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Sample records for virtual library electronic

  1. Commuting from Electronic Cottage to Virtual Library.

    ERIC Educational Resources Information Center

    Woodward, Jeannette

    1996-01-01

    Although telecommuting has been found to increase productivity and morale in business environments, libraries rarely consider it. This article discusses telecommuting's potential impact on contact with users, length of employment, job descriptions, budgets, management style, communication, and workflow. This option may help libraries retain older…

  2. Commuting from Electronic Cottage to Virtual Library.

    ERIC Educational Resources Information Center

    Woodward, Jeannette

    1996-01-01

    Although telecommuting has been found to increase productivity and morale in business environments, libraries rarely consider it. This article discusses telecommuting's potential impact on contact with users, length of employment, job descriptions, budgets, management style, communication, and workflow. This option may help libraries retain older…

  3. State Virtual Libraries

    ERIC Educational Resources Information Center

    Pappas, Marjorie L.

    2003-01-01

    Virtual library? Electronic library? Digital library? Online information network? These all apply to the growing number of Web-based resource collections managed by consortiums of state library entities. Some, like "INFOhio" and "KYVL" ("Kentucky Virtual Library"), have been available for a few years, but others are just starting. Searching for…

  4. State Virtual Libraries

    ERIC Educational Resources Information Center

    Pappas, Marjorie L.

    2003-01-01

    Virtual library? Electronic library? Digital library? Online information network? These all apply to the growing number of Web-based resource collections managed by consortiums of state library entities. Some, like "INFOhio" and "KYVL" ("Kentucky Virtual Library"), have been available for a few years, but others are just starting. Searching for…

  5. Personal Virtual Libraries

    ERIC Educational Resources Information Center

    Pappas, Marjorie L.

    2004-01-01

    Virtual libraries are becoming more and more common. Most states have a virtual library. A growing number of public libraries have a virtual presence on the Web. Virtual libraries are a growing addition to school library media collections. The next logical step would be personal virtual libraries. A personal virtual library (PVL) is a collection…

  6. Personal Virtual Libraries

    ERIC Educational Resources Information Center

    Pappas, Marjorie L.

    2004-01-01

    Virtual libraries are becoming more and more common. Most states have a virtual library. A growing number of public libraries have a virtual presence on the Web. Virtual libraries are a growing addition to school library media collections. The next logical step would be personal virtual libraries. A personal virtual library (PVL) is a collection…

  7. Electronic Library: A TERI Experiment.

    ERIC Educational Resources Information Center

    Kar, Debal C.; Deb, Subrata; Kumar, Satish

    2003-01-01

    Discusses the development of Electronic Library at TERI (The Energy and Resources Institute, New Delhi). Highlights include: hardware and software used; the digital library/Virtual Electronic Library; directory of Internet journals; virtual reference resources; electronic collection/Physical Electronic Library; downloaded online full-length…

  8. Electronic Library: A TERI Experiment.

    ERIC Educational Resources Information Center

    Kar, Debal C.; Deb, Subrata; Kumar, Satish

    2003-01-01

    Discusses the development of Electronic Library at TERI (The Energy and Resources Institute, New Delhi). Highlights include: hardware and software used; the digital library/Virtual Electronic Library; directory of Internet journals; virtual reference resources; electronic collection/Physical Electronic Library; downloaded online full-length…

  9. Virtual Libraries: Service Realities.

    ERIC Educational Resources Information Center

    Novak, Jan

    2002-01-01

    Discussion of changes in society that have resulted from information and communication technologies focuses on changes in libraries and a new market for library services with new styles of clients. Highlights client service issues to be considered when transitioning to a virtual library situation. (Author/LRW)

  10. Virtual Libraries: Service Realities.

    ERIC Educational Resources Information Center

    Novak, Jan

    2002-01-01

    Discussion of changes in society that have resulted from information and communication technologies focuses on changes in libraries and a new market for library services with new styles of clients. Highlights client service issues to be considered when transitioning to a virtual library situation. (Author/LRW)

  11. The use of quality benchmarking in assessing web resources for the dermatology virtual branch library of the National electronic Library for Health (NeLH).

    PubMed

    Kamel Boulos, M N; Roudsari, A V; Gordon, C; Muir Gray, J A

    2001-01-01

    In 1998, the U.K. National Health Service Information for Health Strategy proposed the implementation of a National electronic Library for Health to provide clinicians, healthcare managers and planners, patients and the public with easy, round the clock access to high quality, up-to-date electronic information on health and healthcare. The Virtual Branch Libraries are among the most important components of the National electronic Library for Health. They aim at creating online knowledge based communities, each concerned with some specific clinical and other health-related topics. This study is about the envisaged Dermatology Virtual Branch Libraries of the National electronic Library for Health. It aims at selecting suitable dermatology Web resources for inclusion in the forthcoming Virtual Branch Libraries after establishing preliminary quality benchmarking rules for this task. Psoriasis, being a common dermatological condition, has been chosen as a starting point. Because quality is a principal concern of the National electronic Library for Health, the study includes a review of the major quality benchmarking systems available today for assessing health-related Web sites. The methodology of developing a quality benchmarking system has been also reviewed. Aided by metasearch Web tools, candidate resources were hand-selected in light of the reviewed benchmarking systems and specific criteria set by the authors. Over 90 professional and patient-oriented Web resources on psoriasis and dermatology in general are suggested for inclusion in the forthcoming Dermatology Virtual Branch Libraries. The idea of an all-in knowledge-hallmarking instrument for the National electronic Library for Health is also proposed based on the reviewed quality benchmarking systems. Skilled, methodical, organized human reviewing, selection and filtering based on well-defined quality appraisal criteria seems likely to be the key ingredient in the envisaged National electronic Library for

  12. The Use of Quality Benchmarking in Assessing Web Resources for the Dermatology Virtual Branch Library of the National electronic Library for Health (NeLH)

    PubMed Central

    Roudsari, AV; Gordon, C; Gray, JA Muir

    2001-01-01

    Background In 1998, the U.K. National Health Service Information for Health Strategy proposed the implementation of a National electronic Library for Health to provide clinicians, healthcare managers and planners, patients and the public with easy, round the clock access to high quality, up-to-date electronic information on health and healthcare. The Virtual Branch Libraries are among the most important components of the National electronic Library for Health . They aim at creating online knowledge based communities, each concerned with some specific clinical and other health-related topics. Objectives This study is about the envisaged Dermatology Virtual Branch Libraries of the National electronic Library for Health . It aims at selecting suitable dermatology Web resources for inclusion in the forthcoming Virtual Branch Libraries after establishing preliminary quality benchmarking rules for this task. Psoriasis, being a common dermatological condition, has been chosen as a starting point. Methods Because quality is a principal concern of the National electronic Library for Health, the study includes a review of the major quality benchmarking systems available today for assessing health-related Web sites. The methodology of developing a quality benchmarking system has been also reviewed. Aided by metasearch Web tools, candidate resources were hand-selected in light of the reviewed benchmarking systems and specific criteria set by the authors. Results Over 90 professional and patient-oriented Web resources on psoriasis and dermatology in general are suggested for inclusion in the forthcoming Dermatology Virtual Branch Libraries. The idea of an all-in knowledge-hallmarking instrument for the National electronic Library for Health is also proposed based on the reviewed quality benchmarking systems. Conclusions Skilled, methodical, organized human reviewing, selection and filtering based on well-defined quality appraisal criteria seems likely to be the key ingredient

  13. The Virtual Library

    ERIC Educational Resources Information Center

    Valenza, Joyce Kasman

    2006-01-01

    Today's school libraries must meet student needs as both a physical and virtual space. Existing both offline and online, they must offer around-the-clock access as well as instruction and guidance that support the face-to-face interactions of students with librarians and classroom teachers. Although students are often technologically proficient,…

  14. Virtual Libraries: Service Realities.

    ERIC Educational Resources Information Center

    Novak, Jan

    This paper discusses client service issues to be considered when transitioning to a virtual library situation. Themes related to the transitional nature of society in the knowledge era are presented, including: paradox and a contradictory nature; blurring of boundaries; networks, systems, and holistic thinking; process/not product, becoming/not…

  15. The Virtual Library

    ERIC Educational Resources Information Center

    Valenza, Joyce Kasman

    2006-01-01

    Today's school libraries must meet student needs as both a physical and virtual space. Existing both offline and online, they must offer around-the-clock access as well as instruction and guidance that support the face-to-face interactions of students with librarians and classroom teachers. Although students are often technologically proficient,…

  16. Virtual screening of virtual libraries.

    PubMed

    Green, Darren V S

    2003-01-01

    Virtual screening of virtual libraries (VSVL) is a rapidly changing area of research. Great efforts are being made to produce better algorithms, selection methods and infrastructure. Yet, the number of successful examples in the literature is not impressive, although the quality of work certainly is high. Why is this? One reason is that these methods tend to be applied at the lead generation stage and therefore there is a large lead-time before successful examples appear in the literature. However, any computational chemist would confirm that these methods are successful and there exists a glut of start-up companies specialising in virtual screening. Moreover, the scientific community would not be focussing so much attention on this area if it were not yielding results. Even so, the paucity of literature data is certainly a hindrance to the development of better methods. The VSVL process is unique within the discovery process, in that it is the only method that can screen the > 10(30) genuinely novel molecules out there. Already, some VSVL methods are evaluating 10(13) compounds, a capacity that high throughput screening can only dream of. There is a huge potential advantage for the company that develops efficient and effective methods, for lead generation, lead hopping and optimization of both potency and ADME properties. To do this, it requires more than the software, it requires confidence to exploit the methodology, to commit synthesis on the basis of it, and to build this approach into the medicinal chemistry strategy. It is a fact that these tools remain quite daunting for the majority of scientists working at the bench. The routine use of these methods is not simply a matter of education and training. Integration of these methods into accessible and robust end user software, without dilution of the science, must be a priority. We have reached a coincidence, where several technologies have the required level of maturity predictive computational chemistry

  17. The Physical and the Virtual: The Relationship between Library as Place and Electronic Collections

    ERIC Educational Resources Information Center

    Gerke, Jennifer; Maness, Jack M.

    2010-01-01

    A statistical analysis of responses to a LibQUAL+™ survey at the University of Colorado at Boulder (UCB) was conducted to investigate factors related to patrons' satisfaction with electronic collections. It was found that a respondent's discipline was not related to his or her satisfaction with the Libraries' electronic collection, nor was the…

  18. The Physical and the Virtual: The Relationship between Library as Place and Electronic Collections

    ERIC Educational Resources Information Center

    Gerke, Jennifer; Maness, Jack M.

    2010-01-01

    A statistical analysis of responses to a LibQUAL+™ survey at the University of Colorado at Boulder (UCB) was conducted to investigate factors related to patrons' satisfaction with electronic collections. It was found that a respondent's discipline was not related to his or her satisfaction with the Libraries' electronic collection, nor was the…

  19. Creating an Online Library To Support a Virtual Learning Community.

    ERIC Educational Resources Information Center

    Sandelands, Eric

    1998-01-01

    International Management Centres (IMC), an independent business school, and Anbar Electronic Intelligence (AEI), a database publisher, have created a virtual library for IMC's virtual business school. Topics discussed include action learning; IMC's partnership with AEI; the virtual university model; designing virtual library resources; and…

  20. The Virtual Library: Computers in Libraries Canada.

    ERIC Educational Resources Information Center

    Saunders, Laverna

    1992-01-01

    Reports on a postconference workshop on virtual libraries that was presented at the third annual Computers in Libraries Canada Conference. Highlights include networks; technological change; administrative issues, including organizational structure, staff training, strategic planning, and financial resources; a case study of the University of…

  1. Marketing the Virtual Library

    ERIC Educational Resources Information Center

    Fagan, Jody Condit

    2009-01-01

    Far more people are familiar with their local public or college library facility than their library's website and online resources. In fact, according to a recent survey, 96% of Americans said they had visited a library in person, but less than one-third have visited their online library. Since everyone agrees that online library resources are…

  2. Marketing the Virtual Library

    ERIC Educational Resources Information Center

    Fagan, Jody Condit

    2009-01-01

    Far more people are familiar with their local public or college library facility than their library's website and online resources. In fact, according to a recent survey, 96% of Americans said they had visited a library in person, but less than one-third have visited their online library. Since everyone agrees that online library resources are…

  3. Finding Information on the State Virtual Libraries

    ERIC Educational Resources Information Center

    Pappas, Marjorie L.

    2004-01-01

    The number of state virtual libraries is rapidly expanding. These virtual libraries might include collections of subscription databases; state weblinks and resources; digital collections of primary source documents; and a state union catalog or links to school, public, and academic library catalogs. Most of these virtual libraries include an…

  4. Finding Information on the State Virtual Libraries

    ERIC Educational Resources Information Center

    Pappas, Marjorie L.

    2004-01-01

    The number of state virtual libraries is rapidly expanding. These virtual libraries might include collections of subscription databases; state weblinks and resources; digital collections of primary source documents; and a state union catalog or links to school, public, and academic library catalogs. Most of these virtual libraries include an…

  5. Virtual screening of compound libraries.

    PubMed

    Cerqueira, Nuno M F S A; Sousa, Sérgio F; Fernandes, Pedro A; Ramos, Maria João

    2009-01-01

    During the last decade, Virtual Screening (VS) has definitively established itself as an important part of the drug discovery and development process. VS involves the selection of likely drug candidates from large libraries of chemical structures by using computational methodologies, but the generic definition of VS encompasses many different methodologies. This chapter provides an introduction to the field by reviewing a variety of important aspects, including the different types of virtual screening methods, and the several steps required for a successful virtual screening campaign within a state-of-the-art approach, from target selection to postfilter application. This analysis is further complemented with a small collection important VS success stories.

  6. The virtual library: Coming of age

    NASA Technical Reports Server (NTRS)

    Hunter, Judy F.; Cotter, Gladys A.

    1994-01-01

    With the high speed networking capabilities, multiple media options, and massive amounts of information that exist in electronic format today, the concept of a 'virtual' library or 'library without walls' is becoming viable. In virtual library environment, the information processed goes beyond the traditional definition of documents to include the results of scientific and technical research and development (reports, software, data) recorded in any format or media: electronic, audio, video, or scanned images. Network access to information must include tools to help locate information sources and navigate the networks to connect to the sources, as well as methods to extract the relevant information. Graphical User Interfaces (GUI's) that are intuitive and navigational tools such as Intelligent Gateway Processors (IGP) will provide users with seamless and transparent use of high speed networks to access, organize, and manage information. Traditional libraries will become points of electronic access to information on multiple medias. The emphasis will be towards unique collections of information at each library rather than entire collections at every library. It is no longer a question of whether there is enough information available; it is more a question of how to manage the vast volumes of information. The future equation will involve being able to organize knowledge, manage information, and provide access at the point of origin.

  7. The virtual library: Coming of age

    NASA Technical Reports Server (NTRS)

    Hunter, Judy F.; Cotter, Gladys A.

    1994-01-01

    With the high speed networking capabilities, multiple media options, and massive amounts of information that exist in electronic format today, the concept of a 'virtual' library or 'library without walls' is becoming viable. In virtual library environment, the information processed goes beyond the traditional definition of documents to include the results of scientific and technical research and development (reports, software, data) recorded in any format or media: electronic, audio, video, or scanned images. Network access to information must include tools to help locate information sources and navigate the networks to connect to the sources, as well as methods to extract the relevant information. Graphical User Interfaces (GUI's) that are intuitive and navigational tools such as Intelligent Gateway Processors (IGP) will provide users with seamless and transparent use of high speed networks to access, organize, and manage information. Traditional libraries will become points of electronic access to information on multiple medias. The emphasis will be towards unique collections of information at each library rather than entire collections at every library. It is no longer a question of whether there is enough information available; it is more a question of how to manage the vast volumes of information. The future equation will involve being able to organize knowledge, manage information, and provide access at the point of origin.

  8. The USF Libraries Virtual Library Project: A Blueprint for Development.

    ERIC Educational Resources Information Center

    Metz-Wiseman, Monica; Silver, Susan; Hanson, Ardis; Johnston, Judy; Grohs, Kim; Neville, Tina; Sanchez, Ed; Gray, Carolyn

    This report of the Virtual Library Planning Committee (VLPC) is intending to serve as a blueprint for the University of South Florida (USF) Libraries as it shifts from print to digital formats in its evolution into a "Virtual Library". A comprehensive planning process is essential for the USF Libraries to make optimum use of technology,…

  9. The Michigan Electronic Library.

    ERIC Educational Resources Information Center

    Davidsen, Susanna L.

    1997-01-01

    Describes the Michigan Electronic Library (MEL), the largest evaluated and organized Web-based library of Internet resources, that was designed to provide a library of electronic information resources selected by librarians. MEL's partnership is explained, the collection is described, and future developments are considered. (LRW)

  10. Library Virtual Tours: A Case Study

    ERIC Educational Resources Information Center

    Ashmore, Beth; Grogg, Jill E.

    2004-01-01

    Virtual tours delivered via the Web have become a common tool for both instruction and outreach. This article is a case study of the creation of a virtual tour for a university library and is intended to provide others interested in creating a virtual tour of their library the opportunity to learn from the mistakes and successes of fellow…

  11. Library Virtual Tours: A Case Study

    ERIC Educational Resources Information Center

    Ashmore, Beth; Grogg, Jill E.

    2004-01-01

    Virtual tours delivered via the Web have become a common tool for both instruction and outreach. This article is a case study of the creation of a virtual tour for a university library and is intended to provide others interested in creating a virtual tour of their library the opportunity to learn from the mistakes and successes of fellow…

  12. Virtual Reference Service in Academic Libraries in West Africa

    ERIC Educational Resources Information Center

    Sekyere, Kwabena

    2011-01-01

    As technology continues to advance, libraries in Europe and America continue to improve upon their virtual reference services by employing new Web technologies and applying them to existing services. West African academic libraries have begun providing resources electronically to their users but still typically lag behind in the services they…

  13. Virtual Library: Providing Accessible Online Resources.

    ERIC Educational Resources Information Center

    Kelly, Rob

    2001-01-01

    Describes e-global library, a virtual library based on the Jones International University's library that organizes Internet resources to make them more accessible to students at all skill levels. Highlights include online tutorials; research guides; financial aid and career development information; and possible partnerships with other digital…

  14. The Virtual Library: Pitfalls, Promises, and Potential.

    ERIC Educational Resources Information Center

    Rooks, Dana

    1993-01-01

    Discusses components of the emerging virtual library. Highlights include adopting technology to enhance library services; navigation problems; shared resources and services; costs; implementation challenges, including library instruction programs; control over intellectual content; technical design issues; and a brief overview of current virtual…

  15. Virtual Library: Providing Accessible Online Resources.

    ERIC Educational Resources Information Center

    Kelly, Rob

    2001-01-01

    Describes e-global library, a virtual library based on the Jones International University's library that organizes Internet resources to make them more accessible to students at all skill levels. Highlights include online tutorials; research guides; financial aid and career development information; and possible partnerships with other digital…

  16. The Virtual Library: Pitfalls, Promises, and Potential.

    ERIC Educational Resources Information Center

    Rooks, Dana

    1993-01-01

    Discusses components of the emerging virtual library. Highlights include adopting technology to enhance library services; navigation problems; shared resources and services; costs; implementation challenges, including library instruction programs; control over intellectual content; technical design issues; and a brief overview of current virtual…

  17. Assessing Library Automation and Virtual Library Development in Four Academic Libraries in Oyo, Oyo State, Nigeria

    ERIC Educational Resources Information Center

    Gbadamosi, Belau Olatunde

    2011-01-01

    The paper examines the level of library automation and virtual library development in four academic libraries. A validated questionnaire was used to capture the responses from academic librarians of the libraries under study. The paper discovers that none of the four academic libraries is fully automated. The libraries make use of librarians with…

  18. The road to virtual: the Sauls Memorial Virtual Library journey.

    PubMed

    Waddell, Stacie; Harkness, Amy; Cohen, Mark L

    2014-01-01

    The Sauls Memorial Virtual Library closed its physical space in 2012. This article outlines the reasons for this change and how the library staff and hospital leadership planned and executed the enormous undertaking. Outcomes of the change and lessons learned from the process are discussed.

  19. Measuring Effectiveness in a Virtual Library

    ERIC Educational Resources Information Center

    Finch, Jannette L.

    2010-01-01

    Measuring quality of service in academic libraries traditionally includes quantifiable data such as collection size, staff counts, circulation numbers, reference service statistics, qualitative analyses of customer satisfaction, shelving accuracy, and building comfort. In the libraries of the third millennium, virtual worlds, Web content and…

  20. Helping Students Use Virtual Libraries Effectively.

    ERIC Educational Resources Information Center

    Fitzgerald, Mary Ann; Galloway, Chad

    2001-01-01

    Describes a study in which online behavior of high school and undergraduate students using GALILEO (Georgia Library Learning Online), a virtual library, were observed. Topics include cognitive demands; technology literacy; domain knowledge; search strategies; relevance; evaluation of information; information literacy standards; and suggestions to…

  1. Measuring Effectiveness in a Virtual Library

    ERIC Educational Resources Information Center

    Finch, Jannette L.

    2010-01-01

    Measuring quality of service in academic libraries traditionally includes quantifiable data such as collection size, staff counts, circulation numbers, reference service statistics, qualitative analyses of customer satisfaction, shelving accuracy, and building comfort. In the libraries of the third millennium, virtual worlds, Web content and…

  2. The Human Element in the Virtual Library.

    ERIC Educational Resources Information Center

    Saunders, Laverna M.

    1999-01-01

    Introduces the concept of the virtual library and explores how the increasing reliance on computers and digital information has affected library users and staff. Discusses users' expectations, democratization of access, human issues, organizational change, technostress, ergonomics, assessment, and strategies for success and survival. Contains 35…

  3. Helping Students Use Virtual Libraries Effectively.

    ERIC Educational Resources Information Center

    Fitzgerald, Mary Ann; Galloway, Chad

    2001-01-01

    Describes a study in which online behavior of high school and undergraduate students using GALILEO (Georgia Library Learning Online), a virtual library, were observed. Topics include cognitive demands; technology literacy; domain knowledge; search strategies; relevance; evaluation of information; information literacy standards; and suggestions to…

  4. Libraries' Place in Virtual Social Networks

    ERIC Educational Resources Information Center

    Mathews, Brian S.

    2007-01-01

    Do libraries belong in the virtual world of social networking? With more than 100 million users, this environment is impossible to ignore. A rising philosophy for libraries, particularly in blog-land, involves the concept of being where the users are. Simply using new media to deliver an old message is not progress. Instead, librarians should…

  5. The Human Element in the Virtual Library.

    ERIC Educational Resources Information Center

    Saunders, Laverna M.

    1999-01-01

    Introduces the concept of the virtual library and explores how the increasing reliance on computers and digital information has affected library users and staff. Discusses users' expectations, democratization of access, human issues, organizational change, technostress, ergonomics, assessment, and strategies for success and survival. Contains 35…

  6. Virtual Libraries: Meeting the Corporate Challenge.

    ERIC Educational Resources Information Center

    DiMattia, Susan S.; Blumenstein, Lynn C.

    1999-01-01

    Discusses virtual libraries in corporate settings from the viewpoint of five special librarians. Highlights include competitive advantage, space and related collection issues, the use of technology, corporate culture, information overload, library vulnerability and downsizing, and the importance of service over format. (LRW)

  7. Rhode Island: Multi-library Networks and the Virtual Library.

    ERIC Educational Resources Information Center

    Weaver, Barbara; And Others

    1996-01-01

    Describes the multilibrary network in Rhode Island which provides electronic access to public information. Highlights include the role of the Department of State Library Services; Internet access issues; a network for elementary and secondary schools that provides access to university and public libraries; a higher education library network; a…

  8. Virtual Campuses, Virtual Libraries in SREB States.

    ERIC Educational Resources Information Center

    Southern Regional Education Board, Atlanta, GA.

    This report provides a snapshot of Southern Regional Education Board (SREB) states' electronic initiatives and demonstrates states' commitment to expanding learning opportunities for their residents. The following five common objectives emerging from a review of state activities are listed: (1) to develop the economy and train the work force; (2)…

  9. A rural virtual health sciences library project: research findings with implications for next generation library services.

    PubMed

    Richwine, M P; McGowan, J J

    2001-01-01

    The Shared Hospital Electronic Library of Southern Indiana (SHELSI) research project was designed to determine whether access to a virtual health sciences library and training in its use would support medical decision making in rural southern Indiana and achieve the same level of impact seen by targeted information services provided by health sciences librarians in urban hospitals. Based on the results of a needs assessment, a virtual medical library was created; various levels of training were provided. Virtual library users were asked to complete a Likert-type survey, which included questions on intent of use and impact of use. At the conclusion of the project period, structured interviews were conducted. Impact of the virtual health sciences library showed a strong correlation with the impact of information provided by health sciences librarians. Both interventions resulted in avoidance of adverse health events. Data collected from the structured interviews confirmed the perceived value of the virtual library. While librarians continue to hold a strong position in supporting information access for health care providers, their roles in the information age must begin to move away from providing information toward selecting and organizing knowledge resources and instruction in their use.

  10. A rural virtual health sciences library project: research findings with implications for next generation library services*

    PubMed Central

    Richwine, Margaret (Peggy); McGowan, Julie J.

    2001-01-01

    Purpose: The Shared Hospital Electronic Library of Southern Indiana (SHELSI) research project was designed to determine whether access to a virtual health sciences library and training in its use would support medical decision making in rural southern Indiana and achieve the same level of impact seen by targeted information services provided by health sciences librarians in urban hospitals. Methods: Based on the results of a needs assessment, a virtual medical library was created; various levels of training were provided. Virtual library users were asked to complete a Likert-type survey, which included questions on intent of use and impact of use. At the conclusion of the project period, structured interviews were conducted. Results: Impact of the virtual health sciences library showed a strong correlation with the impact of information provided by health sciences librarians. Both interventions resulted in avoidance of adverse health events. Data collected from the structured interviews confirmed the perceived value of the virtual library. Conclusion: While librarians continue to hold a strong position in supporting information access for health care providers, their roles in the information age must begin to move away from providing information toward selecting and organizing knowledge resources and instruction in their use. PMID:11209799

  11. The Virtual Library in Action

    SciTech Connect

    Addis, Louise

    1999-07-02

    The SLAC Library has for many years provided SPIRES-HEP, a 300,000 record bibliographic database, to the world particle physics community via the Internet as well as through clone sites in Europe and Japan. The 1991 introduction of the e-print archives at LANL coupled with the World-Wide-Web (WWW) from CERN suddenly made it possible to provide easy linkage between bibliographic database records and the actual full-text of papers. The SLAC Library has turned this possibility into reality by converting hundreds of TeX source documents each month into viewable postscript complete with figures. These (now more than 20,000) postscript files are linked to the HEP database, and the full-text is rendered universally visible via WWW. We discuss the project, the collaboration of physicists and librarians, what is easy, what is hard, and our vision for the future.

  12. The Problem Patron and the Academic Library Web Site as Virtual Reference Desk.

    ERIC Educational Resources Information Center

    Taylor, Daniel; Porter, George S.

    2002-01-01

    Considers problem library patrons in a virtual environment based on experiences at California Institute of Technology's Web site and its use for virtual reference. Discusses the virtual reference desk concept; global visibility and access to the World Wide Web; problematic email; and advantages in the electronic environment. (LRW)

  13. Organizational Aspects of the Virtual Library: A Survey of Academic Libraries.

    ERIC Educational Resources Information Center

    Travica, Bob

    1999-01-01

    Reviews the literature on changes in academic library organizations and describes the results of a survey of library directors that investigated concepts of a virtual library, both as digital technology and as a new organizational concept. Discusses models of virtual libraries and library networking, and includes a copy of the questionnaire.…

  14. Reading factor: a bibliometric tool to manage a virtual library.

    PubMed

    Thirion, B; Darmoni, S J; Benichou, J

    2001-01-01

    Among the many bibliometric criteria used to evaluate biomedical journals, the impact factor is the most commonly used. Despite its limitations, it quantifies the influence of a journal on secondary publications. It does not however evaluate the practical usefulness of primary documents. Usefulness is field-related and varies greatly among specialities. We introduce a new bibliographic criterion, the "reading factor", and define it as the ratio between the number of electronic consultations of a particular journal (i.e., number of clicks on a hyper-link) and the mean number of electronic consultations of all the journals studied (itself calculated by dividing the total number of electronic accesses by the number of journals in the database). We describe its observed distribution, relative to that of the impact factor, based on electronic consultation records from our University Hospital medical digital library, where full-text electronic versions of 45 major biomedical journals have been available since December 1997. From this analysis we found no correlation between the 1999 reading factor and the 1998 impact factor of these 45 journals, and we observed a dramatic change in the hierarchy of journals upon using the reading factor as the yardstick rather than the impact factor. Moreover, we describe how using the reading factor has helped in managing the collection of our University Hospital's virtual library. The selection of journals to be discarded from the virtual library for the year 2001 was based on journals' RF values and this process will repeated over the coming years. The reading factor also permits a cost-analysis of a virtual library. The measurement of the reading factor is highly automated, practical and efficient. It appears as a new tool for electronic collection management by librarians, well fitting with economical data.

  15. [The virtual library in equity, health, and human development].

    PubMed

    Valdés, América

    2002-01-01

    This article attempts to describe the rationale that has led to the development of information sources dealing with equity, health, and human development in countries of Latin America and the Caribbean within the context of the Virtual Health Library (Biblioteca Virtual en Salud, BVS). Such information sources include the scientific literature, databases in printed and electronic format, institutional directories and lists of specialists, lists of events and courses, distance education programs, specialty journals and bulletins, as well as other means of disseminating health information. The pages that follow deal with the development of a Virtual Library in Equity, Health, and Human Development, an effort rooted in the conviction that decision-making and policy geared toward achieving greater equity in health must, of necessity, be based on coherent, well-organized, and readily accessible first-rate scientific information. Information is useless unless it is converted into knowledge that benefits society. The Virtual Library in Equity, Health, and Human Development is a coordinated effort to develop a decentralized regional network of scientific information sources, with strict quality control, from which public officials can draw data and practical examples that can help them set health and development policies geared toward achieving greater equity for all.

  16. The Evolving Virtual Library: Visions and Case Studies.

    ERIC Educational Resources Information Center

    Saunders, Laverna M., Ed.

    This book addresses many of the practical issues involved in developing the virtual library. Seven presentations from the Eighth Annual Computers in Libraries Conference are included in this book in augmented form. The papers are supplemented by "The Evolving Virtual Library: An Overview" (Laverna M. Saunders and Maurice Mitchell), a…

  17. Virtual Libraries and Education in Virtual Worlds: Twenty-First Century Library Services

    ERIC Educational Resources Information Center

    Bell, Lori; Lindbloom, Mary-Carol; Peters, Tom; Pope, Kitty

    2008-01-01

    As the use of the Internet and time spent on the Internet by individuals grows, and the use of virtual worlds like Active Worlds and Second Life increases, the library needs to have an interactive place and role in these worlds as well as a bricks and mortar space. This article provides an overview of what some libraries are doing in these worlds,…

  18. Automated recycling of chemistry for virtual screening and library design.

    PubMed

    Vainio, Mikko J; Kogej, Thierry; Raubacher, Florian

    2012-07-23

    An early stage drug discovery project needs to identify a number of chemically diverse and attractive compounds. These hit compounds are typically found through high-throughput screening campaigns. The diversity of the chemical libraries used in screening is therefore important. In this study, we describe a virtual high-throughput screening system called Virtual Library. The system automatically "recycles" validated synthetic protocols and available starting materials to generate a large number of virtual compound libraries, and allows for fast searches in the generated libraries using a 2D fingerprint based screening method. Virtual Library links the returned virtual hit compounds back to experimental protocols to quickly assess the synthetic accessibility of the hits. The system can be used as an idea generator for library design to enrich the screening collection and to explore the structure-activity landscape around a specific active compound.

  19. The Electronic Library Program: Developing Networked Electronic Library Collections.

    ERIC Educational Resources Information Center

    Butler, Brett

    1991-01-01

    The Memex Research Institute (MRI), an independent nonprofit research and development organization, has created an electronic library program of shared research and development to make the collective vision of Vannevar Bush's "memex" more concrete. Program is working toward the creation of large, publicly available indexed electronic image…

  20. Surfing for Knowledge: Virtual Libraries and Books on the Web

    ERIC Educational Resources Information Center

    Wicks, Pamela

    2011-01-01

    Virtual environments such as Second Life (SL) may provide a way to connect with today's digital native and increase the readership of the community college student, both in virtual and real world libraries. Many colleges and universities already have a presence in SL. Books and services typically found in a "brick and mortar" library can…

  1. Surfing for Knowledge: Virtual Libraries and Books on the Web

    ERIC Educational Resources Information Center

    Wicks, Pamela

    2011-01-01

    Virtual environments such as Second Life (SL) may provide a way to connect with today's digital native and increase the readership of the community college student, both in virtual and real world libraries. Many colleges and universities already have a presence in SL. Books and services typically found in a "brick and mortar" library can…

  2. Library Networks and Electronic Publishing.

    ERIC Educational Resources Information Center

    Olvey, Lee D.

    1995-01-01

    Provides a description of present and proposed plans and strategies of OCLC (Online Computer Library Center) and their relationship to electronic publishing. FirstSearch (end-user access to secondary information), GUIDON (electronic journals online) and FastDoc (document delivery) are emphasized. (JKP)

  3. Electronic Blending in Virtual Microscopy

    ERIC Educational Resources Information Center

    Maybury, Terrence S.; Farah, Camile S.

    2010-01-01

    Virtual microscopy (VM) is a relatively new technology that transforms the computer into a microscope. In essence, VM allows for the scanning and transfer of glass slides from light microscopy technology to the digital environment of the computer. This transition is also a function of the change from print knowledge to electronic knowledge, or as…

  4. An Electronic Bulletin Board: LIBRARY.

    ERIC Educational Resources Information Center

    Tinsley, G. Lynn

    1989-01-01

    Describes an electronic bulletin board called LIBRARY that was developed at Carnegie Mellon University to display the tables of contents of scholarly journals and timely postings of new monographs in the fields of computer science and robotics. Areas discussed include preparation involved in beginning the service, management and upkeep, feedback…

  5. [Reproductive health: a contribution to the evaluation of a virtual library].

    PubMed

    Alvarez, Maria do Carmo Avamilano; Cuenca, Angela Maria Belloni; Noronha, Daisy Pires; Schor, Néia

    2007-10-01

    Virtual libraries have been implemented in an attempt to organize scientific information found in the Internet, including the Biblioteca Virtual de Saúde Reprodutiva (BVSR), or Virtual Library on Reproductive Health. The aim is to provide quality information to researchers in the reproductive health field. The current study evaluates the use of the BVSR, emphasizing the users' expectations, difficulties, and suggestions. The study adopted a qualitative methodology. The focus group technique was applied to Internet chat groups through which reproductive health researchers communicated. Users expressed their expectations regarding information, highlighting the lack of time and the need to quickly obtain precise data. Use of virtual libraries for research increases where there is more trust in the institutions responsible for maintaining them. Researchers suggested the following: greater dissemination of the BVSR, publication of an electronic newsletter, and creation of a communications channel between the BVSR and users in order to foster intelligent collective communication.

  6. Leading Libraries: Virtual Reference in Libraries: Remote Patrons Heading Your Way?

    ERIC Educational Resources Information Center

    Helfer, Doris Small

    2001-01-01

    Discusses the decline in reference statistics in academic libraries and considers the role of access to information via the Internet. Highlights include patron expectations and demands; commercial Web reference services; and virtual reference desk software so libraries can offer 24 hour service, including public libraries. (LRW)

  7. Leading Libraries: Virtual Reference in Libraries: Remote Patrons Heading Your Way?

    ERIC Educational Resources Information Center

    Helfer, Doris Small

    2001-01-01

    Discusses the decline in reference statistics in academic libraries and considers the role of access to information via the Internet. Highlights include patron expectations and demands; commercial Web reference services; and virtual reference desk software so libraries can offer 24 hour service, including public libraries. (LRW)

  8. User Preferences in Reference Services: Virtual Reference and Academic Libraries

    ERIC Educational Resources Information Center

    Cummings, Joel; Cummings, Lara; Frederiksen, Linda

    2007-01-01

    This study examines the use of chat in an academic library's user population and where virtual reference services might fit within the spectrum of public services offered by academic libraries. Using questionnaires, this research demonstrates that many within the academic community are open to the idea of chat-based reference or using chat for…

  9. User Preferences in Reference Services: Virtual Reference and Academic Libraries

    ERIC Educational Resources Information Center

    Cummings, Joel; Cummings, Lara; Frederiksen, Linda

    2007-01-01

    This study examines the use of chat in an academic library's user population and where virtual reference services might fit within the spectrum of public services offered by academic libraries. Using questionnaires, this research demonstrates that many within the academic community are open to the idea of chat-based reference or using chat for…

  10. Lotus Notes Databases: The Foundation of a Virtual Library.

    ERIC Educational Resources Information Center

    Liberman, Kristen; Rich, Jane L.

    1993-01-01

    Describes the transformation of the Lotus Development Corporation's corporate library from a paper-based information service to a virtual library using Lotus Notes as the underlying development platform. Lotus Notes' tracking, broadcast, reference, and discussion applications are presented; and applications being developed by other corporations…

  11. The Influence of the Electronic Library on Library Management: A Technological University Library Experience.

    ERIC Educational Resources Information Center

    Roitbert, Nurit

    This paper discusses the reorganization of libraries in order to adopt new techniques and to incorporate the electronic library, focusing on the Technion-Israel Institute of Technology. The first section addresses manpower and the electronic library, including processing electronic journals, justification for the traditional library organization…

  12. The Role of a Virtual Library in the Coming Decades

    NASA Astrophysics Data System (ADS)

    Narlikar, J. V.

    2010-10-01

    This paper consists of the keynote address presented by Dr. Narlikar, distinguished and renowned scholar and founder-director of the Inter-University Centre for Astronomy and Astrophysics. Dr. Narlikar critically examines the nature of library and information centers of the past and future through anecdote, example, and philosophical examination. He discusses the synergies between astronomical research and library science, speculates on the future of authenticity in a web-based environment and describes the futuristic "virtual library."

  13. Content Analysis of Virtual Reference Data: Reshaping Library Website Design.

    PubMed

    Fan, Suhua Caroline; Welch, Jennifer M

    2016-01-01

    An academic health sciences library wanted to redesign its website to provide better access to health information in the community. Virtual reference data were used to provide information about user searching behavior. This study analyzed three years (2012-2014) of virtual reference data, including e-mail questions, text messaging, and live chat transcripts, to evaluate the library website for redesigning, especially in areas such as the home page, patrons' terminology, and issues prompting patrons to ask for help. A coding system based on information links in the current library website was created to analyze the data.

  14. Library Instruction in the Electronic Library: The University of Arizona's Electronic Library Education Centers.

    ERIC Educational Resources Information Center

    Glogoff, Stuart

    1995-01-01

    Discusses two Electronic Library Education Centers (ELECs) created at the University of Arizona to improve library instruction in the use of online resources. Examines costs of developing ELECs; technical changes experienced; and benefits to users and librarians. A sidebar by Abbie J. Basile identifies Internet resources for planning and/or…

  15. Electronic Publishing and Library Technical Services.

    ERIC Educational Resources Information Center

    Aveney, Brian

    1984-01-01

    Trends in electronic editions, on-demand publishing, and online publishing are reviewed and their potential effects on library services and organization are discussed, including library material selection, acquisitions, cataloging, serials, circulation, and home printers. Thirteen references are provided. (EJS)

  16. Virtual Library on Genetics from Oak Ridge National Laboratory

    DOE Data Explorer

    The World Wide Web (WWW) Virtual Library is a collaborative effort to provide topic indices that break down into many subtopics guiding users to vast resources of information around the world. ORNL hosts the Virtual Library on Genetics as part of the WWWVL's Biosciences topic area. The VL on Genetics is also a collection of links to information resources that supported the DOE Human Genome Project. That project has now evolved into Genomics: GTL. GTL is DOE's next step in genomics--builds on data and resources from the Human Genome Project, the Microbial Genome Program, and systems biology. GTL will accelerate understanding of dynamic living systems for solutions to DOE mission challenges in energy and the environment. The section of the Virtual Library on Genetics that is titled Organisms guides users to genetic information resources and gene sequences for animals, insects, microbes, and plant life.

  17. Production of the next-generation library virtual tour.

    PubMed

    Duncan, J M; Roth, L K

    2001-10-01

    While many libraries offer overviews of their services through their Websites, only a small number of health sciences libraries provide Web-based virtual tours. These tours typically feature photographs of major service areas along with textual descriptions. This article describes the process for planning, producing, and implementing a next-generation virtual tour in which a variety of media elements are integrated: photographic images, 360-degree "virtual reality" views, textual descriptions, and contextual floor plans. Hardware and software tools used in the project are detailed, along with a production timeline and budget, tips for streamlining the process, and techniques for improving production. This paper is intended as a starting guide for other libraries considering an investment in such a project.

  18. Improving Usage Statistics Processing for a Library Consortium: The Virtual Library of Virginia's Experience

    ERIC Educational Resources Information Center

    Matthews, Tansy E.

    2009-01-01

    This article describes the development of the Virtual Library of Virginia (VIVA). The VIVA statistics-processing system remains a work in progress. Member libraries will benefit from the ability to obtain the actual data from the VIVA site, rather than just the summaries, so a project to make these data available is currently being planned. The…

  19. Improving Usage Statistics Processing for a Library Consortium: The Virtual Library of Virginia's Experience

    ERIC Educational Resources Information Center

    Matthews, Tansy E.

    2009-01-01

    This article describes the development of the Virtual Library of Virginia (VIVA). The VIVA statistics-processing system remains a work in progress. Member libraries will benefit from the ability to obtain the actual data from the VIVA site, rather than just the summaries, so a project to make these data available is currently being planned. The…

  20. Library Use of Electronic Bulletin Board Systems.

    ERIC Educational Resources Information Center

    Dewey, Patrick R.; And Others

    1985-01-01

    Four articles outline problems, programing, case studies, and hardware/software selection in library use of microcomputer-based electronic bulletin board systems (BBS). Highlights include the North-Pulaski (Chicago, Illinois) BBS, features of Liverpool Public Library (New York) system, and misuse of a library BBS (obscenity, bulletin board…

  1. Financing the Electronic Library: Models and Options.

    ERIC Educational Resources Information Center

    Waters, Richard L.; Kralisz, Victor Frank

    1981-01-01

    Places the cost considerations associated with public library automation in a framework of public finance comfortable to most administrators, discusses the importance of experience with use patterns in the electronic library in opening up new and innovative financing methods, and stresses the role of the library in the information industry. (JL)

  2. Virtually Embedded: Library Instruction within Second Life

    ERIC Educational Resources Information Center

    Davis, Marian G.; Smith, Carol E.

    2009-01-01

    Embedded librarianship in distance learning courses taught within virtual environments such as Second Life is an emerging, leading-edge practice. This paper describes the experiences of librarians embedded in undergraduate English composition courses taught entirely in Second Life and presents the results of an empirical research study to assess…

  3. The Future Role of Librarians in the Virtual Library Environment.

    ERIC Educational Resources Information Center

    Burke, Liz

    2002-01-01

    Considers the role of librarians in a virtual library environment. Highlights include providing intellectual access to information in any format; evaluating available sources of information; organizing information; ensuring the preservation of information; providing specialized staff to help meet information needs; and the economic impact of…

  4. DELIVERing Library Resources to the Virtual Learning Environment

    ERIC Educational Resources Information Center

    Secker, Jane

    2005-01-01

    Purpose: Examines a project to integrate digital libraries and virtual learning environments (VLE) focusing on requirements for online reading list systems. Design/methodology/approach: Conducted a user needs analysis using interviews and focus groups and evaluated three reading or resource list management systems. Findings: Provides a technical…

  5. University Library Virtual Reference Services: Best Practices and Continuous Improvement

    ERIC Educational Resources Information Center

    Shaw, Kate; Spink, Amanda

    2009-01-01

    The inclusion or not of chat services within Virtual Reference (VR) is an important topic for university libraries. Increasingly, email supported by a Frequently Asked Questions (FAQ) database is suggested in the scholarly literature as the preferred, cost-effective means for providing university VR services. This paper examines these issues and…

  6. The Virtual School Library: Gateway to the Information Superhighway.

    ERIC Educational Resources Information Center

    Kuhlthau, Carol Collier, Ed.; And Others

    This book is a compilation of 14 articles that present a wide range of perspectives on providing access to vast networks of information resources and enabling students to learn in an information-rich environment. The articles, arranged in four parts--overview of important technologies comprising the virtual library, learning in the electronic…

  7. University Library Virtual Reference Services: Best Practices and Continuous Improvement

    ERIC Educational Resources Information Center

    Shaw, Kate; Spink, Amanda

    2009-01-01

    The inclusion or not of chat services within Virtual Reference (VR) is an important topic for university libraries. Increasingly, email supported by a Frequently Asked Questions (FAQ) database is suggested in the scholarly literature as the preferred, cost-effective means for providing university VR services. This paper examines these issues and…

  8. The Future Role of Librarians in the Virtual Library Environment.

    ERIC Educational Resources Information Center

    Burke, Liz

    2002-01-01

    Considers the role of librarians in a virtual library environment. Highlights include providing intellectual access to information in any format; evaluating available sources of information; organizing information; ensuring the preservation of information; providing specialized staff to help meet information needs; and the economic impact of…

  9. CINDI: A Virtual Library Indexing and Discovery System.

    ERIC Educational Resources Information Center

    Desai, Bipin C.; Shinghal, Raijan; Shayan, Nader R.; Zhou, Youquan

    1999-01-01

    Describes a system called CINDI (Concordia INdexing and DIscovery System) for cataloging and searching documents in a distributed virtual library. The document author registers metadata in the form of a semantic header that contains information on syntactic and semantic content, and an expert system fills the semantic header according to accepted…

  10. Virtual Teaching: Library Instruction via the Web.

    ERIC Educational Resources Information Center

    Germain, Carol Anne; Bobish, Gregory

    2002-01-01

    Outlines strategies academic librarians can incorporate to develop effective Web-based tools for library instruction. Topics include Web page design; content; technical and copyright issues; usability and evaluation; site maintenance; Web coding tools; and examples from the University at Albany and the Texas Information Literacy Tutorial (TILT) at…

  11. Information Technology and Libraries: A Virtual Convergence.

    ERIC Educational Resources Information Center

    Young, Arthur P.

    1994-01-01

    It is argued that, with the emergence of new technologies, the traditional missions and "domains" of academic libraries and campus computing services need to be adjusted to support collaboration. Specific collaborative projects linked to strategic plans are recommended over forced mergers or overly ambitious multigoal projects. (MSE)

  12. Library fingerprints: a novel approach to the screening of virtual libraries.

    PubMed

    Klon, Anthony E; Diller, David J

    2007-01-01

    We propose a novel method to prioritize libraries for combinatorial synthesis and high-throughput screening that assesses the viability of a particular library on the basis of the aggregate physical-chemical properties of the compounds using a naïve Bayesian classifier. This approach prioritizes collections of related compounds according to the aggregate values of their physical-chemical parameters in contrast to single-compound screening. The method is also shown to be useful in screening existing noncombinatorial libraries when the compounds in these libraries have been previously clustered according to their molecular graphs. We show that the method used here is comparable or superior to the single-compound virtual screening of combinatorial libraries and noncombinatorial libraries and is superior to the pairwise Tanimoto similarity searching of a collection of combinatorial libraries.

  13. Search Middleware and the Simple Digital Library Interoperability Protocol [and] Meeting the Challenge of Film Research In the Electronic Age [and] Collection-based Persistent Digital Archives-Part 1 [and] The Virtual Union Catalog: A Comparative Study.

    ERIC Educational Resources Information Center

    Paepcke, Andreas; Brandriff, Robert; Janee, Greg; Larson, Ray; Ludaescher, Bertram; Melnik, Sergey; Raghavan, Sriram; [and] Owen, Catherine; Pearson, Tony; Arnold, Stephen; [and] Moore, Reagan; Baru, Chaitan; Rajasekar, Arcot; Ludaescher, Bertram; Marciano, Richard; Wan, Michael; Schroeder, Wayne; Gupta, Amarnath; [and] Coyle, Karen

    2000-01-01

    Includes four articles that discuss: (1) search middleware, or software packages that allow access to information sources for digital libraries; (2) film archives and building online collections of data for use in film research and teaching; (3) digital archives; and (4) a virtual union catalog for the University of California. (LRW)

  14. Living Books and Dynamic Electronic Libraries.

    ERIC Educational Resources Information Center

    Barker, Philip

    1996-01-01

    Discusses changes that have taken place within library systems as a consequence of the emergence of new computer-based technologies. Highlights include using electronic documents; electronic libraries; digital projects; educational applications; and a case study of OASIS (Open Access Student Information Service), a document handling system in the…

  15. Electronic Information Services, Louisiana State University Libraries.

    ERIC Educational Resources Information Center

    Bolner, Smittie; And Others

    Reports prepared by the Louisiana State University (LSU) Libraries Task Force on Electronic Services examine the present level of automated services at the LSU libraries and make recommendations for both long- and short-term plans to handle information in electronic format. The reports, each of which is followed by a list of recommendations, focus…

  16. Navy Distributed Virtual Library Requirements Analysis.

    DTIC Science & Technology

    1995-12-01

    ELECTRONIC JOURNALS AND REFERENCE TOOLS IN ENGINEERING Here are electronic journals and reference tools chosen by the Kresge Engineeri ng Librarians. The...control theory, evolu- tionary programming, fractals, genetic algorithms, information systems, neural networks, nonlinear dynamics, and parallel

  17. Reviewing the Electronic Resources & Libraries Conference

    ERIC Educational Resources Information Center

    Tijerina, Bonnie

    2008-01-01

    The third Electronic Resources & Libraries (ER&L) conference gathered at Georgia Institute of Technology's Global Learning and Conference Center in Atlanta, Georgia, March 18-21, 2008. Over 360 attendees, from six countries and from 80% of the United States, represented their libraries and organizations resulting in a diverse and…

  18. Reviewing the Electronic Resources & Libraries Conference

    ERIC Educational Resources Information Center

    Tijerina, Bonnie

    2008-01-01

    The third Electronic Resources & Libraries (ER&L) conference gathered at Georgia Institute of Technology's Global Learning and Conference Center in Atlanta, Georgia, March 18-21, 2008. Over 360 attendees, from six countries and from 80% of the United States, represented their libraries and organizations resulting in a diverse and…

  19. Remote Electronic Delivery of Information Through Libraries.

    ERIC Educational Resources Information Center

    Sweeney, Richard T.

    1981-01-01

    Considers the impact of Remote Electronic Access and Delivery of Information (READI) upon library services, discusses the uses of online public access information systems in a library setting, describes videotex systems currently in use, and outlines possibilities for the creation of local databases, automatic borrowing of books, and other…

  20. Louisiana State University Libraries' Electronic Imaging Laboratory.

    ERIC Educational Resources Information Center

    Phillips, Faye; Condrey, Richard

    1994-01-01

    Describes Louisiana State University Libraries' Electronic Imaging Laboratory for preservation. The project uses digital imaging technology to reformat rare book materials for access. This technology can exist with traditional conservation procedures. (JLB)

  1. Structure-Based Virtual Screening of Commercially Available Compound Libraries.

    PubMed

    Kireev, Dmitri

    2016-01-01

    Virtual screening (VS) is an efficient hit-finding tool. Its distinctive strength is that it allows one to screen compound libraries that are not available in the lab. Moreover, structure-based (SB) VS also enables an understanding of how the hit compounds bind the protein target, thus laying ground work for the rational hit-to-lead progression. SBVS requires a very limited experimental effort and is particularly well suited for academic labs and small biotech companies that, unlike pharmaceutical companies, do not have physical access to quality small-molecule libraries. Here, we describe SBVS of commercial compound libraries for Mer kinase inhibitors. The screening protocol relies on the docking algorithm Glide complemented by a post-docking filter based on structural protein-ligand interaction fingerprints (SPLIF).

  2. Academic Library Services in Virtual Worlds: An Examination of the Potential for Library Services in Immersive Environments

    ERIC Educational Resources Information Center

    Ryan, Jenna; Porter, Marjorie; Miller, Rebecca

    2010-01-01

    Current literature on libraries is abundant with articles about the uses and the potential of new interactive communication technology, including Web 2.0 tools. Recently, the advent and use of virtual worlds have received top billing in these works. Many library institutions are exploring these virtual environments; this exploration and the…

  3. Academic Library Services in Virtual Worlds: An Examination of the Potential for Library Services in Immersive Environments

    ERIC Educational Resources Information Center

    Ryan, Jenna; Porter, Marjorie; Miller, Rebecca

    2010-01-01

    Current literature on libraries is abundant with articles about the uses and the potential of new interactive communication technology, including Web 2.0 tools. Recently, the advent and use of virtual worlds have received top billing in these works. Many library institutions are exploring these virtual environments; this exploration and the…

  4. The Information Needs of Virtual Users: A Study of Second Life Libraries

    ERIC Educational Resources Information Center

    Chow, Anthony S.; Baity, C. Chase; Zamarripa, Marilyn; Chappell, Pam; Rachlin, David; Vinson, Curtis

    2012-01-01

    As virtual worlds continue to proliferate globally, libraries are faced with the question of whether to provide information services to virtual patrons. This study, utilizing a mixed-method approach of interviews, focus groups, and surveys, represents one of the largest studies of virtual libraries attempted to date. Taking a holistic perspective,…

  5. The Information Needs of Virtual Users: A Study of Second Life Libraries

    ERIC Educational Resources Information Center

    Chow, Anthony S.; Baity, C. Chase; Zamarripa, Marilyn; Chappell, Pam; Rachlin, David; Vinson, Curtis

    2012-01-01

    As virtual worlds continue to proliferate globally, libraries are faced with the question of whether to provide information services to virtual patrons. This study, utilizing a mixed-method approach of interviews, focus groups, and surveys, represents one of the largest studies of virtual libraries attempted to date. Taking a holistic perspective,…

  6. Electronic Reference Works and Library Budgeting Dilemma

    ERIC Educational Resources Information Center

    Lawal, Ibironke O.

    2007-01-01

    The number of electronic resources has climbed up steadily in recent times. Some of these e-resources are reference sources, mostly in Science, Technology and Medicine (STM), which publishers convert to electronic for obvious reasons. The library budgets for materials usually have two main lines, budget for one time purchase (monographs) and…

  7. Electronic Books: Challenges for Academic Libraries.

    ERIC Educational Resources Information Center

    Lonsdale, Ray; Armstrong, Chris

    2001-01-01

    Addresses issues that are central to the acceptance and integration of electronic scholarly monographs and textbooks into the academic library, based on research in the United Kingdom. Findings suggest a slow acceptance of nearly all digital textual resources other than journals as well as low use of electronic information resources in general.…

  8. Humanists, Libraries, Electronic Publishing, and the Future.

    ERIC Educational Resources Information Center

    Sweetland, James H.

    1992-01-01

    Discusses the impact of computerization on humanists and libraries. Highlights include a lack of relevant databases; a reliance on original text; vocabulary and language issues; lack of time pressure; research style; attitudes of humanists toward technology; trends in electronic publishing; hypertext; collection development; electronic mail;…

  9. Electronic Reference Works and Library Budgeting Dilemma

    ERIC Educational Resources Information Center

    Lawal, Ibironke O.

    2007-01-01

    The number of electronic resources has climbed up steadily in recent times. Some of these e-resources are reference sources, mostly in Science, Technology and Medicine (STM), which publishers convert to electronic for obvious reasons. The library budgets for materials usually have two main lines, budget for one time purchase (monographs) and…

  10. Electronic Mail in the Library: A Perspective.

    ERIC Educational Resources Information Center

    Whitaker, Becki

    1989-01-01

    Provides an overview of electronic mail in libraries. Topics discussed include general business applications; interlibrary loan; acquisition and claims systems; document delivery; complete text journal databases; reference requests and answers; obstacles to electronic mail usage; telecommunications; cost factors; and the impact of voice mail and…

  11. Virtual screening methods as tools for drug lead discovery from large chemical libraries.

    PubMed

    Ma, X H; Zhu, F; Liu, X; Shi, Z; Zhang, J X; Yang, S Y; Wei, Y Q; Chen, Y Z

    2012-01-01

    Virtual screening methods have been developed and explored as useful tools for searching drug lead compounds from chemical libraries, including large libraries that have become publically available. In this review, we discussed the new developments in exploring virtual screening methods for enhanced performance in searching large chemical libraries, their applications in screening libraries of ~ 1 million or more compounds in the last five years, the difficulties in their applications, and the strategies for further improving these methods.

  12. Electronic Journal Delivery in Academic Libraries

    ERIC Educational Resources Information Center

    Crothers, Stephen; Prabhu, Margaret; Sullivan, Shirley

    2007-01-01

    The authors recount experiences of the variety of problems and issues involved in providing access to electronic journals in a large academic library. The paper excludes concerns emanating from decisions to subscribe to aggregations such as those produced by vendors like EBSCO, but concentrates on scholarly journals ordered individually, or as…

  13. Electronic Reference Library: Silverplatter's Database Networking Solution.

    ERIC Educational Resources Information Center

    Millea, Megan

    Silverplatter's Electronic Reference Library (ERL) provides wide area network access to its databases using TCP/IP communications and client-server architecture. ERL has two main components: The ERL clients (retrieval interface) and the ERL server (search engines). ERL clients provide patrons with seamless access to multiple databases on multiple…

  14. Western Michigan University Libraries' "Electronic Journal Finder"

    ERIC Educational Resources Information Center

    Gedeon, Randle; Boston, George

    2005-01-01

    This article describes the development of the "Electronic Journal Finder," a TDNet installation for the University Libraries of Western Michigan University. Topics covered include: rationale for subscription project timeline, content, product customization, set-up, maintenance issues, reporting functions, directing URL links, searching…

  15. Electronic Journal Delivery in Academic Libraries

    ERIC Educational Resources Information Center

    Crothers, Stephen; Prabhu, Margaret; Sullivan, Shirley

    2007-01-01

    The authors recount experiences of the variety of problems and issues involved in providing access to electronic journals in a large academic library. The paper excludes concerns emanating from decisions to subscribe to aggregations such as those produced by vendors like EBSCO, but concentrates on scholarly journals ordered individually, or as…

  16. Western Michigan University Libraries' "Electronic Journal Finder"

    ERIC Educational Resources Information Center

    Gedeon, Randle; Boston, George

    2005-01-01

    This article describes the development of the "Electronic Journal Finder," a TDNet installation for the University Libraries of Western Michigan University. Topics covered include: rationale for subscription project timeline, content, product customization, set-up, maintenance issues, reporting functions, directing URL links, searching…

  17. Electronic Document Delivery: New Options for Libraries.

    ERIC Educational Resources Information Center

    Leach, Ronald G.; Tribble, Judith E.

    1993-01-01

    Examines commercial electronic document delivery services that are available to academic libraries. Highlights include collection development issues; criteria for selection and evaluation; remote access systems, including CARL UnCover 2, Faxon Finder and Faxon Xpress, ContentsFirst and ArticleFirst, and CitaDel; and on-site access systems,…

  18. Archiving and Preservation in Electronic Libraries

    DTIC Science & Technology

    2003-04-01

    that is those libraries that are moving toward provision of materials in electronic form, have been swept up in this attitude as well. But, electronic...for consistency within the presentation and are not indicative of general consensus within the community. Born digital - materials that are created...preservation Digitalpreservation - keeping the bits and bytes safe and unaltered for a long period of time Digitization - converting materials in non

  19. Factors Influencing Virtual Patron Satisfaction with Online Library Resources and Services

    ERIC Educational Resources Information Center

    Tyler, Katherine; Hastings, Nancy B.

    2011-01-01

    College students are accessing virtual libraries whether they are on campus or learning from a distance. Academic institutions serving virtual patrons must remain focused on meeting the needs of those library users by continually examining their preferences, their searching behavior, and the information they seek. The purpose of this research was…

  20. Factors Influencing Virtual Patron Satisfaction with Online Library Resources and Services

    ERIC Educational Resources Information Center

    Tyler, Katherine Mary

    2010-01-01

    College students are accessing virtual libraries whether they are on campus or learning from a distance. Academic institutions serving virtual patrons must remain focused on meeting the needs of those library users by continually examining their preferences, their searching behavior, and the information they seek. The purpose of this research was…

  1. Portal to the World: AIHEC Virtual Library Opens Doors for Native Research

    ERIC Educational Resources Information Center

    Kirby, Jane

    2004-01-01

    The Internet keeps growing at lightning speed. Now, "tribal college" students have a tool to assist them in locating accurate information quickly: the American Indian Higher Education Consortium (AIHEC) Virtual Library. The AIHEC Virtual Library provides a focused entryway into the Internet research field. Librarians report that it supplements…

  2. Portal to the World: AIHEC Virtual Library Opens Doors for Native Research

    ERIC Educational Resources Information Center

    Kirby, Jane

    2004-01-01

    The Internet keeps growing at lightning speed. Now, "tribal college" students have a tool to assist them in locating accurate information quickly: the American Indian Higher Education Consortium (AIHEC) Virtual Library. The AIHEC Virtual Library provides a focused entryway into the Internet research field. Librarians report that it supplements…

  3. Factors Influencing Virtual Patron Satisfaction with Online Library Resources and Services

    ERIC Educational Resources Information Center

    Tyler, Katherine Mary

    2010-01-01

    College students are accessing virtual libraries whether they are on campus or learning from a distance. Academic institutions serving virtual patrons must remain focused on meeting the needs of those library users by continually examining their preferences, their searching behavior, and the information they seek. The purpose of this research was…

  4. Electronic Journals in Academic Libraries: A Comparison of ARL and Non-ARL Libraries.

    ERIC Educational Resources Information Center

    Shemberg, Marian; Grossman, Cheryl

    1999-01-01

    Describes a survey dealing with academic library provision of electronic journals and other electronic resources that compared ARL (Association of Research Libraries) members to non-ARL members. Highlights include full-text electronic journals; computers in libraries; online public access catalogs; interlibrary loan and electronic reserves; access…

  5. CycloPs: generating virtual libraries of cyclized and constrained peptides including nonnatural amino acids.

    PubMed

    Duffy, Fergal J; Verniere, Mélanie; Devocelle, Marc; Bernard, Elise; Shields, Denis C; Chubb, Anthony J

    2011-04-25

    We introduce CycloPs, software for the generation of virtual libraries of constrained peptides including natural and nonnatural commercially available amino acids. The software is written in the cross-platform Python programming language, and features include generating virtual libraries in one-dimensional SMILES and three-dimensional SDF formats, suitable for virtual screening. The stand-alone software is capable of filtering the virtual libraries using empirical measurements, including peptide synthesizability by standard peptide synthesis techniques, stability, and the druglike properties of the peptide. The software and accompanying Web interface is designed to enable the rapid generation of large, structurally diverse, synthesizable virtual libraries of constrained peptides quickly and conveniently, for use in virtual screening experiments. The stand-alone software, and the Web interface for evaluating these empirical properties of a single peptide, are available at http://bioware.ucd.ie .

  6. Electronic Health Record Meets Digital Library

    PubMed Central

    Humphreys, Betsy L.

    2000-01-01

    Linking the electronic health record to the digital library is a Web-era reformulation of the long-standing informatics goal of seamless integration of automated clinical data and relevant knowledge-based information to support informed decisions. The spread of the Internet, the development of the World Wide Web, and converging format standards for electronic health data and digital publications make effective linking increasingly feasible. Some existing systems link electronic health data and knowledge-based information in limited settings or limited ways. Yet many challenging informatics research problems remain to be solved before flexible and seamless linking becomes a reality and before systems become capable of delivering the specific piece of information needed at the time and place a decision must be made. Connecting the electronic health record to the digital library also requires positive resolution of important policy issues, including health data privacy, government envouragement of high-speed communications, electronic intellectual property rights, and standards for health data and for digital libraries. Both the research problems and the policy issues should be important priorities for the field of medical informatics. PMID:10984463

  7. Moving beyond Assumptions: The Use of Virtual Reference Data in an Academic Library

    ERIC Educational Resources Information Center

    Nolen, David S.; Powers, Amanda Clay; Zhang, Li; Xu, Yue; Cannady, Rachel E.; Li, Judy

    2012-01-01

    The Mississippi State University Libraries' Virtual Reference Service collected statistics about virtual reference usage. Analysis of the data collected by an entry survey from chat and e-mail transactions provided librarians with concrete information about what patron groups were the highest and lowest users of virtual reference services. These…

  8. The Intersection of Virtual Organizations and the Library: A Case Study

    ERIC Educational Resources Information Center

    Carlson, Jake; Yatcilla, Jane Kinkus

    2010-01-01

    The proliferation of virtual organizations is changing the nature and practice of research. These changes present a challenge to Libraries, as their traditional roles and services do not translate well to virtual organizations. However, virtual organizations also offer opportunities for librarians to participate in shaping the next generation of…

  9. Moving beyond Assumptions: The Use of Virtual Reference Data in an Academic Library

    ERIC Educational Resources Information Center

    Nolen, David S.; Powers, Amanda Clay; Zhang, Li; Xu, Yue; Cannady, Rachel E.; Li, Judy

    2012-01-01

    The Mississippi State University Libraries' Virtual Reference Service collected statistics about virtual reference usage. Analysis of the data collected by an entry survey from chat and e-mail transactions provided librarians with concrete information about what patron groups were the highest and lowest users of virtual reference services. These…

  10. The Role of Virtual Reference in Library Web Site Design: A Qualitative Source for Usage Data

    ERIC Educational Resources Information Center

    Powers, Amanda Clay; Shedd, Julie; Hill, Clay

    2011-01-01

    Gathering qualitative information about usage behavior of library Web sites is a time-consuming process requiring the active participation of patron communities. Libraries that collect virtual reference transcripts, however, hold valuable data regarding how the library Web site is used that could benefit Web designers. An analysis of virtual…

  11. The Role of Virtual Reference in Library Web Site Design: A Qualitative Source for Usage Data

    ERIC Educational Resources Information Center

    Powers, Amanda Clay; Shedd, Julie; Hill, Clay

    2011-01-01

    Gathering qualitative information about usage behavior of library Web sites is a time-consuming process requiring the active participation of patron communities. Libraries that collect virtual reference transcripts, however, hold valuable data regarding how the library Web site is used that could benefit Web designers. An analysis of virtual…

  12. The electronic-commerce-oriented virtual merchandise model

    NASA Astrophysics Data System (ADS)

    Fang, Xiaocui; Lu, Dongming

    2004-03-01

    Electronic commerce has been the trend of commerce activities. Providing with Virtual Reality interface, electronic commerce has better expressing capacity and interaction means. But most of the applications of virtual reality technology in EC, 3D model is only the appearance description of merchandises. There is almost no information concerned with commerce information and interaction information. This resulted in disjunction of virtual model and commerce information. So we present Electronic Commerce oriented Virtual Merchandise Model (ECVMM), which combined a model with commerce information, interaction information and figure information of virtual merchandise. ECVMM with abundant information provides better support to information obtainment and communication in electronic commerce.

  13. The Electronic Academic Library: Undergraduate Research Behavior in a Library Without Books

    ERIC Educational Resources Information Center

    Van Scoyoc, Anna M.; Cason, Caroline

    2006-01-01

    This study examines undergraduate students' research habits in a strictly electronic library environment at a large public university. Unlike most information commons, the campus' electronic library is not housed within a traditional library space and provides access to electronic research materials exclusively. This study finds that undergraduate…

  14. The National Electronic Library: A Guide to the Future for Library Managers. The Greenwood Library Management Collection.

    ERIC Educational Resources Information Center

    Pitkin, Gary M., Ed.

    As a reference guide for library professionals, this volume helps librarians prepare for the future in the growing electronic environment by examining the historical and theoretical background of the National Electronic Library and assessing the role of libraries in the past, present, and future. The book is divided in two sections: "The…

  15. The National Electronic Library: A Guide to the Future for Library Managers. The Greenwood Library Management Collection.

    ERIC Educational Resources Information Center

    Pitkin, Gary M., Ed.

    As a reference guide for library professionals, this volume helps librarians prepare for the future in the growing electronic environment by examining the historical and theoretical background of the National Electronic Library and assessing the role of libraries in the past, present, and future. The book is divided in two sections: "The…

  16. Marketing CD-ROM and Other Electronic Library Services.

    ERIC Educational Resources Information Center

    Cihak, Herb

    1997-01-01

    Argues that information professionals should market services to ensure success for their libraries. Describes marketing strategies used by the University of Kentucky College of Law Library to promote electronic library services: CD-ROM placement, CD-ROM and Internet workshops, instruction guides, faculty Web pages, online tours, electronic mail,…

  17. NASA Electronic Library System (NELS) optimization

    NASA Technical Reports Server (NTRS)

    Pribyl, William L.

    1993-01-01

    This is a compilation of NELS (NASA Electronic Library System) Optimization progress/problem, interim, and final reports for all phases. The NELS database was examined, particularly in the memory, disk contention, and CPU, to discover bottlenecks. Methods to increase the speed of NELS code were investigated. The tasks included restructuring the existing code to interact with others more effectively. An error reporting code to help detect and remove bugs in the NELS was added. Report writing tools were recommended to integrate with the ASV3 system. The Oracle database management system and tools were to be installed on a Sun workstation, intended for demonstration purposes.

  18. Approaches to virtual screening and screening library selection.

    PubMed

    Wildman, Scott A

    2013-01-01

    The ease of access to virtual screening (VS) software in recent years has resulted in a large increase in literature reports. Over 300 publications in the last year report the use of virtual screening techniques to identify new chemical matter or present the development of new virtual screening techniques. The increased use is accompanied by a corresponding increase in misuse and misinterpretation of virtual screening results. This review aims to identify many of the common difficulties associated with virtual screening and allow researchers to better assess the reliability of their virtual screening effort.

  19. Virtual reflections in electronic acoustic architecture

    NASA Astrophysics Data System (ADS)

    van Munster, Bjorn

    2005-09-01

    In the era of the ancient Greeks and Byzantines, the first attempts for increasing reverberation time are noted. In the 1950s, the Ambiophonic system accomplished this by means of an electronic device, for the first time. The early systems only increased the reverberation time by delaying the picked-up reverberation. With the introduction of multichannel feedback-based systems, the reverberation level also could be increased. Later, it was understood that it was important to also fill in the missing reflections, address reflection density, frequency dependence, etc. This resulted in the development of the SIAP concept. Current DSP technology led to the development of a processor whereby density, length, level, and the frequency content can be controlled for different areas in the same room or different rooms, leading to the concept of the acoustic server. electronic acoustic architecture has become the current state-of-the-art approach for solving acoustic deficiencies in, among others, rehearsal rooms, theaters, churches, and multipurpose venues. Incorporation of complementary passive acoustic solutions provides an optimum solution for all room problems. This paper discusses the utilization of virtual reflections in the new approach of electronic acoustic architecture for different environments. Measurements performed in the Sejong Performing Arts Centre, Seoul, South Korea, show the power of this approach.

  20. Relevance Judging, Evaluation, and Decision Making in Virtual Libraries: A Descriptive Study.

    ERIC Educational Resources Information Center

    Fitzgerald, Mary Ann; Galloway, Chad

    2001-01-01

    Describes a study that investigated the cognitive processes undergraduates used to select information while using a virtual library, GALILEO (Georgia Library Learning Online). Discusses higher order thinking processes, relevance judging, evaluation (critical thinking), decision making, reasoning involving documents, relevance-related reasoning,…

  1. Relevance Judging, Evaluation, and Decision Making in Virtual Libraries: A Descriptive Study.

    ERIC Educational Resources Information Center

    Fitzgerald, Mary Ann; Galloway, Chad

    2001-01-01

    Describes a study that investigated the cognitive processes undergraduates used to select information while using a virtual library, GALILEO (Georgia Library Learning Online). Discusses higher order thinking processes, relevance judging, evaluation (critical thinking), decision making, reasoning involving documents, relevance-related reasoning,…

  2. Screening of a virtual mirror-image library of natural products.

    PubMed

    Noguchi, Taro; Oishi, Shinya; Honda, Kaori; Kondoh, Yasumitsu; Saito, Tamio; Ohno, Hiroaki; Osada, Hiroyuki; Fujii, Nobutaka

    2016-06-08

    We established a facile access to an unexplored mirror-image library of chiral natural product derivatives using d-protein technology. In this process, two chemical syntheses of mirror-image substances including a target protein and hit compound(s) allow the lead discovery from a virtual mirror-image library without the synthesis of numerous mirror-image compounds.

  3. Improving the Virtual Reference Experience: How Closely Do Academic Libraries Adhere to RUSA Guidelines?

    ERIC Educational Resources Information Center

    Platt, Jessica; Benson, Pete

    2010-01-01

    The purpose of this study was to measure the degree to which academic libraries or library staff members throughout the United States adhere to the Guidelines for Virtual Reference Services provided by the Reference & User Services Association (RUSA). The results of the study were analyzed to identify specific areas where improvement is needed…

  4. Virtually the Same: Comparing the Effectiveness of Online versus In-Person Library Tours

    ERIC Educational Resources Information Center

    Burhanna, Kenneth J.; Voelker, Tammy J. Eschedor; Gedeon, Julie A.

    2008-01-01

    The use of virtual or Web-based tours is on the rise in academic libraries, but with the loss of face-to-face contact and direct experience with the library's physical spaces, questions abound about this format's efficacy. Do online tour experiences measure up to those of a guided, face-to-face tour? Do online tours help mold students' perceptions…

  5. Virtually the Same: Comparing the Effectiveness of Online versus In-Person Library Tours

    ERIC Educational Resources Information Center

    Burhanna, Kenneth J.; Voelker, Tammy J. Eschedor; Gedeon, Julie A.

    2008-01-01

    The use of virtual or Web-based tours is on the rise in academic libraries, but with the loss of face-to-face contact and direct experience with the library's physical spaces, questions abound about this format's efficacy. Do online tour experiences measure up to those of a guided, face-to-face tour? Do online tours help mold students' perceptions…

  6. Building the electronic health sciences library for the twenty-first century: the Galter Library experience.

    PubMed

    Shedlock, J; Barkey, D C; Ross, F

    1996-01-01

    Constructing home pages for World-Wide Web access has become a major activity in academic health sciences libraries. At the Northwestern University, Galter Health Sciences Library staff are creating the library's new health information system using Web resources and integrating them with existing library systems-NUmed (OVID MEDLINE) and LUIS/NUcat (NOTIS). Development of Web pages, including selection and organization of electronic information, has become the building process for the electronic library. Selection, organization, design, and construction are important factors in the creation of an efficient and useful information system. Using resources like the World-Wide Web and tools like Netscape, library staff are designing an interface, defining policies and guidelines, and creating the tools that will give users easy access to local and international electronic, scholarly information resources. In this paper, the process used at Northwestern is shown as a model of an electronic health sciences library for the twenty-first century.

  7. Similarity based virtual screening: a tool for targeted library design.

    PubMed

    Alvesalo, Joni K O; Siiskonen, Antti; Vainio, Mikko J; Tammela, Päivi S M; Vuorela, Pia M

    2006-04-06

    High throughput screening drug discovery utilizes large and expensive compound libraries. As an alternative, a smaller targeted library can be constructed with the aid of the 3D structure of the target molecule. We used the X-ray crystal structure of a protein homologous to the selected target in creation of a small focused library and evaluated inhibition potential of this library against Chlamydia pneumoniae, a common pathogen recently linked to atherosclerosis and risk of myocardial infarction.

  8. The CECAM Electronic Structure Library: community-driven development of software libraries for electronic structure simulations

    NASA Astrophysics Data System (ADS)

    Oliveira, Micael

    The CECAM Electronic Structure Library (ESL) is a community-driven effort to segregate shared pieces of software as libraries that could be contributed and used by the community. Besides allowing to share the burden of developing and maintaining complex pieces of software, these can also become a target for re-coding by software engineers as hardware evolves, ensuring that electronic structure codes remain at the forefront of HPC trends. In a series of workshops hosted at the CECAM HQ in Lausanne, the tools and infrastructure for the project were prepared, and the first contributions were included and made available online (http://esl.cecam.org). In this talk I will present the different aspects and aims of the ESL and how these can be useful for the electronic structure community.

  9. Application of new technologies in the virtual library: Seminars in Turkey, Portugal, and Spain

    NASA Technical Reports Server (NTRS)

    Hunter, Judy F.; Cotter, Gladys A.

    1994-01-01

    This paper focuses on the technologies that are available today to support the concept of a virtual library. The concept of a 'virtual library' or a 'library without walls' is meant to convey the idea that information in any format should be available to the end-user from the desktop as if it were located on the local workstation. Discussed here are the background, trends, technology enablers, end-user requirements, and the NASA Access Mechanism (NAM) system, one example of how it is possible to apply existing technologies to the client server architecture to logically centralize geographically distributed applications and information.

  10. Electronic Mail Reference Services in the Public Library.

    ERIC Educational Resources Information Center

    Garnsey, Beth A.; Powell, Ronald R.

    2000-01-01

    Describes results of an exploratory survey that examined public library electronic mail reference services and the patrons who used them. Discusses results of print questionnaires and Web-based questionnaires that investigated user satisfaction and classified email reference questions received by public libraries. Library questionnaire and web…

  11. From Vision to Reality: Implementing the Distributed Electronic Library.

    ERIC Educational Resources Information Center

    Troll, Denise A.; Richards, Barbara G.

    1992-01-01

    Describes the design and development of the Mercury Electronic Library Project at Carnegie Mellon University that resulted in a library information system that provides access to the library's online catalog as well as to other databases. The distributed architecture of the system is explained, and future plans are discussed. (two references) (LRW)

  12. An Electronic Library Grows: The Gateway to Cornell University's Albert R. Mann Library.

    ERIC Educational Resources Information Center

    Barnes, Susan J.

    1993-01-01

    Summarizes users' opinions of a networked electronic library at Cornell University's Mann Library as part of the planning process for a major redesign. The system's impact on library collection development, preservation, technical services, information services and delivery, instruction, and computer support are described; and plans for library…

  13. Transforming Libraries: Issues and Innovations in Electronic Reserves. Transforming Libraries Series. SPEC Kit 217.

    ERIC Educational Resources Information Center

    Soete, George J.

    This volume is the pilot issue of the "Transforming Libraries" series, a quarterly subseries of SPEC (the Systems and Procedures Exchange Center of the Association of Research Libraries). Each issue will focus on a different application or aspect of library technology. This issue discusses electronic reserves. It is divided into five…

  14. Design of focused and restrained subsets from extremely large virtual libraries.

    PubMed

    Jamois, Eric A; Lin, Chien T; Waldman, Marvin

    2003-11-01

    With the current and ever-growing offering of reagents along with the vast palette of organic reactions, virtual libraries accessible to combinatorial chemists can reach sizes of billions of compounds or more. Extracting practical size subsets for experimentation has remained an essential step in the design of combinatorial libraries. A typical approach to computational library design involves enumeration of structures and properties for the entire virtual library, which may be unpractical for such large libraries. This study describes a new approach termed as on the fly optimization (OTFO) where descriptors are computed as needed within the subset optimization cycle and without intermediate enumeration of structures. Results reported herein highlight the advantages of coupling an ultra-fast descriptor calculation engine to subset optimization capabilities. We also show that enumeration of properties for the entire virtual library may not only be unpractical but also wasteful. Successful design of focused and restrained subsets can be achieved while sampling only a small fraction of the virtual library. We also investigate the stability of the method and compare results obtained from simulated annealing (SA) and genetic algorithms (GA).

  15. The Virtual Naval Hospital: the digital library as knowledge management tool for nomadic patrons*

    PubMed Central

    D'Alessandro, Michael P.; D'Alessandro, Donna M.; Bakalar, Richard S.; Ashley, Denis E.; Hendrix, Mary J. C.

    2005-01-01

    Objective: To meet the information needs of isolated primary care providers and their patients in the US Navy, a digital health sciences library, the Virtual Naval Hospital, was created through a unique partnership between academia and government. Methods: The creation of the digital library was heavily influenced by the principles of user-centered design and made allowances for the nomadic nature of the digital library's patrons and the heterogeneous access they have to Internet bandwidth. Results: The result is a digital library that has been in operation since 1997, continues to expand in size, is heavily used, and is highly regarded by its patrons. Conclusions: The digital library is dedicated to delivering the right information at the right time to the right person so the right decision can be made, and therefore the Virtual Naval Hospital functions as a knowledge-management system for the US Navy Bureau of Medicine and Surgery. PMID:15685269

  16. The Local Electronic Library: Science Fiction or the Real Future?

    ERIC Educational Resources Information Center

    Cuadra, Carlos A.

    1983-01-01

    Addresses the question of whether interest in downloading into local electronic libraries is a reflection of user needs or is being generated by those who have something to sell. Growth of online services, growth of local computer capacity, purposes of a local electronic library, and sources of data are highlighted. (EJS)

  17. The Local Electronic Library: Science Fiction or the Real Future?

    ERIC Educational Resources Information Center

    Cuadra, Carlos A.

    1983-01-01

    Addresses the question of whether interest in downloading into local electronic libraries is a reflection of user needs or is being generated by those who have something to sell. Growth of online services, growth of local computer capacity, purposes of a local electronic library, and sources of data are highlighted. (EJS)

  18. How Should Privacy Be Protected in the Electronic Library?

    ERIC Educational Resources Information Center

    Balas, Janet L.

    2001-01-01

    Discusses privacy issues related to electronic libraries. Highlights include finding guidance and information on the Web, including the American Library Association, Center for Democracy and Technology, and the Electronic Privacy Information Center; legal responsibilities in maintaining privacy rights of patrons who access the Internet; and…

  19. Web Access to Electronic Journals and Databases in ARL Libraries

    ERIC Educational Resources Information Center

    Caudle, Dana M.; Schmitz, Cecilia M.

    2007-01-01

    Libraries are investing heavily in an increasing number of electronic journals and providing access to them through their websites. We set out to determine if ARL academic libraries offer the same options on their websites to access electronic journals and databases. Using a checklist, we evaluated the websites for the presence of A-Z lists, links…

  20. Web Access to Electronic Journals and Databases in ARL Libraries

    ERIC Educational Resources Information Center

    Caudle, Dana M.; Schmitz, Cecilia M.

    2007-01-01

    Libraries are investing heavily in an increasing number of electronic journals and providing access to them through their websites. We set out to determine if ARL academic libraries offer the same options on their websites to access electronic journals and databases. Using a checklist, we evaluated the websites for the presence of A-Z lists, links…

  1. Virtual Communities in Europe: The European Library Approach

    ERIC Educational Resources Information Center

    Stigter, Fleur

    2009-01-01

    Purpose: The purpose of this paper is to provide an overview of The Bridging Worlds Conference which was held in October 2008 in Singapore. Design/methodology/approach: One of the main topics the National Library Board of Singapore, the organising party, wished to address was the roles cultural institutions, such as libraries, may play in…

  2. Virtual Communities in Europe: The European Library Approach

    ERIC Educational Resources Information Center

    Stigter, Fleur

    2009-01-01

    Purpose: The purpose of this paper is to provide an overview of The Bridging Worlds Conference which was held in October 2008 in Singapore. Design/methodology/approach: One of the main topics the National Library Board of Singapore, the organising party, wished to address was the roles cultural institutions, such as libraries, may play in…

  3. Management Matters. Virtual School Library Media Center Management Manual

    ERIC Educational Resources Information Center

    Pappas, Marjorie L.

    2005-01-01

    In this article, the author describes a management manual she maintained while working as a school library media specialist. She started the manual when she was a student in the organization and administration course in the library science program and kept it current with information gleaned from conferences, workshops, and networking with other…

  4. Rambrain - a library for virtually extending physical memory

    NASA Astrophysics Data System (ADS)

    Imgrund, Maximilian; Arth, Alexander

    2017-08-01

    We introduce Rambrain, a user space library that manages memory consumption of your code. Using Rambrain you can overcommit memory over the size of physical memory present in the system. Rambrain takes care of temporarily swapping out data to disk and can handle multiples of the physical memory size present. Rambrain is thread-safe, OpenMP and MPI compatible and supports Asynchronous IO. The library was designed to require minimal changes to existing programs and to be easy to use.

  5. Maggie's Place III: An Electronic Library Revisited.

    ERIC Educational Resources Information Center

    Larsen, Gitte

    1988-01-01

    Describes the services offered by Maggie's Place, one of the first fully automated libraries in the world. Topics covered include the online catalog; automated technical processes; dial-up access for patrons; community information databases; and online access to U.S. and international library network services. (five references) (CLB)

  6. Information Access through Electronic Databases for Rural Public Libraries.

    ERIC Educational Resources Information Center

    Canepi, Kitti

    1997-01-01

    To compile a list of recommended electronic databases for rural libraries, public library patron questions received by the Arizona State Reference Center were searched on ten databases. The results indicated Books in Print, Magazine Database, ABI/INFORM, Public Affairs Information System (PAIS), and Government Printing Office (GPO) Publications…

  7. Integrating Print and Electronic Resources: Joyner Library's "Pirate Source"

    ERIC Educational Resources Information Center

    Nall, Clark; Lewis, Janice Steed

    2005-01-01

    Valuable information in print is often neglected because of the rapid proliferation of electronic resources and the bias of many library users against print sources. At Joyner Library, it was decided to construct an interactive subject guide database that included resources in all formats to offer users a convenient starting point for research and…

  8. Rights Management and Security in the Electronic Library.

    ERIC Educational Resources Information Center

    Anderson, Laura Challman; Lotspiech, Jeffrey B.

    1995-01-01

    Discusses collaborative efforts by the Institute for Scientific Information (ISI) and the IBM Digital Library Group in creating techniques to ensure information integrity, journal article authenticity, user confidentiality, management of copyright, and general security in electronic libraries. Also describes the rights management and security…

  9. A Web-Based Electronic Book (e-book) Library: The netLibrary Model.

    ERIC Educational Resources Information Center

    Connaway, Lynn Silipigni

    2001-01-01

    Identifies elements that are important for academic libraries to use in evaluating electronic books, including content; acquisition and collection development; software and hardware standards and protocols; digital rights management; access; archiving; privacy; the market and pricing; and enhancements and ideal features. Describes netLibrary, a…

  10. A Web-Based Electronic Book (e-book) Library: The netLibrary Model.

    ERIC Educational Resources Information Center

    Connaway, Lynn Silipigni

    2001-01-01

    Identifies elements that are important for academic libraries to use in evaluating electronic books, including content; acquisition and collection development; software and hardware standards and protocols; digital rights management; access; archiving; privacy; the market and pricing; and enhancements and ideal features. Describes netLibrary, a…

  11. Touring by Design: Using Information Architecture To Create a Virtual Library Tour.

    ERIC Educational Resources Information Center

    Kittelson, Pat; Jones, Sarah

    2002-01-01

    Describes the development of a Web-based virtual tour of the University of Otago (New Zealand) science library. Highlights include information literacy learning outcomes; information architecture, including information organization and navigation; integrating the tour into course work; and evaluation results. (LRW)

  12. Going Social at Vancouver Public Library: What the Virtual Branch Did Next

    ERIC Educational Resources Information Center

    Cahill, Kay

    2011-01-01

    Purpose: The purpose of this paper is to follow up on the 2009 publication "Building a virtual branch at Vancouver Public Library (VPL) using Web 2.0 tools" and to explore the work that VPL has been doing in the social media space over the past two years. Design/methodology/approach: Following the launch of its new web site in 2008,…

  13. Building a Virtual Branch at Vancouver Public Library Using Web 2.0 Tools

    ERIC Educational Resources Information Center

    Cahill, Kay

    2009-01-01

    Purpose: The purpose of this paper is to demonstrate the work undertaken by Vancouver Public Library (VPL) in an effort to convert its website into a true virtual branch, both through the functionality of the website itself and by extending its web presence on to external social networking sites. Design/methodology/approach: VPL worked with its…

  14. Institutional, Public and Individual Learning Dynamics of the Andy Holt Virtual Library.

    ERIC Educational Resources Information Center

    Peckham, Robert

    The Andy Holt Virtual Library, with a focus on the Humanities and Fine Arts, is free and open to the public, though designed to serve the learning communities within the College of Humanities and Fine Arts at the University of Tennessee-Martin (UT). It also plays a resource role in UT's New College and the Tennessee Governors School for the…

  15. OKSALE: Building a Culturally Responsive Virtual Library of Education Resources for a Tribal College.

    ERIC Educational Resources Information Center

    Roy, Loriene

    2002-01-01

    Describes the development of a virtual library of education resources for preservice teachers at a tribal college, the Northwest Indian College, to help increase the number of Native American teachers. Discusses content, including links and pathfinders; graphics and design that are culturally sensitive and appropriate; and communication and…

  16. Going Social at Vancouver Public Library: What the Virtual Branch Did Next

    ERIC Educational Resources Information Center

    Cahill, Kay

    2011-01-01

    Purpose: The purpose of this paper is to follow up on the 2009 publication "Building a virtual branch at Vancouver Public Library (VPL) using Web 2.0 tools" and to explore the work that VPL has been doing in the social media space over the past two years. Design/methodology/approach: Following the launch of its new web site in 2008,…

  17. A Survey and Empirical Study of Virtual Reference Service in Academic Libraries

    ERIC Educational Resources Information Center

    Mu, Xiangming; Dimitroff, Alexandra; Jordan, Jeanette; Burclaff, Natalie

    2011-01-01

    Virtual Reference Services (VRS) have high user satisfaction. The main problem is its low usage. We surveyed 100 academic library web sites to understand how VRS are presented. We then conducted a usability study to further test an active VRS model regarding its effectiveness.

  18. Building a Virtual Branch at Vancouver Public Library Using Web 2.0 Tools

    ERIC Educational Resources Information Center

    Cahill, Kay

    2009-01-01

    Purpose: The purpose of this paper is to demonstrate the work undertaken by Vancouver Public Library (VPL) in an effort to convert its website into a true virtual branch, both through the functionality of the website itself and by extending its web presence on to external social networking sites. Design/methodology/approach: VPL worked with its…

  19. A Survey and Empirical Study of Virtual Reference Service in Academic Libraries

    ERIC Educational Resources Information Center

    Mu, Xiangming; Dimitroff, Alexandra; Jordan, Jeanette; Burclaff, Natalie

    2011-01-01

    Virtual Reference Services (VRS) have high user satisfaction. The main problem is its low usage. We surveyed 100 academic library web sites to understand how VRS are presented. We then conducted a usability study to further test an active VRS model regarding its effectiveness.

  20. OKSALE: Building a Culturally Responsive Virtual Library of Education Resources for a Tribal College.

    ERIC Educational Resources Information Center

    Roy, Loriene

    2002-01-01

    Describes the development of a virtual library of education resources for preservice teachers at a tribal college, the Northwest Indian College, to help increase the number of Native American teachers. Discusses content, including links and pathfinders; graphics and design that are culturally sensitive and appropriate; and communication and…

  1. Template-based combinatorial enumeration of virtual compound libraries for lipids.

    PubMed

    Sud, Manish; Fahy, Eoin; Subramaniam, Shankar

    2012-09-25

    A variety of software packages are available for the combinatorial enumeration of virtual libraries for small molecules, starting from specifications of core scaffolds with attachments points and lists of R-groups as SMILES or SD files. Although SD files include atomic coordinates for core scaffolds and R-groups, it is not possible to control 2-dimensional (2D) layout of the enumerated structures generated for virtual compound libraries because different packages generate different 2D representations for the same structure. We have developed a software package called LipidMapsTools for the template-based combinatorial enumeration of virtual compound libraries for lipids. Virtual libraries are enumerated for the specified lipid abbreviations using matching lists of pre-defined templates and chain abbreviations, instead of core scaffolds and lists of R-groups provided by the user. 2D structures of the enumerated lipids are drawn in a specific and consistent fashion adhering to the framework for representing lipid structures proposed by the LIPID MAPS consortium. LipidMapsTools is lightweight, relatively fast and contains no external dependencies. It is an open source package and freely available under the terms of the modified BSD license.

  2. Virtual screening and optimization of Type II inhibitors of JAK2 from a natural product library.

    PubMed

    Ma, Dik-Lung; Chan, Daniel Shiu-Hin; Wei, Guo; Zhong, Hai-Jing; Yang, Hui; Leung, Lai To; Gullen, Elizabeth A; Chiu, Pauline; Cheng, Yung-Chi; Leung, Chung-Hang

    2014-11-21

    Amentoflavone has been identified as a JAK2 inhibitor by structure-based virtual screening of a natural product library. In silico optimization using the DOLPHIN model yielded analogues with enhanced potency against JAK2 activity and HCV activity in cellulo. Molecular modeling and kinetic experiments suggested that the analogues may function as Type II inhibitors of JAK2.

  3. Virtual Journal Room: MSU Libraries Table of Contents Service

    ERIC Educational Resources Information Center

    Sutherland, Michael; Clark, Jason

    2009-01-01

    Montana State University (MSU) Libraries (where the authors serve as web services librarian and digital initiatives librarian, respectively) is perhaps unique because it has no current periodicals room due to lack of space. As a result, finding current journals for research is difficult for its patrons, who do not always know how or where to…

  4. Virtual Journal Room: MSU Libraries Table of Contents Service

    ERIC Educational Resources Information Center

    Sutherland, Michael; Clark, Jason

    2009-01-01

    Montana State University (MSU) Libraries (where the authors serve as web services librarian and digital initiatives librarian, respectively) is perhaps unique because it has no current periodicals room due to lack of space. As a result, finding current journals for research is difficult for its patrons, who do not always know how or where to…

  5. Browsing Your Virtual Library: The Case of Expanding Universe.

    ERIC Educational Resources Information Center

    Daniels, Wayne; Enright, Jeanne; Mackenzie, Scott

    1997-01-01

    Describes "Expanding Universe: a classified search tool for amateur astronomy," a Web site maintained by the Metropolitan Toronto Reference Library which uses a modified form of the Dewey Decimal Classification to organize a large file of astronomy hotlinks. Highlights include structure, HTML coding, design requirements, and future…

  6. Browsing Your Virtual Library: The Case of Expanding Universe.

    ERIC Educational Resources Information Center

    Daniels, Wayne; Enright, Jeanne; Mackenzie, Scott

    1997-01-01

    Describes "Expanding Universe: a classified search tool for amateur astronomy," a Web site maintained by the Metropolitan Toronto Reference Library which uses a modified form of the Dewey Decimal Classification to organize a large file of astronomy hotlinks. Highlights include structure, HTML coding, design requirements, and future…

  7. Comparative analysis of machine learning methods in ligand-based virtual screening of large compound libraries.

    PubMed

    Ma, Xiao H; Jia, Jia; Zhu, Feng; Xue, Ying; Li, Ze R; Chen, Yu Z

    2009-05-01

    Machine learning methods have been explored as ligand-based virtual screening tools for facilitating drug lead discovery. These methods predict compounds of specific pharmacodynamic, pharmacokinetic or toxicological properties based on their structure-derived structural and physicochemical properties. Increasing attention has been directed at these methods because of their capability in predicting compounds of diverse structures and complex structure-activity relationships without requiring the knowledge of target 3D structure. This article reviews current progresses in using machine learning methods for virtual screening of pharmacodynamically active compounds from large compound libraries, and analyzes and compares the reported performances of machine learning tools with those of structure-based and other ligand-based (such as pharmacophore and clustering) virtual screening methods. The feasibility to improve the performance of machine learning methods in screening large libraries is discussed.

  8. Electronic Government Information and the Depository Library Program: Paradise Found?

    ERIC Educational Resources Information Center

    Dugan, Robert E.; Cheverie, Joan F.

    1992-01-01

    The trend in the 1980s to provide an increasingly larger amounts of government information in electronic formats has led to concerns regarding the inclusion of electronic items in the depository library program (DLP). Inclusion of electronic formats in the DLP provides increased public access but also poses technical problems for the depository…

  9. Your Library Goes Virtual: Promoting Reading and Supporting Research

    ERIC Educational Resources Information Center

    Church, Audrey

    2006-01-01

    According to a November 2004 Pew Internet and American Life Project survey, "87% of those between the ages of 12 and 17 are online...and half of them say they go online every day" ("Teens Forge" 1). They prefer the Internet to traditional libraries because they consider the Internet to be easier to use, more convenient, open 24/7, and full of more…

  10. The Management of Change in Electronic Libraries.

    ERIC Educational Resources Information Center

    Akeroyd, John

    Libraries are in a process of fundamental change brought about by radical changes in technology. This paper charts the changes that have taken place over the years and makes some assumptions as to how the future will look. Barriers to increased use of technology are analyzed and detailed, including: lack of uniformity in search systems; the…

  11. A Trial Virtual Library: Renovation and Innovation at Great Basin College.

    ERIC Educational Resources Information Center

    Karr, Juanita

    2000-01-01

    Describes how librarians coped in temporary quarters in a warehouse and with a drastically reduced circulating and reference collection when Great Basin College's library closed temporarily due to renovation. Discusses how the experience led to innovations in the integration of electronic databases into the renovated library. (VWC)

  12. Pfizer Global Virtual Library (PGVL): a chemistry design tool powered by experimentally validated parallel synthesis information.

    PubMed

    Hu, Qiyue; Peng, Zhengwei; Sutton, Scott C; Na, Jim; Kostrowicki, Jaroslav; Yang, Bo; Thacher, Thomas; Kong, Xianjun; Mattaparti, Sarathy; Zhou, Joe Zhongxiang; Gonzalez, Javier; Ramirez-Weinhouse, Michele; Kuki, Atsuo

    2012-11-12

    An unprecedented amount of parallel synthesis information was accumulated within Pfizer over the past 12 years. This information was captured by an informatics tool known as PGVL (Pfizer Global Virtual Library). PGVL was used for many aspects of drug discovery including automated reactant mining and reaction product formation to build a synthetically feasible virtual compound collection. In this report, PGVL is discussed in detail. The chemistry information within PGVL has been used to extract synthesis and design information using an intuitive desktop Graphic User Interface, PGVL Hub. Several real-case examples of PGVL are also presented.

  13. The Use of Electronic Book Theft Detection Systems in Libraries.

    ERIC Educational Resources Information Center

    Witt, Thomas B.

    1996-01-01

    Although electronic book theft detection systems can be a deterrent to library material theft, no electronic system is foolproof, and a total security program is necessary to ensure collection security. Describes how book theft detection systems work, their effectiveness, and the problems inherent in technology. A total security program considers…

  14. Institutional Challenges to Increased Library Provision of Electronic Materials

    ERIC Educational Resources Information Center

    Johnson, Gareth J.

    2007-01-01

    The University of York is among the top universities in the United Kingdom, yet has not adopted all manner of electronic media. The University Library attempts to meet the demands placed upon it by its academic and student users for electronic media of all kinds, while working within a sometimes frame work that does not encourage exploitation of…

  15. Institutional Challenges to Increased Library Provision of Electronic Materials

    ERIC Educational Resources Information Center

    Johnson, Gareth J.

    2007-01-01

    The University of York is among the top universities in the United Kingdom, yet has not adopted all manner of electronic media. The University Library attempts to meet the demands placed upon it by its academic and student users for electronic media of all kinds, while working within a sometimes frame work that does not encourage exploitation of…

  16. Door to the World: Iowa Libraries and the Electronic Information Highway.

    ERIC Educational Resources Information Center

    Iowa State Library, Des Moines.

    This document examines the roles, issues, and needs of Iowa libraries in the age of the electronic information highway based on the responses of library practitioners to a request from the State Library of Iowa to briefly address these concerns. The report begins with brief discussions of traditional library services; electronic library services;…

  17. Electronic Communication Training: Reconciling Gaps Created by the Virtual Office.

    ERIC Educational Resources Information Center

    Hartman, Jackie L. Jankovich; Ogden, Brenda K.; Geroy, Gary D.

    2001-01-01

    Discusses gaps between traditional and virtual organizational environments and suggests that electronic communication training is necessary to lessen the chance for unclear messages, to enhance faceless interactions, and avoid communication overload. Topics include interpersonal skills; verbal and nonverbal communication competencies; written…

  18. The virtual library in action: Collaborative international control of high-energy physics pre-print

    SciTech Connect

    Kreitz, P.A.; Addis, L.; Galic, H.; Johnson, T.

    1996-02-01

    This paper will discuss how control of the grey literature in high-energy physics pre-prints developed through a collaborative effort of librarians and physicists. It will highlight the critical steps in the development process and describe one model of a rapidly evolving virtual library for high-energy physics information. In conclusion, this paper will extend this physics model to other areas of grey literature management.

  19. Virtualizing the p-ANAPL Library: A Step towards Drug Discovery from African Medicinal Plants

    PubMed Central

    Fotso, Ghislain W.; Andrae-Marobela, Kerstin; Bezabih, Merhatibeb; Ndom, Jean Claude; Ngadjui, Bonaventure T.; Ogundaini, Abiodun O.; Abegaz, Berhanu M.; Meva’a, Luc Mbaze

    2014-01-01

    Background Natural products play a key role in drug discovery programs, both serving as drugs and as templates for the synthesis of drugs, even though the quantities and availabilities of samples for screening are often limitted. Experimental approach A current collection of physical samples of > 500 compound derived from African medicinal plants aimed at screening for drug discovery has been made by donations from several researchers from across the continent to be directly available for drug discovery programs. A virtual library of 3D structures of compounds has been generated and Lipinski’s “Rule of Five” has been used to evaluate likely oral availability of the samples. Results A majority of the compound samples are made of flavonoids and about two thirds (2/3) are compliant to the “Rule of Five”. The pharmacological profiles of thirty six (36) selected compounds in the collection have been discussed. Conclusions and implications The p-ANAPL library is the largest physical collection of natural products derived from African medicinal plants directly available for screening purposes. The virtual library is also available and could be employed in virtual screening campaigns. PMID:24599120

  20. Construction of a virtual combinatorial library using SMILES strings to discover potential structure-diverse PPAR modulators.

    PubMed

    Liao, Chenzhong; Liu, Bing; Shi, Leming; Zhou, Jiaju; Lu, Xian-Ping

    2005-07-01

    Based on the structural characters of PPAR modulators, a virtual combinatorial library containing 1226,625 compounds was constructed using SMILES strings. Selected ADME filters were employed to compel compounds having poor drug-like properties from this library. This library was converted to sdf and mol2 files by CONCORD 4.0, and was then docked to PPARgamma by DOCK 4.0 to identify new chemical entities that may be potential drug leads against type 2 diabetes and other metabolic diseases. The method to construct virtual combinatorial library using SMILES strings was further visualized by Visual Basic.net that can facilitate the needs of generating other type virtual combinatorial libraries.

  1. The Virtual Hospital: experiences in creating and sustaining a digital library.

    PubMed Central

    D'Alessandro, M P; Galvin, J R; Erkonen, W E; Choi, T A; Lacey, D L; Colbert, S I

    1998-01-01

    A university and its faculty encompass a wealth of content, which is often freely supplied to commercial publishers who profit from it. Emerging digital library technology holds promise for allowing the creation of digital libraries and digital presses that can allow faculty and universities to bypass commercial publishers, retain control of their content, and distribute it directly to users, allowing the university and faculty to better serve their constituencies. The purpose of this paper is to show how this can be done. A methodology for overcoming the technical, social, political, and economic barriers involved in creating, distributing and organizing a digital library was developed, implemented, and refined over seven years. Over the seven years, 120 textbooks and booklets were placed in the Virtual Hospital digital library, from 159 authors in twenty-nine departments and four colleges at The University of Iowa. The digital library received extensive use by individuals around the world. A new paradigm for academic publishing was created, involving a university and faculty owned peer reviewed digital press implemented using digital library technology. The concept has been embraced by The University of Iowa, and it has pledged to sustain the digital press in order to allow. The University of Iowa to fulfill its mission of creating, organizing, and disseminating information better. PMID:9803300

  2. The Virtual Hospital: experiences in creating and sustaining a digital library.

    PubMed

    D'Alessandro, M P; Galvin, J R; Erkonen, W E; Choi, T A; Lacey, D L; Colbert, S I

    1998-10-01

    A university and its faculty encompass a wealth of content, which is often freely supplied to commercial publishers who profit from it. Emerging digital library technology holds promise for allowing the creation of digital libraries and digital presses that can allow faculty and universities to bypass commercial publishers, retain control of their content, and distribute it directly to users, allowing the university and faculty to better serve their constituencies. The purpose of this paper is to show how this can be done. A methodology for overcoming the technical, social, political, and economic barriers involved in creating, distributing and organizing a digital library was developed, implemented, and refined over seven years. Over the seven years, 120 textbooks and booklets were placed in the Virtual Hospital digital library, from 159 authors in twenty-nine departments and four colleges at The University of Iowa. The digital library received extensive use by individuals around the world. A new paradigm for academic publishing was created, involving a university and faculty owned peer reviewed digital press implemented using digital library technology. The concept has been embraced by The University of Iowa, and it has pledged to sustain the digital press in order to allow. The University of Iowa to fulfill its mission of creating, organizing, and disseminating information better.

  3. SYBYL line notation (SLN): a single notation to represent chemical structures, queries, reactions, and virtual libraries.

    PubMed

    Homer, R Webster; Swanson, Jon; Jilek, Robert J; Hurst, Tad; Clark, Robert D

    2008-12-01

    SYBYL line notation (SLN) is a powerful way to represent molecular structures, reactions, libraries of structures, molecular fragments, formulations, molecular queries, and reaction queries. Nearly any chemical structure imaginable, including macromolecules, pharmaceuticals, catalysts, and even combinatorial libraries can be represented as an SLN string. The language provides a rich syntax for database queries comparable to SMARTS. It provides full Markush, R-Group, reaction, and macro atom capabilities in a single unified notation. It includes the ability to specify 3D conformations and 2D depictions. All the information necessary to recreate the structure in a modeling or drawing package is present in a single, concise string of ASCII characters. This makes SLN ideal for structure communication over global computer networks between applications sitting at remote sites. Unlike SMILES and its derivatives, SLN accomplishes this within a single unified syntax. Structures, queries, compounds, reactions, and virtual libraries can all be represented in a single notation.

  4. Redesign of Library Workflows: Experimental Models for Electronic Resource Description.

    ERIC Educational Resources Information Center

    Calhoun, Karen

    This paper explores the potential for and progress of a gradual transition from a highly centralized model for cataloging to an iterative, collaborative, and broadly distributed model for electronic resource description. The purpose is to alert library managers to some experiments underway and to help them conceptualize new methods for defining,…

  5. U.S. Depository Library Council Electronic Transition Report.

    ERIC Educational Resources Information Center

    Farrell, Maggie

    2000-01-01

    Examines the Government Printing Office's (GPO's) progress on its transition to a more electronic Federal Depository Library Program (FDLP). Encourages GPO to expand its services and training beyond the FDLP, and to review and consolidate online bibliographic tools to be more intuitive and functional. (Author/LRW)

  6. U.S. Depository Library Council Electronic Transition Report.

    ERIC Educational Resources Information Center

    Farrell, Maggie

    2000-01-01

    Examines the Government Printing Office's (GPO's) progress on its transition to a more electronic Federal Depository Library Program (FDLP). Encourages GPO to expand its services and training beyond the FDLP, and to review and consolidate online bibliographic tools to be more intuitive and functional. (Author/LRW)

  7. Electronic Publishing, Libraries, and the Survival of Information.

    ERIC Educational Resources Information Center

    Neavill, Gordon B.

    1984-01-01

    Explores some of the problems that will confront librarians and scholars in a paperless society. Highlights include the technological determinants of information survival, the library's institutional role, the stock of knowledge, electronic publishing and the stock of knowledge, and other issues. Seven references are cited. (EJS)

  8. Copyright Policy and Practice in Electronic Reserves among ARL Libraries

    ERIC Educational Resources Information Center

    Hansen, David R.; Cross, William M.; Edwards, Phillip M.

    2013-01-01

    This paper presents the results of a survey of 110 ARL institutions regarding their copyright policies for providing electronic reserves. It compiles descriptive statistics on library practice as well as coding responses to reveal trends and shared practices. Finally, it presents conclusions about policy making, decision making and risk aversion…

  9. Libraries and the Creation of Electronic Texts for the Humanities.

    ERIC Educational Resources Information Center

    Smith, Natalia; Tibbo, Helen R.

    1996-01-01

    A survey of academic libraries and librarians with active text digitalization projects produced a framework of issues faced by librarians implementing electronic text projects. Discusses and ranks factors in text selection; data conversion; data presentation, including mark-up schemes and level of encoding; access; archiving; user and staff…

  10. Library Planning in the Electronic Era: Are the Stacks Necessary?

    ERIC Educational Resources Information Center

    Finnerty, Chuck

    2002-01-01

    Discussion of space planning for special libraries focuses on questioning the need for stacks for printed materials with the proliferation of electronic resources. Topics include considering all information resources formats; costs of space; and space-needs assessment, including a collection survey, staff, and function areas. (LRW)

  11. The Costs of Information Technology and the Electronic Library.

    ERIC Educational Resources Information Center

    Tebbetts, Diane R.

    2000-01-01

    Discusses the impact of information technology requirements on the costs of electronic libraries. Addresses key questions concerning hardware, software and network installation and upgrades and provides strategies for dealing with the needs for continuous funding and long-term financing that are essential for keeping up with the requirements of…

  12. Copyright Policy and Practice in Electronic Reserves among ARL Libraries

    ERIC Educational Resources Information Center

    Hansen, David R.; Cross, William M.; Edwards, Phillip M.

    2013-01-01

    This paper presents the results of a survey of 110 ARL institutions regarding their copyright policies for providing electronic reserves. It compiles descriptive statistics on library practice as well as coding responses to reveal trends and shared practices. Finally, it presents conclusions about policy making, decision making and risk aversion…

  13. Electronic Data Interchange (EDI) for Libraries and Publishers.

    ERIC Educational Resources Information Center

    Santosuosso, Joe

    1992-01-01

    Defines electronic data interchange (EDI) as the exchange of data between computer systems without human intervention or interpretation. Standards are discussed; and the implementation of EDI in libraries and the serials publishing community in the areas of orders and acquisitions, claims, and invoice processing is described. (LRW)

  14. The Electronic Revolution in Libraries: Microfilm Deja Vu?

    ERIC Educational Resources Information Center

    Cady, Susan A.

    1990-01-01

    Reviews the use of microfilm as an acquisitions and preservation tool in academic libraries, and discusses how this use has fallen short of predictions that microfilm would revolutionize research methodology and scholarly productivity. This history is used to provide cautionary guidance in approaching the era of electronic documentation. (35…

  15. Transforming Libraries: Issues and Innovations in Electronic Scholarly Publishing. Transforming Libraries Series. SPEC Kit 223.

    ERIC Educational Resources Information Center

    Soete, George J.

    This issue covers the broad topic of electronic scholarly publication. Some 25 professionals in 20 libraries, consortia, and publishing enterprises were interviewed for this issue. A section on issues and trends for managers discusses the proliferation of roles and models; assembling the critical mass; licensing, copyright and interlibrary loan;…

  16. The Geography of Virtual Questioning

    ERIC Educational Resources Information Center

    Mon, Lorri; Bishop, Bradley Wade; McClure, Charles R.; McGilvray, Jessica; Most, Linda; Milas, Theodore Patrick; Snead, John T.

    2009-01-01

    This article explores the geography of virtual questioning by using geographic information systems to study activity within the Florida Electronic Library "Ask a Librarian" collaborative chat service. Researchers mapped participating libraries throughout the state of Florida that served as virtual "entry portals" for users as…

  17. The Geography of Virtual Questioning

    ERIC Educational Resources Information Center

    Mon, Lorri; Bishop, Bradley Wade; McClure, Charles R.; McGilvray, Jessica; Most, Linda; Milas, Theodore Patrick; Snead, John T.

    2009-01-01

    This article explores the geography of virtual questioning by using geographic information systems to study activity within the Florida Electronic Library "Ask a Librarian" collaborative chat service. Researchers mapped participating libraries throughout the state of Florida that served as virtual "entry portals" for users as…

  18. Virtual Dreams Give Way to Digital Reality.

    ERIC Educational Resources Information Center

    LaGuardia, Cheryl

    1995-01-01

    Examines the shift from the vision of the virtual library to the digital library concept. Discusses attitudes toward electronic resources, CD-ROM technology, the appropriate use of electronic formats, differences in information needs, balance between print and electronic media in libraries, and collaborative resource development. A sidebar…

  19. Creating books for the National electronic Library for Health: expected barriers and useful lessons.

    PubMed

    O'Brien, C

    2000-12-01

    The National electronic Library for Health (NeLH) is now taking shape, as the virtual branch libraries begin to accumulate 'books', among their resources. In the Primary Care branch (http://www.nelh-pc.nhs.uk), one of the first available books was the Statement of Fees and Allowances (otherwise known as the Red Book). While being held up as an example of what the NeLH can offer, this book and the story of its transformation from paper to Internet format is a powerful example of how much further the National Health Service (NHS) must go before it can claim to be fully exploiting the benefits of information technology (IT). This article refers to the author's experience in producing electronic books for primary care using WaX software, and an example of a process change from paper to screen that was managed within a university administrative office. The author suggests that to reap optimal benefits from IT, the NeLH and its collaborators must address the fundamental issues of people and the paper-based processes used by information providers. The NeLH must work with both NHS IT trainers and information providers in a three-way collaboration involving key people and processes, to achieve the efficient production of an updateable and user-friendly library of electronic books.

  20. Natural product-like virtual libraries: recursive atom-based enumeration.

    PubMed

    Yu, Melvin J

    2011-03-28

    A new molecular enumerator is described that allows chemically and architecturally diverse sets of natural product-like and drug-like structures to be generated from a core structure as simple as a single carbon atom or as complex as a polycyclic ring system. Integrated with a rudimentary machine-learning algorithm, the enumerator has the ability to assemble biased virtual libraries enriched in compounds predicted to meet target criteria. The ability to dynamically generate relatively small focused libraries in a recursive manner could reduce the computational time and infrastructure necessary to construct and manage extremely large static libraries. Depending on enumeration conditions, natural product-like structures can be produced with a wide range of heterocyclic and alicyclic ring assemblies. Because natural products represent a proven source of validated structures for identifying and designing new drug candidates, mimicking the structural and topological diversity found in nature with a dynamic set of virtual natural product-like compounds may facilitate the creation of new ideas for novel, biologically relevant lead structures in areas of uncharted chemical space.

  1. The CMEE Library for Numerical Modeling of Electron Effects

    NASA Astrophysics Data System (ADS)

    Stoltz, Peter; Cohen, Ron; Molvik, Art; Furman, Miguel; Vay, Jean-Luc; Adelmann, Andreas

    2003-10-01

    The CMEE (Computational Modules for Electron Effects) library is a collection of computer routines for numerical modeling of electron effects in accelerator and plasma physics codes. The goal of this library is to make these numerical models available to any code in need of electron effects modeling, including high-power microwave codes, fusion wall interaction codes, laser-plasma codes, proton accelerator codes, and HIF codes. CMEE includes routines to model secondary electrons, neutral gas desorption and ionization. The secondary electron routines are based on routines from the POSINST code. The neutral gas desorption routines are based on a thermal binding model similar to the model in ,e.g., the LSP code. The ionization routines are based on the IONPACK library from Tech-X. This poster discusses the latest state of these routines, specifically implementation in the WARP code and comparisons to data from the High Current Experiment (HCX). In particular, recent comparisons between the CMEE routines and neutral gas desorption measurements from HCX are presented.

  2. Evaluation of a focused virtual library of heterobifunctional ligands for Clostridium difficile toxins.

    PubMed

    Sanhueza, Carlos A; Cartmell, Jonathan; El-Hawiet, Amr; Szpacenko, Adam; Kitova, Elena N; Daneshfar, Rambod; Klassen, John S; Lang, Dean E; Eugenio, Luiz; Ng, Kenneth K-S; Kitov, Pavel I; Bundle, David R

    2015-01-07

    A focused library of virtual heterobifunctional ligands was generated in silico and a set of ligands with recombined fragments was synthesized and evaluated for binding to Clostridium difficile toxins. The position of the trisaccharide fragment was used as a reference for filtering docked poses during virtual screening to match the trisaccharide ligand in a crystal structure. The peptoid, a diversity fragment probing the protein surface area adjacent to a known binding site, was generated by a multi-component Ugi reaction. Our approach combines modular fragment-based design with in silico screening of synthetically feasible compounds and lays the groundwork for future efforts in development of composite bifunctional ligands for large clostridial toxins.

  3. A virtual screening method for prediction of the HERG potassium channel liability of compound libraries.

    PubMed

    Roche, Olivier; Trube, Gerhard; Zuegge, Jochen; Pflimlin, Pascal; Alanine, Alexander; Schneider, Gisbert

    2002-05-03

    A computer-based method has been developed for prediction of the hERG (human ether-à-go-go related gene) K(+)-channel affinity of low molecular weight compounds. hERG channel blockage is a major concern in drug design, as such blocking agents can cause sudden cardiac death. Various techniques were applied to finding appropriate molecular descriptors for modeling structure-activity relationships: substructure analysis, self-organizing maps (SOM), principal component analysis (PCA), partial least squares fitting (PLS), and supervised neural networks. The most accurate prediction system was based on an artificial neural network. In a validation study, 93 % of the nonblocking agents and 71 % of the hERG channel blockers were correctly classified. This virtual screening method can be used for general compound-library shaping and combinatorial library design.

  4. Higher harmonics generation in relativistic electron beam with virtual cathode

    SciTech Connect

    Kurkin, S. A. Badarin, A. A.; Koronovskii, A. A.; Hramov, A. E.

    2014-09-15

    The study of the microwave generation regimes with intense higher harmonics taking place in a high-power vircator consisting of a relativistic electron beam with a virtual cathode has been made. The characteristics of these regimes, in particular, the typical spectra and their variations with the change of the system parameters (beam current, the induction of external magnetic field) as well as physical processes occurring in the system have been analyzed by means of 3D electromagnetic simulation. It has been shown that the system under study demonstrates the tendency to the sufficient growth of the amplitudes of higher harmonics in the spectrum of current oscillations in the VC region with the increase of beam current. The obtained results allow us to consider virtual cathode oscillators as promising high power mmw-to-THz sources.

  5. An Electron/Photon/Relaxation Data Library for MCNP6

    SciTech Connect

    Hughes, III, H. Grady

    2015-08-07

    The capabilities of the MCNP6 Monte Carlo code in simulation of electron transport, photon transport, and atomic relaxation have recently been significantly expanded. The enhancements include not only the extension of existing data and methods to lower energies, but also the introduction of new categories of data and methods. Support of these new capabilities has required major additions to and redesign of the associated data tables. In this paper we present the first complete documentation of the contents and format of the new electron-photon-relaxation data library now available with the initial production release of MCNP6.

  6. Virtual in-service training from the librarians' point of view in libraries of medical sciences universities in Tehran

    PubMed Central

    Mohaghegh, Niloofar; Raiesi Dehkordi, Puran; Alibeik, MohammadReza; Ghashghaee, Ahmad; Janbozorgi, Mojgan

    2016-01-01

    Background: In-service training courses are one of the most available programs that are used to improve the quantity and quality level of the staff services in various organizations, including libraries and information centers. With the advent of new technologies in the field of education, the problems and shortcomings of traditional in-service training courses were replaced with virtual ones. This study aimed to evaluate the virtual in-service training courses from the librarians' point of view in libraries of state universities of medical sciences in Tehran. Methods: This was a descriptive- analytical study. The statistical population consisted of all librarians at libraries of universities of medical sciences in Tehran. Out of 103 librarians working in the libraries under the study, 93 (90%) participated in this study. Data were collected, using a questionnaire. Results: The results revealed that 94/6% of librarians were satisfied to participate in virtual in-service training courses. In this study, only 45 out of 93 participants said that the virtual in-service courses were held in their libraries. Of the participants, 75.6% were satisfied with the length of training courses, and one month seemed to be adequate time duration for the librarians to be more satisfied. The satisfaction level of the individuals who participated in in-service courses of the National Library was moderate to high. A total of 84.4% participants announced that the productivity level of the training courses was moderate to high. The most important problem with which the librarians were confronted in virtual in-service training was the "low speed of the internet and inadequate computer substructures". Conclusion: Effectiveness of in-service training courses from librarians’ point of view was at an optimal level in the studied libraries. PMID:28491833

  7. Virtual in-service training from the librarians' point of view in libraries of medical sciences universities in Tehran.

    PubMed

    Mohaghegh, Niloofar; Raiesi Dehkordi, Puran; Alibeik, MohammadReza; Ghashghaee, Ahmad; Janbozorgi, Mojgan

    2016-01-01

    Background: In-service training courses are one of the most available programs that are used to improve the quantity and quality level of the staff services in various organizations, including libraries and information centers. With the advent of new technologies in the field of education, the problems and shortcomings of traditional in-service training courses were replaced with virtual ones. This study aimed to evaluate the virtual in-service training courses from the librarians' point of view in libraries of state universities of medical sciences in Tehran. Methods: This was a descriptive- analytical study. The statistical population consisted of all librarians at libraries of universities of medical sciences in Tehran. Out of 103 librarians working in the libraries under the study, 93 (90%) participated in this study. Data were collected, using a questionnaire. Results: The results revealed that 94/6% of librarians were satisfied to participate in virtual in-service training courses. In this study, only 45 out of 93 participants said that the virtual in-service courses were held in their libraries. Of the participants, 75.6% were satisfied with the length of training courses, and one month seemed to be adequate time duration for the librarians to be more satisfied. The satisfaction level of the individuals who participated in in-service courses of the National Library was moderate to high. A total of 84.4% participants announced that the productivity level of the training courses was moderate to high. The most important problem with which the librarians were confronted in virtual in-service training was the "low speed of the internet and inadequate computer substructures". Conclusion: Effectiveness of in-service training courses from librarians' point of view was at an optimal level in the studied libraries.

  8. Research on distributed virtual reality system in electronic commerce

    NASA Astrophysics Data System (ADS)

    Xue, Qiang; Wang, Jiening; Sun, Jizhou

    2004-03-01

    In this paper, Distributed Virtual Reality (DVR) technology applied in Electronical Commerce (EC) is discussed. DVR has the capability of providing a new means for human being to recognize, analyze and resolve the large scale, complex problems, which makes it develop quickly in EC fields. The technology of CSCW (Computer Supported Cooperative Work) and middleware is introduced into the development of EC-DVR system to meet the need of a platform which can provide the necessary cooperation and communication services to avoid developing the basic module repeatedly. Finally, the paper gives a platform structure of EC-DVR system.

  9. Discovery of potent inhibitors of soluble epoxide hydrolase by combinatorial library design and structure-based virtual screening.

    PubMed

    Xing, Li; McDonald, Joseph J; Kolodziej, Steve A; Kurumbail, Ravi G; Williams, Jennifer M; Warren, Chad J; O'Neal, Janet M; Skepner, Jill E; Roberds, Steven L

    2011-03-10

    Structure-based virtual screening was applied to design combinatorial libraries to discover novel and potent soluble epoxide hydrolase (sEH) inhibitors. X-ray crystal structures revealed unique interactions for a benzoxazole template in addition to the conserved hydrogen bonds with the catalytic machinery of sEH. By exploitation of the favorable binding elements, two iterations of library design based on amide coupling were employed, guided principally by the docking results of the enumerated virtual products. Biological screening of the libraries demonstrated as high as 90% hit rate, of which over two dozen compounds were single digit nanomolar sEH inhibitors by IC(50) determination. In total the library design and synthesis produced more than 300 submicromolar sEH inhibitors. In cellular systems consistent activities were demonstrated with biochemical measurements. The SAR understanding of the benzoxazole template provides valuable insights into discovery of novel sEH inhibitors as therapeutic agents.

  10. CSBB-ConeExclusion, adapting structure based solution virtual screening to libraries on solid support.

    PubMed

    Shave, Steven; Auer, Manfred

    2013-12-23

    Combinatorial chemical libraries produced on solid support offer fast and cost-effective access to a large number of unique compounds. If such libraries are screened directly on-bead, the speed at which chemical space can be explored by chemists is much greater than that addressable using solution based synthesis and screening methods. Solution based screening has a large supporting body of software such as structure-based virtual screening tools which enable the prediction of protein-ligand complexes. Use of these techniques to predict the protein bound complexes of compounds synthesized on solid support neglects to take into account the conjugation site on the small molecule ligand. This may invalidate predicted binding modes, the linker may be clashing with protein atoms. We present CSBB-ConeExclusion, a methodology and computer program which provides a measure of the applicability of solution dockings to solid support. Output is given in the form of statistics for each docking pose, a unique 2D visualization method which can be used to determine applicability at a glance, and automatically generated PyMol scripts allowing visualization of protein atom incursion into a defined exclusion volume. CSBB-ConeExclusion is then exemplarically used to determine the optimum attachment point for a purine library targeting cyclin-dependent kinase 2 CDK2.

  11. Browsing the Virtual Stacks: Making Electronic Reference Tools More Visible to Users

    ERIC Educational Resources Information Center

    Peterson, Elizabeth

    2008-01-01

    Electronic reference resources are expanding traditional print reference collections far beyond the walls of the library building. While the library literature has seen a debate rage about the various merits and pitfalls of electronic reference sources, no one disputes they are here to stay. As more of the library content becomes available through…

  12. Browsing the Virtual Stacks: Making Electronic Reference Tools More Visible to Users

    ERIC Educational Resources Information Center

    Peterson, Elizabeth

    2008-01-01

    Electronic reference resources are expanding traditional print reference collections far beyond the walls of the library building. While the library literature has seen a debate rage about the various merits and pitfalls of electronic reference sources, no one disputes they are here to stay. As more of the library content becomes available through…

  13. Bringing Up Gopher: Access to Local & Remote Electronic Resources for University Library Users.

    ERIC Educational Resources Information Center

    Brown, Melvin Marlo; And Others

    Some of the administrative and organizational issues in creating a gopher, specifically a library gopher for university libraries, are discussed. In 1993 the Electronic Collections Task Force of the New Mexico State University library administration began to develop a library-based gopher system that would enable users to have unlimited access to…

  14. Pharmacophore identification, in silico screening, and virtual library design for inhibitors of the human factor Xa.

    PubMed

    Krovat, Eva M; Frühwirth, Karin H; Langer, Thierry

    2005-01-01

    Factor Xa inhibitors are innovative anticoagulant agents that provide a better safety/efficacy profile compared to other anticoagulative drugs. A chemical feature-based modeling approach was applied to identify crucial pharmacophore patterns from 3D crystal structures of inhibitors bound to human factor Xa (Pdb entries 1fjs, 1kns, 1eqz) using the software LIGANDSCOUT and CATALYST. The complex structures were selected regarding the criteria of high inhibitory potency (i.e. all ligands show K(i) values against factor Xa in the subnanomolar range) and good resolution (i.e. at least 2.2 A) in order to generate selective and high quality pharmacophore models. The resulting chemical-feature based hypotheses were used for virtual screening of commercial molecular databases such as the WDI database. Furthermore, a ligand-based molecular modeling approach was performed to obtain common-feature hypotheses that represent the relevant chemical interactions between 10 bioactive factor Xa inhibitors and the protein, respectively. In a next step a virtual combinatorial library was designed in order to generate new compounds with similar chemical and spatial properties as known inhibitors. The software tool ILIB DIVERSE was used for this procedure in order to provide new scaffolds of this group of anticoagulants. Finally we present the combination of these two techniques, hence virtual screening was performed with selective pharmacophore models in a focused virtual combinatorial database. De novo derived molecular scaffolds that were able to adequately satisfy the pharmacophore criteria are revealed and are promising templates for candidates for further development.

  15. If You Can Make It There, You Can Make It Anywhere: Providing Reference and Instructional Library Services in the Virtual Environment

    ERIC Educational Resources Information Center

    Leonard, Elizabeth; Morasch, Maureen J.

    2012-01-01

    Despite the old-fashioned view of the academic library as a static institution, libraries can and do change in response to the needs of users and stakeholders. Perhaps the most dramatic shift in services has been the transition from a purely physical to a combination physical/virtual or even virtual-only environment. This article examines how…

  16. Digital Division Is Cultural Exclusion, but Is Digital Inclusion Cultural Inclusion?; We Come from Around the World and Share Similar Visions; Oksale: An Indigenous Approach to Creating a Virtual Library of Education Resources; Whose Rules? Intellectual Property, Culture and Indigenous Communities.

    ERIC Educational Resources Information Center

    Worcman, Karen; Holland, Maurita Peterson; Roy, Loriene; Larsen, Peter; Seadle, Michael

    2002-01-01

    Includes four articles that discuss digital technology and indigenous communities. Highlights include digitization of cultural resources; cultural instantiation in electronic media; partnerships; the needs of indigenous groups; library school students' service-based learning experiences in creating a virtual library for a tribal village; and…

  17. Digital Division Is Cultural Exclusion, but Is Digital Inclusion Cultural Inclusion?; We Come from Around the World and Share Similar Visions; Oksale: An Indigenous Approach to Creating a Virtual Library of Education Resources; Whose Rules? Intellectual Property, Culture and Indigenous Communities.

    ERIC Educational Resources Information Center

    Worcman, Karen; Holland, Maurita Peterson; Roy, Loriene; Larsen, Peter; Seadle, Michael

    2002-01-01

    Includes four articles that discuss digital technology and indigenous communities. Highlights include digitization of cultural resources; cultural instantiation in electronic media; partnerships; the needs of indigenous groups; library school students' service-based learning experiences in creating a virtual library for a tribal village; and…

  18. The Use of Electronic Mail in Research Libraries. SPEC Kit #149.

    ERIC Educational Resources Information Center

    Wiltse, Helen

    Noting that the primary function of electronic mail within research libraries has changed from interlibrary loan to administrative purposes in the last four years, this kit begins with an overview of the results of Association of Research Libraries (ARL) surveys of the use of electronic mail (e-mail) in member libraries conducted in 1984 and 1988.…

  19. The Use of Electronic Mail in Research Libraries. SPEC Kit #149.

    ERIC Educational Resources Information Center

    Wiltse, Helen

    Noting that the primary function of electronic mail within research libraries has changed from interlibrary loan to administrative purposes in the last four years, this kit begins with an overview of the results of Association of Research Libraries (ARL) surveys of the use of electronic mail (e-mail) in member libraries conducted in 1984 and 1988.…

  20. Electronic Journals in ARL Libraries: Policies and Procedures. SPEC Kit 201 and Flyer 201.

    ERIC Educational Resources Information Center

    Parang, Elizabeth, Comp.; Saunders, Laverna, Comp.

    Scholarly journal publishing is undergoing a transformation from paper to electronic distribution. Members of the Association of Research Libraries (ARL) have become pioneers in providing access to electronic journals. Because the policies and procedures that these libraries have developed can be guides for other libraries, a survey was sent to…

  1. A graph-based approach to construct target-focused libraries for virtual screening.

    PubMed

    Naderi, Misagh; Alvin, Chris; Ding, Yun; Mukhopadhyay, Supratik; Brylinski, Michal

    2016-01-01

    Due to exorbitant costs of high-throughput screening, many drug discovery projects commonly employ inexpensive virtual screening to support experimental efforts. However, the vast majority of compounds in widely used screening libraries, such as the ZINC database, will have a very low probability to exhibit the desired bioactivity for a given protein. Although combinatorial chemistry methods can be used to augment existing compound libraries with novel drug-like compounds, the broad chemical space is often too large to be explored. Consequently, the trend in library design has shifted to produce screening collections specifically tailored to modulate the function of a particular target or a protein family. Assuming that organic compounds are composed of sets of rigid fragments connected by flexible linkers, a molecule can be decomposed into its building blocks tracking their atomic connectivity. On this account, we developed eSynth, an exhaustive graph-based search algorithm to computationally synthesize new compounds by reconnecting these building blocks following their connectivity patterns. We conducted a series of benchmarking calculations against the Directory of Useful Decoys, Enhanced database. First, in a self-benchmarking test, the correctness of the algorithm is validated with the objective to recover a molecule from its building blocks. Encouragingly, eSynth can efficiently rebuild more than 80 % of active molecules from their fragment components. Next, the capability to discover novel scaffolds is assessed in a cross-benchmarking test, where eSynth successfully reconstructed 40 % of the target molecules using fragments extracted from chemically distinct compounds. Despite an enormous chemical space to be explored, eSynth is computationally efficient; half of the molecules are rebuilt in less than a second, whereas 90 % take only about a minute to be generated. eSynth can successfully reconstruct chemically feasible molecules from molecular fragments

  2. Astronomical Books in Virtual Library of Faculty of Mathematics in Belgrade

    NASA Astrophysics Data System (ADS)

    Pejovic, N.; Mijajlovic, Z.

    2012-12-01

    The Virtual Library of the Faculty of Mathematics in Belgrade, at the address http://elibrary.matf.bg.ac.rs, contains about 100 digitized books related to astronomy. These books are written mostly by Serbian scientists but there are also translations into Serbian by foreign authors. This article presents a list of books written by the following authors: Rudjer Bo\\vsković, Zaharije Orfelin, Atanasije Stojković, Djordje Stanojević, Milan Andonović, Kosta Stojanović, Nikolai Tsinger, Milutin Milanković, Milan Nedeljković, Pavle Vujević, Vojislav Minković, Zaharije Brkić, Branislav Ševarlić, Jovan Simovljević and Sergei Blažko. Some of these books had the great influence on the development of astronomy, geodesy and mathematical geography in Serbia. The full list of these books is given and a selection of them is presented and commented.

  3. Digitized Works of B. Sevarlic in Virtual Library of Faculty of Mathematics

    NASA Astrophysics Data System (ADS)

    Pejovic, N.; Dacic, M.

    2012-12-01

    In the Virtual Library of the Faculty of Mathematics http://elibrary.matf.bg.ac.rs, there are eleven digitized works of Branislav Ševarlić, professor of the Belgrade University. These works include his doctoral dissertation, four university text-books on astronomy, three translations of books written by Russian authors, two textbooks for secondary schools, and the last one is the Astronomical Atlas. A particularly important work is his book General Astronomy (1971) as it was used for generations for teaching of astronomy at the University of Belgrade. The aim of this paper is to present all these works as well as the short biography of Professor Branislav Ševarlić.

  4. Virtual screening discovery of new acetylcholinesterase inhibitors issued from CERMN chemical library.

    PubMed

    Sopkova-de Oliveira Santos, Jana; Lesnard, Aurelien; Agondanou, Jean-Hugues; Dupont, Nathalie; Godard, Anne-Marie; Stiebing, Silvia; Rochais, Christophe; Fabis, Frederic; Dallemagne, Patrick; Bureau, Ronan; Rault, Sylvain

    2010-03-22

    In our quest to find new inhibitors able to inhibit acetylcholinesterase (AChE) and, at the same time, to protect neurons from beta amyloid toxicity, i.e., inhibitors interacting with the catalytic anionic subsite as well as with the peripherical anionic site of AChE, a virtual screening of the Centre d'Etudes et de Recherche sur le Medicament de Normandie (CERMN) chemical library was carried out. Two complementary approaches were applied, i.e., a ligand- and a structure-based screening. Each screening led to the selection of different compounds, but only two were present in both screening results. In vitro tests on AChE showed that one of those compounds presented a very good inhibition activity, of the same order as Donepezil. This result shows the real complementary of both methods for the discovery of new ligands.

  5. Virtual screening of protein kinase C inhibitors from natural product library to modulate general anaesthetic effects.

    PubMed

    Zhao, Junhui; Zhou, Chuixian

    2015-01-01

    Protein kinase C (PKC) plays a key role in neurotransmission in the central nervous system, and targeting PKC domain is considered as a strategy to modulate the anaesthetic effects. In this study, we described a synthetic pipeline to perform high-throughput virtual screening against a large library of 3D structural natural products released recently in order to discover those potential PKC modulators. A total of 100 natural products with top scores were raised, from which 12 promising candidates were tested to determine their inhibitory potencies against PKC. As might be expected, the promiscuous kinase inhibitor staurosporine showed a high PKC inhibitory activity (IC50 = 64 nM), and other two tested compounds, i.e. fisetin and tetrahydropapaverine, were also highly potent with their activities at nanomolar level (IC50 = 370 and 190, respectively).

  6. Generating "fragment-based virtual library" using pocket similarity search of ligand-receptor complexes.

    PubMed

    Khashan, Raed S

    2015-01-01

    As the number of available ligand-receptor complexes is increasing, researchers are becoming more dedicated to mine these complexes to aid in the drug design and development process. We present free software which is developed as a tool for performing similarity search across ligand-receptor complexes for identifying binding pockets which are similar to that of a target receptor. The search is based on 3D-geometric and chemical similarity of the atoms forming the binding pocket. For each match identified, the ligand's fragment(s) corresponding to that binding pocket are extracted, thus forming a virtual library of fragments (FragVLib) that is useful for structure-based drug design. The program provides a very useful tool to explore available databases.

  7. Discovery of novel SERCA inhibitors by virtual screening of a large compound library.

    PubMed

    Elam, Christopher; Lape, Michael; Deye, Joel; Zultowsky, Jodie; Stanton, David T; Paula, Stefan

    2011-05-01

    Two screening protocols based on recursive partitioning and computational ligand docking methodologies, respectively, were employed for virtual screens of a compound library with 345,000 entries for novel inhibitors of the enzyme sarco/endoplasmic reticulum calcium ATPase (SERCA), a potential target for cancer chemotherapy. A total of 72 compounds that were predicted to be potential inhibitors of SERCA were tested in bioassays and 17 displayed inhibitory potencies at concentrations below 100 μM. The majority of these inhibitors were composed of two phenyl rings tethered to each other by a short link of one to three atoms. Putative interactions between SERCA and the inhibitors were identified by inspection of docking-predicted poses and some of the structural features required for effective SERCA inhibition were determined by analysis of the classification pattern employed by the recursive partitioning models.

  8. Understanding Dermatan Sulfate-Heparin Cofactor II Interaction through Virtual Library Screening.

    PubMed

    Raghuraman, Arjun; Mosier, Philip D; Desai, Umesh R

    2010-09-09

    Dermatan sulfate, an important member of the glycosaminoglycan family, interacts with heparin cofactor II, a member of the serpin family of proteins, to modulate antithrombotic response. Yet, the nature of this interaction remains poorly understood at a molecular level. We report the genetic algorithm-based combinatorial virtual library screening study of a natural, high-affinity dermatan sulfate hexasaccharide with heparin cofactor II. Of the 192 topologies possible for the hexasaccharide, only 16 satisfied the "high-specificity" criteria used in computational study. Of these, 13 topologies were predicted to bind in the heparin-binding site of heparin cofactor II at a ∼60° angle to helix D, a novel binding mode. This new binding geometry satisfies all known solution and mutagenesis data and supports thrombin ternary complexation through a template mechanism. The study is expected to facilitate the design of allosteric agonists of heparin cofactor II as antithrombotic agents.

  9. High-resolution AMLCD for the electronic library system

    NASA Astrophysics Data System (ADS)

    Martin, Russel A.; Middo, Kathy; Turner, William D.; Lewis, Alan; Thompson, Malcolm J.; Silverstein, Louis D.

    1994-06-01

    The Electronic Library System (ELS), is a proposed data resource for the cockpit which can provide the aircrew with a vast array of technical information on their aircraft and flight plan. This information includes, but is not limited to, approach plates, Jeppeson Charts, and aircraft technical manuals. Most of these data are appropriate for digitization at high resolution (300 spi). Xerox Corporation has developed a flat panel active matrix liquid crystal display, AMLCD, that is an excellent match to the ELS, due to its innovative and aggressive design.

  10. Social Question and Answer Services versus Library Virtual Reference: Evaluation and Comparison from the Users' Perspective

    ERIC Educational Resources Information Center

    Zhang, Yin; Deng, Shengli

    2014-01-01

    Introduction: In recent years, the introduction of social question and answer services and other Internet tools have expanded the ways in which people have their questions answered. There has been speculation and debate over whether such services and other Internet tools are replacing library virtual reference services. Method: Most previous…

  11. A Case Study of the Usability Testing of the University of South Florida's Virtual Library Interface Design.

    ERIC Educational Resources Information Center

    Allen, Maryellen

    2002-01-01

    Discussion of usability testing of Web interfaces for virtual libraries focuses on a usability study conducted at the University of South Florida. Highlights include testing instruments; discrepancies between actual performance and perceived performance; and the need to use plainer language and less jargon. (LRW)

  12. Virtual Libraries in the Southeast: A Guide to Online Resources Available to Educators in the SERVE States. Special Report.

    ERIC Educational Resources Information Center

    Hartness, Elizabeth Williams; Bingham, Margaret H.

    In the past 5 years, each state in the Southeastern Regional Vision for Education (SERVE) region (Alabama, Florida, Georgia, Mississippi, North Carolina, and South Carolina) developed virtual libraries that provide citizens access to licensed databases. This guide describes each state's offerings including the methods of access, resources, and…

  13. A Case Study of the Usability Testing of the University of South Florida's Virtual Library Interface Design.

    ERIC Educational Resources Information Center

    Allen, Maryellen

    2002-01-01

    Discussion of usability testing of Web interfaces for virtual libraries focuses on a usability study conducted at the University of South Florida. Highlights include testing instruments; discrepancies between actual performance and perceived performance; and the need to use plainer language and less jargon. (LRW)

  14. Issues in the Development of an All-Digital Public Health Library in Michigan: The Michigan Community Health Electronic Library

    ERIC Educational Resources Information Center

    Brenneise, Harvey R.

    2005-01-01

    The Michigan Community Health Electronic Library (MCHEL) serves the public health and other community health workers in Michigan. It is committed to desktop delivery of the best health information to its primary clientele, with as much as possible in digital full-text form. It collaborates with other libraries in the state to make this possible.…

  15. The Third Library Revolution: Experiments with Electronic Community Libraries in Denmark.

    ERIC Educational Resources Information Center

    Larsen, Gitte; Qvortrup, Lars

    1988-01-01

    Describes the HELOS project in Denmark, which is using information technology to facilitate library development, increase levels of library and information services, and increase levels of technological qualifications of library staff among four rural libraries. The discussion highlights library and information services offered, hardware and…

  16. A rational workflow for sequential virtual screening of chemical libraries on searching for new tyrosinase inhibitors.

    PubMed

    Le-Thi-Thu, Huong; Casanola-Martín, Gerardo M; Marrero-Ponce, Yovani; Rescigno, Antonio; Abad, Concepcion; Khan, Mahmud Tareq Hassan

    2014-01-01

    The tyrosinase is a bifunctional, copper-containing enzyme widely distributed in the phylogenetic tree. This enzyme is involved in the production of melanin and some other pigments in humans, animals and plants, including skin pigmentations in mammals, and browning process in plants and vegetables. Therefore, enzyme inhibitors has been under the attention of the scientist community, due to its broad applications in food, cosmetic, agricultural and medicinal fields, to avoid the undesirable effects of abnormal melanin overproduction. However, the research of novel chemical with antityrosinase activity demands the use of more efficient tools to speed up the tyrosinase inhibitors discovery process. This chapter is focused in the different components of a predictive modeling workflow for the identification and prioritization of potential new compounds with activity against the tyrosinase enzyme. In this case, two structure chemical libraries Spectrum Collection and Drugbank are used in this attempt to combine different virtual screening data mining techniques, in a sequential manner helping to avoid the usually expensive and time consuming traditional methods. Some of the sequential steps summarize here comprise the use of drug-likeness filters, similarity searching, classification and potency QSAR multiclassifier systems, modeling molecular interactions systems, and similarity/diversity analysis. Finally, the methodologies showed here provide a rational workflow for virtual screening hit analysis and selection as a promissory drug discovery strategy for use in target identification phase.

  17. Timelike Virtual Compton Scattering from Electron-Positron Radiative Annihilation

    SciTech Connect

    Afanasev, Andrei; Brodsky, Stanley J.; Carlson, Carl E.; Mukherjee, Asmita; /Indian Inst. Tech., Mumbai

    2009-03-31

    We propose measurements of the deeply virtual Compton amplitude (DVCS) {gamma}* {yields} H{bar H}{gamma} in the timelike t = (p{sub H} + p{sub {bar H}}){sup 2} > 0 kinematic domain which is accessible at electron-positron colliders via the radiative annihilation process e{sup +}e{sup -} {yields} H{bar H}{gamma}. These processes allow the measurement of timelike deeply virtual Compton scattering for a variety of H{bar H} hadron pairs such as {pi}{sup +}{pi}{sup -}, K{sup +}K{sup -}, and D{bar D} as well as p{bar p}. As in the conventional spacelike DVCS, there are interfering coherent amplitudes contributing to the timelike processes involving C = - form factors. The interference between the amplitudes measures the phase of the C = + timelike DVCS amplitude relative to the phase of the timelike form factors and can be isolated by considering the forward-backward e{sup +} {leftrightarrow} e{sup -} asymmetry. The J = 0 fixed pole contribution which arises from the local coupling of the two photons to the quark current plays a special role. As an example we present a simple model.

  18. Timelike Virtual Compton Scattering from Electron-Positron Radiative Annihilation

    SciTech Connect

    Andrei Afanaciev,Andrei Afanasev, Stanley J. Brodsky, Carl E. Carlson, Asmita Mukherjee

    2010-02-01

    We propose measurements of the deeply virtual Compton amplitude (DVCS), gamma* to H H-bar gamma, in the timelike t = (p_{H} + p_{H-bar})^2 > 0 kinematic domain which is accessible at electron-positron colliders via the radiative annihilation process e+ e- to H H-bar gamma. These processes allow the measurement of timelike deeply virtual Compton scattering for a variety of H H-bar hadron pairs such as pi+ pi-, K+ K-, and D D-bar as well as p p-bar. As in the conventional spacelike DVCS, there are interfering coherent amplitudes contributing to the timelike processes involving C= - form factors. The interference between the amplitudes measures the phase of the C=+ timelike DVCS amplitude relative to the phase of the timelike form factors and can be isolated by considering the forward-backward e+ \\leftrightarrow e- asymmetry. The J=0 fixed pole contribution which arises from the local coupling of the two photons to the quark current plays a special role. As an example we present a simple model.

  19. A review of electronic journal acquisition, management, and use in health sciences libraries

    PubMed Central

    Burrows, Suzetta

    2006-01-01

    Purpose: The paper describes patterns of electronic journal usage in health sciences libraries during the past decade. Method: The paper presents a case study, documenting the pattern of acquisition, management, and usage at the Louis Calder Memorial Library of the University of Miami Miller School of Medicine. Results: Health sciences journals were early to offer electronic alternatives to print. As a result, health sciences libraries, their patrons, and the public at large were early to embrace the new versions and continue to embrace the significant changes in scholarly communication they enable. Although the patterns of electronic journals among health sciences libraries and other special and academic libraries have similarities, they also have differences. Broad studies of electronic journals in non–health sciences libraries have been published, but a retrospective review of electronic journals in health sciences libraries has not. PMID:16404472

  20. A review of electronic journal acquisition, management, and use in health sciences libraries.

    PubMed

    Burrows, Suzetta

    2006-01-01

    The paper describes patterns of electronic journal usage in health sciences libraries during the past decade. The paper presents a case study, documenting the pattern of acquisition, management, and usage at the Louis Calder Memorial Library of the University of Miami Miller School of Medicine. Health sciences journals were early to offer electronic alternatives to print. As a result, health sciences libraries, their patrons, and the public at large were early to embrace the new versions and continue to embrace the significant changes in scholarly communication they enable. Although the patterns of electronic journals among health sciences libraries and other special and academic libraries have similarities, they also have differences. Broad studies of electronic journals in non-health sciences libraries have been published, but a retrospective review of electronic journals in health sciences libraries has not.

  1. Exploiting the colloidal nanocrystal library to construct electronic devices

    NASA Astrophysics Data System (ADS)

    Choi, Ji-Hyuk; Wang, Han; Oh, Soong Ju; Paik, Taejong; Sung, Pil; Sung, Jinwoo; Ye, Xingchen; Zhao, Tianshuo; Diroll, Benjamin T.; Murray, Christopher B.; Kagan, Cherie R.

    2016-04-01

    Synthetic methods produce libraries of colloidal nanocrystals with tunable physical properties by tailoring the nanocrystal size, shape, and composition. Here, we exploit colloidal nanocrystal diversity and design the materials, interfaces, and processes to construct all-nanocrystal electronic devices using solution-based processes. Metallic silver and semiconducting cadmium selenide nanocrystals are deposited to form high-conductivity and high-mobility thin-film electrodes and channel layers of field-effect transistors. Insulating aluminum oxide nanocrystals are assembled layer by layer with polyelectrolytes to form high-dielectric constant gate insulator layers for low-voltage device operation. Metallic indium nanocrystals are codispersed with silver nanocrystals to integrate an indium supply in the deposited electrodes that serves to passivate and dope the cadmium selenide nanocrystal channel layer. We fabricate all-nanocrystal field-effect transistors on flexible plastics with electron mobilities of 21.7 square centimeters per volt-second.

  2. Virtual libraries of tetrapyrrole macrocycles. Combinatorics, isomers, product distributions, and data mining.

    PubMed

    Taniguchi, Masahiko; Du, Hai; Lindsey, Jonathan S

    2011-09-26

    A software program (PorphyrinViLiGe) has been developed to enumerate the type and relative amounts of substituted tetrapyrrole macrocycles in a virtual library formed by one of four different classes of reactions. The classes include (1) 4-fold reaction of n disubstituted heterocycles (e.g., pyrroles or diiminoisoindolines) to form β-substituted porphyrins, β-substituted tetraazaporphyrins, or α- or β-substituted phthalocyanines; (2) combination of m aminoketones and n diones to form m × n pyrroles, which upon 4-fold reaction give β-substituted porphyrins; (3) derivatization of an 8-point tetrapyrrole scaffold with n reagents, and (4) 4-fold reaction of n aldehydes and pyrrole to form meso-substituted porphyrins. The program accommodates variable ratios of reactants, reversible or irreversible reaction (reaction classes 1 and 2), and degenerate modes of formation. Pólya's theorem (for enumeration of cyclic entities) has also been implemented and provides validation for reaction classes 3 and 4. The output includes the number and identity of distinct reaction-accessible substituent combinations, the number and identity of isomers thereof, and the theoretical mass spectrum. Provisions for data mining enable assessment of the number of products having a chosen pattern of substituents. Examples include derivatization of an octa-substituted phthalocyanine with eight reagents to afford a library of 2,099,728 members (yet only 6435 distinct substituent combinations) and reversible reaction of six distinct disubstituted pyrroles to afford 2649 members (yet only 126 distinct substituent combinations). In general, libraries of substituted tetrapyrrole macrocycles occupy a synthetically accessible region of chemical space that is rich in isomers (>99% or 95% for the two examples, respectively).

  3. Virtual screening of Abl inhibitors from large compound libraries by support vector machines.

    PubMed

    Liu, X H; Ma, X H; Tan, C Y; Jiang, Y Y; Go, M L; Low, B C; Chen, Y Z

    2009-09-01

    Abl promotes cancers by regulating cell morphogenesis, motility, growth, and survival. Successes of several marketed and clinical trial Abl inhibitors against leukemia and other cancers and appearances of reduced efficacies and drug resistances have led to significant interest in and efforts for developing new Abl inhibitors. In silico methods of pharmacophore, fragment, and molecular docking have been used in some of these efforts. It is desirable to explore other in silico methods capable of searching large compound libraries at high yields and reduced false-hit rates. We evaluated support vector machines (SVM) as a virtual screening tool for searching Abl inhibitors from large compound libraries. SVM trained and tested by 708 inhibitors and 65,494 putative noninhibitors correctly identified 84.4 to 92.3% inhibitors and 99.96 to 99.99% noninhibitors in 5-fold cross validation studies. SVM trained by 708 pre-2008 inhibitors and 65 494 putative noninhibitors correctly identified 50.5% of the 91 inhibitors reported since 2008 and predicted as inhibitors 29,072 (0.21%) of 13.56M PubChem, 659 (0.39%) of 168K MDDR, and 330 (5.0%) of 6638 MDDR compounds similar to the known inhibitors. SVM showed comparable yields and substantially reduced false-hit rates against two similarity based and another machine learning VS methods based on the same training and testing data sets and molecular descriptors. These suggest that SVM is capable of searching Abl inhibitors from large compound libraries at low false-hit rates.

  4. LEAP into the Pfizer Global Virtual Library (PGVL) space: creation of readily synthesizable design ideas automatically.

    PubMed

    Hu, Qiyue; Peng, Zhengwei; Kostrowicki, Jaroslav; Kuki, Atsuo

    2011-01-01

    Pfizer Global Virtual Library (PGVL) of 10(13) readily synthesizable molecules offers a tremendous opportunity for lead optimization and scaffold hopping in drug discovery projects. However, mining into a chemical space of this size presents a challenge for the concomitant design informatics due to the fact that standard molecular similarity searches against a collection of explicit molecules cannot be utilized, since no chemical information system could create and manage more than 10(8) explicit molecules. Nevertheless, by accepting a tolerable level of false negatives in search results, we were able to bypass the need for full 10(13) enumeration and enabled the efficient similarity search and retrieval into this huge chemical space for practical usage by medicinal chemists. In this report, two search methods (LEAP1 and LEAP2) are presented. The first method uses PGVL reaction knowledge to disassemble the incoming search query molecule into a set of reactants and then uses reactant-level similarities into actual available starting materials to focus on a much smaller sub-region of the full virtual library compound space. This sub-region is then explicitly enumerated and searched via a standard similarity method using the original query molecule. The second method uses a fuzzy mapping onto candidate reactions and does not require exact disassembly of the incoming query molecule. Instead Basis Products (or capped reactants) are mapped into the query molecule and the resultant asymmetric similarity scores are used to prioritize the corresponding reactions and reactant sets. All sets of Basis Products are inherently indexed to specific reactions and specific starting materials. This again allows focusing on a much smaller sub-region for explicit enumeration and subsequent standard product-level similarity search. A set of validation studies were conducted. The results have shown that the level of false negatives for the disassembly-based method is acceptable when the

  5. Electronic Bulletin Board System for the Federal Depository Library Program: A Study.

    ERIC Educational Resources Information Center

    MacGilvray, Marian W.; And Others.

    A study was conducted by an electronic bulletin board system (BBS) team to explore a variety of approaches to electronic communication between the Government Printing Office's (GPO) Library Programs Service and the depository libraries. After reviewing various dissemination technologies, the BBS team recommended that an electronic bulletin board…

  6. Virtual Lab to Develop Achievement in Electronic Circuits for Hearing-Impaired Students

    ERIC Educational Resources Information Center

    Baladoh, S. M.; Elgamal, A. F.; Abas, H. A.

    2017-01-01

    This paper aims to report and discuss the use of a virtual lab for developing achievement in electronic circuits for hearing-impaired students. Results from a number of studies have proved that the virtual lab allowed students to build and test a wide variety of electronic circuits. The present study was implemented to investigate the…

  7. Use and Users of Electronic Library Resources: An Overview and Analysis of Recent Research Studies

    ERIC Educational Resources Information Center

    Tenopir, Carol

    2003-01-01

    This Council on Library and Information Resources (CLIR) report summarizes and analyzes more than 200 recent research publications that focus on the use of electronic library resources (digital libraries and digital resources) and were published between 1995 and 2003. Eight major ongoing studies (each with multiple publications) are identified as…

  8. Access to Electronic Information, Services, and Networks: An Interpretation of the Library Bill of Rights.

    ERIC Educational Resources Information Center

    American Library Association, Chicago, IL. Office of Intellectual Freedom.

    The American Library Association (ALA) expresses the basic principles of librarianship in its "Code of Ethics" and in the "Library Bill of Rights" and its interpretations. All library system and network policies, procedures or regulations relating to electronic resources and services should be scrutinized for potential…

  9. A Study on Developing Evaluation Criteria for Electronic Resources in Evaluation Indicators of Libraries

    ERIC Educational Resources Information Center

    Noh, Younghee

    2010-01-01

    This study aimed to improve the current state of electronic resource evaluation in libraries. While the use of Web DB, e-book, e-journal, and other e-resources such as CD-ROM, DVD, and micro materials is increasing in libraries, their use is not comprehensively factored into the general evaluation of libraries and may diminish the reliability of…

  10. A Study on Developing Evaluation Criteria for Electronic Resources in Evaluation Indicators of Libraries

    ERIC Educational Resources Information Center

    Noh, Younghee

    2010-01-01

    This study aimed to improve the current state of electronic resource evaluation in libraries. While the use of Web DB, e-book, e-journal, and other e-resources such as CD-ROM, DVD, and micro materials is increasing in libraries, their use is not comprehensively factored into the general evaluation of libraries and may diminish the reliability of…

  11. Interactive stereo electron microscopy enhanced with virtual reality

    SciTech Connect

    Bethel, E.Wes; Bastacky, S.Jacob; Schwartz, Kenneth S.

    2001-12-17

    An analytical system is presented that is used to take measurements of objects perceived in stereo image pairs obtained from a scanning electron microscope (SEM). Our system operates by presenting a single stereo view that contains stereo image data obtained from the SEM, along with geometric representations of two types of virtual measurement instruments, a ''protractor'' and a ''caliper''. The measurements obtained from this system are an integral part of a medical study evaluating surfactant, a liquid coating the inner surface of the lung which makes possible the process of breathing. Measurements of the curvature and contact angle of submicron diameter droplets of a fluorocarbon deposited on the surface of airways are performed in order to determine surface tension of the air/liquid interface. This approach has been extended to a microscopic level from the techniques of traditional surface science by measuring submicrometer rather than millimeter diameter droplets, as well as the lengths and curvature of cilia responsible for movement of the surfactant, the airway's protective liquid blanket. An earlier implementation of this approach for taking angle measurements from objects perceived in stereo image pairs using a virtual protractor is extended in this paper to include distance measurements and to use a unified view model. The system is built around a unified view model that is derived from microscope-specific parameters, such as focal length, visible area and magnification. The unified view model ensures that the underlying view models and resultant binocular parallax cues are consistent between synthetic and acquired imagery. When the view models are consistent, it is possible to take measurements of features that are not constrained to lie within the projection plane. The system is first calibrated using non-clinical data of known size and resolution. Using the SEM, stereo image pairs of grids and spheres of known resolution are created to calibrate the

  12. New Trends in Electronic Publishing and Electronic Libraries. Publications of Essen University Library 6. Essen Symposium (Essen, West Germany, August 29-31, 1983).

    ERIC Educational Resources Information Center

    Helal, Ahmed H., Ed.; Weiss, Joachim W., Ed.

    This symposium examined issues in the planning, development, and implementation of library automation and the effects of electronic publishing. The following presentations are included in this collection: (1) "Will There Be Electronic Anarchy?" (Helen Henderson); (2) "Ergonomics in the Electronic Era" (Andrew Torok); (3)…

  13. New Trends in Electronic Publishing and Electronic Libraries. Publications of Essen University Library 6. Essen Symposium (Essen, West Germany, August 29-31, 1983).

    ERIC Educational Resources Information Center

    Helal, Ahmed H., Ed.; Weiss, Joachim W., Ed.

    This symposium examined issues in the planning, development, and implementation of library automation and the effects of electronic publishing. The following presentations are included in this collection: (1) "Will There Be Electronic Anarchy?" (Helen Henderson); (2) "Ergonomics in the Electronic Era" (Andrew Torok); (3)…

  14. Construction of a Virtual Scanning Electron Microscope (VSEM)

    NASA Technical Reports Server (NTRS)

    Fried, Glenn; Grosser, Benjamin

    2004-01-01

    The Imaging Technology Group (ITG) proposed to develop a Virtual SEM (VSEM) application and supporting materials as the first installed instrument in NASA s Virtual Laboratory Project. The instrument was to be a simulator modeled after an existing SEM, and was to mimic that real instrument as closely as possible. Virtual samples would be developed and provided along with the instrument, which would be written in Java.

  15. Construction of a Virtual Scanning Electron Microscope (VSEM)

    NASA Technical Reports Server (NTRS)

    Fried, Glenn; Grosser, Benjamin

    2004-01-01

    The Imaging Technology Group (ITG) proposed to develop a Virtual SEM (VSEM) application and supporting materials as the first installed instrument in NASA s Virtual Laboratory Project. The instrument was to be a simulator modeled after an existing SEM, and was to mimic that real instrument as closely as possible. Virtual samples would be developed and provided along with the instrument, which would be written in Java.

  16. Development of CXCR4 modulators by virtual HTS of a novel amide-sulfamide compound library.

    PubMed

    Bai, Renren; Shi, Qi; Liang, Zhongxing; Yoon, Younghyoun; Han, Yiran; Feng, Amber; Liu, Shuangping; Oum, Yoonhyeun; Yun, C Chris; Shim, Hyunsuk

    2017-01-27

    CXCR4 plays a crucial role in recruitment of inflammatory cells to inflammation sites at the beginning of the disease process. Modulating CXCR4 functions presents a new avenue for anti-inflammatory strategies. However, using CXCR4 antagonists for a long term usage presents potential serious side effect due to their stem cell mobilizing property. We have been developing partial CXCR4 antagonists without such property. A new computer-aided drug design program, the FRESH workflow, was used for anti-CXCR4 lead compound discovery and optimization, which coupled both compound library building and CXCR4 docking screens in one campaign. Based on the designed parent framework, 30 prioritized amide-sulfamide structures were obtained after systemic filtering and docking screening. Twelve compounds were prepared from the top-30 list. Most synthesized compounds exhibited good to excellent binding affinity to CXCR4. Compounds Ig and Im demonstrated notable in vivo suppressive activity against xylene-induced mouse ear inflammation (with 56% and 54% inhibition). Western blot analyses revealed that Ig significantly blocked CXCR4/CXCL12-mediated phosphorylation of Akt. Moreover, Ig attenuated the amount of TNF-α secreted by pathogenic E. coli-infected macrophages. More importantly, Ig had no observable cytotoxicity. Our results demonstrated that FRESH virtual high throughput screening program of targeted chemical class could successfully find potent lead compounds, and the amide-sulfamide pharmacophore was a novel and effective framework blocking CXCR4 function.

  17. The Role of the Library in an Electronic Society.

    ERIC Educational Resources Information Center

    Lancaster, F. Wilfrid, Ed.

    This compilation of papers presented at the sixteenth annual Clinic on Library Applications of Data Processing presents 13 papers on the library within the context of technological developments in publishing and related facets of human communication. Instead of focusing on library automation per se, the contributors have chosen to look at various…

  18. Personal, Electronic, Secure National Library of Medicine Hosts Health Records Conference

    MedlinePlus

    ... Bar Home Current Issue Past Issues EHR Personal, Electronic, Secure: National Library of Medicine Hosts Health Records ... One suggestion for saving money is to implement electronic personal health records. With this in mind, the ...

  19. eIFL (Electronic Information for Libraries): A Global Initiative of the Soros Foundations Network.

    ERIC Educational Resources Information Center

    Feret, Blazej; Kay, Michael

    This paper presents the history, current status, and future development of eIFL (Electronic Information for Libraries Direct)--a large-scale project run by the Soros Foundations Network and the Open Society Institute. The project aims to provide libraries in developing countries with access to a menu of electronic information resources. In 1999,…

  20. The Nonsubscription Side of Periodicals: Changes in Library Operations and Costs between Print and Electronic Formats

    ERIC Educational Resources Information Center

    Schonfeld, Roger C.; King, Donald W.; Okerson, Ann; Fenton, Eileen Gifford

    2004-01-01

    Many academic and research libraries are in the midst of what may ultimately be a major transition for various parts of their collection--a shift from print to electronic format. Libraries that had long subscribed only to print versions of journals are, in increasing numbers, licensing electronic versions to replace the print. What effects will…

  1. Library Groups, Decrying "Excessive Pricing," Demand New Policies on Electronic Journals.

    ERIC Educational Resources Information Center

    Guernsey, Lisa

    1998-01-01

    Electronic publishing creates challenges for traditional publishers and their library customers. Librarians call for an end to high prices for electronic publications and more flexibility in copying and distributing documents. Library consortia are forced to sign million-dollar deals for access to all of a publisher's on-line journals. Publishers…

  2. Construction of Chinese adult male phantom library and its application in the virtual calibration of in vivo measurement.

    PubMed

    Chen, Yizheng; Qiu, Rui; Li, Chunyan; Wu, Zhen; Li, Junli

    2016-03-07

    In vivo measurement is a main method of internal contamination evaluation, particularly for large numbers of people after a nuclear accident. Before the practical application, it is necessary to obtain the counting efficiency of the detector by calibration. The virtual calibration based on Monte Carlo simulation usually uses the reference human computational phantom, and the morphological difference between the monitored personnel with the calibrated phantom may lead to the deviation of the counting efficiency. Therefore, a phantom library containing a wide range of heights and total body masses is needed. In this study, a Chinese reference adult male polygon surface (CRAM_S) phantom was constructed based on the CRAM voxel phantom, with the organ models adjusted to match the Chinese reference data. CRAM_S phantom was then transformed to sitting posture for convenience in practical monitoring. Referring to the mass and height distribution of the Chinese adult male, a phantom library containing 84 phantoms was constructed by deforming the reference surface phantom. Phantoms in the library have 7 different heights ranging from 155 cm to 185 cm, and there are 12 phantoms with different total body masses in each height. As an example of application, organ specific and total counting efficiencies of Ba-133 were calculated using the MCNPX code, with two series of phantoms selected from the library. The influence of morphological variation on the counting efficiency was analyzed. The results show only using the reference phantom in virtual calibration may lead to an error of 68.9% for total counting efficiency. Thus the influence of morphological difference on virtual calibration can be greatly reduced using the phantom library with a wide range of masses and heights instead of a single reference phantom.

  3. Construction of Chinese adult male phantom library and its application in the virtual calibration of in vivo measurement

    NASA Astrophysics Data System (ADS)

    Chen, Yizheng; Qiu, Rui; Li, Chunyan; Wu, Zhen; Li, Junli

    2016-03-01

    In vivo measurement is a main method of internal contamination evaluation, particularly for large numbers of people after a nuclear accident. Before the practical application, it is necessary to obtain the counting efficiency of the detector by calibration. The virtual calibration based on Monte Carlo simulation usually uses the reference human computational phantom, and the morphological difference between the monitored personnel with the calibrated phantom may lead to the deviation of the counting efficiency. Therefore, a phantom library containing a wide range of heights and total body masses is needed. In this study, a Chinese reference adult male polygon surface (CRAM_S) phantom was constructed based on the CRAM voxel phantom, with the organ models adjusted to match the Chinese reference data. CRAMS phantom was then transformed to sitting posture for convenience in practical monitoring. Referring to the mass and height distribution of the Chinese adult male, a phantom library containing 84 phantoms was constructed by deforming the reference surface phantom. Phantoms in the library have 7 different heights ranging from 155 cm to 185 cm, and there are 12 phantoms with different total body masses in each height. As an example of application, organ specific and total counting efficiencies of Ba-133 were calculated using the MCNPX code, with two series of phantoms selected from the library. The influence of morphological variation on the counting efficiency was analyzed. The results show only using the reference phantom in virtual calibration may lead to an error of 68.9% for total counting efficiency. Thus the influence of morphological difference on virtual calibration can be greatly reduced using the phantom library with a wide range of masses and heights instead of a single reference phantom.

  4. The Legacy of the Baroque in Virtual Representations of Library Space

    ERIC Educational Resources Information Center

    Garrett, Jeffrey

    2004-01-01

    Library home pages and digital library sites have many properties and purposes in common with the Baroque wall-system libraries of seventeenth- and eighteenth-century Europe. Like their Baroque antecedents, contemporary library Web sites exploit the moment of entrance and the experience of the threshold to create and sustain the illusion of a…

  5. The Legacy of the Baroque in Virtual Representations of Library Space

    ERIC Educational Resources Information Center

    Garrett, Jeffrey

    2004-01-01

    Library home pages and digital library sites have many properties and purposes in common with the Baroque wall-system libraries of seventeenth- and eighteenth-century Europe. Like their Baroque antecedents, contemporary library Web sites exploit the moment of entrance and the experience of the threshold to create and sustain the illusion of a…

  6. NASA Electronic Library System (NELS): The system impact of security

    NASA Technical Reports Server (NTRS)

    Mcgregor, Terry L.

    1993-01-01

    This paper discusses security issues as they relate to the NASA Electronic Library System which is currently in use as the repository system for AdaNET System Version 3 (ASV3) being operated by MountainNET, Inc. NELS was originally designed to provide for public, development, and secure collections and objects. The secure feature for collections and objects was deferred in the initial system for implementation at a later date. The NELS system is now 9 months old and many lessons have been learned about the use and maintenance of library systems. MountainNET has 9 months of experience in operating the system and gathering feedback from the ASV3 user community. The user community has expressed an interest in seeing security features implemented in the current system. The time has come to take another look at the whole issue of security for the NELS system. Two requirements involving security have been put forth by MountainNET for the ASV3 system. The first is to incorporate at the collection level a security scheme to allow restricted access to collections. This should be invisible to end users and be controlled by librarians. The second is to allow inclusion of applications which can be executed only by a controlled group of users; for example, an application which can be executed by librarians only. The requirements provide a broad framework in which to work. These requirements raise more questions than answers. To explore the impact of these requirements a top down approach will be used.

  7. The National Library of Canada's Digital Library Initiatives.

    ERIC Educational Resources Information Center

    Hodges, Doug; Lunau, Carrol D.

    1999-01-01

    Incorporated in the National Library of Canada's (NLC) digital library initiatives are projects relating to digitization, collecting Canadian networked electronic publications, development of virtual catalogs, metadata creation, and preservation of digital resources. Issues relating to collaboration, access to digital collections and databases,…

  8. Electron density fingerprints (EDprints): virtual screening using assembled information of electron density.

    PubMed

    Kooistra, Albert J; Binsl, Thomas W; van Beek, Johannes H G M; de Graaf, Chris; Heringa, Jaap

    2010-10-25

    We have designed a method to encode properties related to the electron densities of molecules (calculated (1)H and (13)C NMR shifts and atomic partial charges) in molecular fingerprints (EDprints). EDprints was evaluated in terms of their retrospective virtual screening accuracy against the Directory of Useful Decoys (DUD) and compared to the established ligand-based similarity search methods MOLPRINT 2D and FCFP-4. Although there are no significant differences in the overall virtual screening accuracies of the three methods, specific examples highlight interesting differences between the new EDprints fingerprint method and the atom-centered circular fingerprint methods of MOLPRINT 2D and FCFP-4. On one hand, EDprints similarity searches can be biased by the molecular protonation state, especially when reference ligands contain multiple ionizable groups. On the other hand, EDprints models are more robust toward subtle rearrangements of chemical groups and more suitable for screening against reference molecules with fused ring systems than MOLPRINT 2D and FCFP-4. EDprints is furthermore the fastest method under investigation in comparing fingerprints (average 56-233-fold increase in speed), which makes it highly suitable for all-against-all similarity searches and for repetitive virtual screening against large chemical databases of millions of compounds.

  9. Virtualization

    NASA Astrophysics Data System (ADS)

    Garg, Vikas

    2012-11-01

    The main aim of the research was to get the knowledge of present trends and technologies used in it field. Virtualization Allows multiple applications to run in isolation within virtual machines on the same physical machine. Virtualization provides direct access to the hardware resources to give you much greater performance than software emulation. VMware provides hardware virtualization that presents a complete x86 platform to the virtual machine. By doing this project we get an opportunity to learn about an emerging field of IT Sector. They also gave us the details of project like 'Storage Vmmotioní on which HP is currently working.

  10. Virtual Instrument Systems in Reality (VISIR) for Remote Wiring and Measurement of Electronic Circuits on Breadboard

    ERIC Educational Resources Information Center

    Tawfik, M.; Sancristobal, E.; Martin, S.; Gil, R.; Diaz, G.; Colmenar, A.; Peire, J.; Castro, M.; Nilsson, K.; Zackrisson, J.; Hakansson, L.; Gustavsson, I.

    2013-01-01

    This paper reports on a state-of-the-art remote laboratory project called Virtual Instrument Systems in Reality (VISIR). VISIR allows wiring and measuring of electronic circuits remotely on a virtual workbench that replicates physical circuit breadboards. The wiring mechanism is developed by means of a relay switching matrix connected to a PCI…

  11. Virtual Instrument Systems in Reality (VISIR) for Remote Wiring and Measurement of Electronic Circuits on Breadboard

    ERIC Educational Resources Information Center

    Tawfik, M.; Sancristobal, E.; Martin, S.; Gil, R.; Diaz, G.; Colmenar, A.; Peire, J.; Castro, M.; Nilsson, K.; Zackrisson, J.; Hakansson, L.; Gustavsson, I.

    2013-01-01

    This paper reports on a state-of-the-art remote laboratory project called Virtual Instrument Systems in Reality (VISIR). VISIR allows wiring and measuring of electronic circuits remotely on a virtual workbench that replicates physical circuit breadboards. The wiring mechanism is developed by means of a relay switching matrix connected to a PCI…

  12. QR Codes as Finding Aides: Linking Electronic and Print Library Resources

    ERIC Educational Resources Information Center

    Kane, Danielle; Schneidewind, Jeff

    2011-01-01

    As part of a focused, methodical, and evaluative approach to emerging technologies, QR codes are one of many new technologies being used by the UC Irvine Libraries. QR codes provide simple connections between print and virtual resources. In summer 2010, a small task force began to investigate how QR codes could be used to provide information and…

  13. QR Codes as Finding Aides: Linking Electronic and Print Library Resources

    ERIC Educational Resources Information Center

    Kane, Danielle; Schneidewind, Jeff

    2011-01-01

    As part of a focused, methodical, and evaluative approach to emerging technologies, QR codes are one of many new technologies being used by the UC Irvine Libraries. QR codes provide simple connections between print and virtual resources. In summer 2010, a small task force began to investigate how QR codes could be used to provide information and…

  14. News of the Year. LJ News Report: Victories Muted by Money Worries; The Year in K-12 Libraries: School Librarians Redefine Themselves; Publishing in 2002: Few Trends Emerge from a Year of Ups and Downs.

    ERIC Educational Resources Information Center

    Minkel, Walter; Milliot, Jim

    2003-01-01

    Includes three articles: one reviews top stories from "Library Journal" regarding budget problems, salaries and recruitment, privacy, legal issues, virtual reference, electronic books, distance education, special libraries, and scholarly innovation; one discusses school library issues, including layoffs, Internet concerns, and…

  15. News of the Year. LJ News Report: Victories Muted by Money Worries; The Year in K-12 Libraries: School Librarians Redefine Themselves; Publishing in 2002: Few Trends Emerge from a Year of Ups and Downs.

    ERIC Educational Resources Information Center

    Minkel, Walter; Milliot, Jim

    2003-01-01

    Includes three articles: one reviews top stories from "Library Journal" regarding budget problems, salaries and recruitment, privacy, legal issues, virtual reference, electronic books, distance education, special libraries, and scholarly innovation; one discusses school library issues, including layoffs, Internet concerns, and…

  16. Communication, Collaboration, and Enhancing the Learning Experience: Developing a Collaborative Virtual Enquiry Service in University Libraries in the North of England

    ERIC Educational Resources Information Center

    Jolly, Liz; White, Sue

    2016-01-01

    This article uses the case study of developing a collaborative "out-of-hours" virtual enquiry service by members of the Northern Collaboration Group of academic libraries in the north of England to explore the importance of communication and collaboration between academic library services in enhancing student learning. Set within the…

  17. Communication, Collaboration, and Enhancing the Learning Experience: Developing a Collaborative Virtual Enquiry Service in University Libraries in the North of England

    ERIC Educational Resources Information Center

    Jolly, Liz; White, Sue

    2016-01-01

    This article uses the case study of developing a collaborative "out-of-hours" virtual enquiry service by members of the Northern Collaboration Group of academic libraries in the north of England to explore the importance of communication and collaboration between academic library services in enhancing student learning. Set within the…

  18. Virtual screening using combinatorial cyclic peptide libraries reveals protein interfaces readily targetable by cyclic peptides.

    PubMed

    Duffy, Fergal J; O'Donovan, Darragh; Devocelle, Marc; Moran, Niamh; O'Connell, David J; Shields, Denis C

    2015-03-23

    Protein-protein and protein-peptide interactions are responsible for the vast majority of biological functions in vivo, but targeting these interactions with small molecules has historically been difficult. What is required are efficient combined computational and experimental screening methods to choose among a number of potential protein interfaces worthy of targeting lead macrocyclic compounds for further investigation. To achieve this, we have generated combinatorial 3D virtual libraries of short disulfide-bonded peptides and compared them to pharmacophore models of important protein-protein and protein-peptide structures, including short linear motifs (SLiMs), protein-binding peptides, and turn structures at protein-protein interfaces, built from 3D models available in the Protein Data Bank. We prepared a total of 372 reference pharmacophores, which were matched against 108,659 multiconformer cyclic peptides. After normalization to exclude nonspecific cyclic peptides, the top hits notably are enriched for mimetics of turn structures, including a turn at the interaction surface of human α thrombin, and also feature several protein-binding peptides. The top cyclic peptide hits also cover the critical "hot spot" interaction sites predicted from the interaction crystal structure. We have validated our method by testing cyclic peptides predicted to inhibit thrombin, a key protein in the blood coagulation pathway of important therapeutic interest, identifying a cyclic peptide inhibitor with lead-like activity. We conclude that protein interfaces most readily targetable by cyclic peptides and related macrocyclic drugs may be identified computationally among a set of candidate interfaces, accelerating the choice of interfaces against which lead compounds may be screened.

  19. Ligand efficiency based approach for efficient virtual screening of compound libraries.

    PubMed

    Ke, Yi-Yu; Coumar, Mohane Selvaraj; Shiao, Hui-Yi; Wang, Wen-Chieh; Chen, Chieh-Wen; Song, Jen-Shin; Chen, Chun-Hwa; Lin, Wen-Hsing; Wu, Szu-Huei; Hsu, John T A; Chang, Chung-Ming; Hsieh, Hsing-Pang

    2014-08-18

    Here we report for the first time the use of fit quality (FQ), a ligand efficiency (LE) based measure for virtual screening (VS) of compound libraries. The LE based VS protocol was used to screen an in-house database of 125,000 compounds to identify aurora kinase A inhibitors. First, 20 known aurora kinase inhibitors were docked to aurora kinase A crystal structure (PDB ID: 2W1C); and the conformations of docked ligand were used to create a pharmacophore (PH) model. The PH model was used to screen the database compounds, and rank (PH rank) them based on the predicted IC50 values. Next, LE_Scale, a weight-dependant LE function, was derived from 294 known aurora kinase inhibitors. Using the fit quality (FQ = LE/LE_Scale) score derived from the LE_Scale function, the database compounds were reranked (PH_FQ rank) and the top 151 (0.12% of database) compounds were assessed for aurora kinase A inhibition biochemically. This VS protocol led to the identification of 7 novel hits, with compound 5 showing aurora kinase A IC50 = 1.29 μM. Furthermore, testing of 5 against a panel of 31 kinase reveals that it is selective toward aurora kinase A & B, with <50% inhibition for other kinases at 10 μM concentrations and is a suitable candidate for further development. Incorporation of FQ score in the VS protocol not only helped identify a novel aurora kinase inhibitor, 5, but also increased the hit rate of the VS protocol by improving the enrichment factor (EF) for FQ based screening (EF = 828), compared to PH based screening (EF = 237) alone. The LE based VS protocol disclosed here could be applied to other targets for hit identification in an efficient manner.

  20. Novel in situ method for locating virtual source in high-rate electron-beam evaporation

    NASA Astrophysics Data System (ADS)

    Bhatia, M. S.

    1994-07-01

    The concept of virtual source simplifies calculation of thickness distribution on extended substrates in high rate vacuum coating employing electron-beam heating. The height of the point (virtual source), from which vapor can be assumed to emanate in accordance with Knudsen's cosine law, to yield the experimentally obtained thickness distribution, is calculated and this establishes the position of virtual source. Such as post facto determination is cumbersome as it is valid for the prescribed material evaporating at a certain rate in a specified geometry. A change in any of these entails a fresh measurement. Experimenters who use a large number of materials and deposit at different rates therefore have to carry out a number of trials before they can locate the virtual source at the desired deposition parameters. An in situ method for obtaining virtual source position can go a long way in reducing the labor of these experiments. A novel in situ method is described to locate the virtual source.

  1. Putting the Medical Library Online: Electronic Bulletin Boards. . . and Beyond.

    ERIC Educational Resources Information Center

    Kittle, Paul W.

    1985-01-01

    Describes use of microcomputers with system called "TBBS" ("The Bread Board System") at Loma Linda University Medical Center to allow users enhanced services from home, whether library facilities are open or not. Flexibility and security, dialing into medical library, and suggestions for setting up similar computerized…

  2. Putting the Medical Library Online: Electronic Bulletin Boards. . . and Beyond.

    ERIC Educational Resources Information Center

    Kittle, Paul W.

    1985-01-01

    Describes use of microcomputers with system called "TBBS" ("The Bread Board System") at Loma Linda University Medical Center to allow users enhanced services from home, whether library facilities are open or not. Flexibility and security, dialing into medical library, and suggestions for setting up similar computerized…

  3. Information Technology in the Virtual Library: Leadership in Times of Change.

    ERIC Educational Resources Information Center

    Glogoff, Stuart

    2001-01-01

    Describes the impact of networked information technology environments on libraries, users, and library competitors, focusing on the leadership role of library administrators. Discusses the network generation as agents of change; transforming learning; the impact of networked information; the impact on the workplace; and emerging technologies.…

  4. Working in the Virtual Stacks: The New Library and Information Science

    ERIC Educational Resources Information Center

    Kane, Laura Townsend, Ed.

    2011-01-01

    Thanks in part to technology, the boundaries of library positions are dissolving. It is no longer practical to discuss the profession in terms of traditional library types, and in today's library, the relationship between librarians and technology is stronger than ever. In this informative volume, veteran author Laura Townsend Kane interviews…

  5. Working in the Virtual Stacks: The New Library and Information Science

    ERIC Educational Resources Information Center

    Kane, Laura Townsend, Ed.

    2011-01-01

    Thanks in part to technology, the boundaries of library positions are dissolving. It is no longer practical to discuss the profession in terms of traditional library types, and in today's library, the relationship between librarians and technology is stronger than ever. In this informative volume, veteran author Laura Townsend Kane interviews…

  6. Experimental investigation of virtual cathode sheath in the presence of secondary electrons produced by streaming ions

    NASA Astrophysics Data System (ADS)

    Li, Wei; Ma, J. X.; Li, Jing-ju; Wei, Zi-an

    2012-11-01

    The potential profiles near a negatively biased stainless steel plate or mesh immersed in an unmagnetized weakly collisional plasma were investigated experimentally. The results show that deep virtual cathode structures arise inside the sheath region in front of the plate caused by secondary electrons produced by streaming ions hitting the surface of the plate. The characteristics of the virtual cathode depend on the incoming ion energy, neutral gas pressure, and bulk plasma density. In addition, the replacement of the plate with the mesh results in the suppression of the virtual cathode because of the equivalent reduction in the secondary electron yield.

  7. Development and experimental test of support vector machines virtual screening method for searching Src inhibitors from large compound libraries

    PubMed Central

    2012-01-01

    Background Src plays various roles in tumour progression, invasion, metastasis, angiogenesis and survival. It is one of the multiple targets of multi-target kinase inhibitors in clinical uses and trials for the treatment of leukemia and other cancers. These successes and appearances of drug resistance in some patients have raised significant interest and efforts in discovering new Src inhibitors. Various in-silico methods have been used in some of these efforts. It is desirable to explore additional in-silico methods, particularly those capable of searching large compound libraries at high yields and reduced false-hit rates. Results We evaluated support vector machines (SVM) as virtual screening tools for searching Src inhibitors from large compound libraries. SVM trained and tested by 1,703 inhibitors and 63,318 putative non-inhibitors correctly identified 93.53%~ 95.01% inhibitors and 99.81%~ 99.90% non-inhibitors in 5-fold cross validation studies. SVM trained by 1,703 inhibitors reported before 2011 and 63,318 putative non-inhibitors correctly identified 70.45% of the 44 inhibitors reported since 2011, and predicted as inhibitors 44,843 (0.33%) of 13.56M PubChem, 1,496 (0.89%) of 168 K MDDR, and 719 (7.73%) of 9,305 MDDR compounds similar to the known inhibitors. Conclusions SVM showed comparable yield and reduced false hit rates in searching large compound libraries compared to the similarity-based and other machine-learning VS methods developed from the same set of training compounds and molecular descriptors. We tested three virtual hits of the same novel scaffold from in-house chemical libraries not reported as Src inhibitor, one of which showed moderate activity. SVM may be potentially explored for searching Src inhibitors from large compound libraries at low false-hit rates. PMID:23173901

  8. Library+

    ERIC Educational Resources Information Center

    Merrill, Alex

    2011-01-01

    This article discusses possible future directions for academic libraries in the post Web/Library 2.0 world. These possible directions include areas such as data literacy, linked data sets, and opportunities for libraries in support of digital humanities. The author provides a brief sketch of the background information regarding the topics and…

  9. Electronic Collection Management: Completing the Cycle--Experiences at Two Libraries

    ERIC Educational Resources Information Center

    Hiott, Judith; Beasley, Carla

    2005-01-01

    The development of the Internet and the online collections accessed by it has created major adjustments in all library functions, including collection management and budgeting. The authors share how two public libraries have come full circle in electronic collection management, beginning with early selection, followed by current weeding programs…

  10. The Electronic Library: The Student/Scholar Workstation, CD-ROM and Hypertext.

    ERIC Educational Resources Information Center

    Triebwasser, Marc A.

    Predicting that a large component of the library of the not so distant future will be an electronic network of file servers where information is stored for access by personal computer workstations in remote locations as well as the library, this paper discusses innovative computer technologies--particularly CD-ROM (Compact Disk-Read Only Memory)…

  11. Elin@: Electronic Library Information Navigator--Towards the "One Stop Shop" Information

    ERIC Educational Resources Information Center

    Alwerud, Anna; Jorgensen, Lotte

    2005-01-01

    Libraries subscribe to thousands of electronic journals and they are difficult for end-users to find. Journal and publisher interfaces and functionalities differ considerably. The recent development in e-media calls for central management of the resources. Lund University Libraries' Head Office has developed a service for presentation and…

  12. The Application of Centralized Text Editing and Electronic Mail Systems in Libraries: The CMU Experience.

    ERIC Educational Resources Information Center

    Michalak, Thomas J.

    1984-01-01

    Describes Carnegie-Mellon University Libraries' utilization of three software packages resident on the University's central computers: text editing, text formatting, and electronic mail. Advantages of utilizing central computing resources, introduction of and training in computing systems within libraries, specific applications, and advantages and…

  13. Marketing of Academic Library Services through Social Networking Sites: Implications of Electronic Word-of-Mouth

    ERIC Educational Resources Information Center

    Siddike, Md. Abul Kalam; Kiran, K.

    2015-01-01

    The main objective of this study is to investigate the perceptions of academic librarians towards the marketing of library services through social networking sites (SNSs) and their understanding of using electronic word-of-mouth (eWOM) as a marketing tool in academic libraries. This study follows a qualitative data-gathering approach of structured…

  14. Managing Electronic Resources: A Survey of Current Practices in Academic Libraries.

    ERIC Educational Resources Information Center

    Shaw, Beth Hansen

    This document reports results of an online survey that examined practices and procedures in the management of electronic resources in 65 academic library reference departments. Responses are related to: (1) student population; (2) library use by community people; (3) number of public access workstations, workstations with World Wide Web access,…

  15. Elin@: Electronic Library Information Navigator--Towards the "One Stop Shop" Information

    ERIC Educational Resources Information Center

    Alwerud, Anna; Jorgensen, Lotte

    2005-01-01

    Libraries subscribe to thousands of electronic journals and they are difficult for end-users to find. Journal and publisher interfaces and functionalities differ considerably. The recent development in e-media calls for central management of the resources. Lund University Libraries' Head Office has developed a service for presentation and…

  16. Public Access to Electronic Federal Depository Information in Regional Depository Libraries.

    ERIC Educational Resources Information Center

    Ford, Stephanie

    This study describes regional depository institutions, the organization of their document collections, the staffing of their documents departments, and factors relevant to their providing access to electronic government information. Surveys were sent to 53 regional depository libraries in March 1995. Forty-one of the 53 libraries responded (77%…

  17. A Study of Current Practices of Selected Libraries in Cataloguing Electronic Journals.

    ERIC Educational Resources Information Center

    ChaPudhry, Abdus Sattar; Periasamy, Makeswary

    2001-01-01

    Describes a study that reviewed MARC records and online policy documents of selected libraries to study the approaches taken by libraries worldwide to catalog electronic journals. Topics include priorities for cataloging; record types; online versus print versions; guidelines used; and best practices. (Author/LRW)

  18. Developing Partnerships to Create Electronic Reserves at the University of Kansas Libraries

    ERIC Educational Resources Information Center

    Burich, Nancy J.; Rholes, Julia

    2003-01-01

    Today, it is advantageous for academic libraries to look outside their own organizations to other potential campus and commercial partners when considering new services. This case study describes the planning and implementation of electronic reserves at the University of Kansas Libraries, including the integration of two commercial partners,…

  19. The Electronic Library: The Student/Scholar Workstation, CD-ROM and Hypertext.

    ERIC Educational Resources Information Center

    Triebwasser, Marc A.

    Predicting that a large component of the library of the not so distant future will be an electronic network of file servers where information is stored for access by personal computer workstations in remote locations as well as the library, this paper discusses innovative computer technologies--particularly CD-ROM (Compact Disk-Read Only Memory)…

  20. Electronic Journals: Managing and Educating for a Changing Culture in Academic Libraries.

    ERIC Educational Resources Information Center

    Ashcroft, Linda; McIvor, Stephanie

    2001-01-01

    Describes a research project that focused on the evaluation and promotion of electronic journals in academic libraries in the United Kingdom and in North America. Topics include changing role of the serials librarian; costs; consortia purchasing; relationship between libraries and publishers; and collaboration to ensure interoperability.…

  1. Data Needs and Use of Electronic Resources and Services at Academic Research Libraries.

    ERIC Educational Resources Information Center

    Shim, Wonsik; McClure, Charles R.

    2002-01-01

    Discusses the ARL (Association of Research Libraries) E-Metrics project that is investigating problems related to collecting and using data for electronic materials and services. Describes a survey of libraries that focused on data collection activities and showed a lack of preparation as well as a lack of consistent statistics from database…

  2. Introduction of Electronic Book Ordering with EDIFACT in a Special Library: A Case Study.

    ERIC Educational Resources Information Center

    Stadler, Peter; Thomas, Martin; Mernke, Ernst

    1999-01-01

    Describes book ordering procedures at a German pharmaceutical library using the Electronic Data Interchange for Administration, Commerce and Transport (EDIFACT) guidelines developed by the United Nations. Topics include advantages for libraries and for the book trade, changes needed in software, productivity gains, and EDIFACT versus the Internet.…

  3. Electronic Collection Management: Completing the Cycle--Experiences at Two Libraries

    ERIC Educational Resources Information Center

    Hiott, Judith; Beasley, Carla

    2005-01-01

    The development of the Internet and the online collections accessed by it has created major adjustments in all library functions, including collection management and budgeting. The authors share how two public libraries have come full circle in electronic collection management, beginning with early selection, followed by current weeding programs…

  4. Developing Partnerships to Create Electronic Reserves at the University of Kansas Libraries

    ERIC Educational Resources Information Center

    Burich, Nancy J.; Rholes, Julia

    2003-01-01

    Today, it is advantageous for academic libraries to look outside their own organizations to other potential campus and commercial partners when considering new services. This case study describes the planning and implementation of electronic reserves at the University of Kansas Libraries, including the integration of two commercial partners,…

  5. Marketing of Academic Library Services through Social Networking Sites: Implications of Electronic Word-of-Mouth

    ERIC Educational Resources Information Center

    Siddike, Md. Abul Kalam; Kiran, K.

    2015-01-01

    The main objective of this study is to investigate the perceptions of academic librarians towards the marketing of library services through social networking sites (SNSs) and their understanding of using electronic word-of-mouth (eWOM) as a marketing tool in academic libraries. This study follows a qualitative data-gathering approach of structured…

  6. OCTANET--an electronic library network: I. Design and development.

    PubMed Central

    Johnson, M F; Pride, R B

    1983-01-01

    The design and development of the OCTANET system for networking among medical libraries in the midcontinental region is described. This system's features and configuration may be attributed, at least in part, to normal evolution of technology in library networking, remote access to computers, and development of machine-readable data bases. Current functions and services of the system are outlined and implications for future developments in computer-based networking are discussed. PMID:6860825

  7. Computational redesign of bacterial biotin carboxylase inhibitors using structure-based virtual screening of combinatorial libraries.

    PubMed

    Brylinski, Michal; Waldrop, Grover L

    2014-04-02

    As the spread of antibiotic resistant bacteria steadily increases, there is an urgent need for new antibacterial agents. Because fatty acid synthesis is only used for membrane biogenesis in bacteria, the enzymes in this pathway are attractive targets for antibacterial agent development. Acetyl-CoA carboxylase catalyzes the committed and regulated step in fatty acid synthesis. In bacteria, the enzyme is composed of three distinct protein components: biotin carboxylase, biotin carboxyl carrier protein, and carboxyltransferase. Fragment-based screening revealed that amino-oxazole inhibits biotin carboxylase activity and also exhibits antibacterial activity against Gram-negative organisms. In this report, we redesigned previously identified lead inhibitors to expand the spectrum of bacteria sensitive to the amino-oxazole derivatives by including Gram-positive species. Using 9,411 small organic building blocks, we constructed a diverse combinatorial library of 1.2×10⁸ amino-oxazole derivatives. A subset of 9×10⁶ of these compounds were subjected to structure-based virtual screening against seven biotin carboxylase isoforms using similarity-based docking by eSimDock. Potentially broad-spectrum antibiotic candidates were selected based on the consensus ranking by several scoring functions including non-linear statistical models implemented in eSimDock and traditional molecular mechanics force fields. The analysis of binding poses of the top-ranked compounds docked to biotin carboxylase isoforms suggests that: (1) binding of the amino-oxazole anchor is stabilized by a network of hydrogen bonds to residues 201, 202 and 204; (2) halogenated aromatic moieties attached to the amino-oxazole scaffold enhance interactions with a hydrophobic pocket formed by residues 157, 169, 171 and 203; and (3) larger substituents reach deeper into the binding pocket to form additional hydrogen bonds with the side chains of residues 209 and 233. These structural insights into drug

  8. Lessons learned from evaluation of the use of the National electronic Library of Infection.

    PubMed

    Madle, Gemma; Kostkova, Patty; Mani-Saada, Jane; Roy, Anjana

    2006-06-01

    The National electronic Library of Infection (NeLI: http://www.neli.org.uk) in the UK is a freely available portal to key evidence and guidelines in the infectious disease field. This paper discusses 5 years of evaluation of the pilot library and how this evaluation informed design of the new library website. The importance of combining qualitative and quantitative evaluation is highlighted and the results of web access logs analysis, free text search query analysis and an online user survey are compared. The paper concludes with a discussion of lessons learned for future development and evaluation of this Internet digital library.

  9. Remote Electronic Resources and the OPAC: Illustrated by the Unisa Library Experience.

    ERIC Educational Resources Information Center

    Van der Merwe, Ina; Van Eeden, Welna; Hartzer, Sandra

    This paper describes the Unisa (University of South Africa) Library's experience with cataloging remote electronic resources, including electronic journals, electronic text files, online databases, digital images, Unisa campus Web sites, and mailing list discussions. The first section discusses the decision to add bibliographic references for…

  10. Hyper-Books and Visual-Books in an Electronic Library.

    ERIC Educational Resources Information Center

    Landoni, Monica; And Others

    1993-01-01

    Examines the development of electronic books and traditional libraries in relation to the history of books and publishing. An ongoing project is described that is developing two forms of electronic books: hyper-books (built from paper books) and visual-books (built from electronic texts). (22 references) (EAM)

  11. Electronic Publishing and Its Impact on Books and Libraries: An Overview with Comment and Recommendation.

    ERIC Educational Resources Information Center

    Wang, Chih

    1986-01-01

    Reviews definitions and the scope, history, technological capabilities, and other significant issues of electronic publishing. Advantages and disadvantages of electronic publishing are compared to those of traditional publishing, and possible future impacts of electronic publishing on books and libraries are considered. (CDD)

  12. Development and implementation of an electronic library tour for the NASA Langley Technical Library. M.S. Thesis, North Carolina Univ., Jul. 1994

    NASA Technical Reports Server (NTRS)

    Rinker, Nancy A.

    1994-01-01

    The role of librarians today is drastically influenced by the changing nature of information and library services. The museum-like libraries of yesterday are a thing of the past: today's libraries are bustling with life, activity, and the sounds of new technologies. Libraries are replacing their paper card catalogs with state-of-the-art online systems, which provide faster and more comprehensive search capabilities. Even the resources themselves are changing. New formats for information, such as CD-ROM's, are becoming popular for all types of publications, from bibliographic tools to encyclopedias to electronic journals, even replacing print materials completely in some cases. Today it is almost impossible to walk into a library and find the information you need without coming into contact with at least one computer system. Librarians are not only struggling to keep up with the technological advancements of the day, but they are becoming information intermediaries: they must teach library users how to use all of the new systems and electronic resources. Not surprisingly, bibliographic instruction itself has taken on a new look and feel in these electronically advanced libraries. Many libraries are experimenting with the development of expert systems and other computer aided instruction interfaces for teaching patrons how to use the library and its resources. One popular type of interface in library instruction programs is hypertext, which utilizes 'stacks' or linked pages of information. Hypertext stacks can incorporate color graphics along with text to provide a more interesting interface and entice users into trying out the system. Another advantage of hypertext is that it is generally easy to use, even for those unfamiliar with computers. As such, it lends itself well to application in libraries, which often serve a broad range of clientele. This paper will discuss the design, development, and implementation of a hypertext library tour in a special library

  13. New Library, New Librarian, New Student: Using LibGuides to Reach the Virtual Student

    ERIC Educational Resources Information Center

    Roberts, Sara; Hunter, Dwight

    2011-01-01

    This article examines the virtual pathfinder and its relationship with distance education students. Various topics are addressed in relation to virtual students, LibGuides and collaborative efforts between librarians and teaching faculty. A brief history of the subject guide is presented, advantages and disadvantages of LibGuides are discussed and…

  14. New Library, New Librarian, New Student: Using LibGuides to Reach the Virtual Student

    ERIC Educational Resources Information Center

    Roberts, Sara; Hunter, Dwight

    2011-01-01

    This article examines the virtual pathfinder and its relationship with distance education students. Various topics are addressed in relation to virtual students, LibGuides and collaborative efforts between librarians and teaching faculty. A brief history of the subject guide is presented, advantages and disadvantages of LibGuides are discussed and…

  15. What Do Context Aware Electronic Alerts from Virtual Learning Environments Tell Us about User Time & Location?

    ERIC Educational Resources Information Center

    Crane, Laura; Benachour, Phillip

    2013-01-01

    The paper describes the analysis of user location and time stamp information automatically logged when students receive and interact with electronic updates from the University's virtual learning environment. The electronic updates are sent to students' mobile devices using RSS feeds. The mobile reception of such information can be received in…

  16. The Draper Gopher: A Team Approach to Building a Virtual Library.

    ERIC Educational Resources Information Center

    Rotman, Laurie; And Others

    1995-01-01

    The Draper Laboratory Library created the Draper Gopher in response to the following factors: library downsizing, the computer services department's changing role, customer needs, and developments in technology affecting the information environment. Results of its implementation include user-focused reference services; increased interlibrary loan…

  17. Learning to Provide 3D Virtual Reference: A Library Science Assignment

    ERIC Educational Resources Information Center

    Johnson, Megan; Purpur, Geraldine; Abbott, Lisa T.

    2009-01-01

    In spring semester 2009, two of the authors taught LIB 5020--Information Sources & Services to graduate library science students at Appalachian State University. The course covers information seeking patterns and provides an overview of reference services. The course is also designed to examine and evaluate library reference materials and…

  18. Changing a Cultural Icon: The Academic Library as a Virtual Destination

    ERIC Educational Resources Information Center

    Campbell, Jerry D.

    2006-01-01

    Academic libraries today are complex institutions with multiple roles and a host of related operations and services developed over the years. Yet their fundamental purpose has remained the same: to provide access to trustworthy, authoritative knowledge. Consequently, academic libraries--along with their private and governmental counterparts--have…

  19. Learning to Provide 3D Virtual Reference: A Library Science Assignment

    ERIC Educational Resources Information Center

    Johnson, Megan; Purpur, Geraldine; Abbott, Lisa T.

    2009-01-01

    In spring semester 2009, two of the authors taught LIB 5020--Information Sources & Services to graduate library science students at Appalachian State University. The course covers information seeking patterns and provides an overview of reference services. The course is also designed to examine and evaluate library reference materials and…

  20. Identification of novel malarial cysteine protease inhibitors using structure-based virtual screening of a focused cysteine protease inhibitor library.

    PubMed

    Shah, Falgun; Mukherjee, Prasenjit; Gut, Jiri; Legac, Jennifer; Rosenthal, Philip J; Tekwani, Babu L; Avery, Mitchell A

    2011-04-25

    Malaria, in particular that caused by Plasmodium falciparum , is prevalent across the tropics, and its medicinal control is limited by widespread drug resistance. Cysteine proteases of P. falciparum , falcipain-2 (FP-2) and falcipain-3 (FP-3), are major hemoglobinases, validated as potential antimalarial drug targets. Structure-based virtual screening of a focused cysteine protease inhibitor library built with soft rather than hard electrophiles was performed against an X-ray crystal structure of FP-2 using the Glide docking program. An enrichment study was performed to select a suitable scoring function and to retrieve potential candidates against FP-2 from a large chemical database. Biological evaluation of 50 selected compounds identified 21 diverse nonpeptidic inhibitors of FP-2 with a hit rate of 42%. Atomic Fukui indices were used to predict the most electrophilic center and its electrophilicity in the identified hits. Comparison of predicted electrophilicity of electrophiles in identified hits with those in known irreversible inhibitors suggested the soft-nature of electrophiles in the selected target compounds. The present study highlights the importance of focused libraries and enrichment studies in structure-based virtual screening. In addition, few compounds were screened against homologous human cysteine proteases for selectivity analysis. Further evaluation of structure-activity relationships around these nonpeptidic scaffolds could help in the development of selective leads for antimalarial chemotherapy.

  1. The ecological and construct validity of a newly developed measure of executive function: the Virtual Library Task.

    PubMed

    Renison, Belinda; Ponsford, Jennie; Testa, Renee; Richardson, Barry; Brownfield, Kylie

    2012-05-01

    Virtual reality (VR) assessment paradigms have the potential to address the limited ecological validity of pen and paper measures of executive function (EF) and the pragmatic and reliability issues associated with functional measures. To investigate the ecological validity and construct validity of a newly developed VR measure of EF, the Virtual Library Task (VLT); a real life analogous task--the Real Library Task (RLT); and five neuropsychological measures of EF were administered to 30 patients with traumatic brain injury (TBI) and 30 healthy Controls. Significant others for each participant also completed the Dysexecutive Questionnaire (DEX), which is a behavioral rating scale of everyday EF. Performances on the VLT and the RLT were significantly positively correlated indicating that VR performance is similar to real world performance. The TBI group performed significantly worse than the Control group on the VLT and the Modified Six Elements Test (MSET) but the other four neuropsychological measures of EF failed to differentiate the groups. Both the MSET and the VLT significantly predicted everyday EF suggesting that they are both ecologically valid tools for the assessment of EF. The VLT has the advantage over the MSET of providing objective measurement of individual components of EF.

  2. On various metrics used for validation of predictive QSAR models with applications in virtual screening and focused library design.

    PubMed

    Roy, Kunal; Mitra, Indrani

    2011-07-01

    Quantitative structure-activity relationships (QSARs) have important applications in drug discovery research, environmental fate modeling, property prediction, etc. Validation has been recognized as a very important step for QSAR model development. As one of the important objectives of QSAR modeling is to predict activity/property/toxicity of new chemicals falling within the domain of applicability of the developed models and QSARs are being used for regulatory decisions, checking reliability of the models and confidence of their predictions is a very important aspect, which can be judged during the validation process. One prime application of a statistically significant QSAR model is virtual screening for molecules with improved potency based on the pharmacophoric features and the descriptors appearing in the QSAR model. Validated QSAR models may also be utilized for design of focused libraries which may be subsequently screened for the selection of hits. The present review focuses on various metrics used for validation of predictive QSAR models together with an overview of the application of QSAR models in the fields of virtual screening and focused library design for diverse series of compounds with citation of some recent examples.

  3. Evidence against a universal electron-beam-induced virtual temperature in graphene

    NASA Astrophysics Data System (ADS)

    Börner, Pia; Kaiser, Ute; Lehtinen, Ossi

    2016-04-01

    The continuous electron bombardment of a sample during transmission electron microscopy (TEM) drives atomic-scale transformations. In earlier studies the transformations appeared to proceed as if the sample was held at an elevated temperature, and, indeed, the hypothesis of an electron-beam-induced virtual temperature has gained traction in the scientific community. However, the sample is not significantly heated by the electron beam, meaning the processes are not activated by thermal vibrations. Instead, individual collisions between the electrons and the target atoms, and/or excitations of the electronic system, lead to the observed transformations. It is not a priori clear what virtual temperature can be assigned to the conditions under the electron irradiation, or even if such a temperature can be defined at all. Here, we attempt to measure the virtual temperature, specific to this system, by comparing the relative population of the three different divacancy defect states in single-layer graphene to the Boltzmann distribution using calculated energy levels of the defect states. The experiment is conducted using aberration-corrected high-resolution TEM at an acceleration voltage of 80 kV. Atomistic simulations are used to learn about the energetics of the defects. We find that the measured populations cannot be fitted to the Boltzmann distribution, and consequently no universal virtual temperature can be assigned to the system.

  4. Design and Development of a Network-Based Electronic Library.

    ERIC Educational Resources Information Center

    Larson, Ray R.

    1994-01-01

    Describes collaboration between the University of California at Berkeley and four other universities to develop interoperable servers containing each participant's Computer Science Technical Reports and to make them available over the Internet using standard protocols. The proposed library architecture, approaches to indexing and retrieval, and…

  5. Electronic Bowdlerites: Censorship and Libraries in the Information Age.

    ERIC Educational Resources Information Center

    Sager, Don

    1997-01-01

    The librarians and directors contributing to this article review current trends in censorship, and describe strategies, policies, and practices they would recommend. Discussion includes selection policies, educating the public, new technologies and materials, and the Internet. All agree on the library's responsibility of preserving intellectual…

  6. Comparative molecular surface analysis (CoMSA) for virtual combinatorial library screening of styrylquinoline HIV-1 blocking agents.

    PubMed

    Niedbala, Halina; Polanski, Jaroslaw; Gieleciak, Rafal; Musiol, Robert; Tabak, Dominik; Podeszwa, Barbara; Bak, Andrzej; Palka, Anna; Mouscadet, Jean-Francois; Gasteiger, Johann; Le Bret, Marc

    2006-12-01

    We used comparative molecular surface analysis to design molecules for the synthesis as part of the search for new HIV-1 integrase inhibitors. We analyzed the virtual combinatorial library (VCL) constituted from various moieties of styrylquinoline and styrylquinazoline inhibitors. Since imines can be applied in a strategy of dynamic combinatorial chemistry (DCC), we also tested similar compounds in which the -C=N- or -N=C- linker connected the heteroaromatic and aromatic moieties. We then used principal component analysis (PCA) or self-organizing maps (SOM), namely, the Kohonen neural networks to obtain a clustering plot analyzing the diversity of the VCL formed. Previously synthesized compounds of known activity, used as molecular probes, were projected onto this plot, which provided a set of promising virtual drugs. Moreover, we further modified the above mentioned VCL to include the single bond linker -C-N- or -N-C-. This allowed increasing compound stability but expanded also the diversity between the available molecular probes and virtual targets. The application of the CoMSA with SOM indicated important differences between such compounds and active molecular probes. We synthesized such compounds to verify the computational predictions.

  7. New Electronic Scholarship and Libraries; Or the Medium Became the Message.

    ERIC Educational Resources Information Center

    Rogers, Sharon J.; Hurt, Charlene S.

    1998-01-01

    Reviews the changes in scholarly publishing from the mid-1980s development of the Online Computer Library Center (OCLC) Electronic Information Delivery Online System (EIDOS). Highlights selected initiatives in electronic publishing: Project MUSE, JSTOR, Academic Press' IDEAL, and Springer-Verlag's LINK Information service. (PEN)

  8. Print and Electronic Resources: Usage Statistics at Guru Gobind Singh Indraprastha University Library

    ERIC Educational Resources Information Center

    Kapoor, Kanta

    2010-01-01

    Purpose: The purpose of this paper is to quantify the use of electronic journals in comparison with the print collections in the Guru Gobind Singh Indraprastha University Library. Design/methodology/approach: A detailed analysis was made of the use of lending services, the Xerox facility and usage of electronic journals such as Science Direct,…

  9. Access to Electronic Government Information through the GPO's Depository Library Program: An Update.

    ERIC Educational Resources Information Center

    McClure, Charles R.

    This brief overview of recent policy initiatives--in addition to existing statutes and regulations--that may affect the Government Printing Office (GPO) Depository Library Program's (DLP) role in the dissemination of electronic government information identifies selected trends that may affect the public's access to electronic information through…

  10. The Training of Library and Information Staff in the Handling of Online Electronic Journals.

    ERIC Educational Resources Information Center

    Meadows, Jack; And Others

    1997-01-01

    Describes the creation of "InfoTrain," an experimental electronic journal to be used for training, and the initial use made of it and two commercial electronic journals by library and information students at Loughborough University (England), the University of South Australia, and the City University of London (England). (PEN)

  11. Print and Electronic Resources: Usage Statistics at Guru Gobind Singh Indraprastha University Library

    ERIC Educational Resources Information Center

    Kapoor, Kanta

    2010-01-01

    Purpose: The purpose of this paper is to quantify the use of electronic journals in comparison with the print collections in the Guru Gobind Singh Indraprastha University Library. Design/methodology/approach: A detailed analysis was made of the use of lending services, the Xerox facility and usage of electronic journals such as Science Direct,…

  12. Measuring the Economic Value of the Electronic Scientific Information Services in Portuguese Academic Libraries

    ERIC Educational Resources Information Center

    Melo, Luiza Baptista; Pires, Cesaltina Pacheco

    2011-01-01

    This article has three main objectives: i) to describe the use patterns of electronic and traditional resources in Portuguese academic libraries; ii) to estimate the value of the Portuguese electronic scientific information consortium b-on by using two alternative valuation methodologies; iii) to relate the use patterns with the valuation of b-on.…

  13. Measuring the Economic Value of the Electronic Scientific Information Services in Portuguese Academic Libraries

    ERIC Educational Resources Information Center

    Melo, Luiza Baptista; Pires, Cesaltina Pacheco

    2011-01-01

    This article has three main objectives: i) to describe the use patterns of electronic and traditional resources in Portuguese academic libraries; ii) to estimate the value of the Portuguese electronic scientific information consortium b-on by using two alternative valuation methodologies; iii) to relate the use patterns with the valuation of b-on.…

  14. New Electronic Scholarship and Libraries; Or the Medium Became the Message.

    ERIC Educational Resources Information Center

    Rogers, Sharon J.; Hurt, Charlene S.

    1998-01-01

    Reviews the changes in scholarly publishing from the mid-1980s development of the Online Computer Library Center (OCLC) Electronic Information Delivery Online System (EIDOS). Highlights selected initiatives in electronic publishing: Project MUSE, JSTOR, Academic Press' IDEAL, and Springer-Verlag's LINK Information service. (PEN)

  15. The Institute for Scientific Information Electronic Library Project: Partnering as the Predominant Approach.

    ERIC Educational Resources Information Center

    Trolley, Jacqueline H.; Cody, Julianne W.

    1997-01-01

    The Institute for Scientific Information Electronic Library Project (ELP) is a result of user demand for electronic access to scientific journal literature as well as to those journals themselves. This article describes the ELP; examines ELP's partnerships with technological organizations, publishers, librarians, and users; and discusses two core…

  16. Virtual screening filters for the design of type II p38 MAP kinase inhibitors: a fragment based library generation approach.

    PubMed

    Badrinarayan, Preethi; Sastry, G Narahari

    2012-04-01

    In this work, we introduce the development and application of a three-step scoring and filtering procedure for the design of type II p38 MAP kinase leads using allosteric fragments extracted from virtual screening hits. The design of the virtual screening filters is based on a thorough evaluation of docking methods, DFG-loop conformation, binding interactions and chemotype specificity of the 138 p38 MAP kinase inhibitors from Protein Data Bank bound to DFG-in and DFG-out conformations using Glide, GOLD and CDOCKER. A 40 ns molecular dynamics simulation with the apo, type I with DFG-in and type II with DFG-out forms was carried out to delineate the effects of structural variations on inhibitor binding. The designed docking-score and sub-structure filters were first tested on a dataset of 249 potent p38 MAP kinase inhibitors from seven diverse series and 18,842 kinase inhibitors from PDB, to gauge their capacity to discriminate between kinase and non-kinase inhibitors and likewise to selectively filter-in target-specific inhibitors. The designed filters were then applied in the virtual screening of a database of ten million (10⁷) compounds resulting in the identification of 100 hits. Based on their binding modes, 98 allosteric fragments were extracted from the hits and a fragment library was generated. New type II p38 MAP kinase leads were designed by tailoring the existing type I ATP site binders with allosteric fragments using a common urea linker. Target specific virtual screening filters can thus be easily developed for other kinases based on this strategy to retrieve target selective compounds. Copyright © 2012 Elsevier Inc. All rights reserved.

  17. An availability study of electronic articles in an academic health sciences library

    PubMed Central

    Crum, Janet A

    2011-01-01

    Objectives: The purposes of this study were: to determine the number of articles requested by library users that could be retrieved from the library's collection using the library catalog and link resolver, in other words, the availability rate; and to identify the nature and frequency of problems encountered in this process, so that the problems could be addressed and access to full-text articles could be improved. Methods: A sample of 414 requested articles was identified via link resolver log files. Library staff attempted to retrieve these articles using the library catalog and link resolver and documented access problems. Results: Staff were able to retrieve electronic full text for 310 articles using the catalog. An additional 21 articles were available in print, for an overall availability rate of nearly 80%. Only 68% (280) of articles could be retrieved electronically via the link resolver. The biggest barriers to access in both instances were lack of holdings and incomplete coverage. The most common problem encountered when retrieving articles via the link resolver was incomplete or inaccurate metadata. Conclusion: An availability study is a useful tool for measuring the quality of electronic access provided by a library and identifying and quantifying barriers to access. PMID:22025906

  18. An availability study of electronic articles in an academic health sciences library.

    PubMed

    Crum, Janet A

    2011-10-01

    The purposes of this study were: to determine the number of articles requested by library users that could be retrieved from the library's collection using the library catalog and link resolver, in other words, the availability rate; and to identify the nature and frequency of problems encountered in this process, so that the problems could be addressed and access to full-text articles could be improved. A sample of 414 requested articles was identified via link resolver log files. Library staff attempted to retrieve these articles using the library catalog and link resolver and documented access problems. Staff were able to retrieve electronic full text for 310 articles using the catalog. An additional 21 articles were available in print, for an overall availability rate of nearly 80%. Only 68% (280) of articles could be retrieved electronically via the link resolver. The biggest barriers to access in both instances were lack of holdings and incomplete coverage. The most common problem encountered when retrieving articles via the link resolver was incomplete or inaccurate metadata. An availability study is a useful tool for measuring the quality of electronic access provided by a library and identifying and quantifying barriers to access.

  19. The Learning Outcomes of Mentoring Library Science Students in Virtual World Reference: A Case Study

    ERIC Educational Resources Information Center

    Purpur, Geraldine; Morris, Jon Levi

    2015-01-01

    This article reports on the cognitive and affective development of students being mentored in virtual reference interview skills by professional librarians. The authors present a case study which examines the impact on student learning resulting from librarian mentor participation and collaboration with students on a course assignment. This study…

  20. Colonel Mustard in the Library with the Knife...Experiencing Virtual Teaming.

    ERIC Educational Resources Information Center

    Roebuck, Deborah Britt

    Virtual teaming has come to stay in the fast developing world of communication as it brings more value to customers, saves costs, accelerates competence, and leverages organizational learning. Therefore, students need to be educated about this new type of team and the tools that are available to facilitate communication and to enhance…

  1. The Learning Outcomes of Mentoring Library Science Students in Virtual World Reference: A Case Study

    ERIC Educational Resources Information Center

    Purpur, Geraldine; Morris, Jon Levi

    2015-01-01

    This article reports on the cognitive and affective development of students being mentored in virtual reference interview skills by professional librarians. The authors present a case study which examines the impact on student learning resulting from librarian mentor participation and collaboration with students on a course assignment. This study…

  2. Academic Library Consortia in Transition.

    ERIC Educational Resources Information Center

    Alberico, Ralph

    2002-01-01

    Using the example of the Virtual Library of Virginia, describes how library consortia are in a state of transformation as technology enables the development of virtual libraries while expanding opportunities for sharing printed works. (EV)

  3. Academic Library Consortia in Transition.

    ERIC Educational Resources Information Center

    Alberico, Ralph

    2002-01-01

    Using the example of the Virtual Library of Virginia, describes how library consortia are in a state of transformation as technology enables the development of virtual libraries while expanding opportunities for sharing printed works. (EV)

  4. Partnering on Virtual Reference Using QuestionPoint: Guidelines for Collaboration between Academic Libraries in Australia/New Zealand and the US

    ERIC Educational Resources Information Center

    Truelson, Judith A.

    2004-01-01

    This paper presents guidelines for establishing a QuestionPoint collaborative virtual reference partnership between academic libraries in Australia/New Zealand and the US. These guidelines reflect the practices of the state-of-the-art collaborative QuestionPoint partnership, "AskASERL" as well as the unofficial standards and guidelines…

  5. Virtual enterprise model for the electronic components business in the Nuclear Weapons Complex

    SciTech Connect

    Ferguson, T.J.; Long, K.S.; Sayre, J.A.; Hull, A.L.; Carey, D.A.; Sim, J.R.; Smith, M.G.

    1994-08-01

    The electronic components business within the Nuclear Weapons Complex spans organizational and Department of Energy contractor boundaries. An assessment of the current processes indicates a need for fundamentally changing the way electronic components are developed, procured, and manufactured. A model is provided based on a virtual enterprise that recognizes distinctive competencies within the Nuclear Weapons Complex and at the vendors. The model incorporates changes that reduce component delivery cycle time and improve cost effectiveness while delivering components of the appropriate quality.

  6. Virtual experiments in electronics: beyond logistics, budgets, and the art of the possible

    NASA Astrophysics Data System (ADS)

    Chapman, Brian

    1999-09-01

    It is common and correct to suppose that computers support flexible delivery of educational resources by offering virtual experiments that replicate and substitute for experiments traditionally offered in conventional teaching laboratories. However, traditional methods are limited by logistics, costs, and what is physically possible to accomplish on a laboratory bench. Virtual experiments allow experimental approaches to teaching and learning to transcend these limits. This paper analyses recent and current developments in educational software for 1st- year physics, 2nd-year electronics engineering and 3rd-year communication engineering, based on three criteria: (1)Is the virtual experiment possible in a real laboratory? (2)How direct is the link between the experimental manipulation and the reinforcement of theoretical learning? (3) What impact might the virtual experiment have on the learner's acquisition of practical measurement skills? Virtual experiments allow more flexibility in the directness of the link between experimental manipulation and the theoretical message. However, increasing the directness of this link may reduce or even abolish the measurement processes associated with traditional experiments. Virtual experiments thus pose educational challenges: (a) expanding the design of experimentally based curricula beyond traditional boundaries and (b) ensuring that the learner acquires sufficient experience in making practical measurements.

  7. Library use and information-seeking behavior of veterinary medical students revisited in the electronic environment.

    PubMed Central

    Pelzer, N L; Wiese, W H; Leysen, J M

    1998-01-01

    Veterinary medical students at Iowa State University were surveyed in January of 1997 to determine their general use of the Veterinary Medical Library and how they sought information in an electronic environment. Comparisons were made between this study and one conducted a decade ago to determine the effect of the growth in electronic resources on student library use and information-seeking behavior. The basic patterns of student activities in the library, resources used to find current information, and resources anticipated for future education needs remained unchanged. The 1997 students used the library most frequently for photocopying, office supplies, and studying coursework; they preferred textbooks and handouts as sources of current information. However, when these students went beyond textbooks and handouts to seek current information, a major shift was seen from the use of print indexes and abstracts in 1987 towards the use of computerized indexes and other electronic resources in 1997. Almost 60% of the students reported using the Internet for locating current information. Overall use of electronic materials was highest among a group of students receiving the problem-based learning method of instruction. Most of the students surveyed in 1997 indicated that electronic resources would have some degree of importance to them for future education needs. The electronic environment has provided new opportunities for information professionals to help prepare future veterinarians, some of whom will be practicing in remote geographical locations, to access the wealth of information and services available on the Internet and Web. PMID:9681170

  8. Preparing to Teach in Cyberspace: User Education in Real and Virtual Libraries.

    ERIC Educational Resources Information Center

    Byron, Suzanne

    1995-01-01

    Discussion of librarians' training for teaching user education focuses on experiments at the University of North Texas in providing resources and empowering education for librarians and staff members who teach. The use of computer-based education principles and Ranganathan's laws of library science are explained. (Author/LRW)

  9. Virtual Libraries: Interactive Support Software and an Application in Chaotic Models.

    ERIC Educational Resources Information Center

    Katsirikou, Anthi; Skiadas, Christos; Apostolou, Apostolos; Rompogiannakis, Giannis

    This paper begins with a discussion of the characteristics and the singularity of chaotic systems, including dynamic systems theory, chaotic orbit, fractals, chaotic attractors, and characteristics of chaotic systems. The second section addresses the digital libraries (DL) concept and the appropriateness of chaotic models, including definition and…

  10. The Role of the Access Services Manager in the Virtual Library

    ERIC Educational Resources Information Center

    Jetton, Lora Lennertz; Bailey, Alberta S.

    2010-01-01

    This article updates a previous article published in 1992 that described the role of the access services manager in policy formation. Since that time, the access services department and mission has matured and evolved to a prominent position within the library organization. Technological changes and innovation in the marketplace of wired and…

  11. Virtual Reference Services.

    ERIC Educational Resources Information Center

    Brewer, Sally

    2003-01-01

    As the need to access information increases, school librarians must create virtual libraries. Linked to reliable reference resources, the virtual library extends the physical collection and library hours and lets students learn to use Web-based resources in a protected learning environment. The growing number of virtual schools increases the need…

  12. Virtual Reference Services.

    ERIC Educational Resources Information Center

    Brewer, Sally

    2003-01-01

    As the need to access information increases, school librarians must create virtual libraries. Linked to reliable reference resources, the virtual library extends the physical collection and library hours and lets students learn to use Web-based resources in a protected learning environment. The growing number of virtual schools increases the need…

  13. Integrated virtual factory and logistics for electronics industry

    NASA Astrophysics Data System (ADS)

    Wang, Haibin; Mueller-Wittig, Wolfgang; Jegathese, Reginald; Song, Meehae; Quick, Jochen; Zhong, Yongmin

    2003-04-01

    Funded by the Singapore National Science and Technology Board (NSTB), CAMTech is collaborating with a Singaporean research institute and two industry partners with the objective to improve electronics assembly processes. The goal of this project is to visualize the behavior of an electronics assembly industry by simulating, visualizing the discrete events of the entire manufacturing processes and observing the flow of materials, size of buffers, and line balancing. The traditional scenario -- from the customer placing order for a product to delivery -- goes through various phases including manufacturing the product. Several major electronics manufacturing stages can be addressed: fabrication, assembly, testing, and packing. Each of these stages accounts for set up, process, failure, and wait time periods. A delay in one process will accumulate over to the future delays. To simulate the discrete events a general-purpose simulation system has been employed. For modeling and visualization CASUS (Computer Animation of Simulation Traces) system has been used developed by Fraunhofer Institute for Computer Graphics (Fraunhofer-IGD). This work focuses on the prototype interface between simulation trace file and CASUS animation scripts. The final system provides a 3-D visualization of electronics assembly processes based on event-oriented simulator data.

  14. The E-RBR: Confirming the Technology and Exploring the Law of "Electronic Reserves." Two Generations of the Digital Library System at the SDSU Library.

    ERIC Educational Resources Information Center

    Goodram, Richard J.

    1996-01-01

    The Electronic Reserve Book Room Project (E-RBR) was a two-stage project with three major objectives: (1) to provide San Diego State University Library (California) with experience in applying imaging technology; (2) to provide a model for the resolution of the copyright problems inherent in the Library's application of these technologies; and (3)…

  15. Collection-Based Persistent Digital Archives-Part 2 [and] MyLibrary: Personalized Electronic Services in the Cornell University Library [and] Creating Accessible Digital Imagery.

    ERIC Educational Resources Information Center

    Moore, Reagan; Baru, Chaitan; Rajasekar, Arcot; Ludaescher, Bertram; Marciano, Richard; Wan, Michael; Schroeder, Wayne; Gupta, Amarnath; [and] Cohen, Suzanne; Fereira, John; Horne, Angela; Kibbee, Bob; Mistlebauer, Holly; Smith, Adam; [and] Birdsey, Clare L.

    2000-01-01

    Includes three articles that discuss: (1) the creation of a persistent digital archive email collection, including technical issues; (2) a project at Cornell University that provides library users with personalized electronic library services; and (3) the digitization of a photographic collection in the United Kingdom for preservation purposes.…

  16. Ranking targets in structure-based virtual screening of three-dimensional protein libraries: methods and problems.

    PubMed

    Kellenberger, Esther; Foata, Nicolas; Rognan, Didier

    2008-05-01

    Structure-based virtual screening is a promising tool to identify putative targets for a specific ligand. Instead of docking multiple ligands into a single protein cavity, a single ligand is docked in a collection of binding sites. In inverse screening, hits are in fact targets which have been prioritized within the pool of best ranked proteins. The target rate depends on specificity and promiscuity in protein-ligand interactions and, to a considerable extent, on the effectiveness of the scoring function, which still is the Achilles' heel of molecular docking. In the present retrospective study, virtual screening of the sc-PDB target library by GOLD docking was carried out for four compounds (biotin, 4-hydroxy-tamoxifen, 6-hydroxy-1,6-dihydropurine ribonucleoside, and methotrexate) of known sc-PDB targets and, several ranking protocols based on GOLD fitness score and topological molecular interaction fingerprint (IFP) comparison were evaluated. For the four investigated ligands, the fusion of GOLD fitness and two IFP scores allowed the recovery of most targets, including the rare proteins which are not readily suitable for statistical analysis, while significantly filtering out most false positive entries. The current survey suggests that selecting a small number of targets (<20) for experimental evaluation is achievable with a pure structure-based approach.

  17. Discovery of nonsteroidal 17beta-hydroxysteroid dehydrogenase 1 inhibitors by pharmacophore-based screening of virtual compound libraries.

    PubMed

    Schuster, Daniela; Nashev, Lyubomir G; Kirchmair, Johannes; Laggner, Christian; Wolber, Gerhard; Langer, Thierry; Odermatt, Alex

    2008-07-24

    17Beta-hydroxysteroid dehydrogenase type 1 (17beta-HSD1) plays a pivotal role in the local synthesis of the most potent estrogen estradiol. Its expression is a prognostic marker for the outcome of patients with breast cancer and inhibition of 17beta-HSD1 is currently under consideration for breast cancer prevention and treatment. We aimed to identify nonsteroidal 17beta-HSD1 inhibitor scaffolds by virtual screening with pharmacophore models built from crystal structures containing steroidal compounds. The most promising model was validated by comparing predicted and experimentally determined inhibitory activities of several flavonoids. Subsequently, a virtual library of nonsteroidal compounds was screened against the 3D pharmacophore. Analysis of 14 selected compounds yielded four that inhibited the activity of human 17beta-HSD1 (IC 50 below 50 microM). Specificity assessment of identified 17beta-HSD1 inhibitors emphasized the importance of including related short-chain dehydrogenase/reductase (SDR) members to analyze off-target effects. Compound 29 displayed at least 10-fold selectivity over the related SDR enzymes tested.

  18. Human recombinant beta-secretase immobilized enzyme reactor for fast hits' selection and characterization from a virtual screening library.

    PubMed

    De Simone, Angela; Mancini, Francesca; Cosconati, Sandro; Marinelli, Luciana; La Pietra, Valeria; Novellino, Ettore; Andrisano, Vincenza

    2013-01-25

    In the present work, a human recombinant BACE1 immobilized enzyme reactor (hrBACE1-IMER) has been applied for the sensitive fast screening of 38 compounds selected through a virtual screening approach. HrBACE1-IMER was inserted into a liquid chromatograph coupled with a fluorescent detector. A fluorogenic peptide substrate (M-2420), containing the β-secretase site of the Swedish mutation of APP, was injected and cleaved in the on-line HPLC-hrBACE1-IMER system, giving rise to the fluorescent product. The compounds of the library were tested for their ability to inhibit BACE1 in the immobilized format and to reduce the area related to the chromatographic peak of the fluorescent enzymatic product. The results were validated in solution by using two different FRET methods. Due to the efficient virtual screening methodology, more than fifty percent of the selected compounds showed a measurable inhibitory activity. One of the most active compound (a bis-indanone derivative) was characterized in terms of IC(50) and K(i) determination on the hrBACE1-IMER. Thus, the hrBACE1-IMER has been confirmed as a valid tool for the throughput screening of different chemical entities with potency lower than 30μM for the fast hits' selection and for mode of action determination.

  19. How to benchmark methods for structure-based virtual screening of large compound libraries.

    PubMed

    Christofferson, Andrew J; Huang, Niu

    2012-01-01

    Structure-based virtual screening is a useful computational technique for ligand discovery. To systematically evaluate different docking approaches, it is important to have a consistent benchmarking protocol that is both relevant and unbiased. Here, we describe the designing of a benchmarking data set for docking screen assessment, a standard docking screening process, and the analysis and presentation of the enrichment of annotated ligands among a background decoy database.

  20. Copper(I)-induced amplification of a [2]catenane in a virtual dynamic library of macrocyclic alkenes.

    PubMed

    Berrocal, José Augusto; Nieuwenhuizen, Marko M L; Mandolini, Luigi; Meijer, E W; Di Stefano, Stefano

    2014-08-28

    Olefin cross-metathesis of diluted dichloromethane solutions (≤0.15 M) of the 28-membered macrocyclic alkene C1, featuring a 1,10-phenanthroline moiety in the backbone, as well as of catenand 1, composed of two identical interlocked C1 units, generates families of noninterlocked oligomers Ci. The composition of the libraries is strongly dependent on the monomer concentration, but independent of whether C1 or 1 is used as feedstock, as expected for truly equilibrated systems. Accordingly, the limiting value 0.022 M approached by the equilibrium concentration of C1 when the total monomer concentration approaches the critical value, as predicted by the Jacobson-Stockmayer theory, provides a reliable estimate of the thermodynamically effective molarity. Catenand 1 behaves as a virtual component of the dynamic libraries, in that there is no detectable trace of its presence in the equilibrated mixtures, but becomes the major component - in the form of its copper(I) complex - when olefin cross-metathesis is carried out in the presence of a copper(I) salt.

  1. Decoding Split and Pool Combinatorial Libraries with Electron Transfer Dissociation Tandem Mass Spectrometry

    PubMed Central

    Sarkar, Mohosin; Pascal, Bruce D.; Steckler, Caitlin; Aquino, Claudio; Micalizio, Glenn C.; Kodadek, Thomas; Chalmers, Michael J.

    2015-01-01

    Screening of bead-based split and pool combinatorial chemistry libraries is a powerful approach to aid the discovery of new chemical compounds able to interact with, and modulate the activities of, protein targets of interest. Split and pool synthesis provides for large and well diversified chemical libraries, in this case comprised of oligomers generated from a well-defined starting set. At the end of the synthesis, each bead in the library displays many copies of a unique oligomer sequence. Because the sequence of the oligomer is not known at the time of screening, methods for decoding of the sequence of each screening “hit” are essential. Here we describe an electron transfer dissociation (ETD) based tandem mass spectrometry approach for the decoding of mass-encoded split and pool libraries. We demonstrate that the newly described “chiral oligomers of pentenoic amides (COPAs)” yield non-sequence-specific product ions upon collisional activated dissociation; however, complete sequence information can be obtained with ETD. To aid in the decoding of libraries from MS and MS/MS data, we have incorporated 79Br/81Br isotope “tags” to differentiate N- and C-terminal product ions. In addition, we have created “Hit-Find,” a software program that allows users to generate libraries in silico. The user can then search all possible members of the chemical library for those that fall within a user-defined mass error. PMID:23636859

  2. OptiDock: virtual HTS of combinatorial libraries by efficient sampling of binding modes in product space.

    PubMed

    Sprous, Dennis G; Lowis, David R; Leonard, Joseph M; Heritage, Trevor; Burkett, Steven N; Baker, David S; Clark, Robert D

    2004-01-01

    Products from combinatorial libraries generally share a common core structure that can be exploited to improve the efficiency of virtual high-throughput screening (vHTS). In general, it is more efficient to find a method that scales with the total number of reagents (Sigma growth) rather with the number of products (Pi growth). The OptiDock methodology described herein entails selecting a diverse but representative subset of compounds that span the structural space encompassed by the full library. These compounds are docked individually using the FlexX program (Rarey, M.; Kramer, B.; Lengauer, T.; Klebe, G. J. Mol. Biol. 1995, 251, 470-489) to define distinct docking modes in terms of reference placements for combinatorial core atoms. Thereafter, substituents in R-cores (consisting of the core structure substituted at a single variation site) are docked, keeping the core atoms fixed at the coordinates dictated by each reference placement. Interaction energies are calculated for each docked R-core with respect to the target protein, and energies for whole compounds are calculated by finding the reference core placement for which the sum of corresponding R-core energies is most negative. The use of diverse whole compounds to define binding modes is a key advantage of the protocol over other combinatorial docking programs. As a result, OptiDock returns better-scoring conformers than does serially applied FlexX. OptiDock is also better able to find a viable docked pose for each library member than are other combinatorial approaches.

  3. Electronic Theses and Dissertations. Transforming Libraries Number 7.

    ERIC Educational Resources Information Center

    Soete, George J.

    1998-01-01

    This report summarizes the current state of electronic theses and dissertations (ETDs). The introduction covers: an orientation to ETDs; the current situation; benefits of ETDs; key issues, including readiness, publication potential, intellectual property, orientation and training, standards, costs, access, archiving/preservation, and…

  4. Brave New World or "Plus Ca Change"?: Electronic Journals and the Academic Library

    ERIC Educational Resources Information Center

    Burrows, Toby

    2006-01-01

    The impact that electronic information technologies have had on scholarly communications and university libraries is assessed. Early predictions that the dominance of commercial publishers would decline and journal prices would fall have not been realised. The development of institutional repositories have had limited success in making the…

  5. Hey, Look Who Took This Out!--Privacy in the Electronic Library.

    ERIC Educational Resources Information Center

    Merry, Lois K.

    1996-01-01

    To protect their copyrights, electronic publishers and document delivery providers track usage and personal information which threatens library users' privacy and rights to intellectual freedom and access to information. Suggests using data encryption software as a solution. Recommends librarians advocate a competitive marketplace by working for…

  6. The Victorian Women Writers Project: The Library as a Creator and Publisher of Electronic Texts.

    ERIC Educational Resources Information Center

    Willett, Perry

    1996-01-01

    Describes the Victorian Women Writers Project, a full-text poetry database created and published on the World Wide Web by Indiana University Libraries. Electronic formats such as graphical, character-based, and proprietary files are discussed, along with standards for formatting, including ASCII, HTML, and Text Encoding Initiatives. Decisions must…

  7. The Electronic Library and the Online Classroom: A Technical, Legal, Ethical, and Moral Perspective.

    ERIC Educational Resources Information Center

    Latimore, Ritchie R.

    This paper addresses online classroom and electronic library issues which include the myriad of technical difficulties encountered, along with physical and intellectual property rights. It also makes a statistical comparison of two proportions of Internet access between city and rural schools. An inescapable time lag between the introduction of…

  8. The Unlimited Potential of the Electronic Library (Except Where Prohibited by the Copyright Law).

    ERIC Educational Resources Information Center

    Schmidt, Steven; Lewis, David

    This paper describes the creation of a new library facility for Indiana University-Purdue University at Indianapolis, one designed ready to accommodate an infrastructure that would support the new technologies of the electronic information environment. Wiring and fiber-optic schemes are outlined briefly. The document is formatted as a script for…

  9. Implementation of an Electronic Resource Assessment System in an Academic Library

    ERIC Educational Resources Information Center

    Xu, Fei

    2010-01-01

    Purpose: The purpose of this paper is to provide a library with useful information about selection criteria for an electronic resource assessment system and practical assistance on how to implement efficiently such a system. Design/methodology/approach: The paper is based on literature review, desk research, and implementation experience.…

  10. Why Microfilm Research-Library Collections When Electronic Data Bases Could Be Used?

    ERIC Educational Resources Information Center

    Smith, Eldred

    1991-01-01

    Discusses the national program for preservation microfilming in research libraries and suggests that microfilm is not the appropriate medium to be used. Recommendations for the electronic storage of materials on computerized databases are made; disadvantages of microfilm are described; interlibrary loan problems are discussed; and effects on…

  11. Making the Transition from Print to Electronic Serial Collections: A New Model for Academic Chemistry Libraries?

    ERIC Educational Resources Information Center

    Chrzastowski, Tina E.

    2003-01-01

    Proposes a new model for an academic chemistry library based on experiences at the University of Illinois at Urbana-Champaign in which primary access to journals is electronic and print journals are archived unbound in a remote storage facility following local access for one year. Discusses results of a feasibility study. (Author/LRW)

  12. Program: A Record of the First 40 Years of Electronic Library and Information Systems

    ERIC Educational Resources Information Center

    Tedd, Lucy A.

    2006-01-01

    Purpose: To provide a broad overview of the history of the journal Program: electronic library and information systems and its contents over its first 40 years. Design/methodology/approach: Analysis of content from the original published material, as well as from abstracting and indexing publications and from minutes of Editorial Board meetings.…

  13. Hey, Look Who Took This Out!--Privacy in the Electronic Library.

    ERIC Educational Resources Information Center

    Merry, Lois K.

    1996-01-01

    To protect their copyrights, electronic publishers and document delivery providers track usage and personal information which threatens library users' privacy and rights to intellectual freedom and access to information. Suggests using data encryption software as a solution. Recommends librarians advocate a competitive marketplace by working for…

  14. An Electronic Library-Based Learning Environment for Supporting Web-Based Problem-Solving Activities

    ERIC Educational Resources Information Center

    Tsai, Pei-Shan; Hwang, Gwo-Jen; Tsai, Chin-Chung; Hung, Chun-Ming; Huang, Iwen

    2012-01-01

    This study aims to develop an electronic library-based learning environment to support teachers in developing web-based problem-solving activities and analyzing the online problem-solving behaviors of students. Two experiments were performed in this study. In study 1, an experiment on 103 elementary and high school teachers (the learning activity…

  15. Free Scholarly Electronic Journals: What Access Do College and University Libraries Provide?

    ERIC Educational Resources Information Center

    Fosmire, Michael; Young, Elizabeth

    2000-01-01

    The 25 most popular free scholarly electronic journal titles, determined by number of holding institutions on OCLC, were searched on a random sample of library World Wide Web sites and catalogs to provide a separate gauge for access levels provided by institutions. Access levels were fairly low and decreased dramatically with size of the…

  16. Evaluating Open Source Software for Use in Library Initiatives: A Case Study Involving Electronic Publishing

    ERIC Educational Resources Information Center

    Samuels, Ruth Gallegos; Griffy, Henry

    2012-01-01

    This article discusses best practices for evaluating open source software for use in library projects, based on the authors' experience evaluating electronic publishing solutions. First, it presents a brief review of the literature, emphasizing the need to evaluate open source solutions carefully in order to minimize Total Cost of Ownership. Next,…

  17. Oklahoma Library Technology Network (OLTN) Electronic Resources for Elementary Age Children.

    ERIC Educational Resources Information Center

    Fox, Carol, Comp.

    This document describes Oklahoma Library Technology Network electronic resources for elementary age children. The first section provides a history of Oklahoma statewide shared databases. Oklahoma statewide information database contacts are listed in the second section. The third section presents information on InfoTrac Kid's Edition Online…

  18. Digital Data Preservation and Curation: A Collaboration Among Libraries, Publishers, and the Virtual Observatory

    NASA Astrophysics Data System (ADS)

    Hanisch, R. J.; Steffen, J.; Choudhury, S.; Dilauro, T.; Szalay, A.; Vishniac, E.; Ehling, T.; Milkey, R.; Plante, R.

    2007-10-01

    Astronomers are producing and analyzing data at ever more prodigious rates. NASA's Great Observatories, ground-based national observatories, and major survey projects have archive and data distribution systems in place to manage their standard data products, and these are now interlinked through the protocols and metadata standards agreed upon in the Virtual Observatory. However, the digital data associated with peer-reviewed publications is only rarely archived. Most often, astronomers publish graphical representations of their data but not the data themselves. Other astronomers cannot readily inspect the data to either confirm the interpretation presented in a paper or extend the analysis. Highly processed data sets reside on departmental servers and the personal computers of astronomers, and may or may not be available a few years hence. We are investigating ways to preserve and curate the digital data associated with peer-reviewed journals in astronomy. The technology and standards of the VO provide one component of the necessary technology. A variety of underlying systems can be used to physically host a data repository, and indeed this repository need not be centralized. The repository, however, must be managed and data must be documented through high quality, curated metadata. Multiple access portals must be available: the original journal, the host data center, the Virtual Observatory, or any number of topically-oriented data services utilizing VO-standard access mechanisms.

  19. The Organization of Knowledge Spaces for a Virtual Learning Environment Supported by a Digital Library

    NASA Astrophysics Data System (ADS)

    Smith, Terence R.; Agapova, Olga; Freeston, Michael; Ushakov, Alex

    This paper represents the combined work of the whole of the ADEPT Knowledge Organization Team. Other members are: Olha Buchel, Jim Frew, Linda Hill, Richard Mayer, Jian Qin, Laura Smart, and Tim Tierney. The Alexandria Digital Library Project is developing a concept-based learning environment for the sciences. In this paper, we briefly discuss: the rationale for the approach; the structure of the concept model and correlative relationships between concepts; the components and associated services of the concept-based learning environment; and planned and potential applications of the learning environment.

  20. Do electronic mail discussion lists act as virtual colleagues?

    PubMed Central

    Worth, E. R.; Patrick, T. B.

    1997-01-01

    Anesthesiology Discussion Group (ADG), an electronic mail (email) discussion list, has previously been shown to be a clinically oriented, cost-effective form of telemedicine. ADG is composed of an international collection of anesthesia providers. Discussions with colleagues are generally informal in nature and are examples of types of information-seeking behavior which frequently occur in hallways or lounges of a hospital or clinic. Information-seeking occurs when a health care provider searches for information which will be used to solve or satisfy a patient's problem or need. We surveyed practitioners who had previously submitted non-rhetorical, clinical questions to the group. After analysis of the questionnaire results, we conclude that ADG is a valuable resource used for information-seeking and is a clinically effective form of telemedicine. Many of the respondents indicated that they used ADG to obtain second opinions from the collective expertise of group members. Respondents also indicated that they were generally satisfied with the quality of responses and would not hesitate to use ADG for future clinical questions. PMID:9357641

  1. Existence of a virtual cathode close to a strongly electron emissive wall in low density plasmas

    NASA Astrophysics Data System (ADS)

    Tierno, S. P.; Donoso, J. M.; Domenech-Garret, J. L.; Conde, L.

    2016-01-01

    The interaction between an electron emissive wall, electrically biased in a plasma, is revisited through a simple fluid model. We search for realistic conditions of the existence of a non-monotonic plasma potential profile with a virtual cathode as it is observed in several experiments. We mainly focus our attention on thermionic emission related to the operation of emissive probes for plasma diagnostics, although most conclusions also apply to other electron emission processes. An extended Bohm criterion is derived involving the ratio between the two different electron densities at the potential minimum and at the background plasma. The model allows a phase-diagram analysis, which confirms the existence of the non-monotonic potential profiles with a virtual cathode. This analysis shows that the formation of the potential well critically depends on the emitted electron current and on the velocity at the sheath edge of cold ions flowing from the bulk plasma. As a consequence, a threshold value of the governing parameter is required, in accordance to the physical nature of the electron emission process. The latter is a threshold wall temperature in the case of thermionic electrons. Experimental evidence supports our numerical calculations of this threshold temperature. Besides this, the potential well becomes deeper with increasing electron emission, retaining a fraction of the released current which limits the extent of the bulk plasma perturbation. This noninvasive property would explain the reliable measurements of plasma potential by using the floating potential method of emissive probes operating in the so-called strong emission regime.

  2. Existence of a virtual cathode close to a strongly electron emissive wall in low density plasmas

    SciTech Connect

    Tierno, S. P. Donoso, J. M.; Domenech-Garret, J. L.; Conde, L.

    2016-01-15

    The interaction between an electron emissive wall, electrically biased in a plasma, is revisited through a simple fluid model. We search for realistic conditions of the existence of a non-monotonic plasma potential profile with a virtual cathode as it is observed in several experiments. We mainly focus our attention on thermionic emission related to the operation of emissive probes for plasma diagnostics, although most conclusions also apply to other electron emission processes. An extended Bohm criterion is derived involving the ratio between the two different electron densities at the potential minimum and at the background plasma. The model allows a phase-diagram analysis, which confirms the existence of the non-monotonic potential profiles with a virtual cathode. This analysis shows that the formation of the potential well critically depends on the emitted electron current and on the velocity at the sheath edge of cold ions flowing from the bulk plasma. As a consequence, a threshold value of the governing parameter is required, in accordance to the physical nature of the electron emission process. The latter is a threshold wall temperature in the case of thermionic electrons. Experimental evidence supports our numerical calculations of this threshold temperature. Besides this, the potential well becomes deeper with increasing electron emission, retaining a fraction of the released current which limits the extent of the bulk plasma perturbation. This noninvasive property would explain the reliable measurements of plasma potential by using the floating potential method of emissive probes operating in the so-called strong emission regime.

  3. Combinatorial support vector machines approach for virtual screening of selective multi-target serotonin reuptake inhibitors from large compound libraries.

    PubMed

    Shi, Z; Ma, X H; Qin, C; Jia, J; Jiang, Y Y; Tan, C Y; Chen, Y Z

    2012-02-01

    Selective multi-target serotonin reuptake inhibitors enhance antidepressant efficacy. Their discovery can be facilitated by multiple methods, including in silico ones. In this study, we developed and tested an in silico method, combinatorial support vector machines (COMBI-SVMs), for virtual screening (VS) multi-target serotonin reuptake inhibitors of seven target pairs (serotonin transporter paired with noradrenaline transporter, H(3) receptor, 5-HT(1A) receptor, 5-HT(1B) receptor, 5-HT(2C) receptor, melanocortin 4 receptor and neurokinin 1 receptor respectively) from large compound libraries. COMBI-SVMs trained with 917-1951 individual target inhibitors correctly identified 22-83.3% (majority >31.1%) of the 6-216 dual inhibitors collected from literature as independent testing sets. COMBI-SVMs showed moderate to good target selectivity in misclassifying as dual inhibitors 2.2-29.8% (majority <15.4%) of the individual target inhibitors of the same target pair and 0.58-7.1% of the other 6 targets outside the target pair. COMBI-SVMs showed low dual inhibitor false hit rates (0.006-0.056%, 0.042-0.21%, 0.2-4%) in screening 17 million PubChem compounds, 168,000 MDDR compounds, and 7-8181 MDDR compounds similar to the dual inhibitors. Compared with similarity searching, k-NN and PNN methods, COMBI-SVM produced comparable dual inhibitor yields, similar target selectivity, and lower false hit rate in screening 168,000 MDDR compounds. The annotated classes of many COMBI-SVMs identified MDDR virtual hits correlate with the reported effects of their predicted targets. COMBI-SVM is potentially useful for searching selective multi-target agents without explicit knowledge of these agents.

  4. Characterization of the phantom material virtual water in high-energy photon and electron beams.

    PubMed

    McEwen, M R; Niven, D

    2006-04-01

    The material Virtual Water has been characterized in photon and electron beams. Range-scaling factors and fluence correction factors were obtained, the latter with an uncertainty of around 0.2%. This level of uncertainty means that it may be possible to perform dosimetry in a solid phantom with an accuracy approaching that of measurements in water. Two formulations of Virtual Water were investigated with nominally the same elemental composition but differing densities. For photon beams neither formulation showed exact water equivalence-the water/Virtual Water dose ratio varied with the depth of measurement with a difference of over 1% at 10 cm depth. However, by using a density (range) scaling factor very good agreement (<0.2%) between water and Virtual Water at all depths was obtained. In the case of electron beams a range-scaling factor was also required to match the shapes of the depth dose curves in water and Virtual Water. However, there remained a difference in the measured fluence in the two phantoms after this scaling factor had been applied. For measurements around the peak of the depth-dose curve and the reference depth this difference showed some small energy dependence but was in the range 0.1%-0.4%. Perturbation measurements have indicated that small slabs of material upstream of a detector have a small (<0.1% effect) on the chamber reading but material behind the detector can have a larger effect. This has consequences for the design of experiments and in the comparison of measurements and Monte Carlo-derived values.

  5. An electronic consumer health library: NetWellness.

    PubMed Central

    Guard, R; Haag, D; Kaya, B; Marine, S; Morris, T; Schick, L; Shoemaker, S

    1996-01-01

    NetWellness is a community-based, consumer-defined grant program supporting the delivery of electronic health information to rural residents of southern Ohio and urban and suburban communities in the Greater Cincinnati tri-state region. NetWellness is a collaboratively developed and publicly and privately funded demonstration project. Information is delivered via ISDN, standard dial, dedicated network connections, and the Internet. TriState Online (Greater Cincinnati's Free-Net) and other southern Ohio Free-Nets are key access points in the larger project communities. The other access points are more than forty workstations distributed at public sites throughout the project's primary geographical area. Design strengths and limitations, training initiatives, technical issues, and the project's impact on medical librarianship are examined in this paper. Also discussed are ways of determining community needs and interest, building political alliances, finding and developing funding sources, and overcoming technical obstacles. NetWellness's Internet address is: http:@www.netwellness.org. PMID:8913548

  6. An investigation into the move towards electronic journals: a case study of NHS libraries in Kent, Surrey and Sussex.

    PubMed

    England, Rebecca

    2013-09-01

    Electronic journals are so embedded into practice in academic libraries that it is easy to forget that this is not the case everywhere. In NHS libraries, for example, the staff face a particular set of issues. This article is based on Rebecca England's dissertation on this topic, completed as part of the MSc Econ course in Information and Library studies at Aberystwyth University. Rebecca is E-resources Librarian at the Maidstone and Tunbridge Wells NHS Trust. She investigated the momentum towards electronic journals in NHS libraries in the Kent, Surrey and Sussex region and the potential for a regional purchasing consortium.

  7. Evaluation of large format electron bombarded virtual phase CCDs as ultraviolet imaging detectors

    NASA Technical Reports Server (NTRS)

    Opal, Chet B.; Carruthers, George R.

    1989-01-01

    In conjunction with an external UV-sensitive cathode, an electron-bombarded CCD may be used as a high quantum efficiency/wide dynamic range photon-counting UV detector. Results are presented for the case of a 1024 x 1024, 18-micron square pixel virtual phase CCD used with an electromagnetically focused f/2 Schmidt camera, which yields excellent simgle-photoevent discrimination and counting efficiency. Attention is given to the vacuum-chamber arrangement used to conduct system tests and the CCD electronics and data-acquisition systems employed.

  8. Virtual photon structure functions and the parton content of the electron

    SciTech Connect

    Drees, M. ); Godbole, R.M. )

    1994-09-01

    We point out that in processes involving the parton content of the photon the usual effective photon approximation should be modified. The reason is that the parton content of virtual photons is logarithmically suppressed compared to real photons. We describe this suppression using several simple, physically motivated [ital Ansa]$[ital uml---tze]. Although the parton content of the electron in general no longer factorizes into an electron flux function and a photon structure function, it can still be expressed as a single integral. Numerical examples are given for the [ital e][sup +][ital e][sup [minus

  9. Evaluation of large format electron bombarded virtual phase CCDs as ultraviolet imaging detectors

    NASA Technical Reports Server (NTRS)

    Opal, Chet B.; Carruthers, George R.

    1989-01-01

    In conjunction with an external UV-sensitive cathode, an electron-bombarded CCD may be used as a high quantum efficiency/wide dynamic range photon-counting UV detector. Results are presented for the case of a 1024 x 1024, 18-micron square pixel virtual phase CCD used with an electromagnetically focused f/2 Schmidt camera, which yields excellent simgle-photoevent discrimination and counting efficiency. Attention is given to the vacuum-chamber arrangement used to conduct system tests and the CCD electronics and data-acquisition systems employed.

  10. Evaluation and optimization of virtual screening workflows with DEKOIS 2.0--a public library of challenging docking benchmark sets.

    PubMed

    Bauer, Matthias R; Ibrahim, Tamer M; Vogel, Simon M; Boeckler, Frank M

    2013-06-24

    The application of molecular benchmarking sets helps to assess the actual performance of virtual screening (VS) workflows. To improve the efficiency of structure-based VS approaches, the selection and optimization of various parameters can be guided by benchmarking. With the DEKOIS 2.0 library, we aim to further extend and complement the collection of publicly available decoy sets. Based on BindingDB bioactivity data, we provide 81 new and structurally diverse benchmark sets for a wide variety of different target classes. To ensure a meaningful selection of ligands, we address several issues that can be found in bioactivity data. We have improved our previously introduced DEKOIS methodology with enhanced physicochemical matching, now including the consideration of molecular charges, as well as a more sophisticated elimination of latent actives in the decoy set (LADS). We evaluate the docking performance of Glide, GOLD, and AutoDock Vina with our data sets and highlight existing challenges for VS tools. All DEKOIS 2.0 benchmark sets will be made accessible at http://www.dekois.com.

  11. Creating a State-Wide Virtual Health Library: The Michigan Experience.

    ERIC Educational Resources Information Center

    Brenneise, Harvey

    The AccessMichigan Electronic Community Health Information Initiative (AMECHII) is a response to a recommendation of the Michigan Information Technology Commission Report recommending improved access to high-quality health care information for all Michigan stakeholders. This project is multi-type, including public, general academic, academic…

  12. [Application of the technique of analytical structure of project for the sub-project of websites catalog of the Virtual Health Library-Nursing].

    PubMed

    dos, Santos Luís Augusto; Marin, Heimar de Fátima; Marques, Isaac Rosa; Cunha, Isabel Cristina Kowal Olm

    2007-01-01

    This work intents, in a didactic form, to explain the benefits of use of a technique of project management, named Work Breakdown Structure: a graphical tool to identify the main results to be developed in a project. The real examples are applied to a sub-project of the Virtual Library in Health in Nursing (BVS-Enfermagem) to development of the Sites Catalogs. The benefits of graphical visualization for a major agreement between professionals of different expertise are presented.

  13. A first class knowledge service: developing the National electronic Library for Health.

    PubMed

    Turner, Alison; Fraser, Veronica; Muir Gray, J A; Toth, Ben

    2002-09-01

    With the introduction of clinical governance and the move towards evidence-based practice, there is a growing need to provide health professionals and patients, and the public, with high quality information. Developments in the health service have added weight and urgency to this need. The National electronic Library for Health (NeLH) has a key role to play in providing health professionals with a core knowledge base of accredited and evaluated information. The Pilot NeLH was launched in November and this article outlines the progress and achievements made during this time. The NeLH is based around a central website featuring core resources and links to commissioned specialist collections. Over 70 information resources, including bibliographic databases and full text publications, are accessible via the NeLH, which aims to act as a one-stop shop to support evidence-based decision-making. Much work has been undertaken on national procurement and licensing, particularly in partnership with National Health Service (NHS) libraries. Partnerships as a whole are crucial to ensure true seamless access for health professionals. Key partners include NHS libraries, NHS Direct Online and the electronic Library for Social Care. A short glossary is included for those readers less familiar with current health service developments in the UK.

  14. Motion of a virtual cathode in a cylindrical channel with electron beam transport in the "compressed" state

    NASA Astrophysics Data System (ADS)

    Belomyttsev, S. Ya.; Grishkov, A. A.; Kurkan, I. K.; Tsygankov, R. V.

    2014-03-01

    This paper studies the motion of a virtual cathode in a two-section drift tube with the formation and breakup of the "compressed" state of an electron beam. Experimental arrangements to intercept part of the injected current during the voltage pulse and to provide virtual cathode motion toward the collector are proposed. The arrangements were implemented on the SINUS-7 high-current electron accelerator. Theoretical and experimental dependences of the virtual cathode velocity on the injected current and cathode voltage are presented. The experimental data on virtual cathode motion agree with its theoretical model based on analytical solutions of equations assisted by computer simulation with the PIC code KARAT. The results of the work demonstrate the feasibility of controlling the virtual cathode motion which can be used in collective ion acceleration and microwave generation.

  15. National Library Service of the Library of Congress: New Electronic Information Projects. Part Four of a Four-Part Series.

    ERIC Educational Resources Information Center

    McNulty, Tom, Ed.

    1995-01-01

    This final installment of a four-part series on the National Library Service (NLS) examines recently implemented and future projects, with a focus on alternative formats for patrons with disabilities. Discusses LOCIS, the Library of Congress online public access catalog; MARVEL, the Library of Congress gopher; the NLS Web site; and computer disk…

  16. Rethinking Virtual Reference

    ERIC Educational Resources Information Center

    Tenopir, Carol

    2004-01-01

    Virtual reference services seem a natural extension of libraries digital collections and the emphasis on access to the library anytime, anywhere. If patrons use the library from home, it makes sense to provide them with person-to-person online reference. The Library of Congress (LC), OCLC, and several large library systems have developed and…

  17. Antiviral Compounds Discovered by Virtual Screening of Small–Molecule Libraries against Dengue Virus E Protein

    PubMed Central

    Zhou, Zhigang; Khaliq, Mansoora; Suk, Jae-Eun; Patkar, Chinmay; Li, Long; Kuhn, Richard J.; Post, Carol Beth

    2009-01-01

    Infection by the mosquito-borne dengue virus causes dengue fever and the sometimes fatal dengue hemorrhagic fever. The increasing number of dengue infections per year suggests that the virus is becoming more virulent and its transmission is expanding. Nevertheless, no effective treatment for dengue infection currently exists. In a search for antiviral agents effective against dengue virus, we investigated the potential of targeting a structural protein site rather than an enzymatic one. Using this approach, we now report the discovery of a small molecule ligand that inhibits viral growth. Our results also provide the first evidence that the binding site, a pocket located at the hinge between domains 1 and 2 of the envelope protein (E protein) on the virus surface, is a valid target for antiviral therapy. Ligand candidates were identified from libraries of ∼142,000 compounds using a computational high-throughput screening protocol targeting this pocket of the E protein. Cell-based assays were conducted on 23 top-ranked compounds. Among four with good antiviral activity profiles, the compound P02 was found to inhibit viral reproduction at micromolar concentrations. Using saturation transfer difference NMR spectroscopy, we also show that the compound binds virus and competes for binding E protein with the known ligand N-octyl-β-d-glucoside. Together, the results are consistent with an inhibition mechanism against maturation or host-cell entry mediated by ligand binding to the E-protein pocket. P02 is a promising lead compound for future development of an effective treatment against dengue virus and related flaviviruses. PMID:19053243

  18. Online Databases: Virtual Reference Services in a Real World.

    ERIC Educational Resources Information Center

    Tenopir, Carol

    2001-01-01

    Discusses the results of a survey of academic member libraries of the ARL (Association of Research Libraries) that investigated changes in reference services over the last three years and how electronic resources have impacted them. Topics include remote users; email reference; and live virtual reference. (LRW)

  19. Picture This... Developing Standards for Electronic Images at the National Library of Medicine

    PubMed Central

    Masys, Daniel R.

    1990-01-01

    New computer technologies have made it feasible to represent, store, and communicate high resolution biomedical images via electronic means. Traditional two dimensional medical images such as those on printed pages have been supplemented by three dimensional images which can be rendered, rotated, and “dissected” from any point of view. The library of the future will provide electronic access not only to words and numbers, but to pictures, sounds, and other nontextual information. There currently exist few widely-accepted standards for the representation and communication of complex images, yet such standards will be critical to the feasibility and usefulness of digital image collections in the life sciences. The National Library of Medicine is embarked on a project to develop a complete digital volumetric representation of an adult human male and female. This “Visible Human Project” will address the issue of standards for computer representation of biological structure.

  20. Quality markers and use of electronic journals in an academic health sciences library*

    PubMed Central

    Wulff, Judith L.; Nixon, Neal D.

    2004-01-01

    Objectives: Patterns of use of electronic versions of journals supplied by an academic health sciences library were examined to determine whether they differed from patterns of use among corresponding print titles and to relate the applicability of print collection development practices to an electronic environment. Methods: Use data supplied by three major vendors of electronic journals were compared to reshelving data for corresponding print titles, impact factors, and presence on Brandon/Hill Lists. Results: In collections where one-click access from a database record to the full text of articles was possible, electronic use correlated with print use across journal pairs. In both versions, Brandon/Hill titles were used more frequently than non-Brandon/Hill titles, use had modest correlations with journals' impact factors, and clinical use appeared to be higher than research use. Titles that had not been selected for the library's print collections, but which were bundled into publishers' packages, received little use compared to electronic titles also selected in print. Conclusions: Collection development practices based on quality and user needs can be applied with confidence to the electronic environment. Facilitating direct connections between citation databases and the corresponding journal articles regardless of platform or publisher will support scholarship and quality health care. PMID:15243637

  1. A virtual source model of electron contamination of a therapeutic photon beam.

    PubMed

    Sikora, M; Alber, M

    2009-12-21

    The most efficient way of generating particles for Monte Carlo (MC) dose calculation is through a virtual source model (VSM) of the linear accelerator head. We have previously developed a VSM based on three sources: a primary photon source, a secondary photon source and an electron contamination source (Sikora et al 2007). In this work, we present an improvement of the electron contamination source. The VSM of contamination electrons (eVSM) is derived from a full MC simulation of the accelerator head with the BEAMnrc MC system. It comprises a Gaussian source located at the base of the flattening filter. The eVSM models two effects: an energy-dependent source diameter and an angular dependence of the particle fluence. The air scatter of the contamination electrons is approximated by energetic properties of the eVSM so that explicit in-air transport is not required during MC simulation of the dose distributions in the patient. The calculations of electron dose distributions were compared between the eVSM and the full MC simulation. Good agreement was achieved for various rectangular field sizes as well as for complex conformal segment shapes for the contamination electrons of 6 and 15 MV beams. The 3D dose evaluation of the surface dose in a CT-based patient geometry shows high accuracy (2%/2 mm) of the eVSM for both energies. The model has one tunable parameter, the mean energy of the spectrum at the patient surface. High accuracy and efficiency of particle generation make the eVSM a valuable virtual source of contamination electrons for MC treatment planning systems.

  2. Semantic Document Library: A Virtual Research Environment for Documents, Data and Workflows Sharing

    NASA Astrophysics Data System (ADS)

    Kotwani, K.; Liu, Y.; Myers, J.; Futrelle, J.

    2008-12-01

    The Semantic Document Library (SDL) was driven by use cases from the environmental observatory communities and is designed to provide conventional document repository features of uploading, downloading, editing and versioning of documents as well as value adding features of tagging, querying, sharing, annotating, ranking, provenance, social networking and geo-spatial mapping services. It allows users to organize a catalogue of watershed observation data, model output, workflows, as well publications and documents related to the same watershed study through the tagging capability. Users can tag all relevant materials using the same watershed name and find all of them easily later using this tag. The underpinning semantic content repository can store materials from other cyberenvironments such as workflow or simulation tools and SDL provides an effective interface to query and organize materials from various sources. Advanced features of the SDL allow users to visualize the provenance of the materials such as the source and how the output data is derived. Other novel features include visualizing all geo-referenced materials on a geospatial map. SDL as a component of a cyberenvironment portal (the NCSA Cybercollaboratory) has goal of efficient management of information and relationships between published artifacts (Validated models, vetted data, workflows, annotations, best practices, reviews and papers) produced from raw research artifacts (data, notes, plans etc.) through agents (people, sensors etc.). Tremendous scientific potential of artifacts is achieved through mechanisms of sharing, reuse and collaboration - empowering scientists to spread their knowledge and protocols and to benefit from the knowledge of others. SDL successfully implements web 2.0 technologies and design patterns along with semantic content management approach that enables use of multiple ontologies and dynamic evolution (e.g. folksonomies) of terminology. Scientific documents involved with

  3. Utilisation and Impact of the Essential Electronic Agricultural Database (TEEAL) on Library Services in a Nigerian University of Agriculture

    ERIC Educational Resources Information Center

    Oduwole, A. A.; Sowole, A. O.

    2006-01-01

    Purpose: This study examined the utilisation of the Essential Electronic Agricultural Library database (TEEAL) at the University of Agriculture Library, Abeokuta, Nigeria. Design/methodology/approach: Data collection was by questionnaire following a purposive sampling technique. A total of 104 out 150 (69.3 per cent) responses were received and…

  4. Utilisation and Impact of the Essential Electronic Agricultural Database (TEEAL) on Library Services in a Nigerian University of Agriculture

    ERIC Educational Resources Information Center

    Oduwole, A. A.; Sowole, A. O.

    2006-01-01

    Purpose: This study examined the utilisation of the Essential Electronic Agricultural Library database (TEEAL) at the University of Agriculture Library, Abeokuta, Nigeria. Design/methodology/approach: Data collection was by questionnaire following a purposive sampling technique. A total of 104 out 150 (69.3 per cent) responses were received and…

  5. Implementing and optimising an Electronic Library of Health Care in Belgium: results of a pilot study.

    PubMed

    Hannes, K; Vander Stichele, R H; Simons, E; Geens, S; Goedhuys, J; Aertgeerts, B

    2007-01-01

    Health care practitioners are expected to incorporate results from the best available, scientific information into their daily clinical decision-making process. Useful formats of evidence for practitioners include selected reviews, abstracts in which research results are discussed, "quick answer", evidence-based website including for example diagnostic and therapeutic algorithms, drugs prescription and non-drug therapy. An increasing amount of practitioners has access to the World Wide Web, either at home or at the office. However, easy and cheap access to objective and high quality research results is limited. Many practitioners lack the skills to efficiently navigate complicated medical databases. In 2003 an 'Electronic Library of Health Care' was introduced in Belgium. The main goal of the electronic library is to provide a gateway to scientific evidence to Belgian health care practitioners from different disciplines. This paper presents the results of a pilot project to implement the library in the field. It also describes recent developments and adjustments that increased the efficacy of this gateway to evidence.

  6. Nonlinear dynamics and bifurcation mechanisms in intense electron beam with virtual cathode

    NASA Astrophysics Data System (ADS)

    Frolov, Nikita S.; Kurkin, Semen A.; Koronovskii, Alexey A.; Hramov, Alexander E.

    2017-07-01

    In this paper we report on the results of investigations of nonlinear dynamics and bifurcation mechanisms in intense electron beam with virtual cathode in micrometer-scaled source of sub-THz electromagnetic radiation. The numerical analysis is provided by means of 3D electromagnetic particle-in-cell (PIC) simulation. We have studied evolution of the system dynamics with the change of beam current value by means of Fourier and bifurcation analysis. The bifurcation diagram has identified a number of the alternating regions of beam current with regular or chaotic regimes of system dynamics. The study of spatiotemporal dynamics of formed electron structures in the beam has revealed the physical mechanisms responsible for the regimes switchings in the system.

  7. Electronic cleansing for dual-energy CT colonography based on material decomposition and virtual monochromatic imaging

    NASA Astrophysics Data System (ADS)

    Tachibana, Rie; Näppi, Janne J.; Kim, Se Hyung; Yoshida, Hiroyuki

    2015-03-01

    CT colonography (CTC) uses orally administered fecal-tagging agents to enhance retained fluid and feces that would otherwise obscure or imitate polyps on CTC images. To visualize the complete region of colon without residual materials, electronic cleansing (EC) can be used to perform virtual subtraction of the tagged materials from CTC images. However, current EC methods produce subtraction artifacts and they can fail to subtract unclearly tagged feces. We developed a novel multi-material EC (MUMA-EC) method that uses dual-energy CTC (DE-CTC) and machine-learning methods to improve the performance of EC. In our method, material decomposition is performed to calculate wateriodine decomposition images and virtual monochromatic (VIM) images. Using the images, a random forest classifier is used to label the regions of lumen air, soft tissue, fecal tagging, and their partial-volume boundaries. The electronically cleansed images are synthesized from the multi-material and VIM image volumes. For pilot evaluation, we acquired the clinical DE-CTC data of 7 patients. Preliminary results suggest that the proposed MUMA-EC method is effective and that it minimizes the three types of image artifacts that were present in previous EC methods.

  8. JAMSTEC E-library of Deep-sea Images (J-EDI) Realizes a Virtual Journey to the Earth's Unexplored Deep Ocean

    NASA Astrophysics Data System (ADS)

    Sasaki, T.; Azuma, S.; Matsuda, S.; Nagayama, A.; Ogido, M.; Saito, H.; Hanafusa, Y.

    2016-12-01

    The Japan Agency for Marine-Earth Science and Technology (JAMSTEC) archives a large amount of deep-sea research videos and photos obtained by JAMSTEC's research submersibles and vehicles with cameras. The web site "JAMSTEC E-library of Deep-sea Images : J-EDI" (http://www.godac.jamstec.go.jp/jedi/e/) has made videos and photos available to the public via the Internet since 2011. Users can search for target videos and photos by keywords, easy-to-understand icons, and dive information at J-EDI because operating staffs classify videos and photos as to contents, e.g. living organism and geological environment, and add comments to them.Dive survey data including videos and photos are not only valiant academically but also helpful for education and outreach activities. With the aim of the improvement of visibility for broader communities, we added new functions of 3-dimensional display synchronized various dive survey data with videos in this year.New Functions Users can search for dive survey data by 3D maps with plotted dive points using the WebGL virtual map engine "Cesium". By selecting a dive point, users can watch deep-sea videos and photos and associated environmental data, e.g. water temperature, salinity, rock and biological sample photos, obtained by the dive survey. Users can browse a dive track visualized in 3D virtual spaces using the WebGL JavaScript library. By synchronizing this virtual dive track with videos, users can watch deep-sea videos recorded at a point on a dive track. Users can play an animation which a submersible-shaped polygon automatically traces a 3D virtual dive track and displays of dive survey data are synchronized with tracing a dive track. Users can directly refer to additional information of other JAMSTEC data sites such as marine biodiversity database, marine biological sample database, rock sample database, and cruise and dive information database, on each page which a 3D virtual dive track is displayed. A 3D visualization of a dive

  9. A report of work activities on the NASA Spacelink public electronic library

    NASA Technical Reports Server (NTRS)

    Smith, Willard A.

    1994-01-01

    NASA Spacelink is a comprehensive electronic data base of NASA and other source educational and informational materials. This service originates at Marshall Space Flight Center (MSFC) in Huntsville, Alabama. This is an education service of NASA Headquarters, through the MSFC Education Office, that first began in February of 1988. The new NASA Spacelink Public Electronic Library was the result of a study conducted to investigate an upgrade or redesign of the original NASA Spacelink. The UNIX Operating System was chosen to be the host operating system for the new NASA Spacelink Public Electronic Library. The UNIX system was selected for this project because of the strengths built into the embedded communication system and for its simple and direct file handling capabilities. The host hardware of the new system is a Sun Microsystems SPARCserver 1000 computer system. The configuration has four 50-MHz SuperSPARC processors with 128 megabytes of shared memory; three SB800 serial ports allowing 24 cable links for phone communications; 4.1 gigabytes of on-line disk storage; and ten (10) CD-ROM drives. Communications devices on the system are sufficient to support the expected number of users through the Internet, the local dial services, long distance dial services; the MSFC PABX, and the NPSS (NASA Packet Switching System) and 1-800 access service for the registered teachers.

  10. National Information Infrastructure of a Science, Culture and Education: Representation of Resources of Electronic Libraries

    NASA Astrophysics Data System (ADS)

    Filinov, E.; Boychenko, A.

    In the report are given questions concerned the choice of international standards for electronic libraries construction: - The alternative variants of choice standards on electronic catalogs and metacatalogs formats; - The alternative variants of choice standards for interlibrary loan; - The variants of choice standards for information search in online public catalogs (OPAC) and bibliographic databases; - The variants of choice standards for file representation of full text documents, vector and raster images, audio- and video-materials, text of public distributed programs. The questions for public discussion by interested organizations are intended to represent on special web site. The profile of electronic library as a total combination of standards on program interfaces and protocols may be constructed with the conceptual model of EL. This model is offered as a expansion of basic open systems environment / reference model (OSE/RM) for the area of applications to describe the Application Program Interface (APIs). Opinions of the interested organizations, which will be collected on a site by way of discussion of the questions put above, it is supposed to base on formation of a national information infrastructure of Russia for science, culture and education.

  11. "Scientific Kazan" as a Prototype of Electronic Library for Science and Education

    NASA Astrophysics Data System (ADS)

    Elizarov, A. M.; Nikiforov, N. A.; Yakubov, T. E.

    Kazan internet-based project "Scientific Kazan" was initially started in 2000 and introduced the idea of central web-portal for the scientific society of the city. Every city with 1+ million population and large number of scientific and educational institutions has a need in accumulating and exchanging information within this scientific society. Web-portal has passed through several phases of improvements and now includes several services and mechanisms for effective information exchange, creating electronic collections and libraries. This paper describes the stages of "Scientific Kazan" development, its achievements and future perspectives.

  12. Comparing Library and User Related Costs of Print and Electronic Journal Collections; Open Citation Linking; Toward a Global Digital Library; Information Retrieval by Semantic Analysis and Visualization of the Concept Space of D-Lib[R] Magazine.

    ERIC Educational Resources Information Center

    Montgomery, Carol Hansen; King, Donald W.; Hitchcock, Steve; Brody, Tim; Carr, Les; Gutteridge, Christopher; Hall, Wendy; Harnad, Stevan; Bergmark, Donna; Lagoze, Carl; Fox, Edward A.; Moore, Reagan W.; Larsen, Ronald L.; Myaeng, Sung Hyon; Kim, Sung-Hyuk; Zhang, Junliang; Mostafa, Javed; Tripathy, Himansu

    2002-01-01

    Includes four articles that discuss the impact of academic libraries' shift to electronic journals on staff and costs; open citation linking for improved access and the Open Archives Initiative; development of global digital libraries, particularly between the United States and Korea; and retrieving documents from a digital library through a…

  13. A theoretical-electron-density databank using a model of real and virtual spherical atoms.

    PubMed

    Nassour, Ayoub; Domagala, Slawomir; Guillot, Benoit; Leduc, Theo; Lecomte, Claude; Jelsch, Christian

    2017-08-01

    A database describing the electron density of common chemical groups using combinations of real and virtual spherical atoms is proposed, as an alternative to the multipolar atom modelling of the molecular charge density. Theoretical structure factors were computed from periodic density functional theory calculations on 38 crystal structures of small molecules and the charge density was subsequently refined using a density model based on real spherical atoms and additional dummy charges on the covalent bonds and on electron lone-pair sites. The electron-density parameters of real and dummy atoms present in a similar chemical environment were averaged on all the molecules studied to build a database of transferable spherical atoms. Compared with the now-popular databases of transferable multipolar parameters, the spherical charge modelling needs fewer parameters to describe the molecular electron density and can be more easily incorporated in molecular modelling software for the computation of electrostatic properties. The construction method of the database is described. In order to analyse to what extent this modelling method can be used to derive meaningful molecular properties, it has been applied to the urea molecule and to biotin/streptavidin, a protein/ligand complex.

  14. A support vector machines approach for virtual screening of active compounds of single and multiple mechanisms from large libraries at an improved hit-rate and enrichment factor.

    PubMed

    Han, L Y; Ma, X H; Lin, H H; Jia, J; Zhu, F; Xue, Y; Li, Z R; Cao, Z W; Ji, Z L; Chen, Y Z

    2008-06-01

    Support vector machines (SVM) and other machine-learning (ML) methods have been explored as ligand-based virtual screening (VS) tools for facilitating lead discovery. While exhibiting good hit selection performance, in screening large compound libraries, these methods tend to produce lower hit-rate than those of the best performing VS tools, partly because their training-sets contain limited spectrum of inactive compounds. We tested whether the performance of SVM can be improved by using training-sets of diverse inactive compounds. In retrospective database screening of active compounds of single mechanism (HIV protease inhibitors, DHFR inhibitors, dopamine antagonists) and multiple mechanisms (CNS active agents) from large libraries of 2.986 million compounds, the yields, hit-rates, and enrichment factors of our SVM models are 52.4-78.0%, 4.7-73.8%, and 214-10,543, respectively, compared to those of 62-95%, 0.65-35%, and 20-1200 by structure-based VS and 55-81%, 0.2-0.7%, and 110-795 by other ligand-based VS tools in screening libraries of >or=1 million compounds. The hit-rates are comparable and the enrichment factors are substantially better than the best results of other VS tools. 24.3-87.6% of the predicted hits are outside the known hit families. SVM appears to be potentially useful for facilitating lead discovery in VS of large compound libraries.

  15. Connecting Distance Learning Communities to Research via Virtual Collaboratories: A Case Study from Library and Information Science

    ERIC Educational Resources Information Center

    Rebmann, Kristen

    2012-01-01

    This case study reports on patterns of participation in a virtual collaboratory organised around goals associated with the involvement of graduate students in research and writing projects. Traditionally, distance learning classrooms have been devoted to teaching content matter (in a virtual context) yet this case study reports on the use of…

  16. Connecting Distance Learning Communities to Research via Virtual Collaboratories: A Case Study from Library and Information Science

    ERIC Educational Resources Information Center

    Rebmann, Kristen

    2012-01-01

    This case study reports on patterns of participation in a virtual collaboratory organised around goals associated with the involvement of graduate students in research and writing projects. Traditionally, distance learning classrooms have been devoted to teaching content matter (in a virtual context) yet this case study reports on the use of…

  17. International Coalition of Library Consortia Statement of Current Perspective and Preferred Practices for the Selection and Purchase of Electronic Information.

    ERIC Educational Resources Information Center

    Online Libraries and Microcomputers, 1998

    1998-01-01

    The International Coalition of Library Consortia statement on provision of electronic information addresses current problems, needs for the future, and preferred practices in the emerging electronic-information environment. Specific topics include increasing expectations, budgets, fair use, archiving, the scholarly communications system, pricing,…

  18. User satisfaction survey and usage of an electronic desktop document delivery service at an academic medical library.

    PubMed

    Sayed, Ellen N; Murray, Sarah D

    2003-01-01

    In June 2000, the Biomedical Library at the University of South Alabama introduced Prospero, an electronic desktop document delivery service. From June 2000 to November 2002, Prospero delivered 28% of interlibrary loan requests and 72% of document delivery requests. In November 2002, the library conducted a user satisfaction survey of the Prospero service. Forty-two surveys were used. Fifteen responses were received from affiliated faculty, staff, and students, who generally expressed satisfaction with the service. Twenty-seven responses were received from unaffiliated users, comprised of medical libraries, individual users, and businesses. Based on the survey results, the library deemed the Prospero service a success. To better support users, the library's Web page was updated to include hardware and software requirements for successful use of the Prospero service, as well as screen shots of the Prospero process.

  19. TEMPy: a Python library for assessment of three-dimensional electron microscopy density fits

    PubMed Central

    Farabella, Irene; Vasishtan, Daven; Joseph, Agnel Praveen; Pandurangan, Arun Prasad; Sahota, Harpal; Topf, Maya

    2015-01-01

    Three-dimensional electron microscopy is currently one of the most promising techniques used to study macromolecular assemblies. Rigid and flexible fitting of atomic models into density maps is often essential to gain further insights into the assemblies they represent. Currently, tools that facilitate the assessment of fitted atomic models and maps are needed. TEMPy (template and electron microscopy comparison using Python) is a toolkit designed for this purpose. The library includes a set of methods to assess density fits in intermediate-to-low resolution maps, both globally and locally. It also provides procedures for single-fit assessment, ensemble generation of fits, clustering, and multiple and consensus scoring, as well as plots and output files for visualization purposes to help the user in analysing rigid and flexible fits. The modular nature of TEMPy helps the integration of scoring and assessment of fits into large pipelines, making it a tool suitable for both novice and expert structural biologists. PMID:26306092

  20. Managing Electronic Serials: Essays Based on the ALCTS Electronic Serials Institutes 1997-1999. ALCTS Papers on Library Technical Services & Collections, No. 9.

    ERIC Educational Resources Information Center

    Bluh, Pamela M., Ed.

    If managed well, electronic journals (e-journals) can be extremely efficient, saving money and space while improving access and speeding information delivery. With the help of the Internet, e-journals can also make library collections more accessible to both users and staff. Covering the process of managing electronic serials from licensing,…

  1. Searching for Electronic Journal Articles to Support Academic Tasks. A Case Study of the Use of the Finnish National Electronic Library (FinELib)

    ERIC Educational Resources Information Center

    Vakkari, Pertti; Talja, Sanna

    2006-01-01

    Introduction: We analyse how academic status and discipline influence the major search methods used by university academic staff for obtaining electronic articles for teaching, research and keeping up to date in their field. Method: The data consist of a nationwide Web-survey of the end-users of FinELib, The Finnish National Electronic Library.…

  2. Web 2.0 as Catalyst: Virtually Reaching Out to Users and Connecting Them to Library Resources and Services

    ERIC Educational Resources Information Center

    Xiao, Norah

    2008-01-01

    This article is based on services to library users in the area of chemistry at the Science and Engineering (S&E) Library of the University of Southern California (USC), to which I applied various new technologies as outreach approaches. Various Web 2.0 technologies such as a blog, tags, YouTube, RSS feeds, Instant Messaging, online…

  3. Web 2.0 as Catalyst: Virtually Reaching Out to Users and Connecting Them to Library Resources and Services

    ERIC Educational Resources Information Center

    Xiao, Norah

    2008-01-01

    This article is based on services to library users in the area of chemistry at the Science and Engineering (S&E) Library of the University of Southern California (USC), to which I applied various new technologies as outreach approaches. Various Web 2.0 technologies such as a blog, tags, YouTube, RSS feeds, Instant Messaging, online…

  4. School Libraries Are Essential: Meeting the Virtual Access and Collaboration Needs of the 21st-Century Learner and Teacher

    ERIC Educational Resources Information Center

    Darrow, Rob

    2009-01-01

    School librarians have excelled in providing a physical library space that is welcoming, making sure students have an inviting space to access print and digital materials, and developing collections that provide access for all ages of students. In the physical library space services such as collaborating with teachers and consulting with students…

  5. Virtual Power Electronics: Novel Software Tools for Design, Modeling and Education

    NASA Astrophysics Data System (ADS)

    Hamar, Janos; Nagy, István; Funato, Hirohito; Ogasawara, Satoshi; Dranga, Octavian; Nishida, Yasuyuki

    The current paper is dedicated to present browser-based multimedia-rich software tools and e-learning curriculum to support the design and modeling process of power electronics circuits and to explain sometimes rather sophisticated phenomena. Two projects will be discussed. The so-called Inetele project is financed by the Leonardo da Vinci program of the European Union (EU). It is a collaborative project between numerous EU universities and institutes to develop state-of-the art curriculum in Electrical Engineering. Another cooperative project with participation of Japanese, European and Australian institutes focuses especially on developing e-learning curriculum, interactive design and modeling tools, furthermore on development of a virtual laboratory. Snapshots from these two projects will be presented.

  6. Building a Gateway for the CD-ROM Network: A Step toward the Virtual Library with the Virtual Microsystems V-Server.

    ERIC Educational Resources Information Center

    Sylvia, Margaret

    1993-01-01

    Describes one college library's experience with a gateway for dial-in access to its CD-ROM network to increase access to automated index searching for students off-campus. Hardware and software choices are discussed in terms of access, reliability, affordability, and ease of use. Installation problems are discussed, and an appendix lists product…

  7. The ELPA library: scalable parallel eigenvalue solutions for electronic structure theory and computational science.

    PubMed

    Marek, A; Blum, V; Johanni, R; Havu, V; Lang, B; Auckenthaler, T; Heinecke, A; Bungartz, H-J; Lederer, H

    2014-05-28

    Obtaining the eigenvalues and eigenvectors of large matrices is a key problem in electronic structure theory and many other areas of computational science. The computational effort formally scales as O(N(3)) with the size of the investigated problem, N (e.g. the electron count in electronic structure theory), and thus often defines the system size limit that practical calculations cannot overcome. In many cases, more than just a small fraction of the possible eigenvalue/eigenvector pairs is needed, so that iterative solution strategies that focus only on a few eigenvalues become ineffective. Likewise, it is not always desirable or practical to circumvent the eigenvalue solution entirely. We here review some current developments regarding dense eigenvalue solvers and then focus on the Eigenvalue soLvers for Petascale Applications (ELPA) library, which facilitates the efficient algebraic solution of symmetric and Hermitian eigenvalue problems for dense matrices that have real-valued and complex-valued matrix entries, respectively, on parallel computer platforms. ELPA addresses standard as well as generalized eigenvalue problems, relying on the well documented matrix layout of the Scalable Linear Algebra PACKage (ScaLAPACK) library but replacing all actual parallel solution steps with subroutines of its own. For these steps, ELPA significantly outperforms the corresponding ScaLAPACK routines and proprietary libraries that implement the ScaLAPACK interface (e.g. Intel's MKL). The most time-critical step is the reduction of the matrix to tridiagonal form and the corresponding backtransformation of the eigenvectors. ELPA offers both a one-step tridiagonalization (successive Householder transformations) and a two-step transformation that is more efficient especially towards larger matrices and larger numbers of CPU cores. ELPA is based on the MPI standard, with an early hybrid MPI-OpenMPI implementation available as well. Scalability beyond 10,000 CPU cores for problem

  8. Lead-oriented synthesis: Investigation of organolithium-mediated routes to 3-D scaffolds and 3-D shape analysis of a virtual lead-like library.

    PubMed

    Lüthy, Monique; Wheldon, Mary C; Haji-Cheteh, Chehasnah; Atobe, Masakazu; Bond, Paul S; O'Brien, Peter; Hubbard, Roderick E; Fairlamb, Ian J S

    2015-06-01

    Synthetic routes to six 3-D scaffolds containing piperazine, pyrrolidine and piperidine cores have been developed. The synthetic methodology focused on the use of N-Boc α-lithiation-trapping chemistry. Notably, suitably protected and/or functionalised medicinal chemistry building blocks were synthesised via concise, connective methodology. This represents a rare example of lead-oriented synthesis. A virtual library of 190 compounds was then enumerated from the six scaffolds. Of these, 92 compounds (48%) fit the lead-like criteria of: (i) -1⩽AlogP⩽3; (ii) 14⩽number of heavy atoms⩽26; (iii) total polar surface area⩾50Å(2). The 3-D shapes of the 190 compounds were analysed using a triangular plot of normalised principal moments of inertia (PMI). From this, 46 compounds were identified which had lead-like properties and possessed 3-D shapes in under-represented areas of pharmaceutical space. Thus, the PMI analysis of the 190 member virtual library showed that whilst scaffolds which may appear on paper to be 3-D in shape, only 24% of the compounds actually had 3-D structures in the more interesting areas of 3-D drug space.

  9. The Electronic Welcome Mat: The Academic Library Web Site as a Marketing and Public Relations Tool

    ERIC Educational Resources Information Center

    Welch, Jeanie M.

    2005-01-01

    This article explores the potential and reality of using the academic library Web site to market library resources and services, for fundraising, and to market special events. It explores such issues as the placement of a link to academic libraries from institutional home pages and the use of a library Web site to include links to news, exhibits,…

  10. Data Management inside the Library: Assessing Electronic Resources Data Using the Data Asset Framework Methodology

    ERIC Educational Resources Information Center

    Ogier, Andi; Hall, Monena; Bailey, Annette; Stovall, Connie

    2014-01-01

    Rapidly growing within academic libraries, library data services have often been focused on assessing research trends and building partnerships outside the library. There are distinct benefits, however, to using data audit methodologies created for these external assessments of researcher practices inside the library as well. In this article, we…

  11. Data Management inside the Library: Assessing Electronic Resources Data Using the Data Asset Framework Methodology

    ERIC Educational Resources Information Center

    Ogier, Andi; Hall, Monena; Bailey, Annette; Stovall, Connie

    2014-01-01

    Rapidly growing within academic libraries, library data services have often been focused on assessing research trends and building partnerships outside the library. There are distinct benefits, however, to using data audit methodologies created for these external assessments of researcher practices inside the library as well. In this article, we…

  12. The Electronic Welcome Mat: The Academic Library Web Site as a Marketing and Public Relations Tool

    ERIC Educational Resources Information Center

    Welch, Jeanie M.

    2005-01-01

    This article explores the potential and reality of using the academic library Web site to market library resources and services, for fundraising, and to market special events. It explores such issues as the placement of a link to academic libraries from institutional home pages and the use of a library Web site to include links to news, exhibits,…

  13. Design of combinatorial libraries for the exploration of virtual hits from fragment space searches with LoFT.

    PubMed

    Lessel, Uta; Wellenzohn, Bernd; Fischer, J Robert; Rarey, Matthias

    2012-02-27

    A case study is presented illustrating the design of a focused CDK2 library. The scaffold of the library was detected by a feature trees search in a fragment space based on reactions from combinatorial chemistry. For the design the software LoFT (Library optimizer using Feature Trees) was used. The special feature called FTMatch was applied to restrict the parts of the queries where the reagents are permitted to match. This way a 3D scoring function could be simulated. Results were compared with alternative designs by GOLD docking and ROCS 3D alignments.

  14. Library Skills.

    ERIC Educational Resources Information Center

    Paul, Karin; Kuhlthau, Carol C.; Branch, Jennifer L.; Solowan, Diane Galloway; Case, Roland; Abilock, Debbie; Eisenberg, Michael B.; Koechlin, Carol; Zwaan, Sandi; Hughes, Sandra; Low, Ann; Litch, Margaret; Lowry, Cindy; Irvine, Linda; Stimson, Margaret; Schlarb, Irene; Wilson, Janet; Warriner, Emily; Parsons, Les; Luongo-Orlando, Katherine; Hamilton, Donald

    2003-01-01

    Includes 19 articles that address issues related to library skills and Canadian school libraries. Topics include information literacy; inquiry learning; critical thinking and electronic research; collaborative inquiry; information skills and the Big 6 approach to problem solving; student use of online databases; library skills; Internet accuracy;…

  15. Library Skills.

    ERIC Educational Resources Information Center

    Paul, Karin; Kuhlthau, Carol C.; Branch, Jennifer L.; Solowan, Diane Galloway; Case, Roland; Abilock, Debbie; Eisenberg, Michael B.; Koechlin, Carol; Zwaan, Sandi; Hughes, Sandra; Low, Ann; Litch, Margaret; Lowry, Cindy; Irvine, Linda; Stimson, Margaret; Schlarb, Irene; Wilson, Janet; Warriner, Emily; Parsons, Les; Luongo-Orlando, Katherine; Hamilton, Donald

    2003-01-01

    Includes 19 articles that address issues related to library skills and Canadian school libraries. Topics include information literacy; inquiry learning; critical thinking and electronic research; collaborative inquiry; information skills and the Big 6 approach to problem solving; student use of online databases; library skills; Internet accuracy;…

  16. The Primary Care Electronic Library: RSS feeds using SNOMED-CT indexing for dynamic content delivery.

    PubMed

    Robinson, Judas; de Lusignan, Simon; Kostkova, Patty; Madge, Bruce; Marsh, A; Biniaris, C

    2006-01-01

    Rich Site Summary (RSS) feeds are a method for disseminating and syndicating the contents of a website using extensible mark-up language (XML). The Primary Care Electronic Library (PCEL) distributes recent additions to the site in the form of an RSS feed. When new resources are added to PCEL, they are manually assigned medical subject headings (MeSH terms), which are then automatically mapped to SNOMED-CT terms using the Unified Medical Language System (UMLS) Metathesaurus. The library is thus searchable using MeSH or SNOMED-CT. Our syndicate partner wished to have remote access to PCEL coronary heart disease (CHD) information resources based on SNOMED-CT search terms. To pilot the supply of relevant information resources in response to clinically coded requests, using RSS syndication for transmission between web servers. Our syndicate partner provided a list of CHD SNOMED-CT terms to its end-users, a list which was coded according to UMLS specifications. When the end-user requested relevant information resources, this request was relayed from our syndicate partner's web server to the PCEL web server. The relevant resources were retrieved from the PCEL MySQL database. This database is accessed using a server side scripting language (PHP), which enables the production of dynamic RSS feeds on the basis of Source Asserted Identifiers (CODEs) contained in UMLS. Retrieving resources using SNOMED-CT terms using syndication can be used to build a functioning application. The process from request to display of syndicated resources took less than one second. The results of the pilot illustrate that it is possible to exchange data between servers using RSS syndication. This method could be utilised dynamically to supply digital library resources to a clinical system with SNOMED-CT data used as the standard of reference.

  17. Charting a Course through CORAL: Texas A&M University Libraries' Experience Implementing an Open-Source Electronic Resources Management System

    ERIC Educational Resources Information Center

    Hartnett, Eric; Beh, Eugenia; Resnick, Taryn; Ugaz, Ana; Tabacaru, Simona

    2013-01-01

    In 2010, after two previous unsuccessful attempts at electronic resources management system (ERMS) implementation, Texas A&M University (TAMU) Libraries set out once again to find an ERMS that would fit its needs. After surveying the field, TAMU Libraries selected the University of Notre Dame Hesburgh Libraries-developed, open-source ERMS,…

  18. Charting a Course through CORAL: Texas A&M University Libraries' Experience Implementing an Open-Source Electronic Resources Management System

    ERIC Educational Resources Information Center

    Hartnett, Eric; Beh, Eugenia; Resnick, Taryn; Ugaz, Ana; Tabacaru, Simona

    2013-01-01

    In 2010, after two previous unsuccessful attempts at electronic resources management system (ERMS) implementation, Texas A&M University (TAMU) Libraries set out once again to find an ERMS that would fit its needs. After surveying the field, TAMU Libraries selected the University of Notre Dame Hesburgh Libraries-developed, open-source ERMS,…

  19. Local imaging of high mobility two-dimensional electron systems with virtual scanning tunneling microscopy

    SciTech Connect

    Pelliccione, M.; Bartel, J.; Goldhaber-Gordon, D.; Sciambi, A.; Pfeiffer, L. N.; West, K. W.

    2014-11-03

    Correlated electron states in high mobility two-dimensional electron systems (2DESs), including charge density waves and microemulsion phases intermediate between a Fermi liquid and Wigner crystal, are predicted to exhibit complex local charge order. Existing experimental studies, however, have mainly probed these systems at micron to millimeter scales rather than directly mapping spatial organization. Scanning probes should be well-suited to study the spatial structure of these states, but high mobility 2DESs are found at buried semiconductor interfaces, beyond the reach of conventional scanning tunneling microscopy. Scanning techniques based on electrostatic coupling to the 2DES deliver important insights, but generally with resolution limited by the depth of the 2DES. In this letter, we present our progress in developing a technique called “virtual scanning tunneling microscopy” that allows local tunneling into a high mobility 2DES. Using a specially designed bilayer GaAs/AlGaAs heterostructure where the tunnel coupling between two separate 2DESs is tunable via electrostatic gating, combined with a scanning gate, we show that the local tunneling can be controlled with sub-250 nm resolution.

  20. Optimizing electronic standard cell libraries for variability tolerance through the nano-CMOS grid.

    PubMed

    Walker, James Alfred; Sinnott, Richard; Stewart, Gordon; Hilder, James A; Tyrrell, Andy M

    2010-08-28

    The project Meeting the Design Challenges of nano-CMOS Electronics (http://www.nanocmos.ac.uk) was funded by the Engineering and Physical Sciences Research Council to tackle the challenges facing the electronics industry caused by the decreasing scale of transistor devices, and the inherent variability that this exposes in devices and in the circuits and systems in which they are used. The project has developed a grid-based solution that supports the electronics design process, incorporating usage of large-scale high-performance computing (HPC) resources, data and metadata management and support for fine-grained security to protect commercially sensitive datasets. In this paper, we illustrate how the nano-CMOS (complementary metal oxide semiconductor) grid has been applied to optimize transistor dimensions within a standard cell library. The goal is to extract high-speed and low-power circuits which are more tolerant of the random fluctuations that will be prevalent in future technology nodes. Using statistically enhanced circuit simulation models based on three-dimensional atomistic device simulations, a genetic algorithm is presented that optimizes the device widths within a circuit using a multi-objective fitness function exploiting the nano-CMOS grid. The results show that the impact of threshold voltage variation can be reduced by optimizing transistor widths, and indicate that a similar method could be extended to the optimization of larger circuits.

  1. Arriba-lib: evaluation of an electronic library of decision aids in primary care physicians.

    PubMed

    Hirsch, Oliver; Keller, Heidemarie; Krones, Tanja; Donner-Banzhoff, Norbert

    2012-06-06

    The successful implementation of decision aids in clinical practice initially depends on how clinicians perceive them. Relatively little is known about the acceptance of decision aids by physicians and factors influencing the implementation of decision aids from their point of view. Our electronic library of decision aids (arriba-lib) is to be used within the encounter and has a modular structure containing evidence-based decision aids for the following topics: cardiovascular prevention, atrial fibrillation, coronary heart disease, oral antidiabetics, conventional and intensified insulin therapy, and unipolar depression. The aim of our study was to evaluate the acceptance of arriba-lib in primary care physicians. We conducted an evaluation study in which 29 primary care physicians included 192 patients. The physician questionnaire contained information on which module was used, how extensive steps of the shared decision making process were discussed, who made the decision, and a subjective appraisal of consultation length. We used generalised estimation equations to measure associations within patient variables and traditional crosstab analyses. Only a minority of consultations (8.9%) was considered to be unacceptably extended. In 90.6% of consultations, physicians said that a decision could be made. A shared decision was perceived by physicians in 57.1% of consultations. Physicians said that a decision was more likely to be made when therapeutic options were discussed "detailed". Prior experience with decision aids was not a critical variable for implementation within our sample of primary care physicians. Our study showed that it might be feasible to apply our electronic library of decision aids (arriba-lib) in the primary care context. Evidence-based decision aids offer support for physicians in the management of medical information. Future studies should monitor the long-term adoption of arriba-lib in primary care physicians.

  2. arriba-lib: evaluation of an electronic library of decision aids in primary care physicians

    PubMed Central

    2012-01-01

    Background The successful implementation of decision aids in clinical practice initially depends on how clinicians perceive them. Relatively little is known about the acceptance of decision aids by physicians and factors influencing the implementation of decision aids from their point of view. Our electronic library of decision aids (arriba-lib) is to be used within the encounter and has a modular structure containing evidence-based decision aids for the following topics: cardiovascular prevention, atrial fibrillation, coronary heart disease, oral antidiabetics, conventional and intensified insulin therapy, and unipolar depression. The aim of our study was to evaluate the acceptance of arriba-lib in primary care physicians. Methods We conducted an evaluation study in which 29 primary care physicians included 192 patients. The physician questionnaire contained information on which module was used, how extensive steps of the shared decision making process were discussed, who made the decision, and a subjective appraisal of consultation length. We used generalised estimation equations to measure associations within patient variables and traditional crosstab analyses. Results Only a minority of consultations (8.9%) was considered to be unacceptably extended. In 90.6% of consultations, physicians said that a decision could be made. A shared decision was perceived by physicians in 57.1% of consultations. Physicians said that a decision was more likely to be made when therapeutic options were discussed “detailed”. Prior experience with decision aids was not a critical variable for implementation within our sample of primary care physicians. Conclusions Our study showed that it might be feasible to apply our electronic library of decision aids (arriba-lib) in the primary care context. Evidence-based decision aids offer support for physicians in the management of medical information. Future studies should monitor the long-term adoption of arriba-lib in primary care

  3. Texas Instruments' virtual phase charge-coupled device (CCD) imager operated in the frontside electron-bombarded mode

    NASA Technical Reports Server (NTRS)

    Everett, P.; Hynecek, J.; Zucchino, P.; Lowrance, J.

    1982-01-01

    The present investigation is concerned with the suitability of the virtual phase CCD imager for frontside detection of electrons up to 25 keV. The investigation has the objective to determine if the imager can be used in the frontside mode with a photocathode to detect very low light levels in astronomical applications, the ultimate goal being individual photon detection. It is found that the standard virtual phase imager will function properly over an extended period at low levels of 20 kV electron irradiation consistent with photon counting applications. The imager can detect individual primary electrons with nearly 100 percent efficiency. However, further studies are needed to determine the mechanisms for the flat band shifts so that the imager design may be modified to eliminate or at least reduce them.

  4. Academic Libraries, 2000. E.D. Tabs.

    ERIC Educational Resources Information Center

    Carey, Nancy; Justh, Natalie M.; Williams, Jeffrey W.

    This report discusses the state of academic libraries in 2000. It defines "academic library" as well as discusses library services, library collections, library staff, library expenditures, and electronic services. (Author/AMT)

  5. Virtual Libraries: Virtual Communities. Abstracts, Fulltext Documents and PowerPoint Presentations of Papers and Demos Given at the International Association of Technological University Libraries (IATUL) Conference (Brisbane, Queensland, Australia, July 3-7, 2000).

    ERIC Educational Resources Information Center

    International Association of Technological Univ. Libraries, Gothenburg (Sweden).

    This proceedings of the International Association of Technological University Libraries (IATUL) contains the opening address by IATUL president Nancy Fjallbrant and the full text of the following papers: "Building Info-Skills by Degrees: Embedding Information Literacy in University Study" (Wendy Abbott and Deborah Peach); "UQ…

  6. Virtual Libraries: Virtual Communities. Abstracts, Fulltext Documents and PowerPoint Presentations of Papers and Demos Given at the International Association of Technological University Libraries (IATUL) Conference (Brisbane, Queensland, Australia, July 3-7, 2000).

    ERIC Educational Resources Information Center

    International Association of Technological Univ. Libraries, Gothenburg (Sweden).

    This proceedings of the International Association of Technological University Libraries (IATUL) contains the opening address by IATUL president Nancy Fjallbrant and the full text of the following papers: "Building Info-Skills by Degrees: Embedding Information Literacy in University Study" (Wendy Abbott and Deborah Peach); "UQ…

  7. Electronic Resource Expenditure and the Decline in Reference Transaction Statistics in Academic Libraries

    ERIC Educational Resources Information Center

    Dubnjakovic, Ana

    2012-01-01

    The current study investigates factors influencing increase in reference transactions in a typical week in academic libraries across the United States of America. Employing multiple regression analysis and general linear modeling, variables of interest from the "Academic Library Survey (ALS) 2006" survey (sample size 3960 academic libraries) were…

  8. Electronic Resource Expenditure and the Decline in Reference Transaction Statistics in Academic Libraries

    ERIC Educational Resources Information Center

    Dubnjakovic, Ana

    2012-01-01

    The current study investigates factors influencing increase in reference transactions in a typical week in academic libraries across the United States of America. Employing multiple regression analysis and general linear modeling, variables of interest from the "Academic Library Survey (ALS) 2006" survey (sample size 3960 academic libraries) were…

  9. How Much Space Does a Library Need? Justifying Collections Space in an Electronic Age

    ERIC Educational Resources Information Center

    Butkovich, Nancy J.

    2010-01-01

    In 2002, plans to merge Penn State's Physical Sciences Library and Mathematics Library provoked a controversy in the Eberly College of Science over the size of the library needed to support its departments. The College contended that a physical collection no more than 5 years old was adequate. A study of astronomy, chemistry, mathematics, physics,…

  10. How Much Space Does a Library Need? Justifying Collections Space in an Electronic Age

    ERIC Educational Resources Information Center

    Butkovich, Nancy J.

    2010-01-01

    In 2002, plans to merge Penn State's Physical Sciences Library and Mathematics Library provoked a controversy in the Eberly College of Science over the size of the library needed to support its departments. The College contended that a physical collection no more than 5 years old was adequate. A study of astronomy, chemistry, mathematics, physics,…

  11. The Development of an Electronic Interlibrary Loan Form at the Ohio State University Prior Health Sciences Library: A Survey.

    ERIC Educational Resources Information Center

    Lopeman, Holly

    A survey of computer hardware and software access, network familiarity, and systems use was conducted to determine the optimum placement of two newly developed electronic Interlibrary Loan (ILL) forms at the Ohio State University Health Sciences Library. A sample of 205 ILL users were mailed a questionnaire, with a resultant 72% (n=148) response…

  12. What's Everybody Talking About?: Message Functions and Topics on Electronic Lists and Newsgroups in Information and Library Science.

    ERIC Educational Resources Information Center

    Wildemuth, Barbara M.; Crenshaw, Lisa; Jenniches, William; Harmes, J. Christine

    1997-01-01

    Describes a study that analyzed 14 electronic lists or newsgroups in library and information science to find out which topics of discussion are dominant and which functions are performed by the messages posted. It also introduced students to this type of professional communication and to content analysis as a research method. Contains 51…

  13. Cataloging and Locator Services for Government Publications during the Transition to an Electronic Federal Depository Library Program.

    ERIC Educational Resources Information Center

    Downing, Thomas A.

    1996-01-01

    Discussion of the transformation of the Federal Depository Library Program from a distribution program to one for electronic access focuses on cataloging operations and new services to support the requirements of GPO Access. Highlights include standards for bibliographic control and Internet publishing. (Author/LRW)

  14. Ranking Business and Economics Journals in South America Using the Scientific Electronic Library Online (SciELO)

    ERIC Educational Resources Information Center

    Alexander, Jennifer K.; Pradenas, Lorena; Parada, Victor; Scherer, Robert F.

    2012-01-01

    Access to published research for knowledge creation and education in the administrative science disciplines in South America has been enhanced since the introduction of the Scientific Electronic Library Online (SciELO). Although SciELO has been available as an online journal indexing and publication service since 1998, there have been no…

  15. The Library's New Relevance: Fostering the First-Year Student's Acquisition, Evaluation, and Integration of Print and Electronic Materials

    ERIC Educational Resources Information Center

    Hlavaty, Greg; Townsend, Murphy

    2010-01-01

    Modern composition instructors often use and teach research methods for Internet search engines and electronic databases. It is not their intent to turn back the clock. However, if they can help students connect the world of Internet searches and the university library, they can promote information literacy in its broadest sense by developing…

  16. You Can't Get There from Here: Issues in Remote Access to Electronic Journals for a Health Sciences Library.

    ERIC Educational Resources Information Center

    Krieb, Dennis

    1999-01-01

    Discusses experiences of the Saint Louis University's Health Sciences Center Library in providing access to electronic journals to a dispersed constituency. Topics include IP (institutional password) filtering, how publishers and aggregators establish access control, credential-based authentication, and proxy servers. (Author/LRW)

  17. Ranking Business and Economics Journals in South America Using the Scientific Electronic Library Online (SciELO)

    ERIC Educational Resources Information Center

    Alexander, Jennifer K.; Pradenas, Lorena; Parada, Victor; Scherer, Robert F.

    2012-01-01

    Access to published research for knowledge creation and education in the administrative science disciplines in South America has been enhanced since the introduction of the Scientific Electronic Library Online (SciELO). Although SciELO has been available as an online journal indexing and publication service since 1998, there have been no…

  18. The Library's New Relevance: Fostering the First-Year Student's Acquisition, Evaluation, and Integration of Print and Electronic Materials

    ERIC Educational Resources Information Center

    Hlavaty, Greg; Townsend, Murphy

    2010-01-01

    Modern composition instructors often use and teach research methods for Internet search engines and electronic databases. It is not their intent to turn back the clock. However, if they can help students connect the world of Internet searches and the university library, they can promote information literacy in its broadest sense by developing…

  19. You Can't Get There from Here: Issues in Remote Access to Electronic Journals for a Health Sciences Library.

    ERIC Educational Resources Information Center

    Krieb, Dennis

    1999-01-01

    Discusses experiences of the Saint Louis University's Health Sciences Center Library in providing access to electronic journals to a dispersed constituency. Topics include IP (institutional password) filtering, how publishers and aggregators establish access control, credential-based authentication, and proxy servers. (Author/LRW)

  20. Impact of Electronic Resources and Usage in Academic Libraries in Ghana: Evidence from Koforidua Polytechnic & All Nations University College, Ghana

    ERIC Educational Resources Information Center

    Akussah, Maxwell; Asante, Edward; Adu-Sarkodee, Rosemary

    2015-01-01

    The study investigates the relationship between impact of electronic resources and its usage in academic libraries in Ghana: evidence from Koforidua Polytechnic & All Nations University College, Ghana. The study was a quantitative approach using questionnaire to gather data and information. A valid response rate of 58.5% was assumed. SPSS…

  1. Simulation of High Resolution Vibrational and Electronic Spectra with a Multifrequency Virtual Spectrometer

    NASA Astrophysics Data System (ADS)

    Biczysko, Malgorzata; Bloino, Julien; Barone, Vincenzo

    2013-06-01

    Moving from the common practice of extracting numerical data from experiment to be compared with quantum mechanical (QM) results toward a direct vis-à-vis} comparison of experimental and simulated spectra would strongly reduce any arbitrariness in analysis of complex experimental outcomes and allow a proper account of the information connected to both position and shape of spectral bands. The development of such ``virtual ab initio spectrometers'' for a wide range of wavelengths has been one of our major research goals in the last years [1,2]. Recent methodological advances from our group allow simulation of optical (IR, Raman, UV-vis, etc.) spectra line-shapes for medium-to-large closed- and open-shell molecular systems. Vibrational spectra are computed including anharmonicities through perturbative corrections while electronic spectra line-shapes are simulated accounting for the vibrational structure. Well resolved and accurate theoretical spectra provide data as close as possible to the results directly available from experiment allowing to avoid ambiguities in analysis of the latter. Several examples illustrating interpretation, assignment or revision of experimental spectra for prototypes of bio-molecular systems (phenyl radical, glycine, thymine, pyrimidine, anisole dimer) will be presented. 1. V. Barone, A. Baiardi, M. Biczysko, J. Bloino, C. Cappelli, F. Lipparini Phys. Chem. Chem. Phys, 14, 12404, 2012 2. M. Biczysko, J. Bloino, G. Brancato, et al. Theor. Chem. Acc. 113, 1201, 2012

  2. Digitization and the Creation of Virtual Libraries: The Princeton University Image Card Catalog--Reaping the Benefits of Imaging.

    ERIC Educational Resources Information Center

    Henthorne, Eileen

    1995-01-01

    Describes a project at the Princeton University libraries that converted the pre-1981 public card catalog, using digital imaging and optical character recognition technology, to fully tagged and indexed records of text in MARC format that are available on an online database and will be added to the online catalog. (LRW)

  3. Casebook: a virtual patient iPad application for teaching decision-making through the use of electronic health records

    PubMed Central

    2014-01-01

    Background Virtual Patients are a well-known and widely used form of interactive software used to simulate aspects of patient care that students are increasingly less likely to encounter during their studies. However, to take full advantage of the benefits of using Virtual Patients, students should have access to multitudes of cases. In order to promote the creation of collections of cases, a tablet application was developed which makes use of electronic health records as material for Virtual Patient cases. Because electronic health records are abundantly available on hospital information systems, this results in much material for the basis of case creation. Results An iPad-based Virtual Patient interactive software system was developed entitled Casebook. The application has been designed to read specially formatted patient cases that have been created using electronic health records, in the form of X-ray images, electrocardiograms, lab reports, and physician notes, and present these to the medical student. These health records are organised into a timeline, and the student navigates the case while answering questions regarding the patient along the way. Each health record can also be annotated with meta-information by the case designer, such as insight into the thought processes and the decision-making rationale of the physician who originally worked with the patient. Students learn decision-making skills by observing and interacting with real patient cases in this simulated environment. This paper discusses our approach in detail. Conclusions Our group is of the opinion that Virtual Patient cases, targeted at undergraduate students, should concern patients who exhibit prototypical symptoms of the kind students may encounter when beginning their first medical jobs. Learning theory research has shown that students learn decision-making skills best when they have access to multitudes of patient cases and it is this plurality that allows students to develop their

  4. Virtually distortion-free imaging system for large field, high resolution lithography using electrons, ions or other particle beams

    DOEpatents

    Hawryluk, A.M.; Ceglio, N.M.

    1993-01-12

    Virtually distortion free large field high resolution imaging is performed using an imaging system which contains large field distortion or field curvature. A reticle is imaged in one direction through the optical system to form an encoded mask. The encoded mask is then imaged back through the imaging system onto a wafer positioned at the reticle position. Particle beams, including electrons, ions and neutral particles, may be used as well as electromagnetic radiation.

  5. Virtually distortion-free imaging system for large field, high resolution lithography using electrons, ions or other particle beams

    DOEpatents

    Hawryluk, Andrew M.; Ceglio, Natale M.

    1993-01-01

    Virtually distortion free large field high resolution imaging is performed using an imaging system which contains large field distortion or field curvature. A reticle is imaged in one direction through the optical system to form an encoded mask. The encoded mask is then imaged back through the imaging system onto a wafer positioned at the reticle position. Particle beams, including electrons, ions and neutral particles, may be used as well as electromagnetic radiation.

  6. Virtual Poetry.

    ERIC Educational Resources Information Center

    Gyori, Ladislao Pablo

    1996-01-01

    Presents a manifesto proposing the creation of a new kind of poetry--virtual poetry--that exists only in electronic space and computer networks. States that this new poetry is interactive, animated, hyper-linked, and navigational. (PA)

  7. Dynamic-Stark-effect-induced coherent mixture of virtual paths in laser-dressed helium: energetic electron impact excitation

    NASA Astrophysics Data System (ADS)

    Agueny, Hicham; Makhoute, Abdelkader; Dubois, Alain

    2017-06-01

    We theoretically investigate quantum virtual path interference caused by the dynamic Stark effect in bound-bound electronic transitions. The effect is studied in an intermediate resonant region and in connection with the energetic electron impact excitation of a helium atom embedded in a weak low-frequency laser field. The process under investigation is dealt with via a Born-Floquet approach. Numerical calculations show a resonant feature in laser-assisted cross sections. The latter is found to be sensitive to the intensity of the laser field dressing. We show that this feature is a signature of quantum beats which result from the coherent mixture of different quantum virtual pathways, and that excitation may follow in order to end up with a common final channel. This mixture arises from the dynamic Stark effect, which produces a set of avoided crossings in laser-dressed states. The effect allows one to coherently control quantum virtual path interference by varying the intensity of the laser field dressing. Our findings suggest that the combination of an energetic electron and a weak laser field is a useful tool for the coherent control of nonadiabatic transitions in an intermediate resonant region.

  8. Characterization of the phantom material Virtual Water{sup TM} in high-energy photon and electron beams

    SciTech Connect

    McEwen, M.R.; Niven, D.

    2006-04-15

    The material Virtual Water{sup TM} has been characterized in photon and electron beams. Range-scaling factors and fluence correction factors were obtained, the latter with an uncertainty of around 0.2%. This level of uncertainty means that it may be possible to perform dosimetry in a solid phantom with an accuracy approaching that of measurements in water. Two formulations of Virtual Water{sup TM} were investigated with nominally the same elemental composition but differing densities. For photon beams neither formulation showed exact water equivalence--the water/Virtual Water{sup TM} dose ratio varied with the depth of measurement with a difference of over 1% at 10 cm depth. However, by using a density (range) scaling factor very good agreement (<0.2%) between water and Virtual Water{sup TM} at all depths was obtained. In the case of electron beams a range-scaling factor was also required to match the shapes of the depth dose curves in water and Virtual Wate{sup TM}. However, there remained a difference in the measured fluence in the two phantoms after this scaling factor had been applied. For measurements around the peak of the depth-dose curve and the reference depth this difference showed some small energy dependence but was in the range 0.1%-0.4%. Perturbation measurements have indicated that small slabs of material upstream of a detector have a small (<0.1% effect) on the chamber reading but material behind the detector can have a larger effect. This has consequences for the design of experiments and in the comparison of measurements and Monte Carlo-derived values.

  9. Summer Library Reading Programs

    ERIC Educational Resources Information Center

    Fiore, Carole D.

    2007-01-01

    Virtually all public libraries in the United States provide some type of summer library reading program during the traditional summer vacation period. Summer library reading programs provide opportunities for students of many ages and abilities to practice their reading skills and maintain skills that are developed during the school year. Fiore…

  10. Changing State Digital Libraries

    ERIC Educational Resources Information Center

    Pappas, Marjorie L.

    2006-01-01

    Research has shown that state virtual or digital libraries are evolving into websites that are loaded with free resources, subscription databases, and instructional tools. In this article, the author explores these evolving libraries based on the following questions: (1) How user-friendly are the state digital libraries?; (2) How do state digital…

  11. Performing continuous quality improvement for a digital health sciences library through an electronic mail analysis.

    PubMed Central

    D'Alessandro, D M; Qian, F; D'Alessandro, M P; Ostrem, S F; Choi, T A; Erkonen, W E; Galvin, J R

    1998-01-01

    BACKGROUND: The goal of this prospective, cross-sectional study was to determine the user demographics of a digital health sciences library (DHSL), motives for use, the nature of users information requests, and success rate in finding answers. METHODS: The content of 500 consecutive electronic mail messages (e-mails) submitted to a DHSL were analyzed using a predetermined coding scheme. Data were entered into a database and frequency analysis was performed. RESULTS: The number of information requests from the 500 e-mail messages was 751. The largest sender category was patients and laypersons followed by students, then physicians. Motivations for use were primarily medical advice (42.8%) and patient care (13.8%). E-mail subject areas were mainly medical (61.8%) and technical (20.6%). Answers to information requests were found 54.3% of the time and senders felt the DHSL was valuable (97.8%). CONCLUSIONS: A DHSL is a valuable medical resource. DHSLs must serve the broad information needs of patients and laypersons in addition to health care providers. Developers and managers of DHSLs can use this information to guide future development of DHSL information content and services, as has been done at The University of Iowa. PMID:9803305

  12. The RightPages Service: An Image-Based Electronic Library.

    ERIC Educational Resources Information Center

    Hoffman, Melia M.; And Others

    1993-01-01

    Describes The RightPages Service developed by AT&T Bell Laboratories library and computer researchers to enable AT&T employees to access the library from their workstations. The service incorporates ASCII text, bitmap images, and an alerting service. Copyright issues, user interface, image and text processing procedures, results, and…

  13. Library Event Matching event classification algorithm for electron neutrino interactions in the NOνA detectors

    NASA Astrophysics Data System (ADS)

    Backhouse, C.; Patterson, R. B.

    2015-04-01

    We describe the Library Event Matching classification algorithm implemented for use in the NOνA νμ →νe oscillation measurement. Library Event Matching, developed in a different form by the earlier MINOS experiment, is a powerful approach in which input trial events are compared to a large library of simulated events to find those that best match the input event. A key feature of the algorithm is that the comparisons are based on all the information available in the event, as opposed to higher-level derived quantities. The final event classifier is formed by examining the details of the best-matched library events. We discuss the concept, definition, optimization, and broader applications of the algorithm as implemented here. Library Event Matching is well-suited to the monolithic, segmented detectors of NOνA and thus provides a powerful technique for event discrimination.

  14. Libraries in North Dakota: MedlinePlus

    MedlinePlus

    ... this page: https://medlineplus.gov/libraries/northdakota.html Libraries in North Dakota To use the sharing features ... please enable JavaScript. Fargo SANFORD HEALTH SANFORD VIRTUAL LIBRARY 530 6th Ave N FARGO, ND 58102 701- ...

  15. Realizing the Hybrid Library.

    ERIC Educational Resources Information Center

    Pinfield, Stephen; Eaton, Jonathan; Edwards, Catherine; Russell, Rosemary; Wissenburg, Astrid; Wynne, Peter

    1998-01-01

    Outlines five projects currently funded by the United Kingdom's Electronic Libraries Program (eLib): HyLiFe (Hybrid Library of the Future), MALIBU (MAnaging the hybrid Library for the Benefit of Users), HeadLine (Hybrid Electronic Access and Delivery in the Library Networked Environment), ATHENS (authentication scheme), and BUILDER (Birmingham…

  16. Adaptive Correction from Virtually Complex Dynamic Libraries: The Role of Noncovalent Interactions in Structural Selection and Folding.

    PubMed

    Lafuente, Maria; Atcher, Joan; Solà, Jordi; Alfonso, Ignacio

    2015-11-16

    The hierarchical self-assembling of complex molecular systems is dictated by the chemical and structural information stored in their components. This information can be expressed through an adaptive process that determines the structurally fittest assembly under given environmental conditions. We have set up complex disulfide-based dynamic covalent libraries of chemically and topologically diverse pseudopeptidic compounds. We show how the reaction evolves from very complex mixtures at short reaction times to the almost exclusive formation of a major compound, through the establishment of intramolecular noncovalent interactions. Our experiments demonstrate that the systems evolve through error-check and error-correction processes. The nature of these interactions, the importance of the folding and the effects of the environment are also discussed.

  17. "Do Users Do What They Think They Do?"- A Comparative Study of User Perceived and Actual Information Searching Behaviour in the National Electronic Library of Infection

    NASA Astrophysics Data System (ADS)

    Roy, Anjana; Kostkova, Patty; Catchpole, Mike; Carson, Ewart

    In the last decade, the Internet has profoundly changed the delivery of healthcare. Medical websites for professionals and patients are playing an increasingly important role in providing the latest evidence-based knowledge for professionals, facilitating virtual patient support groups, and providing an invaluable information source for patients. Information seeking is the key user activity on the Internet. However, the discrepancy between what information is available and what the user is able to find has a profound effect on user satisfaction. The UK National electronic Library of Infection (NeLI, www.neli.org.uk) and its subsidiary projects provide a single-access portal for quality-appraised evidence in infectious diseases. We use this national portal, as test-bed for investigating our research questions. In this paper, we investigate actual and perceived user navigation behaviour that reveals important information about user perceptions and actions, in searching for information. Our results show: (i) all users were able to access information they were seeking; (ii) broadly, there is an agreement between "reported" behaviour (from questionnaires) and "observed" behaviour (from web logs), although some important differences were identified; (iii) both browsing and searching were equally used to answer specific questions and (iv) the preferred route for browsing for data on the NeLI website was to enter via the "Top Ten Topics" menu option. These findings provide important insights into how to improve user experience and satisfaction with health information websites.

  18. Characteristics of personal health records: findings of the Medical Library Association/National Library of Medicine Joint Electronic Personal Health Record Task Force.

    PubMed

    Jones, Dixie A; Shipman, Jean P; Plaut, Daphne A; Selden, Catherine R

    2010-07-01

    The Medical Library Association (MLA)/National Library of Medicine (NLM) Joint Electronic Personal Health Record Task Force examined the current state of personal health records (PHRs). A working definition of PHRs was formulated, and a database was built with fields for specified PHR characteristics. PHRs were identified and listed. Each task force member was assigned a portion of the list for data gathering. Findings were recorded in the database. Of the 117 PHRs identified, 91 were viable. Almost half were standalone products. A number used national standards for nomenclature and/or record structure. Less than half were mobile device enabled. Some were publicly available, and others were offered only to enrollees of particular health plans or employees at particular institutions. A few were targeted to special health conditions. The PHR field is very dynamic. While most PHR products have some common elements, their features can vary. PHRs can link their users with librarians and information resources. MLA and NLM have taken an active role in making this connection and in encouraging librarians to assume this assistance role with PHRs.

  19. Characteristics of personal health records: findings of the Medical Library Association/National Library of Medicine Joint Electronic Personal Health Record Task Force

    PubMed Central

    Shipman, Jean P; Plaut, Daphne A; Selden, Catherine R

    2010-01-01

    Objectives: The Medical Library Association (MLA)/National Library of Medicine (NLM) Joint Electronic Personal Health Record Task Force examined the current state of personal health records (PHRs). Methods: A working definition of PHRs was formulated, and a database was built with fields for specified PHR characteristics. PHRs were identified and listed. Each task force member was assigned a portion of the list for data gathering. Findings were recorded in the database. Results: Of the 117 PHRs identified, 91 were viable. Almost half were standalone products. A number used national standards for nomenclature and/or record structure. Less than half were mobile device enabled. Some were publicly available, and others were offered only to enrollees of particular health plans or employees at particular institutions. A few were targeted to special health conditions. Conclusions: The PHR field is very dynamic. While most PHR products have some common elements, their features can vary. PHRs can link their users with librarians and information resources. MLA and NLM have taken an active role in making this connection and in encouraging librarians to assume this assistance role with PHRs. PMID:20648259

  20. Depository Library Collections and Services in an Electronic Age: A Review of the Literature.

    ERIC Educational Resources Information Center

    Hernon, Peter

    1987-01-01

    This examination of the literature that discusses technological applications for the collections and services of depository libraries identifies areas treated in the literature and topics for further writing and research. (Author/CLB)