Sample records for viable commercial applications

  1. Rapid assessment of viable but non-culturable Bacillus coagulans MTCC 5856 in commercial formulations using Flow cytometry.

    PubMed

    Majeed, Muhammed; Majeed, Shaheen; Nagabhushanam, Kalyanam; Punnapuzha, Ardra; Philip, Sheena; Mundkur, Lakshmi

    2018-01-01

    Accurate enumeration of bacterial count in probiotic formulation is imperative to ensure that the product adheres to regulatory standards and citation in consumer product label. Standard methods like plate count, can enumerate only replicating bacterial population under selected culture conditions. Viable but non culturable bacteria (VBNC) retain characteristics of living cells and can regain cultivability by a process known as resuscitation. This is a protective mechanism adapted by bacteria to evade stressful environmental conditions. B. coagulans MTCC 5856(LactoSpore®) is a probiotic endospore which can survive for decades in hostile environments without dividing. In the present study, we explored the use of flow cytometry to enumerate the viable count of B. coagulans MTCC 5856 under acidic and alkaline conditions, high temperature and in commercial formulations like compressed tablets and capsules. Flow cytometry (FCM) was comparable to plate count method when the spores were counted at physiological conditions. We show that VBNC state is induced in B. coagulans MTCC 5856by high temperature and acidic pH. The cells get resuscitated under physiological conditions and FCM was sensitive to detect the VBNC spores. Flow cytometry showed excellent ability to assess the viable spore count in commercial probiotic formulations of B. coagulans MTCC 5856. The results establish Flow cytometry as a reliable method to count viable bacteria in commercial probiotic preparations. Sporulation as well as existence as VBNC could contribute to the extreme stability of B. coagulans MTCC 5856.

  2. Rapid assessment of viable but non-culturable Bacillus coagulans MTCC 5856 in commercial formulations using Flow cytometry

    PubMed Central

    Majeed, Muhammed; Majeed, Shaheen; Nagabhushanam, Kalyanam; Punnapuzha, Ardra; Philip, Sheena

    2018-01-01

    Accurate enumeration of bacterial count in probiotic formulation is imperative to ensure that the product adheres to regulatory standards and citation in consumer product label. Standard methods like plate count, can enumerate only replicating bacterial population under selected culture conditions. Viable but non culturable bacteria (VBNC) retain characteristics of living cells and can regain cultivability by a process known as resuscitation. This is a protective mechanism adapted by bacteria to evade stressful environmental conditions. B. coagulans MTCC 5856(LactoSpore®) is a probiotic endospore which can survive for decades in hostile environments without dividing. In the present study, we explored the use of flow cytometry to enumerate the viable count of B. coagulans MTCC 5856 under acidic and alkaline conditions, high temperature and in commercial formulations like compressed tablets and capsules. Flow cytometry (FCM) was comparable to plate count method when the spores were counted at physiological conditions. We show that VBNC state is induced in B. coagulans MTCC 5856by high temperature and acidic pH. The cells get resuscitated under physiological conditions and FCM was sensitive to detect the VBNC spores. Flow cytometry showed excellent ability to assess the viable spore count in commercial probiotic formulations of B. coagulans MTCC 5856. The results establish Flow cytometry as a reliable method to count viable bacteria in commercial probiotic preparations. Sporulation as well as existence as VBNC could contribute to the extreme stability of B. coagulans MTCC 5856. PMID:29474436

  3. Development of a Commercially Viable, Modular Autonomous Robotic Systems for Converting any Vehicle to Autonomous Control

    NASA Technical Reports Server (NTRS)

    Parish, David W.; Grabbe, Robert D.; Marzwell, Neville I.

    1994-01-01

    A Modular Autonomous Robotic System (MARS), consisting of a modular autonomous vehicle control system that can be retrofit on to any vehicle to convert it to autonomous control and support a modular payload for multiple applications is being developed. The MARS design is scalable, reconfigurable, and cost effective due to the use of modern open system architecture design methodologies, including serial control bus technology to simplify system wiring and enhance scalability. The design is augmented with modular, object oriented (C++) software implementing a hierarchy of five levels of control including teleoperated, continuous guidepath following, periodic guidepath following, absolute position autonomous navigation, and relative position autonomous navigation. The present effort is focused on producing a system that is commercially viable for routine autonomous patrolling of known, semistructured environments, like environmental monitoring of chemical and petroleum refineries, exterior physical security and surveillance, perimeter patrolling, and intrafacility transport applications.

  4. Physiology limits commercially viable photoautotrophic production of microalgal biofuels.

    PubMed

    Kenny, Philip; Flynn, Kevin J

    2017-01-01

    Algal biofuels have been offered as an alternative to fossil fuels, based on claims that microalgae can provide a highly productive source of compounds as feedstocks for sustainable transport fuels. Life cycle analyses identify algal productivity as a critical factor affecting commercial and environmental viability. Here, we use mechanistic modelling of the biological processes driving microalgal growth to explore optimal production scenarios in an industrial setting, enabling us to quantify limits to algal biofuels potential. We demonstrate how physiological and operational trade-offs combine to restrict the potential for solar-powered algal-biodiesel production in open ponds to a ceiling of ca. 8000 L ha -1 year -1 . For industrial-scale operations, practical considerations limit production to ca. 6000 L ha -1 year -1 . According to published economic models and life cycle analyses, such production rates cannot support long-term viable commercialisation of solar-powered cultivation of natural microalgae strains exclusively as feedstock for biofuels. The commercial viability of microalgal biofuels depends critically upon limitations in microalgal physiology (primarily in rates of C-fixation); we discuss the scope for addressing this bottleneck concluding that even deployment of genetically modified microalgae with radically enhanced characteristics would leave a very significant logistical if not financial burden.

  5. Are commercial providers a viable option for clinical bacterial sequencing?

    PubMed

    Raven, Kathy; Blane, Beth; Churcher, Carol; Parkhill, Julian; Peacock, Sharon J

    2018-04-05

    Bacterial whole-genome sequencing in the clinical setting has the potential to bring major improvements to infection control and clinical practice. Sequencing instruments are not currently available in the majority of routine microbiology laboratories worldwide, but an alternative is to use external sequencing providers. To foster discussion around this we investigated whether send-out services were a viable option. Four providers offering MiSeq sequencing were selected based on cost and evaluated based on the service provided and sequence data quality. DNA was prepared from five methicillin-resistant Staphylococcus aureus (MRSA) isolates, four of which were investigated during a previously published outbreak in the UK together with a reference MRSA isolate (ST22 HO 5096 0412). Cost of sequencing per isolate ranged from £155 to £342 and turnaround times from DNA postage to arrival of sequence data ranged from 12 to 63 days. Comparison of commercially generated genomes against the original sequence data demonstrated very high concordance, with no more than one single nucleotide polymorphism (SNP) difference on core genome mapping between the original sequences and the new sequence for all four providers. Multilocus sequence type could not be assigned based on assembly for the two cheapest sequence providers due to fragmented assemblies probably caused by a lower output of sequence data per isolate. Our results indicate that external providers returned highly accurate genome data, but that improvements are required in turnaround time to make this a viable option for use in clinical practice.

  6. JPL - Small Power Systems Applications Project. [for solar thermal power plant development and commercialization

    NASA Technical Reports Server (NTRS)

    Ferber, R. R.; Marriott, A. T.; Truscello, V.

    1978-01-01

    The Small Power Systems Applications (SPSA) Project has been established to develop and commercialize small solar thermal power plants. The technologies of interest include all distributed and central receiver technologies which are potentially economically viable in power plant sizes of one to 10 MWe. The paper presents an overview of the SPSA Project and briefly discusses electric utility involvement in the Project.

  7. Elastic memory composites (EMC) for deployable industrial and commercial applications

    NASA Astrophysics Data System (ADS)

    Arzberger, Steven C.; Tupper, Michael L.; Lake, Mark S.; Barrett, Rory; Mallick, Kaushik; Hazelton, Craig; Francis, William; Keller, Phillip N.; Campbell, Douglas; Feucht, Sara; Codell, Dana; Wintergerst, Joe; Adams, Larry; Mallioux, Joe; Denis, Rob; White, Karen; Long, Mark; Munshi, Naseem A.; Gall, Ken

    2005-05-01

    The use of smart materials and multifunctional components has the potential to provide enhanced performance, improved economics, and reduced safety concerns for applications ranging from outer space to subterranean. Elastic Memory Composite (EMC) materials, based on shape memory polymers and used to produce multifunctional components and structures, are being developed and qualified for commercial use as deployable components and structures. EMC materials are similar to traditional fiber-reinforced composites except for the use of a thermoset shape memory resin that enables much higher packaging strains than traditional composites without damage to the fibers or the resin. This unique capability is being exploited in the development of very efficient EMC structural components for deployable spacecraft systems as well as capability enhancing components for use in other industries. The present paper is intended primarily to describe the transition of EMC materials as smart structure technologies into viable industrial and commercial products. Specifically, the paper discusses: 1) TEMBO EMC materials for deployable space/aerospace systems, 2) TEMBO EMC resins for terrestrial applications, 3) future generation EMC materials.

  8. How Close We Are to Achieving Commercially Viable Large-Scale Photobiological Hydrogen Production by Cyanobacteria: A Review of the Biological Aspects

    PubMed Central

    Sakurai, Hidehiro; Masukawa, Hajime; Kitashima, Masaharu; Inoue, Kazuhito

    2015-01-01

    Photobiological production of H2 by cyanobacteria is considered to be an ideal source of renewable energy because the inputs, water and sunlight, are abundant. The products of photobiological systems are H2 and O2; the H2 can be used as the energy source of fuel cells, etc., which generate electricity at high efficiencies and minimal pollution, as the waste product is H2O. Overall, production of commercially viable algal fuels in any form, including biomass and biodiesel, is challenging, and the very few systems that are operational have yet to be evaluated. In this paper we will: briefly review some of the necessary conditions for economical production, summarize the reports of photobiological H2 production by cyanobacteria, present our schemes for future production, and discuss the necessity for further progress in the research needed to achieve commercially viable large-scale H2 production. PMID:25793279

  9. Commercial applications

    NASA Technical Reports Server (NTRS)

    Togai, Masaki

    1990-01-01

    Viewgraphs on commercial applications of fuzzy logic in Japan are presented. Topics covered include: suitable application area of fuzzy theory; characteristics of fuzzy control; fuzzy closed-loop controller; Mitsubishi heavy air conditioner; predictive fuzzy control; the Sendai subway system; automatic transmission; fuzzy logic-based command system for antilock braking system; fuzzy feed-forward controller; and fuzzy auto-tuning system.

  10. Polymerase chain reaction-based discrimination of viable from non-viable Mycoplasma gallisepticum.

    PubMed

    Tan, Ching Giap; Ideris, Aini; Omar, Abdul R; Yii, Chen Pei; Kleven, Stanley H

    2014-09-02

    The present study was based on the reverse transcription polymerase chain reaction (RT-PCR) of the 16S ribosomal nucleic acid (rRNA) of Mycoplasma for detection of viable Mycoplasma gallisepticum. To determine the stability of M. gallisepticum 16S rRNA in vitro, three inactivation methods were used and the suspensions were stored at different temperatures. The 16S rRNA of M. gallisepticum was detected up to approximately 20-25 h at 37 °C, 22-25 h at 16 °C, and 23-27 h at 4 °C. The test, therefore, could detect viable or recently dead M. gallisepticum (< 20 h). The RT-PCR method was applied during an in vivo study of drug efficacy under experimental conditions, where commercial broiler-breeder eggs were inoculated with M. gallisepticum into the yolk. Hatched chicks that had been inoculated in ovo were treated with Macrolide 1. The method was then applied in a flock of day 0 chicks with naturally acquired vertical transmission of M. gallisepticum, treated with Macrolide 2. Swabs of the respiratory tract were obtained for PCR and RT-PCR evaluations to determine the viability of M. gallisepticum. This study proved that the combination of both PCR and RT-PCR enables detection and differentiation of viable from non-viable M. gallisepticum.

  11. From the lab to commercial reality with biobased adhesives for wood

    Treesearch

    Charles R. Frihart; Michael J. Birkeland

    2016-01-01

    Many technologies can be demonstrated in the laboratory to give products that meet performance standards, but there are many hurdles to overcome before these products are commercially viable. Demonstrating performance under simulated commercial processes conditions is the first key step to be accomplished through using appropriate adhesive application, furnish...

  12. ARPA-E: Guiding Technologies to Commercial Success

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Tuttle, John; Aizenberg, Joanna; Madrone, Leila

    ARPA-E’s Technology-to-Market Advisors work closely with each ARPA-E project team to develop and execute a commercialization strategy. ARPA-E requires our teams to focus on their commercial path forward, because we understand that to have an impact on our energy mission, technologies must have a viable path into the marketplace. ARPA-E Senior Commercialization Advisor Dr. John Tuttle discusses what this Tech-to-Market guidance in practice looks like with reference to two project teams. OPEN 2012 awardees from Harvard University and Sunfolding share their stories of how ARPA-E worked with their teams to analyze market conditions and identify commercial opportunities that ultimately convincedmore » them to pivot their technologies towards market applications with greater potential.« less

  13. Sycamore produces viable seed after six years

    Treesearch

    A. F. Ike

    1966-01-01

    In the early stages of any tree improvement program it is desirable to know how soon progenies of selected parents can themselves be included in a breeding program. How soon will they produce viable pollen and seed? In the case of sycamore (Platanus occidentalis L.), the information is meager: the Woody- Plant Seed Manual lists the minimum commercial seedbearing age...

  14. Commercialization of New Beam Applications

    NASA Astrophysics Data System (ADS)

    McKeown, Joseph

    1996-05-01

    The commercialization of electron processing applications is driven by demonstrated technical advantages over current practice. Mature and reliable accelerator technology has permitted more consistent product quality and the development of new processes. However, the barriers to commercial adoption are often not amenable to solution within the laboratory alone. Aspects of the base accelerator technology, plant engineering, production, project management, financing, regulatory control, product throughput and plant operational efficiency all contribute to the business risk. Experiences in building three 10 MeV, 50 kW, IMPELA electron accelerators at approximately 8 M each and achieving cumulative operational availability greater than 98% in commercial environments have identified key parameters defining those aspects. The allowed ranges of these parameters to generate the 1.5 M annual revenue that is typically necessary to support outlays of this scale are presented. Such data have been used in proposals to displace expensive chemicals in the viscose industry, sterilize sewage sludge, detoxify chemically contaminated soils and build radiation service centers for a diversity of applications. The proposals face stiff competition from traditional chemical methods. Quantitative technical and business details of these activities are provided and an attempt is made to establish realistic expectations for the exploitation of electron beam technologies in emerging applications.

  15. Non-viable antagonist cells are associated with reduced biocontrol performance by viable cells of the yeast Papiliotrema flavescens against Fusarium head blight of wheat.

    USDA-ARS?s Scientific Manuscript database

    Microbially-based plant disease control products have achieved commercial market success, but the efficacy of such biocontrol products is sometimes deemed inconsistent. Improper processing of harvested microbial biomass or long-term storage can reduce the proportion of viable cells and necessitate t...

  16. Progress in biocatalysis with immobilized viable whole cells: systems development, reaction engineering and applications.

    PubMed

    Polakovič, Milan; Švitel, Juraj; Bučko, Marek; Filip, Jaroslav; Neděla, Vilém; Ansorge-Schumacher, Marion B; Gemeiner, Peter

    2017-05-01

    Viable microbial cells are important biocatalysts in the production of fine chemicals and biofuels, in environmental applications and also in emerging applications such as biosensors or medicine. Their increasing significance is driven mainly by the intensive development of high performance recombinant strains supplying multienzyme cascade reaction pathways, and by advances in preservation of the native state and stability of whole-cell biocatalysts throughout their application. In many cases, the stability and performance of whole-cell biocatalysts can be highly improved by controlled immobilization techniques. This review summarizes the current progress in the development of immobilized whole-cell biocatalysts, the immobilization methods as well as in the bioreaction engineering aspects and economical aspects of their biocatalytic applications.

  17. Commercial Pesticides Applicator Manual: Agriculture - Plant.

    ERIC Educational Resources Information Center

    Fitzwater, W. D.; And Others

    This training manual provides information needed to meet the minimum EPA standards for certification as a commercial applicator of pesticides in the agriculture-plant pest control category. The text discusses identification and control of insects, diseases, nematodes, and weeds of agricultural crops. Proper use of application equipment and safety…

  18. Optical intersatellite links - Application to commercial satellite communications

    NASA Technical Reports Server (NTRS)

    Paul, D.; Faris, F.; Garlow, R.; Inukai, T.; Pontano, B.; Razdan, R.; Ganz, Aura; Caudill, L.

    1992-01-01

    Application of optical intersatellite links for commercial satellite communications services is addressed in this paper. The feasibility of commercialization centers around basic issues such as the need and derived benefits, implementation complexity and overall cost. In this paper, commercialization of optical ISLs is assessed in terms of the services provided, systems requirements and feasibility of appropriate technology. Both long- and short-range ISLs for GEO-GEO, GEO-LEO and LEO applications are considered. Impact of systems requirements on the payload design and use of advanced technology in reducing its mass, power, and volume requirements are discussed.

  19. Process to Selectively Distinguish Viable from Non-Viable Bacterial Cells

    NASA Technical Reports Server (NTRS)

    LaDuc, Myron T.; Bernardini, Jame N.; Stam, Christina N.

    2010-01-01

    The combination of ethidium monoazide (EMA) and post-fragmentation, randomly primed DNA amplification technologies will enhance the analytical capability to discern viable from non-viable bacterial cells in spacecraft-related samples. Intercalating agents have been widely used since the inception of molecular biology to stain and visualize nucleic acids. Only recently, intercalating agents such as EMA have been exploited to selectively distinguish viable from dead bacterial cells. Intercalating dyes can only penetrate the membranes of dead cells. Once through the membrane and actually inside the cell, they intercalate DNA and, upon photolysis with visible light, produce stable DNA monoadducts. Once the DNA is crosslinked, it becomes insoluble and unable to be fragmented for post-fragmentation, randomly primed DNA library formation. Viable organisms DNA remains unaffected by the intercalating agents, allowing for amplification via post-fragmentation, randomly primed technologies. This results in the ability to carry out downstream nucleic acid-based analyses on viable microbes to the exclusion of all non-viable cells.

  20. Dye Sensitized Solar Cells for Economically Viable Photovoltaic Systems.

    PubMed

    Jung, Hyun Suk; Lee, Jung-Kun

    2013-05-16

    TiO2 nanoparticle-based dye sensitized solar cells (DSSCs) have attracted a significant level of scientific and technological interest for their potential as economically viable photovoltaic devices. While DSSCs have multiple benefits such as material abundance, a short energy payback period, constant power output, and compatibility with flexible applications, there are still several challenges that hold back large scale commercialization. Critical factors determining the future of DSSCs involve energy conversion efficiency, long-term stability, and production cost. Continuous advancement of their long-term stability suggests that state-of-the-art DSSCs will operate for over 20 years without a significant decrease in performance. Nevertheless, key questions remain in regards to energy conversion efficiency improvements and material cost reduction. In this Perspective, the present state of the field and the ongoing efforts to address the requirements of DSSCs are summarized with views on the future of DSSCs.

  1. [Quality of commercial inoculants for soybean crop in Argentina: concentration of viable rhizobia and presence of contaminants].

    PubMed

    Benintende, S

    2010-01-01

    In view of the inoculant production technology available, quality control is a necessary tool to improve soybean inoculants commercialized in Argentina. In 1988, the Facultad de Ciencias Agropecuarias de la Universidad Nacional de Entre Ríos (Argentina) created a quality control service for soybean crop inoculants to offer to farmers. The aim of this study was to evaluate the quality of soybean crop inoculants for seven cropping seasons and to contrast these results with those from previous investigations conducted in our country. This work was developed using 128 inoculant samples from 30 different trade names. The analyzed variables were: inoculant label information, number of viable rhizobia and presence of contaminants. Twenty per cent of the labels showed defects that did not comply with the Argentine legislation. The detected problems in inoculant labels were related to lot numbers or the expiry date, which lacked, was easy to remove or not visible. Eighty seven per cent of the analyzed inoculants were formulated in liquid carriers. Seventy six per cent of the samples had a number of rhizobia above 10(8) CFU/g or ml, the minimum quantity required by the legislation. Thirty per cent of the analyzed inoculants had contaminants and their presence was related to low rhizobia counts, as shown in a correspondence analysis. The relationship between liquid inoculants and the absence of contaminants was expressed. It can be concluded from the comparison of results found in this investigation with those in previous works published on Argentinean inoculants, that inoculant quality has been improved, although the situation is far from ideal. Adequate manufacturing and commercialization controls are necessary to ensure product quality.

  2. Carbon Nanotubes: Present and Future Commercial Applications

    NASA Astrophysics Data System (ADS)

    De Volder, Michael F. L.; Tawfick, Sameh H.; Baughman, Ray H.; Hart, A. John

    2013-02-01

    Worldwide commercial interest in carbon nanotubes (CNTs) is reflected in a production capacity that presently exceeds several thousand tons per year. Currently, bulk CNT powders are incorporated in diverse commercial products ranging from rechargeable batteries, automotive parts, and sporting goods to boat hulls and water filters. Advances in CNT synthesis, purification, and chemical modification are enabling integration of CNTs in thin-film electronics and large-area coatings. Although not yet providing compelling mechanical strength or electrical or thermal conductivities for many applications, CNT yarns and sheets already have promising performance for applications including supercapacitors, actuators, and lightweight electromagnetic shields.

  3. Carbon nanotubes: present and future commercial applications.

    PubMed

    De Volder, Michael F L; Tawfick, Sameh H; Baughman, Ray H; Hart, A John

    2013-02-01

    Worldwide commercial interest in carbon nanotubes (CNTs) is reflected in a production capacity that presently exceeds several thousand tons per year. Currently, bulk CNT powders are incorporated in diverse commercial products ranging from rechargeable batteries, automotive parts, and sporting goods to boat hulls and water filters. Advances in CNT synthesis, purification, and chemical modification are enabling integration of CNTs in thin-film electronics and large-area coatings. Although not yet providing compelling mechanical strength or electrical or thermal conductivities for many applications, CNT yarns and sheets already have promising performance for applications including supercapacitors, actuators, and lightweight electromagnetic shields.

  4. Space Biotechnology and Commercial Applications University of Florida

    NASA Technical Reports Server (NTRS)

    Phillips, Winfred; Evanich, Peggy L.

    2004-01-01

    The Space Biotechnology and Commercial Applications grant was funded by NASA's Kennedy Space Center in FY 2002 to provide dedicated biotechnology and agricultural research focused on the regeneration of space flight environments with direct parallels in Earth-based applications for solving problems in the environment, advances in agricultural science, and other human support issues amenable to targeted biotechnology solutions. This grant had three project areas, each with multiple tasks. They are: 1) Space Agriculture and Biotechnology Research and Education, 2) Integrated Smart Nanosensors for Space Biotechnology Applications, and 3) Commercial Applications. The Space Agriculture and Biotechnology Research and Education (SABRE) Center emphasized the fundamental biology of organisms involved in space flight applications, including those involved in advanced life support environments because of their critical role in the long-term exploration of space. The SABRE Center supports research at the University of Florida and at the Space Life Sciences Laboratory (SLSL) at the Kennedy Space Center. The Integrated Smart Nanosensors for Space Biotechnology Applications component focused on developing and applying sensor technologies to space environments and agricultural systems. The research activities in nanosensors were coordinated with the SABRE portions of this grant and with the research sponsored by the NASA Environmental Systems Commercial Space Technology Center located in the Department of Environmental Engineering Sciences. Initial sensor efforts have focused on air and water quality monitoring essential to humans for living and working permanently in space, an important goal identified in NASA's strategic plan. The closed environment of a spacecraft or planetary base accentuates cause and effect relationships and environmental impacts. The limited available air and water resources emphasize the need for reuse, recycling, and system monitoring. It is essential to

  5. Commercial aerospace and terrestrial applications of nickel-hydrogen batteries

    NASA Astrophysics Data System (ADS)

    Caldwell, Dwight B.; Coates, Dwaine K.; Fox, Chris L.; Miller, Lee E.

    1996-03-01

    The nickel-hydrogen battery system, used extensively in the aerospace industry to supply electrical power to earth-orbital satellites for communications, observation, and military applications, is being developed for commercial, terrestrial applications. Low-cost components, electrodes, cell designs, and battery designs are currently being tested. Catalytic hydrogen electrodes have been developed which are compatible with commercial nickel battery cost. Prismatic and spiral-wound cell designs have been built and tested. Common pressure vessel and dependent pressure vessel battery designs are also being evaluated. The nickel-hydrogen battery offers potential cycle life unequaled by any other battery system. This makes the battery ideal for many commercial and terrestrial energy storage applications such as telecommunication, remote stand-alone power systems, utility load-leveling, and other applications which require long life and a truly maintenance-free and abuse-tolerant battery system.

  6. Is self-sufficiency financially viable and ethically justifiable?--a commercial viewpoint.

    PubMed

    Christie, R B

    1994-12-01

    Manufacturers of blood products have to maintain the highest possible standards for plasma screening and good manufacturing practices to ensure maximum purity and viral safety. The private sector companies have much experience in implementing and complying with national and international regulations. These requirements involve considerable cost in the areas of (1) plasma collection facilities, (2) research and clinical research, (3) manufacture, and (4) quality control. Total self-sufficiency would mean the loss of many existing resources. An alternative would be a collaboration between the public and private sectors to meet the needs of all patients who require plasma derived products. The current definition of self-sufficiency suggests that it is not financially viable.

  7. NASA's Earth Observations Commercialization Applications Program: A model for government promotion of commercial space opportunities

    NASA Technical Reports Server (NTRS)

    Macauley, Molly K.

    1995-01-01

    The role of government in promoting space commerce is a topic of discussion in every spacefaring nation. This article describes a new approach to government intervention which, based on its five-year track record, appears to have met with success. The approach, developed in NASA's Earth Observations Commercialization Application Program (EOCAP), offer several lessons for effective government sponsorship of commercial space development in general and of commercial remote sensing in particular.

  8. Safe, Effective Use of Pesticides: A Manual for Commercial Applicators.

    ERIC Educational Resources Information Center

    Extension Service (USDA), Washington, DC.

    This publication is a certification manual for the commercial pesticide applicator's permit of the Michigan Department of Agriculture. The information presented in this manual is designed to assist prospective commercial pesticide applicators to meet certification requirements under federal guidelines. The first of the eight sections deals with…

  9. Commercial Applications Multispectral Sensor System

    NASA Technical Reports Server (NTRS)

    Birk, Ronald J.; Spiering, Bruce

    1993-01-01

    NASA's Office of Commercial Programs is funding a multispectral sensor system to be used in the development of remote sensing applications. The Airborne Terrestrial Applications Sensor (ATLAS) is designed to provide versatility in acquiring spectral and spatial information. The ATLAS system will be a test bed for the development of specifications for airborne and spaceborne remote sensing instrumentation for dedicated applications. This objective requires spectral coverage from the visible through thermal infrared wavelengths, variable spatial resolution from 2-25 meters; high geometric and geo-location accuracy; on-board radiometric calibration; digital recording; and optimized performance for minimized cost, size, and weight. ATLAS is scheduled to be available in 3rd quarter 1992 for acquisition of data for applications such as environmental monitoring, facilities management, geographic information systems data base development, and mineral exploration.

  10. Layered Thermal Insulation Systems for Industrial and Commercial Applications

    NASA Technical Reports Server (NTRS)

    Fesmire, James E.

    2015-01-01

    From the high performance arena of cryogenic equipment, several different layered thermal insulation systems have been developed for industrial and commercial applications. In addition to the proven areas in cold-work applications for piping and tanks, the new Layered Composite Insulation for Extreme Environments (LCX) has potential for broader industrial use as well as for commercial applications. The LCX technology provides a unique combination of thermal, mechanical, and weathering performance capability that is both cost-effective and enabling. Industry applications may include, for example, liquid nitrogen (LN2) systems for food processing, liquefied natural gas (LNG) systems for transportation or power, and chilled water cooling facilities. Example commercial applications may include commercial residential building construction, hot water piping, HVAC systems, refrigerated trucks, cold chain shipping containers, and a various consumer products. The LCX system is highly tailorable to the end-use application and can be pre-fabricated or field assembled as needed. Product forms of LCX include rigid sheets, semi-flexible sheets, cylindrical clam-shells, removable covers, or flexible strips for wrapping. With increasing system control and reliability requirements as well as demands for higher energy efficiencies, thermal insulation in harsh environments is a growing challenge. The LCX technology grew out of solving problems in the insulation of mechanically complex cryogenic systems that must operate in outdoor, humid conditions. Insulation for cold work includes equipment for everything from liquid helium to chilled water. And in the middle are systems for LNG, LN2, liquid oxygen (LO2), liquid hydrogen (LH2) that must operate in the ambient environment. Different LCX systems have been demonstrated for sub-ambient conditions but are capable of moderately high temperature applications as well.

  11. Commercial Pesticides Applicator Manual: Public Health.

    ERIC Educational Resources Information Center

    Fitzwater, William D.; Reed, Leonard G., Jr.

    This training manual provides information needed to meet the minimum EPA standards for certification as a commercial applicator of pesticides in the public health pest control category. The text discusses pests such as roaches, bedbugs, bees, mosquitoes, gnats, flies, and rodents with possible control measures provided. (CS)

  12. Airborne Remote Sensing (ARS) for Agricultural Research and Commercialization Applications

    NASA Technical Reports Server (NTRS)

    Narayanan, Ram; Bowen, Brent D.; Nickerson, Jocelyn S.

    2002-01-01

    Tremendous advances in remote sensing technology and computing power over the last few decades are now providing scientists with the opportunity to investigate, measure, and model environmental patterns and processes with increasing confidence. Such advances are being pursued by the Nebraska Remote Sensing Facility, which consists of approximately 30 faculty members and is very competitive with other institutions in the depth of the work that is accomplished. The development of this facility targeted at applications, commercialization, and education programs in the area of precision agriculture provides a unique opportunity. This critical area is within the scope of NASA goals and objectives of NASA s Applications, Technology Transfer, Commercialization, and Education Division and the Earth Science Enterprise. This innovative integration of Aerospace (Aeronautics) Technology Enterprise applications with other NASA enterprises serves as a model of cross-enterprise transfer of science with specific commercial applications.

  13. Aerospace management techniques: Commercial and governmental applications

    NASA Technical Reports Server (NTRS)

    Milliken, J. G.; Morrison, E. J.

    1971-01-01

    A guidebook for managers and administrators is presented as a source of useful information on new management methods in business, industry, and government. The major topics discussed include: actual and potential applications of aerospace management techniques to commercial and governmental organizations; aerospace management techniques and their use within the aerospace sector; and the aerospace sector's application of innovative management techniques.

  14. 47 CFR 73.4017 - Application processing: Commercial FM stations.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 47 Telecommunication 4 2010-10-01 2010-10-01 false Application processing: Commercial FM stations. 73.4017 Section 73.4017 Telecommunication FEDERAL COMMUNICATIONS COMMISSION (CONTINUED) BROADCAST... processing: Commercial FM stations. See Report and Order, MM Docket 84-750, FCC 85-125, adopted March 4, 1985...

  15. 47 CFR 73.4017 - Application processing: Commercial FM stations.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 47 Telecommunication 4 2011-10-01 2011-10-01 false Application processing: Commercial FM stations. 73.4017 Section 73.4017 Telecommunication FEDERAL COMMUNICATIONS COMMISSION (CONTINUED) BROADCAST... processing: Commercial FM stations. See Report and Order, MM Docket 84-750, FCC 85-125, adopted March 4, 1985...

  16. Apply Pesticides Correctly: A Guide for Commercial Applicators.

    ERIC Educational Resources Information Center

    Environmental Protection Agency, Washington, DC.

    This document provides practical information needed by commercial pesticide applicators to meet the minimum Federal regulation requirements for the use of various pesticides. The text and accompanying illustrations cover the seven major topics of pests, pest control, pesticides, labels and labeling, using pesticides safely, application equipment,…

  17. Challenges of International Programs in Commercial Wireless Power Trasmission

    NASA Technical Reports Server (NTRS)

    Dickinson, Richard M.

    1993-01-01

    The proposition is offered that only by forming international alliances will econmically viable commercial wireless poer transmission (WPT) result. Radio emissions from commercial WPT will likely extend beyond the borders of a single nation.

  18. Power system requirements and concepts for a commercially viable lunar base architecture

    NASA Astrophysics Data System (ADS)

    Lenard, Roger X.; Binder, Alan B.

    1999-01-01

    Historically, space exploration has been the province of governments and major agencies within those governmental entities. Recent advances in the state-of-the-art in many subsystem technology areas and the revealed inadequacies of governments to singlehandedly underwrite major exploration ventures present the potential to expand the venue of space exploration to the commercial sector. Further, major international projects such as the International Space Station have revealed weaknesses in both international financing and management of such projects. Cost overruns are the rule and significant schedule slips and/or failures to deliver have resulted in an enormously costly and delayed program. The exorbitant costs have stymied exploration ventures beyond Earth orbit. There are many potential advantages to a commercial operation including cost, schedule and a distinct customer orientation to services. The objective of this paper is to describe the first phase of a phased strawman commercial lunar base concept which operates as a user facility for governmental entities, corporations and companies. The paper will discuss the power system options and conditions under which such a base can be made to become profitable.

  19. Number of viable bacteria and presumptive antibiotic residues in milk fed to calves on commercial dairies.

    PubMed

    Selim, S A; Cullor, J S

    1997-10-15

    To assess the number of bacteria and presumptive antibiotic residues in milk fed to calves and to identify those bacteria and the antibiotic susceptibility of selected bacterial strains. Cross-sectional prospective study. 189 samples obtained from 12 local dairies. Samples of waste milk and milk-based fluids (eg, milk replacer, colostrum, bulk-tank milk) were obtained. Cumulative number of viable bacteria was determined. Bacteria were cultured aerobically, and antibiotic susceptibility testing of selected strains was performed. Presumptive antibiotic residues were detected by use of test kits. Geometric mean of the cumulative number of bacteria for waste milk samples was significantly higher than for other types of milk or milk-based products. Streptococcus sp (84/165 samples) and Enterobacteriaceae (83/165 samples) were the predominant bacteria identified, followed by Staphylococcus sp (68/165 samples). Escherichia coli was the gram-negative species most commonly isolated (52/165 samples; 32%); however, none were strain O157. Salmonella sp or Mycoplasma sp were not isolated. Of 189 samples, 119 (63%) were positive when tested for beta-lactams or tetracycline by use of 2 commercially available assays. In vitro, some bacteria were resistant to commonly used antibiotics. Waste milk that has not been effectively treated (eg, pasteurization) to reduce microbial load prior to use as calf feed should be used with caution, because it may contain a high number of bacteria that may be pathogenic to cattle and human beings. Antibiotic residues that would constitute violative amounts and existence of multiple antibiotic resistant bacterial strains are concerns in calf health management and dairy food safety.

  20. Human error analysis of commercial aviation accidents: application of the Human Factors Analysis and Classification system (HFACS).

    PubMed

    Wiegmann, D A; Shappell, S A

    2001-11-01

    The Human Factors Analysis and Classification System (HFACS) is a general human error framework originally developed and tested within the U.S. military as a tool for investigating and analyzing the human causes of aviation accidents. Based on Reason's (1990) model of latent and active failures, HFACS addresses human error at all levels of the system, including the condition of aircrew and organizational factors. The purpose of the present study was to assess the utility of the HFACS framework as an error analysis and classification tool outside the military. The HFACS framework was used to analyze human error data associated with aircrew-related commercial aviation accidents that occurred between January 1990 and December 1996 using database records maintained by the NTSB and the FAA. Investigators were able to reliably accommodate all the human causal factors associated with the commercial aviation accidents examined in this study using the HFACS system. In addition, the classification of data using HFACS highlighted several critical safety issues in need of intervention research. These results demonstrate that the HFACS framework can be a viable tool for use within the civil aviation arena. However, additional research is needed to examine its applicability to areas outside the flight deck, such as aircraft maintenance and air traffic control domains.

  1. From Prototype to Product: Making Participatory Design of mHealth Commercially Viable.

    PubMed

    Andersen, Tariq O; Bansler, Jørgen P; Kensing, Finn; Moll, Jonas

    2017-01-01

    This paper delves into the challenges of engaging patients, clinicians and industry stakeholders in the participatory design of an mHealth platform for patient-clinician collaboration. It follows the process from the development of a research prototype to a commercial software product. In particular, we draw attention to four major challenges of (a) aligning the different concerns of patients and clinicians, (b) designing according to clinical accountability, (c) ensuring commercial interest, and (d) dealing with regulatory constraints when prototyping safety critical health Information Technology. Using four illustrative cases, we discuss what these challenges entail and the implications they pose to Participatory Design. We conclude the paper by presenting lessons learned.

  2. 47 CFR 0.483 - Applications for amateur or commercial radio operator licenses.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 47 Telecommunication 1 2010-10-01 2010-10-01 false Applications for amateur or commercial radio operator licenses. 0.483 Section 0.483 Telecommunication FEDERAL COMMUNICATIONS COMMISSION GENERAL..., and for Taking Examinations § 0.483 Applications for amateur or commercial radio operator licenses. (a...

  3. A global reference database from very high resolution commercial satellite data and methodology for application to Landsat derived 30 m continuous field tree cover data

    USGS Publications Warehouse

    Pengra, Bruce; Long, Jordan; Dahal, Devendra; Stehman, Stephen V.; Loveland, Thomas R.

    2015-01-01

    The methodology for selection, creation, and application of a global remote sensing validation dataset using high resolution commercial satellite data is presented. High resolution data are obtained for a stratified random sample of 500 primary sampling units (5 km  ×  5 km sample blocks), where the stratification based on Köppen climate classes is used to distribute the sample globally among biomes. The high resolution data are classified to categorical land cover maps using an analyst mediated classification workflow. Our initial application of these data is to evaluate a global 30 m Landsat-derived, continuous field tree cover product. For this application, the categorical reference classification produced at 2 m resolution is converted to percent tree cover per 30 m pixel (secondary sampling unit)for comparison to Landsat-derived estimates of tree cover. We provide example results (based on a subsample of 25 sample blocks in South America) illustrating basic analyses of agreement that can be produced from these reference data. Commercial high resolution data availability and data quality are shown to provide a viable means of validating continuous field tree cover. When completed, the reference classifications for the full sample of 500 blocks will be released for public use.

  4. Advanced thermal control technology for commercial applications

    NASA Technical Reports Server (NTRS)

    Swanson, Theodore D.

    1991-01-01

    A number of the technologies previously developed for the thermal control of spacecraft have found their way into commercial application. Specialized coatings and heat pipes are but two examples. The thermal control of current and future spacecraft is becoming increasingly more demanding, and a variety of new technologies are being developed to meet these needs. Closed two-phase loops are perceived to be the answer to many of the new requirements. All of these technologies are discussed, and their spacecraft and current terrestrial applications are summarized.

  5. 40 CFR 457.10 - Applicability; description of the commercial manufacture of explosives subcategory.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... commercial manufacture of explosives subcategory. 457.10 Section 457.10 Protection of Environment... SOURCE CATEGORY Manufacture of Explosives Subcategory § 457.10 Applicability; description of the commercial manufacture of explosives subcategory. The provisions of this subpart are applicable to discharges...

  6. Commercial Off-The-Shelf (COTS) Electronics Reliability for Space Applications

    NASA Technical Reports Server (NTRS)

    Pellish, Jonathan

    2018-01-01

    This presentation describes the accelerating use of Commercial off the Shelf (COTS) parts in space applications. Component reliability and threats in the context of the mission, environment, application, and lifetime. Provides overview of traditional approaches applied to COTS parts in flight applications, and shows challenges and potential paths forward for COTS systems in flight applications it's all about data!

  7. NASA Technology Applications Team: Commercial applications of aerospace technology

    NASA Technical Reports Server (NTRS)

    1994-01-01

    The Research Triangle Institute (RTI) is pleased to report the results of NASA contract NASW-4367, 'Operation of a Technology Applications Team'. Through a period of significant change within NASA, the RTI Team has maintained its focus on helping NASA establish partnerships with U.S. industry for dual use development and technology commercialization. Our emphasis has been on outcomes, such as licenses, industry partnerships and commercialization of technologies that are important to NASA in its mission of contributing to the improved competitive position of U.S. industry. RTI's ongoing commitment to quality and customer responsiveness has driven our staff to continuously improve our technology transfer methodologies to meet NASA's requirements. For example, RTI has emphasized the following areas: (1) Methodology For Technology Assessment and Marketing: RTI has developed an implemented effective processes for assessing the commercial potential of NASA technologies. These processes resulted from an RTI study of best practices, hands-on experience, and extensive interaction with the NASA Field Centers to adapt to their specific needs; (2) Effective Marketing Strategies: RTI surveyed industry technology managers to determine effective marketing tools and strategies. The Technology Opportunity Announcement format and content were developed as a result of this industry input. For technologies with a dynamic visual impact, RTI has developed a stand-alone demonstration diskette that was successful in developing industry interest in licensing the technology; and (3) Responsiveness to NASA Requirements: RTI listened to our customer (NASA) and designed our processes to conform with the internal procedures and resources at each NASA Field Center and the direction provided by NASA's Agenda for Change. This report covers the activities of the Research Triangle Institute Technology Applications Team for the period 1 October 1993 through 31 December 1994.

  8. Commercial grade item (CGI) dedication of generators for nuclear safety related applications

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Das, R.K.; Hajos, L.G.

    1993-03-01

    The number of nuclear safety related equipment suppliers and the availability of spare and replacement parts designed specifically for nuclear safety related application are shrinking rapidly. These have made it necessary for utilities to apply commercial grade spare and replacement parts in nuclear safety related applications after implementing proper acceptance and dedication process to verify that such items conform with the requirements of their use in nuclear safety related application. The general guidelines for the commercial grade item (CGI) acceptance and dedication are provided in US Nuclear Regulatory Commission (NRC) Generic Letters and Electric Power Research Institute (EPRI) Report NP-5652,more » Guideline for the Utilization of Commercial Grade Items in Nuclear Safety Related Applications. This paper presents an application of these generic guidelines for procurement, acceptance, and dedication of a commercial grade generator for use as a standby generator at Salem Generating Station Units 1 and 2. The paper identifies the critical characteristics of the generator which once verified, will provide reasonable assurance that the generator will perform its intended safety function. The paper also delineates the method of verification of the critical characteristics through tests and provide acceptance criteria for the test results. The methodology presented in this paper may be used as specific guidelines for reliable and cost effective procurement and dedication of commercial grade generators for use as standby generators at nuclear power plants.« less

  9. Lawn and Turf Pest Control: A Guide for Commercial Applicators.

    ERIC Educational Resources Information Center

    Khan, M. S.

    This manual is designed for use in training commercial pesticide applicators. It gives identification and control information for common lawn and turf diseases, insects, nematodes, weeds, and vertebrate pests. It also discusses phytotoxicity, environmental concerns, and application methods. (BB)

  10. Fluorogenic Substrate Detection of Viable Intracellular and Extracellular Pathogenic Protozoa

    NASA Astrophysics Data System (ADS)

    Jackson, Peter R.; Pappas, Michael G.; Hansen, Brian D.

    1985-01-01

    Viable Leishmania promastigotes and amastigotes were detected by epifluorescence microscopy with fluorescein diacetate being used to mark living parasites and the nucleic acid-binding compound ethidium bromide to stain dead cells. This procedure is superior to other assays because it is faster and detects viable intracellular as well as extracellular Leishmania. Furthermore, destruction of intracellular pathogens by macrophages is more accurately determined with fluorescein diacetate than with other stains. The procedure may have applications in programs to develop drugs and vaccines against protozoa responsible for human and animal disease.

  11. 48 CFR 212.504 - Applicability of certain laws to subcontracts for the acquisition of commercial items.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... laws to subcontracts for the acquisition of commercial items. 212.504 Section 212.504 Federal... PLANNING ACQUISITION OF COMMERCIAL ITEMS Applicability of Certain Laws to the Acquisition of Commercial Items 212.504 Applicability of certain laws to subcontracts for the acquisition of commercial items. (a...

  12. 40 CFR 171.3 - Categorization of commercial applicators of pesticides.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... restricted use pesticides in public health programs for the management and control of pests having medical... applicators of pesticides. 171.3 Section 171.3 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) PESTICIDE PROGRAMS CERTIFICATION OF PESTICIDE APPLICATORS § 171.3 Categorization of commercial...

  13. 40 CFR 171.3 - Categorization of commercial applicators of pesticides.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... restricted use pesticides in public health programs for the management and control of pests having medical... applicators of pesticides. 171.3 Section 171.3 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) PESTICIDE PROGRAMS CERTIFICATION OF PESTICIDE APPLICATORS § 171.3 Categorization of commercial...

  14. 40 CFR 171.4 - Standards for certification of commercial applicators.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... (CONTINUED) PESTICIDE PROGRAMS CERTIFICATION OF PESTICIDE APPLICATORS § 171.4 Standards for certification of commercial applicators. (a) Determination of competency. Competence in the use and handling of pesticides... pesticides. Testing shall be based on examples of problems and situations appropriate to the particular...

  15. 40 CFR 171.3 - Categorization of commercial applicators of pesticides.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... restricted use pesticides in public health programs for the management and control of pests having medical... applicators of pesticides. 171.3 Section 171.3 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) PESTICIDE PROGRAMS CERTIFICATION OF PESTICIDE APPLICATORS § 171.3 Categorization of commercial...

  16. 40 CFR 171.4 - Standards for certification of commercial applicators.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... (CONTINUED) PESTICIDE PROGRAMS CERTIFICATION OF PESTICIDE APPLICATORS § 171.4 Standards for certification of commercial applicators. (a) Determination of competency. Competence in the use and handling of pesticides... pesticides. Testing shall be based on examples of problems and situations appropriate to the particular...

  17. 40 CFR 171.4 - Standards for certification of commercial applicators.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... (CONTINUED) PESTICIDE PROGRAMS CERTIFICATION OF PESTICIDE APPLICATORS § 171.4 Standards for certification of commercial applicators. (a) Determination of competency. Competence in the use and handling of pesticides... pesticides. Testing shall be based on examples of problems and situations appropriate to the particular...

  18. 40 CFR 171.3 - Categorization of commercial applicators of pesticides.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... restricted use pesticides in public health programs for the management and control of pests having medical... applicators of pesticides. 171.3 Section 171.3 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) PESTICIDE PROGRAMS CERTIFICATION OF PESTICIDE APPLICATORS § 171.3 Categorization of commercial...

  19. 40 CFR 171.4 - Standards for certification of commercial applicators.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... (CONTINUED) PESTICIDE PROGRAMS CERTIFICATION OF PESTICIDE APPLICATORS § 171.4 Standards for certification of commercial applicators. (a) Determination of competency. Competence in the use and handling of pesticides... pesticides. Testing shall be based on examples of problems and situations appropriate to the particular...

  20. 40 CFR 171.3 - Categorization of commercial applicators of pesticides.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... restricted use pesticides in public health programs for the management and control of pests having medical... applicators of pesticides. 171.3 Section 171.3 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) PESTICIDE PROGRAMS CERTIFICATION OF PESTICIDE APPLICATORS § 171.3 Categorization of commercial...

  1. 40 CFR 171.4 - Standards for certification of commercial applicators.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... (CONTINUED) PESTICIDE PROGRAMS CERTIFICATION OF PESTICIDE APPLICATORS § 171.4 Standards for certification of commercial applicators. (a) Determination of competency. Competence in the use and handling of pesticides... pesticides. Testing shall be based on examples of problems and situations appropriate to the particular...

  2. Robust Low-Cost Cathode for Commercial Applications

    NASA Technical Reports Server (NTRS)

    Patterson, Michael J.

    2007-01-01

    Under funding from the NASA Commercial Technology Office, a cathode assembly was designed, developed, fabricated, and tested for use in plasma sources for ground-based materials processing applications. The cathode development activity relied on the large prior NASA investment and successful development of high-current, high-efficiency, long-life hollow cathodes for use on the International Space Station Plasma Contactor System. The hollow cathode was designed and fabricated based on known engineering criteria and manufacturing processes for compatibility with the requirements of the plasma source. The transfer of NASA GRC-developed hollow cathode technology for use as an electron emitter in the commercial plasma source is anticipated to yield a significant increase in process control, while eliminating the present issues of electron emitter lifetime and contamination.

  3. Application of adaptive antenna techniques to future commercial satellite communication

    NASA Technical Reports Server (NTRS)

    Ersoy, L.; Lee, E. A.; Matthews, E. W.

    1987-01-01

    The purpose of this contract was to identify the application of adaptive antenna technique in future operational commercial satellite communication systems and to quantify potential benefits. The contract consisted of two major subtasks. Task 1, Assessment of Future Commercial Satellite System Requirements, was generally referred to as the Adaptive section. Task 2 dealt with Pointing Error Compensation Study for a Multiple Scanning/Fixed Spot Beam Reflector Antenna System and was referred to as the reconfigurable system. Each of these tasks was further sub-divided into smaller subtasks. It should also be noted that the reconfigurable system is usually defined as an open-loop system while the adaptive system is a closed-loop system. The differences between the open- and closed-loop systems were defined. Both the adaptive and reconfigurable systems were explained and the potential applications of such systems were presented in the context of commercial communication satellite systems.

  4. 48 CFR 12.504 - Applicability of certain laws to subcontracts for the acquisition of commercial items.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... laws to subcontracts for the acquisition of commercial items. 12.504 Section 12.504 Federal Acquisition... Applicability of Certain Laws to the Acquisition of Commercial Items and Commercially Available Off-The-Shelf Items 12.504 Applicability of certain laws to subcontracts for the acquisition of commercial items. (a...

  5. ERAST: Scientific Applications and Technology Commercialization

    NASA Technical Reports Server (NTRS)

    Hunley, John D. (Compiler); Kellogg, Yvonne (Compiler)

    2000-01-01

    This is a conference publication for an event designed to inform potential contractors and appropriate personnel in various scientific disciplines that the ERAST (Environmental Research Aircraft and Sensor Technology) vehicles have reached a certain level of maturity and are available to perform a variety of missions ranging from data gathering to telecommunications. There are multiple applications of the technology and a great many potential commercial and governmental markets. As high altitude platforms, the ERAST vehicles can gather data at higher resolution than satellites and can do so continuously, whereas satellites pass over a particular area only once each orbit. Formal addresses are given by Rich Christiansen, (Director of Programs, NASA Aerospace Technology Ent.), Larry Roeder, (Senior Policy Advisor, U.S. Dept. of State), and Dr. Marianne McCarthy, (DFRC Education Dept.). The Commercialization Workshop is chaired by Dale Tietz (President, New Vista International) and the Science Workshop is chaired by Steve Wegener, (Deputy Manager of NASA ERAST, NASA Ames Research Center.

  6. Towards stable and commercially available perovskite solar cells

    DOE PAGES

    Park, Nam-Gyu; Grätzel, Michael; Miyasaka, Tsutomu; ...

    2016-10-17

    Solar cells employing a halide perovskite with an organic cation now show power conversion efficiency of up to 22%. But, these cells are facing issues towards commercialization, such as the need to achieve long-term stability and the development of a manufacturing method for the reproducible fabrication of high-performance devices. We propose a strategy to obtain stable and commercially viable perovskite solar cells. A reproducible manufacturing method is suggested, as well as routes to manage grain boundaries and interfacial charge transport. Electroluminescence is regarded as a metric to gauge theoretical efficiency. We highlight how optimizing the design of device architectures ismore » important not only for achieving high efficiency but also for hysteresis-free and stable performance. Here, we argue that reliable device characterization is needed to ensure the advance of this technology towards practical applications. We believe that perovskite-based devices can be competitive with silicon solar modules, and discuss issues related to the safe management of toxic material.« less

  7. NASA Technology Applications Team: Commercial applications of aerospace technology

    NASA Technical Reports Server (NTRS)

    1994-01-01

    The Research Triangle Institute (RTI) Team has maintained its focus on helping NASA establish partnerships with U.S. industry for dual use development and technology commercialization. Our emphasis has been on outcomes, such as licenses, industry partnerships and commercialization of technologies, that are important to NASA in its mission of contributing to the improved competitive position of U.S. industry. The RTI Team has been successful in the development of NASA/industry partnerships and commercialization of NASA technologies. RTI ongoing commitment to quality and customer responsiveness has driven our staff to continuously improve our technology transfer methodologies to meet NASA's requirements. For example, RTI has emphasized the following areas: (1) Methodology For Technology Assessment and Marketing: RTI has developed and implemented effective processes for assessing the commercial potential of NASA technologies. These processes resulted from an RTI study of best practices, hands-on experience, and extensive interaction with the NASA Field Centers to adapt to their specific needs. (2) Effective Marketing Strategies: RTI surveyed industry technology managers to determine effective marketing tools and strategies. The Technology Opportunity Announcement format and content were developed as a result of this industry input. For technologies with a dynamic visual impact, RTI has developed a stand-alone demonstration diskette that was successful in developing industry interest in licensing the technology. And (3) Responsiveness to NASA Requirements: RTI listened to our customer (NASA) and designed our processes to conform with the internal procedures and resources at each NASA Field Center and the direction provided by NASA's Agenda for Change. This report covers the activities of the Research Triangle Institute Technology Applications Team for the period 1 October 1993 through 31 December 1994.

  8. Can CO-tolerant Anodes be Economically Viable for PEMFC Applications with Reformates?

    DOE PAGES

    He, P.; Zhang, Y.; Ye., S.; ...

    2014-10-05

    Several years ago, the answer to this question was negative based on the criteria for an anode with <0.1 mg cm-2 of platinum group metals to perform similarly without and with 50 ppm CO in hydrogen proton exchange membrane fuel cells (PEMFCs). Now, with the amount of CO impurities reduced to 10 ppm in reformates, a <1% performance loss with a 1.5% air-bleed has become a reasonable target. The CO-tolerant catalyst also needs to be dissolution resistant up to 0.93 V, viz., the potential experienced at the anode during startup and shutdown of the fuel cells. We recently demonstrated ourmore » ability to simultaneously enhance activity and stability by using single crystalline Ru@Pt core-shell nanocatalysts. Here, we report that the performance target with reformates was met using bilayer-thick Ru@Pt core-shell nanocatalysts with 0.047 mg cm-2 Pt and 0.024 mg cm-2 Ru loading, supporting a positive prognosis for the economically viable use of reformates in PEMFC applications.« less

  9. Prototype to product—developing a commercially viable neural prosthesis

    NASA Astrophysics Data System (ADS)

    Seligman, Peter

    2009-12-01

    The Cochlear implant or 'Bionic ear' is a device that enables people who do not get sufficient benefit from a hearing aid to communicate with the hearing world. The Cochlear implant is not an amplifier, but a device that electrically stimulates the auditory nerve in a way that crudely mimics normal hearing, thus providing a hearing percept. Many recipients are able to understand running speech without the help of lipreading. Cochlear implants have reached a stage of maturity where there are now 170 000 recipients implanted worldwide. The commercial development of these devices has occurred over the last 30 years. This development has been multidisciplinary, including audiologists, engineers, both mechanical and electrical, histologists, materials scientists, physiologists, surgeons and speech pathologists. This paper will trace the development of the device we have today, from the engineering perspective. The special challenges of designing an active device that will work in the human body for a lifetime will be outlined. These challenges include biocompatibility, extreme reliability, safety, patient fitting and surgical issues. It is emphasized that the successful development of a neural prosthesis requires the partnership of academia and industry.

  10. Prototype to product-developing a commercially viable neural prosthesis.

    PubMed

    Seligman, Peter

    2009-12-01

    The Cochlear implant or 'Bionic ear' is a device that enables people who do not get sufficient benefit from a hearing aid to communicate with the hearing world. The Cochlear implant is not an amplifier, but a device that electrically stimulates the auditory nerve in a way that crudely mimics normal hearing, thus providing a hearing percept. Many recipients are able to understand running speech without the help of lipreading. Cochlear implants have reached a stage of maturity where there are now 170 000 recipients implanted worldwide. The commercial development of these devices has occurred over the last 30 years. This development has been multidisciplinary, including audiologists, engineers, both mechanical and electrical, histologists, materials scientists, physiologists, surgeons and speech pathologists. This paper will trace the development of the device we have today, from the engineering perspective. The special challenges of designing an active device that will work in the human body for a lifetime will be outlined. These challenges include biocompatibility, extreme reliability, safety, patient fitting and surgical issues. It is emphasized that the successful development of a neural prosthesis requires the partnership of academia and industry.

  11. Commercial applications of the ACTS mobile terminal millimeter-wave antennas

    NASA Technical Reports Server (NTRS)

    Densmore, Arthur C.; Crist, Rick A.; Jamnejad, Vahraz; Tulintseff, Ann N.

    1991-01-01

    NASA's Jet Propulsion Laboratory is currently developing the Advanced Communications Technology Satellite (ACTS) Mobile Terminal (AMT), which will provide voice, data, and video communications to and from a vehicle (van, truck, or car) via NASA's geostationary ACTS satellite using the K- and K(sub a)-band frequency bands. The AMT is already planned to demonstrate a variety of communications from within the mobile vehicular environment, and within this paper a summary of foreseen commercial application opportunities is given. A critical component of the AMT is its antenna system, which must establish and maintain the basic RF link with the satellite. Two versions of the antenna are under development, each incorporating different technologies and offering different commercial applications.

  12. The Conceptual Mechanism for Viable Organizational Learning Based on Complex System Theory and the Viable System Model

    ERIC Educational Resources Information Center

    Sung, Dia; You, Yeongmahn; Song, Ji Hoon

    2008-01-01

    The purpose of this research is to explore the possibility of viable learning organizations based on identifying viable organizational learning mechanisms. Two theoretical foundations, complex system theory and viable system theory, have been integrated to provide the rationale for building the sustainable organizational learning mechanism. The…

  13. Fuel cells are a commercially viable alternative for the production of "clean" energy.

    PubMed

    Niakolas, Dimitris K; Daletou, Maria; Neophytides, Stylianos G; Vayenas, Constantinos G

    2016-01-01

    Fuel cells present a highly efficient and environmentally friendly alternative technology for decentralized energy production. The scope of the present study is to provide an overview of the technological and commercialization readiness level of fuel cells. Specifically, there is a brief description of their general advantages and weaknesses in correlation with various technological actions and political strategies, which are adopted towards their proper positioning in the global market. Some of the most important key performance indicators are also discussed, alongside with a few examples of broad commercialization. It is concluded that the increasing number of companies which utilize and invest on this technology, in combination with the supply chain improvements and the concomitant technological maturity and recognition, reinforce the fuel cell industry so as to become well-aligned for global success.

  14. Ornamental and Shade Tree Pest Control: A Guide for Commercial Applicators.

    ERIC Educational Resources Information Center

    Khan, M. S.

    This is a training manual for commercial pesticide applicators. It gives information for identification and control of diseases, insects, mites, weeds, and vertebrate pests of shade and ornamental trees. Phytotoxicity, environmental concerns, and pesticide application information is also given. (BB)

  15. Tests of commercial colour CMOS cameras for astronomical applications

    NASA Astrophysics Data System (ADS)

    Pokhvala, S. M.; Reshetnyk, V. M.; Zhilyaev, B. E.

    2013-12-01

    We present some results of testing commercial colour CMOS cameras for astronomical applications. Colour CMOS sensors allow to perform photometry in three filters simultaneously that gives a great advantage compared with monochrome CCD detectors. The Bayer BGR colour system realized in colour CMOS sensors is close to the astronomical Johnson BVR system. The basic camera characteristics: read noise (e^{-}/pix), thermal noise (e^{-}/pix/sec) and electronic gain (e^{-}/ADU) for the commercial digital camera Canon 5D MarkIII are presented. We give the same characteristics for the scientific high performance cooled CCD camera system ALTA E47. Comparing results for tests of Canon 5D MarkIII and CCD ALTA E47 show that present-day commercial colour CMOS cameras can seriously compete with the scientific CCD cameras in deep astronomical imaging.

  16. 48 CFR 12.503 - Applicability of certain laws to Executive agency contracts for the acquisition of commercial items.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... laws to Executive agency contracts for the acquisition of commercial items. 12.503 Section 12.503... COMMERCIAL ITEMS Applicability of Certain Laws to the Acquisition of Commercial Items and Commercially... acquisition of commercial items. (a) The following laws are not applicable to Executive agency contracts for...

  17. SONOS technology for commercial and military nonvolatile memory applications

    NASA Astrophysics Data System (ADS)

    Adams, D.; Farrell, P.; Jacunski, M.; Williams, D.; Jakubczak, J.; Knoll, M.; Murray, J.

    Silicon Oxide Nitride Oxide Semiconductor (SONOS) technology is well suited for military and commercial nonvolatile memory applications. Excellent long term memory retention, radiation hardness, and endurance has been demonstrated with this technology. This paper summarizes our data in these areas for SONOS technology.

  18. Nonacid meat decontamination technologies: model studies and commercial applications.

    PubMed

    Sofos, J N; Smith, G C

    1998-11-10

    Increased consumer awareness and concern about microbial foodborne diseases has resulted in intensified efforts to reduce contamination of raw meat, as evidenced by new meat and poultry inspection regulations being implemented in the United States. In addition to requiring operation of meat and poultry slaughtering and processing plants under the principles of the hazard analysis critical control point (HACCP) system, the new regulations have established microbiological testing criteria for Escherichia coli and Salmonella, as a means of evaluating plant performance. These developments have renewed and intensified interest in the development and commercial application of meat and poultry decontamination procedures. Technologies developed and evaluated for decontamination include live animal cleaning/washing, chemical dehairing, carcass knife-trimming to remove physical contaminants, steam/hot water-vacuuming for spot-cleaning/decontamination of carcasses, spray washing/rinsing of carcasses with water of low or high pressures and temperatures or chemical solutions, and exposure of carcass sides to pressurized steam. Under appropriate conditions, the technologies applied to carcasses may reduce mean microbiological counts by approximately one-three log colony forming units (cfu)/cm2, and some of them have been approved and are employed in commercial applications (i.e., steam-vacuuming; carcass spray-washing with water, chlorine, organic acid or trisodium phosphate solutions; hot water deluging/spraying/rinsing, and pressurized steam). The contribution of these decontamination technologies to the enhancement of food safety will be determined over the long term, as surveillance data on microbial foodborne illness are collected. This review examines carcass decontamination technologies, other than organic acids, with emphasis placed on recent advances and commercial applications.

  19. The venture space alliance commercial application of microgravity research

    NASA Astrophysics Data System (ADS)

    Whitton, Dave

    1999-01-01

    The Venture Space Alliance is a Canadian commercial enterprise formed to develop a successful sustainable business, providing industrial and institutional clients with cost effective timely access to space and microgravity facilities for commercial and scientific benefit. The goal is to offer users a comprehensive and reliable set of products and services from the early stages of research, where access to short duration microgravity such as drop towers, aircraft and sub-orbital rockets is required, to more complex missions requiring free flyers, shuttle or Space Station. The service is designed to relieve the researcher from having to be concerned with the special processes associated with space flight, and to assist in the commercial application of their research through the development of business plans and investment strategy. Much of this research could lead to new and better medicines, high disease tolerant and more prolific agricultural products, new materials and alloys, and improvements in fundamental human health. This paper will describe the commercial successes derived from microgravity research, and the anticipated growth of this segment particularly with the completion of the International Space Station.

  20. Physical Properties and Durability of New Materials for Space and Commercial Applications

    NASA Technical Reports Server (NTRS)

    Hambourger, Paul D.

    2003-01-01

    To develop and test new materials for use in space power systems and related space and commercial applications, to assist industry in the application of these materials, and to achieve an adequate understanding of the mechanisms by which the materials perform in their intended applications.

  1. Two new advanced forms of spectrometry for space and commercial applications

    NASA Technical Reports Server (NTRS)

    Schlager, Kenneth J.

    1991-01-01

    Reagentless ultraviolet absorption spectrometry (UVAS) and Liquid Atomic Emission Spectrometry (LAES) represent new forms of spectrometry with extensive potential in both space and commercial applications. Originally developed under KSC sponsorship for monitoring nutrient solutions for the Controlled Ecological Life Support System (CELSS), both UVAS and LAES have extensive analytical capabilities for both organic and inorganic chemical compounds. Both forms of instrumentation involve the use of remote fiber optic probes and real-time measurements for on-line process monitoring. Commercial applications exist primarily in environmental analysis and for process control in the chemical, pulp and paper, food processing, metal plating, and water/wastewater treatment industries.

  2. 77 FR 14535 - Agency Information Collection Activities: Application To Use the Automated Commercial Environment...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-03-12

    ... Activities: Application To Use the Automated Commercial Environment (ACE) AGENCY: U.S. Customs and Border... Commercial Environment (ACE). This request for comment is being made pursuant to the Paperwork Reduction Act... Number: None. Abstract: The Automated Commercial Environment (ACE) is a trade processing system that will...

  3. Commercial Application of In-Space Assembly

    NASA Technical Reports Server (NTRS)

    Lymer, John; Hanson, Mark; Tadros, Al; Boccio, Joel; Hollenstein, Bruno; Emerick, Ken; Doughtery, Sean; Doggett, Bill; Dorsey, John T.; King, Bruce D.; hide

    2016-01-01

    In-Space assembly (ISA) expands the opportunities for cost effective emplacement of systems in space. Currently, spacecraft are launched into space and deploy into their operational configuration through a carefully choreographed sequence of operations. The deployment operation dictates the arrangement of the primary systems on the spacecraft, limiting the ability to take full advantage of launch vehicles volume and mass capability. ISA enables vastly different spacecraft architectures and emplacement scenarios to be achieved, including optimal launch configurations ranging from single launch and assembly to on-orbit aggregation of multiple launches at different orbital locations and times. The spacecraft can be visited at different orbital locations and times to effect expansion and maintenance of an operational capability. To date, the primary application of ISA has been in large programs funded by government organizations, such as the International Space Station. Recently, Space Systems Loral (SSL) led a study funded by the Defense Advanced Research Projects Agency (DARPA), called Dragonfly, to investigate the commercial applicability and economic advantages of ISA. In the study, it was shown that ISA enables SSL to double the capability of a commercial satellite system by taking advantage of alternate packaging approaches for the reflectors. The study included an ultra-light-weight robotic system, derived from Mars manipulator designs, to complete assembly of portions of the antenna system using a tool derived from DARPA orbital express and National Aeronautics and Space Administration (NASA) automated structural assembly experience. The mechanical connector that enables robotic ISA takes advantage of decades of development by NASA from the 1970's to 1980's during the Space Station Freedom program, the precursor to the ISS. The mechanical connector was originally designed for rapid astronaut assembly while also providing a high quality structural connection

  4. Risk assessment strategies as nanomaterials transition into commercial applications

    NASA Astrophysics Data System (ADS)

    Olson, Mira S.; Gurian, Patrick L.

    2012-03-01

    Commercial applications of nanomaterials are rapidly emerging in the marketplace. The environmental and human health risks of many nanomaterials remain unknown, and prioritizing how to efficiently assess their risks is essential. As nanomaterials are incorporated into a broader range of commercial products, their potential for environmental release and human exposure not only increases, but also becomes more difficult to model accurately. Emphasis may first be placed on estimating potential environmental exposure based on pertinent physical properties of the nanomaterials. Given that the greatest potential for global environmental impacts results from nanomaterials that are both persistent and toxic, this paper advocates screening first for persistence since it is easier to assess than toxicity. For materials that show potential for persistence, a higher burden of proof of their non-toxicity is suggested before they enter the commercial marketplace whereas a lower burden of proof may be acceptable for nanomaterials that are less persistent.

  5. Peri-viable birth: legal considerations.

    PubMed

    Sayeed, Sadath A

    2014-02-01

    Peri-viable birth raises an array of complex moral and legal concerns. This article discusses the problem with defining viability, touches on its relationship to abortion jurisprudence, and analyzes a few interesting normative implications of current medical practice at the time of peri-viable birth. Copyright © 2014 Elsevier Inc. All rights reserved.

  6. 47 CFR 1.526 - Records to be maintained locally for public inspection by commercial applicants, permittees and...

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... inspection by commercial applicants, permittees and licensees. 1.526 Section 1.526 Telecommunication FEDERAL COMMUNICATIONS COMMISSION GENERAL PRACTICE AND PROCEDURE Broadcast Applications and Proceedings General Filing Requirements § 1.526 Records to be maintained locally for public inspection by commercial applicants...

  7. Guidelines for use of Hydrogen Fuel in Commercial Vehicles

    DOT National Transportation Integrated Search

    2008-01-01

    Over the next 50 years, hydrogen use is expected to grow dramatically as an automotive and electrical power source fuel. As hydrogen becomes commercially viable, the safety concerns associated with hydrogen systems, equipment, and operation are of co...

  8. Non-commercial vs. commercial clinical trials: a retrospective study of the applications submitted to a research ethics committee.

    PubMed

    Fuentes Camps, Inmaculada; Rodríguez, Alexis; Agustí, Antonia

    2018-06-01

    There are many difficulties in undertaking independent clinical research without support from the pharmaceutical industry. In this retrospective observational study, some design characteristics, the clinical trial public register and the publication rate of noncommercial clinical trials were compared to those of commercial clinical trials. A total of 809 applications of drug-evaluation clinical trials were submitted from May 2004 to May 2009 to the research ethics committee of a tertiary hospital, and 16.3% of trials were noncommercial. They were mainly phase IV, multicentre national, and unmasked controlled trials, compared to the commercial trials that were mainly phase II or III, multicentre international, and double-blind masked trials. The commercial trials were registered and published more often than noncommercial trials. More funding for noncommercial research is still needed. The results of the research, commercial or noncommercial, should be disseminated in order not to compromise either its scientific or its social value. © 2018 The British Pharmacological Society.

  9. Production, formulation and cost estimation of a commercial biosurfactant.

    PubMed

    Soares da Silva, Rita de Cássia Freire; de Almeida, Darne Germano; Brasileiro, Pedro Pinto Ferreira; Rufino, Raquel Diniz; de Luna, Juliana Moura; Sarubbo, Leonie Asfora

    2018-05-03

    Due to their amphipathic nature, biosurfactants are multifunctional molecules that have considerable potential in several industries, especially the petroleum industry. In this study, the commercial production of a biosurfactant from Pseudomonas cepacia CCT6659 grown on industrial waste was investigated in a semi-industrial 50-L bioreactor for use in the removal of hydrocarbons from oily effluents. A concentration of 40.5 g/L was achieved in the scale up and the surface tension was reduced to 29 mN/m. The biosurfactant was formulated with an added preservative, tyndallization and the combination of fluent vaporization plus the preservative. Formulated biosurfactant samples were stored for 120 days. Tensioactive properties and stability were evaluated with different pH values, temperatures and salt concentrations. The commercial biosurfactant obtained with all formulation methods demonstrated good stability, with tolerance to a wide range of pH values as well as high temperature and high salinity, enabling application in extreme environmental conditions, as it occurs in industrial plants. The biosurfactant proved to be economically viable for large-scale application, as demonstrated by the cost of the product, estimated at around US$ 0.14-0.15/L and US$ 0.02/g for the formulated and the isolated biosurfactant, respectively. Both products were applied in an oil-fired thermoelectric plant for the treatment of oily effluents and removed up to 100% of the oil. Therefore, this biosurfactant is suitable for application under extreme conditions, such as in the petroleum industry, and can be produced at a more attractive price compared to other commercially available products on the market.

  10. Space Commercial Opportunities for Fluid Physics and Transport Phenomena Applications

    NASA Technical Reports Server (NTRS)

    Gavert, R.

    2000-01-01

    Microgravity research at NASA has been an undertaking that has included both science and commercial approaches since the late 80s and early 90s. The Fluid Physics and Transport Phenomena community has been developed, through NASA's science grants, into a valuable base of expertise in microgravity science. This was achieved through both ground and flight scientific research. Commercial microgravity research has been primarily promoted thorough NASA sponsored Centers for Space Commercialization which develop cost sharing partnerships with industry. As an example, the Center for Advanced Microgravity Materials Processing (CAMMP)at Northeastern University has been working with cost sharing industry partners in developing Zeolites and zeo-type materials as an efficient storage medium for hydrogen fuel. Greater commercial interest is emerging. The U.S. Congress has passed the Commercial Space Act of 1998 to encourage the development of a commercial space industry in the United States. The Act has provisions for the commercialization of the International Space Station (ISS). Increased efforts have been made by NASA to enable industrial ventures on-board the ISS. A Web site has been established at http://commercial/nasa/gov which includes two important special announcements. One is an open request for entrepreneurial offers related to the commercial development and use of the ISS. The second is a price structure and schedule for U.S. resources and accommodations. The purpose of the presentation is to make the Fluid Physics and Transport Phenomena community, which understands the importance of microgravity experimentation, aware of important aspects of ISS commercial development. It is a desire that this awareness will be translated into a recognition of Fluid Physics and Transport Phenomena application opportunities coordinated through the broad contacts of this community with industry.

  11. 43 CFR 9266.4 - Viable coral communities.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 43 Public Lands: Interior 2 2014-10-01 2014-10-01 false Viable coral communities. 9266.4 Section... § 9266.4 Viable coral communities. (a) Requirement for a permit. No person shall engage in any operation which directly causes damage or injury to a viable coral community that is located on the Outer...

  12. 43 CFR 9266.4 - Viable coral communities.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 43 Public Lands: Interior 2 2011-10-01 2011-10-01 false Viable coral communities. 9266.4 Section... § 9266.4 Viable coral communities. (a) Requirement for a permit. No person shall engage in any operation which directly causes damage or injury to a viable coral community that is located on the Outer...

  13. 43 CFR 9266.4 - Viable coral communities.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 43 Public Lands: Interior 2 2012-10-01 2012-10-01 false Viable coral communities. 9266.4 Section... § 9266.4 Viable coral communities. (a) Requirement for a permit. No person shall engage in any operation which directly causes damage or injury to a viable coral community that is located on the Outer...

  14. 43 CFR 9266.4 - Viable coral communities.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 43 Public Lands: Interior 2 2013-10-01 2013-10-01 false Viable coral communities. 9266.4 Section... § 9266.4 Viable coral communities. (a) Requirement for a permit. No person shall engage in any operation which directly causes damage or injury to a viable coral community that is located on the Outer...

  15. Rapid enumeration of viable bacteria by image analysis

    NASA Technical Reports Server (NTRS)

    Singh, A.; Pyle, B. H.; McFeters, G. A.

    1989-01-01

    A direct viable counting method for enumerating viable bacteria was modified and made compatible with image analysis. A comparison was made between viable cell counts determined by the spread plate method and direct viable counts obtained using epifluorescence microscopy either manually or by automatic image analysis. Cultures of Escherichia coli, Salmonella typhimurium, Vibrio cholerae, Yersinia enterocolitica and Pseudomonas aeruginosa were incubated at 35 degrees C in a dilute nutrient medium containing nalidixic acid. Filtered samples were stained for epifluorescence microscopy and analysed manually as well as by image analysis. Cells enlarged after incubation were considered viable. The viable cell counts determined using image analysis were higher than those obtained by either the direct manual count of viable cells or spread plate methods. The volume of sample filtered or the number of cells in the original sample did not influence the efficiency of the method. However, the optimal concentration of nalidixic acid (2.5-20 micrograms ml-1) and length of incubation (4-8 h) varied with the culture tested. The results of this study showed that under optimal conditions, the modification of the direct viable count method in combination with image analysis microscopy provided an efficient and quantitative technique for counting viable bacteria in a short time.

  16. Application of adaptive antenna techniques to future commercial satellite communications. Executive summary

    NASA Technical Reports Server (NTRS)

    Ersoy, L.; Lee, E. A.; Matthews, E. W.

    1987-01-01

    The purpose of this contract was to identify the application of adaptive antenna technique in future operational commercial satellite communication systems and to quantify potential benefits. The contract consisted of two major subtasks. Task 1, Assessment of Future Commercial Satellite System Requirements, was generally referred to as the Adaptive section. Task 2 dealt with Pointing Error Compensation Study for a Multiple Scanning/Fixed Spot Beam Reflector Antenna System and was referred to as the reconfigurable system. Each of these tasks was further subdivided into smaller subtasks. It should also be noted that the reconfigurable system is usually defined as an open-loop system while the adaptive system is a closed-loop system. The differences between the open- and closed-loop systems were defined. Both the adaptive and reconfigurable systems were explained and the potential applications of such systems were presented in the context of commercial communication satellite systems.

  17. Limitations of Commercializing Fuel Cell Technologies

    NASA Astrophysics Data System (ADS)

    Nordin, Normayati

    2010-06-01

    Fuel cell is the technology that, nowadays, is deemed having a great potential to be used in supplying energy. Basically, fuel cells can be categorized particularly by the kind of employed electrolyte. Several fuel cells types which are currently identified having huge potential to be utilized, namely, Solid Oxide Fuel Cells (SOFC), Molten Carbonate Fuel Cells (MCFC), Alkaline Fuel Cells (AFC), Phosphoric Acid Fuel Cells (PAFC), Polymer Electron Membrane Fuel Cell (PEMFC), Direct Methanol Fuel Cells (DMFC) and Regenerative Fuel Cells (RFC). In general, each of these fuel cells types has their own characteristics and specifications which assign the capability and suitability of them to be utilized for any particular applications. Stationary power generations and transport applications are the two most significant applications currently aimed for the fuel cell market. It is generally accepted that there are lots of advantages if fuel cells can be excessively commercialized primarily in context of environmental concerns and energy security. Nevertheless, this is a demanding task to be accomplished, as there is some gap in fuel cells technology itself which needs a major enhancement. It can be concluded, from the previous study, cost, durability and performance are identified as the main limitations to be firstly overcome in enabling fuel cells technology become viable for the market.

  18. Viable Mycobacterium avium ssp. paratuberculosis isolated from calf milk replacer.

    PubMed

    Grant, Irene R; Foddai, Antonio C G; Tarrant, James C; Kunkel, Brenna; Hartmann, Faye A; McGuirk, Sheila; Hansen, Chungyi; Talaat, Adel M; Collins, Michael T

    2017-12-01

    When advising farmers on how to control Johne's disease in an infected herd, one of the main recommendations is to avoid feeding waste milk to calves and instead feed calf milk replacer (CMR). This advice is based on the assumption that CMR is free of viable Mycobacterium avium ssp. paratuberculosis (MAP) cells, an assumption that has not previously been challenged. We tested commercial CMR products (n = 83) obtained from dairy farms around the United States by the peptide-mediated magnetic separation (PMS)-phage assay, PMS followed by liquid culture (PMS-culture), and direct IS900 quantitative PCR (qPCR). Conventional microbiological analyses for total mesophilic bacterial counts, coliforms, Salmonella, coagulase-negative staphylococci, streptococci, nonhemolytic Corynebacterium spp., and Bacillus spp. were also performed to assess the overall microbiological quality of the CMR. Twenty-six (31.3%) of the 83 CMR samples showed evidence of the presence of MAP. Seventeen (20.5%) tested positive for viable MAP by the PMS-phage assay, with plaque counts ranging from 6 to 1,212 pfu/50 mL of reconstituted CMR (average 248.5 pfu/50 mL). Twelve (14.5%) CMR samples tested positive for viable MAP by PMS-culture; isolates from all 12 of these samples were subsequently confirmed by whole-genome sequencing to be different cattle strains of MAP. Seven (8.4%) CMR samples tested positive for MAP DNA by IS900 qPCR. Four CMR samples tested positive by both PMS-based tests and 5 CMR samples tested positive by IS900 qPCR plus one or other of the PMS-based tests, but only one CMR sample tested positive by all 3 MAP detection tests applied. All conventional microbiology results were within current standards for whole milk powders. A significant association existed between higher total bacterial counts and presence of viable MAP indicated by either of the PMS-based assays. This represents the first published report of the isolation of viable MAP from CMR. Our findings raise concerns

  19. 36 CFR 13.1142 - Can I appeal denial of my commercial fishing lifetime access permit application?

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... commercial fishing lifetime access permit application? 13.1142 Section 13.1142 Parks, Forests, and Public... Regulations-Glacier Bay National Park and Preserve Commercial Fishing § 13.1142 Can I appeal denial of my... lifetime access permit is denied, the superintendent will provide the applicant with the reasons for the...

  20. PMA-PhyloChip DNA Microarray to Elucidate Viable Microbial Community Structure

    NASA Technical Reports Server (NTRS)

    Venkateswaran, Kasthuri J.; Stam, Christina N.; Andersen, Gary L.; DeSantis, Todd

    2011-01-01

    Since the Viking missions in the mid-1970s, traditional culture-based methods have been used for microbial enumeration by various NASA programs. Viable microbes are of particular concern for spacecraft cleanliness, for forward contamination of extraterrestrial bodies (proliferation of microbes), and for crew health/safety (viable pathogenic microbes). However, a "true" estimation of viable microbial population and differentiation from their dead cells using the most sensitive molecular methods is a challenge, because of the stability of DNA from dead cells. The goal of this research is to evaluate a rapid and sensitive microbial detection concept that will selectively estimate viable microbes. Nucleic acid amplification approaches such as the polymerase chain reaction (PCR) have shown promise for reducing time to detection for a wide range of applications. The proposed method is based on the use of a fluorescent DNA intercalating agent, propidium monoazide (PMA), which can only penetrate the membrane of dead cells. The PMA-quenched reaction mixtures can be screened, where only the DNA from live cells will be available for subsequent PCR reaction and microarray detection, and be identified as part of the viable microbial community. An additional advantage of the proposed rapid method is that it will detect viable microbes and differentiate from dead cells in only a few hours, as opposed to less comprehensive culture-based assays, which take days to complete. This novel combination approach is called the PMA-Microarray method. DNA intercalating agents such as PMA have previously been used to selectively distinguish between viable and dead bacterial cells. Once in the cell, the dye intercalates with the DNA and, upon photolysis under visible light, produces stable DNA adducts. DNA cross-linked in this way is unavailable for PCR. Environmental samples suspected of containing a mixture of live and dead microbial cells/spores will be treated with PMA, and then incubated

  1. 36 CFR 28.13 - Variance, commercial and industrial application procedures.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 36 Parks, Forests, and Public Property 1 2010-07-01 2010-07-01 false Variance, commercial and industrial application procedures. 28.13 Section 28.13 Parks, Forests, and Public Property NATIONAL PARK SERVICE, DEPARTMENT OF THE INTERIOR FIRE ISLAND NATIONAL SEASHORE: ZONING STANDARDS Federal Standards and...

  2. 36 CFR 28.13 - Variance, commercial and industrial application procedures.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 36 Parks, Forests, and Public Property 1 2011-07-01 2011-07-01 false Variance, commercial and industrial application procedures. 28.13 Section 28.13 Parks, Forests, and Public Property NATIONAL PARK SERVICE, DEPARTMENT OF THE INTERIOR FIRE ISLAND NATIONAL SEASHORE: ZONING STANDARDS Federal Standards and...

  3. Developing Viable Financing Models for Space Tourism

    NASA Astrophysics Data System (ADS)

    Eilingsfeld, F.; Schaetzler, D.

    2002-01-01

    Increasing commercialization of space services and the impending release of government's control of space access promise to make space ventures more attractive. Still, many investors shy away from going into the space tourism market as long as they do not feel secure that their return expectations will be met. First and foremost, attracting investors from the capital markets requires qualifying financing models. Based on earlier research on the cost of capital for space tourism, this paper gives a brief run-through of commercial, technical and financial due diligence aspects. After that, a closer look is taken at different valuation techniques as well as alternative ways of streamlining financials. Experience from earlier ventures has shown that the high cost of capital represents a significant challenge. Thus, the sophistication and professionalism of business plans and financial models needs to be very high. Special emphasis is given to the optimization of the debt-to-equity ratio over time. The different roles of equity and debt over a venture's life cycle are explained. Based on the latter, guidelines for the design of an optimized loan structure are given. These are then applied to simulating the financial performance of a typical space tourism venture over time, including the calculation of Weighted Average Cost of Capital (WACC) and Net Present Value (NPV). Based on a concluding sensitivity analysis, the lessons learned are presented. If applied properly, these will help to make space tourism economically viable.

  4. The science, development, and commercialization of postharvest biocontrol products

    USDA-ARS?s Scientific Manuscript database

    Postharvest biological control agents as a viable alternative to the use of synthetic chemicals have been the focus of considerable research for the last 30 years by many scientists and several commercial companies worldwide. Several antagonists of postharvest pathogens have been identified and tes...

  5. Mobile clinical decision support systems and applications: a literature and commercial review.

    PubMed

    Martínez-Pérez, Borja; de la Torre-Díez, Isabel; López-Coronado, Miguel; Sainz-de-Abajo, Beatriz; Robles, Montserrat; García-Gómez, Juan Miguel

    2014-01-01

    The latest advances in eHealth and mHealth have propitiated the rapidly creation and expansion of mobile applications for health care. One of these types of applications are the clinical decision support systems, which nowadays are being implemented in mobile apps to facilitate the access to health care professionals in their daily clinical decisions. The aim of this paper is twofold. Firstly, to make a review of the current systems available in the literature and in commercial stores. Secondly, to analyze a sample of applications in order to obtain some conclusions and recommendations. Two reviews have been done: a literature review on Scopus, IEEE Xplore, Web of Knowledge and PubMed and a commercial review on Google play and the App Store. Five applications from each review have been selected to develop an in-depth analysis and to obtain more information about the mobile clinical decision support systems. Ninety-two relevant papers and 192 commercial apps were found. Forty-four papers were focused only on mobile clinical decision support systems. One hundred seventy-one apps were available on Google play and 21 on the App Store. The apps are designed for general medicine and 37 different specialties, with some features common in all of them despite of the different medical fields objective. The number of mobile clinical decision support applications and their inclusion in clinical practices has risen in the last years. However, developers must be careful with their interface or the easiness of use, which can impoverish the experience of the users.

  6. Hoechst fluorescence intensity can be used to separate viable bromodeoxyuridine-labeled cells from viable non-bromodeoxyuridine-labeled cells

    NASA Technical Reports Server (NTRS)

    Mozdziak, P. E.; Pulvermacher, P. M.; Schultz, E.; Schell, K.

    2000-01-01

    BACKGROUND: 5-Bromo-2'-deoxyuridine (BrdU) is a powerful compound to study the mitotic activity of a cell. Most techniques that identify BrdU-labeled cells require conditions that kill the cells. However, the fluorescence intensity of the membrane-permeable Hoechst dyes is reduced by the incorporation of BrdU into DNA, allowing the separation of viable BrdU positive (BrdU+) cells from viable BrdU negative (BrdU-) cells. METHODS: Cultures of proliferating cells were supplemented with BrdU for 48 h and other cultures of proliferating cells were maintained without BrdU. Mixtures of viable BrdU+ and viable BrdU- cells from the two proliferating cultures were stained with Hoechst 33342. The viable BrdU+ and BrdU- cells were sorted into different fractions from a mixture of BrdU+ and BrdU- cells based on Hoechst fluorescence intensity and the ability to exclude the vital dye, propidium iodide. Subsequently, samples from the original mixture, the sorted BrdU+ cell population, and the sorted BrdU- cell population were immunostained using an anti-BrdU monoclonal antibody and evaluated using flow cytometry. RESULTS: Two mixtures consisting of approximately 55% and 69% BrdU+ cells were sorted into fractions consisting of greater than 93% BrdU+ cells and 92% BrdU- cells. The separated cell populations were maintained in vitro after sorting to demonstrate their viability. CONCLUSIONS: Hoechst fluorescence intensity in combination with cell sorting is an effective tool to separate viable BrdU+ from viable BrdU- cells for further study. The separated cell populations were maintained in vitro after sorting to demonstrate their viability. Copyright 2000 Wiley-Liss, Inc.

  7. Development of a commercially viable piezoelectric force sensor system for static force measurement

    NASA Astrophysics Data System (ADS)

    Liu, Jun; Luo, Xinwei; Liu, Jingcheng; Li, Min; Qin, Lan

    2017-09-01

    A compensation method for measuring static force with a commercial piezoelectric force sensor is proposed to disprove the theory that piezoelectric sensors and generators can only operate under dynamic force. After studying the model of the piezoelectric force sensor measurement system, the principle of static force measurement using a piezoelectric material or piezoelectric force sensor is analyzed. Then, the distribution law of the decay time constant of the measurement system and the variation law of the measurement system’s output are studied, and a compensation method based on the time interval threshold Δ t and attenuation threshold Δ {{u}th} is proposed. By calibrating the system and considering the influences of the environment and the hardware, a suitable Δ {{u}th} value is determined, and the system’s output attenuation is compensated based on the Δ {{u}th} value to realize the measurement. Finally, a static force measurement system with a piezoelectric force sensor is developed based on the compensation method. The experimental results confirm the successful development of a simple compensation method for static force measurement with a commercial piezoelectric force sensor. In addition, it is established that, contrary to the current perception, a piezoelectric force sensor system can be used to measure static force through further calibration.

  8. The use of flow cytometry to accurately ascertain total and viable counts of Lactobacillus rhamnosus in chocolate.

    PubMed

    Raymond, Yves; Champagne, Claude P

    2015-04-01

    The goals of this study were to evaluate the precision and accuracy of flow cytometry (FC) methodologies in the evaluation of populations of probiotic bacteria (Lactobacillus rhamnosus R0011) in two commercial dried forms, and ascertain the challenges in enumerating them in a chocolate matrix. FC analyses of total (FC(T)) and viable (FC(V)) counts in liquid or dried cultures were almost two times more precise (reproducible) than traditional direct microscopic counts (DCM) or colony forming units (CFU). With FC, it was possible to ascertain low levels of dead cells (FC(D)) in fresh cultures, which is not possible with traditional CFU and DMC methodologies. There was no interference of chocolate solids on FC counts of probiotics when inoculation was above 10(7) bacteria per g. Addition of probiotics in chocolate at 40 °C resulted in a 37% loss in viable cells. Blending of the probiotic powder into chocolate was not uniform which raised a concern that the precision of viable counts could suffer. FCT data can serve to identify the correct inoculation level of a sample, and viable counts (FCV or CFU) can subsequently be better interpreted. Crown Copyright © 2014. Published by Elsevier Ltd. All rights reserved.

  9. Thermoresponsive release of viable microfiltrated Circulating Tumor Cells (CTCs) for precision medicine applications

    PubMed Central

    Ao, Zheng; Parasido, Erika; Rawal, Siddarth; Williams, Anthony; Schlegel, Richard; Liu, Stephen; Albanese, Chris; Cote, Richard J.; Agarwal, Ashutosh; Datar, Ram H.

    2015-01-01

    Stimulus responsive release of Circulating Tumor Cells (CTCs), with high recovery rates from their capture platform, is highly desirable for off-chip analyses. Here, we present a temperature responsive polymer coating method to achieve both release as well as culture of viable CTCs captured from patient blood samples. PMID:26426331

  10. High-energy radiation and polymers: A review of commercial processes and emerging applications

    NASA Astrophysics Data System (ADS)

    Clough, R. L.

    2001-12-01

    Ionizing radiation has been found to be widely applicable in modifying the structure and properties of polymers, and can be used to tailor the performance of either bulk materials or surfaces. Fifty years of research in polymer radiation chemistry has led to numerous applications of commercial and economic importance, and work remains active in the application of radiation to practical uses involving polymeric materials. This paper provides a survey of radiation-processing methods of industrial interest, ranging from technologies already commercially well established, through innovations in the active R&D stage which show exceptional promise for future commercial use. Radiation-processing technologies are discussed under the following categories: cross-linking of plastics and rubbers, curing of coatings and inks, heat-shrink products, fiber-matrix composites, chain-scission for processing control, surface modification, grafting, hydrogels, sterilization, natural product enhancement, plastics recycling, ceramic precursors, electronic property materials, ion-track membranes and lithography for microdevice production. In addition to new technological innovations utilizing conventional gamma and e-beam sources, a number of promising new applications make use of novel radiation types which include ion beams (heavy ions, light ions, highly focused microscopic beams and high-intensity pulses), soft X-rays which are focused, coherent X-rays (from a synchrotron) and e-beams which undergo scattering to generate patterns.

  11. Commercial Pesticides Applicator Manual: Industrial, Institutional, Structural and Health Related.

    ERIC Educational Resources Information Center

    Fitzwater, William D.; Renes, Robert

    This training manual provides information needed to meet the minimum EPA standards for certification as a commercial applicator of pesticides in the industrial, institutional, structural and health related pest control category. The text discusses the use and safety of applying pesticides to control invertebrate and vertebrate pests such as ants,…

  12. 75 FR 12561 - Request for Applicants for Appointment to the Advisory Committee on Commercial Operations of...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-03-16

    ... Appointment to the Advisory Committee on Commercial Operations of Customs and Border Protection (COAC) AGENCY... Management; request for applicants for appointment to the Advisory Committee on Commercial Operations of... individuals who are interested in serving on the Advisory Committee on Commercial Operations of Customs and...

  13. NASA's commercial space program - Initiatives for the future

    NASA Technical Reports Server (NTRS)

    Rose, James T.; Stone, Barbara A.

    1990-01-01

    NASA's commercial development of the space program aimed at the stimulation and assistance of expanded private sector involvement and investment in civil space activities is discussed, focusing on major new program initiatives and their implementation. NASA's Centers for the Commercial Development of Space (CCDS) program, composed of competitively selected consortia of universities, industries, and government involved in early research and testing phases of potentially commercially viable technologies is described. The 16 centers concentrate on seven different technical areas such as automation and robotics; remote sensing; life sciences; and space power, propulsion, and structures. Private sector participation, CCDS technology development, government and commercially supplied access to space in support of CCDS programs, CCDS hardware development, and CCDS spinoffs are discussed together with various cooperative and reimbursable agreements between NASA and the private sector.

  14. Campylobacter jejuni in commercial eggs.

    PubMed

    Fonseca, Belchiolina Beatriz; Beletti, Marcelo Emílio; de Melo, Roberta Torres; Mendonça, Eliane Pereira; Coelho, Letícia Ríspoli; Nalevaiko, Priscila Christen; Rossi, Daise Aparecida

    2014-01-01

    This study evaluated the ability of Campylobacter jejuni to penetrate through the pores of the shells of commercial eggs and colonize the interior of these eggs, which may become a risk factor for human infection. Furthermore, this study assessed the survival and viability of the bacteria in commercial eggs. The eggs were placed in contact with wood shavings infected with C. jejuni to check the passage of the bacteria. In parallel, the bacteria were inoculated directly into the air chamber to assess the viability in the egg yolk. To determine whether the albumen and egg fertility interferes with the entry and survival of bacteria, we used varying concentrations of albumen and SPF and commercial eggs. C. jejuni was recovered in SPF eggs (fertile) after three hours in contact with contaminated wood shavings but not in infertile commercial eggs. The colonies isolated in the SPF eggs were identified by multiplex PCR and the similarity between strains verified by RAPD-PCR. The bacteria grew in different concentrations of albumen in commercial and SPF eggs. We did not find C. jejuni in commercial eggs inoculated directly into the air chamber, but the bacteria were viable during all periods tested in the wood shavings. This study shows that consumption of commercial eggs infected with C. jejuni does not represent a potential risk to human health.

  15. Programmatic and economic challenges for commercial space processing

    NASA Astrophysics Data System (ADS)

    Overfelt, Tony; Watkins, John

    1997-01-01

    The International Space Station is the largest cooperative space project in history and is likely to be industry's most viable access to the low-g environment for long duration materials processing experiments. Such access will provide unique and competitive research capabilities to industry if private sector entities can commercially utilize the Space Station for their industrial projects. Although ``commercial utilization'' implies a variety of things to different people, the key industrial issues are frequent, reliable, and economical access to space as well as protection of private sector intellectual property rights. This paper discusses how these key issues will influence the programmatic and economic challenges for commercial space processing in the future Space Station era.

  16. Application of narrow-band television to industrial and commercial communications

    NASA Technical Reports Server (NTRS)

    Embrey, B. C., Jr.; Southworth, G. R.

    1974-01-01

    The development of narrow-band systems for use in space systems is presented. Applications of the technology to future spacecraft requirements are discussed along with narrow-band television's influence in stimulating development within the industry. The transferral of the technology into industrial and commercial communications is described. Major areas included are: (1) medicine; (2) education; (3) remote sensing for traffic control; and (5) weather observation. Applications in data processing, image enhancement, and information retrieval are provided by the combination of the TV camera and the computer.

  17. Applications of pectinases in the commercial sector: a review.

    PubMed

    Kashyap, D R; Vohra, P K; Chopra, S; Tewari, R

    2001-05-01

    Pectinases are one of the upcoming enzymes of fruit and textile industries. These enzymes break down complex polysaccharides of plant tissues into simpler molecules like galacturonic acids. The role of acidic pectinases in bringing down the cloudiness and bitterness of fruit juices is well established. Recently, there has been a good number of reports on the application of alkaline pectinases in the textile industry for the retting and degumming of fiber crops, production of good quality paper, fermentation of coffee and tea, oil extractions and treatment of pectic waste water. This review discusses various types of pectinases and their applications in the commercial sector.

  18. Commercial applications of new photovoltaic technologies

    NASA Technical Reports Server (NTRS)

    Mcconnell, R.

    1991-01-01

    The National Renewable Energy Laboratory (NREL) has directed and managed photovoltaic (PV) research and development (R&D) activities for the Department of Energy for more than 13 years. The NREL budget for these activities is almost $33 million for FY 1991. With the world's increasing concern for the environment and the United States' renewed apprehension over secure and adequate energy supplies, the use of semiconducting materials for the direct conversion of sunlight to electricity - photovoltaics - is an excellent example of government-supported high technology ready for further development by U.S. companies. Some new PV technologies and their research progress, some commercial applications of PV, and NREL's technology transfer activities for helping U.S. industry in its efforts to bring new products or services to the marketplace are described.

  19. A study of factors related to commercial space platform services

    NASA Technical Reports Server (NTRS)

    Hosenball, S. N.

    1986-01-01

    In the past four years, the issue of the commercial development of space has come to the forefront of the U. S. national space policy. Though the Administration, Congress and NASA have all shown strong support for encouraging the private sector to become more actively involved in the commercial utilization of space, the question remains whether they must do more to foster the creation and development of a viable U. S. commercial space industry. Marketing aspects, insurance and risk loss, tax related factors, space transportation, termination liability, institutional barriers, and procurement laws and regulations are discussed.

  20. Energy simulation and optimization for a small commercial building through Modelica

    NASA Astrophysics Data System (ADS)

    Rivas, Bryan

    Small commercial buildings make up the majority of buildings in the United States. Energy consumed by these buildings is expected to drastically increase in the next few decades, with a large percentage of the energy consumed attributed to cooling systems. This work presents the simulation and optimization of a thermostat schedule to minimize energy consumption in a small commercial building test bed during the cooling season. The simulation occurs through the use of the multi-engineering domain Dymola environment based on the Modelica open source programming language and is optimized with the Java based optimization program GenOpt. The simulation uses both physically based modeling utilizing heat transfer principles for the building and regression analysis for energy consumption. GenOpt is dynamically coupled to Dymola through various interface files. There are very few studies that have coupled GenOpt to a building simulation program and even fewer studies have used Dymola for building simulation as extensively as the work presented here. The work presented proves Dymola as a viable alternative to other building simulation programs such as EnergyPlus and MatLab. The model developed is used to simulate the energy consumption of a test bed, a commissioned real world small commercial building, while maintaining indoor thermal comfort. Potential applications include smart or intelligent building systems, predictive simulation of small commercial buildings, and building diagnostics.

  1. Intelligent herbicide application system for reduced herbicide vegetation control : phase II-commercialization

    DOT National Transportation Integrated Search

    2008-12-01

    This report describes the development of a commercial prototype intelligent herbicide application system : (IHAS). The improved design incorporates a parallel add-on type fluid handling system to allow existing : variable-rate herbicide injecti...

  2. Axenic isolation of viable Giardia muris trophozoites.

    PubMed

    Tillotson, K D; Buret, A; Olson, M E

    1991-06-01

    Large numbers of viable Giardia muris trophozoites were isolated from the duodenum of experimentally infected mice 6 days after inoculation with 1,000 G. muris cysts. A series of shaking, incubation, and washing steps in the presence of the broad-spectrum antibiotic piperacillin readily provided 4.9 +/- 1.5 x 10(5) G. muris trophozoites per mouse, free of detectable contaminant organisms. Anaerobic and microaerophilic culturing and scanning electron microscopy demonstrated axenic status and high purity of the isolates. The viability of trophozoites was 98 +/- 2%. Application of this technique should permit novel immunological and epidemiological analyses of G. muris infection and biochemical investigations of this protozoan parasite.

  3. Film forming microbial biopolymers for commercial applications--a review.

    PubMed

    Vijayendra, S V N; Shamala, T R

    2014-12-01

    Microorganisms synthesize intracellular, structural and extracellular polymers also referred to as biopolymers for their function and survival. These biopolymers play specific roles as energy reserve materials, protective agents, aid in cell functioning, the establishment of symbiosis, osmotic adaptation and support the microbial genera to function, adapt, multiply and survive efficiently under changing environmental conditions. Viscosifying, gelling and film forming properties of these have been exploited for specific significant applications in food and allied industries. Intensive research activities and recent achievements in relevant and important research fields of global interest regarding film forming microbial biopolymers is the subject of this review. Microbial polymers such as pullulan, kefiran, bacterial cellulose (BC), gellan and levan are placed under the category of exopolysaccharides (EPS) and have several other functional properties including film formation, which can be used for various applications in food and allied industries. In addition to EPS, innumerable bacterial genera are found to synthesis carbon energy reserves in their cells known as polyhydroxyalkanoates (PHAs), microbial polyesters, which can be extruded into films with excellent moisture and oxygen barrier properties. Blow moldable biopolymers like PHA along with polylactic acid (PLA) synthesized chemically in vitro using lactic acid (LA), which is produced by LA bacteria through fermentation, are projected as biodegradable polymers of the future for packaging applications. Designing and creating of new property based on requirements through controlled synthesis can lead to improvement in properties of existing polysaccharides and create novel biopolymers of great commercial interest and value for wider applications. Incorporation of antimicrobials such as bacteriocins or silver and copper nanoparticles can enhance the functionality of polymer films especially in food packaging

  4. Application of the airborne ocean color imager for commercial fishing

    NASA Technical Reports Server (NTRS)

    Wrigley, Robert C.

    1993-01-01

    The objective of the investigation was to develop a commercial remote sensing system for providing near-real-time data (within one day) in support of commercial fishing operations. The Airborne Ocean Color Imager (AOCI) had been built for NASA by Daedalus Enterprises, Inc., but it needed certain improvements, data processing software, and a delivery system to make it into a commercial system for fisheries. Two products were developed to support this effort: the AOCI with its associated processing system and an information service for both commercial and recreational fisheries to be created by Spectro Scan, Inc. The investigation achieved all technical objectives: improving the AOCI, creating software for atmospheric correction and bio-optical output products, georeferencing the output products, and creating a delivery system to get those products into the hands of commercial and recreational fishermen in near-real-time. The first set of business objectives involved Daedalus Enterprises and also were achieved: they have an improved AOCI and new data processing software with a set of example data products for fisheries applications to show their customers. Daedalus' marketing activities showed the need for simplification of the product for fisheries, but they successfully marketed the current version to an Italian consortium. The second set of business objectives tasked Spectro Scan to provide an information service and they could not be achieved because Spectro Scan was unable to obtain necessary venture capital to start up operations.

  5. A Hazardous Gas Detection System for Aerospace and Commercial Applications

    NASA Technical Reports Server (NTRS)

    Hunter, G. W.; Neudeck, P. G.; Chen, L. - Y.; Makel, D. B.; Liu, C. C.; Wu, Q. H.; Knight, D.

    1998-01-01

    The detection of explosive conditions in aerospace propulsion applications is important for safety and economic reasons. Microfabricated hydrogen, oxygen, and hydrocarbon sensors as well as the accompanying hardware and software are being developed for a range of aerospace safety applications. The development of these sensors is being done using MEMS (Micro ElectroMechanical Systems) based technology and SiC-based semiconductor technology. The hardware and software allows control and interrogation of each sensor head and reduces accompanying cabling through multiplexing. These systems are being applied on the X-33 and on an upcoming STS-95 Shuttle mission. A number of commercial applications are also being pursued. It is concluded that this MEMS-based technology has significant potential to reduce costs and increase safety in a variety of aerospace applications.

  6. A Hazardous Gas Detection System for Aerospace and Commercial Applications

    NASA Technical Reports Server (NTRS)

    Hunter, G. W.; Neudeck, P. G.; Chen, L.-Y.; Makel, D. B.; Liu, C. C.; Wu, Q. H.; Knight, D.

    1998-01-01

    The detection of explosive conditions in aerospace propulsion applications is important for safety and economic reasons. Microfabricated hydrogen, oxygen, and hydrocarbon sensors as well as the accompanying hardware and software are being, developed for a range of aerospace safety applications. The development of these sensors is being done using MEMS (Micro ElectroMechanical Systems) based technology and SiC-based semiconductor technology. The hardware and software allows control and interrocation of each sensor head and reduces accompanying cabling through multiplexing. These systems are being, applied on the X-33 and on an upcoming STS-95 Shuttle mission. A number of commercial applications are also being pursued. It is concluded that this MEMS-based technology has significant potential to reduce costs and increase safety in a variety of aerospace applications.

  7. Toward An Affordable Commercial Fuel Cell (LBNL Summer Lecture Series)

    ScienceCinema

    Visco, Steve [Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States). Materials Sciences Division

    2018-02-16

    Steve Visco, a materials scientist, has come up with a solid oxide fuel cell that promises to generate electricity as cheaply as the most efficient gas turbine engine. But there's a lot more work to do before commercially viable fuel cells and pollution-free power generators become reality.

  8. Assessment of the commercial viability of selected options for on-orbit servicing (OOS)

    NASA Astrophysics Data System (ADS)

    Graham, Andrew Robert; Kingston, Jennifer

    2015-12-01

    The aim of this paper is to determine the commercial viability of on-orbit servicing of communications satellites in geostationary orbit. Previous studies have shown the technical feasibility of servicing as well as the financial viability of some missions, in particular refuelling, therefore this paper analyses these repair missions and life extension missions. A simple parametric model for simulating communications satellite revenue streams is developed and the results are used to determine the maximum possible revenue for a servicing satellite operator. From this, the maximum cost of the servicing satellite as a proportion of the cost of the communications satellite is determined under three profit scenarios representing zero profit, acceptable profit to an operator in a mature industry and acceptable profit to an operator in an emerging industry. The results show that while servicing is financially viable (zero profit scenario), those missions which result in an increase in Comsat life which is a multiple of the mission duration are more likely to be commercially viable. Refuelling is therefore viable in all cases but life extension in most cases is only marginally viable. Repair missions to satellites which are partially operable are also unlikely to deliver sufficient value to justify carrying out servicing. Also the timing of a servicing mission in relation to the expected remaining life expectancy is a major factor in determining the mission's viability.

  9. Enumeration of viable and non-viable larvated Ascaris eggs with quantitative PCR

    EPA Science Inventory

    Aims: The goal of the study was to further develop an incubation-qPCR method for quantifying viable Ascaris eggs. The specific objectives were to characterize the detection limit and number of template copies per egg, determine the specificity of the method, and test the method w...

  10. An experimental study of potential residential and commercial applications of small-scale hybrid power systems

    NASA Astrophysics Data System (ADS)

    Acosta, Michael Anthony

    The research presented in this thesis provides an understanding of small-scale hybrid power systems. Experiments were conducted to identify potential applications of renewable energy in residential and commercial applications in the Rio Grande Valley of Texas. Solar and wind energy converted into electric energy was stored in batteries and inverted to power common household and commercial appliances. Several small to medium size hybrid power systems were setup and utilized to conduct numerous tests to study renewable energy prospects and feasibility for various applications. The experimental results obtained indicate that carefully constructed solar power systems can provide people living in isolated communities with sufficient energy to consistently meet their basic power needs.

  11. US EPA Base Study Standard Operating Procedure for Sampling and Characterization of Viable and Non-Viable Bioaerosols in Indoor Air

    EPA Pesticide Factsheets

    The objective of the procedure is to collect a representative sample concentration of total airborne fungal spores (viable and non-viable) that may be present in indoor air and in the outdoor air supplied to the space tested.

  12. Guideline for the utilization of commercial grade items in nuclear safety related applications: Final report. [Contains Glossary

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Tulay, M.P.; Yurich, F.J.; Schremser, F.M. Jr.

    1988-06-01

    This guideline provides direction for the procurement and use of Commercial Grade Items (CGI)in safety-related applications. It is divided into five major sections. A glossary of terms and definitions, an acronym listing, and seven appendices have been included. The glossary defines terms used in this guideline. In certain instances, the definitions may be unique to this guideline. Identification of acronyms utilized in this guideline is also provided. Section 1 provides a background of the commercial grade item issues facing the nuclear industry. It provides a historical perspective of commercial grade item issues. Section 2 discusses the generic process for themore » acceptance of a commercial grade item for safety-related use. Section 3 defines the four distinct methods used to accept commercial grade items for safety-related applications. Section 4 lists specific references that are identified in this guideline. Section 5 is a bibliography of documents that were considered in developed this guideline, but were not directly referenced in the document.« less

  13. Neuroscience: viable applications in education?

    PubMed

    Devonshire, Ian M; Dommett, Eleanor J

    2010-08-01

    As a relatively young science, neuroscience is still finding its feet in potential collaborations with other disciplines. One such discipline is education, with the field of neuroeducation being on the horizon since the 1960s. However, although its achievements are now growing, the partnership has not been as successful as first hopes suggested it should be. Here the authors discuss the theoretical barriers and potential solutions to this, which have been suggested previously, with particular focus on levels of research in neuroscience and their applicability to education. Moreover, they propose that these theoretical barriers are driven and maintained by practical barriers surrounding common language and research literacy. They propose that by overcoming these practical barriers through appropriate training and shared experience, neuroeducation can reach its full potential.

  14. Present and Future Applications of Digital Electronics in Nuclear Science - a Commercial Prospective

    NASA Astrophysics Data System (ADS)

    Tan, Hui

    2011-10-01

    Digital readout electronics instrumenting radiation detectors have experienced significant advancements in the last decade or so. This on one hand can be attributed to the steady improvements in commercial digital processing components such as analog-to-digital converters (ADCs), digital-to-analog converters (DACs), field-programmable-gate-arrays (FPGAs), and digital-signal-processors (DSPs), and on the other hand can also be attributed to the increasing needs for improved time, position, and energy resolution in nuclear physics experiments, which have spurred the rapid development of commercial off-the-shelf high speed, high resolution digitizers or spectrometers. Absent from conventional analog electronics, the capability to record fast decaying pulses from radiation detectors in digital readout electronics has profoundly benefited nuclear physics researchers since they now can perform detailed pulse processing for applications such as gamma-ray tracking and decay-event selection and reconstruction. In this talk, present state-of-the-art digital readout electronics and its applications in a variety of nuclear science fields will be discussed, and future directions in hardware development for digital electronics will also be outlined, all from the prospective of a commercial manufacturer of digital electronics.

  15. A combination of direct viable count and fluorescence in situ hybridization for specific enumeration of viable Lactobacillus delbrueckii subsp.bulgaricus and Streptococcus thermophilus.

    PubMed

    García-Hernández, J; Moreno, Y; Amorocho, C M; Hernández, M

    2012-03-01

    We have developed a direct viable count (DVC)-FISH procedure for quickly and easily discriminating between viable and nonviable cells of Lactobacillus delbrueckii subsp. bulgaricus and Streptococcus thermophilus strains, the traditional yogurt bacteria. direct viable count method has been modified and adapted for Lact. delbrueckii subsp. bulgaricus and Strep. thermophilus analysis by testing different times of incubation and concentrations of DNA-gyrase inhibitors. DVC procedure has been combined with fluorescent in situ hybridization (FISH) for the specific detection of viable cells of both bacteria with specific rRNA oligonucleotide probes (DVC-FISH). Of the four antibiotics tested (novobiocin, nalidixic acid, pipemidic acid and ciprofloxacin), novobiocin was the most effective for DVC method and the optimum incubation time was 7 h for both bacteria. The number of viable cells was obtained by the enumeration of specific hybridized cells that were elongated at least twice their original length for Lactobacillus and twice their original size for Streptococcus. This technique was successfully applied to detect viable cells in inoculated faeces. Results showed that this DVC-FISH procedure is a quick and culture-independent useful method to specifically detect viable Lact. delbrueckii subsp. bulgaricus and Strep. thermophilus in different samples, being applied for the first time to lactic acid bacteria. © 2011 The Authors. Letters in Applied Microbiology © 2011 The Society for Applied Microbiology.

  16. Quantification of viable and non-viable Legionella spp. by heterogeneous asymmetric recombinase polymerase amplification (haRPA) on a flow-based chemiluminescence microarray.

    PubMed

    Kober, Catharina; Niessner, Reinhard; Seidel, Michael

    2018-02-15

    Increasing numbers of legionellosis outbreaks within the last years have shown that Legionella are a growing challenge for public health. Molecular biological detection methods capable of rapidly identifying viable Legionella are important for the control of engineered water systems. The current gold standard based on culture methods takes up to 10 days to show positive results. For this reason, a flow-based chemiluminescence (CL) DNA microarray was developed that is able to quantify viable and non-viable Legionella spp. as well as Legionella pneumophila in one hour. An isothermal heterogeneous asymmetric recombinase polymerase amplification (haRPA) was carried out on flow-based CL DNA microarrays. Detection limits of 87 genomic units (GU) µL -1 and 26GUµL -1 for Legionella spp. and Legionella pneumophila, respectively, were achieved. In this work, it was shown for the first time that the combination of a propidium monoazide (PMA) treatment with haRPA, the so-called viability haRPA, is able to identify viable Legionella on DNA microarrays. Different proportions of viable and non-viable Legionella, shown with the example of L. pneumophila, ranging in a total concentration between 10 1 to 10 5 GUµL -1 were analyzed on the microarray analysis platform MCR 3. Recovery values for viable Legionella spp. were found between 81% and 133%. With the combination of these two methods, there is a chance to replace culture-based methods in the future for the monitoring of engineered water systems like condensation recooling plants. Copyright © 2017 Elsevier B.V. All rights reserved.

  17. Soluble Factors Released by Endogenous Viable Cells Enhance the Antioxidant and Chemoattractive Activities of Cryopreserved Amniotic Membrane

    PubMed Central

    Duan-Arnold, Yi; Gyurdieva, Alexandra; Johnson, Amy; Jacobstein, Douglas A.; Danilkovitch, Alla

    2015-01-01

    Objective: Regulation of oxidative stress and recruitment of key cell types are activities of human amniotic membrane (hAM) that contribute to its benefits for wound treatment. Progress in tissue preservation has led to commercialization of hAM. The majority of hAM products are devitalized with various degrees of matrix alteration. Data show the importance of hAM matrix preservation, but little is known about the advantages of retaining viable endogenous cells. In this study, we compared the antioxidant and chemoattractive properties of viable intact cryopreserved hAM (int-hAM) and devitalized cryopreserved hAM (dev-hAM) to determine the benefits of cell preservation. Approach: We evaluated the ability of int-hAM and dev-hAM to protect fibroblasts from oxidant-induced cell damage, to suppress oxidants, and to recruit fibroblasts and keratinocytes in vitro. Results: Both the int-hAM–derived conditioned medium (CM) and the int-hAM tissue rescued significantly more fibroblasts from oxidant-induced damage than dev-hAM (844% and 93% more, respectively). The int-hAM CM showed a 202% greater antioxidant capacity than dev-hAM. The int-hAM CM enhanced the recruitment of fibroblasts and normal and diseased keratinocytes to a greater extent than dev-hAM (1,555%, 315%, and 151% greater, respectively). Innovation and Conclusion: Int-hAM, in which all native components are preserved, including endogenous viable cells, demonstrated a significantly greater antioxidant and fibroblast and keratinocyte chemoattractive potential compared to dev-hAM, in which viable cells are destroyed. The release of soluble factors that protect fibroblasts from oxidative injury by hAM containing viable cells is a mechanism of hAM antioxidant activity, which is a novel finding of this study. PMID:26029483

  18. Re-Purposing Commercial Entertainment Software for Military Use

    DTIC Science & Technology

    2000-09-01

    and simulation needs of the military can be awkward or impossible. Video games are designed to be both technologically advanced and flexible in design...We evaluated current games and modified Quake 3 Arena(Q3A) to serve as both an architectural walkthrough and a primitive team trainer. To accomplish...weapons models and characteristics, and overall game play. By re-purposing commercial entertainment software, we have produced a viable military virtual

  19. Commercial grade item (CGI) dedication of MDR relays for nuclear safety related applications

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Das, R.K.; Julka, A.; Modi, G.

    1994-08-01

    MDR relays manufactured by Potter and Brumfield (P and B) have been used in various safety related applications in commercial nuclear power plants. These include emergency safety features (ESF) actuation systems, emergency core cooling systems (ECCS) actuation, and reactor protection systems. The MDR relays manufactured prior to May 1990 showed signs of generic failure due to corrosion and outgassing of coil varnish. P and B has made design changes to correct these problems in relays manufactured after May 1990. However, P and B does not manufacture the relays under any 10CFR50 Appendix B quality assurance (QA) program. They manufacture themore » relays under their commercial QA program and supply these as commercial grade items. This necessitates CGI Dedication of these relays for use in nuclear-safety-related applications. This paper presents a CGI dedication program that has been used to dedicate the MDR relays manufactured after May 1990. The program is in compliance with current Nuclear Regulatory Commission (NRC) and Electric Power Research Institute (EPRI) guidelines and applicable industry standards; it specifies the critical characteristics of the relays, provides the tests and analysis required to verify the critical characteristics, the acceptance criteria for the test results, performs source verification to qualify P and B for its control of the critical characteristics, and provides documentation. The program provides reasonable assurance that the new MDR relays will perform their intended safety functions.« less

  20. Integrated vehicle control and guidance systems in unmanned ground vehicles for commercial applications

    NASA Astrophysics Data System (ADS)

    Kenyon, Chase H.

    1995-01-01

    While there is a lot of recent development in the entire IVHS field, very few have had the opportunity to combine the many areas of development into a single integrated `intelligent' unmanned vehicle. One of our systems was developed specifically to serve a major automobile manufacturer's need for an automated vehicle chassis durability test facility. Due to the severity of the road surface human drivers could not be used. A totally automated robotic vehicle driver and guidance system was necessary. In order to deliver fixed price commercial projects now, it was apparent system and component costs were of paramount importance. Cyplex has developed a robust, cost effective single wire guidance system. This system has inherent advantages in system simplicity. Multi-signal (per vehicle lane) systems complicate path planning and layout when multiple lanes and lane changes are required, as on actual highways. The system has demonstrated high enough immunity to rain and light snow cover that normal safety reductions in speed are adequate to stay within the required system performance envelope. This system and it's antenna interface have shown the ability to guide the vehicle at slow speeds (10 MPH) with a tracking repeatability of plus or minus 1/8 of an inch. The basic guide and antenna system has been tested at speeds up to 80 mph. The system has inherently superior abilities for lane changes and precision vehicle placement. The operation of this system will be described and the impact of a system that is commercially viable now for highway and off road use will be discussed.

  1. Commercial Aircraft Pricing: Application of Lessons Learned

    DTIC Science & Technology

    2017-12-01

    competitive sources are not relevant. The Institute for Defense Analyses (IDA) has performed a series of studies developing estimating relationships...for the prices of commercial aircraft, variants of which figure in DoD acquisition programs.1 Commercial aircraft that are used for the basis of...military systems are examples of commercial items sold in markets dominated by sellers with market power where competitive sourcing may not be

  2. Optimizatin of sugarcane factory application of Commercial Dextranases in the U.S.

    USDA-ARS?s Scientific Manuscript database

    Although the use of commercial dextranases to break down dextran in sugar manufacture was pioneered by Australian researchers in the 1970s, applications in the U.S. sugar industry are still not optimized. This is partly because of misinformation about where to add the enzyme and which enzyme to use....

  3. Preliminary Evaluation Of Commercial Supercapacitors For Space Applications

    NASA Astrophysics Data System (ADS)

    Gineste, Valery; Loup, Didier; Mattesco, Patrick; Neugnot, Nicolas

    2011-10-01

    Supercapacitors are identified since years as a new technology enabling energy storage together with high power delivery capability to the system. A recent ESA study [1] led by Astrium has demonstrated the interest of these devices for space application, providing that reliability and end of life performances are demonstrated. A realistic commercial on the shelf (COTS) approach (or with limited design modification approved by potential suppliers) has been favoured (as for batteries). This paper presents preliminary test results done by Astrium on COTS supercapacitors: accelerated life tests, calendar life tests, technology analyses. Based on these results, assessment and lessons learnt are drawn in view of future exhaustive supercapacitor validation and future qualification.

  4. CASH 2021: commercial access and space habitation.

    PubMed

    Aldrin, Andrew; Amara, Adam; Aris, Lodewijk; Baierl, Nida; Beatty, Patrick; Beaulieu, Catherine; Behnke, Torsten; Castegini, Roberta; Chauhan, Amitabh; Cojanis, Philip; Dayawansa, Pelawa; Diop, Marie; Eito, Kinya; Engle, Steve; Feretti, Stefano; Gassama, Hamet; Genova, Bojana; Goulding, Colin; Janjua, Jameel; Jansaeng, Thidarat; Jousset, Frederic; Kopik, Anatoly; Laurin, Catherine; Leggatt, Jason; Li, Hengnian; Mezzadri, Monica; Miura, Amane; Nolet, Simon; Ogami, Satoshi; Patry, Johanne; Patten, Laryssa; Payerne, Cyril; Peer, Guy; Prampolini, Marco; Rheaume, Caroline; Saary, Joan; Spehar, Daniela; Sufi, Atiya; Sun, Baosheng; Thompson, J Barry; Thomson, Ward; Trautner, Roland; Tursunmuratov, Murat; Venet, Vrata; Wilems, Elizabeth; Wilson, Helen; Wittwer, Karl; Wokke, Frank; Wu, Yansheng; Zhou, Shaobin; Zilioli, Ilaria

    2002-01-01

    Issues about commercialization of space have been a growing concern in the past decade for the space community. This paper focuses on the work from a team of 51 students attending the Summer Session Program of the International Space University in Bremen, Germany. CASH 2021 (Commercial Access and Space Habitation) documents a plan that identifies commercial opportunities for space utilization that will extend human presence in space, and will chart the way forward for the next 20 years. The group selected four commercial sectors that show the most promise for the future: tourism, entertainment, space system service, assembly and debris removal, and research and development/production. The content of this document presents the results of their research. Historical activities in each of the commercial sectors are reviewed along with the current market situation. To provide a coherent background for future commercialization possibilities a scenario has been developed. This scenario includes a postulated upon ideal future and includes social, political and economic factors that may affect the space industry over the timeline of the study. The study also presents a roadmap, within the limited optimistic scenario developed, for the successful commercialization of space leading to future human presence in space. A broad range of commercially viable opportunities, not only within the current limits of the International Space Station, but also among the many new developments that are expected by 2021 are discussed. c2002 International Astronautical Federation. Published by Elsevier Science Ltd. All rights reserved.

  5. Marine Carotenoids: Biological Functions and Commercial Applications

    PubMed Central

    Vílchez, Carlos; Forján, Eduardo; Cuaresma, María; Bédmar, Francisco; Garbayo, Inés; Vega, José M.

    2011-01-01

    Carotenoids are the most common pigments in nature and are synthesized by all photosynthetic organisms and fungi. Carotenoids are considered key molecules for life. Light capture, photosynthesis photoprotection, excess light dissipation and quenching of singlet oxygen are among key biological functions of carotenoids relevant for life on earth. Biological properties of carotenoids allow for a wide range of commercial applications. Indeed, recent interest in the carotenoids has been mainly for their nutraceutical properties. A large number of scientific studies have confirmed the benefits of carotenoids to health and their use for this purpose is growing rapidly. In addition, carotenoids have traditionally been used in food and animal feed for their color properties. Carotenoids are also known to improve consumer perception of quality; an example is the addition of carotenoids to fish feed to impart color to farmed salmon. PMID:21556162

  6. NASA commercial programs

    NASA Technical Reports Server (NTRS)

    1988-01-01

    An expanded role for the U.S. private sector in America's space future has emerged as a key national objective, and NASA's Office of Commercial Programs is providing a focus for action. The Office supports new high technology commercial space ventures, the commercial application of existing aeronautics and space technology, and expanded commercial access to available NASA capabilities and services. The progress NASA has made in carrying out its new assignment is highlighted.

  7. Commercial Earth Observation

    NASA Technical Reports Server (NTRS)

    1995-01-01

    Through the Earth Observation Commercial Applications Program (EOCAP) at Stennis Space Center, Applied Analysis, Inc. developed a new tool for analyzing remotely sensed data. The Applied Analysis Spectral Analytical Process (AASAP) detects or classifies objects smaller than a pixel and removes the background. This significantly enhances the discrimination among surface features in imagery. ERDAS, Inc. offers the system as a modular addition to its ERDAS IMAGINE software package for remote sensing applications. EOCAP is a government/industry cooperative program designed to encourage commercial applications of remote sensing. Projects can run three years or more and funding is shared by NASA and the private sector participant. Through the Earth Observation Commercial Applications Program (EOCAP), Ocean and Coastal Environmental Sensing (OCENS) developed SeaStation for marine users. SeaStation is a low-cost, portable, shipboard satellite groundstation integrated with vessel catch and product monitoring software. Linked to the Global Positioning System, SeaStation provides real time relationships between vessel position and data such as sea surface temperature, weather conditions and ice edge location. This allows the user to increase fishing productivity and improve vessel safety. EOCAP is a government/industry cooperative program designed to encourage commercial applications of remote sensing. Projects can run three years or more and funding is shared by NASA and the private sector participant.

  8. The technology and commercial status of powder-injection molding

    NASA Astrophysics Data System (ADS)

    Bose, Animesh

    1995-08-01

    The process of powder-injection molding (PIM) is a viable and competitive commercial technique that is being used to process complex-shaped parts of various materials in moderate to high volumes. The hey advantage of the process is its unique ability to combine materials selection flexibility with the complex shape-forming ability of plastics. Although the PIM process has been discussed in the open literature for more than quarter of a century, it has become a commercial reality only during the last decade or so. Currently, there is a tremendous interest in this unique technology throughout the world. As a result, the PIM industry is poised for significant growth.

  9. The development of nickel-metal hydride technology for use in aerospace applications

    NASA Technical Reports Server (NTRS)

    Rampel, Guy; Johnson, Herschel; Dell, Dan; Wu, Tony; Puglisi, Vince

    1992-01-01

    The nickel metal hydride technology for battery application is relatively immature even though this technology was made widely known by Philips' scientists as long ago as 1970. Recently, because of the international environmental regulatory pressures being placed on cadmium in the workplace and in disposal practices, battery companies have initiated extensive development programs to make this technology a viable commercial operation. These hydrides do not pose a toxilogical threat as does cadmium. Also, they provide a higher energy density and specific energy when compared to the other nickel based battery technologies. For these reasons, the nickel metal hydride electrochemisty is being evaluated as the next power source for varied applications such as laptop computers, cellular telephones, electric vehicles, and satellites. A parallel development effort is under way to look at aerospace applications for nickel metal hydride cells. This effort is focused on life testing of small wound cells of the commercial type to validate design options and development of prismatic design cells for aerospace applications.

  10. Potential Commercial Applications from Combustion and Fire Research in Space

    NASA Technical Reports Server (NTRS)

    Friedman, Robert; Lyons, Valerie J.

    1996-01-01

    The near-zero (microgravity) environment of orbiting spacecraft minimizes buoyant flows, greatly simplifying combustion processes and isolating important phenomena ordinarily concealed by the overwhelming gravity-driven forces and flows. Fundamental combustion understanding - the focus to date of the NASA microgravity-combustion program - has greatly benefited from analyses and experiments conducted in the microgravity environment. Because of the economic and commercial importance of combustion in practice, there is strong motivation to seek wider applications for the microgravity-combustion findings. This paper reviews selected technology developments to illustrate some emerging applications. Topics cover improved fire-safety technology in spacecraft and terrestrial systems, innovative combustor designs for aerospace and ground propulsion, applied sensors and controls for combustion processes, and self-sustaining synthesis techniques for advanced materials.

  11. Performance measures in the earth observations commercialization applications program

    NASA Astrophysics Data System (ADS)

    Macauley, Molly K.

    1996-03-01

    Performance measures in the Earth Observations Commercialization Application Program (EOCAP) are key to its success and include net profitability; enhancements to industry productivity through generic innovations in industry practices, standards, and protocols; and documented contributions to public policy governing the newly developing remote sensing industry. Because EOCAP requires company co-funding, both parties to the agreement (the government and the corporate partner) have incentives to pursue these goals. Further strengthening progress towards these goals are requirements for business plans in the company's EOCAP proposal, detailed scrutiny given these plans during proposal selection, and regularly documented progress reports during project implementation.

  12. Commercial applications of telemedicine

    NASA Technical Reports Server (NTRS)

    Natiello, Thomas A.

    1991-01-01

    Telemedicine Systems Corporation was established in 1976 and is a private commercial supplier of telemedicine systems. These systems are various combinations of communications and diagnostic technology, designed to allow the delivery of health care services to remote facilities. The technology and the health care services are paid for by the remote facilities, such as prisons.

  13. Commercial launch systems: A risky investment?

    NASA Astrophysics Data System (ADS)

    Dupnick, Edwin; Skratt, John

    1996-03-01

    A myriad of evolutionary paths connect the current state of government-dominated space launch operations to true commercial access to space. Every potential path requires the investment of private capital sufficient to fund the commercial venture with a perceived risk/return ratio acceptable to the investors. What is the private sector willing to invest? Does government participation reduce financial risk? How viable is a commercial launch system without government participation and support? We examine the interplay between various forms of government participation in commercial launch system development, alternative launch system designs, life cycle cost estimates, and typical industry risk aversion levels. The boundaries of this n-dimensional envelope are examined with an ECON-developed business financial model which provides for the parametric assessment and interaction of SSTO design variables (including various operational scenarios with financial variables including debt/equity assumptions, and commercial enterprise burden rates on various functions. We overlay this structure with observations from previous ECON research which characterize financial risk aversion levels for selected industrial sectors in terms of acceptable initial lump-sum investments, cumulative investments, probability of failure, payback periods, and ROI. The financial model allows the construction of parametric tradeoffs based on ranges of variables which can be said to actually encompass the ``true'' cost of operations and determine what level of ``true'' costs can be tolerated by private capitalization.

  14. Commercial applications of satellite oceanography

    NASA Technical Reports Server (NTRS)

    Montgomery, D. R.

    1981-01-01

    It is shown that in the next decade the oceans' commercial users will require an operational oceanographic satellite system or systems capable of maximizing real-time coverage over all ocean areas. Seasat studies suggest that three spacecraft are required to achieve this. Here, the sensor suite would measure surface winds, wave heights (and spectral energy distribution), ice characteristics, sea-surface temperature, ocean colorimetry, height of the geoid, salinity, and subsurface thermal structure. The importance of oceanographic data being distributed to commercial users within two hours of observation time is stressed. Also emphasized is the importance of creating a responsive oceanographic satellite data archive. An estimate of the potential dollar benefits of such an operational oceanographic satellite system is given.

  15. Application study of filamentary composites in a commercial jet aircraft fuselage

    NASA Technical Reports Server (NTRS)

    Johnson, R. W.; June, R. R.

    1972-01-01

    A study of applications of filamentary composite materials to aircraft fuselage structure was performed. General design criteria were established and material studies conducted using the 727-200 forebody as the primary structural component. Three design approaches to the use of composites were investigated: uniaxial reinforcement of metal structure, uniaxial and biaxial reinforcement of metal structure, and an all-composite design. Materials application studies for all three concepts were conducted on fuselage shell panels, keel beam, floor beams, floor panels, body frames, fail-safe straps, and window frames. Cost benefit studies were conducted and developmental program costs estimated. On the basis of weight savings, cost effectiveness, developmental program costs, and potential for early application on commercial aircraft, the unaxial design is recommended for a 5-year flight service evaluation program.

  16. Commercial Radio as Communication.

    ERIC Educational Resources Information Center

    Rothenbuhler, Eric W.

    1996-01-01

    Compares the day-to-day work routines of commercial radio with the principles of a theoretical communication model. Illuminates peculiarities of the conduct of communication by commercial radio. Discusses the application of theoretical models to the evaluation of practicing institutions. Offers assessments of commercial radio deriving from…

  17. Deploying a Route Optimization EFB Application for Commercial Airline Operational Trials

    NASA Technical Reports Server (NTRS)

    Roscoe, David A.; Vivona, Robert A.; Woods, Sharon E.; Karr, David A.; Wing, David J.

    2016-01-01

    The Traffic Aware Planner (TAP), developed for NASA Langley Research Center to support the Traffic Aware Strategic Aircrew Requests (TASAR) project, is a flight-efficiency software application developed for an Electronic Flight Bag (EFB). Tested in two flight trials and planned for operational testing by two commercial airlines, TAP is a real-time trajectory optimization application that leverages connectivity with onboard avionics and broadband Internet sources to compute and recommend route modifications to flight crews to improve fuel and time performance. The application utilizes a wide range of data, including Automatic Dependent Surveillance Broadcast (ADS-B) traffic, Flight Management System (FMS) guidance and intent, on-board sensors, published winds and weather, and Special Use Airspace (SUA) schedules. This paper discusses the challenges of developing and deploying TAP to various EFB platforms, our solutions to some of these challenges, and lessons learned, to assist commercial software developers and hardware manufacturers in their efforts to implement and extend TAP functionality in their environments. EFB applications (such as TAP) typically access avionics data via an ARINC 834 Simple Text Avionics Protocol (STAP) server hosted by an Aircraft Interface Device (AID) or other installed hardware. While the protocol is standardized, the data sources, content, and transmission rates can vary from aircraft to aircraft. Additionally, the method of communicating with the AID may vary depending on EFB hardware and/or the availability of onboard networking services, such as Ethernet, WIFI, Bluetooth, or other mechanisms. EFBs with portable and installed components can be implemented using a variety of operating systems, and cockpits are increasingly incorporating tablet-based technologies, further expanding the number of platforms the application may need to support. Supporting multiple EFB platforms, AIDs, avionics datasets, and user interfaces presents a

  18. Amperometric IFN-γ immunosensors with commercially fabricated PCB sensing electrodes.

    PubMed

    Moschou, Despina; Greathead, Louise; Pantelidis, Panagiotis; Kelleher, Peter; Morgan, Hywel; Prodromakis, Themistoklis

    2016-12-15

    Lab-on-a-Chip (LoC) technology has the potential to revolutionize medical Point-of-Care diagnostics. Currently, considerable research efforts are focused on innovative production technologies that will make commercial upscaling of lab-on-chip products financially viable. Printed circuit board (PCB) manufacturing techniques have several advantages in this field. In this paper we focus on transferring a complete IFN-γ enzyme-linked immune-sorbent assay (ELISA) onto a commercial PCB electrochemical biosensing platform, We adapted a commercially available ELISA to detect the enzyme product TMB/H2O2 using amperometry, successfully reproducing the colorimetry-obtained ELISA standard curve. The results demonstrate the potential for the integration of these components into an automated, disposable, electronic ELISA Lab-on-PCB diagnostic platform. Copyright © 2016 Elsevier B.V. All rights reserved.

  19. Trends in genetic patent applications: the commercialization of academic intellectual property.

    PubMed

    Kers, Jannigje G; Van Burg, Elco; Stoop, Tom; Cornel, Martina C

    2014-10-01

    We studied trends in genetic patent applications in order to identify the trends in the commercialization of research findings in genetics. To define genetic patent applications, the European version (ECLA) of the International Patent Classification (IPC) codes was used. Genetic patent applications data from the PATSTAT database from 1990 until 2009 were analyzed for time trends and regional distribution. Overall, the number of patent applications has been growing. In 2009, 152 000 patent applications were submitted under the Patent Cooperation Treaty (PCT) and within the EP (European Patent) system of the European Patent Office (EPO). The number of genetic patent applications increased until a peak was reached in the year 2000, with >8000 applications, after which it declined by almost 50%. Continents show different patterns over time, with the global peak in 2000 mainly explained by the USA and Europe, while Asia shows a stable number of >1000 per year. Nine countries together account for 98.9% of the total number of genetic patent applications. In The Netherlands, 26.7% of the genetic patent applications originate from public research institutions. After the year 2000, the number of genetic patent applications dropped significantly. Academic leadership and policy as well as patent regulations seem to have an important role in the trend differences. The ongoing investment in genetic research in the past decade is not reflected by an increase of patent applications.

  20. Fluorescence particle detector for real-time quantification of viable organisms in air

    NASA Astrophysics Data System (ADS)

    Luoma, Greg; Cherrier, Pierre P.; Piccioni, Marc; Tanton, Carol; Herz, Steve; DeFreez, Richard K.; Potter, Michael; Girvin, Kenneth L.; Whitney, Ronald

    2002-02-01

    The ability to detect viable organisms in air in real time is important in a number of applications. Detecting high levels of airborne organisms in hospitals can prevent post-operative infections and the spread of diseases. Monitoring levels of airborne viable organisms in pharmaceutical facilities can ensure safe production of drugs or vaccines. Monitoring airborne bacterial levels in meat processing plants can help to prevent contamination of food products. Monitoring the level of airborne organisms in bio-containment facilities can ensure that proper procedures are being followed. Finally, detecting viable organisms in real time is a key to defending against biological agent attacks. This presentation describes the development and performance of a detector, based on fluorescence particle counting technology, where an ultraviolet laser is used to count particles by light scattering and elicit fluorescence from specific biomolecules found only in living organisms. The resulting detector can specifically detect airborne particles containing living organisms from among the large majority of other particles normally present in air. Efforts to develop the core sensor technology, focusing on integrating an UV laser with a specially designed particle-counting cell will be highlighted. The hardware/software used to capture the information from the sensor, provide an alarm in the presence of an unusual biological aerosol content will also be described. Finally, results from experiments to test the performance of the detector will be presented.

  1. Grazing of particle-associated bacteria-an elimination of the non-viable fraction.

    PubMed

    Gonsalves, Maria-Judith; Fernandes, Sheryl Oliveira; Priya, Madasamy Lakshmi; LokaBharathi, Ponnapakkam Adikesavan

    Quantification of bacteria being grazed by microzooplankton is gaining importance since they serve as energy subsidies for higher trophic levels which consequently influence fish production. Hence, grazing pressure on viable and non-viable fraction of free and particle-associated bacteria in a tropical estuary controlled mainly by protist grazers was estimated using the seawater dilution technique. In vitro incubations over a period of 42h showed that at the end of 24h, growth coefficient (k) of particle-associated bacteria was 9 times higher at 0.546 than that of free forms. Further, 'k' value of viable cells on particles was double that of free forms at 0.016 and 0.007, respectively. While bacteria associated with particles were grazed (coefficient of removal (g)=0.564), the free forms were relatively less grazed indicating that particle-associated bacteria were exposed to grazers in these waters. Among the viable and non-viable forms, 'g' of non-viable fraction (particle-associated bacteria=0.615, Free=0.0086) was much greater than the viable fraction (particle-associated bacteria=0.056, Free=0.068). Thus, grazing on viable cells was relatively low in both the free and attached states. These observations suggest that non-viable forms of particle-associated bacteria were more prone to grazing and were weeded out leaving the viable cells to replenish the bacterial standing stock. Particle colonization could thus be a temporary refuge for the "persistent variants" where the viable fraction multiply and release their progeny. Copyright © 2016 Sociedade Brasileira de Microbiologia. Published by Elsevier Editora Ltda. All rights reserved.

  2. Commercial applications and scientific research requirements for thermal-infrared observations of terrestrial surfaces

    NASA Technical Reports Server (NTRS)

    Goward, Samuel N.; Taranik, James V.; Laporte, Daniel; Putnam, Evelyn S. (Editor)

    1986-01-01

    In the spring of 1986 the EOSAT Company and NASA Headquarters organized a workshop to consider: (1) the potential value of space-acquired multiband thermal remote sensing in terrestrial research and commercial applications, and (2) the scientific and technological requirements for conducting such observations from the LANDSAT platform. The workshop defined the instrument characteristics of three types of sensors that would be needed to expand the use of thermal information for Earth observation and new commercial opportunities. The panels from two disciplines, geology and evapotranspiration/botany, along with the instrument panel, presented their recommendations to the workshop. The findings of these meetings are presented.

  3. A remote sensing applications update: Results of interviews with Earth Observations Commercialization Program (EOCAP) participants

    NASA Technical Reports Server (NTRS)

    Mcvey, Sally

    1991-01-01

    Earth remote sensing is a uniquely valuable tool for large-scale resource management, a task whose importance will likely increase world-wide through the foreseeable future. NASA research and engineering have virtually created the existing U.S. system, and will continue to push the frontiers, primarily through Earth Observing System (EOS) instruments, research, and data and information systems. It is the researchers' view that the near-term health of remote sensing applications also deserves attention; it seems important not to abandon the system or its clients. The researchers suggest that, like its Landsat predecessor, a successful Earth Observing System program is likely to reinforce pressure to 'manage' natural resources, and consequently, to create more pressure for Earth Observations Commercialization (EOCAP) type applications. The current applications programs, though small, are valuable because of their technical and commercial results, and also because they support a community whose contributions will increase along with our ability to observe the Earth from space.

  4. Space Commercialization

    NASA Technical Reports Server (NTRS)

    Martin, Gary L.

    2011-01-01

    A robust and competitive commercial space sector is vital to continued progress in space. The United States is committed to encouraging and facilitating the growth of a U.S. commercial space sector that supports U.S. needs, is globally competitive, and advances U.S. leadership in the generation of new markets and innovation-driven entrepreneurship. Energize competitive domestic industries to participate in global markets and advance the development of: satellite manufacturing; satellite-based services; space launch; terrestrial applications; and increased entrepreneurship. Purchase and use commercial space capabilities and services to the maximum practical extent Actively explore the use of inventive, nontraditional arrangements for acquiring commercial space goods and services to meet United States Government requirements, including measures such as public-private partnerships, . Refrain from conducting United States Government space activities that preclude, discourage, or compete with U.S. commercial space activities. Pursue potential opportunities for transferring routine, operational space functions to the commercial space sector where beneficial and cost-effective.

  5. Trace detection of specific viable bacteria using tetracysteine-tagged bacteriophages.

    PubMed

    Wu, Lina; Luan, Tian; Yang, Xiaoting; Wang, Shuo; Zheng, Yan; Huang, Tianxun; Zhu, Shaobin; Yan, Xiaomei

    2014-01-07

    Advanced methods are urgently needed to determine the identity and viability of trace amounts of pathogenic bacteria in a short time. Existing approaches either fall short in the accurate assessment of microbial viability or lack specificity in bacterial identification. Bacteriophages (or phages for short) are viruses that exclusively infect bacterial host cells with high specificity. As phages infect and replicate only in living bacterial hosts, here we exploit the strategy of using tetracysteine (TC)-tagged phage in combination with biarsenical dye to the discriminative detection of viable target bacteria from dead target cells and other viable but nontarget bacterial cells. Using recombinant M13KE-TC phage and Escherichia coli ER2738 as a model system, distinct differentiation between individual viable target cells from dead target cells was demonstrated by flow cytometry and fluorescence microscopy. As few as 1% viable E. coli ER2738 can be accurately quantified in a mix with dead E. coli ER2738 by flow cytometry. With fluorescence microscopic measurement, specific detection of as rare as 1 cfu/mL original viable target bacteria was achieved in the presence of a large excess of dead target cells and other viable but nontarget bacterial cells in 40 mL artificially contaminated drinking water sample in less than 3 h. This TC-phage-FlAsH approach is sensitive, specific, rapid, and simple, and thus shows great potential in water safety monitoring, health surveillance, and clinical diagnosis of which trace detection and identification of viable bacterial pathogens is highly demanded.

  6. MOSES: a modular sensor electronics system for space science and commercial applications

    NASA Astrophysics Data System (ADS)

    Michaelis, Harald; Behnke, Thomas; Tschentscher, Matthias; Mottola, Stefano; Neukum, Gerhard

    1999-10-01

    The camera group of the DLR--Institute of Space Sensor Technology and Planetary Exploration is developing imaging instruments for scientific and space applications. One example is the ROLIS imaging system of the ESA scientific space mission `Rosetta', which consists of a descent/downlooking and a close-up imager. Both are parts of the Rosetta-Lander payload and will operate in the extreme environment of a cometary nucleus. The Rosetta Lander Imaging System (ROLIS) will introduce a new concept for the sensor electronics, which is referred to as MOSES (Modula Sensor Electronics System). MOSES is a 3D miniaturized CCD- sensor-electronics which is based on single modules. Each of the modules has some flexibility and enables a simple adaptation to specific application requirements. MOSES is mainly designed for space applications where high performance and high reliability are required. This concept, however, can also be used in other science or commercial applications. This paper describes the concept of MOSES, its characteristics, performance and applications.

  7. Space Environment Stability and Physical Properties of New Materials for Space Power and Commercial Applications

    NASA Technical Reports Server (NTRS)

    Hambourger, Paul D.

    1997-01-01

    To test and evaluate suitability of materials for use in space power systems and related space and commercial applications, and to achieve sufficient understanding of the mechanisms by which, the materials perform in their intended applications. Materials and proposed applications included but were not limited to: Improved anodes for lithium ion batteries, highly-transparent arc-proof solar array coatings, and improved surface materials for solar dynamic concentrators and receivers. Cooperation and interchange of data with industrial companies as appropriate.

  8. Trends in genetic patent applications: the commercialization of academic intellectual property

    PubMed Central

    Kers, Jannigje G; Van Burg, Elco; Stoop, Tom; Cornel, Martina C

    2014-01-01

    We studied trends in genetic patent applications in order to identify the trends in the commercialization of research findings in genetics. To define genetic patent applications, the European version (ECLA) of the International Patent Classification (IPC) codes was used. Genetic patent applications data from the PATSTAT database from 1990 until 2009 were analyzed for time trends and regional distribution. Overall, the number of patent applications has been growing. In 2009, 152 000 patent applications were submitted under the Patent Cooperation Treaty (PCT) and within the EP (European Patent) system of the European Patent Office (EPO). The number of genetic patent applications increased until a peak was reached in the year 2000, with >8000 applications, after which it declined by almost 50%. Continents show different patterns over time, with the global peak in 2000 mainly explained by the USA and Europe, while Asia shows a stable number of >1000 per year. Nine countries together account for 98.9% of the total number of genetic patent applications. In The Netherlands, 26.7% of the genetic patent applications originate from public research institutions. After the year 2000, the number of genetic patent applications dropped significantly. Academic leadership and policy as well as patent regulations seem to have an important role in the trend differences. The ongoing investment in genetic research in the past decade is not reflected by an increase of patent applications. PMID:24448546

  9. Transferring diffractive optics from research to commercial applications: Part II - size estimations for selected markets

    NASA Astrophysics Data System (ADS)

    Brunner, Robert

    2014-04-01

    In a series of two contributions, decisive business-related aspects of the current process status to transfer research results on diffractive optical elements (DOEs) into commercial solutions are discussed. In part I, the focus was on the patent landscape. Here, in part II, market estimations concerning DOEs for selected applications are presented, comprising classical spectroscopic gratings, security features on banknotes, DOEs for high-end applications, e.g., for the semiconductor manufacturing market and diffractive intra-ocular lenses. The derived market sizes are referred to the optical elements, itself, rather than to the enabled instruments. The estimated market volumes are mainly addressed to scientifically and technologically oriented optical engineers to serve as a rough classification of the commercial dimensions of DOEs in the different market segments and do not claim to be exhaustive.

  10. Illinois Pesticide Applicator Study Guide. A Training Manual for Private and Commercial Pesticide Applicators and Operators. Special Publication 39.

    ERIC Educational Resources Information Center

    Bever, Wayne; And Others

    This study guide is designed to provide the necessary information to prepare for certification as a private or commercial pesticide applicator. In addition to providing basic information covering the various sections of the amended Federal Insecticide, Fungicide, and Rodenticide Act, it contains a glossary of common pesticide terms, a list of…

  11. SP-100 nuclear space power systems with application to space commercialization

    NASA Technical Reports Server (NTRS)

    Smith, John M.

    1988-01-01

    The purpose of this paper is to familiarize the Space Commercialization Community with the status and characteristics of the SP-100 space nuclear power system. The program is a joint undertaking by the Department of Defense, the Department of Energy and NASA. The goal of the program is to develop, validate, and demonstrate the technology for space nuclear power systems in the range of 10 to 1000 kWe electric for use in the future civilian and military space missions. Also discussed are mission applications which are enhanced and/or enabled by SP-100 technology and how this technology compares to that of more familiar solar power systems. The mission applications include earth orbiting platforms and lunar/Mars surface power.

  12. Fuel cell power plants for automotive applications

    NASA Astrophysics Data System (ADS)

    McElroy, J. F.

    1983-02-01

    While the Solid Polymer Electrolyte (SPE) fuel cell has until recently not been considered competitive with such commercial and industrial energy systems as gas turbine generators and internal combustion engines, electrical current density improvements have markedly improved the capital cost/kW output rating performance of SPE systems. Recent studies of SPE fuel cell applicability to vehicular propulsion have indicated that with adequate development, a powerplant may be produced which will satisfy the performance, size and weight objectives required for viable electric vehicles, and that the cost for such a system would be competitive with alternative advanced power systems.

  13. Economically Viable Components from Jerusalem Artichoke (Helianthus tuberosus L.) in a Biorefinery Concept

    PubMed Central

    Johansson, Eva; Prade, Thomas; Angelidaki, Irini; Svensson, Sven-Erik; Newson, William R.; Gunnarsson, Ingólfur Bragi; Persson Hovmalm, Helena

    2015-01-01

    Biorefinery applications are receiving growing interest due to climatic and waste disposal issues and lack of petroleum resources. Jerusalem artichoke (Helianthus tuberosus L.) is suitable for biorefinery applications due to high biomass production and limited cultivation requirements. This paper focuses on the potential of Jerusalem artichoke as a biorefinery crop and the most viable products in such a case. The carbohydrates in the tubers were found to have potential for production of platform chemicals, e.g., succinic acid. However, economic analysis showed that production of platform chemicals as a single product was too expensive to be competitive with petrochemically produced sugars. Therefore, production of several products from the same crop is a must. Additional products are protein based ones from tubers and leaves and biogas from residues, although both are of low value and amount. High bioactive activity was found in the young leaves of the crop, and the sesquiterpene lactones are of specific interest, as other compounds from this group have shown inhibitory effects on several human diseases. Thus, future focus should be on understanding the usefulness of small molecules, to develop methods for their extraction and purification and to further develop sustainable and viable methods for the production of platform chemicals. PMID:25913379

  14. Regulation of Viable and Optimal Cohorts

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Aubin, Jean-Pierre, E-mail: aubin.jp@gmail.com

    This study deals with the evolution of (scalar) attributes (resources or income in evolutionary demography or economics, position in traffic management, etc.) of a population of “mobiles” (economic agents, vehicles, etc.). The set of mobiles sharing the same attributes is regarded as an instantaneous cohort described by the number of its elements. The union of instantaneous cohorts during a mobile window between two attributes is a cohort. Given a measure defining the number of instantaneous cohorts, the accumulation of the mobile attributes on a evolving mobile window is the measure of the cohort on this temporal mobile window. Imposing accumulationmore » constraints and departure conditions, this study is devoted to the regulation of the evolutions of the attributes which are1.viable in the sense that the accumulations constraints are satisfied at each instant;2.and, among them, optimal, in the sense that both the duration of the temporal mobile window is maximum and that the accumulation on this temporal mobile window is the largest viable one. This value is the “accumulation valuation” function. Viable and optimal evolutions under accumulation constraints are regulated by an “implicit Volterra integro-differential inclusion” built from the accumulation valuation function, solution to an Hamilton–Jacobi–Bellman partial differential equation under constraints which is constructed for this purpose.« less

  15. Economically viable large-scale hydrogen liquefaction

    NASA Astrophysics Data System (ADS)

    Cardella, U.; Decker, L.; Klein, H.

    2017-02-01

    The liquid hydrogen demand, particularly driven by clean energy applications, will rise in the near future. As industrial large scale liquefiers will play a major role within the hydrogen supply chain, production capacity will have to increase by a multiple of today’s typical sizes. The main goal is to reduce the total cost of ownership for these plants by increasing energy efficiency with innovative and simple process designs, optimized in capital expenditure. New concepts must ensure a manageable plant complexity and flexible operability. In the phase of process development and selection, a dimensioning of key equipment for large scale liquefiers, such as turbines and compressors as well as heat exchangers, must be performed iteratively to ensure technological feasibility and maturity. Further critical aspects related to hydrogen liquefaction, e.g. fluid properties, ortho-para hydrogen conversion, and coldbox configuration, must be analysed in detail. This paper provides an overview on the approach, challenges and preliminary results in the development of efficient as well as economically viable concepts for large-scale hydrogen liquefaction.

  16. Viable Blastocystis Cysts in Scottish and Malaysian Sewage Samples

    PubMed Central

    Suresh, K.; Smith, H. V.; Tan, T. C.

    2005-01-01

    Blastocystis cysts were detected in 38% (47/123) (37 Scottish, 17 Malaysian) of sewage treatment works. Fifty percent of influents (29% Scottish, 76% Malaysian) and 28% of effluents (9% Scottish, 60% Malaysian) contained viable cysts. Viable cysts, discharged in effluent, provide further evidence for the potential for waterborne transmission of Blastocystis. PMID:16151162

  17. A lightweight, high strength dexterous manipulator for commercial applications

    NASA Technical Reports Server (NTRS)

    Marzwell, Neville I.; Schena, Bruce M.; Cohan, Steve M.

    1991-01-01

    The concept, design, and features are described of a lightweight, high strength, modular robot manipulator being developed for space and commercial applications. The manipulator has seven fully active degrees of freedom and is fully operational in 1 G. Each of the seven joints incorporates a unique drivetrain design which provides zero backlash operation, is insensitive to wear, and is single fault tolerant to motor or servo amplifier failure. Feedback sensors provide position, velocity, torque, and motor winding temperature information at each joint. This sensing system is also designed to be single fault tolerant. The manipulator consists of five modules (not including gripper). These modules join via simple quick-disconnect couplings and self-mating connectors which allow rapid assembly and/or disassembly for reconfiguration, transport, or servicing. The manipulator is a completely enclosed assembly, with no exposed components or wires. Although the initial prototype will not be space qualified, the design is well suited to meeting space requirements. The control system provides dexterous motion by controlling the endpoint location and arm pose simultaneously. Potential applications are discussed.

  18. Commercial-off-the-shelf (COTS) hardware and software for train control applications : system safety considerations.

    DOT National Transportation Integrated Search

    2003-04-01

    The objective of this study was to assess the feasibility of using commercial off-the-shelf(COTS)processor-based systems for safety- related railroad applications. From the safety perspective,the fundamental challenges of using COTS products are most...

  19. PMA-Linked Fluorescence for Rapid Detection of Viable Bacterial Endospores

    NASA Technical Reports Server (NTRS)

    LaDuc, Myron T.; Venkateswaran, Kasthuri; Mohapatra, Bidyut

    2012-01-01

    The most common approach for assessing the abundance of viable bacterial endospores is the culture-based plating method. However, culture-based approaches are heavily biased and oftentimes incompatible with upstream sample processing strategies, which make viable cells/spores uncultivable. This shortcoming highlights the need for rapid molecular diagnostic tools to assess more accurately the abundance of viable spacecraft-associated microbiota, perhaps most importantly bacterial endospores. Propidium monoazide (PMA) has received a great deal of attention due to its ability to differentiate live, viable bacterial cells from dead ones. PMA gains access to the DNA of dead cells through compromised membranes. Once inside the cell, it intercalates and eventually covalently bonds with the double-helix structures upon photoactivation with visible light. The covalently bound DNA is significantly altered, and unavailable to downstream molecular-based manipulations and analyses. Microbiological samples can be treated with appropriate concentrations of PMA and exposed to visible light prior to undergoing total genomic DNA extraction, resulting in an extract comprised solely of DNA arising from viable cells. This ability to extract DNA selectively from living cells is extremely powerful, and bears great relevance to many microbiological arenas.

  20. Intracellular integration of synthetic nanostructures with viable cells for controlled biochemical manipulation

    NASA Astrophysics Data System (ADS)

    McKnight, Timothy E.; Melechko, Anatoli V.; Griffin, Guy D.; Guillorn, Michael A.; Merkulov, Vladimir I.; Serna, Francisco; Hensley, Dale K.; Doktycz, Mitchel J.; Lowndes, Douglas H.; Simpson, Michael L.

    2003-05-01

    We demonstrate the integration of vertically aligned carbon nanofibre (VACNF) elements with the intracellular domains of viable cells for controlled biochemical manipulation. Deterministically synthesized VACNFs were modified with either adsorbed or covalently-linked plasmid DNA and were subsequently inserted into cells. Post insertion viability of the cells was demonstrated by continued proliferation of the interfaced cells and long-term (> 22 day) expression of the introduced plasmid. Adsorbed plasmids were typically desorbed in the intracellular domain and segregated to progeny cells. Covalently bound plasmids remained tethered to nanofibres and were expressed in interfaced cells but were not partitioned into progeny, and gene expression ceased when the nanofibre was no longer retained. This provides a method for achieving a genetic modification that is non-inheritable and whose extent in time can be directly and precisely controlled. These results demonstrate the potential of VACNF arrays as an intracellular interface for monitoring and controlling subcellular and molecular phenomena within viable cells for applications including biosensors, in vivo diagnostics, and in vivo logic devices.

  1. 75 FR 8181 - Commercial Driver's License Standards: Application for Exemption; Volvo Trucks North America (Volvo)

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-02-23

    ... DEPARTMENT OF TRANSPORTATION Federal Motor Carrier Safety Administration [Docket No. FMCSA-2006... (Volvo) AGENCY: Federal Motor Carrier Safety Administration (FMCSA), DOT. ACTION: Notice of application...) has applied for an exemption from the Federal requirement for a driver of commercial motor vehicles...

  2. 75 FR 2921 - Commercial Driver's License Standards: Application for Exemption; Volvo Trucks North America (Volvo)

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-01-19

    ... DEPARTMENT OF TRANSPORTATION Federal Motor Carrier Safety Administration [Docket No. FMCSA-2006... (Volvo) AGENCY: Federal Motor Carrier Safety Administration (FMCSA), DOT. ACTION: Notice of application...) has applied for an exemption from the Federal requirement for a driver of commercial motor vehicles...

  3. Biocatalytically active silCoat-composites entrapping viable Escherichia coli.

    PubMed

    Findeisen, A; Thum, O; Ansorge-Schumacher, M B

    2014-02-01

    Application of whole cells in industrial processes requires high catalytic activity, manageability, and viability under technical conditions, which can in principle be accomplished by appropriate immobilization. Here, we report the identification of carrier material allowing exceptionally efficient adsorptive binding of Escherichia coli whole cells hosting catalytically active carbonyl reductase from Candida parapsilosis (CPCR2). With the immobilizates, composite formation with both hydrophobic and hydrophilized silicone was achieved, yielding advanced silCoat-material and HYsilCoat-material, respectively. HYsilCoat-whole cells were viable preparations with a cell loading up to 400 mg(E. coli) · g(-1)(carrier) and considerably lower leaching than native immobilizates. SilCoat-whole cells performed particularly well in neat substrate exhibiting distinctly increased catalytic activity.

  4. A perspective on early commercial applications of voice-processing technology for telecommunications and aids for the handicapped.

    PubMed Central

    Seelbach, C

    1995-01-01

    The Colloquium on Human-Machine Communication by Voice highlighted the global technical community's focus on the problems and promise of voice-processing technology, particularly, speech recognition and speech synthesis. Clearly, there are many areas in both the research and development of these technologies that can be advanced significantly. However, it is also true that there are many applications of these technologies that are capable of commercialization now. Early successful commercialization of new technology is vital to ensure continuing interest in its development. This paper addresses efforts to commercialize speech technologies in two markets: telecommunications and aids for the handicapped. PMID:7479814

  5. Economic benefits of commercial space activities

    NASA Astrophysics Data System (ADS)

    Stone, Barbara A.

    Space is not only an endless frontier for exploration, but also a potentially rich arena for profitable commerce to benefit all mankind. Access to the unique environment of space provides opportunities for unprecedented kinds of research to develop new products and services. This research can lead to commercially viable enterprises, which will become permanent businesses, which will provide good jobs for workers, pay taxes to their governments, and return dividends to their investors. Seeking superior products and processes is vital if the economy is to grow and prosper. This paper discusses the current and potential impact on the economy of selected private sector space activities.

  6. Commercial viability of CNS drugs: balancing the risk/reward profile.

    PubMed

    Johnson, Ginger S

    2014-01-01

    CNS has historically been a formidable therapeutic area in which to innovate owing to biological (e.g., complex neurobiology, difficulty reaching the target), as well as clinical (e.g., subjective clinical endpoints, high placebo response, lack of biomarkers) challenges. In the current market where many of the larger diseases are dominated by a generic standard of care, commercial challenges now make the triple threat of scientific-clinical-commercial risk too much for many players to tackle. However, opportunities do exist for smaller biotech companies to concentrate on narrowly focused patient populations associated with high unmet need for which risk can be tightly defined. In CNS, there are two major areas to balance the risk/reward profile and create commercially viable opportunities: To realize value, all companies (start-ups and big players) must define, measure and quantify clear and meaningful value to all stakeholders: physicians, patients, caregivers and payers. © 2013.

  7. Survival of genetically modified and self-cloned strains of commercial baker's yeast in simulated natural environments: environmental risk assessment.

    PubMed

    Ando, Akira; Suzuki, Chise; Shima, Jun

    2005-11-01

    Although genetic engineering techniques for baker's yeast might improve the yeast's fermentation characteristics, the lack of scientific data on the survival of such strains in natural environments as well as the effects on human health prevent their commercial use. Disruption of acid trehalase gene (ATH1) improves freeze tolerance, which is a crucial characteristic in frozen-dough baking. In this study, ATH1 disruptants constructed by genetic modification (GM) and self-cloning (SC) techniques were used as models to study such effects because these strains have higher freeze tolerance and are expected to be used commercially. Behavior of the strains in simulated natural environments, namely, in soil and water, was studied by measuring the change in the number of viable cells and in the concentration of DNA that contains ATH1 loci. Measurements were made using a real-time PCR method during 40 days of cultivation. Results showed that the number of viable cells of GM and SC strains decreased in a time-dependent manner and that the decrease rate was nearly equal to or higher than that for wild-type (WT) yeast. For all three strains (SC, GM, and WT) in the two simulated natural environments (water and soil), the DNA remained longer than did viable cells but the decrease patterns of either the DNA or the viable cells of SC and GM strains had tendencies similar to those of the WT strain. In conclusion, disruption of ATH1 by genetic engineering apparently does not promote the survival of viable cells and DNA in natural environments.

  8. Regenerative Fuel Cell System Testbed Program for Government and Commercial Applications

    NASA Technical Reports Server (NTRS)

    1996-01-01

    NASA Lewis Research Center's Electrochemical Technology Branch has led a multiagency effort to design, fabricate, and operate a regenerative fuel cell (RFC) system testbed. Key objectives of this program are to evaluate, characterize, and demonstrate fully integrated RFC's for space, military, and commercial applications. The Lewis-led team is implementing the program through a unique international coalition that encompasses both Government and industry participants. Construction of the 25-kW RFC testbed at the NASA facility at Edwards Air Force Base was completed in January 1995, and the system has been operational since that time.

  9. Where is the café? The challenge of making retail uses viable in mixed-use suburban developments.

    PubMed

    Grant, Jill; Perrott, Katherine

    2011-01-01

    Contemporary planners see mixing residential, retail and other compatible uses as an essential planning principle. This paper explores the challenges that planners, developers and municipal councillors encounter in trying to implement retail uses as part of the mix in suburban areas in three Canadian cities. The study finds that planners employ evolutionary theories of urban development to naturalise their normative visions of walkable and sociable communities. By contrast, developers point to consumer behaviour to explain why planners' ideas on mix do not work. In a society where people shop at big-box outlets, making the local café or pub commercially viable proves increasingly challenging.

  10. Commercial Smartphone-Based Devices and Smart Applications for Personalized Healthcare Monitoring and Management.

    PubMed

    Vashist, Sandeep Kumar; Schneider, E Marion; Luong, John H T

    2014-08-18

    Smartphone-based devices and applications (SBDAs) with cost effectiveness and remote sensing are the most promising and effective means of delivering mobile healthcare (mHealthcare). Several SBDAs have been commercialized for the personalized monitoring and/or management of basic physiological parameters, such as blood pressure, weight, body analysis, pulse rate, electrocardiograph, blood glucose, blood glucose saturation, sleeping and physical activity. With advances in Bluetooth technology, software, cloud computing and remote sensing, SBDAs provide real-time on-site analysis and telemedicine opportunities in remote areas. This scenario is of utmost importance for developing countries, where the number of smartphone users is about 70% of 6.8 billion cell phone subscribers worldwide with limited access to basic healthcare service. The technology platform facilitates patient-doctor communication and the patients to effectively manage and keep track of their medical conditions. Besides tremendous healthcare cost savings, SBDAs are very critical for the monitoring and effective management of emerging epidemics and food contamination outbreaks. The next decade will witness pioneering advances and increasing applications of SBDAs in this exponentially growing field of mHealthcare. This article provides a critical review of commercial SBDAs that are being widely used for personalized healthcare monitoring and management.

  11. Detection of Only Viable Bacterial Spores Using a Live/Dead Indicator in Mixed Populations

    NASA Technical Reports Server (NTRS)

    Behar, Alberto E.; Stam, Christina N.; Smiley, Ronald

    2013-01-01

    This method uses a photoaffinity label that recognizes DNA and can be used to distinguish populations of bacterial cells from bacterial spores without the use of heat shocking during conventional culture, and live from dead bacterial spores using molecular-based methods. Biological validation of commercial sterility using traditional and alternative technologies remains challenging. Recovery of viable spores is cumbersome, as the process requires substantial incubation time, and the extended time to results limits the ability to quickly evaluate the efficacy of existing technologies. Nucleic acid amplification approaches such as PCR (polymerase chain reaction) have shown promise for improving time to detection for a wide range of applications. Recent real-time PCR methods are particularly promising, as these methods can be made at least semi-quantitative by correspondence to a standard curve. Nonetheless, PCR-based methods are rarely used for process validation, largely because the DNA from dead bacterial cells is highly stable and hence, DNA-based amplification methods fail to discriminate between live and inactivated microorganisms. Currently, no published method has been shown to effectively distinguish between live and dead bacterial spores. This technology uses a DNA binding photoaffinity label that can be used to distinguish between live and dead bacterial spores with detection limits ranging from 109 to 102 spores/mL. An environmental sample suspected of containing a mixture of live and dead vegetative cells and bacterial endospores is treated with a photoaffinity label. This step will eliminate any vegetative cells (live or dead) and dead endospores present in the sample. To further determine the bacterial spore viability, DNA is extracted from the spores and total population is quantified by real-time PCR. The current NASA standard assay takes 72 hours for results. Part of this procedure requires a heat shock step at 80 degC for 15 minutes before the

  12. Use of Viable Cryopreserved Umbilical Tissue for Soft Tissue Defects in Patients With Gas Gangrene: A Case Series.

    PubMed

    McGinness, Kristen; Kurtz Phelan, Dorothy H

    2018-04-01

    Gas gangrene is a rapidly progressive bacterial infection leading to necrosis that usually develops as a result of trauma or postoperative complications. This condition requires early diagnosis with immediate surgical intervention. With a poor prognosis, a high incidence of amputation, and comorbidities such as diabetes and peripheral vascular disease, patients with gas gangrene are put at further risk for surgical complications. This case series reports the clinical outcomes of using a commercially available viable cryopreserved umbilical tissue (vCUT) in the surgical management of 10 patients (9 males, 1 female) with acute lower extremity gas gangrene. All 10 patients had aggressive debridement and irrigation, followed by an intraoperative application of vCUT to cover the large, complex wounds with exposed bone, tendon, and soft tissue, which was fenestrated and sutured to the surrounding skin edges. The average wound size following debridement was 45.9 cm2 (range, 8 cm2-105 cm2). Average percent area reduction of the wounds at 4 weeks post-vCUT application was 68.4% (range, 49%-99.5%). The average length of hospital stay was 9 days (range, 2-16 days), and postdischarge patients were treated with negative pressure wound therapy and standard of care (nonadherent dressing, dry gauze, and mild compression) until wound closure was achieved (average, 3.3 months [range, 1.25-4.5 months]). With a 1-time application of vCUT, all patients reached complete wound closure with decreased time to closure, fewer complications, and a shorter duration of hospitalization as compared with traditional inpatient management of gas gangrene (incision and drainage with staged procedures). The positive clinical outcomes indicate that vCUT may be an effective aid as an intraoperative application to cover wounds following aggressive debridement in the presence of gas gangrene.

  13. 48 CFR 212.570 - Applicability of certain laws to contracts and subcontracts for the acquisition of commercially...

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ..., DEPARTMENT OF DEFENSE ACQUISITION PLANNING ACQUISITION OF COMMERCIAL ITEMS Applicability of Certain Laws to.... 2533b, Requirement to buy strategic materials critical to national security from American sources, is...

  14. 48 CFR 212.570 - Applicability of certain laws to contracts and subcontracts for the acquisition of commercially...

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ..., DEPARTMENT OF DEFENSE ACQUISITION PLANNING ACQUISITION OF COMMERCIAL ITEMS Applicability of Certain Laws to.... 2533b, Requirement to buy strategic materials critical to national security from American sources, is...

  15. Caltech/JPL Conference on Image Processing Technology, Data Sources and Software for Commercial and Scientific Applications

    NASA Technical Reports Server (NTRS)

    Redmann, G. H.

    1976-01-01

    Recent advances in image processing and new applications are presented to the user community to stimulate the development and transfer of this technology to industrial and commercial applications. The Proceedings contains 37 papers and abstracts, including many illustrations (some in color) and provides a single reference source for the user community regarding the ordering and obtaining of NASA-developed image-processing software and science data.

  16. Development of CMOS Active Pixel Image Sensors for Low Cost Commercial Applications

    NASA Technical Reports Server (NTRS)

    Fossum, E.; Gee, R.; Kemeny, S.; Kim, Q.; Mendis, S.; Nakamura, J.; Nixon, R.; Ortiz, M.; Pain, B.; Zhou, Z.; hide

    1994-01-01

    This paper describes ongoing research and development of CMOS active pixel image sensors for low cost commercial applications. A number of sensor designs have been fabricated and tested in both p-well and n-well technologies. Major elements in the development of the sensor include on-chip analog signal processing circuits for the reduction of fixed pattern noise, on-chip timing and control circuits and on-chip analog-to-digital conversion (ADC). Recent results and continuing efforts in these areas will be presented.

  17. Recent Work in Hybrid Radiation Transport Methods with Applications to Commercial Nuclear Power

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Kulesza, Joel A.

    This talk will begin with an overview of hybrid radiation transport methods followed by a discussion of the author’s work to advance current capabilities. The talk will then describe applications for these methods in commercial nuclear power reactor analyses and techniques for experimental validation. When discussing these analytical and experimental activities, the importance of technical standards such as those created and maintained by ASTM International will be demonstrated.

  18. Application of Reverse Transcriptase -PCR (RT-PCR) for rapid detection of viable Escherichia coli in drinking water samples.

    PubMed

    Molaee, Neda; Abtahi, Hamid; Ghannadzadeh, Mohammad Javad; Karimi, Masoude; Ghaznavi-Rad, Ehsanollah

    2015-01-01

    Polymerase chain reaction (PCR) is preferred to other methods for detecting Escherichia coli (E. coli) in water in terms of speed, accuracy and efficiency. False positive result is considered as the major disadvantages of PCR. For this reason, reverse transcriptase-polymerase chain reaction (RT-PCR) can be used to solve this problem. The aim of present study was to determine the efficiency of RT-PCR for rapid detection of viable Escherichia coli in drinking water samples and enhance its sensitivity through application of different filter membranes. Specific primers were designed for 16S rRNA and elongation Factor II genes. Different concentrations of bacteria were passed through FHLP and HAWP filters. Then, RT-PCR was performed using 16srRNA and EF -Tu primers. Contamination of 10 wells was determined by RT-PCR in Arak city. To evaluate RT-PCR efficiency, the results were compared with most probable number (MPN) method. RT-PCR is able to detect bacteria in different concentrations. Application of EF II primers reduced false positive results compared to 16S rRNA primers. The FHLP hydrophobic filters have higher ability to absorb bacteria compared with HAWB hydrophilic filters. So the use of hydrophobic filters will increase the sensitivity of RT-PCR. RT-PCR shows a higher sensitivity compared to conventional water contamination detection method. Unlike PCR, RT-PCR does not lead to false positive results. The use of EF-Tu primers can reduce the incidence of false positive results. Furthermore, hydrophobic filters have a higher ability to absorb bacteria compared to hydrophilic filters.

  19. Commercialization of NASA's High Strength Cast Aluminum Alloy for High Temperature Applications

    NASA Technical Reports Server (NTRS)

    Lee, Jonathan A.

    2003-01-01

    In this paper, the commercialization of a new high strength cast aluminum alloy, invented by NASA-Marshall Space Flight Center, for high temperature applications will be presented. Originally developed to meet U.S. automotive legislation requiring low- exhaust emission, the novel NASA aluminum alloy offers dramatic improvement in tensile and fatigue strengths at elevated temperatures (450 F-750 F), which can lead to reducing part weight and cost as well as improving performance for automotive engine applications. It is an ideal low cost material for cast components such as pistons, cylinder heads, cylinder liners, connecting rods, turbo chargers, impellers, actuators, brake calipers and rotors. NASA alloy also offers greater wear resistance, dimensional stability, and lower thermal expansion compared to conventional aluminum alloys, and the new alloy can be produced economically from sand, permanent mold and investment casting. Since 2001, this technology was licensed to several companies for automotive and marine internal combustion engines applications.

  20. Commercial Smartphone-Based Devices and Smart Applications for Personalized Healthcare Monitoring and Management

    PubMed Central

    Vashist, Sandeep Kumar; Schneider, E. Marion; Luong, John H.T.

    2014-01-01

    Smartphone-based devices and applications (SBDAs) with cost effectiveness and remote sensing are the most promising and effective means of delivering mobile healthcare (mHealthcare). Several SBDAs have been commercialized for the personalized monitoring and/or management of basic physiological parameters, such as blood pressure, weight, body analysis, pulse rate, electrocardiograph, blood glucose, blood glucose saturation, sleeping and physical activity. With advances in Bluetooth technology, software, cloud computing and remote sensing, SBDAs provide real-time on-site analysis and telemedicine opportunities in remote areas. This scenario is of utmost importance for developing countries, where the number of smartphone users is about 70% of 6.8 billion cell phone subscribers worldwide with limited access to basic healthcare service. The technology platform facilitates patient-doctor communication and the patients to effectively manage and keep track of their medical conditions. Besides tremendous healthcare cost savings, SBDAs are very critical for the monitoring and effective management of emerging epidemics and food contamination outbreaks. The next decade will witness pioneering advances and increasing applications of SBDAs in this exponentially growing field of mHealthcare. This article provides a critical review of commercial SBDAs that are being widely used for personalized healthcare monitoring and management. PMID:26852680

  1. Computers for Manned Space Applications Base on Commercial Off-the-Shelf Components

    NASA Astrophysics Data System (ADS)

    Vogel, T.; Gronowski, M.

    2009-05-01

    Similar to the consumer markets there has been an ever increasing demand in processing power, signal processing capabilities and memory space also for computers used for science data processing in space. An important driver of this development have been the payload developers for the International Space Station, requesting high-speed data acquisition and fast control loops in increasingly complex systems. Current experiments now even perform video processing and compression with their payload controllers. Nowadays the requirements for a space qualified computer are often far beyond the capabilities of, for example, the classic SPARC architecture that is found in ERC32 or LEON CPUs. An increase in performance usually demands costly and power consuming application specific solutions. Continuous developments over the last few years have now led to an alternative approach that is based on complete electronics modules manufactured for commercial and industrial customers. Computer modules used in industrial environments with a high demand for reliability under harsh environmental conditions like chemical reactors, electrical power plants or on manufacturing lines are entered into a selection procedure. Promising candidates then undergo a detailed characterisation process developed by Astrium Space Transportation. After thorough analysis and some modifications, these modules can replace fully qualified custom built electronics in specific, although not safety critical applications in manned space. This paper focuses on the benefits of COTS1 based electronics modules and the necessary analyses and modifications for their utilisation in manned space applications on the ISS. Some considerations regarding overall systems architecture will also be included. Furthermore this paper will also pinpoint issues that render such modules unsuitable for specific tasks, and justify the reasons. Finally, the conclusion of this paper will advocate the implementation of COTS based

  2. Comments on the commercialization of expendable launch vehicles

    NASA Technical Reports Server (NTRS)

    Trilling, D. R.

    1984-01-01

    The President's national space policy encourages private sector investment and involvement in civil space activities. Last November, the President designated the Department of Transportation as lead agency for the commercialization of expendable launch vehicles. This presents a substantial challenge to the United States Government, since the guidelines and requirements that are set now will have great influence on whether American firms can become a viable competitive industry in the world launch market. There is a dual need to protect public safety and free the private sector launch industry from needless regulatory barriers so that it can grow and prosper.

  3. sCO2 Brayton Cycle: Roadmap to sCO2 Power Cycles NE Commercial Applications.

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Mendez Cruz, Carmen Margarita; Rochau, Gary E.

    The mission of the Energy Conversion (EC) area of the Advanced Reactor Technology (ART) program is to commercialize the sCO2 Brayton cycle for Advance Reactors and for the Supercritical Transformational Electric Production (STEP) program. The near-term objective of the EC team efforts is to support the development of a commercially scalable Recompression Closed Brayton Cycle (RCBC) to be constructed for the first STEP demonstration system with the lowest risk possible. This document details the status of technology, policy and market considerations, documentation of gaps and needs, and outlines the steps necessary for the successful development and deployment of commercial sCO2more » Brayton Power Systems along the path to nuclear reactor applications. Document Control Version Creation Date Revisions Created By Release Date 1.0 2/29/2016 Preliminary Draft Mendez, C. 3/2/2016 2.0 7/29/2016 Preliminaty/Partial Report -- updated Focus Area structure, added commercial path forward Mendez, C. 8/10/16 3.0 5/1/2018 Updated Roadmap supports timeline changes and inclusion of grid qualification goals Mendez, C. 6/6/18« less

  4. Commercial potential of space-based plant research

    NASA Astrophysics Data System (ADS)

    Bula, Raymond J.; Christophersen, Eric

    1999-01-01

    Plant research conducted in space by commercial organizations could enhance the development of plant materials having superior characteristics and unique constituents for a wide range of agricultural, industrial, and medical applications. These commercial efforts will also include terrestrial application of controlled environment technologies that reduce the time involved in making the new plant materials available in the marketplace. The International Space Station with its ability to support long duration plant experiments will be critically important to such commercial activities.

  5. Translation of an experimental oral vaccine formulation into a commercial product.

    PubMed

    Carter, K C; Ferro, V A; Alexander, J; Mullen, A B

    2006-02-01

    An effective experimental vaccine may fail to become a therapeutic reality for a number of scientific, regulatory or commercial reasons. In this review, we share some of our personal experiences as University-based researchers and provide an account of some of the problems that we have encountered during preliminary scale-up and assessment of an oral influenza vaccine formulation. Many of the problems we have faced have been non-scientific and related to identifying project-funding sources, finding suitable contract manufacturing companies that are GMP compliant, and protecting intellectual property generated from the scientific studies. The review is intended as a practical guide that will allow other researchers to adopt effective strategies to permit the translation of an effective experimental formulation to a viable commercial product.

  6. Cariogenicity induced by commercial carbonated beverages in an experimental biofilm-caries model

    PubMed Central

    Giacaman, Rodrigo A.; Pailahual, Vanesa; Díaz-Garrido, Natalia

    2018-01-01

    Objectives: Frequent consumption of sugars-containing carbonated beverages has been associated with caries, but the consequences on the dental biofilm remain unclear. The aim was to evaluate the effect of commercial carbonated beverages and their sugar-free version on enamel and dentine demineralization and on the cariogenic properties of Streptococcus mutans biofilms. Materials and Methods: Biofilms of S. mutans UA159 were grown on enamel and dentin slabs and exposed 3 times/day for 5 min, to a commercial cola or orange-flavored carbonated beverage or to their sugar-free version. Biofilms/slabs were recovered to assess biomass, viable microorganisms, protein content and polysaccharides. Demineralization was estimated by the variation of Knoop surface microhardness. Results: Exposures to the biofilm with sugars-containing carbonated beverages resulted in similar biomass, viable microorganisms, proteins, and polysaccharides than sucrose (P < 0.05). The sugar-free cola and orange-flavored drink showed lower effect on the biofilm, as compared with sucrose or their sugared version (P < 0.05). All of the products tested, included the sugar-free, showed higher demineralization than the negative control (P < 0.05). Conclusions: Sugars-containing carbonated beverages enhance cariogenic activity of S. mutans biofilms, comparable with sucrose. Sugar-free carbonated beverages also have a high demineralizing potential, without affecting biofilm properties. PMID:29657522

  7. Microbial assessment of cabin air quality on commercial airliners

    NASA Technical Reports Server (NTRS)

    La Duc, Myron T.; Stuecker, Tara; Bearman, Gregory; Venkateswaran, Kasthuri

    2005-01-01

    The microbial burdens of 69 cabin air samples collected from commercial airliners were assessed via conventional culture-dependent, and molecular-based microbial enumeration assays. Cabin air samples from each of four separate flights aboard two different carriers were collected via air-impingement. Microbial enumeration techniques targeting DNA, ATP, and endotoxin were employed to estimate total microbial burden. The total viable microbial population ranged from 0 to 3.6 x10 4 cells per 100 liters of air, as assessed by the ATP-assay. When these same samples were plated on R2A minimal medium, anywhere from 2% to 80% of these viable populations were cultivable. Five of the 29 samples examined exhibited higher cultivable counts than ATP derived viable counts, perhaps a consequence of the dormant nature (and thus lower concentration of intracellular ATP) of cells inhabiting these air cabin samples. Ribosomal RNA gene sequence analysis showed these samples to consist of a moderately diverse group of bacteria, including human pathogens. Enumeration of ribosomal genes via quantitative-PCR indicated that population densities ranged from 5 x 10 1 ' to IO 7 cells per 100 liters of air. Each of the aforementioned strategies for assessing overall microbial burden has its strengths and weaknesses; this publication serves as a testament to the power of their use in concert.

  8. Rhinitis Associated with Pesticide Exposure among Commercial Pesticide Applicators in the Agricultural Health Study

    PubMed Central

    Slager, Rebecca E.; Poole, Jill A.; LeVan, Tricia D.; Sandler, Dale P.; Alavanja, Michael C. R.; Hoppin, Jane A.

    2010-01-01

    Objectives Rhinitis is common, but the risk factors are not well described. To investigate the association between current rhinitis and pesticide use, we used data from 2,245 Iowa commercial pesticide applicators in the Agricultural Health Study. Methods Using logistic regression models adjusted for age, education, and growing up on a farm, we evaluated the association between current rhinitis and 34 pesticides used in the past year. Results Seventy-four percent of commercial pesticide applicators reported at least one episode of rhinitis in the past year (current rhinitis). Five pesticides used in the past year were significantly positively associated with current rhinitis: the herbicides 2,4-D, glyphosate and petroleum oil, the insecticide diazinon and the fungicide benomyl. The association for 2,4-D and glyphosate was limited to individuals who used both in the past year (Odds Ratio = 1.42, 95% Confidence Interval: 1.14, 1.77). Both petroleum oil and diazinon showed consistent evidence of an association with rhinitis, based on both current use and exposure-response models. We saw no evidence of confounding by common agricultural rhinitis triggers such as handling grain or hay. Conclusions Exposure to pesticides may increase the risk of rhinitis. PMID:19289390

  9. Development of CMOS Active Pixel Image Sensors for Low Cost Commercial Applications

    NASA Technical Reports Server (NTRS)

    Gee, R.; Kemeny, S.; Kim, Q.; Mendis, S.; Nakamura, J.; Nixon, R.; Ortiz, M.; Pain, B.; Staller, C.; Zhou, Z; hide

    1994-01-01

    JPL, under sponsorship from the NASA Office of Advanced Concepts and Technology, has been developing a second-generation solid-state image sensor technology. Charge-coupled devices (CCD) are a well-established first generation image sensor technology. For both commercial and NASA applications, CCDs have numerous shortcomings. In response, the active pixel sensor (APS) technology has been under research. The major advantages of APS technology are the ability to integrate on-chip timing, control, signal-processing and analog-to-digital converter functions, reduced sensitivity to radiation effects, low power operation, and random access readout.

  10. 7 CFR 97.6 - Application for certificate.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... applicant shall submit with the application: (1) A declaration that at least 3,000 seeds of the viable basic... tuber propagated variety, a declaration that a viable cell culture will be deposited in a public...

  11. 7 CFR 97.6 - Application for certificate.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... applicant shall submit with the application: (1) A declaration that at least 3,000 seeds of the viable basic... tuber propagated variety, a declaration that a viable cell culture will be deposited in a public...

  12. 7 CFR 97.6 - Application for certificate.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... applicant shall submit with the application: (1) A declaration that at least 3,000 seeds of the viable basic... tuber propagated variety, a declaration that a viable cell culture will be deposited in a public...

  13. 7 CFR 97.6 - Application for certificate.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... applicant shall submit with the application: (1) A declaration that at least 3,000 seeds of the viable basic... tuber propagated variety, a declaration that a viable cell culture will be deposited in a public...

  14. 7 CFR 97.6 - Application for certificate.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... applicant shall submit with the application: (1) A declaration that at least 3,000 seeds of the viable basic... tuber propagated variety, a declaration that a viable cell culture will be deposited in a public...

  15. AlliedSignal driver's viewer enhancement (DVE) for paramilitary and commercial applications

    NASA Astrophysics Data System (ADS)

    Emanuel, Michael; Caron, Hubert; Kovacevic, Branislav; Faina-Cherkaoui, Marcela; Wrobel, Leslie; Turcotte, Gilles

    1999-07-01

    AlliedSignal Driver's Viewer Enhancement (DVE) system is a thermal imager using a 320 X 240 uncooled microbolometer array. This high performance system was initially developed for military combat and tactical wheeled vehicles. It features a very small sensor head remotely mounted from the display, control and processing module. The sensor head has a modular design and is being adapted to various commercial applications such as truck and car-driving aid, using specifically designed low cost optics. Tradeoffs in the system design, system features and test results are discussed in this paper. A short video shows footage of the DVE system while driving at night.

  16. Safety Evaluation of Two Commercial Lithium-ion Batteries for Space Applications

    NASA Technical Reports Server (NTRS)

    Jeevarajan, Judith A.; Collins, Jacob; Cook, Joseph S.

    2004-01-01

    Lithium-ion batteries have been used for applications on the Shuttle and Station for the past six years. A majority of the li-ion batteries flown are Commercial-off-the-shelf (COTS) varieties. The COTS batteries and cells were tested under nominal and abusive conditions for performance and safety characterization. Within the past six months two batteries have been certified for flight and use on the Space Station. The first one is a Hand Spring PDA battery that had a single prismatic li-ion cell and the second is an Iridium satellite phone that had a two-cell pack with prismatic li-ion cells.

  17. On the way to commercializing plant cell culture platform for biopharmaceuticals: present status and prospect.

    PubMed

    Xu, Jianfeng; Zhang, Ningning

    2014-12-01

    Plant cell culture is emerging as an alternative bioproduction system for recombinant pharmaceuticals. Growing plant cells in vitro under controlled environmental conditions allows for precise control over cell growth and protein production, batch-to-batch product consistency and a production process aligned with current good manufacturing practices. With the recent US FDA approval and commercialization of the world's first plant cell-based recombinant pharmaceutical for human use, β-glucocerebrosidase for treatment of Gaucher's disease, a new era has come in which plant cell culture shows high potential to displace some established platform technologies in niche markets. This review updates the progress in plant cell culture processing technology, highlights recent commercial successes and discusses the challenges that must be overcome to make this platform commercially viable.

  18. A Rapid Method for Quantifying Viable Mycobacterium avium subsp. paratuberculosis in Cellular Infection Assays

    PubMed Central

    Pooley, Hannah B.; de Silva, Kumudika; Purdie, Auriol C.; Begg, Douglas J.; Whittington, Richard J.

    2016-01-01

    ABSTRACT Determining the viability of bacteria is a key outcome of in vitro cellular infection assays. Currently, this is done by culture, which is problematic for fastidious slow-growing bacteria such as Mycobacterium avium subsp. paratuberculosis, where it can take up to 4 months to confirm growth. This study aimed to identify an assay that can rapidly quantify the number of viable M. avium subsp. paratuberculosis cells in a cellular sample. Three commercially available bacterial viability assays along with a modified liquid culture method coupled with high-throughput quantitative PCR growth detection were assessed. Criteria for assessment included the ability of each assay to differentiate live and dead M. avium subsp. paratuberculosis organisms and their accuracy at low bacterial concentrations. Using the culture-based method, M. avium subsp. paratuberculosis growth was reliably detected and quantified within 2 weeks. There was a strong linear association between the 2-week growth rate and the initial inoculum concentration. The number of viable M. avium subsp. paratuberculosis cells in an unknown sample was quantified based on the growth rate, by using growth standards. In contrast, none of the commercially available viability assays were suitable for use with samples from in vitro cellular infection assays. IMPORTANCE Rapid quantification of the viability of Mycobacterium avium subsp. paratuberculosis in samples from in vitro cellular infection assays is important, as it allows these assays to be carried out on a large scale. In vitro cellular infection assays can function as a preliminary screening tool, for vaccine development or antimicrobial screening, and also to extend findings derived from experimental animal trials. Currently, by using culture, it takes up to 4 months to obtain quantifiable results regarding M. avium subsp. paratuberculosis viability after an in vitro infection assay; however, with the quantitative PCR and liquid culture method

  19. Solid-state Graft Copolymer Electrolytes for Lithium Battery Applications

    PubMed Central

    Hu, Qichao; Caputo, Antonio; Sadoway, Donald R.

    2013-01-01

    Battery safety has been a very important research area over the past decade. Commercially available lithium ion batteries employ low flash point (<80 °C), flammable, and volatile organic electrolytes. These organic based electrolyte systems are viable at ambient temperatures, but require a cooling system to ensure that temperatures do not exceed 80 °C. These cooling systems tend to increase battery costs and can malfunction which can lead to battery malfunction and explosions, thus endangering human life. Increases in petroleum prices lead to a huge demand for safe, electric hybrid vehicles that are more economically viable to operate as oil prices continue to rise. Existing organic based electrolytes used in lithium ion batteries are not applicable to high temperature automotive applications. A safer alternative to organic electrolytes is solid polymer electrolytes. This work will highlight the synthesis for a graft copolymer electrolyte (GCE) poly(oxyethylene) methacrylate (POEM) to a block with a lower glass transition temperature (Tg) poly(oxyethylene) acrylate (POEA). The conduction mechanism has been discussed and it has been demonstrated the relationship between polymer segmental motion and ionic conductivity indeed has a Vogel-Tammann-Fulcher (VTF) dependence. Batteries containing commercially available LP30 organic (LiPF6 in ethylene carbonate (EC):dimethyl carbonate (DMC) at a 1:1 ratio) and GCE were cycled at ambient temperature. It was found that at ambient temperature, the batteries containing GCE showed a greater overpotential when compared to LP30 electrolyte. However at temperatures greater than 60 °C, the GCE cell exhibited much lower overpotential due to fast polymer electrolyte conductivity and nearly the full theoretical specific capacity of 170 mAh/g was accessed. PMID:23963203

  20. Solid-state graft copolymer electrolytes for lithium battery applications.

    PubMed

    Hu, Qichao; Caputo, Antonio; Sadoway, Donald R

    2013-08-12

    Battery safety has been a very important research area over the past decade. Commercially available lithium ion batteries employ low flash point (< 80 °C), flammable, and volatile organic electrolytes. These organic based electrolyte systems are viable at ambient temperatures, but require a cooling system to ensure that temperatures do not exceed 80 °C. These cooling systems tend to increase battery costs and can malfunction which can lead to battery malfunction and explosions, thus endangering human life. Increases in petroleum prices lead to a huge demand for safe, electric hybrid vehicles that are more economically viable to operate as oil prices continue to rise. Existing organic based electrolytes used in lithium ion batteries are not applicable to high temperature automotive applications. A safer alternative to organic electrolytes is solid polymer electrolytes. This work will highlight the synthesis for a graft copolymer electrolyte (GCE) poly(oxyethylene) methacrylate (POEM) to a block with a lower glass transition temperature (Tg) poly(oxyethylene) acrylate (POEA). The conduction mechanism has been discussed and it has been demonstrated the relationship between polymer segmental motion and ionic conductivity indeed has a Vogel-Tammann-Fulcher (VTF) dependence. Batteries containing commercially available LP30 organic (LiPF6 in ethylene carbonate (EC):dimethyl carbonate (DMC) at a 1:1 ratio) and GCE were cycled at ambient temperature. It was found that at ambient temperature, the batteries containing GCE showed a greater overpotential when compared to LP30 electrolyte. However at temperatures greater than 60 °C, the GCE cell exhibited much lower overpotential due to fast polymer electrolyte conductivity and nearly the full theoretical specific capacity of 170 mAh/g was accessed.

  1. Jumpstarting commercial-scale CO 2 capture and storage with ethylene production and enhanced oil recovery in the US Gulf

    DOE PAGES

    Middleton, Richard S.; Levine, Jonathan S.; Bielicki, Jeffrey M.; ...

    2015-04-27

    CO 2 capture, utilization, and storage (CCUS) technology has yet to be widely deployed at a commercial scale despite multiple high-profile demonstration projects. We suggest that developing a large-scale, visible, and financially viable CCUS network could potentially overcome many barriers to deployment and jumpstart commercial-scale CCUS. To date, substantial effort has focused on technology development to reduce the costs of CO 2 capture from coal-fired power plants. Here, we propose that near-term investment could focus on implementing CO 2 capture on facilities that produce high-value chemicals/products. These facilities can absorb the expected impact of the marginal increase in the costmore » of production on the price of their product, due to the addition of CO 2 capture, more than coal-fired power plants. A financially viable demonstration of a large-scale CCUS network requires offsetting the costs of CO 2 capture by using the CO 2 as an input to the production of market-viable products. As a result, we demonstrate this alternative development path with the example of an integrated CCUS system where CO 2 is captured from ethylene producers and used for enhanced oil recovery in the U.S. Gulf Coast region.« less

  2. Achieving AFRL Universal FADEC Vision With Open Architecture Addressing Capability and Obsolescence for Military and Commercial Applications (Preprint)

    DTIC Science & Technology

    2006-11-01

    engines will involve a family of common components. It will consist of a real - time operating system and partitioned application software (AS...system will employ a standard hardware and software architecture. It will consist of a real time operating system and partitioned application...Inputs - Enables Large Cost Reduction 3. Software - FAA Certified Auto Code - Real Time Operating System - Commercial

  3. Implications of previous space commercialization experiences for the reusable launch vehicle

    NASA Astrophysics Data System (ADS)

    Obermann, Richard M.; Williamson, Ray A.

    2003-07-01

    The United States' 1994 National Space Transportation Policy directed the National Aeronautics and Space Administration (NASA) to work with industry on the development of technologies required for a reusable launch vehicle (RLV). In the partnership that has evolved from that directive, NASA envisions its role as providing support for technological risk reduction and for developing space transportation to serve government needs. NASA officials assume that the development of an operational, commercial RLV will be carried out by the private sector without use of government funds. Under that scenario, the Federal government will simply become a customer for commercial RLV services. In evaluating the prospects for the development of a commercially viable RLV, it may be useful to examine "lessons learned" from previous space commercialization efforts—both those that succeeded and those that did not. It can be argued that several distinct streams of market and technological development may have to converge for successful commercialization of space systems to occur. Potential factors influencing the prospects for commercialization include the size and growth rate of the potential customer base, the extent to which a governmental customer exists to underpin the market, the development of associated "value-added" markets, the stability of governmental policies, the levels of technological and business risk, and the degree to which competitive markets exist. This paper examines two previous space commercialization experiences, evaluates the relative importance of the various factors that influence the prospects for success of commercialization efforts, and assesses the implications of those factors for the commercial viability of the proposed RLV.

  4. Intestinal stem cells remain viable after prolonged tissue storage

    PubMed Central

    Fuller, Megan K.; Faulk, Denver M.; Sundaram, Nambirajan; Mahe, Maxime M.; Stout, Kara M.; von Furstenberg, Richard J.; Smith, Brian J.; McNaughton, Kirk K.; Shroyer, Noah F.; Helmrath, Michael A.; Henning, Susan J.

    2013-01-01

    Intestinal stem cells (ISCs) are responsible for renewal of the epithelium both during normal homeostasis and following injury. As such they have significant therapeutic potential. However, it is unknown whether ISCs can survive tissue storage. We hypothesized that, although the majority of epithelial cells may die, ISCs would remain viable for at least 24 h at 4°C. To explore this hypothesis, jejuni of C57Bl6/J or Lgr5-LacZ mice were removed and either processed immediately or placed in phosphate buffered saline (PBS) at 4°C. Delayed isolations of epithelia were performed after 24, 30, or 48 h storage. At the light microscope level, despite extensive apoptosis of villus epithelial cells, small intestinal crypts remained morphologically intact through 30 h and ISCs were identifiable via Lgr5-LacZ positivity. Electron microscopy showed that ISCs retain high integrity through 24 h. When assessed by flow cytometry, ISCs were more resistant to degeneration than the rest of the epithelium, including neighboring Paneth cells, with higher viability across all time points. Culture of isolated crypts showed no loss of capacity to form complex enteroids after 24 h tissue storage, with efficiencies after 7 days of culture remaining above 80%. By 30 h storage, efficiencies declined but budding capability was retained. We conclude that, with delay in isolation, ISCs remain viable and retain their proliferative capacity. In contrast, the remainder of the epithelium, including the Paneth cells, exhibits degeneration and programmed cell death. If these findings are recapitulated with human tissue, storage at 4°C may offer a valuable temporal window for harvest of crypts or ISCs for therapeutic application. PMID:23820734

  5. Investigation of Removal Capacities of Biofilters for Airborne Viable Micro-Organisms

    PubMed Central

    Soret, Rémi; Fanlo, Jean-Louis; Malhautier, Luc; Geiger, Philippe; Bayle, Sandrine

    2018-01-01

    New emerging issues appears regarding the possible aerosolization of micro-organisms from biofilters to the ambient air. Traditional bioaerosol sampling and cultural methods used in literature offer relative efficiencies. In this study, a new method revolving around a particle counter capable of detecting total and viable particles in real time was used. This counter (BioTrak 9510-BD) uses laser-induced fluorescence (LIF) technology to determine the biological nature of the particle. The concentration of viable particles was measured on two semi-industrial pilot scale biofilters in order to estimate the Removal Efficiency in viable particles (REvp) in stable conditions and to examine the influence of pollutant feeding and relative humidification of the gaseous effluent on the REvp. The REvp of biofilters reached near 80% and highlighted both the stability of that removal and the statistical equivalence between two identical biofilters. Pollutant deprivation periods of 12 h, 48 h and 30 days were shown to have no influence on the biofilters’ removal capacity, demonstrating the robustness and adaptation capacities of the flora. In contrast, a 90-day famine period turned the biofilters into emitters of viable particles. Finally, the humidification of the effluent was shown to negatively influence the removal capacity for viable particles, as drying off the air was shown to increase the REvp from 60 to 85%. PMID:29562709

  6. Personalized skincare: from molecular basis to clinical and commercial applications.

    PubMed

    Markiewicz, Ewa; Idowu, Olusola Clement

    2018-01-01

    Individual responses of human skin to the environmental stress are determined by differences in the anatomy and physiology that are closely linked to the genetic characteristics such as pigmentation. Ethnic skin phenotypes can be distinguished based on defined genotypic traits, structural organization and compartmentalized sensitivity to distinct extrinsic aging factors. These differences are not only responsible for the variation in skin performance after exposure to damaging conditions, but can also affect the mechanisms of drug absorption, sensitization and other longer term effects. The unique characteristics of the individual skin function and, particularly, of the ethnic skin type are currently considered to shape the future of clinical and pharmacologic interventions as a basis for personalized skincare. Individual approaches to skincare render a novel and actively growing area with a range of biomedical and commercial applications within cosmetics industry. In this review, we summarize the aspects of the molecular and clinical manifestations of the environmental stress on human skin and proposed protective mechanisms that are linked to ethnic differences and pathophysiology of extrinsic skin aging. We subsequently discuss the possible applications and translation of this knowledge into personalized skincare.

  7. Personalized skincare: from molecular basis to clinical and commercial applications

    PubMed Central

    Markiewicz, Ewa; Idowu, Olusola Clement

    2018-01-01

    Individual responses of human skin to the environmental stress are determined by differences in the anatomy and physiology that are closely linked to the genetic characteristics such as pigmentation. Ethnic skin phenotypes can be distinguished based on defined genotypic traits, structural organization and compartmentalized sensitivity to distinct extrinsic aging factors. These differences are not only responsible for the variation in skin performance after exposure to damaging conditions, but can also affect the mechanisms of drug absorption, sensitization and other longer term effects. The unique characteristics of the individual skin function and, particularly, of the ethnic skin type are currently considered to shape the future of clinical and pharmacologic interventions as a basis for personalized skincare. Individual approaches to skincare render a novel and actively growing area with a range of biomedical and commercial applications within cosmetics industry. In this review, we summarize the aspects of the molecular and clinical manifestations of the environmental stress on human skin and proposed protective mechanisms that are linked to ethnic differences and pathophysiology of extrinsic skin aging. We subsequently discuss the possible applications and translation of this knowledge into personalized skincare. PMID:29692619

  8. Process heat in California: Applications and potential for solar energy in the industrial, agricultural and commercial sectors

    NASA Technical Reports Server (NTRS)

    Barbieri, R. H.; Bartera, R. E.; Davis, E. S.; Hlavka, G. E.; Pivirotto, D. S.; Yanow, G.

    1978-01-01

    A summary of the results of a survey of potential applications of solar energy for supplying process heat requirements in the industrial, agricultural, and commercial sectors of California is presented. Technical, economic, and institutional characteristics of the three sectors are examined. Specific applications for solar energy are then discussed. Finally, implications for California energy policy are discussed along with recommendations for possible actions by the State of California.

  9. Commercial and industrial applications of color ink jet: a technological perspective

    NASA Astrophysics Data System (ADS)

    Dunand, Alain

    1996-03-01

    In just 5 years, color ink-jet has become the dominant technology for printing color images and graphics in the office and home markets. In commercial printing, the traditional printing processes are being influenced by new digital techniques. Color ink-jet proofing, and concepts such as computer to film/plate or digital processes are contributing to the evolution of the industry. In industrial color printing, the penetration of digital techniques is just beginning. All widely used conventional contact printing technologies involve mechanical printing forms including plates, screens or engraved cylinders. Such forms, which need to be newly created and set up for each job, increase costs. In our era of fast changing customer demands, growing needs for customization, and increasing use of digital exchange of information, the commercial and industrial printing markets represent an enormous potential for digital printing technologies. The adoption characteristics for the use of color ink-jet in these industries are discussed. Examples of color ink-jet applications in the fields of billboard printing, floor/wall covering decoration, and textile printing are described. The requirements on print quality, productivity, reliability, substrate compatibility, and color lead to the consideration of various types of ink-jet technologies. Key technical enabling factors and directions for future improvements are presented.

  10. Natural transfer of viable microbes in space

    NASA Technical Reports Server (NTRS)

    Mileikowsky, C.; Cucinotta, F. A.; Wilson, J. W.; Gladman, B.; Horneck, G.; Lindegren, L.; Melosh, J.; Rickman, H.; Valtonen, M.; Zheng, J. Q.

    2000-01-01

    The possibility and probability of natural transfer of viable microbes from Mars to Earth and Earth to Mars traveling in meteoroids during the first 0.5 Ga and the following 4 Ga are investigated, including: --radiation protection against the galactic cosmic ray nuclei and the solar rays, dose rates as a function of the meteorite's radial column mass (radius x density), combined with dose rates generated by natural radioactivity within the meteorite; and survival curves for some bacterial species using NASA's HZETRN transport code --other factors affecting microbe survival: vacuum; central meteorite temperatures at launch, orbiting, and arrival; pressure and acceleration at launch; spontaneous DNA decay; metal ion migration --mean sizes and numbers of unshocked meteorites ejected and percentage falling on Earth, using current semiempirical results --viable flight times for the microbe species Bacillus subtilis and Deinococcus radiodurans R1 --the approximate fraction of microbes (with properties like the two species studied) viably arriving on Earth out of those ejected from Mars during the period 4 Ga BP to the present time, and during the 700 Ma from 4.5 to 3.8 Ga. Similarly, from Earth to Mars. The conclusion is that if microbes existed or exist on Mars, viable transfer to Earth is not only possible but also highly probable, due to microbes' impressive resistance to the dangers of space transfer and to the dense traffic of billions of martian meteorites which have fallen on Earth since the dawn of our planetary system. Earth-to-Mars transfer is also possible but at a much lower frequency.

  11. Natural transfer of viable microbes in space.

    PubMed

    Mileikowsky, C; Cucinotta, F A; Wilson, J W; Gladman, B; Horneck, G; Lindegren, L; Melosh, J; Rickman, H; Valtonen, M; Zheng, J Q

    2000-06-01

    The possibility and probability of natural transfer of viable microbes from Mars to Earth and Earth to Mars traveling in meteoroids during the first 0.5 Ga and the following 4 Ga are investigated, including: --radiation protection against the galactic cosmic ray nuclei and the solar rays, dose rates as a function of the meteorite's radial column mass (radius x density), combined with dose rates generated by natural radioactivity within the meteorite; and survival curves for some bacterial species using NASA's HZETRN transport code --other factors affecting microbe survival: vacuum; central meteorite temperatures at launch, orbiting, and arrival; pressure and acceleration at launch; spontaneous DNA decay; metal ion migration --mean sizes and numbers of unshocked meteorites ejected and percentage falling on Earth, using current semiempirical results --viable flight times for the microbe species Bacillus subtilis and Deinococcus radiodurans R1 --the approximate fraction of microbes (with properties like the two species studied) viably arriving on Earth out of those ejected from Mars during the period 4 Ga BP to the present time, and during the 700 Ma from 4.5 to 3.8 Ga. Similarly, from Earth to Mars. The conclusion is that if microbes existed or exist on Mars, viable transfer to Earth is not only possible but also highly probable, due to microbes' impressive resistance to the dangers of space transfer and to the dense traffic of billions of martian meteorites which have fallen on Earth since the dawn of our planetary system. Earth-to-Mars transfer is also possible but at a much lower frequency.

  12. Smartphone-based rapid quantification of viable bacteria by single-cell microdroplet turbidity imaging.

    PubMed

    Cui, Xiaonan; Ren, Lihui; Shan, Yufei; Wang, Xixian; Yang, Zhenlong; Li, Chunyu; Xu, Jian; Ma, Bo

    2018-05-18

    Standard plate count (SPC) has been recognized as the golden standard for the quantification of viable bacteria. However, SPC usually takes one to several days to grow individual cells into a visible colony, which greatly hampers its application in rapid bacteria enumeration. Here we present a microdroplet turbidity imaging based digital standard plate count (dSPC) method to overcome this hurdle. Instead of cultivating on agar plates, bacteria are encapsulated in monodisperse microdroplets for single-cell cultivation. Proliferation of the encapsulated bacterial cell produced a detectable change in microdroplet turbidity, which allowed, after just a few bacterial doubling cycles (i.e., a few hours), enumeration of viable bacteria by visible-light imaging. Furthermore, a dSPC platform integrating a power-free droplet generator with smartphone-based turbidity imaging was established. As proof-of-concept demonstrations, a series of Gram-negative bacteria (Escherichia coli) and Gram-positive bacteria (Bacillus subtilis) samples were quantified via the smartphone dSPC accurately within 6 hours, representing a detection sensitivity of 100 CFU ml-1 and at least 3 times faster. In addition, Enterobacter sakazakii (E. sakazakii) in infant milk powder as a real sample was enumerated within 6 hours, in contrast to the 24 hours needed in traditional SPC. Results with high accuracy and reproducibility were achieved, with no difference in counts found between dSPC and SPC. By enabling label-free, rapid, portable and low-cost enumeration and cultivation of viable bacteria onsite, smartphone dSPC forms the basis for a temporally and geographically trackable network for surveying live microbes globally where every citizen with a cellphone can contribute anytime and anywhere.

  13. Intersatellite Link (ISL) application to commercial communications satellites. Volume 1: Executive summary

    NASA Technical Reports Server (NTRS)

    Young, S. Lee

    1987-01-01

    Based on a comprehensive evaluation of the fundamental Intersatellite Link (ISL) systems characteristics, potential applications of ISLs to domestic, regional, and global commercial satellite communications were identified, and their cost-effectiveness and other systems benefits quantified wherever possible. Implementation scenarios for the cost-effective communications satellite systems employing ISLs were developed for the first launch in 1993 to 1994 and widespread use of ISLs in the early 2000's. Critical technology requirements for both the microwave (60 GHz) and optical (0.85 micron) ISL implementations were identified, and their technology development programs, including schedule and cost estimates, were derived.

  14. Thermal characterization of three-dimensional printed components for light-emitting diode lighting system applications

    NASA Astrophysics Data System (ADS)

    Perera, Indika U.; Narendran, Nadarajah; Terentyeva, Valeria

    2018-04-01

    This study investigated the thermal properties of three-dimensional (3-D) printed components with the potential to be used for thermal management in light-emitting diode (LED) applications. Commercially available filament materials with and without a metal filler were characterized with changes to the print orientation. 3-D printed components with an in-plane orientation had >30 % better effective thermal conductivity compared with components printed with a cross-plane orientation. A finite-element analysis was modeled to understand the effective thermal conductivity changes in the 3-D printed components. A simple thermal resistance model was used to estimate the required effective thermal conductivity of the 3-D printed components to be a viable alternative in LED thermal management applications.

  15. The NASA LeRC regenerative fuel cell system testbed program for goverment and commercial applications

    NASA Astrophysics Data System (ADS)

    Maloney, Thomas M.; Prokopius, Paul R.; Voecks, Gerald E.

    1995-01-01

    The Electrochemical Technology Branch of the NASA Lewis Research Center (LeRC) has initiated a program to develop a renewable energy system testbed to evaluate, characterize, and demonstrate fully integrated regenerative fuel cell (RFC) system for space, military, and commercial applications. A multi-agency management team, led by NASA LeRC, is implementing the program through a unique international coalition which encompasses both government and industry participants. This open-ended teaming strategy optimizes the development for space, military, and commercial RFC system technologies. Program activities to date include system design and analysis, and reactant storage sub-system design, with a major emphasis centered upon testbed fabrication and installation and testing of two key RFC system components, namely, the fuel cells and electrolyzers. Construction of the LeRC 25 kW RFC system testbed at the NASA-Jet Propulsion Labortory (JPL) facility at Edwards Air Force Base (EAFB) is nearly complete and some sub-system components have already been installed. Furthermore, planning for the first commercial RFC system demonstration is underway.

  16. Spatiotemporal Dynamics of Total Viable Vibrio spp. in a NW Mediterranean Coastal Area.

    PubMed

    Girard, Léa; Peuchet, Sébastien; Servais, Pierre; Henry, Annabelle; Charni-Ben-Tabassi, Nadine; Baudart, Julia

    2017-09-27

    A cellular approach combining Direct Viable Counting and Fluorescent In Situ Hybridization using a one-step multiple-probe technique and Solid Phase Cytometry (DVC-FISH-SPC) was developed to monitor total viable vibrios and cover the detection of a large diversity of vibrios. FISH combined three probes in the same assay and targeted sequences located at different positions on the 16S rRNA of Vibrio and Aliivibrio members. We performed a 10-month in situ study to investigate the weekly dynamics of viable vibrios relative to culturable counts at two northwestern Mediterranean coastal sites, and identified the key physicochemical factors for their occurrence in water using a multivariate analysis. Total viable and culturable cell counts showed the same temporal pattern during the warmer season, whereas the ratios between both methods were inverted during the colder seasons (<15°C), indicating that some of the vibrio community had entered into a viable but non-culturable (VBNC) state. We confirmed that Seawater Surface Temperature explained 51-62% of the total variance in culturable counts, and also showed that the occurrence of viable vibrios is controlled by two variables, pheopigment (15%) and phosphate (12%) concentrations, suggesting that other unidentified factors play a role in maintaining viability.

  17. On the way to commercializing plant cell culture platform for biopharmaceuticals: present status and prospect

    PubMed Central

    Xu, Jianfeng; Zhang, Ningning

    2014-01-01

    Plant cell culture is emerging as an alternative bioproduction system for recombinant pharmaceuticals. Growing plant cells in vitro under controlled environmental conditions allows for precise control over cell growth and protein production, batch-to-batch product consistency and a production process aligned with current good manufacturing practices. With the recent US FDA approval and commercialization of the world’s first plant cell-based recombinant pharmaceutical for human use, β-glucocerebrosidase for treatment of Gaucher’s disease, a new era has come in which plant cell culture shows high potential to displace some established platform technologies in niche markets. This review updates the progress in plant cell culture processing technology, highlights recent commercial successes and discusses the challenges that must be overcome to make this platform commercially viable. PMID:25621170

  18. 9 CFR 113.26 - Detection of viable bacteria and fungi except in live vaccine.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 9 Animals and Animal Products 1 2011-01-01 2011-01-01 false Detection of viable bacteria and fungi... VECTORS STANDARD REQUIREMENTS Standard Procedures § 113.26 Detection of viable bacteria and fungi except... required to be free of viable bacteria and fungi, they shall also be tested as prescribed in this section...

  19. 9 CFR 113.26 - Detection of viable bacteria and fungi except in live vaccine.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 9 Animals and Animal Products 1 2010-01-01 2010-01-01 false Detection of viable bacteria and fungi... VECTORS STANDARD REQUIREMENTS Standard Procedures § 113.26 Detection of viable bacteria and fungi except... required to be free of viable bacteria and fungi, they shall also be tested as prescribed in this section...

  20. Monotone viable trajectories for functional differential inclusions

    NASA Astrophysics Data System (ADS)

    Haddad, Georges

    This paper is a study on functional differential inclusions with memory which represent the multivalued version of retarded functional differential equations. The main result gives a necessary and sufficient equations. The main result gives a necessary and sufficient condition ensuring the existence of viable trajectories; that means trajectories remaining in a given nonempty closed convex set defined by given constraints the system must satisfy to be viable. Some motivations for this paper can be found in control theory where F( t, φ) = { f( t, φ, u)} uɛU is the set of possible velocities of the system at time t, depending on the past history represented by the function φ and on a control u ranging over a set U of controls. Other motivations can be found in planning procedures in microeconomics and in biological evolutions where problems with memory do effectively appear in a multivalued version. All these models require viability constraints represented by a closed convex set.

  1. Viable adhered Staphylococcus aureus highly reduced on novel antimicrobial sutures using chlorhexidine and octenidine to avoid surgical site infection (SSI).

    PubMed

    Obermeier, Andreas; Schneider, Jochen; Harrasser, Norbert; Tübel, Jutta; Mühlhofer, Heinrich; Pförringer, Dominik; Deimling, Constantin von; Foehr, Peter; Kiefel, Barbara; Krämer, Christina; Stemberger, Axel; Schieker, Matthias; Burgkart, Rainer; von Eisenhart-Rothe, Rüdiger

    2018-01-01

    Surgical sutures can promote migration of bacteria and thus start infections. Antiseptic coating of sutures may inhibit proliferation of adhered bacteria and avoid such complications. This study investigated the inhibition of viable adhering bacteria on novel antimicrobially coated surgical sutures using chlorhexidine or octenidine, a critical factor for proliferation at the onset of local infections. The medical need, a rapid eradication of bacteria in wounds, can be fulfilled by a high antimicrobial efficacy during the first days after wound closure. As a pretesting on antibacterial efficacy against relevant bacterial pathogens a zone of inhibition assay was conducted with middle ranged concentrated suture coatings (22 μg/cm). For further investigation of adhering bacteria in detail the most clinically relevant Staphylococcus aureus (ATCC®49230™) was used. Absorbable braided sutures were coated with chlorhexidine-laurate, chlorhexidine-palmitate, octenidine-laurate, and octenidine-palmitate. Each coating type resulted in 11, 22, or 33 μg/cm drug content on sutures. Scanning electron microscopy (SEM) was performed once to inspect the coating quality and twice to investigate if bacteria have colonized on sutures. Adhesion experiments were assessed by exposing coated sutures to S. aureus suspensions for 3 h at 37°C. Subsequently, sutures were sonicated and the number of viable bacteria released from the suture surface was determined. Furthermore, the number of viable planktonic bacteria was measured in suspensions containing antimicrobial sutures. Commercially available sutures without drugs (Vicryl®, PGA Resorba®, and Gunze PGA), as well as triclosan-containing Vicryl® Plus were used as control groups. Zone of inhibition assay documented a multispecies efficacy of novel coated sutures against tested bacterial strains, comparable to most relevant S. aureus over 48 hours. SEM pictures demonstrated uniform layers on coated sutures with higher roughness for

  2. 75 FR 14609 - Commercial Fishing Industry Vessel Safety Advisory Committee; Vacancies

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-03-26

    ... DEPARTMENT OF HOMELAND SECURITY Coast Guard [Docket No. USCG-2010-0163] Commercial Fishing... applications. SUMMARY: The Coast Guard seeks applications for membership on the Commercial Fishing Industry... Coast Guard on matters relating to the safe operation of commercial fishing industry vessels. DATES...

  3. Small-wind-systems application analysis. Technical report and executive summary

    NASA Astrophysics Data System (ADS)

    1981-06-01

    A small wind energy conversion systems (SWECS) analysis was conducted to estimate the potential market for SWEC, or wind machines smaller than 100 kW for five selected applications. The goals were to aid manufacturers in attaining financing by convincing venture capital investors of the potential of SWECS and to aid government planners in allocating R and D expenditures that will effectively advance SWECS commercialization. Based on these goals, the study: (1) provides a basis for assisting the DOE in planning R and D programs that will advance the state of SWECS industry; (2) quantifies estimates of market size vs. installed system cost to enable industry to plan expansion of capacity and product lines; (3) identifies marketing strategies for industry to use in attaining financing from investors and in achieving sales goals; and (4) provides DOE with data that will assist in determining actions, incentives, and/or legislation required to achieve a commercially viable SWECS industry. The five applications were selected through an initial screening and priority-ranking analysis. The year of analysis was 1985, but all dollar amounts, such as fuel costs, are expressed in 1980 dollars. The five SWECS applications investigated were farm residences, non-farm residences, rural electric cooperatives, feed grinders, and remote communities.

  4. 47 CFR 73.4075 - Commercials, loud.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 47 Telecommunication 4 2010-10-01 2010-10-01 false Commercials, loud. 73.4075 Section 73.4075 Telecommunication FEDERAL COMMUNICATIONS COMMISSION (CONTINUED) BROADCAST RADIO SERVICES RADIO BROADCAST SERVICES Rules Applicable to All Broadcast Stations § 73.4075 Commercials, loud. See Memorandum Opinion and Order...

  5. 47 CFR 73.4075 - Commercials, loud.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 47 Telecommunication 4 2011-10-01 2011-10-01 false Commercials, loud. 73.4075 Section 73.4075 Telecommunication FEDERAL COMMUNICATIONS COMMISSION (CONTINUED) BROADCAST RADIO SERVICES RADIO BROADCAST SERVICES Rules Applicable to All Broadcast Stations § 73.4075 Commercials, loud. See Memorandum Opinion and Order...

  6. Can surveillance systems identify and avert adverse drug events? A prospective evaluation of a commercial application.

    PubMed

    Jha, Ashish K; Laguette, Julia; Seger, Andrew; Bates, David W

    2008-01-01

    Computerized monitors can effectively detect and potentially prevent adverse drug events (ADEs). Most monitors have been developed in large academic hospitals and are not readily usable in other settings. We assessed the ability of a commercial program to identify and prevent ADEs in a community hospital. and Measurement We prospectively evaluated the commercial application in a community-based hospital. We examined the frequency and types of alerts produced, how often they were associated with ADEs and potential ADEs, and the potential financial impact of monitoring for ADEs. Among 2,407 patients screened, the application generated 516 high priority alerts. We were able to review 266 alerts at the time they were generated and among these, 30 (11.3%) were considered substantially important to warrant contacting the physician caring for the patient. These 30 alerts were associated with 4 ADEs and 11 potential ADEs. In all 15 cases, the responsible physician was unaware of the event, leading to a change in clinical care in 14 cases. Overall, 23% of high priority alerts were associated with an ADE (95% confidence interval [CI] 12% to 34%) and another 15% were associated with a potential ADE (95% CI 6% to 24%). Active surveillance used approximately 1.5 hours of pharmacist time daily. A commercially available, computer-based ADE detection tool was effective at identifying ADEs. When used as part of an active surveillance program, it can have an impact on preventing or ameliorating ADEs.

  7. Optimization, validation, and application of a real-time PCR protocol for quantification of viable bacterial cells in municipal sewage sludge and biosolids using reporter genes and Escherichia coli.

    PubMed

    van Frankenhuyzen, Jessica K; Trevors, Jack T; Flemming, Cecily A; Lee, Hung; Habash, Marc B

    2013-11-01

    Biosolids result from treatment of sewage sludge to meet jurisdictional standards, including pathogen reduction. Once government regulations are met, materials can be applied to agricultural lands. Culture-based methods are used to enumerate pathogen indicator microorganisms but may underestimate cell densities, which is partly due to bacteria existing in a viable but non-culturable physiological state. Viable indicators can also be quantified by realtime polymerase chain reaction (qPCR) used with propidium monoazide (PMA), a dye that inhibits amplification of DNA found extracellularly or in dead cells. The objectives of this study were to test an optimized PMA-qPCR method for viable pathogen detection in wastewater solids and to validate it by comparing results to data obtained by conventional plating. Reporter genes from genetically marked Pseudomonas sp. UG14Lr and Agrobacterium tumefaciens 542 cells were spiked into samples of primary sludge, and anaerobically digested and Lystek-treated biosolids as cell-free DNA, dead cells, viable cells, and mixtures of live and dead cells, followed by DNA extraction with and without PMA, and qPCR. The protocol was then used for Escherichia coli quantification in the three matrices, and results compared to plate counts. PMA-qPCR selectively detected viable cells, while inhibiting signals from cell-free DNA and DNA found in membrane-compromised cells. PMA-qPCR detected 0.5-1 log unit more viable E. coli cells in both primary solids and dewatered biosolids than plate counts. No viable E. coli was found in Lystek-treated biosolids. These data suggest PMA-qPCR may more accurately estimate pathogen cell numbers than traditional culture methods.

  8. Commercialization of biomass projects: A case study of the design, development, and application of a biomass gasifier to a large retrofit market

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Woerner, W.L.

    1994-12-31

    The steam production potential of older biomass-fired boilers currently in operation may be significantly increased through the application of a commercially available gasifier. A large percentage of boiler systems in lumber mills and similar applications were initially designed to generate steam through convection heat transfer, and have been horse power rated at approximately 7 to 10 square feet of heating surface to the horse power. This paper deals with the before and after performance characteristics of the first gasifier retrofit installation based on an AED designed unit currently commercially available.

  9. Using Generic Examples to Make Viable Arguments

    ERIC Educational Resources Information Center

    Adams, Anne E.; Ely, Rob; Yopp, David

    2017-01-01

    The twenty-first century has seen an increased call to train students to craft mathematical arguments. The third of the Common Core's (CCSS) Standards for Mathematical Practice (SMP 3) (CCSSI 2010) calls for all mathematically proficient students to "construct viable arguments" to support the truth of their ideas and to "critique…

  10. Architecture Studies for Commercial Production of Propellants From the Lunar Poles

    NASA Astrophysics Data System (ADS)

    Duke, Michael B.; Diaz, Javier; Blair, Brad R.; Oderman, Mark; Vaucher, Marc

    2003-01-01

    Two architectures are developed that could be used to convert water held in regolith deposits within permanently shadowed lunar craters into propellant for use in near-Earth space. In particular, the model has been applied to an analysis of the commercial feasibility of using lunar derived propellant to convey payloads from low Earth orbit to geosynchronous Earth orbit. Production and transportation system masses were estimated for each architecture and cost analysis was made using the NAFCOM cost model. Data from the cost model were analyzed using a financial analysis tool reported in a companion paper (Lamassoure et al., 2002) to determine under what conditions the architectures might be commercially viable. Analysis of the architectural assumptions is used to identify the principal areas for further research, which include technological development of lunar mining and water extraction systems, power systems, reusable space transportation systems, and orbital propellant depots. The architectures and commercial viability are sensitive to the assumed concentration of ice in the lunar deposits, suggesting that further lunar exploration to determine whether higher-grade deposits exist would be economically justified.

  11. Merit pay: viable?

    PubMed

    Farmer, C R

    1978-01-01

    Can an organization really have a meaningful relationship between its merit pay program and motivation of its employees? C. Richard Farmer of Armstrong Cork says yes--if. If the approach to granting merit pay increases is coupled with a salary structure attuned to economic and competitive conditions, and if it is communicated effectively and openly to the employees, then it automatically translates labor market activity, performance, and the cost of living into a meaningful increase. Position descriptions, evaluations, and performance appraisals are some of the tools essential to a viable merit pay program. But besides these definite do's, the author outlines some of the don'ts of merit pay programs, such as centralized administration of the program--policies, programs, and procedures may be centralized, but their administration must be carried out by those close to the individual employees and work units. Above all, the merit pay program must be based on performance, not longevity.

  12. Regulatory guidance concerning the applicability of the Federal Motor Carrier Safety regulations to texting by commercial motor vehicle drivers

    DOT National Transportation Integrated Search

    2010-01-10

    The FMCSA announces regulatory guidance concerning texting while driving a commercial motor vehicle (CMV). The guidance is applicable to all interstate drivers of CMVs subject to the Federal Motor Carrier Safety Regulations (FMCSRs).

  13. Commercial speech in crisis: Crisis Pregnancy Center regulations and definitions of commercial speech.

    PubMed

    Gilbert, Kathryn E

    2013-02-01

    Recent attempts to regulate Crisis Pregnancy Centers, pseudoclinics that surreptitiously aim to dissuade pregnant women from choosing abortion, have confronted the thorny problem of how to define commercial speech. The Supreme Court has offered three potential answers to this definitional quandary. This Note uses the Crisis Pregnancy Center cases to demonstrate that courts should use one of these solutions, the factor-based approach of Bolger v. Youngs Drugs Products Corp., to define commercial speech in the Crisis Pregnancy Center cases and elsewhere. In principle and in application, the Bolger factor-based approach succeeds in structuring commercial speech analysis at the margins of the doctrine.

  14. Airborne viable fungi in school environments in different climatic regions - A review

    NASA Astrophysics Data System (ADS)

    Salonen, Heidi; Duchaine, Caroline; Mazaheri, Mandana; Clifford, Sam; Lappalainen, Sanna; Reijula, Kari; Morawska, Lidia

    2015-03-01

    Elevated levels of fungi in indoor environments have been linked with mould/moisture damage in building structures. However, there is a lack of information about "normal" concentrations and flora as well as guidelines of viable fungi in the school environment in different climatic conditions. We have reviewed existing guidelines for indoor fungi and the current knowledge of the concentrations and flora of viable fungi in different climatic areas, the impact of the local factors on concentrations and flora of viable fungi in school environments. Meta-regression was performed to estimate the average behaviour for each analysis of interest, showing wide variation in the mean concentrations in outdoor and indoor school environments (range: 101-103 cfu/m3). These concentrations were significantly higher for both outdoors and indoors in the moderate than in the continental climatic area, showing that the climatic condition was a determinant for the concentrations of airborne viable fungi. The most common fungal species both in the moderate and continental area were Cladosporium spp. and Penicillium spp. The suggested few quantitative guidelines for indoor air viable fungi for school buildings are much lower than for residential areas. This review provides a synthesis, which can be used to guide the interpretation of the fungi measurements results and help to find indications of mould/moisture in school building structures.

  15. The NASA LeRC regenerative fuel cell system testbed program for goverment and commercial applications

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Maloney, T.M.; Prokopius, P.R.; Voecks, G.E.

    1995-01-25

    The Electrochemical Technology Branch of the NASA Lewis Research Center (LeRC) has initiated a program to develop a renewable energy system testbed to evaluate, characterize, and demonstrate fully integrated regenerative fuel cell (RFC) system for space, military, and commercial applications. A multi-agency management team, led by NASA LeRC, is implementing the program through a unique international coalition which encompasses both government and industry participants. This open-ended teaming strategy optimizes the development for space, military, and commercial RFC system technologies. Program activities to date include system design and analysis, and reactant storage sub-system design, with a major emphasis centered upon testbedmore » fabrication and installation and testing of two key RFC system components, namely, the fuel cells and electrolyzers. Construction of the LeRC 25 kW RFC system testbed at the NASA-Jet Propulsion Labortory (JPL) facility at Edwards Air Force Base (EAFB) is nearly complete and some sub-system components have already been installed. Furthermore, planning for the first commercial RFC system demonstration is underway. {copyright} {ital 1995} {ital American} {ital Institute} {ital of} {ital Physics}« less

  16. Native perennial forb tolerance to repeated annual applications of postemergence herbicides

    Treesearch

    Clinton C. Shock; Joey Ishida; Erik Feibert; Nancy Shaw

    2009-01-01

    Native forb seed is needed to restore rangelands of the Intermountain West. Commercial seed production is necessary to provide the quantity of seed needed for restoration efforts. A major limitation to economically viable commercial production of native forb seed is weed competition. Weeds are adapted to growing in disturbed soil, and native forbs are not competitive...

  17. L929 cell cytotoxicity associated with experimental and commercial dental flosses

    NASA Astrophysics Data System (ADS)

    Tua-ngam, P.; Supanitayanon, L.; Dechkunakorn, S.; Anuwongnukroh, N.; Srikhirin, T.; Roongrujimek, P.

    2017-11-01

    This aim of the study was to investigate the cytotoxicity of two commercial and two experimental dental flosses. Two commercial, Oral B® Essential Floss (nylon-waxed) and Thai Silk Floss (silk-waxed), and two experimental, Floss X (nylon-waxed) and Floss Xu (nylon-unwaxed) dental flosses were used. The cytotoxic assay was performed by using cell cultures (L929) which were subjected to cell viability test with methyl-tetrazolium. Each floss specimen (0.4 g) was placed in 1 ml of Minimum Essential Medium at 37°C with 5% CO2 at 100% humidity in an incubator for 24 hours. After incubation, the cell mitochondrial activity was evaluated for detecting viable cells using optical density as per the guidelines of ISO 10993-5:2009(E). Cytotoxic effects were evaluated by measuring percentage of cell viability at 3 points of time- 5 mins, 30 mins, and 1 hr. The results showed that two commercial dental flosses and Floss X had cell viability about 90% at the three time points; however, the experimental Floss Xu presented 80% cell viability at 5 min and <70% cell viability at 30 min and 1 hr. The results concluded that the commercial dental flosses and the experimental dental floss with wax tested in this study were acceptable for clinical use.

  18. Formation and resuscitation of viable but nonculturable Salmonella typhi.

    PubMed

    Zeng, Bin; Zhao, Guozhong; Cao, Xiaohong; Yang, Zhen; Wang, Chunling; Hou, Lihua

    2013-01-01

    Salmonella typhi is a pathogen that causes the human disease of typhoid fever. The aim of this study was to investigate the viable but nonculturable (VBNC) state of S. typhi. Some samples were stimulated at 4°C or -20°C, while others were induced by different concentrations of CuSO4. Total cell counts remained constant throughout several days by acridine orange direct counting; however, plate counts declined to undetectable levels within 48 hours by plate counting at -20°C. The direct viable counts remained fairly constant at this level by direct viable counting. Carbon and nitrogen materials slowly decreased which indicated that a large population of cells existed in the VBNC state and entered the VBNC state in response to exposure to 0.01 or 0.015 mmol/L CuSO4 for more than 14 or 12 days, respectively. Adding 3% Tween 20 or 1% catalase enabled cells to become culturable again, with resuscitation times of 48 h and 24 h, respectively. The atomic force microscope results showed that cells gradually changed in shape from short rods to coccoids, and decreased in size when they entered the VBNC state. Further animal experiments suggested that resuscitated cells might regain pathogenicity.

  19. Prospects for commercial production of diatoms

    DOE PAGES

    Wang, Jaw -Kai; Seibert, Michael

    2017-01-18

    In this paper, a simple procedure that portends the open-pond growth of commercially viable diatoms is discussed. We examined a number of topics relevant to the production and harvesting of diatoms as well as topics concerning the production of bioproducts from diatoms. Among the former topics, we show that it is currently possible to continuously grow diatoms and control the presence of invasive species without chemical toxins at an average annual yield of 132 MT dry diatoms ha -1 over a period of almost 5 years, while maintaining the dominancy of the optimal diatom species on a seasonal basis. Themore » dominant species varies during the year. The production of microalgae is essentially agriculture, but without the ability to control invasive species in the absence of herbicides and insecticides, pollution and production costs would be prohibitive. Among the latter topics are the discussions of whether it is better to produce lipids and then convert them to biofuels or maximize the production of diatom biomass and then convert it to biocrude products using, for example, hydrothermal processes. It is becoming increasingly evident that without massive public support, the commercial production of microalgal biofuels alone will remain elusive. While economically competitive production of biofuels from diatoms will be difficult, when priority is given to multiple high-value products, including wastewater treatment, and when biofuels are considered co-products in a systems approach to commercial production of diatoms, an economically competitive process will become more likely.« less

  20. Prospects for commercial production of diatoms

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Wang, Jaw -Kai; Seibert, Michael

    In this paper, a simple procedure that portends the open-pond growth of commercially viable diatoms is discussed. We examined a number of topics relevant to the production and harvesting of diatoms as well as topics concerning the production of bioproducts from diatoms. Among the former topics, we show that it is currently possible to continuously grow diatoms and control the presence of invasive species without chemical toxins at an average annual yield of 132 MT dry diatoms ha -1 over a period of almost 5 years, while maintaining the dominancy of the optimal diatom species on a seasonal basis. Themore » dominant species varies during the year. The production of microalgae is essentially agriculture, but without the ability to control invasive species in the absence of herbicides and insecticides, pollution and production costs would be prohibitive. Among the latter topics are the discussions of whether it is better to produce lipids and then convert them to biofuels or maximize the production of diatom biomass and then convert it to biocrude products using, for example, hydrothermal processes. It is becoming increasingly evident that without massive public support, the commercial production of microalgal biofuels alone will remain elusive. While economically competitive production of biofuels from diatoms will be difficult, when priority is given to multiple high-value products, including wastewater treatment, and when biofuels are considered co-products in a systems approach to commercial production of diatoms, an economically competitive process will become more likely.« less

  1. Commercialization of an S-band standing-wave electron accelerator for industrial applications

    NASA Astrophysics Data System (ADS)

    Moon, Jin-Hyeok; Kwak, Gyeong-Il; Han, Jae-Ik; Lee, Gyu-Baek; Jeon, Seong-Hwan; Kim, Jae-Young; Hwang, Cheol-Bin; Lee, Gi-Yong; Kim, Young-Man; Park, Sung-Ju

    2016-09-01

    An electron accelerator system has been developed for use in industrial, as well as possible medical, applications. Based on our experiences achieved during prototype system development and various electron beam acceleration tests, we have built a stable and compact system for sales purposes. We have integrated a self-developed accelerating cavity, an E-gun pulse driver, a radio-frequency (RF) power system, a vacuum system, a cooling system, etc. into a frame with a size of 1800 × 1000 × 1500 mm3. The accelerating structure is a side-coupled standing-wave type operating in the π/2 mode (tuned to~3 GHz). The RF power is provided by using a magnetron driven by a solid-state modulator. The electron gun is a triode type with a dispenser cathode (diameter of 11 mm). The system is capable of delivering a maximum 900-W average electron beam power with tight focusing at the target. Until now, we have performed various electron beam tests and X-ray beam tests after having built the system, have completed the beam assessment for commercializations, and have been preparing full-fledged sales activity. This article reports on our system development processes and on some of our early test results for commercializations.

  2. Development of a Topical Resveratrol Formulation for Commercial Applications Using Dendrimer Nanotechnology.

    PubMed

    Pentek, Tyler; Newenhouse, Eric; O'Brien, Brennin; Chauhan, Abhay Singh

    2017-01-14

    Resveratrol (RSV) is well known for its anti-oxidant and anti-aging properties. However, resveratrol is insoluble in water and has stability issues. Recently, efforts were placed to prepare a resveratrol-based advanced anti-aging topical product but it contains harsh organic solvents and oils that could be harmful to the human body and the environment. Hence, we propose the use of a multifunctional dendrimer to solve the solubility and stability issues of resveratrol. A dendrimer-resveratrol complex was prepared, optimized and tested for solubility enhancement, stability in solution and cream dosage forms. We have also developed a high performance liquid chromatography method to measure the resveratrol within the final product. PAMAM dendrimers increased the solubility and stability of resveratrol in water and semisolid dosage forms. Therefore, this product would be water based 'green' formulation devoid of harsh organic solvents and oils and can be safely applied to the skin. Additionally, we have shown that the dendrimer helped to increase overall RSV loading and skin penetration of resveratrol. The dendrimer-RSV formulation was successfully scaled up towards commercialization. Dendrimer with RSV has led to an innovation in anti-aging cream and solutions that could be commercially marketed. Dendrimer-RSV complex could also be added to other product forms for additional purposes and applications.

  3. A survey and analysis of commercially available hydrogen sensors

    NASA Technical Reports Server (NTRS)

    Hunter, Gary W.

    1992-01-01

    The performance requirements for hydrogen detection in aerospace applications often exceed those of more traditional applications. In order to ascertain the applicability of existing hydrogen sensors to aerospace applications, a survey was conducted of commercially available point-contact hydrogen sensors, and their operation was analyzed. The operation of the majority of commercial hydrogen sensors falls into four main categories: catalytic combustion, electrochemical, semiconducting oxide sensors, and thermal conductivity detectors. The physical mechanism involved in hydrogen detection for each main category is discussed in detail. From an understanding of the detection mechanism, each category of sensor is evaluated for use in a variety of space and propulsion environments. In order to meet the needs of aerospace applications, the development of point-contact hydrogen sensors that are based on concepts beyond those used in commercial sensors is necessary.

  4. Commercial use of remote sensing in agriculture: a case study

    NASA Astrophysics Data System (ADS)

    Gnauck, Gary E.

    1999-12-01

    Over 25 years of research have clearly shown that an analysis of remote sensing imagery can provide information on agricultural crops. Most of this research has been funded by and directed toward the needs of government agencies. Commercial use of agricultural remote sensing has been limited to very small-scale operations supplying remote sensing services to a few selected customers. Datron/Transco Inc. undertook an internally funded remote sensing program directed toward the California cash crop industry (strawberries, lettuce, tomatoes, other fresh vegetables and cotton). The objectives of this program were twofold: (1) to assess the need and readiness of agricultural land managers to adopt remote sensing as a management tool, and (2) determine what technical barriers exist to large-scale implementation of this technology on a commercial basis. The program was divided into three phases: Planning, Engineering Test and Evaluation, and Commercial Operations. Findings: Remote sensing technology can deliver high resolution multispectral imagery with rapid turnaround, that can provide information on crop stress insects, disease and various soil parameters. The limiting factors to the use of remote sensing in agriculture are a lack of familiarization by the land managers, difficulty in translating 'information' into increased revenue or reduced cost for the land manager, and the large economies of scale needed to make the venture commercially viable.

  5. The Seasat commercial demonstration program

    NASA Technical Reports Server (NTRS)

    Mccandless, S. W.; Miller, B. P.; Montgomery, D. R.

    1981-01-01

    The background and development of the Seasat commercial demonstration program are reviewed and the Seasat spacecraft and its sensors (altimeter, wind field scatterometer, synthetic aperture radar, and scanning multichannel microwave radiometer) are described. The satellite data distribution system allows for selected sets of data, reformatted or tailored to specific needs and geographical regions, to be available to commercial users. Products include sea level and upper atmospheric pressure, sea surface temperature, marine winds, significant wave heights, primary wave direction and period, and spectral wave data. The results of a set of retrospective case studies performed for the commercial demonstration program are described. These are in areas of application such as marine weather and ocean condition forecasting, offshore resource exploration and development, commercial fishing, and marine transportation.

  6. Satellite Communications Using Commercial Protocols

    NASA Technical Reports Server (NTRS)

    Ivancic, William D.; Griner, James H.; Dimond, Robert; Frantz, Brian D.; Kachmar, Brian; Shell, Dan

    2000-01-01

    NASA Glenn Research Center has been working with industry, academia, and other government agencies in assessing commercial communications protocols for satellite and space-based applications. In addition, NASA Glenn has been developing and advocating new satellite-friendly modifications to existing communications protocol standards. This paper summarizes recent research into the applicability of various commercial standard protocols for use over satellite and space- based communications networks as well as expectations for future protocol development. It serves as a reference point from which the detailed work can be readily accessed. Areas that will be addressed include asynchronous-transfer-mode quality of service; completed and ongoing work of the Internet Engineering Task Force; data-link-layer protocol development for unidirectional link routing; and protocols for aeronautical applications, including mobile Internet protocol routing for wireless/mobile hosts and the aeronautical telecommunications network protocol.

  7. Application of text mining for customer evaluations in commercial banking

    NASA Astrophysics Data System (ADS)

    Tan, Jing; Du, Xiaojiang; Hao, Pengpeng; Wang, Yanbo J.

    2015-07-01

    Nowadays customer attrition is increasingly serious in commercial banks. To combat this problem roundly, mining customer evaluation texts is as important as mining customer structured data. In order to extract hidden information from customer evaluations, Textual Feature Selection, Classification and Association Rule Mining are necessary techniques. This paper presents all three techniques by using Chinese Word Segmentation, C5.0 and Apriori, and a set of experiments were run based on a collection of real textual data that includes 823 customer evaluations taken from a Chinese commercial bank. Results, consequent solutions, some advice for the commercial bank are given in this paper.

  8. A Statistical Analysis of the Economic Drivers of Battery Energy Storage in Commercial Buildings

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Long, Matthew; Simpkins, Travis; Cutler, Dylan

    There is significant interest in using battery energy storage systems (BESS) to reduce peak demand charges, and therefore the life cycle cost of electricity, in commercial buildings. This paper explores the drivers of economic viability of BESS in commercial buildings through statistical analysis. A sample population of buildings was generated, a techno-economic optimization model was used to size and dispatch the BESS, and the resulting optimal BESS sizes were analyzed for relevant predictor variables. Explanatory regression analyses were used to demonstrate that peak demand charges are the most significant predictor of an economically viable battery, and that the shape ofmore » the load profile is the most significant predictor of the size of the battery.« less

  9. Association of viable Mycobacterium leprae with Type 1 reaction in leprosy.

    PubMed

    Save, Mrudula Prakash; Dighe, Anju Rajaram; Natrajan, Mohan; Shetty, Vanaja Prabhakaran

    2016-03-01

    The working hypothesis is that, viable Mycobacterium leprae (M. leprae) play a crucial role in the precipitation of Type 1 reaction (T1R) in leprosy. A total of 165 new multibacillary patients were studied. To demonstrate presence of viable M. leprae in reactional lesion (T1R+), three tests were used concurrently viz. growth in the mouse foot pad (MFP), immunohistochemical detection of M. leprae secretory protein Ag85, and 16s rRNA--using in situ RT-PCR. Mirror biopsies and non reactional lesions served as controls (T1R-). A significantly higher proportion of lesion biopsy homogenates obtained at onset, from T1R(+) cases have shown unequivocal growth in MFP, proving the presence of viable bacteria, as compared to T1R(-) (P < 0.005). In contrast, few Mirror biopsies were positive in both T1R(+) and T1R(-). With respect to Ag85, while the overall positivity was higher in T1R(+) (74%), however the intensity of staining (Grade 2+) was disproportionately higher in T1R(+) BT-BB lesions 11/20 (55%). In the rebiopsies obtained during a repeat episode of T1R, Ag 85 as well as 16s rRNA, positivity (62% & 100%) was higher in T1R(+). It is inferred therefore 'viable' bacteria are an essential component in T1R and difference in the quality of bacilli, not the quantity or the ratio of dead to viable play a role in the precipitation of T1R. In conclusion, the findings show that 'metabolically active' M. leprae is a component/prerequisite and the secretory protein Ag 85, might be the trigger for precipitation of T1R.

  10. Viable adhered Staphylococcus aureus highly reduced on novel antimicrobial sutures using chlorhexidine and octenidine to avoid surgical site infection (SSI)

    PubMed Central

    Schneider, Jochen; Harrasser, Norbert; Tübel, Jutta; Mühlhofer, Heinrich; Pförringer, Dominik; von Deimling, Constantin; Foehr, Peter; Kiefel, Barbara; Krämer, Christina; Stemberger, Axel; Schieker, Matthias

    2018-01-01

    Background Surgical sutures can promote migration of bacteria and thus start infections. Antiseptic coating of sutures may inhibit proliferation of adhered bacteria and avoid such complications. Objectives This study investigated the inhibition of viable adhering bacteria on novel antimicrobially coated surgical sutures using chlorhexidine or octenidine, a critical factor for proliferation at the onset of local infections. The medical need, a rapid eradication of bacteria in wounds, can be fulfilled by a high antimicrobial efficacy during the first days after wound closure. Methods As a pretesting on antibacterial efficacy against relevant bacterial pathogens a zone of inhibition assay was conducted with middle ranged concentrated suture coatings (22 μg/cm). For further investigation of adhering bacteria in detail the most clinically relevant Staphylococcus aureus (ATCC®49230™) was used. Absorbable braided sutures were coated with chlorhexidine-laurate, chlorhexidine-palmitate, octenidine-laurate, and octenidine-palmitate. Each coating type resulted in 11, 22, or 33 μg/cm drug content on sutures. Scanning electron microscopy (SEM) was performed once to inspect the coating quality and twice to investigate if bacteria have colonized on sutures. Adhesion experiments were assessed by exposing coated sutures to S. aureus suspensions for 3 h at 37°C. Subsequently, sutures were sonicated and the number of viable bacteria released from the suture surface was determined. Furthermore, the number of viable planktonic bacteria was measured in suspensions containing antimicrobial sutures. Commercially available sutures without drugs (Vicryl®, PGA Resorba®, and Gunze PGA), as well as triclosan-containing Vicryl® Plus were used as control groups. Results Zone of inhibition assay documented a multispecies efficacy of novel coated sutures against tested bacterial strains, comparable to most relevant S. aureus over 48 hours. SEM pictures demonstrated uniform layers on

  11. The Viable Violinist.

    PubMed

    Hawking, Michael

    2016-06-01

    In the aftermath of the Kermit Gosnell trial and Giubilini and Minerva's article 'After-birth abortion', abortion-rights advocates have been pressured to provide an account of the moral difference between abortion, particularly late-term abortion, and infanticide. In response, some scholars have defended a moral distinction by appealing to an argument developed by Judith Jarvis Thomson in A defense of abortion. However, once Thomson's analogy is refined to account for the morally relevant features of late-term pregnancy, rather than distinguishing between late-term abortion and infanticide, it reinforces their moral similarity. This is because late-term abortion requires more than detachment - it requires an act of feticide to ensure the death of the viable fetus. As such, a Thomsonian account cannot be deployed successfully as a response to Giubilini and Minerva. Those wishing to defend late-term abortion while rejecting the permissibility of infanticide will need to provide an alternative account of the difference, or else accept Giubilini and Minerva's conclusion. © 2015 John Wiley & Sons Ltd.

  12. Native perennial forb tolerance to repeated annual applications of postemergence herbicides, 2009

    Treesearch

    Clinton C. Shock; Joey Ishida; Erik Feibert; Nancy Shaw

    2010-01-01

    Native forb seed is needed to restore rangelands of the Intermountain West. Commercial seed production is necessary to provide the quantity of seed needed for restoration efforts. A major limitation to economically viable commercial production of native forb seed is weed competition. Weeds are adapted to growing in disturbed soil, and native forbs are not competitive...

  13. Development and laboratory testing of a 138-kV PPP-insulated joint for commercial application

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Walldorf, S.P.; Chu, H.; Elbadaly, H.

    1990-04-01

    This paper describes the design, development and laboratory testing of a high voltage PPP (paper polypropylene/paper laminate) insulated joint for commercial application on 138-kV PPP-insulated cable. The design approach taken is conservative and addresses the typical variations in field conditions and in skill and workmanship of the splicing. Joint construction details, including choice of connector, taping structure, and joint mechanical reinforcement, are discussed. The test criteria are described and results are presented.

  14. Lease/Purchase: A Viable Alternative for Financing Schools.

    ERIC Educational Resources Information Center

    Demers, Denise

    1989-01-01

    Lease-purchase finance is a viable alternative for school districts that cannot or do not want to employ traditional financing techniques. Outlines the advantages and disadvantages of lease-purchase financing compared to outright purchase; operating leasing, which is taxable; and traditional tax-exempt bond financing. (MLF)

  15. Issues of organizational cybernetics and viability beyond Beer's viable systems model

    NASA Astrophysics Data System (ADS)

    Nechansky, Helmut

    2013-11-01

    The paper starts summarizing the claims of Beer's viable systems model to identify five issues any viable organizations has to deal with in an unequivocal hierarchical structure of five interrelated systems. Then the evidence is introduced for additional issues and related viable structures of organizations, which deviate from Beer's model. These issues are: (1) the establishment and (2) evolution of an organization; (3) systems for independent top-down control (like "Six Sigma"); (4) systems for independent bottom-up correction of performance problems (like "Kaizen"), both working outside a hierarchical structure; (5) pull production systems ("Just in Time") and (6) systems for checks and balances of top-level power (like boards and shareholder meetings). Based on that an evolutionary approach to organizational cybernetics is outlined, addressing the establishment of organizations and possible courses of developments, including recent developments in quality and production engineering, as well as problems of setting and changing goal values determining organizational policies.

  16. The BioStent: novel concept for a viable stent structure.

    PubMed

    Weinandy, Stefan; Rongen, Lisanne; Schreiber, Fabian; Cornelissen, Christian; Flanagan, Thomas Cormac; Mahnken, Andreas; Gries, Thomas; Schmitz-Rode, Thomas; Jockenhoevel, Stefan

    2012-09-01

    Percutaneous stenting of occluded peripheral vessels is a well-established technique in clinical practice. Unfortunately, the patency rates of small-caliber vessels after stenting remain unsatisfactory. The aim of the BioStent concept is to overcome in-stent restenosis by excluding the diseased vessel segment entirely from the blood stream, in addition to providing an intact endothelial cell layer. The concept combines the principles of vascular tissue engineering with a self-expanding stent: casting of the stent within a cellularized fibrin gel structure, followed by bioreactor conditioning, allows complete integration of the stent within engineered tissue. Small-caliber BioStents (Ø=6 mm; n=4) were produced by casting a nitinol stent within a thin fibrin/vascular smooth muscle cell (vSMC) mixture, followed by luminal endothelial cell seeding, and conditioning of the BioStent within a bioreactor system. The potential remodeling of the fibrin component into tissue was analyzed using routine histological methods. Scanning electron microscopy was used to assess the luminal endothelial cell coverage following the conditioning phase and crimping of the stent. The BioStent was shown to be noncytotoxic, with no significant effect on cell proliferation. Gross and microscopic analysis revealed complete integration of the nitinol component within a viable tissue structure. Hematoxylin and eosin staining revealed a homogenous distribution of vSMCs throughout the thickness of the BioStent, while a smooth, confluent luminal endothelial cell lining was evident and not significantly affected by the crimping/release process. The BioStent concept is a platform technology offering a novel opportunity to generate a viable, self-expanding stent structure with a functional endothelial cell lining. This platform technology can be transferred to different applications depending on the luminal cell lining required.

  17. Commercial Spacewalking: Designing an EVA Qualification Program for Space Tourism

    NASA Technical Reports Server (NTRS)

    Gast, Matthew A.

    2010-01-01

    In the near future, accessibility to space will be opened to anyone with the means and the desire to experience the weightlessness of microgravity, and to look out upon both the curvature of the Earth and the blackness of space, from the protected, shirt-sleeved environment of a commercial spacecraft. Initial forays will be short-duration, suborbital flights, but the experience and expertise of half a century of spaceflight will soon produce commercial vehicles capable of achieving low Earth orbit. Even with the commercial space industry still in its infancy, and manned orbital flight a number of years away, there is little doubt that there will one day be a feasible and viable market for those courageous enough to venture outside the vehicle and into the void, wearing nothing but a spacesuit, armed with nothing but preflight training. What that Extravehicular Activity (EVA) preflight training entails, however, is something that has yet to be defined. A number of significant factors will influence the composition of a commercial EVA training program, but a fundamental question remains: 'what minimum training guidelines must be met to ensure a safe and successful commercial spacewalk?' Utilizing the experience gained through the development of NASA's Skills program - designed to qualify NASA and International Partner astronauts for EVA aboard the International Space Station - this paper identifies the attributes and training objectives essential to the safe conduct of an EVA, and attempts to conceptually design a comprehensive training methodology meant to represent an acceptable qualification standard.

  18. Bulk-Heterojunction Organic Solar Cells: Five Core Technologies for Their Commercialization.

    PubMed

    Kang, Hongkyu; Kim, Geunjin; Kim, Junghwan; Kwon, Sooncheol; Kim, Heejoo; Lee, Kwanghee

    2016-09-01

    The past two decades of vigorous interdisciplinary approaches has seen tremendous breakthroughs in both scientific and technological developments of bulk-heterojunction organic solar cells (OSCs) based on nanocomposites of π-conjugated organic semiconductors. Because of their unique functionalities, the OSC field is expected to enable innovative photovoltaic applications that can be difficult to achieve using traditional inorganic solar cells: OSCs are printable, portable, wearable, disposable, biocompatible, and attachable to curved surfaces. The ultimate objective of this field is to develop cost-effective, stable, and high-performance photovoltaic modules fabricated on large-area flexible plastic substrates via high-volume/throughput roll-to-roll printing processing and thus achieve the practical implementation of OSCs. Recently, intensive research efforts into the development of organic materials, processing techniques, interface engineering, and device architectures have led to a remarkable improvement in power conversion efficiencies, exceeding 11%, which has finally brought OSCs close to commercialization. Current research interests are expanding from academic to industrial viewpoints to improve device stability and compatibility with large-scale printing processes, which must be addressed to realize viable applications. Here, both academic and industrial issues are reviewed by highlighting historically monumental research results and recent state-of-the-art progress in OSCs. Moreover, perspectives on five core technologies that affect the realization of the practical use of OSCs are presented, including device efficiency, device stability, flexible and transparent electrodes, module designs, and printing techniques. © 2016 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

  19. Future trends in commercial and military systems

    NASA Astrophysics Data System (ADS)

    Bond, F. E.

    Commercial and military satellite communication systems are addressed, with a review of current applications and typical communication characteristics of the space and earth segments. Drivers for the development of future commercial systems include: the pervasion of digital techniques and services, growing orbit and frequency congestion, demand for more entertainment, and the large potential market for commercial 'roof-top' service. For military systems, survivability, improved flexibility, and the need for service to small mobile terminals are the principal factors involved. Technical trends include the use of higher frequency bands, multibeam antennas and a significant increase in the application of onboard processing. Military systems will employ a variety of techniques to counter both physical and electronic threats. The use of redundant transmission paths is a particularly effective approach. Successful implementation requires transmission standards to achieve the required interoperability among the pertinent networks. For both the military and commercial sectors, the trend toward larger numbers of terminals and more complex spacecraft is still persisting.

  20. Pesticide Applicator Training Manual, Category 8B: Mosquito Control for New Jersey. A Training Program for the Certification of Commercial Pesticide Applicators, and Study Questions.

    ERIC Educational Resources Information Center

    Schulze, Terry L., Ed.; Kriner, Ray R., Ed.

    This training manual provides information needed to meet the mimimum EPA standards for certification as a commercial applicator of pesticides in the mosquito control category. The text discusses the aspects of mosquito biology and control by biological, mechanical, and integrated measures. A study guide with sample and study questions is included.…

  1. Advances in commercial application of gamma radiation in tropical fruits at Brazil

    NASA Astrophysics Data System (ADS)

    Sabato, S. F.; Silva, J. M.; Cruz, J. N.; Broisler, P. O.; Rela, P. R.; Salmieri, S.; Lacroix, M.

    2009-07-01

    All regions of Brazil are potential areas for growing tropical fruits. As this country is already a great producer and exporter of tropical fruits, ionizing radiation has been the subject of studies in many commodities. An important project has been carried out to increase the commercial use of gamma radiation in our country. Instituto de Pesquisas Energeticas e Nucleares (IPEN)-CNEN/SP together with field producers in northeast region and partners like International Atomic Energy Agency (IAEA), CIC, Empresa Brasileira Pesquisa na Agricultura (EMBRAPA) joined to demonstrate this technology, its application and commercial feasibility. The objective of this study is to show advances in feasibility demonstrate the quality of the irradiated fruits in an international consignment from Brazil to Canada. In this work, Tommy Atkins mangoes harvested in northeast region of Brazil were sent to Canada. The fruits were treated in a gamma irradiation facility at doses 0.4 and 1.0 kGy. The control group was submitted to hydrothermal treatment (46 °C for 110 min). The fruits were stored at 11 °C for 10 days until the international transportation and kept at an environmental condition (22 °C) for 12 days, where their physical-chemical and sensorial properties were evaluated. The financial part of the feasibility study covers the scope of the investment, including the net working capital and production costs.

  2. The Rise and Demise of Commercial Geography.

    ERIC Educational Resources Information Center

    Handley, Lawrence R.

    1982-01-01

    Commercial geography, originally taught in 18th-century trading schools, reached its zenith in the mid-1920s because it was stimulated by the development of the British Empire, noted for its commercial applications, and popularized through information disseminated by geographical societies. Demise factors include America's isolationist attitudes,…

  3. ATP as a biomarker of viable microorganisms in clean-room facilities

    NASA Technical Reports Server (NTRS)

    Venkateswaran, Kasthuri; Hattori, Noriaki; La Duc, Myron T.; Kern, Roger

    2003-01-01

    A new firefly luciferase bioluminescence assay method that differentiates free extracellular ATP (dead cells, etc.) from intracellular ATP (viable microbes) was used to determine the viable microbial cleanliness of various clean-room facilities. For comparison, samples were taken from both clean-rooms, where the air was filtered to remove particles >0.5 microm, and ordinary rooms with unfiltered air. The intracellular ATP was determined after enzymatically degrading the sample's free ATP. Also for comparison, cultivable microbial populations were counted on nutrient-rich trypticase soy agar (TSA) plates. Both the cultivable and ATP-based determinations indicate that the microbial burden was lower in clean-room facilities than in ordinary rooms. However, there was no direct correlation between the two sets of measurements because the two assays measured very different populations. A large fraction of the samples yielded no colony formers on TSA, but were positive for intracellular ATP. Subsequently, genomic DNA was isolated directly from selected samples and 16S rDNA fragments were cloned and sequenced, identifying nearest neighbors, many of which are known to be noncultivable in the media employed. It was concluded that viable microbial contamination can be reliably monitored by measurement of intracellular ATP, and that this method may be considered superior to cultivable colony counts due to its speed and its ability to report the presence of viable but noncultivable organisms. When the detection of nonviable microbes is of interest, the ATP assay can be supplemented with DNA analysis.

  4. ATP as a biomarker of viable microorganisms in clean-room facilities.

    PubMed

    Venkateswaran, Kasthuri; Hattori, Noriaki; La Duc, Myron T; Kern, Roger

    2003-03-01

    A new firefly luciferase bioluminescence assay method that differentiates free extracellular ATP (dead cells, etc.) from intracellular ATP (viable microbes) was used to determine the viable microbial cleanliness of various clean-room facilities. For comparison, samples were taken from both clean-rooms, where the air was filtered to remove particles >0.5 microm, and ordinary rooms with unfiltered air. The intracellular ATP was determined after enzymatically degrading the sample's free ATP. Also for comparison, cultivable microbial populations were counted on nutrient-rich trypticase soy agar (TSA) plates. Both the cultivable and ATP-based determinations indicate that the microbial burden was lower in clean-room facilities than in ordinary rooms. However, there was no direct correlation between the two sets of measurements because the two assays measured very different populations. A large fraction of the samples yielded no colony formers on TSA, but were positive for intracellular ATP. Subsequently, genomic DNA was isolated directly from selected samples and 16S rDNA fragments were cloned and sequenced, identifying nearest neighbors, many of which are known to be noncultivable in the media employed. It was concluded that viable microbial contamination can be reliably monitored by measurement of intracellular ATP, and that this method may be considered superior to cultivable colony counts due to its speed and its ability to report the presence of viable but noncultivable organisms. When the detection of nonviable microbes is of interest, the ATP assay can be supplemented with DNA analysis.

  5. A Statistical Analysis of the Economic Drivers of Battery Energy Storage in Commercial Buildings: Preprint

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Long, Matthew; Simpkins, Travis; Cutler, Dylan

    There is significant interest in using battery energy storage systems (BESS) to reduce peak demand charges, and therefore the life cycle cost of electricity, in commercial buildings. This paper explores the drivers of economic viability of BESS in commercial buildings through statistical analysis. A sample population of buildings was generated, a techno-economic optimization model was used to size and dispatch the BESS, and the resulting optimal BESS sizes were analyzed for relevant predictor variables. Explanatory regression analyses were used to demonstrate that peak demand charges are the most significant predictor of an economically viable battery, and that the shape ofmore » the load profile is the most significant predictor of the size of the battery.« less

  6. Commercial technologies from the SP-100 program

    NASA Astrophysics Data System (ADS)

    Truscello, Vincent C.; Fujita, Toshio; Mondt, Jack F.

    1995-01-01

    For more than a decade, the Jet Propulsion Labortory (JPL) and Los Alamos National Laboratory (LANL) have managed a multi-agency funded effort to develop a space reactor power system. This SP-100 Program has developed technologies required for space power systems that can be implemented in the industrial and commercial sectors to improve our competitiveness in the global economy. Initial steps taken to transfer this technology from the laboratories to industrial and commercial entities within the United States include: (1) identifying specific technologies having commercial potential; (2) distributing information describing the identified technologies and interacting with interested commercial and industrial entities to develop application-specific details and requirements; and (3) providing a technological data base that leads to transfer of technology or the forming of teaming arrangements to accomplish the transfer by tailoring the technology to meet application-specific requirements. SP-100 technologies having commercial potential encompass fabrication processes, devices, and components. Examples are a process for bonding refractory metals to graphite, a device to sense the position of an actuator and a component to enable rotating machines to operate without supplying lubrication ( a self-lubricating ball bearing). Shortly after the National Aeronautics and Space Administration (NASA) Regional Technology Transfer Centers widely disseminated information covering SP-100 technologies, over one hundred expressions of interest were received. These early responses indicate that there is a large potential benefit in transferring SP-100 technology. Interactions with industrial and commercial entities have identified a substantial need for creating teaming arrangements involving the interested entity and personnel from laboratories and their contractors, who have the knowledge and ability to tailor the technology to meet application-specific requirements.

  7. Sensitive and Rapid Detection of Viable Giardia Cysts and Cryptosporidium parvum Oocysts in Large-Volume Water Samples with Wound Fiberglass Cartridge Filters and Reverse Transcription-PCR

    PubMed Central

    Kaucner, Christine; Stinear, Timothy

    1998-01-01

    We recently described a reverse transcription-PCR (RT-PCR) for detecting low numbers of viable Cryptosporidium parvum oocysts spiked into clarified environmental water concentrates. We have now modified the assay for direct analysis of primary sample concentrates with simultaneous detection of viable C. parvum oocysts, Giardia cysts, and a novel type of internal positive control (IPC). The IPC was designed to assess both efficiency of mRNA isolation and potential RT-PCR inhibition. Sensitivity testing showed that low numbers of organisms, in the range of a single viable cyst and oocyst, could be detected when spiked into 100-μl packed pellet volumes of concentrates from creek and river water samples. The RT-PCR was compared with an immunofluorescence (IF) assay by analyzing 29 nonspiked environmental water samples. Sample volumes of 20 to 1,500 liters were concentrated with a wound fiberglass cartridge filter. Frequency of detection for viable Giardia cysts increased from 24% by IF microscopy to 69% by RT-PCR. Viable C. parvum oocysts were detected only once by RT-PCR (3%) in contrast to detection of viable Cryptosporidium spp. in four samples by IF microscopy (14%), suggesting that Cryptosporidium species other than C. parvum were present in the water. This combination of the large-volume sampling method with RT-PCR represents a significant advance in terms of protozoan pathogen monitoring and in the wider application of PCR technology to this field of microbiology. PMID:9572946

  8. Commercial future: making remote sensing a media event

    NASA Astrophysics Data System (ADS)

    Lurie, Ian

    1999-12-01

    The rapid growth of commercial remote sensing has made high quality digital sensing data widely available -- now, remote sensing must become and remain a strong, commercially viable industry. However, this new industry cannot survive without an educated consumer base. To access markets, remote sensing providers must make their product more accessible, both literally and figuratively: Potential customers must be able to find the data they require, when they require it, and they must understand the utility of the information available to them. The Internet and the World Wide Web offer the perfect medium to educate potential customers and to sell remote sensing data to those customers. A well-designed web presence can provide both an information center and a market place for companies offering their data for sale. A very high potential web-based market for remote sensing lies in media. News agencies, web sites, and a host of other visual media services can use remote sensing data to provide current, relevant information regarding news around the world. This paper will provide a model for promotion and sale of remote sensing data via the Internet.

  9. InfraCAM (trade mark): A Hand-Held Commercial Infrared Camera Modified for Spaceborne Applications

    NASA Technical Reports Server (NTRS)

    Manitakos, Daniel; Jones, Jeffrey; Melikian, Simon

    1996-01-01

    In 1994, Inframetrics introduced the InfraCAM(TM), a high resolution hand-held thermal imager. As the world's smallest, lightest and lowest power PtSi based infrared camera, the InfraCAM is ideal for a wise range of industrial, non destructive testing, surveillance and scientific applications. In addition to numerous commercial applications, the light weight and low power consumption of the InfraCAM make it extremely valuable for adaptation to space borne applications. Consequently, the InfraCAM has been selected by NASA Lewis Research Center (LeRC) in Cleveland, Ohio, for use as part of the DARTFire (Diffusive and Radiative Transport in Fires) space borne experiment. In this experiment, a solid fuel is ignited in a low gravity environment. The combustion period is recorded by both visible and infrared cameras. The infrared camera measures the emission from polymethyl methacrylate, (PMMA) and combustion products in six distinct narrow spectral bands. Four cameras successfully completed all qualification tests at Inframetrics and at NASA Lewis. They are presently being used for ground based testing in preparation for space flight in the fall of 1995.

  10. Applications of commercial biosensors in clinical, food, environmental, and biothreat/biowarfare analyses.

    PubMed

    Bahadır, Elif Burcu; Sezgintürk, Mustafa Kemal

    2015-06-01

    The lack of specific, low-cost, rapid, sensitive, and easy detection of biomolecules has resulted in the development of biosensor technology. Innovations in biosensor technology have enabled many biosensors to be commercialized and have enabled biomolecules to be detected onsite. Moreover, the emerging technologies of lab-on-a-chip microdevices and nanosensors offer opportunities for the development of new biosensors with much better performance. Biosensors were first introduced into the laboratory by Clark and Lyons. They developed the first glucose biosensor for laboratory conditions. Then in 1973, a glucose biosensor was commercialized by Yellow Springs Instruments. The commercial biosensors have small size and simple construction and they are ideal for point-of-care biosensing. In addition to glucose, a wide variety of metabolites such as lactate, cholesterol, and creatinine can be detected by using commercial biosensors. Like the glucose biosensors (tests) other commercial tests such as for pregnancy (hCG), Escherichia coli O157, influenza A and B viruses, Helicobacter pylori, human immunodeficiency virus, tuberculosis, and malaria have achieved success. Apart from their use in clinical analysis, commercial tests are also used in environmental (such as biochemical oxygen demand, nitrate, pesticide), food (such as glutamate, glutamine, sucrose, lactose, alcohol, ascorbic acid), and biothreat/biowarfare (Bacillus anthracis, Salmonella, Botulinum toxin) analysis. In this review, commercial biosensors in clinical, environmental, food, and biowarfare analysis are summarized and the commercial biosensors are compared in terms of their important characteristics. This is the first review in which all the commercially available tests are compiled together. Copyright © 2015 Elsevier Inc. All rights reserved.

  11. Kentucky commercial vehicle safety applications evaluation : technical report.

    DOT National Transportation Integrated Search

    2008-01-31

    An advanced-technology Integrated Safety and Security Enforcement System (ISSES), now deployed at three commercial vehicle inspection sites along interstate highways in Kentucky, was evaluated from the point of view of system performance, potential e...

  12. Pesticide Applicator Training Manual, Category 7B: Termites and Other Wood Destroying Pests. A Training Program for the Certification of Commercial Pesticide Applicators, and Study Questions.

    ERIC Educational Resources Information Center

    Schmitt, John B.

    This training manual provides information needed to meet the minimum EPA standards for certification as a commercial applicator of pesticides in the termite and wood destroying pest control category. The text discusses the importance, description, biology, and control of termites, powderpost beetles, house and warf borers, carpenter ants, and…

  13. Membrane Lipids as Indicators for Viable Bacterial Communities Inhabiting Petroleum Systems.

    PubMed

    Gruner, Andrea; Mangelsdorf, Kai; Vieth-Hillebrand, Andrea; Horsfield, Brian; van der Kraan, Geert M; Köhler, Thomas; Janka, Christoph; Morris, Brandon E L; Wilkes, Heinz

    2017-08-01

    Microbial activity in petroleum reservoirs has been implicated in a suite of detrimental effects including deterioration of petroleum quality, increases in oil sulfur content, biofouling of steel pipelines and other infrastructures, and well plugging. Here, we present a biogeochemical approach, using phospholipid fatty acids (PLFAs), for detecting viable bacteria in petroleum systems. Variations within the bacterial community along water flow paths (producing well, topside facilities, and injection well) can be elucidated in the field using the same technique, as shown here within oil production plants in the Molasse Basin of Upper Austria. The abundance of PLFAs is compared to total cellular numbers, as detected by qPCR of the 16S rDNA gene, to give an overall comparison between the resolutions of both methods in a true field setting. Additionally, the influence of biocide applications on lipid- and DNA-based quantification was investigated. The first oil field, Trattnach, showed significant PLFA abundances and cell numbers within the reservoir and topside facilities. In contrast, the second field (Engenfeld) showed very low PLFA levels overall, likely due to continuous treatment of the topside facilities with a glutaraldehyde-based antimicrobial. In comparison, Trattnach is dosed once per week in a batch fashion. Changes within PLFA compositions across the flow path, throughout the petroleum production plants, point to cellular adaptation within the system and may be linked to shifts in the dominance of certain bacterial types in oil reservoirs versus topside facilities. Overall, PLFA-based monitoring provides a useful tool to assess the abundance and high-level taxonomic diversity of viable microbial populations in oil production wells, topside infrastructure, pipelines, and other related facilities.

  14. 50 CFR 622.278 - Commercial trip limits.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... ADMINISTRATION, DEPARTMENT OF COMMERCE FISHERIES OF THE CARIBBEAN, GULF OF MEXICO, AND SOUTH ATLANTIC Dolphin and Wahoo Fishery Off the Atlantic States § 622.278 Commercial trip limits. Commercial trip limits are... in this section with any trip or possession limit applicable to state waters. A species subject to a...

  15. 50 CFR 622.278 - Commercial trip limits.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... ADMINISTRATION, DEPARTMENT OF COMMERCE FISHERIES OF THE CARIBBEAN, GULF OF MEXICO, AND SOUTH ATLANTIC Dolphin and Wahoo Fishery Off the Atlantic States § 622.278 Commercial trip limits. Commercial trip limits are... in this section with any trip or possession limit applicable to state waters. A species subject to a...

  16. A viable dipole magnet concept with REBCO CORC® wires and further development needs for high-field magnet applications

    NASA Astrophysics Data System (ADS)

    Wang, Xiaorong; Caspi, Shlomo; Dietderich, Daniel R.; Ghiorso, William B.; Gourlay, Stephen A.; Higley, Hugh C.; Lin, Andy; Prestemon, Soren O.; van der Laan, Danko; Weiss, Jeremy D.

    2018-04-01

    REBCO coated conductors maintain a high engineering current density above 16 T at 4.2 K. That fact will significantly impact markets of various magnet applications including high-field magnets for high-energy physics and fusion reactors. One of the main challenges for the high-field accelerator magnet is the use of multi-tape REBCO cables with high engineering current density in magnet development. Several approaches developing high-field accelerator magnets using REBCO cables are demonstrated. In this paper, we introduce an alternative concept based on the canted cos θ (CCT) magnet design using conductor on round core (CORC®) wires that are wound from multiple REBCO tapes with a Cu core. We report the development and test of double-layer three-turn CCT dipole magnets using CORC® wires at 77 and 4.2 K. The scalability of the CCT design allowed us to effectively develop and demonstrate important magnet technology features such as coil design, winding, joints and testing with minimum conductor lengths. The test results showed that the CCT dipole magnet using CORC® wires was a viable option in developing a REBCO accelerator magnet. One of the critical development needs is to increase the engineering current density of the 3.7 mm diameter CORC® wire to 540 A mm-2 at 21 T, 4.2 K and to reduce the bending radius to 15 mm. This would enable a compact REBCO dipole insert magnet to generate a 5 T field in a background field of 16 T at 4.2 K.

  17. A Comprehensive Assessment of Biologicals Contained Within Commercial Airliner Cabin Air

    NASA Technical Reports Server (NTRS)

    LaDuc, Myron T.; Osman, Shariff; Dekas, Anne; Stuecker, Tara; Newcombe, Dave; Piceno, Yvette; Fuhrman, J.; Andersen, Gary; Venkateswaran, Kasthuri; Bearman, Greg

    2006-01-01

    Both culture-based and culture-independent, biomarker-targeted microbial enumeration and identification technologies were employed to estimate total microbial and viral burden and diversity within the cabin air of commercial airliners. Samples from each of twenty flights spanning three commercial carriers were collected via air-impingement. When the total viable microbial population was estimated by assaying relative concentrations of the universal energy carrier ATP, values ranged from below detection limits (BDL) to 4.1 x 106 cells/cubic m of air. The total viable microbial population was extremely low in both of Airline A (approximately 10% samples) and C (approximately 18% samples) compared to the samples collected aboard flights on Airline A and B (approximately 70% samples). When samples were collected as a function of time over the course of flights, a gradual accumulation of microbes was observed from the time of passenger boarding through mid-flight, followed by a sharp decline in microbial abundance and viability from the initiation of descent through landing. It is concluded in this study that only 10% of the viable microbes of the cabin air were cultivable and suggested a need to employ state-of-the art molecular assay that measures both cultivable and viable-but-non-cultivable microbes. Among the cultivable bacteria, colonies of Acinetobacter sp. were by far the most profuse in Phase I, and Gram-positive bacteria of the genera Staphylococcus and Bacillus were the most abundant during Phase II. The isolation of the human pathogens Acinetobacter johnsonii, A. calcoaceticus, Janibacter melonis, Microbacterium trichotecenolyticum, Massilia timonae, Staphylococcus saprophyticus, Corynebacterium lipophiloflavum is concerning, as these bacteria can cause meningitis, septicemia, and a handful of sometimes fatal diseases and infections. Molecular microbial community analyses exhibited presence of the alpha-, beta-, gamma-, and delta- proteobacteria, as well as

  18. Purity assessment of commercial zein products after purification

    USDA-ARS?s Scientific Manuscript database

    Successful utilization of commercial zein products for certain food, pharmaceutical, cosmetic and medical applications requires a decolorized/deodorized zein of high purity. A zein protein product with those qualifications can be achieved by column filtration of commercial yellow zein solutions thro...

  19. Commercialization of nanotechnology.

    PubMed

    Hobson, David W

    2009-01-01

    The emerging and potential commercial applications of nanotechnologies clearly have great potential to significantly advance and even potentially revolutionize various aspects of medical practice and medical product development. Nanotechnology is already touching upon many aspects of medicine, including drug delivery, diagnostic imaging, clinical diagnostics, nanomedicines, and the use of nanomaterials in medical devices. This technology is already having an impact; many products are on the market and a growing number is in the pipeline. Momentum is steadily building for the successful development of additional nanotech products to diagnose and treat disease; the most active areas of product development are drug delivery and in vivo imaging. Nanotechnology is also addressing many unmet needs in the pharmaceutical industry, including the reformulation of drugs to improve their bioavailability or toxicity profiles. The advancement of medical nanotechnology is expected to advance over at least three different generations or phases, beginning with the introduction of simple nanoparticulate and nanostructural improvements to current product and process types, then eventually moving on to nanoproducts and nanodevices that are limited only by the imagination and limits of the technology itself. This review looks at some recent developments in the commercialization of nanotechnology for various medical applications as well as general trends in the industry, and explores the nanotechnology industry that is involved in developing medical products and procedures with a view toward technology commercialization. (c) 2009 John Wiley & Sons, Inc.

  20. Transitioning glass-ceramic scintillators for diagnostic x-ray imaging from the laboratory to commercial scale

    NASA Astrophysics Data System (ADS)

    Beckert, M. Brooke; Gallego, Sabrina; Elder, Eric; Nadler, Jason

    2016-10-01

    This study sought to mitigate risk in transitioning newly developed glass-ceramic scintillator technology from a laboratory concept to commercial product by identifying the most significant hurdles to increased scale. These included selection of cost effective raw material sources, investigation of process parameters with the most significant impact on performance, and synthesis steps that could see the greatest benefit from participation of an industry partner that specializes in glass or optical component manufacturing. Efforts focused on enhancing the performance of glass-ceramic nanocomposite scintillators developed specifically for medical imaging via composition and process modifications that ensured efficient capture of incident X-ray energy and emission of scintillation light. The use of cost effective raw materials and existing manufacturing methods demonstrated proof-of-concept for economical viable alternatives to existing benchmark materials, as well as possible disruptive applications afforded by novel geometries and comparatively lower cost per volume. The authors now seek the expertise of industry to effectively navigate the transition from laboratory demonstrations to pilot scale production and testing to evince the industry of the viability and usefulness of composite-based scintillators.

  1. Principles and application of high pressure-based technologies in the food industry.

    PubMed

    Balasubramaniam, V M Bala; Martínez-Monteagudo, Sergio I; Gupta, Rockendra

    2015-01-01

    High pressure processing (HPP) has emerged as a commercially viable food manufacturing tool that satisfies consumers' demand for mildly processed, convenient, fresh-tasting foods with minimal to no preservatives. Pressure treatment, with or without heat, inactivates pathogenic and spoilage bacteria, yeast, mold, viruses, and also spores and extends shelf life. Pressure treatment at ambient or chilled temperatures has minimal impact on product chemistry. The product quality and shelf life are often influenced more by storage conditions and packaging material barrier properties than the treatment itself. Application of pressure reduces the thermal exposure of the food during processing, thereby protecting a variety of bioactive compounds. This review discusses recent scientific advances of high pressure technology for food processing and preservation applications such as pasteurization, sterilization, blanching, freezing, and thawing. We highlight the importance of in situ engineering and thermodynamic properties of food and packaging materials in process design. Current and potential future promising applications of pressure technology are summarized.

  2. Proceedings of the 2006 Civil Commercial Imagery Evaluation Workshop

    NASA Technical Reports Server (NTRS)

    Stanley, Thomas; Pagnutti, Mary

    2007-01-01

    The Joint Agency Commercial Imagery Evaluation (JACIE) team is a collaborative interagency working group formed to leverage different government agencies' capabilities for the characterization of commercial remote sensing products. The team is composed of staff from the National Aeronautics and Space Administration (NASA), the National Geospatial-Intelligence Agency (NGA), and the U.S. Geological Survey (USGS). Each JACIE agency has a vested interest in the purchase and use of commercial imagery to support government research and operational applications. The intent of the 2006 workshop is to exchange information regarding the characterization and application of commercial imagery used by the government. The main focus of previous workshops has been on high-resolution satellite imagery from systems; such as, IKONOS (Space Imaging, Inc.), QuickBird (DigitalGlobe, Inc.), and OrbView-3 (ORBIMAGE). This workshop is being expanded to cover all civil medium- and high-resolution commercial imagery used by the government.

  3. 50 CFR 622.43 - Commercial trip limits.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... ADMINISTRATION, DEPARTMENT OF COMMERCE FISHERIES OF THE CARIBBEAN, GULF OF MEXICO, AND SOUTH ATLANTIC Reef Fish Resources of the Gulf of Mexico § 622.43 Commercial trip limits. Commercial trip limits are limits on the... with any trip or possession limit applicable to state waters. A species subject to a trip limit...

  4. LEDs for solid state lighting and other emerging applications: status, trends, and challenges

    NASA Astrophysics Data System (ADS)

    Craford, M. George

    2005-09-01

    LEDs have been commercially available since the 1960's, but in recent years there have been remarkable improvements in performance. These technology developments have enabled the use of LEDs in a variety of colored and white lighting applications. Colored LEDs have already become the technology of choice for traffic signals, much of interior and exterior vehicle lighting, signage of various types often as a replacement for neon, and other areas. LEDs are expected to become the dominant technology for most colored lighting applications. LEDs are beginning to penetrate white lighting markets such as flashlights and localized task lighting. With further improvement LEDs have the potential to become an important technology for large area general illumination. White LED products already have performance of over 30 lumens/watt which is nearly 3x better than incandescents. White LEDs with outputs of more than 100 lumens are already available commercially, and higher power devices can be expected in the near future. LEDs can be used as point sources, or can be used with light guides of various types to provide distributed illumination. Developments that will need to occur for LEDs to be viable for large area general illumination are discussed.

  5. 48 CFR 2131.103 - Contracts with commercial organizations.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 48 Federal Acquisition Regulations System 6 2010-10-01 2010-10-01 true Contracts with commercial organizations. 2131.103 Section 2131.103 Federal Acquisition Regulations System OFFICE OF PERSONNEL MANAGEMENT... CONTRACT COST PRINCIPLES AND PROCEDURES Applicability 2131.103 Contracts with commercial organizations. The...

  6. A simple and efficient method for cryopreservation and recovery of viable Plasmodium vivax and P. falciparum sporozoites.

    PubMed

    Singh, Naresh; Barnes, Samantha J; Jenwithisuk, Rachaneeporn; Sattabongkot, Jetsumon; Adams, John H

    2016-10-01

    Plasmodium falciparum and Plasmodium vivax sporozoites are the crucial stages of malaria parasites that initiate infection in humans. However, studies to develop new vaccines and drugs targeting these infective stages remain insufficient due to limited availability of sporozoites for research. This is a consequence of relatively few facilities that are established to produce sporozoites of human malaria parasites, sporozoites remaining viable for only a few days, and infected mosquitoes being a biohazard, making them difficult to transport. Cryopreservation of sporozoites offers the potential to alleviate these limitations and enhance sporozoite availability. These experiments were performed to evaluate methods for cryopreservation of P. vivax and P. falciparum sporozoites. Sporozoites, isolated in sterile buffer from infected mosquitoes by manual dissection of salivary glands, were cryopreserved using several types of commercially available serum-free cryoprotective solutions. The efficiency of cryopreservation was validated by a standard in vitro gliding motility assay as a measure of sporozoite activity. Viability of infective sporozoites was defined as percent gliding of sporozoites attached to the coverslip. Significant differences were observed among the cryopreservation media and protocols evaluated, with CryoStor CS2 giving the best results for both P. falciparum and P. vivax, whereas Hestar 200 worked efficiently only for P. vivax sporozoites. Further improvement in recovery of viable sporozoites would be anticipated using automated controlled-rate freezing equipment. Our results demonstrate that cryopreservation provides an alternative for experimental studies that currently rely on fresh P. falciparum and P. vivax sporozoites. Copyright © 2015 Elsevier Ireland Ltd. All rights reserved.

  7. Optimization of PMA-qPCR for Staphylococcus aureus and determination of viable bacteria in indoor air.

    PubMed

    Chang, C-W; Lin, M-H

    2018-01-01

    Staphylococcus aureus may cause infections in humans from mild skin disorders to lethal pneumonia. Rapid and accurate monitoring of viable S. aureus is essential to characterize human exposure. This study evaluated quantitative PCR (qPCR) with propidium monoazide (PMA) to quantify S. aureus. The results showed comparable S. aureus counts between exclusively live cells and mixtures of live/dead cells by qPCR with 1.5 or 2.3 μg/mL PMA (P>.05), illustrating the ability of PMA-qPCR to detect DNA exclusively from viable cells. Moreover, qPCR with 1.5 or 2.3 μg/mL PMA performed optimally with linearity over 10 3 -10 8  CFU/mL (R 2 ≥0.9), whereas qPCR with 10, 23 or 46 μg/mL PMA significantly underestimated viable counts. Staphylococcus aureus and total viable bacteria were further determined with PMA-qPCR (1.5 μg/mL) from 48 samples from a public library and two university dormitories and four from outside. Viable bacteria averaged 1.9×10 4 cells/m 3 , and S. aureus were detected in 22 (42%) samples with a mean of 4.4×10 3 cells/m 3 . The number of S. aureus and viable bacteria were positively correlated (r=.61, P<.005), and percentages of S. aureus relative to viable bacteria averaged 12-44%. The results of field samples suggest that PMA-qPCR can be used to quantify viable S. aureus cells. © 2017 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

  8. Use of commercial soil amendments in initial soils (II) - Impact on soil respiratory and carbon isotopic characteristics

    NASA Astrophysics Data System (ADS)

    Nii-Annang, S.; Rodionov, A.; Dilly, O.; Bens, O.; Raab, T.; Hüttl, R. F.

    2009-04-01

    The search for viable re-cultivation techniques for the reclamation of large scale soil disturbances induced by mining of mineral resources has increasingly received attention in recent times. These techniques should favour plant growth under dry conditions and under nutrient-poor substrates; a problem in the lignite mining district in Lusatia, Germany. Substrates with basal respiration around 0.04 µg CO2 g-1 h-1, which is relatively low compared to mature soils, were amended with two nutrient rich commercial soil additives (CSA 1 and CSA 2). The CSA 1 is a synthetic-mineral mixture and CSA 2 an organo-mineral mixture. The amendment stimulated basal respiration based on both carbon dioxide evolution and oxygen uptake by 150 and 125 % for SCA 1 and CSA 2, respectively when 1 % of each additive was thoroughly mixed with substrate in a laboratory study. The stimulating effect was evident after glucose addition to CSA 2. The CSA 1 application in the field at lower rates still showed apparent stimulation of soil respiratory activities after one year. Similarly, the organo-mineral-mixture has prominent effects on basal respiration and substrate-induced respiration when glucose was added. We concluded that the commercial additives used as long-term amelioration techniques increased both nutrient preservation and, to some extent, soil microbial activity.

  9. Applications of magnetic resonance spectroscopy to chitin from insect cuticles.

    PubMed

    Gonil, Pattarapond; Sajomsang, Warayuth

    2012-11-01

    Chitin is the second most abundant polysaccharide in nature after cellulose. At the present time, the main commercial sources of chitin are the crab and shrimp shells which are major waste products from the seafood industry. However, current chitin resources have some inherent problems including seasonal availability, limited supplies, and environmental pollution. As an alternative, insect cuticle is proposed as an unconventional but viable source of chitin. This review focuses on the recent sources of insect chitin and the application of various magnetic resonance spectroscopic techniques to native insect cuticles, particularly cicada sloughs and chitin extracted from insect sloughs. In addition, the physicochemical properties, isolation process, and degree of N-acetylation (DA) is reviewed and discussed. Copyright © 2012 Elsevier B.V. All rights reserved.

  10. High speed flow cytometric separation of viable cells

    DOEpatents

    Sasaki, D.T.; Van den Engh, G.J.; Buckie, A.M.

    1995-11-14

    Hematopoietic cell populations are separated to provide cell sets and subsets as viable cells with high purity and high yields, based on the number of original cells present in the mixture. High-speed flow cytometry is employed using light characteristics of the cells to separate the cells, where high flow speeds are used to reduce the sorting time.

  11. High speed flow cytometric separation of viable cells

    DOEpatents

    Sasaki, Dennis T.; Van den Engh, Gerrit J.; Buckie, Anne-Marie

    1995-01-01

    Hematopoietic cell populations are separated to provide cell sets and subsets as viable cells with high purity and high yields, based on the number of original cells present in the mixture. High-speed flow cytometry is employed using light characteristics of the cells to separate the cells, where high flow speeds are used to reduce the sorting time.

  12. Trans-resveratrol and beta-carotene from sunscreens penetrate viable skin layers and reduce cutaneous penetration of UV-filters.

    PubMed

    Freitas, J V; Praça, F S G; Bentley, M V L B; Gaspar, L R

    2015-04-30

    Cutaneous permeation is a critical parameter when topical application of sunscreens containing antioxidants is considered. The aim of this study was to evaluate the cutaneous penetration of most marketed UV-filters combined with trans-resveratrol (RES) and beta-carotene (BTC) since few studies report skin penetration when such compounds are applied. Formulations containing octocrylene, octyl methoxycinnamate, avobenzone and bemotrizinole were prepared and supplemented or not with BTC, or with RES, or with both compounds in combination. Penetration studies were performed using Franz vertical diffusion cells and porcine ear skin as the biological membrane. The quantification of UV-filters and antioxidants in the stratum corneum (SC), viable epidermis plus dermis and receptor fluid was performed by HPLC. Results suggested that UV-filters and antioxidants did not permeate the skin but were retained for 12h post application. About 90% and 80%, respectively, of the total penetrated amount of UV-filters and antioxidants was found in the SC. Interestingly, it was observed that BTC, alone or combined with RES, reduced the skin retention of UV-filters on average by 63%. In conclusion, this study demonstrated that the combination of antioxidants and UV-filters in sunscreens is advantageous for cutaneous penetration, since BTC and BTC+RES improved sunscreen safety by reducing delivery of the four UV-filters in the study into SC and viable epidermis. Copyright © 2015 Elsevier B.V. All rights reserved.

  13. Commercialization of Plasma-Assisted Technologies: The Indian Experience

    NASA Astrophysics Data System (ADS)

    John, P. I.

    The paper describes an initiative by the Institute for Plasma Research (IPR), India in establishing links with the Indian industry for developing and commercialising advanced plasma-based industrial technologies. This has culminated in the creation of a self-financing technology development, incubation, demonstration and delivery facility. A business plan for converting the knowledge base to commercially viable technologies conceived technology as a product and the industry as the market and addressed issues like resistance to new technologies, the key role of entrepreneur, thrust areas and the necessity of technology incubation and delivery. Success of this strategy is discussed in a few case studies. We conclude by identifying the cost, environmental, strategic and techno-economic aspects, which would be the prime drivers for plasma-assisted manufacturing technology in India.

  14. 49 CFR 383.91 - Commercial motor vehicle groups.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 49 Transportation 5 2012-10-01 2012-10-01 false Commercial motor vehicle groups. 383.91 Section... DRIVER'S LICENSE STANDARDS; REQUIREMENTS AND PENALTIES Vehicle Groups and Endorsements § 383.91 Commercial motor vehicle groups. (a) Vehicle group descriptions. Each driver applicant must possess and be...

  15. 49 CFR 383.91 - Commercial motor vehicle groups.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 49 Transportation 5 2013-10-01 2013-10-01 false Commercial motor vehicle groups. 383.91 Section... DRIVER'S LICENSE STANDARDS; REQUIREMENTS AND PENALTIES Vehicle Groups and Endorsements § 383.91 Commercial motor vehicle groups. (a) Vehicle group descriptions. Each driver applicant must possess and be...

  16. 49 CFR 383.91 - Commercial motor vehicle groups.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 49 Transportation 5 2014-10-01 2014-10-01 false Commercial motor vehicle groups. 383.91 Section... DRIVER'S LICENSE STANDARDS; REQUIREMENTS AND PENALTIES Vehicle Groups and Endorsements § 383.91 Commercial motor vehicle groups. (a) Vehicle group descriptions. Each driver applicant must possess and be...

  17. Evidence for viable, non-clonal but fatherless Boa constrictors.

    PubMed

    Booth, Warren; Johnson, Daniel H; Moore, Sharon; Schal, Coby; Vargo, Edward L

    2011-04-23

    Parthenogenesis in vertebrates is considered an evolutionary novelty. In snakes, all of which exhibit genetic sex determination with ZZ : ZW sex chromosomes, this rare form of asexual reproduction has failed to yield viable female WW offspring. Only through complex experimental manipulations have WW females been produced, and only in fish and amphibians. Through microsatellite DNA fingerprinting, we provide the first evidence of facultative parthenogenesis in a Boa constrictor, identifying multiple, viable, non-experimentally induced females for the first time in any vertebrate lineage. Although the elevated homozygosity of the offspring in relation to the mother suggests that the mechanism responsible may be terminal fusion automixis, no males were produced, potentially indicating maternal sex chromosome hemizygosity (WO). These findings provide the first evidence of parthenogenesis in the family Boidae (Boas), and suggest that WW females may be more common within basal reptilian lineages than previously assumed.

  18. Evidence for viable, non-clonal but fatherless Boa constrictors

    PubMed Central

    Booth, Warren; Johnson, Daniel H.; Moore, Sharon; Schal, Coby; Vargo, Edward L.

    2011-01-01

    Parthenogenesis in vertebrates is considered an evolutionary novelty. In snakes, all of which exhibit genetic sex determination with ZZ : ZW sex chromosomes, this rare form of asexual reproduction has failed to yield viable female WW offspring. Only through complex experimental manipulations have WW females been produced, and only in fish and amphibians. Through microsatellite DNA fingerprinting, we provide the first evidence of facultative parthenogenesis in a Boa constrictor, identifying multiple, viable, non-experimentally induced females for the first time in any vertebrate lineage. Although the elevated homozygosity of the offspring in relation to the mother suggests that the mechanism responsible may be terminal fusion automixis, no males were produced, potentially indicating maternal sex chromosome hemizygosity (WO). These findings provide the first evidence of parthenogenesis in the family Boidae (Boas), and suggest that WW females may be more common within basal reptilian lineages than previously assumed. PMID:21047849

  19. Bioethanol from poplar: a commercially viable alternative to fossil fuel in the European Union.

    PubMed

    Littlewood, Jade; Guo, Miao; Boerjan, Wout; Murphy, Richard J

    2014-01-01

    The European Union has made it a strategic objective to develop its biofuels market in order to minimize greenhouse gas (GHG) emissions, to help mitigate climate change and to address energy insecurity within the transport sector. Despite targets set at national and supranational levels, lignocellulosic bioethanol production has yet to be widely commercialized in the European Union. Here, we use techno-economic modeling to compare the price of bioethanol produced from short rotation coppice (SRC) poplar feedstocks under two leading processing technologies in five European countries. Our evaluation shows that the type of processing technology and varying national costs between countries results in a wide range of bioethanol production prices (€0.275 to 0.727/l). The lowest production prices for bioethanol were found in countries that had cheap feedstock costs and high prices for renewable electricity. Taxes and other costs had a significant influence on fuel prices at the petrol station, and therefore the presence and amount of government support for bioethanol was a major factor determining the competitiveness of bioethanol with conventional fuel. In a forward-looking scenario, genetically engineering poplar with a reduced lignin content showed potential to enhance the competitiveness of bioethanol with conventional fuel by reducing overall costs by approximately 41% in four out of the five countries modeled. However, the possible wider phenotypic traits of advanced poplars needs to be fully investigated to ensure that these do not unintentionally negate the cost savings indicated. Through these evaluations, we highlight the key bottlenecks within the bioethanol supply chain from the standpoint of various stakeholders. For producers, technologies that are best suited to the specific feedstock composition and national policies should be optimized. For policymakers, support schemes that benefit emerging bioethanol producers and allow renewable fuel to be

  20. Image Analysis via Soft Computing: Prototype Applications at NASA KSC and Product Commercialization

    NASA Technical Reports Server (NTRS)

    Dominguez, Jesus A.; Klinko, Steve

    2011-01-01

    This slide presentation reviews the use of "soft computing" which differs from "hard computing" in that it is more tolerant of imprecision, partial truth, uncertainty, and approximation and its use in image analysis. Soft computing provides flexible information processing to handle real life ambiguous situations and achieve tractability, robustness low solution cost, and a closer resemblance to human decision making. Several systems are or have been developed: Fuzzy Reasoning Edge Detection (FRED), Fuzzy Reasoning Adaptive Thresholding (FRAT), Image enhancement techniques, and visual/pattern recognition. These systems are compared with examples that show the effectiveness of each. NASA applications that are reviewed are: Real-Time (RT) Anomaly Detection, Real-Time (RT) Moving Debris Detection and the Columbia Investigation. The RT anomaly detection reviewed the case of a damaged cable for the emergency egress system. The use of these techniques is further illustrated in the Columbia investigation with the location and detection of Foam debris. There are several applications in commercial usage: image enhancement, human screening and privacy protection, visual inspection, 3D heart visualization, tumor detections and x ray image enhancement.

  1. Propulsion technology challenges for turn-of-the-century commercial aircraft

    NASA Technical Reports Server (NTRS)

    Ziemianski, Joseph A.; Ball, Calvin L.

    1993-01-01

    This paper highlights the efforts being performed or sponsored by NASA, in cooperation with the U.S. civil aviation industry, to address the propulsion system technological challenges that must be met in order to ensure a viable future for the industry. Both the subsonic and supersonic aeropropulsion programs are considered. Subsonic transport propulsion program elements, including ultra-high-bypass-ratio turbofans with attendant noise reduction efforts, high-efficiency cores, and combustor emissions reductions are discussed in terms of goals, technical issues, and problem solutions. Similarly, the high-speed research propulsion efforts addressing a high-speed commercial transport are reviewed in terms of environmental barrier issues, such as oxides of nitrogen and noise reduction, and the related economic issues.

  2. MBE development of dilute nitrides for commercial long-wavelength laser applications

    NASA Astrophysics Data System (ADS)

    Malis, O.; Liu, W. K.; Gmachl, C.; Fastenau, J. M.; Joel, A.; Gong, P.; Bland, S. W.; Moshegov, N.

    2003-04-01

    InGaAsN-based materials are being developed at IQE, Inc. for 1.3 μm laser applications. Both MBE and MOCVD growth technology are employed and under investigation for commercial viability. The MBE effort focuses on optimizing the process for the large-volume manufacturing environment. The PL efficiencies of InGaAsN QWs grown with different nitrogen sources on single and multi-wafer MBE platforms are compared. The effect of various annealing treatments on the PL intensity and wavelength uniformity is also discussed in detail. The PL intensity of MBE-grown InGaAsN QWs is inferior to the efficiency of MOCVD samples emitting below 1.29 μm. MOCVD samples, however, exhibit a faster decay of the PL intensity with increasing wavelength, and loose their advantage above 1.29 μm. Deep and shallow ridge-waveguide lasers emitting at 1.28 μm were processed from the MBE material and the laser characteristics are discussed.

  3. Commercial application of rainfall simulation

    NASA Astrophysics Data System (ADS)

    Loch, Rob J.

    2010-05-01

    Landloch Pty Ltd is a commercial consulting firm, providing advice on a range of land management issues to the mining and construction industries in Australia. As part of the company's day-to-day operations, rainfall simulation is used to assess material erodibility and to investigate a range of site attributes. (Landloch does carry out research projects, though such are not its core business.) When treated as an everyday working tool, several aspects of rainfall simulation practice are distinctively modified. Firstly, the equipment used is regularly maintained, and regularly upgraded with a primary focus on ease, safety, and efficiency of use and on reliability of function. As well, trained and experienced technical support is considered essential. Landloch's chief technician has over 10 years experience in running rainfall simulators at locations across Australia and in Africa and the Pacific. Secondly, the specific experimental conditions established for each set of rainfall simulator runs are carefully considered to ensure that they accurately represent the field conditions to which the data will be subsequently applied. Considerations here include: • wetting and drying cycles to ensure material consolidation and/or cementation if appropriate; • careful attention to water quality if dealing with clay soils or with amendments such as gypsum; • strong focus on ensuring that the erosion processes considered are those of greatest importance to the field situation of concern; and • detailed description of both material and plot properties, to increase the potential for data to be applicable to a wider range of projects and investigations. Other important company procedures include: • For each project, the scientist or engineer responsible for analysing and reporting rainfall simulator data is present during the running of all field plots, as it is essential that they be aware of any specific conditions that may have developed when the plots were subjected

  4. Commercial transport aircraft composite structures

    NASA Technical Reports Server (NTRS)

    Mccarty, J. E.

    1983-01-01

    The role that analysis plays in the development, production, and substantiation of aircraft structures is discussed. The types, elements, and applications of failure that are used and needed; the current application of analysis methods to commercial aircraft advanced composite structures, along with a projection of future needs; and some personal thoughts on analysis development goals and the elements of an approach to analysis development are discussed.

  5. Adaptation of commercial microscopes for advanced imaging applications

    NASA Astrophysics Data System (ADS)

    Brideau, Craig; Poon, Kelvin; Stys, Peter

    2015-03-01

    Today's commercially available microscopes offer a wide array of options to accommodate common imaging experiments. Occasionally, an experimental goal will require an unusual light source, filter, or even irregular sample that is not compatible with existing equipment. In these situations the ability to modify an existing microscopy platform with custom accessories can greatly extend its utility and allow for experiments not possible with stock equipment. Light source conditioning/manipulation such as polarization, beam diameter or even custom source filtering can easily be added with bulk components. Custom and after-market detectors can be added to external ports using optical construction hardware and adapters. This paper will present various examples of modifications carried out on commercial microscopes to address both atypical imaging modalities and research needs. Violet and near-ultraviolet source adaptation, custom detection filtering, and laser beam conditioning and control modifications will be demonstrated. The availability of basic `building block' parts will be discussed with respect to user safety, construction strategies, and ease of use.

  6. Space processing applications payload equipment study. Volume 2E: Commercial equipment utility

    NASA Technical Reports Server (NTRS)

    Smith, A. G. (Editor)

    1974-01-01

    Examination of commercial equipment technologies revealed that the functional performance requirements of space processing equipment could generally be met by state-of-the-art design practices. Thus, an apparatus could be evolved from a standard item or derived by custom design using present technologies. About 15 percent of the equipment needed has no analogous commercial base of derivation and requires special development. This equipment is involved primarily with contactless heating and position control. The derivation of payloads using commercial equipment sources provides a broad and potentially cost-effective base upon which to draw. The derivation of payload equipment from commercial technologies poses other issues beyond that of the identifiable functional performance, but preliminary results on testing of selected equipment testing appear quite favorable. During this phase of the SPA study, several aspects of commercial equipment utility were assessed and considered. These included safety, packaging and structural, power conditioning (electrical/electronic), thermal and materials of construction.

  7. Localized treatments using commercial dust and liquid formulations of fipronil against Coptotermes formosanus (Isoptera: Rhinotermitidae) in the laboratory.

    PubMed

    Gautam, Bal K; Henderson, Gregg; Wang, Cai

    2014-04-01

    Use of proper application methods and formulations of termiticides are important to reduce their negative impact to the environment. In this study, we conducted laboratory experiments to determine the effect of localized treatments with commercial dust and liquid formulations of fipronil against Formosan subterranean termites, Coptotermes formosanus Shiraki. The test arena consisted of a specially designed 16-chambered structure with a center chamber connected to 5 foraging chambers that themselves were connected to 10 additional foraging chambers. One peripheral chamber received a liquid or dust treatment and termites were released in the center chamber. Results showed that >91% of the termites were dead within the 9-d test period despite the localized treatment of only 1 foraging chamber. Termites that were still alive after 9 d were transferred to an untreated dish and held for 10 more days. The majority of those termites were dead and the rest were moribund on day 19. Regardless of the specific dish treated, both formulations of fipronil were found to be highly efficacious. Termites did not exhibit repellency to either formulation. Our results suggest that localized (or spot) treatment with either commercially available dust or liquid formulations of fipronil can be a viable option for control of a termite infestation where complete soil drenching is not desirable. © 2013 Institute of Zoology, Chinese Academy of Sciences.

  8. Determination of viable Salmonellae from potable and source water through PMA assisted qPCR.

    PubMed

    Singh, Gulshan; Vajpayee, Poornima; Bhatti, Saurabh; Ronnie, Nirmala; Shah, Nimish; McClure, Peter; Shanker, Rishi

    2013-07-01

    Resource constrained countries identified as endemic zones for pathogenicity of Salmonella bear an economic burden due to recurring expenditure on medical treatment. qPCR used for Salmonella detection could not discriminate between viable and nonviable cells. Propidium monoazide (PMA) that selectively penetrates nonviable cells to cross-link their DNA, was coupled with ttr gene specific qPCR for quantifying viable salmonellae in source/potable waters collected from a north Indian city. Source water (raw water for urban potable water supply) and urban potable water exhibited viable salmonellae in the range of 2.1×10(4)-2.6×10(6) and 2-7160CFU/100mL, respectively. Potable water at water works exhibited DNA from dead cells but no viable cells were detected. PMA assisted qPCR could specifically detect low numbers of live salmonellae in Source and potable waters. This strategy can be used in surveillance of urban potable water distribution networks to map contamination points for better microbial risk management. Copyright © 2013 Elsevier Inc. All rights reserved.

  9. NASA's approach to the commercial use of space

    NASA Technical Reports Server (NTRS)

    Gillam, I. T., IV

    1984-01-01

    NASA planning activities in the area of commercial development of space resources are reviewed. Examples of specific types of commercial space ventures are given, according to three different categories: new commercial high-technology ventures; new commercial application of existing space technology, and commercial ventures resulting from the transfer of existing space programs to the private sector. Basic objectives for reducing technical, financial and institutional risks for commercial space operations are considered. Attention is given to the cooperative working environment encouraged by Joint Endeavor Agreements (JEAs) and Technical Exchange Agreements (TEAs) between industrial organizations in the development of space systems. Benefits of the commercial development of space resources include the production of purer pharmaceuticals for the treatment of cancers, kidney diseases, and diabetes; and the development of ultra-pure semiconductor crystals for use in next generation electronic equipment.

  10. Commercial and Industrial Wiring.

    ERIC Educational Resources Information Center

    Kaltwasser, Stan; Flowers, Gary

    This module is the third in a series of three wiring publications, includes additional technical knowledge and applications required for job entry in the commercial and industrial wiring trade. The module contains 15 instructional units that cover the following topics: blueprint reading and load calculations; tools and equipment; service;…

  11. Separable Bilayer Microfiltration Device for Viable Label-free Enrichment of Circulating Tumour Cells

    NASA Astrophysics Data System (ADS)

    Zhou, Ming-Da; Hao, Sijie; Williams, Anthony J.; Harouaka, Ramdane A.; Schrand, Brett; Rawal, Siddarth; Ao, Zheng; Brennaman, Randall; Gilboa, Eli; Lu, Bo; Wang, Shuwen; Zhu, Jiyue; Datar, Ram; Cote, Richard; Tai, Yu-Chong; Zheng, Si-Yang

    2014-12-01

    The analysis of circulating tumour cells (CTCs) in cancer patients could provide important information for therapeutic management. Enrichment of viable CTCs could permit performance of functional analyses on CTCs to broaden understanding of metastatic disease. However, this has not been widely accomplished. Addressing this challenge, we present a separable bilayer (SB) microfilter for viable size-based CTC capture. Unlike other single-layer CTC microfilters, the precise gap between the two layers and the architecture of pore alignment result in drastic reduction in mechanical stress on CTCs, capturing them viably. Using multiple cancer cell lines spiked in healthy donor blood, the SB microfilter demonstrated high capture efficiency (78-83%), high retention of cell viability (71-74%), high tumour cell enrichment against leukocytes (1.7-2 × 103), and widespread ability to establish cultures post-capture (100% of cell lines tested). In a metastatic mouse model, SB microfilters successfully enriched viable mouse CTCs from 0.4-0.6 mL whole mouse blood samples and established in vitro cultures for further genetic and functional analysis. Our preliminary studies reflect the efficacy of the SB microfilter device to efficiently and reliably enrich viable CTCs in animal model studies, constituting an exciting technology for new insights in cancer research.

  12. Accelerating the commercialization of university technologies for military healthcare applications: the role of the proof of concept process

    NASA Astrophysics Data System (ADS)

    Ochoa, Rosibel; DeLong, Hal; Kenyon, Jessica; Wilson, Eli

    2011-06-01

    The von Liebig Center for Entrepreneurism and Technology Advancement at UC San Diego (vonliebig.ucsd.edu) is focused on accelerating technology transfer and commercialization through programs and education on entrepreneurism. Technology Acceleration Projects (TAPs) that offer pre-venture grants and extensive mentoring on technology commercialization are a key component of its model which has been developed over the past ten years with the support of a grant from the von Liebig Foundation. In 2010, the von Liebig Entrepreneurism Center partnered with the U.S. Army Telemedicine and Advanced Technology Research Center (TATRC), to develop a regional model of Technology Acceleration Program initially focused on military research to be deployed across the nation to increase awareness of military medical needs and to accelerate the commercialization of novel technologies to treat the patient. Participants to these challenges are multi-disciplinary teams of graduate students and faculty in engineering, medicine and business representing universities and research institutes in a region, selected via a competitive process, who receive commercialization assistance and funding grants to support translation of their research discoveries into products or services. To validate this model, a pilot program focused on commercialization of wireless healthcare technologies targeting campuses in Southern California has been conducted with the additional support of Qualcomm, Inc. Three projects representing three different universities in Southern California were selected out of forty five applications from ten different universities and research institutes. Over the next twelve months, these teams will conduct proof of concept studies, technology development and preliminary market research to determine the commercial feasibility of their technologies. This first regional program will help build the needed tools and processes to adapt and replicate this model across other regions in the

  13. A new application of a sodium deoxycholate-propidium monoazide-quantitative PCR assay for rapid and sensitive detection of viable Cronobacter sakazakii in powdered infant formula.

    PubMed

    Zhou, Baoqing; Chen, Bolu; Wu, Xin; Li, Fan; Yu, Pei; Aguilar, Zoraida P; Wei, Hua; Xu, Hengyi

    2016-12-01

    A rapid, reliable, and sensitive method for the detection of Cronobacter sakazakii, a common foodborne pathogen that may cause serious neonatal disease, has been developed. In this study, a rapid real-time quantitative PCR (qPCR) assay combined with sodium deoxycholate (SD) and propidium monoazide (PMA) was developed to detect C. sakazakii contamination in powdered infant formula (PIF). This method could eliminate the interference from dead or injured bacteria. Optimization studies indicated that SD and PMA at 0.08% (wt/vol) and 5µg/mL, respectively, were the most appropriate. In addition, qPCR, PMA-qPCR, SD-PMA-qPCR, and plate count assays were used to account for the number of viable bacteria in cell suspensions that were exposed to a 55°C water bath at different length of time. As a result, the viable number by PMA-qPCR showed significantly higher than of the number from SD-PMA-qPCR or plate counts. The number of viable bacteria was consistent between SD-PMA-qPCR and traditional plate counts, which indicated that SD treatment could eliminate the interference from dead or injured cells. Using the optimized parameters, the limit of detection with the SD-PMA-qPCR assay was 3.3×10 2 cfu/mL and 4.4×10 2 cfu/g in pure culture and in spiked PIF, respectively. A similar detection limit of 5.6×10 2 cfu/g was obtained in the presence of the Staphylococcus aureus (10 7 cfu/mL). The combined SD-PMA-qPCR assay holds promise for the rapid detection of viable C. sakazakii in PIF. Copyright © 2016 American Dairy Science Association. Published by Elsevier Inc. All rights reserved.

  14. Commercial nickel-metal hydride (Ni-MH) technology evaluation

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Erbacher, J.K.; Vukson, S.P.

    1997-12-01

    Available cylindrical and prismatic commercial Ni-MH batteries using AB{sub 5} and AB{sub 2} cathodes were evaluated for possible application to military aircraft batteries. Commercial AB{sub 5} technology is further advanced than AB{sub 2} technology and would require less alloy, electrolyte and single cell/battery development for near term (3--5 years) applications. Tested AB{sub 2} technology appears inadequate to meet the near term military requirements and would require a major development in the alloy to overcome the irreversible capacity loss at temperatures above 49 C.

  15. Storage mite contamination of commercial dry dog food in south-eastern Australia.

    PubMed

    Hibberson, C E; Vogelnest, L J

    2014-06-01

    To evaluate contamination of unopened and opened stored sources of commercial dry dog food by viable storage mites. Prospective laboratory and field study. Samples were collected from nine brands of previously unopened bags (new bags) of dry food and 20 field sources of stored dry food in homes in Sydney and Canberra, Australia. All samples were initially examined for the presence of mites using a stereo-binocular microscope and then placed in separate filter-paper-sealed containers. Field samples were incubated at an average temperature of 29°C and 78% relative humidity (RH) for 5 weeks and then at average 26°C/83% RH for 8 weeks. Paired new-bag samples were stored under room conditions (average 23°C/47% RH) and controlled incubator conditions (average 26°C/80% RH) for 6 weeks. All samples were thoroughly examined for mites, mite eggs and visible mould once weekly using a stereo-binocular microscope. Storage mites were not visualised in any of the field samples or in new-bag samples stored at room temperature. Storage mites, identified as Tyrophagus putrescentiae, were visualised in increasing numbers in seven of nine new-bag samples after incubation, with first mites and then eggs evident after 3 weeks of incubation. We confirmed the presence of viable storage mites in a range of previously unopened commercial dry dog foods in Australia and confirmed the possibility of heavy storage mite contamination for dry food stored under conditions of moderate temperature and high humidity. These findings have relevance to storage mite and/or dust mite sensitivity in canine atopic dermatitis. © 2014 Australian Veterinary Association.

  16. NASA's human system risk management approach and its applicability to commercial spaceflight.

    PubMed

    Law, Jennifer; Mathers, Charles H; Fondy, Susan R E; Vanderploeg, James M; Kerstman, Eric L

    2013-01-01

    As planning continues for commercial spaceflight, attention is turned to NASA to assess whether its human system risk management approach can be applied to mitigate the risks associated with commercial suborbital and orbital flights. NASA uses a variety of methods to assess the risks to the human system based on their likelihood and consequences. In this article, we review these methods and categorize the risks in the system as "definite," "possible," or "least" concern for commercial spaceflight. As with career astronauts, these risks will be primarily mitigated by screening and environmental control. Despite its focus on long-duration exploration missions, NASA's human system risk management approach can serve as a preliminary knowledge base to help medical planners prepare for commercial spaceflights.

  17. Evaluation of Commercial Agrochemicals as New Tools for Malaria Vector Control.

    PubMed

    Hoppé, Mark; Hueter, Ottmar F; Bywater, Andy; Wege, Philip; Maienfisch, Peter

    2016-10-01

    Malaria is a vector-borne and life-threatening disease caused by parasites that are transmitted to people through the bites of infected female Anopheles mosquitoes. The vector control insecticide market represents a small fraction of the crop protection market and is estimated to be valued at up to $500 million at the active ingredient level. Insecticide resistance towards the current WHOPES-approved products urgently requires the development of new tools to protect communities against the transmission of malaria. The evaluation of commercial products for malaria vector control is a viable and cost effective strategy to identify new malaria vector control products. Several examples of such spin-offs from crop protection insecticides are already evidencing the success of this strategy, namely pirimiphos-methyl for indoor residual sprays and spinosad, diflubenzuron, novaluron, and pyriproxifen for mosquito larvae control, a supplementary technology for control of malaria vectors. In our study the adulticidal activities of 81 insecticides representing 23 insecticidal modes of action classes, 34 fungicides from 6 fungicidal mode of action classes and 15 herbicides from 2 herbicidal modes of action classes were tested in a newly developed screening system. WHOPES approved insecticides for malaria vector control consistently caused 80-100% mortality of adult Anopheles stephensi at application rates between 0.2 and 20 mg active ingradient (AI) litre -1 . Chlorfenapyr, fipronil, carbosulfan and endosulfan showed the expected good activity. Four new insecticides and three fungicides with promising activity against adult mosquitoes were identified, namely the insecticides acetamiprid, thiamethoxam, thiocyclam and metaflumizone and the fungicides diflumetorin, picoxystrobin, and fluazinam. Some of these compounds certainly deserve to be further evaluated for malaria vector control. This is the first report describing good activity of commercial fungicides against malaria

  18. 46 CFR 105.05-1 - Commercial fishing vessels dispensing petroleum products.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 46 Shipping 4 2012-10-01 2012-10-01 false Commercial fishing vessels dispensing petroleum products... MISCELLANEOUS VESSELS COMMERCIAL FISHING VESSELS DISPENSING PETROLEUM PRODUCTS Application § 105.05-1 Commercial fishing vessels dispensing petroleum products. (a) The provisions of this part, with the exception of...

  19. 46 CFR 105.05-1 - Commercial fishing vessels dispensing petroleum products.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 46 Shipping 4 2014-10-01 2014-10-01 false Commercial fishing vessels dispensing petroleum products... MISCELLANEOUS VESSELS COMMERCIAL FISHING VESSELS DISPENSING PETROLEUM PRODUCTS Application § 105.05-1 Commercial fishing vessels dispensing petroleum products. (a) The provisions of this part, with the exception of...

  20. 46 CFR 105.05-1 - Commercial fishing vessels dispensing petroleum products.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 46 Shipping 4 2013-10-01 2013-10-01 false Commercial fishing vessels dispensing petroleum products... MISCELLANEOUS VESSELS COMMERCIAL FISHING VESSELS DISPENSING PETROLEUM PRODUCTS Application § 105.05-1 Commercial fishing vessels dispensing petroleum products. (a) The provisions of this part, with the exception of...

  1. Relating a Jet-Surface Interaction Experiment to a Commercial Supersonic Transport Aircraft Using Numerical Simulations

    NASA Technical Reports Server (NTRS)

    Dippold, Vance F., III; Friedlander, David

    2017-01-01

    NASA and industry partners desire to reintroduce commercial supersonic airliners to the air transportation system. There are a number of technical challenges that must be overcome by future commercial supersonic airliners to make them viable solutions in society. NASA is specifically concerned with the challenges of reducing boom during supersonic cruise, maximizing range, and reducing airport community noise to acceptable levels. Concepts for commercial supersonic transports, such as the concept aircraft by Lockheed Martin pictured in Figure 1, place the engine nozzles in close proximity to wing and tail surfaces. However, the effects of noise shielding and noise radiation are not fully understood for installed propulsion systems. A series of acoustic tests were conducted on the NASA Glenn Research Centers Nozzle Acoustic Test Rig (NATR) to address the challenge of reducing airport community noise, which is often dominated by jet noise. To best represent the conceptual aircraft in the acoustic tests, noise measurements were taken of the jet in close proximity of simulated aerodynamic surfaces, not simply of an isolated jet.

  2. Prototype rigid polyimide components. [application of Apollo technology to commercial nonflammable materials

    NASA Technical Reports Server (NTRS)

    Wykes, D. H.

    1975-01-01

    The activity is reported which was conducted for utilizing spin-off Apollo base technology to fabricate a variety of commercial and aerospace related parts that are nonflammable and resistant to high-temperature degradation. Manufacturing techniques and the tooling used to fabricate each of the polyimide/glass structures is discussed. A brief history, tracing the development of high-temperature polyimide resins, is presented along with a discussion of the properties of DuPont's PI 2501/glass material (later redesignated PI 4701/glass). Mechanical and flammability properties of DuPont's PI 2501/glass laminates are compared with epoxy, phenolic, and silicone high-temperature resin/glass material systems. Offgassing characteristics are also presented. A discussion is included of the current developments in polyimide materials technology and the potential civilian and government applications of polyimide materials to reduce fire hazards and increase the survivability of men and equipment.

  3. Business analysis: The commercial mission of the International Asteroid Mission

    NASA Astrophysics Data System (ADS)

    The mission of the International Asteroid Mission (IAM) is providing asteroidal resources to support activities in space. The short term goal is to initiate IAM by mining a near-Earth, hydrous carbonaceous chondrite asteroid to service the nearer-term market of providing cryogenic rocket fuel in low lunar orbit (LLO). The IAM will develop and contract for the building of the transportation vehicles and equipment necessary for this undertaking. The long-term goal is to expand operations by exploiting asteroids in other manners, as these options become commercially viable. The primary business issues are what revenue can be generated from the baseline mission, how much will the mission cost, and how funding for this mission can be raised. These issues are addressed.

  4. U.S. commercial space policies - Implications for developing countries

    NASA Technical Reports Server (NTRS)

    Gillam, Isaac T., IV; Stone, Barbara A.

    1987-01-01

    Recent U.S. policy developments on the commercial use of space are summarized and their international implications are considered. Attention is given to successful applications of technology developed in space, including an implantable cancer medication system, an implantable defibrillator, an ultrasonic residual stress monitor, and aquaculture treatment techniques. NASA projects involving bioengineering and rehabilitation applications are summarized, and plans to investigate high-temperature superconductors in space are addressed. Recent agreements entred into by NASA for space commercial studies are reviewed.

  5. Early high-Tc commercial activity

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Not Available

    1988-01-01

    The high temperature superconductors have already begun to generate the first stirrings of commercial activity. Companies that supply instruments and chemicals to researchers have enjoyed increased business. At least one company has begun to supply educational materials. Venture capital firms have invested about $15 million in startups to capitalize on developments in high-field applications, superconducting electronics, and magnetic shielding. Consulting firms are gathering and selling market research information. And the federal government is studying the question of how to cooperate with American companies to commercialize the research taking place in the national laboratories. This article discusses these issues.

  6. Private Astronaut Training Prepares Commercial Crews of Tomorrow

    NASA Technical Reports Server (NTRS)

    2015-01-01

    A new company that includes a handful of former NASA personnel is already taking applications for the first comprehensive commercial astronaut training approved by the Federal Aviation Administration. Waypoint 2 Space, located at Johnson Space Center, hopes to draw space tourists and enthusiasts and future commercial crewmembers with first-hand NASA know-how, as well as agency training technology.

  7. Pesticide Applicator Training Manual, Category 8A: General Public Health Pest Control for New Jersey. A Training Program for the Certification of Commercial Pesticide Applicators, and Study Questions.

    ERIC Educational Resources Information Center

    Schulze, Terry L.; Kriner, Ray R.

    This training manual provides information needed to meet the minimum EPA standards for certification as a commercial applicator of pesticides in the public health pest control category. The text discusses invertebrate pests such as cockroaches, lice, fleas, and mites, vertebrate pests; and plant pests such as poison ivy and ragweed. A study guide…

  8. Commercializing solar for industry in California

    NASA Astrophysics Data System (ADS)

    Yudelson, J.

    1980-10-01

    The State of California has begun a commercialization program for increasing the rate of solar applications in industry. The components of this program include low interest loans, tax credits, revenue bonds and educational efforts. Many California industries appear to be likely candidates for solar systems, but as yet only a few companies have elected to install them. The various barriers to solar use by industry are primarily perceptual and financial. The emphasis of the state program for commercialization is turning increasingly towards educational seminars for industry groups and development of creative financial tools and arrangements. There are a few remaining legislative changes at state and federal levels, primarily involving leasing and tax laws which, if enacted, would overcome all of the remaining financial barriers to widespread adoption of solar applications by industry.

  9. Surrogate Joint Aerial Layer Network (JALN) Experiment: Applications of Commercial-Off-The-Shelf Technologies for Researching Future JALN Challenges

    DTIC Science & Technology

    2014-12-01

    CHALLENGES DECEMBER 2014 TECHNICAL REPORT APPROVED FOR PUBLIC RELEASE; DISTRIBUTION UNLIMITED STINFO COPY AIR FORCE RESEARCH LABORATORY INFORMATION...JOINT AERIAL LAYER NETWORK (JALN) EXPERIMENT: APPLICATION OF COMMERCIAL-OFF-THE-SHELF TECHNOLOGIES FOR RESEARCHING FUTURE JALN CHALLENGES 5a... challenge JALN developers. The use of low-cost COTS wireless technology is found to be a suitable surrogate for military hardware for investigating

  10. Civil tiltrotor missions and applications. Phase 2: The commercial passenger market

    NASA Technical Reports Server (NTRS)

    Thompson, P.; Neir, R.; Reber, R.; Scholes, R.; Alexander, H.; Sweet, D.; Berry, D. (Editor)

    1991-01-01

    The commercial passenger market for the civil tiltrotor was examined in phase 2. A market responsive commercial tiltrotor was found to be technically feasible, and a significant worldwide market potential was found to exist for such an aircraft, especially for relieving congestion in urban area-to-urban area service and for providing cost effective hub airport feeder service. Potential technical obstacles of community noise, vertiport area navigation, surveillance, and control, and the pilot/aircraft interface were determined to be surmountable. Nontechnical obstacles relating to national commitment and leadership and development of ground and air infrastructure were determined to be more difficult to resolve; an innovative public/private partnership is suggested to allow coordinated development of an initial commercial tiltrotor network to relieve congestion in the crowded US Northeast corridor by the year 2000.

  11. Hybrid Environmental Control System Integrated Modeling Trade Study Analysis for Commercial Aviation

    NASA Astrophysics Data System (ADS)

    Parrilla, Javier

    Current industry trends demonstrate aircraft electrification will be part of future platforms in order to achieve higher levels of efficiency in various vehicle level sub-systems. However electrification requires a substantial change in aircraft design that is not suitable for re-winged or re-engined applications as some aircraft manufacturers are opting for today. Thermal limits arise as engine cores progressively get smaller and hotter to improve overall engine efficiency, while legacy systems still demand a substantial amount of pneumatic, hydraulic and electric power extraction. The environmental control system (ECS) provides pressurization, ventilation and air conditioning in commercial aircraft, making it the main heat sink for all aircraft loads with exception of the engine. To mitigate the architecture thermal limits in an efficient manner, the form in which the ECS interacts with the engine will have to be enhanced as to reduce the overall energy consumed and achieve an energy optimized solution. This study examines a tradeoff analysis of an electric ECS by use of a fully integrated Numerical Propulsion Simulation System (NPSS) model that is capable of studying the interaction between the ECS and the engine cycle deck. It was found that a peak solution lays in a hybrid ECS where it utilizes the correct balance between a traditional pneumatic and a fully electric system. This intermediate architecture offers a substantial improvement in aircraft fuel consumptions due to a reduced amount of waste heat and customer bleed in exchange for partial electrification of the air-conditions pack which is a viable option for re-winged applications.

  12. This idea worth anything? Mechanics of technology transfer.

    PubMed

    Goodson, J Max

    2006-01-01

    The path from a proven scientific idea to a commercially viable product is seldom easy. It often requires ten or more years and millions of dollars. The essential elements include a creative concept that has been proven sound, identification of the commercial applicability of the concept, and financing and management of the development process.

  13. A METHOD TO DETECT VIABLE HELICOBACTER PYLORI BACTERIA IN GROUNDWATER

    EPA Science Inventory

    The inability to detect the presence of viable Helicobacter pylori bacteria in environmental waters has hindered the public health community in assessing the role water may playin the transmission of this pathogen. This work describes a cultural enrichment method coupled with an...

  14. University of Utah, Energy Commercialization Center

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Thompson, James

    During the Energy Commercialization Center’s (ECC) three years in operation, the only thing constant was change. The world of commercialization and cleantech evolved significantly during the time the ECC was formed and operating, including: the availability of cleantech funding lessoned, the growth of incubators and accelerators skyrocketed, the State of Utah created an office dedicated to energy development, the University of Utah was both praised and criticized for its success in commercialization, and the Federal government temporarily shut down. During the three-year grant there were three principle investigators on the grant, as well as three directors for the University’s Commercializationmore » Office. Change can be hard for an organization,but as we instruct the companies we support, “Fail fast and fail often, because it is the fastest path to success.” Although there were some unanticipated challenges along the way, the local ecosystem is stronger because of the ECC’s efforts. Perhaps the greatest lesson learned was the importance of aligned incentives between key stakeholders in the commercialization process and the need for resources at the company and individual entrepreneur levels. The universities have systems and incentives to commercialize technologies, but creating value and companies generally rest with the individuals and entrepreneurs. Unfortunately the ECC was unable to create a viable mechanism to transfer the commercialization process that successfully aligned incentives and achieve a more effective ecosystem within the Rocky Mountain West. However, the ECC was successful in adding value to the individual ecosystems, and connecting national resources to regional and local needs. Regarding the ECC’s effectiveness in developing a cleantech commercialization ecosystem, initial inroads and relationships were established with key stakeholders. However, incentives, perceived or real competition, differences in commercialization

  15. Detection of viable but non-culturable Escherichia coli O157:H7 by PCR in combination with propidium monoazide.

    PubMed

    Zhong, Junliang; Zhao, Xihong

    2018-01-01

    The aim of this study was to evaluate the applicability of the conventional PCR detection method combined with propidium monoazide (PMA) treatment for the detection of viable but non-culturable (VBNC) state Escherichia coli O157:H7 in ground beef meatballs. Under low temperature, E. coli O157:H7 cells were induced into the VBNC state in ground beef meatballs at - 20 °C after 152 days. The optimal PMA concentration of 5 µg/mL was obtained in beef meatball samples, which could completely inhibit the DNA amplification on dead cells (10 6  cells/mL) but with no inhibition on viable cells. The established PMA-PCR assay revealed that the VBNC counts exceeded 10 7  CFU/mL in artificial contamination beef samples, which could be used for semi-quantitative detection of VBNC cells in beef meatball samples. This study indicated that the PMA-PCR assay might be a potential method for detection of VBNC state E . coli O157:H7 cells in food products.

  16. 48 CFR 12.103 - Commercially available off-the-shelf (COTS) items.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... ACQUISITION REGULATION ACQUISITION PLANNING ACQUISITION OF COMMERCIAL ITEMS Acquisition of Commercial Items... indicated otherwise, all of the policies that apply to commercial items also apply to COTS. Section 12.505 lists the laws that are not applicable to COTS (in addition to 12.503 and 12.504); the components test...

  17. A viable logarithmic f(R) model for inflation

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Amin, M.; Khalil, S.; Salah, M.

    2016-08-18

    Inflation in the framework of f(R) modified gravity is revisited. We study the conditions that f(R) should satisfy in order to lead to a viable inflationary model in the original form and in the Einstein frame. Based on these criteria we propose a new logarithmic model as a potential candidate for f(R) theories aiming to describe inflation consistent with observations from Planck satellite (2015). The model predicts scalar spectral index 0.9615

  18. Benchmarking Commercial Conformer Ensemble Generators.

    PubMed

    Friedrich, Nils-Ole; de Bruyn Kops, Christina; Flachsenberg, Florian; Sommer, Kai; Rarey, Matthias; Kirchmair, Johannes

    2017-11-27

    We assess and compare the performance of eight commercial conformer ensemble generators (ConfGen, ConfGenX, cxcalc, iCon, MOE LowModeMD, MOE Stochastic, MOE Conformation Import, and OMEGA) and one leading free algorithm, the distance geometry algorithm implemented in RDKit. The comparative study is based on a new version of the Platinum Diverse Dataset, a high-quality benchmarking dataset of 2859 protein-bound ligand conformations extracted from the PDB. Differences in the performance of commercial algorithms are much smaller than those observed for free algorithms in our previous study (J. Chem. Inf. 2017, 57, 529-539). For commercial algorithms, the median minimum root-mean-square deviations measured between protein-bound ligand conformations and ensembles of a maximum of 250 conformers are between 0.46 and 0.61 Å. Commercial conformer ensemble generators are characterized by their high robustness, with at least 99% of all input molecules successfully processed and few or even no substantial geometrical errors detectable in their output conformations. The RDKit distance geometry algorithm (with minimization enabled) appears to be a good free alternative since its performance is comparable to that of the midranked commercial algorithms. Based on a statistical analysis, we elaborate on which algorithms to use and how to parametrize them for best performance in different application scenarios.

  19. Weldability, machinability and surfacing of commercial duplex stainless steel AISI2205 for marine applications - A recent review.

    PubMed

    Vinoth Jebaraj, A; Ajaykumar, L; Deepak, C R; Aditya, K V V

    2017-05-01

    In the present review, attempts have been made to analyze the metallurgical, mechanical, and corrosion properties of commercial marine alloy duplex stainless steel AISI 2205 with special reference to its weldability, machinability, and surfacing. In the first part, effects of various fusion and solid-state welding processes on joining DSS 2205 with similar and dissimilar metals are addressed. Microstructural changes during the weld cooling cycle such as austenite reformation, partitioning of alloying elements, HAZ transformations, and the intermetallic precipitations are analyzed and compared with the different welding techniques. In the second part, machinability of DSS 2205 is compared with the commercial ASS grades in order to justify the quality of machining. In the third part, the importance of surface quality in a marine exposure is emphasized and the enhancement of surface properties through peening techniques is highlighted. The research gaps and inferences highlighted in this review will be more useful for the fabrications involved in the marine applications.

  20. Small capacity, low cost (Ni-H2) design concept for commercial, military, and higher-volume aerospace applications

    NASA Technical Reports Server (NTRS)

    Wheeler, James R.; Cook, William D.; Smith, Ron

    1991-01-01

    Nickel Hydrogen (Ni/H2) batteries have become the technology of choice for both commercial and defense related satellites in geosynchronous orbits. Their use for low earth orbit (LEO) applications is not as advanced, but seems just as inevitable because of their inherent advantages over nickel cadmium batteries. These include superior energy density, longer cycle life, and better tolerance to over-charge and reversal. Ni/H2 cells have the added advantage in both construction and operation of not presenting the environmental possibility of cadmium pollution. Unfortunately, but necessarily, the design of these cells has been driven to high cost by the sophistication of the satellites and their uses. Now, using most of the same concepts but less costly materials and techniques, a low cost, small cell design was developed. Combined with the concept of the common pressure vessel, this new design promises to be ideal for the small-sat and commercial markets which, increasingly, are calling for large numbers of less expensive satellites.

  1. On-chip PMA labeling of foodborne pathogenic bacteria for viable qPCR and qLAMP detection

    USDA-ARS?s Scientific Manuscript database

    Propidium monoazide (PMA) is a membrane impermeable molecule that covalently bonds to double stranded DNA when exposed to light and inhibits the polymerase activity, thus enabling DNA amplification detection protocols that discriminate between viable and non-viable entities. Here, we present a micro...

  2. Surface and Electrical Characterization of Ag/AgCl Pseudo-Reference Electrodes Manufactured with Commercially Available PCB Technologies

    PubMed Central

    Moschou, Despina; Trantidou, Tatiana; Regoutz, Anna; Carta, Daniela; Morgan, Hywel; Prodromakis, Themistoklis

    2015-01-01

    Lab-on-Chip is a technology that could potentially revolutionize medical Point-of-Care diagnostics. Considerable research effort is focused towards innovating production technologies that will make commercial upscaling financially viable. Printed circuit board manufacturing techniques offer several prospects in this field. Here, we present a novel approach to manufacturing Printed Circuit Board (PCB)-based Ag/AgCl reference electrodes, an essential component of biosensors. Our prototypes were characterized both structurally and electrically. Scanning Electron Microscopy (SEM) and X-Ray Photoelectron Spectroscopy (XPS) were employed to evaluate the electrode surface characteristics. Electrical characterization was performed to determine stability and pH dependency. Finally, we demonstrate utilization along with PCB pH sensors, as a step towards a fully integrated PCB platform, comparing performance with discrete commercial reference electrodes. PMID:26213940

  3. Enumeration of Vibrio cholerae O1 in Bangladesh waters by fluorescent-antibody direct viable count.

    PubMed Central

    Brayton, P R; Tamplin, M L; Huq, A; Colwell, R R

    1987-01-01

    A field trial to enumerate Vibrio cholerae O1 in aquatic environments in Bangladesh was conducted, comparing fluorescent-antibody direct viable count with culture detection by the most-probable-number index. Specificity of a monoclonal antibody prepared against the O1 antigen was assessed and incorporated into the fluorescence staining method. All pond and water samples yielded higher counts of viable V. cholerae O1 by fluorescent-antibody direct viable count than by the most-probable-number index. Fluorescence microscopy is a more sensitive detection system than culture methods because it allows the enumeration of both culturable and nonculturable cells and therefore provides more precise monitoring of microbiological water quality. PMID:3324967

  4. Biosensor commercialization strategy - a theoretical approach.

    PubMed

    Lin, Chin-Tsai; Wang, Su-Man

    2005-01-01

    Biosensors are analytical devices, which use biological interactions to provide either qualitative or quantitative results. They are extensively employed in many fields such as clinical diagnosis and biomedicine, military applications, anti-terrorism, farm, garden and veterinary analysis, process control, fermentation control and analysis, pharmaceutical and drug analysis, food and drink production and analysis, pollution control and monitoring, microbiology, bacterial and viral analysis, mining, and industrial and toxic gases. The biosensor market has significantly increased and will be mushrooming in the next decade. The total biosensor market is estimated to be 10.8 billion dollars by 2007. The emerging biosensor market presents both opportunities and obstacles to start-up biosensor entrepreneurs. The major challenge and threat for these entrepreneurs is how to predict the biosensor market and how to convert promising biosensor technology into commercialized biosensors. By adopting a simple commercialization strategy framework, we identify two key elements of biosensor commercialization strategy: excludability and complementary asset. We further divide biosensor commercialization environments into four distinct sub-environments: the Attacker's Advantage, Reputation-Based Idea Trading, Greenfield Competition and Ideas Factories. This paper explains how the interaction between these two key elements shapes biosensor commercialization strategy and biosensor industry dynamics. This paper also discusses alternative commercialization strategies for each specific commercialization environment and how to choose from these alternatives. The analysis of this study further provides a good reference for start-up biosensor entrepreneurs to formulate effective biosensor commercialization strategy.

  5. Note: Commercial SQUID magnetometer-compatible NMR probe and its application for studying a quantum magnet.

    PubMed

    Vennemann, T; Jeong, M; Yoon, D; Magrez, A; Berger, H; Yang, L; Živković, I; Babkevich, P; Rønnow, H M

    2018-04-01

    We present a compact nuclear magnetic resonance (NMR) probe which is compatible with a magnet of a commercial superconducting quantum interference device magnetometer and demonstrate its application to the study of a quantum magnet. We employ trimmer chip capacitors to construct an NMR tank circuit for low temperature measurements. Using a magnetic insulator MoOPO 4 with S = 1/2 (Mo 5+ ) as an example, we show that the T-dependence of the circuit is weak enough to allow the ligand-ion NMR study of magnetic systems. Our 31 P NMR results are compatible with previous bulk susceptibility and neutron scattering experiments and furthermore reveal unconventional spin dynamics.

  6. Tools and Data Services from the NASA Earth Satellite Observations for Remote Sensing Commercial Applications

    NASA Technical Reports Server (NTRS)

    Vicente, Gilberto

    2005-01-01

    Several commercial applications of remote sensing data, such as water resources management, environmental monitoring, climate prediction, agriculture, forestry, preparation for and migration of extreme weather events, require access to vast amounts of archived high quality data, software tools and services for data manipulation and information extraction. These on the other hand require gaining detailed understanding of the data's internal structure and physical implementation of data reduction, combination and data product production. The time-consuming task must be undertaken before the core investigation can begin and is an especially difficult challenge when science objectives require users to deal with large multi-sensor data sets of different formats, structures, and resolutions.

  7. Note: Commercial SQUID magnetometer-compatible NMR probe and its application for studying a quantum magnet

    NASA Astrophysics Data System (ADS)

    Vennemann, T.; Jeong, M.; Yoon, D.; Magrez, A.; Berger, H.; Yang, L.; Živković, I.; Babkevich, P.; Rønnow, H. M.

    2018-04-01

    We present a compact nuclear magnetic resonance (NMR) probe which is compatible with a magnet of a commercial superconducting quantum interference device magnetometer and demonstrate its application to the study of a quantum magnet. We employ trimmer chip capacitors to construct an NMR tank circuit for low temperature measurements. Using a magnetic insulator MoOPO4 with S = 1/2 (Mo5+) as an example, we show that the T-dependence of the circuit is weak enough to allow the ligand-ion NMR study of magnetic systems. Our 31P NMR results are compatible with previous bulk susceptibility and neutron scattering experiments and furthermore reveal unconventional spin dynamics.

  8. New Earth Observation Capabilities For The Commercial Sector

    NASA Technical Reports Server (NTRS)

    Stefanov, William L.

    2017-01-01

    Earth observation data collected from orbital remote sensing systems are becoming increasingly critical to the short- and long-term operations of many commercial industries including agriculture, energy exploration, environmental management, transportation, and urban planning and operations. In this panel, I will present an overview of current and planned NASA remote sensing systems for Earth observation with relevance to commercial and industrial applications. Special emphasis will be given to the International Space Station (ISS) as a platform for both commercial technology demonstration/development and operational data collection through the ISS National Laboratory.

  9. Microfabricated Hydrogen Sensor Technology for Aerospace and Commercial Applications

    NASA Technical Reports Server (NTRS)

    Hunter, Gary W.; Bickford, R. L.; Jansa, E. D.; Makel, D. B.; Liu, C. C.; Wu, Q. H.; Powers, W. T.

    1994-01-01

    Leaks on the Space Shuttle while on the Launch Pad have generated interest in hydrogen leak monitoring technology. An effective leak monitoring system requires reliable hydrogen sensors, hardware, and software to monitor the sensors. The system should process the sensor outputs and provide real-time leak monitoring information to the operator. This paper discusses the progress in developing such a complete leak monitoring system. Advanced microfabricated hydrogen sensors are being fabricated at Case Western Reserve University (CWRU) and tested at NASA Lewis Research Center (LeRC) and Gencorp Aerojet (Aerojet). Changes in the hydrogen concentrations are detected using a PdAg on silicon Schottky diode structure. Sensor temperature control is achieved with a temperature sensor and heater fabricated onto the sensor chip. Results of the characterization of these sensors are presented. These sensors can detect low concentrations of hydrogen in inert environments with high sensitivity and quick response time. Aerojet is developing the hardware and software for a multipoint leak monitoring system designed to provide leak source and magnitude information in real time. The monitoring system processes data from the hydrogen sensors and presents the operator with a visual indication of the leak location and magnitude. Work has commenced on integrating the NASA LeRC-CWRU hydrogen sensors with the Aerojet designed monitoring system. Although the leak monitoring system was designed for hydrogen propulsion systems, the possible applications of this monitoring system are wide ranged. Possible commercialization of the system will also be discussed.

  10. Commercial Capaciflector

    NASA Technical Reports Server (NTRS)

    Vranish, John M.

    1991-01-01

    A capacitive proximity/tactile sensor with unique performance capabilities ('capaciflector' or capacitive reflector) is being developed by NASA/Goddard Space Flight Center (GSFC) for use on robots and payloads in space in the interests of safety, efficiency, and ease of operation. Specifically, this sensor will permit robots and their attached payloads to avoid collisions in space with humans and other objects and to dock these payloads in a cluttered environment. The sensor is simple, robust, and inexpensive to manufacture with obvious and recognized commercial possibilities. Accordingly, NASA/GSFC, in conjunction with industry, is embarking on an effort to 'spin' this technology off into the private sector. This effort includes prototypes aimed at commercial applications. The principles of operation of these prototypes are described along with hardware, software, modelling, and test results. The hardware description includes both the physical sensor in terms of a flexible printed circuit board and the electronic circuitry. The software description will include filtering and detection techniques. The modelling will involve finite element electric field analysis and will underline techniques used for design optimization.

  11. Assessment of the potential suitability of selected commercially available enzymes for cleaning-in-place (CIP) in the dairy industry.

    PubMed

    Boyce, Angela; Piterina, Anna V; Walsh, Gary

    2010-10-01

    The potential suitability of 10 commercial protease and lipase products for cleaning-in-place (CIP) application in the dairy industry was investigated on a laboratory scale. Assessment was based primarily on the ability of the enzymes to remove an experimentally generated milk fouling deposit from stainless steel (SS) panels. Three protease products were identified as being most suitable for this application on the basis of their cleaning performance at 40 °C, which was comparable to that of the commonly used cleaning agent, 1% NaOH at 60 °C. This was judged by quantification of residual organic matter and protein on the SS surface after cleaning and analysis by laser scanning confocal microscopy (LSCM). Enzyme activity was removed/inactivated under conditions simulating those normally undertaken after cleaning (rinsing with water, acid circulation, sanitation). Preliminary process-scale studies strongly suggest that enzyme-based CIP achieves satisfactory cleaning at an industrial scale. Cost analysis indicates that replacing caustic-based cleaning procedures with biodegradable enzymes operating at lower temperatures would be economically viable. Additional potential benefits include decreased energy and water consumption, improved safety, reduced waste generation, greater compatibility with wastewater treatment processes and a reduction in the environmental impact of the cleaning process.

  12. Power system applications of high temperature superconductors

    NASA Astrophysics Data System (ADS)

    Garlick, W. G.

    This paper presents an overview of potential applications for high temperature superconductors (HTSs) in the field of power engineering. For almost 10 years material scientists, chemists and physicists have had the freedom to find, explore and characterize the properties of new HTS materials. 10 years is not a long time in the development of a revolutionary technology, but it seems like an age to the engineer who has recognized its potential and waits impatiently for the technology to stabilize in order to apply it. Largely due to Government and Industry partnerships, only a few years after the discovery of HTS, electrical power applications based on HTS are now being designed and tested. These applications offer many benefits to the resident electrical system: increased energy efficiency, smaller equipment, reduced emissions, increased stability and reliability, deferred expansion and flexible transmission and distribution. They have a common focus: lower electricity costs, improved environmental quality and more competitive products for a global market. For HTS to become a commercial success, the development of materials technologies is necessary but not sufficient on its own; the development of a capability to design and manufacture products that use the materials is also fundamental to a viable and successful industrial base.

  13. Blood flow, flow reserve, and glucose utilization in viable and nonviable myocardium in patients with ischemic cardiomyopathy

    PubMed Central

    Zhang, Xiaoli; Schindler, Thomas H.; Prior, John O.; Sayre, James; Dahlbom, Magnus; Huang, Sung-Cheng

    2016-01-01

    Purpose The aim of the study was to determine whether glucose uptake in viable myocardium of ischemic cardiomyopathy patients depends on rest myocardial blood flow (MBF) and the residual myocardial flow reserve (MFR). Methods Thirty-six patients with ischemic cardiomyopathy (left ventricular ejection fraction 25±10 %) were studied with 13N-ammonia and 18F-fluorodeoxyglucose (FDG) positron emission tomography (PET). Twenty age-matched normals served as controls. Regional MBF was determined at rest and during dipyridamole hyperemia and regional FDG extraction was estimated from regional FDG to 13N-ammonia activity ratios. Results Rest MBF was reduced in viable (0.42±0.18 ml/min per g) and nonviable regions (0.32±0.09 ml/min per g) relative to remote regions (0.68±0.23 ml/min per g, p<0.001) and to normals (0.63±0.13 ml/min per g). Dipyridamole raised MBFs in controls, remote, viable, and nonviable regions. MBFs at rest (p<0.05) and stress (p<0.05) in viable regions were significantly higher than that in nonviable regions, while MFRs did not differ significantly (p>0.05). Compared to MFR in remote myocardium, MFRs in viable regions were similar (1.39±0.56 vs 1.70±0.45, p>0.05) but were significantly lower in nonviable regions (1.23±0.43, p<0.001). Moreover, the FDG and thus glucose extraction was higher in viable than in remote (1.40±0.14 vs 0.90±0.20, p<0.001) and in nonviable regions (1.13±0.21, p<0.001). The extraction of FDG in viable regions was independent of rest MBF but correlated inversely with MFRs (r=−0.424, p<0.05). No correlation between the FDG extraction and MFR was observed in nonviable regions. Conclusion As in the animal model, decreasing MFRs in viable myocardium are associated with increasing glucose extraction that likely reflects a metabolic adaptation of remodeling hibernating myocytes. PMID:23287994

  14. Production of viable homozygous, doubled haploid channel catfish (Ictalurus punctatus)

    USDA-ARS?s Scientific Manuscript database

    Production of doubled haploids via mitotic gynogenesis is a useful tool for the creation of completely inbred fish. In order to produce viable doubled haploid channel catfish, we utilized hydrostatic pressure or thermal treatments on eggs fertilized with sperm that had been exposed to ultraviolet l...

  15. Comparison of mechanical compressive properties of commercial and autologous fibrin glues for tissue engineering applications.

    PubMed

    Cravens, Matthew G; Behn, Anthony W; Dragoo, Jason L

    2017-11-01

    Fibrin glues are widely used in orthopedic surgery as adhesives and hemostatic agents. We evaluated the compressive properties of selected fibrin glues in order to identify which are appropriate for tissue regeneration applications subject to compression. Uniaxial unconfined compression tests were performed on fibrin gels prepared from commercial and autologous products: (1) Evicel (Ethicon), (2) Tisseel (Baxter), (3) Angel (Arthrex), and (4) ProPlaz (Biorich). Cyclic loads were applied from 0 to 30% strain for 100cycles at 0.5Hz. Following cyclic testing, specimens were subjected to ramp displacement of 1% strain per second to 80% strain. Throughout cyclic loading, Evicel and Tisseel deformed (shortened) less than Angel at all but one time point, and deformed less than ProPlaz at cycles 10 and 20. The dynamic moduli, peak stress, and strain energy were significantly greater in Tisseel than all other groups. Evicel displayed significantly greater dynamic moduli, peak stress, and strain energy than Angel and ProPlaz. Following cyclic testing, Tisseel and Evicel were significantly less deformed than Angel. No specimens exhibited gross failure during ramp loading to 80% strain. Ramp loading trends mirrored those of cyclic loading. The tested commercial glues were significantly more resistant to compression than the autologous products. The compressive properties of Tisseel were approximately twice those of Evicel. All preparations displayed moduli multiple orders of magnitude less than that of native articular cartilage. We conclude that in knee surgeries requiring fibrin glue to undergo compression of daily activity, commercial products are preferable to autologous preparations from platelet-poor plasma, though both will deform significantly. Copyright © 2017 Elsevier Ltd. All rights reserved.

  16. Successful commercialization of nanophotonic technology

    NASA Astrophysics Data System (ADS)

    Jaiswal, Supriya L.; Clarke, Roger B. M.; Hyde, Sam C. W.

    2006-08-01

    The exploitation of nanotechnology from proof of principle to realizable commercial applications encounters considerable challenges in regards to high volume, large scale, low cost manufacturability and social ethics. This has led to concerns over converting powerful intellectual property into realizable, industry attractive technologies. At The Technology Partnership we specifically address the issue of successful integration of nanophotonics into industry in markets such as biomedical, ophthalmic, energy, telecommunications, and packaging. In this paper we draw on a few examples where we have either developed industrial scale nanophotonic technology or engineering platforms which may be used to fortify nano/microphotonic technologies and enhance their commercial viability.

  17. Enhanced energy harvesting in commercial ferroelectric materials

    NASA Astrophysics Data System (ADS)

    Patel, Satyanarayan; Chauhan, Aditya; Vaish, Rahul

    2014-04-01

    Ferroelectric materials are used in a number of applications ranging from simple sensors and actuators to ferroelectric random access memories (FRAMs), transducers, health monitoring system and microelectronics. The multiphysical coupling ability possessed by these materials has been established to be useful for energy harvesting applications. However, conventional energy harvesting techniques employing ferroelectric materials possess low energy density. This has prevented the successful commercialization of ferroelectric based energy harvesting systems. In this context, the present study aims at proposing a novel approach for enhanced energy harvesting using commercially available ferroelectric materials. This technique was simulated to be used for two commercially available piezoelectric materials namely PKI-552 and APCI-840, soft and hard lead-zirconate-titanate (PZT) pervoskite ceramics, respectively. It was observed that a maximum energy density of 348 kJm-3cycle-1 can be obtained for cycle parameters of (0-1 ton compressive stress and 1-25 kV.cm-1 electric field) using APCI-840. The reported energy density is several hundred times larger than the maximum energy density reported in the literature for vibration harvesting systems.

  18. 76 FR 126 - Requirement for Commercial Users To Use Commercial Public Key Information (PKI) Certificate

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-01-03

    ..., SDDC will require all commercial accounts accessing transportation systems and applications to use a...: Department of Defense Instruction number 8520.2, 1 April 2004, 4.4 Joint Task Force-Global Network Operations..._8520.2.pdf ). Randy Moore, CAPT, USN, Division Chief, G6, Information Management/CIO. [FR Doc. 2010...

  19. Commercial sector solid oxide fuel cell business assessment. Interim report

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Schafer, P.

    Estimates for the commercial potential of solid oxide fuel cells (SOFCs) from the year 2001 to 2015 is 4 billion MWh. Their quiet operation, low cost, efficiency, and small size could make SOFCs ideal power sources for commercial customers. To better understand the market, this study had three main objectives: (1) identify the extent of the commercial market potential; (2) describe the most likely commercial segments and locations for SOFCs to be competitive; and, (3) determine the most appropriate product sizes. To profile commercial sectors by energy use, investigators conducted a market segmentation analysis. They classified markets within sectors asmore » cogeneration and electric-only applications. Investigators then performed a market analysis to estimate the cost competitiveness of SOFC energy production by state, segment, and operating mode (cogeneration or electric-only). To determine which locations and sectors would be competitive with current utility retail rates, they used the cost per kWh of electrical energy produced by SOFC technology. Study results indicated that three sizes of SOFCs would meet most market capacity requirements: 20, 100, and 250 kW. The largest number of potential SOFC building applications fell into these sectors: education, health care, food service, and skilled nursing. In terms of competitive building applications, California, New York, Illinois, Texas, and Michigan were the top states. The potential market for SOFCs, however, could be much smaller if the pressures of deregulation decrease commercial retail rates or if the rates themselves increase more slowly than expected.« less

  20. HLA-targeted flow cytometric sorting of blood cells allows separation of pure and viable microchimeric cell populations.

    PubMed

    Drabbels, Jos J M; van de Keur, Carin; Kemps, Berit M; Mulder, Arend; Scherjon, Sicco A; Claas, Frans H J; Eikmans, Michael

    2011-11-10

    Microchimerism is defined by the presence of low levels of nonhost cells in a person. We developed a reliable method for separating viable microchimeric cells from the host environment. For flow cytometric cell sorting, HLA antigens were targeted with human monoclonal HLA antibodies (mAbs). Optimal separation of microchimeric cells (present at a proportion as low as 0.01% in artificial mixtures) was obtained with 2 different HLA mAbs, one targeting the chimeric cells and the other the background cells. To verify purity of separated cell populations, flow-sorted fractions of 1000 cells were processed for DNA analysis by HLA-allele-specific and Y-chromosome-directed real-time quantitative PCR assays. After sorting, PCR signals of chimeric DNA markers in the positive fractions were significantly enhanced compared with those in the presort samples, and they were similar to those in 100% chimeric control samples. Next, we demonstrate applicability of HLA-targeted FACS sorting after pregnancy by separating chimeric maternal cells from child umbilical cord mononuclear cells. Targeting allelic differences with anti-HLA mAbs with FACS sorting allows maximal enrichment of viable microchimeric cells from a background cell population. The current methodology enables reliable microchimeric cell detection and separation in clinical specimens.

  1. 15 CFR 971.203 - Commercial recovery plan.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... ENVIRONMENTAL DATA SERVICE DEEP SEABED MINING REGULATIONS FOR COMMERCIAL RECOVERY PERMITS Applications Contents... requirements for resource assessment and logical mining unit (§ 971.501); (6) A description of the methods and...

  2. 15 CFR 971.203 - Commercial recovery plan.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... ENVIRONMENTAL DATA SERVICE DEEP SEABED MINING REGULATIONS FOR COMMERCIAL RECOVERY PERMITS Applications Contents... requirements for resource assessment and logical mining unit (§ 971.501); (6) A description of the methods and...

  3. Coordinated Fuel Cell System Programs for Government and Commercial Applications: Are We in a New Era?

    NASA Technical Reports Server (NTRS)

    Warshay, Marvin; Prokopius, Paul

    1996-01-01

    Though the fuel cell was invented in 1839, it was not until the early 1960's that the fuel cell power system was developed and used for a real application, for the NASA Space Mission Gemini. Unfortunately, fuel cell power systems did not, as a result, become in widespread use. Nevertheless, a great deal of progress has been made by both government and industry, culminating in many successful fuel cell power system demonstrations. Initially, each government agency and each private organization went its own way. Later, it became evident that coordination among programs was essential. An overview is presented of the current coordinated efforts by government and industry in fuel cells, with a sufficient historical background. The primary barriers to coordination of programs were institutional and differing application requirements. Initially, in the institutional area, it was the energy crisis and the formation of DOE which fostered close working relationships among government, manufacturers, and users. The authors discuss the fuel cell power system programs (of NASA, DOE, DOT, DOC, EPRI, GRI, industry, and universities), including missions and applications, technology advances, and demonstrations. The discussion covers the new Solar Regenerative Fuel Cell (RFC) program which has space, defense, and commercial terrestrial applications, and which is an excellent example of both program coordination and the Clinton Administration's dual-use application policy.

  4. A commercially viable virtual reality knee arthroscopy training system.

    PubMed

    McCarthy, A D; Hollands, R J

    1998-01-01

    Arthroscopy is a minimally invasive form of surgery used to inspect joints. It is complex to learn yet current training methods appear inadequate, thus negating the potential benefits to the patient. This paper describes the development and initial assessment of a cost-effective virtual reality based system for training surgeons in arthroscopy of the knee. The system runs on a P.C. Initial assessments by surgeons have been positive and current developments in deformable models are described.

  5. Commercial objectives, technology transfer, and systems analysis for fusion power development

    NASA Astrophysics Data System (ADS)

    Dean, Stephen O.

    1988-09-01

    Fusion is an inexhaustible source of energy that has the potential for economic commercial applications with excellent safety and environmental characteristics. The primary focus for the fusion energy development program is the generation of central station electricity. Fusion has the potential, however, for many other applications. The fact that a large fraction of the energy released in a DT fusion reaction is carried by high energy neutrons suggests potentially unique applications. In addition, fusion R and D will lead to new products and new markets. Each fusion application must meet certain standards of economic and safety and environmental attractiveness. For this reason, economics on the one hand, and safety and environment and licensing on the other, are the two primary criteria for setting long range commercial fusion objectives. A major function of systems analysis is to evaluate the potential of fusion against these objectives and to help guide the fusion R and D program toward practical applications. The transfer of fusion technology and skills from the national labs and universities to industry is the key to achieving the long range objective of commercial fusion applications.

  6. Commercial objectives, technology transfer, and systems analysis for fusion power development

    NASA Technical Reports Server (NTRS)

    Dean, Stephen O.

    1988-01-01

    Fusion is an inexhaustible source of energy that has the potential for economic commercial applications with excellent safety and environmental characteristics. The primary focus for the fusion energy development program is the generation of central station electricity. Fusion has the potential, however, for many other applications. The fact that a large fraction of the energy released in a DT fusion reaction is carried by high energy neutrons suggests potentially unique applications. In addition, fusion R and D will lead to new products and new markets. Each fusion application must meet certain standards of economic and safety and environmental attractiveness. For this reason, economics on the one hand, and safety and environment and licensing on the other, are the two primary criteria for setting long range commercial fusion objectives. A major function of systems analysis is to evaluate the potential of fusion against these objectives and to help guide the fusion R and D program toward practical applications. The transfer of fusion technology and skills from the national labs and universities to industry is the key to achieving the long range objective of commercial fusion applications.

  7. The importance of the viable but non-culturable state in human bacterial pathogens

    PubMed Central

    Li, Laam; Mendis, Nilmini; Trigui, Hana; Oliver, James D.; Faucher, Sebastien P.

    2014-01-01

    Many bacterial species have been found to exist in a viable but non-culturable (VBNC) state since its discovery in 1982. VBNC cells are characterized by a loss of culturability on routine agar, which impairs their detection by conventional plate count techniques. This leads to an underestimation of total viable cells in environmental or clinical samples, and thus poses a risk to public health. In this review, we present recent findings on the VBNC state of human bacterial pathogens. The characteristics of VBNC cells, including the similarities and differences to viable, culturable cells and dead cells, and different detection methods are discussed. Exposure to various stresses can induce the VBNC state, and VBNC cells may be resuscitated back to culturable cells under suitable stimuli. The conditions that trigger the induction of the VBNC state and resuscitation from it are summarized and the mechanisms underlying these two processes are discussed. Last but not least, the significance of VBNC cells and their potential influence on human health are also reviewed. PMID:24917854

  8. Application of Raman spectroscopy to identification and sorting of post-consumer plastics for recycling

    DOEpatents

    Sommer, Edward J.; Rich, John T.

    2001-01-01

    A high accuracy rapid system for sorting a plurality of waste products by polymer type. The invention involves the application of Raman spectroscopy and complex identification techniques to identify and sort post-consumer plastics for recycling. The invention reads information unique to the molecular structure of the materials to be sorted to identify their chemical compositions and uses rapid high volume sorting techniques to sort them into product streams at commercially viable throughput rates. The system employs a laser diode (20) for irradiating the material sample (10), a spectrograph (50) is used to determine the Raman spectrum of the material sample (10) and a microprocessor based controller (70) is employed to identify the polymer type of the material sample (10).

  9. Cosmological constraints and comparison of viable f (R ) models

    NASA Astrophysics Data System (ADS)

    Pérez-Romero, Judit; Nesseris, Savvas

    2018-01-01

    In this paper we present cosmological constraints on several well-known f (R ) models, but also on a new class of models that are variants of the Hu-Sawicki one of the form f (R )=R -2/Λ 1 +b y (R ,Λ ) , that interpolate between the cosmological constant model and a matter dominated universe for different values of the parameter b , which is usually expected to be small for viable models and which in practice measures the deviation from general relativity. We use the latest growth rate, cosmic microwave background, baryon acoustic oscillations, supernovae type Ia and Hubble parameter data to place stringent constraints on the models and to compare them to the cosmological constant model but also other viable f (R ) models such as the Starobinsky or the degenerate hypergeometric models. We find that these kinds of Hu-Sawicki variant parametrizations are in general compatible with the currently available data and can provide useful toy models to explore the available functional space of f (R ) models, something very useful with the current and upcoming surveys that will test deviations from general relativity.

  10. Use of Commercial Electrical, Electronic and Electromechanical (EEE) Parts in NASA's Commercial Crew Program (CCP)

    NASA Technical Reports Server (NTRS)

    Gonzalex, Oscar

    2012-01-01

    NASA's Commercial Crew and Cargo Program (CCP) is stimulating efforts within the private sector to develop and demonstrate safe, reliable, and cost-effective space transportation capabilities. One initiative involves investigating the use of commercial electronic parts. NASA's CCP asked the NASA Engineering and Safety Center (NESC) to collect data to help frame the technical, cost, and schedule risk trades associated with electrical, electronic and electromechanical (EEE) parts selection and specifically expressed desire of some of the CCP partners to employ EEE parts of a lower grade than traditionally used in most NASA safety-critical applications. This document contains the outcome from the NESC's review and analyses.

  11. NASA's commercial research plans and opportunities

    NASA Technical Reports Server (NTRS)

    Arnold, Ray J.

    1992-01-01

    One of the primary goals of the National Aeronautics and Space Administration's (NASA) commercial space development plan is to encourage the development of space-based products and markets, along with the infrastructure and transportation that will support those products and markets. A three phased program has been instituted to carry out this program. The first phase utilizes government grants through the Centers for the Commercial Development of Space (CCDS) for space-related, industry driven research; the development of a technology data base; and the development of commercial space transportation and infrastructure. The second phase includes the development of these technologies by industry for new commercial markets, and features unique industry/government collaborations such as Joint Endeavor Agreements. The final phase will feature technical applications actually brought to the marketplace. The government's role will be to support industry required infrastructure to encourage start-up markets and industries through follow-on development agreements such as the Space Systems Development Agreement. The Office of Commercial Programs has an aggressive flight program underway on the Space Shuttle, suborbital rockets, orbital expendable launch vehicles, and the Commercial Middeck Accommodation Module with SPACEHAB Inc. The Office of Commercial Program's has been allocated 35 percent of the U.S. share of the Space Station Freedom resources for 1997 utilization. A utilization plan has been developed with the Centers for the Commercial Development of Space and has identified eleven materials processing and biotechnology payloads occupying 5 double racks in the pressurized module as well as two payloads external to the module in materials exposure and environment monitoring. The Office of Commercial Programs will rely on the Space Station Freedom to provide the long duration laboratory component for space-based commercial research.

  12. NASA's commercial research plans and opportunities

    NASA Astrophysics Data System (ADS)

    Arnold, Ray J.

    One of the primary goals of the National Aeronautics and Space Administration's (NASA) commercial space development plan is to encourage the development of space-based products and markets, along with the infrastructure and transportation that will support those products and markets. A three phased program has been instituted to carry out this program. The first phase utilizes government grants through the Centers for the Commercial Development of Space (CCDS) for space-related, industry driven research; the development of a technology data base; and the development of commercial space transportation and infrastructure. The second phase includes the development of these technologies by industry for new commercial markets, and features unique industry/government collaborations such as Joint Endeavor Agreements. The final phase will feature technical applications actually brought to the marketplace. The government's role will be to support industry required infrastructure to encourage start-up markets and industries through follow-on development agreements such as the Space Systems Development Agreement. The Office of Commercial Programs has an aggressive flight program underway on the Space Shuttle, suborbital rockets, orbital expendable launch vehicles, and the Commercial Middeck Accommodation Module with SPACEHAB Inc. The Office of Commercial Program's has been allocated 35 percent of the U.S. share of the Space Station Freedom resources for 1997 utilization. A utilization plan has been developed with the Centers for the Commercial Development of Space and has identified eleven materials processing and biotechnology payloads occupying 5 double racks in the pressurized module as well as two payloads external to the module in materials exposure and environment monitoring. The Office of Commercial Programs will rely on the Space Station Freedom to provide the long duration laboratory component for space-based commercial research.

  13. Assessments of Total and Viable Escherichia coli O157:H7 on Field and Laboratory Grown Lettuce

    PubMed Central

    Moyne, Anne-Laure; Harris, Linda J.; Marco, Maria L.

    2013-01-01

    Leafy green produce has been associated with numerous outbreaks of foodborne illness caused by strains of Escherichia coli O157:H7. While the amounts of culturable E. coli O157:H7 rapidly decline after introduction onto lettuce in the field, it remains to be determined whether the reduction in cell numbers is due to losses in cell viability, cell injury and a subsequent inability to be detected by standard laboratory culturing methods, or a lack of adherence and hence rapid removal of the organism from the plants during application. To assess which of these options is most relevant for E. coli O157:H7 on leafy green produce, we developed and applied a propidium monoazide (PMA) real-time PCR assay to quantify viable (with PMA) and total (without PMA) E. coli O157:H7 cells on growth chamber and field-grown lettuce. E. coli O157:H7, suspended in 0.1% peptone, was inoculated onto 4-week-old lettuce plants at a level of approximately 106 CFU/plant. In the growth chamber at low relative humidity (30%), culturable amounts of the nontoxigenic E. coli O157:H7 strain ATCC 700728 and the virulent strain EC4045 declined 100 to 1000-fold in 24 h. Fewer E. coli O157:H7 cells survived when applied onto plants in droplets with a pipette compared with a fine spray inoculation. Total cells for both strains were equivalent to inoculum levels for 7 days after application, and viable cell quantities determined by PMA real-time PCR were approximately 104 greater than found by colony enumeration. Within 2 h after application onto plants in the field, the number of culturable E. coli ATCC 700728 was reduced by up to 1000-fold, whereas PCR-based assessments showed that total cell amounts were equivalent to inoculum levels. These findings show that shortly after inoculation onto plants, the majority of E. coli O157:H7 cells either die or are no longer culturable. PMID:23936235

  14. Continuous country-wide rainfall observation using a large network of commercial microwave links: Challenges, solutions and applications

    NASA Astrophysics Data System (ADS)

    Chwala, Christian; Boose, Yvonne; Smiatek, Gerhard; Kunstmann, Harald

    2017-04-01

    Commercial microwave link (CML) networks have proven to be a valuable source for rainfall information over the last years. However, up to now, analysis of CML data was always limited to certain snapshots of data for historic periods due to limited data access. With the real-time availability of CML data in Germany (Chwala et al. 2016) this situation has improved significantly. We are continuously acquiring and processing data from 3000 CMLs in Germany in near real-time with one minute temporal resolution. Currently the data acquisition system is extended to 10000 CMLs so that the whole of Germany is covered and a continuous country-wide rainfall product can be provided. In this contribution we will elaborate on the challenges and solutions regarding data acquisition, data management and robust processing. We will present the details of our data acquisition system that we run operationally at the network of the CML operator Ericsson Germany to solve the problem of limited data availability. Furthermore we will explain the implementation of our data base, its web-frontend for easy data access and present our data processing algorithms. Finally we will showcase an application of our data in hydrological modeling and its potential usage to improve radar QPE. Bibliography: Chwala, C., Keis, F., and Kunstmann, H.: Real-time data acquisition of commercial microwave link networks for hydrometeorological applications, Atmos. Meas. Tech., 9, 991-999, doi:10.5194/amt-9-991-2016, 2016

  15. Research and test facilities for development of technologies and experiments with commercial applications

    NASA Technical Reports Server (NTRS)

    1989-01-01

    One of NASA'S agency-wide goals is the commercial development of space. To further this goal NASA is implementing a policy whereby U.S. firms are encouraged to utilize NASA facilities to develop and test concepts having commercial potential. Goddard, in keeping with this policy, will make the facilities and capabilities described in this document available to private entities at a reduced cost and on a noninterference basis with internal NASA programs. Some of these facilities include: (1) the Vibration Test Facility; (2) the Battery Test Facility; (3) the Large Area Pulsed Solar Simulator Facility; (4) the High Voltage Testing Facility; (5) the Magnetic Field Component Test Facility; (6) the Spacecraft Magnetic Test Facility; (7) the High Capacity Centrifuge Facility; (8) the Acoustic Test Facility; (9) the Electromagnetic Interference Test Facility; (10) the Space Simulation Test Facility; (11) the Static/Dynamic Balance Facility; (12) the High Speed Centrifuge Facility; (13) the Optical Thin Film Deposition Facility; (14) the Gold Plating Facility; (15) the Paint Formulation and Application Laboratory; (16) the Propulsion Research Laboratory; (17) the Wallops Range Facility; (18) the Optical Instrument Assembly and Test Facility; (19) the Massively Parallel Processor Facility; (20) the X-Ray Diffraction and Scanning Auger Microscopy/Spectroscopy Laboratory; (21) the Parts Analysis Laboratory; (22) the Radiation Test Facility; (23) the Ainsworth Vacuum Balance Facility; (24) the Metallography Laboratory; (25) the Scanning Electron Microscope Laboratory; (26) the Organic Analysis Laboratory; (27) the Outgassing Test Facility; and (28) the Fatigue, Fracture Mechanics and Mechanical Testing Laboratory.

  16. Dendritic cells for active immunotherapy: optimizing design and manufacture in order to develop commercially and clinically viable products.

    PubMed

    Nicolette, C A; Healey, D; Tcherepanova, I; Whelton, P; Monesmith, T; Coombs, L; Finke, L H; Whiteside, T; Miesowicz, F

    2007-09-27

    Dendritic cell (DC) active immunotherapy is potentially efficacious in a broad array of malignant disease settings. However, challenges remain in optimizing DC-based therapy for maximum clinical efficacy within manufacturing processes that permit quality control and scale-up of consistent products. In this review we discuss the critical issues that must be addressed in order to optimize DC-based product design and manufacture, and highlight the DC based platforms currently addressing these issues. Variables in DC-based product design include the type of antigenic payload used, DC maturation steps and activation processes, and functional assays. Issues to consider in development include: (a) minimizing the invasiveness of patient biological material collection; (b) minimizing handling and manipulations of tissue at the clinical site; (c) centralized product manufacturing and standardized processing and capacity for commercial-scale production; (d) rapid product release turnaround time; (e) the ability to manufacture sufficient product from limited starting material; and (f) standardized release criteria for DC phenotype and function. Improvements in the design and manufacture of DC products have resulted in a handful of promising leads currently in clinical development.

  17. Industrial viable process of making nanoparticles of various shapes and interior structures

    NASA Astrophysics Data System (ADS)

    Wang, Xiaorong

    2008-03-01

    Over the past 10 years, we attempted to develop industrial viable processes which were of significance in manufacturing the nanoparticles in good quality and large volume. Our effort relied on the self-assembly concepts of block macromolecules in solutions to prepare particles with a hard core made of crosslinked plastics and a soft shell made of low Tg elastomer. Depending on the type and microstructure of the copolymers, the solvent concentration and other process parameters chosen, a variety of shell-core nano-particles of different shapes (spheres, hollow spheres, ellipsoids, cylinders, linear and branched strings, disks and etc.) and sizes (5-100 nm diameter) were reproducibly synthesized. Scale-up studies led to an optimization of the manufacturing process and the production of nanoparticles in large quantities for various product application efforts. The unique performance of those nanoparticles as performance tuning additives and novel rubber reinforcing elements was explored in rubber compounds. This review describes the synthesis methods used to produce the polymer nanoparticles, the technology to modify the particles through functionalization, the means to optimize their performance for specific applications, and the methods to use those particles in rubber compounds. Collaborators: Victor J. Foltz, Kurasch Jessica, Chenchy J. Lin, Jeff Magestrelli, Sandra Warren, Alberto Scuratti, James E. Hall, Jim Krom, Mindaugas Rackaitis, Michael W. Hayes, Pat Sadhukhan, Georg G. A. Bohm

  18. Hole filling and library optimization: application to commercially available fragment libraries.

    PubMed

    An, Yuling; Sherman, Woody; Dixon, Steven L

    2012-09-15

    Compound libraries comprise an integral component of drug discovery in the pharmaceutical and biotechnology industries. While in-house libraries often contain millions of molecules, this number pales in comparison to the accessible space of drug-like molecules. Therefore, care must be taken when adding new compounds to an existing library in order to ensure that unexplored regions in the chemical space are filled efficiently while not needlessly increasing the library size. In this work, we present an automated method to fill holes in an existing library using compounds from an external source and apply it to commercially available fragment libraries. The method, called Canvas HF, uses distances computed from 2D chemical fingerprints and selects compounds that fill vacuous regions while not suffering from the problem of selecting only compounds at the edge of the chemical space. We show that the method is robust with respect to different databases and the number of requested compounds to retrieve. We also present an extension of the method where chemical properties can be considered simultaneously with the selection process to bias the compounds toward a desired property space without imposing hard property cutoffs. We compare the results of Canvas HF to those obtained with a standard sphere exclusion method and with random compound selection and find that Canvas HF performs favorably. Overall, the method presented here offers an efficient and effective hole-filling strategy to augment compound libraries with compounds from external sources. The method does not have any fit parameters and therefore it should be applicable in most hole-filling applications. Copyright © 2012 Elsevier Ltd. All rights reserved.

  19. A USNRC perspective on the use of commercial-off-shelf software (COTS) in advanced reactors

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Stewart, J.C.

    1997-12-01

    The use of commercially available digital computer systems and components in safety critical systems (nuclear power plant, military, and commercial applications) is increasing rapidly. While this paper focuses on the software aspects of the application most of these continents are applicable to the hardware aspects as well. Commercial dedication (the process of assuring that a commercial grade item will perform its intended safety function) has demonstrated benefits in cost savings and a wide base of user experience, however, care must be taken to avoid difficulties with some aspects of the dedication process such as access to vendor development information, configurationmore » management long term support, and system integration.« less

  20. Digimarc MediaBridge: the birth of a consumer product from concept to commercial application

    NASA Astrophysics Data System (ADS)

    Perry, Burt; MacIntosh, Brian; Cushman, David

    2002-04-01

    This paper examines the issues encountered in the development and commercial deployment of a system based on digital watermarking technology. The paper provides an overview of the development of digital watermarking technology and the first applications to use the technology. It also looks at how we took the concept of digital watermarking as a communications channel within a digital environment and applied it to the physical print world to produce the Digimarc MediaBridge product. We describe the engineering tradeoffs that were made to balance competing requirements of watermark robustness, image quality, embedding process, detection speed and end user ease of use. Today, the Digimarc MediaBridge product links printed materials to auxiliary information about the content, via the Internet, to provide enhanced informational marketing, promotion, advertising and commerce opportunities.

  1. Blood flow, flow reserve, and glucose utilization in viable and nonviable myocardium in patients with ischemic cardiomyopathy.

    PubMed

    Zhang, Xiaoli; Schindler, Thomas H; Prior, John O; Sayre, James; Dahlbom, Magnus; Huang, Sung-Cheng; Schelbert, Heinrich R

    2013-04-01

    The aim of the study was to determine whether glucose uptake in viable myocardium of ischemic cardiomyopathy patients depends on rest myocardial blood flow (MBF) and the residual myocardial flow reserve (MFR). Thirty-six patients with ischemic cardiomyopathy (left ventricular ejection fraction 25 ± 10 %) were studied with (13)N-ammonia and (18)F-fluorodeoxyglucose (FDG) positron emission tomography (PET). Twenty age-matched normals served as controls. Regional MBF was determined at rest and during dipyridamole hyperemia and regional FDG extraction was estimated from regional FDG to (13)N-ammonia activity ratios. Rest MBF was reduced in viable (0.42 ± 0.18 ml/min per g) and nonviable regions (0.32 ± 0.09 ml/min per g) relative to remote regions (0.68 ± 0.23 ml/min per g, p < 0.001) and to normals (0.63 ± 0.13 ml/min per g). Dipyridamole raised MBFs in controls, remote, viable, and nonviable regions. MBFs at rest (p < 0.05) and stress (p < 0.05) in viable regions were significantly higher than that in nonviable regions, while MFRs did not differ significantly (p > 0.05). Compared to MFR in remote myocardium, MFRs in viable regions were similar (1.39 ± 0.56 vs 1.70 ± 0.45, p > 0.05) but were significantly lower in nonviable regions (1.23 ± 0.43, p < 0.001). Moreover, the FDG and thus glucose extraction was higher in viable than in remote (1.40 ± 0.14 vs 0.90 ± 0.20, p < 0.001) and in nonviable regions (1.13 ± 0.21, p < 0.001). The extraction of FDG in viable regions was independent of rest MBF but correlated inversely with MFRs (r =-0.424, p < 0.05). No correlation between the FDG extraction and MFR was observed in nonviable regions. As in the animal model, decreasing MFRs in viable myocardium are associated with increasing glucose extraction that likely reflects a metabolic adaptation of remodeling hibernating myocytes.

  2. 77 FR 59344 - Fisheries of the Caribbean, Gulf of Mexico, and South Atlantic; 2012 Commercial Accountability...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-09-27

    ... the commercial annual catch limit (ACL) on September 28, 2012. Therefore, NMFS closes the commercial... Management Act (Magnuson- Stevens Act) by regulations at 50 CFR part 622. The commercial ACL (commercial... vermilion snapper when the commercial ACL (commercial quota) for the applicable portion of the fishing year...

  3. Certification Process for Commercial Batteries for Payloads

    NASA Technical Reports Server (NTRS)

    Jeevarajan, Judith

    2007-01-01

    This viewgraph document reviews the use of electric batteries in space applications. Batteries are high energy devices that are used to power hardware for space applications The applications include IVA (Intra-Vehicular Activity) and EVA (Extra-Vehicular Activity) use. High energy batteries pose hazards such as cell/battery venting leading to electrolyte (liquid or gas) leakage, high temperatures, fire and explosion (shrapnel). It reviews the process of certifying of Commercial batteries for space applications in view of the multi-national purchasing for the International Space Station. The documentation used in the certification is reviewed.

  4. Energy conservation and the residential and commercial sector

    NASA Technical Reports Server (NTRS)

    1975-01-01

    A detailed analysis of energy conservation actions relevant to the residential and commercial sector has led to the conclusion that the potential for savings is great. The task will not be easy, however, since many of the actions require significant life style changes that are difficult to accomplish. Furthermore, many of the conservation actions cited as instant solutions to the energy crisis are those with only mid to long term potential, such as solar energy or heat pumps. Three significant conservation approaches are viable: adjusting price structure, mandating actions, and educating consumers. The first two appear to be the most feasible. But they are not without a price. Higher utility bills adversely affect the poor and the elderly on fixed incomes. Likewise, strict mandatory measures can be quite distasteful. But the effect of alternatives, such as voluntary savings accomplished through education processes, is minimal in a nation without a true conservation ethic.

  5. Enhanced ethanol production at commercial scale from molasses using high gravity technology by mutant S. cerevisiae.

    PubMed

    Arshad, Muhammad; Hussain, Tariq; Iqbal, Munawar; Abbas, Mazhar

    Very high gravity (VHG) technology was employed on industrial scale to produce ethanol from molasses (fermented) as well as by-products formation estimation. The effect of different Brix° (32, 36 and 40) air-flow rates (0.00, 0.20, 0.40, and 0.60vvm) was studied on ethanol production. The maximum ethanol production was recorded to be 12.2% (v/v) at 40 Brix° with 0.2vvm air-flow rate. At optimum level aeration and 40 Brix° VHG, the residual sugar level was recorded in the range of 12.5-18.5g/L, whereas the viable cell count remained constant up to 50h of fermentation and dry matter production increased with fermentation time. Both water and steam consumption reduced significantly under optimum conditions of Brix° and aeration rate with compromising the ethanol production. Results revealed VHG with continuous air flow is viable technique to reduce the ethanol production cost form molasses at commercial scale. Copyright © 2017. Published by Elsevier Editora Ltda.

  6. Characteristics of Viable and Sustainable Workers for the Year 2015.

    ERIC Educational Resources Information Center

    Dean, Brenda Pennington; West, Russell

    A two-round Delphi study was conducted to identify the characteristics of viable and sustainable employees in northeastern Tennessee in 2015. The Delphi panel selected for the study consisted of 25 experts who represented a cross-section of the businesses and communities in the 10-county area of northeastern Tennessee served by Walters State…

  7. Real-time data acquisition of commercial microwave link networks for hydrometeorological applications

    NASA Astrophysics Data System (ADS)

    Chwala, Christian; Keis, Felix; Kunstmann, Harald

    2016-03-01

    The usage of data from commercial microwave link (CML) networks for scientific purposes is becoming increasingly popular, in particular for rain rate estimation. However, data acquisition and availability is still a crucial problem and limits research possibilities. To overcome this issue, we have developed an open-source data acquisition system based on the Simple Network Management Protocol (SNMP). It is able to record transmitted and received signal levels of a large number of CMLs simultaneously with a temporal resolution of up to 1 s. We operate this system at Ericsson Germany, acquiring data from 450 CMLs with minutely real-time transfer to our database. Our data acquisition system is not limited to a particular CML hardware model or manufacturer, though. We demonstrate this by running the same system for CMLs of a different manufacturer, operated by an alpine ski resort in Germany. There, the data acquisition is running simultaneously for four CMLs with a temporal resolution of 1 s. We present an overview of our system, describe the details of the necessary SNMP requests and show results from its operational application.

  8. Real time data acquisition of commercial microwave link networks for hydrometeorological applications

    NASA Astrophysics Data System (ADS)

    Chwala, C.; Keis, F.; Kunstmann, H.

    2015-11-01

    The usage of data from commercial microwave link (CML) networks for scientific purposes is becoming increasingly popular, in particular for rain rate estimation. However, data acquisition and availability is still a crucial problem and limits research possibilities. To overcome this issue, we have developed an open source data acquisition system based on the Simple Network Management Protocol (SNMP). It is able to record transmitted- and received signal levels of a large number of CMLs simultaneously with a temporal resolution of up to one second. We operate this system at Ericsson Germany, acquiring data from 450 CMLs with minutely real time transfer to our data base. Our data acquisition system is not limited to a particular CML hardware model or manufacturer, though. We demonstrate this by running the same system for CMLs of a different manufacturer, operated by an alpine skiing resort in Germany. There, the data acquisition is running simultaneously for four CMLs with a temporal resolution of one second. We present an overview of our system, describe the details of the necessary SNMP requests and show results from its operational application.

  9. Large Scale Application of Vibration Sensors for Fan Monitoring at Commercial Layer Hen Houses

    PubMed Central

    Chen, Yan; Ni, Ji-Qin; Diehl, Claude A.; Heber, Albert J.; Bogan, Bill W.; Chai, Li-Long

    2010-01-01

    Continuously monitoring the operation of each individual fan can significantly improve the measurement quality of aerial pollutant emissions from animal buildings that have a large number of fans. To monitor the fan operation by detecting the fan vibration is a relatively new technique. A low-cost electronic vibration sensor was developed and commercialized. However, its large scale application has not yet been evaluated. This paper presents long-term performance results of this vibration sensor at two large commercial layer houses. Vibration sensors were installed on 164 fans of 130 cm diameter to continuously monitor the fan on/off status for two years. The performance of the vibration sensors was compared with fan rotational speed (FRS) sensors. The vibration sensors exhibited quick response and high sensitivity to fan operations and therefore satisfied the general requirements of air quality research. The study proved that detecting fan vibration was an effective method to monitor the on/off status of a large number of single-speed fans. The vibration sensor itself was $2 more expensive than a magnetic proximity FRS sensor but the overall cost including installation and data acquisition hardware was $77 less expensive than the FRS sensor. A total of nine vibration sensors failed during the study and the failure rate was related to the batches of product. A few sensors also exhibited unsteady sensitivity. As a new product, the quality of the sensor should be improved to make it more reliable and acceptable. PMID:22163544

  10. Design and dosimetry characteristics of a commercial applicator system for intra-operative electron beam therapy utilizing ELEKTA Precise accelerator.

    PubMed

    Nevelsky, Alexander; Bernstein, Zvi; Bar-Deroma, Raquel; Kuten, Abraham; Orion, Itzhak

    2010-07-19

    The design concept and dosimetric characteristics of a new applicator system for intraoperative radiation therapy (IORT) are presented in this work. A new hard-docking commercial system includes polymethylmethacrylate (PMMA) applicators with different diameters and applicator end angles and a set of secondary lead collimators. A telescopic device allows changing of source-to-surface distance (SSD). All measurements were performed for 6, 9, 12 and 18 MeV electron energies. Output factors and percentage depth doses (PDD) were measured in a water phantom using a plane-parallel ion chamber. Isodose contours and radiation leakage were measured using a solid water phantom and radiographic films. The dependence of PDD on SSD was checked for the applicators with the smallest and the biggest diameters. SSD dependence of the output factors was measured. Hardcopies of PDD and isodose contours were prepared to help the team during the procedure on deciding applicator size and energy to be chosen. Applicator output factors are a function of energy, applicator size and applicator type. Dependence of SSD correction factors on applicator size and applicator type was found to be weak. The same SSD correction will be applied for all applicators in use for each energy. The radiation leakage through the applicators is clinically acceptable. The applicator system enables effective collimation of electron beams for IORT. The data presented are sufficient for applicator, energy and monitor unit selection for IORT treatment of a patient.

  11. TechTracS: NASA's commercial technology management system

    NASA Astrophysics Data System (ADS)

    Barquinero, Kevin; Cannon, Douglas

    1996-03-01

    The Commercial Technology Mission is a primary NASA mission, comparable in importance to those in aeronautics and space. This paper will discuss TechTracS, NASA Commercial Technology Management System that has been put into place in FY 1995 to implement this mission. This system is designed to identify and capture the NASA technologies which have commercial potential into an off-the-shelf database application, and then track the technologies' progress in realizing the commercial potential through collaborations with industry. The management system consists of four stages. The first is to develop an inventory database of the agency's entire technology portfolio and assess it for relevance to the commercial marketplace. Those technologies that are identified as having commercial potential will then be actively marketed to appropriate industries—this is the second stage. The third stage is when a NASA-industry partnership is entered into for the purposes of commercializing the technology. The final stage is to track the technology's success or failure in the marketplace. The collection of this information in TechTracS enables metrics evaluation and can accelerate the establishment on direct contacts between and NASA technologist and an industry technologist. This connection is the beginning of the technology commercialization process.

  12. Comparison of culture-based, vital stain and PMA-qPCR methods for the quantitative detection of viable hookworm ova.

    PubMed

    Gyawali, P; Sidhu, J P S; Ahmed, W; Jagals, P; Toze, S

    2017-06-01

    Accurate quantitative measurement of viable hookworm ova from environmental samples is the key to controlling hookworm re-infections in the endemic regions. In this study, the accuracy of three quantitative detection methods [culture-based, vital stain and propidium monoazide-quantitative polymerase chain reaction (PMA-qPCR)] was evaluated by enumerating 1,000 ± 50 Ancylostoma caninum ova in the laboratory. The culture-based method was able to quantify an average of 397 ± 59 viable hookworm ova. Similarly, vital stain and PMA-qPCR methods quantified 644 ± 87 and 587 ± 91 viable ova, respectively. The numbers of viable ova estimated by the culture-based method were significantly (P < 0.05) lower than vital stain and PMA-qPCR methods. Therefore, both PMA-qPCR and vital stain methods appear to be suitable for the quantitative detection of viable hookworm ova. However, PMA-qPCR would be preferable over the vital stain method in scenarios where ova speciation is needed.

  13. Design of high entropy alloys based on the experience from commercial superalloys

    NASA Astrophysics Data System (ADS)

    Wang, Z.; Huang, Y.; Wang, J.; Liu, C. T.

    2015-01-01

    High entropy alloys (HEAs) have been drawing increasing attention recently and gratifying results have been obtained. However, the existing metallurgic rules of HEAs could not provide specific information of selecting candidate alloys for structural applications. Our brief survey reveals that many commercial superalloys have medium and even to high configurational entropies. The experience of commercial superalloys provides a clue for helping us in the development of HEAs for structural applications.

  14. Commercial applications for optical data storage

    NASA Astrophysics Data System (ADS)

    Tas, Jeroen

    1991-03-01

    Optical data storage has spurred the market for document imaging systems. These systems are increasingly being used to electronically manage the processing, storage and retrieval of documents. Applications range from straightforward archives to sophisticated workflow management systems. The technology is developing rapidly and within a few years optical imaging facilities will be incorporated in most of the office information systems. This paper gives an overview of the status of the market, the applications and the trends of optical imaging systems.

  15. Commercial associative memory performance for applications in track-based triggers at the Large Hadron Collider

    NASA Astrophysics Data System (ADS)

    Webster, Jordan

    2017-01-01

    Dense track environments in pp collisions at the Large Hadron Collider (LHC) motivate the use of triggers with dedicated hardware for fast track reconstruction. The ATLAS Collaboration is in the process of implementing a Fast Tracker (FTK) trigger upgrade, in which Content Addressable Memories (CAMs) will be used to rapidly match hit patterns with large banks of simulated tracks. The FTK CAMs are produced primarily at the University of Pisa. However, commercial CAM technology is rapidly developing due to applications in computer networking devices. This poster presents new studies comparing FTK CAMs to cutting-edge ternary CAMs developed by Cavium. The comparison is intended to guide the design of future track-based trigger systems for the next Phase at the LHC.

  16. Severe Plastic Deformation of Commercial Pure Titanium (CP-Ti) for Biomedical Applications: A Brief Review

    NASA Astrophysics Data System (ADS)

    Mahmoodian, Reza; Annuar, N. Syahira M.; Faraji, Ghader; Bahar, Nadia Dayana; Razak, Bushroa Abd; Sparham, Mahdi

    2017-11-01

    This paper reviews severe plastic deformation (SPD) techniques for producing ultrafine-grained (UFG) and nanostructured commercial pure titanium (CP-Ti) for biomedical applications as the best alternative to titanium alloys. SPD processes, effective parameters, and advantages of nanostructured CP-Ti over coarse-grained (CG) material and Ti alloys are briefly reviewed. It is reported that nanostructured CP-Ti processed via SPD exhibits higher mechanical strength comparable to Ti alloys but better biological response and superior biocompatibility. Also, different surface modification techniques offer different results on UFG and CG CP-Ti, leading to nanoscale surface topography in UFG samples. Overall, it is reported that nanostructured CP-Ti processed by SPD could be considered to be the best candidate for biomedical implants.

  17. Determining the efficacy of microsatellite DNA-based mixed-stock analysis of Lake Michigan’s lake whitefish commercial fishery

    USGS Publications Warehouse

    VanDeHey, Justin A.; Sloss, Brian L.; Peeters, Paul J.; Sutton, Trent M.

    2009-01-01

    Management of commercially exploited fish should be conducted at the stock level. If a mixed stock fishery exists, a comprehensive mixed stock analysis is required for stock-based management. The lake whitefish Coregonus clupeaformis comprises the primary commercial fishery across the Great Lakes. Recent research resolved that six genetic stocks of lake whitefish were present in Lake Michigan, and long-term tagging data indicate that Lake Michigan's lake whitefish commercial fishery is a mixed stock fishery. The objective of this research was to determine the usefulness of microsatellite data for conducting comprehensive mixed stock analyses of the Lake Michigan lake whitefish commercial fishery. We used the individual assignment method as implemented in the program ONCOR to determine the accuracy level at which microsatellite data can reliably identify component populations or stocks. Self-assignment of lake whitefish to their population and stock of origin ranged from > 96% to 100%. Evaluation of genetic stock discreteness indicated a moderately high degree of correct assignment (average = 75%); simulations indicated supplementing baseline data by ∼ 50 to 100 individuals could increase accuracy by up to 4.5%. Simulated mixed stock commercial harvests with known stock composition showed a high degree of correct proportional assignment between observed and predicted harvest values. These data suggest that a comprehensive mixed stock analysis of Lake Michigan's lake whitefish commercial fishery is viable and would provide valuable information for improving management.

  18. Strategies for improving production performance of probiotic Pediococcus acidilactici viable cell by overcoming lactic acid inhibition.

    PubMed

    Othman, Majdiah; Ariff, Arbakariya B; Wasoh, Helmi; Kapri, Mohd Rizal; Halim, Murni

    2017-11-27

    Lactic acid bacteria are industrially important microorganisms recognized for fermentative ability mostly in their probiotic benefits as well as lactic acid production for various applications. Fermentation conditions such as concentration of initial glucose in the culture, concentration of lactic acid accumulated in the culture, types of pH control strategy, types of aeration mode and different agitation speed had influenced the cultivation performance of batch fermentation of Pediococcus acidilactici. The maximum viable cell concentration obtained in constant fed-batch fermentation at a feeding rate of 0.015 L/h was 6.1 times higher with 1.6 times reduction in lactic acid accumulation compared to batch fermentation. Anion exchange resin, IRA 67 was found to have the highest selectivity towards lactic acid compared to other components studied. Fed-batch fermentation of P. acidilactici coupled with lactic acid removal system using IRA 67 resin showed 55.5 and 9.1 times of improvement in maximum viable cell concentration compared to fermentation without resin for batch and fed-batch mode respectively. The improvement of the P. acidilactici growth in the constant fed-batch fermentation indicated the use of minimal and simple process control equipment is an effective approach for reducing by-product inhibition. Further improvement in the cultivation performance of P. acidilactici in fed-bath fermentation with in situ addition of anion-exchange resin significantly helped to enhance the growth of P. acidilactici by reducing the inhibitory effect of lactic acid and thus increasing probiotic production.

  19. Avenues and incentives for commercial use of a low-gravity environment

    NASA Technical Reports Server (NTRS)

    Brown, R. L.; Zoller, L. K.

    1981-01-01

    The scientific and commercial utilization of the low-g environments for materials research and for process and product development is considered. Any products of commercial interest which necessitate processing in space will probably be low volume, high value items. To encourage the commercialization of materials processing in low-g, NASA, in parallel with establishing and demonstrating the scientific/technological precepts for analyzing and using a low-g environment, is establishing the legal and management mechanisms to share in the cost and risk of early commercial ventures, and is now working with commercial firms on a case-by basis to explore applications of this new technology to specific needs of the company.

  20. Cryogenic applications of commercial electronic components

    NASA Astrophysics Data System (ADS)

    Buchanan, Ernest D.; Benford, Dominic J.; Forgione, Joshua B.; Harvey Moseley, S.; Wollack, Edward J.

    2012-10-01

    We have developed a range of techniques useful for constructing analog and digital circuits for operation in a liquid Helium environment (4.2 K), using commercially available low power components. The challenges encountered in designing cryogenic electronics include finding components that can function usefully in the cold and possess low enough power dissipation so as not to heat the systems they are designed to measure. From design, test, and integration perspectives it is useful for components to operate similarly at room and cryogenic temperatures; however this is not a necessity. Some of the circuits presented here have been used successfully in the MUSTANG [1] and in the GISMO [2] camera to build a complete digital to analog multiplexer (which will be referred to as the Cryogenic Address Driver board). Many of the circuit elements described are of a more general nature rather than specific to the Cryogenic Address Driver board, and were studied as a part of a more comprehensive approach to addressing a larger set of cryogenic electronic needs.

  1. Cryogenic Applications of Commercial Electronic Components

    NASA Technical Reports Server (NTRS)

    Buchanan, Ernest D.; Benford, Dominic J.; Forgione, Joshua B.; Moseley, S. Harvey; Wollack, Edward J.

    2012-01-01

    We have developed a range of techniques useful for constructing analog and digital circuits for operation in a liquid Helium environment (4.2K), using commercially available low power components. The challenges encountered in designing cryogenic electronics include finding components that can function usefully in the cold and possess low enough power dissipation so as not to heat the systems they are designed to measure. From design, test, and integration perspectives it is useful for components to operate similarly at room and cryogenic temperatures; however this is not a necessity. Some of the circuits presented here have been used successfully in the MUSTANG and in the GISMO camera to build a complete digital to analog multiplexer (which will be referred to as the Cryogenic Address Driver board). Many of the circuit elements described are of a more general nature rather than specific to the Cryogenic Address Driver board, and were studied as a part of a more comprehensive approach to addressing a larger set of cryogenic electronic needs.

  2. The criminal act of commercial surrogacy in Australia: a call for review.

    PubMed

    Stuhmcke, Anita

    2011-03-01

    Australian surrogacy legislation punishes the pursuit of a commercial surrogacy arrangement as a criminal offence. Such legislation was first introduced in Victoria in 1986 and has since been applied in every Australian jurisdiction except for the Northern Territory. The current application of criminal law is based upon this 1980s policy which has never been subject to public debate. This article argues that the continued application of criminal penalties to commercial surrogacy requires review.

  3. 76 FR 20070 - Commercial Space Transportation Safety Approval Performance Criteria

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-04-11

    ... DEPARTMENT OF TRANSPORTATION Federal Aviation Administration Commercial Space Transportation... application. Background: NASTAR applied for, and received, a safety approval for the ability of its Space... approval are applicant developed per 14 CFR 414.19 (a)(4). NASTAR's [[Page 20071

  4. Commercially developed mixed-signal CMOS process features for application in advanced ROICs in 0.18μm technology node

    NASA Astrophysics Data System (ADS)

    Kar-Roy, Arjun; Hurwitz, Paul; Mann, Richard; Qamar, Yasir; Chaudhry, Samir; Zwingman, Robert; Howard, David; Racanelli, Marco

    2012-06-01

    Increasingly complex specifications for next-generation focal plane arrays (FPAs) require smaller pixels, larger array sizes, reduced power consumption and lower cost. We have previously reported on the favorable features available in the commercially available TowerJazz CA18 0.18μm mixed-signal CMOS technology platform for advanced read-out integrated circuit (ROIC) applications. In his paper, new devices in development for commercial purposes and which may have applications in advanced ROICs are reported. First, results of buried-channel 3.3V field effect transistors (FETs) are detailed. The buried-channel pFETs show flicker (1/f) noise reductions of ~5X in comparison to surface-channel pFETs along with a significant reduction of the body constant parameter. The buried-channel nFETs show ~2X reduction of 1/f noise versus surface-channel nFETs. Additional reduced threshold voltage nFETs and pFETs are also described. Second, a high-density capacitor solution with a four-stacked linear (metal-insulator-metal) MIM capacitor having capacitance density of 8fF/μm2 is reported. Additional stacking with MOS capacitor in a 5V tolerant process results in >50fC/μm2 charge density. Finally, one-time programmable (OTP) and multi-time programmable (MTP) non-volatile memory options in the CA18 technology platform are outlined.

  5. Air-Cooled Stack Freeze Tolerance Freeze Failure Modes and Freeze Tolerance Strategies for GenDriveTM Material Handling Application Systems and Stacks Final Scientific Report

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Hancock, David, W.

    2012-02-14

    Air-cooled stack technology offers the potential for a simpler system architecture (versus liquid-cooled) for applications below 4 kilowatts. The combined cooling and cathode air allows for a reduction in part count and hence a lower cost solution. However, efficient heat rejection challenges escalate as power and ambient temperature increase. For applications in ambient temperatures below freezing, the air-cooled approach has additional challenges associated with not overcooling the fuel cell stack. The focus of this project was freeze tolerance while maintaining all other stack and system requirements. Through this project, Plug Power advanced the state of the art in technology formore » air-cooled PEM fuel cell stacks and related GenDrive material handling application fuel cell systems. This was accomplished through a collaborative work plan to improve freeze tolerance and mitigate freeze-thaw effect failure modes within innovative material handling equipment fuel cell systems designed for use in freezer forklift applications. Freeze tolerance remains an area where additional research and understanding can help fuel cells to become commercially viable. This project evaluated both stack level and system level solutions to improve fuel cell stack freeze tolerance. At this time, the most cost effective solutions are at the system level. The freeze mitigation strategies developed over the course of this project could be used to drive fuel cell commercialization. The fuel cell system studied in this project was Plug Power's commercially available GenDrive platform providing battery replacement for equipment in the material handling industry. The fuel cell stacks were Ballard's commercially available FCvelocity 9SSL (9SSL) liquid-cooled PEM fuel cell stack and FCvelocity 1020ACS (Mk1020) air-cooled PEM fuel cell stack.« less

  6. Sclerotinia homoeocarpa Overwinters in Turfgrass and Is Present in Commercial Seed

    PubMed Central

    Rioux, Renée A.; Shultz, Jeanette; Garcia, Michelle; Willis, David Kyle; Casler, Michael; Bonos, Stacy; Smith, Damon; Kerns, James

    2014-01-01

    Dollar spot is the most economically important disease of amenity turfgrasses in the United States, yet little is known about the source of primary inoculum for this disease. With the exception of a few isolates from the United Kingdom, Sclerotinia homoeocarpa, the causal agent of dollar spot, does not produce spores. Consequently, it was assumed that overwintering of this organism in soil, thatch, and plant debris provides primary inoculum for dollar spot epidemics. Overwintering of S. homoeocarpa in roots and shoots of symptomatic and asymptomatic creeping bentgrass turfgrass was quantified over the course of a three-year field experiment. Roots did not consistently harbor S. homoeocarpa, whereas S. homoeocarpa was isolated from 30% of symptomatic shoots and 10% of asymptomatic shoots in the spring of two out of three years. The presence of stroma-like pathogen material on leaf blades was associated with an increase in S. homoeocarpa isolation and colony diameter at 48 hpi. Commercial seed has also been hypothesized to be a potential source of initial inoculum for S. homoeocarpa. Two or more commercial seed lots of six creeping bentgrass cultivars were tested for contamination with S. homoeocarpa using culture-based and molecular detection methods. A viable, pathogenic isolate of S. homoeocarpa was isolated from one commercial seed lot and contamination of this lot was confirmed with nested PCR using S. homoeocarpa specific primers. A sensitive nested PCR assay detected S. homoeocarpa contamination in eight of twelve (75%) commercial seed lots. Seed source, but not cultivar or resistance to dollar spot, influenced contamination by S. homoeocarpa. Overall, this research suggests that seeds are a potential source of initial inoculum for dollar spot epidemics and presents the need for further research in this area. PMID:25333928

  7. Commercial objectives, technology transfer, and systems analysis for fusion power development

    NASA Astrophysics Data System (ADS)

    Dean, Stephen O.

    1988-03-01

    Fusion is an essentially inexhaustible source of energy that has the potential for economically attractive commercial applications with excellent safety and environmental characteristics. The primary focus for the fusion-energy development program is the generation of centralstation electricity. Fusion has the potential, however, for many other applications. The fact that a large fraction of the energy released in a DT fusion reaction is carried by high-energy neutrons suggests potentially unique applications. These include breeding of fissile fuels, production of hydrogen and other chemical products, transmutation or “burning” of various nuclear or chemical wastes, radiation processing of materials, production of radioisotopes, food preservation, medical diagnosis and medical treatment, and space power and space propulsion. In addition, fusion R&D will lead to new products and new markets. Each fusion application must meet certain standards of economic and safety and environmental attractiveness. For this reason, economics on the one hand, and safety and environment and licensing on the other hand, are the two primary criteria for setting long-range commercial fusion objectives. A major function of systems analysis is to evaluate the potential of fusion against these objectives and to help guide the fusion R&D program toward practical applications. The transfer of fusion technology and skills from the national laboratories and universities to industry is the key to achieving the long-range objective of commercial fusion applications.

  8. Environmental Dissemination of Multidrug Methicillin-Resistant Staphylococcus sciuri After Application of Manure from Commercial Swine Production Systems.

    PubMed

    Kumar, Deepak; Pornsukarom, Suchawan; Sivaraman, G K; Thakur, Siddhartha

    2018-04-01

    The deposition of manure originating from food animal farms in the environment can lead to the dissemination of antimicrobial-resistant (AMR) bacterial foodborne pathogens, thereby potentially impacting human health. The objective of our study was to determine the dissemination of multidrug methicillin-resistant Staphylococcus sciuri (MDR-MRSS) in the environment after land application of manure on commercial swine farms. A total of 400 environmental samples (40 manure and 360 soil) were collected after repeated sampling from four commercial swine farms located in North Carolina (n = 1) and Iowa (n = 3) in the United States. At each farm, we collected 10 manure and 40 soil samples (20 samples before and after 2 h of manure application) from four plots (five soil samples/plot) on day 0. Subsequently, 20 soil samples were collected on day 7, 14, and 21 from the same plots. A total of 67 (16.75%) MRSS were isolated from the 400 samples. The prevalence in soil and manure was 13.33% (48/360) and 47.5% (19/40), respectively. Prevalence was highest in the soil samples collected after 2 h of manure application on day 0 and decreased subsequently on 7, 14, and 21 days. Antimicrobial susceptibility testing was done against a panel of 12 antibiotics. A majority of S. sciuri isolates exhibited resistance against ampicillin (AMP; 95.5%), penicillin (PEN; 95.5%), clindamycin (CLI; 95.5%), cefoxitin (FOX; 92.5%), ceftiofur (XNL; 92.5%), tetracycline (TET; 86.56%), and erythromycin (ERY; 50.74%). The MDR pattern AMP FOX CLI PEN TET XNL (n = 24; 35.8%) was the most commonly observed. We detected multiple AMR genes, including mecA, aac(6'), Ie-aph(2″)Ia, tetM, tetK, mphC, ermA, ermB, and ermC. Pulsed-field gel electrophoresis clustered isolates from different sample collection days from the same farm into one group. Overall, our study identifies swine manure as an important reservoir of MDR-MRSS and highlights its dissemination in the environment upon spreading of

  9. Quantitative Detection of Viable Bifidobacterium bifidum BF-1 Cells in Human Feces by Using Propidium Monoazide and Strain-Specific Primers

    PubMed Central

    Fujimoto, Junji

    2013-01-01

    We developed a PCR-based method to detect and quantify viable Bifidobacterium bifidum BF-1 cells in human feces. This method (PMA-qPCR) uses propidium monoazide (PMA) to distinguish viable from dead cells and quantitative PCR using a BF-1-specific primer set designed from the results of randomly amplified polymorphic DNA analysis. During long-term culture (10 days), the number of viable BF-1 cells detected by counting the number of CFU on modified MRS agar, by measuring the ATP contents converted to CFU, and by using PMA-qPCR decreased from about 1010 to 106 cells/ml; in contrast, the total number of (viable and dead) BF-1 cells detected by counting 4′,6-diamidino-2-phenylindolee (DAPI)-stained cells and by using qPCR without PMA and reverse transcription-qPCR remained constant. The number of viable BF-1 cells in fecal samples detected by using PMA-qPCR was highly and significantly correlated with the number of viable BF-1 cells added to the fecal samples, within the range of 105.3 to 1010.3 cells/g feces (wet weight) (r > 0.99, P < 0.001). After 12 healthy subjects ingested 1010.3 to 1011.0 CFU of BF-1 in a fermented milk product daily for 28 days, 104.5 ± 1.5 (mean ± standard deviation [SD]) BF-1 CFU/g was detected in fecal samples by using strain-specific selective agar; in contrast, 106.2 ± 0.4 viable BF-1 cells/g were detected by using PMA-qPCR, and a total of 107.6 ± 0.7 BF-1 cells/g were detected by using qPCR without PMA. Thus, the number of viable BF-1 cells detected by PMA-qPCR was about 50 times higher (P < 0.01) than that detected by the culture-dependent method. We conclude that strain-specific PMA-qPCR can be used to quickly and accurately evaluate viable BF-1 in feces. PMID:23354719

  10. Viable twin cosmology from neutrino mixing

    NASA Astrophysics Data System (ADS)

    Csáki, Csaba; Kuflik, Eric; Lombardo, Salvator

    2017-09-01

    Twin Higgs models solve the little hierarchy problem without introducing new colored particles; however, they are often in tension with measurements of the radiation density at late times. Here we explore viable cosmological histories for twin Higgs models. In particular, we show that mixing between the Standard Model (SM) and twin neutrinos can thermalize the two sectors below the twin QCD phase transition, significantly reducing the twin sector's contribution to the radiation density. The requisite twin neutrino masses of O (1 - 20 ) GeV and mixing angle with SM neutrinos of 10-3-10-5 can be probed in a variety of current and planned experiments. We further find that these parameters can be naturally accessed in a warped UV completion, where the neutrino sector can also generate the Z2-breaking Higgs mass term needed to produce the hierarchy between the symmetry breaking scales f and v .

  11. Study of the suitability of a commercial hydroxyapatite powder to obtain sintered compacts for medical applications

    NASA Astrophysics Data System (ADS)

    Palacio, C.; Jaramillo, D.; Correa, S.; Arroyave, M.

    2017-06-01

    Hydroxyapatite (HA) is a material widely used by the medical community due to its Ca/P ratio is comparable to the Ca/P ratio of bones and teeth, which promotes osteoinduction and osteoconduction processes when in contact with bone tissue, either as volume piece or coating. This work focuses on studying the quality of the commercial HA powder MKnano-#MKN-HXAP-S12 µm, after processing, to obtain sintered compact discs with suitable physical and chemical characteristics for implants applications. The HA powder was processed through calcination, grinding, pressing and sintering to evaluate the effect of such as procedures in the compacts dics quality. The raw powder was characterized by laser diffraction, SEM, XRF, XRD, TGA and DSC while the characteristics of the obtained compact discs were determined by dilatometry and XRD to identify the sintering temperature range, constituent phases, the amorphous content and the crystallinity degree, parameters that allow determining their suitability for implants applications. Although, it was not possible to obtain sintered compacts with the suitable chemical composition and without fractures, this work allowed to identify the parameters that determine the suitability of a HA powder to obtain sintered compacts for medical applications, as well as the characterization protocol that allows the evaluation of such parameters.

  12. Monitoring of viable airborne SARS virus in ambient air

    NASA Astrophysics Data System (ADS)

    Agranovski, Igor E.; Safatov, Alexander S.; Pyankov, Oleg V.; Sergeev, Alexander N.; Agafonov, Alexander P.; Ignatiev, Georgy M.; Ryabchikova, Elena I.; Borodulin, Alexander I.; Sergeev, Artemii A.; Doerr, Hans W.; Rabenau, Holger F.; Agranovski, Victoria

    Due to recent SARS related issues (Science 300 (5624) 1394; Nature 423 (2003) 240; Science 300 (5627) 1966), the development of reliable airborne virus monitoring procedures has become galvanized by an exceptional sense of urgency and is presently in a high demand (In: Cox, C.S., Wathers, C.M. (Eds.), Bioaerosols Handbook, Lewis Publishers, Boca Raton, FL, 1995, pp. 247-267). Based on engineering control method (Aerosol Science and Technology 31 (1999) 249; 35 (2001) 852), which was previously applied to the removal of particles from gas carriers, a new personal bioaerosol sampler has been developed. Contaminated air is bubbled through porous medium submerged into liquid and subsequently split into multitude of very small bubbles. The particulates are scavenged by these bubbles, and, thus, effectively removed. The current study explores its feasibility for monitoring of viable airborne SARS virus. It was found that the natural decay of such virus in the collection fluid was around 0.75 and 1.76 lg during 2 and 4 h of continuous operation, respectively. Theoretical microbial recovery rates of higher than 55 and 19% were calculated for 1 and 2 h of operation, respectively. Thus, the new sampling method of direct non-violent collection of viable airborne SARS virus into the appropriate liquid environment was found suitable for monitoring of such stress sensitive virus.

  13. The Commercial Energy Consumer: About Whom Are We Speaking?

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Payne, Christopher

    2006-05-12

    Who are commercial sector customers, and how do they make decisions about energy consumption and energy efficiency investment? The energy policy field has not done a thorough job of describing energy consumption in the commercial sector. First, the discussion of the commercial sector itself is dominated by discussion of large businesses/buildings. Second, discussion of this portion of the commercial sectors consumption behavior is driven primarily by theory, with very little field data collected on the way commercial sector decision-makers describe their own options, choices, and reasons for taking action. These limitations artificially constrain energy policy options. This paper reviews themore » extant literature on commercial sector energy consumption behavior and identifies gaps in our knowledge. In particular, it argues that the primary energy policy model of commercial sector energy consumption is a top-down model that uses macro-level investment data to make conclusions about commercial behavior. Missing from the discussion is a model of consumption behavior that builds up to a theoretical framework informed by the micro-level data provided by commercial decision-makers themselves. Such a bottom-up model could enhance the effectiveness of commercial sector energy policy. In particular, translation of some behavioral models from the residential sector to the commercial sector may offer new opportunities for policies to change commercial energy consumption behavior. Utility bill consumption feedback is considered as one example of a policy option that may be applicable to both the residential and small commercial sector.« less

  14. Risk mitigation process for utilization of commercial off-the-shelf (COTS) parts in CCD camera for military applications

    NASA Astrophysics Data System (ADS)

    Ahmad, Anees; Batcheldor, Scott; Cannon, Steven C.; Roberts, Thomas E.

    2002-09-01

    This paper presents the lessons learned during the design and development of a high performance cooled CCD camera for military applications utilizing common commercial off the shelf (COTS) parts. Our experience showed that concurrent evaluation and testing of high risk COTS must be performed to assess their performance over the required temperature range and other special product requirements such as fuel vapor compatibility, EMI and shock susceptibility, etc. Technical, cost and schedule risks for COTS parts must also be carefully evaluated. The customer must be involved in the selection and evaluation of such parts so that the performance limitations of the selected parts are clearly understood. It is equally important to check with vendors on the availability and obsolescence of the COTS parts being considered since the electronic components are often replaced by newer, better and cheaper models in a couple of years. In summary, this paper addresses the major benefits and risks associated with using commercial and industrial parts in military products, and suggests a risk mitigation approach to ensure a smooth development phase, and predictable performance from the end product.

  15. Database tomography for commercial application

    NASA Technical Reports Server (NTRS)

    Kostoff, Ronald N.; Eberhart, Henry J.

    1994-01-01

    Database tomography is a method for extracting themes and their relationships from text. The algorithms, employed begin with word frequency and word proximity analysis and build upon these results. When the word 'database' is used, think of medical or police records, patents, journals, or papers, etc. (any text information that can be computer stored). Database tomography features a full text, user interactive technique enabling the user to identify areas of interest, establish relationships, and map trends for a deeper understanding of an area of interest. Database tomography concepts and applications have been reported in journals and presented at conferences. One important feature of the database tomography algorithm is that it can be used on a database of any size, and will facilitate the users ability to understand the volume of content therein. While employing the process to identify research opportunities it became obvious that this promising technology has potential applications for business, science, engineering, law, and academe. Examples include evaluating marketing trends, strategies, relationships and associations. Also, the database tomography process would be a powerful component in the area of competitive intelligence, national security intelligence and patent analysis. User interests and involvement cannot be overemphasized.

  16. Comparison of epifluorescent viable bacterial count methods

    NASA Technical Reports Server (NTRS)

    Rodgers, E. B.; Huff, T. L.

    1992-01-01

    Two methods, the 2-(4-Iodophenyl) 3-(4-nitrophenyl) 5-phenyltetrazolium chloride (INT) method and the direct viable count (DVC), were tested and compared for their efficiency for the determination of the viability of bacterial populations. Use of the INT method results in the formation of a dark spot within each respiring cell. The DVC method results in elongation or swelling of growing cells that are rendered incapable of cell division. Although both methods are subjective and can result in false positive results, the DVC method is best suited to analysis of waters in which the number of different types of organisms present in the same sample is assumed to be small, such as processed waters. The advantages and disadvantages of each method are discussed.

  17. NASA technology applications team: Applications of aerospace technology

    NASA Technical Reports Server (NTRS)

    1989-01-01

    Two critical aspects of the Applications Engineering Program were especially successful: commercializing products of Application Projects; and leveraging NASA funds for projects by developing cofunding from industry and other agencies. Results are presented in the following areas: the excimer laser was commercialized for clearing plaque in the arteries of patients with coronary artery disease; the ultrasound burn depth analysis technology is to be licensed and commercialized; a phased commercialization plan was submitted to NASA for the intracranial pressure monitor; the Flexible Agricultural Robotics Manipulator System (FARMS) is making progress in the development of sensors and a customized end effector for a roboticized greenhouse operation; a dual robot are controller was improved; a multisensor urodynamic pressure catherer was successful in clinical tests; commercial applications were examined for diamond like carbon coatings; further work was done on the multichannel flow cytometer; progress on the liquid airpack for fire fighters; a wind energy conversion device was tested in a low speed wind tunnel; and the Space Shuttle Thermal Protection System was reviewed.

  18. COMPARISON OF ANALYTICAL METHODS FOR THE MEASUREMENT OF NON-VIABLE BIOLOGICAL PM

    EPA Science Inventory

    The paper describes a preliminary research effort to develop a methodology for the measurement of non-viable biologically based particulate matter (PM), analyzing for mold, dust mite, and ragweed antigens and endotoxins. Using a comparison of analytical methods, the research obj...

  19. Generation of Viable Cell and Biomaterial Patterns by Laser Transfer

    NASA Astrophysics Data System (ADS)

    Ringeisen, Bradley

    2001-03-01

    In order to fabricate and interface biological systems for next generation applications such as biosensors, protein recognition microarrays, and engineered tissues, it is imperative to have a method of accurately and rapidly depositing different active biomaterials in patterns or layered structures. Ideally, the biomaterial structures would also be compatible with many different substrates including technologically relevant platforms such as electronic circuits or various detection devices. We have developed a novel laser-based technique, termed matrix assisted pulsed laser evaporation direct write (MAPLE DW), that is able to direct write patterns and three-dimensional structures of numerous biologically active species ranging from proteins and antibodies to living cells. Specifically, we have shown that MAPLE DW is capable of forming mesoscopic patterns of living prokaryotic cells (E. coli bacteria), living mammalian cells (Chinese hamster ovaries), active proteins (biotinylated bovine serum albumin, horse radish peroxidase), and antibodies specific to a variety of classes of cancer related proteins including intracellular and extracellular matrix proteins, signaling proteins, cell cycle proteins, growth factors, and growth factor receptors. In addition, patterns of viable cells and active biomolecules were deposited on different substrates including metals, semiconductors, nutrient agar, and functionalized glass slides. We will present an explanation of the laser-based transfer mechanism as well as results from our recent efforts to fabricate protein recognition microarrays and tissue-based microfluidic networks.

  20. Study of the effects of proline, phenylalanine, and urea foliar application to Tempranillo vineyards on grape amino acid content. Comparison with commercial nitrogen fertilisers.

    PubMed

    Garde-Cerdán, T; López, R; Portu, J; González-Arenzana, L; López-Alfaro, I; Santamaría, P

    2014-11-15

    The aim of this work was to study the influence of foliar application of different nitrogen sources on grape amino acid content. The nitrogen sources applied to Tempranillo grapevines were proline, phenylalanine, urea, and two commercial nitrogen fertilisers, both without and with amino acids in their formulations. All treatments were applied at veraison and one week later. Proline treatment did not affect the must nitrogen composition. However, phenylalanine and urea foliar application enhanced the plants' synthesis of most of the amino acids, producing similar effects. In addition, the spray of commercial nitrogen fertilisers over leaves also induced a rise in grape amino acid concentrations regardless of the presence or absence of amino acids in their formulation. The most effective treatments were phenylalanine and urea followed by nitrogen fertilisers. This finding is of oenological interest for improved must nitrogen composition, ensuring better fermentation kinetics and most likely enhancing wine quality. Copyright © 2014 Elsevier Ltd. All rights reserved.

  1. Commercialization of biopharmaceutical knowledge in Iran; challenges and solutions

    PubMed Central

    2014-01-01

    Background The objective of this study was to investigate the application of the university research findings or commercialization of the biopharmaceutical knowledge in Iran and determine the challenges and propose some solutions. Results A qualitative study including 19 in-depth interviews with experts was performed in 2011 and early 2012. National Innovation System (NIS) model was employed as the study design. Thematic method was applied for the analysis. The results demonstrate that policy making, regulations and management development are considered as fundamental reasons for current commercialization practice pattern. It is suggested to establish foundation for higher level documents that would involve relating bodies and provide them operational guidelines for the implementation of commercialization incentives. Conclusions Policy, regulations and management as the most influential issue should be considered for successful commercialization. The present study, for the first time, attempts to disclose the importance of evidence input for measures in order to facilitate the commercialization process by the authorities in Iran. Overall, the NIS model should be considered and utilized as one of the effective solutions for commercialization. PMID:24568555

  2. A new class of monolithic seismometers and accelerometers for commercial and industrial applications: the UNISA folded pendulum

    NASA Astrophysics Data System (ADS)

    Barone, F.; Giordano, G.

    2017-04-01

    In this paper we present monolithic implementations of tunable mechanical seismometers and accelerometers (horizontal, vertical and angular) based on the UNISA Folded Pendulum configuration, protected by three international patents and commercially available. Typical characteristics are measurement band 10-7 / 1kHz, sensitivity down to ≍ 10-15 m/ √ Hz, directivity > 104, weight < 1.5 kg, dimensions < 10 cm, coupled to a large insensitivity to environmental noises and capability of operating in ultra high vacuum and cryogenic environments. Typical applications of this class of sensors are in the field of earthquake engineering, seismology, geophysics, civil engineering (buildings, bridges, dams, etc.), space (inertial guide).

  3. 10 CFR 431.92 - Definitions concerning commercial air conditioners and heat pumps.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... expressed in identical units of measurement. Commercial package air-conditioning and heating equipment means... application. Computer Room Air Conditioner means a basic model of commercial package air-conditioning and heating equipment (packaged or split) that is: Used in computer rooms, data processing rooms, or other...

  4. Application of genotypic and phenotypic analyses to commercial probiotic strain identity and relatedness.

    PubMed

    Yeung, P S M; Kitts, C L; Cano, R; Tong, P S; Sanders, M E

    2004-01-01

    The objective of this study was to generate strain-specific genomic patterns of a bank of 67 commercial and reference probiotic strains, with a focus on probiotic lactobacilli. Pulsed-field gel electrophoresis (PFGE) was used as the primary method for strain differentiation. This method was compared with carbohydrate fermentation analysis. To supplement visual comparison, PFGE patterns were analysed quantitatively by cluster analysis using unweighted pair group method with arithmetic averages. SmaI, NotI and XbaI were found to effectively generate clear and easy-to-interpret PFGE patterns of a range of probiotic strains. Some probiotic strains from different sources shared highly similar PFGE patterns. Results document the value of genotypic strain identification methods, combined with phenotypic methods, for determining probiotic strain identity and relatedness. No correlation was found between relatedness determined by carbohydrate fermentation profiles alone compared with PFGE analysis alone. Some commercial strains are probably derived from similar sources. This approach is valuable to the probiotic industry to develop commercial strain identification patterns, to provide quality control of strain manufacturing production runs, to track use of protected strains and to determine the relatedness among different research and commercial probiotic strains.

  5. METHIONINE UPTAKE AND CYTOPATHOGENICITY OF VIABLE BUT NONCULTURABLE SHIGELLA DYSENTERIAE TYPE 1

    EPA Science Inventory

    A pathogenic strain of Shigella dysenteriae Type 1 was selected for study to elucidate the physiology and potential pathogenicity of organisms In the viable but nonculturable (VBNC) state In the environment. tudies in our laboratory have shown that S. dysenteriae Type 1 survives ...

  6. Commercial scale research and assessment of poultry welfare.

    PubMed

    Dawkins, Marian Stamp

    2012-01-01

    1. Commercial level research on poultry welfare is increasingly important because of the insight it gives into what improves welfare in the context of other important drivers such as human health, environmental impact and cost. 2. There are, however, a number of problems with conducting commercial level research - such as conflicts over aims, financial compensation and legal issues - that need to be addressed if the gains from commercial research are to be optimized. Cooperation between all parties and mutual understanding of the different priorities that may exist between industry and academia are essential. 3. Three important developments for the future are: the setting up of a 'data bank', the application of new statistical methods for analyzing data and new technology for assessing welfare automatically.

  7. Viable spore counts in biological controls pre-sterilization.

    PubMed

    Brusca, María I; Bernat, María I; Turcot, Liliana; Nastri, Natalia; Nastri, Maria; Rosa, Alcira

    2005-01-01

    The aim of the present study was to evaluate the total count of viable spores in standardized inoculated carriers pre-sterilization. Samples of "Bacterial Spore Sterilization Strip" (R Biological Laboratories) (well before their expiry date) were divided into Group A (B. subtilis) and Group B (B. stearothermophylus). Twenty-four strips were tested per group. The strips were minced in groups of three, placed in chilled sterile water and vortexed for 5 minutes to obtain a homogenous suspension. Ten ml of the homogenous suspension were transferred to two sterile jars, i.e. one jar per group. The samples were then heated in a water bath at 95 degrees C (Group A) or 80 degrees C (Group B) for 15 minutes and cooled rapidly in an ice bath at 0- 4 degrees C during 15 minutes. Successive dilutions were performed until a final aliquot of 30 to 300 colony-forming units (CFU) was obtained. The inoculums were placed in Petri dishes with culture medium (soy extract, casein agar adapted for spores, melted and cooled to 45-50 degrees C) and incubated at 55 degrees C or 37 degrees C. Statistical analysis of the data was performed. A larger number of spores were found at 48 hours than at 24 hours. However, this finding did not hold true for all the groups. The present results show that monitoring viable spores pre-sterilization would guarantee the accuracy of the data. Total spore counts must be within 50 and 300% of the number of spores indicated in the biological control. The procedure is essential to guarantee the efficacy of the biological control.

  8. Commercial lumber

    Treesearch

    Kent A. McDonald; David E. Kretschmann

    1999-01-01

    In a broad sense, commercial lumber is any lumber that is bought or sold in the normal channels of commerce. Commercial lumber may be found in a variety of forms, species, and types, and in various commercial establishments, both wholesale and retail. Most commercial lumber is graded by standardized rules that make purchasing more or less uniform throughout the country...

  9. Solar/UV-induced photocatalytic degradation of three commercial textile dyes.

    PubMed

    Neppolian, B; Choi, H C; Sakthivel, S; Arabindoo, Banumathi; Murugesan, V

    2002-01-28

    The photocatalytic degradation of three commercial textile dyes with different structure has been investigated using TiO(2) (Degussa P25) photocatalyst in aqueous solution under solar irradiation. Experiments were conducted to optimise various parameters viz. amount of catalyst, concentration of dye, pH and solar light intensity. Degradation of all the dyes were examined by using chemical oxygen demand (COD) method. The degradation efficiency of the three dyes is as follows: Reactive Yellow 17(RY17) > Reactive Red 2(RR2) > Reactive Blue 4 (RB4), respectively. The experimental results indicate that TiO(2) (Degussa P25) is the best catalyst in comparison with other commercial photocatalysts such as, TiO(2) (Merck), ZnO, ZrO(2), WO(3) and CdS. Though the UV irradiation can efficiently degrade the dyes, naturally abundant solar irradiation is also very effective in the mineralisation of dyes. The comparison between thin-film coating and aqueous slurry method reveals that slurry method is more efficient than coating but the problems of leaching and the requirement of separation can be avoided by using coating technique. These observations indicate that all the three dyes could be degraded completely at different time intervals. Hence, it may be a viable technique for the safe disposal of textile wastewater into the water streams.

  10. Serum miRNA Predicts Viable Disease after Chemotherapy in Patients with Testicular Nonseminoma Germ Cell Tumor.

    PubMed

    Leão, Ricardo; van Agthoven, Ton; Figueiredo, Arnaldo; Jewett, Michael A S; Fadaak, Kamel; Sweet, Joan; Ahmad, Ardalan E; Anson-Cartwright, Lynn; Chung, Peter; Hansen, Aaron; Warde, Padraig; Castelo-Branco, Pedro; O'Malley, Martin; Bedard, Philippe L; Looijenga, Leendert H J; Hamilton, Robert J

    2018-02-21

    Retroperitoneal lymph node dissection is recommended for residual masses greater than 1 cm after chemotherapy of nonseminomatous germ cell tumors. Currently to our knowledge there is no reliable predictor of post-chemotherapy retroperitoneal lymph node dissection histology. Up to 50% of patients harbor necrosis/fibrosis only so that a potentially morbid surgery has limited therapeutic value. In this study we evaluated the ability of defined serum miRNAs to predict residual viable nonseminomatous germ cell tumors after chemotherapy. Levels of serum miRNA, including miR-371a-3p, miR-373-3p and miR-367-3p, were measured using the ampTSmiR (amplification targeted serum miRNA) test in 82 patients, including 39 in cohort 1 and 43 in cohort 2, who were treated with orchiectomy, chemotherapy and post-chemotherapy retroperitoneal lymph node dissection. miRNA levels were compared to clinical characteristics and serum tumor markers. They correlated with the presence of a viable germ cell tumor vs fibrosis/necrosis and teratoma. ROC analysis was done to determine miRNA discriminative capacity. miRNA levels were significantly associated with disease extent at chemotherapy and they decreased significantly after chemotherapy. Conventional serum tumor maker levels were uninformative after chemotherapy. However, after chemotherapy miRNA levels remained elevated in post-chemotherapy retroperitoneal lymph node dissection specimens of patients harboring viable germ cell tumors. miR-371a-3p demonstrated the highest discriminative capacity for viable germ cell tumors (AUC 0.874, 95% CI 0.774-0.974, p <0.0001). Using an adapted hypothetical cutoff of 3 cm or less for surgical intervention miR-371a-3p correctly stratified all patients with viable residual retroperitoneal germ cell tumors with 100% sensitivity (p = 0.02). To our knowledge our study demonstrates for the first time the potential value of miR-371a-3p to predict viable germ cell tumors in residual masses after chemotherapy

  11. Quantitative detection of viable helminth ova from raw wastewater, human feces, and environmental soil samples using novel PMA-qPCR methods.

    PubMed

    Gyawali, P; Ahmed, W; Sidhu, J P S; Nery, S V; Clements, A C; Traub, R; McCarthy, J S; Llewellyn, S; Jagals, P; Toze, S

    2016-09-01

    In this study, we have evaluated the efficacy of propidium monoazide quantitative polymerase chain reaction (PMA-qPCR) to differentiate between viable and non-viable Ancylostoma caninum ova. The newly developed method was validated using raw wastewater seeded with known numbers of A. caninum ova. Results of this study confirmed that PMA-qPCR has resulted in average of 88 % reduction (P < 0.05) in gene copy numbers for 50 % viable +50 % non-viable when compared with 100 % viable ova. A reduction of 100 % in gene copies was observed for 100 % non-viable ova when compared with 100 % viable ova. Similar reductions (79-80 %) in gene copies were observed for A. caninum ova-seeded raw wastewater samples (n = 18) collected from wastewater treatment plants (WWTPs) A and B. The newly developed PMA-qPCR method was applied to determine the viable ova of different helminths (A. caninum, A. duodenale, Necator americanus and Ascaris lumbricoides) in raw wastewater, human fecal and soil samples. None of the unseeded wastewater samples were positive for the above-mentioned helminths. N. americanus and A. lumbricoides ova were found in unseeded human fecal and soil samples. For the unseeded human fecal samples (1 g), an average gene copy concentration obtained from qPCR and PMA-qPCR was found to be similar (6.8 × 10(5) ± 6.4 × 10(5) and 6.3 × 10(5) ± 4.7 × 10(5)) indicating the presence of viable N. americanus ova. Among the 24 unseeded soil samples tested, only one was positive for A. lumbricoides. The mean gene copy concentration in the positively identified soil sample was 1.0 × 10(5) ± 1.5 × 10(4) (determined by qPCR) compared to 4.9 × 10(4) ± 3.7 × 10(3) (determined by PMA-qPCR). The newly developed PMA-qPCR methods were able to detect viable helminth ova from wastewater and soil samples and could be adapted for health risk assessment.

  12. 19 CFR 113.67 - Commercial gauger and commercial laboratory bond conditions.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 19 Customs Duties 1 2010-04-01 2010-04-01 false Commercial gauger and commercial laboratory bond... SECURITY; DEPARTMENT OF THE TREASURY CUSTOMS BONDS Customs Bond Conditions § 113.67 Commercial gauger and commercial laboratory bond conditions. Commercial Gauger Bond Conditions (a) Commercial gauger bond...

  13. Assessing the Impact of Manure Application in Commercial Swine Farms on the Transmission of Antimicrobial Resistant Salmonella in the Environment.

    PubMed

    Pornsukarom, Suchawan; Thakur, Siddhartha

    2016-01-01

    Land application of swine manure in commercial hog farms is an integral part of their waste management system which recycles the nutrients back to the soil. However, manure application can lead to the dissemination of bacterial pathogens in the environment and pose a serious public health threat. The aim of this study was to determine the dissemination of antimicrobial resistant Salmonella in the environment due to manure application in commercial swine farms in North Carolina (n = 6) and Iowa (n = 7), two leading pork producing states in the US. We collected manure and soil samples twice on day 0 (before and after manure application) from four distinct plots of lands (5 soil samples/plot) located at 20 feet away from each other in the field. Subsequent soil samples were collected again on days 7, 14, 21 from the same plots. A total of 1,300 soil samples (NC = 600; IA = 700) and 130 manure samples (NC = 60; IA = 70) were collected and analyzed in this study. The overall Salmonella prevalence was 13.22% (189/1,430), represented by 10.69% and 38.46% prevalence in soil and manure, respectively. The prevalence in NC (25.45%) was significantly higher than in IA (2.73%) (P<0.001) and a consistent decrease in Salmonella prevalence was detected from Day 0-Day 21 in all the farms that tested positive. Salmonella serotypes detected in NC were not detected in IA, thereby highlighting serotype association based on manure storage and soil application method used in the two regions. Antimicrobial susceptibility testing was done by the broth microdilution method to a panel of 15 antimicrobial drugs. A high frequency of isolates (58.73%) were multidrug resistant (resistance to three or more class of antimicrobials) and the most frequent resistance was detected against streptomycin (88.36%), sulfisoxazole (67.2%), and tetracycline (57.67%). Genotypic characterization by pulse field gel electrophoresis revealed clonally related Salmonella in both manure and soil at multiple time

  14. Assessing the Impact of Manure Application in Commercial Swine Farms on the Transmission of Antimicrobial Resistant Salmonella in the Environment

    PubMed Central

    Pornsukarom, Suchawan; Thakur, Siddhartha

    2016-01-01

    Land application of swine manure in commercial hog farms is an integral part of their waste management system which recycles the nutrients back to the soil. However, manure application can lead to the dissemination of bacterial pathogens in the environment and pose a serious public health threat. The aim of this study was to determine the dissemination of antimicrobial resistant Salmonella in the environment due to manure application in commercial swine farms in North Carolina (n = 6) and Iowa (n = 7), two leading pork producing states in the US. We collected manure and soil samples twice on day 0 (before and after manure application) from four distinct plots of lands (5 soil samples/plot) located at 20 feet away from each other in the field. Subsequent soil samples were collected again on days 7, 14, 21 from the same plots. A total of 1,300 soil samples (NC = 600; IA = 700) and 130 manure samples (NC = 60; IA = 70) were collected and analyzed in this study. The overall Salmonella prevalence was 13.22% (189/1,430), represented by 10.69% and 38.46% prevalence in soil and manure, respectively. The prevalence in NC (25.45%) was significantly higher than in IA (2.73%) (P<0.001) and a consistent decrease in Salmonella prevalence was detected from Day 0-Day 21 in all the farms that tested positive. Salmonella serotypes detected in NC were not detected in IA, thereby highlighting serotype association based on manure storage and soil application method used in the two regions. Antimicrobial susceptibility testing was done by the broth microdilution method to a panel of 15 antimicrobial drugs. A high frequency of isolates (58.73%) were multidrug resistant (resistance to three or more class of antimicrobials) and the most frequent resistance was detected against streptomycin (88.36%), sulfisoxazole (67.2%), and tetracycline (57.67%). Genotypic characterization by pulse field gel electrophoresis revealed clonally related Salmonella in both manure and soil at multiple time

  15. Biocatalytic Synthesis of the Rare Sugar Kojibiose: Process Scale-Up and Application Testing.

    PubMed

    Beerens, Koen; De Winter, Karel; Van de Walle, Davy; Grootaert, Charlotte; Kamiloglu, Senem; Miclotte, Lisa; Van de Wiele, Tom; Van Camp, John; Dewettinck, Koen; Desmet, Tom

    2017-07-26

    Cost-efficient (bio)chemical production processes are essential to evaluate the commercial and industrial applications of promising carbohydrates and also are essential to ensure economically viable production processes. Here, the synthesis of the naturally occurring disaccharide kojibiose (2-O-α-d-glucopyranosyl-d-glucopyranoside) was evaluated using different Bifidobacterium adolescentis sucrose phosphorylase variants. Variant L341I_Q345S was found to efficiently synthesize kojibiose while remaining fully active after 1 week of incubation at 55 °C. Process optimization allowed kojibiose production at the kilogram scale, and simple but efficient downstream processing, using a yeast treatment and crystallization, resulted in more than 3 kg of highly pure crystalline kojibiose (99.8%). These amounts allowed a deeper characterization of its potential in food applications. It was found to have possible beneficial health effects, including delayed glucose release and potential to trigger SCFA production. Finally, we compared the bulk functionality of highly pure kojibiose to that of sucrose, hereby mapping its potential as a new sweetener in confectionery products.

  16. A commercial application of fire retardants to dry-formed hardboards

    Treesearch

    Gary C. Meyers; Carlton A. Holmes

    1977-01-01

    Based on laboratory performance with a number of fire-retardant chemicals, disodium octaborate tetrahydrate-boric acid and dicyandiamide-phosphoric acid-formaldehyde were selected for treating fiber and making 4 foot by 8-foot dry-formed hardboards on a commercial production line. The boards were evaluated for performance under exposure to fire, strength, dimensional...

  17. Status of commercial fuel cell powerplant system development

    NASA Technical Reports Server (NTRS)

    Warshay, Marvin

    1987-01-01

    The primary focus is on the development of commercial Phosphoric Acid Fuel Cell (PAFC) powerplant systems because the PAFC, which has undergone extensive development, is currently the closest fuel cell system to commercialization. Shorter discussions are included on the high temperature fuel cell systems which are not as mature in their development, such as the Molten Carbonate Fuel Cell (MCFC) and the Solid Oxide Fuel Cell (SOFC). The alkaline and the Solid Polymer Electrolyte (SPE) fuel cell systems, are also included, but their discussions are limited to their prospects for commercial development. Currently, although the alkaline fuel cell continues to be used for important space applications there are no commercial development programs of significant size in the USA and only small efforts outside. The market place for fuel cells and the status of fuel cell programs in the USA receive extensive treatment. The fuel cell efforts outside the USA, especially the large Japanese programs, are also discussed.

  18. The Potential Uses of Commercial Satellite Imagery in the Middle East

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Vannoni, M.G.

    1999-06-08

    It became clear during the workshop that the applicability of commercial satellite imagery to the verification of future regional arms control agreements is limited at this time. Non-traditional security topics such as environmental protection, natural resource management, and the development of infrastructure offer the more promising applications for commercial satellite imagery in the short-term. Many problems and opportunities in these topics are regional, or at least multilateral, in nature. A further advantage is that, unlike arms control and nonproliferation applications, cooperative use of imagery in these topics can be done independently of the formal Middle East Peace Process. The valuemore » of commercial satellite imagery to regional arms control and nonproliferation, however, will increase during the next three years as new, more capable satellite systems are launched. Aerial imagery, such as that used in the Open Skies Treaty, can also make significant contributions to both traditional and non-traditional security applications but has the disadvantage of requiring access to national airspace and potentially higher cost. There was general consensus that commercial satellite imagery is under-utilized in the Middle East and resources for remote sensing, both human and institutional, are limited. This relative scarcity, however, provides a natural motivation for collaboration in non-traditional security topics. Collaborations between scientists, businesses, universities, and non-governmental organizations can work at the grass-roots level and yield contributions to confidence building as well as scientific and economic results. Joint analysis projects would benefit the region as well as establish precedents for cooperation.« less

  19. Viable inflationary evolution from Einstein frame loop quantum cosmology

    NASA Astrophysics Data System (ADS)

    de Haro, Jaume; Odintsov, S. D.; Oikonomou, V. K.

    2018-04-01

    In this work we construct a bottom-up reconstruction technique for loop quantum cosmology scalar-tensor theories, from the observational indices. Particularly, the reconstruction technique is based on fixing the functional form of the scalar-to-tensor ratio as a function of the e -foldings number. The aim of the technique is to realize viable inflationary scenarios, and the only assumption that must hold true in order for the reconstruction technique to work is that the dynamical evolution of the scalar field obeys the slow-roll conditions. We use two functional forms for the scalar-to-tensor ratio, one of which corresponds to a popular inflationary class of models, the α attractors. For the latter, we calculate the leading order behavior of the spectral index and we demonstrate that the resulting inflationary theory is viable and compatible with the latest Planck and BICEP2/Keck-Array data. In addition, we find the classical limit of the theory, and as we demonstrate, the loop quantum cosmology corrected theory and the classical theory are identical at leading order in the perturbative expansion quantified by the parameter ρc, which is the critical density of the quantum theory. Finally, by using the formalism of slow-roll scalar-tensor loop quantum cosmology, we investigate how several inflationary potentials can be realized by the quantum theory, and we calculate directly the slow-roll indices and the corresponding observational indices. In addition, the f (R ) gravity frame picture is presented.

  20. Reexamining the minimum viable population concept for long-lived species.

    PubMed

    Shoemaker, Kevin T; Breisch, Alvin R; Jaycox, Jesse W; Gibbs, James P

    2013-06-01

    For decades conservation biologists have proposed general rules of thumb for minimum viable population size (MVP); typically, they range from hundreds to thousands of individuals. These rules have shifted conservation resources away from small and fragmented populations. We examined whether iteroparous, long-lived species might constitute an exception to general MVP guidelines. On the basis of results from a 10-year capture-recapture study in eastern New York (U.S.A.), we developed a comprehensive demographic model for the globally threatened bog turtle (Glyptemys muhlenbergii), which is designated as endangered by the IUCN in 2011. We assessed population viability across a wide range of initial abundances and carrying capacities. Not accounting for inbreeding, our results suggest that bog turtle colonies with as few as 15 breeding females have >90% probability of persisting for >100 years, provided vital rates and environmental variance remain at currently estimated levels. On the basis of our results, we suggest that MVP thresholds may be 1-2 orders of magnitude too high for many long-lived organisms. Consequently, protection of small and fragmented populations may constitute a viable conservation option for such species, especially in a regional or metapopulation context. © 2013 Society for Conservation Biology.

  1. Changes in total viable count and TVB-N content in marinated chicken breast fillets during storage

    NASA Astrophysics Data System (ADS)

    Baltić, T.; Ćirić, J.; Velebit, B.; Petronijević, R.; Lakićević, B.; Đorđević, V.; Janković, V.

    2017-09-01

    Marination is a popular technique for enhancing meat properties. Depending on the marinade type and ingredients added, marination can improve sensory, chemical and microbiological quality of meat products. In this study, the total viable count and total volatile basic nitrogen (TVB-N) content in marinated chicken breast fillets were investigated. The possible correlation between bacterial growth and formation of TVB-N was also tested. Chicken breast fillets were immersed in a solution of table salt (as a control) orthree different marinades,which consisted of table salt, sodium tripolyphosphate and/or sodium citrate, and stored in air for nine days at 4±1°C. Analyses of the total viable count and TVB-N were performed on days0, 3, 6 and 9 day of storage. The total viable count gradually increased in all examined groups, and statistically significant differences (p<0.01 p<0.05) between treatments on days0, 3 and 6 day of storage were established. TVB-N values in marinated chicken were significantly higher (p<0.01 p<0.05) compared to the control. Using the multiple linear regression, a positive correlation between total viable count and formation of TVB-N in chicken marinated with sodium citrate was established (p<0.05), while the intensity of TVB-N formation was lowest in chicken marinated with sodium tripolyphosphate.

  2. U.S. commercial space activities - Returning the U.S. to preeminence in space

    NASA Technical Reports Server (NTRS)

    Stone, Barbara A.

    1987-01-01

    The current status of NASA's activities related to the commercial development of space is reviewed with particular reference to the emerging new commercial space activities and the post-Challenger policy developments affecting space commerce. The discussion covers the development of U.S. private sector launching capabilities, cooperative agreements with the private sector, the NASA technology utilization program, the technology applications activities of the Office of Commercial Programs, and the activities of the Centers for the Commercial Development of Space program.

  3. Proprietary rights and commercial use of space stations

    NASA Technical Reports Server (NTRS)

    Kempf, Robert F.

    1986-01-01

    The treatment of proprietary rights related to commercial activity aboard an international space station is discussed, with a focus on the relationship between the acquisition (on earth or in space) and protection of such rights. The applicable national and international law is briefly characterized, and consideration is given to patent, trade-secret, and copyright considerations. It is concluded that the provisions of present commercial law can be applied relatively straightforwardly to rights acquired on earth, while the Outer Space Treaty of 1967 and the Convention on Registration of 1976 apply to rights obtained in space.

  4. Seasonal and spatial distribution of bacterial biomass and the percentage of viable cells in a reservoir of Alabama

    USGS Publications Warehouse

    Tietjen, T.E.; Wetzel, R.G.

    2003-01-01

    Spatial community dynamics of bacterioplankton were evaluated along the length of the former stream channel of Elledge Lake, a small reservoir in western Alabama. The reservoir was strongly stratified from April to October with up to a 10??C temperature difference across the 1 m deep metalimnion. Bacterial biomass was highest during late summer, with a general pattern of increasing abundance from the inflowing river (???10 ??g C l-1) to the dam (???20-30 ??g C l-1). Bacterial numbers also increased following a >10-fold increase in turbidity associated with a major precipitation event, although only ???10% of these cells were viable. The percentage of viable cells generally increased through the stratified period with 50-70% viable cells in late summer. Overall, an average of 38% of bacterial cells were viable, with a range from <20 to 70%. Although these values were similar to those found by others, additional patterns were identified that have not been previously observed: a marked decline in viable cells was found following turbid storm inflows and increases in the percentage of viable cells occurred during spring warming and following autumnal mixing events. Although a modest increase in abundance occurred along the gradient from inflow down-reservoir to the dam, bacterial abundance did not increase near the dam in a pattern coincident with the commonly observed increased algal biomass in the lacustrine portion of reservoir ecosystems. The increases observed in bacterial viability moving from the inflowing rivers towards the dam and later in stratified periods stress the importance of differences in environmental conditions in time and space in regulating bacterial biomass and development, as well as of shifts that would be anticipated accompanying altered hydrological regimes under climatic change.

  5. Advanced Analysis to Distinguish between Physical Decrease and Inactivation of Viable Phages in Aerosol by Quantitating Phage-Specific Particles.

    PubMed

    Shimasaki, Noriko; Nojima, Yasuhiro; Sakakibara, Masaya; Kikuno, Ritsuko; Iizuka, Chiori; Okaue, Akira; Okuda, Shunji; Shinohara, Katsuaki

    2018-01-01

     Recent studies have investigated the efficacy of air-cleaning products against pathogens in the air. A standard method to evaluate the reduction in airborne viruses caused by an air cleaner has been established using a safe bacteriophage instead of pathogenic viruses; the reduction in airborne viruses is determined by counting the number of viable airborne phages by culture, after operating the air cleaner. The reduction in the number of viable airborne phages could be because of "physical decrease" or "inactivation". Therefore, to understand the mechanism of reduction correctly, an analysis is required to distinguish between physical decrease and inactivation. The purpose of this study was to design an analysis to distinguish between the physical decrease and inactivation of viable phi-X174 phages in aerosols. We established a suitable polymerase chain reaction (PCR) system by selecting an appropriate primer-probe set for PCR and validating the sensitivity, linearity, and specificity of the primer-probe set to robustly quantify phi-X174-specific airborne particles. Using this quantitative PCR system and culture assay, we performed a behavior analysis of the phage aerosol in a small chamber (1 m 3 ) at different levels of humidity, as humidity is known to affect the number of viable airborne phages. The results revealed that the reduction in the number of viable airborne phages was caused not only by physical decrease but also by inactivation under particular levels of humidity. Our study could provide an advanced analysis to differentiate between the physical decrease and inactivation of viable airborne phages.

  6. Estimating commercial property prices: an application of cokriging with housing prices as ancillary information

    NASA Astrophysics Data System (ADS)

    Montero-Lorenzo, José-María; Larraz-Iribas, Beatriz; Páez, Antonio

    2009-12-01

    A vast majority of the recent literature on spatial hedonic analysis has been concerned with residential property values, with only very few examples of studies focused on commercial property prices. The dearth of studies can be attributed to some of the challenges faced in the analysis of commercial properties, in particular the scarcity of information compared to residential transactions. In order to address this issue, in this paper we propose the use of cokriging and housing prices as ancillary information to estimate commercial property prices. Cokriging takes into account the spatial autocorrelation structure of property prices, and the use of more abundant information on housing prices helps to improve the accuracy of property value estimates. A case study of Toledo in Spain, a city for which commercial activity stemming from tourism is one of the key elements of the economy in the city, demonstrates that substantial accuracy and precision gains can be obtained from the use of cokriging.

  7. Application of commercial aircraft accident investigation techniques to a railroad derailment.

    DOT National Transportation Integrated Search

    1973-01-01

    Crash investigation techniques utilized by human factors teams in investigating commercial airline crashes have been applied in the analysis of a railroad train derailment - crash. Passengers in cars that remained upright experienced very low deceler...

  8. Reduced infectivity of waterborne viable but nonculturable Helicobacter pylori strain SS1 in mice.

    PubMed

    Boehnke, Kevin F; Eaton, Kathryn A; Fontaine, Clinton; Brewster, Rebecca; Wu, Jianfeng; Eisenberg, Joseph N S; Valdivieso, Manuel; Baker, Laurence H; Xi, Chuanwu

    2017-08-01

    Helicobacter pylori infection has been consistently associated with lack of access to clean water and proper sanitation, but no studies have demonstrated that the transmission of viable but nonculturable (VBNC) H. pylori can occur from drinking contaminated water. In this study, we used a laboratory mouse model to test whether waterborne VBNCH. pylori could cause gastric infection. We performed five mouse experiments to assess the infectivity of VBNCH. pylori in various exposure scenarios. VBNC viability was examined using Live/Dead staining and Biolog phenotype metabolism arrays. High doses of VBNCH. pylori in water were chosen to test the "worst-case" scenario for different periods of time. One experiment also investigated the infectious capabilities of VBNC SS1 using gavage. Further, immunocompromised mice were exposed to examine infectivity among potentially vulnerable groups. After exposure, mice were euthanized and their stomachs were examined for H. pylori infection using culture and PCR methodology. VBNC cells were membrane intact and retained metabolic activity. Mice exposed to VBNCH. pylori via drinking water and gavage were not infected, despite the various exposure scenarios (immunocompromised, high doses) that might have permitted infection with VBNCH. pylori. The positive controls exposed to viable, culturable H. pylori did become infected. While other studies that have used viable, culturable SS1 via gavage or drinking water exposures to successfully infect mice, in our study, waterborne VBNC SS1 failed to colonize mice under all test conditions. Future studies could examine different H. pylori strains in similar exposure scenarios to compare the relative infectivity of the VBNC vs the viable, culturable state, which would help inform future risk assessments of H. pylori in water. © 2017 The Authors. Helicobacter Published by John Wiley & Sons Ltd.

  9. Viable myocardium scintigraphy with intravenous nitroglycerine by computed tomography with Tc-99m (MIBI).

    PubMed

    Ramos Filho, José; Nascimento, Marcos Welber; Silva, Rafael Mariano Gislon da; Camargo, Thiago Negrini de; Almeida, Roberto Simões de; Lima, Eloá Jacinto

    2008-09-01

    The selection of patients with chronic coronary disease for recanalization is based on the detection of the affected myocardium that is potentially viable. To evaluate the potentially viable ischemic myocardium through single photon emission computed tomography (SPECT) with MIBI after a maximum tolerated dose of I.V. nitroglycerin. We prospectively investigated by SPECT with Tc-99m (MIBI), from April 2004 to November 2005, 40 patients (mean age: 62 +/- 8.9 yrs, 30 men) with coronary obstruction demonstrated angiographically; the myocardium scintigraphy was carried out at rest and after intravenous (I.V.) nitroglycerin, which was started at a dose of 1 microg/kg/min and increased every minute until the systolic blood pressure decreased by 20 mmHg. The decrease in the perfusion of the segments was classified as moderate or severe and compared after the nitroglycerin. The angiographic, hemodynamic and myocardial perfusion variables were analyzed. We analyzed 680 myocardial segments at rest: 538 with a homogenous distribution and 142 with hypoperfusion (54 with moderate and 88 with severe decrease). After the nitroglycerin, there was an increase in the perfusion in 19 (47.5%) of 40 patients and 55 of 142 segments became viable: 33 (61.1%) with moderate and 22 (25%) with severe decrease; both presented a significant increase in the radiotracer distribution (p < 0.001, Chi-square). One of the components with Tc-99m is Tc-99m 2-methoxy-isobutyl-isonitrile (MIBI), which, when used with an optimized dose of I.V. nitroglycerin, can increase the radiotracer uptake in areas with moderate and severe hypoperfusion. The results of the present study suggest the increase in the Tc-99m (MIBI) sensitivity by nitroglycerin for the detection of viable myocardium.

  10. Use of commercial grade item dedication to reduce procurement costs

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Rosch, F.

    1995-09-01

    In the mid-1980s, the Nuclear Regulatory Industry (NRC) began inspecting utility practices of procuring and dedicating commercial grade items intended for plant safety-related applications. As a result of the industry efforts to address NRC concerns, nuclear utilities have enhanced existing programs and procedures for dedication of commercial grade items. Though these programs were originally enhanced to meet NRC concerns, utilities have discovered that the dedication of commercial grade items can also reduce overall procurement costs. This paper will discuss the enhancement of utility dedication programs and demonstrates how utilities have utilized them to reduce procurement costs.

  11. Wood energy-commercial applications

    NASA Technical Reports Server (NTRS)

    Kennel, R. P.

    1978-01-01

    Wood energy is being widely investigated in many areas of the country because of the many obvious benefits of wood fuel such as the low price per million Btus relative to coal, oil, and gas; the wide availability of noncommercial wood and the proven ability to harvest it; established technology which is reliable and free of pollution; renewable resources; better conservation for harvested land; and the potential for jobs creation. The Southeastern United States has a specific leadership role in wood energy based on its established forest products industry experience and the potential application of wood energy to other industries and institutions. Significant questions about the widespread usage of wood energy are being answered in demonstrations around the country as well as the Southeast in areas of wood storage and bulk handling; high capitalization costs for harvesting and combustion equipment; long term supply and demand contracts; and the economic feasibility of wood energy outside the forest products industry.

  12. Total biosynthesis of deoxynucleoside triphosphates using deoxynucleoside monophosphate kinases for PCR application.

    PubMed

    Bao, Jie; Ryu, Dewey D Y

    2007-09-01

    Polymerase chain reaction (PCR) and other PCR applications for DNA synthesis require deoxynucleoside triphosphates (dNTP) as the essential precursors and substrates. Currently, the dNTP is commercially produced by a chemical method which is environmentally hazardous and costly due to its low yields in both the synthetic reaction and purification processes. In this study, a enzyme technology for the total integrated biosynthesis of all dNTP components is presented. The bioprocess technology developed and reported here involves two sequential enzymatic phosphorylation reactions coupled with the cofactor regeneration starting from deoxynucleoside monophosphates (dNMP) to deoxynucleoside diphosphates (dNDP) in the first reaction step and to dNTP in the second reaction step in the same bioreactor. The four genes encoding these deoxynucleoside monophosphate kinases were cloned into the recombinant E. coli and expressed using the recombinant E. coli strains. The reaction mechanisms and kinetics of the four kinase enzymes are studied and reported. The total enzymatic syntheses of the four dNTP products were carried out in four separate operations under the high substrate concentrations which emulate the practical application. The optimal process conditions were carefully investigated and complete conversion of dNMP to dNTP at high substrate concentration have been achieved. The purity and quality of dNTP products obtained from this work were analyzed and found to be at least equivalent or better than the commercially available dNTP products. The PCR application of dNTP products obtained from this work were also evaluated for isolating and amplifying genes of different sizes from different organisms. The PCR performance test also showed an equivalent quality as compared to the commercially available dNTP. The bioprocess technology developed and reported here for production of dNTP will provide economically competitive and environmentally friendly viable technology for the

  13. PossybliCom, a Commercially Viable Personal Navigator for Blind People

    NASA Astrophysics Data System (ADS)

    Bavaro, M.; Citterico, D.; Dionisio, C.; van Eijck, D.

    2007-08-01

    Disaps vof is a Dutch start-up Company which is born as spin-off from the Italian company Intecs S.p.A.. Disaps is working on a project called PossybliCom, which is the acronym of Positioning System for Blind, and it is developing wearable navigation equipment for visually impaired or in general people withself- localization problems. Other secondary markets could be thought of as well, such as peoplesuffering from Alzheimer or having temporary memory or consciousness losses. Even peoplehaving experienced problems like TIA (Transient Ischemic Attacks) or faints would need a highlyaccessible device knowing always the way home. PossybliCom is a contribution to further enhance these users' confidence in independent travelling by providing them with a more precise description of the surroundings they are in. A business feasibility study demonstrated how, under certain key restrictions on the system architecture,the product has a high potential for disabled people as well as for the others when specialenvironmental conditions apply. Main issues could be easily identified as accessibility, portability, ease of use, fast learning curve. The European Space Agency's business incubation facility ESI in Noordwijk is supporting the start-up project with physical incubation, which includes office space and shared facilities as well as access to services and the know-how of ESA staff. Once part of the business incubation programme, for aperiod of 6 months the company shall demonstrate the market feasibility and produce a detailed workplan for prototyping.

  14. Commercial integration and partnering at Savannah River Site

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Steele, J.R.; Babione, R.A.; Shikashio, L.A.

    1994-06-01

    Savannah River Site (SRS), particularly the Savannah River Technology Center (SRTC) with the experience from the first successful Integrated Technology Demonstration, can provide an excellent foundation for meeting DOE-EM`s objectives with the new DOE-EM five focus area approach. With this in mind, SRTC established an activity to pursue full commercialization of environmental technologies. This report is an assessment of the status of commercialization at SRS and provides recommendations for enhancement as well as some tools critical to implementation. A review was made of the current situation at SRS with regards to taking technology development to commercial fruition. This was donemore » from the perspective of comparing it to known commercialization models and processes. It was found that SRTC already works through many of the steps in these processes. With integration and action-oriented efforts of the inclusion of business and market factors, SRTC could become an aggressive, successful developer of commercialized technologies. Commercial success criteria tools were developed with regards to integrating them with SRTC selection criteria to ensure that all critical factors are covered in technology commercialization project evaluations. Private investors are very clear that their interest lies in funding commercial enterprises, not merely technologies. Mobilizing private capital is critical to real job growth and long-term economic development. Also, potential industry partners were identified that are willing to be involved with SRS` technology applications and regional development efforts. As another important component to success, regional support organizations were reviewed and evaluated.« less

  15. Fundamentals and commercial aspects of nanobiosensors in point-of-care clinical diagnostics.

    PubMed

    Mahato, Kuldeep; Maurya, Pawan Kumar; Chandra, Pranjal

    2018-03-01

    Among various problems faced by mankind, health-related concerns are prevailing since long which are commonly found in the form of infectious diseases and different metabolic disorders. The clinical cure and management of such abnormalities are greatly dependent on the availability of their diagnoses. The conventional diagnostics used for such purposes are extremely powerful; however, most of these are limited by time-consuming protocols and require higher volume of test sample, etc. A new evolving technology called "biosensor" in this context shows an enormous potential for an alternative diagnostic device, which constantly compliments the conventional diagnoses. In this review, we have summarized different kinds of biosensors and their fundamental understanding with various state-of-the-art examples. A critical examination of different types of biosensing mechanisms is also reported highlighting the advantages of electrochemical biosensors for its great potentials in next-generation commercially viable modules. In recent years, a number of nanomaterials are extensively used to enhance not only the performance of biosensing mechanism, but also obtain robust, cheap, and fabrication-friendly durable mechanism. Herein, we have summarized the importance of nanomaterials in biosensing mechanism, their syntheses as well as characterization techniques. Subsequently, we have discussed the probe fabrication processes along with various techniques for assessing its analytical performances and potentials for commercial viability.

  16. Proceedings of the 2004 High Spatial Resolution Commercial Imagery Workshop

    NASA Technical Reports Server (NTRS)

    2006-01-01

    Topics covered include: NASA Applied Sciences Program; USGS Land Remote Sensing: Overview; QuickBird System Status and Product Overview; ORBIMAGE Overview; IKONOS 2004 Calibration and Validation Status; OrbView-3 Spatial Characterization; On-Orbit Modulation Transfer Function (MTF) Measurement of QuickBird; Spatial Resolution Characterization for QuickBird Image Products 2003-2004 Season; Image Quality Evaluation of QuickBird Super Resolution and Revisit of IKONOS: Civil and Commercial Application Project (CCAP); On-Orbit System MTF Measurement; QuickBird Post Launch Geopositional Characterization Update; OrbView-3 Geometric Calibration and Geopositional Accuracy; Geopositional Statistical Methods; QuickBird and OrbView-3 Geopositional Accuracy Assessment; Initial On-Orbit Spatial Resolution Characterization of OrbView-3 Panchromatic Images; Laboratory Measurement of Bidirectional Reflectance of Radiometric Tarps; Stennis Space Center Verification and Validation Capabilities; Joint Agency Commercial Imagery Evaluation (JACIE) Team; Adjacency Effects in High Resolution Imagery; Effect of Pulse Width vs. GSD on MTF Estimation; Camera and Sensor Calibration at the USGS; QuickBird Geometric Verification; Comparison of MODTRAN to Heritage-based Results in Vicarious Calibration at University of Arizona; Using Remotely Sensed Imagery to Determine Impervious Surface in Sioux Falls, South Dakota; Estimating Sub-Pixel Proportions of Sagebrush with a Regression Tree; How Do YOU Use the National Land Cover Dataset?; The National Map Hazards Data Distribution System; Recording a Troubled World; What Does This-Have to Do with This?; When Can a Picture Save a Thousand Homes?; InSAR Studies of Alaska Volcanoes; Earth Observing-1 (EO-1) Data Products; Improving Access to the USGS Aerial Film Collections: High Resolution Scanners; Improving Access to the USGS Aerial Film Collections: Phoenix Digitizing System Product Distribution; System and Product Characterization: Issues Approach

  17. Commercial potential of remote sensing data from the Earth observing system

    NASA Technical Reports Server (NTRS)

    Merry, Carolyn J.; Tomlin, Sandra M.

    1992-01-01

    The purpose was to assess the market potential of remote sensing value-added products from the Earth Observing System (EOS) platform. Sensors on the EOS platform were evaluated to determine which qualities and capabilities could be useful to the commercial user. The approach was to investigate past and future satellite data distribution programs. A questionnaire was developed for use in a telephone survey. Based on the results of the survey of companies that add value to remotely sensed data, conversations with the principal investigators in charge of each EOS sensor, a study of past commercial satellite data ventures, and reading from the commercial remote sensing industry literature, three recommendations were developed: develop a strategic plan for commercialization of EOS data, define a procedure for commercial users within the EOS data stream, and develop an Earth Observations Commercial Applications Program-like demonstration program within NASA using EOS simulated data.

  18. Natural environmental water sources in endemic regions of northeastern Brazil are potential reservoirs of viable Mycobacterium leprae.

    PubMed

    Arraes, Maria Luisa Bezerra de Macedo; Holanda, Maísa Viana de; Lima, Luana Nepomuceno Gondim Costa; Sabadia, José Antônio Beltrão; Duarte, Cynthia Romariz; Almeida, Rosa Livia Freitas; Kendall, Carl; Kerr, Ligia Regina Sansigolo; Frota, Cristiane Cunha

    2017-12-01

    The detection of live Mycobacterium leprae in soil and animals other than humans suggests that the environment plays a role in the transmission of leprosy. The objective of this study was to investigate the presence of viable M. leprae in natural water sources used by the local population in five municipalities in the state of Ceará, northeastern Brazil. Samples were collected from 30 different sources. Viable bacilli were identified by reverse transcriptase polymerase chain reaction (PCR) of the M. leprae gyrA gene and sequencing of the PCR products. Physicochemical properties of each water source were also assessed. M. leprae gyrA mRNA was found in 23 (76.7%) of the water sources. No association was found between depth of the water and sample positivity, nor was there any association between the type of water used by the population and sample positivity. An association between viable M. leprae and temperature and pH was found. Georeferencing showed a relation between the residences of leprosy cases and water source containing the bacterium. The finding of viable M. leprae in natural water sources associated with human contact suggests that the environment plays an important role in maintaining endemic leprosy in the study region.

  19. Senior health clinics: are they financially viable?

    PubMed

    McAtee, Robin E; Crandall, Debra; Wright, Larry D; Beverly, Claudia J

    2009-07-01

    Are hospital-based outpatient interdisciplinary clinics a financially viable alternative for caring for our burgeoning population of older adults in America? Although highly popular, with high patient satisfaction rates among older adults and their families, senior health clinics (SHCs) can be expensive to operate, with limited quantifiable health outcomes. This study analyzed three geriatric hospital-based interdisciplinary clinics in rural Arkansas by examining their patient profiles, revenues, and expenses. It closely examined the effects of the downstream revenue using the multiplier effect and acknowledged other factors that weigh heavily on the success of SHCs and the care of older adults. The findings highlight the similarities and differences in the three clinics' operating and financial structures in addition to the clinics' and providers' productivity. The analysis presents an evidence-based illustration that SHCs can break even or lose large amounts of money.

  20. Health Information Technologies-Academic and Commercial Evaluation (HIT-ACE) methodology: description and application to clinical feedback systems.

    PubMed

    Lyon, Aaron R; Lewis, Cara C; Melvin, Abigail; Boyd, Meredith; Nicodimos, Semret; Liu, Freda F; Jungbluth, Nathaniel

    2016-09-22

    Health information technologies (HIT) have become nearly ubiquitous in the contemporary healthcare landscape, but information about HIT development, functionality, and implementation readiness is frequently siloed. Theory-driven methods of compiling, evaluating, and integrating information from the academic and commercial sectors are necessary to guide stakeholder decision-making surrounding HIT adoption and to develop pragmatic HIT research agendas. This article presents the Health Information Technologies-Academic and Commercial Evaluation (HIT-ACE) methodology, a structured, theory-driven method for compiling and evaluating information from multiple sectors. As an example demonstration of the methodology, we apply HIT-ACE to mental and behavioral health measurement feedback systems (MFS). MFS are a specific class of HIT that support the implementation of routine outcome monitoring, an evidence-based practice. HIT-ACE is guided by theories and frameworks related to user-centered design and implementation science. The methodology involves four phases: (1) coding academic and commercial materials, (2) developer/purveyor interviews, (3) linking putative implementation mechanisms to hit capabilities, and (4) experimental testing of capabilities and mechanisms. In the current demonstration, phase 1 included a systematic process to identify MFS in mental and behavioral health using academic literature and commercial websites. Using user-centered design, implementation science, and feedback frameworks, the HIT-ACE coding system was developed, piloted, and used to review each identified system for the presence of 38 capabilities and 18 additional characteristics via a consensus coding process. Bibliometic data were also collected to examine the representation of the systems in the scientific literature. As an example, results are presented for the application of HIT-ACE phase 1 to MFS wherein 49 separate MFS were identified, reflecting a diverse array of characteristics

  1. Soft Robotics Commercialization: Jamming Grippers from Research to Product

    PubMed Central

    Cheng, Nadia; Fakhouri, Sami; Culley, Bill

    2016-01-01

    Abstract Recent work in the growing field of soft robotics has demonstrated a number of very promising technologies. However, to make a significant impact in real-world applications, these new technologies must first transition out of the laboratory through successful commercialization. Commercialization is perhaps the most critical future milestone facing the field of soft robotics today, and this process will reveal whether the apparent impact we now perceive has been appropriately estimated. Since 2012, Empire Robotics has been one of the first companies to attempt to reach this milestone through our efforts to commercialize jamming-based robotic gripper technology in a product called VERSABALL®. However, in spring 2016 we are closing our doors, having not been able to develop a sustainable business around this technology. This article presents some of the key takeaways from the technical side of the commercialization process and lessons learned that may be valuable to others. We hope that sharing this information will provide a frame of reference for technology commercialization that can help others motivate research directions and maximize research impact. PMID:28078197

  2. Ability of bed bug-detecting canines to locate live bed bugs and viable bed bug eggs.

    PubMed

    Pfiester, Margie; Koehler, Philip G; Pereira, Roberto M

    2008-08-01

    The bed bug, Cimex lectularius L., like other bed bug species, is difficult to visually locate because it is cryptic. Detector dogs are useful for locating bed bugs because they use olfaction rather than vision. Dogs were trained to detect the bed bug (as few as one adult male or female) and viable bed bug eggs (five, collected 5-6 d after feeding) by using a modified food and verbal reward system. Their efficacy was tested with bed bugs and viable bed bug eggs placed in vented polyvinyl chloride containers. Dogs were able to discriminate bed bugs from Camponotus floridanus Buckley, Blattella germanica (L.), and Reticulitermes flavipes (Kollar), with a 97.5% positive indication rate (correct indication of bed bugs when present) and 0% false positives (incorrect indication of bed bugs when not present). Dogs also were able to discriminate live bed bugs and viable bed bug eggs from dead bed bugs, cast skins, and feces, with a 95% positive indication rate and a 3% false positive rate on bed bug feces. In a controlled experiment in hotel rooms, dogs were 98% accurate in locating live bed bugs. A pseudoscent prepared from pentane extraction of bed bugs was recognized by trained dogs as bed bug scent (100% indication). The pseudoscent could be used to facilitate detector dog training and quality assurance programs. If trained properly, dogs can be used effectively to locate live bed bugs and viable bed bug eggs.

  3. Two-aged silvicultural treatments in lodgepole pine stands can be economically viable

    Treesearch

    Ward W. McCaughey; Steven J. Martin; Dean A. Blomquist

    2006-01-01

    Economically viable silvicultural options are critical for management activities that provide wood products, reduce forest fuels, improve forest health, and enhance wildlife habitat. The Tenderfoot Research Project was developed in the late 1990s to evaluate and quantify ecological and biological effects of two-aged silvicultural treatments including prescribed fire in...

  4. Quantifying viable Vibrio parahaemolyticus and Listeria monocytogenes simultaneously in raw shrimp.

    PubMed

    Zhang, Zhaohuan; Liu, Haiquan; Lou, Yang; Xiao, Lili; Liao, Chao; Malakar, Pradeep K; Pan, Yingjie; Zhao, Yong

    2015-08-01

    A novel TaqMan-based multiplex real-time PCR method combined with propidium monoazide (PMA) treatment was firstly developed for the simultaneous quantification of viable Vibrio parahaemolyticus and Listeria monocytogenes in raw shrimp. The optimization of PMA concentration showed that 100 μM was considered optimal to effectively inhibit 10(8) CFU/mL dead cells of both bacteria. The high specificity of this method was confirmed on tests using 96 target and non-target strains. The optimized assay could detect as low as 10(1)-10(2) CFU/g of each strain on the artificially contaminated shrimp, and its amplification efficiencies were up to 100 and 106 % for V. parahaemolyticus and L. monocytogenes, respectively. Furthermore, this assay has been successfully applied to describe the behavior of these two pathogens in raw shrimps stored at 4 °C. In conclusion, this PMA TaqMan-based multiplex real-time PCR technique, where the whole procedure takes less than 5 h, provides an effective and rapid tool for monitoring contamination of viable V. parahaemolyticus and L. monocytogenes in seafood, improving seafood safety and protecting public health.

  5. Iowa Commercial Pesticide Applicator Manual, Category 11: Aerial Applicators. CS-26.

    ERIC Educational Resources Information Center

    DeWitt, Jerald R., Ed.

    This manual provides information needed to meet specific standards for certification as a pesticide applicator. The text is concerned with the calibration and application of pesticides/herbicides by aircraft. Special attention is given to the field flight patterns and safety precautions which must be considered for the pilot, ground crews and the…

  6. A multicenter study of viable PCR using propidium monoazide to detect Legionella in water samples.

    PubMed

    Scaturro, Maria; Fontana, Stefano; Dell'eva, Italo; Helfer, Fabrizia; Marchio, Michele; Stefanetti, Maria Vittoria; Cavallaro, Mario; Miglietta, Marilena; Montagna, Maria Teresa; De Giglio, Osvalda; Cuna, Teresa; Chetti, Leonarda; Sabattini, Maria Antonietta Bucci; Carlotti, Michela; Viggiani, Mariagabriella; Stenico, Alberta; Romanin, Elisa; Bonanni, Emma; Ottaviano, Claudio; Franzin, Laura; Avanzini, Claudio; Demarie, Valerio; Corbella, Marta; Cambieri, Patrizia; Marone, Piero; Rota, Maria Cristina; Bella, Antonino; Ricci, Maria Luisa

    2016-07-01

    Legionella quantification in environmental samples is overestimated by qPCR. Combination with a viable dye, such as Propidium monoazide (PMA), could make qPCR (named then vPCR) very reliable. In this multicentre study 717 artificial water samples, spiked with fixed concentrations of Legionella and interfering bacterial flora, were analysed by qPCR, vPCR and culture and data were compared by statistical analysis. A heat-treatment at 55 °C for 10 minutes was also performed to obtain viable and not-viable bacteria. When data of vPCR were compared with those of culture and qPCR, statistical analysis showed significant differences (P < 0.001). However, although the heat-treatment caused an abatement of CFU/mL ≤1 to 1 log10 unit, the comparison between untreated and heat-treated samples analysed by vPCR highlighted non-significant differences (P > 0.05). Overall this study provided a good experimental reproducibility of vPCR but also highlighted limits of PMA in the discriminating capability of dead and live bacteria, making vPCR not completely reliable. Copyright © 2016 Elsevier Inc. All rights reserved.

  7. Economically viable biochemical processes for the advanced rural biorefinery and downstream recovery operations

    USDA-ARS?s Scientific Manuscript database

    Rural biorefineries offer an alternative to traditional ethanol production by providing the opportunity to produce fuel on site to reduce costs associated with biomass transportation thus making the fuel economically viable. Widespread installation of rural biorefineries could lead to increased upt...

  8. Direct viable count as test for toxicity assessment: the effects of four metals on a Salmonella enteritidis strain.

    PubMed

    Scoglio, M E; Di Pietro, A; Anzalone, C; Calimeri, S; Lo Giudice, D; Trimarchi, G R

    2000-01-01

    The toxicity of synthetic sewage containing increasing concentrations of arsenic (.125, .25, .5, 1.0 mg L-1), cadmium (.02, .05, .1, .2 mg L-1), lead (.2, .5, 1.0, 2.0 mg L-1) and nickel (.5, 1.0, 2.0, 4.0 mg L-1) has been investigated by determining the total direct count (TDC) and the direct viable count (DVC) of Salmonella enteritidis by means of an immunofluorescence technique (IFA). This has been done in order to evaluate the possibility of using the IFA technique to estimate the toxicity of complex effluents. Arsenic, cadmium and nickel produced a concentration-dependent reduction in the number of viable bacterial cells. This was more clear when the viable bacterial cells were considered than when only the culturable part was used. Lead did not show a concentration-dependent and reproducible effect. At the highest concentrations allowed by the Italian wastewater regulations, lead, cadmium, arsenic and nickel reduced the viable/total bacterial cells ratio to 74.5%, 68.5%, 28.4% and 6.9%, respectively. The toxic effects of the metals were also tested using the standard Microtox assay.

  9. Protein Engineering: Case Studies of Commercialized Engineered Products

    ERIC Educational Resources Information Center

    Walsh, Gary

    2007-01-01

    Programs in biochemistry invariably encompass the principles of protein engineering. Students often display increased understanding and enthusiasm when theoretical concepts are underpinned by practical example. Herein are presented five case studies, each focusing upon a commercial protein product engineered to enhance its application-relevant…

  10. Moving research to patient applications through commercialization: understanding and evaluating the role of intellectual property.

    PubMed

    Patino, Robert M

    2010-03-01

    The advancement of research from discovery to the delivery of medical care can be limited without the support of industry to sponsor its continued development. Federal government financial support is generally crucial in early-stage development through funding from the NIH, National Science Foundation, and other federal agencies; however, government support generally stops shortly after basic research discoveries have been reported. Much of the cessation of financial support derives from the government's regulatory responsibilities, as sponsoring the commercialization of a product conflicts with regulation of the approval for clinical use of a drug or device. Furthermore, differences in goals, resources, and flexibility render government, as compared with private industry, inefficient and less responsive to market demands with regard to stream-lining the development of and enhancing the quality of products and services offered. Thus, industry and private investment provide the bridge that converts new discoveries into healthcare products that are available to consumers and patients. This conversion occurs through commercialization, which involves both high risks and high rewards. Taking advantage of the commercialization option for research development requires an understanding of the technology transfer process. This article reviews 5 topics: 1) industry motivation to invest in academic research; 2) institutional considerations in partnering with industry; 3) academia's interactions with inventors in the commercialization process; 4) the research institution's route to commercialization, and 5) the role of intellectual property and commercialization in the advancement of healthcare.

  11. Moving Research to Patient Applications through Commercialization: Understanding and Evaluating the Role of Intellectual Property

    PubMed Central

    2010-01-01

    The advancement of research from discovery to the delivery of medical care can be limited without the support of industry to sponsor its continued development. Federal government financial support is generally crucial in early-stage development through funding from the NIH, National Science Foundation, and other federal agencies; however, government support generally stops shortly after basic research discoveries have been reported. Much of the cessation of financial support derives from the government's regulatory responsibilities, as sponsoring the commercialization of a product conflicts with regulation of the approval for clinical use of a drug or device. Furthermore, differences in goals, resources, and flexibility render government, as compared with private industry, inefficient and less responsive to market demands with regard to stream-lining the development of and enhancing the quality of products and services offered. Thus, industry and private investment provide the bridge that converts new discoveries into healthcare products that are available to consumers and patients. This conversion occurs through commercialization, which involves both high risks and high rewards. Taking advantage of the commercialization option for research development requires an understanding of the technology transfer process. This article reviews 5 topics: 1) industry motivation to invest in academic research; 2) institutional considerations in partnering with industry; 3) academia's interactions with inventors in the commercialization process; 4) the research institution's route to commercialization, and 5) the role of intellectual property and commercialization in the advancement of healthcare. PMID:20353687

  12. Space Station Workshop: Commercial Missions and User Requirements

    NASA Technical Reports Server (NTRS)

    1988-01-01

    The topics of discussion addressed during a three day workshop on commercial application in space are presented. Approximately half of the program was directed towards an overview and orientation to the Space Station Project; the technical attributes of space; and present and future potential commercial opportunities. The remaining time was spent addressing technological issues presented by previously-formed industry working groups, who attempted to identify the technology needs, problems or issues faced and/or anticipated by the following industries: extraction (mining, agriculture, petroleum, fishing, etc.); fabrication (manufacturing, automotive, aircraft, chemical, pharmaceutical and electronics); and services (communications, transportation and retail robotics). After the industry groups presented their technology issues, the workshop divided into smaller discussion groups composed of: space experts from NASA; academia; industry experts in the appropriate disciplines; and other workshop participants. The needs identified by the industry working groups, space station technical requirements, proposed commercial ventures and other issues related to space commercialization were discussed. The material summarized and reported are the consensus from the discussion groups.

  13. 7 CFR 1942.111 - Applicant eligibility.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... applicant apply to commercial sources for financing. To provide a basis for referral of only those applicants who may be able to finance projects through commercial sources, approval officials should maintain... must determine whether financing from commercial sources at reasonable rates and terms is available. If...

  14. Enabling Sustainable Exploration through the Commercial Development of Space

    NASA Technical Reports Server (NTRS)

    Nall, Mark; Casas, Joseph

    2003-01-01

    The commercial development of space offers enabling benefits to space exploration. This paper examines how those benefits can be realized, and how the Space Product Development Office of the National Aeronautics and Space Administration is taking the first steps towards opening the space frontier through vital and sustainable industrial development. The Space Product Development Office manages 15 Commercial Space Centers that partner with US industry to develop opportunities for commerce in space. This partnership directly benefits NASA exploration in four primary ways. First, by actively involving traditional and non-traditional companies in commercial space activities, it seeks and encourages to the maximum extent possible the fullest commercial use of space, as directed by NASA's charter. Second, the commercial research and technologies pursued and developed in the program often have direct applicability to NASA priority mission areas. This dual use strategy for research and technology has the potential to greatly expand what the NASA scientific community can do. Third, the commercial experiment hardware developed by the Commercial Space Centers and their industrial partners is available for use by NASA researchers in support of priority NASA research. By utilizing low cost and existing commercial hardware, essential NASA research can be more readily accomplished. Fourth, by assisting industry in understanding the use of the environment of space and in helping industry enhance the tools and technologies for NASA and commercial space systems, the market for commercial space utilization and the capability for meeting the future growing market needs is being developed. These two activities taken together form the beginning of a new space economy that will enable sustainable NASA exploration of the universe.

  15. Horizontal Dissemination of Antimicrobial Resistance Determinants in Multiple Salmonella Serotypes following Isolation from the Commercial Swine Operation Environment after Manure Application.

    PubMed

    Pornsukarom, Suchawan; Thakur, Siddhartha

    2017-10-15

    The aim of this study was to characterize the plasmids carrying antimicrobial resistance (AMR) determinants in multiple Salmonella serotypes recovered from the commercial swine farm environment after manure application on land. Manure and soil samples were collected on day 0 before and after manure application on six farms in North Carolina, and sequential soil samples were recollected on days 7, 14, and 21 from the same plots. All environmental samples were processed for Salmonella , and their plasmid contents were further characterized. A total of 14 isolates including Salmonella enterica serotypes Johannesburg ( n = 2), Ohio ( n = 2), Rissen ( n = 1), Typhimurium var5- ( n = 5), Worthington ( n = 3), and 4,12:i:- ( n = 1), representing different farms, were selected for plasmid analysis. Antimicrobial susceptibility testing was done by broth microdilution against a panel of 14 antimicrobials on the 14 confirmed transconjugants after conjugation assays. The plasmids were isolated by modified alkaline lysis, and PCRs were performed on purified plasmid DNA to identify the AMR determinants and the plasmid replicon types. The plasmids were sequenced for further analysis and to compare profiles and create phylogenetic trees. A class 1 integron with an ANT(2″)-Ia- aadA2 cassette was detected in the 50-kb IncN plasmids identified in S Worthington isolates. We identified 100-kb and 90-kb IncI1 plasmids in S Johannesburg and S Rissen isolates carrying the bla CMY-2 and tet (A) genes, respectively. An identical 95-kb IncF plasmid was widely disseminated among the different serotypes and across different farms. Our study provides evidence on the importance of horizontal dissemination of resistance determinants through plasmids of multiple Salmonella serotypes distributed across commercial swine farms after manure application. IMPORTANCE The horizontal gene transfer of antimicrobial resistance (AMR) determinants located on plasmids is considered to be the main reason for

  16. The design of a commercial space infrastructure

    NASA Technical Reports Server (NTRS)

    1989-01-01

    Space Services and Logistics, Inc. represents the complete engineering design of a technically and financially viable commercial space company. The final proposal offers an economically sound program of space vehicles and systems designed to substantially affect a variety of space markets and produce a vertically integrated structure within the next 20 years. Throughout this design process, particular stress has been placed on attaining the highest possible levels of safety and reliability. The final program financial design requires a considerable initial outlay, but promises a relatively quick return on invested capital, culminating in large annual profits by the end of the 20-year scope of the cost outlook. The overall design has been extensively researched and was primarily driven by the present and near-term projected market demands for services uniquely or competitively offered only by space-oriented operations. Heretofore, available capabilities, rather than these market demands, have determined the degree and type of commercial market access. Removing this limitation through extensive use of modularity and reconfigurability allows the company to gear itself to the market, while still remaining extremely competitive with existing systems. The markets identified as lucrative, and that have governed much of the design requirements, are: low-cost launch services to LEO over a wide range of payload masses and inclinations; upper stage payload delivery from LEO to GEO; manned space operations and human transport to and from orbit; EVA assembly and maintenance of large space structures; satellite servicing and repair by both humans and telerobotic operations; a line of customized satellites designed for extended life and capable of reconfiguration or technology upgrade on orbit; small-scale microgravity experimentation and manufacturing supported by spacecraft retrieval capabilities for experimental specimens and manufactured goods; and a full-range of payload

  17. Enterocolic lymphocytic phlebitis: statistical analysis of histology features in viable and ischemic bowel.

    PubMed

    Medlicott, Shaun A C; Guggisberg, Kelly A; DesCôteaux, Jean-Gaston; Beck, Paul

    2006-07-01

    Enterocolic lymphocytic phlebitis is a rare cause of segmental ischemic enterocolitis. This artery-sparing transmural vasculitis is classically a circumferential phlebitis with perivenular lymphocyte cuffing and thrombi in the absence of systemic manifestations. Myointimal hyperplasia may represent a chronic phase of enterocolic lymphocytic phlebitis. Subclinical or early stage enterocolic lymphocytic phlebitis is not well delineated. We analyzed 600 submucosal and subserosal veins from both ischemic and intact bowel segments to discern if vascular morphology varied between sites. Crescentic and circumferential lymphocytic phlebitis is more common in viable bowel than in the ischemic segment. A nonsignificant trend was found for increased crescentic morphology between intact bowel remote from the ischemic focus compared with that adjacent to the ischemic focus. Hallmarks of ischemic bowel are necrotizing phlebitis and thrombi formation. Thrombophlebitis morphology is distinctly different in viable and ischemic bowel, changing from the classic lymphocytic to necrotizing lesions respectively.

  18. The New Anechoic Shielded Chambers Designed for Space and Commercial Applications at LIT

    NASA Technical Reports Server (NTRS)

    da Silva, Benjamim; Galvao, M. C.; Pereira, Clovis Solano

    2008-01-01

    The main objective of this paper is to present the capabilities of the new anechoic shielded rooms designed for space and commercial applications as part of the Integration and Testing Laboratory (LIT, Laboratorio de Integracao e Testes) in Brazil. A new anechoic shielded room named CBA2 has been in full operation since March 2007 and a remodeled chamber CBA1 is planned to be ready by the end of 2008, replacing an old facility which was in operation for the last 18 years. The Brazilian Space Program started with very small and simple satellites and the old CBA1 chamber was conceived in 1987 to accomplish the EMI/EMC tests not requiring significant volumes. Since the very beginning this facility was also used by the private sector for other applications mainly due to the absorption of digital electronics in all kind of products. The intense use of this facility during the last years, operating three shifts a day, caused a normal degradation and imposed several limitations. Therefore, a new totally remodeled chamber was designed considering the state of the art in terms of absorbers and associated instrumentation. On the other hand the facility CBA2 was conceived, designed and implemented to test large satellites taking into account the advance of the technology in terms of RF frequencies, power level, testing methodologies and several other factors. A very interesting and unique aspect of this project was the partnership between the private sector and governmental institution. As a result, the total investment was shared between several companies and consequently a time-sharing use of the facility as well.

  19. Method for procuring specific populations of viable human prostate cells for research.

    PubMed

    Fischer, A H; Philips, A; Taysavang, P; McKenney, J K; Amin, M B

    2001-04-01

    A wider range of research can be conducted on viable tissue samples than on fixed or frozen samples. A major obstacle to studying viable prostate tissue samples is the inability to accurately identify cancer on direct examination of unembedded tissue. We used a dissecting microscope to identify cancer in unfixed prostate tissue samples stained on the cut surface with 0.5% aqueous toluidine blue. We measured the diagnostic accuracy of this technique in 25 consecutive prostatectomies, determined the viability of procured samples, and estimated the effect on final pathologic assessment. Both surfaces of a 3- to 5-mm thick cross-section taken midway between base and apex of the prostate were examined. A 4-mm punch biopsy was directed to one benign and one malignant area when clearly present. The dissecting microscope allowed clearcut recognition of carcinoma in 17 of the 25 cross-sections, and carcinoma was confirmed in all 17 (100%). In 8 of 25 cases, no procurement was attempted because no carcinoma was evident in the one cross-section studied. Twenty of 25 cross-sections were adequate for benign tissue procurement; five of the cross-sections were not suitable for procurement because of the presence of extensive carcinoma or atrophy. Seventeen of the 20 were accurately diagnosed as benign (85%); one showed pseudohyperplastic adenocarcinoma, one showed focal high-grade prostatic intraepithelial neoplasia, and one showed urothelial carcinoma in situ. Prostatic epithelium obtained with the technique remains viable and can be separated from stroma. The dissecting microscope technique appears to facilitate rather than interfere with accurate pathologic assessment: extraprostatic extension or positive margins were correctly identified during tissue procurement in three cases. The procedure takes only about 30 minutes.

  20. Finding viable models in SUSY parameter spaces with signal specific discovery potential

    NASA Astrophysics Data System (ADS)

    Burgess, Thomas; Lindroos, Jan Øye; Lipniacka, Anna; Sandaker, Heidi

    2013-08-01

    Recent results from ATLAS giving a Higgs mass of 125.5 GeV, further constrain already highly constrained supersymmetric models such as pMSSM or CMSSM/mSUGRA. As a consequence, finding potentially discoverable and non-excluded regions of model parameter space is becoming increasingly difficult. Several groups have invested large effort in studying the consequences of Higgs mass bounds, upper limits on rare B-meson decays, and limits on relic dark matter density on constrained models, aiming at predicting superpartner masses, and establishing likelihood of SUSY models compared to that of the Standard Model vis-á-vis experimental data. In this paper a framework for efficient search for discoverable, non-excluded regions of different SUSY spaces giving specific experimental signature of interest is presented. The method employs an improved Markov Chain Monte Carlo (MCMC) scheme exploiting an iteratively updated likelihood function to guide search for viable models. Existing experimental and theoretical bounds as well as the LHC discovery potential are taken into account. This includes recent bounds on relic dark matter density, the Higgs sector and rare B-mesons decays. A clustering algorithm is applied to classify selected models according to expected phenomenology enabling automated choice of experimental benchmarks and regions to be used for optimizing searches. The aim is to provide experimentalist with a viable tool helping to target experimental signatures to search for, once a class of models of interest is established. As an example a search for viable CMSSM models with τ-lepton signatures observable with the 2012 LHC data set is presented. In the search 105209 unique models were probed. From these, ten reference benchmark points covering different ranges of phenomenological observables at the LHC were selected.