015-03-01

Operable Unit 1 (OU-1) soil and groundwater have been affected by volatile organic compounds (VOC) Present groundwater remedy is collection, treatment, and disposal (pump and treat [P&T]) Several combinations of technologies were used to address soil and groundwater contamination Monitored natural attenuation (MNA) is a viable alternative Majority of source term has been excavated VOC concentrations in groundwater have decreased Attenuation mechanisms have been observed in the subsurface at OU-1

Practice Consolidation: Forces Not of Nature, but of Government, Demographics, Economics, and Technology.

PubMed

Edlow, Richard C

2016-01-01

The demand for healthcare services is increasing more rapidly than the supply of providers, while reimbursement levels ignore the free market law of supply and demand. The regulated healthcare environment in the United States fails to increase prices (i.e., reimbursement rates) as demand outstrips supply. Healthcare practitioners must find alternative methods in order to continue providing excellent patient care while at the same time maintaining an economically viable practice. Practice consolidation with the assistance of private equity healthcare investment is an extremely attractive solution to this imbalance.

Within-Subject Interlaboratory Variability of QuantiFERON-TB Gold In-Tube Tests

DTIC Science & Technology

2012-09-06

QuantiFERONH-TB Gold In-Tube test (QFT-GIT) is a viable alternative to the tuberculin skin test (TST) for detecting Mycobacterium tuberculosis infection...viable alternative to the tuberculin skin test (TST) for detecting Mycobacterium tuberculosis infection. However, within-subject variability may limit test...release assays (IGRAs) are designed to detect both latent Mycobacterium tuberculosis infection (LTBI) and infections manifesting as active

[Economic evaluation of social technologies applied to health promotion: water supply by the SODIS System in riverside communities of the Brazilian Amazon].

PubMed

Lobo, Marco Aurélio Arbage; Lima, Dula Maria Bento de; Souza, Cezarina Maria Nobre; Nascimento, Waddle Almeida; Araújo, Leiliane Cristina Cardoso; Santos, Neucy Barreto dos

2013-07-01

The so-called social technologies have been widely used in many places around the world as a viable alternative for low-income populations to gain access to opportunities for employment and income and other aspects related to quality of life, including basic sanitation. This paper conducts a cost-benefit analysis of using a low cost technology for drinking water used in several countries, namely the SODIS system. The study was conducted in riverside communities living in the island area of Belem municipality, located in the Brazilian Amazon. Data were collected through questionnaires answered by families living on three islands: Jutuba, Nova and Urubuoca. The results were positive, considering the cost-benefit analysis of the project, which demonstrates the economic viability of using the SODIS system in the situation investigated.

Highly valuable microalgae: biochemical and topological aspects.

PubMed

Pignolet, Olivier; Jubeau, Sébastien; Vaca-Garcia, Carlos; Michaud, Philippe

2013-08-01

The past decade has seen a surge in the interest in microalgae culture for biodiesel production and other applications as renewable biofuels as an alternative to petroleum transport fuels. The development of new technologies for the culture of these photosynthetic microorganisms and improved knowledge of their biochemical composition has spurred innovation in the field of high-value biomolecules. These developments are only economically viable if all the microalgae fractions are valorized in a biorefinery strategy. Achieving this objective requires an understanding of microalgae content and the cellular localization of the main biomolecular families in order to develop efficient harvest and sequential recovery technologies. This review summarizes the state of the art in microalgae compositions and topologies using some examples of the main industrially farmed microalgae.

Postoptimality Analysis in the Selection of Technology Portfolios

NASA Technical Reports Server (NTRS)

Adumitroaie, Virgil; Shelton, Kacie; Elfes, Alberto; Weisbin, Charles R.

2006-01-01

This slide presentation reviews a process of postoptimally analysing the selection of technology portfolios. The rationale for the analysis stems from the need for consistent, transparent and auditable decision making processes and tools. The methodology is used to assure that project investments are selected through an optimization of net mission value. The main intent of the analysis is to gauge the degree of confidence in the optimal solution and to provide the decision maker with an array of viable selection alternatives which take into account input uncertainties and possibly satisfy non-technical constraints. A few examples of the analysis are reviewed. The goal of the postoptimality study is to enhance and improve the decision-making process by providing additional qualifications and substitutes to the optimal solution.

GaAs/Ge Solar Powered Aircraft

NASA Technical Reports Server (NTRS)

Colozza, Anthony J.; Scheiman, David A.; Brinker, David J.

1998-01-01

Unmanned Aerial Vehicles (UAV) are being proposed for many applications for many applications including surveillance, mapping and atmospheric studies. These applications require a lightweight, low speed, medium to long duration aircraft. Due to the weight, speed, and altitude constraints imposed on such an aircraft, solar array generated electric power can be a viable alternative to air-breathing engines for certain missions. Development of such an aircraft is currently being funded under the Environmental Research Aircraft and Sensor Technology (ERAST) program. NASA Lewis Research Center (LeRC) has built a Solar Electric Airplane to demonstrate UAV technology. This aircraft utilizes high efficiency Applied Solar Energy Corporation (ASEC) GaAs/Ge space solar cells. The cells have been provided by the Air Force through the ManTech Office.

Biofuels Fuels Technology Pathway Options for Advanced Drop-in Biofuels Production

DOE Office of Scientific and Technical Information (OSTI.GOV)

Kevin L Kenney

2011-09-01

Advanced drop-in hydrocarbon biofuels require biofuel alternatives for refinery products other than gasoline. Candidate biofuels must have performance characteristics equivalent to conventional petroleum-based fuels. The technology pathways for biofuel alternatives also must be plausible, sustainable (e.g., positive energy balance, environmentally benign, etc.), and demonstrate a reasonable pathway to economic viability and end-user affordability. Viable biofuels technology pathways must address feedstock production and environmental issues through to the fuel or chemical end products. Potential end products include compatible replacement fuel products (e.g., gasoline, diesel, and JP8 and JP5 jet fuel) and other petroleum products or chemicals typically produced from a barrelmore » of crude. Considering the complexity and technology diversity of a complete biofuels supply chain, no single entity or technology provider is capable of addressing in depth all aspects of any given pathway; however, all the necessary expert entities exist. As such, we propose the assembly of a team capable of conducting an in-depth technology pathway options analysis (including sustainability indicators and complete LCA) to identify and define the domestic biofuel pathways for a Green Fleet. This team is not only capable of conducting in-depth analyses on technology pathways, but collectively they are able to trouble shoot and/or engineer solutions that would give industrial technology providers the highest potential for success. Such a team would provide the greatest possible down-side protection for high-risk advanced drop-in biofuels procurement(s).« less

Sweetening Android Lemon Markets: Measuring and Curbing Malware in Application Marketplaces

DTIC Science & Technology

2012-06-08

the main software distribution mechanism for modern mobile devices but are also emerging as a viable alternative to brick -and- mortar stores for...mechanism for modern mobile devices but are also emerging as a viable alternative to brick -and- mortar stores for personal computers. While most...through the Apple App Store , thereby entirely forgoing the traditional distribution channel – packaged opti- cal media sold in brick -and- mortar

Hydrogen production by Cyanobacteria

PubMed Central

Dutta, Debajyoti; De, Debojyoti; Chaudhuri, Surabhi; Bhattacharya, Sanjoy K

2005-01-01

The limited fossil fuel prompts the prospecting of various unconventional energy sources to take over the traditional fossil fuel energy source. In this respect the use of hydrogen gas is an attractive alternate source. Attributed by its numerous advantages including those of environmentally clean, efficiency and renew ability, hydrogen gas is considered to be one of the most desired alternate. Cyanobacteria are highly promising microorganism for hydrogen production. In comparison to the traditional ways of hydrogen production (chemical, photoelectrical), Cyanobacterial hydrogen production is commercially viable. This review highlights the basic biology of cynobacterial hydrogen production, strains involved, large-scale hydrogen production and its future prospects. While integrating the existing knowledge and technology, much future improvement and progress is to be done before hydrogen is accepted as a commercial primary energy source. PMID:16371161

Technology Solutions Case Study: Stud Walls with Continuous Exterior Insulation for Factory Built Housing

DOE Office of Scientific and Technical Information (OSTI.GOV)

None

The Advanced Envelope Research effort will provide factory homebuilders with high performance, cost-effective alternative envelope designs. In the near term, these technologies will play a central role in meeting stringent energy code requirements. For manufactured homes, the thermal requirements, last updated by statute in 1994, will move up to the more rigorous IECC 2012 levels in 2013, the requirements of which are consistent with site built and modular housing. This places added urgency on identifying envelope technologies that the industry can implement in the short timeframe. The primary goal of this research is to develop wall designs that meet themore » thermal requirements based on 2012 IECC standards. Given the affordable nature of manufactured homes, impact on first cost is a major consideration in developing the new envelope technologies. This work is part of a four-phase, multi-year effort. Phase 1 identified seven envelope technologies and provided a preliminary assessment of three selected methods for building high performance wall systems. Phase 2 focused on the development of viable product designs, manufacturing strategies, addressing code and structural issues, and cost analysis of the three selected options. An industry advisory committee helped critique and select the most viable solution to move further in the research — stud walls with continuous exterior insulation. Phase 3, the subject of the current report, focused on the design development of the selected wall concept and explored variations on the use of exterior foam insulation. The scope also included material selection, manufacturing and cost analysis, and prototyping and testing.« less

Innovative Treatment Technologies for Natural Waters and Wastewaters

DOE Office of Scientific and Technical Information (OSTI.GOV)

Childress, Amy E.

2011-07-01

The research described in this report focused on the development of novel membrane contactor processes (in particular, forward osmosis (FO), pressure retarded osmosis (PRO), and membrane distillation (MD)) in low energy desalination and wastewater treatment applications and in renewable energy generation. FO and MD are recently gaining national and international attention as viable, economic alternatives for removal of both established and emerging contaminants from natural and process waters; PRO is gaining worldwide attention as a viable source of renewable energy. The interrelationship of energy and water are at the core of this study. Energy and water are inextricably bound; energymore » usage and production must be considered when evaluating any water treatment process for practical application. Both FO and MD offer the potential for substantial energy and resource savings over conventional treatment processes and PRO offers the potential for renewable energy or energy offsets in desalination. Combination of these novel technologies with each other, with existing technologies (e.g., reverse osmosis (RO)), and with existing renewable energy sources (e.g., salinity gradient solar ponds) may enable much less expensive water production and also potable water production in remote or distributed locations. Two inter-related projects were carried out in this investigation. One focused on membrane bioreactors for wastewater treatment and PRO for renewable energy generation; the other focused on MD driven by a salinity gradient solar pond.« less

High-speed civil transport issues and technology program

NASA Technical Reports Server (NTRS)

Hewett, Marle D.

1992-01-01

A strawman program plan is presented, consisting of technology developments and demonstrations required to support the construction of a high-speed civil transport. The plan includes a compilation of technology issues related to the development of a transport. The issues represent technical areas in which research and development are required to allow airframe manufacturers to pursue an HSCT development. The vast majority of technical issues presented require flight demonstrated and validated solutions before a transport development will be undertaken by the industry. The author believes that NASA is the agency best suited to address flight demonstration issues in a concentrated effort. The new Integrated Test Facility at NASA Dryden Flight Research Facility is considered ideally suited to the task of supporting ground validations of proof-of-concept and prototype system demonstrations before night demonstrations. An elaborate ground hardware-in-the-loop (iron bird) simulation supported in this facility provides a viable alternative to developing an expensive fill-scale prototype transport technology demonstrator. Drygen's SR-71 assets, modified appropriately, are a suitable test-bed for supporting flight demonstrations and validations of certain transport technology solutions. A subscale, manned or unmanned flight demonstrator is suitable for flight validation of transport technology solutions, if appropriate structural similarity relationships can be established. The author contends that developing a full-scale prototype transport technology demonstrator is the best alternative to ensuring that a positive decision to develop a transport is reached by the United States aerospace industry.

Towards quantitative PET/MRI: a review of MR-based attenuation correction techniques.

PubMed

Hofmann, Matthias; Pichler, Bernd; Schölkopf, Bernhard; Beyer, Thomas

2009-03-01

Positron emission tomography (PET) is a fully quantitative technology for imaging metabolic pathways and dynamic processes in vivo. Attenuation correction of raw PET data is a prerequisite for quantification and is typically based on separate transmission measurements. In PET/CT attenuation correction, however, is performed routinely based on the available CT transmission data. Recently, combined PET/magnetic resonance (MR) has been proposed as a viable alternative to PET/CT. Current concepts of PET/MRI do not include CT-like transmission sources and, therefore, alternative methods of PET attenuation correction must be found. This article reviews existing approaches to MR-based attenuation correction (MR-AC). Most groups have proposed MR-AC algorithms for brain PET studies and more recently also for torso PET/MR imaging. Most MR-AC strategies require the use of complementary MR and transmission images, or morphology templates generated from transmission images. We review and discuss these algorithms and point out challenges for using MR-AC in clinical routine. MR-AC is work-in-progress with potentially promising results from a template-based approach applicable to both brain and torso imaging. While efforts are ongoing in making clinically viable MR-AC fully automatic, further studies are required to realize the potential benefits of MR-based motion compensation and partial volume correction of the PET data.

Process to Selectively Distinguish Viable from Non-Viable Bacterial Cells

NASA Technical Reports Server (NTRS)

LaDuc, Myron T.; Bernardini, Jame N.; Stam, Christina N.

2010-01-01

The combination of ethidium monoazide (EMA) and post-fragmentation, randomly primed DNA amplification technologies will enhance the analytical capability to discern viable from non-viable bacterial cells in spacecraft-related samples. Intercalating agents have been widely used since the inception of molecular biology to stain and visualize nucleic acids. Only recently, intercalating agents such as EMA have been exploited to selectively distinguish viable from dead bacterial cells. Intercalating dyes can only penetrate the membranes of dead cells. Once through the membrane and actually inside the cell, they intercalate DNA and, upon photolysis with visible light, produce stable DNA monoadducts. Once the DNA is crosslinked, it becomes insoluble and unable to be fragmented for post-fragmentation, randomly primed DNA library formation. Viable organisms DNA remains unaffected by the intercalating agents, allowing for amplification via post-fragmentation, randomly primed technologies. This results in the ability to carry out downstream nucleic acid-based analyses on viable microbes to the exclusion of all non-viable cells.

Aquatic Plants and Wastewater Treatment (an Overview)

NASA Technical Reports Server (NTRS)

Wolverton, B. C.

1986-01-01

The technology for using water hyacinth to upgrade domestic sewage effluent from lagoons and other wastewater treatment facilities to secondary and advanced secondary standards has been sufficiently developed to be used where the climate is warm year round. The technology of using emergent plants such as bulrush combined with duckweed is also sufficiently developed to make this a viable wastewater treatment alternative. This system is suited for both temperate and semi-tropical areas found throughout most of the U.S. The newest technology in artificial marsh wastewater treatment involves the use of emergent plant roots in conjunction with high surface area rock filters. Smaller land areas are required for these systems because of the increased concentration of microorganisms associated with the rock and plant root surfaces. Approximately 75 percent less land area is required for the plant-rock system than is required for a strict artificial wetland to achieve the same level of treatment.

Algae to Economically Viable Low-Carbon-Footprint Oil.

PubMed

Bhujade, Ramesh; Chidambaram, Mandan; Kumar, Avnish; Sapre, Ajit

2017-06-07

Algal oil as an alternative to fossil fuel has attracted attention since the 1940s, when it was discovered that many microalgae species can produce large amounts of lipids. Economics and energy security were the motivational factors for a spurt in algae research during the 1970s, 1990s, and early 2000s. Whenever crude prices declined, research on algae stopped. The scenario today is different. Even given low and volatile crude prices ($30-$50/barrel), interest in algae continues all over the world. Algae, with their cure-all characteristics, have the potential to provide sustainable solutions to problems in the energy-food-climate nexus. However, after years of effort, there are no signs of algae-to-biofuel technology being commercialized. This article critically reviews past work; summarizes the current status of the technology; and based on the lessons learned, provides a balanced perspective on a potential path toward commercialization of algae-to-oil technology.

Evaluation of alternative snowplowable markers and snowplowing procedures.

DOT National Transportation Integrated Search

2013-06-01

The objectives of this study were to investigate viable alternatives to the currently approved snowplowable raised pavement marker and alternative methods and equipment used to snowplow roadways. The study included evaluating any potential durable an...

On the way to commercializing plant cell culture platform for biopharmaceuticals: present status and prospect.

PubMed

Xu, Jianfeng; Zhang, Ningning

2014-12-01

Plant cell culture is emerging as an alternative bioproduction system for recombinant pharmaceuticals. Growing plant cells in vitro under controlled environmental conditions allows for precise control over cell growth and protein production, batch-to-batch product consistency and a production process aligned with current good manufacturing practices. With the recent US FDA approval and commercialization of the world's first plant cell-based recombinant pharmaceutical for human use, β-glucocerebrosidase for treatment of Gaucher's disease, a new era has come in which plant cell culture shows high potential to displace some established platform technologies in niche markets. This review updates the progress in plant cell culture processing technology, highlights recent commercial successes and discusses the challenges that must be overcome to make this platform commercially viable.

Potential of Aqueous Ozone to Control Aflatoxigenic Fungi in Brazil Nuts

PubMed Central

Morales-Valle, Héctor; Venâncio, Armando

2013-01-01

This study aimed to verify the use of aqueous ozone as alternative technology for fungal control. Brazil nuts sterilized were inoculated with either 1 × 106 or 1 × 107 conidia mL−1 of Aspergillus flavus (MUM 9201) to determine optimal treatment parameters and different aqueous ozone contact times. These assays showed that the effect of ozone is almost immediate against A. flavus, and the optimum ozone concentration depended on the number of initial viable spores on the shell. The remaining viable spores in the ozone solution were recorded, and the rate of inactivation for each treatment was determined by assessing the ratio between the cfu of each treatment and the control. The ozonized nuts were also cultured to recover the fungal population. Aqueous ozone was effective in reducing the conidia of A. flavus and the natural fungal population associated with Brazil nuts. Aqueous ozone presented a great potential to reduce microorganisms counts in Brazil nuts with a great potential use in packing houses for decontamination step. PMID:25937982

Current Impact, Future Prospects and Implications of Mobile Healthcare in India

PubMed Central

Kappal, Rishi; Mehndiratta, Amit; Anandaraj, Prabu; Tsanas, Athanasios

2014-01-01

India has a diverse geographical landscape and predominately rural population. Telemedicine is identified as one of the technological pillars to support healthcare services in this region, but is associated with high cost and complex infrastructure, thus restricting its wider use. Mobile-based healthcare (m-Health) services may provide a practical, promising alternative approach to support healthcare facilities. India has a high mobile user base, both in cities and in rural regions. The appropriate identification of mobile data transmission technology for healthcare services is vital to optimally use the available technology. In this article, we review current telecommunication systemsin India, specifically the evolving consensus on the need for CDMA (Code Division Multiple Access - a wireless technology used by leading international and national operators. This technology is deployed in 800MHz band making it economically viable and far reaching with high quality of services) to continue its operations in India along with mobile healthcare services. We also discuss how healthcare services may be extended using m-Health technologies, given the availability of telecommunications and related services. PMID:29755887

Prostate cancer: cryotherapy.

PubMed

Shinohara, Katsuto

2003-11-01

The incidence of prostate cancer has more than doubled in the last 10 years, and 220,900 new cases will be detected in 2003. This increase is due in large part to increased use of prostate-specific antigen (PSA)-based screening, transrectal ultrasonography, and random biopsy of the prostate. The treatment of prostate cancer, however, remains controversial, and no consensus has been established as to what constitutes appropriate treatment for any stage of disease, especially for localized cancers. Radical prostatectomy, radiation therapy, or watchful waiting all have their advocates, and the risks and benefits of these approaches are discussed frequently. Skepticism about conventional treatments has stimulated patients and physicians to search for alternatives that are effective and associated with limited morbidity. Technologic developments have rekindled interest in cryotherapy as a viable alternative to other, more conventional localized therapies. Given the relative paucity of alternatives for patients who experience biochemical progression after radiotherapy, cryosurgery also may prove to be a good alternative for those patients whose tumors appear to remain localized despite progression. In addition, it appears that cryosurgery will play an increased role in the future management of prostate cancer.

Fuel cells for automotive powertrains-A techno-economic assessment

NASA Astrophysics Data System (ADS)

Mock, Peter; Schmid, Stephan A.

With the objective of identifying the hurdles currently preventing a widespread application of fuel cell technology in passenger cars an assessment of technical and economic parameters is carried out. Patent and publication analysis is used to assess current status of fuel cell technology regarding its position on technology life cycle. S-curve methodology leads to the conclusion that further scientific activity is to be expected but for today's low-temperature PEM fuel cell technology might level by 2015. Technical analysis identifies power density and platinum loading as parameters for which further improvements are necessary in order to satisfy future customer needs. A detailed cost evaluation suggests that in future for high production volumes (approx. 1 million vehicles cumulative) significantly lower costs for fuel cell stacks (12-40 kW -1) and systems (35-83 kW -1) will be viable. Reducing costs to such a level will have to be the main focus for upcoming research activities in order to make fuel cell driven road vehicles a competitive alternative.

Sodium-Oxygen Battery: Steps Toward Reality.

PubMed

Landa-Medrano, Imanol; Li, Chunmei; Ortiz-Vitoriano, Nagore; Ruiz de Larramendi, Idoia; Carrasco, Javier; Rojo, Teófilo

2016-04-07

Rechargeable metal-oxygen batteries are receiving significant interest as a possible alternative to current state of the art lithium ion batteries due to their potential to provide higher gravimetric energies, giving significantly lighter or longer-lasting batteries. Recent advances suggest that the Na-O2 battery, in many ways analogous to Li-O2 yet based on the reversible formation of sodium superoxide (NaO2), has many advantages such as a low charge overpotential (∼100 mV) resulting in improved efficiency. In this Perspective, we discuss the current state of knowledge in Na-O2 battery technology, with an emphasis on the latest experimental studies, as well as theoretical models. We offer special focus on the principle outstanding challenges and issues and address the advantages/disadvantages of the technology when compared with Li-O2 batteries as well as other state-of-the-art battery technologies. We finish by detailing the direction required to make Na-O2 batteries both commercially and technologically viable.

Trends in Nanomaterial-Based Non-Invasive Diabetes Sensing Technologies

PubMed Central

Makaram, Prashanth; Owens, Dawn; Aceros, Juan

2014-01-01

Blood glucose monitoring is considered the gold standard for diabetes diagnostics and self-monitoring. However, the underlying process is invasive and highly uncomfortable for patients. Furthermore, the process must be completed several times a day to successfully manage the disease, which greatly contributes to the massive need for non-invasive monitoring options. Human serums, such as saliva, sweat, breath, urine and tears, contain traces of glucose and are easily accessible. Therefore, they allow minimal to non-invasive glucose monitoring, making them attractive alternatives to blood measurements. Numerous developments regarding noninvasive glucose detection techniques have taken place over the years, but recently, they have gained recognition as viable alternatives, due to the advent of nanotechnology-based sensors. Such sensors are optimal for testing the amount of glucose in serums other than blood thanks to their enhanced sensitivity and selectivity ranges, in addition to their size and compatibility with electronic circuitry. These nanotechnology approaches are rapidly evolving, and new techniques are constantly emerging. Hence, this manuscript aims to review current and future nanomaterial-based technologies utilizing saliva, sweat, breath and tears as a diagnostic medium for diabetes monitoring. PMID:26852676

Trends in Nanomaterial-Based Non-Invasive Diabetes Sensing Technologies.

PubMed

Makaram, Prashanth; Owens, Dawn; Aceros, Juan

2014-04-21

Blood glucose monitoring is considered the gold standard for diabetes diagnostics and self-monitoring. However, the underlying process is invasive and highly uncomfortable for patients. Furthermore, the process must be completed several times a day to successfully manage the disease, which greatly contributes to the massive need for non-invasive monitoring options. Human serums, such as saliva, sweat, breath, urine and tears, contain traces of glucose and are easily accessible. Therefore, they allow minimal to non-invasive glucose monitoring, making them attractive alternatives to blood measurements. Numerous developments regarding noninvasive glucose detection techniques have taken place over the years, but recently, they have gained recognition as viable alternatives, due to the advent of nanotechnology-based sensors. Such sensors are optimal for testing the amount of glucose in serums other than blood thanks to their enhanced sensitivity and selectivity ranges, in addition to their size and compatibility with electronic circuitry. These nanotechnology approaches are rapidly evolving, and new techniques are constantly emerging. Hence, this manuscript aims to review current and future nanomaterial-based technologies utilizing saliva, sweat, breath and tears as a diagnostic medium for diabetes monitoring.

Cobalt: A GPU-based correlator and beamformer for LOFAR

NASA Astrophysics Data System (ADS)

Broekema, P. Chris; Mol, J. Jan David; Nijboer, R.; van Amesfoort, A. S.; Brentjens, M. A.; Loose, G. Marcel; Klijn, W. F. A.; Romein, J. W.

2018-04-01

For low-frequency radio astronomy, software correlation and beamforming on general purpose hardware is a viable alternative to custom designed hardware. LOFAR, a new-generation radio telescope centered in the Netherlands with international stations in Germany, France, Ireland, Poland, Sweden and the UK, has successfully used software real-time processors based on IBM Blue Gene technology since 2004. Since then, developments in technology have allowed us to build a system based on commercial off-the-shelf components that combines the same capabilities with lower operational cost. In this paper, we describe the design and implementation of a GPU-based correlator and beamformer with the same capabilities as the Blue Gene based systems. We focus on the design approach taken, and show the challenges faced in selecting an appropriate system. The design, implementation and verification of the software system show the value of a modern test-driven development approach. Operational experience, based on three years of operations, demonstrates that a general purpose system is a good alternative to the previous supercomputer-based system or custom-designed hardware.

Evaluating the environmental impacts of a nano-enhanced field emission display using life cycle assessment: a screening-level study.

PubMed

Upadhyayula, Venkata K K; Meyer, David E; Curran, Mary Ann; Gonzalez, Michael A

2014-01-21

Carbon nanotube (CNT) field emission displays (FEDs) are currently in the product development stage and are expected to be commercialized in the near future because they offer image quality and viewing angles comparable to a cathode ray tube (CRT) while using a thinner structure, similar to a liquid crystal display (LCD), and enable more efficient power consumption during use. To address concerns regarding the environmental performance of CNT-FEDs, a screening-level, cradle-to-grave life cycle assessment (LCA) was conducted based on a functional unit of 10,000 viewing hours, the viewing lifespan of a CNT-FED. Contribution analysis suggests the impacts for material acquisition and manufacturing are greater than the combined impacts for use and end-of-life. A scenario analysis of the CNT paste composition identifies the metal components used in the paste are key contributors to the impacts of the upstream stages due to the impacts associated with metal preparation. Further improvement of the manufacturing impacts is possible by considering the use of plant-based oils, such as rapeseed oil, as alternatives to organic solvents for dispersion of CNTs. Given the differences in viewing lifespan, the impacts of the CNT-FED were compared with a LCD and a CRT display to provide more insight on how to improve the CNT-FED to make it a viable product alternative. When compared with CRT technology, CNT-FEDs show better environmental performance, whereas a comparison with LCD technology indicates the environmental impacts are roughly the same. Based on the results, the enhanced viewing capabilities of CNT-FEDs will be a more viable display option if manufacturers can increase the product's expected viewing lifespan.

Revisiting Nuclear Thermal Propulsion for Human Mars Exploration

NASA Technical Reports Server (NTRS)

Percy, Thomas K.; Rodriguez, Mitchell

2017-01-01

Nuclear Thermal Propulsion (NTP) has long been considered as a viable in-space transportation alternative for delivering crew and cargo to the Martian system. While technology development work in nuclear propulsion has continued over the year, general interest in NTP propulsion applications has historically been tied directly to the ebb and flow of interest in sending humans to explore Mars. As far back as the 1960’s, plans for NTP-based human Mars exploration have been proposed and periodically revisited having most recently been considered as part of NASA Design Reference Architecture (DRA) 5.0. NASA has been investigating human Mars exploration strategies tied to its current Journey to Mars for the past few years however, NTP has only recently been added into the set of alternatives under consideration for in-space propulsion under the Mars Study Capability (MSC) team, formerly the Evolvable Mars Campaign (EMC) team. The original charter of the EMC was to find viable human Mars exploration approaches that relied heavily on technology investment work already underway, specifically related to the development of large Solar Electric Propulsion (SEP) systems. The EMC team baselined several departures from traditional Mars exploration ground rules to enable these types of architectures. These ground rule changes included lower energy conjunction class trajectories with corresponding longer flight times, aggregation of mission elements in cis-Lunar space rather than Low Earth Orbit (LEO) and, in some cases, the pre-deployment of Earth return propulsion systems to Mars. As the MSC team continues to refine the in-space transportation trades, an NTP-based architecture that takes advantage of some of these ground rule departures is being introduced.

Advanced Envelope Research for Factory Built Housing, Phase 3. Design Development and Prototyping

DOE Office of Scientific and Technical Information (OSTI.GOV)

Levy, E.; Kessler, B.; Mullens, M.

2014-01-01

The Advanced Envelope Research effort will provide factory homebuilders with high performance, cost-effective alternative envelope designs. In the near term, these technologies will play a central role in meeting stringent energy code requirements. For manufactured homes, the thermal requirements, last updated by statute in 1994, will move up to the more rigorous IECC 2012 levels in 2013, the requirements of which are consistent with site built and modular housing. This places added urgency on identifying envelope technologies that the industry can implement in the short timeframe. The primary goal of this research is to develop wall designs that meet themore » thermal requirements based on 2012 IECC standards. Given the affordable nature of manufactured homes, impact on first cost is a major consideration in developing the new envelope technologies. This work is part of a four-phase, multi-year effort. Phase 1 identified seven envelope technologies and provided a preliminary assessment of three selected methods for building high performance wall systems. Phase 2 focused on the development of viable product designs, manufacturing strategies, addressing code and structural issues, and cost analysis of the three selected options. An industry advisory committee helped critique and select the most viable solution to move further in the research -- stud walls with continuous exterior insulation. Phase 3, the subject of the current report, focused on the design development of the selected wall concept and explored variations on the use of exterior foam insulation. The scope also included material selection, manufacturing and cost analysis, and prototyping and testing.« less

Advanced Envelope Research for Factory Built Housing, Phase 3 -- Design Development and Prototyping

DOE Office of Scientific and Technical Information (OSTI.GOV)

Levy, E.; Kessler, B.; Mullens, M.

2014-01-01

The Advanced Envelope Research effort will provide factory homebuilders with high performance, cost-effective alternative envelope designs. In the near term, these technologies will play a central role in meeting stringent energy code requirements. For manufactured homes, the thermal requirements, last updated by statute in 1994, will move up to the more rigorous IECC 2012 levels in 2013, the requirements of which are consistent with site built and modular housing. This places added urgency on identifying envelope technologies that the industry can implement in the short timeframe. The primary goal of this research is to develop wall designs that meet themore » thermal requirements based on 2012 IECC standards. Given the affordable nature of manufactured homes, impact on first cost is a major consideration in developing the new envelope technologies. This work is part of a four-phase, multi-year effort. Phase 1 identified seven envelope technologies and provided a preliminary assessment of three selected methods for building high performance wall systems. Phase 2 focused on the development of viable product designs, manufacturing strategies, addressing code and structural issues, and cost analysis of the three selected options. An industry advisory committee helped critique and select the most viable solution to move further in the research -- stud walls with continuous exterior insulation. Phase 3, the subject of the current report, focused on the design development of the selected wall concept and explored variations on the use of exterior foam insulation. The scope also included material selection, manufacturing and cost analysis, and prototyping and testing.« less

Stud Walls With Continuous Exterior Insulation for Factory Built Housing: New York, New York (Fact Sheet), NREL (National Renewable Energy Laboratory)

DOE Office of Scientific and Technical Information (OSTI.GOV)

None, None

The Advanced Envelope Research effort will provide factory homebuilders with high performance, cost-effective alternative envelope designs. In the near term, these technologies will play a central role in meeting stringent energy code requirements. For manufactured homes, the thermal requirements, last updated by statute in 1994, will move up to the more rigorous IECC 2012 levels in 2013, the requirements of which are consistent with site built and modular housing. This places added urgency on identifying envelope technologies that the industry can implement in the short timeframe. The primary goal of this research is to develop wall designs that meet themore » thermal requirements based on 2012 IECC standards. Given the affordable nature of manufactured homes, impact on first cost is a major consideration in developing the new envelope technologies. This work is part of a four-phase, multi-year effort. Phase 1 identified seven envelope technologies and provided a preliminary assessment of three selected methods for building high performance wall systems. Phase 2 focused on the development of viable product designs, manufacturing strategies, addressing code and structural issues, and cost analysis of the three selected options. An industry advisory committee helped critique and select the most viable solution to move further in the research - stud walls with continuous exterior insulation. Phase 3, the subject of the current report, focused on the design development of the selected wall concept and explored variations on the use of exterior foam insulation. The scope also included material selection, manufacturing and cost analysis, and prototyping and testing.« less

Very high gravity (VHG) ethanolic brewing and fermentation: a research update.

PubMed

Puligundla, Pradeep; Smogrovicova, Daniela; Obulam, Vijaya Sarathi Reddy; Ko, Sanghoon

2011-09-01

There have been numerous developments in ethanol fermentation technology since the beginning of the new millennium as ethanol has become an immediate viable alternative to fast-depleting crude reserves as well as increasing concerns over environmental pollution. Nowadays, although most research efforts are focused on the conversion of cheap cellulosic substrates to ethanol, methods that are cost-competitive with gasoline production are still lacking. At the same time, the ethanol industry has engaged in implementing potential energy-saving, productivity and efficiency-maximizing technologies in existing production methods to become more viable. Very high gravity (VHG) fermentation is an emerging, versatile one among such technologies offering great savings in process water and energy requirements through fermentation of higher concentrations of sugar substrate and, therefore, increased final ethanol concentration in the medium. The technology also allows increased fermentation efficiency, without major alterations to existing facilities, by efficient utilization of fermentor space and elimination of known losses. This comprehensive research update on VHG technology is presented in two main sections, namely VHG brewing, wherein the effects of nutrients supplementation, yeast pitching rate, flavour compound synthesis and foam stability under increased wort gravities are discussed; and VHG bioethanol fermentation studies. In the latter section, aspects related to the role of osmoprotectants and nutrients in yeast stress reduction, substrates utilized/tested so far, including saccharide (glucose, sucrose, molasses, etc.) and starchy materials (wheat, corn, barley, oats, etc.), and mash viscosity issues in VHG bioethanol production are detailed. Thereafter, topics common to both areas such as process optimization studies, mutants and gene level studies, immobilized yeast applications, temperature effect, reserve carbohydrates profile in yeast, and economic aspects are discussed and future prospects are summarized.

Evaluation of the BioVigilant IMD-A, a novel optical spectroscopy technology for the continuous and real-time environmental monitoring of viable and nonviable particles. Part II. Case studies in environmental monitoring during aseptic filling, intervention assessments, and glove integrity testing in manufacturing isolators.

PubMed

Miller, Michael J; Walsh, Michael R; Shrake, Jerry L; Dukes, Randall E; Hill, Daniel B

2009-01-01

This paper describes the use of the BioVigilant IMD-A, a real-time and continuous monitoring technology based on optical spectroscopy, to simultaneously and instantaneously detect, size, and enumerate both viable and nonviable particles in a variety of filling and transfer isolator environments during an aseptic fill, transfer of sterilized components, and filling interventions. Continuous monitoring of three separate isolators for more than 16 h and representing more than 28 m3 of air per isolator (under static conditions) yielded a mean viable particle count of zero (0) per cubic meter. Although the mean count per cubic meter was zero, the detection of very low levels of single viable particles was randomly observed in each of these sampling runs. No viable particles were detected during the manual transfer of sterilized components from transfer isolators into a filling isolator, and similar results were observed during an aseptic fill, a filling needle change-out procedure, and during disassembly, movement, and reassembly of a vibrating stopper bowl. During the continuous monitoring of a sample transfer port and a simulated mousehole, no viable particles were detected; however, when the sampling probe was inserted beyond the isolator-room interface, the IMD-A instantaneously detected and enumerated both viable and nonviable particles originating from the surrounding room. Data from glove pinhole studies showed no viable particles being observed, although significant viable particles were immediately detected when the gloves were removed and a bare hand was allowed to introduce microorganisms into the isolator. The IMD-A technology offers the industry an unprecedented advantage over growth-based bioaerosol samplers for monitoring the state of microbiological control in pharmaceutical manufacturing environments, and represents significant progress toward the acceptance of microbiology process analytical technology solutions for the industry.

Space Solar Power Demonstrations: Challenges and Progress

NASA Technical Reports Server (NTRS)

Howell, Joe T.; Mankins, John C.; Lavoie, Anthony R. (Technical Monitor)

2002-01-01

The prospects of using electrical power beamed from space are coming closer to reality with the continued pursuit and improvements in the supporting space solar research and technology. Space Solar Power (SSP) has been explored off and on for approximately three decades as a viable alternative and clean energy source. Results produced through the more recent Space Solar Power Exploratory Research and Technology (SERT) program involving extensive participation by industry, universities, and government has provided a sound technical basis for believing that technology can be improved to the extent that SSP systems can be built, economically feasible, and successfully deployed in space. Considerable advancements have been made in conceptual designs and supporting technologies including solar power generation, wireless power transmission, power management distribution, thermal management and materials, and the integrated systems engineering assessments. Basic technologies have progressed to the point were the next logical step is to formulate and conduct sophisticated demonstrations involving prototype hardware as final proof of concepts and identify high end technology readiness levels in preparation for full scale SSP systems designs. In addition to continued technical development issues, environmental and safety issues must be addressed and appropriate actions taken to reassure the public and prepare them for the future use of this alternative renewable energy resource. Accomplishing these objectives will allow informed future decisions regarding further SSP and related R&D investments by both NASA management and prospective external partners. In particular, accomplishing these objectives will also guide further definition of SSP and related technology roadmaps including performance objectives, resources and schedules; including 'multi-purpose' applications (terrestrial markets, science, commercial development of space, and other government missions).

The heavy-duty vehicle future in the United States: A parametric analysis of technology and policy tradeoffs

DOE PAGES

Askin, Amanda Christine; Barter, Garrett; West, Todd H.; ...

2015-02-14

Here, we present a parametric analysis of factors that can influence advanced fuel and technology deployments in U.S. Class 7–8 trucks through 2050. The analysis focuses on the competition between traditional diesel trucks, natural gas vehicles (NGVs), and ultra-efficient powertrains. Underlying the study is a vehicle choice and stock model of the U.S. heavy-duty vehicle market. Moreover, the model is segmented by vehicle class, body type, powertrain, fleet size, and operational type. We find that conventional diesel trucks will dominate the market through 2050, but NGVs could have significant market penetration depending on key technological and economic uncertainties. Compressed naturalmore » gas trucks conducting urban trips in fleets that can support private infrastructure are economically viable now and will continue to gain market share. Ultra-efficient diesel trucks, exemplified by the U.S. Department of Energy's SuperTruck program, are the preferred alternative in the long haul segment, but could compete with liquefied natural gas (LNG) trucks if the fuel price differential between LNG and diesel increases. However, the greatest impact in reducing petroleum consumption and pollutant emissions is had by investing in efficiency technologies that benefit all powertrains, especially the conventional diesels that comprise the majority of the stock, instead of incentivizing specific alternatives.« less

PMA-PhyloChip DNA Microarray to Elucidate Viable Microbial Community Structure

NASA Technical Reports Server (NTRS)

Venkateswaran, Kasthuri J.; Stam, Christina N.; Andersen, Gary L.; DeSantis, Todd

2011-01-01

Since the Viking missions in the mid-1970s, traditional culture-based methods have been used for microbial enumeration by various NASA programs. Viable microbes are of particular concern for spacecraft cleanliness, for forward contamination of extraterrestrial bodies (proliferation of microbes), and for crew health/safety (viable pathogenic microbes). However, a "true" estimation of viable microbial population and differentiation from their dead cells using the most sensitive molecular methods is a challenge, because of the stability of DNA from dead cells. The goal of this research is to evaluate a rapid and sensitive microbial detection concept that will selectively estimate viable microbes. Nucleic acid amplification approaches such as the polymerase chain reaction (PCR) have shown promise for reducing time to detection for a wide range of applications. The proposed method is based on the use of a fluorescent DNA intercalating agent, propidium monoazide (PMA), which can only penetrate the membrane of dead cells. The PMA-quenched reaction mixtures can be screened, where only the DNA from live cells will be available for subsequent PCR reaction and microarray detection, and be identified as part of the viable microbial community. An additional advantage of the proposed rapid method is that it will detect viable microbes and differentiate from dead cells in only a few hours, as opposed to less comprehensive culture-based assays, which take days to complete. This novel combination approach is called the PMA-Microarray method. DNA intercalating agents such as PMA have previously been used to selectively distinguish between viable and dead bacterial cells. Once in the cell, the dye intercalates with the DNA and, upon photolysis under visible light, produces stable DNA adducts. DNA cross-linked in this way is unavailable for PCR. Environmental samples suspected of containing a mixture of live and dead microbial cells/spores will be treated with PMA, and then incubated in the dark. Thereafter, the sample is exposed to visible light for five minutes, so that the DNA from dead cells will be cross-linked. Following this PMA treatment step, the sample is concentrated by centrifugation and washed (to remove excessive PMA) before DNA is extracted. The 16S rRNA gene fragments will be amplified by PCR to screen the total microbial community using PhyloChip DNA microarray analysis. This approach will detect only the viable microbial community since the PMA intercalated DNA from dead cells would be unavailable for PCR amplification. The total detection time including PCR reaction for low biomass samples will be a few hours. Numerous markets may use this technology. The food industry uses spore detection to validate new alternative food processing technologies, sterility, and quality. Pharmaceutical and medical equipment companies also detect spores as a marker for sterility. This system can be used for validating sterilization processes, water treatment systems, and in various public health and homeland security applications.

Should Live Patient Licensing Examinations in Dentistry Be Discontinued? Two Viewpoints: Viewpoint 1: Alternative Assessment Models Are Not Yet Viable Replacements for Live Patients in Clinical Licensure Exams and Viewpoint 2: Ethical and Patient Care Concerns About Live Patient Exams Require Full Acceptance of Justifiable Alternatives.

PubMed

Chu, Tien-Min Gabriel; Makhoul, Nicholas M; Silva, Daniela Rodrigues; Gonzales, Theresa S; Letra, Ariadne; Mays, Keith A

2018-03-01

This Point/Counterpoint article addresses a long-standing but still-unresolved debate on the advantages and disadvantages of using live patients in dental licensure exams. Two contrasting viewpoints are presented. Viewpoint 1 supports the traditional use of live patients, arguing that other assessment models have not yet been demonstrated to be viable alternatives to the actual treatment of patients in the clinical licensure process. This viewpoint also contends that the use of live patients and inherent variances in live patient treatment represent the realities of daily private practice. Viewpoint 2 argues that the use of live patients in licensure exams needs to be discontinued considering those exams' ethical dilemmas of exposing patients to potential harm, as well as their lack of reliability and validity and limited scope. According to this viewpoint, the current presence of viable alternatives means that the risk of harm inherent in live patient exams can finally be eliminated and those exams replaced with other means to confirm that candidates are qualified for licensure to practice.

Alternative approaches to providing passenger transportation in low density cities : the case of Council Bluffs, Iowa

DOT National Transportation Integrated Search

1997-09-01

This study explores transportation alternatives for Council Bluffs. The intention is to explore alternatives that may potentially prove viable for other small cities faced with scattered development patterns and limited population density. The study ...

A review on technological options of waste to energy for effective management of municipal solid waste.

PubMed

Kumar, Atul; Samadder, S R

2017-11-01

Approximately one-fourth population across the world rely on traditional fuels (kerosene, natural gas, biomass residue, firewood, coal, animal dung, etc.) for domestic use despite significant socioeconomic and technological development. Fossil fuel reserves are being exploited at a very fast rate to meet the increasing energy demands, so there is a need to find alternative sources of energy before all the fossil fuel reserves are depleted. Waste to energy (WTE) can be considered as a potential alternative source of energy, which is economically viable and environmentally sustainable. The present study reviewed the current global scenario of WTE technological options (incineration, pyrolysis, gasification, anaerobic digestion, and landfilling with gas recovery) for effective energy recovery and the challenges faced by developed and developing countries. This review will provide a framework for evaluating WTE technological options based on case studies of developed and developing countries. Unsanitary landfilling is the most commonly practiced waste disposal option in the developing countries. However, developed countries have realised the potential of WTE technologies for effective municipal solid waste management (MSWM). This review will help the policy makers and the implementing authorities involved in MSWM to understand the current status, challenges and barriers for effective management of municipal solid waste. This review concluded WTE as a potential renewable source of energy, which will partly meet the energy demand and ensure effective MSWM. Copyright © 2017 Elsevier Ltd. All rights reserved.

Economically viable biochemical processes for the advanced rural biorefinery and downstream recovery operations

USDA-ARS?s Scientific Manuscript database

Rural biorefineries offer an alternative to traditional ethanol production by providing the opportunity to produce fuel on site to reduce costs associated with biomass transportation thus making the fuel economically viable. Widespread installation of rural biorefineries could lead to increased upt...

Design of a GaAs/Ge Solar Array for Unmanned Aerial Vehicles

NASA Technical Reports Server (NTRS)

Scheiman, David A.; Brinker, David J.; Bents, David J.; Colozza, Anthony J.

1995-01-01

Unmanned Aerial Vehicles (UAV) are being proposed for many applications including surveillance, mapping and atmospheric studies. These applications require a lightweight, low speed, medium to long duration airplane. Due to the weight, speed, and altitude constraints imposed on such aircraft, solar array generated electric power is a viable alternative to air-breathing engines. Development of such aircraft is currently being funded under the Environmental Research Aircraft and Sensor Technology (ERAST) program. NASA Lewis Research Center (LeRC) is currently building a Solar Electric Airplane to demonstrate UAV technology. This aircraft utilizes high efficiency Applied Solar Energy Corporation (ASEC) GaAs/Ge space solar cells. The cells have been provided by the Air Force through the ManTech Office. Expected completion of the plane is early 1995, with the airplane currently undergoing flight testing using battery power.

Design of a GaAs/Ge solar array for unmanned aerial vehicles

NASA Astrophysics Data System (ADS)

Scheiman, David A.; Brinker, David J.; Bents, David J.; Colozza, Anthony J.

1995-03-01

Unmanned Aerial Vehicles (UAV) are being proposed for many applications including surveillance, mapping and atmospheric studies. These applications require a lightweight, low speed, medium to long duration airplane. Due to the weight, speed, and altitude constraints imposed on such aircraft, solar array generated electric power is a viable alternative to air-breathing engines. Development of such aircraft is currently being funded under the Environmental Research Aircraft and Sensor Technology (ERAST) program. NASA Lewis Research Center (LeRC) is currently building a Solar Electric Airplane to demonstrate UAV technology. This aircraft utilizes high efficiency Applied Solar Energy Corporation (ASEC) GaAs/Ge space solar cells. The cells have been provided by the Air Force through the ManTech Office. Expected completion of the plane is early 1995, with the airplane currently undergoing flight testing using battery power.

On the way to commercializing plant cell culture platform for biopharmaceuticals: present status and prospect

PubMed Central

Xu, Jianfeng; Zhang, Ningning

2014-01-01

Plant cell culture is emerging as an alternative bioproduction system for recombinant pharmaceuticals. Growing plant cells in vitro under controlled environmental conditions allows for precise control over cell growth and protein production, batch-to-batch product consistency and a production process aligned with current good manufacturing practices. With the recent US FDA approval and commercialization of the world’s first plant cell-based recombinant pharmaceutical for human use, β-glucocerebrosidase for treatment of Gaucher’s disease, a new era has come in which plant cell culture shows high potential to displace some established platform technologies in niche markets. This review updates the progress in plant cell culture processing technology, highlights recent commercial successes and discusses the challenges that must be overcome to make this platform commercially viable. PMID:25621170

Heterologous surface display on lactic acid bacteria: non-GMO alternative?

PubMed Central

Zadravec, Petra; Štrukelj, Borut; Berlec, Aleš

2015-01-01

Lactic acid bacteria (LAB) are food-grade hosts for surface display with potential applications in food and therapy. Alternative approaches to surface display on LAB would avoid the use of recombinant DNA technology and genetically-modified organism (GMO)-related regulatory requirements. Non-covalent surface display of proteins can be achieved by fusing them to various cell-wall binding domains, of which the Lysine motif domain (LysM) is particularly well studied. Fusion proteins have been isolated from recombinant bacteria or from their growth medium and displayed on unmodified bacteria, enabling heterologous surface display. This was demonstrated on non-viable cells devoid of protein content, termed bacteria-like particles, and on various species of genus Lactobacillus. Of the latter, Lactobacillus salivarius ATCC 11741 was recently shown to be particularly amenable for LysM-mediated display. Possible regulatory implications of heterologous surface display are discussed, particularly those relevant for the European Union. PMID:25880164

Tethered orbital refueling study

NASA Technical Reports Server (NTRS)

Fester, Dale A.; Rudolph, L. Kevin; Kiefel, Erlinda R.; Abbott, Peter W.; Grossrode, Pat

1986-01-01

One of the major applications of the space station will be to act as a refueling depot for cryogenic-fueled space-based orbital transfer vehicles (OTV), Earth-storable fueled orbit maneuvering vehicles, and refurbishable satellite spacecraft using hydrazine. One alternative for fuel storage at the space station is a tethered orbital refueling facility (TORF), separated from the space station by a sufficient distance to induce a gravity gradient force that settles the stored fuels. The technical feasibility was examined with the primary focus on the refueling of LO2/LH2 orbital transfer vehicles. Also examined was the tethered facility on the space station. It was compared to a zero-gravity facility. A tethered refueling facility should be considered as a viable alternative to a zero-gravity facility if the zero-gravity fluid transfer technology, such as the propellant management device and no vent fill, proves to be difficult to develop with the required performance.

Heterologous surface display on lactic acid bacteria: non-GMO alternative?

PubMed

Zadravec, Petra; Štrukelj, Borut; Berlec, Aleš

2015-01-01

Lactic acid bacteria (LAB) are food-grade hosts for surface display with potential applications in food and therapy. Alternative approaches to surface display on LAB would avoid the use of recombinant DNA technology and genetically-modified organism (GMO)-related regulatory requirements. Non-covalent surface display of proteins can be achieved by fusing them to various cell-wall binding domains, of which the Lysine motif domain (LysM) is particularly well studied. Fusion proteins have been isolated from recombinant bacteria or from their growth medium and displayed on unmodified bacteria, enabling heterologous surface display. This was demonstrated on non-viable cells devoid of protein content, termed bacteria-like particles, and on various species of genus Lactobacillus. Of the latter, Lactobacillus salivarius ATCC 11741 was recently shown to be particularly amenable for LysM-mediated display. Possible regulatory implications of heterologous surface display are discussed, particularly those relevant for the European Union.

¡VAMOS! (Viable Alternative Mine Operating System) - a 'Horizon 2020' project

NASA Astrophysics Data System (ADS)

Sword, Cameron; Bodo, Balazs; Kapusniak, Stef; Bosman, Frank; Rainbird, Jenny; Silva, Eduardo

2017-04-01

The 42-month ¡VAMOS! project (Viable Alternative Mine Operating System, Grant Agreement 642477, www.vamos-project.eu), funded by the EC H2020 Programme, will enable access to high-grade EU reserves of mineral ore-bodies by developing an innovative clean and low visibility mining technique. The project will demonstrate the technological and economic viability of the underwater extraction of metallic mineral deposits which are currently technologically, economically, and environmentally unobtainable. In doing so, ¡VAMOS! hopes to encourage investment in abandoned open-pit mines and prospective mines, helping to put the EU back on a level playing field with the rest of the world in terms of access to strategically important minerals. The ¡VAMOS! concept is defined by a remotely-operated underwater mining vehicle, adapted and improved from existing subsea mining technology. Operating in tandem with an HROV, the mining vehicle will connect to a flexible riser through which slurried mined material will be pumped from the mudline to onshore dewatering facilities via a floating mobile deployment-module, on which will be fitted a bypass system linked to an LIBS, allowing real-time grade-control. Analysis of European and national regulation and stakeholder assessments found there is significant support for developing the technology among local communities and governments. An initial environmental assessment of the potential impact of the innovative mining operation concluded the project has a smaller environmental footprint than conventional mining operations: this is due to factors including the quieter operation and absence of blasting, zero water-table flux, and the higher stripping ratio enabled by higher fluid pressure acting on the sidewalls of the mine. The prototypes are currently in their construction phase following a final design freeze in October 2016. Work is now underway on the foresight visioning, economic evaluation and policy guidelines for the ¡VAMOS! methodology and technologies; the project team will be identifying key areas of research interest and assessing the micro and macroeconomic impact of ¡VAMOS!. The deadline for the completion of the underwater mining vehicle prototype is May 2017, and the HROV hardware and software is to be completed by July 2017. Site-tests will take place in the months after the build completion at a number of unique abandoned mines across Europe, with final proof of operational viability due by November 2017.

Economic and environmental analysis of standard, high efficiency, rainwater flushed, and composting toilets.

PubMed

Anand, C; Apul, D S

2011-03-01

The current sanitation technology in developed countries is based on diluting human excreta with large volumes of centrally provided potable water. This approach is a poor use of water resources and is also inefficient, expensive, and energy intensive. The goal of this study was to compare the standard sanitation technology (Scenario 1) with alternative technologies that require less or no potable water use in toilets. The alternative technologies considered were high efficiency toilets flushed with potable water (Scenario 2), standard toilets flushed with rainwater (Scenario 3), high efficiency toilets flushed with rainwater (Scenario 4), and composting toilets (Scenario 5). Cost, energy, and carbon implications of these five design scenarios were studied using two existing University of Toledo buildings. The results showed that alternative systems modeled in Scenarios 2, 4, and 5 were viable options both from an investment and an environmental performance perspective. High efficiency fixtures that use potable water (Scenario 2) is often the most preferred method in high efficiency buildings due to reduced water use and associated reductions in annual water and wastewater costs. However, the cost, energy, and CO(2)EE analyses all showed that Scenarios 4 and 5 were preferable over Scenario 2. Cost payback periods of scenarios 2, 4 and 5 were less than 10 years; in the future, increase in water and wastewater services would further decrease the payback periods. The centralized water and wastewater services have high carbon footprints; therefore if carbon footprint reduction is a primary goal of a building complex, alternative technologies that require less potable water and generate less wastewater can largely reduce the carbon footprint. High efficiency fixtures flushed with rainwater (Scenario 4) and composting toilets (Scenario 5) required considerably less energy than direct energy demands of buildings. However, the annual carbon footprint of these technologies was comparable to the annual carbon footprint from space heating. Similarly, the carbon savings that could be achieved from Scenario 4 or 5 were comparable to a recycling program that can be implemented in buildings. Copyright © 2010 Elsevier Ltd. All rights reserved.

Rapid cell separation with minimal manipulation for autologous cell therapies

NASA Astrophysics Data System (ADS)

Smith, Alban J.; O'Rorke, Richard D.; Kale, Akshay; Rimsa, Roberts; Tomlinson, Matthew J.; Kirkham, Jennifer; Davies, A. Giles; Wälti, Christoph; Wood, Christopher D.

2017-02-01

The ability to isolate specific, viable cell populations from mixed ensembles with minimal manipulation and within intra-operative time would provide significant advantages for autologous, cell-based therapies in regenerative medicine. Current cell-enrichment technologies are either slow, lack specificity and/or require labelling. Thus a rapid, label-free separation technology that does not affect cell functionality, viability or phenotype is highly desirable. Here, we demonstrate separation of viable from non-viable human stromal cells using remote dielectrophoresis, in which an electric field is coupled into a microfluidic channel using shear-horizontal surface acoustic waves, producing an array of virtual electrodes within the channel. This allows high-throughput dielectrophoretic cell separation in high conductivity, physiological-like fluids, overcoming the limitations of conventional dielectrophoresis. We demonstrate viable/non-viable separation efficacy of >98% in pre-purified mesenchymal stromal cells, extracted from human dental pulp, with no adverse effects on cell viability, or on their subsequent osteogenic capabilities.

DE-FOA-EE0005502 Advanced Percussive Drilling Technology for Geothermal Exploration and Development Phase II Report.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Su, Jiann-Cherng; Raymond, David W.; Prasad, Somuri V.

Percussive hammers are a promising advance in drilling technology for geothermal since they rely upon rock reduction mechanisms that are well-suited for use in the hard, brittle rock characteristic of geothermal formations. The project research approach and work plan includes a critical path to development of a high-temperature (HT) percussive hammer using a two- phase approach. The work completed in Phase I of the project demonstrated the viability of percussive hammers and that solutions to technical challenges in design, material technology, and performance are likely to be resolved. Work completed in Phase II focused on testing the findings from Phasemore » I and evaluating performance of the materials and designs at high- operating temperatures. A high-operating temperature (HOT) drilling facility was designed, built, and used to test the performance of the DTH under extreme conditions. Results from the testing indicate that a high-temperature capable hammer can be developed and is a viable alternative for user in the driller's toolbox.« less

Advanced Percussive Drilling Technology for Geothermal Exploration and Development

DOE Office of Scientific and Technical Information (OSTI.GOV)

Su, Jiann; Raymond, David; Prasad, Somuri

Percussive hammers are a promising advance in drilling technology for geothermal since they rely upon rock reduction mechanisms that are well-suited for use in the hard, brittle rock characteristic of geothermal formations. The project research approach and work plan includes a critical path to development of a high-temperature (HT) percussive hammer using a two phase approach. The work completed in Phase I of the project demonstrated the viability of percussive hammers and that solutions to technical challenges in design, material technology, and performance are likely to be resolved. Work completed in Phase II focused on testing the findings from Phasemore » I and evaluating performance of the materials and designs at high operating temperatures. A high-operating temperature (HOT) drilling facility was designed, built, and used to test the performance of the DTH under extreme conditions. Results from the testing indicate that a high-temperature capable hammer can be developed and is a viable alternative for use in the driller’s toolbox.« less

Needle-free and microneedle drug delivery in children: a case for disease-modifying antirheumatic drugs (DMARDs).

PubMed

Shah, Utpal U; Roberts, Matthew; Orlu Gul, Mine; Tuleu, Catherine; Beresford, Michael W

2011-09-15

Parenteral routes of drug administration have poor acceptability and tolerability in children. Advances in transdermal drug delivery provide a potential alternative for improving drug administration in this patient group. Issues with parenteral delivery in children are highlighted and thus illustrate the scope for the application of needle-free and microneedle technologies. This mini-review discusses the opportunities and challenges for providing disease-modifying antirheumatic drugs (DMARDs) currently prescribed to paediatric rheumatology patients using such technologies. The aim is to raise further awareness of the need for age-appropriate formulations and drug delivery systems and stimulate exploration of these options for DMARDs, and in particular, rapidly emerging biologics on the market. The ability of needle-free and microneedle technologies to deliver monoclonal antibodies and fusion proteins still remains largely untested. Such an understanding is crucial for future drug design opportunities. The bioavailability, safety and tolerance of delivering biologics into the viable epidermis also need to be studied. Copyright © 2011 Elsevier B.V. All rights reserved.

On- and off-grid operation of hybrid renewable power plants: When are the economics favorable?

NASA Astrophysics Data System (ADS)

Petrakopoulou, F.; Santana, D.

2016-12-01

Hybrid renewable energy conversion systems offer a good alternative to conventional systems in locations where the extension of the electrical grid is difficult or not economical or where the cost of electricity is high. However, stand-alone operation implies net energy output restrictions (limited to exclusively serve the energy demand of a region), capacity oversizing and large storage facilities. In interconnected areas, on the other hand, the operational restrictions of the power stations change significantly and the efficiencies and costs of renewable technologies become more favorable. In this paper, the operation of three main renewable technologies (CSP, PV and wind) is studied assuming both hybrid and individual operation for both autonomous and inter-connected operation. The case study used is a Mediterranean island of ca. 3,000 inhabitants. Each system is optimized to fully cover the energy demand of the community. In addition, in the on-grid operation cases, it is required that the annual energy generated from the renewable sources is net positive (i.e., the island generates at least as much energy as it uses). It is found that when connected to the grid, hybridization of more than one technology is not required to satisfy the energy demand, as expected. Each of the renewable technologies investigated can satisfy the annual energy demand individually, without significant complications. In addition, the cost of electricity generated with the three studied technologies drops significantly for on-grid applications, when compared to off-grid operation. However, when compared to business-as-usual scenarios in both the on- and off-grid cases, both investigated hybrid and single-technology renewable scenarios are found to be economically viable. A sensitivity analysis reveals the limits of the acceptable costs that make the technologies favorable when compared to conventional alternatives.

Will CNG threaten your future loads

DOE Office of Scientific and Technical Information (OSTI.GOV)

Not Available

A campaign to promote the use of natural gas as a fleet fuel is described and as a result, CNG conversions are beginning to take hold in some market segments. Only a few months after Ford Motor Co. announced production plans for an LPG-powered line of Granada/Cougar models, it unveiled an alternative-fuels concept car - a short-ranged metro sportscar - that could be ordered by the customer with any of four fuel systems (CNG, propane, ethanol, or methanol) offered on a dedicated or single-fuel basis. By including CNG in its alternative-fuels concept, Ford not only gave a boost to effortsmore » to build a motor fuel load for natural gas, but also indicated that CNG, as well as propane, is a viable alternative to gasoline in some applications. Recent reports of advances in CNG technology that enhance its potential as a motor fuel - together with other reports of at least one US firm launching production of a CNG motor fuel system and of several companies already marketing them - might be cause for the LPG industry to take another look at CNG's competitive potential.« less

Evaluation of an Aircraft Concept With Over-Wing, Hydrogen-Fueled Engines for Reduced Noise and Emissions

NASA Technical Reports Server (NTRS)

Guynn, Mark D.; Olson, Erik D.

2002-01-01

This report describes the analytical modeling and evaluation of an unconventional commercial transport aircraft concept designed to address aircraft noise and emission issues. A strut-braced wing configuration with overwing, ultra-high bypass ratio, hydrogen fueled turbofan engines is considered. Estimated noise and emission characteristics are compared to a conventional configuration designed for the same mission and significant benefits are identified. The design challenges and technology issues which would have to be addressed to make the concept a viable alternative to current aircraft designs are discussed. This concept is one of the "Quiet Green Transport" aircraft concepts studied as part of NASA's Revolutionary Aerospace Systems Concepts (RASC) Program. The RASC Program seeks to develop revolutionary concepts that address strategic objectives of the NASA Enterprises, such as reducing aircraft noise and emissions, and to identify enabling advanced technology requirements for the concepts.

Nanoscale perspective: Materials designs and understandings in lithium metal anodes

DOE Office of Scientific and Technical Information (OSTI.GOV)

Lin, Dingchang; Liu, Yayuan; Pei, Allen

Li metal chemistry is a promising alternative with a much higher energy density than that of state-of-the-art Li-ion counterparts. However, significant challenges including safety issues and poor cyclability have severely impeded Li metal technology from becoming viable. In recent years, nanotechnologies have become increasingly important in materials design and fabrication for Li metal anodes, contributing to major progress in the field. In this review, we first introduce the main achievements in Li metal battery systems fulfilled by nanotechnologies, particularly regarding Li metal anode design and protection, ultrastrong separator engineering, safety monitoring, and smart functions. Next, we introduce recent studies onmore » nanoscale Li nucleation/deposition. Lastly, we discuss possible future research directions. We hope this review delivers an overall picture of the role of nanoscale approaches in the recent progress of Li metal battery technology and inspires more research in the future.« less

NB-PLC channel modelling with cyclostationary noise addition & OFDM implementation for smart grid

NASA Astrophysics Data System (ADS)

Thomas, Togis; Gupta, K. K.

2016-03-01

Power line communication (PLC) technology can be a viable solution for the future ubiquitous networks because it provides a cheaper alternative to other wired technology currently being used for communication. In smart grid Power Line Communication (PLC) is used to support communication with low rate on low voltage (LV) distribution network. In this paper, we propose the channel modelling of narrowband (NB) PLC in the frequency range 5 KHz to 500 KHz by using ABCD parameter with cyclostationary noise addition. Behaviour of the channel was studied by the addition of 11KV/230V transformer, by varying load location and load. Bit error rate (BER) Vs signal to noise ratio SNR) was plotted for the proposed model by employing OFDM. Our simulation results based on the proposed channel model show an acceptable performance in terms of bit error rate versus signal to noise ratio, which enables communication required for smart grid applications.

Nanoscale perspective: Materials designs and understandings in lithium metal anodes

DOE PAGES

Lin, Dingchang; Liu, Yayuan; Pei, Allen; ...

2017-05-19

Li metal chemistry is a promising alternative with a much higher energy density than that of state-of-the-art Li-ion counterparts. However, significant challenges including safety issues and poor cyclability have severely impeded Li metal technology from becoming viable. In recent years, nanotechnologies have become increasingly important in materials design and fabrication for Li metal anodes, contributing to major progress in the field. In this review, we first introduce the main achievements in Li metal battery systems fulfilled by nanotechnologies, particularly regarding Li metal anode design and protection, ultrastrong separator engineering, safety monitoring, and smart functions. Next, we introduce recent studies onmore » nanoscale Li nucleation/deposition. Lastly, we discuss possible future research directions. We hope this review delivers an overall picture of the role of nanoscale approaches in the recent progress of Li metal battery technology and inspires more research in the future.« less

Nano-Filament Field Emission Cathode Development Final Report CRADA No. TSB-0731-93

DOE Office of Scientific and Technical Information (OSTI.GOV)

Bernhardt, Tony; Fahlen, Ted

At the time the CRADA was established, Silicon Video Corporation, of Cupertino, CA was a one-year-old rapidly growing start-up company. SVC was developing flat panel displays (FPDs) to replace Cathode Ray Terminals (CRTs) for personal computers, work stations and televisions. They planned to base their products on low cost and energy efficient field emission technology. It was universally recognized that the display was both the dominant cost item and differentiating feature of many products such as laptop computers and hand-held electronics and that control of the display technology through U.S. sources was essential to success in these markets. The purposemore » of this CRADA project was to determine if electrochemical planarization would be a viable, inexpensive alternative to current optical polishing techniques for planarizing the surface of a ceramic backplate of a thin film display.« less

Advances in Lasers for the Treatment of Stones-a Systematic Review.

PubMed

Kronenberg, Peter; Somani, Bhaskar

2018-05-17

Laser lithotripsy is increasingly used worldwide and is a continuously evolving field with new and extensive research being published every year. Variable pulse length Ho:YAG lithotripters allow new lithotripsy parameters to be manipulated, and there is an effort to integrate new technologies into lithotripters. Pulsed thulium lasers seem to be a viable alternative to holmium lasers. The performance of similar laser fibers varies from manufacturer to manufacturer. Special laser fibers and "cleaving only" fiber tip preparation can be beneficial for the lithotripsy procedure. Different laser settings and the surgical technique employed can have significant impact on the success of laser lithotripsy. When safely done, complications of laser lithotripsy are rare and concern the endoscopic nature of procedure, not the technology itself, making laser lithotripsy one of the safest tools in urology. Laser lithotripsy has had several new developments and more insight has been gained in recent years with many more advances expected in the future.

Industrial pollution prevention programs in selected developing Asian countries

DOE Office of Scientific and Technical Information (OSTI.GOV)

Chiu, Shen-yann

1995-12-31

This paper presents the information on current activities to promote industrial pollution prevention (P2) in five selected Asian economies including Hong Kong, Republic of Korea, the Philippines, ROC in Taiwan, and Thailand. These activities, generally initiated in the last 5 years, are classified into 6 categories: awareness promotion, education and training, information transfer, technology development an demonstration, technical assistance, and financial incentives. Although participation is voluntary, these programs are all important at the early stages of P2 promotion and should be useful in informing industries of the benefit of P2 and helping them identify specific P2 measures as viable environmentalmore » management alternatives.« less

Effects of FAME biodiesel and HVORD on emissions from an older-technology diesel engine.

PubMed

Bugarski, A D; Hummer, J A; Vanderslice, S E

2017-12-01

The results of laboratory evaluations were used to compare the potential of two alternative, biomass-derived fuels as a control strategy to reduce the exposure of underground miners to aerosols and gases emitted by diesel-powered equipment. The effects of fatty acid methyl ester (FAME) biodiesel and hydrotreated vegetable oil renewable diesel (HVORD) on criteria aerosol and gaseous emissions from an older-technology, naturally aspirated, mechanically controlled engine equipped with a diesel oxidation catalytic converter were compared with those of widely used petroleum-derived, ultralow-sulfur diesels (ULSDs). The emissions were characterized for four selected steady-state conditions. When fueled with FAME biodiesel and HVORD, the engine emitted less aerosols by total particulate mass, total carbon mass, elemental carbon mass and total number than when it was fueled with ULSDs. Compared with ULSDs, FAME biodiesel and HVORD produced aerosols that were characterized by single modal distributions, smaller count median diameters, and lower total and peak concentrations. For the majority of test cases, FAME biodiesel and HVORD favorably affected nitric oxide (NO) and adversely affected nitrogen dioxide (NO 2 ) generation. Therefore, the use of these alternative fuels appears to be a viable tool for the underground mining industry to address the issues related to emissions from diesel engines, and to transition toward more universal solutions provided by advanced engines with integrated exhaust after treatment technologies.

Effects of FAME biodiesel and HVORD on emissions from an older-technology diesel engine

PubMed Central

Bugarski, A.D.; Hummer, J.A.; Vanderslice, S.E.

2017-01-01

The results of laboratory evaluations were used to compare the potential of two alternative, biomass-derived fuels as a control strategy to reduce the exposure of underground miners to aerosols and gases emitted by diesel-powered equipment. The effects of fatty acid methyl ester (FAME) biodiesel and hydrotreated vegetable oil renewable diesel (HVORD) on criteria aerosol and gaseous emissions from an older-technology, naturally aspirated, mechanically controlled engine equipped with a diesel oxidation catalytic converter were compared with those of widely used petroleum-derived, ultralow-sulfur diesels (ULSDs). The emissions were characterized for four selected steady-state conditions. When fueled with FAME biodiesel and HVORD, the engine emitted less aerosols by total particulate mass, total carbon mass, elemental carbon mass and total number than when it was fueled with ULSDs. Compared with ULSDs, FAME biodiesel and HVORD produced aerosols that were characterized by single modal distributions, smaller count median diameters, and lower total and peak concentrations. For the majority of test cases, FAME biodiesel and HVORD favorably affected nitric oxide (NO) and adversely affected nitrogen dioxide (NO2) generation. Therefore, the use of these alternative fuels appears to be a viable tool for the underground mining industry to address the issues related to emissions from diesel engines, and to transition toward more universal solutions provided by advanced engines with integrated exhaust after treatment technologies. PMID:29348698

Alternative Fuels Data Center: Coca-Cola Bottling Co. Brings Hybrids to New

Science.gov Websites

as a great example of a viable clean transportation option for similar fleets. " Rebecca Otte commitment to a more sustainable community and serves as a great example of a viable clean transportation , individual bottling companies now operate these vehicles. For example, Coca-Cola Bottling Company United

Blood-based detection of RAS mutations to guide anti-EGFR therapy in colorectal cancer patients: concordance of results from circulating tumor DNA and tissue-based RAS testing.

PubMed

Schmiegel, Wolff; Scott, Rodney J; Dooley, Susan; Lewis, Wendy; Meldrum, Cliff J; Pockney, Peter; Draganic, Brian; Smith, Steve; Hewitt, Chelsee; Philimore, Hazel; Lucas, Amanda; Shi, Elva; Namdarian, Kateh; Chan, Timmy; Acosta, Danilo; Ping-Chang, Su; Tannapfel, Andrea; Reinacher-Schick, Anke; Uhl, Waldemar; Teschendorf, Christian; Wolters, Heiner; Stern, Josef; Viebahn, Richard; Friess, Helmut; Janssen, Klaus-Peter; Nitsche, Ulrich; Slotta-Huspenina, Julia; Pohl, Michael; Vangala, Deepak; Baraniskin, Alexander; Dockhorn-Dworniczak, Barbara; Hegewisch-Becker, Susanne; Ronga, Philippe; Edelstein, Daniel L; Jones, Frederick S; Hahn, Stephan; Fox, Stephen B

2017-02-01

An accurate blood-based RAS mutation assay to determine eligibility of metastatic colorectal cancer (mCRC) patients for anti-EGFR therapy would benefit clinical practice by better informing decisions to administer treatment independent of tissue availability. The objective of this study was to determine the level of concordance between plasma and tissue RAS mutation status in patients with mCRC to gauge whether blood-based RAS mutation testing is a viable alternative to standard-of-care RAS tumor testing. RAS testing was performed on plasma samples from newly diagnosed metastatic patients, or from recurrent mCRC patients using the highly sensitive digital PCR technology, BEAMing (beads, emulsions, amplification, and magnetics), and compared with DNA sequencing data of respective FFPE (formalin-fixed paraffin-embedded) tumor samples. Discordant tissue RAS results were re-examined by BEAMing, if possible. The prevalence of RAS mutations detected in plasma (51%) vs. tumor (53%) was similar, in accord with the known prevalence of RAS mutations observed in mCRC patient populations. The positive agreement between plasma and tumor RAS results was 90.4% (47/52), the negative agreement was 93.5% (43/46), and the overall agreement (concordance) was 91.8% (90/98). The high concordance of plasma and tissue results demonstrates that blood-based RAS mutation testing is a viable alternative to tissue-based RAS testing. © 2016 The Authors. Published by FEBS Press and John Wiley & Sons Ltd.

Variation at work: alternations between physically and mentally demanding tasks in blue-collar occupations.

PubMed

Jahncke, Helena; Hygge, Staffan; Mathiassen, Svend Erik; Hallman, David; Mixter, Susanna; Lyskov, Eugene

2017-09-01

The aims of this questionnaire study were to describe the occurrence and desired number of alternations between mental and physical tasks in industrial and non-industrial blue-collar work, and determine to which extent selected personal and occupational factors influence these conditions. On average, the 122 participating workers (55 females) reported to have close to four alternations per day between mental and physical tasks, and to desire more alternations than they actually had. They also expressed a general preference for performing a physical task after a mental task and vice versa. In univariate regression models, the desired change in task alternations was significantly associated with gender, age, occupation, years with current work tasks and perceived job control, while occupation was the only significant determinant in a multiple regression model including all factors. Our results suggest that alternations between productive physical and mental tasks could be a viable option in future job rotation. Practitioner Summary: We addressed attitudes among blue-collar workers to alternations between physically and mentally demanding tasks. More alternations were desired than those occurring in the job, and workers preferred performing a physical task after a mental and vice versa. Alternating physical and mental tasks could, thus, be a viable option in job rotation.

Adapting sustainable low-carbon techologies to reduce carbon dioxide emissions from coal-fired power plants in China

NASA Astrophysics Data System (ADS)

Kuo, Peter Shyr-Jye

1997-09-01

The scientific community is deeply concerned about the effect of greenhouse-gases (GHGs) on global climate change. A major climate shift can result in tragic destruction to our world. Carbon dioxide (COsb2) emissions from coal-fired power plants are major anthropogenic sources that contribute to potential global warming. The People's Republic of China, with its rapidly growing economy and heavy dependence on coal-fired power plants for electricity, faces increasingly serious environmental challenges. This research project seeks to develop viable methodologies for reducing the potential global warming effects and serious air pollution arising from excessive coal burning. China serves as a case study for this research project. Major resolution strategies are developed through intensive literature reviews to identify sustainable technologies that can minimize adverse environmental impacts while meeting China's economic needs. The research thereby contributes technological knowledge to the field of Applied Sciences. The research also integrates modern power generation technologies with China's current and future energy requirements. With these objectives in mind, this project examines how China's environmental issues are related to China's power generation methods. This study then makes strategic recommendations that emphasize low-carbon technologies as sustainable energy generating options to be implemented in China. These low-carbon technologies consist of three options: (1) using cleaner fuels converted from China's plentiful domestic coal resources; (2) applying high-efficiency gas turbine systems for power generation; and (3) integrating coal gasification processes with energy saving combined cycle gas turbine systems. Each method can perform independently, but a combined strategy can achieve the greatest COsb2 reductions. To minimize economic impacts caused by technological changes, this study also addresses additional alternatives that can be implemented in parallel with the proposed technologies. Principal options include promoting wind, solar and biogas as alternative energies; encouraging reforestation; using economic incentives to change energy policies; and gradually replacing obsolete facilities with new power plants. This study finds that the limited capacity and associated costs of alternative energies are the main factors that prevent competition with coal-based energy in China today.

Energy Efficient Community Development in California: Chula Vista Research Project

DOE Office of Scientific and Technical Information (OSTI.GOV)

Gas Technology Institute

2009-03-31

In 2007, the U.S. Department of Energy joined the California Energy Commission in funding a project to begin to examine the technical, economic and institutional (policy and regulatory) aspects of energy-efficient community development. That research project was known as the Chula Vista Research Project for the host California community that co-sponsored the initiative. The researches proved that the strategic integration of the selected and economically viable buildings energy efficiency (EE) measures, photovoltaics (PV), distributed generation (DG), and district cooling can produce significant reductions in aggregate energy consumption, peak demand and emissions, compared to the developer/builder's proposed baseline approach. However, themore » central power plant emission reductions achieved through use of the EE-DG option would increase local air emissions. The electric and natural gas utility infrastructure impacts associated with the use of the EE and EE-PV options were deemed relatively insignificant while use of the EE-DG option would result in a significant reduction of necessary electric distribution facilities to serve a large-scale development project. The results of the Chula Vista project are detailed in three separate documents: (1) Energy-Efficient Community Development in California; Chula Vista Research Project report contains a detailed description of the research effort and findings. This includes the methodologies, and tools used and the analysis of the efficiency, economic and emissions impacts of alternative energy technology and community design options for two development sites. Research topics covered included: (a) Energy supply, demand, and control technologies and related strategies for structures; (b) Application of locally available renewable energy resources including solar thermal and PV technology and on-site power generation with heat recovery; (c) Integration of local energy resources into district energy systems and existing energy utility networks; (d) Alternative land-use design and development options and their impact on energy efficiency and urban runoff, emissions and the heat island effect; and (e) Alternative transportation and mobility options and their impact on local emissions. (2) Creating Energy-Efficient Communities in California: A Reference Guide to Barriers, Solutions and Resources report provides the results of an effort to identify the most innovative existing and emerging public policy, incentive and market mechanisms that encourage investment in advanced energy technologies and enabling community design options in the State of California and the nation. The report evaluates each of these mechanisms in light of the preceding research and concludes with a set of recommended mechanisms designed for consideration by relevant California State agencies, development and finance industry associations, and municipal governments. (3) Creating Energy-Efficient Communities in California: A Technical Reference Guide to Building and Site Design report contains a set of selected commercially viable energy technology and community design options for high-efficiency, low-impact community development in California. It includes a summary of the research findings referenced above and recommendations for energy technology applications and energy-efficient development strategies for residential, commercial and institutional structures and supporting municipal infrastructure for planned communities. The document also identifies design options, technology applications and development strategies that are applicable to urban infill projects.« less

Quality Alternative Certification Programs in Special Education Ensure High Retention

ERIC Educational Resources Information Center

Karge, Belinda D.; McCabe, Marjorie

2014-01-01

Market driven alternative routes to teaching have evolved into a quality program option and not just an answer to the teacher shortage. Alternative certification is a viable means of recruiting, training, and certifying those who have a bachelor's degree and a strong desire to enter the field of teaching. California has been a leader in the…

Quantum ballistic analysis of transition metal dichalcogenides based double gate junctionless field effect transistor and its application in nano-biosensor

NASA Astrophysics Data System (ADS)

Shadman, Abir; Rahman, Ehsanur; Khosru, Quazi D. M.

2017-11-01

To reduce the thermal budget and the short channel effects in state of the art CMOS technology, Junctionless field effect transistor (JLFET) has been proposed in the literature. Numerous experimental, modeling, and simulation based works have been done on this new FET with bulk materials for various geometries until now. On the other hand, the two-dimensional layered material is considered as an alternative to current Si technology because of its ultra-thin body and high mobility. Very recently few simulation based works have been done on monolayer molybdenum disulfide based JLFET mainly to show the advantage of JLFET over conventional FET. However, no comprehensive simulation-based work has been done for double gate JLFET keeping in mind the prominent transition metal dichalcogenides (TMDC) to the authors' best knowledge. In this work, we have studied quantum ballistic drain current-gate voltage characteristics of such FETs within non-equilibrium Green's function (NEGF) framework. Our simulation results reveal that all these TMDC materials are viable options for implementing state of the art Junctionless MOSFET with emphasis on their performance at short gate lengths. Besides evaluating the prospect of TMDC materials in the digital logic application, the performance of Junctionless Double Gate trilayer TMDC heterostructure FET for the label-free electrical detection of biomolecules in dry environment has been investigated for the first time to the authors' best knowledge. The impact of charge neutral biomolecules on the electrical characteristics of the biosensor has been analyzed under dry environment situation. Our study shows that these materials could provide high sensitivity in the sub-threshold region as a channel material in nano-biosensor, a trend demonstrated by silicon on insulator FET sensor in the literature. Thus, going by the trend of replacing silicon with these novel materials in device level, TMDC heterostructure could be a viable alternative to silicon for potentiometric biosensing.

Break-even cost of cloning in genetic improvement of dairy cattle.

PubMed

Dematawewa, C M; Berger, P J

1998-04-01

Twelve different models for alternative progeny-testing schemes based on genetic and economic gains were compared. The first 10 alternatives were considered to be optimally operating progeny-testing schemes. Alternatives 1 to 5 considered the following combinations of technologies: 1) artificial insemination, 2) artificial insemination with sexed semen, 3) artificial insemination with embryo transfer, 4) artificial insemination and embryo transfer with few bulls as sires, and 5) artificial insemination, embryo transfer, and sexed semen with few bulls, respectively. Alternatives 6 to 12 considered cloning from dams. Alternatives 11 and 12 considered a regular progeny-testing scheme that had selection gains (intensity x accuracy x genetic standard deviation) of 890, 300, 600, and 89 kg, respectively, for the four paths. The sums of the generation intervals of the four paths were 19 yr for the first 8 alternatives and 19.5, 22, 29, and 29.5 yr for alternatives 9 to 12, respectively. Rates of genetic gain in milk yield for alternatives 1 to 5 were 257, 281, 316, 327, and 340 kg/yr, respectively. The rate of gain for other alternatives increased as number of clones increased. The use of three records per clone increased both accuracy and generation interval of a path. Cloning was highly beneficial for progeny-testing schemes with lower intensity and accuracy of selection. The discounted economic gain (break-even cost) per clone was the highest ($84) at current selection levels using sexed semen and three records on clones of the dam. The total cost associated with cloning has to be below $84 for cloning to be an economically viable option.

Composting on Mars or the Moon: I. Comparative evaluation of process design alternatives

NASA Technical Reports Server (NTRS)

Finstein, M. S.; Strom, P. F.; Hogan, J. A.; Cowan, R. M.; Janes, H. W. (Principal Investigator)

1999-01-01

As a candidate technology for treating solid wastes and recovering resources in bioregenerative Advanced Life Support, composting potentially offers such advantages as compactness, low mass, near ambient reactor temperatures and pressures, reliability, flexibility, simplicity, and forgiveness of operational error or neglect. Importantly, the interactions among the physical, chemical, and biological factors that govern composting system behavior are well understood. This article comparatively evaluates five Generic Systems that describe the basic alternatives to composting facility design and control. These are: 1) passive aeration; 2) passive aeration abetted by mechanical agitation; 3) forced aeration--O2 feedback control; 4) forced aeration--temperature feedback control; 5) forced aeration--integrated O2 and temperature feedback control. Each of the five has a distinctive pattern of behavior and process performance characteristics. Only Systems 4 and 5 are judged to be viable candidates for ALS on alien worlds, though which is better suited in this application is yet to be determined.

A study of low-cost, robust assistive listening system (ALS) based on digital wireless technology.

PubMed

Israsena, P; Dubsok, P; Pan-Ngum, S

2008-11-01

We have developed a simple, low-cost digital wireless broadcasting system prototype, intended for a classroom of hearing impaired students. The system is designed to be a low-cost alternative to an existing FM system. The system implemented is for short-range communication, with a one-transmitter, multiple-receiver configuration, which is typical for these classrooms. The data is source-coded for voice-band quality, FSK modulated, and broadcasted via a 915 MHz radio frequency. A DES encryption can optionally be added for better information security. Test results show that the system operating range is approximately ten metres, and the sound quality is close to telephone quality as intended. We also discuss performance issues such as sound, power and size, as well as transmission protocols. The test results are the proof of concept that the prototype is a viable alternative to an existing FM system. Improvements can be made to the system's sound quality via techniques such as channel coding, which is also discussed.

Alternatives Analysis for the Resumption of Transient Testing Program

DOE Office of Scientific and Technical Information (OSTI.GOV)

Lee Nelson

2013-11-01

An alternatives analysis was performed for resumption of transient testing. The analysis considered eleven alternatives – including both US international facilities. A screening process was used to identify two viable alternatives from the original eleven. In addition, the alternatives analysis includes a no action alternative as required by the National Environmental Policy Act (NEPA). The alternatives considered in this analysis included: 1. Restart the Transient Reactor Test Facility (TREAT) 2. Modify the Annular Core Research Reactor (ACRR) which includes construction of a new hot cell and installation of a new hodoscope. 3. No Action

Job Sharing Provides a Useful Alternative.

ERIC Educational Resources Information Center

Plant, Sheila

1985-01-01

Job sharing is discussed as alternative approach to traditional professional librarian work arrangements and viable solution for: working mothers wanting part-time, career-oriented jobs; end-of-career librarians near retirement; those who desire increased leisure. Employers' reluctance is outlined noting increased expense, salary problems,…

Television and Our Children. A Report of the Activities of the Alternatives in Children's Broadcasting Project.

ERIC Educational Resources Information Center

Mainse, David

Two major objectives of the Alternatives in Children's Broadcasting Project were to determine the extent of the influence of violence in children's television and to determine if children's interest in prosocial programming makes it a viable alternative to violence programming. Both adults and 8-10 year old children were surveyed about their…

A 1987 overview of free-piston Stirling technology for space power application

NASA Technical Reports Server (NTRS)

Slaby, Jack G.; Alger, Donald L.

1987-01-01

An overview is presented of the NASA Lewis Research Center free-piston Stirling engine activities directed toward space-power application. NASA Lewis serves as the project office to manage the newly initiated NASA SP-100 Advanced Technology Program. One of the major elements of this five-year program is the development of advanced power conversion concepts of which the Stirling cycle is a viable growth candidate. Under this program the status of the 25 kWe opposed-piston Space Power Demonstrator Engine (SPDE) is presented. Included in the SPDE discussion are comparisons between predicted and experimental engine performance, enhanced performance resulting from regenerator modification, increased operating stroke brought about by isolating the gas bearing flow between the displacer and power piston, identifying excessive energy losses and recommending corrective action, and a better understanding of linear alternator design and operation. Technology work is also conducted on heat exchanger concepts, both design and fabrication. Design parameters and conceptual design features are also presented for a 25 kWe, single-cylinder free-piston Stirling space-power converter.

Biofuels from algae: challenges and potential

PubMed Central

Hannon, Michael; Gimpel, Javier; Tran, Miller; Rasala, Beth; Mayfield, Stephen

2011-01-01

Algae biofuels may provide a viable alternative to fossil fuels; however, this technology must overcome a number of hurdles before it can compete in the fuel market and be broadly deployed. These challenges include strain identification and improvement, both in terms of oil productivity and crop protection, nutrient and resource allocation and use, and the production of co-products to improve the economics of the entire system. Although there is much excitement about the potential of algae biofuels, much work is still required in the field. In this article, we attempt to elucidate the major challenges to economic algal biofuels at scale, and improve the focus of the scientific community to address these challenges and move algal biofuels from promise to reality. PMID:21833344

Summary of the recent short-haul systems studies

NASA Technical Reports Server (NTRS)

Savin, R. C.; Galloway, T. L.; Wilcox, D. E.; Kenyon, G. C.; Ardema, M. D.; Waters, M. H.

1975-01-01

The results of several NASA sponsored high density short haul air transportation systems studies are reported as well as analyzed. Included are the total STOL systems analysis approach, a companion STOL composites study conducted in conjunction with STOL systems studies, a STOL economic assessment study, an evaluation of STOL aircraft with and without externally blown flaps, an alternative STOL systems for the San Francisco Bay Area, and the quiet, clean experimental engine studies. Assumptions and results of these studies are summarized, their differences, analyzed, and the results compared with those in-house analyses performed by the Systems Studies Division of the NASA-Ames Research Center. Pertinent conclusions are developed and the more significant technology needs for the evaluation of a viable short haul transportation system are identified.

Near-field interferometry of a free-falling nanoparticle from a point-like source

NASA Astrophysics Data System (ADS)

Bateman, James; Nimmrichter, Stefan; Hornberger, Klaus; Ulbricht, Hendrik

2014-09-01

Matter-wave interferometry performed with massive objects elucidates their wave nature and thus tests the quantum superposition principle at large scales. Whereas standard quantum theory places no limit on particle size, alternative, yet untested theories—conceived to explain the apparent quantum to classical transition—forbid macroscopic superpositions. Here we propose an interferometer with a levitated, optically cooled and then free-falling silicon nanoparticle in the mass range of one million atomic mass units, delocalized over >150 nm. The scheme employs the near-field Talbot effect with a single standing-wave laser pulse as a phase grating. Our analysis, which accounts for all relevant sources of decoherence, indicates that this is a viable route towards macroscopic high-mass superpositions using available technology.

On the self-serving function of an academic wooden leg: test anxiety as a self-handicapping strategy.

PubMed

Smith, C W; Snyder, D R; Handelsman, M M

1982-02-01

The present study investigated the hypothesis that psychological symptoms may serve a self-protective function by providing an alternative explanation for potential failure in evaluating situations. It was hypothesized that highly test-anxious subjects would report anxiety symptoms in a pattern that reflected strategic presentation of symptoms; more specifically, it was predicted that greater reported anxiety should result when anxiety was a viable explanation for poor performance on an intelligence test and that lower reported anxiety should result when anxiety was not a viable explanation for poor performance. Analysis of state measures of self-reported anxiety supported these predictions. Further analysis indicated that when anxiety was not a viable explanation for poor test performance, high test-anxiety subjects reported reduced effort as an alternative self-protective strategy. These results are discussed in terms of traditional models of symptoms as self-protective strategies, current social psychological models of symptoms, and in reference to recent theory and research about the nature and treatment of test anxiety.

Economic and environmental review of Waste-to-Energy systems for municipal solid waste management in medium and small municipalities.

PubMed

Fernández-González, J M; Grindlay, A L; Serrano-Bernardo, F; Rodríguez-Rojas, M I; Zamorano, M

2017-09-01

The application of Directive 2008/98/CE on Municipal Solid Waste (MSW) implies the need to introduce technologies to generate energy from waste. Incineration, the most widely used method, is difficult to implement in low populated areas because it requires a large amount of waste to be viable (100,000 tons per year). This paper analyses the economic and environmental costs of different MSW-to-Energy technologies (WtE) in an area comprising of 13 municipalities in southern Spain. We analyse anaerobic digestion (Biomethanization), the production of solid recovered fuel (SRF) and gasification, and compare these approaches to the present Biological Mechanical Treatment (BMT) with elimination of the reject in landfill, and incineration with energy recovery. From an economic standpoint the implementation of WtE systems reduces the cost of running present BMT systems and incineration; gasification presents the lowest value. From the environmental standpoint, Life Cycle Assessment shows that any WtE alternatives, including incineration, present important advantages for the environment when compared to BMT. Finally, in order to select the best alternative, a multi-criteria method is applied, showing that anaerobic digestion is the optimal solution for the area studied. Copyright © 2017 Elsevier Ltd. All rights reserved.

An analysis of natural ventilation techniques to achieve indoor comfort in Wal-Mart express

NASA Astrophysics Data System (ADS)

O'Dea, Shona

Despite global efforts to reduce world fossil fuel dependency the world still obtains 81% of its energy from fossil fuels (IEA,2009). Modern renewable alternatives have been around since the mid twentieth century these alternatives have not been integrated into electrical grid systems at the exponential rate required to eradicate fossil fuels dependency. The problem, world energy demand, is too large to be satisfied by anything other than the energy-dense fossil fuels used today. We must change our energy intensive processes in order to conserve energy and hence reduce the demands that alternatives must satisfy. This research aims to identify sustainable design opportunities through the application of innovative technologies for the largest retailer in the US with the view that a viable conservative design measure could be applied to the store model, which is replicated across the country, causing a cumulative and hence larger impact on the company energy consumption as a whole. This paper will present the literature available on the 'big box' industry and Wal-Mart, comfort, natural ventilation and building simulation software and then perform an analysis into the viability of naturally ventilating the Wal-Mart Express sales zone using Monodraught natural ventilation windcatcher products

Proteins for breaking barriers in lignocellulosic bioethanol production.

PubMed

Ulaganathan, Kandasamy; Goud, Burragoni S; Reddy, Mettu M; Kumar, Vanaparthi P; Balsingh, Jatoth; Radhakrishna, Surabhi

2015-01-01

Reduction in fossil fuel consumption by using alternate sources of energy is a major challenge facing mankind in the coming decades. Bioethanol production using lignocellulosic biomass is the most viable option for addressing this challenge. Industrial bioconversion of lignocellulosic biomass, though possible now, is not economically viable due to presence of barriers that escalate the cost of production. As cellulose and hemicellulose are the major constituents of terrestrial biomass, which is available in massive quantities, hydrolysis of cellulose and hemicellulose by the microorganisms are the most prominent biochemical processes happening in the earth. Microorganisms possess different categories of proteins associated with different stages of bioethanol production and a number of them are already found and characterized. Many more of these proteins need to be identified which suit the specificities needed for the bioethanol production process. Discovery of proteins with novel specificities and application of genetic engineering technologies to harvest the synergies existing between them with the aim to develop consolidated bioprocess is the major direction of research in the future. In this review, we discuss the different categories of proteins used for bioethanol production in the context of breaking the barriers existing for the economically feasible lignocellulosic bioethanol production.

Rethinking chiller plant design

DOE Office of Scientific and Technical Information (OSTI.GOV)

Meckler, M.

1998-07-01

While most refrigeration chillers operate today on electricity, the use of natural gas is becoming an increasingly attractive alternative. This is largely because electricity does not use energy very efficiency (because of transmission and combustion fuel losses), high demand charges, and the high incremental cost of electricity to operate chillers. The use of gas engine-driven chillers eliminates the high incremental cost of electricity. Additionally, gas engine-driven systems can operate with COPs up to 1.8 and, therefore, are economically viable alternatives. Recent advances in gas engine-driven and DFA absorption chillers, and in commercially viable solid and liquid desiccant-cooling systems, suggest amore » bright future for the gas industry. The use of such equipment in conjunction with or in place of commercially available electrical-powered alternatives can significantly impact demand-side management savings for utility ratepayers in the short run and provide significant hybrid opportunities for deregulated markets in the intermediate to long term.« less

Rethinking chiller plant design

DOE Office of Scientific and Technical Information (OSTI.GOV)

Meckler, M.

1998-01-01

While most refrigeration chillers operate today on electricity, the use of natural gas is becoming an increasingly attractive alternative. This is largely because electricity does not use energy very efficiently (due to transmission and combustion fuel losses), high demand charges, and the high incremental cost of electricity to operate chillers. The use of gas engine-driven chillers eliminates the high incremental cost of electricity. Additionally, gas engine-driven systems can operate with COPs up to 1.8 and therefore are economically viable alternatives. Recent advances in gas engine-driven and direct-fired absorption chillers and in commercially viable solid- and liquid-desiccant cooling systems suggest amore » bright future for the gas industry. The use of such equipment in conjunction with or in place of commercially available electrical-powered alternatives can significantly impact demand-side management savings for utility ratepayers in the short run and provide significant hybrid opportunities for deregulated markets in the intermediate to long term.« less

Satellite Power Systems (SPS) Concept Definition Study. Volume 1: Executive Summary

NASA Technical Reports Server (NTRS)

Hanley, G.

1978-01-01

The evolution of a total satellite power is described as well as major subsystem alternatives. Trade study results are given for satellite concepts, ground receiving antennas, satellite construction sites, and transportation. Point design definition, end-to-end analysis, and programmatics are covered. The GaAlAs photovoltaic concept is recommended as the current preliminary baseline satellite concept with silicon photovoltaic and Rankine cycle solar-thermal concepts as viable alternatives. Geosynchronous orbit is preferred for the construction of the satellite. A horizontal takeoff and landing air breathing rocket HLLV concept is preferred for earth-to-LEO transportation, with vertical takeoff options as viable alternatives. An argon electric orbit transfer vehicle is preferred for cargo transport from LEO and GEO orbit, and a chemical LH2/L02, two-stage orbit transfer vehicle is recommended for crew transport. A stripline rectenna array is the current preferred concept.

Wind Energy Program Summary. Volume 2: Research summaries, fiscal year 1988

NASA Astrophysics Data System (ADS)

1989-04-01

Activities by the Federal Wind Energy program since the early 1980s have focused on developing a technology base necessary for industry to demonstrate the viability of wind energy as an alternative energy supply. The Federal Wind Energy Program's research has targeted the sciences of wind turbine dynamics and the development of advanced components and systems. These efforts have resulted in major advancements toward the development and commercialization of wind technology as an alternative energy source. The installation of more than 16,000 wind turbines in California by the end of 1987 provides evidence that commercial use of wind energy technology can be a viable source of electric power. Research in wind turbine sciences has focused on atmospheric fluid dynamics, aerodynamics, and structural dynamics. As outlines in the projects that are described in this document, advancements in atmospheric fluid dynamics have been made through the development and refinement of wind characterization models and wind/rotor interaction prediction codes. Recent gains in aerodynamics can be attributed to a better understanding of airfoil operations, using innovative research approaches such as flow-visualization techniques. Qualitative information and data from laboratory and field tests are being used to document fatigue damage processes. These data are being used to develop new theories and data bases for structural dynamics, and will help to achieve long-term unit life and lower capital and maintenance costs. Material characterization and modeling techniques have been improved to better analyze effects of stress and fatigue on system components.

Alternative Pathways into University: Are Tertiary Preparation Programs a Viable Option?

ERIC Educational Resources Information Center

Chesters, Jenny; Rutter, Kerry; Nelson, Karen; Watson, Louis

2018-01-01

During the past three decades, the student populations of Australian universities have become more heterogeneous as the higher education sector expanded and new alternative entry pathways were established. Broadening access to university study and, therefore, to professional and semi-professional occupations, provides avenues for social mobility.…

Flue gas desulfurization gypsum: Its effectiveness as an alternative bedding material for broiler production

USDA-ARS?s Scientific Manuscript database

Flue gas desulfurization gypsum (FGDG) may be a viable low-cost alternative bedding material for broiler production. In order to evaluate FGD gypsum’s viability, three consecutive trials were conducted to determine its influence on live performance (body weight, feed consumption, feed efficiency, an...

Nuclear Cryogenic Propulsion Stage Affordable Development Strategy

NASA Technical Reports Server (NTRS)

Doughty, Glen E.; Gerrish, H. P.; Kenny, R. J.

2014-01-01

The development of nuclear power for space use in nuclear thermal propulsion (NTP) systems will involve significant expenditures of funds and require major technology development efforts. The development effort must be economically viable yet sufficient to validate the systems designed. Efforts are underway within the National Aeronautics and Space Administration's (NASA) Nuclear Cryogenic Propulsion Stage Project (NCPS) to study what a viable program would entail. The study will produce an integrated schedule, cost estimate and technology development plan. This will include the evaluation of various options for test facilities, types of testing and use of the engine, components, and technology developed. A "Human Rating" approach will also be developed and factored into the schedule, budget and technology development approach.

Embryo Space Colonisation to Overcome the Interstellar Time Distance Bottleneck

NASA Astrophysics Data System (ADS)

Crowl, A.; Hunt, J.; Hein, A. M.

The immense distances to neighbouring star systems pose the single greatest challenge to a true interstellar mission. The challenge is made even greater if the purpose of the mission is scientific in which it is commonly stated that the mission should last no longer than the career of a participating scientist. This imposes speed requirements with a host of well-known problems of propulsion, immense vehicle mass, need for in-space infrastructure, impact hazards, proton flux, and deceleration. If instead the purpose of the interstellar mission is to ensure the survival of humanity by establishing a viable colony using frozen embryos, these many problems are potentially mitigated due to the fact that the speeds can be much slower. Sleeper ships are a suggested low speed alternative, but cosmic ray damage to suspended/frozen humans could place a limit on the acceptable duration of the mission thereby necessitating greater speed with the aforementioned challenges. Near-term solar-sail technology could be sufficient to launch an ESC mission once human ectogenetic technology has matured.

Thermal Protection System (Heat Shield) Development - Advanced Development Project

NASA Technical Reports Server (NTRS)

Kowal, T. John

2010-01-01

The Orion Thermal Protection System (TPS) ADP was a 3 1/2 year effort to develop ablative TPS materials for the Orion crew capsule. The ADP was motivated by the lack of available ablative TPS's. The TPS ADP pursued a competitive phased development strategy with succeeding rounds of development, testing and down selections. The Project raised the technology readiness level (TRL) of 8 different TPS materials from 5 different commercial vendors, eventual down selecting to a single material system for the Orion heat shield. In addition to providing a heat shield material and design for Orion on time and on budget, the Project accomplished the following: 1) Re-invigorated TPS industry & re-established a NASA competency to respond to future TPS needs; 2) Identified a potentially catastrophic problem with the planned MSL heat shield, and provided a viable, high TRL alternate heat shield design option; and 3) Transferred mature heat shield material and design options to the commercial space industry, including TPS technology information for the SpaceX Dragon capsule.

EVALUATION OF VADOSE ZONE TREATMENT TECHNOLOGIES TO IMMOBILIZE TECHNETIUM-99

DOE Office of Scientific and Technical Information (OSTI.GOV)

PETERSEN, S.W.

2006-03-15

The Hanford Site End State Vision document (DOE/RL-2003-59) states: ''There should be an aggressive plan to develop technology for remediation of the contamination that could get to the groundwater (particularly the technetium [{sup 99}Tc])''. In addition, there is strong support from the public and regulatory agencies for the above statement, with emphasis on investigation of treatment alternatives. In July 2004, PNNL completed a preliminary evaluation of remediation technologies with respect to their effectiveness and implementability for immobilization of {sup 99}Tc beneath the BC Cribs in the 200 West Area (Truex, 2004). As a result of this evaluation, PNNL recommended treatabilitymore » testing of in situ soil desiccation, because it has the least uncertainty of those technologies evaluated in July 2004 (Treatability Test Outline, September 30, 2004). In 2005, DOE-RL and Fluor Hanford convened an independent technical panel to review alternative remediation technologies, including desiccation, at a three-day workshop in Richland, Washington. The panel was composed of experts in vadose-zone transport, infiltration control, hydrology, geochemistry, environmental engineering, and geology. Their backgrounds include employment in academia, government laboratories, industry, and consulting. Their review, presented in this document, is based upon written reports from Hanford, oral presentations from Hanford staff, and each panel members' years of experience in their particular field of expertise. The purpose of this report is to document the panel's evaluation of various treatment alternatives with potential for minimizing contaminant migration in the deep vadose zone at the Department of Energy Hanford Site. The panel was tasked with assessing the most viable and practical approach and making recommendations for testing. The evaluation of vadose-zone treatment alternatives was conducted to be broadly applicable at a variety of locations at Hanford. However, because of limitations of time, the panel was asked to focus on one example, {sup 99}Tc contamination below the BC Cribs and Trenches. It is well recognized that conditions at BC Cribs and Trenches are not the same as those at other Hanford locations, but it was selected so that the panel could develop an understanding of site conditions at one location. The recommendations in this report are not intended to address the regulatory decision process for this site.« less

Alternative Practice Dental Hygiene in California: Past, Present, and Future

PubMed Central

MERTZ, ELIZABETH; GLASSMAN, PAUL

2012-01-01

This study examines the development of the registered dental hygienist in alternative practice in California through an analysis of archival documents, stakeholder interviews, and two surveys of the registered dental hygienist in alternative practice. Designing, testing and implementing a new practice model for dental hygienists took 23 years. Today, registered dental hygienists in alternative practice have developed viable alternative methods for delivering preventive oral health care services in a range of settings with patients who often have no other source of access to care. PMID:21337961

Hermeneutic-Narrative Approach to Career Counselling: An Alternative to Postmodernism

ERIC Educational Resources Information Center

Thrif, Erin; Amundson, Norman

2005-01-01

Postmodern approaches to career counselling have been suggested as a viable alternative to traditional career theories that rely on modernist assumptions. However, some of the assumptions that underlie postmodernism may prove to be unhelpful to career development practice in the long run. In this article we examine critiques of postmodern…

Application of the Cross Battery Approach in the Assessment of American Indian Children: A Viable Alternative.

ERIC Educational Resources Information Center

Plank, Gary A.

2001-01-01

Current psychometric and testing practices are inadequate for assessing the intelligence of American Indian students, due to complicating factors of culture and language. These deficient methods are then used to make educational decisions, resulting in improper special education placements. The benefits of alternative methods of testing, including…

Local alternative energy futures: developing economies/building communities

DOE Office of Scientific and Technical Information (OSTI.GOV)

Totten, M.; Glass, B.; Freedberg, M.

A separate abstract was prepared for each of the three parts of the conference. A sufficient range of information is presented to enable interested parties to explore the viable alternatives for community self-sufficiency. The parts are entitled: Financial Incentives and Funding Sources; Standards, Regulations, Mandates, Ordinances, Covenants; and Community/Economic Development. (MCW)

DEMONSTRATION OF N-METHYL PYRROLIDONE (NMP) AS A POLLUTION PREVENTION ALTERNATIVE TO PAINT STRIPPING WITH METHYLENE CHLORIDE

EPA Science Inventory

This objective of this paper is to demonstrate that NMP is a viable pollution prevention alternative to methylene chloride. Maine Corps Logistics Base (MCLB), Albany, GA, USA was the host site for the demonstration. MCLB's primary function is maintenance of military ground supp...

What Does Galileo's Discovery of Jupiter's Moons Tell Us about the Process of Scientific Discovery?

ERIC Educational Resources Information Center

Lawson, Anton E.

2002-01-01

Given that hypothetico-deductive reasoning has played a role in other important scientific discoveries, asks the question whether it plays a role in all important scientific discoveries. Explores and rejects as viable alternatives possible alternative scientific methods such as Baconian induction and combinatorial analysis. Discusses the…

Combating Opium in Afghanistan. Strategic Forum, Number 224, November 2006

DTIC Science & Technology

2006-11-01

strategy will be severely limited.17 Truffles, a fungi delicacy, are the only legal agricultural product whose value rivals that of opium poppy...to bear fruit and are not viable sources of income over the short term. Wheat , a favorite substitute of Western aid agencies, does not provide a...viable alternative for farmers. Income from poppy production is approximately $5,400 per hectare, while wheat brings in $500. Farmers claim that

Technology Utilization Conference Series, volume 1

NASA Technical Reports Server (NTRS)

1975-01-01

The design, development, and results of a series of technology utilization conferences are presented. The conference series represents the development of a viable and successful means of encouraging the transfer of technology to the minority business community.

Alternatives to Testosterone Therapy: A Review.

PubMed

Lo, Eric M; Rodriguez, Katherine M; Pastuszak, Alexander W; Khera, Mohit

2018-01-01

Although testosterone therapy (TTh) is an effective treatment for hypogonadism, recent concerns regarding its safety have been raised. In 2015, the US Food and Drug Administration issued a warning about potential cardiovascular risks resulting from TTh. Fertility preservation is another reason to search for viable alternative therapies to conventional TTh, and in this review we evaluate the literature examining these alternatives. To review the role and limitations of non-testosterone treatments for hypogonadism. A literature search was conducted using PubMed to identify relevant studies examining medical and non-medical alternatives to TTh. Search terms included hypogonadism, testosterone replacement therapy, testosterone therapy, testosterone replacement alternatives, diet and exercise and testosterone, varicocele repair and testosterone, stress reduction and testosterone, and sleep apnea and testosterone. Review of peer-reviewed literature. Medical therapies examined include human chorionic gonadotropins, aromatase inhibitors, and selective estrogen receptor modulators. Non-drug therapies that are reviewed include lifestyle modifications including diet and exercise, improvements in sleep, decreasing stress, and varicocele repair. The high prevalence of obesity and metabolic syndrome in the United States suggests that disease modification could represent a viable treatment approach for affected men with hypogonadism. These alternatives to TTh can increase testosterone levels and should be considered before TTh. Lo EM, Rodriguez KM, Pastuszak AW, Khera M. Alternatives to Testosterone Therapy: A Review. Sex Med Rev 2018;6:106-113. Copyright © 2017. Published by Elsevier Inc.

Development of a Risk-Based Comparison Methodology of Carbon Capture Technologies

DOE Office of Scientific and Technical Information (OSTI.GOV)

Engel, David W.; Dalton, Angela C.; Dale, Crystal

2014-06-01

Given the varying degrees of maturity among existing carbon capture (CC) technology alternatives, an understanding of the inherent technical and financial risk and uncertainty associated with these competing technologies is requisite to the success of carbon capture as a viable solution to the greenhouse gas emission challenge. The availability of tools and capabilities to conduct rigorous, risk–based technology comparisons is thus highly desirable for directing valuable resources toward the technology option(s) with a high return on investment, superior carbon capture performance, and minimum risk. To address this research need, we introduce a novel risk-based technology comparison method supported by anmore » integrated multi-domain risk model set to estimate risks related to technological maturity, technical performance, and profitability. Through a comparison between solid sorbent and liquid solvent systems, we illustrate the feasibility of estimating risk and quantifying uncertainty in a single domain (modular analytical capability) as well as across multiple risk dimensions (coupled analytical capability) for comparison. This method brings technological maturity and performance to bear on profitability projections, and carries risk and uncertainty modeling across domains via inter-model sharing of parameters, distributions, and input/output. The integration of the models facilitates multidimensional technology comparisons within a common probabilistic risk analysis framework. This approach and model set can equip potential technology adopters with the necessary computational capabilities to make risk-informed decisions about CC technology investment. The method and modeling effort can also be extended to other industries where robust tools and analytical capabilities are currently lacking for evaluating nascent technologies.« less

Accurate, efficient, and (iso)geometrically flexible collocation methods for phase-field models

NASA Astrophysics Data System (ADS)

Gomez, Hector; Reali, Alessandro; Sangalli, Giancarlo

2014-04-01

We propose new collocation methods for phase-field models. Our algorithms are based on isogeometric analysis, a new technology that makes use of functions from computational geometry, such as, for example, Non-Uniform Rational B-Splines (NURBS). NURBS exhibit excellent approximability and controllable global smoothness, and can represent exactly most geometries encapsulated in Computer Aided Design (CAD) models. These attributes permitted us to derive accurate, efficient, and geometrically flexible collocation methods for phase-field models. The performance of our method is demonstrated by several numerical examples of phase separation modeled by the Cahn-Hilliard equation. We feel that our method successfully combines the geometrical flexibility of finite elements with the accuracy and simplicity of pseudo-spectral collocation methods, and is a viable alternative to classical collocation methods.

Contrast medium administration and image acquisition parameters in renal CT angiography: what radiologists need to know.

PubMed

Saade, Charbel; Deeb, Ibrahim Alsheikh; Mohamad, Maha; Al-Mohiy, Hussain; El-Merhi, Fadi

2016-01-01

Over the last decade, exponential advances in computed tomography (CT) technology have resulted in improved spatial and temporal resolution. Faster image acquisition enabled renal CT angiography to become a viable and effective noninvasive alternative in diagnosing renal vascular pathologies. However, with these advances, new challenges in contrast media administration have emerged. Poor synchronization between scanner and contrast media administration have reduced the consistency in image quality with poor spatial and contrast resolution. Comprehensive understanding of contrast media dynamics is essential in the design and implementation of contrast administration and image acquisition protocols. This review includes an overview of the parameters affecting renal artery opacification and current protocol strategies to achieve optimal image quality during renal CT angiography with iodinated contrast media, with current safety issues highlighted.

High magnesium mobility in ternary spinel chalcogenides

DOE Office of Scientific and Technical Information (OSTI.GOV)

Canepa, Pieremanuele; Bo, Shou-Hang; Sai Gautam, Gopalakrishnan

Magnesium batteries appear a viable alternative to overcome the safety and energy density limitations faced by current lithium-ion technology. Furthermore, the development of a competitive magnesium battery is plagued by the existing notion of poor magnesium mobility in solids. We demonstrate by using ab initio calculations, nuclear magnetic resonance, and impedance spectroscopy measurements that substantial magnesium ion mobility can indeed be achieved in close-packed frameworks (~ 0.01-0.1 mS cm -1 at 298 K), specifically in the magnesium scandium selenide spinel. Our theoretical predictions also indicate that high magnesium ion mobility is possible in other chalcogenide spinels, opening the door formore » the realization of other magnesium solid ionic conductors and the eventual development of an all-solid-state magnesium battery.« less

High magnesium mobility in ternary spinel chalcogenides

DOE PAGES

Canepa, Pieremanuele; Bo, Shou-Hang; Sai Gautam, Gopalakrishnan; ...

2017-11-24

Magnesium batteries appear a viable alternative to overcome the safety and energy density limitations faced by current lithium-ion technology. Furthermore, the development of a competitive magnesium battery is plagued by the existing notion of poor magnesium mobility in solids. We demonstrate by using ab initio calculations, nuclear magnetic resonance, and impedance spectroscopy measurements that substantial magnesium ion mobility can indeed be achieved in close-packed frameworks (~ 0.01-0.1 mS cm -1 at 298 K), specifically in the magnesium scandium selenide spinel. Our theoretical predictions also indicate that high magnesium ion mobility is possible in other chalcogenide spinels, opening the door formore » the realization of other magnesium solid ionic conductors and the eventual development of an all-solid-state magnesium battery.« less

Biomass power in transition

DOE Office of Scientific and Technical Information (OSTI.GOV)

Marshall, D.K.

1996-12-31

Electricity production from biomass fuel has been hailed in recent years as an environmentally acceptable energy source that delivers on its promise of economically viable renewable energy. A Wall Street Journal article from three years ago proclaimed wood to be {open_quotes}moving ahead of costly solar panels and wind turbines as the leading renewable energy alternative to air-fouling fossils fuels and scary nuclear plants.{close_quotes} Biomass fuel largely means wood; about 90% of biomass generated electricity comes from burning waste wood, the remainder from agricultural wastes. Biomass power now faces an uncertain future. The maturing of the cogeneration and independent power plantmore » market, restructuring of the electric industry, and technological advances with power equipment firing other fuels have placed biomass power in a competitive disadvantage with other power sources.« less

NASA's GreenLab Research Facility: A Guide for a Self-Sustainable Renewable Energy Ecosystem

NASA Technical Reports Server (NTRS)

Bomani, B. M. McDowell; Hendricks, R. C.; Elbuluk, Malik; Okon, Monica; Lee, Eric; Gigante, Bethany

2011-01-01

There is a large gap between the production and demand for energy from alternative fuel and alternative renewable energy sources. The sustainability of humanity, as we know it, directly depends on the ability to secure affordable fuel, food, and freshwater. NASA Glenn Research Center (Glenn) has initiated a laboratory pilot study on using biofuels as viable alternative fuel resources for the field of aviation, as well as utilizing wind and solar technology as alternative renewable energy resources. The GreenLab Research Facility focuses on optimizing biomass feedstock using algae and halophytes as the next generation of renewable aviation fuels. The unique approach in this facility helps achieve optimal biomass feedstock through climatic adaptation of balanced ecosystems that do not use freshwater, compete with food crops, or use arable land. In addition, the GreenLab Research Facility is powered, in part, by alternative and renewable energy sources, reducing the major environmental impact of present electricity sources. The ultimate goal is to have a 100 percent clean energy laboratory that, when combined with biomass feedstock research, has the framework in place for a self-sustainable renewable energy ecosystem that can be duplicated anywhere in the world and can potentially be used to mitigate the shortage of food, fuel, and water. This paper describes the GreenLab Research Facility at Glenn and its power and energy sources, and provides recommendations for worldwide expansion and adoption of the facility s concept.

Status review of field emission displays

NASA Astrophysics Data System (ADS)

Ghrayeb, Joseph; Daniels, Reginald

2001-09-01

Cathode ray tube (CRT) technology dominates the direct view display market. Mature CRT technology for many designs is still the preferred choice. CRT manufacturers have greatly improved the size and weight of the CRT displays. High performance CRTs continue to be in great demand, however, supply have to contend with the vanishing CRT vendor syndrome. Therefore, the vanishing CRT vendor syndrome fuels the search for an alternate display technology source. Within the past 10 years, field emission display (FED) technology had gained momentum and, at one time, was considered the most viable electronic display technology candidate [to replace the CRT]. The FED community had advocated and promised many advantages over active matrix liquid crystal displays (AMLCD), electro luminescent (EL) or Plasma displays. Some observers, including potential FED manufacturers and the Department of Defense, (especially the Defense Advanced Research Project Agency (DARPA)), consider the FED entry as having leapfrog potential. Despite major investments by US manufacturers as well as Asian manufacturers, reliability and manufacturing difficulties greatly slowed down the advancement of the technology. The FED manufacturing difficulties have caused many would-be FED manufacturing participants to abandon FED research. This paper will examine the trends, which are leading this nascent technology to its downfall. FED technology was once considered to have the potential to leapfrog over AMLCD's dominance in the display industry. At present the FED has suffered severe setbacks and there are very few [FED] manufacturers still pursuing research in the area. These companies have yet to deliver a display beyond the prototype stage.

Scoping Alternatives for Negative Emission Technologies. FRACCC - Possible Routes to Biomass-Derived Carbon Injection in Shallow Aquifers?

NASA Astrophysics Data System (ADS)

Correa Silva, R.; Larter, S.

2016-12-01

Atmospheric CO2 capture into biomass is one of the capture options for negative emission technologies, although proposed sequestration systems such as the permanent burial of total fresh biomass, algal lipids or soil amendment with biochar are yet to be successfully demonstrated as effective at scale. In the context of carbon sequestration, shallow geological reservoirs have not been exhaustively explored, even though they pose, away from groundwater protection zones, potentially low implementation cost, and geographically abundant potential carbon storage reservoirs. Typical carbon storage vectors considered, such as CO2 and biochar, are not suitable for shallow aquifer disposal, due either to cap rock containment requirements, or shallow aquifer CO2 densities, or issues related to formation damage from solid particles. Thus, a cost-effective technology, aimed at converting biomass into a large-scale carbon vector fit-for-disposal in shallow formations could be significant, linking promising carbon capture and containment strategies. In this work, we discuss the development of unconventional carbon vectors for subsurface storage in the form of Functionalized, Refractory and Aqueous Compatible Carbon Compounds (FRACCC), as a potential alternative negative emission technology (Larter et al., 2010). The concept is based on CO2 capture into microbial and algal biomass, followed by the modification of biomass constituents through facile chemical reactions aimed at rendering the biomass efficiently into a stable, biologically refractory but water soluble form, similar in some regards, to dissolved organic matter in the oceans, then sequestering the material in geological settings. As the injected material is not buoyant, containment specifications are more modest than for CO2 injection and potentially, more reservoirs could be accessible! This work analyses the technological, economic and societal implications of such potential FRACCC technologies, and make an assessment of whether such routes are likely to be technically, economically and politically viable.

Detection of Only Viable Bacterial Spores Using a Live/Dead Indicator in Mixed Populations

NASA Technical Reports Server (NTRS)

Behar, Alberto E.; Stam, Christina N.; Smiley, Ronald

2013-01-01

This method uses a photoaffinity label that recognizes DNA and can be used to distinguish populations of bacterial cells from bacterial spores without the use of heat shocking during conventional culture, and live from dead bacterial spores using molecular-based methods. Biological validation of commercial sterility using traditional and alternative technologies remains challenging. Recovery of viable spores is cumbersome, as the process requires substantial incubation time, and the extended time to results limits the ability to quickly evaluate the efficacy of existing technologies. Nucleic acid amplification approaches such as PCR (polymerase chain reaction) have shown promise for improving time to detection for a wide range of applications. Recent real-time PCR methods are particularly promising, as these methods can be made at least semi-quantitative by correspondence to a standard curve. Nonetheless, PCR-based methods are rarely used for process validation, largely because the DNA from dead bacterial cells is highly stable and hence, DNA-based amplification methods fail to discriminate between live and inactivated microorganisms. Currently, no published method has been shown to effectively distinguish between live and dead bacterial spores. This technology uses a DNA binding photoaffinity label that can be used to distinguish between live and dead bacterial spores with detection limits ranging from 109 to 102 spores/mL. An environmental sample suspected of containing a mixture of live and dead vegetative cells and bacterial endospores is treated with a photoaffinity label. This step will eliminate any vegetative cells (live or dead) and dead endospores present in the sample. To further determine the bacterial spore viability, DNA is extracted from the spores and total population is quantified by real-time PCR. The current NASA standard assay takes 72 hours for results. Part of this procedure requires a heat shock step at 80 degC for 15 minutes before the sample can be plated. Using a photoaffinity label would remove this step from the current assay as the label readily penetrates both live and dead bacterial cells. Secondly, the photoaffinity label can only penetrate dead bacterial spores, leaving behind the viable spore population. This would allow for rapid bacterial spore detection in a matter of hours compared to the several days that it takes for the NASA standard assay.

Innovative Technologies and a Technology Selection Roadmap for Optimization of Pipeline Inspection and Assessment

EPA Science Inventory

In the past five years, a multitude of new inspection technologies have emerged as viable sources of pipeline condition data. Furthermore, many of these new technologies provide quantitative (versus qualitative) data that can significantly improve diagnostic and predictive capab...

The Human Interface Technology Laboratory.

ERIC Educational Resources Information Center

Washington Univ., Seattle. Washington Technology Center.

This booklet contains information about the Human Interface Technology Laboratory (HITL), which was established by the Washington Technology Center at the University of Washington to transform virtual world concepts and research into practical, economically viable technology products. The booklet is divided into seven sections: (1) a brief…

Communal sanitation alternatives for slums: A case study of Kibera, Kenya

NASA Astrophysics Data System (ADS)

Schouten, M. A. C.; Mathenge, R. W.

Despite the prominence of communal practices as a last resort for any decent way of sanitation in slum areas, its application and use is flagrantly ignored. This paper provides insight in the appropriateness of communal sanitation facilities for slum conditions. Recent scholarly investigations in developing countries provide theoretical and empirical evidence of a divergence between the expectations from the users of sanitation facilities, and the expectations from other stakeholders. This paper presents the results from a case study in the Kibera slum attached to Nairobi, which is one of the largest African slums. A series of interviews with government agencies, Non-Governmental Organisations and Community Building Organisations was carried out. In addition, a survey was conducted of 76 users of different sanitation facilities. The research culminates in a series of concerns on financial, technological, situational and participatory dimensions. The main conclusion is a firm confirmation that communal sanitation are indeed the only viable alternative for slums, and therefore, the results of the research advocate a serious recognition of the use and appropriateness of communal sanitation for slum dwellers.

Development of a Larvicidal Nanoemulsion with Pterodon emarginatus Vogel Oil

PubMed Central

Oliveira, Anna E. M. F. M.; Duarte, Jonatas L.; Amado, Jesus R. R.; Cruz, Rodrigo A. S.; Rocha, Clarice F.; Souto, Raimundo N. P.; Ferreira, Ricardo M. A.; Santos, Karen; da Conceição, Edemilson C.; de Oliveira, Leandra A. R.; Kelecom, Alphonse; Fernandes, Caio P.; Carvalho, José C. T.

2016-01-01

Pterodon emarginatus Vogel is a Brazilian species that belongs to the family Fabaceae, popularly known as sucupira. Its oil has several biological activities, including potent larvicidal property against Aedes aegypti. This insect is the vector of dengue, a tropical disease that has been considered a critical health problem in developing countries, such as Brazil. Most of dengue control methods involve larvicidal agents suspended or diluted in water and making active lipophilic natural products available is therefore considered a technological challenge. In this context, nanoemulsions appear as viable alternatives to solve this major problem. The present study describes the development of a novel nanoemulsion with larvicidal activity against A. aegypti along with the required Hydrophile Lipophile Balance determination of this oil. It was suggested that the mechanism of action might involve reversible inhibition of acetylcholinesterase and our results also suggest that the P. emarginatus nanoemulsion is not toxic for mammals. Thus, it contributes significantly to alternative integrative practices of dengue control, as well as to develop sucupira based nanoproducts for application in aqueous media. PMID:26742099

Alternatives to clearcutting of old growth in southeast Alaska.

Treesearch

Sally. Duncan

1999-01-01

This issue of Science Findings examines the results of a study designed to provide a broad array of silvicultural options for land managers. Pacific Northwest Research Station scientist Mike McClellan is leading the study and has found that timber harvesting by using alternatives to clearcutting is viable in the current marketplace and technically feasible across a...

Is There Such a Thing as Free Software? The Pros and Cons of Open-Source Software

ERIC Educational Resources Information Center

Trappler, Thomas J.

2009-01-01

Today's higher education environment is marked by heightened accountability and decreased budgets. In such an environment, no higher education institution can afford to ignore alternative approaches that could result in more effective and less costly solutions. Open-source software (OSS) can serve as a viable alternative to traditional proprietary…

Does Teaching Experience Matter? Examining Biology Teachers' Prior Knowledge for Teaching in an Alternative Certification Program

ERIC Educational Resources Information Center

Friedrichsen, Patricia J.; Abell, Sandra K.; Pareja, Enrique M.; Brown, Patrick L.; Lankford, Deanna M.; Volkmann, Mark J.

2009-01-01

Alternative certification programs (ACPs) have been proposed as a viable way to address teacher shortages, yet we know little about how teacher knowledge develops within such programs. The purpose of this study was to investigate prior knowledge for teaching among students entering an ACP, comparing individuals with teaching experience to those…

Evolution of β-Cell Replacement Therapy in Diabetes Mellitus: Islet Cell Transplantation

PubMed Central

Jahansouz, Cyrus; Jahansouz, Cameron; Kumer, Sean C.; Brayman, Kenneth L.

2011-01-01

Diabetes mellitus remains one of the leading causes of morbidity and mortality worldwide. According to the Centers for Disease Control and Prevention, approximately 23.6 million people in the United States are affected. Of these individuals, 5 to 10% have been diagnosed with Type 1 diabetes mellitus (T1DM), an autoimmune disease. Although it often appears in childhood, T1DM may manifest at any age, leading to significant morbidity and decreased quality of life. Since the 1960s, the surgical treatment for diabetes mellitus has evolved to become a viable alternative to insulin administration, beginning with pancreatic transplantation. While islet cell transplantation has emerged as another potential alternative, its role in the treatment of T1DM remains to be solidified as research continues to establish it as a truly viable alternative for achieving insulin independence. In this paper, the historical evolution, procurement, current status, benefits, risks, and ongoing research of islet cell transplantation are explored. PMID:22013505

CFRP composite optical telescope assembly for the 1 m ULTRA project

NASA Astrophysics Data System (ADS)

Martin, Robert N.; Romeo, Robert C.

2006-06-01

The focus of the ULTRA Project is to develop and test Ultra-Lightweight Technology for Research applications in Astronomy. The ULTRA project is a collaborative effort involving the private firm Composite Mirror Applications, Inc (CMA) and 3 universities: University of Kansas, San Diego State University, and Dartmouth College. Funding for ULTRA is predominately from a NSF three year MRI program grant to CMA and KU with additional support from CMA, KU and SDSU. The goal of the ULTRA program is to demonstrate that a viable alternative exists to traditional glass mirror and steel telescope technology by designing, fabricating and testing a research telescope constructed from carbon fiber reinforced plastic (CFRP) materials. In particular, a 1m diameter, Cassegrain telescope optics set and optical tube assembly (OTA) are being designed and fabricated by CMA. The completed telescope will be deployed at SDSU's Mt Laguna Observatory in a refurbished structure (new dome and mount provided via KU and SDSU). We expect that a successful completion and testing of this project will lead to future use of CFRP technology in larger telescopes and segmented telescopes. This paper describes the OTA (optical tube assembly) that has been developed for the ULTRA project. The mirror technology is described in another paper in this conference. A poster describes the ULTRA project overview in more detail.

Processing, properties and applications of composites using powder-coated epoxy towpreg technology

NASA Technical Reports Server (NTRS)

Bayha, T. D.; Osborne, P. P.; Thrasher, T. P.; Hartness, J. T.; Johnston, N. J.; Marchello, J. M.; Hugh, M. K.

1993-01-01

Composite manufacturing using the current prepregging technology of impregnating liquid resin into three-dimensionally reinforced textile preforms can be a costly and difficult operation. Alternatively, using polymer in the solid form, grinding it into a powder, and then depositing it onto a carbon fiber tow prior to making a textile preform is a viable method for the production of complex textile shapes. The powder-coated towpreg yarn is stable, needs no refrigeration, contains no solvents and is easy to process into various woven and braided preforms for later consolidation into composite structures. NASA's Advanced Composites Technology (ACT) program has provided an avenue for developing the technology by which advanced resins and their powder-coated preforms may be used in aircraft structures. Two-dimensional braiding and weaving studies using powder-coated towpreg have been conducted to determine the effect of resin content, towpreg size and twist on textile composite properties. Studies have been made to customize the towpreg to reduce friction and bulk factor. Processing parameters have been determined for three epoxy resin systems on eight-harness satin fabric, and on more advanced 3-D preform architectures for the downselected resin system. Processing effects and the resultant mechanical properties of these textile composites will be presented and compared.

Product reliability and thin-film photovoltaics

NASA Astrophysics Data System (ADS)

Gaston, Ryan; Feist, Rebekah; Yeung, Simon; Hus, Mike; Bernius, Mark; Langlois, Marc; Bury, Scott; Granata, Jennifer; Quintana, Michael; Carlson, Carl; Sarakakis, Georgios; Ogden, Douglas; Mettas, Adamantios

2009-08-01

Despite significant growth in photovoltaics (PV) over the last few years, only approximately 1.07 billion kWhr of electricity is estimated to have been generated from PV in the US during 2008, or 0.27% of total electrical generation. PV market penetration is set for a paradigm shift, as fluctuating hydrocarbon prices and an acknowledgement of the environmental impacts associated with their use, combined with breakthrough new PV technologies, such as thin-film and BIPV, are driving the cost of energy generated with PV to parity or cost advantage versus more traditional forms of energy generation. In addition to reaching cost parity with grid supplied power, a key to the long-term success of PV as a viable energy alternative is the reliability of systems in the field. New technologies may or may not have the same failure modes as previous technologies. Reliability testing and product lifetime issues continue to be one of the key bottlenecks in the rapid commercialization of PV technologies today. In this paper, we highlight the critical need for moving away from relying on traditional qualification and safety tests as a measure of reliability and focus instead on designing for reliability and its integration into the product development process. A drive towards quantitative predictive accelerated testing is emphasized and an industrial collaboration model addressing reliability challenges is proposed.

Microalgae Feedstocks for Aviation Fuels

DOE Office of Scientific and Technical Information (OSTI.GOV)

Wigmosta, Mark S.; Coleman, Andre; Venteris, Erik

There is significant global interest in developing, testing, and using alternative jet fuels for both commercial and military use in an effort to create a sustainable and stable fuel supply while reducing greenhouse gas emissions. Currently, the aviation industry is entirely dependent on a finite-supply of petroleum based fuel sourced in part by politically and economically unstable regions of the world. Commercial jet fuel use within the contiguous United States (CONUS) was 17.8 billion gallons per year (BGY) in 2009, while jet fuel use in 2010 by the U.S. Air Force (USAF), Navy, and Army was 1.5 BGY, 0.6 BGY,more » and 0.8 BGY, respectively (Carter et al., 2011). U.S. commercial and military aviation sectors have set ambitious near-term alternative fuel and environmental performance targets. This includes a tentative Federal Aviation Administration (FAA) goal of 1 BGY alternative fuel use by commercial aircraft by 2018. The USAF has set a target of 50% for USAF domestic aviation via alternative fuels by 2016 (0.73 BGY), and 50% of the Navy’s total energy consumption afloat (0.3 BGY) will come from alternative fuels by 2020 (Carter et al., 2011). If these targets become policy, at least 2 BGY of domestically-produced alternative jet fuel will be required by 2020. The Energy Independence and Security Act (EISA) of 2007 established production requirements for domestic alternative fuels under the Renewable Fuel Standard (RFS). For example, 36 billion gallons of renewable fuel must be produced by 2022, of which 21 billion gallons shall be advanced biofuels. EISA defines advanced biofuels as non-corn starch derived biofuels having lifecycle greenhouse gas emissions 50% lower than gasoline. There a number of potential fuel pathways for meeting the RFS. One of these is biomass-based diesel, including jet fuel (Schnepf and Yacobucci, 2013). The U.S. Department of Energy (DOE) Bioenergy Technologies Office (BETO) has a stated goal in its 2013 Multi-Year Program Plan (USDOE, 2013) to support the RFS through development of “…commercially viable biomass utilization technologies to encourage the creation of a new domestic bioenergy industry…”. BETO has also recognized the potential for aviation biofuels to support the bioenergy industry, seeing drop-in bio-based jet fuels one of the viable alternatives for the aviation industry and the military to meet their ambitious near-term GHG reduction targets (USDOE, 2014). One of the important Multi-year Program Plan Targets (USDOE, 2013) is to establish feedstock resource assessment models to evaluate the geographic, economic, quality and environmental criteria for which 20 million metric tons of ash free dry weight (AFDW) algal biomass can be produced by 2022. Toward meeting the EISA requirements, algal biofuels may offer a number of advantages. They can produce a range of biofuel feedstocks suitable for diesel and aviation fuels. Microalgae, on a strain-specific basis, can be cultivated using impaired water including saline, and/or brackish pumped groundwater or seawater, treated industrial wastewater, municipal sewage effluent, and produced water generated from oil and gas drilling operations. Additionally, microalgae require nitrogen and phosphates as essential nutrients and could provide water treatment co-benefits to municipalities, industry, and the environment.« less

Efficacy of Diverse Antiparasitic Treatments for Cysticercosis in the Pig Model

PubMed Central

Gonzalez, Armando E.; Bustos, Javier A.; Jimenez, Juan A.; Rodriguez, Mary L.; Ramirez, Mercy G.; Gilman, Robert H.; Garcia, Hector H.

2012-01-01

Taenia solium cysticercosis infects pigs and humans. Because antiparasitic treatment for human cysticercosis has sub-optimal efficacy, alternative regimes are needed. Seven antiparasitic regimens were tested in 42 naturally infected pigs with cysticercosis, and compared with prednisone alone (n = 6) or no treatment (n = 6). The numbers of viable cysts in muscles and in the brain were examined after necropsy and were significantly decreased in pigs receiving combined albendazole plus praziquantel, albendazole alone, or oxfendazole. Pigs receiving praziquantel alone and nitazoxanide had numerous surviving cysts. Control (untreated) pigs and prednisone-treated pigs had many more viable cysts, suggesting no effect. Combined albendazole plus praziquantel, and oxfendazole, showed a strong cysticidal effect and provide suitable alternative treatments to be further explored for their use for treatment of human neurocysticercosis. PMID:22855760

Customizing microarrays for neuroscience drug discovery.

PubMed

Girgenti, Matthew J; Newton, Samuel S

2007-08-01

Microarray-based gene profiling has become the centerpiece of gene expression studies in the biological sciences. The ability to now interrogate the entire genome using a single chip demonstrates the progress in technology and instrumentation that has been made over the last two decades. Although this unbiased approach provides researchers with an immense quantity of data, obtaining meaningful insight is not possible without intensive data analysis and processing. Custom developed arrays have emerged as a viable and attractive alternative that can take advantage of this robust technology and tailor it to suit the needs and requirements of individual investigations. The ability to simplify data analysis, reduce noise and carefully optimize experimental conditions makes it a suitable tool that can be effectively utilized in neuroscience drug discovery efforts. Furthermore, incorporating recent advancements in fine focusing gene profiling to include specific cellular phenotypes can help resolve the complex cellular heterogeneity of the brain. This review surveys the use of microarray technology in neuroscience paying special attention to customized arrays and their potential in drug discovery. Novel applications of microarrays and ancillary techniques, such as laser microdissection, FAC sorting and RNA amplification, have also been discussed. The notion that a hypothesis-driven approach can be integrated into drug development programs is highlighted.

Architecture for Survivable System Processing (ASSP)

NASA Astrophysics Data System (ADS)

Wood, Richard J.

1991-11-01

The Architecture for Survivable System Processing (ASSP) Program is a multi-phase effort to implement Department of Defense (DOD) and commercially developed high-tech hardware, software, and architectures for reliable space avionics and ground based systems. System configuration options provide processing capabilities to address Time Dependent Processing (TDP), Object Dependent Processing (ODP), and Mission Dependent Processing (MDP) requirements through Open System Architecture (OSA) alternatives that allow for the enhancement, incorporation, and capitalization of a broad range of development assets. High technology developments in hardware, software, and networking models, address technology challenges of long processor life times, fault tolerance, reliability, throughput, memories, radiation hardening, size, weight, power (SWAP) and security. Hardware and software design, development, and implementation focus on the interconnectivity/interoperability of an open system architecture and is being developed to apply new technology into practical OSA components. To insure for widely acceptable architecture capable of interfacing with various commercial and military components, this program provides for regular interactions with standardization working groups (e.g.) the International Standards Organization (ISO), American National Standards Institute (ANSI), Society of Automotive Engineers (SAE), and Institute of Electrical and Electronic Engineers (IEEE). Selection of a viable open architecture is based on the widely accepted standards that implement the ISO/OSI Reference Model.

Architecture for Survivable System Processing (ASSP)

NASA Technical Reports Server (NTRS)

Wood, Richard J.

1991-01-01

The Architecture for Survivable System Processing (ASSP) Program is a multi-phase effort to implement Department of Defense (DOD) and commercially developed high-tech hardware, software, and architectures for reliable space avionics and ground based systems. System configuration options provide processing capabilities to address Time Dependent Processing (TDP), Object Dependent Processing (ODP), and Mission Dependent Processing (MDP) requirements through Open System Architecture (OSA) alternatives that allow for the enhancement, incorporation, and capitalization of a broad range of development assets. High technology developments in hardware, software, and networking models, address technology challenges of long processor life times, fault tolerance, reliability, throughput, memories, radiation hardening, size, weight, power (SWAP) and security. Hardware and software design, development, and implementation focus on the interconnectivity/interoperability of an open system architecture and is being developed to apply new technology into practical OSA components. To insure for widely acceptable architecture capable of interfacing with various commercial and military components, this program provides for regular interactions with standardization working groups (e.g.) the International Standards Organization (ISO), American National Standards Institute (ANSI), Society of Automotive Engineers (SAE), and Institute of Electrical and Electronic Engineers (IEEE). Selection of a viable open architecture is based on the widely accepted standards that implement the ISO/OSI Reference Model.

The Economics of Transcatheter Valve Interventions.

PubMed

Sud, Maneesh; Tam, Derrick Y; Wijeysundera, Harindra C

2017-09-01

A subset of patients who require correction of a stenotic or incompetent valve are deemed to be at excessive surgical risk, which precludes surgical repair or replacement. Transcatheter valve interventions are viable alternatives in these patients. However, these technologies are costly, and in the setting of a constrained Canadian health care budget, economic value is an important consideration to allow for fair allocation of scarce resources. Accordingly, we review the economic literature on transcatheter valve interventions, targeting a general audience. Our specific goals are highlighting how best to interpret these studies and discuss the implications of these technologies on the Canadian health care system. Transcatheter aortic valve replacement (TAVR) is a cost-effective alternative for inoperable patients who otherwise would receive medical therapy. When compared with surgical aortic valve replacement (SAVR), TAVR is associated with significant reductions in postprocedure hospital resource use, which offsets the substantially higher cost of the TAVR valve system relative to SAVR valves. Although cost-effectiveness estimates for TAVR in high-risk operable candidates vary widely across studies, based on contemporary data from the perspective of the Canadian health care system, TAVR is likely to provide economic value. Recent studies suggest that when compared with medical therapy for severe degenerative mitral regurgitation, the MitraClip (Abbott, Abbott Park, IL) may offer economic value in high-risk patients; however, in the absence of randomized controlled trials, this is speculative. Nonetheless, these transcatheter technologies represent a paradigm shift in the management of valvular disease; their dissemination will have substantial impact in cardiovascular care delivery. Copyright © 2017 Canadian Cardiovascular Society. Published by Elsevier Inc. All rights reserved.

Development Status of PEM Non-Flow-Through Fuel Cell System Technology for NASA Applications

NASA Technical Reports Server (NTRS)

Hoberecht, Mark A.; Jakupca, Ian J.

2011-01-01

Today s widespread development of proton-exchange-membrane (PEM) fuel cell technology for commercial users owes its existence to NASA, where fuel cell technology saw its first applications. Beginning with the early Gemini and Apollo programs, and continuing to this day with the Shuttle Orbiter program, fuel cells have been a primary source of electrical power for many NASA missions. This is particularly true for manned missions, where astronauts are able to make use of the by-product of the fuel cell reaction, potable water. But fuel cells also offer advantages for unmanned missions, specifically when power requirements exceed several hundred watts and primary batteries are not a viable alternative. In recent years, NASA s Exploration Technology Development Program (ETDP) funded the development of fuel cell technology for applications that provide both primary power and regenerative fuel cell energy storage for planned Exploration missions that involved a return to the moon. Under this program, the Altair Lunar Lander was a mission requiring fuel cell primary power. There were also various Lunar Surface System applications requiring regenerative fuel cell energy storage, in which a fuel cell and electrolyzer combine to form an energy storage system with hydrogen, oxygen, and water as common reactants. Examples of these systems include habitat modules and large rovers. In FY11, the ETDP has been replaced by the Enabling Technology Development and Demonstration Program (ETDDP), with many of the same technology goals and requirements applied against NASA s revised Exploration portfolio.

Learner-centred mathematics and statistics education using netbook tablet PCs

NASA Astrophysics Data System (ADS)

Loch, Birgit; Galligan, Linda; Hobohm, Carola; McDonald, Christine

2011-10-01

Tablet technology has been shown to support learner-centred mathematics education when this technology is available to both the lecturer and the students. However, cost is often the barrier to students' use of tablet PCs for their university studies. This article argues that more affordable netbook PCs with tablet capabilities can be viable alternatives to full-sized tablet PCs to enhance active and collaborative learning in mathematics and statistics. For a whole teaching semester, netbook tablet PCs were given to volunteer students from two different cohorts. Students were enrolled in nursing mathematics or introductory statistics in non-mathematics majors at an Australian university. The aims were to gauge the suitability of this technology and to identify what active and collaborative learning emerged in these first-year classes. While the netbook tablet PCs were actively promoted in their tutorials, of additional interest was students' use of the technology for any aspect of their studies both inside and outside the classroom. The outcome of this study was to inform a university decision to provide inexpensive tablet technology to larger cohorts of students. The results highlight different approaches required in the mathematics and statistics classes to achieve collaborative and active learning facilitated through the technology. Environmental variables such as the tutor, student, learning space, availability of other technologies and subject content had an impact on the nature of learning. While learner-centred education can be facilitated by inexpensive netbook tablet PCs, we caution that the savings may come at the expense of computing power.

Hypersonic airbreathing vehicle conceptual design (focus on aero-space plane)

NASA Technical Reports Server (NTRS)

Hunt, James L.; Martin, John G.

1989-01-01

The airbreathing single stage to orbit (SSTO) vehicle design environment is variable-rich, intricately networked and sensitivity intensive. As such, it represents a tremondous technology challenge. Creating a viable design will require sophisticated configuration/synthesis and the synergistic integration of advanced technologies across the discipline spectrum. In design exercises, reductions in the fuel weight-fraction requirements projected for an orbital vehicle concept can result from improvements in aerodynamics/controls, propulsion efficiencies and trajectory optimization; also, gains in the fuel weight-fraction achievable for such a concept can result from improvements in structural design, heat management techniques, and material properties. As these technology advances take place, closure on a viable vehicle design will be realizable.

Towards viable drinking water services.

PubMed

Hukka, J J; Katko, T S

1997-01-01

This article offers a framework for developing viable drinking water services and institutional development in developing countries. The framework evolved from the authors' research and field experience in transition and developing economies. Viability is related to operative technology, appropriate organizations, and adequate cost recovery within the context of water resources, human and economic resources, sociocultural conditions, and other constraints. The ability of institutions to solve the problems of coordination and production depends upon player motivation, the complexity of the environment, and the ability of the players to control the environment. Third party enforcement of agreements are essential to reduce gains from opportunism, cheating, and shirking. Empirical research finds that per capita water production costs are 4 times higher in centralized systems and lowest in decentralized systems with coordination from a central party. Three-tiered systems of governments, regulators, and service providers are recommended. Management options must be consumer driven. The worst case scenario is consumer's reliance on vending and reselling with no alternative source of supply. Policies should have a strong focus on institutional reforms in the water sector, the development of a consumer driven water sector, facilitation of appropriate private-public partnerships, sound management of existing capital assets, a system for building viability into national strategies for the water sector, and financially self-sufficient and consumer responsible water supply organizations.

Improved Performance in Mammalian Cell Perfusion Cultures by Growth Inhibition.

PubMed

Wolf, Moritz K F; Closet, Aurélie; Bzowska, Monika; Bielser, Jean-Marc; Souquet, Jonathan; Broly, Hervé; Morbidelli, Massimo

2018-05-21

Mammalian cell perfusion cultures represent a promising alternative to the current fed-batch technology for the production of various biopharmaceuticals. Long-term operation at a fixed viable cell density (VCD) requires a viable culture and a constant removal of excessive cells. Product loss in the cell removing bleed stream deteriorates the process yield. In this study, the authors investigate the use of chemical and environmental growth inhibition on culture performance by either adding valeric acid (VA) to the production media or by reducing the culture temperature (33.0 °C) with respect to control conditions (36.5 °C, no VA). Low temperature significantly reduces cellular growth, thus, resulting in lower bleed rates accompanied by a reduced product loss of 11% compared to 26% under control conditions. Additionally, the cell specific productivity of the target protein improves and maintained stable leading to media savings per mass of product. VA shows initially an inhibitory effect on cellular growth. However, cells seemed to adapt to the presence of the inhibitor resulting in a recovery of the cellular growth. Cell cycle and Western blot analyses support the observed results. This work underlines the role of temperature as a key operating variable for the optimization of perfusion cultures. © 2018 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

An economic analysis of alternative paving materials

NASA Astrophysics Data System (ADS)

Mustain, J. L.

1982-12-01

The purpose of this paper is to present a means for economic analysis of alternative equivalent pavement designs, considering such factors as initial construction cost, annual maintenance cost, salvage value and the various intangibles which occur during the analysis period. Having established a means of economic comparison, it is then the intent of this paper to show that Portland Cement Concrete has been and is a viable pavement alternative and ought to receive due consideration in the military construction program.

Designing Opportunities for Transformation with Emerging Technologies

ERIC Educational Resources Information Center

Veletsianos, George

2011-01-01

In this article, the author argues that technology use in education has focused on combating instructional problems and inefficiencies. While technology use for such purposes is viable and important, the author proposes that practitioners and researchers in this field utilize emerging technologies as a means to provide opportunities for personally…

"I'm not strong enough; I'm not good enough. I can't do this, I'm failing"- A qualitative study of low-socioeconomic status smokers' experiences with accesssing cessation support and the role for alternative technology-based support.

PubMed

Boland, Veronica C; Mattick, Richard P; McRobbie, Hayden; Siahpush, Mohammad; Courtney, Ryan J

2017-11-13

The social gradient in smoking rates persist with an overrepresentation of smoking and its associated harms concentrated within lower socioeconomic status (SES) populations. Low-SES smokers are motivated to quit but face multiple barriers when engaging a quit attempt. An understanding of the current treatment service model from the perspectives of treatment-seeking low-SES smokers is needed to inform the design of alternative smoking cessation support services tailored to the needs of low-SES populations. This qualitative study aimed to: i) explore low-SES smokers' recent quitting experiences; ii) assess factors that impact treatment engagement; and iii) determine the acceptability and feasibility of alternative approaches to smoking cessation. Low-SES participants (n = 24) previously enrolled in a smoking cessation RCT participated in either a semi-structured focus group or in-depth telephone interview. Data was obtained and analysed using thematic analysis from October 2015 to June 2016. Analysis was deductive from the interview guide and supplemented inductively. Participants expressed feelings of guilt and shame around their smoking behaviour and experienced stigmatisation for their smoking. Guilt, shame, and stigmatisation negatively impacted treatment seeking behaviours with most avoiding current quit services. Costs of pharmacotherapy and treatment adherence were commonly cited barriers to treatment success. Electronic-cigarettes were perceived to be unsafe due to uncertainty on their legal status and regulatory restrictions. Technology-based text-messaging quit support was endorsed as a more favourable alternative compared to existing behavioural treatment services. Stigmatisation was commonly endorsed and acted as an impediment to current treatment utilisation. Electronic-cigarettes may present a viable harm reduction alternative, but their likely uptake in socioeconomically disadvantaged groups in Australia is limited by smokers' uncertainty about their regulation and legality. Mobile phone based cessation support may provide an alternative to telephone counselling and overcome the stigmatisation low-SES smokers face while trying to quit.

The use of distributed temperature sensing technology for monitoring wildland fire intensity and distribution.

NASA Astrophysics Data System (ADS)

Ochoa, C. G.; Cram, D.; Hatch, C. E.; Tyler, S. W.

2014-12-01

Distributed temperature sensing (DTS) technology offers a viable alternative for accurately measuring wildland fire intensity and distribution in real time applications. We conducted an experiment to test the use of DTS as an alternative technology to monitor prescribed fire temperatures in real time and across a broad spatial scale. The custom fiber-optic cable consisted of three fiber optic lines buffered by polyamide, copper, and polyvinyl chloride, respectively, each armored in a stainless steel tube backfilled with Nitrogen gas. The 150 m long cable was deployed in three different 20 by 26 m experimental plots of short-grass rangeland in central New Mexico. Cable was arranged to maximize coverage of the experimental plots and allow cross-comparison between two main parallel straight-line sections approximately 8 m apart. A DTS system recorded fire temperatures every three seconds and integrated every one meter. A series of five thermocouples attached to a datalogger were placed at selected locations along the cable and also recorded temperature data every three seconds on each fiber. Results indicate that in general there is good agreement between thermocouple-measured and DTS-measured temperatures. A close match in temperature between DTS and thermocouples was particularly observed during the rising limb but not so much during the decline. The metal armoring of the fiber-optic cable remained hot longer than the thermocouples after the flames had passed. The relatively short-duration, high-intensity, prescribed burn fire in each plot resulted in temperatures reaching up to 450 degrees Celsius. In addition, DTS data allow for illustration of the irregular nature of flame speed and travel path across the rangeland grasses, a phenomenon that was impossible to quantify without the use of this tool. This study adds to the understanding of using DTS as a new alternative tool for better characterizing wildland fire intensity, distribution and travel patterns, and establishes the baseline for expanding these test plot results to larger spatial scales.

Can I Choose to Have Grit? Non-Cognitive Skills, Behavior, and School Choice

ERIC Educational Resources Information Center

Nichols, Malachi

2017-01-01

With the introduction of school choice as a viable option of school reform, researchers have begun to look beyond academic achievement to the effects of choice on alternative outcomes. Recently, non-cognitive skills and behavior stand at the front of those alternative outcomes. From the most up to date relevant literature it appears that school…

Stability, antimicrobial activity, and effect of nisin on the physico-chemical properties of fruit juices.

PubMed

de Oliveira Junior, Adelson Alves; de Araújo Couto, Hyrla Grazielle Silva; Barbosa, Ana Andréa Teixeira; Carnelossi, Marcelo Augusto Guitierrez; de Moura, Tatiana Rodrigues

2015-10-15

Heat processing is the most commonly used hurdle for inactivating microorganisms in fruit juices. However, this preservation method could interfere with the organoleptic characteristics of the product. Alternative methods have been proposed and bacteriocins such as nisin are potential candidates. However, the approval of bacteriocins as food additives is limited, especially in foods from vegetal origin. We aimed to verify the stability, the effect on physico-chemical properties, and the antimicrobial activity of nisin in different fruit juices. Nisin remained stable in fruit juices (cashew, soursop, peach, mango, passion fruit, orange, guava, and cupuassu) for at least 30 days at room or refrigerated temperature and did not cause any significant alterations in the physico-chemical characteristics of the juices. Besides, nisin favored the preservation of vitamin C content in juices. The antimicrobial activity of nisin was tested against Alicyclobacillus acidoterrestris, Bacillus cereus, Staphylococcus aureus and Listeria monocytogenes in cashew, soursop, peach, and mango juices. Nisin caused a 4-log reduction in viable cells of A. acidoterrestris in soursop, peach, and mango juices after 8h of incubation, and no viable cells were detected in cashew juices. After 24h of incubation in the presence of nisin, no viable cells were detected, independently of the juices. To S. aureus, at 24h of incubation in the presence of nisin, viable cells were only detected in mango juices, representing a 4-log decrease as compared with the control treatment. The number of viable cells of B. cereus at 24h of incubation in the presence of nisin represented at least a 4-log decrease compared to the control treatment. When the antimicrobial activity of nisin was tested against L. monocytogenes in cashew and soursop juices, no reduction in the viable cell number was observed compared to the control treatment after 24h of incubation. Viable cells were four and six times less than in the control treatment, in peach and mango juices respectively. The most sensitive microorganism to nisin was A. acidoterrestris and the least sensitive was L. monocytogenes. Still, a reduction of up to 90% of viable cells was observed in peach and mango juices inoculated with L. monocytogenes. These results indicate that the use of nisin could be an alternative in fruit juice processing. Copyright © 2015 Elsevier B.V. All rights reserved.

Quantum simulation of quantum field theory using continuous variables

DOE PAGES

Marshall, Kevin; Pooser, Raphael C.; Siopsis, George; ...

2015-12-14

Much progress has been made in the field of quantum computing using continuous variables over the last couple of years. This includes the generation of extremely large entangled cluster states (10,000 modes, in fact) as well as a fault tolerant architecture. This has lead to the point that continuous-variable quantum computing can indeed be thought of as a viable alternative for universal quantum computing. With that in mind, we present a new algorithm for continuous-variable quantum computers which gives an exponential speedup over the best known classical methods. Specifically, this relates to efficiently calculating the scattering amplitudes in scalar bosonicmore » quantum field theory, a problem that is known to be hard using a classical computer. Thus, we give an experimental implementation based on cluster states that is feasible with today's technology.« less

Quantum simulation of quantum field theory using continuous variables

DOE Office of Scientific and Technical Information (OSTI.GOV)

Marshall, Kevin; Pooser, Raphael C.; Siopsis, George

Much progress has been made in the field of quantum computing using continuous variables over the last couple of years. This includes the generation of extremely large entangled cluster states (10,000 modes, in fact) as well as a fault tolerant architecture. This has lead to the point that continuous-variable quantum computing can indeed be thought of as a viable alternative for universal quantum computing. With that in mind, we present a new algorithm for continuous-variable quantum computers which gives an exponential speedup over the best known classical methods. Specifically, this relates to efficiently calculating the scattering amplitudes in scalar bosonicmore » quantum field theory, a problem that is known to be hard using a classical computer. Thus, we give an experimental implementation based on cluster states that is feasible with today's technology.« less

Contrast medium administration and image acquisition parameters in renal CT angiography: what radiologists need to know

PubMed Central

Saade, Charbel; Deeb, Ibrahim Alsheikh; Mohamad, Maha; Al-Mohiy, Hussain; El-Merhi, Fadi

2016-01-01

Over the last decade, exponential advances in computed tomography (CT) technology have resulted in improved spatial and temporal resolution. Faster image acquisition enabled renal CT angiography to become a viable and effective noninvasive alternative in diagnosing renal vascular pathologies. However, with these advances, new challenges in contrast media administration have emerged. Poor synchronization between scanner and contrast media administration have reduced the consistency in image quality with poor spatial and contrast resolution. Comprehensive understanding of contrast media dynamics is essential in the design and implementation of contrast administration and image acquisition protocols. This review includes an overview of the parameters affecting renal artery opacification and current protocol strategies to achieve optimal image quality during renal CT angiography with iodinated contrast media, with current safety issues highlighted. PMID:26728701

Wind tunnel tests of the dynamic characteristics of the fluidic rudder

NASA Technical Reports Server (NTRS)

Belsterling, C. A.

1976-01-01

The fourth phase is given of a continuing program to develop the means to stabilize and control aircraft without moving parts or a separate source of power. Previous phases have demonstrated the feasibility of (1) generating adequate control forces on a standard airfoil, (2) controlling those forces with a fluidic amplifier and (3) cascading non-vented fluidic amplifiers operating on ram air supply pressure. The foremost objectives of the fourth phase covered under Part I of this report were to demonstrate a complete force-control system in a wind tunnel environment and to measure its static and dynamic control characteristics. Secondary objectives, covered under Part II, were to evaluate alternate configurations for lift control. The results demonstrate an overall response time of 150 msec, confirming this technology as a viable means for implementing low-cost reliable flight control systems.

R744 ejector technology future perspectives

NASA Astrophysics Data System (ADS)

Hafner, Armin; Banasiak, Krzysztof

2016-09-01

Carbon Dioxide, CO2 (R744) was one of the first commonly applied working fluids in the infancy of refrigeration more than 100 years ago. In contrast to ammonia it mainly disappeared after the first generation of synthetic refrigerants have been introduced to the market after 1930. One reason was that the transition from low-rpm belt driven compressors towards the direct electrical motor driven compressors (50-60 Hz) was not performed for CO2 compressors before the revival introduced by Gustav Lorentzen in the 90is of last century. Since 1988 an enormous R & D effort has been made to further develop CO2 refrigeration technology in spite of the opposition from the chemical industry. Today CO2 refrigeration and heat pumping technologies are accepted as viable and sustainable alternatives for several applications like commercial refrigeration, transport refrigeration, vehicle air conditioning & heat pumping, domestic hot water heat pumps and industrial applications. For some applications, the current threshold to introduce R744 technology can be overcome when the system design takes into account the advantage of the thermo dynamical- and fluid properties of CO2. I.e. the system is designed for transcritical operation with all it pros and cons and takes into consideration how to minimize the losses, and to apply the normally lost expansion work. Shortcut-designs, i.e. drop in solutions, just replacing the H(C)FC refrigeration unit with an CO2 systems adapted for higher system pressures will not result in energy efficient products. CO2 systems do offer the advantage of enabling flooded evaporators supported with adapted ejector technology. These units offer high system performances at low temperature differences and show low temperature air mal-distributions across evaporators. This work gives an overview for the development possibilities for several applications during the next years. Resulting in a further market share increase of CO2 refrigeration and heat pump systems, as energy efficient alternatives to current systems not applying natural working fluids.

Guest Comment: Universal Language Requirement.

ERIC Educational Resources Information Center

Sherwood, Bruce Arne

1979-01-01

Explains that reading English among Scientists is almost universal, however, there are enormous problems with spoken English. Advocates the use of Esperanto as a viable alternative, and as a language requirement for graduate work. (GA)

Building Student Awareness of Societal Decision-Making Challenges about Energy through the Study of Earth System Data and Innovations in Energy-Related Materials Research

NASA Astrophysics Data System (ADS)

Zalles, D. R.; Acker, J. G.; Berding, M.

2014-12-01

Energy literacy requires knowledge about the trade-offs inherent in energy alternatives, about how humans use energy and have choices in how much energy to use, and about what changes to the Earth system are occurring from energy uses. It also requires collaborative decision-making skills coupled with awareness about what values we bring to the table as we negotiate solutions that serve both personal needs and the common good. Coming up with a notion of the common good requires delineating how environmental crises occurring in other parts of the world compare to our own. We also need to understand criteria for judging what might be viable solutions. This presentation describes work that SRI International is carrying out to meet these awareness-building needs. SRI educational researchers created a curriculum that immerses students in studying regional climate change data about California in comparison to global climate change. Students ponder solution energy-related strategies and impact analyses. The curriculum will be described, as will a collaboration between SRI educational researchers and materials scientists. The scientists are designing and testing technologies for producing biofuels and solar power, and for sequestering carbon from coal fired power plants. As they apply principles of science and engineering to test materials intended to meet these energy challenges, they understand that even if the tests prove successful, if there is not economic feasibility or environmental advantage, the technology may not stand as a viable solution. This educator-scientist team is using the Essential Energy Principles and Next Generation Science Standards to articulate milestones along a trajectory of energy learning. The trajectory starts with simple understandings of what energy is and what constitute our energy challenges. It ends with more the types of more sophisticated understandings needed for designing and testing energy technology solutions.

Microalgal biomass production pathways: evaluation of life cycle environmental impacts.

PubMed

Zaimes, George G; Khanna, Vikas

2013-06-20

Microalgae are touted as an attractive alternative to traditional forms of biomass for biofuel production, due to high productivity, ability to be cultivated on marginal lands, and potential to utilize carbon dioxide (CO2) from industrial flue gas. This work examines the fossil energy return on investment (EROIfossil), greenhouse gas (GHG) emissions, and direct Water Demands (WD) of producing dried algal biomass through the cultivation of microalgae in Open Raceway Ponds (ORP) for 21 geographic locations in the contiguous United States (U.S.). For each location, comprehensive life cycle assessment (LCA) is performed for multiple microalgal biomass production pathways, consisting of a combination of cultivation and harvesting options. Results indicate that the EROIfossil for microalgae biomass vary from 0.38 to 1.08 with life cycle GHG emissions of -46.2 to 48.9 (g CO2 eq/MJ-biomass) and direct WDs of 20.8 to 38.8 (Liters/MJ-biomass) over the range of scenarios analyzed. Further anaylsis reveals that the EROIfossil for production pathways is relatively location invariant, and that algae's life cycle energy balance and GHG impacts are highly dependent on cultivation and harvesting parameters. Contrarily, algae's direct water demands were found to be highly sensitive to geographic location, and thus may be a constraining factor in sustainable algal-derived biofuel production. Additionally, scenarios with promising EROIfossil and GHG emissions profiles are plagued with high technological uncertainty. Given the high variability in microalgae's energy and environmental performance, careful evaluation of the algae-to-fuel supply chain is necessary to ensure the long-term sustainability of emerging algal biofuel systems. Alternative production scenarios and technologies may have the potential to reduce the critical demands of biomass production, and should be considered to make algae a viable and more efficient biofuel alternative.

NASA helicopter transmission system technology program

NASA Technical Reports Server (NTRS)

Zaretsky, E. V.

1983-01-01

The purpose of the NASA Helicopter Transmission System Technology Program is to improve specific mechanical components and the technology for combining these into advanced drive systems to make helicopters more viable and cost competitive for commerical applications. The history, goals, and elements of the program are discussed.

Coding and Modulation for LMDS and Analysis of the LMDS Channel

PubMed Central

Håkegård, Jan Erik

2000-01-01

Local Multipoint Distribution Service (LMDS) has the potential to become a viable alternative to coaxial cable, fiber and other wired and wireless technologies providing “last mile” communication services. A major obstacle, however, is the high equipment cost. While for example cable modems supporting two-way services are available for $200 to $300, LMDS modem providing similar services will cost over $1000. The major cost driver of LMDS equipment is the radio frequency (RF) unit, as Ka-band technology still is quite expensive. The modem design must minimize the overall architecture cost, and low-cost modems requiring an expensive architecture should not be used. The channel characteristics of LMDS systems are very different from those of fiber, coaxial cable, and lower frequency wireless links, major channel impairments being non-linear high power amplifier (HPA), high phase noise and high co-channel interference. Modems should therefore be developed specifically for LMDS systems. This report deals with the choice of coding and modulation schemes, the LMDS channel, and how the channel impairments should be overcome by digital signal processing algorithms. PMID:27551634

Unique CAD/CAM three-quarter crown restoration of a central incisor: a case report.

PubMed

Goldberg, Marvin B; Siegel, Sharon C; Rezakani, Niloufar

2013-07-01

Computer-aided design and computer-aided manufacturing (CAD/CAM) dentistry has been in use for more than 2 decades. Recent improvements in this technology have made CAD/CAM restorations a viable alternative for routine dental care. This technology is being taught in dental schools to prepare students for contemporary dental practice and is particularly useful in unique restorative situations that allow conservation of tooth structure. This case report describes the restoration of a central incisor that was previously restored with an unesthetic three-quarter gold crown. The tooth exhibited recurrent caries and an unaffected labial wall of supported enamel. A CAD/CAM three-quarter crown was planned to conserve tooth structure. After preparation, the tooth was scanned for a CAD/CAM crown in order to fabricate a ceramic restoration, which was then milled and bonded, producing an esthetic result. Typically, in cases of esthetic enhancement, a labial laminate restoration is fabricated, but in this situation, a different approach was necessary to make a design for the lingual surface of an anterior tooth.

Smartphone application for emergency signal detection.

PubMed

Figueiredo, Isabel N; Leal, Carlos; Pinto, Luís; Bolito, Jason; Lemos, André

2016-09-01

Currently, a number of studies focus on the study and design of new healthcare technologies to improve elderly health and quality of life. Taking advantage of the popularity, portability, and inherent technology of smartphones, we present an emergency application for smartphones, designated as knock-to-panic (KTP). This innovative and novel system enables users to simply hit their devices in order to send an alarm signal to an emergency service. This application is a complete and autonomous emergency system, and can provide an economic, reliable, and unobtrusive method for elderly monitoring or safety protection. Moreover, the simple and fast activation of KTP makes it a viable and potentially superior alternative to traditional ambient assisted living emergency calls. Furthermore, KTP can be further extended to the general population as well and not just be limited for elderly persons. The proposed method is a threshold-based algorithm and is designed to require a low battery power consumption. The evaluation of the performance of the algorithm in collected data indicates that both sensitivity and specificity are above 90%. Copyright © 2016 IPEM. Published by Elsevier Ltd. All rights reserved.

Energy scavenging sources for biomedical sensors.

PubMed

Romero, E; Warrington, R O; Neuman, M R

2009-09-01

Energy scavenging has increasingly become an interesting option for powering electronic devices because of the almost infinite lifetime and the non-dependence on fuels for energy generation. Moreover, the rise of wireless technologies promises new applications in medical monitoring systems, but these still face limitations due to battery lifetime and size. A trade-off of these two factors has typically governed the size, useful life and capabilities of an autonomous system. Energy generation from sources such as motion, light and temperature gradients has been established as commercially viable alternatives to batteries for human-powered flashlights, solar calculators, radio receivers and thermal-powered wristwatches, among others. Research on energy harvesting from human activities has also addressed the feasibility of powering wearable or implantable systems. Biomedical sensors can take advantage of human-based activities as the energy source for energy scavengers. This review describes the state of the art of energy scavenging technologies for powering sensors and instrumentation of physiological variables. After a short description of the human power and the energy generation limits, the different transduction mechanisms, recent developments and challenges faced are reviewed and discussed.

The Science and Ethics of Induced Pluripotency: What Will Become of Embryonic Stem Cells?

PubMed Central

Zacharias, David G.; Nelson, Timothy J.; Mueller, Paul S.; Hook, C. Christopher

2011-01-01

For over a decade, the field of stem cell research has advanced tremendously and gained new attention in light of novel insights and emerging developments for regenerative medicine. Invariably, multiple considerations come into play, and clinicians and researchers must weigh the benefits of certain stem cell platforms against the costs they incur. Notably, human embryonic stem (hES) cell research has been a source of continued debate, leading to differing policies and regulations worldwide. This article briefly reviews current stem cell platforms, looking specifically at the two existing pluripotent lines available for potential therapeutic applications: hES cells and induced pluripotent stem (iPS) cells. We submit iPS technology as a viable and possibly superior alternative for future medical and research endeavors as it obviates many ethical and resource-related concerns posed by hES cells while prospectively matching their potential for scientific use. However, while the clinical realities of iPS cells appear promising, we must recognize the current limitations of this technology, avoid hype, and articulate ethically acceptable medical and scientific goals. PMID:21719620

Protein and oil composition predictions of single soybeans by transmission Raman spectroscopy.

PubMed

Schulmerich, Matthew V; Walsh, Michael J; Gelber, Matthew K; Kong, Rong; Kole, Matthew R; Harrison, Sandra K; McKinney, John; Thompson, Dennis; Kull, Linda S; Bhargava, Rohit

2012-08-22

The soybean industry requires rapid, accurate, and precise technologies for the analyses of seed/grain constituents. While the current gold standard for nondestructive quantification of economically and nutritionally important soybean components is near-infrared spectroscopy (NIRS), emerging technology may provide viable alternatives and lead to next generation instrumentation for grain compositional analysis. In principle, Raman spectroscopy provides the necessary chemical information to generate models for predicting the concentration of soybean constituents. In this communication, we explore the use of transmission Raman spectroscopy (TRS) for nondestructive soybean measurements. We show that TRS uses the light scattering properties of soybeans to effectively homogenize the heterogeneous bulk of a soybean for representative sampling. Working with over 1000 individual intact soybean seeds, we developed a simple partial least-squares model for predicting oil and protein content nondestructively. We find TRS to have a root-mean-standard error of prediction (RMSEP) of 0.89% for oil measurements and 0.92% for protein measurements. In both calibration and validation sets, the predicative capabilities of the model were similar to the error in the reference methods.

Dissolvable tattoo sensors: from science fiction to a viable technology

NASA Astrophysics Data System (ADS)

Cheng, Huanyu; Yi, Ning

2017-01-01

Early surrealistic painting and science fiction movies have envisioned dissolvable tattoo electronic devices. In this paper, we will review the recent advances that transform that vision into a viable technology, with extended capabilities even beyond the early vision. Specifically, we focus on the discussion of a stretchable design for tattoo sensors and degradable materials for dissolvable sensors, in the form of inorganic devices with a performance comparable to modern electronics. Integration of these two technologies as well as the future developments of bio-integrated devices is also discussed. Many of the appealing ideas behind developments of these devices are drawn from nature and especially biological systems. Thus, bio-inspiration is believed to continue playing a key role in future devices for bio-integration and beyond.

Non-intrusive speed sensor. [space shuttle main engine turbopumps

NASA Technical Reports Server (NTRS)

Maram, J.; Wyett, L.

1984-01-01

A computerized literature search was performed to identify candidate technologies for remote, non-intrusive speed sensing applications in Space Shuttle Main Engine (SSME) turbopumps. The three most promising technologies were subjected to experimental evaluation to quantify their performance characteristics under the harsh environmental requirements within the turbopumps. Although the infrared and microwave approaches demonstrated excellent cavitation immunity in laboratory tests, the variable-source magnetic speed sensor emerged as the most viable approach. Preliminary design of this speed sensor encountered no technical obstacles and resulted in viable and feasible speed nut, sensor housing, and sensor coil designs.

Cognitive Theory within the Framework of an Information Processing Model and Learning Hierarchy: Viable Alternative to the Bloom-Mager System.

ERIC Educational Resources Information Center

Stahl, Robert J.

This review of the current status of the human information processing model presents the Stahl Perceptual Information Processing and Operations Model (SPInPrOM) as a model of how thinking, memory, and the processing of information take place within the individual learner. A related system, the Domain of Cognition, is presented as an alternative to…

Self-interested agents create, maintain, and modify group-functional culture.

PubMed

Singh, Manvir; Glowacki, Luke; Wrangham, Richard W

2016-01-01

We agree that institutions and rules are crucial for explaining human sociality, but we question the claim of there not being "alternatives to CGS [that] can easily account for the institutionalized cooperation that characterizes human societies" (target article, sect. 7). Hypothesizing that self-interested individuals coercively and collaboratively create rules, we propose that agent-based hypotheses offer viable alternatives to cultural group selection (CGS).

The Experimental Study of the Performance of Nano-Thin Polyelectrolyte Shell for Dental Pulp Stem Cells Immobilization.

PubMed

Grzeczkowicz, A; Granicka, L H; Maciejewska, I; Strawski, M; Szklarczyk, M; Borkowska, M

2015-12-01

Carious is the most frequent disease of mineralized dental tissues which might result in dental pulp inflammation and mortality. In such cases an endodontic treatment is the only option to prolong tooth functioning in the oral cavity; however, in the cases of severe pulpitis, especially when complicated with periodontal tissue inflammation, the endodontic treatment might not be enough to protect against tooth loss. Thus, keeping the dental pulp viable and/or possibility of the reconstruction of a viable dental pulp complex, appears to become a critical factor for carious and/or pulp inflammation treatment. The nowadays technologies, which allow handling dental pulp stem cells (DPSC), seem to bring us closer to the usage of dental stem cells for tooth tissues reconstruction. Thus, DPSC immobilized within nano-thin polymeric shells, allowing for a diffusion of produced factors and separation from bacteria, may be considered as a cover system supporting technology of dental pulp reconstruction. The DPSC were immobilized using a layer-by-layer technique within nano-thin polymeric shells constructed and modified by nanostructure involvement to ensure the layers stability and integrity as well as separation from bacterial cells. The cytotoxity of the material used for membrane production was assessed on the model of adherent cells. The performance of DPSC nano-coating was assessed in vitro. Membrane coatings showed no cytotoxicity on the immobilized cells. The presence of coating shell was confirmed with flow cytometry, atomic force microscopy and visualized with fluorescent microscopy. The transfer of immobilized DPSC within the membrane system ensuring cells integrity, viability and protection from bacteria should be considered as an alternative method for dental tissues transportation and regeneration.

Application placement technologies for vegetation management on North Carolina roadsides : final report.

DOT National Transportation Integrated Search

2007-05-30

Research experiments were designed and initiated to determine if application placement technologies offer : a viable solution for vegetation management along North Carolina Roadsides. Select equipment was evaluated for : broomsedge (Andropogon virgin...

CONTECH(R) A-2000 polyvinyl chloride (PVC) plastic pipe.

DOT National Transportation Integrated Search

2015-03-01

Determine the effectiveness and long-term durability of the Contech A-2000 PVC pipe : in an irrigation application. This type of pipe may prove to be a viable alternative to : reinforced concrete pipe (RCP).

Current state of OLED technology relative to military avionics requirements

NASA Astrophysics Data System (ADS)

Tchon, Joseph L.; Barnidge, Tracy J.; Hufnagel, Bruce D.; Bahadur, Birendra

2014-06-01

The paper will review optical and environmental performance thresholds required for OLED technology to be used on various military platforms. Life study results will be summarized to highlight trends while identifying remaining performance gaps to make this technology viable for future military avionics platforms.

Environmental analysis of Lower Pueblo/Lower Los Alamos Canyon, Los Alamos, New Mexico

DOE Office of Scientific and Technical Information (OSTI.GOV)

Ferenbaugh, R.W.; Buhl, T.E.; Stoker, A.K.

1994-12-01

The radiological survey of the former radioactive waste treatment plant site (TA-45), Acid Canyon, Pueblo Canyon, and Los Alamos Canyon found residual contamination at the site itself and in the channel and banks of Acid, Pueblo, and lower Los Alamos Canyons all the way to the Rio Grande. The largest reservoir of residual radioactivity is in lower Pueblo Canyon, which is on DOE property. However, residual radioactivity does not exceed proposed cleanup criteria in either lower Pueblo or lower Los Alamos Canyons. The three alternatives proposed are (1) to take no action, (2) to construct a sediment trap in lowermore » Pueblo Canyon to prevent further transport of residual radioactivity onto San Ildefonso Indian Pueblo land, and (3) to clean the residual radioactivity from the canyon system. Alternative 2, to cleanup the canyon system, is rejected as a viable alternative. Thousands of truckloads of sediment would have to be removed and disposed of, and this effort is unwarranted by the low levels of contamination present. Residual radioactivity levels, under either present conditions or projected future conditions, will not result in significant radiation doses to persons exposed. Modeling efforts show that future transport activity will not result in any residual radioactivity concentrations higher than those already existing. Thus, although construction of a sediment trap in lower Pueblo Canyon is a viable alternative, this effort also is unwarranted, and the no-action alternative is the preferred alternative.« less

The Role of stocking in the reestablishment and augmentation of native fish in the Lower Colorado River mainstream (1998-2002)

USGS Publications Warehouse

Mueller, Gordon

2003-01-01

Recovery in the main stem will only be accomplished with a dramatic decrease and possibly a total removal of nonnative species. After ten years and over $6 million in expenditures to remove nonnative fish it appears this philosophy is neither technically nor politically viable. In the meantime, stocking is the only alternative available to insure these species don’t disappear. The only viable option appears the creation and maintenance of small, isolated refuge communities where these species have shown they can produce young.

An Exploration of Scenarios to Support Sustainable Land Management Using Integrated Environmental Socio-economic Models

NASA Astrophysics Data System (ADS)

Fleskens, L.; Nainggolan, D.; Stringer, L. C.

2014-11-01

Scenario analysis constitutes a valuable deployment method for scientific models to inform environmental decision-making, particularly for evaluating land degradation mitigation options, which are rarely based on formal analysis. In this paper we demonstrate such an assessment using the PESERA-DESMICE modeling framework with various scenarios for 13 global land degradation hotspots. Starting with an initial assessment representing land degradation and productivity under current conditions, options to combat instances of land degradation are explored by determining: (1) Which technologies are most biophysically appropriate and most financially viable in which locations; we term these the "technology scenarios"; (2) how policy instruments such as subsidies influence upfront investment requirements and financial viability and how they lead to reduced levels of land degradation; we term these the "policy scenarios"; and (3) how technology adoption affects development issues such as food production and livelihoods; we term these the "global scenarios". Technology scenarios help choose the best technology for a given area in biophysical and financial terms, thereby outlining where policy support may be needed to promote adoption; policy scenarios assess whether a policy alternative leads to a greater extent of technology adoption; while global scenarios demonstrate how implementing technologies may serve wider sustainable development goals. Scenarios are applied to assess spatial variation within study sites as well as to compare across different sites. Our results show significant scope to combat land degradation and raise agricultural productivity at moderate cost. We conclude that scenario assessment can provide informative input to multi-level land management decision-making processes.

An exploration of scenarios to support sustainable land management using integrated environmental socio-economic models.

PubMed

Fleskens, L; Nainggolan, D; Stringer, L C

2014-11-01

Scenario analysis constitutes a valuable deployment method for scientific models to inform environmental decision-making, particularly for evaluating land degradation mitigation options, which are rarely based on formal analysis. In this paper we demonstrate such an assessment using the PESERA-DESMICE modeling framework with various scenarios for 13 global land degradation hotspots. Starting with an initial assessment representing land degradation and productivity under current conditions, options to combat instances of land degradation are explored by determining: (1) Which technologies are most biophysically appropriate and most financially viable in which locations; we term these the "technology scenarios"; (2) how policy instruments such as subsidies influence upfront investment requirements and financial viability and how they lead to reduced levels of land degradation; we term these the "policy scenarios"; and (3) how technology adoption affects development issues such as food production and livelihoods; we term these the "global scenarios". Technology scenarios help choose the best technology for a given area in biophysical and financial terms, thereby outlining where policy support may be needed to promote adoption; policy scenarios assess whether a policy alternative leads to a greater extent of technology adoption; while global scenarios demonstrate how implementing technologies may serve wider sustainable development goals. Scenarios are applied to assess spatial variation within study sites as well as to compare across different sites. Our results show significant scope to combat land degradation and raise agricultural productivity at moderate cost. We conclude that scenario assessment can provide informative input to multi-level land management decision-making processes.

Ex situ treatment of N-nitrosodimethylamine (NDMA) in groundwater using a fluidized bed reactor.

PubMed

Webster, Todd S; Condee, Charles; Hatzinger, Paul B

2013-02-01

N-nitrosodimethylamine (NDMA) is a suspected human carcinogen that has traditionally been treated in water using ultraviolet irradiation (UV). The objective of this research was to examine the application of a laboratory-scale fluidized bed reactor (FBR) as an alternative technology for treating NDMA to part-per-trillion (ng/L) concentrations in groundwater. Previous studies have shown that the bacterium Rhodococcus ruber ENV425 is capable of cometabolizing NDMA during growth on propane as a primary substrate in batch culture (Fournier et al., 2009) and in a bench-scale membrane bioreactor (Hatzinger et al., 2011) to low ng/L concentrations. R. ruber ENV425 was inoculated into the FBR during this study. With a hydraulic residence time (HRT) of 20 min, the FBR was found to be an effective means to treat 10-20 μg/L of NDMA to effluent concentrations less than 100 ng/L. When the HRT was increased to 30 min and oxygen and propane addition rates were optimized, the FBR system demonstrated treatment of the NDMA to effluent concentrations of less than 10 ng/L. Short-term shutdowns and the presence of trichloroethene (TCE) at 6 μg/L as a co-contaminant had minimal effect on the treatment of NDMA in the FBR. The data suggest that the FBR technology can be a viable alternative to UV for removing NDMA from groundwater. Copyright © 2012 Elsevier Ltd. All rights reserved.

Organic materials for printed electronics

NASA Astrophysics Data System (ADS)

Berggren, M.; Nilsson, D.; Robinson, N. D.

2007-01-01

Organic materials can offer a low-cost alternative for printed electronics and flexible displays. However, research in these systems must exploit the differences - via molecular-level control of functionality - compared with inorganic electronics if they are to become commercially viable.

Morristown Alternative Transportation Study Phase II.

DOT National Transportation Integrated Search

2005-10-14

This report summarizes the Phase II planning effort conducted by the park and the US Department of Transportation's Volpe Center (the Volpe Center) to articulate a viable park-community pilot transit service for Morristown National Historical Park. M...

Research notes : faster load rating for steel truss bridges.

DOT National Transportation Integrated Search

2009-03-01

The Oregon Department of Transportation (ODOT) Bridge Engineering Section recently completed a project with Oregon State University to develop a viable, more cost-effective alternative to the manually collected field measurement procedure. The new me...

Incorporation of capsaicin in silicone coatings for enhanced antifouling performance

NASA Astrophysics Data System (ADS)

Reddy Jaggari, Karunakar; Zhang Newby, Bi-Min

2002-03-01

Successful use of capsaicin as insect and animal repellant propelled us to use it as a possible antifouling agent. Its non-toxic, non-biocidal, non-leaching properties make it a viable alternative to organotin compounds. In order to optimize the anti-fouling performance of the coating, silicone, the most effective foul-release marine coating, was chosen as the carrier. We have incorporated capsaicin into silicone coating, by both bulk entrapment and surface immobilization. Contact angle measurements on capsaicin-incorporated silicone exhibited an increase in wettability, owing to the presence of capsaicin. FTIR study further confirmed the incorporation of capsaicin in silicone. Bacterial attachment studies were conducted using lake Erie water. While bacteria liberally inhabited the control coating, their presence on the capsaicin-incorporated coating was found to be minimal. These preliminary studies indicate that capsaicin incorporated silicone could be a viable environment friendly alternative to currently used antifouling coatings.

Laboratory Evaluation of Drop-in Solvent Alternatives to n-Propyl Bromide for Vapor Degreasing

NASA Technical Reports Server (NTRS)

Mitchell, Mark A.; Lowrey, Nikki M.

2012-01-01

Based on this limited laboratory study, solvent blends of trans-1,2 dichloroethylene with HFEs, HFCs, or PFCs appear to be viable alternatives to n-propyl bromide for vapor degreasing. The lower boiling points of these blends may lead to greater solvent loss during use. Additional factors must be considered when selecting a solvent substitute, including stability over time, VOC, GWP, toxicity, and business considerations.

New technologies in cervical cancer precursor detection.

PubMed

Soler, M E; Blumenthal, P D

2000-09-01

The current literature reflects three routes toward improving cervical cancer screening. The first is to improve the test qualities of cytology-based screening. The use of liquid-based cytology and computerized analysis of Papanicolaou tests are examples of attempts at this approach. Secondly, through various combinations of parallel or sequential tests, either the sensitivity or the specificity of a given test could be improved depending on the tests chosen and the order in which they were performed (eg, Papanicolaou test followed by human papillomavirus [HPV] or vice versa). Several excellent studies have been published this year on the use of HPV DNA testing as a primary screening modality and as an adjunct to the triage of mildly abnormal cytologic findings. The recent literature also reflects increasing interest in visual inspection of the cervix and self-collected samples for HPV testing as an equally effective and viable alternative to cytology in low-resource settings. A third possibility is to make use of advances in digital and spectroscopic techniques. In these cost-conscious times, a significant number of articles address the cost-effectiveness of these technologies and the real value of cervical cancer screening. This article reviews the current literature concerning both the advent of new cervical cancer screening technologies and the rediscovery of old ones.

The rapid reproducers paradox: population control and individual procreative rights.

PubMed

Wissenburg, M

1998-01-01

This article argues that population policies need to be evaluated from macro and micro perspectives and to consider individual rights. Ecological arguments that are stringent conditions of liberal democracy are assessed against a moral standard. The moral standard is applied to a series of reasons for limiting procreative rights in the cause of sustainability. The focus is directly on legally enforced antinatalist measures and not on indirect policies with incentives and disincentives. The explicit assumption is that population policy violates the fairness to individuals for societal gain and that population policies are incompatible with stringent conditions of liberal democracy. The author identifies the individual-societal tradeoff as the "rapid reproducers paradox." The perfect sustainable population level is either not possible or is a repugnant alternative. 12 ecological arguments are presented, and none are found compatible with notions of a liberal democracy. Three alternative antinatalist options are the acceptance of less rigid and still coercive policies, amendments to the conception of liberal democracy, or loss of hope and choice of noncoercive solutions to sustainability, none of which is found viable. If voluntary abstinence and distributive solutions fail, then frugal demand options and technological supply options both will be necessary.

Coloristic and antimicrobial behaviour of polymeric substrates using bioactive substances

NASA Astrophysics Data System (ADS)

Coman, D.; Vrînceanu, N.; Oancea, S.; Rîmbu, C.

2016-08-01

A major concern in reducing microbial contamination of healthcare and hygiene products motivated us to seek viable alternatives in order to create such barriers. The antimicrobial and anti-oxidant effects of natural extracts are well-known, their application onto polymeric supports is still challenging in terms of investigation. To our knowledge, the method of natural dyeing of different polymeric substrates using bioactive substances derived from black currant and green walnut shells, in conjunction with biomordants, and their long term effects have not been very consistently reported. The main objective of the study is based on the comparative study of different polymeric fibrous substrates dyed by means of laboratory scaled classic methodology with extracts from black currant fruits and green walnut shells, with the assistance of conventional and biomordants (copper sulphate, citric and tannic acids). The assistance of biomordant in the dyeing process seems to conduct to improved synergetic colouring and antibacterial performances. The main results demonstrated that the extract of green walnut shells reinforced by the biomordants solutions expressed the best antimicrobial behaviour. The present research is a milestone in the identification of potential technological alternatives applied in dyeing of synthetic and natural textile supports, quantified and controlled by antimicrobial response correlated with colorimetric features.

Comparative Analyses of Data Independent Acquisition Mass Spectrometric Approaches: DIA, WiSIM‐DIA, and Untargeted DIA

PubMed Central

Ho, Jenny T. C.; Smit, August B.; Li, Ka Wan

2018-01-01

Abstract Data‐independent acquisition (DIA) is an emerging technology for quantitative proteomics. Current DIA focusses on the identification and quantitation of fragment ions that are generated from multiple peptides contained in the same selection window of several to tens of m/z. An alternative approach is WiSIM‐DIA, which combines conventional DIA with wide‐SIM (wide selected‐ion monitoring) windows to partition the precursor m/z space to produce high‐quality precursor ion chromatograms. However, WiSIM‐DIA has been underexplored; it remains unclear if it is a viable alternative to DIA. We demonstrate that WiSIM‐DIA quantified more than 24 000 unique peptides over five orders of magnitude in a single 2 h analysis of a neuronal synapse‐enriched fraction, compared to 31 000 in DIA. There is a strong correlation between abundance values of peptides quantified in both the DIA and WiSIM‐DIA datasets. Interestingly, the S/N ratio of these peptides is not correlated. We further show that peptide identification directly from DIA spectra identified >2000 proteins, which included unique peptides not found in spectral libraries generated by DDA. PMID:29134766

Kinetically reduced local Navier-Stokes equations: an alternative approach to hydrodynamics.

PubMed

Karlin, Iliya V; Tomboulides, Ananias G; Frouzakis, Christos E; Ansumali, Santosh

2006-09-01

An alternative approach, the kinetically reduced local Navier-Stokes (KRLNS) equations for the grand potential and the momentum, is proposed for the simulation of low Mach number flows. The Taylor-Green vortex flow is considered in the KRLNS framework, and compared to the results of the direct numerical simulation of the incompressible Navier-Stokes equations. The excellent agreement between the KRLNS equations and the incompressible nonlocal Navier-Stokes equations for this nontrivial time-dependent flow indicates that the former is a viable alternative for computational fluid dynamics at low Mach numbers.

Cerebral Ketone Metabolism During Development and Injury

PubMed Central

Prins, Mayumi L.

2011-01-01

Cerebral metabolism of ketones is a normal part of the process of brain development. While the mature brain relies on glucose as a primary fuel source, metabolism of ketone bodies remains an alternative energy source under conditions of starvation. The neuroprotective properties of brain ketone metabolism make this alternative substrate a viable therapeutic option for various pathologies. Since the ability to revert to utilizing ketones as an alternative substrate is greatest in the younger post-weaned brain, this particular therapeutic approach remains an untapped resource particularly for pediatric pathological conditions. PMID:22104087

Participant Observation: A Promising Research Approach for Educational Technology

ERIC Educational Resources Information Center

Dodge, Martin; Bogdan, Robert

1974-01-01

Symbolic interaction is a useful perspective, a viable theoretical approach to getting at answers to many important questions related to educational technology. Participant observation is a useful methodology for rooting answers out of the research setting. (Author)

KNOW ESSENTIALS: a tool for informed decisions in the absence of formal HTA systems.

PubMed

Mathew, Joseph L

2011-04-01

Most developing countries and resource-limited settings lack robust health technology assessment (HTA) systems. Because the development of locally relevant HTA is not immediately viable, and the extrapolation of external HTA is inappropriate, a new model for evaluating health technologies is required. The aim of this study was to describe the development and application of KNOW ESSENTIALS, a tool facilitating evidence-based decisions on health technologies by stakeholders in settings lacking formal HTA systems. Current HTA methodology was examined through literature search. Additional issues relevant to resource-limited settings, but not adequately addressed in current methodology, were identified through further literature search, appraisal of contextually relevant issues, discussion with healthcare professionals familiar with the local context, and personal experience. A set of thirteen elements important for evidence-based decisions was identified, selected and combined into a tool with the mnemonic KNOW ESSENTIALS. Detailed definitions for each element, coding for the elements, and a system to evaluate a given health technology using the tool were developed. Developing countries and resource-limited settings face several challenges to informed decision making. Models that are relevant and applicable in high-income countries are unlikely in such settings. KNOW ESSENTIALS is an alternative that facilitates evidence-based decision making by stakeholders without formal expertise in HTA. The tool could be particularly useful, as an interim measure, in healthcare systems that are developing HTA capacity. It could also be useful anywhere when rapid evidence-based decisions on health technologies are required.

Cartilage-Repair Innovation at a Standstill: Methodologic and Regulatory Pathways to Breaking Free.

PubMed

Lyman, Stephen; Nakamura, Norimasa; Cole, Brian J; Erggelet, Christoph; Gomoll, Andreas H; Farr, Jack

2016-08-03

Articular cartilage defects strongly predispose patients to developing early joint degeneration and osteoarthritis, but for more than 15 years, no new cartilage-repair technologies that we know of have been approved by the U.S. Food and Drug Administration. Many studies examining novel approaches to cartilage repair, including cell, tissue, or matrix-based techniques, have shown great promise, but completing randomized controlled trials (RCTs) to establish safety and efficacy has been challenging, providing a major barrier to bringing these innovations into clinical use. In this article, we review reasons that surgical innovations are not well-suited for testing through RCTs. We also discuss how analytical methods for reducing bias, such as propensity scoring, make prospective observational studies a potentially viable alternative for testing the safety and efficacy of cartilage-repair and other novel therapies, offering the real possibility of therapeutic innovation. Copyright © 2016 by The Journal of Bone and Joint Surgery, Incorporated.

Producer gas production of Indonesian biomass in fixed-bed downdraft gasifier as an alternative fuels for internal combustion engines

NASA Astrophysics Data System (ADS)

Simanjuntak, J. P.; Lisyanto; Daryanto, E.; Tambunan, B. H.

2018-03-01

downdraft biomass gasification reactors, coupled with reciprocating internal combustion engines (ICE) are a viable technology for small scale heat and power generation. The direct use of producer gas as fuel subtitution in an ICE could be of great interest since Indonesia has significant land area in different forest types that could be used to produce bioenergy and convert forest materials to bioenergy for use in energy production and the versatility of this engine. This paper will look into the aspect of biomass energie as a contributor to energy mix in Indonesia. This work also contains information gathered from numerous previews study on the downdraft gasifier based on experimental or simulation study on the ability of producer gas as fuels for internal combustion engines aplication. All data will be used to complement the preliminary work on biomass gasification using downdraft to produce producer gas and its application to engines.

Increase in fault ride through capability of direct drive permanent magnet based wind farm using VSC-HVDC

NASA Astrophysics Data System (ADS)

Maleki, Hesamaldin; Ramachandaramurthy, V. K.; Lak, Moein

2013-06-01

Burning of fossil fuels and green house gasses causes global warming. This has led to governments to explore the use of green energies instead of fossil fuels. The availability of wind has made wind technology a viable alternative for generating electrical power. Hence, many parts of the world, especially Europe are experiencing a growth in wind farms. However, by increasing the number of wind farms connected to the grid, power quality and voltage stability of grid becomes a matter of concern. In this paper, VSC-HVDC control strategy which enables the wind farm to ride-through faults and regulate voltage for fault types is proposed. The results show that the wind turbine output voltage fulfills the E.ON grid code requirements, when subjected to three phase to ground fault. Hence, continues operation of the wind farm is achieved.

Current and New Insights in the Sustainable and Green Recovery of Nutritionally Valuable Compounds from Stevia rebaudiana Bertoni.

PubMed

Koubaa, Mohamed; Roselló-Soto, Elena; Šic Žlabur, Jana; Režek Jambrak, Anet; Brnčić, Mladen; Grimi, Nabil; Boussetta, Nadia; Barba, Francisco J

2015-08-12

The South American plant Stevia rebaudiana Bertoni is a great source of noncaloric sweeteners (steviol glycosides), mainly concentrated in its leaves, but also has important antioxidant compounds (vitamin C, polyphenols, chlorophylls, and carotenoids) and other important macro- and micronutrients such as folic acid and all of the essential amino acids except tryptophan. Traditionally, conventional methods have been used to recover nutritionally valuable compounds from plant food matrices. However, nowadays, the need for obtaining greener, sustainable, and viable processes has led both food industries and food scientists to develop new processes in full correspondence with the green extraction concept. This review focuses on some of the most promising nonconventional and emerging technologies, which may constitute a potential alternative to conventional methods or even could be combined to obtain a synergistic effect, thus reducing extraction time as well as solvent consumption and avoiding the use of toxic solvents.

Arc spray process for the aircraft and stationary gas turbine industry

NASA Astrophysics Data System (ADS)

Sampson, E. R.; Zwetsloot, M. P.

1997-06-01

Technological advances in arc spray have produced a system that competes favorably with other thermal spray processes. In the past, arc spray was thought of as a process for very large parts that need thick buildups. However, an attachment device known as the arc jet system has been developed that focuses the pattern and accelerates the particles. This attachment device, coupled with the in-troduction of metal-cored wires that provide the same chemistries as plasma-sprayed powders, pro-vides application engineers with a viable economic alternative to existing spray methods. A comparative evaluation of a standard production plasma spray system was conducted with the arc spray process using the attachment device. This evaluation was conducted by an airline company on four major parts coated with nickel-aluminum. Results show that, for these applications, the arc spray process offers several benefits.

Clinical skill development for community pharmacists.

PubMed

Barnette, D J; Murphy, C M; Carter, B L

1996-09-01

The importance of establishing clinical pharmacy services in the community cannot be understated in light of current challenges to the traditional dispensing role as the primary service of the community pharmacist. Advancements in automated dispensing technology and declining prescription fee reimbursement are rapidly forcing pharmacists to seek alternative sources of revenue. Providing pharmaceutical care is a viable option to increase customer loyalty job satisfaction, and reimbursement. To support the development of clinical services, academic institutions are forming partnerships with individual community practitioners to overcome perceived educational and training barriers. The authors describe the design and development of two unique clinical skill development programs at the University of Illinois at Chicago. This paper also outlines the patient focused services that the participants have established upon completing the training. These programs successfully enhanced participants' therapeutic knowledge base and facilitated development of the clinical skills necessary for direct patient care.

Chemical and physical aspects of refining coal liquids

NASA Astrophysics Data System (ADS)

Shah, Y. T.; Stiegel, G. J.; Krishnamurthy, S.

1981-02-01

Increasing costs and declining reserves of petroleum are forcing oil importing countries to develop alternate energy sources. The direct liquefaction of coal is currently being investigated as a viable means of producing substitute liquid fuels. The coal liquids derived from such processes are typically high in nitrogen, oxygen and sulfur besides having a high aromatic and metals content. It is therefore envisaged that modifications to existing petroleum refining technology will be necessary in order to economically upgrade coal liquids. In this review, compositional data for various coal liquids are presented and compared with those for petroleum fuels. Studies reported on the stability of coal liquids are discussed. The feasibility of processing blends of coal liquids with petroleum feedstocks in existing refineries is evaluated. The chemistry of hydroprocessing is discussed through kinetic and mechanistic studies using compounds which are commonly detected in coal liquids. The pros and cons of using conventional petroleum refining catalysts for upgrading coal liquids are discussed.

Evaluating the Paper-to-Screen Translation of Participant-Aided Sociograms with High-Risk Participants

PubMed Central

Hogan, Bernie; Melville, Joshua R.; Philips, Gregory Lee; Janulis, Patrick; Contractor, Noshir; Mustanski, Brian S.; Birkett, Michelle

2016-01-01

While much social network data exists online, key network metrics for high-risk populations must still be captured through self-report. This practice has suffered from numerous limitations in workflow and response burden. However, advances in technology, network drawing libraries and databases are making interactive network drawing increasingly feasible. We describe the translation of an analog-based technique for capturing personal networks into a digital framework termed netCanvas that addresses many existing shortcomings such as: 1) complex data entry; 2) extensive interviewer intervention and field setup; 3) difficulties in data reuse; and 4) a lack of dynamic visualizations. We test this implementation within a health behavior study of a high-risk and difficult-to-reach population. We provide a within–subjects comparison between paper and touchscreens. We assert that touchscreen-based social network capture is now a viable alternative for highly sensitive data and social network data entry tasks. PMID:28018995

MEMS reliability: coming of age

NASA Astrophysics Data System (ADS)

Douglass, Michael R.

2008-02-01

In today's high-volume semiconductor world, one could easily take reliability for granted. As the MOEMS/MEMS industry continues to establish itself as a viable alternative to conventional manufacturing in the macro world, reliability can be of high concern. Currently, there are several emerging market opportunities in which MOEMS/MEMS is gaining a foothold. Markets such as mobile media, consumer electronics, biomedical devices, and homeland security are all showing great interest in microfabricated products. At the same time, these markets are among the most demanding when it comes to reliability assurance. To be successful, each company developing a MOEMS/MEMS device must consider reliability on an equal footing with cost, performance and manufacturability. What can this maturing industry learn from the successful development of DLP technology, air bag accelerometers and inkjet printheads? This paper discusses some basic reliability principles which any MOEMS/MEMS device development must use. Examples from the commercially successful and highly reliable Digital Micromirror Device complement the discussion.

Web-based UMLS concept retrieval by automatic text scanning: a comparison of two methods.

PubMed

Brandt, C; Nadkarni, P

2001-01-01

The Web is increasingly the medium of choice for multi-user application program delivery. Yet selection of an appropriate programming environment for rapid prototyping, code portability, and maintainability remain issues. We summarize our experience on the conversion of a LISP Web application, Search/SR to a new, functionally identical application, Search/SR-ASP using a relational database and active server pages (ASP) technology. Our results indicate that provision of easy access to database engines and external objects is almost essential for a development environment to be considered viable for rapid and robust application delivery. While LISP itself is a robust language, its use in Web applications may be hard to justify given that current vendor implementations do not provide such functionality. Alternative, currently available scripting environments for Web development appear to have most of LISP's advantages and few of its disadvantages.

Electromagnetic launchers

NASA Astrophysics Data System (ADS)

Kolm, H.; Mongeau, P.; Williams, F.

1980-09-01

Recent advances in energy storage, switching and magnet technology make electromagnetic acceleration a viable alternative to chemical propulsion for certain tasks, and a means to perform other tasks not previously feasible. Applications include the acceleration of gram-size particles for hypervelocity research and the initiation of fusion by impact, a replacement for chemically propelled artillery, the transportation of cargo and personnel over inaccessible terrain, and the launching of space vehicles to supply massive space operations, and for the disposal of nuclear waste. The simplest launcher of interest is the railgun, in which a short-circuit slide or an arc is driven along two rails by direct current. The most sophisticated studied thus far is the mass driver, in which a superconducting shuttle bucket is accelerated by a line of pulse coils energized by capacitors at energy conversion efficiencies better than 90%. Other accelerators of interest include helical, brush-commutated motors, discrete coil arc commutated drivers, flux compression momentum transformers, and various hybrid electrochemical devices.

Evaluating the Paper-to-Screen Translation of Participant-Aided Sociograms with High-Risk Participants.

PubMed

Hogan, Bernie; Melville, Joshua R; Philips, Gregory Lee; Janulis, Patrick; Contractor, Noshir; Mustanski, Brian S; Birkett, Michelle

2016-05-01

While much social network data exists online, key network metrics for high-risk populations must still be captured through self-report. This practice has suffered from numerous limitations in workflow and response burden. However, advances in technology, network drawing libraries and databases are making interactive network drawing increasingly feasible. We describe the translation of an analog-based technique for capturing personal networks into a digital framework termed netCanvas that addresses many existing shortcomings such as: 1) complex data entry; 2) extensive interviewer intervention and field setup; 3) difficulties in data reuse; and 4) a lack of dynamic visualizations. We test this implementation within a health behavior study of a high-risk and difficult-to-reach population. We provide a within-subjects comparison between paper and touchscreens. We assert that touchscreen-based social network capture is now a viable alternative for highly sensitive data and social network data entry tasks.

REDUCING CHILDREN'S RISK FROM LEAD IN SOIL

EPA Science Inventory

Traditional methods for reducing risk from elevated levels of soil Pb involves removal, covering, or dilution by mixing with uncontaminated soil. Believing that in situ remediation techniques are viable alternatives, the EPA=s National Risk Management Research Laboratory (NRMRL) ...

Transportation and our aging population : Volpe Center helps shape future policy

DOT National Transportation Integrated Search

1997-01-01

The issue of providing our aging population with viable transportation alternatives to the private automobile is gaining increased attention from policy makers, particularly as members of the baby boom generation approach their retirement years. Howe...

Flexural behavior of R/C beams strengthened with CFRP sheets or fabric

DOT National Transportation Integrated Search

2002-08-01

The resistance to electro-chemical corrosion, high-strength to weight ratio, larger creep strain, fatigue resistance, nonmagnetic and non-metallic properties of carbon fiber reinforced polymer (CFRP) composites offer a viable alternative to bonding o...

View from... Photonics Meets Biology Summer School: The bio-mission of diode lasers

NASA Astrophysics Data System (ADS)

Won, Rachel

2015-12-01

Diode lasers represent a viable alternative to light sources used in many biomedical applications. Their ongoing development will further increase their importance, offering not only multiple wavelength ranges, but also higher power levels.

Dynamic light scattering: A fast and reliable method to analyze bacterial growth during the lag phase.

PubMed

Vargas, Susana; Millán-Chiu, Blanca E; Arvizu-Medrano, Sofía M; Loske, Achim M; Rodríguez, Rogelio

2017-06-01

A comparison between plate counting (PC) and dynamic light scattering (DLS) is reported. PC is the standard technique to determine bacterial population as a function of time; however, this method has drawbacks, such as the cumbersome preparation and handling of samples, as well as the long time required to obtain results. Alternative methods based on optical density are faster, but do not distinguish viable from non-viable cells. These inconveniences are overcome by using DLS. Two different bacteria strains were considered: Escherichia coli and Staphylococcus aureus. DLS was performed at two different illuminating conditions: continuous and intermittent. By the increment of particle size as a function of time, it was possible to observe cell division and the formation of aggregates containing very few bacteria. The scattered intensity profiles showed the lag phase and the transition to the exponential phase of growth, providing a quantity proportional to viable bacteria concentration. The results revealed a clear and linear correlation in both lag and exponential phase, between the Log 10 (colony-forming units/mL) from PC and the Log 10 of the scattered intensity I s from DLS. These correlations provide a good support to use DLS as an alternative technique to determine bacterial population. Copyright © 2017 Elsevier B.V. All rights reserved.

Use of ProteinChip technology for identifying biomarkers of parasitic diseases: the example of porcine cysticercosis (Taenia solium).

PubMed

Deckers, N; Dorny, P; Kanobana, K; Vercruysse, J; Gonzalez, A E; Ward, B; Ndao, M

2008-12-01

Taenia solium cysticercosis is a significant public health problem in endemic countries. The current serodiagnostic techniques are not able to differentiate between infections with viable cysts and infections with degenerated cysts. The objectives of this study were to identify specific novel biomarkers of these different disease stages in the serum of experimentally infected pigs using ProteinChip technology (Bio-Rad) and to validate these biomarkers by analyzing serum samples from naturally infected pigs. In the experimental sample set 30 discriminating biomarkers (p<0.05) were found, 13 specific for the viable phenotype, 9 specific for the degenerated phenotype and 8 specific for the infected phenotype (either viable or degenerated cysts). Only 3 of these biomarkers were also significant in the field samples; however, the peak profiles were not consistent among the two sample sets. Five biomarkers discovered in the sera from experimentally infected pigs were identified as clusterin, lecithin-cholesterol acyltransferase, vitronectin, haptoglobin and apolipoprotein A-I.

7 CFR 622.2 - Scope.

Code of Federal Regulations, 2012 CFR

2012-01-01

... AGRICULTURE WATER RESOURCES WATERSHED PROJECTS General § 622.2 Scope. (a) To assist sponsors in preparing and carrying out watershed plans, the Natural Resources Conservation Service (NRCS) shall conduct... extent of watershed problems and needs, and (2) Set forth viable alternative solutions consistent with...

7 CFR 622.2 - Scope.

Code of Federal Regulations, 2014 CFR

2014-01-01

... AGRICULTURE WATER RESOURCES WATERSHED PROJECTS General § 622.2 Scope. (a) To assist sponsors in preparing and carrying out watershed plans, the Natural Resources Conservation Service (NRCS) shall conduct... extent of watershed problems and needs, and (2) Set forth viable alternative solutions consistent with...

7 CFR 622.2 - Scope.

Code of Federal Regulations, 2011 CFR

2011-01-01

... AGRICULTURE WATER RESOURCES WATERSHED PROJECTS General § 622.2 Scope. (a) To assist sponsors in preparing and carrying out watershed plans, the Natural Resources Conservation Service (NRCS) shall conduct... extent of watershed problems and needs, and (2) Set forth viable alternative solutions consistent with...

7 CFR 622.2 - Scope.

Code of Federal Regulations, 2013 CFR

2013-01-01

... AGRICULTURE WATER RESOURCES WATERSHED PROJECTS General § 622.2 Scope. (a) To assist sponsors in preparing and carrying out watershed plans, the Natural Resources Conservation Service (NRCS) shall conduct... extent of watershed problems and needs, and (2) Set forth viable alternative solutions consistent with...

Microwave Pretreatment For Hydrolysis Of Cellulose

NASA Technical Reports Server (NTRS)

Cullingford, Hatice S.; George, Clifford E.; Lightsey, George R.

1993-01-01

Microwave pretreatment enhances enzymatic hydrolysis of cellulosic wastes into soluble saccharides used as feedstocks for foods, fuels, and other products. Low consumption of energy, high yield, and low risk of proposed hydrolysis process incorporating microwave pretreatment makes process viable alternative to composting.

Evaluation of the economic viability of narrow-gauge local rail systems

DOT National Transportation Integrated Search

2001-11-01

The purpose of this project is to investigate and determine whether narrow-gauge local rail is a viable transportation alternative in Florida. A number of proposals for transit greenways have been developed for various communities throughout Florida....

Training Programmes as Incubators.

ERIC Educational Resources Information Center

Erikson, Truls; Gjellan, Are

2003-01-01

A European technological university conducts quarterly incubator programs in which teams develop ideas into viable business plans. Analysis indicates that 57 of 102 ideas resulted in successful technology-based businesses and more than 400 students received hands-on experience in business start-up. (Contains 16 references.) (SK)

The Relevance and Future of Joint Logistics Over the Shore (JLOTS) Operations

DTIC Science & Technology

2013-04-01

whether commercial or emerging technology, to ensure viable capability as older platforms and capability reach their economical useful life. 15...ensure viable capability as older platforms and capability reach their economical useful life. ii TABLE OF CONTENTS CHAPTER 1: INTRODUCTION...and in the Falklands, of course, out of the question.19 Therefore, when the military junta of Argentina invaded the Falklands on 2 April 1982

40 CFR 35.2032 - Innovative and alternative technologies.

Code of Federal Regulations, 2014 CFR

2014-07-01

... 40 Protection of Environment 1 2014-07-01 2014-07-01 false Innovative and alternative technologies... Innovative and alternative technologies. (a) Funding for innovative and alternative technologies. Projects or... innovative or alternative technology shall receive increased grants under § 35.2152. (1) Only funds from the...

40 CFR 35.2032 - Innovative and alternative technologies.

Code of Federal Regulations, 2013 CFR

2013-07-01

... 40 Protection of Environment 1 2013-07-01 2013-07-01 false Innovative and alternative technologies... Innovative and alternative technologies. (a) Funding for innovative and alternative technologies. Projects or... innovative or alternative technology shall receive increased grants under § 35.2152. (1) Only funds from the...

40 CFR 35.2032 - Innovative and alternative technologies.

Code of Federal Regulations, 2012 CFR

2012-07-01

... 40 Protection of Environment 1 2012-07-01 2012-07-01 false Innovative and alternative technologies... Innovative and alternative technologies. (a) Funding for innovative and alternative technologies. Projects or... innovative or alternative technology shall receive increased grants under § 35.2152. (1) Only funds from the...

40 CFR 35.2032 - Innovative and alternative technologies.

Code of Federal Regulations, 2011 CFR

2011-07-01

... 40 Protection of Environment 1 2011-07-01 2011-07-01 false Innovative and alternative technologies... Innovative and alternative technologies. (a) Funding for innovative and alternative technologies. Projects or... innovative or alternative technology shall receive increased grants under § 35.2152. (1) Only funds from the...

40 CFR 35.2032 - Innovative and alternative technologies.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 40 Protection of Environment 1 2010-07-01 2010-07-01 false Innovative and alternative technologies... Innovative and alternative technologies. (a) Funding for innovative and alternative technologies. Projects or... innovative or alternative technology shall receive increased grants under § 35.2152. (1) Only funds from the...

Progress in supersonic cruise aircraft technology

NASA Technical Reports Server (NTRS)

Driver, C.

1978-01-01

The supersonic cruise aircraft research program identified significant improvements in the technology areas of propulsion, aerodynamics, structures, takeoff and landing procedures, and advanced configuration concepts. Application of these technology areas to a commercial aircraft is discussed. An advanced SST family of aircraft which may be environmentally acceptable, have flexible range-payload capability, and be economically viable is projected.

Invited review article: Large ring lasers for rotation sensing.

PubMed

Schreiber, Karl Ulrich; Wells, Jon-Paul R

2013-04-01

Over the last two decades a series of large ring laser gyroscopes have been built having an unparalleled scale factor. These upscaled devices have improved the sensitivity and stability for rotation rate measurements by six orders of magnitude when compared to previous commercial developments. This progress has made possible entirely new applications of ring laser gyroscopes in the fields of geophysics, geodesy, and seismology. Ring lasers are currently the only viable measurement technology, which is directly referenced to the instantaneous rotation axis of the Earth. The sensor technology is rapidly developing. This is evidenced by the first experimentally viable proposals to make terrestrial tests of general relativistic effects such as the frame dragging of the rotating Earth.

Mycoplasma testing of cell substrates and biologics: Review of alternative non-microbiological techniques.

PubMed

Volokhov, Dmitriy V; Graham, Laurie J; Brorson, Kurt A; Chizhikov, Vladimir E

2011-01-01

Mycoplasmas, particularly species of the genera Mycoplasma and Acholeplasma, are known to be occasional microbial contaminants of cell cultures that produce biologics. This presents a serious concern regarding the risk of mycoplasma contamination for research laboratories and commercial facilities developing and manufacturing cell-derived biological and biopharmaceutical products for therapeutic use. Potential undetected contamination of these products or process intermediates with mycoplasmas represents a potential safety risk for patients and a business risk for producers of biopharmaceuticals. To minimize these risks, monitoring for adventitious agents, such as viruses and mycoplasmas, is performed during the manufacture of biologics produced in cell culture substrates. The "gold standard" microbiological assay, currently recommended by the USP, EP, JP and the US FDA, for the mycoplasma testing of biologics, involves the culture of viable mycoplasmas in broth, agar plates and indicator cells. Although the procedure enables highly efficient mycoplasma detection in cell substrates and cell-derived products, the overall testing strategy is time consuming (a minimum of 28 days) and requires skilled interpretation of the results. The long time period required for these conventional assays does not permit their use for products with short shelf-lives or for timely 'go/no-go' decisions during routine in-process testing. PCR methodology has existed for decades, however PCR based and other alternative methods for mycoplasma detection have only recently been considered for application to biologics manufacture. The application of alternative nucleic acid-based, enzyme-based and/or recombinant cell-culture methods, particularly in combination with efficient sample preparation procedures, could provide advantages over conventional microbiological methods in terms of analytical throughput, simplicity, and turnaround time. However, a challenge to the application of alternative methods for detection of mycoplasmas remains whether these alternative methods can provide a limit of detection comparable or superior to those of the culture methods. An additional challenge is that nucleic acid amplification technique (NAT) methods do not allow for accurate discrimination between viable and non-viable mycoplasma contaminants, which might lead to false-positive results (e.g. from inactivated raw materials, etc.). Our review provides an overview of these alternative methods and discusses the pros and cons of their application for the testing of mycoplasmas in biologics and cell substrates. Published by Elsevier Ltd.

The point system for driver license administration : a viable alternative for Virginia?.

DOT National Transportation Integrated Search

1972-01-01

Traffic safety research was noted to have been unable to produce any empirical evidence that the introduction of a point system would affect, either negatively or positively, traffic accident statistics. In view of this absence of evidence, the simil...

Evaluation of Oregon's first hot mix asphalt recycling project : Woodburn, Oregon, 1977.

DOT National Transportation Integrated Search

1979-03-01

Pavement recycling has been suggested as a viable alternative to more conventional methods of pavement rehabilitation as a means of offsetting some of the problems resulting from spiraling energy costs and shortages of raw materials. This paper prese...

CEC Today, 2000-2001.

ERIC Educational Resources Information Center

Van Kuren, Lynda, Ed.

2001-01-01

Nine issues of the newsletter of the Council for Exceptional Children (CEC) include articles, news items, meeting announcements, news items of individual divisions, and professional advancement opportunities. Some major articles are: (1) "Home Schooling--A Viable Alternative for Students with Special Needs" (2) "High Stakes Testing…

Microsilica modified concrete for bridge deck overlays : construction report.

DOT National Transportation Integrated Search

1990-10-01

The study objective was to see if microsilica concrete (MC) is a viable alternative to the latex modified concrete (LMC) usually used on bridge deck overlays in Oregon. The study addresses MC overlays placed in 1989 on Portland cement concrete (PCC) ...

Wireless GPS fleet tracking system at the University of Albany.

DOT National Transportation Integrated Search

2014-07-01

This report provides an overview of the project undertaken at the University at Albany to make alternative transportation a more : viable option by implementing a GPS Tracking System on the University bus fleet and broadcasting the bus locations to c...

9 CFR 381.150 - Requirements for the production of fully cooked poultry products and partially cooked poultry...

Code of Federal Regulations, 2011 CFR

2011-01-01

... standards: (1) Lethality. A 7-log10 reduction of Salmonella or an alternative lethality that achieves an equivalent probability that no viable Salmonella organisms remain in the finished product, as well as the...

High Performance Thin Layer Chromatography.

ERIC Educational Resources Information Center

Costanzo, Samuel J.

1984-01-01

Clarifies where in the scheme of modern chromatography high performance thin layer chromatography (TLC) fits and why in some situations it is a viable alternative to gas and high performance liquid chromatography. New TLC plates, sample applications, plate development, and instrumental techniques are considered. (JN)

Erectable space platform for space sciences and applications

NASA Technical Reports Server (NTRS)

1979-01-01

The specific objectives of the study were to: (1) identify a viable conceptual design for the service module/platform; (2) assess the technology issues that must be faced in planning development; and (3) prepare an initial plan for bringing critical technologies up to acceptable levels.

Asnuntuck Community College's Machine Technology Certificate and Degree Programs.

ERIC Educational Resources Information Center

Irlen, Harvey S.; Gulluni, Frank D.

2002-01-01

States that although manufacturing remains a viable sector in Connecticut, it is experiencing skills shortages in the workforce. Describes the machine technology program's purpose, the development of the Asnuntuck Community College's (Connecticut) partnership with private sector manufacturers, the curriculum, the outcomes, and benefits of…

Model-based assist feature insertion for sub-40nm memory device

NASA Astrophysics Data System (ADS)

Suh, Sungsoo; Lee, Suk-joo; Choi, Seong-woon; Lee, Sung-Woo; Park, Chan-hoon

2009-04-01

Many issues need to be resolved for a production-worthy model based assist feature insertion flow for single and double exposure patterning process to extend low k1 process at 193 nm immersion technology. Model based assist feature insertion is not trivial to implement either for single and double exposure patterning compared to rule based methods. As shown in Fig. 1, pixel based mask inversion technology in itself has difficulties in mask writing and inspection although it presents as one of key technology to extend single exposure for contact layer. Thus far, inversion technology is tried as a cooptimization of target mask to simultaneously generate optimized main and sub-resolution assists features for a desired process window. Alternatively, its technology can also be used to optimize for a target feature after an assist feature types are inserted in order to simplify the mask complexity. Simplification of inversion mask is one of major issue with applying inversion technology to device development even if a smaller mask feature can be fabricated since the mask writing time is also a major factor. As shown in Figure 2, mask writing time may be a limiting factor in determining whether or not an inversion solution is viable. It can be reasoned that increased number of shot counts relates to increase in margin for inversion methodology. On the other hand, there is a limit on how complex a mask can be in order to be production worthy. There is also source and mask co-optimization which influences the final mask patterns and assist feature sizes and positions for a given target. In this study, we will discuss assist feature insertion methods for sub 40-nm technology.

Selection of Sustainable Technology for VOC Abatement in an Industry: An Integrated AHP-QFD Approach

NASA Astrophysics Data System (ADS)

Gupta, Alok Kumar; Modi, Bharat A.

2018-04-01

Volatile organic compounds (VOCs) are universally present in global atmospheric pollutants. These VOCs are responsible for photo chemical reaction in atmosphere leading to serious harmful effects on human health and environment. VOCs are produced from both natural and man-made sources and may have good commercial value if it can be utilized as alternate fuel. As per data from US EPA, 15% of total VOC emissions are generated from surface coating industry but VOC concentration and exhaust air volume varies to a great extent and is dependent on processes used by industry. Various technologies are available for abatement of VOCs. Physical, Chemical and Biological technologies are available to remove VOCs by either recovery or destruction with many advantages and limitations. With growing environmental awareness and considering the resource limitations of medium and small scale industries, requirement of a tool for selecting appropriate techno economically viable solution for removal of VOCs from industrial process exhaust is envisaged. The aim of the present study is to provide management a tool to determine the overall effect of implementation of VOC abatement technology on business performance and VOC emissions. The primary purpose of this work is to outline a methodology to rate various VOC abatement technologies with respect to the constraint of meeting current and foreseeable future regulatory requirements, operational flexibility and Over All Economics Parameters considering conservation of energy. In this paper an integrated approach has been proposed to select most appropriate abatement technology strategically. Analytical hierarchy process and Quality function deployment have been integrated for Techno-commercial evaluation. A case study on selection of VOC abatement technology for a leading aluminium foil surface coating, lamination and printing facility using this methodology is presented in this study.

Integrated NO{sub x} control at New England Power, Salem Harbor Station

DOE Office of Scientific and Technical Information (OSTI.GOV)

Frish, M.B.; Johnson, S.A.; Comer, J.P.

Selective non-catalytic reduction (SNCR) is a viable technology for reducing NO{sub x} emissions from coal-fired boilers, especially those older units where large capital expenditures for alternative technologies may not be justified. However, NO{sub x} reduction efficiency of the SNCR process is maximized when the proper amount of reagent is injected at the proper temperature and dispersed rapidly enough to avoid ammonia slip. Early NEP experience at Salem Harbor station indicated that NO{sub x} reductions of 60% were achievable with SNCR. However, less NO{sub x} reductions were tolerated to avoid NH{sub 3} slip and subsequent flyash contamination and visible stack plumemore » resulting from excess ammonia. Preliminary tests by PSI Environmental showed that ammonia slip could be monitored in real time using their patented SpectraScan{trademark}-NH{sub 3} instrument, and that furnace exit temperature could be continuously monitored and controlled using GasTemp{trademark} another PSI Environmental product. Based on this information, detailed tests were planned to show integrated control over the SNCR process. A goal of the project was to achieve lower NO{sub x} with less reagent! This paper describes the status of the project.« less

Physical and Economic Integration of Carbon Capture Methods with Sequestration Sinks

NASA Astrophysics Data System (ADS)

Murrell, G. R.; Thyne, G. D.

2007-12-01

Currently there are several different carbon capture technologies either available or in active development for coal- fired power plants. Each approach has different advantages, limitations and costs that must be integrated with the method of sequestration and the physiochemical properties of carbon dioxide to evaluate which approach is most cost effective. For large volume point sources such as coal-fired power stations, the only viable sequestration sinks are either oceanic or geological in nature. However, the carbon processes and systems under consideration produce carbon dioxide at a variety of pressure and temperature conditions that must be made compatible with the sinks. Integration of all these factors provides a basis for meaningful economic comparisons between the alternatives. The high degree of compatibility between carbon dioxide produced by integrated gasification combined cycle technology and geological sequestration conditions makes it apparent that this coupling currently holds the advantage. Using a basis that includes complete source-to-sink sequestration costs, the relative cost benefit of pre-combustion IGCC compared to other post-combustion methods is on the order of 30%. Additional economic benefits arising from enhanced oil recovery revenues and potential sequestration credits further improve this coupling.

Environmental Impacts of Future Urban Deployment of Electric Vehicles: Assessment Framework and Case Study of Copenhagen for 2016-2030.

PubMed

Bohnes, Florence A; Gregg, Jay S; Laurent, Alexis

2017-12-05

To move toward environmentally sustainable transport systems, electric vehicles (EVs) are increasingly seen as viable alternatives to internal combustion vehicles (ICVs). To ensure effectiveness of such deployment, holistic assessments of environmental impacts can help decision-makers determine optimized urban strategies in a long-term perspective. However, explicit guidance and conduct of such assessments are currently missing. Here, we therefore propose a framework using life cycle assessment that enables the quantification of environmental impacts of a transport system at full urban scale from a fleet-based, foresight perspective. The analysis of the passenger car fleet development in the city of Copenhagen for the years 2016-2030 is used as a proof-of-concept. We modeled and compared five powertrain technologies, and we assessed four fleet-based scenarios for the entire city. Our results showed relative environmental benefits from range-extended and fuel-cell EVs over ICVs and standard EVs. These results were found to be sensitive to local settings, like electricity grid mix, which could alter the relative environmental performances across EV technologies. The comprehensive framework developed here can be applied to other geographic areas and contexts to assess the environmental sustainability of transport systems.

Microalgae as sustainable renewable energy feedstock for biofuel production.

PubMed

Medipally, Srikanth Reddy; Yusoff, Fatimah Md; Banerjee, Sanjoy; Shariff, M

2015-01-01

The world energy crisis and increased greenhouse gas emissions have driven the search for alternative and environmentally friendly renewable energy sources. According to life cycle analysis, microalgae biofuel is identified as one of the major renewable energy sources for sustainable development, with potential to replace the fossil-based fuels. Microalgae biofuel was devoid of the major drawbacks associated with oil crops and lignocelluloses-based biofuels. Algae-based biofuels are technically and economically viable and cost competitive, require no additional lands, require minimal water use, and mitigate atmospheric CO2. However, commercial production of microalgae biodiesel is still not feasible due to the low biomass concentration and costly downstream processes. The viability of microalgae biodiesel production can be achieved by designing advanced photobioreactors, developing low cost technologies for biomass harvesting, drying, and oil extraction. Commercial production can also be accomplished by improving the genetic engineering strategies to control environmental stress conditions and by engineering metabolic pathways for high lipid production. In addition, new emerging technologies such as algal-bacterial interactions for enhancement of microalgae growth and lipid production are also explored. This review focuses mainly on the problems encountered in the commercial production of microalgae biofuels and the possible techniques to overcome these difficulties.

Phage and Yeast Display.

PubMed

Sheehan, Jared; Marasco, Wayne A

2015-02-01

Despite the availability of antimicrobial drugs, the continued development of microbial resistance--established through escape mutations and the emergence of resistant strains--limits their clinical utility. The discovery of novel, therapeutic, monoclonal antibodies (mAbs) offers viable clinical alternatives in the treatment and prophylaxis of infectious diseases. Human mAb-based therapies are typically nontoxic in patients and demonstrate high specificity for the intended microbial target. This specificity prevents negative impacts on the patient microbiome and avoids driving the resistance of nontarget species. The in vitro selection of human antibody fragment libraries displayed on phage or yeast surfaces represents a group of well-established technologies capable of generating human mAbs. The advantage of these forms of microbial display is the large repertoire of human antibody fragments present during a single selection campaign. Furthermore, the in vitro selection environments of microbial surface display allow for the rapid isolation of antibodies--and their encoding genes--against infectious pathogens and their toxins that are impractical within in vivo systems, such as murine hybridomas. This article focuses on the technologies of phage display and yeast display, as these strategies relate to the discovery of human mAbs for the treatment and vaccine development of infectious diseases.

Transportation Beyond 2000: Technologies Needed for Engineering Design

NASA Technical Reports Server (NTRS)

Huebner, Lawrence D. (Compiler); Asbury, Scott C. (Compiler); Lamar, John E. (Compiler); McKinley, Robert E., Jr. (Compiler); Scott, Robert C. (Compiler); Small, William J. (Compiler); Torres, Abel O. (Compiler)

1996-01-01

The purpose of the workshop was to acquaint the staff of the NASA Langley Research Center with the broad spectrum of transportation challenges and concepts foreseen within the next 20 years. The hope is that material presented at the workshop and contained in this document will stimulate innovative high-payoff research directed towards the efficiency of future transportation systems. The workshop included five sessions designed to stress the factors that will lead to a revolution in the way we will travel in the 21st century. The first session provides the historical background and a general perspective for future transportation, including emerging transportation alternatives such as working at a distance. Personal travel is the subject of Session Two. The third session looks at mass transportation, including advanced rail vehicles, advanced commuter aircraft, and advanced transport aircraft. The fourth session addresses some of the technologies required for the above revolutionary transportation systems to evolve. The workshop concluded with a wrap-up panel discussion, Session Five. The topics presented herein all have viable technical components and are at a stage in their development that, with sufficient engineering research, one or more of these could make a significant impact on transportation and our social structure.

MotifMark: Finding regulatory motifs in DNA sequences.

PubMed

Hassanzadeh, Hamid Reza; Kolhe, Pushkar; Isbell, Charles L; Wang, May D

2017-07-01

The interaction between proteins and DNA is a key driving force in a significant number of biological processes such as transcriptional regulation, repair, recombination, splicing, and DNA modification. The identification of DNA-binding sites and the specificity of target proteins in binding to these regions are two important steps in understanding the mechanisms of these biological activities. A number of high-throughput technologies have recently emerged that try to quantify the affinity between proteins and DNA motifs. Despite their success, these technologies have their own limitations and fall short in precise characterization of motifs, and as a result, require further downstream analysis to extract useful and interpretable information from a haystack of noisy and inaccurate data. Here we propose MotifMark, a new algorithm based on graph theory and machine learning, that can find binding sites on candidate probes and rank their specificity in regard to the underlying transcription factor. We developed a pipeline to analyze experimental data derived from compact universal protein binding microarrays and benchmarked it against two of the most accurate motif search methods. Our results indicate that MotifMark can be a viable alternative technique for prediction of motif from protein binding microarrays and possibly other related high-throughput techniques.

3D Printing of Scaffolds for Tissue Regeneration Applications.

PubMed

Do, Anh-Vu; Khorsand, Behnoush; Geary, Sean M; Salem, Aliasger K

2015-08-26

The current need for organ and tissue replacement, repair, and regeneration for patients is continually growing such that supply is not meeting demand primarily due to a paucity of donors as well as biocompatibility issues leading to immune rejection of the transplant. In order to overcome these drawbacks, scientists have investigated the use of scaffolds as an alternative to transplantation. These scaffolds are designed to mimic the extracellular matrix (ECM) by providing structural support as well as promoting attachment, proliferation, and differentiation with the ultimate goal of yielding functional tissues or organs. Initial attempts at developing scaffolds were problematic and subsequently inspired an interest in 3D printing as a mode for generating scaffolds. Utilizing three-dimensional printing (3DP) technologies, ECM-like scaffolds can be produced with a high degree of complexity, where fine details can be included at a micrometer level. In this Review, the criteria for printing viable and functional scaffolds, scaffolding materials, and 3DP technologies used to print scaffolds for tissue engineering are discussed. Creating biofunctional scaffolds could potentially help to meet the demand by patients for tissues and organs without having to wait or rely on donors for transplantation. © 2015 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Revisiting adoption of high transmission PSM: pros, cons and path forward

NASA Astrophysics Data System (ADS)

Ma, Z. Mark; McDonald, Steve; Progler, Chris

2009-12-01

High transmission attenuated phase shift masks (Hi-T PSM) have been successfully applied in volume manufacturing for certain memory devices. Moreover, numerous studies have shown the potential benefits of Hi-T PSM for specific lithography applications. In this paper, the potential for extending Hi-T PSM to logic devices, is revisited with an emphasis on understanding layout, transmission, and manufacturing of Hi-T PSM versus traditional 6% embedded attenuated phase shift mask (EAPSM). Simulations on various layouts show Hi-T PSM has advantage over EAPSM in low duty cycle line patterns and high duty cycle space patterns. The overall process window can be enhanced when Hi- T PSM is combined with optimized optical proximity correction (OPC), sub-resolution assist features (SRAF), and source illumination. Therefore, Hi-T PSM may be a viable and lower cost alternative to other complex resolution enhancement technology (RET) approaches. Aerial image measurement system (AIMS) results on test masks, based on an inverse lithography technology (ILT) generated layout, confirm the simulation results. New advancement in high transmission blanks also make low topography Hi-T PSM a reality, which can minimize scattering effects in high NA lithography.

Microalgae as Sustainable Renewable Energy Feedstock for Biofuel Production

PubMed Central

Yusoff, Fatimah Md.; Shariff, M.

2015-01-01

The world energy crisis and increased greenhouse gas emissions have driven the search for alternative and environmentally friendly renewable energy sources. According to life cycle analysis, microalgae biofuel is identified as one of the major renewable energy sources for sustainable development, with potential to replace the fossil-based fuels. Microalgae biofuel was devoid of the major drawbacks associated with oil crops and lignocelluloses-based biofuels. Algae-based biofuels are technically and economically viable and cost competitive, require no additional lands, require minimal water use, and mitigate atmospheric CO2. However, commercial production of microalgae biodiesel is still not feasible due to the low biomass concentration and costly downstream processes. The viability of microalgae biodiesel production can be achieved by designing advanced photobioreactors, developing low cost technologies for biomass harvesting, drying, and oil extraction. Commercial production can also be accomplished by improving the genetic engineering strategies to control environmental stress conditions and by engineering metabolic pathways for high lipid production. In addition, new emerging technologies such as algal-bacterial interactions for enhancement of microalgae growth and lipid production are also explored. This review focuses mainly on the problems encountered in the commercial production of microalgae biofuels and the possible techniques to overcome these difficulties. PMID:25874216

Transportation Beyond 2000: Technologies Needed for Engineering Design

NASA Technical Reports Server (NTRS)

Huebner, Lawrence D. (Compiler); Asbury, Scott C. (Compiler); Lamar, John E. (Compiler); McKinley, Robert E., Jr. (Compiler); Scott, Robert C. (Compiler); Small, William J. (Compiler); Torres, Abel O. (Compiler)

1996-01-01

The purpose of the workshop was to acquaint the staff of the NASA Langley Research Center with the broad spectrum of transportation challenges and concepts foreseen within the next 20 years. The hope is that the material presented at the workshop and contained in this document will stimulate innovative high-payoff research directed towards the efficiency of future transportation systems. The workshop included five sessions designed to stress the factors that will lead to a revolution in the way we will travel in the 21st century. The first session provides the historical background and a general perspective for future transportation, including emerging transportation alternatives such as working at a distance. Personal travel is the subject of Session Two. The third session looks at mass transportation, including advanced rail vehicles, advanced commuter aircraft, and advanced transport aircraft. The fourth session addresses some of the technologies required for the above revolutionary transportation systems to evolve. The workshop concluded with a wrap-up panel discussion, Session Five. The topics presented herein all have viable technical components and are at a stage in their development that, with sufficient engineering research, one or more of these could make a significant impact on transportation and our social structure.

Kinetic Resolution of Secondary Alcohols Using Amidine-Based Catalysts

PubMed Central

Li, Ximin; Jiang, Hui; Uffman, Eric W.; Guo, Lei; Zhang, Yuhua; Yang, Xing; Birman, Vladimir B.

2012-01-01

Kinetic resolution of racemic alcohols has been traditionally achieved via enzymatic enantioselective esterification and ester hydrolysis. However, there has long been considerable interest in devising nonenzymatic alternative methods for this transformation. Amidine-Based Catalysts (ABCs), a new class of enantioselective acyl transfer catalysts developed in our group, have demonstrated, inter alia, high efficacy in the kinetic resolution of benzylic, allylic and propargylic secondary alcohols and 2-substituted cycloalkanols, and thus provide a viable alternative to enzymes. PMID:22283696

An Analysis of AAFES and Its Relevance to the Future of the Army and Air Force

DTIC Science & Technology

2009-06-12

benefits of this organization and are there any viable alternatives? Background and Significance AAFES provides retail goods and services to a select...relative to cost, benefit , and alternative options. Assumptions This study is based on the assumptions that AAFES and the MWR programs of the Army...AAFES is a joint Army and Air Force non-appropriated fund instrumentality (NAFI) charged with operating retail and service activities for the benefit

CQI proiect Every other day nocturnal HHD - An alternative approach to reduce burden.

PubMed

2016-08-01

More frequent dialysis, typically performed five to six times per week at home, has been associated with a num- ber of clinical, cardiovascular, and health-related quality of life (HRQOL) benefits. Daily therapy often results in a burden for patients and care partners. A continuous qual- ity improvement (CQI) initiative was conducted to evaluate if an alternate day, longer duration therapy (3.5 treatments with six to 10 hour treatments per week) would provide a viable alternative for home hemodialysis (HHD). This initia- tive demonstrated that every other day (EOD) nocturnal HD is a feasible alternative option to daily HHD and should be considered to individualize home dialysis therapy.

Viability, diversity and composition of the bacterial community in a high Arctic permafrost soil from Spitsbergen, Northern Norway.

PubMed

Hansen, Aviaja A; Herbert, Rodney A; Mikkelsen, Karina; Jensen, Lars Liengård; Kristoffersen, Tommy; Tiedje, James M; Lomstein, Bente Aa; Finster, Kai W

2007-11-01

The viable and non-viable fractions of the bacterial community in a 2347-year-old permafrost soil from Spitsbergen were subjected to a comprehensive investigation using culture-independent and culture-dependent methods. LIVE/DEAD BacLight staining revealed that 26% of the total number of bacterial cells were viable. Quantitatively, aerobic microcolonies, aerobic colony-forming units and culturable anaerobic bacteria comprised a minor fraction of the total number of viable bacteria, which underlines the necessity for alternative cultivation approaches in bacterial cryobiology. Sulfate reduction was detected at temperatures between -2 degrees C and 29 degrees C while methanogenesis was not detected. Bacterial diversity was high with 162 operational taxonomic units observed from 800 16S rDNA clone sequences. The 158 pure cultures isolated from the permafrost soil affiliated with 29 different bacterial genera, the majority of which have not previously been isolated from permafrost habitats. Most of the strains isolated were affiliated to the genera Cellulomonas and Arthrobacter and several of the pure cultures were closely related to bacteria reported from other cryohabitats. Characterization of viable bacterial communities in permafrost soils is important as it will enable identification of functionally important groups together with the as yet undescribed adaptations that bacteria have evolved for surviving subzero temperatures for millennia.

Aspergillus fumigatus viability drives allergic responses to inhaled conidia.

PubMed

Nayak, Ajay P; Croston, Tara L; Lemons, Angela R; Goldsmith, W T; Marshall, Nikki B; Kashon, Michael L; Germolec, Dori R; Beezhold, Donald H; Green, Brett J

2018-04-13

Aspergillus fumigatus induced allergic airway disease has been shown to involve conidial germination in vivo but the immunological mechanisms remain uncharacterized. A subchronic murine exposure model was used to examine the immunological mediators that are regulated in response to either culturable or non-culturable A. fumigatus conidia. Female B6C3F1/N mice were repeatedly dosed via inhalation with 1 x 105 viable or heat inactivated conidia (HIC), twice a week for 13 weeks (26 exposures). Control mice inhaled HEPA-filtered air. The influence of A. fumigatus conidial germination on the pulmonary immunopathological outcomes was evaluated by flow cytometry analysis of cellular infiltration in the airways, assessment of lung mRNA expression, and quantitative proteomics and histopathology of whole lung tissue. Repeated inhalation of viable conidia, but not HIC, resulted in allergic inflammation marked by vascular remodeling, extensive eosinophilia, and accumulation of alternatively activated macrophages (AAMs) in the murine airways. More specifically, mice that inhaled viable conidia resulted in a mixed TH1 and TH2 (IL-13) cytokine response. Recruitment of eosinophils corresponded with increased Ccl11 transcripts. Furthermore, genes associated with M2 or alternatively activated macrophage polarization (e.g. Arg1, Chil3 and Retnla) were significantly upregulated in viable A. fumigatus exposed mice. In mice inhaling HIC, CD4+ T cells expressing IFN-γ (TH1) dominated the lymphocytic infiltration. Quantitative proteomics of the lung revealed metabolic reprogramming accompanied by mitochondrial dysfunction and endoplasmic reticulum stress stimulated by oxidative stress from repetitive microbial insult. Our studies demonstrate that A. fumigatus conidial viability in vivo is critical to the immunopathological presentation of chronic fungal allergic disease. Copyright © 2018. Published by Elsevier Inc.

Assessing Gas and Oil Resources in the Intermountain West. Review of Methods and Framework For a New Approach

DTIC Science & Technology

2002-01-01

Green River Basin ............................... 28 4.1. Economically Recoverable Oil and Gas in the United States (USGS...viable gas and oil resource. The next step will be to apply this methodology to estimate the viable resource in individual basins . RAND will begin this...effort by analyzing the Green River Basin . The analysis will specify the relationships among gas and oil deposits, technological options, economic

NASA Collaborative Approach Mitigates Environmentally-Driven Obsolescence

NASA Technical Reports Server (NTRS)

Greene, Brian; Leeney, Bob; Richards, Joni

2016-01-01

National Aeronautics and Space Administration (NASA) missions, like Department of Defense (DoD) organizations, require the rigorous testing and qualification of critical materials. Obsolescence supply risks created by environmental requirements can affect the cost, schedule and performance of NASA missions and the resilience of critical infrastructure. The NASA Technology Evaluation for Environmental Risk Mitigation (TEERM) Principal Center helps to identify obsolescence supply risks driven by environmental requirements and works proactively with NASA Centers and Programs, the DoD, the European Space Agency (ESA) and other agencies and partners to identify and evaluate environmentally friendly alternatives. TEERM tracks environmental regulations, identifies the potential loss of material availability and works with NASA programs and Centers to evaluate potential impacts through a risk assessment approach. TEERM collaborative projects identify, demonstrate and evaluate commercially viable alternative technologies and materials. A major focus during the Space Shuttle Program was the need to replace ozone depleting substances that were used in spray foam and cleaning applications. The potential obsolescence of coatings containing hexavalent chromium and the risks associated with lead free solder were also of concern for the Space Shuttle and present ongoing risks to new programs such as the Space Launch System. One current project teams NASA and ESA in the evaluation and testing of individual coatings and coating systems as replacements for hexavalent chromium coatings in aerospace applications. The proactive, collaborative approach used by TEERM helps reduce the cost burden on any one team partner, reduces duplication of effort, and enhances the technical quality and overall applicability of the testing and analysis.

Optoelectronic advancements in analog avionics networking systems

NASA Astrophysics Data System (ADS)

Wilgus, Joseph S.

1996-12-01

Over the past two decades, the types of networks used in both commercial and military systems to route information throughout a designated platform have essentially remained unchanged. Traditionally, digital networks have been used to route low data rate, low-bandwidth signals usually not exceeding 2 Ghz, amongst a variety of sensors, digital and signal processors and video displays. On the other hand, analog networks have been responsible for routing broad- banded radio-frequency signals, those ranging from 2 Ghz to well beyond 100 Ghz, between a specific antenna aperture and its designated receiver type. Current analog systems use one of either two approaches to transfer this signal information. The first approach uses microwave waveguides. This design is very efficient, albeit bulky, and has typically been used in ground-based systems. HOwever, it does not lend itself very well to airborne platforms where size and weight constraint are of primary concern. The second approach uses coaxial cable, which tends to exhibit excessive loss at higher frequencies and is much heavier than optical fiber. Like its counterpart the microwave waveguide, it too is not ideally suited for airborne platforms. However, up to now it has been the technology of choice for this particular application. This has led to other alternatives to be sought. With recent advancements being made in optoelectronics, optical fiber is becoming a viable alternative to the above mentioned approaches. It is the intent of this paper to identify airborne applications for photonic technology in analog networks and discuss the needed building blocks to implement this particular type of system.

Montana BioDiesel Initiative

DOE Office of Scientific and Technical Information (OSTI.GOV)

Peyton, Brent

This initiative funding helped put Montana State University (MSU) in a position to help lead in the development of biodiesel production strategies. Recent shortages in electrical power and rising gasoline prices have focused much attention on the development of alternative energy sources that will end our dependence on fossil fuels. In addition, as the concern for environmental impact of utilizing fossil fuels increases, effective strategies must be implemented to reduce emissions or the increased regulations imposed on fossil fuel production will cause economic barriers for their use to continue to increase. Biodiesel has been repeatedly promoted as a more environmentallymore » sound and renewable source of fuel and may prove to be a highly viable solution to provide, at the least, a proportion of our energy needs. Currently there are both practical and economic barriers to the implementation of alternative energy however the advent of these technologies is inevitable. Since many of the same strategies for the storage, transport, and utilization of biodiesel are common with that of fossil fuels, the practical barriers for biodiesel are comparatively minimal. Strategies were developed to harness the CO 2 as feedstock to support the growth of biodiesel producing algae. The initiative funding led to the successful funding of highly rated projects in competitive national grant programs in the National Science Foundation and the Department of Energy. This funding put MSU in a key position to develop technologies to utilize the CO 2 rich emissions produced in fossil fuel utilization and assembled world experts concerning the growth characteristics of photosynthetic microorganisms capable of producing biodiesel.« less

A forecast of broadcast satellite communications

NASA Technical Reports Server (NTRS)

Martino, J. P.; Lenz, R. C., Jr.

1977-01-01

This paper presents forecasts of likely changes in broadcast satellite technology, the technology of ground terminals, and the technology of terrestrial communications competitive with satellites. The impacts of these changes in technology are then assessed, using a cross-impact model of U.S. domestic telecommunications, to determine the consequences of various possible changes in communications satellite technology. These consequences are discussed in terms of various possible services, for households, businesses, and specialized customers, which might become economically viable as a result of improvements in satellite technology.

Instrumentation for optimizing an underground coal-gasification process

NASA Astrophysics Data System (ADS)

Seabaugh, W.; Zielinski, R. E.

1982-06-01

While the United States has a coal resource base of 6.4 trillion tons, only seven percent is presently recoverable by mining. The process of in-situ gasification can recover another twenty-eight percent of the vast resource, however, viable technology must be developed for effective in-situ recovery. The key to this technology is system that can optimize and control the process in real-time. An instrumentation system is described that optimizes the composition of the injection gas, controls the in-situ process and conditions the product gas for maximum utilization. The key elements of this system are Monsanto PRISM Systems, a real-time analytical system, and a real-time data acquisition and control system. This system provides from complete automation of the process but can easily be overridden by manual control. The use of this cost effective system can provide process optimization and is an effective element in developing a viable in-situ technology.

Drug delivery interfaces in the 21st century: from science fiction ideas to viable technologies.

PubMed

Chertok, Beata; Webber, Matthew J; Succi, Marc D; Langer, Robert

2013-10-07

Early science fiction envisioned the future of drug delivery as targeted micrometer-scale submarines and "cyborg" body parts. Here we describe the progression of the field toward technologies that are now beginning to capture aspects of this early vision. Specifically, we focus on the two most prominent types of systems in drug delivery: the intravascular micro/nano drug carriers for delivery to the site of pathology and drug-loaded implantable devices that facilitate release with the predefined kinetics or in response to a specific cue. We discuss the unmet clinical needs that inspire these designs, the physiological factors that pose difficult challenges for their realization, and viable technologies that promise robust solutions. We also offer a perspective on where drug delivery may be in the next 50 years based on expected advances in material engineering and in the context of future diagnostics.

Drug Delivery Interfaces in the 21st Century: From Science Fiction Ideas to Viable Technologies

PubMed Central

Chertok, Beata; Webber, Matthew J.; Succi, Marc D.; Langer, Robert S.

2013-01-01

Early science fiction envisioned the future of drug delivery as targeted micron-scale submarines and ‘Cyborg’ body parts. Here we describe the progression of the field toward technologies that are now beginning to capture aspects of this early vision. Specifically, we focus on the two most prominent types of systems in drug delivery – the intravascular micro/nano drug carriers for delivery to the site of pathology and drug-loaded implantable devices that facilitate release with the pre-defined kinetics or in response to a specific cue. We discuss the unmet clinical needs that inspire these designs, the physiological factors that pose difficult challenges for their realization, and viable technologies that promise robust solutions. We also offer a perspective on where drug delivery may be in the next 50 years based on expected advances in material engineering and in the context of future diagnostics. PMID:23915375

SOLUTIONS TO OVERCOME BARRIERS TO IMPLEMENTATION OF TREATMENT TECHNOLOGIES

EPA Science Inventory

To make treatment a viable option for remediation you must first identify the barriers to implementing treatment. The primary barrier is economics. Treatment options are relatively expensive and there is a lack of funds for treatment. The cost of technologies can be lowered by 1)...

The science, development, and commercialization of postharvest biocontrol products

USDA-ARS?s Scientific Manuscript database

Postharvest biological control agents as a viable alternative to the use of synthetic chemicals have been the focus of considerable research for the last 30 years by many scientists and several commercial companies worldwide. Several antagonists of postharvest pathogens have been identified and tes...

21st Century Water Asset Accounting - Case Studies Report (WERF Report INFR6R12a)

EPA Science Inventory

America’s decaying water infrastructure presents significant financial and logistical challenges for water utilities. Green infrastructure has been gaining traction as a viable alternative and complement to traditional “grey” infrastructure for water management. Current accounti...

PROJECTING WILDLIFE RESPONSES TO ALTERNATIVE FUTURE LANDSCAPES IN OREGON'S WILLAMETTE VALLEY

EPA Science Inventory

Increasingly, environmental quality is becoming recognized as a critical factor that should constrain land use planning. One important measure of a landscape's quality is its capacity to support viable populations of wildlife species. But the ability of land managers to balance c...

DEMONSTRATION OF WATERBASED PLATEN ADHESIVES FOR GARMENT SCREEN PRINTERS

EPA Science Inventory

The paper discusses a demonstration of waterbased platen adhesives as a viable alternative to the organic-based aerosol adhesives that are predominantly used by garment screen printers to affix garments or fabric pieces to print platens. o demonstrate this, the effectiveness of s...

Development of a 1-m Class Telescope at TMF to Support Optical Communications Demonstrations

NASA Technical Reports Server (NTRS)

Wilson, K. E.; Sandusky, J.

1998-01-01

With the impetus towards high data rate communications in inter-satellite and space-to-ground links, the small size, low-mass, and low-power consumption of optical communications is seen as a viable alternative to radio frequency links.

76 FR 66758 - Remedies for Small Copyright Claims

Federal Register 2010, 2011, 2012, 2013, 2014

2011-10-27

... legal system hinders or prevents copyright owners from pursuing copyright infringement claims that have... helpful and viable. A. Challenges of the Current Legal System Currently, copyright owners interested in... Office is interested in learning about alternatives to the current legal system that might help alleviate...

Social Studies in the Nuclear Age: The Doomsday Issue.

ERIC Educational Resources Information Center

Kahn, Andrew Lerner

1984-01-01

A major nuclear exchange between America and the Soviet Union would probably result in the total annihilation of humankind. Social studies educators have a special responsibility to their students to search out all viable alternatives to nuclear deterrence and to make them known. (RM)

Wireless global positioning system fleet tracking system at the University at Albany.

DOT National Transportation Integrated Search

2014-07-01

This report provides an overview of the project undertaken at the University at Albany to make alternative transportation a more : viable option by implementing a GPS Tracking System on the University bus fleet and broadcasting the bus locations to c...

Microsilica modified concrete for bridge deck overlays : first-year interim report.

DOT National Transportation Integrated Search

1991-11-01

The study objective was to see if microsilica concrete (MC) is a viable alternative to the latex modified concrete (LMC) usually used on bridge deck overlays in Oregon. The study addresses MC overlays placed in 1989 on 7 portland cement concrete (PCC...

Public Education in Rural America.

ERIC Educational Resources Information Center

Sher, Jonathan P.; And Others

Like agriculture, public education in rural America has increasingly moved away from a small community orientation to larger consolidations. The forces of modernization, consolidation, and urbanization challenge the rural community to create a pragmatically viable alternative to the metropolitan way of life, because by adopting urban practices and…

Financial appraisal of wet mesophilic AD technology as a renewable energy and waste management technology.

PubMed

Dolan, T; Cook, M B; Angus, A J

2011-06-01

Anaerobic digestion (AD) has the potential to support diversion of organic waste from landfill and increase renewable energy production. However, diffusion of this technology has been uneven, with countries such as Germany and Sweden taking the lead, but limited diffusion in other countries such as the UK. In this context, this study explores the financial viability of AD in the UK to offer reasons why it has not been more widely used. This paper presents a model that calculates the Internal Rate of Return (IRR) on a twenty year investment in a 30,000 tonnes per annum wet mesophilic AD plant in the UK for the treatment of source separated organic waste, which is judged to be a suitable technology for the UK climate. The model evaluates the financial significance of the different alternative energy outputs from this AD plant and the resulting economic subsidies paid for renewable energy. Results show that renewable electricity and renewable heat sales supported by renewable electricity and renewable heat tariffs generates the greatest IRR (31.26%). All other uses of biogas generate an IRR in excess of 15%, and are judged to be a financially viable investment. Sensitivity analysis highlights the financial significance of: economic incentive payments and a waste management gate fee; and demonstrates that the fate of the digestate by-product is a source of financial uncertainty for AD investors. Copyright © 2011 Elsevier B.V. All rights reserved.

Benchmarking the expected stack manufacturing cost of next generation, intermediate-temperature protonic ceramic fuel cells with solid oxide fuel cell technology

NASA Astrophysics Data System (ADS)

Dubois, Alexis; Ricote, Sandrine; Braun, Robert J.

2017-11-01

Recent progress in the performance of intermediate temperature (500-600 °C) protonic ceramic fuel cells (PCFCs) has demonstrated both fuel flexibility and increasing power density that approach commercial application requirements. These developments may eventually position the technology as a viable alternative to solid oxide fuel cells (SOFCs) and molten carbonate fuel cells (MCFCs). The PCFCs investigated in this work are based on a BaZr0.8Y0.2O3-δ (BZY20) thin electrolyte supported by BZY20/Ni porous anodes, and a triple conducting cathode material comprised of BaCo0.4Fe0.4Zr0.1Y0.1O3-δ (BCFZY0.1). These cells are prepared using a low-cost solid-state reactive sintering (SSRS) process, and are capable of power densities of 0.156 W cm-2 at 500 °C operating directly from methane fuel. We develop a manufacturing cost model to estimate the Nth generation production costs of PCFC stack technology using high volume manufacturing processes and compare them to the state-of-the-art in SOFC technology. The low-cost cell manufacturing enabled by the SSRS technique compensates for the lower PCFC power density and the trade-off between operating temperature and efficiency enables the use of lower-cost stainless steel materials. PCFC stack production cost estimates are found to be as much as 27-37% lower at 550 °C than SOFCs operating at 800 °C.

Composting, anaerobic digestion and biochar production in Ghana. Environmental–economic assessment in the context of voluntary carbon markets

DOE Office of Scientific and Technical Information (OSTI.GOV)

Galgani, Pietro, E-mail: p.galgani@hotmail.com; Voet, Ester van der; Korevaar, Gijsbert

2014-12-15

Highlights: • Economic–environmental assessment of combining composting with biogas and biochar in Ghana. • These technologies can save greenhouse gas emissions for up to 0.57 t CO{sub 2} eq/t of waste treated. • Labor intensive, small-scale organic waste management is not viable without financial support. • Carbon markets would make these technologies viable with carbon prices in the range of 30–84 EUR/t. - Abstract: In some areas of Sub-Saharan Africa appropriate organic waste management technology could address development issues such as soil degradation, unemployment and energy scarcity, while at the same time reducing emissions of greenhouse gases. This paper investigatesmore » the role that carbon markets could have in facilitating the implementation of composting, anaerobic digestion and biochar production, in the city of Tamale, in the North of Ghana. Through a life cycle assessment of implementation scenarios for low-tech, small scale variants of the above mentioned three technologies, the potential contribution they could give to climate change mitigation was assessed. Furthermore an economic assessment was carried out to study their viability and the impact thereon of accessing carbon markets. It was found that substantial climate benefits can be achieved by avoiding landfilling of organic waste, producing electricity and substituting the use of chemical fertilizer. Biochar production could result in a net carbon sequestration. These technologies were however found not to be economically viable without external subsidies, and access to carbon markets at the considered carbon price of 7 EUR/ton of carbon would not change the situation significantly. Carbon markets could help the realization of the considered composting and anaerobic digestion systems only if the carbon price will rise above 75–84 EUR/t of carbon (respectively for anaerobic digestion and composting). Biochar production could achieve large climate benefits and, if approved as a land based climate mitigation mechanism in carbon markets, it would become economically viable at the lower carbon price of 30 EUR/t of carbon.« less

Catalysts for Change: The Role of Small Business Funders in the Creation and Dissemination of Innovation

ERIC Educational Resources Information Center

Shic, Frederick; Smith, Daniel; Horsburgh, Brian; Hollander, Eric; Rehg, James M.; Goodwin, Matthew

2015-01-01

A gap exists between the expanding space of technological innovations to aid those affected by autism spectrum disorders, and the actual impact of those technologies on daily lives. This gap can be addressed through a very practical path of commercialization. However, the path from a technological innovation to a commercially viable product is…

Free space optics: a viable last-mile alternative

NASA Astrophysics Data System (ADS)

Willebrand, Heinz A.; Clark, Gerald R.

2001-10-01

This paper explores Free Space Optics (FSO) as an access technology in the last mile of metropolitan area networks (MANs). These networks are based in part on fiber-optic telecommunications infrastructure, including network architectures of Synchronous Optical Network (commonly referred to as SONET), the North American standard for synchronous data transmission; and Synchronous Digital Hierarchy (commonly referred to as SDH), the international standard and equivalent of SONET. Several converging forces have moved FSO beyond a niche technology for use only in local area networks (LANs) as a bridge connecting two facilities. FSO now allows service providers to cost effectively provide optical bandwidth for access networks and accelerate the extension of metro optical networks bridging what has been termed by industry experts as the optical dead zone. The optical dead zone refers to both the slowdown in capital investment in the short-term future and the actual connectivity gap that exists today between core metro optical networks and the access optical networks. Service providers have built extensive core and minimal metro networks but have not yet provided optical bandwidth to the access market largely due to the non-compelling economics to bridge the dead zone with fiber. Historically, such infrastructure build-out slowdowns have been blamed on a combination of economics, time-to-market constraints and limited technology options. However, new technology developments and market acceptance of FSO give service providers a new cost-effective alternative to provide high-bandwidth services with optical bandwidth in the access networks. Merrill Lynch predicts FSO will grow into a $2 billion market by 2005. The drivers for this market are a mere 5%- 6% penetration of fiber to business buildings; cost effective solution versus RF or fiber; and significant capacity which can only be matched by a physical fiber link, Merrill Lynch reports. This paper will describe FSO technology, its capabilities and its limitations. The paper will investigate how FSO technology has evolved to its current stage for deployment in MANs, LANs, wireless backhaul and metropolitan network extensions - applications that fall within the category of last mile. The paper will address the market, drivers and the adoption of FSO, plus provide a projection of future FSO technology, based on today's product roadmaps. The paper concludes with a summary of findings and recommendations.

MotorWeek

ScienceCinema

None

2017-12-27

In 2008, PBS's MotorWeek, television's original automotive magazine, visited Argonne's Transportation Technology R&D Center "To learn what it really takes to make clean power sources a viable reality."

The Future of Product Design Utilising Printed Electronics

ERIC Educational Resources Information Center

York, Nicola; Southee, Darren; Evans, Mark

2017-01-01

This paper addresses the teaching of emerging technologies to design students, using "printed electronics" as an example as it recently became viable to mass manufacture and is ready for use in designs. Printed electronics is introduced as a disruptive technology, and approaches employed in knowledge transfer to industrial/product…

On Basic Needs and Modest Media.

ERIC Educational Resources Information Center

Gunter, Jock

1978-01-01

The need for grass-roots participation and local control in whatever technology is used to meet basic educational needs is stressed. Successful uses of the audio cassette recorder and the portable half-inch video recorder are described; the 8-mm sound camera and video player are also suggested as viable "modest" technologies. (JEG)

Laser assisted deposition

NASA Technical Reports Server (NTRS)

Dutta, S.

1983-01-01

Applications of laser-based processing techniques to solar cell metallization are discussed. Laser-assisted thermal or photolytic maskless deposition from organometallic vapors or solutions may provide a viable alternative to photovoltaic metallization systems currently in use. High power, defocused excimer lasers may be used in conjunction with masks as an alternative to direct laser writing to provide higher throughput. Repeated pulsing with excimer lasers may eliminate the need for secondary plating techniques for metal film buildup. A comparison between the thermal and photochemical deposition processes is made.

Emergent Rules for Codon Choice Elucidated by Editing Rare Arginine Codons in Escherichia coli

DTIC Science & Technology

2016-09-20

alternative codons are more likely to be viable. To evaluate synonymous and nonsynonymous alternatives to essential AGRs further, we imple- mented a CRISPR ... Crispr -assisted MAGE). First, we designed oligos that changed not only the target AGR codon to NNN but also made several synonymous changes at least 50...nt downstream that would disrupt a 20-bp CRISPR target lo- cus. MAGE was used to replace each AGR with NNN in parallel, and CRISPR /cas9 was used to

Alternative Dispute Resolution : A Viable Method for Settling Government Contract Disputes

DTIC Science & Technology

1993-06-01

S. Rept. 543, 101st Congress, 2d Session. 14. Page, Reba and Lees, Frederick J., "Roles of Participants in Mini-Trial," Public Contract Law Journal...15. Brittin, Alexander J., "Alternative Dispute Resolution in Government Contract Appeals," Public Contract Law Journal. 16. Dauer, "Litigation v...International Law and Economics. Vol. 20, No. 3, 1987. 22. Page, Reba and Lees, Frederick J., "Roles of Participants in Mini-Trial," Public Contract Law Journal

Human Exploration of the Solar System by 2100

NASA Technical Reports Server (NTRS)

Litchford, Ronald J.

2017-01-01

It has been suggested that the U.S., in concert with private entities and international partners, set itself on a course to accomplish human exploration of the solar system by the end of this century. This is a strikingly bold vision intended to revitalize the aspirations of HSF in service to the security, economic, and scientific interests of the nation. Solar system distance and time scales impose severe requirements on crewed space transportation systems, however, and fully realizing all objectives in support of this goal will require a multi-decade commitment employing radically advanced technologies - most prominently, space habitats capable of sustaining and protecting life in harsh radiation environments under zero gravity conditions and in-space propulsion technologies capable of rapid deep space transits with earth return, the subject of this paper. While near term mission destinations such as the moon and Mars can be accomplished with chemical propulsion and/or high power SEP, fundamental capability constraints render these traditional systems ineffective for solar system wide exploration. Nuclear based propulsion and alternative energetic methods, on the other hand, represent potential avenues, perhaps the only viable avenues, to high specific power space transport evincing reduced trip time, reduced IMLEO, and expanded deep space reach. Here, very long term HSF objectives for solar system wide exploration are examined in relation to the advanced propulsion technology solution landscape including foundational science, technical/engineering challenges, and developmental prospects.

The Making of a Lunar Outpost - Exploring a Future Case Study

NASA Astrophysics Data System (ADS)

Lewis, Ruthan; Micheels, Kurt; Dankewicz, Cathy

2007-01-01

Buildup and development of a lunar outpost / base will be an incremental and alternated process of crew, logistics, hardware, and science payload deliveries. To better plan the resources and technological objectives for each increment, one may examine the operational and technological requirements for a ``midterm'' phase and project backwards to derive and strategize requirements and resources for each stage of the development. This comprehensive characterization of the midterm phase will ultimately provide the waypoint by which later development phases can be more effectively planned. A unique and critical engineering and architectural view of a midterm waypoint and the roadmap to achieve the goals and capabilities at that milestone was generated. Data to derive the process and midterm outpost design was acquired during a recent comprehensive National Aeronautics and Space Administration (NASA) research project. Current and soon to be state-of-the-art, viable, proven technologies to support an effective and resourceful outpost design including rigidizable, inflatable structures, hybridized in-situ and imported materials utilization, and environmentally-responsive structures considering thermal, radiation, topographical, low-gravity, crew and transport mobility, habitability, and logistics aspects were investigated and applied. Adjacency analyses were performed to optimize the arrangement of spaces. Additionally, an inventive, internal, organizational architectural system that maps and coordinates lunar and Earth contingency planning configurations and activities, and assists fabrication and layout processes and techniques was derived.

Emergent rules for codon choice elucidated by editing rare arginine codons in Escherichia coli

PubMed Central

Napolitano, Michael G.; Landon, Matthieu; Gregg, Christopher J.; Lajoie, Marc J.; Govindarajan, Lakshmi; Mosberg, Joshua A.; Kuznetsov, Gleb; Goodman, Daniel B.; Vargas-Rodriguez, Oscar; Isaacs, Farren J.; Söll, Dieter; Church, George M.

2016-01-01

The degeneracy of the genetic code allows nucleic acids to encode amino acid identity as well as noncoding information for gene regulation and genome maintenance. The rare arginine codons AGA and AGG (AGR) present a case study in codon choice, with AGRs encoding important transcriptional and translational properties distinct from the other synonymous alternatives (CGN). We created a strain of Escherichia coli with all 123 instances of AGR codons removed from all essential genes. We readily replaced 110 AGR codons with the synonymous CGU codons, but the remaining 13 “recalcitrant” AGRs required diversification to identify viable alternatives. Successful replacement codons tended to conserve local ribosomal binding site-like motifs and local mRNA secondary structure, sometimes at the expense of amino acid identity. Based on these observations, we empirically defined metrics for a multidimensional “safe replacement zone” (SRZ) within which alternative codons are more likely to be viable. To evaluate synonymous and nonsynonymous alternatives to essential AGRs further, we implemented a CRISPR/Cas9-based method to deplete a diversified population of a wild-type allele, allowing us to evaluate exhaustively the fitness impact of all 64 codon alternatives. Using this method, we confirmed the relevance of the SRZ by tracking codon fitness over time in 14 different genes, finding that codons that fall outside the SRZ are rapidly depleted from a growing population. Our unbiased and systematic strategy for identifying unpredicted design flaws in synthetic genomes and for elucidating rules governing codon choice will be crucial for designing genomes exhibiting radically altered genetic codes. PMID:27601680

MAMMALIAN APOPTOSIS IN WHOLE NEONATAL OVARIES, EMBRYOS AND FETAL LIMBS USING CONFOCAL MICROSCOPY

EPA Science Inventory

The emergence of confocal laser scanning microscopy (CLSM) as a technique capable of optically generating serial sections of whole-mount tissue and then reassembling the computer-stored images as a virtual 3-dimensional structure offers a viable alternative to traditional section...

In Response to Rowland on "Realism and Debateability in Policy Advocacy."

ERIC Educational Resources Information Center

Herbeck, Dale A.; Katsulas, John P.

1986-01-01

Argues that Robert Rowland has overstated the case against the permutation process for assessing counterplan competitiveness. Claims that the permutation standard is a viable method for ascertaining counterplan competitiveness. Examines Rowland's alternative and argues that it is an unsatisfactory method for determining counterplan…

Understanding commuter patterns and behavior : an analysis to recommend policies aimed at reducing vehicle use.

DOT National Transportation Integrated Search

2010-08-01

The objective of the study was to make alternative transportation a more viable option by identifying commuting preferences and patterns in order to recommend policies aimed at reducing vehicle miles travelled. This study focused on the use of single...

Culture-Specific Testing: Part 1.

ERIC Educational Resources Information Center

Williams, Robert L., Ed.

1981-01-01

In five articles provides a rationale for the development of culturally specific tests, presents research on their use, and discusses clinical uses. Focuses on two Afro-centric projective tests: The Thematic Apperception Test and Themes Concerning Blacks. Criticizes use of traditional projective tests and points out viable alternatives. (JAC)

Alternative Test Methods for Developmental Neurotoxicity: A History and Path Forward (OECD EFSA workshop)

EPA Science Inventory

Exposure to environmental contaminants is well documented to adversely impact the development of the nervous system. However, the time, animal and resource intensive EPA and OECD testing guideline methods for developmental neurotoxicity (DNT) are not a viable solution to characte...

Fluorescence particle detector for real-time quantification of viable organisms in air

NASA Astrophysics Data System (ADS)

Luoma, Greg; Cherrier, Pierre P.; Piccioni, Marc; Tanton, Carol; Herz, Steve; DeFreez, Richard K.; Potter, Michael; Girvin, Kenneth L.; Whitney, Ronald

2002-02-01

The ability to detect viable organisms in air in real time is important in a number of applications. Detecting high levels of airborne organisms in hospitals can prevent post-operative infections and the spread of diseases. Monitoring levels of airborne viable organisms in pharmaceutical facilities can ensure safe production of drugs or vaccines. Monitoring airborne bacterial levels in meat processing plants can help to prevent contamination of food products. Monitoring the level of airborne organisms in bio-containment facilities can ensure that proper procedures are being followed. Finally, detecting viable organisms in real time is a key to defending against biological agent attacks. This presentation describes the development and performance of a detector, based on fluorescence particle counting technology, where an ultraviolet laser is used to count particles by light scattering and elicit fluorescence from specific biomolecules found only in living organisms. The resulting detector can specifically detect airborne particles containing living organisms from among the large majority of other particles normally present in air. Efforts to develop the core sensor technology, focusing on integrating an UV laser with a specially designed particle-counting cell will be highlighted. The hardware/software used to capture the information from the sensor, provide an alarm in the presence of an unusual biological aerosol content will also be described. Finally, results from experiments to test the performance of the detector will be presented.

Microalgal biomass production pathways: evaluation of life cycle environmental impacts

PubMed Central

2013-01-01

Background Microalgae are touted as an attractive alternative to traditional forms of biomass for biofuel production, due to high productivity, ability to be cultivated on marginal lands, and potential to utilize carbon dioxide (CO2) from industrial flue gas. This work examines the fossil energy return on investment (EROIfossil), greenhouse gas (GHG) emissions, and direct Water Demands (WD) of producing dried algal biomass through the cultivation of microalgae in Open Raceway Ponds (ORP) for 21 geographic locations in the contiguous United States (U.S.). For each location, comprehensive life cycle assessment (LCA) is performed for multiple microalgal biomass production pathways, consisting of a combination of cultivation and harvesting options. Results Results indicate that the EROIfossil for microalgae biomass vary from 0.38 to 1.08 with life cycle GHG emissions of −46.2 to 48.9 (g CO2 eq/MJ-biomass) and direct WDs of 20.8 to 38.8 (Liters/MJ-biomass) over the range of scenarios analyzed. Further anaylsis reveals that the EROIfossil for production pathways is relatively location invariant, and that algae’s life cycle energy balance and GHG impacts are highly dependent on cultivation and harvesting parameters. Contrarily, algae’s direct water demands were found to be highly sensitive to geographic location, and thus may be a constraining factor in sustainable algal-derived biofuel production. Additionally, scenarios with promising EROIfossil and GHG emissions profiles are plagued with high technological uncertainty. Conclusions Given the high variability in microalgae’s energy and environmental performance, careful evaluation of the algae-to-fuel supply chain is necessary to ensure the long-term sustainability of emerging algal biofuel systems. Alternative production scenarios and technologies may have the potential to reduce the critical demands of biomass production, and should be considered to make algae a viable and more efficient biofuel alternative. PMID:23786775

Launch Vehicles Based on Advanced Hybrid Rocket Motors: An Enabling Technology for the Commercial Small and Micro Satellite Planetary Science

NASA Astrophysics Data System (ADS)

Karabeyoglu, Arif; Tuncer, Onur; Inalhan, Gokhan

2016-07-01

Mankind is relient on chemical propulsion systems for space access. Nevertheless, this has been a stagnant area in terms of technological development and the technology base has not changed much almost for the past forty years. This poses a vicious circle for launch applications such that high launch costs constrain the demand and low launch freqencies drive costs higher. This also has been a key limiting factor for small and micro satellites that are geared towards planetary science. Rather this be because of the launch frequencies or the costs, the access of small and micro satellites to orbit has been limited. With today's technology it is not possible to escape this circle. However the emergence of cost effective and high performance propulsion systems such as advanced hybrid rockets can decrease launch costs by almost an order or magnitude. This paper briefly introduces the timeline and research challenges that were overcome during the development of advanced hybrid LOX/paraffin based rockets. Experimental studies demonstrated effectiveness of these advanced hybrid rockets which incorporate fast burning parafin based fuels, advanced yet simple internal balistic design and carbon composite winding/fuel casting technology that enables the rocket motor to be built from inside out. A feasibility scenario is studied using these rocket motors as building blocks for a modular launch vehicle capable of delivering micro satellites into low earth orbit. In addition, the building block rocket motor can be used further solar system missions providing the ability to do standalone small and micro satellite missions to planets within the solar system. This enabling technology therefore offers a viable alternative in order to escape the viscous that has plagued the space launch industry and that has limited the small and micro satellite delivery for planetary science.

Telestroke a viable option to improve stroke care in India.

PubMed

Srivastava, Padma V; Sudhan, Paulin; Khurana, Dheeraj; Bhatia, Rohit; Kaul, Subash; Sylaja, P N; Moonis, Majaz; Pandian, Jeyaraj Durai

2014-10-01

In India, stroke care services are not well developed. There is a need to explore alternative options to tackle the rising burden of stroke. Telemedicine has been used by the Indian Space Research Organization (ISRO) to meet the needs of remote hospitals in India. The telemedicine network implemented by ISRO in 2001 presently stretches to around 100 hospitals all over the country, with 78 remote/rural/district health centers connected to 22 specialty hospitals in major cities, thus providing treatment to more than 25 000 patients, which includes stroke patients. Telemedicine is currently used in India for diagnosing stroke patients, subtyping stroke as ischemic or hemorrhagic, and treating accordingly. However, a dedicated telestroke system for providing acute stroke care is needed. Keeping in mind India's flourishing technology sector and leading communication networks, the hub-and-spoke model could work out really well in the upcoming years. Until then, simpler alternatives like smartphones, online data transfer, and new mobile applications like WhatsApp could be used. Telestroke facilities could increase the pool of patients eligible for thrombolysis. But this primary aim of telestroke can be achieved in India only if thrombolysis and imaging techniques are made available at all levels of health care. © 2014 World Stroke Organization.

Advances in the local and targeted delivery of anti-infective agents for management of osteomyelitis.

PubMed

Ford, Caleb A; Cassat, James E

2017-09-01

Osteomyelitis, a common and debilitating invasive infection of bone, is a frequent complication following orthopedic surgery and causes pathologic destruction of skeletal tissues. Bone destruction during osteomyelitis results in necrotic tissue, which is poorly penetrated by antibiotics and can serve as a nidus for relapsing infection. Osteomyelitis therefore frequently necessitates surgical debridement procedures, which provide a unique opportunity for targeted delivery of antimicrobial and adjunctive therapies. Areas covered: Following surgical debridement, tissue voids require implanted materials to facilitate the healing process. Antibiotic-loaded, non-biodegradable implants have been the standard of care. However, a new generation of biodegradable, osteoconductive materials are being developed. Additionally, in the face of widespread antimicrobial resistance, alternative therapies to traditional antibiotic regimens are being investigated, including bone targeting compounds, antimicrobial surface modifications of orthopedic implants, and anti-virulence strategies. Expert commentary: Recent advances in biodegradable drug delivery scaffolds make this technology an attractive alternative to traditional techniques for orthopedic infection that require secondary operations for removal. Advances in novel treatment methods are expanding the arsenal of viable antimicrobial treatment strategies in the face of widespread drug resistance. Despite a need for large scale clinical investigations, these strategies offer hope for future treatment of this difficult invasive disease.

Impedance-based cellular assays for regenerative medicine.

PubMed

Gamal, W; Wu, H; Underwood, I; Jia, J; Smith, S; Bagnaninchi, P O

2018-07-05

Therapies based on regenerative techniques have the potential to radically improve healthcare in the coming years. As a result, there is an emerging need for non-destructive and label-free technologies to assess the quality of engineered tissues and cell-based products prior to their use in the clinic. In parallel, the emerging regenerative medicine industry that aims to produce stem cells and their progeny on a large scale will benefit from moving away from existing destructive biochemical assays towards data-driven automation and control at the industrial scale. Impedance-based cellular assays (IBCA) have emerged as an alternative approach to study stem-cell properties and cumulative studies, reviewed here, have shown their potential to monitor stem-cell renewal, differentiation and maturation. They offer a novel method to non-destructively assess and quality-control stem-cell cultures. In addition, when combined with in vitro disease models they provide complementary insights as label-free phenotypic assays. IBCA provide quantitative and very sensitive results that can easily be automated and up-scaled in multi-well format. When facing the emerging challenge of real-time monitoring of three-dimensional cell culture dielectric spectroscopy and electrical impedance tomography represent viable alternatives to two-dimensional impedance sensing.This article is part of the theme issue 'Designer human tissue: coming to a lab near you'. © 2018 The Author(s).

Using endometrial ablation as a treatment for abnormal bleeding: energy source comparisons and clinical results

NASA Astrophysics Data System (ADS)

Ryan, Thomas P.

2000-01-01

A great number of women suffer from abnormal uterine bleeding. Most do not want to undergo a hysterectomy and have searched for an alternative treatment. Ablation of the endometrium has become a viable alternative. Initially, surgical applications utilized thermal ablation by passing a rolling electrode, energized by monopolar radiofrequency (RF) energy, to ablate the inner uterine lining. This procedure was done under visual guidance and required practiced surgical skills to perform the ablation. It was not possible to assess subsurface damage. More recently, various energy systems have been applied to the endometrium such as lasers, microwaves, monopolar and bipolar RF, hot fluid balloons, and cryotherapy. They are being used in computer controlled treatments that obviate the user's skill, and utilize a self-positioning device paired with a temperature monitored, thermal treatment. Finite element models have also been created to predict heating profiles with devices that either rely on conductive heating or that deposit power in tissue. This is a very active field in terms of innovation with creative solutions using contemporary technology to reduce or halt the bleeding. Devices and minimally invasive treatments will offer choices to women and will be able to replace a surgical procedure with an office-based procedure. They are very promising and are discussed at length herein.

Advances in the Local and Targeted Delivery of Anti-infective Agents for Management of Osteomyelitis

PubMed Central

Ford, Caleb A.; Cassat, James E.

2018-01-01

Structured Abstract Introduction Osteomyelitis, a common and debilitating invasive infection of bone, is a frequent complication following orthopedic surgery and causes pathologic destruction of skeletal tissues. Bone destruction during osteomyelitis results in necrotic tissue, which is poorly penetrated by antibiotics and can serve as a nidus for relapsing infection. Osteomyelitis therefore frequently necessitates surgical debridement procedures, which provide a unique opportunity for targeted delivery of antimicrobial and adjunctive therapies. Areas Covered Following surgical debridement, tissue voids require implanted materials to facilitate the healing process. Antibiotic-loaded, non-biodegradable implants have been the standard of care. However, a new generation of biodegradable, osteoconductive materials are being developed. Additionally, in the face of widespread antimicrobial resistance, alternative therapies to traditional antibiotic regimens are being investigated, including bone targeting compounds, antimicrobial surface modifications of orthopedic implants, and anti-virulence strategies. Expert Commentary Recent advances in biodegradable drug delivery scaffolds make this technology an attractive alternative to traditional techniques for orthopedic infection that require secondary operations for removal. Advances in novel treatment methods are expanding the arsenal of viable antimicrobial treatment strategies in the face of widespread drug resistance. Despite a need for large scale clinical investigations, these strategies offer hope for future treatment of this difficult invasive disease. PMID:28837368

High pressure inactivation of Brettanomyces bruxellensis in red wine.

PubMed

van Wyk, Sanelle; Silva, Filipa V M

2017-05-01

Brettanomyces bruxellensis ("Brett") is a major spoilage concern for the wine industry worldwide, leading to undesirable sensory properties. Sulphur dioxide, is currently the preferred method for wine preservation. However, due to its negative effects on consumers, the use of new alternative non-thermal technologies are increasingly being investigated. The aim of this study was to determine and model the effect of high pressure processing (HPP) conditions and yeast strain on the inactivation of "Brett" in Cabernet Sauvignon wine. Processing at 200 MPa for 3 min resulted in 5.8 log reductions. However higher pressure is recommended to achieve high throughput in the wine industry, for example >6.0 log reductions were achieved after 400 MPa for 5 s. The inactivation of B. bruxellensis is pressure and time dependent, with increased treatment time and pressure leading to increased yeast inactivation. It was also found that yeast strain had a significant effect on HPP inactivation, with AWRI 1499 being the most resistant strain. The Weibull model successfully described the HPP "Brett" inactivation. HPP is a viable alternative for the inactivation of B. bruxellensis in wine, with the potential to reduce the industry's reliance on sulphur dioxide. Copyright © 2016 Elsevier Ltd. All rights reserved.

The Role of Motive Objects in Early Childhood Teacher Development Concerning Children's Digital Play and Play-Based Learning in Early Childhood Curricula

ERIC Educational Resources Information Center

Nuttall, Joce; Edwards, Susan; Mantilla, Ana; Grieshaber, Sue; Wood, Elizabeth

2015-01-01

Digital technologies are increasingly accepted as a viable aspect of early childhood curriculum. However, teacher uptake of digital technologies in early childhood education and their use with young children in play-based approaches to learning have not been strong. Traditional approaches to the problem of teacher uptake of digital technologies in…

Capabilities | Transportation Research | NREL

Science.gov Websites

about: Energy storage Power electronics Climate control Medium- and Heavy-Duty Vehicle Technology viable in the marketplace. Learn more about: Power electronics Energy storage Transportation Data

Single-Case Experimental Designs: A Systematic Review of Published Research and Current Standards

ERIC Educational Resources Information Center

Smith, Justin D.

2012-01-01

This article systematically reviews the research design and methodological characteristics of single-case experimental design (SCED) research published in peer-reviewed journals between 2000 and 2010. SCEDs provide researchers with a flexible and viable alternative to group designs with large sample sizes. However, methodological challenges have…

The Latent Variable Approach as Applied to Transitive Reasoning

ERIC Educational Resources Information Center

Bouwmeester, Samantha; Vermunt, Jeroen K.; Sijtsma, Klaas

2012-01-01

We discuss the limitations of hypothesis testing using (quasi-) experiments in the study of cognitive development and suggest latent variable modeling as a viable alternative to experimentation. Latent variable models allow testing a theory as a whole, incorporating individual differences with respect to developmental processes or abilities in the…

Establishment of perennial grass species for cellulosic biofuel production in Georgia

USDA-ARS?s Scientific Manuscript database

In order for biofuels to become a viable alternative energy source in the state of Georgia, appropriate feed stocks must be developed to supply this burgeoning industry. Georgia is optimum for biomass production because of its warm subtropical climate, large number of growing degree days, and an es...

Community outreach: rural mobile health unit.

PubMed

Alexy, B B; Elnitsky, C A

1996-12-01

With the increased emphasis on cost containment, hospital administrators are investigating community outreach projects to remain economically viable. The authors describe the planning and implementation of a mobile health unit for rural elderly residents. This project represents an alternative model of healthcare delivery in a rural area with limited resources and healthcare providers.

Simulated and Virtual Science Laboratory Experiments: Improving Critical Thinking and Higher-Order Learning Skills

ERIC Educational Resources Information Center

Simon, Nicole A.

2013-01-01

Virtual laboratory experiments using interactive computer simulations are not being employed as viable alternatives to laboratory science curriculum at extensive enough rates within higher education. Rote traditional lab experiments are currently the norm and are not addressing inquiry, Critical Thinking, and cognition throughout the laboratory…

Hydrogenated cottonseed oil as raw material for biobased materials

USDA-ARS?s Scientific Manuscript database

There has been a lot of recent interest in using vegetable oils as biodegradable and renewable raw materials for the syntheses of various biobased materials. Although most of the attention has been paid to soybean oil thus far, cottonseed oil is a viable alternative. An advantage of cottonseed oil...

The Impact of Microcomputers on Composition Students.

ERIC Educational Resources Information Center

Hocking, Joan

To determine whether computer assisted instruction was just a fad or a viable alternative to traditional methods for teaching English composition, a microcomputer was used in a traditional college freshman English course. The class was divided into small groups: some went to the computer lab, while others worked in the classroom. Interactive…

New Challenges in Cross Domain Deterrence

DTIC Science & Technology

2018-06-01

Active and Passive Prior Refutation of Same and Alternative Counterarguments,” Journal of Abnormal Psychology , Vol. 63, No. 2, 1961. Miller, S. E., and...affordability, and maintaining the integrity of U.S. values may, in the end, cause punishment to be the only viable option. 92 For the concept of

Use of liquid/supercritical CO2 extraction process for butanol recovery from fermentation broth

USDA-ARS?s Scientific Manuscript database

In order for butanol fermentation to be a viable option, it is essential to recover it from fermentation broth using economical alternate in-situ product recovery techniques such as liquid/supercritical CO2 extraction as compared to distillation. This technique (liquid CO2 extraction & supercritical...

Hands-On Hydroponics

ERIC Educational Resources Information Center

Carver, Jeffrey; Wasserman, Bradley

2012-01-01

Hydroponics is a process in which plants are grown using nutrient-rich water instead of soil. Because this process maximizes the use of water and nutrients--providing only what the plant uses in controlled and easily maintained systems--it is a viable alternative to traditional farming methods. The amount of control in these systems also ensures…

Can Higher Education Stimulate Entrepreneurial Intentions among Engineering and Business Students?

ERIC Educational Resources Information Center

Herman, Emilia; Stefanescu, Daniela

2017-01-01

This paper approaches the issue of higher entrepreneurship education in motivating young people to start their own business as a viable alternative to the successful integration of university graduates on the labour market. The fundamental question of this research is if, currently, entrepreneurship education influences students' entrepreneurial…

Walking the Talk: The Complexities of Teaching about Teaching

ERIC Educational Resources Information Center

Ball, Tamara; Wells, Gordon

2006-01-01

Teaching a course entitled "Introduction to Theories of Education" requires that one practice what one is preaching. We describe an attempt to organize and provide undergraduates enrolled in an introductory course of 300+ students, with a viable, yet more collaborative and "product-based" alternative to the familiar lecture and…

Advances in Brassica seed meal formulation for apple replant disease control

USDA-ARS?s Scientific Manuscript database

Brassicaceae seed meals when used independently do not provide uniform and sufficient control of the pathogen complex that incites apple replant disease for this soil amendment to be used as a viable alternative to pre-plant soil fumigation. Therefore, field trials were established at multiple site...

Agrobacterium-Mediated Transformation of Bread and Durum Wheat Using Freshly Isolated Immature Embryos

NASA Astrophysics Data System (ADS)

Huixia, Wu; Angela, Doherty; Jones, Huw D.

Agrobacterium-mediated transformation of wheat is becoming a viable alternative to the more established biolistic protocols. It offers advantages in terms of simple, low-copy-number integrations and can be applied with similar efficiencies to specific durum wheat and spring and winter bread wheat types varieties.

Effects of E-Textbook Instructor Annotations on Learner Performance

ERIC Educational Resources Information Center

Dennis, Alan R.; Abaci, Serdar; Morrone, Anastasia S.; Plaskoff, Joshua; McNamara, Kelly O.

2016-01-01

With additional features and increasing cost advantages, e-textbooks are becoming a viable alternative to paper textbooks. One important feature offered by enhanced e-textbooks (e-textbooks with interactive functionality) is the ability for instructors to annotate passages with additional insights. This paper describes a pilot study that examines…

Castration is no laughing matter, nitrous oxide can’t even help

USDA-ARS?s Scientific Manuscript database

Castration of pigs is necessary since no other viable alternative is yet available. However, castration is painful and analgesics are being considered to relieve pain. Inhalant gases with analgesic properties allow for a fast induction, short-term and reversible effects, and are a needle-free option...

The Infusion of Corporate Values into Progressive Education: Professional Vulnerability or Complicity?

ERIC Educational Resources Information Center

Gamson, David A.

2004-01-01

Examines the history of educational administration in the USA during the Progressive era (1890-1940). Using Callahan's Education and the Cult of Efficiency as a starting point, examines school district-based administrative practices that offered viable alternatives to the business-oriented, "scientific management" reforms that tended to…

Tapping the US historic sweet sorghum collection to identify biofuel germplasm

USDA-ARS?s Scientific Manuscript database

Sweet sorghum [Sorghum bicolor (L.) Moench] has gained an important role as a viable alternative to fossil fuels and a more profitable option than maize and sugarcane. Nevertheless, the actual narrow genetic base in sweet sorghum breeding programs is limiting the development of new biofuel varietie...

Running Rings Around the Web.

ERIC Educational Resources Information Center

McDermott, Irene E.

1999-01-01

Describes the development and current status of WebRing, a service that links related Web sites into a central hub. Discusses it as a viable alternative to other search engines and examines issues of free speech, use by the business sector, and implications for WebRing after its purchase by Yahoo! (LRW)

Ebook Approval Plans: Integration to Meet User Needs

ERIC Educational Resources Information Center

Buckley, Matthew; Tritt, Deborah

2011-01-01

Within academic library collections, electronic journals are a mainstay. Ebooks, on the other hand, have established themselves as a viable alternative to the print book more slowly. The growing acceptance and prevalence of ebooks cannot be ignored. As libraries continue to build their collections, ebooks play an increasingly larger role in…

Analyzing clonal fidelity of micropropagated Psidium guajava L. plants using simple sequence repeat markers

USDA-ARS?s Scientific Manuscript database

Micropropagation of Psidium guajava L. (guava) is a viable alternative to currently adopted techniques for large-scale plant propagation of commercial cultivars. Assessment of clonal fidelity in micropropagated plants is the first step towards ensuring genetic uniformity in mass production of planti...

Tax-exempt private placements: a new opportunity for not-for-profit providers.

PubMed

Ambrose, Jim; Harris, Andrew

2006-08-01

Tax-exempt private placements offer an attractive financing alternative for not-for-profit healthcare providers for which the public debt market is no longer a viable option. They offer the following advantages: Greater flexibility Lower fees. Less paperwork. Fewer players. Shorter time to complete.

Voluntary Childlessness: A Neglected Area of Family Study

ERIC Educational Resources Information Center

Veevers, J. E.

1973-01-01

Empirical research on childlessness would provide a necessary control group for analyses of motivations for parenthood, and of the effects of children on personal and marital adjustment. Knowledge of the conditions under which voluntary childlessness constitutes a viable and satisfactory alternate life style would have implications for more…

Cultural Assumptions against Sustainability: An International Survey

ERIC Educational Resources Information Center

Gambini, Barbara

2006-01-01

Despite the great progress in increasing public awareness of and attention to the issue of sustainability, the measures taken so far fall dramatically short of halting deleterious cycles. This apparent deficiency can be ascribed to two main factors: insufficient efforts to finding viable and visible alternatives and the failure to thoroughly…

Distributed Energy Resources and Dynamic Microgrid: An Integrated Assessment

NASA Astrophysics Data System (ADS)

Shang, Duo Rick

The overall goal of this thesis is to improve understanding in terms of the benefit of DERs to both utility and to electricity end-users when integrated in power distribution system. To achieve this goal, a series of two studies was conducted to assess the value of DERs when integrated with new power paradigms. First, the arbitrage value of DERs was examined in markets with time-variant electricity pricing rates (e.g., time of use, real time pricing) under a smart grid distribution paradigm. This study uses a stochastic optimization model to estimate the potential profit from electricity price arbitrage over a five-year period. The optimization process involves two types of PHEVs (PHEV-10, and PHEV-40) under three scenarios with different assumptions on technology performance, electricity market and PHEV owner types. The simulation results indicate that expected arbitrage profit is not a viable option to engage PHEVs in dispatching and in providing ancillary services without more favorable policy and PHEV battery technologies. Subsidy or change in electricity tariff or both are needed. Second, it examined the concept of dynamic microgrid as a measure to improve distribution resilience, and estimates the prices of this emerging service. An economic load dispatch (ELD) model is developed to estimate the market-clearing price in a hypothetical community with single bid auction electricity market. The results show that the electricity market clearing price on the dynamic microgrid is predominantly decided by power output and cost of electricity of each type of DGs. At circumstances where CHP is the only source, the electricity market clearing price in the island is even cheaper than the on-grid electricity price at normal times. Integration of PHEVs in the dynamic microgrid will increase electricity market clearing prices. It demonstrates that dynamic microgrid is an economically viable alternative to enhance grid resilience.

Overview of NASA Electrified Aircraft Propulsion Research for Large Subsonic Transports

NASA Technical Reports Server (NTRS)

Jansen, Ralph H.; Bowman, Cheryl; Jankovsky, Amy; Dyson, Rodger; Felder, James L.

2017-01-01

NASA is investing in Electrified Aircraft Propulsion (EAP) research as part of the portfolio to improve the fuel efficiency, emissions, and noise levels in commercial transport aircraft. Turboelectric, partially turboelectric, and hybrid electric propulsion systems are the primary EAP configurations being evaluated for regional jet and larger aircraft. The goal is to show that one or more viable EAP concepts exist for narrow body aircraft and mature tall-pole technologies related to those concepts. A summary of the aircraft system studies, technology development, and facility development is provided. The leading concept for mid-term (2035) introduction of EAP for a single aisle aircraft is a tube and wing, partially turbo electric configuration (STARC-ABL), however other viable configurations exist. Investments are being made to raise the TRL (Technology Readiness Level) level of light weight, high efficiency motors, generators, and electrical power distribution systems as well as to define the optimal turbine and boundary layer ingestion systems for a mid-term tube and wing configuration. An electric aircraft power system test facility (NEAT - NASA’s Electric Aircraft Testbed) is under construction at NASA Glenn and an electric aircraft control system test facility (HEIST - Hybrid-Electric Integrated Systems Testbed) is under construction at NASA Armstrong. The correct building blocks are in place to have a viable, large plane EAP configuration tested by 2025 leading to entry into service in 2035 if the community chooses to pursue that goal.

ENGINEERING STUDY FOR THE 200 AREA EFFLUENT TREATMENT FACILITY (ETF) SECONDARY WASTE TREATMENT OF PROJECTED FUTURE WASTE FEEDS

DOE Office of Scientific and Technical Information (OSTI.GOV)

LUECK, K.J.

2004-10-18

This report documents an engineering study conducted to evaluate alternatives for treating secondary waste in the secondary treatment train (STT) of the Hanford Site 200 Area Effluent Treatment Facility (ETF). The study evaluates ETF STT treatment alternatives and recommends preferred alternatives for meeting the projected future missions of the ETF. The preferred alternative(s) will process projected future ETF influents to produce a solid waste acceptable for final disposal on the Hanford Site. The main text of this report summarizes the ETF past and projected operations, lists the assumptions about projected operations that provide the basis for the engineering evaluation, andmore » summarizes the evaluation process. The evaluation process includes identification of available modifications to the current ETF process, screens those modifications for technical viability, evaluates the technically viable alternatives, and provides conclusions and recommendations based on that evaluation.« less

Overcoming Barriers To IVHS -- Lessons From Other Technologies, Final Task F Report, Model Advanced Traffic Management System Franchise Agreement

DOT National Transportation Integrated Search

1995-08-25

VIABLE ADVANCED TRAFFIC MANAGEMENT SYSTEMS WILL BE CENTRAL TO THE : DEVELOPMENT OF ITS TECHNOLOGIES, AND CRITICAL TO THE DELIVERY OF MANY PRIVATE SECTOR ITS SERVICES TO THE PUBLIC. BY ITS VERY NATURE, HOWEVER, ATMS RELIES HEAVILY ON ACCESS TO THE PUB...

Identification of an Immobilization Technology for Per- and Polyfluoroalkyl Substances (PFAS) Contamination in Soil and Sediment

EPA Science Inventory

Technologies for PFAS remediation in soil are in their infancy stage, with excavation and disposal in landfills the only currently viable option at many sites in the U.S. PFAS remediation is challenging since some compounds are resistant to destruction or degradation. The overal...

40 CFR 35.908 - Innovative and alternative technologies.

Code of Federal Regulations, 2011 CFR

2011-07-01

... 40 Protection of Environment 1 2011-07-01 2011-07-01 false Innovative and alternative technologies... § 35.908 Innovative and alternative technologies. (a) Policy. EPA's policy is to encourage and, where possible, to assist in the development of innovative and alternative technologies for the construction of...

40 CFR 35.908 - Innovative and alternative technologies.

Code of Federal Regulations, 2013 CFR

2013-07-01

... 40 Protection of Environment 1 2013-07-01 2013-07-01 false Innovative and alternative technologies... § 35.908 Innovative and alternative technologies. (a) Policy. EPA's policy is to encourage and, where possible, to assist in the development of innovative and alternative technologies for the construction of...

40 CFR 35.908 - Innovative and alternative technologies.

Code of Federal Regulations, 2012 CFR

2012-07-01

... 40 Protection of Environment 1 2012-07-01 2012-07-01 false Innovative and alternative technologies... § 35.908 Innovative and alternative technologies. (a) Policy. EPA's policy is to encourage and, where possible, to assist in the development of innovative and alternative technologies for the construction of...

40 CFR 35.908 - Innovative and alternative technologies.

Code of Federal Regulations, 2014 CFR

2014-07-01

... 40 Protection of Environment 1 2014-07-01 2014-07-01 false Innovative and alternative technologies... § 35.908 Innovative and alternative technologies. (a) Policy. EPA's policy is to encourage and, where possible, to assist in the development of innovative and alternative technologies for the construction of...

40 CFR 35.908 - Innovative and alternative technologies.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 40 Protection of Environment 1 2010-07-01 2010-07-01 false Innovative and alternative technologies... § 35.908 Innovative and alternative technologies. (a) Policy. EPA's policy is to encourage and, where possible, to assist in the development of innovative and alternative technologies for the construction of...

Full-Field Strain Methods for Investigating Failure Mechanisms in Triaxial Braided Composites

NASA Technical Reports Server (NTRS)

Littell, Justin D.; Binienda, Wieslaw K.; Goldberg, Robert K.; Roberts, Gary D.

2008-01-01

Recent advancements in braiding technology have led to commercially viable manufacturing approaches for making large structures with complex shape out of triaxial braided composite materials. In some cases, the static load capability of structures made using these materials has been higher than expected based on material strength properties measured using standard coupon tests. A more detailed investigation of deformation and failure processes in large-unit-cell-size triaxial braid composites is needed to evaluate the applicability of standard test methods for these materials and to develop alternative testing approaches. This report presents some new techniques that have been developed to investigate local deformation and failure using digital image correlation techniques. The methods were used to measure both local and global strains during standard straight-sided coupon tensile tests on composite materials made with 12- and 24-k yarns and a 0 /+60 /-60 triaxial braid architecture. Local deformation and failure within fiber bundles was observed and correlations were made between these local failures and global composite deformation and strength.

Virus induced gene silencing (VIGS) for functional analysis of wheat genes involved in Zymoseptoria tritici susceptibility and resistance.

PubMed

Lee, Wing-Sham; Rudd, Jason J; Kanyuka, Kostya

2015-06-01

Virus-induced gene silencing (VIGS) has emerged as a powerful reverse genetic technology in plants supplementary to stable transgenic RNAi and, in certain species, as a viable alternative approach for gene functional analysis. The RNA virus Barley stripe mosaic virus (BSMV) was developed as a VIGS vector in the early 2000s and since then it has been used to study the function of wheat genes. Several variants of BSMV vectors are available, with some requiring in vitro transcription of infectious viral RNA, while others rely on in planta production of viral RNA from DNA-based vectors delivered to plant cells either by particle bombardment or Agrobacterium tumefaciens. We adapted the latest generation of binary BSMV VIGS vectors for the identification and study of wheat genes of interest involved in interactions with Zymoseptoria tritici and here present detailed and the most up-to-date protocols. Copyright © 2015 The Authors. Published by Elsevier Inc. All rights reserved.

Small unmanned aircraft systems for remote sensing and Earth science research

NASA Astrophysics Data System (ADS)

Hugenholtz, Chris H.; Moorman, Brian J.; Riddell, Kevin; Whitehead, Ken

2012-06-01

To understand and predict Earth-surface dynamics, scientists often rely on access to the latest remote sensing data. Over the past several decades, considerable progress has been made in the development of specialized Earth observation sensors for measuring a wide range of processes and features. Comparatively little progress has been made, however, in the development of new platforms upon which these sensors can be deployed. Conventional platforms are still almost exclusively restricted to piloted aircraft and satellites. For many Earth science research questions and applications these platforms do not yet have the resolution or operational flexibility to provide answers affordably. The most effective remote sensing data match the spatiotemporal scale of the process or feature of interest. An emerging technology comprising unmanned aircraft systems (UAS), also known as unmanned aerial vehicles (UAV), is poised to offer a viable alternative to conventional platforms for acquiring high-resolution remote sensing data with increased operational flexibility, lower cost, and greater versatility (Figure 1).

Human Mars Transportation Applications Using Solar Electric Propulsion

NASA Technical Reports Server (NTRS)

Donahue, Benjamin B.; Martin, Jim; Potter, Seth; Henley, Mark; Carrington, Connie (Technical Monitor)

2000-01-01

Advanced solar electric power systems and electric propulsion technology constitute viable elements for conducting human Mars transfer missions that are roughly comparable in performance to similar missions utilizing alternative high thrust systems, with the one exception being their inability to achieve short Earth-Mars trip times. A modest solar electric propulsion human Mars scenario is presented that features the use of conjunction class trajectories in concert with pre-emplacement of surface assets that can be used in a series of visits to Mars. Major elements of the Mars solar electric transfer vehicle can be direct derivatives of present state-of-the-art Solar array and electric thruster systems. During the study, several elements affecting system performance were evaluated, including varying Earth orbit altitude for departure, recapturing the transfer stage at Earth for reuse, varying power system mass-to-power ratio, and assessing solar array degradation on performance induced by Van Allen belt passage. Comparisons are made to chemical propulsion and nuclear thermal propulsion Mars vehicles carrying similar payloads.

Scientific Habits of Mind in Virtual Worlds

NASA Astrophysics Data System (ADS)

Steinkuehler, Constance; Duncan, Sean

2008-12-01

In today's increasingly "flat" world of globalization (Friedman 2005), the need for a scientifically literate citizenry has grown more urgent. Yet, by some measures, we have done a poor job at fostering scientific habits of mind in schools. Recent research on informal games-based learning indicates that such technologies and the communities they evoke may be one viable alternative—not as a substitute for teachers and classrooms, but as an alternative to textbooks and science labs. This paper presents empirical evidence about the potential of games for fostering scientific habits of mind. In particular, we examine the scientific habits of mind and dispositions that characterize online discussion forums of the massively multiplayer online game World of Warcraft. Eighty-six percent of the forum discussions were posts engaged in "social knowledge construction" rather than social banter. Over half of the posts evidenced systems based reasoning, one in ten evidenced model-based reasoning, and 65% displayed an evaluative epistemology in which knowledge is treated as an open-ended process of evaluation and argument.

Beyond ketonization: selective conversion of carboxylic acids to olefins over balanced Lewis acid–base pairs

DOE Office of Scientific and Technical Information (OSTI.GOV)

Baylon, Rebecca A. L.; Sun, Junming; Martin, Kevin J.

Dwindling petroleum reserves combined with increased energy demand and political factors encouraging an increase in energy independence have led to a large amount of research on sustainable alternatives. To this end, biomass conversion has been recognized as themost readily viable technology to produce biofuel concerning our reliance on liquid fuels for transportation and has the advantage of being easily integrated into our heavy use of combustion engines. The interest in biomass conversion has also resulted in reduced costs and a greater abundance of bio-oil, a mixture of hundreds of oxygenates including alcohols, aldehydes, carboxylic acids, and ketones. However, the presencemore » of carboxylic acids in bio-oil derived from lignocellulose pyrolysis leads to low pH, instability, and corrosiveness. In addition, carboxylic acids (i.e. acetic acid) can also be produced via fermentation of sugars. This can be accomplished by a variety of homoacetogenic microorganisms that can produce acetic acid with 100% carbon yield.« less

Composite prognostic models across the non-alcoholic fatty liver disease spectrum: Clinical application in developing countries

PubMed Central

Lückhoff, Hilmar K; Kruger, Frederik C; Kotze, Maritha J

2015-01-01

Heterogeneity in clinical presentation, histological severity, prognosis and therapeutic outcomes characteristic of non-alcoholic fatty liver disease (NAFLD) necessitates the development of scientifically sound classification schemes to assist clinicians in stratifying patients into meaningful prognostic subgroups. The need for replacement of invasive liver biopsies as the standard method whereby NAFLD is diagnosed, graded and staged with biomarkers of histological severity injury led to the development of composite prognostic models as potentially viable surrogate alternatives. In the present article, we review existing scoring systems used to (1) confirm the presence of undiagnosed hepatosteatosis; (2) distinguish between simple steatosis and NASH; and (3) predict advanced hepatic fibrosis, with particular emphasis on the role of NAFLD as an independent cardio-metabolic risk factor. In addition, the incorporation of functional genomic markers and application of emerging imaging technologies are discussed as a means to improve the diagnostic accuracy and predictive performance of promising composite models found to be most appropriate for widespread clinical adoption. PMID:26019735

Automation life-cycle cost model

NASA Technical Reports Server (NTRS)

Gathmann, Thomas P.; Reeves, Arlinda J.; Cline, Rick; Henrion, Max; Ruokangas, Corinne

1992-01-01

The problem domain being addressed by this contractual effort can be summarized by the following list: Automation and Robotics (A&R) technologies appear to be viable alternatives to current, manual operations; Life-cycle cost models are typically judged with suspicion due to implicit assumptions and little associated documentation; and Uncertainty is a reality for increasingly complex problems and few models explicitly account for its affect on the solution space. The objectives for this effort range from the near-term (1-2 years) to far-term (3-5 years). In the near-term, the envisioned capabilities of the modeling tool are annotated. In addition, a framework is defined and developed in the Decision Modelling System (DEMOS) environment. Our approach is summarized as follows: Assess desirable capabilities (structure into near- and far-term); Identify useful existing models/data; Identify parameters for utility analysis; Define tool framework; Encode scenario thread for model validation; and Provide transition path for tool development. This report contains all relevant, technical progress made on this contractual effort.

A fusion of minicircle DNA and nanoparticle delivery technologies facilitates therapeutic genetic engineering of autologous canine olfactory mucosal cells.

PubMed

Delaney, Alexander M; Adams, Christopher F; Fernandes, Alinda R; Al-Shakli, Arwa F; Sen, Jon; Carwardine, Darren R; Granger, Nicolas; Chari, Divya M

2017-06-29

Olfactory ensheathing cells (OECs) promote axonal regeneration and improve locomotor function when transplanted into the injured spinal cord. A recent clinical trial demonstrated improved motor function in domestic dogs with spinal injury following autologous OEC transplantation. Their utility in canines offers promise for human translation, as dogs are comparable to humans in terms of clinical management and genetic/environmental variation. Moreover, the autologous, minimally invasive derivation of OECs makes them viable for human spinal injury investigation. Genetic engineering of transplant populations may augment their therapeutic potential, but relies heavily on viral methods which have several drawbacks for clinical translation. We present here the first proof that magnetic particles deployed with applied magnetic fields and advanced DNA minicircle vectors can safely bioengineer OECs to secrete a key neurotrophic factor, with an efficiency approaching that of viral vectors. We suggest that our alternative approach offers high translational potential for the delivery of augmented clinical cell therapies.

Scattering Studies on Poly(3,4-ethylenedioxythiophene)- Polystyrenesulfonate in the Presence of Ionic Liquids

DOE PAGES

Murphy, Ryan J.; Weigandt, Katie M.; Uhrig, David; ...

2015-11-30

The demand for lower cost and flexible electronics has driven industry to develop alternative transparent electrode (TE) materials to replace indium tin oxide (ITO). ITO is the benchmark TE on the market, but its high cost and low flexibility limit it for use in future technologies. Recent work has shown the combination of the conducting polymer poly(3,4-ethylenedioxythiophene)–polystyrenesulfonate (PEDOT:PSS) with the ionic liquid 1-ethyl-3-methylimidazolium tetracyanoborate (EMIM:TCB) is a viable ITO replacement. This study investigates the nature of the interaction between PEDOT:PSS and EMIM:TCB in the solution state. A combination of scattering methods is used to illustrate a novel, multilength scale modelmore » of this system. At length scales larger than 300nm PEODT:PSS adopts a microgel-like structure, and below ~300nm the system adopts an entangled polyelectrolyte mesh structure. As EMIM:TCB is added, the microgel interior adopts a more neutral polymer mesh structure as EMIM:TCB concentration is increased.« less

Carbon recovery by fermentation of CO-rich off gases - Turning steel mills into biorefineries.

PubMed

Molitor, Bastian; Richter, Hanno; Martin, Michael E; Jensen, Rasmus O; Juminaga, Alex; Mihalcea, Christophe; Angenent, Largus T

2016-09-01

Technological solutions to reduce greenhouse gas (GHG) emissions from anthropogenic sources are required. Heavy industrial processes, such as steel making, contribute considerably to GHG emissions. Fermentation of carbon monoxide (CO)-rich off gases with wild-type acetogenic bacteria can be used to produce ethanol, acetate, and 2,3-butanediol, thereby, reducing the carbon footprint of heavy industries. Here, the processes for the production of ethanol from CO-rich off gases are discussed and a perspective on further routes towards an integrated biorefinery at a steel mill is given. Recent achievements in genetic engineering as well as integration of other biotechnology platforms to increase the product portfolio are summarized. Already, yields have been increased and the portfolio of products broadened. To develop a commercially viable process, however, the extraction from dilute product streams is a critical step and alternatives to distillation are discussed. Finally, another critical step is waste(water) treatment with the possibility to recover resources. Copyright © 2016 Elsevier Ltd. All rights reserved.

Design, fabrication and delivery of a miniature Cassegrainian concentrator solar array system

NASA Technical Reports Server (NTRS)

Kruer, Mark A.

1987-01-01

The optical design of the miniature Cassegrainian concentrator (MCC) element was improved for both offpoint and onpoint power capability. The cell stack design has shown no losses under the high short term thermal stresses imposed by component level test and is projected to be capable of greater than five years thermal cycle life in low Earth orbit. The structural design met all requirements for stiffness and flatness and requires adjustable inserts for fine tuning of the GFRP structure to meet flatness goals. The completed, fully populated small and large MCC panels deliverable under this contract perform electrically as expected. A solid acceptance inspection program to guarantee quality of all purchased parts, and continued manufacturing process improvements will make the MCC design a viable low cost alternative to standard flat panel technology. Minor improvements to the cell stack design of the MCC element can make significant improvements in both the performance and manufacturability of the MCC system.

Physics First: Impact on SAT Math Scores

NASA Astrophysics Data System (ADS)

Bouma, Craig E.

Improving science, technology, engineering, and mathematics (STEM) education has become a national priority and the call to modernize secondary science has been heard. A Physics First (PF) program with the curriculum sequence of physics, chemistry, and biology (PCB) driven by inquiry- and project-based learning offers a viable alternative to the traditional curricular sequence (BCP) and methods of teaching, but requires more empirical evidence. This study determined impact of a PF program (PF-PCB) on math achievement (SAT math scores) after the first two cohorts of students completed the PF-PCB program at Matteo Ricci High School (MRHS) and provided more quantitative data to inform the PF debate and advance secondary science education. Statistical analysis (ANCOVA) determined the influence of covariates and revealed that PF-PCB program had a significant (p < .05) impact on SAT math scores in the second cohort at MRHS. Statistically adjusted, the SAT math means for PF students were 21.4 points higher than their non-PF counterparts when controlling for prior math achievement (HSTP math), socioeconomic status (SES), and ethnicity/race.

Use of Computed Tomography for Characterizing Materials Grown Terrestrially and in Microgravity

NASA Technical Reports Server (NTRS)

Gillies, Donald C.; Engel, H. P.

2001-01-01

The purpose behind this work is to provide NASA Principal Investigators (PIs) rapid information, nondestructively, about their samples. This information will be in the form of density values throughout the samples, especially within slices 1 mm high. With correct interpretation and good calibration, these values will enable the PI to obtain macro chemical compositional analysis for his/her samples. Alternatively, the technique will provide information about the porosity level and its distribution within the sample. Experience gained with a NASA Microgravity Research Division-sponsored Advanced Technology Development (ATD) project on this topic has brought the technique to a level of maturity at which it has become a viable characterization tool for many of the Materials Science Pls, but with equipment that could never be supported within their own facilities. The existing computed tomography (CT) facility at NASA's Kennedy Space Center (KSC) is ideally situated to furnish information rapidly and conveniently to PIs, particularly immediately before and after flight missions.

Use of Computed Tomography for Characterizing Materials Grown Terrestrially and in Microgravity

NASA Technical Reports Server (NTRS)

Gillies, Donald C.; Engel, H. P.

2000-01-01

The purpose behind this work is to provide NASA Principal Investigators (PI) rapid information, non-destructively, about their samples. This information will be in the form of density values throughout the samples, especially within slices 1 mm high. With correct interpretation and good calibration, these values will enable the PI to obtain macro chemical compositional analysis for his/her samples. Alternatively, the technique will provide information about the porosity level and its distribution within the sample. Experience gained with a NASA MRD-sponsored Advanced Technology Development (ATD) project on this topic has brought the technique to a level of maturity at which it has become a viable characterization tool for many of the Materials Science PIs, but with equipment that could never be supported within their own facilities. The existing computed tomography (CT) facility at NASA's Kennedy Space Center (KSC) is ideally situated to furnish information rapidly and conveniently to PIs, particularly immediately before and after flight missions.

A comparison of Frequency Domain Multiple Access (FDMA) and Time Domain Multiple Access (TDMA) approaches to satellite service for low data rate Earth stations

NASA Technical Reports Server (NTRS)

Stevens, G.

1983-01-01

A technological and economic assessment is made of providing low data rate service to small earth stations by satellite at Ka-band. Various Frequency Domain Multiple Access (FDMA) and Time Domain Multiple Access (TDMA) scenarios are examined and compared on the basis of cost to the end user. Very small stations (1 to 2 meters in diameter) are found not to be viable alternatives to available terrestrial services. However, medium size (3 to 5 meters) earth stations appear to be very competitive if a minimum throughput of about 1.5 Mbs is maintained. This constrains the use of such terminals to large users and shared use by smaller users. No advantage was found to the use of FDMA. TDMA had a slight advantage from a total system viewpoint and a very significant advantage in the space segment (about 1/3 the required payload weight for an equivalent capacity).

In vitro evaluation of dietary compounds to reduce mercury bioavailability.

PubMed

Jadán-Piedra, Carlos; Vélez, Dinoraz; Devesa, Vicenta

2018-05-15

Mercury in foods, in inorganic form [Hg(II)] or as methylmercury (CH 3 Hg), can have adverse effects. Its elimination from foods is not technologically viable. To reduce human exposure, possible alternatives might be based on reducing its intestinal absorption. This study evaluates the ability of 23 dietary components to reduce the amount of mercury that is absorbed and reaches the bloodstream (bioavailability). We determined their effect on uptake of mercury in Caco-2 cells, a model of intestinal epithelium, exposed to Hg(II) and CH 3 Hg standards and to swordfish bioaccessible fractions. Cysteine, homocysteine, glutathione, quercetin, albumin and tannic reduce bioavailability of both mercury species. Fe(II), lipoic acid, pectin, epigallocatechin and thiamine are also effective for Hg(II). Some of these strategies also reduce Hg bioavailability in swordfish (glutathione, cysteine, homocysteine). Moreover, extracts and supplements rich in these compounds are also effective. This knowledge may help to define dietary strategies to reduce in vivo mercury bioavailability. Copyright © 2017 Elsevier Ltd. All rights reserved.

An assessment of a collaborative mapping approach for exploring land use patterns for several European metropolises

NASA Astrophysics Data System (ADS)

Jokar Arsanjani, Jamal; Vaz, Eric

2015-03-01

Until recently, land surveys and digital interpretation of remotely sensed imagery have been used to generate land use inventories. These techniques however, are often cumbersome and costly, allocating large amounts of technical and temporal costs. The technological advances of web 2.0 have brought a wide array of technological achievements, stimulating the participatory role in collaborative and crowd sourced mapping products. This has been fostered by GPS-enabled devices, and accessible tools that enable visual interpretation of high resolution satellite images/air photos provided in collaborative mapping projects. Such technologies offer an integrative approach to geography by means of promoting public participation and allowing accurate assessment and classification of land use as well as geographical features. OpenStreetMap (OSM) has supported the evolution of such techniques, contributing to the existence of a large inventory of spatial land use information. This paper explores the introduction of this novel participatory phenomenon for land use classification in Europe's metropolitan regions. We adopt a positivistic approach to assess comparatively the accuracy of these contributions of OSM for land use classifications in seven large European metropolitan regions. Thematic accuracy and degree of completeness of OSM data was compared to available Global Monitoring for Environment and Security Urban Atlas (GMESUA) datasets for the chosen metropolises. We further extend our findings of land use within a novel framework for geography, justifying that volunteered geographic information (VGI) sources are of great benefit for land use mapping depending on location and degree of VGI dynamism and offer a great alternative to traditional mapping techniques for metropolitan regions throughout Europe. Evaluation of several land use types at the local level suggests that a number of OSM classes (such as anthropogenic land use, agricultural and some natural environment classes) are viable alternatives for land use classification. These classes are highly accurate and can be integrated into planning decisions for stakeholders and policymakers.

Composite Artistry Meets Facial Recognition Technology: Exploring the Use of Facial Recognition Technology to Identify Composite Images

DTIC Science & Technology

2011-09-01

be submitted into a facial recognition program for comparison with millions of possible matches, offering abundant opportunities to identify the...to leverage the robust number of comparative opportunities associated with facial recognition programs. This research investigates the efficacy of...combining composite forensic artistry with facial recognition technology to create a viable investigative tool to identify suspects, as well as better

Is self-sufficiency financially viable and ethically justifiable?--a commercial viewpoint.

PubMed

Christie, R B

1994-12-01

Manufacturers of blood products have to maintain the highest possible standards for plasma screening and good manufacturing practices to ensure maximum purity and viral safety. The private sector companies have much experience in implementing and complying with national and international regulations. These requirements involve considerable cost in the areas of (1) plasma collection facilities, (2) research and clinical research, (3) manufacture, and (4) quality control. Total self-sufficiency would mean the loss of many existing resources. An alternative would be a collaboration between the public and private sectors to meet the needs of all patients who require plasma derived products. The current definition of self-sufficiency suggests that it is not financially viable.

LED roadway luminaires evaluation.

DOT National Transportation Integrated Search

2011-12-01

This research explores whether LEDroadway luminaire technologies are a viable future solution to providing roadway lighting. Roadway lighting enhances highway safety and traffic flow during limited lighting conditions. The purpose of this evaluation ...

Learning through a portfolio of carbon capture and storage demonstration projects

NASA Astrophysics Data System (ADS)

Reiner, David M.

2016-01-01

Carbon dioxide capture and storage (CCS) technology is considered by many to be an essential route to meet climate mitigation targets in the power and industrial sectors. Deploying CCS technologies globally will first require a portfolio of large-scale demonstration projects. These first projects should assist learning by diversity, learning by replication, de-risking the technologies and developing viable business models. From 2005 to 2009, optimism about the pace of CCS rollout led to mutually independent efforts in the European Union, North America and Australia to assemble portfolios of projects. Since 2009, only a few of these many project proposals remain viable, but the initial rationales for demonstration have not been revisited in the face of changing circumstances. Here I argue that learning is now both more difficult and more important given the slow pace of deployment. Developing a more coordinated global portfolio will facilitate learning across projects and may determine whether CCS ever emerges from the demonstration phase.

Space Transportation Avionics Technology Symposium. Volume 1: Executive summary

NASA Technical Reports Server (NTRS)

1990-01-01

The focus of the symposium was to examine existing and planned avionics technology processes and products and to recommend necessary changes for strengthening priorities and program emphases. Innovative changes in avionics technology development and design processes, identified during the symposium, are needed to support the increasingly complex, multi-vehicle, integrated, autonomous space-based systems. Key technology advances make such a major initiative viable at this time: digital processing capabilities, integrated on-board test/checkout methods, easily reconfigurable laboratories, and software design and production techniques.

Space Transportation Avionics Technology Symposium. Volume 2: Conference Proceedings

NASA Technical Reports Server (NTRS)

1990-01-01

The focus of the symposium was to examine existing and planned avionics technology processes and products and to recommend necessary changes for strengthening priorities and program emphases. Innovative changes in avionics technology development and design processes are needed to support the increasingly complex, multi-vehicle, integrated, autonomous space-based systems. Key technology advances make such a major initiative viable at this time: digital processing capabilities, integrated on-board test/checkout methods, easily reconfigurable laboratories, and software design and production techniques.

Parametric evaluation of the cost effectiveness of Shuttle payload vibroacoustic test plans

NASA Technical Reports Server (NTRS)

Stahle, C. V.; Gongloff, H. R.; Keegan, W. B.; Young, J. P.

1978-01-01

Consideration is given to alternate vibroacoustic test plans for sortie and free flyer Shuttle payloads. Statistical decision models for nine test plans provide a viable method of evaluating the cost effectiveness of alternate vibroacoustic test plans and the associated test levels. The methodology is a major step toward the development of a useful tool for the quantitative tailoring of vibroacoustic test programs to sortie and free flyer payloads. A broader application of the methodology is now possible by the use of the OCTAVE computer code.

Laser power conversion system analysis, volume 2

NASA Technical Reports Server (NTRS)

Jones, W. S.; Morgan, L. L.; Forsyth, J. B.; Skratt, J. P.

1979-01-01

The orbit-to-ground laser power conversion system analysis investigated the feasibility and cost effectiveness of converting solar energy into laser energy in space, and transmitting the laser energy to earth for conversion to electrical energy. The analysis included space laser systems with electrical outputs on the ground ranging from 100 to 10,000 MW. The space laser power system was shown to be feasible and a viable alternate to the microwave solar power satellite. The narrow laser beam provides many options and alternatives not attainable with a microwave beam.

Low Intensity Low Temperature (LILT) measurements and coefficients on new photovoltaic structures

NASA Technical Reports Server (NTRS)

Schelman, David A.; Jenkins, Philip P.; Brinker, David J.; Appelbaum, Joseph

1995-01-01

Past NASA missions to Mars, Jupiter, and the outer planets were powered by radioisotope thermal generators (RTG's). Although these devices proved to be reliable, their high cost and highly toxic radioactive heat source has made them far less desirable for future planetary missions. This has resulted in a renewed search for alternate energy sources, some of them being photovoltaic (PV) and thermophotovoltaic (TPV). Both of these alternate energy sources convert light/thermal energy directly into electricity. In order to create a viable PV and TPV data base for planetary mission planners and cell designers, we have compiled low temperature low intensity (LILT) I-V data on single junction and multi-junction high efficiency solar cells. The cells tested here represent the latest photovoltaic technology. Using this LILT data to calculate dI(sub SC)/dT, dV(sub OC)/dT, dFF/dT, and also as a function of intensity, an accurate prediction of cell performance under the AMO spectrum can be determined. When combined with QUantum efficiency at Low Temperature (QULT) data, one can further enhance the data by adding spectral variations to the measurements. This paper presents an overview of LILT measurements and is only intended to be used as a guideline for material selection and performance predictions. As single junction and multi-junction cell technologies emerge, new test data must be collected. Cell materials included are Si, GaAs/Ge, GainP/GaAs/Ge, InP, InGaAs/InP, InP/InGaAs/InP, and GainP. Temperatures range as low as -175 C and intensities range from 1 sun to .02 suns.

Low Intensity Low Temperature (LILT) Measurements and Coefficients on New Photovoltaic Structures

NASA Technical Reports Server (NTRS)

Scheiman, David A.; Jenkins, Phillip P.; Brinker, David J.; Appelbaum, Joseph

1995-01-01

Past NASA missions to Mars, Jupiter and the outer planets were powered by radioisotope thermal generators (RTGs). Although these devices proved to be reliable, their high cost and highly toxic radioactive heat source has made them far less desirable for future planetary missions. This has resulted in a renewed search for alternate energy sources, some of them being photovoltaics (PV) and thermophotovoltaics (TPV). Both of these alternate energy sources convert light/thermal energy directly into electricity. In order to create a viable PV data base for planetary mission planners and cell designers, we have compiled low intensity low temperature (LILT) I-V data on single junction and multi-junction high efficiency solar cells. The cells tested here represent the latest photovoltaic technology. Using this LILT data to calculate Short Circuit Current (I(sub sc)), Open Circuit Voltage (V(sub os)), and Fill Factor (FF) as a function of temperature and intensity, an accurate prediction of cell performance under the AM0 spectrum can be determined. When combined with QUantum efficiency at Low Temperature (QULT) data, one can further enhance the data by adding spectral variations to the measurements. This paper presents an overview of LILT measurements and is only intended to be used as a guideline for material selection and performance predictions. As single junction and multi-junction cell technologies emerge, new test data must be collected. Cell materials included are Si, GaAs/Ge, GaInP/GaAs/GaAs, InP, InGaAs/InP, InP/InGaAs/InP, and GaInP. Temperatures range down to as low as -180 C and intensities range from 1 sun down to 0.02 suns. The coefficients presented in this paper represent experimental results and are intended to provide the user with approximate numbers.

Electrostatic artificial eyelid actuator as an analog micromirror device

NASA Astrophysics Data System (ADS)

Goodwin, Scott H.; Dausch, David E.; Solomon, Steven L.; Lamvik, Michael K.

2005-05-01

An electrostatic MEMS actuator is described for use as an analog micromirror device (AMD) for high performance, broadband, hardware-in-the-loop (HWIL) scene generation. Current state-of-the-art technology is based on resistively heated pixel arrays. As these arrays drive to the higher scene temperatures required by missile defense scenarios, the power required to drive the large format resistive arrays will ultimately become prohibitive. Existing digital micromirrors (DMD) are, in principle, capable of generating the required scene irradiances, but suffer from limited dynamic range, resolution and flicker effects. An AMD would be free of these limitations, and so represents a viable alternative for high performance UV/VIS/IR scene generation. An electrostatic flexible film actuator technology, developed for use as "artificial eyelid" shutters for focal plane sensors to protect against damaging radiation, is suitable as an AMD for analog control of projection irradiance. In shutter applications, the artificial eyelid actuator contained radius of curvature as low as 25um and operated at high voltage (>200V). Recent testing suggests that these devices are capable of analog operation as reflective microcantilever mirrors appropriate for scene projector systems. In this case, the device would possess larger radius and operate at lower voltages (20-50V). Additionally, frame rates have been measured at greater than 5kHz for continuous operation. The paper will describe the artificial eyelid technology, preliminary measurements of analog test pixels, and design aspects related to application for scene projection systems. We believe this technology will enable AMD projectors with at least 5122 spatial resolution, non-temporally-modulated output, and pixel response times of <1.25ms.

The attitudes of science policy, environmental, and utility leaders on US energy issues and fusion

NASA Astrophysics Data System (ADS)

Miller, J. D.

1986-11-01

One example of basic and applied research at LLNL that has produced major, highly visible scientific and engineering advances has been the research related to controlled fusion energy. Continuing experimentation at LLNL and elsewhere is likely to demonstrate that fusion is a viable, inexhaustible alternative source of energy. Having conducted major fusion energy experiments for over 30 years at LLNL, it scientists and engineers recognized the enormous challenges that lay ahead in this important endeavor. To be successful, it was clear that collaborative efforts with universities, private industry, and other national laboratories would need to be greatly expanded. Along with invention and scientific discovery would come the challenge of transferring the myriad of new technologies from the laboratories to the private sector for commercialization of the fusion energy process and the application of related technologies to yet unimagined new industries and products. Therefore, using fusion energy research as the focus, the Laboratory's Technology Transfer Initiatives Program contracted with the Public Opinion Laboratory to conduct a survey designed to promote a better understanding of effective technology transfer. As one of the recognized authorities on scientific surveys, Dr. Jon Miller of the POL worked with Laboratory scientists to understand the objectives of the survey. He then formulated the questions, designed the survey, and derived his survey sample from a qualified list developed at the POL, which has formed the basis for other survey panels. This report, prepared by Dr. Miller, describes the basis and methodology of this survey process and then presents the survey findings and some conclusions.

The Most Economic, Socially Viable, and Environmentally Sustainable Alternative Energy

ERIC Educational Resources Information Center

Vanderburg, Willem H.

2008-01-01

The strengths and weaknesses of current energy planning can be attributed to the limited economic, social, and environmental contexts taken into account as a result of the current intellectual and professional division of labor. A preventive approach is developed by which the ratio of desired to undesired effects can be substantially improved. It…

A Short-Term, Intensive Workshop Approach for the Treatment of Human Sexual Inadequacy

ERIC Educational Resources Information Center

Blakeney, Patricia; And Others

1976-01-01

A rapid treatment approach to common sexual dysfunctions has been used in treating 59 couples, including 74 symptomatic individuals. The intensive workshop format resulted in a saving of patient and professional time and is seen as a viable alternative to more time-consuming approaches of treating various sexual dysfunctions. (Author)

MOLASSES AS THE PRIMARY ENERGY SUPPLEMENT ON AN ORGANIC GRAZING DAIRY FARM

USDA-ARS?s Scientific Manuscript database

Organic dairies in New York face challenges, including the high cost of purchasing organic feed grains. Many of these farms are looking for alternative ingredients to use that can be reasonably fed to lactating dairy cows, and that are less costly. Molasses seems to be a viable, less expensive, so...

Comparison as an Approach to the Experimental Method

ERIC Educational Resources Information Center

Turner, David A.

2017-01-01

In his proposal for comparative education, Marc Antoinne Jullien de Paris argues that the comparative method offers a viable alternative to the experimental method. In an experiment, the scientist can manipulate the variables in such a way that he or she can see any possible combination of variables at will. In comparative education, or in…

Podcasting 101 for K-12 Librarians

ERIC Educational Resources Information Center

Eash, Esther Kreider

2006-01-01

Podcast is a digital recording of a radio broadcast or similar program made available on the Internet for downloading to a personal audio player. In other words, it's a digital audio file that is created, shared, and heard. The podcast is a viable alternative for delivering research content or lessons to students who need remedial or extended…

Human research cloning, embryos, and embryo-like artifacts.

PubMed

Hyun, Insoo; Jung, Kyu Won

2006-01-01

Research suggests that cloning is incapable of producing a viable embryo when it is used on primate eggs. In fact, the entity created may not qualify as an embryo at all. If the results stand, cloning avoids the moral objections typically lodged against it, and cloning is itself an "alternative source" of stem cells.

A Review of Models for Computer-Based Testing. Research Report 2011-12

ERIC Educational Resources Information Center

Luecht, Richard M.; Sireci, Stephen G.

2011-01-01

Over the past four decades, there has been incremental growth in computer-based testing (CBT) as a viable alternative to paper-and-pencil testing. However, the transition to CBT is neither easy nor inexpensive. As Drasgow, Luecht, and Bennett (2006) noted, many design engineering, test development, operations/logistics, and psychometric changes…

Is Harm Reduction a Viable Choice for Kids Enchanted with Drugs?

ERIC Educational Resources Information Center

Laursen, Erik K.; Brasler, Paul

2002-01-01

This article describes a strengths-based alternative to substance abuse treatment. Many contemporary youth are experiencing problems with alcohol or other drugs but reject the message of total abstinence and disease models of treatment. The authors draw from their experience and research to combine a strengths perspective with a harm-reduction…

Current Research on Molasses as an Alternative Energy Source for Organic Dairy Herds

USDA-ARS?s Scientific Manuscript database

As organic grain prices have increased and organic milk prices have decreased, dairy farmers are seeking lower-cost supplementation strategies. Sugarcane molasses, a rich source of sucrose, seems to be a viable option as a source of energy. Molasses frequently costs less per pound of dry matter than...

Analysis of parameter sensitivity and identifiability of root zone water quality model (RZWQM) for dryland sugerbeet modeling

USDA-ARS?s Scientific Manuscript database

Sugarbeet is being considered as one of the most viable feedstock alternatives to corn for biofuel production since herbicide resistant energy beets were deregulated by USDA in 2012. Growing sugarbeets for biofuel production may have significant impacts on soil health and water quality in the north-...

An Exploration of Egyptian Students' Attitudes toward Online Learning

ERIC Educational Resources Information Center

El-Zayaty, Nady

2018-01-01

Open and Distance Learning (ODL) has become an increasingly popular platform for delivering education the world over. The acceptance of ODL as a viable alternative to traditional brick and mortar educational institutes has been a topic of debate however. Furthermore, many questions have been raised about the different levels of interest…

NOVEL ASSAY TO ASSESS CYP-2E1-LIKE ACTIVITY IN THE JAPANESE MEDAKA (ORYZIAS LATIPES).

EPA Science Inventory

Liver microsomes and S-9 fraction of Japanese medaka (Oryzias latipes) metabolized the CYP2E1 specific substrate, p-nitrophenol (PNP), to a single hydroxylated product, 4-nitrocatechol. The use of liver S-9 fraction proved to be a viable alternative to liver microsomes and allowe...

Performance Ethnography: Creating a Mechanism for Engagement by the Academy.

ERIC Educational Resources Information Center

Jarmon, Leslie H.

Taking the position that performance ethnography should be a viable and valued alternative and/or supplement to print ethnography, this paper explores ways to integrate phenomena that are visual, aural, and dynamic into existing scholarly practices. The paper advances one solution: create mechanisms for reproduction and distribution that have the…

Effective Practices for Online Delivery of Quantitative Business Courses

ERIC Educational Resources Information Center

Lam, Helen; Khare, Anshuman

2010-01-01

Online delivery of university-level courses has grown exponentially in the last decade and is increasingly being recognised as a viable and effective alternative to face-to-face classroom teaching. Many scholars have already written about the benefits and best practices of online teaching in general. However, not many studies have paid specific…

A Text-Computer Assisted Instruction Program as a Viable Alternative for Continuing Education in Laboratory Medicine.

ERIC Educational Resources Information Center

Bruce, A. Wayne

1986-01-01

Describes reasons for developing combined text and computer assisted instruction (CAI) teaching programs for delivery of continuing education to laboratory professionals, and mechanisms used for developing a CAI program on method evaluation in the clinical laboratory. Results of an evaluation of the software's cost effectiveness and instructional…

A Primer on Logistic Regression.

ERIC Educational Resources Information Center

Woldbeck, Tanya

This paper introduces logistic regression as a viable alternative when the researcher is faced with variables that are not continuous. If one is to use simple regression, the dependent variable must be measured on a continuous scale. In the behavioral sciences, it may not always be appropriate or possible to have a measured dependent variable on a…

43 CFR 404.44 - What criteria will Reclamation apply to determine whether it is appropriate to recommend that a...

Code of Federal Regulations, 2010 CFR

2010-10-01

... THE INTERIOR RECLAMATION RURAL WATER SUPPLY PROGRAM Appraisal Investigations § 404.44 What criteria... in the investigation, whether the alternative: (1) Identifies viable water supplies and water rights sufficient to supply the proposed service area, including all practicable water sources such as lower quality...

Introducing winter canola to the winter wheat-fallow region of the Pacific Northwest

USDA-ARS?s Scientific Manuscript database

Growers in the low-rainfall, winter wheat-fallow region of the Pacific Northwest are in need of an alternative crop to diversify their markets, manage pests, and increase wheat yields. Winter canola may be a viable crop option for growers in the region. However, agronomic research for winter canol...

Designing the Speech Communication Classroom: A Viable Alternative.

ERIC Educational Resources Information Center

Springhorn, Ron G.

This paper presents a structure for the speech communication classroom, based on a philosophically existential approach to education. The following suggestions are offered to those considering such an approach. There should be movable furniture, enabling students to move about and to turn toward one another so that they can be physically in…

Organic Production: Recent Publications and Current Information Sources. Special Reference Briefs: SRB 95-01.

ERIC Educational Resources Information Center

National Agricultural Library, Beltsville, MD.

The activities of the National Organic Standards Board, coupled with the movement towards "sustainable systems" and continued consumer support for organic foods, have made farming organically an increasingly viable alternative for many U.S. farmers. This list of resources is provided to accommodate increasing requests for information on…

Biofuel vs. Biodiversity? Integrated Emergy and Economic Cost-Benefit Evaluation of Rice-Ethanol Production in Japan

EPA Science Inventory

Energy analysis results confirmed that abandoned rice fields provide a good opportunity for Japan to fulfill its E-3 target by producing ethanol from high-yield rice feedstock. However, to be a viable alternative, a biofuel should not only provide a net energy gain and reduce the...

Microform Catalogs: A Viable Alternative for Texas Libraries.

ERIC Educational Resources Information Center

Cox, Carolyn, M.; Juergens, Bonnie

This project proposed to develop and test the use of microform catalogs produced from computer-generated magnetic tape records in both fiche and film formats. The Computer Output Microform (COM) catalog developed for this purpose is a union list of titles from the five participating libraries--Houston and Dallas Public Libraries, Texas State…

Reaching youth through franchise clinics: assessment of Kenyan private sector involvement in youth services.

PubMed

Decker, Martha; Montagu, Dominic

2007-03-01

This paper evaluates the ability of social franchise programs, which use private providers to offer reproductive health services, to provide services to youth in western Kenya. Although franchise clinics have rarely targeted youth, they appear to offer a viable alternative for providing reproductive health services to this age group.

Telepractice: The Australian Experience in an International Context

ERIC Educational Resources Information Center

McCarthy, Melissa; Duncan, Jill; Leigh, Greg

2012-01-01

Telepractice is emerging as a viable alternative to traditional "face-to-face" service as practitioners seek to meet the diverse needs of children who are deaf or hard of hearing and their families. Telepractice provides the opportunity for many countries to expand their reach and viability within their own borders as well as the…

Backtrack Programming: A Computer-Based Approach to Group Problem Solving.

ERIC Educational Resources Information Center

Scott, Michael D.; Bodaken, Edward M.

Backtrack problem-solving appears to be a viable alternative to current problem-solving methodologies. It appears to have considerable heuristic potential as a conceptual and operational framework for small group communication research, as well as functional utility for the student group in the small group class or the management team in the…

The Origin and Significance of the CCAM Line: Evidence from Chondrules and Dark Inclusions in Allende (CV3)

NASA Technical Reports Server (NTRS)

Greenwood, R. C.; Franchi, I. A.; Zolensky, M. E.; Buchanan, P. C.

2016-01-01

The process responsible for the mass independent oxygen isotope variation observed in Solar System materials remains poorly understood. While self-shielding of CO, either in the early solar nebula, or precursor molecular cloud, appears to be a viable mechanism, alternative models have also been proposed.

Careers and Couples: An Academic Question.

ERIC Educational Resources Information Center

Hoffmann, Leonore, Ed.; DeSole, Gloria, Ed.

The 20 articles in this collection concern issues faced by couples in academe. One group of articles considers part-time careers, independent scholarly work, or intermittent employment, which may be viable alternatives for women with families or those who feel less need for a full-time job. The need for institutional policies to support part-time…

Soil disturbance assessment of a cable logging operation performing five silvicultural prescriptions

Treesearch

John Klepac; Steve Reutebuch

2003-01-01

Evaluating alternative methods for regenerating second-growth Douglas-fir (Pseudotsuga menziesii) forests in the Pacific Northwest is an area of interest for resource managers. To meet future demands for timber supply as well as provide stands that are visually acceptable by the public and ecologically viable, a thorough understanding of these...

Managing conflict over biological control: the case of strawberry guava in Hawaii

Treesearch

Tracy Johnson

2016-01-01

Biological control researchers commonly avoid targets with potential for high conflict, but for certain highly damaging invaders with no viable management alternatives, it may be necessary to consider biological control even when it is likely to generate conflict. Discussed here is a case study, strawberry guava (Psidium cattleianum Sabine...

Derivation of sorting programs

NASA Technical Reports Server (NTRS)

Varghese, Joseph; Loganantharaj, Rasiah

1990-01-01

Program synthesis for critical applications has become a viable alternative to program verification. Nested resolution and its extension are used to synthesize a set of sorting programs from their first order logic specifications. A set of sorting programs, such as, naive sort, merge sort, and insertion sort, were successfully synthesized starting from the same set of specifications.

Strengths, Opportunities, Aspirations, and Results: An Emerging Approach to Organization Development

ERIC Educational Resources Information Center

Zarestky, Jill; Cole, Catherine S.

2017-01-01

Organization development (OD) interventions have typically relied on the strengths, weaknesses, opportunities, and threats (SWOT) framework for strategic planning. The strengths, opportunities, aspirations, and results (SOAR) framework is a relatively new innovation in OD that may serve as a viable alternative to SWOT for those who wish to apply…

The Economics of Concern and Compassion: Applications to Rural Justice.

ERIC Educational Resources Information Center

Brown, David W.

The urgent need to correct inequities and shortsighted rural justice practices, i.e., juvenile delinquency problems, makes it crucial that available resources be used wisely and that careful choices be made among the viable alternatives. Twelve basic economic concepts can be helpful in providing a framework or diagnostic perspective that can be…

Soybean Oil: Powering a High School Investigation of Biodiesel

ERIC Educational Resources Information Center

De La Rosa, Paul; Azurin, Katherine A.; Page, Michael F. Z.

2014-01-01

This laboratory investigation challenges students to synthesize, analyze, and compare viable alternative fuels to Diesel No. 2 using a renewable resource, as well as readily available reagents and supplies. During the experiment, students synthesized biodiesel from soybean oil in an average percent yield of 83.8 ± 6.3%. They then prepared fuel…

Cross-Validation of a Short Form of the Marlowe-Crowne Social Desirability Scale.

ERIC Educational Resources Information Center

Zook, Avery, II; Sipps, Gary J.

1985-01-01

Presents a cross-validation of Reynolds' short form of the Marlowe-Crowne Social Desirability Scale (N=233). Researchers administered 13 items as a separate entity, calculated Cronbach's Alpha for each sex, and computed test-retest correlation for one group. Concluded that the short form is a viable alternative. (Author/NRB)

A Recommendation for Managing the Predicted Growth in College Enrollment at a Time of Adverse Economic Conditions.

ERIC Educational Resources Information Center

Jones, Randolph

2003-01-01

Explores the option of using distance education courses as a viable alternative to building classrooms and facilities. Distance education could be one solution to the financial and physical facilities problems universities may have in dealing with the predicted economic and enrollment conditions. (AEF)

Poultry litter application to loblolly pine forests: growth and nutrient containment

Treesearch

Alexander L. Friend; Scott D. Roberts; Stephen H. Schoenholtz; Juanita A. Mobley; Patrick D. Gerard

2006-01-01

Forestland application of poultry manure offers an alternative to the conventional practice of pastureland application. Before such a practice is considered viable, however, it must be demonstrated that the forest ecosystem is capable of absorbing the nutrients contained in poultry manure, especially nitrogen (N) and phosphorus (P). From the forestry perspective, it...

Peer Mentoring--Is a Virtual Form of Support a Viable Alternative?

ERIC Educational Resources Information Center

Smailes, Joanne; Gannon-Leary, Pat

2011-01-01

Support systems are vital for university entrants and one established means of support is peer mentoring, which has the potential to improve student engagement and retention. Peer mentoring models are generally based on face-to-face contact. However, given the increasing number of higher education institutions using social media, might online…

Does Performance-Based Pay Improve Teaching? PISA in Focus. No. 16

ERIC Educational Resources Information Center

OECD Publishing (NJ1), 2012

2012-01-01

The Programme for International Student Assessment (PISA) has long established that high-performing education systems tend to pay their teachers more. They also often prioritise the quality of teaching over other choices, including class size. But in the current budgetary climate, paying everybody more may not be a viable alternative. So many…

Use of Social Welfare Programs and the Disintegration of the Black Nuclear Family.

ERIC Educational Resources Information Center

Jewell, K. Sue

1984-01-01

Social welfare programs contribute to Black women's decisions to terminate their marriages by modifying existing beliefs and values, giving rise to a perception of welfare as a more viable alternative to marital relationships. But welfare is insufficient to enable the maintenance of Black women's preseparation standard of living. (RDN)

Comparing Vignette Instruction and Assessment Tasks to Classroom Observations and Reflections

ERIC Educational Resources Information Center

Jeffries, Carolyn; Maeder, Dale W.

2011-01-01

The growing body of research on the use of vignettes in teacher education courses suggests that vignette-based instruction and assessment tasks may represent a viable alternative to traditional forms of scaffolded instruction and reflective essays following classroom observations, thereby creating a bridge between college and K-12 classrooms for…

Flow Injection Analysis and Liquid Chromatography for Multifunctional Chemical Analysis (MCA) Systems

ERIC Educational Resources Information Center

Mayo, Ana V.; Loegel, Thomas N.; Bretz, Stacey Lowery; Danielson, Neil D.

2013-01-01

The large class sizes of first-year chemistry labs makes it challenging to provide students with hands-on access to instrumentation because the number of students typically far exceeds the number of research-grade instruments available to collect data. Multifunctional chemical analysis (MCA) systems provide a viable alternative for large-scale…

LED roadway luminaires evaluation.

DOT National Transportation Integrated Search

2012-02-01

This research explores whether LED roadway luminaire technologies are a viable future solution to providing roadway lighting. Roadway lighting : enhances highway safety and traffic flow during limited lighting conditions. The purpose of this evaluati...

Effects of alternative outcome scenarios and structured outcome evaluation on case-based ethics instruction.

PubMed

Peacock, Juandre; Harkrider, Lauren N; Bagdasarov, Zhanna; Connelly, Shane; Johnson, James F; Thiel, Chase E; Macdougall, Alexandra E; Mumford, Michael D; Devenport, Lynn D

2013-09-01

Case-based instruction has been regarded by many as a viable alternative to traditional lecture-based education and training. However, little is known about how case-based training techniques impact training effectiveness. This study examined the effects of two such techniques: (a) presentation of alternative outcome scenarios to a case, and (b) conducting a structured outcome evaluation. Consistent with the hypotheses, results indicate that presentation of alternative outcome scenarios reduced knowledge acquisition, reduced sensemaking and ethical decision-making strategy use, and reduced decision ethicality. Conducting a structured outcome evaluation had no impact on these outcomes. Results indicate that those who use case-based instruction should take care to use clear, less complex cases with only a singular outcome if they are seeking these types of outcomes.

Ocean energy program summary. Volume 2: Research summaries

NASA Astrophysics Data System (ADS)

1990-01-01

The oceans are the world's largest solar energy collector and storage system. Covering 71 percent of the earth's surface, this stored energy is realized as waves, currents, and thermal salinity gradients. The purpose of the Federal Ocean Energy Technology (OET) Program is to develop techniques that harness this ocean energy in a cost effective and environmentally acceptable manner. The OET Program seeks to develop ocean energy technology to a point where the commercial sector can assess whether applications of the technology are viable energy conversion alternatives or supplements to systems. Past studies conducted by the U.S. Department of Energy (DOE) have identified ocean thermal energy conversion (OTEC) as the largest potential contributor to United States energy supplies from the ocean resource. As a result, the OET Program concentrates on research to advance OTEC technology. Current program emphasis has shifted to open-cycle OTEC power system research because the closed-cycle OTEC system is at a more advanced stage of development and has already attracted industrial interest. During FY 1989, the OET Program focused primarily on the technical uncertainties associated with near-shore open-cycle OTEC systems ranging in size from 2 to 15 MW(sub e). Activities were performed under three major program elements: thermodynamic research and analysis, experimental verification and testing, and materials and structures research. These efforts addressed a variety of technical problems whose resolution is crucial to demonstrating the viability of open-cycle OTEC technology. This publications is one of a series of documents on the Renewable Energy programs sponsored by the U.S. Department of Energy. An overview of all the programs is available, entitled Programs in Renewable Energy.

Information Technology Student-Based Certification in Formal Education Settings: Who Benefits and What Is Needed

ERIC Educational Resources Information Center

Randall, Michael H.; Zirkle, Christopher J.

2005-01-01

There is a growing trend within secondary and post-secondary institutions to offer information technology (IT) certification programs as instructional vehicles to provide students with viable skills needed by the workforce, to satisfy state skill standards, and to prepare students for post-secondary IT studies. The use of IT certification programs…

Defense Systems Modernization and Sustainment Initiative

DTIC Science & Technology

2014-03-31

research programs focus on sustainable production, sustainable energy, sustainable mobility , and ecologically friendly information technology systems...for Sustainable Mobility (CSM): focused on developing viable technologies for sustainable transportation systems and the support of complex equipment...utilization of mobile devices. The objective of the evaluation was to identify features that the new implementation of LEEDS would require, such as

Bioethics and deliberative democracy: five warnings from Hobbes.

PubMed

Trotter, Griffin

2006-06-01

Thomas Hobbes is one of the most ardent and thoroughgoing opponents of participatory democracy among Western political philosophers. Though Hobbes's alternative to participatory democracy-assent by subjects to rule by an absolute sovereign-no longer constitutes a viable political alternative for Westerners, his critique of participatory democracy is a potentially valuable source of insight about its liabilities. This essay elaborates five theses from Hobbes that stand as cogent warnings to those who embrace participatory democracy, especially those (such as most bioethicists) advocating for deliberative democracy based on a rational consensus model. In light of these warnings, the author suggests an alternative, modus vivendi approach to deliberative democracy that would radically alter the current practice of bioethics.

Free-space optics technology employed in an UMTS release 4 bearer independent core network access part

NASA Astrophysics Data System (ADS)

Bibac, Ionut

2005-08-01

The UMTS Bearer Independent Core Network program introduced the 3rd Generation Partnership Program Release 4 BICN architecture into the legacy UMTS TDM-switched network. BICN is the application of calI server archltecture for voice and circuit switched data, enabling the provisioning of traditional circuit-switched services using a packet-switched transport network. Today"s business climate has made it essential for service providers to develop a comprehensive networking strategy that means introduction of RCBICN networks. The R4-BICN solution to the evolution of the Core Network in UMTS will enable operators to significantly reduce the capital and operational costs of delivering both traditional voice sewices and new multimedia services. To build the optical backbone, which can support the third generation (3G) packetized infrastructure, the operators could choose a fibre connection, or they could retain the benefits of a wireless connectivity by using a FSO - Free Space Optical lmk, the only wireless technology available that is capable of achieving data rates up to 2.4 Gbit/s. FSO offers viable alternatives for both core transmission networks and for replacing microwaves links in NodeB - RNC access networks. The paper and presentation aim to demonstrate the manner in which FSO products and networks are employed into R4-BICN design solutions.

Plasma vitrification of asbestos fibers

DOE Office of Scientific and Technical Information (OSTI.GOV)

Camacho, S.L.

Asbestos is a mineral in the form of long, thread-like fibers. Asbestos fibers have been among the best insulators of pipes, boilers, ducts, tanks, etc., in buildings, ships, and industrial furnaces. Over 150,000 metric tons of asbestos were consumed in the United States in 1984. The Environmental Protection Agency has declared asbestos fibers a known human carcinogen. And today, asbestos insulators are being replaced by manmade non-hazardous fibers. Millions of tons of replaced asbestos fiber insulators are in storage, awaiting the demonstration of effective alternative disposal technologies. Plasma vitrification has been demonstrated during May, June and July 1995 as amore » viable, cost-effective, safe technology for asbestos fiber disposal. A low-mass plasma arc heater is submerged under the waste asbestos insulating materials, and the intense heat of the plasma flame heats and melts the fibers. The by-product is dark, non-hazardous glass pellets. The vitrification process renders the asbestos waste safe for use as road construction aggregates or other fill materials. This paper will describe the results of start-up of a 1 ton-per-hour Plasma Mobile Asbestos Vitrification (MAV) Plant at a DOD Site in Port Clinton, Ohio. The Plasma MAV Plant is being demonstrated for the on-site disposal of 1.5 million pounds of Amosite asbestos fibers.« less

Noninvasive prenatal diagnosis for single gene disorders.

PubMed

Allen, Stephanie; Young, Elizabeth; Bowns, Benjamin

2017-04-01

Noninvasive prenatal diagnosis for single gene disorders is coming to fruition in its clinical utility. The presence of cell-free DNA in maternal plasma has been recognized for many years, and a number of applications have developed from this. Noninvasive prenatal diagnosis for single gene disorders has lagged behind due to complexities of technology development, lack of investment and the need for validation samples for rare disorders. Publications are emerging demonstrating a variety of technical approaches and feasibility of clinical application. Techniques for analysis of cell-free DNA including digital PCR, next-generation sequencing and relative haplotype dosage have been used most often for assay development. Analysis of circulating fetal cells in the maternal blood is still being investigated as a viable alternative and more recently transcervical trophoblast cells. Studies exploring ethical and social issues are generally positive but raise concerns around the routinization of prenatal testing. Further work is necessary to make testing available to all patients with a pregnancy at risk of a single gene disorder, and it remains to be seen if the development of more powerful technologies such as isolation and analysis of single cells will shift the emphasis of noninvasive prenatal diagnosis. As testing becomes possible for a wider range of conditions, more ethical questions will become relevant.

Dropwise additive manufacturing of pharmaceutical products for solvent-based dosage forms.

PubMed

Hirshfield, Laura; Giridhar, Arun; Taylor, Lynne S; Harris, Michael T; Reklaitis, Gintaras V

2014-02-01

In recent years, the US Food and Drug Administration has encouraged pharmaceutical companies to develop more innovative and efficient manufacturing methods with improved online monitoring and control. Mini-manufacturing of medicine is one such method enabling the creation of individualized product forms for each patient. This work presents dropwise additive manufacturing of pharmaceutical products (DAMPP), an automated, controlled mini-manufacturing method that deposits active pharmaceutical ingredients (APIs) directly onto edible substrates using drop-on-demand (DoD) inkjet printing technology. The use of DoD technology allows for precise control over the material properties, drug solid state form, drop size, and drop dynamics and can be beneficial in the creation of high-potency drug forms, combination drugs with multiple APIs or individualized medicine products tailored to a specific patient. In this work, DAMPP was used to create dosage forms from solvent-based formulations consisting of API, polymer, and solvent carrier. The forms were then analyzed to determine the reproducibility of creating an on-target dosage form, the morphology of the API of the final form and the dissolution behavior of the drug over time. DAMPP is found to be a viable alternative to traditional mass-manufacturing methods for solvent-based oral dosage forms. © 2013 Wiley Periodicals, Inc. and the American Pharmacists Association.

Novel arrangement for an electro-Fenton reactor that does not require addition of iron, acid and a final neutralization stage. Towards the development of a cost-effective technology for the treatment of wastewater.

PubMed

Fernández, Dennys; Robles, Irma; Rodríguez-Valadez, Francisco J; Godínez, Luis A

2018-05-01

A novel arrangement for an electro-Fenton reactor aimed to treat neutral wastewater is presented. The arrangement consists on three-compartments in series, two of them packed with a cation exchange resin and one positioned between these, containing a polarized activated carbon column where the electrochemical generation of the Fenton reagent takes place. While the hydroxyl radicals electrochemically produced in-situ, react with the pollutant species adsorbed on the activated carbon cathode, the resin compartments administrate and collect the iron cation and the hydrated proton species in alternating flow direction cycles. The resulting process is a system that does not require acid or iron chemical addition to the process while at the same time, renders decontaminated water free of iron-dissolved species at neutral pH. The proposed electrochemical reactor arrangement is therefore the basis for the design of commercially viable electro-Fenton reactors in which the addition and subsequent removal of acid and iron chemicals is avoided; two of the currently most limiting features for the development of electro-Fenton technology for treating wastewater. Copyright © 2018 The Authors. Published by Elsevier Ltd.. All rights reserved.

Pulsed Light Treatment of Different Food Types with a Special Focus on Meat: A Critical Review.

PubMed

Heinrich, V; Zunabovic, M; Varzakas, T; Bergmair, J; Kneifel, W

2016-01-01

Today, the increasing demand for minimally processed foods that are at the same moment nutritious, organoleptically satisfactory, and free from microbial hazards challenges the research and development to establish alternative methods to reduce the level of bacterial contamination. As one of the recent emerging nonthermal methods, pulsed light (PL) constitutes a technology for the fast, mild, and residue-free surface decontamination of food and food contact materials in the processing environment. Via high frequency, high intensity pulses of broad-spectrum light rich in the UV fraction, viable cells as well as spores are inactivated in a nonselective multi-target process that rapidly overwhelms cell functions and subsequently leads to cell death. This review provides specific information on the technology of pulsed light and its suitability for unpackaged and packaged meat and meat products as well as food contact materials like production surfaces, cutting tools, and packaging materials. The advantages, limitations, risks, and essential process criteria to work efficiently are illustrated and discussed with relation to implementation on industrial level and future aspects. Other issues addressed by this paper are the need to take care of the associated parameters such as alteration of the product and utilized packaging material to satisfy consumers and other stakeholders.

[QUATERNARY PREVENTION: AN ATTEMPT TO AVOID THE EXCESSES OF MEDICINE].

PubMed

Noble, María

2015-01-01

Seduced by technology, biometrics, practical guidelines and the use of medication, medicine has been driven away from the subject of its care. Quaternary prevention is, among other voices around the world, trying to denounce the consequent excesses of medical practice given by this situation. There are visible excesses, such as the long list of studies being performed on patients without indication, and others, much more subtle, as excessive prevention and the continuous and progressive medicalization of life itself that are rooted in our culture and demanded by a society that requests certainty at almost any cost. Quaternary prevention proposes a series of actions leaning towards avoiding and diminishing the damage produced by health care activities, in order to protect the subject of overdiagnosis and overtreatment; offering also ethical and viable alternatives in which the balance of risks and benefits (based on the best evidences) respects the autonomy of the subject by properly informing and allowing him to decide among the best options he has; altogether in a process that contemplates a rational and equitable use of resources. In order to achieve this, reliable sources of information and a medical education not dependent on industries related to technology or pharmaceuticals, are vital; in conjuction with a medicine that restablishes the subject as its main and central interest.

[Quaternary prevention: An attempt to avoid the excesses of Medicine].

PubMed

Noble, María

2015-09-01

Seduced by technology, biometrics, practical guidelines and the use of medication, medicine has been driven away from the subject of its care. Quaternary prevention is, among other voices around the world, trying to denounce the consequent excesses of medical practice given by this situation. There are visible excesses, such as the long list of studies being performed on patients without indication, and others, much more subtle, as excessive prevention and the continuous and progressive medicalization of life itself that are rooted in our culture and demanded by a society that requests certainty at almost any cost. Quaternary prevention proposes a series of actions leaning towards avoiding and diminishing the damage produced by health care activities, in order to protect the subject of overdiagnosis and overtreatment; offering also ethical and viable alternatives in which the balance of risks and benefits (based on the best evidences) respects the autonomy of the subject by properly informing and allowing him to decide among the best options he has; altogether in a process that contemplates a rational and equitable use of resources. In order to achieve this, reliable sources of information and a medical education not dependent on industries related to technology or pharmaceuticals, are vital; in conjuction with a medicine that restablishes the subject as its main and central interest.

Technological advances that enhance teaching using animals, and the application of the Three Rs.

PubMed

Davies, Alexander S

2004-06-01

The inventions that have progressively contributed to education have never offered opportunities as vast as in the digital era, even though this is still scarcely 25 years old. In this time, digital handling of data led first to text processing, then to bitmap and vector graphics, and now, to digital sound and movies. As these advanced, the storage methods became larger, faster, easier and cheaper. The advancement of technology has been so rapid that the standard of most teaching aids now available is well below what can currently be achieved. We are confronted with an unprecedented opportunity for applying the principles of reduction, refinement and replacement of animals in education. Not only are the visual teaching aids improved by digitising, but all aspects of their development, including the ease, higher speed, and low cost of creation, editing, copying, distribution and access, are improved, as well. Several examples will be given, including access to interactive panoramic movies, animated sequences to explain difficult concepts, on-line tutorials and image databases using digital photography, radiography and other diagnostic methods, as well as the production of desktop movies. The speed of technical advance brings its own problems, but the challenges and possibilities for developing viable alternatives to the use of animals in teaching are vast.

Alternative Fuels Data Center: Ten Ways You Can Implement Alternative Fuels

Science.gov Websites

and Energy-Efficient Vehicle Technologies Ten Ways You Can Implement Alternative Fuels and Energy-Efficient Vehicle Technologies to someone by E-mail Share Alternative Fuels Data Center: Ten Ways You Can Implement Alternative Fuels and Energy-Efficient Vehicle Technologies on Facebook Tweet about

Offline pentafluorophenyl (PFP)-RP prefractionation as an alternative to high-pH RP for comprehensive LC-MS/MS proteomics and phosphoproteomics.

PubMed

Grassetti, Andrew V; Hards, Rufus; Gerber, Scott A

2017-07-01

Technological advances in liquid chromatography and tandem mass spectrometry (LC-MS/MS) have enabled comprehensive analyses of proteins and their post-translational modifications from cell culture and tissue samples. However, sample complexity necessitates offline prefractionation via a chromatographic method that is orthogonal to online reversed-phase high-performance liquid chromatography (RP-HPLC). This additional fractionation step improves target identification rates by reducing the complexity of the sample as it is introduced to the instrument. A commonly employed offline prefractionation method is high pH reversed-phase (Hi-pH RP) chromatography. Though highly orthogonal to online RP-HPLC, Hi-pH RP relies on buffers that interfere with electrospray ionization. Thus, samples that are prefractionated using Hi-pH RP are typically desalted prior to LC-MS/MS. In the present work, we evaluate an alternative offline prefractionation method, pentafluorophenyl (PFP)-based reversed-phase chromatography. Importantly, PFP prefractionation results in samples that are dried prior to analysis by LC-MS/MS. This reduction in sample handling relative to Hi-pH RP results in time savings and could facilitate higher target identification rates. Here, we have compared the performances of PFP and Hi-pH RP in offline prefractionation of peptides and phosphopeptides that have been isolated from human cervical carcinoma (HeLa) cells. Given the prevalence of isobaric mass tags for peptide quantification, we evaluated PFP chromatography of peptides labeled with tandem mass tags. Our results suggest that PFP is a viable alternative to Hi-pH RP for both peptide and phosphopeptide offline prefractionation.

Corrective Action Investigation Plan for Corrective Action Unit 560: Septic Systems, Nevada Test Site, Nevada with ROTC1, Revision 0

DOE Office of Scientific and Technical Information (OSTI.GOV)

Grant Evenson

2008-05-01

Corrective Action Unit (CAU) 560 is located in Areas 3 and 6 of the Nevada Test Site, which is approximately 65 miles northwest of Las Vegas, Nevada. Corrective Action Unit 560 is comprised of the seven corrective action sites (CASs) listed below: • 03-51-01, Leach Pit • 06-04-02, Septic Tank • 06-05-03, Leach Pit • 06-05-04, Leach Bed • 06-59-03, Building CP-400 Septic System • 06-59-04, Office Trailer Complex Sewage Pond • 06-59-05, Control Point Septic System These sites are being investigated because existing information on the nature and extent of potential contamination is insufficient to evaluate and recommend correctivemore » action alternatives. Additional information will be obtained by conducting a corrective action investigation before evaluating corrective action alternatives and selecting the appropriate corrective action for each CAS. The results of the field investigation will support a defensible evaluation of viable corrective action alternatives that will be presented in the Corrective Action Decision Document. The sites will be investigated based on the data quality objectives (DQOs) developed on January 22, 2008, by representatives from the Nevada Division of Environmental Protection; U.S. Department of Energy (DOE), National Nuclear Security Administration Nevada Site Office; Stoller-Navarro Joint Venture; and National Security Technologies, LLC. The DQO process was used to identify and define the type, amount, and quality of data needed to develop and evaluate appropriate corrective actions for CAU 560.« less

Investigation of Removal Capacities of Biofilters for Airborne Viable Micro-Organisms

PubMed Central

Soret, Rémi; Fanlo, Jean-Louis; Malhautier, Luc; Geiger, Philippe; Bayle, Sandrine

2018-01-01

New emerging issues appears regarding the possible aerosolization of micro-organisms from biofilters to the ambient air. Traditional bioaerosol sampling and cultural methods used in literature offer relative efficiencies. In this study, a new method revolving around a particle counter capable of detecting total and viable particles in real time was used. This counter (BioTrak 9510-BD) uses laser-induced fluorescence (LIF) technology to determine the biological nature of the particle. The concentration of viable particles was measured on two semi-industrial pilot scale biofilters in order to estimate the Removal Efficiency in viable particles (REvp) in stable conditions and to examine the influence of pollutant feeding and relative humidification of the gaseous effluent on the REvp. The REvp of biofilters reached near 80% and highlighted both the stability of that removal and the statistical equivalence between two identical biofilters. Pollutant deprivation periods of 12 h, 48 h and 30 days were shown to have no influence on the biofilters’ removal capacity, demonstrating the robustness and adaptation capacities of the flora. In contrast, a 90-day famine period turned the biofilters into emitters of viable particles. Finally, the humidification of the effluent was shown to negatively influence the removal capacity for viable particles, as drying off the air was shown to increase the REvp from 60 to 85%. PMID:29562709

Survey of Thermoelectric and Solar Technologies as Alternative Energy Solutions

DTIC Science & Technology

2012-02-01

Survey of Thermoelectric and Solar Technologies as Alternative Energy Solutions by Kendall Bianchi, Jay R. Maddux, Kimberly Sablon-Ramsey...Research Laboratory Adelphi, MD 20783-1197 ARL-TR-5920 February 2012 Survey of Thermoelectric and Solar Technologies as Alternative Energy...Final 3. DATES COVERED (From - To) 4. TITLE AND SUBTITLE Survey of Thermoelectric and Solar Technologies as Alternative Energy Solutions 5a

Micro and nanotechnologies in heart valve tissue engineering.

PubMed

Hasan, Anwarul; Saliba, John; Pezeshgi Modarres, Hassan; Bakhaty, Ahmed; Nasajpour, Amir; Mofrad, Mohammad R K; Sanati-Nezhad, Amir

2016-10-01

Due to the increased morbidity and mortality resulting from heart valve diseases, there is a growing demand for off-the-shelf implantable tissue engineered heart valves (TEHVs). Despite the significant progress in recent years in improving the design and performance of TEHV constructs, viable and functional human implantable TEHV constructs have remained elusive. The recent advances in micro and nanoscale technologies including the microfabrication, nano-microfiber based scaffolds preparation, 3D cell encapsulated hydrogels preparation, microfluidic, micro-bioreactors, nano-microscale biosensors as well as the computational methods and models for simulation of biological tissues have increased the potential for realizing viable, functional and implantable TEHV constructs. In this review, we aim to present an overview of the importance and recent advances in micro and nano-scale technologies for the development of TEHV constructs. Copyright © 2016 Elsevier Ltd. All rights reserved.

Specific detection of viable Listeria monocytogenes in Spanish wastewater treatment plants by Fluorescent In Situ Hybridization and PCR.

PubMed

Moreno, Yolanda; Ballesteros, Lorena; García-Hernández, Jorge; Santiago, Paula; González, Ana; Ferrús, M Antonia

2011-10-01

Listeria monocytogenes detection in wastewater can be difficult because of the large amount of background microbiota and the presence of viable but non-culturable forms in this environment. The aim of this study was to evaluate a Fluorescent In Situ Hybridization (FISH) assay combined with Direct Viable Count (DVC) method for detecting viable L. monocytogenes in wastewater samples, as an alternative to conventional culture methods. 16S rRNA sequence data were used to design a specific oligonucleotide probe. In order to assess the suitability of the method, the assays were performed on naturally (n=87) and artificially (n=14) contaminated samples and results were compared to those obtained with the isolation of cells on selective media and with a PCR method. The detection limit of FISH and PCR assays was 10(4) cells/mL without enrichment and 10 cells/mL after enrichment. A total of 47 samples, including 3 samples from effluent sites, yielded FISH positive results for L. monocytogenes. Using DVC-FISH technique, the presence of viable L. monocytogenes cells was detected in 23 out of these 47 FISH positive wastewater samples. PCR and culture methods yielded 27 and 23 positive results, respectively. According to these results, FISH technique has the potential to be used as a sensitive method for the detection and enumeration of L. monocytogenes in environmental wastewater samples. Copyright © 2011 Elsevier Ltd. All rights reserved.

40 CFR 136.5 - Approval of alternate test procedures.

Code of Federal Regulations, 2011 CFR

2011-07-01

... and to the Alternate Test Procedure Program Coordinator, Office of Science and Technology (4303... to the Alternate Test Procedure Program Coordinator, Office of Science and Technology (4303), Office... will be forwarded to the Alternate Test Procedure Program Coordinator, Office of Science and Technology...

40 CFR 136.5 - Approval of alternate test procedures.

Code of Federal Regulations, 2010 CFR

2010-07-01

... and to the Alternate Test Procedure Program Coordinator, Office of Science and Technology (4303... to the Alternate Test Procedure Program Coordinator, Office of Science and Technology (4303), Office... will be forwarded to the Alternate Test Procedure Program Coordinator, Office of Science and Technology...

IMPAC: An Integrated Methodology for Propulsion and Airframe Control

NASA Technical Reports Server (NTRS)

Garg, Sanjay; Ouzts, Peter J.; Lorenzo, Carl F.; Mattern, Duane L.

1991-01-01

The National Aeronautics and Space Administration is actively involved in the development of enabling technologies that will lead towards aircraft with new/enhanced maneuver capabilities such as Short Take-Off Vertical Landing (STOVL) and high angle of attack performance. Because of the high degree of dynamic coupling between the airframe and propulsion systems of these types of aircraft, one key technology is the integration of the flight and propulsion control. The NASA Lewis Research Center approach to developing Integrated Flight Propulsion Control (IFPC) technologies is an in-house research program referred to as IMPAC (Integrated Methodology for Propulsion and Airframe Control). The goals of IMPAC are to develop a viable alternative to the existing integrated control design methodologies that will allow for improved system performance and simplicity of control law synthesis and implementation, and to demonstrate the applicability of the methodology to a supersonic STOVL fighter aircraft. Based on some preliminary control design studies that included evaluation of the existing methodologies, the IFPC design methodology that is emerging at the Lewis Research Center consists of considering the airframe and propulsion system as one integrated system for an initial centralized controller design and then partitioning the centralized controller into separate airframe and propulsion system subcontrollers to ease implementation and to set meaningful design requirements for detailed subsystem control design and evaluation. An overview of IMPAC is provided and detailed discussion of the various important design and evaluation steps in the methodology are included.

Dynamic behavior of gasoline fuel cell electric vehicles

NASA Astrophysics Data System (ADS)

Mitchell, William; Bowers, Brian J.; Garnier, Christophe; Boudjemaa, Fabien

As we begin the 21st century, society is continuing efforts towards finding clean power sources and alternative forms of energy. In the automotive sector, reduction of pollutants and greenhouse gas emissions from the power plant is one of the main objectives of car manufacturers and innovative technologies are under active consideration to achieve this goal. One technology that has been proposed and vigorously pursued in the past decade is the proton exchange membrane (PEM) fuel cell, an electrochemical device that reacts hydrogen with oxygen to produce water, electricity and heat. Since today there is no existing extensive hydrogen infrastructure and no commercially viable hydrogen storage technology for vehicles, there is a continuing debate as to how the hydrogen for these advanced vehicles will be supplied. In order to circumvent the above issues, power systems based on PEM fuel cells can employ an on-board fuel processor that has the ability to convert conventional fuels such as gasoline into hydrogen for the fuel cell. This option could thereby remove the fuel infrastructure and storage issues. However, for these fuel processor/fuel cell vehicles to be commercially successful, issues such as start time and transient response must be addressed. This paper discusses the role of transient response of the fuel processor power plant and how it relates to the battery sizing for a gasoline fuel cell vehicle. In addition, results of fuel processor testing from a current Renault/Nuvera Fuel Cells project are presented to show the progress in transient performance.

Kinetics of killing Listeria monocytogenes by macrophages: correlation of /sup 3/H-DNA release from labeled bacteria and changes in numbers of viable organisms by mathematical model

DOE Office of Scientific and Technical Information (OSTI.GOV)

Davies, W.A.

1982-12-01

Conventional methods of assessing antibacterial activities of macrophages by viable counting are limited by the precision of the statistics and are difficult to interpret quantitatively because of unrestrained extracellular growth of bacteria. An alternative technique based on the release of radioactive DNA from labeled bacteria has been offered as overcoming these drawbacks. To assess it for use with macrophages I have made a correlation with the conventional viable counting method using a mathematical model. Opsonized Listeria monocytogenes labeled with /sup 3/H-thymidine were exposed to rat macrophages for periods up to 4 hr. Numbers of viable bacteria determined after sonication increasedmore » exponentially in the absence of live cells and this growth rate was progressively inhibited by increasing numbers of macrophages. After a lag period of 30-60 min soluble /sup 3/H appeared in the supernatant, the amount increasing with time and numbers of macrophages. To correlate these data I developed a mathematical model that considered that changes in numbers of viable organisms were due to the difference between rates of 1) growth of extracellular bacteria and 2) killing within the macrophage. On the basis of this model curves of best fit to the viable counts data were used to predict the release of radioactivity, assuming that death of a bacterium led to the total release of its label. These predictions and the experimental data agreed well, the lag period of 30-60 min between death of the bacterium and release of radioactivity being consistent with intracellular digestion. Release of soluble radioactivity appears to be an accurate reflection of the number of bacteria killed within the macrophage.« less