Science.gov

Sample records for vitae lewis nelson

  1. Geologic map of the Nelson quadrangle, Lewis and Clark County, Montana

    USGS Publications Warehouse

    Reynolds, Mitchell W.; Hays, William H.

    2003-01-01

    The geologic map of the Nelson quadrangle, scale 1:24,000, was prepared as part of the Montana Investigations Project to provide new information on the stratigraphy, structure, and geologic history of an area in the geologically complex southern part of the Montana disturbed belt. In the Nelson area, rocks ranging in age from Middle Proterozoic through Cretaceous are exposed on three major thrust plates in which rocks have been telescoped eastward. Rocks within the thrust plates are folded and broken by thrust faults of smaller displacement than the major bounding thrust faults. Middle and Late Tertiary sedimentary and volcaniclastic rocks unconformably overlie the pre-Tertiary rocks. A major normal fault displaces rocks of the western half of the quadrangle down on the west with respect to strata of the eastern part. Alluvial and terrace gravels and local landslide deposits are present in valley bottoms and on canyon walls in the deeply dissected terrain. Different stratigraphic successions are exposed at different structural levels across the quadrangle. In the northeastern part, strata of the Middle Cambrian Flathead Sandstone, Wolsey Shale, and Meagher Limestone, the Middle and Upper Cambrian Pilgrim Formation and Park Shale undivided, the Devonian Maywood, Jefferson, and lower part of the Three Forks Formation, and Lower and Upper Mississippian rocks assigned to the upper part of the Three Forks Formation and the overlying Lodgepole and Mission Canyon Limestones are complexly folded and faulted. These deformed strata are overlain structurally in the east-central part of the quadrangle by a succession of strata including the Middle Proterozoic Greyson Formation and the Paleozoic succession from the Flathead Sandstone upward through the Lodgepole Limestone. In the east-central area, the Flathead Sandstone rests unconformably on the middle part of the Greyson Formation. The north edge, northwest quarter, and south half of the quadrangle are underlain by a

  2. Meet EPA's Dan Nelson

    EPA Pesticide Factsheets

    EPA’s Dan Nelson is the Director of the Human Research Protocol Office at the National Health and Environmental Effect Research Laboratory, Dan works to protect the rights and welfare of EPA’s research participants.

  3. Writing your curriculum vitae.

    PubMed

    McKenzie, S

    2001-09-01

    Your curriculum vitae (CV) is your gateway to shortlisting. A good CV takes a long time to prepare. It should not only record your training but, more importantly, should reflect your 'physicianly' qualities, management skills and knowledge of health-care systems.

  4. Marilyn Nelson: Poetic Justice

    ERIC Educational Resources Information Center

    Pierpont, Katherine

    2006-01-01

    This article features some of the books written by Marilyn Nelson. Here, the author discusses how she has written a children's book of poetry about lynching, entitled "A Wreath for Emmitt Till." The author discusses how her books for children honor and memorialize history-changing African Americans. Among other things, the author discusses some of…

  5. Nelson's syndrome in pregnancy

    SciTech Connect

    Surrey, E.S.; Chang, R.J.

    1985-10-01

    The therapeutic considerations in the management of Nelson's syndrome in a 29 year old primigravida are described. CT scans revealed a 2-cm solid pituitary lesion with suprasellar extension and chiasmatic encroachment. A transsphenoidal hypophysectomy was performed to remove a eosinophilic pituitary adenoma. The patient's symptoms improved following surgery. Fetal growth was followed by ultrasound and a female infant was delivered by cesarean section. Follow-up CT scan 2 weeks after delivery revealed no evidence of tumor recurrence.

  6. Nelson syndrome: definition and management.

    PubMed

    Barber, T M; Adams, E; Wass, J A H

    2014-01-01

    Nelson syndrome is an important complication of treatment with total bilateral adrenalectomy (TBA) for patients with refractory Cushing's disease. Although early cases of Nelson syndrome often presented with the clinical features of large sellar masses, the modern face of Nelson syndrome has changed primarily due to earlier detection (with highly resolved magnetic resonance imaging (MRI) and sensitive ACTH assays) and greater awareness of the condition, resulting in reduced morbidity and mortality. Although lack of administration of neoadjuvant pituitary radiotherapy post-TBA surgery may predict future development of Nelson syndrome, other predictive factors remain controversial. Therefore, Nelson syndrome should be screened for closely and long-term in all patients with a history of Cushing's disease and TBA. The diagnosis of Nelson syndrome remains controversial, and the pathogenesis of this condition is incompletely understood. Current hypotheses include the "released negative feedback" mechansism (residual pituitary corticotropinoma cells are "released" from the negative feedback effects of cortisol following TBA), and the "aggressive corticotropinoma" mechanism (Nelson syndrome is most likely to develop in those patients with refractory treatments - including TBA - for an underlying aggressive corticotropinoma). Effective management of Nelson syndrome with pituitary surgery and radiotherapy is often a challenge. Other therapies (such as Gamma Knife surgery and temozolomide) play an important role and merit further research into their efficacy and placement in the management pathway of Nelson syndrome.

  7. The digital curriculum vitae.

    PubMed

    Galdino, Greg M; Gotway, Michael

    2005-02-01

    The curriculum vitae (CV) has been the traditional method for radiologists to illustrate their accomplishments in the field of medicine. Despite its presence in medicine as a standard, widely accepted means to describe one's professional career and its use for decades as an accomplice to most applications and interviews, there is relatively little written in the medical literature regarding the CV. Misrepresentation on medical students', residents', and fellows' applications has been reported. Using digital technology, CVs have the potential to be much more than printed words on paper and offers a solution to misrepresentation. Digital CVs may incorporate full-length articles, graphics, presentations, clinical images, and video. Common formats for digital CVs include CD-ROMs or DVD-ROMs containing articles (in Adobe Portable Document Format) and presentations (in Microsoft PowerPoint format) accompanying printed CVs, word processing documents with hyperlinks to articles and presentations either locally (on CD-ROMs or DVD-ROMs) or remotely (via the Internet), or hypertext markup language documents. Digital CVs afford the ability to provide more information that is readily accessible to those receiving and reviewing them. Articles, presentations, videos, images, and Internet links can be illustrated using standard file formats commonly available to all radiologists. They can be easily updated and distributed on an inexpensive media, such as a CD-ROM or DVD-ROM. With the availability of electronic articles, presentations, and information via the Internet, traditional paper CVs may soon be superseded by their electronic successors.

  8. Curriculum Vitae and Related Letters.

    ERIC Educational Resources Information Center

    Peterson, Sharyl Bender

    This booklet, which was developed by a college career center, explains the purpose of and procedures for writing curriculum vitae (CV) and related letters. The following topics are covered: when a CV is appropriate, points to consider when writing a CV, items usually included, possible sections to include in a CV, and steps in writing cover…

  9. The "Curriculum Vitae": An Imperfect Mirror.

    ERIC Educational Resources Information Center

    Bennett, John B.

    1992-01-01

    Curriculum vitae for college faculty can be ambiguous and even misleading: they can obscure an individual's primary teaching and instructional achievements, tell less than they appear to, and convey an unintended message. Faculty should evaluate the clarity and force with which their vitae express their accomplishments and mirror their abilities.…

  10. A curriculum vitae: making your best impression.

    PubMed

    Harvey, C

    1993-01-01

    Describing yourself on paper is an important marketing tool for the nurse for professional opportunities today. Using a curriculum vitae (CV) serves to best illustrate relevant experiences that a nurse has had toward fulfillment of a professional objective. A readable, truthful, and polished curriculum vitae and cover letter can help nurses present themselves in a very positive manner.

  11. HPEC Related VITA Standards: An Update

    DTIC Science & Technology

    2004-09-30

    HPEC Related VITA Standards: An Update Randy Banton Mercury Computer Systems, Inc. High Performance Embedded Computing (HPEC) Conference September...AND ADDRESS(ES) Mercury Computer Systems, Inc. 8. PERFORMING ORGANIZATION REPORT NUMBER 9. SPONSORING/MONITORING AGENCY NAME(S) AND ADDRESS(ES) 10...unclassified c. THIS PAGE unclassified Standard Form 298 (Rev. 8-98) Prescribed by ANSI Std Z39-18 2© 2004 Mercury Computer Systems, Inc. HPEC Related VITA

  12. Nelson River and Hudson Bay

    NASA Technical Reports Server (NTRS)

    2002-01-01

    Rivers that empty into large bodies of water can have a significant impact on the thawing of nearshore winter ice. This true-color Moderate Resolution Imaging Spectroradiometer (MODIS) image from May 18, 2001, shows the Nelson River emptying spring runoff from the Manitoba province to the south into the southwestern corner of Canada's Hudson Bay. The warmer waters from more southern latitudes hasten melting of ice near the shore, though some still remained, perhaps because in shallow coastal waters, the ice could have been anchored to the bottom. High volumes of sediment in the runoff turned the inflow brown, and the rim of the retreating ice has taken on a dirty appearance even far to the east of the river's entrance into the Bay. The sediment would have further hastened the melting of the ice because its darker color would have absorbed more solar radiation than cleaner, whiter ice. Image courtesy Jacques Descloitres, MODIS Land Rapid Response Team at NASA GSFC

  13. Nelson syndrome: historical perspectives and current concepts.

    PubMed

    Hornyak, Mark; Weiss, Martin H; Nelson, Don H; Couldwell, William T

    2007-01-01

    The appearance of an adrenocorticotropic hormone (ACTH)-producing tumor after bilateral adrenalectomy for Cushing disease was first described by Nelson in 1958. The syndrome that now bears his name was characterized by hyperpigmentation, a sellar mass, and increased plasma ACTH levels. The treatment of Cushing disease has changed drastically since the 1950s, when the choice was adrenalectomy. Thus, the occurrence, diagnosis, and treatment of Nelson syndrome have changed as well. In the modern era of high-resolution neuroimaging, transsphenoidal microneurosurgery, and stereotactic radiosurgery, Nelson syndrome has become a rare entity. The authors describe the history of the diagnosis and treatment of Nelson syndrome. In light of the changes described, the authors believe this disease must be reevaluated in the contemporary era and a modern paradigm adopted.

  14. A Day in the Life at DaVita Academy

    ERIC Educational Resources Information Center

    Weinstein, Margery

    2010-01-01

    When a company name means "giving life," the bar for learning and development programs is held high. In this article, the author describes what it takes to graduate from DaVita Academy, the soft skills training program dialysis services company DaVita offers all its employees. DaVita's chief executive officer, Kent Thiry, states that the Academy…

  15. 7 CFR 3402.15 - Faculty vitae.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 7 Agriculture 15 2010-01-01 2010-01-01 false Faculty vitae. 3402.15 Section 3402.15 Agriculture Regulations of the Department of Agriculture (Continued) COOPERATIVE STATE RESEARCH, EDUCATION, AND EXTENSION SERVICE, DEPARTMENT OF AGRICULTURE FOOD AND AGRICULTURAL SCIENCES NATIONAL NEEDS GRADUATE AND...

  16. 7 CFR 3402.15 - Faculty vitae.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 7 Agriculture 15 2011-01-01 2011-01-01 false Faculty vitae. 3402.15 Section 3402.15 Agriculture Regulations of the Department of Agriculture (Continued) NATIONAL INSTITUTE OF FOOD AND AGRICULTURE FOOD AND AGRICULTURAL SCIENCES NATIONAL NEEDS GRADUATE AND POSTGRADUATE FELLOWSHIP GRANTS PROGRAM Preparation of...

  17. PHP-HT (VitaResc Biotech).

    PubMed

    Baldwin, A; Wiley, E

    2001-04-01

    VitaResc (formerly Apex) is developing PHP-HT, pyridoxalated hemoglobin polyoxyethylene conjugate, for the potential treatment of nitric oxide-induced shock (characterized by hypotension), associated with various etiologies, initially in septic shock. A phase I safety study and an initial phase I/II patient trial for NO-induced shock have been completed, and VitaResc has enrolled patients in three of five planned cohorts in a continuation of these trials to include a protocol of continuous infusion and dose escalation [330680,349187,390918]. The results from the dose escalation trials are expected to provide the basis for a randomized, controlled phase II/III pivotal trial of PHP-HT [390918]. VitaResc has licensed PHP-HT exclusively from Ajinomoto for all indications, worldwide, except Japan [275263]. Ajinomoto originally developed the human derived and chemically modified hemoglobin preparation as a blood substitute, but no development has been reported by the company since 1997 [275277,303577]. The other potential indications of PHP-HT include shock associated with burns, pancreatitis, hemodialysis and cytokine therapies [275277]. VitaResc expects the annual market potential of PHP-HT to exceed 1 billion dollars [330680].

  18. 7 CFR 3402.15 - Faculty vitae.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 7 Agriculture 15 2014-01-01 2014-01-01 false Faculty vitae. 3402.15 Section 3402.15 Agriculture Regulations of the Department of Agriculture (Continued) NATIONAL INSTITUTE OF FOOD AND AGRICULTURE FOOD AND AGRICULTURAL SCIENCES NATIONAL NEEDS GRADUATE AND POSTGRADUATE FELLOWSHIP GRANTS PROGRAM Preparation of...

  19. 7 CFR 3402.15 - Faculty vitae.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 7 Agriculture 15 2012-01-01 2012-01-01 false Faculty vitae. 3402.15 Section 3402.15 Agriculture Regulations of the Department of Agriculture (Continued) NATIONAL INSTITUTE OF FOOD AND AGRICULTURE FOOD AND AGRICULTURAL SCIENCES NATIONAL NEEDS GRADUATE AND POSTGRADUATE FELLOWSHIP GRANTS PROGRAM Preparation of...

  20. 7 CFR 3402.15 - Faculty vitae.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 7 Agriculture 15 2013-01-01 2013-01-01 false Faculty vitae. 3402.15 Section 3402.15 Agriculture Regulations of the Department of Agriculture (Continued) NATIONAL INSTITUTE OF FOOD AND AGRICULTURE FOOD AND AGRICULTURAL SCIENCES NATIONAL NEEDS GRADUATE AND POSTGRADUATE FELLOWSHIP GRANTS PROGRAM Preparation of...

  1. Lewy Body Disease

    MedlinePlus

    Lewy body disease is one of the most common causes of dementia in the elderly. Dementia is the loss of mental ... to affect normal activities and relationships. Lewy body disease happens when abnormal structures, called Lewy bodies, build ...

  2. 78 FR 75205 - Death of Nelson Mandela

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-12-10

    ... lost an incomparable liberator, and the world has lost an inspiration for freedom, justice, and human.... His journey from a prisoner to a President embodied the promise that human beings--and countries--can.... While we mourn his loss, we will forever honor Nelson Mandela's memory. He left behind a South...

  3. A Conversation with Harold L. Nelson.

    ERIC Educational Resources Information Center

    Journalism History, 1979

    1979-01-01

    In this interview, Harold L. Nelson, former president of the Association for Education in Journalism and the American Association of Schools and Departments of Journalism, discusses a number of topics, including press freedom, research needs in journalism history, United States media history, and the current status of journalism history. (GT)

  4. Philosophical Remarks on Nelson Mandela's Education Legacy

    ERIC Educational Resources Information Center

    Waghid, Yusef

    2014-01-01

    In this article, I reflect on Nelson Mandela's (Madiba, the clan name of Mandela) education legacy. I argue that Madiba's education legacy is constituted by three interrelated aspects: firstly, an education for non-violence guided by deliberation, compassion and reconciliation; secondly, education as responsibility towards the Other; and thirdly,…

  5. Lewy bodies

    PubMed Central

    Shults, Clifford W.

    2006-01-01

    Lewy bodies (LB) in the substantia nigra are a cardinal pathological feature of Parkinson's disease, but they occur in a number of neurodegenerative diseases and can be widespread in the nervous system. The characteristics, locations, and composition of LB are reviewed, with particular attention to α-synuclein (α-SYN), which appears to be the major component of LB. The propensity for α-SYN, a presynaptic protein widely expressed in the brain, to aggregate is because of an amyloidogenic central region. The factors that favor the aggregation of α-SYN and mechanisms of toxicity are examined, and a mechanism through which aggregates of α-SYN could induce mitochondrial dysfunction and/or release of proapoptotic molecules is proposed. PMID:16449387

  6. The curriculum vitae sending the right message.

    PubMed

    Shellenbarger, Teresa; Chunta, Kristy S

    2007-01-01

    When reviewing curriculum vitae (CV), it becomes clear that some CV information provides a better reflection of work completed than others do. The authors provide a description of common CV errors, propose strategies to avoid such problems, and suggest methods for developing an accurate and clear CV that highlights accomplishments and clearly represents the work. Tips for updating CV and suggestions for electronic formats are also provided.

  7. A resume or curriculum vitae for success.

    PubMed

    Markey, B T; Campbell, R L

    1996-01-01

    Nurses who are searching for new positions can enhance their job employment potential with well-written resumes. Scholarship and award recognition also can be improved by creating well-written resumes and/or curricula vitae. Appropriate cover letters effectively introduce nurses to employers or review committees. This article presents a few basic suggestions that can simplify the creation of any of these documents and help nurses produce a quality product.

  8. [Curriculum vitae organization: the Lattes software platform].

    PubMed

    Amorin, Cristiane V

    2003-05-01

    Curriculum vitae is a Latin expression meaning "career" or "life course". That means the data set concerning name, age, marital status, situation, studies, diplomas, published works and other activities of a student, an applicant for a position, for an exam or for a public office, and others. In short, it is the document that provides an outlook of the person as an individual; that is why this document must be carefully prepared as to precise and true contents, as to presentation and as to writing.

  9. A professional curriculum vitae will open career doors.

    PubMed

    Harper, D S

    1999-01-01

    In today's challenging healthcare environment, it is essential for nurse practitioners to be able to describe themselves professionally on paper to compete for practice and academic opportunities. Nurse practitioners are competing with physician assistants as well as physicians for primary and acute care positions. A carefully compiled curriculum vitae will present the individual in the best light possible to help open career doors and enhance chances of success. Preparing a curriculum vitae will serve to highlight relevant professional accomplishments, whatever the setting, toward the fulfillment of professional goals. This article reviews the current professional print and electronic literature on preparing a curriculum vitae to assist the nurse practitioner in developing this vital document.

  10. Nelson`s syndrome associated with a somatic frame shift mutation in the glucocorticoid recepter gene

    SciTech Connect

    Karl, M.; Stratakis, C.A.; Chrousos, G.P.; Katz, D.A.; Ali, I.U.; Oldfield, E.H.

    1996-01-01

    Nelson`s syndrome is the appearance and/or progression of ACTH-secreting pituitary macroadenomas in patients who had previously undergone bilateral adrenalectomy for Cushing`s disease. Extremely high plasma ACTH levels and aggressive neoplastic growth might be explained by the lack of appropriate glucocorticoid negative feedback due to defective glucocorticoid signal transduction. To study the glucocorticoid receptor (GR) gene in Nelson`s syndrome, DNA was extracted from pituitary adenomas and leukocytes of four patients with this condition and amplified by PCR for direct sequence analysis. In one of the tumors, a heterozygous mutation, consisting of an insertion of a thymine between complementary DNA nucleotides 1188 and 1189, was found in exon 2. This frame-shift mutation led to premature termination at amino acid residue 366 of the world-type coding sequence, excluding the expression of a functioning receptor protein from the defective allele. The mutation was not detected in the sequence of the GR gene in the patient`s leukocyte DNA, indicating a somatic origin. By lowering the receptor number in tumorous cells, this defect might have caused local resistance to negative glucocorticoid feedback similar to that caused by the presence of a null allele in a kindred with the generalized glucocorticoid resistance syndrome. P53 protein accumulation, previously reported in 60% of corticotropinomas, could not be detected in any of the four pituitary tumors examined by immunohistochemistry. We suggest that a somatic GR defect might have played a pathophysiological role in the tumorigenesis of the corticotropinoma bearing this mutation. 35 refs., 3 figs., 1 tab.

  11. Rutherford's curriculum vitae, 1894-1907.

    PubMed

    Cohen, M

    1995-06-01

    A single page, handwritten document was discovered when the Macdonald Physics building of McGill University in Montreal was gutted in 1978. This proved to be the draft of Ernest Rutherford's curriculum vitae (C.V.) covering the years 1894-1907, probably written in the autumn of 1906 when Rutherford was preparing to leave McGill. The C.V. contains 21 headings in chronological order, referring to research and other activities of Rutherford and his coauthors (especially Soddy and Barnes), plus a further set of headings relating to the associated investigations of Rutherford's team, including Eve and Hahn. A transcript of the document is provided, although in several places, Rutherford's handwriting is difficult to interpret, and the significance of his abbreviations is not always clear. Each of the items in the C.V. is discussed briefly in this review, in the light both of Rutherford's personal career and of the contribution of his team to the development and understanding of radioactivity. This contribution included the cause and nature of radioactivity (with Soddy), energy aspects of radioactive decay (with Barnes), elucidation of the uranium-radium, thorium and actinium series (Godlewski and Hahn), the radioactivity of the earth and atmosphere (Eve), the nature of the gamma rays (Eve) and, perhaps most important of all, the nature and properties of the alpha particle (Rutherford himself). The latter investigations led directly to Rutherford's later work in Manchester, including the nuclear model of the atom and artificial disintegration of the nucleus.

  12. Bernard Lewis: An Appreciation.

    ERIC Educational Resources Information Center

    Humphreys, R. Stephen

    1990-01-01

    Discusses the career and publications of Bernard Lewis, a noted scholar in the field of Middle-Eastern studies and Islamic history. Traces the history of Western-based Islamic historiography. Examines Lewis' interpretation of Islamic history, outlining his political and social views. (RW)

  13. Discovering Lewis and Clark

    ERIC Educational Resources Information Center

    Olsen, Ken

    2006-01-01

    Writer and historian Bernard DeVoto observed more than 50 years ago that a dismaying amount of American history has been written without regards to the Indians. Such disregard is glaring in many mainstream stories of Meriwether Lewis and William Clark. Lewis and Clark began preparing for their historic journey in 1803 and officially launched the…

  14. 4. Historic American Buildings Survey, Nelson E. Baldwin, Photographer April ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    4. Historic American Buildings Survey, Nelson E. Baldwin, Photographer April 30, 1936, VIEW-OLD KITCHEN FIREPLACE AND OVEN, RICE HOMESTEAD, RICEVILLE, N.Y. - Rice Homestead, Route 30, Mayfield, Fulton County, NY

  15. 2. Historic American Buildings Survey, Nelson E. Baldwin, Photographer April ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    2. Historic American Buildings Survey, Nelson E. Baldwin, Photographer April 30, 1936, VIEW-REAR AND SIDE ELEVATIONS, RICE HOMESTEAD, RICEVILLE, N Y. - Rice Homestead, Route 30, Mayfield, Fulton County, NY

  16. 1. Historic American Buildings Survey, Nelson E. Baldwin, Photographer April ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    1. Historic American Buildings Survey, Nelson E. Baldwin, Photographer April 30, 1937, VIEW-FRONT ELEVATION AND SIDE, RICE HOMESTEAD, RICEVILLE, N.Y. - Rice Homestead, Route 30, Mayfield, Fulton County, NY

  17. 23. Historic American Buildings Survey, Nov. 9, 1936, Nelson E. ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    23. Historic American Buildings Survey, Nov. 9, 1936, Nelson E. Baldwin, Photographer, (P) INTERIOR, FIREPLACE FROM OLD HELP KITCHEN, IN BASEMENT OF HOUSE. - Johnson Hall, Johnstown, Fulton County, NY

  18. Astronauts van Hoften and Nelson conduct pre-breathing exercise

    NASA Technical Reports Server (NTRS)

    1984-01-01

    Astronauts James D. van Hoften and George D. Nelson, wearing Shuttle launch and entry helmets, conduct a pre-breathing exercise on the forward flight deck of the shuttle Challenger during the STS 41-C mission.

  19. Auxiliary power controls on the Nelson River HVDC scheme

    SciTech Connect

    Chand, J. )

    1992-02-01

    This paper describes the auxiliary power controls on the Nelson River HVDC scheme. It shows how the fast control feature of the HVDC link can be utilized to enhance the operation of an integrated ac/dc power system.

  20. 1. Historic American Buildings Survey, Nelson E. Baldwin, Photographer May ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    1. Historic American Buildings Survey, Nelson E. Baldwin, Photographer May 12, 1936, VIEW-FRONT ELEVATION, BURR HOUSE, GLOVERSVILLE, N Y. - Nathaniel Burr House, 153 Kingsboro Avenue, Gloversville, Fulton County, NY

  1. 2. Historic American Buildings Survey, Nelson E. Baldwin, Photographer May ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    2. Historic American Buildings Survey, Nelson E. Baldwin, Photographer May 12, 1936, VIEW-HIGHBOY AND WOODWORK, BURR HOUSE, GLOVERSVILLE, N Y. - Nathaniel Burr House, 153 Kingsboro Avenue, Gloversville, Fulton County, NY

  2. 2. Historic American Buildings Survey, Nelson E. Baldwin, Photographer Jan. ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    2. Historic American Buildings Survey, Nelson E. Baldwin, Photographer Jan. 16, 1937, View-Fireplace in Living Room The Hermitage, Columbia County, N.Y. - The Hermitage, Linlithgo Hamlet Vicinity, Blue Store, Columbia County, NY

  3. 4. Historic American Buildings Survey, Nelson E. Baldwin, Photographer Jan. ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    4. Historic American Buildings Survey, Nelson E. Baldwin, Photographer Jan. 16, 1937, View-Fireplace in Library-The Hermitage Linlithgo, Columbia, N Y . - The Hermitage, Linlithgo Hamlet Vicinity, Blue Store, Columbia County, NY

  4. 3. Historic American Buildings Survey, Nelson E. Baldwin, Photographer Jan. ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    3. Historic American Buildings Survey, Nelson E. Baldwin, Photographer Jan. 16, 1937, View-Fireplace in Living Room-The Hermitage, Linlithgo, Columbia County, N Y . - The Hermitage, Linlithgo Hamlet Vicinity, Blue Store, Columbia County, NY

  5. 1. Historic American Buildings Survey, Nelson E. Baldwin, Photographer Jan. ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    1. Historic American Buildings Survey, Nelson E. Baldwin, Photographer Jan. 16, 1937, View-Front Elevation-The Hermitage Linlithgo, Columbia County, N Y . - The Hermitage, Linlithgo Hamlet Vicinity, Blue Store, Columbia County, NY

  6. 5. Historic American Buildings Survey, Nelson E. Baldwin, Photographer Jan. ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    5. Historic American Buildings Survey, Nelson E. Baldwin, Photographer Jan. 16, 1937, View-Dutch Oven, Basement of the Hermitage, Linlithgo, Columbia County, N.Y. - The Hermitage, Linlithgo Hamlet Vicinity, Blue Store, Columbia County, NY

  7. David Nelson, MD, MPH | Division of Cancer Prevention

    Cancer.gov

    Dr. David E Nelson is the Director of the Cancer Prevention Fellowship Program (CPFP) Branch in the National Cancer Institute's Division of Cancer Prevention. The CPFP is an internationally renowned postdoctoral program designed to train early career scientific researchers and leaders in the field of cancer prevention. Dr. Nelson came to the CPFP in 2008 after working at the Centers for Disease Control and Prevention in Atlanta for many years. |

  8. 75 FR 25314 - Community Volunteer Income Tax Assistance (VITA) Matching Grant Program-Availability of...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-05-07

    ... Internal Revenue Service Community Volunteer Income Tax Assistance (VITA) Matching Grant Program... Income Tax Assistance (VITA) Matching Grant Program, which was published in the Federal Register on... packages for the 2011 Community Volunteer Income Tax Assistance (VITA) Matching Grant Program. FOR...

  9. Curriculum vitae: An important tool for the nurse practitioner.

    PubMed

    Hicks, Rodney W; Roberts, Mary Ellen E

    2016-07-01

    Advanced practice nurses (APNs) should maintain a curriculum vitae (CV) that comprehensively reflects the individual's work and professional accomplishments. This article guides APNs through best practices for development of a CV. Tips are offered to help guide the content, format, and maintenance of the CV.

  10. Curriculum Vitae: A Discourse of Celebration with Narcissistic Allusions

    ERIC Educational Resources Information Center

    Basthomi, Yazid

    2012-01-01

    The present study, a part of a larger project, deals with the under-researched (sub) genre of curriculum vitae (CV) of theses written in English by Indonesian students of English as a foreign language (EFL). The corpus was composed of CV of 40 theses obtainable from the Graduate Library, Graduate Program, "Universitas Negeri Malang"…

  11. Ten steps to writing curriculum vitae covering letters.

    PubMed

    Pearce, Chris

    2007-12-01

    As guides for recruiters, the covering letters of applicants' curricula vitae (CVs) can be almost as important as the CVs themselves. When applying for posts therefore, you should regard the writing of such letters as an opportunity to distinguish yourself from other candidates.

  12. Writing a curriculum vitae, resume or data sheet.

    PubMed

    Saltman, D

    1995-02-01

    This paper outlines a method for the preparation of a curriculum vitae, resume or data sheet, which is an essential document for professional people seeking employment or promotion. However, it needs to be accurate and relevant to the circumstances of the position, and requires regular updating.

  13. VITA Experiential, Service-Learning, Learned Competencies, and Changed Mindsets

    ERIC Educational Resources Information Center

    Boneck, Robin; Barnes, Jeffrey N.; Stillman, Tyler F.

    2014-01-01

    The authors describe how Southern Utah University has integrated the U.S. Internal Revenue Service (IRS) Voluntary Income Tax Assistance (VITA) program as an experiential servicelearning activity for over a decade and a half. First, we describe the value of experiential servicelearning. Second, we detail the program, its oversight, its student…

  14. U.S. Rep. Bill Nelson of Florida during medical tests at JSC's Clinic

    NASA Technical Reports Server (NTRS)

    1985-01-01

    U.S. Rep. Bill Nelson of Florida during medical tests at JSC's Clinic. Photos include Rep. Nelson talking to Sharon Briceno (center) and Betty Lord before the tests begin. The congressman's torso bears a number of sensors for the testing (40835); Portrait view of Rep. Nelson with sensors attached to his chest (40836); Rep. Nelson gets some assistance from nurses at the clinic as he prepares to participate in medical tests. Help is provided by Betty Lord, right, and Sharon Briceno (40837); Rep. Nelson is being assisted to don 'halo' device for tests (40838); Rep. Nelson runs in place on a treadmill device (40839).

  15. STS-26 Mission Specialist Nelson in LES prior to JSC WETF emergency exercises

    NASA Technical Reports Server (NTRS)

    1988-01-01

    STS-26 Discovery, Orbiter Vehicle (OV) 103, Mission Specialist (MS) George D. Nelson, wearing newly designed (navy blue) launch and entry suit (LES), gets some moral support from Aimee Tess Nelson, his sixteen-year-old lifeguard daughter. Nelson was about to participate in a simulation of escape and rescue operations utilizing the crew escape system (CES) pole mode of egress from the Space Shuttle. Nelson is equipped with the LES partial pressure suit and parachute gear.

  16. 1. Historic American Buildings Survey, Nelson E. Baldwin, Photographer, Jan. ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    1. Historic American Buildings Survey, Nelson E. Baldwin, Photographer, Jan. 16, 1937, View - Stairway from First to Second Floor Old Homeopathic Hospital (Office of the HABS), Albany, N.Y. - Old Homeopathic Hospital (Interiors), 123 North Pearl Street, Albany, Albany County, NY

  17. 4. Historic American Buildings Survey, Nelson E. Baldwin, Photographer, Jan. ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    4. Historic American Buildings Survey, Nelson E. Baldwin, Photographer, Jan. 16, 1937, View - Second to Third Floor Stairs Old Homeopathic Hospital, 123 North Pearl St., Albany, N.Y. - Old Homeopathic Hospital (Interiors), 123 North Pearl Street, Albany, Albany County, NY

  18. 3. Historic American Buildings Survey, Nelson E. Baldwin, Photographer, Jan. ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    3. Historic American Buildings Survey, Nelson E. Baldwin, Photographer, Jan. 16, 1937, View - Double Doors and Columns in Apartment on First Floor, 123 North Pearl St., Albany, N.Y. - Old Homeopathic Hospital (Interiors), 123 North Pearl Street, Albany, Albany County, NY

  19. 2. Historic American Buildings Survey, Nelson E. Baldwin, Photographer, Jan. ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    2. Historic American Buildings Survey, Nelson E. Baldwin, Photographer, Jan. 16, 1937, View - Interior Door Opening into Apartment on First Floor, 123 North Pearl St., Albany, N.Y. - Old Homeopathic Hospital (Interiors), 123 North Pearl Street, Albany, Albany County, NY

  20. John Nelson Darby: His Contributions to Evangelical Christian Higher Education

    ERIC Educational Resources Information Center

    Sutherland, Winston Terrance

    2010-01-01

    The study reported in this article focused on the contributions of John Nelson Derby to biblical hermeneutics and contemporary eschatological thought. Darby continues to exert a great influence on Christianity, particularly conservative evangelical Christianity. This research provides a discussion of Darby's contributions to contemporary…

  1. Corner Office Interview: SirsiDynix's Rautenstrauch and Nelson

    ERIC Educational Resources Information Center

    Rapp, David; Fialkoff, Francine

    2010-01-01

    This article presents an interview with SirsiDynix CEO Gary M. Rautenstrauch and newly appointed VP of library relations Berit Nelson about some of the issues that have been roiling the ILS world and the company itself, among them the recent consolidation of SirsiDynix's offices, customer service, the state of library budgets, the rise of ebooks…

  2. A Good Time: A Conversation with C. Michael Nelson

    ERIC Educational Resources Information Center

    Zabel, Robert; Kaff, Marilyn; Teagarden, Jim

    2015-01-01

    C. Michael Nelson began his special education career as a teacher of adolescents with learning and behavior disorders. He has worked as a child psychologist and as a professor with the Department of Special Education and Rehabilitation Counseling at the University of Kentucky. He coordinated the graduate Personnel Preparation Program for Teachers…

  3. John Nelson Darby: Scholarship that Influenced the Bible College Movement

    ERIC Educational Resources Information Center

    Sutherland, Winston Terrance

    2010-01-01

    The study reported in this article focused on the scholastic life of John Nelson Darby and his contributions to the Bible college movement. Darby continues to exert a great influence on Christianity, particularly conservative evangelical Christianity. This research provides a discussion of the forces that conspired to shape the direction of…

  4. In Honor of Eyak: The Art of Anna Nelson Harry.

    ERIC Educational Resources Information Center

    Krauss, Michael E., Ed.

    Ten stories, in poem and narrative form, told by Anna Nelson Harry, are presented here. The stories represent a portion of the oral tradition of the Eyak, an Alaskan native nation of which few native speakers remain. An introductory section chronicles the history and decline of the Eyak, the research undertaken to preserve their culture, and the…

  5. Lewy Body Dementia Diagnosis

    MedlinePlus

    ... as part of their protocols. Participating in research studies is a good way to benefit others with Lewy body dementia. Medications Medications are one of the most controversial subjects in dealing with LBD. A medication that doesn't work for one person may work for another person. ...

  6. A model curriculum vitae: what are the trainers looking for?

    PubMed

    Chambler, A F; Chapman-Sheath, P J; Pearse, M F

    1998-04-01

    In this new era of Calman, the curriculum vitae (CV) still remains the most important document in furthering the careers of doctors. A survey of postgraduate deans and college regional training advisors opinions on CVs was undertaken. The results have allowed a model CV to be compiled expressing the layout and most of the features which senior trainers feel are important when producing a CV.

  7. A curriculum vitae that gives you a competitive edge.

    PubMed

    Hinck, S M

    1997-07-01

    All nurses with advancing careers should maintain a current curriculum vitae (CV) to chronicle professional accomplishments. Whatever the work setting, a CV can showcase skills and achievements. It is used when applying for a new position, but also within one's current situation to inform other professionals of specific interests and abilities. This article reviews nursing literature regarding preparation of a CV and suggests a format for the advanced practice nurse to use when writing a CV.

  8. Application of VitaVallis dressing for infected wounds

    NASA Astrophysics Data System (ADS)

    Kirilova, N. V.; Fomenko, A. N.; Korovin, M. S.

    2015-11-01

    Today there is a growing demand for safe and efficient antimicrobial dressings for infected wound treatment. The antimicrobial sorption material for VitaVallis dressings was produced by one-stage oxidation of aluminum nanopowder in water in the presence of fibrous acetylcellulose matrix. Scanning electron microscopy revealed that the material is made up of fibers of diameter 1.5-3.0 µm with adhered agglomerated alumina nanosheets. An antimicrobial study revealed a high inhibitory effect of VitaVallis against the growth of gram-negative (E.coli, P. aeruginosa) and gram-positive (S. aureus) strains. The antimicrobial activity of the dressing against microbial pathogens on the wound surface was demonstrated in in vivo experiments on male rats. The dressing was also tested on volunteer patients. The testing showed reduction of the wound healing period, accelerated cleaning of the infected wound and enhanced tissue regeneration in the wound. The results demonstrate that the VitaVallis dressing can be used for the treatment of deep infected wounds.

  9. Application of VitaVallis dressing for infected wounds

    SciTech Connect

    Kirilova, N. V. Fomenko, A. N. Korovin, M. S.

    2015-11-17

    Today there is a growing demand for safe and efficient antimicrobial dressings for infected wound treatment. The antimicrobial sorption material for VitaVallis dressings was produced by one-stage oxidation of aluminum nanopowder in water in the presence of fibrous acetylcellulose matrix. Scanning electron microscopy revealed that the material is made up of fibers of diameter 1.5–3.0 µm with adhered agglomerated alumina nanosheets. An antimicrobial study revealed a high inhibitory effect of VitaVallis against the growth of gram-negative (E.coli, P. aeruginosa) and gram-positive (S. aureus) strains. The antimicrobial activity of the dressing against microbial pathogens on the wound surface was demonstrated in in vivo experiments on male rats. The dressing was also tested on volunteer patients. The testing showed reduction of the wound healing period, accelerated cleaning of the infected wound and enhanced tissue regeneration in the wound. The results demonstrate that the VitaVallis dressing can be used for the treatment of deep infected wounds.

  10. Dementia with Lewy bodies

    PubMed Central

    Ferman, Tanis J.; Boeve, Bradley F.

    2009-01-01

    Synopsis The advent of new immunostains have improved our ability to detect limbic and cortical Lewy bodies, and it is now evident that Dementa with Lewy bodies (DLB) is the second most common neurodegenerative dementia, after Alzheimer’s disease (AD). Distinguishing DLB from AD has important implications for treatment, in terms of substances that may worsen symptoms (i.e., anticholinergic and certain neuroleptic medications) and those that may improve them (i.e., cholinesterase inhibitors, carbidopa-levodopa). Neurocognitive patterns, psychiatric features, extrapyramidal signs and sleep disturbance are helpful in differentiating DLB from AD early in the disease course. Differences in the severity of cholinergic depletion as well as type and distribution of neuropathology contribute to these clinical differences, though DLB patients with a high density of co-occuring AD pathology are less clinical distinguishable from AD. PMID:17659188

  11. Edwin W. Lewis, Jr.

    NASA Technical Reports Server (NTRS)

    1999-01-01

    Edwin W. Lewis Jr. is a research pilot in the Airborne Science program, Flight Crew Branch, Dryden Flight Research Center, Edwards, California. He currently flies the DC-8, F/A-18, Lear Jet 24, King Air, and T-34C in support of Dryden's flight operations and is mentor pilot for the King Air and the Lear Jet. Prior to accepting this assignment Lewis was a pilot for eight years at NASA's Ames Research Center, Moffett Field, California, flying 10 different aircraft - C-130B, DC-8-72, UH-1, SH-3, King Air, Lear 24, T-38A, T-39G and YO-3A - in support of NASA flight missions. Lewis also flew the Kuiper Airborne Observatory (a modified civilian version of the Lockheed C-141 Starlifter). He was project pilot for Ames' 747 and T-38 programs. Lewis was born in New York City on May 19, 1936, and began flight training as a Civil Air Patrol cadet in 1951, ultimately earning his commercial pilot's certificate in 1958. He received a bachelor of arts degree in biology from Hobart College, Geneva, N.Y., and entered the U.S. Air Force through the Reserve Officer Training Corps. Following pilot training he was assigned to Moody Air Force Base, Ga., as an instructor pilot, for both the T-33 and T-37 aircraft. He served in Vietnam in 1965 and 1966, where he was a forward air controller, instructor and standardization/evaluation pilot, flying more than 1,000 hours in the O-1 'Bird Dog.' Lewis separated from the regular Air Force and joined Pan American World Airways and the 129th Air Commando Group, California Air National Guard (ANG) based in Hayward, California. During his 18-year career with the California ANG he flew the U-6, U-10, C-119, HC-130 aircraft and the HH-3 helicopter. He retired as commander, 129th Air Rescue and Recovery Group, a composite combat rescue group, in the grade of colonel. During his 22 years as an airline pilot, he flew the Boeing 707, 727 and 747. He took early retirement from Pan American in 1989 to become a pilot with NASA.

  12. A balancing act: the curriculum vitae and the interview process.

    PubMed

    Lloyd, B A; Dickson, C J

    1994-01-01

    The authors believe that one possible solution to the dearth of minority nursing faculty in higher education is thorough preparation for the search process by the minority applicant. This article discusses the appointment/hiring process and provides the reader with authoritative and experiential information necessary for constructing a curriculum vitae (CV) and preparing for an interview. Armed with a proper CV and knowledge of potential interview questions, the authors believe that minority applicants will be able to maneuver their way through the maize of job interviews. In addition, suggestions are offered to those serving on promotion and tenure committees and administrators.

  13. The Curriculum Vitae--What It Is and What It Is Not.

    ERIC Educational Resources Information Center

    Newcomb, B. Joan; Murphy, Patricia A.

    1979-01-01

    Presents guidelines to nurses for preparing curriculum vitae, narrower and more stylized than resumes, which outline qualifications for academic positions, committees, and honors. Lists categories and describes content of information to be included on a vita (a sample is shown) and notes what to avoid. (MF)

  14. Dementia with Lewy bodies.

    PubMed

    McKeith, Ian G; Burn, David J; Ballard, Clive G; Collerton, Daniel; Jaros, Evelyn; Morris, Chris M; McLaren, Andrew; Perry, Elaine K; Perry, Robert; Piggott, Margaret A; O'Brien, John T

    2003-01-01

    The objective was to summarize recent findings about the clinical features, diagnosis and investigation of dementia with Lewy (DLB) bodies, together with its neuropathology, neurochemistry and genetics. Dementia with Lewy bodies (DLB) is a primary, neurodegenerative dementia sharing clinical and pathological characteristics with both Parkinson's disease (PD) and Alzheimer's disease (AD). Antiubiquitin immunocytochemical staining, developed in the early 1990s, allowed the frequency and distribution of cortical LBs to be defined. More recently, alpha-synuclein antibodies have revealed extensive neuritic pathology in DLB demonstrating a neurobiological link with other "synucleinopathies" including PD and multiple system atrophy (MSA). The most significant correlates of cognitive failure in DLB appear to be with cortical LB and Lewy neurites (LNs) rather than Alzheimer type pathology. Clinical diagnostic criteria for DLB, published in 1996, have been subjected to several validation studies against autopsy findings. These conclude that although diagnostic specificity is high (range 79- 100%, mean 92%), sensitivity is lower (range 0- 83 %, mean, 49%). Improved methods of case detection are therefore required. Fluctuating impairments in attention, visual recognition and construction are more indicative of DLB than AD. Relative preservation of medial temporal lobe volume on structural MRI and the use of SPECT tracers for regional blood flow and the dopamine transporter are the most reliable current biomarkers for DLB. There are no genetic or CSF tests recommended for the diagnosis of DLB at present. Between 15 and 20% of all elderly demented cases reaching autopsy have DLB, making it the most common cause of degenerative dementia after AD. Exquisite, not infrequently fatal, sensitivity to neuroleptic drugs and encouraging reports of the effects of cholinesterase inhibitors on cognitive, psychiatric and neurological features, mean that an accurate diagnosis of DLB is more

  15. [Anesthesiological systems "Polinarkon-Vita" with microprocessor for artificial lung ventilation apparatuses and monitoring].

    PubMed

    Trushin, A I; Uliakov, G I; Reĭderman, E N

    2005-01-01

    The anesthesiological systems Polinarkon-Vita for adults and children are described. These systems were developed at VNIIMP-VITA, Ltd. on the basis of basic model of the anesthesiological system Polinarkon-E-Vita. The following new important units of the fifth generation apparatuses for inhalation anesthesia (IA) are described: Anestezist-4 monocomponent evaporator for liquid anesthetics (enfluran and isofluran); Diana, Diana-Det, and Elan-NR apparatuses for mechanical lung ventilation (MLV); dosimeters of medical gases, etc. These systems implement monitoring of vitally important functions of patient and parameters of IN and MLV. The anesthesiological systems Polinarkon-Vita are recommended for medical practice and commercially available from VNIIMP-VITA, Ltd. as small lots.

  16. Creating Curriculum Vitae for Understanding People on the Web

    NASA Astrophysics Data System (ADS)

    Ueda, Hiroshi; Murakami, Harumi; Tatsumi, Shoji

    When users find information about people from the results of Web people searches, they often need to browse many obtained Web pages and check much unnecessary information. This task is time-consuming and complicates the understanding of the designated people. We investigate a method that integrates the useful information obtained from Web pages and displays them to understand people. We focus on curriculum vitae, which are widely used for understanding people. We propose a method that extracts event sentences from Web pages and displays them like a curriculum vita. The event sentence includes both time and events related to a person. Our method is based on the following: (1) extracting event sentences using heuristics and filtering them, (2) judging whether event sentences are related to a designated person by mainly using the patterns of HTML tags, (3) classifying these sentences to categories by SVM, and (4) clustering event sentences including both identical times and events. Experimental results revealed the usefulness of our proposed method.

  17. Lewis base activation of Lewis acids: development of a Lewis base catalyzed selenolactonization.

    PubMed

    Denmark, Scott E; Collins, William R

    2007-09-13

    The concept of Lewis base activation of Lewis acids has been applied to the selenolactonization reaction. Through the use of substoichiometric amounts of Lewis bases with "soft" donor atoms (S, Se, P) significant rate enhancements over the background reaction are seen. Preliminary mechanistic investigations have revealed the resting state of the catalyst as well as the significance of a weak Brønsted acid promoter.

  18. Lewis Incubator for Technology (LIFT)

    NASA Technical Reports Server (NTRS)

    Zeman, Wayne P.; King, Joseph B.; Jankura, Richard E., Jr.

    2004-01-01

    This report summarizes the work done to operate the Lewis Incubator for Technology for the period October 2000 through September 2004. The Lewis Incubator helped the startup and growth of technology based businesses with the potential to incorporate technology from the NASA Glenn Research Center.

  19. Meriwether Lewis: Was it Suicide?

    ERIC Educational Resources Information Center

    Westefeld, John S.; Less, Aaron

    2004-01-01

    Even 200 years following the conclusion of the Lewis and Clark Expedition, questions remain about whether Meriwether Lewis' death was a suicide. The purpose of this article is to consider this issue by examining historical evidence from a psychological perspective. A risk factor model for suicide assessment (Sanchez, 2001) is employed to evaluate…

  20. Rep. Bill Nelson during space food and consumables orientation and suit fitting

    NASA Technical Reports Server (NTRS)

    1987-01-01

    Rita Rapp, a flight coordinator, briefs U.S. Rep. Bill Nelson (D.-Florida) on space food during an orientation session in the life sciences laboratory at JSC (27753); Rep. Nelson tries on a glove during a suit fitting session (27754); Rep. Nelson samples a package of re-hydratable fruit in the life sciences laboratory during early STS 61-C training (27755); Rep. Nelson listens to Laura Louviere brief him on hygiene articles soon after reporting to Houston for STS 61-C training. On the table in front of him is a tube marked Palmalive, a tube marked Gillette and various other articles (27756).

  1. Failure Analysis of Main Flame Deflector Nelson Studs

    NASA Technical Reports Server (NTRS)

    Long, Victoria

    2009-01-01

    NASA Structures engineers submitted two Nelson refractory studs from the main flame deflector at Launch Complex (LC) 39 A for analysis when they were observed to be missing a significant amount of material after launch. The damaged stud and an unused comparative stud were analyzed by macroscopic and microscopic examination along with metallographic evaluation of the microstructure. The stud lost material due to a combination of erosion and corrosion. Plain carbon steel readily forms an oxide layer in the coastal launch environment at Kennedy Space Center. The blast during a launch removes this brittle oxide layer, which then forms again post-launch, thereby further removing material. No indications of melting were observed.

  2. 77 FR 42327 - Proposed Supplementary Rules for the Morley Nelson Snake River Birds of Prey National...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-07-18

    ... Bureau of Land Management Proposed Supplementary Rules for the Morley Nelson Snake River Birds of Prey...-administered public lands within the approximately 483,700-acre Morley Nelson Snake River Birds of Prey... of Decision (ROD). The Snake River Birds of Prey NCA RMP identifies implementation level...

  3. An interview with Lewis Wolpert.

    PubMed

    Wolpert, Lewis; Vicente, Catarina

    2015-08-01

    Lewis Wolpert is a retired developmental biologist who, over his long career, has made many important contributions to the field, from his French Flag model and the concept of positional information to the famous quote that it is "not birth, marriage or death, but gastrulation which is truly the most important time in your life." In addition to his scientific contributions, Lewis is also a prolific writer, from the textbook 'Developmental Biology' to books about popular science, religion and his battle with depression. Although born in South Africa, it was in the United Kingdom that Lewis spent most of his scientific career. We met Lewis at the Spring Meeting of the British Society for Developmental Biology, where he was awarded the Waddington Medal.

  4. Impact resistance of oil-immersed lignum vitae.

    PubMed

    Yin, Wei; Shan, Lei; Lu, Hongyu; Zheng, Yelong; Han, Zhiwu; Tian, Yu

    2016-07-18

    Biological materials immersed in vegetable and mineral oil, such as rattan armor and wooden sleepers, have been extensively used since ancient times because of their excellent mechanical properties. This study quantitatively investigated the viscoelasticity and tribological performance of lignum vitae immersed in poly-alpha-olefin (PAO) and tung oils (Aleuritesfordii Hemsl.) to reveal the mechanism of impact resistance. The acceleration of samples immersed in tung oil was higher than that of dry and PAO-immersed samples in the first impact. The elastic modulus of the samples immersed in tung oil increased slightly. The impact damage on the samples immersed in tung oil was reduced because of the low friction coefficient (0.07) resulted in a low wear rate. The extent of impact damage on the samples immersed in tung oil was approximately 34% and 58% lower than that on the dry and PAO oil-immersed samples, respectively, under an angle of 20° and a height of 10 cm. The impact damage on the PAO-immersed samples was reduced because of low friction coefficient. However, impact damage increased because of large elastic modulus. The findings of this study can serve as a reference for the application of modified biological materials with high strength and wear resistance.

  5. Preparing a successful, role-specific curriculum vitae.

    PubMed

    Price, Bob

    2014-10-07

    An internet search reveals just how many articles there are on preparing a curriculum vitae (CV). The preparation of a CV should not be regarded as a 'one-off' event, to be updated periodically. A successful CV requires thoughtful preparation to ensure it is directed towards a specific post and should consider two important perspectives. First, an understanding of what is required of the practitioner in the nursing post (demand), and second, what the nurse can offer in terms of his or her skills, experience, qualities and qualifications (supply). The demands of the post will also include meeting professional standards, such as those that have emerged following consideration of the Report of the Mid Staffordshire NHS Foundation Trust Public Inquiry (Francis 2013). This article explores how to prepare a successful CV for a specific role, using a demand and supply perspective--where a nurse seeks to match the specific requirements of the post by summarising what he or she has to offer.

  6. Impact resistance of oil-immersed lignum vitae

    NASA Astrophysics Data System (ADS)

    Yin, Wei; Shan, Lei; Lu, Hongyu; Zheng, Yelong; Han, Zhiwu; Tian, Yu

    2016-07-01

    Biological materials immersed in vegetable and mineral oil, such as rattan armor and wooden sleepers, have been extensively used since ancient times because of their excellent mechanical properties. This study quantitatively investigated the viscoelasticity and tribological performance of lignum vitae immersed in poly-alpha-olefin (PAO) and tung oils (Aleuritesfordii Hemsl.) to reveal the mechanism of impact resistance. The acceleration of samples immersed in tung oil was higher than that of dry and PAO-immersed samples in the first impact. The elastic modulus of the samples immersed in tung oil increased slightly. The impact damage on the samples immersed in tung oil was reduced because of the low friction coefficient (0.07) resulted in a low wear rate. The extent of impact damage on the samples immersed in tung oil was approximately 34% and 58% lower than that on the dry and PAO oil-immersed samples, respectively, under an angle of 20° and a height of 10 cm. The impact damage on the PAO-immersed samples was reduced because of low friction coefficient. However, impact damage increased because of large elastic modulus. The findings of this study can serve as a reference for the application of modified biological materials with high strength and wear resistance.

  7. Impact resistance of oil-immersed lignum vitae

    PubMed Central

    Yin, Wei; Shan, Lei; Lu, Hongyu; Zheng, Yelong; Han, Zhiwu; Tian, Yu

    2016-01-01

    Biological materials immersed in vegetable and mineral oil, such as rattan armor and wooden sleepers, have been extensively used since ancient times because of their excellent mechanical properties. This study quantitatively investigated the viscoelasticity and tribological performance of lignum vitae immersed in poly-alpha-olefin (PAO) and tung oils (Aleuritesfordii Hemsl.) to reveal the mechanism of impact resistance. The acceleration of samples immersed in tung oil was higher than that of dry and PAO-immersed samples in the first impact. The elastic modulus of the samples immersed in tung oil increased slightly. The impact damage on the samples immersed in tung oil was reduced because of the low friction coefficient (0.07) resulted in a low wear rate. The extent of impact damage on the samples immersed in tung oil was approximately 34% and 58% lower than that on the dry and PAO oil-immersed samples, respectively, under an angle of 20° and a height of 10 cm. The impact damage on the PAO-immersed samples was reduced because of low friction coefficient. However, impact damage increased because of large elastic modulus. The findings of this study can serve as a reference for the application of modified biological materials with high strength and wear resistance. PMID:27425829

  8. Placement Testing in Community Colleges: A Response to Hughes and Nelson.

    ERIC Educational Resources Information Center

    Gillespie, Maggie

    1993-01-01

    Analyzes Hughes and Nelson's study of placement testing at Riverside Community College and offers an alternative method of evaluating placement systems using logistic regression. Reanalyzes data from an ASSET placement test validity study using logistic regression. (DMM)

  9. New synchronous compensators for the Nelson River HVDC system; Planning requirements and specifications

    SciTech Connect

    Thio, C.V.; Davies, J.B. )

    1991-04-01

    The first units of Limestone Generating Station, the third plant on the Lower Nelson River in northern Manitoba, will come into service in the fall of 1990. Additional var compensation equipment is required at the inverter end of the Nelson River HVdc system to accommodate power from Limestone. This paper describes the system requirements of and the overall specification for the synchronous compensators selected to supply the reactive power and voltage support.

  10. Conservative Diffusions: a Constructive Approach to Nelson's Stochastic Mechanics.

    NASA Astrophysics Data System (ADS)

    Carlen, Eric Anders

    In Nelson's stochastic mechanics, quantum phenomena are described in terms of diffusions instead of wave functions; this thesis is a study of that description. We emphasize that we are concerned here with the possibility of describing, as opposed to explaining, quantum phenomena in terms of diffusions. In this direction, the following questions arise: "Do the diffusions of stochastic mechanics--which are formally given by stochastic differential equations with extremely singular coefficients--really exist?" Given that they exist, one can ask, "Do these diffusions have physically reasonable sample path behavior, and can we use information about sample paths to study the behavior of physical systems?" These are the questions we treat in this thesis. In Chapter I we review stochastic mechanics and diffusion theory, using the Guerra-Morato variational principle to establish the connection with the Schroedinger equation. This chapter is largely expository; however, there are some novel features and proofs. In Chapter II we settle the first of the questions raised above. Using PDE methods, we construct the diffusions of stochastic mechanics. Our result is sufficiently general to be of independent mathematical interest. In Chapter III we treat potential scattering in stochastic mechanics and discuss direct probabilistic methods of studying quantum scattering problems. Our results provide a solid "Yes" in answer to the second question raised above.

  11. Lewis & Clark: An Interdisciplinary Expedition

    ERIC Educational Resources Information Center

    Brugar, Kristy

    2004-01-01

    On January 18, 1803 President Thomas Jefferson asked Congress to fund an expedition to the source of the Missouri River. This expedition would become known as the Corps of Discovery, which would spend twenty-eight months exploring, studying, and documenting the wonders of the western frontier. Led by Captains Meriwether Lewis and William Clark,…

  12. Lewis and Clark as Naturalists.

    ERIC Educational Resources Information Center

    Smithsonian Institution, Washington, DC. National Museum of Natural History.

    Intended for use in elementary and high school education, this Web site includes a teacher's guide and three lesson plans. The site contains images of museum specimens, scientific drawings, and field photos of the plant and animal species observed by Meriwether Lewis and William Clark, along with journal excerpts, historical notes, and references…

  13. Action Learning in John Lewis

    ERIC Educational Resources Information Center

    Spencer, Chris

    2005-01-01

    A small group of training professionals within the John Lewis Partnership set up an action learning group about 2 years ago. The main aim was to explore the technique for our own learning and development. The timing and lifespan of the group reflected the generally strategic and long-term nature of our projects. One of these was to introduce…

  14. Assessment of color fidelity of several composite resins compared to their Vita Classical shade registration.

    PubMed

    Barcellos, Daphne Camara; Torres, Carlos Rocha Gomes; Pucci, Cesar Rogerio; Borges, Alessandra Buhler; Goncalves, Sergio Eduardo de Paiva; Limeira, Renata; Souza, Dayane

    2010-01-01

    This study compared the color fidelity of different composite resins with their registration in the Vita Classical Shade Guide. Using a prefabricated Teflon mold, 120 specimens were divided into four groups (n = 30), according to the resin tested. Three subgroups (n = 10) were prepared for each resin group; these subgroups tested enamel shade, dentin shade, and enamel and dentin shade. Three measurements were performed to verify whether the tooth shade matched that of the Vita Classical Shade Guide. The color was evaluated and the shade variations were calculated. The data were submitted to a three-way ANOVA test (time, color match, and composite type), followed by Tukey's test. It was concluded that all composite resins showed color differences in relation to the Vita Classical Shade Guide.

  15. Antimicrobial Potential and Chemical Characterization of Serbian Liverwort (Porella arboris-vitae): SEM and TEM Observations.

    PubMed

    Kumar Tyagi, Amit; Bukvicki, Danka; Gottardi, Davide; Veljic, Milan; Guerzoni, Maria Elisabetta; Malik, Anushree; Marin, Petar D

    2013-01-01

    The chemical composition of Porella arboris-vitae extracts was determined by solid phase microextraction, gas chromatography-mass spectrometry (SPME GC-MS), and 66 constituents were identified. The dominant compounds in methanol extract of P. arboris-vitae were β-caryophyllene (14.7%), α-gurjunene (10.9%), α-selinene (10.8%), β-elemene (5.6%), γ-muurolene (4.6%), and allo-aromadendrene (4.3%) and in ethanol extract, β-caryophyllene (11.8%), α-selinene (9.6%), α-gurjunene (9.4%), isopentyl alcohol (8.8%), 2-hexanol (3.7%), β-elemene (3.7%), allo-aromadendrene (3.7%), and γ-muurolene (3.3%) were the major components. In ethyl acetate extract of P. arboris-vitae, undecane (11.3%), β-caryophyllene (8.4%), dodecane (6.4%), α-gurjunene (6%), 2-methyldecane (5.1%), hemimellitene (4.9%), and D-limonene (3.9%) were major components. The antimicrobial activity of different P. arboris-vitae extracts was evaluated against selected food spoilage microorganisms using microbroth dilution method. The Minimal Inhibitory Concentration (MIC) varied from 0.5 to 1.5 mg/mL and 1.25 to 2 mg/mL for yeast and bacterial strains, respectively. Significant morphological and ultrastructural alterations due to the effect of methanolic and ethanolic P. arboris-vitae extracts on S. Enteritidis have also been observed by scanning electron microscope and transmission electron microscope, respectively. The results provide the evidence of antimicrobial potential of P. arboris-vitae extracts and suggest its potential as natural antimicrobial agents for food preservation.

  16. A New Work Sample Battery for Vocational Assessment of the Disadvantaged: VITAS.

    ERIC Educational Resources Information Center

    Abrams, Michael

    1979-01-01

    Describes the development of a work sample battery designed for assessment of vocational aptitudes, interests, and temperament in a disadvantaged client population. VITAS provides information about factors most related to success on the job: interest in the job, temperament for the job, and aptitudes for physical and cognitive components of the…

  17. The Vita Activa as Compass: Navigating Uncertainty in Teaching with Hannah Arendt

    ERIC Educational Resources Information Center

    Rogers, Carrie Ann Barnes

    2010-01-01

    This dissertation is an exploration of stories of uncertainty in the lives of elementary teachers and the value that the ideas of Hannah Arendt lend to the discussion around uncertainty. In "The Human Condition" (1958) Hannah Arendt theorizes the life of action, the "vita activa". Arendtian action is inherently uncertain because to be "capable of…

  18. 77 FR 6863 - Proposed Collection; Comment Request for VITA/TCE Program Forms

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-02-09

    ... Internal Revenue Service offers free assistance with tax return preparation and tax counseling using specially trained volunteers. The Volunteer Income Tax Assistance (VITA) and Tax Counseling for the Elderly... through the use of automated collection techniques or other forms of information technology; and...

  19. Structural and redox behavior of OxyVita, a zero-linked polymeric hemoglobin: comparison with natural acellular polymeric hemoglobins.

    PubMed

    Harrington, John P; Orlik, Kseniya; Orlig, Kseniya; Zito, Samantha L; Wollocko, Jacek; Wollocko, Hanna

    2010-04-01

    A zero-linked polymeric hemoglobin (OxyVita Hb) has been developed for application as an acellular therapeutic hemoglobin-based-oxygen-carrier (HBOC). For effective and safe oxygen binding, transport and delivery, an HBOC must meet essential molecular requirements related to its structural integrity and redox stability. OxyVita is a super polymer possessing an average M.wt. of 17 x 10(6) Da. Structural integrity was determined by unfolding studies of OxyVita in the presence of increasing concentrations of urea. The unfolding midpoints (D(1/2)) of different preparations of OxyVita (solution and powder forms) were compared to Lumbricus Hb (LtHb) and Arenicola Hb (ArHb), natural acellular polymeric hemoglobins, which are serving as models for an effective and safe acellular HBOC. Reduction studies of OxyVita Hb using endogenous reducing agents were also investigated. Results from these studies indicate that: 1) OxyVita Hb exhibits greater resistance to conformational change than either LtHb or ArHb in the reduced (oxyHb) state; and 2) the reduction of met OxyVita Hb to oxyHb occurs slowly in the presence of either ascorbic acid (70% reduction in 560 min.) or beta-NADH (40% reduction in 90 min.). These studies provide consistent evidence that OxyVita Hb possesses physiochemical properties that exhibit structural integrity and redox behavior necessary for functioning as an effective and safe HBOC within clinical applications. These results are in agreement with observations made by other investigators as to the reduction in heme-loss of OxyVita Hb, essential for the reversible binding/release of molecular oxygen within the circulatory system.

  20. STS-26 MS Nelson during Crew escape system (CES) testing in JSC WETF Bldg 29

    NASA Technical Reports Server (NTRS)

    1988-01-01

    STS-26 Discovery, Orbiter Vehicle (OV) 103, Mission Specialist (MS) George D. Nelson participates in crew escape system (CES) testing in JSC Weightless Environment Training Facility (WETF) Bldg 29. Nelson, wearing the newly designed (navy blue) launch and entry suit (LES), floats in WETF pool with the aid of an underarm flotation device (modern version of Mas West floats). He awaits the assistance of SCUBA-equipped divers during a simulation of escape and rescue operations utilizing a new CES pole for emergency exit from the Space Shuttle.

  1. STS-26 MS Nelson during Crew Escape System (CES) testing in JSC WETF Bldg 29

    NASA Technical Reports Server (NTRS)

    1988-01-01

    STS-26 Discovery, Orbiter Vehicle (OV) 103, Mission Specialist (MS) George D. Nelson participates in crew escape system (CES) testing in JSC Weightless Environment Training Facility (WETF) Bldg 29. With helmet visor down, Nelson, wearing the newly designed (navy blue) launch and entry suit (LES), floats in WETF pool with the aid of an underarm flotation device (modern version of Mae West floats). He awaits the assistance of SCUBA-equipped divers during a simulation of escape and rescue operations utilizing a new CES pole for emergency exit from the Space Shuttle.

  2. Modifications to Ivor Lewis esophagectomy.

    PubMed

    David, Elizabeth A; Marshall, M Blair

    2010-11-01

    The surgical approach to esophagectomy is variable. A number of factors are considered when determining the optimal approach to esophagectomy: location and extent of disease, fibrosis, additional patient factors and surgeon preference. One of the disadvantages to some approaches is the need for a change in position, which increases operative time. Also, because typically the abdomen is initially explored, patients may later be deemed unresectable at thoracotomy. We describe time saving modifications to the standard Ivor Lewis esophagectomy that eliminate the need for repositioning and facilitate a stapled end-to-end anastomosis.

  3. 78 FR 66353 - EAM Nelson Holdings, LLC; Supplemental Notice That Initial Market-Based Rate Filing Includes...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-11-05

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF ENERGY Federal Energy Regulatory Commission EAM Nelson Holdings, LLC; Supplemental Notice That Initial Market-Based Rate...-referenced proceeding, of EAM Nelson Holdings, LLC's application for market-based rate authority, with...

  4. 76 FR 56455 - DaVita, Inc.; Analysis of Agreement Containing Consent Orders To Aid Public Comment

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-09-13

    ... three times per week in sessions lasting between three and five hours. Kidney transplantation is the... of DaVita and DSI's head-to-head competition in these markets, indicates that the combined firm...

  5. Fort Lewis Exceptional Family Member Program (EFMP)

    ERIC Educational Resources Information Center

    Hebdon, Heather

    2007-01-01

    Located in the shadow of Mt. Rainier, Fort Lewis is the home of the highest per capita exceptional family member population in the Army. Ideally located on the Northwest coast of Washington State, Fort Lewis is home to the Strykers and First Brigade. Combined with its close proximity to McChord Air Force Base, the installation is ideally suited to…

  6. Simplified Lewis Structure Drawing for Nonscience Majors.

    ERIC Educational Resources Information Center

    Miburo, Barnabe B.

    1998-01-01

    Argues that Lewis diagrams can be easily done by students using a minimal number of clues. Presents a method to draw the Lewis structure of molecules, polyatomic ions, and radicals whereby students no longer need to move bonds or lone pairs of electrons. (DDR)

  7. "Finding Useful Questions: On Bayesian Diagnosticity, Probability, Impact, and Information Gain": Correction to Nelson (2005)

    ERIC Educational Resources Information Center

    Nelson, Jonathan D.

    2007-01-01

    Reports an error in "Finding Useful Questions: On Bayesian Diagnosticity, Probability, Impact, and Information Gain" by Jonathan D. Nelson (Psychological Review, 2005[Oct], Vol 112[4], 979-999). In Table 13, the data should indicate that 7% of females had short hair and 93% of females had long hair. The calculations and discussion in the article…

  8. Radical Questioning on the Long Walk to Freedom: Nelson Mandela and the Practice of Critical Reflection

    ERIC Educational Resources Information Center

    Brookfield, Stephen

    2008-01-01

    Nelson Mandela's autobiography "The Long Walk to Freedom" describes how an iconic political activist and freedom fighter reflected on, and sometimes modified, four core assumptions at the heart of his struggle to overturn the White supremacist, minority hegemony and create a free South Africa. Critical reflection's focus is on…

  9. 78 FR 56224 - Hydro Nelson, Ltd.; Hydro-WM, LLC; Notice of Transfer of Exemption

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-09-12

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF ENERGY Federal Energy Regulatory Commission Hydro Nelson, Ltd.; Hydro-WM, LLC; Notice of Transfer of Exemption 1. By documentation filed July 8, 2013 and supplemented on September 4, 2013, Hydro-WM, LLC informed the...

  10. "Passageless" Administration of the Nelson-Denny Reading Comprehension Test: Associations with IQ and Reading Skills

    ERIC Educational Resources Information Center

    Ready, Rebecca E.; Chaudhry, Maheen F.; Schatz, Kelly C.; Strazzullo, Sarah

    2013-01-01

    There are few tests that assess reading comprehension in adults, but these tests are needed for a comprehensive assessment of reading disorders (RD). "The Nelson-Denny Reading Test" (NDRT) has a long-passage reading comprehension component that can be used with adolescents and adults. A problem with the NDRT is that reading comprehension…

  11. Part of the Solution: Judy Nelson--Pierce County Library System, Tacoma

    ERIC Educational Resources Information Center

    Library Journal, 2005

    2005-01-01

    Judy Nelson thinks it's important to understand what the community wants for its young people, "which means lots of listening." We need to give taxpayers more good reasons to support libraries, she says, and the community's problems and unmet needs are opportunities for libraries to be an integral part of the solution. One problem Nelson…

  12. U.S. Rep. William Nelson drinking tea from shuttle beverage container

    NASA Technical Reports Server (NTRS)

    1985-01-01

    U.S. Rep. William Nelson of Florida tries drinking tea from a straw-equipped beverage dispenser in JSC's life sciences laboratory during a space food orientation session. The congressman is in early stages of training for a position on the STS 61-C mission.

  13. Adult Learners: New Norms on the Nelson-Denny Reading Test for Healthcare Professionals.

    ERIC Educational Resources Information Center

    Haught, Patricia A.; Walls, Richard T.

    2002-01-01

    Presents new norms on the Nelson-Denny Reading Test for healthcare-professional students. Notes that it is generally accepted that professional and graduate schools require students with good reading ability because of the quantity of material to be read. Presents standard scores, percentile ranks, and stanine scores as revised norms based on test…

  14. Coherent Backscattering: Conceptions and Misconceptions (Reply to Comments by Bruce W. Hapke and Robert M. Nelson)

    NASA Technical Reports Server (NTRS)

    Tishkovets, Victor P.; Mishchenko, Michael

    2010-01-01

    Although the note by Hapke and Nelson has virtually no relevance to our original publication, it contains a number of statements that are misleading and/or wrong. We, therefore, use this opportunity to dispel several profound misconceptions that continue to hinder the progress in remote sensing of planetary surfaces.

  15. 3 CFR 9067 - Proclamation 9067 of December 5, 2013. Death of Nelson Mandela

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ..., and the world has lost an inspiration for freedom, justice, and human dignity—Nelson Mandela is no... President embodied the promise that human beings—and countries—can change for the better. His commitment to... friend and partner of the United States. And his memory will be kept in the hearts of billions who...

  16. Celebrating the Hero in All of Us: An Interview with Kadir Nelson

    ERIC Educational Resources Information Center

    Sableski, Mary-Kate; Arnold, Jackie Marshall; Adomat, Donna Sayers

    2015-01-01

    Books provide an opportunity through which children can learn what it means to be in the world and to respond flexibly and creatively to a diverse range of situations. Author/illustrator Kadir Nelson creates books that provide these opportunities for readers of all ages. A dominant theme in current conversations surrounding children's literature…

  17. Shaping Influences on the Leadership of Genghis Khan, George Washington, and Nelson Mandela: Applications for Educators

    ERIC Educational Resources Information Center

    Bongila, Jean-Pierre

    2011-01-01

    Using a prosopographical methodology this study examines common leadership influences that might have existed among Genghis Khan, George Washington, and Nelson Mandela. Shoup (2005) suggests that the following seven influences have contributed to nurturing the leadership of 12 renowned individuals: involved parents, happy childhood, formal,…

  18. UK Data from 197 Undergraduates for the Nelson Denny Reading Test

    ERIC Educational Resources Information Center

    Masterson, Jackie; Hayes, Maureen

    2004-01-01

    The Nelson Denny Reading Test (Brown, Fishco & Hanna, 1993) provides measures of comprehension, reading rate and vocabulary. It is widely used in research studies with high school and undergraduate students and for assessment purposes in the USA. No widely used test of this kind exists for adults in the UK. The present paper reports data from 197…

  19. Social Justice and Human Rights in Education Policy Discourse: Assessing Nelson Mandela's Legacy

    ERIC Educational Resources Information Center

    Gebremedhin, Abrehet; Joshi, Devin

    2016-01-01

    Twenty years after South Africa's democratisation, Nelson Mandela's passing has prompted scholars to examine his legacy in various domains. Here we take a look at his legacy in education discourse. Tracing Mandela's thoughts and pronouncements on education we find two major emphases: a view of education as a practical means to economic…

  20. Effective Design and Evaluation of Serious Games: The Case of the e-VITA Project

    NASA Astrophysics Data System (ADS)

    Pappa, Dimitra; Pannese, Lucia

    Learning and training are presently facing new challenges and a strong transformation. The use of electronic games for education (game-based learning) promotes an agile, immersive and stimulating form of learning that fosters learner engagement and motivation. Nonetheless, the design of effective and engaging educational games is a creative process that is unique to each situation. This paper discusses the inherent challenges of building intellectually appropriate and engaging games and presents the methodology adopted in the case of the e-VITA project that applies GBL to promote knowledge sharing and transfer for intergenerational learning. The paper analyses the e-VITAframework for SGs evaluation, which is central to the project's iterative development approach. Early findings stemming from the validation of the e-VITA prototype game are also presented.

  1. Importance of components of the curriculum vitae in determining appointment to senior registrar posts.

    PubMed

    Conn, D A; Asbury, A J

    1994-07-01

    To evaluate the opinions of regional education advisers, academics and other consultants about features of the curriculum vitae, we undertook a small attitude survey. The response rate was 73%, which provided data from a total of 78 influential anaesthetists. The respondents' attitude to each feature of the curriculum vitae was reported using a linear visual analogue scale. The three groups had similar attitude scores to most features, but not to research time, training time, higher degrees and abstracts of papers presented to the Anaesthetic Research Society. Publications in the main anaesthesia journals, time in other major medical specialties, research and the possession of a higher degree were scored highly by all respondents. Papers in non-peer-reviewed journals, letters, unsubmitted papers, and time in training for general practice attracted lower scores. The free text comments of many respondents indicated a considerable disillusionment about the whole appointments process.

  2. Human noroviruses recognize sialyl Lewis x neoglycoprotein.

    PubMed

    Rydell, Gustaf E; Nilsson, Jonas; Rodriguez-Diaz, Jesus; Ruvoën-Clouet, Nathalie; Svensson, Lennart; Le Pendu, Jacques; Larson, Göran

    2009-03-01

    The carbohydrate binding characteristics of a norovirus GII.3 (Chron1) and a GII.4 (Dijon) strain were investigated using virus-like particles (VLPs) and saliva samples from 81 individuals genotyped for FUT2 (secretor) and FUT3 (Lewis) and phenotyped for ABO and Lewis blood groups. The two VLPs showed a typical secretor-gene-dependent binding and bound significantly stronger to saliva from A, B, and AB than from O individuals (P < 0.0001 and P < 0.001) but did not bind to any samples from secretor-negative individuals. The GII.3 strain showed larger interindividual variation and bound stronger to saliva from B than from A(2) secretors (P < 0.01). When assaying for binding to neoglycoproteins, the GII.3 and GII.4 strains were compared with the Norwalk GI.1 prototype strain. Although all three strains bound to Lewis b (and H type 1 chain) glycoconjugates, only the two GII strains showed an additional binding to sialyl Lewis x. This novel binding was specific since the VLPs did not bind to structural analogs, e.g., Lewis x or sialyl Lewis a, but only to sialyl Lewis x, sialyl diLewis x and sialylated type 2 chain conjugates. In inhibition experiments, the sialyl Lewis x conjugate was the most potent inhibitor. The minimal requirement for this potential receptor structure is Neu5Ac alpha 3Gal beta 4(Fuc alpha 3)GlcNAc beta 3Gal beta- where Fuc is not absolutely necessary for binding. Our study shows that some human norovirus GII strains have at least two binding specificities: one secretor-gene-dependent related to alpha1,2-fucosylated carbohydrates and another related to alpha2,3-sialylated carbohydrates of the type 2 chain, e.g., sialyl Lewis x.

  3. Cation affinity numbers of Lewis bases.

    PubMed

    Lindner, Christoph; Tandon, Raman; Maryasin, Boris; Larionov, Evgeny; Zipse, Hendrik

    2012-01-01

    Using selected theoretical methods the affinity of a large range of Lewis bases towards model cations has been quantified. The range of model cations includes the methyl cation as the smallest carbon-centered electrophile, the benzhydryl and trityl cations as models for electrophilic substrates encountered in Lewis base-catalyzed synthetic procedures, and the acetyl cation as a substrate model for acyl-transfer reactions. Affinities towards these cationic electrophiles are complemented by data for Lewis-base addition to Michael acceptors as prototypical neutral electrophiles.

  4. Frustrated Lewis pair chemistry: development and perspectives.

    PubMed

    Stephan, Douglas W; Erker, Gerhard

    2015-05-26

    Frustrated Lewis pairs (FLPs) are combinations of Lewis acids and Lewis bases in solution that are deterred from strong adduct formation by steric and/or electronic factors. This opens pathways to novel cooperative reactions with added substrates. Small-molecule binding and activation by FLPs has led to the discovery of a variety of new reactions through unprecedented pathways. Hydrogen activation and subsequent manipulation in metal-free catalytic hydrogenations is a frequently observed feature of many FLPs. The current state of this young but rapidly expanding field is outlined in this Review and the future directions for its broadening sphere of impact are considered.

  5. Development of a Lewis Base Catalyzed Selenocyclization Reaction

    ERIC Educational Resources Information Center

    Collins, William

    2009-01-01

    The concept of Lewis base activation of selenium Lewis acids has been effectively reduced to practice in the Lewis base catalyzed selenofunctionalization of unactivated olefins. In this reaction, the weakly acidic species, "N"-phenylselenyl succinimide, is cooperatively activated by the addition of a "soft" Lewis base donor (phosphine sulfides,…

  6. The Use of C. S. Lewis's "Poems" for Oral Interpretation.

    ERIC Educational Resources Information Center

    Keefe, Carolyn

    Suggestions are offered in this paper for adapting C. S. Lewis's poems for oral interpretation. A discussion of Lewis's lifelong correspondence with his friend Arthur Greeves provides insights into Lewis's perceptions of his own writing. Eighty poems selected from Lewis's "Poems" as appropriate for oral interpretation are classified…

  7. G. N. Lewis and the Chemical Bond.

    ERIC Educational Resources Information Center

    Pauling, Linus

    1984-01-01

    Discusses the contributions of G. N. Lewis to chemistry, focusing on his formulation of the basic principle of the chemical bond--the idea that the chemical bond consists of a pair of electrons held jointly by two atoms. (JN)

  8. Pueblo Pottery: Continuity and Change. Lucy Lewis.

    ERIC Educational Resources Information Center

    Herzog, Melanie

    1991-01-01

    Describes Lucy Lewis' ceramic work which is inspired by the ancient pottery of her Acoma Pueblo artistic heritage. Discusses concepts of tradition, artistic heritage, and change over time. Outlines related ceramic and discussion activities for elementary and secondary students. (KM)

  9. 90 Seconds of Discovery: Frustrated Lewis Pairs

    SciTech Connect

    Kathmann, Shawn; Schenter, Greg; Autrey, Tom

    2014-02-14

    Hydrogen activating catalysts play an important role in producing valuable chemicals, such as biofuels and ammonia. As a part of efforts to develop the next generation of these catalysts, PNNL researchers have found potential in Frustrated Lewis Pairs.

  10. Abegg, Lewis, Langmuir, and the Octet Rule.

    ERIC Educational Resources Information Center

    Jensen, William B.

    1984-01-01

    Discusses major events leading to the development of the octet rule. Three conclusions based on the work of Mendeleev, Abegg, Thompson, Kossel, Lewis, and Langmuir are considered as is the debate over the rule's validity. (JN)

  11. 90 Seconds of Discovery: Frustrated Lewis Pairs

    ScienceCinema

    Kathmann, Shawn; Schenter, Greg; Autrey, Tom

    2016-07-12

    Hydrogen activating catalysts play an important role in producing valuable chemicals, such as biofuels and ammonia. As a part of efforts to develop the next generation of these catalysts, PNNL researchers have found potential in Frustrated Lewis Pairs.

  12. Lewis Research Center: Commercialization Success Stories

    NASA Technical Reports Server (NTRS)

    Heyward, Ann O.

    1996-01-01

    The NASA Lewis Research Center, located in Cleveland, Ohio, has a portfolio of research and technology capabilities and facilities that afford opportunities for productive partnerships with industry in a broad range of industry sectors. In response to the President's agenda in the area of technology for economic growth (Clinton/Gore 1993), the National Performance Review (1993), NASA's Agenda for Change (1994), and the needs of its customers, NASA Lewis Research Center has sought and achieved significant successes in technology transfer and commercialization. This paper discusses a sampling of Lewis Research Center's successes in this area, and lessons learned that Lewis Research Center is applying in pursuit of continuous improvement and excellence in technology transfer and commercialization.

  13. Investigation of Lewis acid versus Lewis base catalysis in asymmetric cyanohydrin synthesis.

    PubMed

    North, Michael; Omedes-Pujol, Marta; Williamson, Courtney

    2010-10-04

    The asymmetric addition of trimethylsilyl cyanide to aldehydes can be catalysed by Lewis acids and/or Lewis bases, which activate the aldehyde and trimethylsilyl cyanide, respectively. It is not always apparent from the structure of the catalyst whether Lewis acid or Lewis base catalysis predominates. To investigate this in the context of using salen complexes of titanium, vanadium and aluminium as catalysts, a Hammett analysis of asymmetric cyanohydrin synthesis was undertaken. When Lewis acid catalysis is dominant, a significantly positive reaction constant is observed, whereas reactions dominated by Lewis base catalysis give much smaller reaction constants. [{Ti(salen)O}(2)] was found to show the highest degree of Lewis acid catalysis, whereas two [VO(salen)X] (X=EtOSO(3) or NCS) complexes both displayed lower degrees of Lewis acid catalysis. In the case of reactions catalysed by [{Al(salen)}(2)O] and triphenylphosphine oxide, a non-linear Hammett plot was observed, which is indicative of a change in mechanism with increasing Lewis base catalysis as the carbonyl compound becomes more electron-deficient. These results suggested that the aluminium complex/triphenylphosphine oxide catalyst system should also catalyse the asymmetric addition of trimethylsilyl cyanide to ketones and this was found to be the case.

  14. The man who loved flies: a biographical profile of Nelson Papavero .

    PubMed

    Klassa, Bruna; Santos, Charles Morphy D

    2014-04-29

    Nelson Papavero is one of the major Brazilian zoologists. His contribution to the field began in the second half of the twentieth century, when he started publishing in the areas of entomology, systematics, biogeography, and history of science, while working at graduate courses and training teachers and students. Papavero was one of the earliest Brazilian advocates of Hennig's phylogenetic systematics. In his entomological work, his first widely recognised works were the Catalogue of South American Diptera and his essays on the history of Neotropical Dipterology. Papavero's greatest contribution however, is in his Special Courses on Zoological Systematics, as well as his numerous administrative positions during his academic career. All these were fundamental to the development of zoology and comparative biology in Brazil and other Latin American countries. Here we present a biography of Nelson Papavero, along with several personal anecdotes, and his role in the development of Brazilian biological systematics over the last 50 years. 

  15. Research and technology, Lewis Research Center

    NASA Technical Reports Server (NTRS)

    1985-01-01

    The NASA Lewis Research Center's research and technology accomplishments for fiscal year 1985 are summarized. The report is organized into five major sections covering aeronautics, aerospace technology, spaceflight systems, space station systems, and computational technology support. This organization of the report roughly parallels the organization of the Center into directorates. Where appropriate, subheadings are used to identify special topics under the major headings. Results of all research and technology work performed during the fiscal year are contained in Lewis-published technical reports and presentations prepared either by Lewis scientists and engineers or by contractor personnel. In addition, significant results are presented by university faculty or graduate students in technical sessions and in journals of the technical societies. For the reader who desires more information about a particular subject, the Lewis contact will provide that information or references. In 1985, five Lewis products were selected by Research and Development Magazine for IR-100 awards. All are described and identified. In addition, the Lewis Distinguished Paper for 1984 to 1985, which was selected by the Chief Scientist and a research advisory board, is included and so identified.

  16. Positron emission tomography-computed tomography coregistration for diagnosis and intraoperative localization in recurrent nelson syndrome.

    PubMed

    Hintz, Eric B; Tomlin, Jeffery M; Chengazi, Vaseem; Vates, G Edward

    2013-06-01

    Recurrent pituitary disease presents unique challenges, including in some cases difficulty localizing a tumor radiographically. Here, we present the case of a patient with recurrent Nelson syndrome whose radiographic work-up was complicated by a significant parasellar metallic artifact. Positron emission tomography ultimately localized the lesion, and coregistration with computed tomography allowed for accurate intraoperative navigation. Additionally, we review a range of imaging techniques available in the evaluation of pituitary disease.

  17. STS-26 MS Nelson during training exercise in JSC Mockup and Integration Lab

    NASA Technical Reports Server (NTRS)

    1988-01-01

    STS-26 Discovery, Orbiter Vehicle (OV) 103, Mission Specialist (MS) George D. Nelson, wearing navy blue launch and entry suit (LES) and launch and entry helmet (LEH), is seated in his launch and entry position on crew compartment trainer (CCT) middeck during a training exercise in JSC Mockup and Integration Laboratory Bldg 9A. Visible in the background are the airlock, stowed treadmill, and sleep restraints. NOTE: Photo was taken by William H. Bowers, crew photo instructor, with wide angle lens.

  18. Preliminary report on the Nelson and Radovan copper prospects, Nizina district, Alaska

    USGS Publications Warehouse

    Sainsbury, C.J.

    1952-01-01

    Renewed copper exploration by Alaska Copper Mines, Incorporated, at the Nelson and Radovan prospects, Nizina district, Alaska, led the Geological Survey in 1951 to map in detail the Nelson fault block, and to re-examine the old workings. In addition, two new prospects were studied. The Nelson fault block is cut by many dominantly strike-slip faults of small displacement, and by bedding faults. Slickensided chalcocite shows post-mineral movement, and chalcocite veinlet in a filled solution cavity indicates that some of the chalcocite is secondary, perhaps very recent. Structural relations indicate two overthrust faults cut the block. The Radovan Greenstone prospect shows massive chalcocite, up to 3 feet wide, in a silicified, epidotized fault zone in the Nikolai greenstone. Ore indicated by surface exposures may amount to 450 tons of chalcocite. The Radovan Low-Contact prospect is on a continuation of the same fault approximately 3 miles southwest of the Greenstone prospect, and 150 feet above the contact of the Nikolai greenstone and the overlying Chitistone limestone. Limonite staining is widespread in bedding planes and small faults near the fault zone; mineralization in the fault zone consists of pyrite, chalcocite, bornite, malachite, realgar, orpiment and stibnite. The sulphides in the fault zone, plus the widespread silicification and epidotization indicate a strong zone of hydrothermal activity which merits extensive prospecting.

  19. Multichannel alternate electrostimulation using the new Bulgarian Vita 2007 equipment in post-stroke rehabilitation.

    PubMed

    Ilieva, E; Marinkev, M

    1999-01-01

    In this study the authors evaluated the effect of a new method--multichannel alternate electrostimulation using the new Bulgarian equipment Vita 2007 for regulating muscular imbalance, breaking the pathological synergic patterns and overcoming motor impairment after stroke. The subjects of the study were 15 patients with hemiparesis secondary to stroke. The beneficial results in accelerating motor recovery and assisting the physical exercise programme for recreating proper patterns of walking and manipulative activity were assigned to the change in the level of spasticity and to the new method of consecutive alternate stimulation of the muscles that take part in the normal movement.

  20. Scales of Lewis basicities toward C-centered Lewis acids (carbocations).

    PubMed

    Mayr, Herbert; Ammer, Johannes; Baidya, Mahiuddin; Maji, Biplab; Nigst, Tobias A; Ofial, Armin R; Singer, Thomas

    2015-02-25

    Equilibria for the reactions of benzhydryl cations (Ar2CH(+)) with phosphines, tert-amines, pyridines, and related Lewis bases were determined photometrically in CH2Cl2 and CH3CN solution at 20 °C. The measured equilibrium constants can be expressed by the sum of two parameters, defined as the Lewis Acidity (LA) of the benzhydrylium ions and the Lewis basicity (LB) of the phosphines, pyridines, etc. Least-squares minimization of log K = LA + LB with the definition LA = 0 for (4-MeOC6H4)2CH(+) gave a Lewis acidity scale for 18 benzhydrylium ions covering 18 orders of magnitude in CH2Cl2 as well as Lewis basicities (with respect to C-centered Lewis acids) for 56 bases. The Lewis acidities correlated linearly with the quantum chemically calculated (B3LYP/6-311++G(3df,2pd)//B3LYP/6-31G(d,p) level) methyl anion affinities of the corresponding benzhydrylium ions, which can be used as reference compounds for characterizing a wide variety of Lewis bases. The equilibrium measurements were complemented by isothermal titration calorimetry studies. Rates of SN1 solvolyses of benzhydryl chlorides, bromides, and tosylates derived from E(13-33)(+), i.e., from highly reactive carbocations, correlate excellently with the corresponding Lewis acidities and the quantum chemically calculated methyl anion affinities. This correlation does not hold for solvolyses of derivatives of the better stabilized amino-substituted benzhydrylium ions E(1-12)(+). In contrast, the correlation between electrophilic reactivities and Lewis acidities (or methyl anion affinities) is linear for all donor-substituted benzhydrylium ions E(1-21)(+), while the acceptor-substituted benzhydrylium ions E(26-33)(+) react more slowly than expected from their thermodynamic stabilities. The boundaries of linear rate-equilibrium relationships were thus defined.

  1. Rocket Propulsion Research at Lewis Research Center

    NASA Technical Reports Server (NTRS)

    Dawson, Virginia P.

    1992-01-01

    A small contingent of engineers at NASA Lewis Research Center pioneered in basic research on liquid propellants for rockets shortly after World War II. Carried on through the 1950s, this work influenced the important early decisions made by Abe Silverstein when he took charge of the Office of Space Flight Programs for NASA. He strongly supported the development of liquid hydrogen as a propulsion fuel in the face of resistance from Wernher von Braun. Members of the Lewis staff played an important role in bringing liquid hydrogen technology to the point of reliability through their management of the Centaur Program. This paper demonstrates how the personality and engineering intuition of Abe Silverstein shaped the Centaur program and left a lasting imprint on the laboratory research tradition. Many of the current leaders of Lewis Research Center received their first hands-on engineering experience when they worked on the Centaur program in the 1960s.

  2. NASA Lewis Wind Tunnel Model Systems Criteria

    NASA Technical Reports Server (NTRS)

    Soeder, Ronald H.; Haller, Henry C.

    1994-01-01

    This report describes criteria for the design, analysis, quality assurance, and documentation of models or test articles that are to be tested in the aeropropulsion facilities at the NASA Lewis Research Center. The report presents three methods for computing model allowable stresses on the basis of the yield stress or ultimate stress, and it gives quality assurance criteria for models tested in Lewis' aeropropulsion facilities. Both customer-furnished model systems and in-house model systems are discussed. The functions of the facility manager, project engineer, operations engineer, research engineer, and facility electrical engineer are defined. The format for pretest meetings, prerun safety meetings, and the model criteria review are outlined Then, the format for the model systems report (a requirement for each model that is to be tested at NASA Lewis) is described, the engineers that are responsible for developing the model systems report are listed, and the time table for its delivery to the facility manager is given.

  3. Lewis hybrid computing system, users manual

    NASA Technical Reports Server (NTRS)

    Bruton, W. M.; Cwynar, D. S.

    1979-01-01

    The Lewis Research Center's Hybrid Simulation Lab contains a collection of analog, digital, and hybrid (combined analog and digital) computing equipment suitable for the dynamic simulation and analysis of complex systems. This report is intended as a guide to users of these computing systems. The report describes the available equipment' and outlines procedures for its use. Particular is given to the operation of the PACER 100 digital processor. System software to accomplish the usual digital tasks such as compiling, editing, etc. and Lewis-developed special purpose software are described.

  4. The divine clockwork: Bohr's correspondence principle and Nelson's stochastic mechanics for the atomic elliptic state

    SciTech Connect

    Durran, Richard; Neate, Andrew; Truman, Aubrey

    2008-03-15

    We consider the Bohr correspondence limit of the Schroedinger wave function for an atomic elliptic state. We analyze this limit in the context of Nelson's stochastic mechanics, exposing an underlying deterministic dynamical system in which trajectories converge to Keplerian motion on an ellipse. This solves the long standing problem of obtaining Kepler's laws of planetary motion in a quantum mechanical setting. In this quantum mechanical setting, local mild instabilities occur in the Keplerian orbit for eccentricities greater than (1/{radical}(2)) which do not occur classically.

  5. The Translation Invariant Massive Nelson Model: III. Asymptotic Completeness Below the Two-Boson Threshold

    NASA Astrophysics Data System (ADS)

    Dybalski, Wojciech; Møller, Jacob Schach

    2015-11-01

    We show asymptotic completeness of two-body scattering for a class of translation invariant models describing a single quantum particle (the electron) linearly coupled to a massive scalar field (bosons). Our proof is based on a recently established Mourre estimate for these models. In contrast to previous approaches, it requires no number cutoff, no restriction on the particle-field coupling strength, and no restriction on the magnitude of total momentum. Energy, however, is restricted by the two-boson threshold, admitting only scattering of a dressed electron and a single asymptotic boson. The class of models we consider include the UV-cutoff Nelson and polaron models.

  6. Passageless comprehension on the Nelson-Denny reading test: well above chance for university students.

    PubMed

    Coleman, Chris; Lindstrom, Jennifer; Nelson, Jason; Lindstrom, William; Gregg, K Noël

    2010-01-01

    The comprehension section of the Nelson-Denny Reading Test (NDRT) is widely used to assess the reading comprehension skills of adolescents and adults in the United States. In this study, the authors explored the content validity of the NDRT Comprehension Test (Forms G and H) by asking university students (with and without at-risk status for learning disorders) to answer the multiple-choice comprehension questions without reading the passages. Overall accuracy rates were well above chance for both NDRT forms and both groups of students. These results raise serious questions about the validity of the NDRT and its use in the identification of reading disabilities.

  7. STS-26 MS Nelson operates controls for PVTOS-2 experiment on aft middeck

    NASA Technical Reports Server (NTRS)

    1988-01-01

    STS-26 Mission Specialist (MS) George D. Nelson operates generic electronics module for the Physical Vapor Transport of Organic Solids 2 (PVTOS-2) experiment on Discovery's, Orbiter Vehicle (OV) 103's, aft middeck. PVTOS-2 consists of nine independent experimental cells about 12 inches long and 3 inches in diameter. They are mounted in a circular base plate inside the drum-like experimental apparatus container (EAC). PVTOS-2 is sponsored by NASA's Office of Commercial Programs and is being conducted by 3M's Space Research and Applications Laboratory.

  8. The Professoriate in the Field of Educational Administration: Insights from an Analysis of Journal Authors' Curricula Vitae

    ERIC Educational Resources Information Center

    Oplatka, Izhar

    2010-01-01

    Purpose: Based on a qualitative content analysis of 57 curricula vitae of authors who published their work in the major journals of the educational administration (EA) field, this paper seeks to display the career of EA authors and to suggest some epistemological implications for the field. Design/methodology/approach: The analysis is based on…

  9. Visual Interpretation with Three-Dimensional Annotations (VITA): three-dimensional image interpretation tool for radiological reporting.

    PubMed

    Roy, Sharmili; Brown, Michael S; Shih, George L

    2014-02-01

    This paper introduces a software framework called Visual Interpretation with Three-Dimensional Annotations (VITA) that is able to automatically generate three-dimensional (3D) visual summaries based on radiological annotations made during routine exam reporting. VITA summaries are in the form of rotating 3D volumes where radiological annotations are highlighted to place important clinical observations into a 3D context. The rendered volume is produced as a Digital Imaging and Communications in Medicine (DICOM) object and is automatically added to the study for archival in Picture Archiving and Communication System (PACS). In addition, a video summary (e.g., MPEG4) can be generated for sharing with patients and for situations where DICOM viewers are not readily available to referring physicians. The current version of VITA is compatible with ClearCanvas; however, VITA can work with any PACS workstation that has a structured annotation implementation (e.g., Extendible Markup Language, Health Level 7, Annotation and Image Markup) and is able to seamlessly integrate into the existing reporting workflow. In a survey with referring physicians, the vast majority strongly agreed that 3D visual summaries improve the communication of the radiologists' reports and aid communication with patients.

  10. Celebrating the Bicentennial of Lewis and Clark

    ERIC Educational Resources Information Center

    Morris, Ronald V.; McNeely, Jean

    2005-01-01

    Lewis, Clark, and the Corps of Discovery traveled westward from 1803 to 1806; therefore, the bicentennial of the expedition is being celebrated from 2003 until 2006. Students and teachers celebrating the bicentennial and Jefferson's Louisiana Purchase in 1803 can use social studies classes to help them connect with their community and to reach a…

  11. Lewis and Clark--Indiana Connections.

    ERIC Educational Resources Information Center

    Bennett, Pamela J., Ed.

    2003-01-01

    The state of Indiana has an important, recognized connection to the Lewis and Clark Expedition. That connection is reinforced with a National Signature Event in Clarksville (Indiana) during October 2003. Until the expedition party left its winter camp in May 1804, it remained in Indiana Territory, governed from Vincennes (Indiana) by William Henry…

  12. Lewis Mumford and the Ecology of Technics.

    ERIC Educational Resources Information Center

    Strate, Lance; Lum, Casey Man Kong

    2000-01-01

    Examines Lewis Mumford's scholarship and his contribution to the emergence of media ecology as both an intellectual tradition and a theoretical perspective on the study of technology, media, and culture. Focuses on Mumford's epochal historiography of technology, the techno-organicism in his thinking about technology and human development, and his…

  13. Playing around in Lewis Carroll's "Alice" Books

    ERIC Educational Resources Information Center

    Susina, Jan

    2010-01-01

    Mathematician Charles Dodgson's love of play and his need for rules came together in his use of popular games as part of the structure of the two famous children's books, "Alice in Wonderland" and "Through the Looking-Glass," he wrote under the pseudonym Lewis Carroll. The author of this article looks at the interplay between…

  14. Reply to Tone Kvernbekk and Ann Lewis

    ERIC Educational Resources Information Center

    Tangen, Reidun

    2008-01-01

    The purpose of this reply to Kvernbekk and Lewis's comments regarding the discussion on epistemological and ethical problems of listening to children's voices, is not to propose a coherent foundation free from any epistemological tensions. Rather, Tangen's intent is primarily to explore different perspectives in order to disclose some of their…

  15. Composites research at NASA Lewis Research Center

    NASA Technical Reports Server (NTRS)

    Levine, Stanley R.; Duffy, Stephen; Vary, Alex; Nathal, Michael V.; Miner, Robert V.; Arnold, Steven M.; Castelli, Michael G.; Hopkins, Dale A.; Meador, Michael A.

    1994-01-01

    Composites research at NASA Lewis is focused on their applications in aircraft propulsion, space propulsion, and space power, with the first being predominant. Research on polymer-, metal-, and ceramic-matrix composites is being carried out from an integrated materials and structures viewpoint. This paper outlines some of the topics being pursued from the standpoint of key technical issues, current status, and future directions.

  16. Teaching a Model for Writing Lewis Structures.

    ERIC Educational Resources Information Center

    Pardo, Juan Quilez

    1989-01-01

    Presents a didactic model to improve the teaching/learning process in the representation of Lewis structures. Places special emphasis on the calculation and reduction of formal charges, and in the representation of molecules in which the central atom has expanded its valence shell. (MVL)

  17. Teaching Beginning Chemistry Students Simple Lewis Dot Structures

    ERIC Educational Resources Information Center

    Nassiff, Peter; Czerwinski, Wendy A.

    2015-01-01

    Students beginning their initial study of chemistry often have a difficult time mastering simple Lewis dot structures. Textbooks show students how to manipulate Lewis structures by moving valence electron dots around the chemical structure so each atom has an octet or duet. However, an easier method of teaching Lewis structures for simple…

  18. An Overview of Lewis Basicity and Affinity Scales

    ERIC Educational Resources Information Center

    Laurence, Christian; Graton, Jerome; Gal, Jean-Francois

    2011-01-01

    The impossibility of establishing a universal scale of Lewis basicity does not prevent the determination of the quantitative behavior of Lewis bases, thanks to scales constructed against particular Lewis acids: BF[subscript 3], 4-FC[subscript 6]H[subscript 4]OH, I[subscript 2], Li[superscript +], Na[superscript +], K[superscript +], Al[superscript…

  19. Prospective Assessment of an innovative test for prostate cancer screening using the VITA process model framework.

    PubMed

    Gantner-Bär, Marion; Meier, Florian; Kolominsky-Rabas, Peter; Djanatliev, Anatoli; Metzger, Armin; Voigt, Wieland; Prokosch, Hans-Ulrich; Sedlmayr, Martin

    2014-01-01

    Healthcare innovations are crucial for enhancing patient treatment and a high-quality healthcare system. However, bringing new technologies, methods and procedures into the healthcare market is challenging. Enormous amounts of financial, personnel and organizational resources are required with no upfront certainty for the medical and economic benefit. A new and innovative approach uses interdisciplinary medical, technical and economic expertise to forecast effects of healthcare innovations already at the early research and concept phase of an idea and before major investments are made. A process model framework was developed to operationalize this structured assessment of healthcare innovations. The Visionary Iterative Tailored Approach (VITA) is based on conceptual modeling, simulation and health economics evaluation. Its application for the prospective assessment of an innovative prostate cancer screening is presented.

  20. Up-date on the NeoVitaA Trial: Obstacles, challenges, perspectives, and local experiences.

    PubMed

    Meyer, Sascha; Gortner, Ludwig

    2016-09-26

    The aim of the NeoVitaA Trial is to assess the role of postnatal additional high-dose oral vitamin A supplementation for 28 days in reducing Bronchopulmonary dysplasia (BPD) or death in extremely low birth weight (ELBW) infants at 36 weeks postmenstrual age (PMA). All infants (both intervention and control group) will be provided with basic vitamin A (1000 IU/kg/day) in addition to trial intervention.In this short communication, we will give an up-date on obstacles, challenges as well as perspectives and potential solutions when putting into place a multicenter, double-blind, randomized trial in this cohort of extremely susceptible infants.

  1. Development and validation of detailed controls models of the Nelson River Bipole 1 HVDC system

    SciTech Connect

    Kuffel, P.; Kent, K.L.; Mazur, G.B.; Weekes, M.A. )

    1993-01-01

    With the Nelson River Bipole 1 mercury arc valve group replacement project and planning for the expansion of the Nelson River HVDC system with a third bipole underway, it was decided to pursue a program to develop and validate detailed models of the existing HVDC transmission facilities and their associated ac systems for use in system studies. The first phase of the program concentrated on the development of detailed controls models associated with the Bipole 1 transmission facility. Based on previous experience at Manitoba Hydro with the Electromagnetic Transient DC simulation program (EMTDC), it was decided that model development and validation would use this program. This paper presents the reasons behind the development of detailed models, the methods used in developing models related to Bipole 1, results of validation tests, difficulties encountered during the process, and the overall benefits resulting from the project. An example of applying the models to investigate a low frequency oscillation which has occurred on the dc system in the past is also presented.

  2. Identifying Hydrological Controls in the Lower Nelson River Basin utilizing Stable Water Isotopes

    NASA Astrophysics Data System (ADS)

    Delavau, C. J.; Smith, A. A.; Stadnyk, T.; Koenig, K.

    2012-12-01

    In 2010 a Stable Water Isotope (SWI) Monitoring Network was established within the lower Nelson River Basin (LNRB) (approximately 90,000 km2) in northern Manitoba, Canada, through a joint collaboration between the University of Manitoba and Manitoba Hydro (MH). The monitoring network encompasses over 60 sites where surface waters are regularly sampled, four sites sampling isotopes in precipitation, two sites utilizing drive point piezometers for the isotopic sampling of baseflow waters, and one site collecting evaporatively enriched water samples from an evaporation pan. In addition, two synoptic surveys have been completed in June 2011 and July 2012 to obtain annual snapshots of the monitoring network at a point in time. Currently, over 700 samples have been collected and analyzed. The LNRB contains approximately 9% of the total Nelson River Basin (NRB) drainage area, which encompasses an area of over 1 million km2. A diversion from the Churchill River through the Rat/Burntwood system routes an additional portion of flow into the northwest portion of the LNRB. The LNRB is significant to MH's network as it represents 75% of their power generation potential through six generating stations, thus resulting in a large portion of the basin being regulated. The watershed is topographically flat, therefore the movement and runoff of water, as well as isotopic composition of streamflow, is suspected to be highly impacted by changes in landscape and hydrography. The LNRB is a coniferous and wetland dominated basin, with almost 35% of the land cover composed of coniferous forest and 40% comprised of wetlands and lakes. Interpretation of the LNRB isotope framework shows that the major water sources (rainfall, snowfall, groundwater and surface waters) and rivers are isotopically distinct from one another. The main stem of the Nelson River shows little spatial or temporal variability, with an average δ18O of -10.6‰ and a standard deviation of 0.5‰ throughout the sampling

  3. Investigating the Lewis acidity of aluminium fluoride surfaces

    NASA Astrophysics Data System (ADS)

    Bailey, C. L.; Mukhopadhyay, S.; Wander, A.; Harrison, N. M.

    2008-03-01

    The current study employs state of the art hybrid-exchange density functional theory (DFT) to investigate the Lewis acidic sites on the β-AlF3 (100) surface. It is shown that the strong Lewis base, NH3, binds to the surface with a binding energy of up to 1.9 eV. This demonstrates that the material is strongly Lewis acidic. We also consider the binding of the weak Lewis base CO to the surface. We calculate the shift in its stretch frequency compared to the gas phase molecule. Shifts are compared to experimental data and are shown to be typical of strong Lewis acidity.

  4. Modern Exploration of the Lewis and Clark Expedition

    NASA Technical Reports Server (NTRS)

    2006-01-01

    The Lewis and Clark Geosystem is an online collection of private, state, local, and Federal data resources associated with the geography of the Lewis and Clark Expedition. Data were compiled from key partners including NASA s Stennis Space Center, the U.S. Army Corps of Engineers, the U.S. Fish and Wildlife Service, the U.S. Geological Survey (USGS), the University of Montana, the U.S. Department of Agriculture Forest Service, and from a collection of Lewis and Clark scholars. It combines modern views of the landscape with historical aerial photography, cartography, and other geographical data resources and historical sources, including: The Journals of the Lewis and Clark Expedition, the Academy of Natural Science's Lewis and Clark Herbarium, high-resolution copies of the American Philosophical Society s primary-source Lewis and Clark Journals, The Library of Congress Lewis and Clark cartography collection, as well as artifacts from the Smithsonian Institution and other sources.

  5. A Biography of Distinguished Scientist Gilbert Newton Lewis (by Edward S. Lewis)

    NASA Astrophysics Data System (ADS)

    Harris, Reviewed By Harold H.

    1999-11-01

    The Edward Mellen Press: Lewiston, NY, 1998. 114 pp + index. ISBN 0-7734-8284-9. $69.95. There may not be a surname better known to students of chemistry than Lewis, from the Lewis electron-dot diagrams and the Lewis theory of acids and bases. More advanced students may know of the groundbreaking textbook Thermodynamics, by Lewis and Randall. Yet few Americans know much about this remarkable U.S.-born scholar, whose contributions equal those of the greatest scientists. He is a chemist-educator of whom we should be as proud and as well informed as we are of Linus Pauling, who was part of the westward movement of science in this country that G. N. Lewis began, or of the recently deceased Glenn Seaborg, who was one of the many students of Lewis who achieved renown. Gilbert N. Lewis was born in Weymouth, Massachusetts, in 1875, but his family moved to near Lincoln, Nebraska, in 1884. He spent two years at the University of Nebraska, but then moved to Harvard when his father became an executive at Merchants Trust Company in Boston. Young Lewis (then only 17) was also said to have been disappointed with the quality of education in Nebraska, and this may have been part of the impetus for the family's move east. After earning his baccalaureate at Harvard, he taught for a year at Phillips Andover Academy before returning to Harvard to study for his doctorate, which he completed 100 years ago, in 1899, under T. W. Richards. Lewis's doctoral work was on the thermodynamics of zinc and cadmium amalgams. At that time, physical chemistry was only beginning to achieve recognition as a branch of science, and its boundaries were ill defined. Edward Lewis quotes his father as often saying, "Physical chemistry is anything interesting." Like many chemists of his time, Lewis went to Europe to complete his preparation for a career; he was in the laboratories of Ostwald in Leipzig and Nernst in Göttingen in 1900-1901. On his return to the United States, he was an instructor at Harvard

  6. Determination of critical habitat for the endangered Nelson's bighorn sheep in southern California

    USGS Publications Warehouse

    Turner, J.C.; Douglas, C.L.; Hallum, C.R.; Krausman, P.R.; Ramey, R.R.

    2004-01-01

    The United States Fish and Wildlife Service's (USFWS) designation of critical habitat for the endangered Nelson's bighorn sheep (Ovis canadensis nelsoni) in the Peninsular Ranges of southern California has been controversial because of an absence of a quantitative, repeatable scientific approach to the designation of critical habitat. We used 12,411 locations of Nelson's bighorn sheep collected from 1984-1998 to evaluate habitat use within 398 km2 of the USFWS-designated critical habitat in the northern Santa Rosa Mountains, Riverside County, California. We developed a multiple logistic regression model to evaluate and predict the probability of bighorn use versus non-use of native landscapes. Habitat predictor variables included elevation, slope, ruggedness, slope aspect, proximity to water, and distance from minimum expanses of escape habitat. We used Earth Resources Data Analysis System Geographic Information System (ERDAS-GIS) software to view, retrieve, and format predictor values for input to the Statistical Analysis Systems (SAS) software. To adequately account for habitat landscape diversity, we carried out an unsupervised classification at the outset of data inquiry using a maximum-likelihood clustering scheme implemented in ERDAS. We used the strata resulting from the unsupervised classification in a stratified random sampling scheme to minimize data loads required for model development. Based on 5 predictor variables, the habitat model correctly classified >96% of observed bighorn sheep locations. Proximity to perennial water was the best predictor variable. Ninety-seven percent of the observations were within 3 km of perennial water. Exercising the model over the northern Santa Rosa Mountain study area provided probabilities of bighorn use at a 30 x 30-m2 pixel level. Within the 398 km 2 of USFWS-designated critical habitat, only 34% had a graded probability of bighorn use to non-use ranging from ???1:1 to 6,044:1. The remaining 66% of the study area

  7. Anionic Lewis Acids. A Chemical Oxymoron.

    DTIC Science & Technology

    1995-10-17

    NUMBER OF PAGES12 anionic lewis acid ab initio synthesis 1 2 methide FT NMR 16. PRICE CODE imide multi-nule r 17. SECURITY CLASSIFICATION 18...chemically robust, thermally stable, non-toxic, environmentally safe, and cost-effective. One of our current areas of interest involves the synthesis and...developing a predictive knowledge base that can be used to guide the synthesis of new locally electron-deficient anions. Additionally, we proposed to

  8. Calcium-based Lewis acid catalysts.

    PubMed

    Begouin, Jeanne-Marie; Niggemann, Meike

    2013-06-17

    Recently, Lewis acidic calcium salts bearing weakly coordinating anions such as Ca(NTf₂)₂, Ca(OTf)₂, CaF₂ and Ca[OCH(CF₃)₂]₂ have been discovered as catalysts for the transformation of alcohols, olefins and carbonyl compounds. High stability towards air and moisture, selectivity and high reactivity under mild reaction conditions render these catalysts a sustainable and mild alternative to transition metals, rare-earth metals or strong Brønsted acids.

  9. Polymerization by classical and frustrated Lewis pairs.

    PubMed

    Chen, Eugene Y-X

    2013-01-01

    Main-group classical and frustrated Lewis pairs (CLPs and FLPs) comprising strong Lewis acids (LAs) and strong Lewis bases (LBs) are highly active for polymerization of conjugated polar alkenes, affording typically high molecular weight polymers with relatively narrow molecular weight distributions. Especially effective systems are the Lewis pairs (LPs) consisting of the strong LA Al(C6F5)3 and strong LBs, such as achiral phosphines and chiral chelating diphosphines, N-heterocyclic carbenes, and phosphazene superbases, for polymerization of methacrylates and acrylamides as well as renewable α-methylene-γ-butyrolactones. Chain initiation involves cooperative addition of LPs to the monomer to generate zwitterionic active species, and chain propagation proceeds via a bimetallic, activated-monomer addition mechanism. Transition metal nucleophile/electrophile pairs comprising neutral metallocene bis(ester enolate)s and strong LAs E(C6F5)3 (E = Al, B) generate two drastically different polymerization systems, depending on the LA. With E = Al, catalyst activation and chain initiating events lead to dually active ion-pairs, thereby effecting ion-pairing polymerization that affords polymers with unique stereo-multiblock microstructures. With E = B, on the other hand, the FLP-induced catalyst activation generates metallacyclic cations paired with the hydridoborate anion [HB(C6F5)3](-); uniquely, such ion-pairs effect catalytic polymerization of conjugated polar alkenes by an H-shuttling mechanism, with the cation catalyzing chain growth and the anion promoting chain transfer by shuttling the hydride between the cation and anion centers through the neutral borane.

  10. NASA Lewis' IITA K-12 Program

    NASA Technical Reports Server (NTRS)

    1996-01-01

    The NASA Lewis Research Center's Information Infrastructure Technology and Applications for Kindergarten to 12th Grade (IITA K-12) Program is designed to introduce into school systems computing and communications technology that benefits math and science studies. By incorporating this technology into K-12 curriculums, we hope to increase the proficiency and interest in math and science subjects by K-12 students so that they continue to study technical subjects after their high school careers are over.

  11. A Lewis acid-mediated conformational switch.

    PubMed

    Knipe, Peter C; Lingard, Hannah; Jones, Ian M; Thompson, Sam; Hamilton, Andrew D

    2014-10-28

    Molecules that change conformation in response to a stimulus have numerous uses, such as artificial chemoreceptors, novel drug delivery strategies and liquid crystal technology. Here we describe the design, synthesis and conformational behaviour of an isonicotinamide-substituted diphenylacetylene upon recognition of Lewis acids, including metalloporphyrins. Binding of these at a remote site - the pyridyl nitrogen - increases hydrogen-bond donor ability of the proximal amide NH, causing an increased preference for the alkyne rotamer in which this hydrogen bond is maintained.

  12. Maudlin's challenge refuted: A reply to Lewis

    NASA Astrophysics Data System (ADS)

    Kastner, Ruth E.

    2014-08-01

    Lewis has recently argued that Maudlin's contingent absorber experiment remains a significant problem for the Transactional Interpretation (TI). He argues that the only straightforward way to resolve the challenge is by describing the absorbers as offer waves, and asserts that this is a previously unnoticed aspect of the challenge for TI. This argument is refuted in two basic ways: (i) it is noted that the Maudlin experiment cannot be meaningfully recast with absorbers described by quantum states; instead the author replaces it with an ordinary which-way experiment; and (ii) the extant rebuttals to the Maudlin challenge in its original form are not in fact subject to the alleged flaws that Lewis ascribes to them. This paper further seeks to clarify the issues raised in Lewis' presentation concerning the distinction between quantum systems and macroscopic objects in TI. It is noted that the latest, possibilist version of TI (PTI) has no ambiguity concerning macroscopic absorbers. In particular, macroscopic objects are not subject to indeterminate trajectories, since they are continually undergoing collapse. It is concluded that the Maudlin challenge poses no significant problem for the transactional interpretation.

  13. Lewis' Educational and Research Collaborative Internship Program

    NASA Technical Reports Server (NTRS)

    Heyward, Ann; Gott, Susan (Technical Monitor)

    2004-01-01

    The Lewis Educational and Research Collaborative Internship Program (LERCIP) is a collaborative undertaking by the Office of Educational Programs at NASA Glenn Research Center at Lewis Field (formerly NASA Lewis Research Center) and the Ohio Aerospace Institute. This program provides 10-week internships in addition to summer and winter extensions if funding is available and/or is requested by mentor (no less than 1 week no more than 4 weeks) for undergraduate/graduate students and secondary school teachers. Students who meet the travel reimbursement criteria receive up to $500 for travel expenses. Approximately 178 interns are selected to participate in this program each year and begin arriving the fourth week in May. The internships provide students with introductory professional experiences to complement their academic programs. The interns are given assignments on research and development projects under the personal guidance of NASA professional staff members. Each intern is assigned a NASA mentor who facilitates a research assignment. In addition to the research assignment, the summer program includes a strong educational component that enhances the professional stature of the participants. The educational activities include a research symposium and a variety of workshops, and lectures. An important aspect of the program is that it includes students with diverse social, cultural and economic backgrounds. The purpose of this report is to document the program accomplishments for 2004.

  14. Lewis Information Network (LINK): Background and overview

    NASA Technical Reports Server (NTRS)

    Schulte, Roger R.

    1987-01-01

    The NASA Lewis Research Center supports many research facilities with many isolated buildings, including wind tunnels, test cells, and research laboratories. These facilities are all located on a 350 acre campus adjacent to the Cleveland Hopkins Airport. The function of NASA-Lewis is to do basic and applied research in all areas of aeronautics, fluid mechanics, materials and structures, space propulsion, and energy systems. These functions require a great variety of remote high speed, high volume data communications for computing and interactive graphic capabilities. In addition, new requirements for local distribution of intercenter video teleconferencing and data communications via satellite have developed. To address these and future communications requirements for the next 15 yrs, a project team was organized to design and implement a new high speed communication system that would handle both data and video information in a common lab-wide Local Area Network. The project team selected cable television broadband coaxial cable technology as the communications medium and first installation of in-ground cable began in the summer of 1980. The Lewis Information Network (LINK) became operational in August 1982 and has become the backbone of all data communications and video.

  15. Structure of an anti-Lewis X Fab fragment in complex with its Lewis X antigen.

    PubMed

    van Roon, Anne-Marie M; Pannu, Navraj S; de Vrind, Johannes P M; van der Marel, Gijs A; van Boom, Jacques H; Hokke, Cornelis H; Deelder, André M; Abrahams, Jan Pieter

    2004-07-01

    The Lewis X trisaccharide is pivotal in mediating specific cell-cell interactions. Monoclonal antibody 291-2G3-A, which was generated from mice infected with schistosomes, has been shown to recognize the Lewis X trisaccharide. Here we describe the structure of the Fab fragment of 291-2G3-A, with Lewis X, to 1.8 A resolution. The crystallographic analysis revealed that the antigen binding site is a rather shallow binding pocket, and residues from all six complementary determining regions of the antibody contact all sugar residues. The high specificity of the binding pocket does not result in high affinity; the K(D) determined by isothermal calorimetry is 11 microM. However, this affinity is in the same range as for other sugar-antibody complexes. The detailed understanding of the antibody-Lewis X interaction revealed by the crystal structure may be helpful in the design of better diagnostic tools for schistosomiasis and for studying Lewis X-mediated cell-cell interactions by antibody interference.

  16. Dual Lewis Acid/Lewis Base Catalyzed Acylcyanation of Aldehydes: A Mechanistic Study.

    PubMed

    Laurell Nash, Anna; Hertzberg, Robin; Wen, Ye-Qian; Dahlgren, Björn; Brinck, Tore; Moberg, Christina

    2016-03-07

    A mechanistic investigation, which included a Hammett correlation analysis, evaluation of the effect of variation of catalyst composition, and low-temperature NMR spectroscopy studies, of the Lewis acid-Lewis base catalyzed addition of acetyl cyanide to prochiral aldehydes provides support for a reaction route that involves Lewis base activation of the acyl cyanide with formation of a potent acylating agent and cyanide ion. The cyanide ion adds to the carbonyl group of the Lewis acid activated aldehyde. O-Acylation by the acylated Lewis base to form the final cyanohydrin ester occurs prior to decomplexation from titanium. For less reactive aldehydes, the addition of cyanide is the rate-determining step, whereas, for more reactive, electron-deficient aldehydes, cyanide addition is rapid and reversible and is followed by rate-limiting acylation. The resting state of the catalyst lies outside the catalytic cycle and is believed to be a monomeric titanium complex with two alcoholate ligands, which only slowly converts into the product.

  17. The Relationship Between Nelson-Denny Test Scores and Academic Performance of Educational Opportunity Program Students. EAC Reports.

    ERIC Educational Resources Information Center

    Yamagishi, Midori; Gillmore, Gerald M.

    The relationship of Nelson-Denny Reading Test scores and an English course placement recommendation to academic success of Educational Opportunity Program students at the University of Washington was studied. The placement recommendation was based on a writing sample and test scores. The 207 freshmen students who entered in either 1976 or 1978…

  18. Commentary: The Development of Hippocampal-Dependent Memory Functions: Theoretical Comments on Jabès and Nelson Review (2015)

    ERIC Educational Resources Information Center

    Bachevalier, Jocelyne

    2015-01-01

    Studies investigating the development of memory processes and their neural substrates have flourished over the past two decades. The review by Jabès and Nelson (2015) adds an important piece to our understanding of the maturation of different elements and circuits within the hippocampal system and their association with the progressive development…

  19. The "Naked Truth" Isn't Very Revealing: A Response to Wade Nelson on School Reform in Minnesota.

    ERIC Educational Resources Information Center

    Pitton, Debra Eckerman

    1999-01-01

    A participant in Minnesota's standards-based reform initiative claims Wade Nelson, in his May 1998 "Kappan" article, is misinformed about teachers' exclusion from this movement. The standards constitute a minimal competence level in reading, math, and writing, were developed cooperatively, and have raised teacher expectations of…

  20. Mixing and photoreactivity of dissolved organic matter in the Nelson/Hayes estuarine system (Hudson Bay, Canada)

    NASA Astrophysics Data System (ADS)

    Guéguen, C.; Mokhtar, M.; Perroud, A.; McCullough, G.; Papakyriakou, T.

    2016-09-01

    This work presents the results of a 4-year study (2009-2012) investigating the mixing and photoreactivity of dissolved organic matter (DOM) in the Nelson/Hayes estuary (Hudson Bay). Dissolved organic carbon (DOC), colored DOM, and humic-like DOM decreased with increasing salinity (r2 = 0.70-0.84). Removal of DOM was noticeable at low to mid salinity range, likely due to degradation and/or adsorption to particles. DOM photobleaching rates (i.e., decrease in DOM signal resulting from exposure to solar radiation) ranged from 0.005 to 0.030 h- 1, corresponding to half-lives of 4.9-9.9 days. Dissolved organic matter from the Nelson and Hayes Rivers was more photoreactive than from the estuary where the photodegradation of terrestrial DOM decreased with increasing salinity. Coincident with the loss of CDOM absorption was an increase in spectral slope S, suggesting a decrease in DOM molecular weight. Marked differences in photoreactivity of protein- and humic-like DOM were observed with highly humidified material being the most photosensitive. Information generated by our study will provide a valuable data set for better understanding the impacts of future hydroelectric development and climate change on DOM biogeochemical dynamics in the Nelson/Hayes estuary and coastal domain. This study will constitute a reference on terrestrial DOM fate prior to building additional generating capacity on the Nelson River.

  1. Comments on Mika's Critique of Hartnett, Nelson, and Rinn's Article, "Gifted or ADHD? The Possibilities of Misdiagnosis"

    ERIC Educational Resources Information Center

    Goerss, Jean; Amend, Edward R.; Webb, James T.; Webb, Nadia; Beljan, Paul

    2006-01-01

    The Hartnett, Nelson, and Rinn 2004 study indicates that diagnostic confusion between ADD/ADHD and giftedness exists, and that research on medication practices is warranted. Mika disagrees, saying that there is no empirical evidence of misdiagnosis of gifted children as having ADD/ADHD. We disagree with Mika's logic, and describe evidence that…

  2. "Passageless" administration of the Nelson-Denny Reading Comprehension Test: associations with IQ and reading skills.

    PubMed

    Ready, Rebecca E; Chaudhry, Maheen F; Schatz, Kelly C; Strazzullo, Sarah

    2013-01-01

    There are few tests that assess reading comprehension in adults, but these tests are needed for a comprehensive assessment of reading disorders (RD). The Nelson-Denny Reading Test (NDRT) has a long-passage reading comprehension component that can be used with adolescents and adults. A problem with the NDRT is that reading comprehension test items can be answered correctly without reading the associated passage. The current study determined how IQ, verbal comprehension, and reading skills were associated with scores on a passageless administration of the NDRT. Results indicated that IQ, verbal comprehension, and broad reading skills were significantly associated with greater NDRT passageless scores. Results raise questions about the validity of the reading comprehension component of the NDRT and suggest that the test may have differential validity based on individual differences in vocabulary, general fund of knowledge, and broad reading skills.

  3. Revisiting the Nelson-Morfey scaling law for flow noise from duct constrictions

    NASA Astrophysics Data System (ADS)

    Kårekull, Oscar; Efraimsson, Gunilla; Åbom, Mats

    2015-11-01

    The semi-empirical scaling law by Nelson and Morfey [1] predicts the noise generation from constrictions in ducts with low Mach number flows. The results presented here demonstrate that the original model loses accuracy for constrictions of high pressure loss. A generalization based on a momentum flux assumption of the dipole forces is suggested and is evaluated against measurement results for orifice geometries of higher pressure loss than earlier evaluated. A prediction model including constrictions at flow duct terminations is also suggested. Improved accuracy for the predictions of the new model is found for orifice geometries of high pressure loss inside and at the end of ducts. The extended model is finally evaluated by measurements on a regular ventilation air terminal device.

  4. Frustrated Lewis pairs: from concept to catalysis.

    PubMed

    Stephan, Douglas W

    2015-02-17

    CONSPECTUS: Frustrated Lewis pair (FLP) chemistry has emerged in the past decade as a strategy that enables main-group compounds to activate small molecules. This concept is based on the notion that combinations of Lewis acids and bases that are sterically prevented from forming classical Lewis acid-base adducts have Lewis acidity and basicity available for interaction with a third molecule. This concept has been applied to stoichiometric reactivity and then extended to catalysis. This Account describes three examples of such developments: hydrogenation, hydroamination, and CO2 reduction. The most dramatic finding from FLP chemistry was the discovery that FLPs can activate H2, thus countering the long-existing dogma that metals are required for such activation. This finding of stoichiometric reactivity was subsequently evolved to employ simple main-group species as catalysts in hydrogenations. While the initial studies focused on imines, subsequent studies uncovered FLP catalysts for a variety of organic substrates, including enamines, silyl enol ethers, olefins, and alkynes. Moreover, FLP reductions of aromatic anilines and N-heterocycles have been developed, while very recent extensions have uncovered the utility of FLP catalysts for ketone reductions. FLPs have also been shown to undergo stoichiometric reactivity with terminal alkynes. Typically, either deprotonation or FLP addition reaction products are observed, depending largely on the basicity of the Lewis base. While a variety of acid/base combinations have been exploited to afford a variety of zwitterionic products, this reactivity can also be extended to catalysis. When secondary aryl amines are employed, hydroamination of alkynes can be performed catalytically, providing a facile, metal-free route to enamines. In a similar fashion, initial studies of FLPs with CO2 demonstrated their ability to capture this greenhouse gas. Again, modification of the constituents of the FLP led to the discovery of reaction

  5. Nelson's syndrome: complete remission with cabergoline but not with bromocriptine or cyproheptadine treatment.

    PubMed

    Casulari, Luiz Augusto; Naves, Luciana A; Mello, Paulo A; Pereira Neto, Aldo; Papadia, Carla

    2004-01-01

    A woman affected by Cushing's disease underwent bilateral adrenalectomy followed by radiotherapy of the hypothalamic-pituitary area when she was 18 years old. Thereafter, she used hydrocortisone acetate replacement therapy (35.5 mg divided into two daily doses). At the age of 26 years, the patient exhibited the clinical signs of the Nelson's syndrome, i.e. skin and gingival hyperpigmentation accompanied by amenorrhea, and elevated ACTH plasma levels (2,850 pg/ml, normal range 15-80 pg/ml). The magnetic resonance imaging (MRI) analysis of the sellar region evidenced a pituitary macroadenoma, measuring 14 x 13 mm. The patient was initially treated with cyproheptadine hydrochloride (12 mg/day) for 18 months. There was a partial improvement of the symptoms, with a reduction of the ACTH plasma levels to 112 pg/ml, but without any modification of the tumor mass. Due to sleepiness and weight gain, the cyproheptadine treatment was interrupted and substituted by a cabergoline (0.5 mg twice a week) therapy. Soon after cabergoline was applied an improvement of the clinical symptoms and signs was observed such as a regression of the tumor mass and the normalization of the ACTH plasma titers (38 pg/ml). Later, cabergoline was substituted by bromocriptine (7.5 mg/day) and the plasma levels of ACTH increased again (247 pg/ml), and headache and cutaneous hyperpigmentation were recorded. When cabergoline was reintroduced there was a clinical improvement and normalization of ACTH plasma levels (64 pg/ml). The MRI analysis of the sella region demonstrated a complete remission of the pituitary adenoma. The results obtained show for the first time that a long-term treatment with cabergoline also brings about a complete remission of Nelson's syndrome in the presence of a pituitary macroadenoma.

  6. Identifying the tooth shade in group of patients using Vita Easyshade

    PubMed Central

    Elamin, Habab Osman; Abubakr, Neamat Hassan; Ibrahim, Yahia Eltayib

    2015-01-01

    Objective: The aim of the present investigation is to identify tooth shade among a group of Sudanese patients. Materials and Methods: Total number of patients was 227. Participant's age ranged from 15 to 72 years, which, was divided into four groups. The tooth included in the study was either right or left sounds maxillary central incisor. Vita Easyshade was used to select the tooth shade. Investigation of the differences of Commission International de l’Eclairage (CIELab) coordinates among gender and state of origin was conducted together with an examination of the relationship between CIELab coordinates and age. One-way analysis of variance was used to test the differences in L*, a* and b* according to state of origin. Results: Results showed that A3 was the most common classical tooth shade respectively. There was highly significant difference in L* between males and females (P = 0.002). There was a significant relation between tooth shade and age (P = 0.026). There was a high significant association between classical tooth shade and Sudan regions (P = 0.00). Conclusion: In conclusion, most common classical shade was A3, women's teeth were lighter than men's. There was a relation between ethnic background and tooth shade. PMID:26038652

  7. Thuja occidentalis (Arbor vitae): A Review of its Pharmaceutical, Pharmacological and Clinical Properties

    PubMed Central

    2005-01-01

    Arbor vitae (Thuja occidentalis L.) is a native European tree widely used in homeopathy and evidence-based phytotherapy. Many reviews and monographs have been published on the herbal substance's description, mode of action and clinical use. However, no comprehensive evidence-based review is available. Therefore, our aim was to search MEDLINE databases and survey manufacturers for further details or unpublished data. This review presents the botany, ethnobotany and phytochemistry, especially the different contents of essential oil (Thujone) in relation to different extraction procedures of this medicinal plant. Thuja's antiviral action and immunopharmacological potential, such as stimulatory and co-stimulatory effects on cytokine and antibody production and activation of macrophages and other immunocompetent cells, have been evaluated in numerous in vitro and in vivo investigations. Although no controlled trials have been conducted on Thuja occ alone, many clinical studies have been performed with a herbal medicinal product containing a special extract of Thuja occ and other immunostimulants, demonstrating its therapeutic efficacy and safety in respiratory tract infections. PMID:15841280

  8. Dementia with Lewy bodies: early diagnostic challenges.

    PubMed

    Fujishiro, Hiroshige; Iseki, Eizo; Nakamura, Shinichiro; Kasanuki, Koji; Chiba, Yuhei; Ota, Kazumi; Murayama, Norio; Sato, Kiyoshi

    2013-06-01

    Dementia with Lewy bodies (DLB) is defined pathologically as neurodegeneration associated with Lewy bodies (LB). LB-related symptoms, including olfactory dysfunction, dysautonomia, and mood and sleep disorders, are increasingly recognized as clinical signs that enable the early detection of DLB, because these symptoms often antedate dementia by years or even decades. It remains unknown if the clinical history of LB-related symptoms is sufficient for the prodromal state of DLB to be suspected in memory clinics. We retrospectively investigated the clinical courses, including olfactory dysfunction, dysautonomia, depression, and rapid eye movement sleep behaviour disorder, of 90 patients with probable DLB. The timing of LB-related symptoms that preceded or followed relative to the onset of memory loss was calculated. LB-related symptoms were present in 79 of 90 patients (87.8%) with probable DLB before or at the time of memory loss onset. These symptoms preceded the onset of memory loss between 1.2 and 9.3 years. We also report on four non-demented patients with a clinical history of LB-related symptoms in our memory clinic. All four patients showed reduced cardiac [(123) I]-metaiodobenzylguanidine levels. Moreover, [(18) F]fluoro-D-glucose positron emission tomography scans revealed glucose hypometabolism in the occipital cortex in two patients. One patient converted to probable DLB with the development of parkinsonism 2 years after major depression was diagnosed. Based on a clinical history of LB-related symptoms, we propose a conceptual framework to identify these symptomatic but non-demented individuals that led us to suspect the underlying pathophysiology of Lewy body disease. Further prospective study is warranted to determine the clinical significance of LB-related symptoms in non-demented patients.

  9. NASA Lewis Research Center Futuring Workshop

    NASA Technical Reports Server (NTRS)

    Boroush, Mark; Stover, John; Thomas, Charles

    1987-01-01

    On October 21 and 22, 1986, the Futures Group ran a two-day Futuring Workshop on the premises of NASA Lewis Research Center. The workshop had four main goals: to acquaint participants with the general history of technology forecasting; to familiarize participants with the range of forecasting methodologies; to acquaint participants with the range of applicability, strengths, and limitations of each method; and to offer participants some hands-on experience by working through both judgmental and quantitative case studies. Among the topics addressed during this workshop were: information sources; judgmental techniques; quantitative techniques; merger of judgment with quantitative measurement; data collection methods; and dealing with uncertainty.

  10. A zwitterionic carbanion frustrated by boranes--dihydrogen cleavage with weak Lewis acids via an "inverse" frustrated Lewis pair approach.

    PubMed

    Li, Hui; Aquino, Adelia J A; Cordes, David B; Hung-Low, Fernando; Hase, William L; Krempner, Clemens

    2013-10-30

    The synthesis, structural characterization, and acid-base chemistry of [C(SiMe2OCH2CH2OMe)3]Na (2), a sterically encumbered zwitterionic organosodium compound, is reported. 2 is a strong Brønsted base that forms frustrated Lewis pairs (FLPs) with a number of boron-containing Lewis acids ranging from weakly Lewis acidic aryl and alkyl boranes to various alkyl borates. These intermolecular FLPs readily cleave H2, which confirms that even poor Lewis acids can engage in FLP-mediated H2 cleavage provided that the present bulky base is of sufficiently high Brønsted basicity.

  11. Neurophysiological biomarkers for Lewy body dementias

    PubMed Central

    Cromarty, Ruth A.; Elder, Greg J.; Graziadio, Sara; Baker, Mark; Bonanni, Laura; Onofrj, Marco; O’Brien, John T.; Taylor, John-Paul

    2016-01-01

    Objective Lewy body dementias (LBD) include both dementia with Lewy bodies (DLB) and Parkinson’s disease with dementia (PDD), and the differentiation of LBD from other neurodegenerative dementias can be difficult. Currently, there are few biomarkers which might assist early diagnosis, map onto LBD symptom severity, and provide metrics of treatment response. Traditionally, biomarkers in LBD have focussed on neuroimaging modalities; however, as biomarkers need to be simple, inexpensive and non-invasive, neurophysiological approaches might also be useful as LBD biomarkers. Methods In this review, we searched PubMED and PsycINFO databases in a semi-systematic manner in order to identify potential neurophysiological biomarkers in the LBDs. Results We identified 1491 studies; of these, 37 studies specifically examined neurophysiological biomarkers in LBD patients. We found that there was substantial heterogeneity with respect to methodologies and patient cohorts. Conclusion Generally, many of the findings have yet to be replicated, although preliminary findings reinforce the potential utility of approaches such as quantitative electroencephalography and motor cortical stimulation paradigms. Significance Various neurophysiological techniques have the potential to be useful biomarkers in the LBDs. We recommend that future studies focus on maximising the diagnostic specificity and sensitivity of the most promising neurophysiological biomarkers. PMID:26183755

  12. Nelson's syndrome: single centre experience using the linear accelerator (LINAC) for stereotactic radiosurgery and fractionated stereotactic radiotherapy.

    PubMed

    Wilson, Peter J; Williams, Janet R; Smee, Robert I

    2014-09-01

    Nelson's syndrome is a unique clinical phenomenon of growth of a pituitary adenoma following bilateral adrenalectomies for the control of Cushing's disease. Primary management is surgical, with limited effective medical therapies available. We report our own institution's series of this pathology managed with radiation: prior to 1990, 12 patients were managed with conventional radiotherapy, and between 1990 and 2007, five patients underwent stereotactic radiosurgery (SRS) and two patients fractionated stereotactic radiotherapy (FSRT), both using the linear accelerator (LINAC). Tumour control was equivocal, with two of the five SRS patients having a reduction in tumour volume, one patient remaining unchanged, and two patients having an increase in volume. In the FSRT group, one patient had a decrease in tumour volume whilst the other had an increase in volume. Treatment related morbidity was low. Nelson's syndrome is a challenging clinical scenario, with a highly variable response to radiation in our series.

  13. 32 CFR 552.168 - Fort Lewis Area Access Office.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 32 National Defense 3 2014-07-01 2014-07-01 false Fort Lewis Area Access Office. 552.168 Section 552.168 National Defense Department of Defense (Continued) DEPARTMENT OF THE ARMY MILITARY..., Yakima Training Center, and Camp Bonneville § 552.168 Fort Lewis Area Access Office. (a) DPTM...

  14. 32 CFR 552.168 - Fort Lewis Area Access Office.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 32 National Defense 3 2010-07-01 2010-07-01 true Fort Lewis Area Access Office. 552.168 Section 552.168 National Defense Department of Defense (Continued) DEPARTMENT OF THE ARMY MILITARY..., Yakima Training Center, and Camp Bonneville § 552.168 Fort Lewis Area Access Office. (a) DPTM...

  15. 32 CFR 552.168 - Fort Lewis Area Access Office.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 32 National Defense 3 2012-07-01 2009-07-01 true Fort Lewis Area Access Office. 552.168 Section 552.168 National Defense Department of Defense (Continued) DEPARTMENT OF THE ARMY MILITARY..., Yakima Training Center, and Camp Bonneville § 552.168 Fort Lewis Area Access Office. (a) DPTM...

  16. Interview with Smithsonian NASM Spacesuit Curator Dr. Cathleen Lewis

    NASA Technical Reports Server (NTRS)

    Lewis, Cathleen; Wright, Rebecca

    2012-01-01

    Dr. Cathleen Lewis was interviewed by Rebecca Wright during the presentation of an "Interview with Smithsonian NASM Spacesuit Curator Dr. Cathleen Lewis" on May 14, 2012. Topics included the care, size, and history of the spacesuit collection at the Smithsonian and the recent move to the state-of-the-art permanent storage facility at the Udvar-Hazy facility in Virginia.

  17. 32 CFR 552.168 - Fort Lewis Area Access Office.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... RESERVATIONS AND NATIONAL CEMETERIES REGULATIONS AFFECTING MILITARY RESERVATIONS Land Use Policy for Fort Lewis, Yakima Training Center, and Camp Bonneville § 552.168 Fort Lewis Area Access Office. (a) DPTM Range Division operates the Area Access Section to issue permits and grant non-training access to the...

  18. 32 CFR 552.168 - Fort Lewis Area Access Office.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... RESERVATIONS AND NATIONAL CEMETERIES REGULATIONS AFFECTING MILITARY RESERVATIONS Land Use Policy for Fort Lewis, Yakima Training Center, and Camp Bonneville § 552.168 Fort Lewis Area Access Office. (a) DPTM Range Division operates the Area Access Section to issue permits and grant non-training access to the...

  19. Impairments of Speech Fluency in Lewy Body Spectrum Disorder

    ERIC Educational Resources Information Center

    Ash, Sharon; McMillan, Corey; Gross, Rachel G.; Cook, Philip; Gunawardena, Delani; Morgan, Brianna; Boller, Ashley; Siderowf, Andrew; Grossman, Murray

    2012-01-01

    Few studies have examined connected speech in demented and non-demented patients with Parkinson's disease (PD). We assessed the speech production of 35 patients with Lewy body spectrum disorder (LBSD), including non-demented PD patients, patients with PD dementia (PDD), and patients with dementia with Lewy bodies (DLB), in a semi-structured…

  20. The Organization of Narrative Discourse in Lewy Body Spectrum Disorder

    ERIC Educational Resources Information Center

    Ash, Sharon; McMillan, Corey; Gross, Rachel G.; Cook, Philip; Morgan, Brianna; Boller, Ashley; Dreyfuss, Michael; Siderowf, Andrew; Grossman, Murray

    2011-01-01

    Narrative discourse is an essential component of day-to-day communication, but little is known about narrative in Lewy body spectrum disorder (LBSD), including Parkinson's disease (PD), Parkinson's disease with dementia (PDD), and dementia with Lewy bodies (DLB). We performed a detailed analysis of a semi-structured speech sample in 32 non-aphasic…

  1. Difficulty Processing Temporary Syntactic Ambiguities in Lewy Body Spectrum Disorder

    ERIC Educational Resources Information Center

    Grossman, Murray; Gross, Rachel G.; Moore, Peachie; Dreyfuss, Michael; McMillan, Corey T.; Cook, Philip A.; Ash, Sherry; Siderowf, Andrew

    2012-01-01

    While grammatical aspects of language are preserved, executive deficits are prominent in Lewy body spectrum disorder (LBSD), including Parkinson's disease (PD), Parkinson's dementia (PDD) and dementia with Lewy bodies (DLB). We examined executive control during sentence processing in LBSD by assessing temporary structural ambiguities. Using an…

  2. New entries to water-compatible Lewis acids.

    PubMed

    Kobayashi, Shu; Ogawa, Chikako

    2006-08-07

    Lewis acid catalysis has attracted much attention in organic synthesis as it often affords access to unique reactivity and selectivity under mild conditions. Although various kinds of Lewis acids have been developed and applied in industry, these Lewis acids must be generally used under strictly anhydrous conditions, as the presence of even a small amount of water interferes with the reactions due to preferential reaction of the Lewis acids with water rather than the substrates. In contrast to this, rare earth and other metal complexes have been found to be water-compatible. Furthermore, Bi(OTf)(3)- and Ga(OTf)(3)-basic ligand complexes have also been found to be stable in water, and have been used as water-compatible Lewis acids. This application is particularly significant, as Bi(OTf)(3) and Ga(OTf)(3) themselves are unstable in the presence of water, but are stabilized by the basic ligands. This observation has led to the development of a new approach to Lewis acid catalysis in which Lewis acids that are generally unstable in the presence of water are rendered amenable to aqueous systems when combined with basic ligands. In particular, the use of chiral basic ligands leading to new types of water-compatible chiral Lewis acids may enable a wide range of asymmetric catalysis in aqueous media.

  3. Thoughts on Teaching: John L. Lewis, Jesus, and President Bush.

    ERIC Educational Resources Information Center

    Starnes, Bobby Ann

    2004-01-01

    Bobby Ann Starnes, the author of this article, grew up with portraits of two important people displayed prominently in her home, Jesus, and John L. Lewis. Lewis, a giant among American leaders in the first half of the twentieth century, sent hundreds of organizers to help create some of the nation's leading labor unions, including the United…

  4. Lewis morris rutherfurd 1816-1892.

    PubMed

    Devons, S

    1976-07-01

    Lewis M. Rutherfurd (1816-1892) was a wealthy amateur practitioner of science, making notable contributions to the optics of astronomy and spectroscopy. He graduated from Williams College at the age of 18 and soon began a career in law. Not long thereafter he was fortunate enough to acquire sufficient wealth through marriage to permit him to pursue scientific activity, for which he had gained interest. He soon became interested in photographing the heavens to obtain quantitative data regarding star motions. A few years later he developed a spectrometer with which he obtained some of the best attainable stellar spectra of the time. Rutherfurd is not widely known because he did not fully report his work; but through correspondence and instrument development he had a profound influence on his contemporaries. He was made a trustee of Columbia College in 1858, and in 1881 he helped to found a department of Geodesy and Practical Astronomy there.

  5. Aluminium Diphosphamethanides: Hidden Frustrated Lewis Pairs.

    PubMed

    Styra, Steffen; Radius, Michael; Moos, Eric; Bihlmeier, Angela; Breher, Frank

    2016-07-04

    The synthesis and characterisation of two aluminium diphosphamethanide complexes, [Al(tBu)2 {κ(2) P,P'-Mes*PCHPMes*}] (3) and [Al(C6 F5 )2 {κ(2) P,P'-Mes*PCHPMes*}] (4), and the silylated analogue, Mes*PCHP(SiMe3 )Mes* (5), are reported. The aluminium complexes feature four-membered PCPAl core structures consisting of diphosphaallyl ligands. The silylated phosphine 5 was found to be a valuable precursor for the synthesis of 4 as it cleanly reacts with the diaryl aluminium chloride [(C6 F5 )2 AlCl]2 . The aluminium complex 3 reacts with molecular dihydrogen at room temperature under formation of the acyclic σ(2) λ(3) ,σ(3) λ(3) -diphosphine Mes*PCHP(H)Mes* and the corresponding dialkyl aluminium hydride [tBu2 AlH]3 . Thus, 3 belongs to the family of so-called hidden frustrated Lewis pairs.

  6. Superconducting Microwave Electronics at Lewis Research Center

    NASA Technical Reports Server (NTRS)

    Warner, Joseph D.; Bhasin, Kul B.; Leonard, Regis F.

    1991-01-01

    Over the last three years, NASA Lewis Research Center has investigated the application of newly discovered high temperature superconductors to microwave electronics. Using thin films of YBa2Cu3O7-delta and Tl2Ca2Ba2Cu3Ox deposited on a variety of substrates, including strontium titanate, lanthanum gallate, lanthanum aluminate and magnesium oxide, a number of microwave circuits have been fabricated and evaluated. These include a cavity resonator at 60 GHz, microstrip resonators at 35 GHz, a superconducting antenna array at 35 GHz, a dielectric resonator at 9 GHz, and a microstrip filter at 5 GHz. Performance of some of these circuits as well as suggestions for other applications are reported.

  7. Dementia with Lewy bodies: current concepts.

    PubMed

    Buracchio, Teresa; Arvanitakis, Zoe; Gorbien, Martin

    2005-01-01

    As life expectancy continues to increase over time, dementia is becoming an increasingly more common problem and a major cause of disability in older persons. It is now more important than ever to identify and manage common causes of dementia given variations in disease course, treatments and the possibility for modification of risk factors. Dementia with Lewy bodies (DLB) is a dementia syndrome characterized by progressive cognitive decline, with fluctuating cognition, recurrent detailed and well-formed hallucinations, and parkinsonism. This article aims to provide an overview of current concepts of DLB, including a description of the key clinical features and neuropathology, neurochemistry, and genetics of DLB, then a discussion of the relationship of DLB with Alzheimer's disease and Parkinson's disease, and, finally, a summary of current management strategies available for this disorder.

  8. Tips for a physician in getting the right job, part II: the curriculum vitae, cover letter, and personal statement.

    PubMed

    Harolds, Jay A

    2013-09-01

    It is very important that a job seeker prepares an excellent curriculum vitae (CV) and cover letter. Often a personal statement is also needed. If these are not done well, often an interview is not granted. There are different formats and headings for the CV, depending on the type of job sought and the institution the job is located in. There are also some differences in how this is done between different countries. However, there are also many common elements of a proper CV.

  9. Large Lewis No. Edge-Flame Instabilities

    NASA Technical Reports Server (NTRS)

    Buckmaster, J.

    2001-01-01

    Edge-flames play an important role in a number of microgravity investigations, and in the general study of flames. Examples include the candle-flame experiments carried out on board both the Space Shuttle and the Mir Space Station; the flame-spread-over-liquid work carried out by H. Ross and W. Sirignano amongst others and lifted turbulent diffusion flames. In all of these configurations a local two-dimensional flame structure can be identified which looks like a flame-sheet with an edge, and these structures exhibit dynamical behavior which characterizes them and distinguishes them from ad hoc 2D flame structures. Edge-flames can exist in both a non-premixed context (edges of diffusion flames) and in a premixed context (edges of deflagrations), but the work reported here deals with the edges of diffusion flames. It is particularly relevant, we believe, to oscillations that have been seen in both the candle-flame context, and the flame-spread-over-liquid context. These oscillations are periodic edge-oscillations (in an appropriate reference frame), sans oscillation of the trailing diffusion flame. It is shown that if the Lewis number of the fuel is sufficiently large (the Lewis number of the oxidizer is taken to be 1), and the Damkohler number is sufficiently small, oscillating-edge solutions can be found. Oscillations are encouraged by an on-edge convective flow and the insertion of a cold probe, discouraged by an off-edge convective flow. In the present work, the nature of these oscillations is examined in more depth, using a variety of numerical strategies.

  10. Chiral organoborane Lewis pairs derived from pyridylferrocene.

    PubMed

    Chen, Jiawei; Lalancette, Roger A; Jäkle, Frieder

    2014-07-14

    In an effort to develop a new class of redox-active chiral Lewis pairs, pyridine and borane moieties with different steric and electronic properties were introduced onto a planar chiral 1,2-disubstituted ferrocene framework. Metathesis of lithiated, stannylated, or mercuriated pyridylferrocenes with boron halides afforded (pR)-2-[bis(pentafluorophenyl)boryl]-1-(3,5-dimethylpyrid-2-yl)ferrocene (4-Pf), (pR)-2-[dimesitylboryl]-1-(3,5-dimethylpyrid-2-yl)ferrocene (4-Mes), (pS)-2-(bis(pentafluorophenyl)boryl)-1-(2-trimethylsilylpyrid-6-yl)ferrocene (5-Pf), or (pS)-2-[dimesitylboryl]-1-(2-trimethylsilylpyrid-6-yl)ferrocene (5-Mes). The borylated products were analyzed by multinuclear NMR spectroscopy, HRMS, and single-crystal X-ray diffraction. Chiral HPLC and optical-rotation measurements were employed to assess the stereoselectivity of the borylation process and to establish the correct stereochemical assignments. The strength of the B-N interactions were investigated in solution and in the solid state. Compounds 4-Pf and 4-Mes formed robust 'closed' B-N heterocyclic systems that proved to be perfectly stable to air and moisture, whereas 5-Pf established a dynamic equilibrium, in which the B-N heterocycle was observed exclusively at room temperature, but opened up at high temperature according to (19)F NMR exchange spectroscopy data. As a consequence, 5-Pf reacted readily with a molecule of water to generate a ring-opened pyridinium borate. The combination of bulky borane and bulky pyridyl groups in 5-Mes led to a completely 'open' frustrated Lewis pair system with uncomplexed pyridine and borane groups, even at room temperature. Electrochemical studies were performed and the effect of preparative ferrocene oxidation on the structural features was also explored.

  11. Parkinson disease and incidental Lewy body disease

    PubMed Central

    Geraci-Erck, Maria; Rabin, Marcie L.; Adler, Charles H.; Serrano, Geidy; Beach, Thomas G.; Kurlan, Roger

    2015-01-01

    Objective: To quantify the loss of pigmented neurons in the substantia nigra (SN) of autopsy-confirmed Parkinson disease (PD) and incidental Lewy body disease (ILBD) vs age-matched controls (C). Methods: Unbiased stereology methods were used to rigorously count number and measure volumes of nigral pigmented neurons in PD, ILBD, and C brains. The obtained stereologic results were correlated with Lewy body (LB), amyloid plaque (AP), neurofibrillary tangle (NFT), and vascular pathology loads assessed in nigral and extranigral regions of each PD, ILBD, and C brain. The stereologic measurements were also correlated to predeath motor and cognitive scores as available for each participant. Results: A marked nigral neuronal loss (NNL) in PD (−82%) and ILBD (−40%) compared to C (p < 0.0001) was found. While there was significant correlation between NNL and LB in some cortical areas of PD (i.e., olfactory bulb), there were no correlations between NNL and LB, AP, or NFT loads or cerebral infarct volumes in any other examined regions for PD and ILBD brains. Conclusions: Using unbiased stereology methods, we show that there is a significant loss and absence of hypertrophic changes in nigral pigmented neurons of ILBD in comparison to C brains. Intriguingly, no significant correlations were found between NNL and LB loads in the SN of both PD and ILBD brains. These autopsy-verified stereologically based findings are novel and support ILBD as a pathologic condition. These results suggest possible new and alternative pathophysiologic hypotheses on the actual relationship between NNL and LB pathology. PMID:26468408

  12. Incidental Lewy Body Disease: Electrophysiological Findings Suggesting Pre-clinical Lewy Body Disorders

    PubMed Central

    Caviness, John N.; Adler, Charles H.; Hentz, Joseph G.; Shill, Holly A.; Evidente, Virgilio G.H.; Driver-Dunckley, Erika D.; Sabbagh, Marwan N.; Sue, Lucia; Beach, Thomas G.

    2011-01-01

    Objective Evaluate electrophysiologic findings in incidental Lewy Body disease (ILBD). Methods ILBD, Control, and Parkinson's disease (PD) subjects had electrophysiological evaluation within two years prior to autopsy. Data analyzed included surface electromyography (EMG) of upper extremity muscles during rest and muscle activation, and electroencephalography (EEG) recording at rest. For EMG, gross tracings and spectral peaks were analyzed. EEG measures analyzed were background frequency and power in delta, theta, alpha, and beta bands. Results Three of ten ILBD subjects (30%) showed unilateral rhythmic EMG discharges at rest without a visually apparent rest tremor. The ILBD resting EMG frequency was lower than in the Control group with no overlap (P=0.03) and close to that of the PD group. The ILBD group had significantly lower background rhythm frequency than the Control group (P=0.001) but was greater than the PD group (P=0.01). Conclusions The electrophysiologic changes in ILBD cases are between those of Control and PD, suggesting that these findings may reflect changes correlating with ILBD as a possible precursor to PD. Significance Electrophysiologic changes in ILBD may assist with the identification of a preclinical stage for Lewy body disorders and help the development of a therapeutic agent for modifying Lewy body disease progression. PMID:21616709

  13. Accuracy of shade matching performed by colour blind and normal dental students using 3D Master and Vita Lumin shade guides.

    PubMed

    Vafaee, F; Rakhshan, V; Vafaei, M; Khoshhal, M

    2012-03-01

    The purpose of this study was to investigate whether 3D Master or VitaLumin shade guides could improve colour selection in individuals with normal and defective colour vision. First, colour perception of 260 dental students was evaluated. Afterwards, 9 colour blind and 9 matched normal subjects tried to detect colours of 10 randomly selected tabs from each kit and the correct/false answers were counted. Of the colour-defective subjects, 47.8% and 33.3% correctly detected the shade using 3D Master and VitaLumin, respectively. These statistics were 62.2% and 42.2% in normal subjects. In normal participants, but not in colour blind ones, 3D Master significantly improved shade matching accuracy compared to VitaLumin.

  14. Lewis Acid-Base, Molecular Modeling, and Isotopic Labeling in a Sophomore Inorganic Chemistry Laboratory

    ERIC Educational Resources Information Center

    Nataro, Chip; Ferguson, Michelle A.; Bocage, Katherine M.; Hess, Brian J.; Ross, Vincent J.; Swarr, Daniel T.

    2004-01-01

    An experiment to prepare a deuterium labeled adduct of a Lewis acid and Lewis base, to use computational methods allowing students to visualize the LUMO of Lewis acids, the HOMO of Lewis bases and the molecular orbitals of the adduct that is formed is developed. This allows students to see the interplay between calculated and experimental results.

  15. Is It Lewy Body Dementia or Something Else?

    MedlinePlus

    ... Options Join the fight against LBD! Donate Is It LBD or Something Else? Early and accurate diagnosis ... dementia with Lewy bodies’ (DLB). Symptoms that differentiate it from Alzheimer’s include unpredictable levels of cognitive ability, ...

  16. FEATURE B. MACHINE GUN POSITION WITH LEWIS MOUNT, VIEW FACING ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    FEATURE B. MACHINE GUN POSITION WITH LEWIS MOUNT, VIEW FACING NORTHWEST (with scale stick). - Naval Air Station Barbers Point, Battery-Machine Gun Positions, South of Point Cruz Road & west of Coral Sea Road, Ewa, Honolulu County, HI

  17. FEATURE B. MACHINE GUN POSITION WITH LEWIS MOUNT, VIEW FACING ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    FEATURE B. MACHINE GUN POSITION WITH LEWIS MOUNT, VIEW FACING NORTHWEST. - Naval Air Station Barbers Point, Battery-Machine Gun Positions, South of Point Cruz Road & west of Coral Sea Road, Ewa, Honolulu County, HI

  18. Distance Learning With NASA Lewis Research Center's Learning Technologies Project

    NASA Technical Reports Server (NTRS)

    Petersen, Ruth

    1998-01-01

    The NASA Lewis Research Center's Learning Technologies Project (LTP) has responded to requests from local school district technology coordinators to provide content for videoconferencing workshops. Over the past year we have offered three teacher professional development workshops that showcase NASA Lewis-developed educational products and NASA educational Internet sites. In order to determine the direction of our involvement with distance learning, the LTP staff conducted a survey of 500 U.S. schools. We received responses from 72 schools that either currently use distance learning or will be using distance learning in 98-99 school year. The results of the survey are summarized in the article. In addition, the article provides information on distance learners, distance learning technologies, and the NASA Lewis LTP videoconferencing workshops. The LTP staff will continue to offer teacher development workshops through videoconferencing during the 98-99 school year. We hope to add workshops on new educational products as they are developed at NASA Lewis.

  19. 123I-Metaiodobenzylguanidine Myocardial Scintigraphy in Lewy Body-Related Disorders: A Literature Review

    PubMed Central

    Chung, Eun Joo; Kim, Sang Jin

    2015-01-01

    Lewy body-related disorders are characterized by the presence of Lewy bodies and Lewy neurites, which have abnormal aggregations of α-synuclein in the nigral and extranigral areas, including in the heart. 123I-metaiodobenzylguanidine (MIBG) scintigraphy is a well-known tool to evaluate cardiac sympathetic denervation in the Lewy body-related disorders. MIBG scintigraphy showed low uptake of MIBG in the Lewy body-related disorders, including Parkinson’s disease, dementia with Lewy bodies, pure autonomic failure and rapid eye movement sleep behavior disorder. This review summarizes previous results on the diagnostic applications of MIBG scintigraphy in Lewy body-related disorders. PMID:26090077

  20. Chemistry and Electrochemistry in Lewis Acid and Superacid Ionic Liquids

    DTIC Science & Technology

    1994-04-30

    LEWIS ACID AND SUPERACID IONIC LIQUIDS PRINCIPAL INVESTIGATOR: Dr. Robert A. Osteryoung Department of Chemistry North Carolina State University...Spectroscopic Study of Anthracene in a Mixed Lewis-Bronsted Acid Ambient Temperature Molten Salt System", Electrochim. Acta, 37, 2615-2628 (1992...investigated. In acidic melts, electrochemical oxidation of anthracene produces a cation radical which exhibits stability similar to that found in "Msuperdry

  1. Lewis Research Center space station electric power system test facilities

    NASA Technical Reports Server (NTRS)

    Birchenough, Arthur G.; Martin, Donald F.

    1988-01-01

    NASA Lewis Research Center facilities were developed to support testing of the Space Station Electric Power System. The capabilities and plans for these facilities are described. The three facilities which are required in the Phase C/D testing, the Power Systems Facility, the Space Power Facility, and the EPS Simulation Lab, are described in detail. The responsibilities of NASA Lewis and outside groups in conducting tests are also discussed.

  2. NASA Lewis Stirling engine computer code evaluation

    SciTech Connect

    Sullivan, T.J.

    1989-01-01

    In support of the US Department of Energy's Stirling Engine Highway Vehicle Systems program, the NASA Lewis Stirling engine performance code was evaluated by comparing code predictions without engine-specific calibration factors to GPU-3, P-40, and RE-1000 Stirling engine test data. The error in predicting power output was /minus/11 percent for the P-40 and 12 percent for the RE-1000 at design conditions and 16 percent for the GPU-3 at near-design conditions (2000 rpm engine speed versus 3000 rpm at design). The efficiency and heat input predictions showed better agreement with engine test data than did the power predictions. Concerning all data points, the error in predicting the GPU-3 brake power was significantly larger than for the other engines and was mainly a result of inaccuracy in predicting the pressure phase angle. Analysis into this pressure phase angle prediction error suggested that improvement to the cylinder hysteresis loss model could have a significant effect on overall Stirling engine performance predictions. 13 refs., 26 figs., 3 tabs.

  3. False memories in Lewy-body disease.

    PubMed

    Algarabel, Salvador; Pitarque, Alfonso; Sales, Alicia; Meléndez, Juan Carlos; Escudero, Joaquín

    2015-12-01

    Recently, de Boysson, Belleville, Phillips et al. (2011) found that patients with Lewy-body disease (LBD) showed significantly lower rates of false memories than healthy controls, using the Deese-Roediger-McDermott (DRM) experimental procedure. Given that this result could be explained by the practically null rate of true recognition in the LBD group (0.09), we decided to replicate the study by de Boysson et al. (2011), but including a new condition that would maximize the true recognition rate (and analyze its effect on the rate of false memories). Specifically, in a DRM experiment, we manipulated (within subjects) two study and recognition conditions: in the "immediate" condition, both the LBD patients and the control group of healthy older people received a different recognition test after each study list (containing twelve words associated with a non-presented critical word), while in the "delayed" condition (similar to the one in de Boysson et al., 2011), the participants received the entire series of study lists and then took only one recognition test. The results showed that, in both samples, the "immediate" condition produced higher corrected rates of both true and false recognition than the "delayed" condition, although they were both lower in the LBD patients, which shows that these patients are capable of encoding and recognizing the general similitude underlying information (gist memory) in the right conditions.

  4. ISDN at NASA Lewis Research Center

    NASA Technical Reports Server (NTRS)

    Bakes, Catherine Murphy; Goldberg, Fredric; Eubanks, Steven W.

    1992-01-01

    An expository investigation of the potential impact of the Integrated Services Digital Network (ISDN) at NASA Lewis Research Center is described. To properly frame the subject, the paper contains a detailed survey of the components of Narrowband ISDN. The principles and objectives are presented as decreed by the Consultative Committee for International Telephone and Telegraph (CCITT). The various channel types are delineated and their associated service combinations are described. The subscriber-access network functions are explained pictorially via the ISDN reference configuration. A section on switching techniques is presented to enable the reader to understand the emergence of the concept of fast packet switching. This new technology is designed to operate over the high bandwidth, low error rate transmission media that characterizes the LeRC environment. A brief introduction to the next generation of networks is covered with sections on Broadband ISDM (B-ISDN), Asynchronous Transfer Mode (ATM), and Synchronous Optical Networks (SONET). Applications at LeRC are presented, first in terms of targets of opportunity, then in light of compatibility constraints. In-place pilot projects and testing are described that demonstrate actual usage at LeRC.

  5. Lewis Research Center R and D Facilities

    NASA Technical Reports Server (NTRS)

    1991-01-01

    The NASA Lewis Research Center (LeRC) defines and develops advanced technology for high priority national needs. The work of the Center is directed toward new propulsion, power, and communications technologies for application to aeronautics and space, so that U.S. leadership in these areas is ensured. The end product is knowledge, usually in a report, that is made fully available to potential users--the aircraft engine industry, the energy industry, the automotive industry, the space industry, and other NASA centers. In addition to offices and laboratories for almost every kind of physical research in such fields as fluid mechanics, physics, materials, fuels, combustion, thermodynamics, lubrication, heat transfer, and electronics, LeRC has a variety of engineering test cells for experiments with components such as compressors, pumps, conductors, turbines, nozzles, and controls. A number of large facilities can simulate the operating environment for a complete system: altitude chambers for aircraft engines; large supersonic wind tunnels for advanced airframes and propulsion systems; space simulation chambers for electric rockets or spacecraft; and a 420-foot-deep zero-gravity facility for microgravity experiments. Some problems are amenable to detection and solution only in the complete system and at essentially full scale. By combining basic research in pertinent disciplines and generic technologies with applied research on components and complete systems, LeRC has become one of the most productive centers in its field in the world. This brochure describes a number of the facilities that provide LeRC with its exceptional capabilities.

  6. NASA Lewis Stirling engine computer code evaluation

    NASA Technical Reports Server (NTRS)

    Sullivan, Timothy J.

    1989-01-01

    In support of the U.S. Department of Energy's Stirling Engine Highway Vehicle Systems program, the NASA Lewis Stirling engine performance code was evaluated by comparing code predictions without engine-specific calibration factors to GPU-3, P-40, and RE-1000 Stirling engine test data. The error in predicting power output was -11 percent for the P-40 and 12 percent for the Re-1000 at design conditions and 16 percent for the GPU-3 at near-design conditions (2000 rpm engine speed versus 3000 rpm at design). The efficiency and heat input predictions showed better agreement with engine test data than did the power predictions. Concerning all data points, the error in predicting the GPU-3 brake power was significantly larger than for the other engines and was mainly a result of inaccuracy in predicting the pressure phase angle. Analysis into this pressure phase angle prediction error suggested that improvements to the cylinder hysteresis loss model could have a significant effect on overall Stirling engine performance predictions.

  7. DatSCAN In Differential Diagnostics of Lewy Body Disease.

    PubMed

    Luzny, Jan; Ivanova, Katerina

    2016-06-01

    Differential diagnosis between Lewy body disease and Alzheimer´s disease might be difficult because of similarities of clinical symptoms in both neurodegenerative diseases. DatSCAN is a modern functional neuroimmaging method which differentiates between this similar diseases and helps in correct treatment strategy. We report our positive experience with DatSCAN in differentiating Lewy body disease from Alzheimer´s disease. This is a case report of a woman with Lewy body disease, initially diagnosed as Alzheimer´s disease. DatSCAN neuroimmaging method was used in differential diagnosis of dementia. Memory impairment, impaired activities of daily living, sleep and behavioral disturbances were present in our case. Donepezil was well tolerated, but haloperidol administration was followed by development of severe dystonia. DatSCAN showed deficient dopaminergic presynaptic transport in substantia nigra and striatum. This finding is typical for Lewy body disease not for Alzheimer´s disease. DatSCAN neuroimmaging is a suitable method for differentiating Lewy body disease from Alzheimer´s disease. Deficient dopaminergic presynaptic transport in substantia nigra and striatum is typical for Lewy body disease.

  8. Global Climate Model Simulated Hydrologic Droughts and Floods in the Nelson-Churchill Watershed

    NASA Astrophysics Data System (ADS)

    Vieira, M. J. F.; Stadnyk, T. A.; Koenig, K. A.

    2014-12-01

    There is uncertainty surrounding the duration, magnitude and frequency of historical hydroclimatic extremes such as hydrologic droughts and floods prior to the observed record. In regions where paleoclimatic studies are less reliable, Global Climate Models (GCMs) can provide useful information about past hydroclimatic conditions. This study evaluates the use of Coupled Model Intercomparison Project 5 (CMIP5) GCMs to enhance the understanding of historical droughts and floods across the Canadian Prairie region in the Nelson-Churchill Watershed (NCW). The NCW is approximately 1.4 million km2 in size and drains into Hudson Bay in Northern Manitoba, Canada. One hundred years of observed hydrologic records show extended dry and wet periods in this region; however paleoclimatic studies suggest that longer, more severe droughts have occurred in the past. In Manitoba, where hydropower is the primary source of electricity, droughts are of particular interest as they are important for future resource planning. Twenty-three GCMs with daily runoff are evaluated using 16 metrics for skill in reproducing historic annual runoff patterns. A common 56-year historic period of 1950-2005 is used for this evaluation to capture wet and dry periods. GCM runoff is then routed at a grid resolution of 0.25° using the WATFLOOD hydrological model storage-routing algorithm to develop streamflow scenarios. Reservoir operation is naturalized and a consistent temperature scenario is used to determine ice-on and ice-off conditions. These streamflow simulations are compared with the historic record to remove bias using quantile mapping of empirical distribution functions. GCM runoff data from pre-industrial and future projection experiments are also bias corrected to obtain extended streamflow simulations. GCM streamflow simulations of more than 650 years include a stationary (pre-industrial) period and future periods forced by radiative forcing scenarios. Quantile mapping adjusts for magnitude

  9. Lewis base activation of Lewis acids: catalytic, enantioselective vinylogous aldol addition reactions.

    PubMed

    Denmark, Scott E; Heemstra, John R

    2007-07-20

    The generality of Lewis base catalyzed, Lewis acid mediated, enantioselective vinylogous aldol addition reactions has been investigated. The combination of silicon tetrachloride and chiral phosphoramides is a competent catalyst for highly selective additions of a variety of alpha,beta-unsaturated ketone-, 1,3-diketone-, and alpha,beta-unsaturated amide-derived dienolates to aldehydes. These reactions provided high levels of gamma-site selectivity for a variety of substitution patterns on the dienyl unit. Both ketone- and morpholine amide-derived dienol ethers afforded high enantio- and diastereoselectivity in the addition to conjugated aldehydes. Although alpha,beta-unsaturated ketone-derived dienolate did not react with aliphatic aldehydes, alpha,beta-unsaturated amide-derived dienolates underwent addition at reasonable rates affording high yields of vinylogous aldol product. The enantioselectivities achieved with the morpholine derived-dienolate in the addition to aliphatic aldehydes was the highest afforded to date with the silicon tetrachloride-chiral phosphoramide system. Furthermore, the ability to cleanly convert the morpholine amide to a methyl ketone was demonstrated.

  10. Selectin Ligands Sialyl-Lewis a and Sialyl-Lewis x in Gastrointestinal Cancers

    PubMed Central

    Trinchera, Marco; Aronica, Adele; Dall’Olio, Fabio

    2017-01-01

    The tetrasaccharide structures Siaα2,3Galβ1,3(Fucα1,4)GlcNAc and Siaα2,3Galβ1,4(Fucα1,3)GlcNAc constitute the epitopes of the carbohydrate antigens sialyl-Lewis a (sLea) and sialyl-Lewis x (sLex), respectively, and are the minimal requirement for selectin binding to their counter-receptors. Interaction of sLex expressed on the cell surface of leucocytes with E-selectin on endothelial cells allows their arrest and promotes their extravasation. Similarly, the rolling of cancer cells ectopically expressing the selectin ligands on endothelial cells is potentially a crucial step favoring the metastatic process. In this review, we focus on the biosynthetic steps giving rise to selectin ligand expression in cell lines and native tissues of gastrointestinal origin, trying to understand whether and how they are deregulated in cancer. We also discuss the use of such molecules in the diagnosis of gastrointestinal cancers, particularly in light of recent data questioning the ability of colon cancers to express sLea and the possible use of circulating sLex in the early detection of pancreatic cancer. Finally, we reviewed the data dealing with the mechanisms that link selectin ligand expression in gastrointestinal cells to cancer malignancy. This promising research field seems to require additional data on native patient tissues to reach more definitive conclusions. PMID:28241499

  11. Neuroimaging characteristics of dementia with Lewy bodies.

    PubMed

    Mak, Elijah; Su, Li; Williams, Guy B; O'Brien, John T

    2014-01-01

    This review summarises the findings and applications from neuroimaging studies in dementia with Lewy bodies (DLB), highlighting key differences between DLB and other subtypes of dementia. We also discuss the increasingly important role of imaging biomarkers in differential diagnosis and outline promising areas for future research in DLB. DLB shares common clinical, neuropsychological and pathological features with Parkinson's disease dementia and other dementia subtypes, such as Alzheimer's disease. Despite the development of consensus diagnostic criteria, the sensitivity for differential diagnosis of DLB in clinical practice remains low and many DLB patients will be misdiagnosed. The importance of developing accurate imaging markers in dementia is highlighted by the potential for treatments targeting specific molecular abnormalities as well as the responsiveness to cholinesterase inhibitors and marked neuroleptic sensitivity of DLB. We review various brain imaging techniques that have been applied to investigate DLB, including the characteristic nigrostriatal degeneration in DLB using positron emission tomography (PET) and single-photon emission computed tomography (SPECT) tracers. Dopamine transporter loss has proven to reliably differentiate DLB from other dementias and has been incorporated into the revised clinical diagnostic criteria for DLB. To date, this remains the 'gold standard' for diagnostic imaging of DLB. Regional cerebral blood flow, 18 F-fluorodeoxygluclose-PET and SPECT have also identified marked deficits in the occipital regions with relative sparing of the medial temporal lobe when compared to Alzheimer's disease. In addition, structural, diffusion, and functional magnetic resonance imaging techniques have shown alterations in structure, white matter integrity, and functional activity in DLB. We argue that the multimodal identification of DLB-specific biomarkers has the potential to improve ante-mortem diagnosis and contribute to our

  12. Capgras syndrome in Dementia with Lewy Bodies

    PubMed Central

    Thaipisutikul, Papan; Lobach, Iryna; Zweig, Yael; Gurnani, Ashita; Galvin, James E.

    2014-01-01

    Background Capgras syndrome is characterized by the recurrent, transient belief that a person has been replaced by an identical imposter. We reviewed clinical characteristics of Dementia with Lewy Bodies (DLB) patients with Capgras syndrome compared to those without Capgras. Methods We identified 55 consecutive DLB patients (11 cases with Capgras syndrome (DLB-C) and 44 cases without evidence of Capgras (DLB). Semi-structured interviews with the patient and an informant, neurological exams, and neuropsychological testing were performed. Caregivers were assessed for caregiver burden and depression. Primary comparisons were made between DLB-C and DLB. Exploratory analyses using stepwise logistic regression and bootstrap analyses were performed to determine clinical features associated with Capgras. Results DLB-C patients experienced more visual hallucinations and self-reported anxiety, had higher scores on the Neuropsychiatric Inventory, and were less likely to be treated with cholinesterase inhibitors at time of initial evaluation. Extrapyramidal symptoms and depression were not associated with Capgras. Caregivers of DLB-C patients had higher caregiver burden. DLB-C was associated with self-reported anxiety (OR 10.9; 95% CI 2.6-47.6). In a bootstrap analysis, clinical findings that were predictors of Capgras included visual hallucinations (log(OR) 18.3; 95% CI 17.9-19.3) and anxiety (log(OR) 2.9; 95% CI (0.31-20.2). Conclusions Our study suggests that Capgras syndrome is common in DLB and usually occurs in the presence of anxiety and visual hallucinations, suggesting related etiopathogenesis. Early appreciation of Capgras syndrome may afford the opportunity to alleviate caregiver burden and improve patient and caregiver outcomes. PMID:23211760

  13. Lewis inverse design code (LINDES): Users manual

    NASA Technical Reports Server (NTRS)

    Sanz, Jose M.

    1987-01-01

    The method of complex characteristics and hodograph transformation for the design of shockless airfoils was introduced by Bauer, Garabedian, and Korn and has been extended by the author to design subcritical and supercritical cascades with high solidities and large inlet angles. This new capability was achieved by introducing a new conformal mapping of the hodograph domain onto an ellipse and expanding the solution in terms of Chebyshev polynomials. A new computer code, the NASA Lewis inverse design code, was developed based on this idea. This new design code is an efficient method for the design of airfoils in cascade. In particular, the design of subcritical cascades of airfoils is a very fast, robust, and versatile process. The inverse design code can be made to interact with a turbulent boundary layer calculation to obtain airfoils with no separated flows at the design condition. This report is intended to serve as a users manual for this design code. Material previously reported by the author is included here for completeness and quick access to the user. The manual contains a description of the method followed by a discussion of the design procedure and examples. The input parameters necessary to run the code are then described and their default values given. Output listings corresponding to six different blade shapes designed with the code are given, as well as the necessary input data to reproduce the computer runs. The examples have been chosen to show that a wide range of applications can be covered with the code, ranging from supercritical propeller sections to wind tunnel turning vanes that can operate with a large inlet flow angle range.

  14. Observations of wing-feather molt and summer feeding ecology of Steller's Eiders at Nelson Lagoon, Alaska

    USGS Publications Warehouse

    Petersen, Margaret R.

    1980-01-01

    The population size, moult chronology, food habits, and feeding behaviour of Steller's Eiders Polysticta stelleri were studied at Nelson Lagoon, Alaska from May to October 1977. Sub-adults were flightless from late July to late August and the adult males were flightless from late August to mid September. Adult females were rarely flightless at Nelson Lagoon but commonly flightless at Izembek Bay. Steller's Eiders ate primarily bivalve mollusca and amphipod crustacea, with Mytilus edulis and Anisogammarus pugettensis the most important foods. Eiders took amphipoda prior to the wing-feather moult, bivalves during the wing-feather moult, and both types of invertebrates after the wing-feather moult. Steller's Eiders fed primarily at the low tide by diving (flock-feeding) or head-dipping, both during the day and at night. There was no difference in feeding behaviour between ages or sexes. Eiders fed almost exclusively by diving after the wing-feather moult and apparently fed more as the season progressed.

  15. The development of hippocampal-dependent memory functions: Theoretical comments on Jabès and Nelson review (2015)

    PubMed Central

    2015-01-01

    Studies investigating the development of memory processes and their neural substrates have flourished over the last two decades. The review by Jabès and Nelson (2015) adds an important piece to our understanding of the maturation of different elements and circuits within the hippocampal system and their association with the progressive development of hippocampal-dependent memory processes in humans. In this accompanying commentary, we explore some additional connections between the nonhuman primate work and the human data, and take the opportunity to highlight some common and additional interpretations of the results. This commentary makes three points: (1) the recognition processes present in the first few days of life may be linked to the early maturation of the medial temporal cortical areas instead of, or in addition to, the early maturation of the subiculum; (2) recent findings on the differential protracted maturation of spatial relational memory processes in monkeys further support the notion proposed by Jabès and Nelson that this protracted development may reflect progressive maturation of the CA1 field of the hippocampus followed by further maturation of CA3/dentate gyrus; (3) finally, further considerations of the differential maturation of the longitudinal hippocampal axis and of the diencephalon are proposed as additional contributors to the refinement of episodic memory functions during development. PMID:26366027

  16. Pareidolias: complex visual illusions in dementia with Lewy bodies.

    PubMed

    Uchiyama, Makoto; Nishio, Yoshiyuki; Yokoi, Kayoko; Hirayama, Kazumi; Imamura, Toru; Shimomura, Tatsuo; Mori, Etsuro

    2012-08-01

    Patients rarely experience visual hallucinations while being observed by clinicians. Therefore, instruments to detect visual hallucinations directly from patients are needed. Pareidolias, which are complex visual illusions involving ambiguous forms that are perceived as meaningful objects, are analogous to visual hallucinations and have the potential to be a surrogate indicator of visual hallucinations. In this study, we explored the clinical utility of a newly developed instrument for evoking pareidolic illusions, the Pareidolia test, in patients with dementia with Lewy bodies-one of the most common causes of visual hallucinations in the elderly. Thirty-four patients with dementia with Lewy bodies, 34 patients with Alzheimer's disease and 26 healthy controls were given the Pareidolia test. Patients with dementia with Lewy bodies produced a much greater number of pareidolic illusions compared with those with Alzheimer's disease or controls. A receiver operating characteristic analysis demonstrated that the number of pareidolias differentiated dementia with Lewy bodies from Alzheimer's disease with a sensitivity of 100% and a specificity of 88%. Full-length figures and faces of people and animals accounted for >80% of the contents of pareidolias. Pareidolias were observed in patients with dementia with Lewy bodies who had visual hallucinations as well as those who did not have visual hallucinations, suggesting that pareidolias do not reflect visual hallucinations themselves but may reflect susceptibility to visual hallucinations. A sub-analysis of patients with dementia with Lewy bodies who were or were not treated with donepzil demonstrated that the numbers of pareidolias were correlated with visuoperceptual abilities in the former and with indices of hallucinations and delusional misidentifications in the latter. Arousal and attentional deficits mediated by abnormal cholinergic mechanisms and visuoperceptual dysfunctions are likely to contribute to the development

  17. Friedrich Heinrich Lewy (1885-1950) and his work.

    PubMed

    Holdorff, Bernd

    2002-03-01

    In 1912, Friedrich Heinrich Lewy first described the inclusion bodies named after him and seen in paralysis agitans (p.a.). Tretiakoff had found (1919) that the nucleus niger is most likely to be affected but in a subsequent large-scale series of post-mortem examinations (1923). Lewy was able to confirm this for a minority of cases only, with the exception of those that displayed postencephalitic Parkinsonism (and an unknown number of atypical Parkinson syndrome cases not identified until the 1960s). In a speculative paper (1932), he saw similarities between inclusion bodies in p.a. and viral diseases like lyssa and postulated a viral genesis of p.a. In a historical review of basal ganglia diseases (1942), he did not mention the putative significance of the inclusion bodies for the post-mortem diagnosis. It seems that their importance was seen only after Lewy's death, long after Tretiakoff's initial naming of the 'corps de Lewy'. Lewy, however, had already described their diffuse and cortical distribution (1923). An identification of diffuse Lewy body disease or dementia followed much later. Lewy's career in many diverse branches of neurology and internal medicine was strongly affected by World War I and the difficult situation faced by Jews in Germany. Shortly after the Neurological Institute was founded in Berlin in 1932 (as a clinic and research institute), he was forced, in 1933, to emigrate. His exile in England and the United States mirrors the fate of many German Jews and academics in the first half of the 20th century.

  18. Statement of Facts for 1975 City-Wide Mock Trial Competitions. Georgia Floyd, Individually and as Parent and Next Friend of Minor, Nelson Floyd v. Fix-It Home Remodeling, Inc. and Sam Baldwin.

    ERIC Educational Resources Information Center

    National Inst. for Citizen Education in the Law, Washington, DC.

    Prepared by the District of Columbia Street Law Project for its annual city-wide mock trial competition, this instructional handout provides material for a civil trial over a claim for damages. During an argument, a friend pushed Nelson Floyd against the railing of a porch. Falling onto the concrete below, Nelson was injured with a broken shin…

  19. Direct simulations of premixed turbulent flames with nonunity Lewis numbers

    NASA Technical Reports Server (NTRS)

    Rutland, C. J.; Trouve, A.

    1993-01-01

    A principal effect of turbulence on premixed flames in the flamelet regime is to wrinkle the flame fronts. For nonunity Lewis numbers, Le is not equal to 1, the local flame structure is altered in curved regions. This effect is examined using direct numerical simulations of 3D isotropic turbulence with constant density, single-step Arrhenius kinetics chemistry. Simulations of Lewis numbers 0.8, 1.0, and 1.2 are compared. At the local level, curvature effects dominated changes to the flame structure while strain effects were insignificant. A strong Lewis-number-dependent correlation was found between surface curvature and the local flame speed. The correlation was positive for Le less than 1 and negative for Le greater than 1. At the global level, strain-related effects were more significant than curvature effects. The turbulent flame speed changed significantly with Lewis number, increasing as Le decreased. This was found to be due to strain effects that have a nonzero mean over the flame surface, rather than to curvature effects that have a nearly zero mean. The mean product temperature was also found to vary with Lewis number, being higher for Le greater than 1 and lower for Le less than 1.

  20. Habitat Selection and Reproductive Success of Lewis's Woodpecker (Melanerpes lewis) at Its Northern Limit

    PubMed Central

    Zhu, Xiang; Srivastava, Diane S.; Martin, Kathy

    2012-01-01

    Lewis's Woodpecker (Melanerpes lewis) has experienced population declines in both Canada and the United States and in 2010 was assigned a national listing of threatened in Canada. We conducted a two-year study (2004–2005) of this species at its northern range limit, the South Okanagan Valley in British Columbia, Canada. Our main objective was to determine whether the habitat features that influenced nest-site selection also predicted nest success, or whether other factors (e.g. cavity dimensions, clutch initiation date or time of season) were more important. Nest tree decay class, density of suitable cavities and total basal area of large trees were the best predictors of nest-site selection, but these factors were unrelated to nesting success. Estimates of demographic parameters (mean ± SE) included daily nest survival rate (0.988±0.003, years combined), nest success (0.52±0.08), clutch size (5.00±0.14 eggs), female fledglings per successful nest (1.31±0.11), and annual productivity (0.68±0.12 female fledglings per nest per year). Although higher nest survival was associated with both early and late initiated clutches, early-initiated clutches allowed birds to gain the highest annual productivity as early clutches were larger. Nests in deep cavities with small entrances experienced lower predation risk especially during the peak period of nest predation. We concluded that nest-site selection can be predicted by a number of easily measured habitat variables, whereas nest success depended on complicated ecological interactions among nest predators, breeding behaviors, and cavity features. Thus, habitat-based conservation strategies should also consider ecological factors that may not be well predicted by habitat. PMID:23028525

  1. Effects of non-unity Lewis numbers in diffusion flames

    NASA Technical Reports Server (NTRS)

    Linan, A.; Orlandi, P.; Verzicco, R.; Higuera, F. J.

    1994-01-01

    The purpose of this work is to carry out direct numerical simulations of diffusion controlled combustion with non-unity Lewis numbers for the reactants and products, thus accounting for the differential diffusion effects of the temperature and concentration fields. We use a formulation based on combining the conservation equations in a way to eliminate the reaction terms similar to the method used by Burke and Schumann (1928) for unity Lewis numbers. We present calculations for an axisymmetric fuel jet and for a planar, time evolving mixing layer, leaving out the effects of thermal expansion and variations of the transport coefficients due to the heat release. Our results show that the front of the flame shifts toward the fuel or oxygen sides owing to the effect of the differential diffusion and that the location of maximum temperature may not coincide with the flame. The dependence of the distribution of the reaction products on their Lewis number has been investigated.

  2. Helicopter transmission testing at NASA Lewis Research Center

    NASA Technical Reports Server (NTRS)

    Lewicki, David G.; Coy, John J.

    1987-01-01

    The helicopter has evolved into a highly valuable air mobile vehicle for both military and civilian needs. The helicopter transmission requires advanced studies to develop a technology base for future rotorcraft advances. A joint helicopter transmission research program between the NASA Lewis Research Center and the U.S. Army Aviation Systems Command has existed since 1970. Program goals are to reduce weight and noise and to increase life and reliability. The current experimental activities at Lewis consist of full-scale helicopter transmission testing, a base effort in gearing technology, and a future effort in noise reduction technology. The experimental facilities at Lewis for helicopter transmission testing are described. A description of each of the rigs is presented along with some significant results and near-term plans.

  3. Utilization of NASA Lewis mobile terminals for the Hermes satellite

    NASA Technical Reports Server (NTRS)

    Edelman, E. A.; Fiala, J. L.; Rizzolla, L.

    1977-01-01

    The high power of the Hermes satellite enables two-way television and voice communication with small ground terminals. The Portable Earth Terminal (PET) and the Transportable Earth Terminal (TET) were developed and built by NASA-Lewis to provide communications capability to short-term users. The NASA-Lewis mobile terminals are described in terms of vehicles and onboard equipment, as well as operation aspects, including use in the field. The section on demonstrations divides the uses into categories of medicine, education, technology and government. Applications of special interest within each category are briefly described.

  4. Bibliography of Lewis Research Center technical contributions announced in 1976

    NASA Technical Reports Server (NTRS)

    1977-01-01

    Abstracts of Lewis authored publications and publications resulting from Lewis managed contracts which were announced in the 1976 issues of STAR (Scientific and Technical Aerospace Reports) and IAA (International Aerospace Abstracts) are presented. Research reports, journal articles, conference presentations, patents and patent applications, and these are included. The arrangement is by NASA subject category. Citations indicate report literature (identified by their N-numbers) and the journal and conference presentations (identified by their A-numbers). A grouping of indexes helps locate specific publications by author (including contractor authors), contractor organization, contract number, and report number.

  5. Space Chemical Propulsion Test Facilities at NASA Lewis Research Center

    NASA Technical Reports Server (NTRS)

    Urasek, Donald C.; Calfo, Frederick D.

    1993-01-01

    The NASA Lewis Research Center, located in Cleveland, Ohio, has a number of space chemical propulsion test facilities which constitute a significant national space testing resource. The purpose of this paper is to make more users aware of these test facilities and to encourage their use through cooperative agreements between the government, industry, and universities. Research which is of interest to the government is especially encouraged and often can be done in a cooperative manner that best uses the resources of all parties. An overview of the Lewis test facilities is presented.

  6. Summary of Research Report Lewis Incubator for Technology

    NASA Technical Reports Server (NTRS)

    Zeman, Wayne P.

    2000-01-01

    This report summarizes the work done to establish and operate the Lewis Incubator for Technology (LIFT) for the period July 1996 through September 2000. The Lewis Incubator helps the startup and growth of technology-based businesses with the potential to incorporate technology from the NASA Glenn Research Center. During the grant period, LIFT began operation, met or exceeded all key performance measures, and continues its operation through a new cooperative agreement with NASA Glenn and also through continued funding from the State of Ohio.

  7. Gear and Transmission Research at NASA Lewis Research Center

    NASA Technical Reports Server (NTRS)

    Townsend, Dennis P.

    1997-01-01

    This paper is a review of some of the research work of the NASA Lewis Research Center Mechanical Components Branch. It includes a brief review of the NASA Lewis Research Center and the Mechanical Components Branch. The research topics discussed are crack propagation of gear teeth, gear noise of spiral bevel and other gears, design optimization methods, methods we have investigated for transmission diagnostics, the analytical and experimental study of gear thermal conditions, the analytical and experimental study of split torque systems, the evaluation of several new advanced gear steels and transmission lubricants and the evaluation of various aircraft transmissions. The area of research needs for gearing and transmissions is also discussed.

  8. 77 FR 1667 - Nelson S. Galgoul, Av. Edison Passess 909, Rio De Janeiro, R.J., Brazil 20531-070, Respondent...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-01-11

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF COMMERCE Bureau of Industry and Security Nelson S. Galgoul, Av. Edison Passess 909, Rio De Janeiro, R.J., Brazil... a last known address of Av. Edison Passess 909, Rio De Janeiro, R.J., Brazil 20531-070, and...

  9. Does Humor Have an Effect on the Performance of College Freshmen in Improving Scores on the Nelson Denny Reading Post Test?

    ERIC Educational Resources Information Center

    Schiller, Maryann F.

    A study was conducted to investigate the effects of humor on the performance of college freshmen on the Nelson Denny Reading Post Test. The subjects, 36 college freshmen from two developmental reading improvement classes, were randomly assigned to experimental A or B or control sample groups. Students had previously taken forms F and C of the test…

  10. [Quantification of the Nelson de Moraes's indicator (curve of proportional mortality). Revista de Saúde Pública, 7:103-13, 1973].

    PubMed

    Guedes, José da Silva; Guedes, Marilda Lauretti da Silva

    2006-12-01

    Working with the Nelson de Moraes's indicator (curve of proportional mortality) it is introduced a criterion to quantify the curves, trying in this way a numeric value that, synthetizing the contribution of the different age groups to the mortality, indicates the level of health.

  11. Does Deafness Spell Disaster? An Analysis of the Written English Levels of Deaf Children in the Nelson Mandela Metropole, South Africa

    ERIC Educational Resources Information Center

    Weir, Carolyn; Aylif, Diana

    2014-01-01

    This article presents the findings of an empirical comparative study in the Nelson Mandela Metropole investigating the difference between the written English of deaf children and the written English of hearing children and makes recommendations on how to improve the writing of deaf children. The psycholinguistic approach was used for the…

  12. Improving health care through evaluation research: an interview with Katherine Nelson by Pamela J Wood and Lynne S Giddings.

    PubMed

    Nelson, Katherine

    2006-11-01

    Proposals for establishing or changing health care services are increasingly expected to include a framework for evaluating their delivery and effectiveness. Evaluation research in health care is therefore a rapidly developing area. It is crucial that nurses understand how to use this methodology effectively so they can make a case for the establishment, continuation or expansion of a health service and improve existing ones. This article describes aspects of evaluation research as interpreted by Katherine Nelson (RN, MA, PhD) in interview. It is the sixteenth article in a series based on interviews with nursing and midwifery researchers, and is primarily designed to offer the new researcher a first-hand account of the experience of using research methodologies. Kathy is a lecturer in the Graduate School of Nursing, Midwifery & Health at Victoria University of Wellington. She has undertaken several research projects evaluating different health care programmes.

  13. Measuring water accumulation rates using GRACE data in areas experiencing glacial isostatic adjustment: The Nelson River basin

    NASA Astrophysics Data System (ADS)

    Lambert, A.; Huang, J.; Kamp, G.; Henton, J.; Mazzotti, S.; James, T. S.; Courtier, N.; Barr, A. G.

    2013-12-01

    Recovery and Climate Experiment (GRACE) satellite-derived total water storage can be obscured by glacial isostatic adjustment. In order to solve this problem for the Nelson River drainage basin in Canada, a gravity rate map from 110 months (June 2002 to October 2011) of GRACE gravity data was corrected for glacial isostatic adjustment using an independent gravity rate map derived from updated GPS vertical velocities. The GPS-based map was converted to equivalent gravity rate using a transfer function developed from GPS and absolute-g data at colocated sites. The corrected GRACE gravity rate map revealed a major positive anomaly within the drainage basin, which was independently shown by hydrological data to be due to changes in water storage. The anomaly represents a cumulative increase at its center of about 340 mm of water, reflecting a progression from extreme drought to extremely wet conditions.

  14. A comparative analysis of simulated and observed landslide locations triggered by Hurricane Camille in Nelson County, Virginia

    USGS Publications Warehouse

    Morrissey, M.M.; Wieczorek, G.F.; Morgan, B.A.

    2008-01-01

    In 1969, Nelson County, Virginia received up to 71 cm of rain within 12 h starting at 7 p.m. on August 19. The total rainfall from the storm exceeded the 1000-year return period in the region. Several thousands of landslides were induced by rainfall associated with Hurricane Camille causing fatalities and destroying infrastructure. We apply a distributed transient response model for regional slope stability analysis to shallow landslides. Initiation points of over 3000 debris flows and effects of flooding from this storm are applied to the model. Geotechnical data used in the calculations are published data from samples of colluvium. Results from these calculations are compared with field observations such as landslide trigger location and timing of debris flows to assess how well the model predicts the spatial and temporal distribution. of landslide initiation locations. The model predicts many of the initiation locations in areas where debris flows are observed. Copyright ?? 2007 John Wiley & Sons, Ltd.

  15. Lewis Y Antigen as a Target for Breast Cancer Therapy

    DTIC Science & Technology

    1998-09-01

    that peptide mimotopes of adenocarcinomac associated carbohydrate forms that include Lewis Y may function4as a breast cancer vaccine , 3.) established the...the feasibility of peptide mimotopes and design requirements for their use as potential vaccine surrogates for carbohydrate antigens in future vaccine ...understanding mechanisms associated with the utility of peptide mimotopes for vaccine efficacy, priming with mimicking peptides might establish beneficial

  16. Q & A with Ed Tech Leaders: Interview with Brian Lewis

    ERIC Educational Resources Information Center

    Shaughnessy, Michael F.; Fulgham, Susan M.

    2013-01-01

    Brian Lewis, International Society for Technology in Education (ISTE) chief executive officer, is an education advocate and leader specializing in management and governance, policy, corporate communications, branding, and marketing. He provides leadership to ISTE's Washington, DC, and Eugene, Oregon, offices and directs organizational…

  17. False Recognition in Lewy-Body Disease and Frontotemporal Dementia

    ERIC Educational Resources Information Center

    de Boysson, C.; Belleville, S.; Phillips, N. A.; Johns, E. K.; Goupil, D.; Souchay, C.; Bouchard, R.; Chertkow, H.

    2011-01-01

    The primary goal of this study was to evaluate the false recognition phenomenon in persons with frontotemporal dementia (FTD) and those with Lewy-body disease (LBD). Patients with LBD (n=10) or FTD (n=15) and their corresponding controls (n=30) were subjected to the Deese-Roediger-McDermott (DRM) paradigm to induce false recognition. Patients were…

  18. Effects of Lewis Number on Temperatures of Spherical Diffusion Flames

    NASA Technical Reports Server (NTRS)

    Santa, K. J.; Sun, Z.; Chao, B. H.; Sunderland, P. B.; Axelbaum, R. I.; Urban, D. L.; Stocker, D. P.

    2007-01-01

    Spherical diffusion flames supported on a porous sphere were studied numerically and experimentally. Experiments were performed in 2.2 s and 5.2 s microgravity facilities. Numerical results were obtained from a Chemkin-based program. The program simulates flow from a porous sphere into a quiescent environment, yields both steady-state and transient results, and accounts for optically thick gas-phase radiation. The low flow velocities and long residence times in these diffusion flames lead to enhanced radiative and diffusive effects. Despite similar adiabatic flame temperatures, the measured and predicted temperatures varied by as much as 700 K. The temperature reduction correlates with flame size but characteristic flow times and, importantly, Lewis number also influence temperature. The numerical results show that the ambient gas Lewis number would have a strong effect on flame temperature if the flames were steady and nonradiating. For example, a 10% decrease in Lewis number would increase the steady-state flame temperature by 200 K. However, for these transient, radiating flames the effect of Lewis number is small. Transient predictions of flame sizes are larger than those observed in microgravity experiments. Close agreement could not be obtained without either increasing the model s thermal and mass diffusion properties by 30% or reducing mass flow rate by 25%.

  19. Lewis Latimer: African American Inventor, Poet and Activist.

    ERIC Educational Resources Information Center

    Judd, Michael

    1998-01-01

    Details a lesson plan that examines the life and career of Lewis Latimer. Latimer, the self-taught son of fugitive slaves, rose to a prominent position in Thomas Edison's Electric Company and pioneered many innovations in the early electric industry. Includes a biographical sketch of Latimer, photographs, and illustrations. (MJP)

  20. 165. Photocopy of Photograph (original in Roger Lewis' private collection). ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    165. Photocopy of Photograph (original in Roger Lewis' private collection). Photographer and date unknown. MILNER DAM, TWIN FALLS COUNTY, MILNER IDAHO; CRANES USED TO PLACE ROCK ON DAM; NOTE ELECTRIC RAILROAD CAR AT LEFT. - Milner Dam & Main Canal: Twin Falls Canal Company, On Snake River, 11 miles West of city of Burley, Idaho, Twin Falls, Twin Falls County, ID

  1. Sialyl Lewis x expression in cervical scrapes of premalignant lesions.

    PubMed

    Velázquez-Márquez, Noé; Santos-López, Gerardo; Jiménez-Aranda, Lucio; Reyes-Leyva, Julio; Vallejo-Ruiz, Verónica

    2012-12-01

    Sialylated oligosaccharides of glycoproteins and glycolipids have been implicated in tumour progression and metastases. Altered expression of glycosidic antigens has been reported in cervical cancer. In cervix premalignant lesions, an increased expression of sialic acid has been reported. In the present study we determined the expression profiles of the glycosidic antigens Tn, sialyl Tn (sTn), Lewis a (Lea), sialyl Lewis a (sLea), Lewis x (Lex) and sialyl Lewis x (sLex) in cervical scrapes with cytological diagnoses of normal, low-grade squamous intraepithelial lesions (LGSIL) and highgrade squamous intraepithelial lesions (HGSIL). Cervical scrapings were collected to detect tumour antigens expressions by flow cytometry using monoclonal antibodies. Cytometry analysis of Tn, sTn, Lea and Lex did not reveal differences at the expression level among groups. The number of positive cells to sLea antigen increased in the HGSIL group with respect to the normal group (p=0.0495). The number of positive cells to sLex antigen in the samples increased with respect to the grade of squamous intraepithelial lesion (SIL) (p less than 0.001, Mann-Whitney U test). The intensity of expression of this antigen increased in the HGSIL samples with respect to normal samples (p less than 0.0068). sLex antigen could be a candidate to be used as biomarker for the early diagnosis of cervical cancer.

  2. Bibliography of Lewis Research Center Technical Publications announced in 1991

    NASA Technical Reports Server (NTRS)

    1992-01-01

    This compilation of abstracts describes and indexes the technical reporting that resulted from the scientific engineering work performed and managed by the Lewis Research Center in 1991. All the publications were announced in the 1991 issues of STAR (Scientific and Technical Aerospace Reports) and/or IAA (International Aerospace Abstracts). Included are research reports, journal articles, conference presentations, patents and patent applications, and theses.

  3. Metabolic connectomics targeting brain pathology in dementia with Lewy bodies.

    PubMed

    Caminiti, Silvia P; Tettamanti, Marco; Sala, Arianna; Presotto, Luca; Iannaccone, Sandro; Cappa, Stefano F; Magnani, Giuseppe; Perani, Daniela

    2017-04-01

    Dementia with Lewy bodies is characterized by α-synuclein accumulation and degeneration of dopaminergic and cholinergic pathways. To gain an overview of brain systems affected by neurodegeneration, we characterized the [18F]FDG-PET metabolic connectivity in 42 dementia with Lewy bodies patients, as compared to 42 healthy controls, using sparse inverse covariance estimation method and graph theory. We performed whole-brain and anatomically driven analyses, targeting cholinergic and dopaminergic pathways, and the α-synuclein spreading. The first revealed substantial alterations in connectivity indexes, brain modularity, and hubs configuration. Namely, decreases in local metabolic connectivity within occipital cortex, thalamus, and cerebellum, and increases within frontal, temporal, parietal, and basal ganglia regions. There were also long-range disconnections among these brain regions, all supporting a disruption of the functional hierarchy characterizing the normal brain. The anatomically driven analysis revealed alterations within brain structures early affected by α-synuclein pathology, supporting Braak's early pathological staging in dementia with Lewy bodies. The dopaminergic striato-cortical pathway was severely affected, as well as the cholinergic networks, with an extensive decrease in connectivity in Ch1-Ch2, Ch5-Ch6 networks, and the lateral Ch4 capsular network significantly towards the occipital cortex. These altered patterns of metabolic connectivity unveil a new in vivo scenario for dementia with Lewy bodies underlying pathology in terms of changes in whole-brain metabolic connectivity, spreading of α-synuclein, and neurotransmission impairment.

  4. Mach 6 Integrated Systems Tests of Lewis' Hypersonic Tunnel Facility

    NASA Technical Reports Server (NTRS)

    1996-01-01

    A series of 15 integrated systems tests were conducted at the NASA Lewis Research Center's Hypersonic Tunnel Facility (HTF) with test conditions simulating flight up to Mach 6. Facility stagnation conditions up to 3050 R and 1050 psia were obtained with typical test times of 20 to 45 sec.

  5. Impact of Predatory Threat on Fear Extinction in Lewis Rats

    ERIC Educational Resources Information Center

    Goswami, Sonal; Cascardi, Michele; Rodriguez-Sierra, Olga E.; Duvarci, Sevil; Pare, Denis

    2010-01-01

    Humans with post-traumatic stress disorder (PTSD) are deficient at extinguishing conditioned fear responses. A study of identical twins concluded that this extinction deficit does not predate trauma but develops as a result of trauma. The present study tested whether the Lewis rat model of PTSD reproduces these features of the human syndrome.…

  6. Liquid droplet radiator program at the NASA Lewis Research Center

    NASA Technical Reports Server (NTRS)

    Presler, A. F.; Coles, C. E.; Diem-Kirsop, P. S.; White, K. A., III

    1985-01-01

    The NASA Lewis Research Center and the Air Force Rocket Propulsion Laboratory (AFRPL) are jointly engaged in a program for technical assessment of the Liquid Droplet Radiator (LDR) concept as an advanced high performance heat ejection component for future space missions. NASA Lewis has responsibility for the technology needed for the droplet generator, for working fluid qualification, and for investigating the physics of droplets in space; NASA Lewis is also conducting systems/mission analyses for potential LDR applications with candidate space power systems. For the droplet generator technology task, both micro-orifice fabrication techniques and droplet stream formation processes have been experimentally investigated. High quality micro-orifices (to 50 micron diameter) are routinely fabricated with automated equipment. Droplet formation studies have established operating boundaries for the generation of controlled and uniform droplet streams. A test rig is currently being installed for the experimental verification, under simulated space conditions, of droplet radiation heat transfer performance analyses and the determination of the effect radiative emissivity of multiple droplet streams. Initial testing has begun in the NASA Lewis Zero-Gravity Facility for investigating droplet stream behavior in microgravity conditions. This includes the effect of orifice wetting on jet dynamics and droplet formation. Results for both Brayton and Stirling power cycles have identified favorable mass and size comparisons of the LDR with conventional radiator concepts.

  7. Bibliography of Lewis Research Center technical publications announced in 1983

    NASA Technical Reports Server (NTRS)

    1984-01-01

    This compilation of abstracts describes and indexes over 800 technical publications that resulted from the scientific and engineering work performed and managed by the Lewis Research Center in 1983. Announced in the 1983 issues of STAR (Scientific and Technical Aerospace Reports) and/or IAA (International Aerospace Abstracts), the documents cited include research reports, journal articles, conference presentations, patents and patent applications, and theses.

  8. Telling Lewis Hine's Story: Russell Freedman's "Kids at Work."

    ERIC Educational Resources Information Center

    Zarnowski, Myra

    In "Kids at Work," Russell Freedman explores the world of child labor during the years 1908-1918 when Lewis Hine, "teacher-crusader," worked as an investigative photographer for the National Child Labor Committee (NCLC). Hine's writing and the photos he gathered from across the country revealed a "shocking reality that…

  9. Modified NASA-Lewis chemical equilibrium code for MHD applications

    NASA Technical Reports Server (NTRS)

    Sacks, R. A.; Geyer, H. K.; Grammel, S. J.; Doss, E. D.

    1979-01-01

    A substantially modified version of the NASA-Lewis Chemical Equilibrium Code was recently developed. The modifications were designed to extend the power and convenience of the Code as a tool for performing combustor analysis for MHD systems studies. The effect of the programming details is described from a user point of view.

  10. Bibliography of Lewis Research Center technical publications announced in 1980

    NASA Technical Reports Server (NTRS)

    1981-01-01

    This compilation of abstracts describes and indexes over 780 research reports, journal articles, conference presentations, patents and patent applications, and theses resulting from the scientific and engineering work performed and managed by the Lewis Research Center in 1980. All the publications were announced in Scientific and Technical Aerospace Reports and/or International Aerospace Abstracts.

  11. Cholinesterase Inhibitors for Lewy Body Disorders: A Meta-Analysis

    PubMed Central

    Yasue, Ichiro; Iwata, Nakao

    2016-01-01

    Background: We performed a meta-analysis of cholinesterase inhibitors for patients with Lewy body disorders, such as Parkinson’s disease, Parkinson’s disease dementia, and dementia with Lewy bodies. Methods: The meta-analysis included only randomized controlled trials of cholinesterase inhibitors for Lewy body disorders. Results: Seventeen studies (n = 1798) were assessed. Cholinesterase inhibitors significantly improved cognitive function (standardized mean difference [SMD] = −0.53], behavioral disturbances (SMD = −0.28), activities of daily living (SMD = −0.28), and global function (SMD = −0.52) compared with control treatments. Changes in motor function were not significantly different from control treatments. Furthermore, the cholinesterase inhibitor group had a higher all-cause discontinuation (risk ratio [RR] = 1.48, number needed to harm [NNH] = 14), discontinuation due to adverse events (RR = 1.59, NNH = 20), at least one adverse event (RR = 1.13, NNH = 11), nausea (RR = 2.50, NNH = 13), and tremor (RR = 2.30, NNH = 20). Conclusions: Cholinesterase inhibitors appear beneficial for the treatment of Lewy body disorders without detrimental effects on motor function. However, a careful monitoring of treatment compliance and side effects is required. PMID:26221005

  12. 174. Photocopy of Photograph (original in Roger Lewis' private collection). ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    174. Photocopy of Photograph (original in Roger Lewis' private collection). Photographer and date unknown. SNAKE RIVER BELOW MILNER DAM SITE, TWIN FALLS COUNTY, MILNER, IDAHO; RAPIDS JUST BELOW MILNER TOWNSITE. - Milner Dam & Main Canal: Twin Falls Canal Company, On Snake River, 11 miles West of city of Burley, Idaho, Twin Falls, Twin Falls County, ID

  13. Research and technology highlights of the Lewis Research Center

    NASA Technical Reports Server (NTRS)

    1984-01-01

    Highlights of research accomplishments of the Lewis Research Center for fiscal year 1984 are presented. The report is divided into four major sections covering aeronautics, space communications, space technology, and materials and structures. Six articles on energy are included in the space technology section.

  14. Bibliography of Lewis Research Center technical publications announced in 1982

    NASA Technical Reports Server (NTRS)

    1983-01-01

    The technical reporting that resulted from the scientific and engineering work performed and managed by the Lewis Research Center in 1982 is described. All the publications were announced in the 1982 issues of STAR (Scientific and Technical Aerospace Reports) and/or IAA (International Aerospace Abstracts). Included are research reports, journal articles, conference presentations, patents and patent applications, and theses.

  15. Beyond "Discovery": Lewis & Clark from an Indigenous Perspective.

    ERIC Educational Resources Information Center

    Littlebear, Richard

    2003-01-01

    Recontextualizes the history of the Lewis and Clark expedition from a Native American perspective. Argues that the success of the expedition hastened killing of American Indians and more firmly entrenched U.S. government policies toward indigenous peoples. Stresses that education, particularly at tribal colleges, is the key to success for…

  16. "Termanal" Science? The Work of Lewis Terman Revisited.

    ERIC Educational Resources Information Center

    Vialle, Wilma

    1994-01-01

    This article place's Lewis Terman's work in the context of his time and space, in response to criticism of biases against women and certain ethnic groups in his work. The paper concludes that, notwithstanding the unacceptability of his ideas on women and race, Terman's work provides an important foundation for the field of gifted education.…

  17. Californian Genius: Lewis Terman's Gifted Child in Regional Perspective

    ERIC Educational Resources Information Center

    Beauvais, Clémentine

    2016-01-01

    This article pays attention to the regional embeddedness of early research on giftedness, looking principally at the works of Lewis Terman and his peers, between the 1910s and 1930s. The rhetoric, ideology, and aesthetics of giftedness in those early works were, I argue, stamped by the context and imaginary of Progressive-Era California and shaped…

  18. Lewis Terman: Genetic Study of Genius--Elementary School Students

    ERIC Educational Resources Information Center

    Jolly, Jennifer L.

    2008-01-01

    Although the field of gifted education generally recognizes the foundational work of Lewis Terman, rarely does one stop to examine the details of his longitudinal study and their connection to present-day gifted education. This article reexamines the beginnings of Terman's longitudinal study with a focus on elementary-school-aged children.…

  19. Lewis M. Terman and the "World" of Test Publishing.

    ERIC Educational Resources Information Center

    Minton, Henry L.

    The association between Lewis M. Terman and the World Book Company is traced in order to gain insight about the role of test publishing in the testing movement. The test publisher assumes the position of an intermediary between the test developer and the educational administrator responsible for making decisions about test adoption. Terman began…

  20. Impact of predatory threat on fear extinction in Lewis rats.

    PubMed

    Goswami, Sonal; Cascardi, Michele; Rodríguez-Sierra, Olga E; Duvarci, Sevil; Paré, Denis

    2010-10-01

    Humans with post-traumatic stress disorder (PTSD) are deficient at extinguishing conditioned fear responses. A study of identical twins concluded that this extinction deficit does not predate trauma but develops as a result of trauma. The present study tested whether the Lewis rat model of PTSD reproduces these features of the human syndrome. Lewis rats were subjected to classical auditory fear conditioning before or after exposure to a predatory threat that mimics a type of traumatic stress that leads to PTSD in humans. Exploratory behavior on the elevated plus maze 1 wk after predatory threat exposure was used to distinguish resilient vs. PTSD-like rats. Properties of extinction varied depending on whether fear conditioning and extinction occurred before or after predatory threat. When fear conditioning was carried out after predatory threat, PTSD-like rats showed a marked extinction deficit compared with resilient rats. In contrast, no differences were seen between resilient and PTSD-like rats when fear conditioning and extinction occurred prior to predatory threat. These findings in Lewis rats closely match the results seen in humans with PTSD, thereby suggesting that studies comparing neuronal interactions in resilient vs. at-risk Lewis rats might shed light on the causes and pathophysiology of human PTSD.

  1. Who Needs Lewis Structures to Get VSEPR Geometries?

    ERIC Educational Resources Information Center

    Lindmark, Alan F.

    2010-01-01

    Teaching the VSEPR (valence shell electron-pair repulsion) model can be a tedious process. Traditionally, Lewis structures are drawn and the number of "electron clouds" (groups) around the central atom are counted and related to the standard VSEPR table of possible geometries. A simpler method to deduce the VSEPR structure without first drawing…

  2. 168. Photocopy of Photograph (original in Roger Lewis' private collection). ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    168. Photocopy of Photograph (original in Roger Lewis' private collection). Photographer and date unknown. MILNER DAM TUNNEL CONSTRUCTION, TWIN FALLS COUNTY, MILNER, IDAHO; WORKERS STANDING IN TUNNEL (ONE CAN BE SEEN AT FAR END OF TUNNEL). - Milner Dam & Main Canal: Twin Falls Canal Company, On Snake River, 11 miles West of city of Burley, Idaho, Twin Falls, Twin Falls County, ID

  3. Comparative assessment of the organization of the colors of the Vita Classical color pallet by digital images and visual analysis for dental bleaching

    NASA Astrophysics Data System (ADS)

    Oliveira-Júnior, O. B.; Cioffi, Mariana S.; Cesnik, R. M.; Florez, Fernando L. E.; Bagnato, Vanderlei S.; Corrêa-dos-Santos, Diego R.; Fornazari, Fabio P.

    2009-02-01

    New formularizations, techniques and devices have become the dental whitening most safe and with better results. Although this, the verification of the levels whitening is being continued for visual comparison, that is an empirical, subjective method, subject to errors and dependent of the individual interpretation. Normally the result of the whitening is express for the amplitude of displacement between the initial and the final color, being take like reference the tonalities of a scale of color commanded of darkest for more clearly. Although to be the most used scale , the ordinance of the Vita Classical ® - Vita, according to recommendations of the manufacturer, reveals inadequate for the evaluation of the whitening. From digital images and of algorithm OER (ordinance of the reference scale), especially developed for the ScanWhite ©, the ordinance of the tonalities of the scale Vita Classical® was made. For such, the values of the canals of color R, G, and B of medium part average of the crowns was adopted as reference for evaluation. The images had been taken with the camera Sony Cybershoot DSC F828. The results of the computational ordinance had been compared with the sequence proposal for the manufacturer and with the earned one for the visual evaluation, carried through by 10 volunteers, under standardized conditions of illumination. It statistics analyzes demonstrated significant differences between the ordinances.

  4. 76 FR 62835 - Notice of Inventory Completion: Fort Lewis College, Durango, CO

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-10-11

    ... National Park Service Notice of Inventory Completion: Fort Lewis College, Durango, CO AGENCY: National Park... Anthropology, Fort Lewis College, 1000 Rim Dr., Durango, CO 81301, telephone (970) 247-7500. SUPPLEMENTARY... funerary objects in the possession of Fort Lewis College, Durango, CO. The human remains and...

  5. Microgravity noncontact temperature requirements at NASA Lewis Research Center

    NASA Technical Reports Server (NTRS)

    Santoro, G.

    1989-01-01

    NASA Lewis Research Center is currently supporting 66 microgravity science and applications projects. The 66 projects are separated into 23 flight projects and 43 ground-based projects. The part of the NASA Lewis program dealing with flight experiments is divided into six areas: Combustion Science, Materials Science, Fluid Physics, Instrumentation/Equipment, Advanced Technology Development, and Space Station Multi-User Facility studies. The part of the NASA Lewis program dealing with ground-based experiments is coincidentally also divided into six areas: Electronic Materials, Combustion Science, Fluid Dynamics and Transport Phenomena, Metals and Alloys, Glasses and Ceramics, and Physics and Chemistry Experiments. Several purposes exist for ground-based experimenting. Preliminary information is necessary before a decision can be made for flight status, the short low gravity durations available in ground facilities are adequate for a particular study, or extensive ground-based research must be conducted to define and support the microgravity science endeavors contemplated for space. Not all of the 66 microgravity science and application projects at NASA Lewis have temperature requirements, but most do. Since space allocation does not permit a review of all the pertinent projects, a decision was made to restrict the coverage to the science flight projects, flight projects minus the advanced technology development, and multiuser facility efforts. Very little is lost by this decision as the types of temperature requirements for science flight projects can be considered representative of those for the ground-based projects. The noncontact temperature needs at NASA Lewis, as represented by the science flight projects are discussed by describing briefly the experiments themselves, by displaying an illustration of each experimental setup, and by specifying their temperature requisites.

  6. Impairment of script comprehension in Lewy body spectrum disorders.

    PubMed

    Gross, Rachel G; Camp, Emily; McMillan, Corey T; Dreyfuss, Michael; Gunawardena, Delani; Cook, Philip A; Morgan, Brianna; Siderowf, Andrew; Hurtig, Howard I; Stern, Matthew B; Grossman, Murray

    2013-06-01

    A disabling impairment of higher-order language function can be seen in patients with Lewy body spectrum disorders such as Parkinson's disease (PD), Parkinson's disease dementia (PDD), and dementia with Lewy bodies (DLB). We focus on script comprehension in patients with Lewy body spectrum disorders. While scripts unfold sequentially, constituent events are thought to contain an internal organization. Executive dysfunction in patients with Lewy body spectrum disorders may interfere with comprehension of this internal structure. We examined 42 patients (30 non-demented PD and 12 mildly demented PDD/DLB patients) and 12 healthy seniors. We presented 22 scripts (e.g., "going fishing"), each consisting of six events. Pilot data from young controls provided the basis for organizing associated events into clusters and arranging them hierarchically into scripts. We measured accuracy and latency to judge the order of adjacent events in the same cluster versus adjacent events in different clusters. PDD/DLB patients were less accurate in their ordering judgments than PD patients and controls. Healthy seniors and PD patients were significantly faster to judge correctly the order of highly associated within-cluster event pairs relative to less closely associated different-cluster event pairs, while PDD/DLB patients did not consistently distinguish between these event-pair types. This relative insensitivity to the clustered-hierarchical organization of events was related to executive impairment and to frontal atrophy as measured by volumetric MRI. These findings extend prior work on script processing to patients with Lewy body spectrum disorders and highlight the potential impact of frontal/executive dysfunction on the daily lives of affected patients.

  7. Lewis acid-Lewis acid heterobimetallic cooperative catalysis: mechanistic studies and application in enantioselective aza-Michael reaction.

    PubMed

    Yamagiwa, Noriyuki; Qin, Hongbo; Matsunaga, Shigeki; Shibasaki, Masakatsu

    2005-09-28

    The full details of a catalytic asymmetric aza-Michael reaction of methoxylamine promoted by rare earth-alkali metal heterobimetallic complexes are described, demonstrating the effectiveness of Lewis acid-Lewis acid cooperative catalysis. First, enones were used as substrates, and the 1,4-adducts were obtained in good yield (57-98%) and high ee (81-96%). Catalyst loading was successfully reduced to 0.3-3 mol % with enones. To broaden the substrate scope of the reaction to carboxylic acid derivatives, alpha,beta-unsaturated N-acylpyrroles were used as monodentate, carboxylic acid derivatives. With beta-alkyl-substituted N-acylpyrroles, the reaction proceeded smoothly and the products were obtained in high yield and good ee. Transformation of the 1,4-adducts from enones and alpha,beta-unsaturated N-acylpyrroles afforded corresponding chiral aziridines and beta-amino acids. Detailed mechanistic studies, including kinetics, NMR analysis, nonlinear effects, and rare earth metal effects, are also described. The Lewis acid-Lewis acid cooperative mechanism, including the substrate coordination mode, is discussed in detail.

  8. Tuning the Lewis acidity of boranes in frustrated Lewis pair chemistry: implications for the hydrogenation of electron-poor alkenes.

    PubMed

    Nicasio, Juan A; Steinberg, Sebastian; Inés, Blanca; Alcarazo, Manuel

    2013-08-12

    An analysis of the metal-free reduction of electron deficient olefins by frustrated Lewis pairs indicates that the rate-determining step might be either the heterolytic cleavage of H2 to form an -onium borohydride salt, or the subsequent transfer of the hydride moiety to the substrate following a Michael-type addition reaction. While the use of strong Lewis acids such as B(C6F5)3 facilitates the first of these processes, hydride transfer to the olefin should be contrarily favoured by the use of weak Lewis acids which, for this very same reason, might be unable to promote the prior H2 split. After systematic testing of several boranes of different Lewis acidity (assessed by using the Childs' method) and steric demand, an optimal situation that employs tris(2,4,6-trifluorophenyl)borane was reached. Mixtures of this borane with 1,4-diazabicyclo[2.2.2]octane (DABCO) exhibited excellent catalytic activity for the hydrogenation of alkylidene malonates. In fact, this transformation could be achieved under milder conditions than those we reported previously. Moreover, the reaction scope could be expanded to other electron deficient olefins containing esters, sulfones or nitro functionalities as electron-withdrawing substituents.

  9. Theoretical model for VITA-educed coherent structures in the wall region of a turbulent boundary layer

    NASA Technical Reports Server (NTRS)

    Landahl, Marten T.

    1988-01-01

    Experiments on wall-bounded shear flows (channel flows and boundary layers) have indicated that the turbulence in the region close to the wall exhibits a characteristic intermittently formed pattern of coherent structures. For a quantitative study of coherent structures it is necessary to make use of conditional sampling. One particularly successful sampling technique is the Variable Integration Time Averaging technique (VITA) first explored by Blackwelder and Kaplan (1976). In this, an event is assumed to occur when the short time variance exceeds a certain threshold multiple of the mean square signal. The analysis presented removes some assumptions in the earlier models in that the effects of pressure and viscosity are taken into account in an approximation based on the assumption that the near-wall structures are highly elongated in the streamwise direction. The appropriateness of this is suggested by the observations but is also self consistent with the results of the model which show that the streamwise dimension of the structure grows with time, so that the approximation should improve with the age of the structure.

  10. For an indeterministic ethics. The emptiness of the rule in dubio pro vita and life cessation decisions

    PubMed Central

    Pavlovic, Dragan; Lehmann, Christian; Wendt, Michael

    2009-01-01

    It is generally claimed that there exist exceptional circumstances when taking human life may be approved and when such actions may be justified on moral grounds. Precise guidelines in the medical field for making such decisions concerning patients who are terminally ill or have irreparable injuries incompatible with a bearable life, are difficult to establish. Recommendations that take the particular logical form of a rule, such as "in dubio pro vita", "when in doubt favour life") have been suggested and in some countries incorporated into legal texts (Germany). We claim here that such a rule is of no value since it is open-ended and always allows for doubt, and a decision to employ measures that would support human life could always be argued to be a valid choice. Preservation of this rule could be encouraged, but giving it the force of law may put physicians at risk, as they may be challenged for choosing to terminate life in otherwise ethically and medically uncontroversial circumstances. PMID:19442284

  11. Space chemical propulsion test facilities at NASA Lewis Research Center

    NASA Technical Reports Server (NTRS)

    Urasek, Donald C.; Calfo, Frederick D.

    1993-01-01

    The NASA Lewis Research Center, located in Cleveland, Ohio has a number of space chemical propulsion test facilities which constitute a significant national space testing resource. The purpose of this paper is to make more users aware of these test facilities and to encourage their use through cooperative agreements between the government, industry, and universities. Research which is of interest to the government is especiallly encouraged and often can be done in a cooperative manner that best uses the resources of all parties. This paper presents an overview of the Lewis test facilities. These facilities are clustered into three test areas: the Rocket Engine Test Facilities (RETF), the Rocket Laboratory (RL), and the Cryogenic Components Laboratory (CCL).

  12. Microfluidic studies of CO2 sequestration by frustrated Lewis pairs.

    PubMed

    Voicu, Dan; Abolhasani, Milad; Choueiri, Rachelle; Lestari, Gabriella; Seiler, Caroline; Menard, Gabriel; Greener, Jesse; Guenther, Axel; Stephan, Douglas W; Kumacheva, Eugenia

    2014-03-12

    Frustrated Lewis pairs (FLPs) comprising sterically hindered Lewis acids and bases offer the capability to reversibly capture CO2 under mild reaction conditions. The determination of equilibrium constants and thermodynamic properties of these reactions should enable assessment of the efficiency of a particular FLP system for CO2 sequestration and provide insights for design of new, efficient formulations of FLP catalysts for CO2 capture. We have developed a microfluidic approach to studies of FLP-CO2 reactions, which provides their thermodynamic characterization that is not accessible otherwise. The approach enables the determination of the equilibrium reaction constants at different temperatures, the enthalpy, the entropy, and the Gibbs energy of these reactions, as well as the enhancement factor. The microfluidic methodology has been validated by applying it to the well-characterized reaction of CO2 with a secondary amine. The microfluidic approach can be applied for fundamental thermodynamic studies of other gas-liquid reactions.

  13. Engines and innovation: Lewis Laboratory and American propulsion technology

    NASA Technical Reports Server (NTRS)

    Dawson, Virginia Parker

    1991-01-01

    This book is an institutional history of the NASA Lewis Research Center, located in Cleveland, Ohio, from 1940, when Congress authorized funding for a third laboratory for the National Advisory Committee for Aeronautics, through the 1980s. The history of the laboratory is discussed in relation to the development of American propulsion technology, with particular focus on the transition in the 1940s from the use of piston engines in airplanes to jet propulsion and that from air-breathing engines to rocket technology when the National Aeronautics and Space Administration was established in 1958. The personalities and research philosophies of the people who shaped the history of the laboratory are discussed, as is the relationship of Lewis Research Center to the Case Institute of Technology.

  14. Review of recent thermophotovoltaic (TPV) research at Lewis Research Center

    NASA Technical Reports Server (NTRS)

    Chubb, Donald L.; Good, Brian S.; Wilt, David M.; Lowe, Roland A.; Fatemi, Navid S.; Hoffman, Richard H.; Scheiman, David

    1996-01-01

    Thermophotovoltaic (TPV) research at NASA Lewis Research Center that began in the late 1980's is reviewed. This work has been concentrated on low bandgap indium gallium arsenide (InGaAs) PV cells and rare earth yttrium aluminum garnet (YAG) thin film selective emitters, as well as, TPV system studies. An emittance theory has been developed for the thin film emitters. Experimental spectral emittance results for erbium Er-YAG and holmium Ho-YAG show excellent emittance (greater than or equal to .7) within the emission bands. The .75 eV InGaAs PV cells fabricated at Lewis have excellent quantum efficiency. An efficiency of 13% has been measured for this cell coupled to an Er-YAG selective emitter and a short pass IR filter.

  15. Review of Recent Thermophotovoltaic (TPV) Research at Lewis Research Center

    NASA Technical Reports Server (NTRS)

    Chubb, Donald L.; Good, Brian S.; Wilt, David M.; Lowe, Roland A.; Fatemi, Navid S.; Hoffman, Richard H.; Scheiman, David

    1995-01-01

    Thermophotovoltaic (TPV) research at NASA Lewis Research Center that began in the late 1980's is reviewed. This work has been concentrated on low bandgap indium gallium arsenide (InGaAs) PV calls and rare earth - yttrium aluminum garnet (YAG) thin film selective emitters, as well as, TPV system studies. An emittance theory has been developed for the thin film emitters. Experimental spectral emittance results for erbium Er-YAG and holmium Ho-YAG show excellent emittance (greater than or equal to 0.7) within the emission bands. The 0.75 eV InGaAs PV cells fabricated at Lewis have excellent quantum efficiency. An efficiency of 130% has been measured for this cell coupled to an Er-YAG selective emitter and a short pass IR filter.

  16. Bibliography of Lewis Research Center technical publications announced in 1981

    NASA Technical Reports Server (NTRS)

    1982-01-01

    Technical reporting that resulted from the scientific and engineering work performed and managed by the Lewis Research Center in 1981 are indexed and abstracted. All the publications were announced in the 1981 issues of STAR (Scientific and Technical Aerospace Reports) and/or IAA (International Aerospace Abstracts). Included are research reports, journal articles, conference presentations, patent applications, and theses. A total of 384 technical publications is listed.

  17. Bibliography of Lewis Research Center technical publications announced in 1993

    NASA Technical Reports Server (NTRS)

    1994-01-01

    This compilation of abstracts describes and indexes the technical reporting that resulted from the scientific and engineering work performed and managed by the Lewis Research Center in 1993. All the publications were announced in the 1993 issues of STAR (Scientific and Technical Aerospace Reports) and/or IAA (International Aerospace Abstracts). Included are research reports, journal articles, conference presentations, patents and patent applications, and theses.

  18. Bibliography of Lewis Research Center technical publications announced in 1984

    NASA Technical Reports Server (NTRS)

    1985-01-01

    This compilation of abstracts describes and indexes the technical reporting that resulted from the scientific and engineering work performed and managed by the Lewis Research Center in 1984. All the publications were announced in the 1984 issues of STAR (Scientific and Technical Aerospace Reports) and/or IAA (International Aerospace Abstracts). Included are research reports, journal articles, conference presentations, patents and patent applications, and theses.

  19. Chemical Inventory Management at NASA Lewis Research Center

    NASA Technical Reports Server (NTRS)

    Kraft, Shirley S.; Homan, Joseph R.; Bajorek, Michael J.; Dominguez, Manuel B.; Smith, Vanessa L.

    1997-01-01

    The Chemical Management System (CMS) is a client/server application developed with Power Builder and Sybase for the Lewis Research Center (LeRC). Power Builder is a client-server application development tool, Sybase is a Relational Database Management System. The entire LeRC community can access the CMS from any desktop environment. The multiple functions and benefits of the CMS are addressed.

  20. Structure Of Flame Balls At Low Lewis-number (SOFBALL)

    NASA Technical Reports Server (NTRS)

    Ronney, Paul D.

    1995-01-01

    The work has encompassed several topics related to the experimental and theoretical study of combustion limits in premixed flames at microgravity. These topics include (1) flame structure and stability at low Lewis number (which is the basis for the SOFBALL space flight experiment), (2) flame propagation and extinction in cylindrical tubes, and (3) experimental simulation of combustion processes using autocatalytic chemical reactions. Progress on each of these topics is outlined.

  1. Bibliography of Lewis Research Center technical publications announced in 1987

    NASA Technical Reports Server (NTRS)

    1988-01-01

    This compilation of abstracts describes and indexes the technical reporting that resulted from the scientific and engineering work performed and managed by the Lewis Research Center in 1987. All the publications were announced in the 1987 issues of STAR (Scientific and Technical Aerospace Reports) and/or IAA (International Aerospace Abstracts). Included are research reports, journal articles, conference presentations, patents and patent applications, and theses.

  2. Bibliography of Lewis Research Center technical publications announced in 1990

    NASA Technical Reports Server (NTRS)

    1991-01-01

    This compilation of abstracts describes and indexes the technical reporting that resulted from the scientific and engineering work performed and managed by the Lewis Research Center in 1990. All the publications were announced in the 1990 issues of STAR (Scientific and Technical Aerospace Reports) and/or IAA (International Aerospace Abstracts). Included are research reports, journal articles, conference presentations, patents and patent applications, and theses.

  3. Bibliography of Lewis Research Center technical publications announced in 1989

    NASA Technical Reports Server (NTRS)

    1990-01-01

    This compilation of abstracts describes and indexes the technical reporting that resulted from the scientific and engineering work performed and managed by the Lewis Research Center in 1989. All the publications were announced in the 1989 issues of STAR (Scientific and Technical Aerospace Reports) and/or IAA (International Aerospace Abstracts). Included are research reports, journal articles, conference presentations, patents and patent applications, and theses.

  4. Ion Thruster Development at NASA Lewis Research Center

    NASA Technical Reports Server (NTRS)

    Sovey, James S.; Hamley, John A.; Patterson, Michael J.; Rawlin, Vincent K.; Sarver-Verhey, Timothy R.

    1992-01-01

    Recent ion propulsion technology efforts at NASA's Lewis Research Center including development of kW-class xenon ion thrusters, high power xenon and krypton ion thrusters, and power processors are reviewed. Thruster physical characteristics, performance data, life projections, and power processor component technology are summarized. The ion propulsion technology program is structured to address a broad set of mission applications from satellite stationkeeping and repositioning to primary propulsion using solar or nuclear power systems.

  5. Bibliography of Lewis Research Center technical publications announced in 1992

    NASA Technical Reports Server (NTRS)

    1993-01-01

    This compilation of abstracts describes and indexes the technical reporting that resulted from the scientific and engineering work performed and managed by the Lewis Research Center in 1992. All the publications were announced in the 1992 issues of STAR (Scientific and Technical Aerospace Reports) and/or IAA (International Aerospace Abstracts). Included are research reports, journal articles, conference presentations, patents and patent applications, and theses.

  6. Lewis Structures Technology, 1988. Volume 1: Structural Dynamics

    NASA Technical Reports Server (NTRS)

    1988-01-01

    The specific purpose of the symposium was to familiarize the engineering structures community with the depth and range of research performed by the Structures Division of the Lewis Research Center and its academic and industrial partners. Sessions covered vibration control, fracture mechanics, ceramic component reliability, parallel computing, nondestructive testing, dynamical systems, fatigue and damage, wind turbines, hot section technology, structural mechanics codes, computational methods for dynamics, structural optimization, and applications of structural dynamics.

  7. Teaching Astronomy at Lewis and Clark Community College

    NASA Astrophysics Data System (ADS)

    Cornell, David A.

    2006-12-01

    Lewis and Clark Community College (LCCC) is a two-year college with "Tech Prep" programs in automotive technology, child development, drafting, office technology, and health occupations. LCCC invited me to teach astronomy as a temporary faculty member during fall semester 2006. As professor emeritus in physics with 40 years' teaching experience, I happily accepted the invitation. This talk describes the experience, emphasizing the way it served as an outreach to the community.

  8. Bibliography of Lewis Research Center technical publications announced in 1977

    NASA Technical Reports Server (NTRS)

    1978-01-01

    This compilation of abstracts describes and indexes over 780 technical reports resulting from the scientific and engineering work performed and managed by the Lewis Research Center in 1977. All the publications were announced in the 1977 issues of STAR (Scientific and Technical Aerospace Reports) and/or IAA (International Aerospace Abstracts). Documents cited include research reports, journal articles, conference presentations, patents and patent applications, and theses.

  9. A Comparison of Lead Abatement Technologies at Lewis Research Center

    NASA Technical Reports Server (NTRS)

    Jeziorowski, Luz Y.; Calla, Joanne

    1997-01-01

    In 1995, Lewis participated in a pilot test of Lead Specifications. The Specifications were sponsored by the Center to Protect Worker's Rights (CPWR). Entitled "Model Specifications for the Protection of Worker's from Lead on Steel Structures", one aspect of this endeavor was to test and compare several lead abatement technologies. The project overview, objectives, team, and requirements as well as abatement methods and materials are outlined.

  10. Bibliography of Lewis Research Center technical publications announced in 1986

    NASA Technical Reports Server (NTRS)

    1987-01-01

    This compilation of abstracts describes and indexes the technical reporting that resulted from the scientific and engineering work performed and managed by the Lewis Research Center in 1986. All the publications were announced in the 1986 issues of Scientific and Technical Aerospace Reports (STAR) and/or International Aerospace Abstracts (IAA). Included are research reports, journal articles, conference presentations, patents and patent applications, and theses.

  11. Bibliography of Lewis Research Center technical publications announced in 1988

    NASA Technical Reports Server (NTRS)

    1989-01-01

    This bibliography contains abstracts of the technical reports that resulted from the scientific and engineering work performed and managed by the Lewis Research Center in 1988. Subject, author, and corporate source indexes are also included. All the publications were announced in the 1988 issues of STAR (Scientific and Technical Aerospace Reports) and/or IAA (International Aerospace Abstracts). Included are research reports, journal articles, conference presentations, patents and patent applications, and theses.

  12. Bibliography of Lewis Research Center Technical Publications announced in 1979

    NASA Technical Reports Server (NTRS)

    1980-01-01

    This compilation of over 1100 abstracts describes and indexes the technical reporting that resulted from the scientific and engineering work performed and managed by the Lewis Research Center in 1979. All the publications were announced in the 1979 issues of STAR (Scientific and Technical Aerospace Reports) and/or IAA (International Aerospace Abstracts). Research reports, journal articles, conference presentations, patents and patent applications, and theses are included. Subject, author, corporate source, contract number, and report number indexes are provided.

  13. Update to the NASA Lewis Ice Accretion Code LEWICE

    NASA Technical Reports Server (NTRS)

    Wright, William B.

    1994-01-01

    This report is intended as an update to NASA CR-185129 'User's Manual for the NASA Lewis Ice Accretion Prediction Code (LEWICE).' It describes modifications and improvements made to this code as well as changes to the input and output files, interactive input, and graphics output. The comparison of this code to experimental data is shown to have improved as a result of these modifications.

  14. Carbon-CArbon bond formation by Lewis superacid catalysis.

    PubMed

    Dunach, Elisabet

    2014-11-01

    Diverse intramolecular cyclizations involving the formation of CC bonds are described using catalytic methodologies based on Lewis superacids. Examples are presented on 1,6-diene cyclizations to gem-dimethylcyclohexane structures. Tandem cyclization of trienes are described to afford bicyclic structures in reactions involving rearrangements. Hydroarylation of olefins and of allenes is developed in catalytic FriedelCrafts-type coupling processes, which can give rise to tandem reactions. The olfactory evaluation of the series of prepared compounds is also presented.

  15. Bibliography of Lewis Research Center technical publications announced in 1985

    NASA Technical Reports Server (NTRS)

    1986-01-01

    This compilation of abstracts describes and indexes the technical reporting that resulted from the scientific and engineering work performed and managed by the Lewis Research Center in 1985. All the publications were announced in the 1985 issues of STAR (Scientific and Technical Aerospace Reports) and/or IAA (International Aerospace Abstracts). Included are research reports, journal articles, conference presentations, patents and patent applications, and theses.

  16. Living memories of Myrna Lewis: her personal and international dimensions.

    PubMed

    Resnick, Rosa Perla

    2009-01-01

    Dr. Myrna Lewis was an outstanding social worker, researcher, author and lecturer in the field of Aging, who was definitely recognized as an international expert. Above all her professional achievements the quality of her reach and warm personality will remain as a lively memory for her colleagues and friends. She will be remembered as an authentic source of inspiration to all who knew her and to future generations.

  17. True Grit: In Tracking down the Real Story of a Legendary Hero of the Old West, Vaunda Micheaux Nelson also Nabbed the Coretta Scott King Award

    ERIC Educational Resources Information Center

    Fleishhacker, Joy

    2010-01-01

    When Vaunda Micheaux Nelson donned a black Stetson to become the biographer of Deputy U.S. Marshal Bass Reeves, she had no idea that her square-shooting book about an unsung African-American hero of the Old West would win over a posse of fans and earn her the prestigious 2010 Coretta Scott King (CSK) Author Award. "Bad News for Outlaws"…

  18. Lewis Wolpert discusses development and depression. Interview by Joanne Clough.

    PubMed

    Wolpert, Lewis

    2004-06-01

    Lewis Wolpert is Professor of Biology as Applied to Medicine in the Department of Anatomy and Developmental Biology at University College, London, UK. His research interests focus on the mechanisms that are involved in embryonic development. Lewis originally trained as a civil engineer in South Africa but in 1955 made the move to research in cellular biology at King's College, London. He was made a Fellow of the Royal Society in 1980 and awarded the CBE in 1990. Lewis was also made a Fellow of the Royal Society of Literature in 1999 and has presented science on both radio and TV for several years. He was awarded The Royal Society Michael Faraday Prize in 2000 for his contribution to the public understanding of science, most notably through his Chairmanship of the Committee for the Public Understanding of Science (COPUS; 1993-1998). He is the author of numerous books, including Malignant Sadness: The Anatomy of Depression, Principles of Development, The Unnatural Nature of Science and The Triumph of the Embryo. He also writes a regular column for The Independent.

  19. Lewis' Educational and Research Collaborative Intership Program Grant Closeout Report

    NASA Technical Reports Server (NTRS)

    2003-01-01

    The Lewis' Educational and Research Collaborative Internship Program (LERCIP) is a collaborative undertaking by the Office of Educational Programs at NASA Glenn Research Center at Lewis Field (formerly NASA Lewis Research Center) and the Ohio Aerospace Institute. This program provides 10-week internships and 10 or 12-week fellowships for undergraduate/graduate students and secondary school teachers. Approximately 130 interns are selected to participate in this program each year and begin arriving the second week in May. The internships provide students with introductory professional experiences to complement their academic programs. The interns are given assignments on research and development projects under the personal guidance of NASA professional staff members. Each intern is assigned a NASA mentor who facilitates a research assignment. In addition to the research assignment, the summer program includes a strong educational component that enhances the professional stature of the participants. The educational activities include a research symposium and a variety of workshops, lectures and short courses. An important aspect of the program is that it includes students with diverse social, cultural and economic backgrounds.

  20. LEWY BODY DEMENTIA: CAREGIVER BURDEN AND UNMET NEEDS

    PubMed Central

    Galvin, James E.; Duda, John E.; Kaufer, Daniel I.; Lippa, Carol F.; Taylor, Angela; Zarit, Steven H.

    2010-01-01

    Lewy body dementia (LBD) is a common cause of dementia but to date, little is known about caregiver burden. The Lewy Body Dementia Association (www.LBDA.org) conducted a web-based survey of 962 caregivers (mean age 56y; 88% women). The most common initial symptoms were cognitive (48%), motor (39%), or both (13%). Caregivers expressed concerns about fear of future (77%), feeling stressed (54%), loss of social life (52%) and uncertainty about what to do next (50%). Caregivers reported moderate to severe burden; 80% felt the people around them did not understand their burden and 54% reported feelings of isolation with spousal caregivers reporting more burden than non-spousal caregivers. Only 29% hired in-home assistance while less than 40% used respite or adult day care, geriatric case managers or attended a support group meeting. Lack of service utilization occurred despite two-thirds of caregivers reporting medical crises requiring emergency services, psychiatric care or law enforcement. Caregivers reported preferences for web-based information, directories of LBD expert providers, information on LBD research and location of local support groups. These findings highlight significant unmet needs for LBD caregivers and provide targets for intervention to reduce caregiver burden. Community resources such as the Lewy Body Dementia Association may serve this end, while also providing practical information and support for caregivers. PMID:20505434

  1. Planar chiral organoborane Lewis acids derived from naphthylferrocene.

    PubMed

    Chen, Jiawei; Venkatasubbaiah, Krishnan; Pakkirisamy, Thilagar; Doshi, Ami; Yusupov, Andrej; Patel, Yesha; Lalancette, Roger A; Jäkle, Frieder

    2010-08-02

    Enantiomerically pure metalated 2-(1-naphthyl)ferrocene (NpFc) derivatives NpFcM (M=SnMe(3), HgCl) were prepared and characterized by multinuclear NMR and UV/Vis spectroscopy, cyclic voltammetry, and elemental analysis. Optical rotation measurements were performed and the absolute configuration of the new planar chiral ferrocene species was confirmed by single-crystal X-ray diffraction analysis. The mercuriated species NpFcHgCl proved suitable as a reagent for the preparation of the chiral organoborane Lewis acid NpFcBCl(2), which can in turn be converted to other ferrocenylboranes by replacement of Cl with nucleophiles. The highly Lewis acidic perfluoroarylborane derivatives NpFcB(C(6)F(5))Cl and NpFcB(C(6)F(5))(2) were successfully prepared by treatment with CuC(6)F(5). The structures were studied by single-crystal X-ray diffraction and variable-temperature (19)F NMR spectroscopy, which suggested that pi stacking of a C(6)F(5) group on boron with the adjacent naphthyl group is energetically favorable. UV/Vis absorption spectroscopy and cyclic voltammetry measurements were performed to examine the electronic properties of these novel redox-active chiral Lewis acids.

  2. International conference on "Photosynthesis Research for Sustainability-2016" : In honor of Nathan Nelson and Turhan Nejat Veziroğlu.

    PubMed

    Tsygankov, Anatoly A; Allakhverdiev, Suleyman I; Tomo, Tatsuya; Govindjee

    2017-02-01

    During June 19-26, 2016, an international conference ( http://photosynthesis2016.cellreg.org/ ) on "Photosynthesis Research for Sustainability-2016" was held in honor of Nathan Nelson and Turhan Nejat Veziroğlu at the Institute of Basic Biological Problems, Russian Academy of Sciences, formerly Institute of Photosynthesis, Academy of Sciences of the USSR, Pushchino, Russia. Further, this conference celebrated the 50th anniversary of the Institute. We provide here a brief introduction and key contributions of the two honored scientists, and then information on the conference, on the speakers, and the program. A special feature of this conference was the awards given to several young investigators, who are recognized in this Report. Several photographs are included to show the excellent ambience at this conference. We invite the readers to the next conference on "Photosynthesis and Hydrogen Energy Research for Sustainability-2017", which will honor A.S. Raghavendra (of University of Hyderabad), William Cramer (of Purdue University) and Govindjee (of University of Illinois at Urbana-Champaign); it will be held during the Fall of 2017 (from October 30 to November 4), at the University of Hyderabad, Hyderabad, India. See < https://prs.science >.

  3. The complete mitochondrial genome of the gall-forming fly, Fergusonina taylori Nelson and Yeates (Diptera: Fergusoninidae).

    PubMed

    Nelson, Leigh A; Cameron, Stephen L; Yeates, David K

    2011-10-01

    The monogeneric family Fergusoninidae consists of gall-forming flies that, together with Fergusobia (Tylenchida: Neotylenchidae) nematodes, form the only known mutualistic association between insects and nematodes. In this study, the entire 16,000 bp mitochondrial genome of Fergusonina taylori Nelson and Yeates was sequenced. The circular genome contains one encoding region including 27 genes and one non-coding A+T-rich region. The arrangement of the protein-coding, ribosomal RNA (rRNA) and transfer RNA (tRNA) genes was the same as that found in the ancestral insect. Nucleotide composition is highly A+T biased. All of the protein initiation codons are ATN, except for nad1 which begins with TTT. All 22 tRNA anticodons of F. taylori match those observed in Drosophila yakuba, and all form the typical cloverleaf structure except for tRNA-Ser((AGN)) which lacks a dihydrouridine (DHU) arm. Secondary structural features of the rRNA genes of Fergusonina are similar to those proposed for other insects, with minor modifications. The mitochondrial genome of Fergusonina presented here may prove valuable for resolving the sister group to the Fergusoninidae, and expands the available mtDNA data sources for acalyptrates overall.

  4. Geology, hydrology, and water quality of the glacial drift aquifer in the vicinity of the Nelson landfill near Yorkville, Illinois

    USGS Publications Warehouse

    Kay, Robert T.

    2006-01-01

    The geologic and hydrologic characteristics of the sand-and-gravel deposits that compose the glacial drift aquifer in the vicinity of the Nelson Landfill site in Yor-kville, Illinois indicate that the aquifer could be devel-oped as a source of public water supply. The geology of these deposits within the Newark Bedrock Valley is com-plex, however, and a detailed investigation of their water bearing and transmitting properties will be required to successfully locate high-capacity wells. Volatile organic compounds, pesticides, and cyanide were not detected in ground water during this investiga-tion. Metals and nitrogen compounds were not detected at concentrations above their Maximum Contaminant Level. Iron, manganese, and aluminum were detected at concentrations above their Secondary Maximum Con-taminant Level and various constituents were detected at concentrations above background levels downgradi-ent of the landfill. Nitrate and ammonia, presumably derived from agricultural practices, also were detected in samples from locations hydraulically upgradient of the landfill. Oxidation-reduction conditions in the aquifer become more reducing with depth. This change is reflected by a change in the type of nitrogen compound detected and the concentration of dissolved oxygen and iron in the glacial drift aquifer. Concentrations of some of the major ions and metals may be affected by disso-lution of carbonate minerals in the aquifer and perhaps road salts.

  5. Mouse fibroblast L929 cells are less permissive to infection by Nelson Bay orthoreovirus compared to other mammalian cell lines.

    PubMed

    Mok, Lawrence; Wynne, James W; Grimley, Samantha; Shiell, Brian; Green, Diane; Monaghan, Paul; Pallister, Jackie; Bacic, Antony; Michalski, Wojtek P

    2015-07-01

    In recent years, bats have been identified as a natural reservoir for a diverse range of viruses. Nelson Bay orthoreovirus (NBV) was first isolated from the heart blood of a fruit bat (Pteropus poliocephalus) in 1968. While the pathogenesis of NBV remains unknown, other related members of this group have caused acute respiratory disease in humans. Thus the potential for NBV to impact human health appears plausible. Here, to increase our knowledge of NBV, we examined the replication and infectivity of NBV using different mammalian cell lines derived from bat, human, mouse and monkey. All cell lines supported the replication of NBV; however, L929 cells showed a greater than 2 log reduction in virus titre compared with the other cell lines. Furthermore, NBV did not induce major cytopathic effects in the L929 cells, as was observed in other cell lines. Interestingly, the related Pteropine orthoreoviruses, Pulau virus (PulV) and Melaka virus (MelV) were able to replicate to high titres in L929 cells but infection resulted in reduced cytopathic effect. Our study demonstrates a unique virus-host interaction between NBV and L929 cells, where cells effectively control viral infection/replication and limit the formation of syncytia. By elucidating the molecular mechanisms that control this unique relationship, important insights will be made into the biology of this fusogenic virus.

  6. Occurrence of odorant polyfunctional thiols in the Super Alpha Tomahawk hop cultivar. Comparison with the thiol-rich Nelson Sauvin bitter variety.

    PubMed

    Gros, Jacques; Nizet, Sabrina; Collin, Sonia

    2011-08-24

    Tomahawk hop (Humulus lupulus) is a recently developed Super Alpha cultivar (14-18% α-acids w/w), already widely used by brewers to impart bitterness and a citrus-like aroma to beer. By comparison with two bitter varieties (Nelson Sauvin and Nugget) and two aromatic ones (Cascade and Saaz), the Tomahawk cultivar showed a very particular terpenoid profile, rich in both α- and β-selinenes (>600 mg/kg IST equiv in total), methyl geranate (>40 mg/kg IST equiv), and geraniol (>200 mg/kg). Tomahawk also proved to contain a wide variety of odorant polyfunctional thiols. The major β-sulfanyl acetate, 3-sulfanyl-2-ethylpropyl acetate, newly identified here, was found at similar levels in the famous Sauvignon-like Nelson Sauvin and Tomahawk varieties (15-44 μg/kg IST equiv). On the other hand, lower levels of total β-sulfanyl alcohols were measured in Tomahawk, although 3-sulfanylhexan-1-ol was found at a similar level and the 3-sulfanyl-4-methylpentan-1-ol previously claimed to be specific to the Nelson Sauvin variety was also evidenced in the Super Alpha cultivar (9-13 μg/kg IST equiv). As revealed by boiling and fermentation, Tomahawk hop also contains very interesting bound polyfunctional thiols that should be investigated for better use by brewers.

  7. Gilbert Newton Lewis: his influence on physical-organic chemists at Berkeley

    SciTech Connect

    Calvin, M.

    1982-03-01

    A review is presented of the historical contributions of Gilbert N. Lewis to science and a discussion of the influence of Lewis on the research of the members of the physical-organic staff at Berkeley, including Melvin Calvin, during the twenties, thirties and forties. Some specific examples are discussed. Also, the effect of Lewis, his science and administrative concepts in the creation of excellence in a department of chemistry are reviewed.

  8. Identification and characteristics of new volatile thiols derived from the hop (Humulus luplus L.) cultivar Nelson Sauvin (dagger).

    PubMed

    Takoi, Kiyoshi; Degueil, Marie; Shinkaruk, Svitlana; Thibon, Cécile; Maeda, Katsuaki; Ito, Kazutoshi; Bennetau, Bernard; Dubourdieu, Denis; Tominaga, Takatoshi

    2009-03-25

    Nelson Sauvin (NS) is a unique hop cultivar that was bred and grown in New Zealand. This hop gives a specific flavor (exotic fruit-like, white wine-like) to finished beers. However, the key compounds of this flavor have not yet been identified. We have attempted to identify the specific flavor compounds derived from NS. We focused on certain volatile thiols that are well-known to contribute to wine flavors, especially Sauvignon Blanc. The product made from NS (NS product) lost its specific flavor by contact with copper. Copper is well-known as an absorber of thiols in the field of wine flavor investigations. Therefore, it might point to the existence of thiols. We analyzed the NS product by GC-FPD, GC-olfactometry and GC-MS, and identified two new volatile thiols, 3-sulfanyl-4-methylpentan-1-ol (3S4MP), and 3-sulfanyl-4-methylpentyl acetate (3S4MPA). These compounds have a grapefruit-like and/or rhubarb-like odor, similar to that of Sauvignon Blanc. We quantified these compounds in the NS products and determined their thresholds. As a result, 3S4MP contained about 2-fold of its threshold in beers, and 3S4MPA was included below its threshold. However, it was confirmed that 3S4MP enhanced the flavors of 3S4MPA by synergy. Therefore, we concluded that both of the new volatile thiols would contribute to the specific odor of beers produced with NS.

  9. The limits and robustness of reinforcement learning in Lewis signalling games

    NASA Astrophysics Data System (ADS)

    Catteeuw, David; Manderick, Bernard

    2014-04-01

    Lewis signalling games are a standard model to study the emergence of language. We introduce win-stay/lose-inaction, a random process that only updates behaviour on success and never deviates from what was once successful, prove that it always ends up in a state of optimal communication in all Lewis signalling games, and predict the number of interactions it needs to do so: N3 interactions for Lewis signalling games with N equiprobable types. We show three reinforcement learning algorithms (Roth-Erev learning, Q-learning, and Learning Automata) that can imitate win-stay/lose-inaction and can even cope with errors in Lewis signalling games.

  10. The Lewis heat pipe code with application to SP-100 GES heat pipes

    NASA Technical Reports Server (NTRS)

    Baker, Karl W.; Tower, Leonard K.

    1988-01-01

    The NASA Lewis Research Center has a thermal management program supporting SP-100 goals, which includes heat pipe radiator development. As a part of the program Lewis has elected to prepare an in-house heat pipe code tailored to the needs of its SP-100 staff to supplement codes from other sources. The latter, designed to meet the needs of the originating organizations, were deemed not entirely appropriate for use at Lewis. However, a review of their features proved most beneficial in the design of the Lewis code.

  11. LEWY BODY DEMENTIA: THE CAREGIVER EXPERIENCE OF CLINICAL CARE

    PubMed Central

    Galvin, James E.; Duda, John E.; Kaufer, Daniel I.; Lippa, Carol F.; Taylor, Angela; Zarit, Steven H.

    2010-01-01

    BACKGROUND Lewy body dementia (LBD) is the second most common cause of dementia, however, little is known about how the clinical diagnosis of LBD is obtained in the community or the caregiver experience while seeking the diagnosis. METHODS The Lewy Body Dementia Association (www.LBDA.org) conducted a web-based survey of 962 caregivers over a 6-month period. RESULTS The mean age of respondents was 55.9y; 88% were female and 64% had daily contact with patients. The mean age of LBD patients was 75.4y; 62% were male and 46% lived with a caregiver. The most common presentation of symptoms as reported by LBD caregivers was cognitive (48%), motor (39%) or both (13%). The first diagnoses given to the patients were Parkinson disease or other movement disorder (39%), Alzheimer disease or other cognitive disorder (36%), or mental illness (24%). Fifty percent of patients saw >3 doctors for more than 10 visits over the course of 1 year before an LBD diagnosis was established. Neurologists diagnosed most cases (62%), while primary care-providers diagnosed only 6% of cases. No differences were found between the presentation of disease and the number of physicians, number of office visits, length of time to establish diagnosis, or type of doctor who finally made an LBD diagnosis. Caregivers viewed physicians as knowledgeable about disease manifestations and treatment options, but not about disease course/prognosis and available community resources and referrals. CONCLUSIONS These data highlight a need for increasing physician awareness and knowledge of LBD, which will facilitate accurate diagnosis and treatment. Community resources such as the Lewy Body Dementia Association may serve this end, while also providing practical information and support for caregivers. PMID:20434939

  12. NASA Lewis advanced IPV nickel-hydrogen technology

    NASA Technical Reports Server (NTRS)

    Smithrick, John J.; Britton, Doris L.

    1993-01-01

    Individual pressure vessel (IPV) nickel-hydrogen technology was advanced at NASA Lewis and under Lewis contracts. Some of the advancements are as follows: to use 26 percent potassium hydroxide electrolyte to improve cycle life and performance, to modify the state of the art cell design to eliminate identified failure modes and further improve cycle life, and to develop a lightweight nickel electrode to reduce battery mass, hence reduce launch and/or increase satellite payload. A breakthrough in the LEO cycle life of individual pressure vessel nickel-hydrogen battery cells was reported. The cycle life of boiler plate cells containing 26 percent KOH electrolyte was about 40,000 accelerated LEO cycles at 80 percent DOD compared to 3,500 cycles for cells containing 31 percent KOH. Results of the boiler plate cell tests have been validated at NWSC, Crane, Indiana. Forty-eight ampere-hour flight cells containing 26 and 31 percent KOH have undergone real time LEO cycle life testing at an 80 percent DOD, 10 C. The three cells containing 26 percent KOH failed on the average at cycle 19,500. The three cells containing 31 percent KOH failed on the average at cycle 6,400. Validation testing of NASA Lewis 125 Ah advanced design IPV nickel-hydrogen flight cells is also being conducted at NWSC, Crane, Indiana under a NASA Lewis contract. This consists of characterization, storage, and cycle life testing. There was no capacity degradation after 52 days of storage with the cells in the discharged state, on open circuit, 0 C, and a hydrogen pressure of 14.5 psia. The catalyzed wall wick cells have been cycled for over 22,694 cycles with no cell failures in the continuing test. All three of the non-catalyzed wall wick cells failed (cycles 9,588; 13,900; and 20,575). Cycle life test results of the Fibrex nickel electrode has demonstrated the feasibility of an improved nickel electrode giving a higher specific energy nickel-hydrogen cell. A nickel-hydrogen boiler plate cell using an 80

  13. Lewis Structures Technology, 1988. Volume 2: Structural Mechanics

    NASA Technical Reports Server (NTRS)

    1988-01-01

    Lewis Structures Div. performs and disseminates results of research conducted in support of aerospace engine structures. These results have a wide range of applicability to practitioners of structural engineering mechanics beyond the aerospace arena. The engineering community was familiarized with the depth and range of research performed by the division and its academic and industrial partners. Sessions covered vibration control, fracture mechanics, ceramic component reliability, parallel computing, nondestructive evaluation, constitutive models and experimental capabilities, dynamic systems, fatigue and damage, wind turbines, hot section technology (HOST), aeroelasticity, structural mechanics codes, computational methods for dynamics, structural optimization, and applications of structural dynamics, and structural mechanics computer codes.

  14. Telecommuting (Work-At-Home) at NASA Lewis Research Center

    NASA Technical Reports Server (NTRS)

    Srinidhi, Saragur M.

    1994-01-01

    This report presents a study in evaluating the viability of providing a work-at-home (telecommuting) program for Lewis Research Center's corporate employees using Integrated Services Digital Network (ISDN). Case studies have been presented for a range of applications from casual data access to interactive access. The network performance of telemedia applications were studied against future requirements for such level of remote connectivity. Many of the popular ISDN devices were characterized for network and service functionality. A set of recommendations to develop a telecommuting policy have been proposed.

  15. Violence and mental illness: what Lewis Carroll had to say.

    PubMed

    Torrey, E Fuller; Miller, Judy

    2014-12-01

    In 1873 Skeffington Lutwidge, a Lunacy Commission inspector of asylums in England, was killed by an asylum patient. Lutwidge was the uncle and close friend of Charles Lutwidge Dodgson, also known as Lewis Carroll. One year later, Carroll began writing The Hunting of the Snark, a poem whose meaning has mystified Carroll enthusiasts. In fact, the poem is a description of the Lunacy Commission inspection team and reflects Carroll's personal understanding of, and reaction to, the killing of his uncle by an individual with a severe mental illness. Carroll's close relationship with his uncle also explains the prominence of psychotic thinking in Carroll's work, including the Mad Hatter's tea party.

  16. NASA Lewis and Ohio Company Hit Hole in One

    NASA Technical Reports Server (NTRS)

    1998-01-01

    Ben Hogan Company's Golf Ball Division, which is based in Elyria, Ohio, had developed concepts and prototypes for new golf balls but was unable to determine exact performance characteristics. Specifically, the company's R&D department wanted to measure the spin rates of experimental golf balls. After the Golf Ball Division requested assistance, researchers and technicians from the NASA Lewis Research Center went to Elyria and conducted several days worth of tests. Ben Hogan is using the test results to improve the spin characteristics of a new ball it plans to introduce to the market.

  17. Hypersonic engine seal development at NASA Lewis Research Center

    NASA Technical Reports Server (NTRS)

    Steinetz, Bruce M.

    1994-01-01

    NASA Lewis Research Center is developing advanced seal concepts and sealing technology for advanced combined cycle ramjet/scramjet engines being designed for the National Aerospace Plane (NASP). Technologies are being developed for both the dynamic seals that seal the sliding interfaces between articulating engine panels and sidewalls, and for the static seals that seal the heat exchanger to back-up structure interfaces. This viewgraph presentation provides an overview of the candidate engine seal concepts, seal material assessments, and unique test facilities used to assess the leakage and thermal performance of the seal concepts.

  18. Influence of Light Conditions and Light Sources on Clinical Measurement of Natural Teeth Color using VITA Easyshade Advance 4,0® Spectrophotometer. Pilot Study.

    PubMed Central

    Posavec, Ivona; Prpić, Vladimir

    2016-01-01

    Objectives The purpose of this study was to evaluate and compare lightness (L), chroma (C) and hue (h), green-red (a) and blue-yellow (b) character of the color of maxillary right central incisors in different light conditions and light sources. Materials and methods Two examiners who were well trained in digital color evaluation participated in the research. Intraclass correlation coefficients (ICCs) were used to analyze intra- and interobserver reliability. The LCh and L*a*b* values were determined at 08.15 and at 10.00 in the morning under three different light conditions. Tooth color was assessed in 10 subjects using intraoral spectrophotometer VITA Easyshade Advance 4.0® set at the central region of the vestibular surface of the measured tooth. Results Intra- and interobserver ICC values were high for both examiners and ranged from 0.57 to 0.99. Statistically significant differences in LCh and L*a*b* values measured in different time of the day and certain light condition were not found (p>0.05). Statistically significant differences in LCh and L*a*b* values measured under three different light conditions were not found, too (p>0.05). Conclusions VITA Easyshade Advance 4.0® is reliable enough for daily clinical work in order to assess tooth color during the fabrication of esthtic appliances because it is not dependent on light conditions and light sources. PMID:28275281

  19. In Vivo Evaluations of Inter-Observer Reliability Using VITA Easyshade® Advance 4.0 Dental Shade-Matching Device

    PubMed Central

    KNEZOVIĆ, Dubravka; ZLATARIĆ, Davor; Illeš, Iva Ž.; Alajbeg, Maja; Žagar

    2016-01-01

    Objectives The aim of this study was to evaluate the inter-observer reliability of dental shade-matching device using an in vivo model. Materials and methods Four observers who were well trained in color assessment and handling of the dental shade-matching device determined teeth color and CIE-Lab values on maxillary right central incisors in 10 patients with completely healthy and intact dentitions. VITA Easyshade® Advance 4.0 shade-matching device was utilized to measure the central region of the labial surface of all investigated teeth, twice by each observer. The inter-observer reliability of the measurements was observed and deviations between Lab and ∆E values between the observers were calculated. Intraclass correlation coefficients (ICCs) were used to analyze inter-observer reliability. Results One-way ANOVA showed no statistically significant differences in color measurement of four observers in all the measured values (p>0.05). Delta E values ranged from 3.018 to 5.234. Although some small differences existed, statistically significant differences between the observers were not found (p>0.05). Inter-observer ICCs were very high for all observers (from 0.651 to 0.992). Conclusion Inter-examiner reliability of measurements using VITA Easyshade® Advance 4.0 shade-matching device was acceptable. Apart from the digital equipment, a well trained observer seems to be crucial in order to achieve correct dental color measurement. PMID:27688424

  20. Carbohydrate antigen sialyl Lewis a--its pathophysiological significance and induction mechanism in cancer progression.

    PubMed

    Kannagi, Reiji

    2007-01-01

    Carbohydrate antigen sialyl Lewis a (CA19-9) is the most frequently applied serum tumor marker for diagnosis of cancers in the digestive organs. Recent progress disclosed the presence of a normal counterpart of the determinant, namely disialyl Lewis a, which is predominantly expressed in non-malignant epithelial cells of the digestive organs, while sialyl Lewis a is preferentially expressed in cancers. The disialyl Lewis a determinant carries one extra sialic residue attached through a 2 --> 6 linkage to the GlcNAc moiety compared to cancer-associated sialyl Lewis a, which carries only one 2 --> 3 linked sialic acid residue (monosialyl Lewis a). Disialyl Lewis a in normal epithelial cells serves as a ligand for immunosuppressive receptors such as sialic acid binding immunoglobulin (Ig)-like lectins (siglec-7) and -9 expressed on resident monocytes/macrophages and maintains immunological homeostasis of mucosal membranes in digestive organs. Epigenetic silencing of a gene for a 2 --> 6 sialyl-transferase in the early stages of carcinogenesis results in an impairment of 2 --> 6 sialylation, leading to incomplete synthesis and accumulation of sialyl Lewis a, which lacks the 2 --> 6 linked sialic acid residue, in cancer cells. Simultaneous determination of serum levels of sialyl- and disialyl Lewis a, and calculation of the monosialyl/disialyl Lewis a ratio provide information useful for excluding a false-positive serum diagnosis, and also for averting the undesired influence of the Lewis blood group of patients on serum antigen levels. During the course of cancer progression in locally advanced cancers, tumor hypoxia induces transcription of several glycogenes involved in sialyl Lewis a synthesis. Expression of the determinant, consequently, is further accelerated in more malignant hypoxia-resistant cancer cell clones, which become predominant clones in advanced stage cancers and frequently develop hematogenous metastasis. Sialyl Lewis a, as well as its positional

  1. Lewis base activation of Lewis acids: catalytic, enantioselective addition of glycolate-derived silyl ketene acetals to aldehydes.

    PubMed

    Denmark, Scott E; Chung, Won-Jin

    2008-06-20

    A catalytic system involving silicon tetrachloride and a chiral, Lewis basic bisphosphoramide catalyst is effective for the addition of glycolate-derived silyl ketene acetals to aldehydes. It was found that the sense of diastereoselectivity could be modulated by changing the size of the substituents on the silyl ketene acetals. In general, the trimethylsilyl ketene acetals derived from methyl glycolates with a large protecting group on the alpha-oxygen provide enantiomerically enriched alpha,beta-dihydroxy esters with high syn-diastereoselectivity, whereas the tert-butyldimethylsilyl ketene acetals derived from bulky esters of alpha-methoxyacetic acid provide enantiomerically enriched alpha,beta-dihydroxy esters with high anti-diastereoselecitvity.

  2. Applied imaging at the NASA Lewis Research Center

    NASA Astrophysics Data System (ADS)

    Slater, Howard A.; Owens, Jay C.

    1993-01-01

    NASA Lewis Research Center in Cleveland, Ohio has just completed the celebration of its 50th anniversary. `During the past 50 years, Lewis helped win World War II, made jet aircraft safer and more efficient, helped Americans land on the Moon ... and engaged in the type of fundamental research that benefits all of us in our daily lives.' As part of the center's long history, the Photographic and Printing Branch has continued to develop and meet the center's research imaging requirements. As imaging systems continue to advance and researchers more clearly understand the power of imaging, investigators are relying more and more on imaging systems to meet program objectives. Today, the Photographic and Printing Branch supports a research community of over 5,000 including advocacy for NASA Headquarters and other government agencies. Complete classified and unclassified imaging services include high- speed image acquisition, technical film and video documentaries, still imaging, and conventional and unconventional photofinishing operations. These are the foundation of the branch's modern support function. This paper provides an overview of the varied applied imaging programs managed by the Photographic and Printing Branch. Emphasis is placed on recent imaging projects including icing research, space experiments, and an on-line image archive.

  3. Metal-free pincer ligand chemistry polycationic phosphonium Lewis acids.

    PubMed

    Szkop, Kevin M; Stephan, Douglas W

    2017-03-07

    Oxidation of 2,6-bis(diphenylphosphine)methyl pyridine with MeO3SCF3, yields the dication [2,6-(CH2PMePh2)2C5H3N][CF3SO3]22, while subsequent treatment with two equivalents of [K(THF)n][B(C6F5)4] (n = 1.3-1.5) afforded [2,6-(CH2PMePh2)2C5H3N][B(C6F5)4]23. Analogous treatment using XeF2 afforded 2,6-(CH2PF2Ph2)2C5H3N 4, while subsequent fluoride abstractions afford the corresponding [BF4], [CF3SO3] and [B(C6F5)4] salts, 5-7, respectively. Compound 4 reacts with an excess of MeO3SCF3 to give [2,6-(CH2PF2Ph2)2C5H3N(CH3)][CF3SO3] 8 while subsequent reaction with [Et3Si·2C7H8][B(C6F5)4] gave the related tricationic species, 9. The Lewis acidity of these di- and triphosphonium cations 3, 7 and 9 was examined and their utility as Lewis acid catalysts was assessed in the dimerization of 1,1-diphenylethylene, the hydrodefluorination of 1-fluoroadamantane, and the dehydrocoupling of phenol and silane.

  4. Dementia with Lewy bodies: a comprehensive review for nurses.

    PubMed

    Ajon Gealogo, Gretchel

    2013-12-01

    Much of the current nursing literature on dementia focuses on Alzheimer disease (AD), the dementia subtype most commonly diagnosed in the older adults. There is a paucity of nursing literature on dementia with Lewy bodies (DLB), the second most common subtype of dementia, which is closely associated with Parkinson disease with dementia (PDD), considered the third most common dementia subtype. Both are aging-related disorders attributed to Lewy bodies, abnormal protein aggregates or "clumps" found to cause cumulative neurodegeneration over time. DLB is defined as dementia onset that is preceded by Parkinsonian symptoms for 1 year or less, whereas in PDD, 2 or more years of Parkinsonian symptoms precede dementia onset. Although basic science knowledge of DLB has increased exponentially, the lack of nursing research on DLB indicates that this knowledge excludes the nursing perspective and its implications for nursing practice. The purpose of this article is to provide nurses with a comprehensive overview of DLB as it compares with PDD and Alzheimer disease and to propose key nursing interventions for clinical practice.

  5. Transmission diagnostic research at NASA Lewis Research Center

    NASA Technical Reports Server (NTRS)

    Zakrajsek, J. J.; Townsend, D. P.; Lewicki, D. G.; Decker, H. J.; Handschuh, R. F.

    1995-01-01

    The NASA Lewis Research Center and the U.S. Army Research Laboratory are involved in a joint research program to advance the technology of aerospace transmissions. Within the last six years, a transmission diagnostics research team was formed to address current and future technology barriers in transmission diagnostics. The diagnostics team conducted a survey to determine critical needs of the diagnostics community. Survey results indicated that experimental verification of gear and bearing fault detection methods and damage magnitude assessment were considered the two most critical research areas of a highly reliable health and usage monitoring system. A plan was implemented by the diagnostics team to address these key research areas, by in-house research and university grants. A variety of transmission fault detection methods were applied to experimentally obtained fatigue data. Failure modes of the fatigue tests include a variety of gear pitting failures, tooth wear, tooth fracture, and bearing spalling failures. Accomplishments to date include verification of several specific gear diagnostic methods, verification of a new pattern recognition method to determine failure, and development of a new method to model gear tooth damage. This paper presents the results of these accomplishments in transmission diagnostics research at NASA Lewis Research Center.

  6. Lewis acid assisted methyl/chlorine exchange in silylated hydrazinochlorophosphanes.

    PubMed

    Westenkirchner, Andrea; Villinger, Alexander; Karaghiosoff, Konstantin; Wustrack, Ronald; Michalik, Dirk; Schulz, Axel

    2011-03-21

    Differently substituted hydrazinophosphanes of the type (Me(3)Si)(2)N-N(SiMe(3))-PR(1)R(2) (R(1) = Cl with R(2) = Me, C(6)F(5) and R(1) = Me, R(2) = C(6)H(5)) have been studied in the reaction with Lewis acids such as ECl(3) (E = Al, Ga). For (Me(3)Si)(2)N-N(SiMe(3))-P(Cl)(Me) and (Me(3)Si)(2)N-N(SiMe(3))-P(Me)(C(6)H(5)), only adduct formation was found while a chlorine/methyl exchange reaction was observed for (Me(3)Si)(2)N-N(SiMe(3))-P(Cl)R (R = C(6)H(5) and C(6)F(5)) leading to the formation of (Me(2)ClSi)(Me(3)Si)N-N(SiMe(3))-P(Me)R, which crystallize as ECl(3) adducts. The free hydrazinophosphanes can be obtained by removal of the Lewis acid with the help of a strong base such as 4-(dimethylamino)pyridine (DMAP).

  7. Transmission diagnostic research at NASA Lewis Research Center

    NASA Astrophysics Data System (ADS)

    Zakrajsek, J. J.; Townsend, D. P.; Lewicki, D. G.; Decker, H. J.; Handschuh, R. F.

    1995-05-01

    The NASA Lewis Research Center and the U.S. Army Research Laboratory are involved in a joint research program to advance the technology of aerospace transmissions. Within the last six years, a transmission diagnostics research team was formed to address current and future technology barriers in transmission diagnostics. The diagnostics team conducted a survey to determine critical needs of the diagnostics community. Survey results indicated that experimental verification of gear and bearing fault detection methods and damage magnitude assessment were considered the two most critical research areas of a highly reliable health and usage monitoring system. A plan was implemented by the diagnostics team to address these key research areas, by in-house research and university grants. A variety of transmission fault detection methods were applied to experimentally obtained fatigue data. Failure modes of the fatigue tests include a variety of gear pitting failures, tooth wear, tooth fracture, and bearing spalling failures. Accomplishments to date include verification of several specific gear diagnostic methods, verification of a new pattern recognition method to determine failure, and development of a new method to model gear tooth damage. This paper presents the results of these accomplishments in transmission diagnostics research at NASA Lewis Research Center.

  8. [Curriculum vitae aortae].

    PubMed

    Solberg, S

    1998-12-10

    The Greek word aorta means lifter. The vessel was so termed because Aristotle, who first described it, assumed that the heart was lifted by/hanging in aorta. Leonardo da Vinci described the detailed anatomy of aorta. During the 17th century our present understanding of the aorta and the circulation of blood took form due to the descriptions given by William Harvey. The first known operation for abdominal aortic aneurysm was performed in London in 1817 by Sir Astley Cooper who ligated the infrarenal aorta above the aneurysm. Puncture with needles and application of electricity were later tried in order to induce thromboses in the aneurysm. In 1948 Albert Einstein was operated with wrapping of his abdominal aneurysm with cellophane. In 1955 he suffered rupture and died after having refused operation. In 1951 the first successful operation for abdominal aortic aneurysm was performed in Paris by Charles Dubost. With slight modifications, the same operative technique is used today.

  9. [Nelson Rockefeller and the activities of the American International Association for Economic and Social Development: the debate concerning mission and imperialism in Brazil, 1946-1961].

    PubMed

    Silva, Claiton Marcio da

    2013-10-01

    The article analyzes the bibliography on Nelson Rockefeller and the activities of the American International Association for Economic and Social Development in Brazil. It describes optimistic interpretations of Rockefeller's and the association's work, as well as the nationalist stream of thought, which characterized him as one of the chief representatives of U.S. imperialism, both as a political representative in the 1960s and as the mind behind endeavors of interest to the private sector. It is shown that at the individual and agency levels alike, these initiatives involved direct ties to the local elites, who influenced the reshaping and operationalization of technical cooperation projects.

  10. p-hacking by post hoc selection with multiple opportunities: Detectability by skewness test?: Comment on Simonsohn, Nelson, and Simmons (2014).

    PubMed

    Ulrich, Rolf; Miller, Jeff

    2015-12-01

    Simonsohn, Nelson, and Simmons (2014) have suggested a novel test to detect p-hacking in research, that is, when researchers report excessive rates of "significant effects" that are truly false positives. Although this test is very useful for identifying true effects in some cases, it fails to identify false positives in several situations when researchers conduct multiple statistical tests (e.g., reporting the most significant result). In these cases, p-curves are right-skewed, thereby mimicking the existence of real effects even if no effect is actually present.

  11. The Triplet State: An Example of G. N. Lewis' Research Style.

    ERIC Educational Resources Information Center

    Kasha, Michael

    1984-01-01

    Examines background of ideas against which Lewis's last researches were done, reflecting on his conduct of scientific research. Also analyzes Lewis's unique habit of writing research previews and indicates, through his research memoranda to the author, his intensity of research interest and activity during the last years of his life. (JN)

  12. Enthalpy Costs of Making and Breaking Bonds: A Game of Generating Molecules with Proper Lewis Structures

    ERIC Educational Resources Information Center

    Bell, Peter T.; Adkins, Alyssa D.; Gamble, Rex J.; Schultz, Linda D.

    2009-01-01

    "Enthalpy Costs" is a simple card game created to assist students in developing proper Lewis structure drawing skills. Score keeping is accomplished by tracking the enthalpy changes associated with bond-making and bond-breaking processes during formation of molecules represented by proper Lewis structures. Playing the game requires the student to…

  13. LewiSpace: An Exploratory Study with a Machine Learning Model in an Educational Game

    ERIC Educational Resources Information Center

    Ghali, Ramla; Ouellet, Sébastien; Frasson, Claude

    2016-01-01

    The use of educational games as a tool for providing learners with a playful and educational aspect is widespread. In this paper, we present an educational game that we developed to teach a chemistry lesson, namely drawing a Lewis diagram. Our game is a 3D environment known as LewiSpace and aims at balancing between playful and educational…

  14. Oral Interpretation of C.S. Lewis'"Narnia Tales": A Refracting of "Pictures."

    ERIC Educational Resources Information Center

    Keefe, Carolyn

    "The Chronicles of Narnia" are a series of seven fairy tales written by C.S. Lewis that have become popular with both children and adults. Lewis points to five aspects of the fairy tale form that made the form suitable for expressing the images he saw. The aspects are: (1) no love interest; (2) no close psychology; (3) severe restraints…

  15. C.S. Lewis as a Forensic Figure in the Religious Agora.

    ERIC Educational Resources Information Center

    Keefe, Carolyn

    This paper considers the British thinker C.S. Lewis as a "forensic figure," defining "forensic" in the sense of public discussion and debate. The paper relates that, long before Lewis emerged as a public persuader, he learned to hold his own in private exchanges with William T. Kirkpatrick, his tutor from 1914-1917, and in…

  16. The First Confirmed Case of Down Syndrome with Dementia with Lewy Bodies

    ERIC Educational Resources Information Center

    Prasher, V. P.; Airuehia, E.; Carey, M.

    2010-01-01

    Dementia with Lewy bodies (DLB) is the second commonest cause of dementia in the general population. Several researches have established an association between Down syndrome (DS) and Alzheimer's disease. Very few studies have however showed such an association between dementia with Lewy bodies and Down syndrome. The occurrence of DLB in persons…

  17. Adele Parot: Beacon of the Dioclesian Lewis School of Gymnastic Expression in the American West.

    ERIC Educational Resources Information Center

    Barney, Robert Knight

    In the late 1800's, Dioclesian Lewis developed and introduced into the schools his new concept of physical education. Dr. Lewis thought in terms of preventing illness and maintaining bodily strength and health through physical fitness. His "new gymnastics" were based on programs of exercise movements. Employing light equipment suitable…

  18. Sentence Processing in Lewy Body Spectrum Disorder: The Role of Working Memory

    ERIC Educational Resources Information Center

    Gross, Rachel G.; McMillan, Corey T.; Chandrasekaran, Keerthi; Dreyfuss, Michael; Ash, Sharon; Avants, Brian; Cook, Philip; Moore, Peachie; Libon, David J.; Siderowf, Andrew; Grossman, Murray

    2012-01-01

    Prior work has related sentence processing to executive deficits in non-demented patients with Parkinson's disease (PD). We extended this investigation to patients with dementia with Lewy bodies (DLB) and PD dementia (PDD) by examining grammatical and working memory components of sentence processing in the full range of patients with Lewy body…

  19. 75 FR 42460 - Minor Boundary Revision at Lewis and Clark National Historical Park

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-07-21

    ... National Park Service Minor Boundary Revision at Lewis and Clark National Historical Park AGENCY: National Park Service, Interior. ACTION: Announcement of boundary revision. SUMMARY: Notice is hereby given that, pursuant to 16 U.S.C. 460l- (9)(c)(1), the boundary of Lewis and Clark National Historical Park is...

  20. An Integrated Perspective of Humanism and Supernaturalism for Education: C. S. Lewis's Version of Education

    ERIC Educational Resources Information Center

    Lee, Seung Chun

    2013-01-01

    This paper explores some theoretical reflections on the connection between C. S. Lewis's thoughts on the purpose and process of education and his understanding of supernatural human nature which has been relatively little explored. An introduction about Lewis's career as a college teacher blends into the background of this paper. It is followed by…

  1. 32 CFR Appendix C to Part 552 - Authorized Activities for Fort Lewis Maneuver Area Access

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 32 National Defense 3 2014-07-01 2014-07-01 false Authorized Activities for Fort Lewis Maneuver Area Access C Appendix C to Part 552 National Defense Department of Defense (Continued) DEPARTMENT OF.... 552, App. C Appendix C to Part 552—Authorized Activities for Fort Lewis Maneuver Area Access...

  2. 32 CFR Appendix C to Part 552 - Authorized Activities for Fort Lewis Maneuver Area Access

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 32 National Defense 3 2012-07-01 2009-07-01 true Authorized Activities for Fort Lewis Maneuver Area Access C Appendix C to Part 552 National Defense Department of Defense (Continued) DEPARTMENT OF.... 552, App. C Appendix C to Part 552—Authorized Activities for Fort Lewis Maneuver Area Access...

  3. On the Trail of Lewis and Clark: A Journey up the Missouri River.

    ERIC Educational Resources Information Center

    Lourie, Peter

    In 1804, Lewis and Clark and a band of adventurers called the Corps of Discovery embarked on one of the great expeditions in history, the exploration of the newly purchased Louisiana Territory. Much of their time was spent on the Missouri River. Two hundred years later, four friends follow Lewis and Clark's path up the Missouri. Their journey…

  4. Food insecurity among students living with HIV: Strengthening safety nets at the Nelson Mandela Metropolitan University, South Africa.

    PubMed

    Steenkamp, L; Goosen, A; Venter, D; Beeforth, M

    2016-12-01

    The HIV prevalence in South Africa among students at higher education institutions (HEIs) in 2008 was reported to be 3.4%, with the highest HIV prevalence found in the Eastern Cape Province. Students at these facilities are also increasingly affected by socio-economic constraints that may impact on food security. Little is known about the impact of food insecurity on HIV-infected students in HEIs in South Africa. The purpose of this paper is to describe food insecurity and the nutritional status among HIV-infected students on the Nelson Mandela Metropolitan University campuses in South Africa, as well as current initiatives to strengthen the safety nets for food-insecure students. This descriptive, cross-sectional survey was conducted among a convenience sample of known HIV-infected, registered students (n = 63), older than 18 years of age and managed as part of the Campus Health Service antiretroviral therapy (ART) programme. Ethical approval for the study was obtained from the Research Ethics Committee (NMMU) and participants were included in the sample after providing written, informed consent. Findings indicate that food insecurity was common with more than 60% of the sample reporting food insecurity at the household level during the previous month. Of the sample, 51% were classified as being either overweight or obese. Although food insecurity did not contribute to weight loss in our sample, food-insecure students were more likely to consume inadequate amounts of vitamins and minerals, especially antioxidants that are important in supporting the immune system. Food insecurity has been identified as affecting the majority of HIV-infected students in this study, especially regarding their difficulty in accessing nutritious foods. As overweight and obesity also seem to threaten the health and future well-being of the students, appropriate management of the overweight individuals and those with obesity should be instituted in order to prevent the development

  5. Transcriptional network analysis in frontal cortex in Lewy body diseases with focus on dementia with Lewy bodies.

    PubMed

    Santpere, Gabriel; Garcia-Esparcia, Paula; Andres-Benito, Pol; Lorente-Galdos, Belen; Navarro, Arcadi; Ferrer, Isidro

    2017-03-21

    The present study investigates global transcriptional changes in frontal cortex area 8 in incidental Lewy Body disease (iLBD), Parkinson disease (PD) and Dementia with Lewy bodies (DLB). We identified different co-expressed gene sets associated with disease stages, and gene ontology categories enriched in gene modules and differentially expressed genes including modules or gene clusters correlated to iLBD comprising upregulated dynein genes and taste receptors, and down-regulated innate inflammation. Focusing on DLB, we found modules with genes significantly enriched in functions related to RNA and DNA production, mitochondria and energy metabolism, purine metabolism, chaperone and protein folding system, and synapses and neurotransmission (particularly the GABAergic system). The expression of more than fifty selected genes was assessed with RT-qPCR. Our findings provide, for the first time, evidence of molecular cortical alterations in iLBD and involvement of several key metabolic pathways and gene hubs in DLB which may underlie cognitive impairment and dementia. This article is protected by copyright. All rights reserved.

  6. Streptococcal cell wall-induced arthritis and adjuvant arthritis in F344----Lewis and in Lewis----F344 bone marrow chimeras

    SciTech Connect

    van Bruggen, M.C.; van den Broek, M.F.; van den Berg, W.B. )

    1991-09-01

    Streptococcal cell wall (SCW)-induced arthritis and adjuvant arthritis (AA) are rat models for chronic, erosive polyarthritis. Both models can be induced in susceptible Lewis rats, whereas F344 rats are resistant. In AA as well as in SCW arthritis, antigen-specific T lymphocytes have been demonstrated to be crucial for chronic disease. In this communication the authors describe their studies to probe the cellular mechanism responsible for the difference in susceptibility of Lewis and F344, using bone marrow chimeras. By transplanting bone marrow cells from F344 into lethally irradiated Lewis recipients, Lewis rats were rendered resistant to SCW arthritis induction. F344 rats reconstituted with Lewis bone marrow, i.e., Lewis----F344 chimeras, develop an arthritis upon SCW injection. For AA comparable results were obtained. These data suggest that both resistance and susceptibility to bacterium-induced chronic arthritis are mediated by hemopoietic/immune cells and that the recipiental environment does not influence the susceptibility to chronic joint inflammation.

  7. 75 FR 55313 - Final Environmental Impact Statement (FEIS) for Grow the Army Actions at Fort Lewis and the...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-09-10

    ... Lewis-McChord, WA 98433-9500. FOR FURTHER INFORMATION CONTACT: Mr. Bill Van Hoesen, Joint Base Lewis- McChord National Environmental Policy Act (NEPA) Coordinator, at (253) 966-1780 during normal...

  8. Carbocations as Lewis acid catalysts in Diels-Alder and Michael addition reactions.

    PubMed

    Bah, Juho; Franzén, Johan

    2014-01-20

    In general, Lewis acid catalysts are metal-based compounds that owe their reactivity to a low-lying empty orbital. However, one potential Lewis acid that has received negligible attention as a catalyst is the carbocation. We have demonstrated the potential of the carbocation as a highly powerful Lewis acid catalyst for organic reactions. The stable and easily available triphenylmethyl (trityl) cation was found to be a highly efficient catalyst for the Diels-Alder reaction for a range of substrates. Catalyst loadings as low as 500 ppm, excellent yields, and good endo/exo selectivities were achieved. Furthermore, by changing the electronic properties of the substituents on the tritylium ion, the Lewis acidity of the catalyst could be tuned to control the outcome of the reaction. The ability of this carbocation as a Lewis acid catalyst was also further extended to the Michael reaction.

  9. Exercise for Individuals with Lewy Body Dementia: A Systematic Review

    PubMed Central

    Inskip, Michael; Mavros, Yorgi; Sachdev, Perminder S.; Fiatarone Singh, Maria A.

    2016-01-01

    Background Individuals with Lewy body Dementia (LBD), which encompasses both Parkinson disease dementia (PDD) and Dementia with Lewy Bodies (DLB) experience functional decline through Parkinsonism and sedentariness exacerbated by motor, psychiatric and cognitive symptoms. Exercise may improve functional outcomes in Parkinson’s disease (PD), and Alzheimer’s disease (AD). However, the multi-domain nature of the LBD cluster of symptoms (physical, cognitive, psychiatric, autonomic) results in vulnerable individuals often being excluded from exercise studies evaluating physical function in PD or cognitive function in dementia to avoid confounding results. This review evaluated existing literature reporting the effects of exercise interventions or physical activity (PA) exposure on cluster symptoms in LBD. Methods A high-sensitivity search was executed across 19 databases. Full-length articles of any language and quality, published or unpublished, that analysed effects of isolated exercise/physical activity on indicative Dementia with Lewy Bodies or PD-dementia cohorts were evaluated for outcomes inclusive of physical, cognitive, psychiatric, physiological and quality of life measures. The protocol for this review (Reg. #: CRD42015019002) is accessible at http://www.crd.york.ac.uk/PROSPERO/. Results 111,485 articles were initially retrieved; 288 full articles were reviewed and 89.6% subsequently deemed ineligible due to exclusion of participants with co-existence of dementia and Parkinsonism. Five studies (1 uncontrolled trial, 1 randomized controlled trial and 3 case reports) evaluating 16 participants were included. Interventions were diverse and outcome homogeneity was low. Habitual gait speed outcomes were measured in 13 participants and increased (0.18m/s, 95% CI -0.02, 0.38m/s), exceeding moderate important change (0.14m/s) for PD cohorts. Other outcomes appeared to improve modestly in most participants. Discussion Scarce research investigating exercise in LBD

  10. Ransom, Religion, and Red Giants: C.S. Lewis and Fred Hoyle

    NASA Astrophysics Data System (ADS)

    Larsen, Kristine

    2010-01-01

    Famed fantasy writer C.S. Lewis (1898-1963) was known to friends as a well-read astronomy aficionado. However, this medieval scholar and Christian apologist embraced a pre-Copernican universe (with its astrological overtones) in his Chronicles of Narnia series and defended the beauty and relevance of the geocentric model in his final academic work, "The Discarded Image". In the "Ransom Trilogy” ("Out of the Silent Planet", "Perelandra", and "That Hideous Strength") philologist Ransom (loosely based on Lewis's close friend J.R.R. Tolkien) travels to Lewis's visions of Mars and Venus, where he interacts with intelligent extraterrestrials, battles with evil scientists, and aids in the continuation of extraterrestrial Christian values. In the final book, Ransom is joined by a handful of colleagues in open warfare against the satanic N.I.C.E. (National Institute for Coordinated Experiments). Geneticist and evolutionary biologist J.B.S. Haldane criticized Lewis for his scientifically inaccurate descriptions of the planets, and his disdain for the scientific establishment. Lewis responded to the criticism in essays of his own. Another of Lewis's favorite scientific targets was atheist Fred Hoyle, whom he openly criticized for anti-Christian statements in Hoyle's BBC radio series. Writer and Lewis friend Dorothy L. Sayers voiced her own criticism of Hoyle. In a letter, Lewis dismissed Hoyle as "not a great philosopher (and none of my scientific colleagues think much of him as a scientist.” Given Lewis's lack of respect for Hoyle, and use of creative license in describing the planets, and the flat-earth, "geocentric” Narnia, it is surprising that Lewis very carefully includes an astronomically correct description of red giants in two novels in the Narnia series ("The Magician's Nephew" and "The Last Battle"). This inclusion is even more curious given that Fred Hoyle is well-known as one of the pioneers in the field of stellar death and the properties of red giants.

  11. The NASA Lewis Research Center SBIR program: An assessment

    NASA Technical Reports Server (NTRS)

    Grimes, Hubert H.; Metzger, Marie E.; Kim, Walter S.

    1993-01-01

    An assessment was made of the NASA Lewis Small Business Innovation Research (SBIR) Program for the years 1983 to 1989. The assessment was based on the study of 99 Phase 1 contracts and 39 Phase 2 contracts. The overall impact of SBIR was found to be very positive, contributing strongly to many NASA programs. In addition, many successful efforts were commercialized benefiting the small business, federal agencies, and the aerospace industry. The program was evaluated in terms of contract quality, innovativeness, comparison to the state-of-the-art, achievement of goals, difficulty, and impact. Program difficulties were also identified, which could suggest possible program improvements. Much of the information gained in this assessment provided a basis for a SBIR data base which will be updated every year. This data base is computerized and will provide an excellent source of information about past SBIR efforts and company capabilities.

  12. Enhanced Attitude Control Experiment for SSTI Lewis Spacecraft

    NASA Technical Reports Server (NTRS)

    Maghami, Peoman G.

    1997-01-01

    The enhanced attitude control system experiment is a technology demonstration experiment on the NASA's small spacecraft technology initiative program's Lewis spacecraft to evaluate advanced attitude control strategies. The purpose of the enhanced attitude control system experiment is to evaluate the feasibility of designing and implementing robust multi-input/multi-output attitude control strategies for enhanced pointing performance of spacecraft to improve the quality of the measurements of the science instruments. Different control design strategies based on modern and robust control theories are being considered for the enhanced attitude control system experiment. This paper describes the experiment as well as the design and synthesis of a mixed H(sub 2)/H(sub infinity) controller for attitude control. The control synthesis uses a nonlinear programming technique to tune the controller parameters and impose robustness and performance constraints. Simulations are carried out to demonstrate the feasibility of the proposed attitude control design strategy. Introduction

  13. Design of the NASA Lewis 4-Port Wave Rotor Experiment

    NASA Technical Reports Server (NTRS)

    Wilson, Jack

    1997-01-01

    Pressure exchange wave rotors, used in a topping stage, are currently being considered as a possible means of increasing the specific power, and reducing the specific fuel consumption of gas turbine engines. Despite this interest, there is very little information on the performance of a wave rotor operating on the cycle (i.e., set of waves) appropriate for use in a topping stage. One such cycle, which has the advantage of being relatively easy to incorporate into an engine, is the four-port cycle. Consequently, an experiment to measure the performance of a four-port wave rotor for temperature ratios relevant to application as a topping cycle for a gas turbine engine has been designed and built at NASA Lewis. The design of the wave rotor is described, together with the constraints on the experiment.

  14. Lewis Carroll and psychoanalysis: why nothing adds up in wonderland.

    PubMed

    Lane, Christopher

    2011-08-01

    Each generation of psychoanalyst has found different things to value and sometimes to censure in Lewis Carroll's remarkable fiction and flights of fancy. But what does Carroll's almost 'surrealist' perspective in the Alice stories tell us about the rituals and symbols that govern life beyond Wonderland and Looking-Glass World? Arguing that Carroll's strong interest in meaning and nonsense in these and later works helps make the world strange to readers, the better to show it off-kilter, this essay focuses on Jacques Lacan's Carroll - the writer-logician who stressed, as Lacan did, the difficulty and price of adapting to the symbolic order. By reconsidering Lacan's 1966 homage to the eccentric Victorian, I argue that Carroll's insight into meaning and interpretation remains of key interest to psychoanalysts intent on hearing all that he had to say about psychic life.

  15. Disease-modifying therapeutic directions for Lewy-Body dementias

    PubMed Central

    Zhang, Qiang; Kim, Young-Cho; Narayanan, Nandakumar S.

    2015-01-01

    Dementia with Lewy bodies (DLB) is the second leading cause of dementia following Alzheimer's disease (AD) and accounts for up to 25% of all dementia. DLB is distinct from AD in that it involves extensive neuropsychiatric symptoms as well as motor symptoms, leads to enormous societal costs in terms of direct medical care and is associated with high financial and caregiver costs. Although, there are no disease-modifying therapies for DLB, we review several new therapeutic directions in treating DLB. We discuss progress in strategies to decrease the level of alpha-synuclein, to prevent the cell to cell transmission of misfolded alpha-synuclein, and the potential of brain stimulation in DLB. PMID:26347604

  16. Magnetic-field measurements for the Lewis Research Center cyclotron

    NASA Technical Reports Server (NTRS)

    Fessler, T. E.

    1973-01-01

    The magnetic field of the Lewis Center cyclotron was mapped by using a Hall-effect magnetic-field transducer. Main-field Fourier coefficients were determined on a polar mesh of 40 radii for each of seven levels of main-field coil current. Incremental fields for eight sets of trim coils and two sets of harmonic coils were also determined at four of these main-field levels. A stored-program, digital computer was used to perform the measurements. The process was entirely automatic; all data-taking and data-reduction activities were specified by the computer programs. A new method for temperature compensation of a Hall element was used. This method required no temperature control of the element. Measurements of the Hall voltage and Hall-element resistance were sufficient to correct for temperature effects.

  17. The NASA Lewis Strain Gauge Laboratory: An update

    NASA Technical Reports Server (NTRS)

    Hobart, H. F.

    1986-01-01

    Efforts continue in the development and evaluation of electrical resistance strain gauges of the thin film and small diameter wire type. Results obtained early in 1986 on some Chinese gauges and Kanthal A-1 gauges mounted on a Hastelloy-X substrate are presented. More recent efforts include: (1) the determination of the uncertainty in the ability to establish gauge factor, (2) the evaluation of sputtered gauges that were fabricated at Lewis, (3) an investigation of the efficacy of dual element temperature compensated gauges when using strain gauge alloys having large thermal coefficients of resistance, and (4) an evaluation of the practical methods of stabilizing gauges whose apparent strain is dependent on cooling rate (e.g., FeCrAl gauges).

  18. Lower hybrid emission diagnostics on the NASA Lewis bumpy torus

    NASA Technical Reports Server (NTRS)

    Mallavarpu, R.

    1977-01-01

    The feasibility of using RF emission near the lower hybrid frequency of the NASA Lewis Bumpy Torus plasma for diagnostic purposes is examined. The emission is detected using a spectrum analyzer and a 50 omega miniature coaxial antenna that is sensitive to the polarization of the incoming signal. The frequency shift of the lower hybrid emission peak is monitored as a function of the background pressure, electrode voltage, electrode ring configuration and the strength of the toroidal dc magnetic field. Simultaneous measurements of the average plasma density are made with a polarization diplexing microwave interferometer. Data derived from the experiment are discussed with reference to the following: (1) the strength of the dc magnetic field in the emitting region; (2) comparison of the lower hybrid plasma density with the average plasma density; and (3) validity of the cold plasma lower hybrid resonance formula in the high density operating regime of the bumpy torus plasma.

  19. NASA Lewis Research Center Workshop on Forced Response in Turbomachinery

    NASA Technical Reports Server (NTRS)

    Stefko, George L. (Compiler); Murthy, Durbha V. (Compiler); Morel, Michael (Compiler); Hoyniak, Dan (Compiler); Gauntner, Jim W. (Compiler)

    1994-01-01

    A summary of the NASA Lewis Research Center (LeRC) Workshop on Forced Response in Turbomachinery in August, 1993 is presented. It was sponsored by the following NASA organizations: Structures, Space Propulsion Technology, and Propulsion Systems Divisions of NASA LeRC and the Aeronautics and Advanced Concepts & Technology Offices of NASA Headquarters. In addition, the workshop was held in conjunction with the GUIde (Government/Industry/Universities) Consortium on Forced Response. The workshop was specifically designed to receive suggestions and comments from industry on current research at NASA LeRC in the area of forced vibratory response of turbomachinery blades which includes both computational and experimental approaches. There were eight presentations and a code demonstration. Major areas of research included aeroelastic response, steady and unsteady fluid dynamics, mistuning, and corresponding experimental work.

  20. Delayed blink reflex in dementia with Lewy bodies

    PubMed Central

    Bonanni, Laura; Anzellotti, Francesca; Varanese, Sara; Thomas, Astrid; Manzoli, Lamberto; Onofrj, Marco

    2007-01-01

    Blink reflexes (BR) to electric stimuli of the supraorbital nerve were recorded in 26 patients with dementia with Lewy bodies (DLB), 26 patients with multiple system atrophy, 26 patients with Parkinson's disease, with or without REM sleep behaviour disorder (RBD), and in 20 patients with Alzheimer's disease and 20 with progressive supranuclear palsy without RBD, and compared with recordings in 30 healthy controls. BR were significantly delayed (p<0.001) only in DLB patients in comparison with controls and with the other groups of patients; 14 (53.8%) patients had BR latency above 2 SD of the control mean, ranging from 36.1 to 46.3 ms. BR latency was not related to the presence of RBD, while a Spearman correlation rho of 0.68 was found for scores assessing the presence of cognitive fluctuations. R2 delay was prominently (71.5%) bilateral. PMID:17878193

  1. NASA Lewis Propulsion Systems Laboratory Customer Guide Manual

    NASA Technical Reports Server (NTRS)

    Soeder, Ronald H.

    1994-01-01

    This manual describes the Propulsion Systems Laboratory (PSL) at NASA Lewis Research Center. The PSL complex supports two large engine test cells (PSL-3 and PSL-4) that are capable of providing flight simulation to altitudes of 70,000 ft. Facility variables at the engine or test-article inlet, such as pressure, temperature, and Mach number (up to 3.0 for PSL-3 and up to 6.0 planned for PSL-4), are discussed. Support systems such as the heated and cooled combustion air systems; the altitude exhaust system; the hydraulic system; the nitrogen, oxygen, and hydrogen systems; hydrogen burners; rotating screen assemblies; the engine exhaust gas-sampling system; the infrared imaging system; and single- and multiple-axis thrust stands are addressed. Facility safety procedures are also stated.

  2. Transport Coefficients for the NASA Lewis Chemical Equilibrium Program

    NASA Technical Reports Server (NTRS)

    Svehla, Roger A.

    1995-01-01

    The new transport property data that will be used in the NASA Lewis Research Center's Chemical Equilibrium and Applications Program (CEA) is presented. It complements a previous publication that documented the thermodynamic and transport property data then in use. Sources of the data and a brief description of the method by which the data were obtained are given. Coefficients to calculate the viscosity, thermal conductivity, and binary interactions are given for either one, or usually, two temperature intervals, typically 300 to 1000 K and 1000 to 5000 K. The form of the transport equation is the same as used previously. The number of species was reduced from the previous database. Many species for which the data were estimated were eliminated from the database. Some ionneutral interactions were added.

  3. Lewy body dementia: the impact on patients and caregivers.

    PubMed

    Zweig, Yael R; Galvin, James E

    2014-01-01

    Lewy body dementia (LBD) is the second most common neurodegenerative dementia in older adults, yet there remains a delay in diagnosis that limits healthcare providers' ability to maximize therapeutic outcomes and enhance patient and caregiver quality of life. The impact of LBD on patients includes limiting the potential exposure to medications that may cause adverse outcomes, and addressing how the disease manifestations, such as autonomic features and behavior, affect quality of life. LBD impact on caregivers has been discussed to a greater degree in the literature, and there is clear evidence of caregiver burden and grief associated with disease manifestations. Other common caregiving concerns, such as access to care, prevention of hospitalization, managing behavior, and reviewing prognosis and nursing home placement, are important to comprehensively address the needs of patients with LBD and their caregivers.

  4. Lewis acid-assisted detection of nerve agents in water.

    PubMed

    Butala, Rahul R; Creasy, William R; Fry, Roderick A; McKee, Michael L; Atwood, David A

    2015-06-07

    The five-coordinate compound, Salen((t)Bu)Al(Ac), prepared in situ from Salen((t)Bu)AlBr and NH4Ac, forms Lewis acid-base adducts in aqueous solution with the G-type nerve agents, Sarin and Soman, and the VX hydrolysis product, ethylmethylphosphonate (EMPA). The resulting compounds, [Salen((t)Bu)Al(NA)](+)[Ac] (-) (with NA = Sarin, Soman, and EMPA) are sufficiently stable to be identified by ESI-MS. Molecular ion peaks were detected for every compound with little or no fragmentation. The distinctive MS signatures for the [Salen((t)Bu)Al(NA)](+) compounds provide a new technique for identifying nerve agents from aqueous solution. The energetics of the displacement of Ac(-) by the nerve agents to form [Salen((t)Bu)Al(NA)](+)[Ac](-) were determined computationally.

  5. The NASA Lewis integrated propulsion and flight control simulator

    NASA Technical Reports Server (NTRS)

    Bright, Michelle M.; Simon, Donald L.

    1991-01-01

    A new flight simulation facility was developed at NASA-Lewis. The purpose of this flight simulator is to allow integrated propulsion control and flight control algorithm development and evaluation in real time. As a preliminary check of the simulator facility capabilities and correct integration of its components, the control design and physics models for a short take-off and vertical landing fighter aircraft model were shown, with their associated system integration and architecture, pilot vehicle interfaces, and display symbology. The initial testing and evaluation results show that this fixed based flight simulator can provide real time feedback and display of both airframe and propulsion variables for validation of integrated flight and propulsion control systems. Additionally, through the use of this flight simulator, various control design methodologies and cockpit mechanizations can be tested and evaluated in a real time environment.

  6. [Diagnosis and treatment of multifocal motor neuropathy (Lewis-Sumner)].

    PubMed

    Kaji, R

    1999-01-01

    We made a retrospective long-term follow-up study of 25 patients with multifocal motor neuropathy (Lewis-Sumner). The diagnosis was based upon criteria modified from those of AAEM (Sumner 1997). The electrophysiological findings indicating conduction block or focal demyelinative lesions were more diagnostic than anti-GM 1 antibody titers, which were elevated in only 40% of these patients. Demonstration of definite conduction block was not always possible in those patients who responded favorably to intravenous immunoglobulins (IVIg), whereas indirect pieces of evidence such as F-wave abnormalities or focal conduction delay or dispersion were equally helpful. IVIg had superior outcome to cyclophosphamide, which sometimes caused serious adverse effects. Three patients with severe axonal involvement showed elevated monospecific antibodies to GalNAc-GD1a.

  7. Microfluidic Separation of Ethylene and Ethane Using Frustrated Lewis Pairs.

    PubMed

    Voicu, Dan; Stephan, Douglas W; Kumacheva, Eugenia

    2015-12-21

    Separation of gaseous olefins and paraffins is one of the most important separation processes in the industry. Development of new cost-effective technologies aims at reducing the high energy consumption during the separation process. Here, we took advantage of the reaction of frustrated Lewis pairs (FLPs) with ethylene to achieve reactive extraction of ethylene from ethylene-ethane mixtures. The extraction was studied using a microfluidic platform, which enabled a rapid, high-throughput assessment of reaction conditions to optimize gas separation efficiency. A separation factor of 7.3 was achieved for ethylene from a 1:1 volume ratio mixture of ethylene and ethane, which corresponded to an extracted ethylene purity of 88 %. The results obtained in the microfluidic studies were validated using infrared spectroscopy. This work paves the way for further development of the FLPs and optimization of reaction conditions, thereby maximizing the separation efficiency of olefins from their mixtures with paraffins.

  8. Association of Glucocerebrosidase Mutations With Dementia With Lewy Bodies

    PubMed Central

    Clark, Lorraine N.; Kartsaklis, Lykourgos A.; Wolf Gilbert, Rebecca; Dorado, Beatriz; Ross, Barbara M.; Kisselev, Sergey; Verbitsky, Miguel; Mejia-Santana, Helen; Cote, Lucien J.; Andrews, Howard; Vonsattel, Jean-Paul; Fahn, Stanley; Mayeux, Richard; Honig, Lawrence S.; Marder, Karen

    2009-01-01

    Background Mutations in the glucocerebrosidase (GBA) gene are associated with Lewy body (LB) disorders. Objective To determine the relationship of GBA mutations and APOE4 genotype to LB and Alzheimer disease (AD) pathological findings. Design Case-control study. Setting Academic research. Participants The 187 subjects included patients with primary neuropathological diagnoses of LB disorders with or without AD changes (95 cases), randomly selected patients with AD (without significant LB pathological findings; 60 cases), and controls with neither LB nor AD pathological findings (32 cases). Main Outcome Measures GBA mutation status, APOE4 genotype, LB pathological findings (assessed according to the third report of the Dementia With Lewy Body Consortium), and Alzheimer plaque and tangle pathological findings (rated by criteria of Braak and Braak, the Consortium to Establish a Registry for Alzheimer Disease, and the National Institute on Aging–Reagan Institute). Results GBA mutations were found in 18% (34 of 187) of all subjects, including 28% (27 of 95) of those with primary LB pathological findings compared with 10% (6 of 60) of those with AD pathological findings and 3% (1 of 32) of those without AD or LB pathological findings (P=.001). GBA mutation status was significantly associated with the presence of cortical LBs (odds ratio, 6.48; 95% confidence interval, 2.45–17.16; P<.001), after adjusting for sex, age at death, and presence of APOE4. GBA mutation carriers were significantly less likely to meet AD pathological diagnostic (National Institute on Aging–Reagan Institute intermediate or high likelihood) criteria (odds ratio, 0.35; 95% confidence interval, 0.15–0.79; P=.01) after adjustment for sex, age at death, and APOE4. Conclusion GBA mutations may be associated with pathologically “purer” LB disorders, characterized by more extensive (cortical) LB, and less severe AD pathological findings and may be a useful marker for LB disorders. PMID

  9. Mars Pathfinder Rover-Lewis Research Center Technology Experiments Program

    NASA Technical Reports Server (NTRS)

    Stevenson, Steven M.

    1997-01-01

    An overview of NASA's Mars Pathfinder Program is given and the development and role of three technology experiments from NASA's Lewis Research Center and carried on the Mars Pathfinder rover is described. Two recent missions to Mars were developed and managed by the Jet Propulsion Laboratory, and launched late last year: Mars Global Surveyor in November 1996 and Mars Pathfinder in December 1996. Mars Global Surveyor is an orbiter which will survey the planet with a number of different instruments, and will arrive in September 1997, and Mars Pathfinder which consists of a lander and a small rover, landing on Mars July 4, 1997. These are the first two missions of the Mars Exploration Program consisting of a ten year series of small robotic martian probes to be launched every 26 months. The Pathfinder rover will perform a number of technology and operational experiments which will provide the engineering information necessary to design and operate more complex, scientifically oriented surface missions involving roving vehicles and other machinery operating in the martian environment. Because of its expertise in space power systems and technologies, space mechanisms and tribology, Lewis Research Center was asked by the Jet Propulsion Laboratory, which is heading the Mars Pathfinder Program, to contribute three experiments concerning the effects of the martian environment on surface solar power systems and the abrasive qualities of the Mars surface material. In addition, rover static charging was investigated and a static discharge system of several fine Tungsten points was developed and fixed to the rover. These experiments and current findings are described herein.

  10. Experimental allergic encephalomyelitis in pituitary-grafted Lewis rats

    PubMed Central

    Esquifino, Ana I; Cano, Pilar; Zapata, Agustín; Cardinali, Daniel P

    2006-01-01

    Treatment of susceptible rats with dopaminergic agonists that reduce prolactin release decreases both severity and duration of clinical signs of experimental allergic encephalomyelitis (EAE). To assess to what extent the presence of an ectopic pituitary (that produces an increase in plasma prolactin levels mainly derived from the ectopic gland) affects EAE, 39 male Lewis rats were submitted to pituitary grafting from littermate donors. Another group of 38 rats was sham-operated by implanting a muscle fragment similar in size to the pituitary graft. All rats received subcutaneous (s.c.) injections of complete Freund's adjuvant (CFA) plus spinal cord homogenate (SCH) and were monitored daily for clinical signs of EAE. Animals were killed by decapitation on days 1, 4, 7, 11 or 15 after immunization and plasma was collected for prolactin RIA. In a second experiment, 48 rats were immunized by s.c. injection of a mixture of SCH and CFA, and then received daily s.c. injections of bromocriptine (1 mg/kg) or saline. Groups of 8 animals were killed on days 8, 11 or 15 after immunization and plasma prolactin was measured. Only sham-operated rats exhibited clinical signs of the disease when assessed on day 15 after immunization. A progressive decrease in plasma prolactin levels was observed in pituitary-grafted rats, attaining a minimum 15 days after immunization, whereas plasma prolactin levels were increased during the course of the disease in sham-operated rats. Plasma prolactin levels were higher in pituitary-grafted rats than in sham-operated rats 1 day after immunization, but lower on days 7, 11 and 15 after immunogen injection. Further supporting a correlation of suppressed prolactin levels with absence of clinical signs of EAE, rats that were administered the dopaminergic agonist bromocriptine showed very low plasma prolactin levels and did not exhibit any clinical sign of EAE. These results indicate that low circulating prolactin levels coincide with absence of

  11. Columbia River Fishes of the Lewis and Clark Expedition

    SciTech Connect

    Dauble, Dennis D.

    2007-06-21

    The Lewis and Clark expedition crossed the Continental Divide in 1805 on the way west to the Pacific Ocean. Based on journal entries, members of the expedition probably encountered two species of resident salmonids and four of the six species of anadromous salmonids and steelhead (Family Salmonidae, genus Oncorhynchus). The salmonid species were called common salmon (now known as Chinook salmon O. tshawytscha), red char (sockeye salmon O.nerka) white salmon trout (coho salmon [also known as silver salmon] O. kisutch), salmon trout (steelhead O. mykiss), and spotted trout (cutthroat trout O. clarkii). There was no evidence of the expedition encountering pink salmon O. gorbuscha, chum salmon O. keta, or species of true char Salvelinus spp. Common fishes procured from Indian tribes living along the lower Columbia River included eulachon Thaleichthys pacificus and white sturgeon Acipenser transmontanus. The identity of three additional resident freshwater species is questionable. Available descriptions suggest that what they called mullet were largescale sucker Catastomus macrocheilus, and that chubb were peamouth Mylocheilus caurinus. The third questionable fish, which they called bottlenose, was probably mountain whitefish Prosopium williamsoni, although there is no evidence that the species was observed in the Columbia River drainage. Missing from the species list were more than 20 other fishes known to Sahaptin-speaking people from the mid-Columbia region. More complete documentation of the icthyofauna of the Pacific Northwest region did not occur until the latter half of the 19th century. However, journals from the Lewis and Clark expedition provide the first documentation of Columbia River fishes.

  12. Mars Pathfinder Rover-Lewis Research Center Technology Experiments Program

    NASA Astrophysics Data System (ADS)

    Stevenson, Steven M.

    1997-07-01

    An overview of NASA's Mars Pathfinder Program is given and the development and role of three technology experiments from NASA's Lewis Research Center and carried on the Mars Pathfinder rover is described. Two recent missions to Mars were developed and managed by the Jet Propulsion Laboratory, and launched late last year: Mars Global Surveyor in November 1996 and Mars Pathfinder in December 1996. Mars Global Surveyor is an orbiter which will survey the planet with a number of different instruments, and will arrive in September 1997, and Mars Pathfinder which consists of a lander and a small rover, landing on Mars July 4, 1997. These are the first two missions of the Mars Exploration Program consisting of a ten year series of small robotic martian probes to be launched every 26 months. The Pathfinder rover will perform a number of technology and operational experiments which will provide the engineering information necessary to design and operate more complex, scientifically oriented surface missions involving roving vehicles and other machinery operating in the martian environment. Because of its expertise in space power systems and technologies, space mechanisms and tribology, Lewis Research Center was asked by the Jet Propulsion Laboratory, which is heading the Mars Pathfinder Program, to contribute three experiments concerning the effects of the martian environment on surface solar power systems and the abrasive qualities of the Mars surface material. In addition, rover static charging was investigated and a static discharge system of several fine Tungsten points was developed and fixed to the rover. These experiments and current findings are described herein.

  13. Alcohol consumption, Lewis phenotypes, and risk of ischemic heart disease

    SciTech Connect

    Hein, H.O.; Suadicani, P.; Gyntelberg, F. . Epidemiological Research Unit); Sorenson, H. . Dept. of Chemical Immunology); Hein, H.O. . Dept. of Internal Medicine)

    1993-02-13

    The authors have previously found an increased risk of ischemic heart disease (IHD) in men with the Lewis phenotype Le(a[minus]b[minus]) and suggested that the Lewis blood group has a close genetic relation with insulin resistance. The authors have investigated whether any conventional risk factors explain the increased risk in Le(a[minus]b[minus]) men. 3,383 men aged 53-75 years were examined in 1985-86, and morbidity and mortality during the next 4 years were recorded. At baseline, the authors excluded 343 men with a history of myocardial infarction, angina pectoris, intermittent claudication, or stroke. The potential risk factors examined were alcohol consumption, physical activity, tobacco smoking, serum cotinine, serum lipids, body-mass index, blood pressure, prevalence of hypertension and non-insulin-dependent diabetes mellitus, and social class. In 280 (9.6%) men with Le(a[minus]b[minus]), alcohol was the only risk factor significantly associated with risk of IHD. There was a significant inverse dose-effect relation between alcohol consumption and risk; trend tests, with adjustment for age, were significant for fatal IHD (p=0.02), all IHD (p=0.03), and all causes of death (p=0.02). In 2649 (90.4%) men with other phenotypes, there was a limited negative association with alcohol consumption. In Le(a[minus]b[minus]) men, a group genetically at high risk of IHD, alcohol consumption seems to be especially protective. The authors suggest that alcohol consumption may modify insulin resistance in Le(a[minus]b[minus]) men.

  14. Structural characterization of the DC-SIGN-Lewis(X) complex.

    PubMed

    Pederson, Kari; Mitchell, Daniel A; Prestegard, James H

    2014-09-09

    Dendritic cell-specific intracellular adhesion molecule-3-grabbing nonintegrin (DC-SIGN) is a C-type lectin highly expressed on the surface of antigen-presenting dendritic cells. DC-SIGN mediates interactions among dendritic cells, pathogens, and a variety of epithelia, myeloid cells, and endothelia by binding to high mannose residues on pathogenic invaders or fucosylated residues on the membranes of other immune cells. Although these interactions are normally beneficial, they can also contribute to disease. The structural characterization of binding geometries is therefore of interest as a basis for the construction of mimetics that can mediate the effects of abnormal immune response. Here, we report the structural characteristics of the interaction of the DC-SIGN carbohydrate recognition domain (CRD) with a common fucosylated entity, the Lewis(X) trisaccharide (Le(X)), using NMR methods. Titration of the monomeric DC-SIGN CRD with Le(X) monitored by 2D NMR revealed significant perturbations of DC-SIGN cross-peak positions in (1)H-(15)N heteronuclear single quantum coherence (HSQC) spectra and identified residues near the binding site. Additionally, saturation transfer difference (STD) and transferred nuclear Overhauser effect (trNOE) NMR experiments, using a tetrameric form of DC-SIGN, identified binding epitopes and bound conformations of the Le(X) ligand. The restraints derived from these multiple experiments were used to generate models for the binding of Le(X) to the DC-SIGN CRD. Ranking of the models based on the fit of model-based simulations of the trNOE data and STD buildup curves suggested conformations distinct from those seen in previous crystal structures. The new conformations offer insight into how differences between binding of Lewis(X) and mannose-terminated saccharides may be propagated.

  15. An in vitro investigation to compare the surface roughness of auto glazed, reglazed and chair side polished surfaces of Ivoclar and Vita feldspathic porcelain.

    PubMed

    Sethi, Sumit; Kakade, Dilip; Jambhekar, Shantanu; Jain, Vinay

    2013-12-01

    The change in surface roughness after different surface finishing techniques has attracted the attention of several prosthodontists regarding wear of opposing teeth or restorative material and the strength; plaque retention and appearance of the restoration. However, there is considerable controversy concerning the best methods to achieve the smoothest and strongest porcelain restorations after chair side clinical adjustments. The purpose of this in vitro study was to compare the average surface roughness of a self-glazed surface, a chair side polished surface and a reglazed surface of ceramic. Two feldspathic porcelain, namely VITA VMK94 (Vita Zahnfabrik, Bad Sachingen, Germany) and IVOCLAR CLASSIC (Vivadent AG, FL-9494 Schaan, Liechtenstein) were selected to fabricate 20 specimens of each in the shape of shade guide tabs. A medium-grit diamond rotary cutting instrument was used to remove the glaze layer, and then the surface of half the specimens were re-glazed and the other half were polished using a well-defined sequence of polishing comprising of: Shofu porcelain polishing system, White gloss disc/polishing wheel, Silicone cone with diamond polishing paste and finally with small buff wheel with pumice slurry. The surface roughness (Ra) (μm) of the specimens was evaluated using a profilometer and scanning electron microscope. The data were statistically analyzed by using Student's t test. The results had shown that there is no statistically significant difference both quantitatively and qualitatively, between the surface roughness of reglazed and chair-side polished surface. In addition, both reglazed and chair-side polished surfaces are better than the autoglazed surface. Within all the groups, there is no significant difference between companies. Polishing an adjusted porcelain surface with the suggested sequence of polishing will lead to a finish similar to a re-glazed surface. Therefore chair-side polishing can be a good alternative to reglazing for

  16. In Vivo and in Vitro Evaluations of Repeatability and Accuracy of VITA Easyshade® Advance 4.0 Dental Shade-Matching Device

    PubMed Central

    Illeš, Iva Ž.; Alajbeg, Maja; Žagar

    2015-01-01

    Objectives The objective of this study was to evaluate the intra-device repeatability and accuracy of dental shade-matching device (VITA Easyshade® Advance 4.0) using both in vitro and in vivo models. Materials and methods For the repeatability assessment, the in vivo model utilized shade-matching device to measure the central region of the labial surface of right maxillary central incisors of 10 people twice. The following tooth colors were measured: B1, A1, A2, A3, C1 and C3. The in vitro model included the same six Vitapan Classical tabs. Two measurements were made of the central region of each shade tab. For the accuracy assessment, each shade tab from 3 Vitapan Classical shade guides was measured once. CIE L*a*b* values were determined. Intraclass correlation coefficients (ICCs) were used to analyze the in vitro and in vivo intra-device repeatability of the shade-matching device. The difference between in vitro and in vivo models was analyzed. Accuracy of the device tested was calculated. Results The mean color differences for in vivo and in vitro models were 3.51 and 1.25 E units, respectively. The device repeatability ICCs for in vivo measurements ranged from 0.858 to 0.971 and for in vitro from 0.992 to 0.994. Accuracy of the device tested was 93.75%. Conclusion Within the limitations of the experiment, VITA Easyshade®Advance 4.0 dental shade-matching device enabled reliable and accurate measurement. It can be a valuable tool for the determination of tooth colours. PMID:27688393

  17. Lewis pair polymerization by classical and frustrated Lewis pairs: acid, base and monomer scope and polymerization mechanism.

    PubMed

    Zhang, Yuetao; Miyake, Garret M; John, Mallory G; Falivene, Laura; Caporaso, Lucia; Cavallo, Luigi; Chen, Eugene Y-X

    2012-08-14

    Classical and frustrated Lewis pairs (LPs) of the strong Lewis acid (LA) Al(C(6)F(5))(3) with several Lewis base (LB) classes have been found to exhibit exceptional activity in the Lewis pair polymerization (LPP) of conjugated polar alkenes such as methyl methacrylate (MMA) as well as renewable α-methylene-γ-butyrolactone (MBL) and γ-methyl-α-methylene-γ-butyrolactone (γ-MMBL), leading to high molecular weight polymers, often with narrow molecular weight distributions. This study has investigated a large number of LPs, consisting of 11 LAs as well as 10 achiral and 4 chiral LBs, for LPP of 12 monomers of several different types. Although some more common LAs can also be utilized for LPP, Al(C(6)F(5))(3)-based LPs are far more active and effective than other LA-based LPs. On the other hand, several classes of LBs, when paired with Al(C(6)F(5))(3), can render highly active and effective LPP of MMA and γ-MMBL; such LBs include phosphines (e.g., P(t)Bu(3)), chiral chelating diphosphines, N-heterocyclic carbenes (NHCs), and phosphazene superbases (e.g., P(4)-(t)Bu). The P(4)-(t)Bu/Al(C(6)F(5))(3) pair exhibits the highest activity of the LP series, with a remarkably high turn-over frequency of 9.6 × 10(4) h(-1) (0.125 mol% catalyst, 100% MMA conversion in 30 s, M(n) = 2.12 × 10(5) g mol(-1), PDI = 1.34). The polymers produced by LPs at RT are typically atactic (P(γ)MMBL with ∼47% mr) or syndio-rich (PMMA with ∼70-75% rr), but highly syndiotactic PMMA with rr ∼91% can be produced by chiral or achiral LPs at -78 °C. Mechanistic studies have identified and structurally characterized zwitterionic phosphonium and imidazolium enolaluminates as the active species of the current LPP system, which are formed by the reaction of the monomer·Al(C(6)F(5))(3) adduct with P(t)Bu(3) and NHC bases, respectively. Kinetic studies have revealed that the MMA polymerization by the (t)Bu(3)P/Al(C(6)F(5))(3) pair is zero-order in monomer concentration after an initial

  18. Surface properties of turbulent premixed propane/air flames at various Lewis numbers

    SciTech Connect

    Lee, T.W.; North, G.L.; Santavicca, D.A. )

    1993-06-01

    Surface properties of turbulent premixed flames including the wrinkled flame perimeter, fraction of the flame pocket perimeter, flame curvature, and orientation distributions have been measured for propane-air flames at Lewis numbers ranging from 0.98 to 1.86 and u[prime]/S[sub L] = 1.42-5.71. The wrinkled flame perimeter is found to be greater for the thermodiffusively unstable Lewis number (Le < 1) by up to 30% in comparison to the most stable condition (Le = 1.86) tested, while the fraction of the flame pocket perimeter shows a similar tendency to be greater for Le < 1. The flame curvature probability density functions are nearly symmetric with respect to the zero mean at all Lewis numbers throughout the range of u[prime]/S[sub L] tested, and show a much stronger dependence on the turbulence condition than on the Lewis number. Similarly, the flame orientation distributions show a trend from anisotropy toward a more uniform distribution with increasing u[prime]/S[sub L] at a similar rate for all Lewis numbers. Thus, for turbulent premixed propane/air flames for a practical range of Lewis number from 0.98 to 1.86, the effect of Lewis number is primarily to affect the flame structures and thereby flame surface areas and flame pocket areas, while the flame curvature and orientation statistics are essentially determined by the turbulence properties.

  19. Highly Lewis Acidic Arylboronate Esters Capable of Colorimetric Turn-On Response.

    PubMed

    Oehlke, Alexander; Auer, Alexander A; Schreiter, Katja; Friebe, Nadine; Spange, Stefan

    2015-12-01

    A series of boronate-π-acceptor compounds containing different types of π bridges (1,4-phenylen or thien-2,5-diyl or furan-2,5-diyl) that link the switchable boronate ester group with the efficient TCF acceptor group (TCF=2-dicyanomethylen-3-cyano-4,5,5-trimethyl-2,5-dihydrofuran) has been synthesized. A TCF chromophore of this type undergoes transition to a donor-π-acceptor compound upon coordination of Lewis bases at the Lewis acidic boron center, which is accompanied by an enhanced intramolecular charge-transfer interaction. The Lewis acid character has been investigated by spectroscopic measurements (UV/Vis, NMR spectroscopies) as well as DFT and ab initio-based calculations. It is shown that the TCF acceptor group and thiophene or furan π-bridges directly bound to the boron atom cooperatively increase the Lewis acidity. UV/Vis titration experiments confirm fluoride binding constants in the range of up to 10(8)  M(-1) in CH2 Cl2 . In addition to the strong boron fluoride binding motif, Lewis interactions also occur with weaker Lewis bases, such as pyridine or aliphatic alcohols. The unique combination of chromophoric and Lewis acidic properties is responsible for the intense colorimetric turn-on response detectable after complex formation.

  20. Conceptual quantum chemical analysis of bonding and noncovalent interactions in the formation of frustrated Lewis pairs.

    PubMed

    Skara, Gabriella; Pinter, Balazs; Top, Jens; Geerlings, Paul; De Proft, Frank; De Vleeschouwer, Freija

    2015-03-27

    The contributions of covalent and noncovalent interactions to the formation of classical adducts of bulky Lewis acids and bases and frustrated Lewis pairs (FLPs) were scrutinized by using various conceptual quantum chemical techniques. Significantly negative complexation energies were calculated for fourteen investigated Lewis pairs containing bases and acids with substituents of various sizes. A Ziegler-Rauk-type energy decomposition analysis confirmed that two types of Lewis pairs can be distinguished on the basis of the nature of the primary interactions between reactants; dative-bond formation and concomitant charge transfer from the Lewis base to the acid is the dominant and most stabilizing factor in the formation of Lewis acid-base adducts, whereas weak interactions are the main thermodynamic driving force (>50 %) for FLPs. Moreover, the ease and extent of structural deformation of the monomers appears to be a key component in the formation of the former type of Lewis pairs. A Natural Orbital for Chemical Valence (NOCV) analysis, which was used to visualize and quantify the charge transfer between the base and the acid, clearly showed the importance and lack of this type of interaction for adducts and FLPs, respectively. The Noncovalent Interaction (NCI) method revealed several kinds of weak interactions between the acid and base components, such as dispersion, π-π stacking, C-H⋅⋅⋅π interaction, weak hydrogen bonding, halogen bonding, and weak acid-base interactions, whereas the Quantum Theory of Atoms in Molecules (QTAIM) provided further conceptual insight into strong acid-base interactions.

  1. Biosynthesis and distribution of Lewis X- and Lewis Y-containing glycoproteins in the murine male reproductive system.

    PubMed

    Wang, Chunmei; Huang, Chengyang; Gu, Yihua; Zhou, Yuchuan; Zhu, Zhengmei; Zhang, Yonglian

    2011-02-01

    Although Lewis X (LeX) and Lewis Y (LeY) antigens were thought to play important roles in fertility, fucosyltransferase (Fut)-deficient (Fut1, Fut2 and Fut4) mice which lack LeX or LeY antigen are still fertile. In the present study, the Fut-deficient and wild-type mice were used to measure the expression of Fut mRNA along the mouse male reproductive tract and determine the role of each Fut in the biosynthesis of LeX/LeY antigens, which are conjugated to glycoproteins in the male reproductive system. LeX/LeY-containing glycoproteins were detected in the epididymis, vas deferens, seminal vesicle and coagulating gland, but not in the testis. We demonstrate that the synthesis of LeY-containing glycoproteins in the epididymis and vas deferens is catalyzed by Fut1 and Fut4. In the seminal vesicle and the coagulating gland, they are mainly synthesized by Fut2 and an α-(1,3)-Fut, but not Fut4. The synthesis of LeX-containing glycoproteins in the middle caput epididymis is catalyzed by Fut4 and by Fut4 and Fut2 in the seminal vesicle. We provide evidence that LeX is synthesized in the coagulating gland by Fut9. We found that the lack of activity by one Fut does not completely inhibit LeX/LeY antigen expression in the male reproductive tract. This redundancy may help to explain why in vivo studies with Fut-deficient mice do not support the presumption that LeX/LeY antigens play important roles in male fertility. We provide details regarding the phenotypes of established Fut-deficient mice and lay the foundation for elucidating the functions of LeX/LeY antigens in other aspects of the male reproductive system.

  2. Diagnostic value of minor salivary glands biopsy for the detection of Lewy pathology.

    PubMed

    Folgoas, Emmanuelle; Lebouvier, Thibaud; Leclair-Visonneau, Laurène; Cersosimo, Maria-Graciela; Barthelaix, Annick; Derkinderen, Pascal; Letournel, Franck

    2013-09-13

    The recent demonstration of the presence of Lewy pathology in the submandibular glands of Parkinson's disease (PD) patients prompted us to evaluate the diagnostic performance of minor salivary gland biopsy for PD. Minor salivary glands were examined for Lewy pathology using phosphorylated alpha-synuclein antibody in 16 patients with clinically diagnosed PD and 11 control subjects with other neurological disorders. Abnormal accumulation of alpha-synuclein was found in 3 out of 16 PD patients. Two control subjects exhibited weak phosphorylated alpha-synuclein immunoreactivity. Our results do not support the use of minor salivary glands biopsy for the detection of Lewy pathology in living subjects.

  3. Plans and status of the NASA-Lewis Research Center wind energy project

    NASA Technical Reports Server (NTRS)

    Thomas, R.; Puthoff, R.; Savino, J.; Johnson, W.

    1975-01-01

    This report describes that portion of the national five-year wind energy program that is being managed by the NASA-Lewis Research Center for the ERDA. The Lewis Research Center's Wind Power Office, its organization and plans and status are briefly described. The three major elements of the wind energy project at Lewis are the experimental 100 kW wind-turbine generator; the first generation industry-built and user-operated wind turbine generators; and the supporting research and technology tasks which are each briefly described.

  4. Emerging pathways in genetic Parkinson's disease: Potential role of ceramide metabolism in Lewy body disease.

    PubMed

    Bras, Jose; Singleton, Andrew; Cookson, Mark R; Hardy, John

    2008-12-01

    Heterozygous loss-of-function mutations at the glucosecerebrosidase locus have recently been shown to be a potent risk factor for Lewy body disease. Based on this observation, we have re-evaluated the likelihood that the different PARK loci (defined using clinical criteria for disease) may be misleading attempts to find common pathways to pathogenesis. Rather, we suggest, grouping the different loci which lead to different Lewy body disease may be more revealing. Doing this, we suggest that several of the genes involved in disparate Lewy body diseases impinge on ceramide metabolism and we suggest that this may be a common theme for pathogenesis.

  5. Rapid Dihydrogen Cleavage by Persistent Nitroxide Radicals under Frustrated Lewis Pair Conditions.

    PubMed

    Tao, Xin; Kehr, Gerald; Wang, Xiaowu; Daniliuc, Constantin G; Grimme, Stefan; Erker, Gerhard

    2016-07-04

    Persistent radicals undergo hydrogen atom abstraction reactions with a great variety of substrates, but not with dihydrogen. It has now been found that the TEMPO radical splits dihydrogen under mild conditions in the presence of the strong bulky B(C6 F5 )3 boron Lewis acid. The reaction is thought to proceed by a typical frustrated Lewis pair mechanism with the TEMPO radical acting as the active Lewis base. The reaction was analyzed by DFT, which indicates that no significant spin density on the hydrogen atoms is accumulated along the H2 splitting reaction path.

  6. Understanding the Role of Dispersion in Frustrated Lewis Pairs and Classical Lewis Adducts: A Domain-Based Local Pair Natural Orbital Coupled Cluster Study.

    PubMed

    Bistoni, Giovanni; Auer, Alexander A; Neese, Frank

    2017-01-18

    The interaction of Lewis acids and bases in both classical Lewis adducts and frustrated Lewis pairs (FLPs) is investigated to elucidate the role that London dispersion plays in different situations. The analysis comprises 14 different adducts between tris(pentafluorophenyl)borane and a series of phosphines, carbenes, and amines with various substituents, differing in both steric and electronic properties. The domain-based local pair natural orbital coupled-cluster (DLPNO-CCSD(T)) method is used in conjunction with the recently introduced local energy decomposition (LED) analysis to obtain state-of-the-art dissociation energies and, at the same time, a clear-cut definition of the London dispersion component of the interaction, with the ultimate goal of aiding in the development of designing principles for acid/base pairs with well-defined bonding features and reactivity. In agreement with previous DFT investigations, it is found that the London dispersion dominates the interaction energy in FLPs, and is also remarkably strong in Lewis adducts. In these latter systems, its magnitude can be easily modulated by modifying the polarizability of the substituents on the basic center, which is consistent with the recently introduced concept of dispersion energy donors. By counteracting the destabilizing energy contribution associated with the deformation of the monomers, the London dispersion drives the stability of many Lewis adducts.

  7. Survey on Cosmogenic 26Al in Lewis Cliff Meteorites

    NASA Astrophysics Data System (ADS)

    Welten, K. C.; Alderliesten, C.; Lindner, L.

    1992-07-01

    INTRODUCTION: We have embarked upon a ^26Al gamma-ray survey of meteorites selected from about 2000 samples recently recovered from the Lewis Cliff Ice Fields (84 degrees 18'S/161 degrees 20'E). Due to its 705-ka half-life ^26Al can be used for estimating terrestrial ages and thus contribute to further characterization of Antarctic meteorites in addition to their classification and thermoluminescence (TL) properties. The ^26Al survey is also useful for identifying meteorites with unusual exposure histories, which merit additional measurements of cosmogenic radionuclides (by AMS) and noble gases. In addition, it provides clues on possible pairings. METHOD: Low-level gamma-ray spectroscopy is well suited for ^26Al survey work, since bulk meteorite samples can be measured routinely and nondestructively without any previous sample preparation. The required size of the samples (30-500 g) makes the method relatively independent of depth effects and compositional inhomogeneities. The use of a high-resolution GeLi detector also allows the determination of the natural ^40K activity and thus the K content of the samples, which can be used as an additional pairing criterion for ordinary chondrites. Also ^137Cs, a fall-out surface contamination [1], is simultaneously measured; low values may be characteristic for meteorites recently fallen or released from the ablating ice. For the detector an efficiency calibration curve has been made that adequately accounts for differences in size and shape of the meteorite samples. RESULTS and DISCUSSION: TERRESTRIAL AGES: So far, we have measured over 30 Lewis Cliff equilibrated H and L chondrites, collected from widely differing locations. Normalized to L-chondrite composition, the ^26Al contents range from 27 to 110 dpm/kg with peaks around 43 and 53 dpm/kg. This bimodal ^26Al distribution is reminiscent of that observed for Allan Hills ordinary chondrites [2]. Tentative terrestrial ages, calculated on the basis of ^26Al saturation

  8. A comparison of two instructional methods for drawing Lewis Structures

    NASA Astrophysics Data System (ADS)

    Terhune, Kari

    Two instructional methods for teaching Lewis structures were compared -- the Direct Octet Rule Method (DORM) and the Commonly Accepted Method (CAM). The DORM gives the number of bonds and the number of nonbonding electrons immediately, while the CAM involves moving electron pairs from nonbonding to bonding electrons, if necessary. The research question was as follows: Will high school chemistry students draw more accurate Lewis structures using the DORM or the CAM? Students in Regular Chemistry 1 (N = 23), Honors Chemistry 1 (N = 51) and Chemistry 2 (N = 15) at an urban high school were the study participants. An identical pretest and posttest was given before and after instruction. Students were given instruction with either the DORM (N = 45), the treatment method, or the CAM (N = 44), the control for two days. After the posttest, 15 students were interviewed, using a semistructured interview process. The pretest/posttest consisted of 23 numerical response questions and 2 to 6 free response questions that were graded using a rubric. A two-way ANOVA showed a significant interaction effect between the groups and the methods, F (1, 70) = 10.960, p = 0.001. Post hoc comparisons using the Bonferroni pairwise comparison showed that Reg Chem 1 students demonstrated larger gain scores when they had been taught the CAM (Mean difference = 3.275, SE = 1.324, p < 0.05), while Hon Chem 1 students demonstrated larger gain scores after learning the DORM (Mean difference = 1.931, SE = 0.848, p < 0.05). The DORM requires five mathematical operations, while the CAM only requires one. Honors Chemistry 1 students performed better with the DORM, perhaps due to better math skills, enhanced working memory, and better metacognitive skills. Regular Chemistry 1 students performed better with the CAM, perhaps because it is more visual. Teachers may want to use the CAM or a direct-pairing method to introduce the topic and use the DORM in advanced classes when a correct structure is needed

  9. Cascade dearomatization of N-substituted tryptophols via Lewis acid-catalyzed Michael reactions.

    PubMed

    Liu, Chuan; Zhang, Wei; Dai, Li-Xin; You, Shu-Li

    2012-09-21

    Lewis acid-catalyzed cascade dearomatization of N-substituted tryptophols via Michael addition reaction was developed. The generality of the method has been demonstrated by the synthesis of versatile furoindoline derivatives with a quaternary carbon center in good yields.

  10. Organo-Lewis acid as cocatalyst for cationic homogenous metallocene Ziegler-Natta olefin polymerizations

    DOEpatents

    Marks, Tobin J.; Chen, You-Xian

    2000-01-01

    The synthesis of the organo-Lewis acid perfluorobiphenylborane (PBB) and the activation of metallocenes for the formation of a variety of highly active homogeneous Ziegler-Natta metallocene olefin polymerization, copolymerization and ring-opening polymerization catalysts is described.

  11. Highlighting High Performance: Adam Joseph Lewis Center for Environmental Studies, Oberlin College, Oberlin, Ohio

    SciTech Connect

    2002-11-01

    Oberlin College’s Adam Joseph Lewis Center for Environmental Studies is a high-performance building featuring an expansive photovoltaic system and a closed-loop groundwater heat pump system. Designers incorporated energy-efficient components and materials

  12. Sialyl Lewis(x)/E-selectin-mediated rolling in a cell-free system.

    PubMed Central

    Brunk, D K; Goetz, D J; Hammer, D A

    1996-01-01

    Selections mediate transient adhesion of neutrophils to stimulated endothelial cells at sites of inflammation by binding counter-receptors that present carbohydrates such as sialyl Lewis(x). We have developed a cell-free adhesion assay using sialyl Lewis(x)-coated microspheres and E-selection-IgG chimera-coated substrates to investigate the premise that rolling primarily results from functional properties of selection-carbohydrate bonds, whereas cellular morphology and signaling act as secondary effects. Sialyl Lewis(x)-coated microspheres attach to and roll over E-selectin-IgG chimera-coated substrates between the physiological wall shear stresses of 0.7 and 2 dynes/cm2. Rolling velocities vary with time and depend on E-selectin-IgG chimera site density and wall shear stress. Our results show that sialyl Lewis(x) is a minimal functional recognition element required for rolling on E-selectin under flow. Images FIGURE 2 PMID:8913627

  13. Redox and Lewis acid-base activities through an electronegativity-hardness landscape diagram.

    PubMed

    Das, Ranjita; Vigneresse, Jean-Louis; Chattaraj, Pratim Kumar

    2013-11-01

    Chemistry is the science of bond making and bond breaking which requires redistribution of electron density among the reactant partners. Accordingly acid-base and redox reactions form cardinal components in all branches of chemistry, e.g., inorganic, organic, physical or biochemistry. That is the reason it forms an integral part of the undergraduate curriculum all throughout the globe. In an electronegativity (χ)- hardness (η) landscape diagram the diagonal χ = η line separates reducing agents from oxidizing agents as well as Lewis acids from Lewis bases. While electronegativity is related to the degree of electron transfer between two reactants, hardness is related to the resistance to that process. Accordingly the electronegativities of oxidizing agents/Lewis acids are generally greater than the corresponding hardness values and the reverse is true for reducing agents/Lewis bases. Electrophiles and nucleophiles are also expected to follow similar trends.

  14. Facile synthesis of planar chiral N-oxides and their use in Lewis base catalysis.

    PubMed

    Fulton, J Robin; Glover, Jean E; Kamara, Lamin; Rowlands, Gareth J

    2011-01-07

    A rapid and versatile method for the preparation of planar chiral [2.2]paracyclophane-derived pyridines and pyridine N-oxides is reported. The potential utility of these compounds in Lewis base catalysis is briefly introduced.

  15. C{sub 2}-symmetric Copper(II) complexes as chiral Lewis acids

    SciTech Connect

    Evans, D.A.; Murry, J.A.; Matt, P. von

    1995-12-01

    Two new Cu(II)-derived Lewis acid catalysts 1 and 2 have been prepared and their utility as catalysts in the Diels-Alder reaction documented. While complex 1 is effective in catalyzing the cycloaddition of unsaturated aldehyde dienophiles with cyclopentadiene complex 2 is optimal for imide dienophiles. This study provides a rational basis for the design of Lewis acids based on the coordinating capacity of cationic Cu(II) complexes which possess sufficient Lewis acidity to catalyze a range of synthetically useful Diels-Alder reactions. In particular, documentation of the importance of counterion structure in the use of cationic metal centers as Lewis acids has been made for the first time.

  16. [Book review] The youngest science: notes of a medicine-watcher, by Lewis Thomas

    USGS Publications Warehouse

    Johnson, D.H.

    1984-01-01

    Review of: The youngest science: notes of a medicine-watcher. Alfred P. Sloan Foundation Series. Lewis Thomas. Penguin Books, 1995. Pennsylvania State University. 270 pp. ISBN: 0140243275, 9780140243277.

  17. Lewis Research Center studies of multiple large wind turbine generators on a utility network

    NASA Technical Reports Server (NTRS)

    Gilbert, L. J.; Triezenberg, D. M.

    1979-01-01

    A NASA-Lewis program to study the anticipated performance of a wind turbine generator farm on an electric utility network is surveyed. The paper describes the approach of the Lewis Wind Energy Project Office to developing analysis capabilities in the area of wind turbine generator-utility network computer simulations. Attention is given to areas such as, the Lewis Purdue hybrid simulation, an independent stability study, DOE multiunit plant study, and the WEST simulator. Also covered are the Lewis mod-2 simulation including analog simulation of a two wind turbine system and comparison with Boeing simulation results, and gust response of a two machine model. Finally future work to be done is noted and it is concluded that the study shows little interaction between the generators and between the generators and the bus.

  18. A bidentate Lewis acid with a telluronium ion as an anion-binding site

    NASA Astrophysics Data System (ADS)

    Zhao, Haiyan; Gabbaï, François P.

    2010-11-01

    The search for receptors that can selectively capture small and potentially toxic anions in protic media has sparked a renewed interest in the synthesis and anion-binding properties of polydentate Lewis acids. Seeking new paradigms to enhance the anion affinities of such systems, we synthesized a bidentate Lewis acid that contains a boryl and a telluronium moiety as Lewis acidic sites. Anion-complexation studies indicate that this telluronium borane displays a high affinity for fluoride in methanol. Structural and computational studies show that the unusual fluoride affinity of this bidentate telluronium borane can be correlated with the formation of a B-F --> Te chelate motif supported by a strong lone-pair(F) --> σ*(Te-C) donor-acceptor interaction. These results, which illustrate the viability of heavier chalcogenium centres as anion-binding sites, allow us to introduce a novel strategy for the design of polydentate Lewis acids with enhanced anion affinities.

  19. A bidentate Lewis acid with a telluronium ion as an anion-binding site.

    PubMed

    Zhao, Haiyan; Gabbaï, François P

    2010-11-01

    The search for receptors that can selectively capture small and potentially toxic anions in protic media has sparked a renewed interest in the synthesis and anion-binding properties of polydentate Lewis acids. Seeking new paradigms to enhance the anion affinities of such systems, we synthesized a bidentate Lewis acid that contains a boryl and a telluronium moiety as Lewis acidic sites. Anion-complexation studies indicate that this telluronium borane displays a high affinity for fluoride in methanol. Structural and computational studies show that the unusual fluoride affinity of this bidentate telluronium borane can be correlated with the formation of a B-F → Te chelate motif supported by a strong lone-pair(F) → σ*(Te-C) donor-acceptor interaction. These results, which illustrate the viability of heavier chalcogenium centres as anion-binding sites, allow us to introduce a novel strategy for the design of polydentate Lewis acids with enhanced anion affinities.

  20. Summary of the NASA Lewis component technology program for Stirling power converters

    NASA Technical Reports Server (NTRS)

    Thieme, Lanny G.; Swec, Diane M.

    1992-01-01

    An update is presented on the NASA Lewis Stirling component technology program. The component technology program has been organized as part of the NASA Lewis effort to develop Stirling converter technology for space power applications. The Stirling space power project is part of the High Capacity Power element of the NASA Civil Space Technology Initiative (CSTI). Lewis is also providing technical management of a DOE funded project to develop Stirling converter systems for distributed dish solar terrestrial power applications. The primary contractors for the space power and solar terrestrial projects develop component technologies directly related to their project goals. This Lewis component technology program, while coordinated with these main projects, is aimed at longer term issues, advanced technologies, and independent assessments. Topics to be discussed include bearings, linear alternators, controls and load interaction, materials/life assessment, and heat exchangers.

  1. Synergistic effects between Lewis and Brønsted acids: application to the Prins cyclization.

    PubMed

    Breugst, Martin; Grée, René; Houk, K N

    2013-10-04

    Brønsted and Lewis acids can catalyze the Prins cyclization, an efficient method for the synthesis of tetrahydropyrans from homoallylic alcohols and carbonyl compounds. Synergistic effects between weak Brønsted and Lewis acids in these reactions have been analyzed by density functional theory [M06-L/def2-QZVP/IEFPCM(CH2Cl2)//M06-L/6-311+G(2df,2p)]. In order to characterize the reactivities of the employed Lewis acids, methyl anion and hydroxide affinities were determined. On the basis of our calculations, we found that the coordination of Lewis acids to carboxylic and sulfonic acids results in a significant increase in the Brønsted acidities of the latter.

  2. Plans and status of the NASA-Lewis Research Center wind energy project

    NASA Technical Reports Server (NTRS)

    Thomas, R.; Puthoff, R.; Savino, J.; Johnson, W.

    1975-01-01

    Wind energy is investigated as a source of energy. The wind energy program that is managed by the NASA-Lewis Research Center is described. The Lewis Research Center's Wind Power Office, its organization, plans, and status are discussed. Major elements of the wind power project included are: an experimental 100 kW wind-turbine generator; first generation industry-built and user-operated wind turbine generators; and supporting research and technology tasks.

  3. An Engineering Approach to Management of Occupational and Community Noise Exposure at NASA Lewis Research Center

    NASA Technical Reports Server (NTRS)

    Cooper, Beth A.

    1997-01-01

    Workplace and environmental noise issues at NASA Lewis Research Center are effectively managed via a three-part program that addresses hearing conservation, community noise control, and noise control engineering. The Lewis Research Center Noise Exposure Management Program seeks to limit employee noise exposure and maintain community acceptance for critical research while actively pursuing engineered controls for noise generated by more than 100 separate research facilities and the associated services required for their operation.

  4. Lactadherin is a candidate oviduct Lewis X trisaccharide receptor on porcine spermatozoa.

    PubMed

    Silva, E; Frost, D; Li, L; Bovin, N; Miller, D J

    2017-03-15

    A recent study has demonstrated that porcine spermatozoa recognize with high affinity carbohydrate structures containing Lewis X motifs. Sperm adhesion to Lewis X is proposed to mediate sperm binding to the oviduct epithelium to form a reservoir. The objective of this study was to identify Lewis X-binding proteins from porcine spermatozoa as candidate receptors for oviduct glycans. To identify low-abundance proteins typically masked by proteins originating from seminal fluid, Lewis X candidate receptors were enriched from cauda epididymal boar spermatozoa. Plasma membrane preparations from cauda epididymal spermatozoa were subjected to RP-HPLC and glycan blotting assays to isolate and detect proteins that bind Lewis X. Following bottom-up LC-MS/MS analysis, among the two bands that bound sulfated Lewis X, ADAM5, which spermatozoa, was confidently identified. ADAM family members have been established as contributors to sperm entry into the oviduct. A second sulfated Lewis X-binding protein identified was the peripheral membrane protein lactadherin (also known as P47, SED1 and MFG-E8 in different species). The interaction between Lewis X and lactadherin was functionally important because competitive inhibition by soluble recombinant lactadherin reduced sperm binding to the oviduct epithelium. Furthermore, far-western blotting demonstrated that purified lactadherin could bind oviduct cells. In summary, these findings reveal that, in addition to the previously reported glycan affinity of accessory gland proteins that adhere to spermatozoa, multiple proteins intrinsic to spermatozoa have affinity for a specific oviduct glycan. Further, in addition to binding to the zona pellucida, lactadherin is now implicated in binding to oviduct glycans to promote formation of the sperm reservoir.

  5. Prospective study of relations between cortical Lewy bodies, poor eyesight, and hallucinations in Alzheimer's disease.

    PubMed

    McShane, R; Gedling, K; Reading, M; McDonald, B; Esiri, M M; Hope, T

    1995-08-01

    The presence of hallucinations is included in some, but not all, of the sets of clinical diagnostic criteria that have been proposed for dementia associated with cortical Lewy bodies. These criteria were developed from retrospective casenote analyses. This prospective, longitudinal study suggests that, in patients with Alzheimer's disease, cortical Lewy bodies are associated with more persistent and severe hallucinations, independently of any association with severity of cognitive decline. Poor eyesight contributes to the severity but not the persistence of the hallucinations.

  6. A dual Lewis base activation strategy for enantioselective carbene-catalyzed annulations.

    PubMed

    Izquierdo, Javier; Orue, Ane; Scheidt, Karl A

    2013-07-24

    A dual activation strategy integrating N-heterocyclic carbene (NHC) catalysis and a second Lewis base has been developed. NHC-bound homoenolate equivalents derived from α,β-unsaturated aldehydes combine with transient reactive o-quinone methides in an enantioselective formal [4 + 3] fashion to access 2-benzoxopinones. The overall approach provides a general blueprint for the integration of carbene catalysis with additional Lewis base activation modes.

  7. Thioarsenides: A case for long-range Lewis acid-base-directed van der Waals interactions

    SciTech Connect

    Gibbs, Gerald V.; Wallace, Adam F.; Downs, R. T.; Ross, Nancy L.; Cox, David F.; Rosso, Kevin M.

    2011-04-01

    Electron density distributions, bond paths, Laplacian and local energy density properties have been calculated for a number of As4Sn (n = 3,4,5) thioarsenide molecular crystals. On the basis of the distributions, the intramolecular As-S and As-As interactions classify as shared bonded interactions and the intermolecular As-S, As-As and S-S interactions classify as closed-shell van der Waals bonded interactions. The bulk of the intermolecular As-S bond paths link regions of locally concentrated electron density (Lewis base regions) with aligned regions of locally depleted electron density (Lewis acid regions) on adjacent molecules. The paths are comparable with intermolecular paths reported for several other molecular crystals that link aligned Lewis base and acid regions in a key-lock fashion, interactions that classified as long range Lewis acid-base directed van der Waals interactions. As the bulk of the intermolecular As-S bond paths (~70%) link Lewis acid-base regions on adjacent molecules, it appears that molecules adopt an arrangement that maximizes the number of As-S Lewis acid-base intermolecular bonded interactions. The maximization of the number of Lewis acid-base interactions appears to be connected with the close-packed array adopted by molecules: distorted cubic close-packed arrays are adopted for alacránite, pararealgar, uzonite, realgar and β-AsS and the distorted hexagonal close-packed arrays adopted by α- and β-dimorphite. A growth mechanism is proposed for thioarsenide molecular crystals from aqueous species that maximizes the number of long range Lewis acid-base vdW As-S bonded interactions with the resulting directed bond paths structuralizing the molecules as a molecular crystal.

  8. Bifunctional ruthenium(II) hydride complexes with pendant strong Lewis acid moieties: structure, dynamics, and cooperativity.

    PubMed

    Ostapowicz, Thomas G; Merkens, Carina; Hölscher, Markus; Klankermayer, Jürgen; Leitner, Walter

    2013-02-13

    The synthesis of a novel class of bifunctional ruthenium hydride complexes incorporating Lewis acidic BR(2) moieties is reported. Determination of the molecular structures in the solid state and in solution provided evidence for tunable interaction between the two functionalities. Cooperative effects on the reactivity of the complexes were demonstrated including the activation of small Lewis basic molecules by reversible anchoring at the boron center.

  9. Synthesis and Lewis acid properties of a ferrocene-based planar-chiral borenium cation.

    PubMed

    Chen, Jiawei; Lalancette, Roger A; Jäkle, Frieder

    2013-05-28

    The first planar chiral ferrocenylborenium species (pR)-3(+) is obtained in the enantiopure form by halide abstraction from the corresponding chloroborane adduct (pR)-2 using Krossing's salt. Competition experiments suggest that the Lewis acidity of (pR)-3(+) is higher than that of B(C6F5)3 towards anions and slightly lower towards neutral Lewis bases. The ferrocenylborenium species (pR)-3(+) is examined as a catalyst for the stereoselective hydrosilylation of ketones.

  10. Shell shock at Queen Square: Lewis Yealland 100 years on

    PubMed Central

    Jones, Edgar; Lees, Andrew J.

    2013-01-01

    This article reviews the treatment of functional neurological symptoms during World War I by Lewis Yealland at the National Hospital for the Paralysed and Epileptic in London. Yealland was among the first doctors in Britain to incorporate electricity in the systematic treatment of shell shock. Our analysis is based on the original case records of his treatment of 196 soldiers with functional motor and sensory symptoms, functional seizures and somatoform disorders. Yealland’s treatment approach integrated peripheral and central electrical stimulation with a variety of other—psychological and physical—interventions. A combination of electrical stimulation of affected muscles with suggestion of imminent improvement was the hallmark of his approach. Although his reported success rates were high, Yealland conducted no formal follow-up. Many of the principles of his treatment, including the emphasis on suggestion, demonstration of preserved function and the communication of a physiological illness model, are encountered in current therapeutic approaches to functional motor and sensory symptoms. Yealland has been attacked for his use of electrical stimulation and harsh disciplinary procedures in popular and scientific literature during and after World War I. This criticism reflects changing views on patient autonomy and the social role of doctors and directly impacts on current debates on ethical justification of suggestive therapies. We argue that knowledge of the historical approaches to diagnosis and management of functional neurological syndromes can inform both aetiological models and treatment concepts for these challenging conditions. PMID:23384604

  11. Frustrated Lewis Pair Chemistry: Searching for New Reactions.

    PubMed

    Kehr, Gerald; Erker, Gerhard

    2017-04-12

    Frustrated Lewis pair chemistry has taken a steep development in the recent years. It offers possibilities of developing new variants of known reactions and of finding new chemical transformations. This is demonstrated and described by the recently developed FLP-formylborane chemistry, which has led to the formation of the unique (η(2) -formylborane)FLP adducts and opened a way of preparing a genuine formylborane compound, which shows an interesting follow-up chemistry. FLPs have helped finding phosphorus analogues of the enamine Stork reaction and the Claisen reaction. These reactions lead to new organophosphorus compounds and they make new phosphane/borane systems available. P/B FLPs add to a variety of small main group element oxides. They undergo 1,2-addition reactions to CO2 , SO2 and other heterocumulenes and they feature unique 1,1-addition reactions to carbon monoxide, to isonitriles and even to nitric oxide (NO), the latter yielding examples of a new class of persistent nitroxide radicals, the FLPNO nitroxyls. Eventually, some remarkable radical reactions of FLPs and related compounds are briefly mentioned.

  12. Cyclic Oxidation Testing and Modelling: A NASA Lewis Perspective

    NASA Technical Reports Server (NTRS)

    Smialek, J. L.; Nesbitt, J. A.; Barrett, C. A.; Lowell, C. E.

    2000-01-01

    The Materials Division of the NASA Lewis Research Center has been heavily involved in the cyclic oxidation of high temperature materials for 30 years. Cyclic furnace and burner rig apparati have been developed, refined, and replicated to provide a large scale facility capable of evaluating many materials by a standard technique. Material behavior is characterized by weight change data obtained throughout the test, which has been modelled in a step-wise process of scale growth and spallation. This model and a coupled diffusion model have successfully described cyclic behavior for a number of systems and have provided insights regarding life prediction and variations in the spalling process. Performance ranking and mechanistic studies are discussed primarily for superalloys and coating alloys. Similar cyclic oxidation studies have been performed on steels, intermetallic compounds, thermal barrier coatings, ceramics, and ceramic composites. The most common oxidation test was performed in air at temperatures ranging from 800 deg. to 1600 C, for times up to 10000 h, and for cycle durations of 0.1 to 1000 h. Less controlled, but important, test parameters are the cooling temperature and humidity level. Heating and cooling rates are not likely to affect scale spallation. Broad experience has usually allowed for considerable focus and simplification of these test parameters, while still revealing the principal aspects of material behavior and performance. Extensive testing has been performed to statistically model the compositional effects of experimental alloys and to construct a comprehensive database of complex commercial alloys.

  13. LSENS, The NASA Lewis Kinetics and Sensitivity Analysis Code

    NASA Technical Reports Server (NTRS)

    Radhakrishnan, K.

    2000-01-01

    A general chemical kinetics and sensitivity analysis code for complex, homogeneous, gas-phase reactions is described. The main features of the code, LSENS (the NASA Lewis kinetics and sensitivity analysis code), are its flexibility, efficiency and convenience in treating many different chemical reaction models. The models include: static system; steady, one-dimensional, inviscid flow; incident-shock initiated reaction in a shock tube; and a perfectly stirred reactor. In addition, equilibrium computations can be performed for several assigned states. An implicit numerical integration method (LSODE, the Livermore Solver for Ordinary Differential Equations), which works efficiently for the extremes of very fast and very slow reactions, is used to solve the "stiff" ordinary differential equation systems that arise in chemical kinetics. For static reactions, the code uses the decoupled direct method to calculate sensitivity coefficients of the dependent variables and their temporal derivatives with respect to the initial values of dependent variables and/or the rate coefficient parameters. Solution methods for the equilibrium and post-shock conditions and for perfectly stirred reactor problems are either adapted from or based on the procedures built into the NASA code CEA (Chemical Equilibrium and Applications).

  14. Cyclosporin a. Inhibition of experimental autoimmune uveitis in Lewis rats.

    PubMed Central

    Nussenblatt, R B; Rodrigues, M M; Wacker, W B; Cevario, S J; Salinas-Carmona, M C; Gery, I

    1981-01-01

    Cyclosporin A (CS-A), a selective inhibitor of T lymphocytes, is reported here to prevent S antigen (S-Ag) induced uveitis in Lewis rats. The S-Ag, found in all mammalian retinas, is uveitogenic under experimental conditions and patients with certain uveitic entities demonstrate cell mediated responses to this antigen. Daily treatment with CS-A (10 mg/kg) begun on the same day as S-Ag immunization totally inhibited the development of the uveitis in this experimental autoimmune model. Moreover a greater CS-A dose (40 mg/kg) efficiently prevented the disease process when therapy was started 7 d after S-Ag immunization. Anti-S-Ag antibody titers were observed to be similar in rats either protected or not protected with CS-A. Our data support strongly the need for T cell participation in this disease model. Since ocular inflammatory disease is an important cause of visual impairment, the data further suggest that CS-A may be useful in the treatment of patients with intractable uveitis. Images PMID:7204576

  15. Lewis-Riesenfeld invariants and transitionless quantum driving

    SciTech Connect

    Chen Xi; Torrontegui, E.; Muga, J. G.

    2011-06-15

    Different methods have been recently put forward and implemented experimentally to inverse engineer the time-dependent Hamiltonian of a quantum system and accelerate slow adiabatic processes via nonadiabatic shortcuts. In the ''transitionless quantum driving'' proposed by Berry, shortcut Hamiltonians are designed so that the system follows exactly, in an arbitrarily short time, the approximate adiabatic path defined by a reference Hamiltonian. A different approach is based on first designing a Lewis-Riesenfeld invariant to carry the eigenstates of a Hamiltonian from specified initial to final configurations, again in an arbitrary time, and then constructing from the invariant the transient Hamiltonian that connects these boundary configurations. We show that the two approaches, apparently quite different in form and so far in results, are, in fact, strongly related and potentially equivalent, so that the inverse-engineering operations in one of them can be reinterpreted and understood in terms of the concepts and operations of the other one. We study, as explicit examples, expansions of time-dependent harmonic traps and the state preparation of two-level systems.

  16. Activities of the Structures Division, Lewis Research Center

    NASA Technical Reports Server (NTRS)

    1990-01-01

    The purpose of the NASA Lewis Research Center, Structures Division's 1990 Annual Report is to give a brief, but comprehensive, review of the technical accomplishments of the Division during the past calendar year. The report is organized topically to match the Center's Strategic Plan. Over the years, the Structures Division has developed the technology base necessary for improving the future of aeronautical and space propulsion systems. In the future, propulsion systems will need to be lighter, to operate at higher temperatures and to be more reliable in order to achieve higher performance. Achieving these goals is complex and challenging. Our approach has been to work cooperatively with both industry and universities to develop the technology necessary for state-of-the-art advancement in aeronautical and space propulsion systems. The Structures Division consists of four branches: Structural Mechanics, Fatigue and Fracture, Structural Dynamics, and Structural Integrity. This publication describes the work of the four branches by three topic areas of Research: (1) Basic Discipline; (2) Aeropropulsion; and (3) Space Propulsion. Each topic area is further divided into the following: (1) Materials; (2) Structural Mechanics; (3) Life Prediction; (4) Instruments, Controls, and Testing Techniques; and (5) Mechanisms. The publication covers 78 separate topics with a bibliography containing 159 citations. We hope you will find the publication interesting as well as useful.

  17. Clinical and neuroimaging characteristics of Chinese dementia with Lewy bodies

    PubMed Central

    Wang, Ying; Shi, Zhihong; Cai, Li; Liu, Shuling; Han, Tong; Zhou, Yuying; Wang, Xinping; Gao, Shuo; Ji, Yong

    2017-01-01

    Dementia with Lewy bodies (DLB) is the second most common subtype of degenerative dementia. To our knowledge, available information about the clinical features of DLB in China remains limited. Our study therefore aimed to address this issue. Thirty-seven Chinese patients with probable DLB were recruited for this study. All subjects underwent neuropsychological assessment by trained neurologists, as well as undergoing MRI, 11C-PIB PET scans for Aβ deposition and 18F-FDG PET scans for regional cerebral glucose metabolism. Our results showed that the gender ratio of patients was 16:21 (F:M). The mean age of onset was 69.5 ± 9.0 years and the mean age at diagnosis was 71.8 ± 9.1 years. At diagnosis, the prevalence of three core clinical features of DLB was: 64.9% for fluctuating cognition, 73.0% for visual hallucinations and 62.2% for parkinsonism. The result from 11C-PiB PET and 18F-FDG PET scans confirmed Aβ deposition in the cortex and demonstrated hypometabolism in the bilateral temporoparietooccipital region, the frontal lobe, the insular lobe, and the posterior cingulate, precuneus and caudate nuclei. Our study elucidated the clinical features of Chinese DLB patients, and will improve the understanding and the early diagnosis of DLB in Chinese patients. PMID:28253276

  18. Biomarkers of Parkinson's disease and Dementia with Lewy bodies.

    PubMed

    Henchcliffe, Claire; Dodel, Richard; Beal, M Flint

    2011-12-01

    Parkinson's disease (PD) and Dementia with Lewy bodies (DLB) are progressive and disabling neurodegenerative disorders, in which signs and symptoms overlap with each other and with other neurodegenerative conditions. Currently, diagnosis, measurement of progression, and response to therapeutic intervention rely upon clinical observation. However, there remains a critical need for validated biomarkers in each of these areas. A definitive diagnostic test would improve clinical management and enrollment into clinical trials. An objective measure of progression is vitally important in identifying neuroprotective interventions. Biomarkers may also provide insight into pathogenesis, and might therefore suggest possible novel targets for therapeutic intervention. In addition, certain biomarkers might be of use in monitoring the biochemical and physiological effects of therapeutic interventions. Development of diagnostic biomarkers has focused until recently upon imaging techniques based upon measuring loss of dopamine neurons. Additionally, advances in understanding the genetic contribution to neurodegenerative disorders, in particular in PD, have identified multiple causative genes and risk factors that in some cases may help estimate PD risk. However, recent availability of increasingly sophisticated bioinformatics technology has rendered development of fluid biomarkers feasible, opening the possibility of generally accessible blood or cerebrospinal fluid (CSF) tests that could impact upon diagnosis, management, and research in PD, PDD, and DLB.

  19. NASA Lewis Research Center's Preheated Combustor and Materials Test Facility

    NASA Technical Reports Server (NTRS)

    Nemets, Steve A.; Ehlers, Robert C.; Parrott, Edith

    1995-01-01

    The Preheated Combustor and Materials Test Facility (PCMTF) in the Engine Research Building (ERB) at the NASA Lewis Research Center is one of two unique combustor facilities that provide a nonvitiated air supply to two test stands, where the air can be used for research combustor testing and high-temperature materials testing. Stand A is used as a research combustor stand, whereas stand B is used for cyclic and survivability tests of aerospace materials at high temperatures. Both stands can accommodate in-house and private industry research programs. The PCMTF is capable of providing up to 30 lb/s (pps) of nonvitiated, 450 psig combustion air at temperatures ranging from 850 to 1150 g F. A 5000 gal tank located outdoors adjacent to the test facility can provide jet fuel at a pressure of 900 psig and a flow rate of 11 gal/min (gpm). Gaseous hydrogen from a 70,000 cu ft (CF) tuber is also available as a fuel. Approximately 500 gpm of cooling water cools the research hardware and exhaust gases. Such cooling is necessary because the air stream reaches temperatures as high as 3000 deg F. The PCMTF provides industry and Government with a facility for studying the combustion process and for obtaining valuable test information on advanced materials. This report describes the facility's support systems and unique capabilities.

  20. NASA Lewis steady-state heat pipe code users manual

    NASA Technical Reports Server (NTRS)

    Tower, Leonard K.; Baker, Karl W.; Marks, Timothy S.

    1992-01-01

    The NASA Lewis heat pipe code was developed to predict the performance of heat pipes in the steady state. The code can be used as a design tool on a personal computer or with a suitable calling routine, as a subroutine for a mainframe radiator code. A variety of wick structures, including a user input option, can be used. Heat pipes with multiple evaporators, condensers, and adiabatic sections in series and with wick structures that differ among sections can be modeled. Several working fluids can be chosen, including potassium, sodium, and lithium, for which monomer-dimer equilibrium is considered. The code incorporates a vapor flow algorithm that treats compressibility and axially varying heat input. This code facilitates the determination of heat pipe operating temperatures and heat pipe limits that may be encountered at the specified heat input and environment temperature. Data are input to the computer through a user-interactive input subroutine. Output, such as liquid and vapor pressures and temperatures, is printed at equally spaced axial positions along the pipe as determined by the user.

  1. Naphthylaminoborane: from structural switches to frustrated Lewis pair reactivity.

    PubMed

    Pla, Daniel; Sadek, Omar; Cadet, Sarah; Mestre-Voegtlé, Béatrice; Gras, Emmanuel

    2015-11-14

    A series of naphthyl-bridged amino-borane derivatives, namely 1-(dimethylamino)-8-naphthylboranes (1, 3, 5, 7) and 5-(dimethylamino)-6-acenaphthylboranes (2, 4, 6, 8, 10, 11), differing in the steric and electronic properties of the boryl moiety, have been synthesized and fully characterized by spectroscopic and crystallographic means. Structural X-ray analysis of the peri-atom displacement and ring torsion angles served to experimentally assess the presence and magnitude of the B-N interactions. The reversible quaternarization of nitrogen has been explored and was found to provide an efficient switch corresponding to different molecular organizations. The electronic characteristics of the nature of B-N interactions were further studied by Natural Bonding Orbital analysis derived from the theoretically calculated electron densities. This real-space bonding indicator discriminates the bonding B-N contact in 5 from the nonbonding in 8, which correlates with the flexibility of the naphthyl scaffold to respond to the Lewis acidity of boron allowing shorter peri interactions. Whereas, the steric shielding imposed by the two mesityl groups, and/or the rigidity of the acenaphthene framework disrupt B-N interaction. Thus, this communication reports on the modulation of the B-N bonding continuum by means of structural tuning leading to a molecular switch, as well as its implications towards revealing FLP reactivities through the isolation of intermediates of a stepwise mechanism.

  2. Lewis-Sumner syndrome and multifocal motor neuropathy.

    PubMed

    Verschueren, Annie; Azulay, Jean Philippe; Attarian, Shahram; Boucraut, José; Pellissier, Jean François; Pouget, Jean

    2005-01-01

    We compared the clinical, electrophysiological, laboratory, and pathological features of 13 patients with Lewis-Sumner syndrome (LSS) with those of 20 patients with multifocal motor neuropathy (MMN). LSS and MMN patients have several common clinical features: age at onset, weakness in the distribution of individual peripheral nerves, mild wasting, cramps and fasciculations, partial areflexia, and frequent stepwise disease course. Cerebrospinal fluid protein level was normal or slightly elevated, but always less than 100 mg/dl. Conduction blocks are the electrophysiological hallmarks of these two neuropathies, and no differences in distribution and number of blocks were found. Contrary to MMN, lower-limb involvement at onset was frequent in LSS but extension to the upper limbs was a frequent later feature of the disease. Cranial nerve involvement was noted in 4 LSS patients during relapses and absent in all MMN patients. The major distinguishing features were the clinical and electrophysiological sensory involvement in LSS, and the lack of anti-GM1 antibodies in LSS, whereas IgM anti-GM1 were found in 40% of MMN patients. Some LSS patients responded to steroid therapy, whereas this was ineffective in MMN. From these features, LSS can be considered an entity distinct from MMN, with its own clinical, laboratory, and electrophysiological characteristics, and as an intermediate link between chronic inflammatory demyelinating polyneuropathy and MMN.

  3. Power System Reliability Assessment by Analysing Voltage Dips on the Blue Horizon Bay 22KV Overhead Line in the Nelson Mandela Bay Municipality

    NASA Astrophysics Data System (ADS)

    Lamour, B. G.; Harris, R. T.; Roberts, A. G.

    2010-06-01

    Power system reliability problems are very difficult to solve because the power systems are complex and geographically widely distributed and influenced by numerous unexpected events. It is therefore imperative to employ the most efficient optimization methods in solving the problems relating to reliability of the power system. This paper presents a reliability analysis and study of the power interruptions resulting from severe power outages in the Nelson Mandela Bay Municipality (NMBM), South Africa and includes an overview of the important factors influencing reliability, and methods to improve the reliability. The Blue Horizon Bay 22 kV overhead line, supplying a 6.6 kV residential sector has been selected. It has been established that 70% of the outages, recorded at the source, originate on this feeder.

  4. Hormonal secretion and quality of life in Nelson syndrome and Cushing disease after long acting repeatable octreotide: a short series and update.

    PubMed

    Arregger, Alejandro L; Cardoso, Estela M L; Sandoval, Olga B; Monardes Tumilasci, Elida G; Sanchez, Rocío; Contreras, Liliana N

    2014-01-01

    Clinical management of persistent adrenocorticotropin hormone (ACTH) excess in Nelson syndrome (NS) and Cushing disease (CD) remains a challenge. Somatostatin and its analogs as octreotide decrease ACTH secretion through somatostatin receptors of pituitary cells. To our knowledge, there are no reports on the effect of long-acting repeatable octreotide (oct-lar) on hormonal secretion and quality of life in patients with NS and CD who failed conventional therapy. Herein, we describe the effects of treatment with oct-lar (20 mg/month intramurally) in 1 woman with NS and 2 women with persistent CD. Oct-lar therapy reduced ACTH secretion and improved the quality of life in NS patient. By contrast, in CD patients, it failed to control ACTH and cortisol secretion, and the quality of life remained unchanged.

  5. Sedimentary Records of Hyperpycnal Flows and the Influence of River Damming on Sediment Dynamics of Estuaries: Examples from the Nelson, Churchill, Moisie and Sainte-Marguerite Rivers (Canada)

    NASA Astrophysics Data System (ADS)

    St-Onge, G.; Duboc, Q.; Boyer-Villemaire, U.; Lajeunesse, P.; Bernatchez, P.

    2015-12-01

    Sediment cores were sampled in the estuary of the Nelson and Churchill Rivers in western Hudson Bay, as well as in the estuary of the Moisie and Sainte-Marguerite Rivers in Gulf of St. Lawrence in order to evaluate the impact of hydroelectric dams on the sedimentary regime of these estuaries. The gravity cores at the mouth of the Nelson River recorded several cm-thick rapidly deposited layers with a reverse to normal grading sequence, indicating the occurrence of hyperpycnal flows generated by major floods during the last few centuries. These hyperpycnal flows were probably caused by ice-jam formation, which can increase both the flow and the sediment concentration following the breaching of such natural dams. Following the construction of hydroelectric dams since the 1960s, the regulation of river discharge prevented the formation of hyperpycnal flows, and hence the deposition of hyperpycnites in the upper part of the cores. In the core sampled in the estuary of the Churchill River, only one hyperpycnite was recorded. This lower frequency may be due to the enclosed estuary of the Churchill River, its weaker discharge and the more distal location of the coring site.In the Gulf of St. Lawrence, grain size measurements allowed the identification of a major flood around AD 1844±4 years in box cores from both the Sainte-Marguerite and Moisie Rivers, whereas a drastic decrease in variations in the median grain size occurred around AD ~1900 in the estuary of the Sainte-Marguerite River, highlighting the offshore impact of the SM1 dam construction in the early 1900s. Furthermore, sedimentological variations in the box cores from both estuaries have been investigated by wavelet analysis and the sharp disappearance of high frequencies around AD 1900 in the estuary of the dammed river (Sainte-Marguerite River), but not in the estuary of the natural river (Moisie River), also provides evidence of the influence of dams on the sedimentary regime of estuaries.

  6. Dissociation between the aversive and pharmacokinetic effects of ethanol in female Fischer and Lewis rats.

    PubMed

    Roma, Peter G; Chen, Scott A; Barr, Christina S; Riley, Anthony L

    2007-08-22

    In humans and laboratory animal models, vulnerability to alcohol abuse is influenced by endogenous factors such as genotype. Using the inbred Fischer and Lewis rat strains, we previously reported stronger conditioned taste aversions (CTA) in male Fischer rats that could not be predicted by genotypic differences in alcohol absorption [Roma PG, Flint WW, Higley JD, Riley AL. Assessment of the aversive and rewarding effects of alcohol in Fischer and Lewis rats. Psychopharmacology (Berl) 2006;189:187-99]. The present study made similar assessments in Fischer and Lewis females via four-trial CTA induced by 1 or 1.5 g/kg intraperitoneal (IP) ethanol (n=10-12/strain/dose) as well as measures of blood alcohol concentrations (BAC) at 15, 60 and 180 min post-injection with 1.5 g/kg IP ethanol or saline (n=7-8/strain/dose). Dose-dependent CTAs were produced, but the strains did not differ from each other in these measures; however, BACs in the Lewis females were significantly higher than Fischer at all three time points. As with males of the Fischer and Lewis genotypes, a dissociation between BACs and the aversive effects of alcohol was observed. These data are the first assessments of these particular phenotypes in Fischer and Lewis females, and when considered with the historical data, suggest a Genotype x Sex interaction in the centrally mediated sensitivity to alcohol's aversive effects.

  7. Rapid eye movement sleep behavior disorder and subtypes in autopsy-confirmed dementia with Lewy bodies.

    PubMed

    Dugger, Brittany N; Boeve, Bradley F; Murray, Melissa E; Parisi, Joseph E; Fujishiro, Hiroshige; Dickson, Dennis W; Ferman, Tanis J

    2012-01-01

    The purpose of this study was to determine whether dementia with Lewy bodies with and without probable rapid eye movement sleep behavior disorder differ clinically or pathologically. Patients with dementia with Lewy bodies (DLB) with probable rapid eye movement sleep behavior sleep disorder (n = 71) were compared with those without it (n = 19) on demographics, clinical variables (core features of dementia with Lewy bodies, dementia duration, rate of cognitive/motor changes), and pathologic indices (Lewy body distribution, neuritic plaque score, Braak neurofibrillary tangle stage). Individuals with probable rapid eye movement sleep behavior disorder were predominantly male (82% vs 47%) and had a shorter duration of dementia (mean, 8 vs 10 years), earlier onset of parkinsonism (mean, 2 vs 5 years), and earlier onset of visual hallucinations (mean, 3 vs 6 years). These patients also had a lower Braak neurofibrillary tangle stage (stage IV vs stage VI) and lower neuritic plaque scores (18% vs 85% frequency), but no difference in Lewy body distribution. When probable rapid eye movement sleep behavior disorder developed early (at or before dementia onset), the onset of parkinsonism and hallucinations was earlier and Braak neurofibrillary tangle stage was lower compared with those who developed the sleep disorder after dementia onset. Women with autopsy-confirmed DLB without a history of dream enactment behavior during sleep had a later onset of hallucinations and parkinsonism and a higher Braak NFT stage. Probable rapid eye movement sleep behavior disorder is associated with distinct clinical and pathologic characteristics of dementia with Lewy bodies.

  8. Current wind tunnel capability and planned improvements at Lewis Research Center

    NASA Technical Reports Server (NTRS)

    Bowditch, D. N.

    1986-01-01

    As the propulsion and power generation center of NASA, Lewis has designed its wind tunnels for propulsion research. Therefore, the 8 by 6 Foot Supersonic Wind Tunnel and the 10 by 10 Foot Supersonic Wind Tunnel provide the capability to test operating propulsion systems from Mach 0.4 to 3.5. The 9 by 15 Foot Wind Tunnel can investigate propulsion installation problems at the lower takeoff and landing speeds and provides an excellent anechoic environment to measure propeller and fan noise. The Lewis Central Air System provides steady air supplies to 450 psi, and exhaust to 3 in. of mercury absolute, which are available to the wind tunnels for simulation of jets and engine induced flows. The Lewis Icing Research Tunnel is the largest in the free world that can produce icing conditions throughout the year. Rehabilitation of the Altitude Wind Tunnel at Lewis would allow testing of propulsion systems in the upper left hand corner which would be a unique capability. Also, in a mothballed state at Lewis, the Hypersonic Tunnel Facility could provide the best simulation of nonvitiated Mach 5-7 test conditions available. Studies are currently being made of the Lewis facilities to identify enhancements of their research potential for the 1990's and beyond.

  9. Main Group Lewis Acid-Mediated Transformations of Transition-Metal Hydride Complexes.

    PubMed

    Maity, Ayan; Teets, Thomas S

    2016-08-10

    This Review highlights stoichiometric reactions and elementary steps of catalytic reactions involving cooperative participation of transition-metal hydrides and main group Lewis acids. Included are reactions where the transition-metal hydride acts as a reactant as well as transformations that form the metal hydride as a product. This Review is divided by reaction type, illustrating the diverse roles that Lewis acids can play in mediating transformations involving transition-metal hydrides as either reactants or products. We begin with a discussion of reactions where metal hydrides form direct adducts with Lewis acids, elaborating the structure and dynamics of the products of these reactions. The bulk of this Review focuses on reactions where the transition metal and Lewis acid act in cooperation, and includes sections on carbonyl reduction, H2 activation, and hydride elimination reactions, all of which can be promoted by Lewis acids. Also included is a section on Lewis acid-base secondary coordination sphere interactions, which can influence the reactivity of hydrides. Work from the past 50 years is included, but the majority of this Review focuses on research from the past decade, with the intent of showcasing the rapid emergence of this field and the potential for further development into the future.

  10. Helicobacter pylori Does Not Require Lewis X or Lewis Y Expression To Colonize C3H/HeJ mice

    PubMed Central

    Takata, Tohru; El-Omar, Emad; Camorlinga, Margarita; Thompson, Stuart A.; Minohara, Yutaka; Ernst, Peter B.; Blaser, Martin J.

    2002-01-01

    Helicobacter pylori strains frequently express Lewis X (Lex) and/or Ley on their cell surfaces as constituents of the O antigens of their lipopolysaccharide molecules. To assess the effect of Lex and Ley expression on the ability of H. pylori to colonize the mouse stomach and to adhere to epithelial cells, isogenic mutants were created in which fucT1 alone or fucT1 and fucT2, which encode the fucosyl transferases necessary for Lex and Ley expression, were deleted. C3H/HeJ mice were experimentally challenged with either wild-type 26695 H. pylori or its isogenic mutants. All strains, whether passaged in the laboratory or recovered after mouse passage, colonized the mice well and without consistent differences. During colonization by the mutants, there was no reversion to wild type. Similarly, adherence to AGS and KatoIII cells was unaffected by the mutations. Together, these findings indicate that Le expression is not necessary for mouse gastric colonization or for H. pylori adherence to epithelial cells. PMID:12011000

  11. Defining the Recognition Elements of Lewis Y-Reactive Antibodies

    PubMed Central

    Saha, Somdutta; Pashov, Anastas; Siegel, Eric R.; Murali, Ramachandran; Kieber-Emmons, Thomas

    2014-01-01

    Antibody response to carbohydrate antigens is often independent of T cells and the process of affinity/specificity improvement is considered strictly dependent on the germinal centers. Antibodies induced during a T cell-independent type 2 (TI-2) response are less variable and less functionally versatile than those induced with T cell help. The antigen specificity consequences of accumulation of somatic mutations in antibodies during TI-2 responses of Marginal Zone (MZ) B cells is a fact that still needs explanation. Germline genes that define carbohydrate-reactive antibodies are known to sculpt antibody-combining sites containing innate, key side-chain contacts that define the antigen recognition step. However, substitutions associated with MZ B cell derived antibodies might affect the mobility and polyspecificity of the antibody. To examine this hypothesis, we analyzed antibodies reactive with the neolactoseries antigen Lewis Y (LeY) to define the residue subset required for the reactive repertoire for the LeY antigen. Our molecular simulation studies of crystallographically determined and modeled antibody-LeY complexes suggests that the heavy-chain germline gene VH7183.a13.20 and the light-chain Vκ cr1 germline gene are sufficient to account for the recognition of the trisaccharide-H determinant Types 1–4, while the specificity for LeY is driven by the CDR3 backbone conformation of the heavy chain and not the side chain interactions. These results confirm that these monoclonals use germline-encoded amino acids to recognize simple carbohydrate determinants like trisaccharide-H but relies on somatic mutations in the periphery of the combining site to modify affinity for LeY through electrostatic interactions that leads to their optimized binding. These observations bring further attention to the role of mutations in T-cell independent antibodies to distinguish self from non-self carbohydrate antigens. PMID:25117628

  12. Comparative Proteomic Analysis of Two Uveitis Models in Lewis Rats

    PubMed Central

    Pepple, Kathryn L.; Rotkis, Lauren; Wilson, Leslie; Sandt, Angela; Van Gelder, Russell N.

    2015-01-01

    Purpose Inflammation generates changes in the protein constituents of the aqueous humor. Proteins that change in multiple models of uveitis may be good biomarkers of disease or targets for therapeutic intervention. The present study was conducted to identify differentially-expressed proteins in the inflamed aqueous humor. Methods Two models of uveitis were induced in Lewis rats: experimental autoimmune uveitis (EAU) and primed mycobacterial uveitis (PMU). Differential gel electrophoresis was used to compare naïve and inflamed aqueous humor. Differentially-expressed proteins were separated by using 2-D gel electrophoresis and excised for identification with matrix-assisted laser desorption/ionization–time of flight (MALDI-TOF). Expression of select proteins was verified by Western blot analysis in both the aqueous and vitreous. Results The inflamed aqueous from both models demonstrated an increase in total protein concentration when compared to naïve aqueous. Calprotectin, a heterodimer of S100A8 and S100A9, was increased in the aqueous in both PMU and EAU. In the vitreous, S100A8 and S100A9 were preferentially elevated in PMU. Apolipoprotein E was elevated in the aqueous of both uveitis models but was preferentially elevated in EAU. Beta-B2–crystallin levels decreased in the aqueous and vitreous of EAU but not PMU. Conclusions The proinflammatory molecules S100A8 and S100A9 were elevated in both models of uveitis but may play a more significant role in PMU than EAU. The neuroprotective protein β-B2–crystallin was found to decline in EAU. Therapies to modulate these proteins in vivo may be good targets in the treatment of ocular inflammation. PMID:26747776

  13. The NASA Lewis Research Center: An Economic Impact Study

    NASA Technical Reports Server (NTRS)

    Austrian, Ziona

    1996-01-01

    The NASA Lewis Research Center (LeRC), established in 1941, is one of ten NASA research centers in the country. It is situated on 350 acres of land in Cuyahoga County and occupies more than 140 buildings and over 500 specialized research and test facilities. Most of LeRC's facilities are located in the City of Cleveland; some are located within the boundaries of the cities of Fairview Park and Brookpark. LeRC is a lead center for NASA's research, technology, and development in the areas of aeropropulsion and selected space applications. It is a center of excellence for turbomachinery, microgravity fluid and combustion research, and commercial communication. The base research and technology disciplines which serve both aeronautics and space areas include materials and structures, instrumentation and controls, fluid physics, electronics, and computational fluid dynamics. This study investigates LeRC's economic impact on Northeast Ohio's economy. It was conducted by The Urban Center's Economic Development Program in Cleveland State University's Levin College of Urban Affairs. The study measures LeRC's direct impact on the local economy in terms of jobs, output, payroll, and taxes, as well as the indirect impact of these economic activities when they 'ripple' throughout the economy. To fully explain LeRC's overall impact on the region, its contributions in the areas of technology transfer and education are also examined. The study uses a highly credible and widely accepted research methodology. First, regional economic multipliers based on input-output models were used to estimate the effect of LERC spending on the Northeast Ohio economy. Second, the economic models were complemented by interviews with industrial, civic, and university leaders to qualitatively assess LeRC's impact in the areas of technology transfer and education.

  14. Expression of hPNAS-4 Radiosensitizes Lewis Lung Cancer

    SciTech Connect

    Zeng Hui; Yuan Zhu; Zhu Hong; Li Lei; Shi Huashan; Wang Zi; Fan Yu; Deng Qian; Zeng Jianshuang; He Yinbo; Xiao Jianghong; Li Zhiping

    2012-11-15

    Purpose: This study aimed to transfer the hPNAS-4 gene, a novel apoptosis-related human gene, into Lewis lung cancer (LL2) and observe its radiosensitive effect on radiation therapy in vitro and in vivo. Methods and Materials: The hPNAS-4 gene was transfected into LL2 cells, and its expression was detected via western blot. Colony formation assay and flow cytometry were used to detect the growth and apoptosis of cells treated with irradiation/PNAS-4 in vitro. The hPNAS-4 gene was transferred into LL2-bearing mice through tail vein injection of the liposome/gene complex. The tumor volumes were recorded after radiation therapy. Proliferating cell nuclear antigen (PCNA) immunohistochemistry staining and terminal deoxynucleotidyl transferase-mediated dUTP nick end labeling (TUNEL) assay were performed to detect the tumor cell growth and apoptosis in vivo. Results: The hPNAS-4 gene was successfully transferred into LL2 cells and tumor tissue, and its overexpressions were confirmed via western blot analysis. Compared with the control, empty plasmid, hPNAS-4, radiation, and empty plasmid plus radiation groups, the hPNAS-4 plus radiation group more significantly inhibited growth and enhanced apoptosis of LL2 cells in vitro and in vivo (P<.05). Conclusions: The hPNAS-4 gene was successfully transferred into LL2 cells and tumor tissue and was expressed in both LL2 cell and tumor tissue. The hPNAS-4 gene therapy significantly enhanced growth inhibition and apoptosis of LL2 tumor cells by radiation therapy in vitro and in vivo. Therefore, it may be a potential radiosensitive treatment of radiation therapy for lung cancer.

  15. Brain amyloid and cognition in Lewy body diseases.

    PubMed

    Gomperts, Stephen N; Locascio, Joseph J; Marquie, Marta; Santarlasci, Andrea L; Rentz, Dorene M; Maye, Jacqueline; Johnson, Keith A; Growdon, John H

    2012-07-01

    Many patients with PD develop PD with dementia (PDD), a syndrome that overlaps clinically and pathologically with dementia with Lewy bodies (DLB); PDD and DLB differ chiefly in the relative timing of dementia and parkinsonism. Brain amyloid deposition is an early feature of DLB and may account, in part, for its early dementia. We sought to confirm this hypothesis and also to determine whether amyloid accumulation contributes to cognitive impairment and dementia in the broad range of parkinsonian diseases. Twenty-nine cognitively healthy PD, 14 PD subjects with mild cognitive impairment (PD-MCI), 18 with DLB, 12 with PDD, and 85 healthy control subjects (HCS) underwent standardized neurologic and neuropsychological examinations and Pittsburgh compound B (PiB) imaging with PET. Apolipoprotein E (ApoE) genotypes were obtained in many patients. PiB retention was expressed as the distribution volume ratio using a cerebellar tissue reference. PiB retention was significantly higher in DLB than in any of the other diagnostic groups. PiB retention did not differ across PDD, PD-MCI, PD, and HCS. Amyloid burden increased with age and with the presence of the ApoE ε4 allele in all patient groups. Only in the DLB group was amyloid deposition associated with impaired cognition. DLB subjects have higher amyloid burden than subjects with PDD, PD-MCI, PD, or HCS; amyloid deposits are linked to cognitive impairment only in DLB. Early amyloid deposits in DLB relative to PDD may account for their difference in the timing of dementia and parkinsonism.

  16. Luteolin attenuates endotoxin-induced uveitis in Lewis rats

    PubMed Central

    KANAI, Kazutaka; HATTA, Takuya; NAGATA, Sho; SUGIURA, Yuichi; SATO, Kazuaki; YAMASHITA, Yohei; KIMURA, Yuya; ITOH, Naoyuki

    2016-01-01

    The aim of the present study was to investigate the efficacy of luteolin on endotoxin-induced uveitis (EIU) in rats. EIU was induced in Lewis rats by subcutaneous injections of lipopolysaccharide (LPS). One hr before the LPS injection, 0.1, 1 or 10 mg/kg luteolin or 1 mg/kg prednisolone was intraperitoneally injected. We investigated its effect upon clinical scores, cellular infiltration and protein leakage, as well as on the level of tumor necrosis factor (TNF)-α, nitric oxide (NO) and prostaglandin (PG) E2 in the aqueous humor (AqH). Histologic examination and immunohistochemical analysis in the iris-ciliary body (ICB) were performed to determine the expressions of cyclooxygenase (COX)-2 and inducible NO synthase (iNOS), and then the activated nuclear factor (NF)-κB p65, I kappa B (IκB)-α degradation, phosphorylated (p)-IκB kinase (IKK) α/β and activator protein (AP)-1 c-Jun. Luteolin suppressed, in a dose-dependent manner, the clinical scores, number of inflammatory cells, the protein concentration, and the TNF-α, NO and PGE2 levels in the AqH and improved the histiologic status of the ocular tissue. Luteolin suppressed the expression of iNOS and COX-2 and the activated NF-κB p65, IκB-α degradation, p-IKKα/β and AP-1 p-c-Jun in the ICB. The anti-inflammatory potency of 10 mg/kg luteolin was as strong as that observed with 1 mg/kg prednisolone. These results demonstrate that luteolin attenuates ocular inflammation by inhibiting expression and release of inflammatory markers, along with the inhibition of the activated NF-κB pathway and at least partly AP-1 activity in the ICB. PMID:27098110

  17. 1,2-Diphosphonium dication: a strong P-based Lewis acid in frustrated lewis pair (FLP)-activations of B-H, Si-H, C-H, and H-H bonds.

    PubMed

    Holthausen, Michael H; Bayne, Julia M; Mallov, Ian; Dobrovetsky, Roman; Stephan, Douglas W

    2015-06-17

    A highly Lewis acidic diphosphonium dication [(C10H6)(Ph2P)2](2+) (1), in combination with a Lewis basic phosphine, acts as a purely phosphorus-based frustrated Lewis pair (FLP) and abstracts hydride from [HB(C6F5)3](-) and Et3SiH demonstrating the remarkable hydridophilicity of 1. The P-based FLP is also shown to activate H2 and C-H bonds.

  18. Uptake and Effects of the e-Vita Personal Health Record with Self-Management Support and Coaching, for Type 2 Diabetes Patients Treated in Primary Care

    PubMed Central

    van Vugt, M.; de Wit, M.; Sieverink, F.; Roelofsen, Y.; Hendriks, S. H.; Bilo, H. J. G.; Snoek, F. J.

    2016-01-01

    We studied the use, uptake, and effects of e-Vita, a personal health record, with self-management support and personalized asynchronized coaching, for type 2 diabetes patients treated in primary care. Patients were invited by their practice nurse to join the study aimed at testing use and effects of a personal health record. Patients were followed up for 6 months. Uptake and usage were monitored using log data. Outcomes were self-reported diabetes self-care, diabetes-related distress, and emotional wellbeing. Patients' health status was collected from their medical chart. 132 patients agreed to participate in the study of which less than half (46.1%) did not return to the personal health record after 1st login. Only 5 patients used the self-management support program within the personal health record, 3 of whom asked a coach for feedback. Low use of the personal health record was registered. No statistical significant differences on any of the outcome measures were found between baseline and 6 month follow-up. This study showed minimal impact of implementing a personal health record including self-management support in primary diabetes care. Successful adoption of web-based platforms, as ongoing patient centered care, is hard to achieve without additional strategies aimed at enhancing patient motivation and engaging professionals. PMID:26955640

  19. Menaquinone-7 Supplementation to Reduce Vascular Calcification in Patients with Coronary Artery Disease: Rationale and Study Protocol (VitaK-CAC Trial).

    PubMed

    Vossen, Liv M; Schurgers, Leon J; van Varik, Bernard J; Kietselaer, Bas L J H; Vermeer, Cees; Meeder, Johannes G; Rahel, Braim M; van Cauteren, Yvonne J M; Hoffland, Ge A; Rennenberg, Roger J M W; Reesink, Koen D; de Leeuw, Peter W; Kroon, Abraham A

    2015-10-28

    Coronary artery calcification (CAC) develops early in the pathogenesis of atherosclerosis and is a strong and independent predictor of cardiovascular disease (CVD). Arterial calcification is caused by an imbalance in calcification regulatory mechanisms. An important inhibitor of calcification is vitamin K-dependent matrix Gla protein (MGP). Both preclinical and clinical studies have shown that inhibition of the vitamin K-cycle by vitamin K antagonists (VKA) results in elevated uncarboxylated MGP (ucMGP) and subsequently in extensive arterial calcification. This led us to hypothesize that vitamin K supplementation may slow down the progression of calcification. To test this, we designed the VitaK-CAC trial which analyses effects of menaquinone-7 (MK-7) supplementation on progression of CAC. The trial is a double-blind, randomized, placebo-controlled trial including patients with coronary artery disease (CAD). Patients with a baseline Agatston CAC-score between 50 and 400 will be randomized to an intervention-group (360 microgram MK-7) or a placebo group. Treatment duration will be 24 months. The primary endpoint is the difference in CAC-score progression between both groups. Secondary endpoints include changes in arterial structure and function, and associations with biomarkers. We hypothesize that treatment with MK-7 will slow down or arrest the progression of CAC and that this trial may lead to a treatment option for vascular calcification and subsequent CVD.

  20. Menaquinone-7 Supplementation to Reduce Vascular Calcification in Patients with Coronary Artery Disease: Rationale and Study Protocol (VitaK-CAC Trial)

    PubMed Central

    Vossen, Liv M.; Schurgers, Leon J.; van Varik, Bernard J.; Kietselaer, Bas L. J. H.; Vermeer, Cees; Meeder, Johannes G.; Rahel, Braim M.; van Cauteren, Yvonne J. M.; Hoffland, Ge A.; Rennenberg, Roger J. M. W.; Reesink, Koen D.; de Leeuw, Peter W.; Kroon, Abraham A.

    2015-01-01

    Coronary artery calcification (CAC) develops early in the pathogenesis of atherosclerosis and is a strong and independent predictor of cardiovascular disease (CVD). Arterial calcification is caused by an imbalance in calcification regulatory mechanisms. An important inhibitor of calcification is vitamin K-dependent matrix Gla protein (MGP). Both preclinical and clinical studies have shown that inhibition of the vitamin K-cycle by vitamin K antagonists (VKA) results in elevated uncarboxylated MGP (ucMGP) and subsequently in extensive arterial calcification. This led us to hypothesize that vitamin K supplementation may slow down the progression of calcification. To test this, we designed the VitaK-CAC trial which analyses effects of menaquinone-7 (MK-7) supplementation on progression of CAC. The trial is a double-blind, randomized, placebo-controlled trial including patients with coronary artery disease (CAD). Patients with a baseline Agatston CAC-score between 50 and 400 will be randomized to an intervention-group (360 microgram MK-7) or a placebo group. Treatment duration will be 24 months. The primary endpoint is the difference in CAC-score progression between both groups. Secondary endpoints include changes in arterial structure and function, and associations with biomarkers. We hypothesize that treatment with MK-7 will slow down or arrest the progression of CAC and that this trial may lead to a treatment option for vascular calcification and subsequent CVD. PMID:26516910

  1. Pathways of nitrogen assimilation in cowpea nodules studied using /sup 15/N/sub 2/ and allopurinol. [Vigna unguiculata L. Walp. cv Vita

    SciTech Connect

    Atkins, C.A.; Storer, P.J.; Pate, J.S.

    1988-01-01

    In the presence of 0.5 millimolar allopurinol (4-hydroxypyrazolo (3,4-d)pyrimidine), an inhibitor of NAD:xanthine oxidoreductase (EC 1.2.3.2), intact attached nodules of cowpea (vigna unguiculata L. Walp. cv Vita 3) formed (/sup 15/N)xanthine from /sup 15/N/sub 2/ at rates equivalent to those of ureide synthesis, confirming the direct assimilation of fixed nitrogen into purines. Xanthine accumulated in nodules and was exported in increasing amounts in xylem of allopurinol-treated plants. Other intermediates of purine oxidation, de novo purine synthesis, and ammonia assimilation did not increase and, over the time course of experiments (4 hours), allopurinol had no effect on nitrogenase (EC 1.87.99.2) activity. Negligible /sup 15/N -labeling of asparagine from /sup 15/N/sub 2/ was observed, suggesting that the significant pool (up to 14 micromoles per gram of nodule fresh weight) of this amide in cowpea nodules was not formed directly from fixation but may have accumulated as a consequence of phloem delivery.

  2. Uptake and Effects of the e-Vita Personal Health Record with Self-Management Support and Coaching, for Type 2 Diabetes Patients Treated in Primary Care.

    PubMed

    van Vugt, M; de Wit, M; Sieverink, F; Roelofsen, Y; Hendriks, S H; Bilo, H J G; Snoek, F J

    2016-01-01

    We studied the use, uptake, and effects of e-Vita, a personal health record, with self-management support and personalized asynchronized coaching, for type 2 diabetes patients treated in primary care. Patients were invited by their practice nurse to join the study aimed at testing use and effects of a personal health record. Patients were followed up for 6 months. Uptake and usage were monitored using log data. Outcomes were self-reported diabetes self-care, diabetes-related distress, and emotional wellbeing. Patients' health status was collected from their medical chart. 132 patients agreed to participate in the study of which less than half (46.1%) did not return to the personal health record after 1st login. Only 5 patients used the self-management support program within the personal health record, 3 of whom asked a coach for feedback. Low use of the personal health record was registered. No statistical significant differences on any of the outcome measures were found between baseline and 6 month follow-up. This study showed minimal impact of implementing a personal health record including self-management support in primary diabetes care. Successful adoption of web-based platforms, as ongoing patient centered care, is hard to achieve without additional strategies aimed at enhancing patient motivation and engaging professionals.

  3. Historical perspectives - The role of the NASA Lewis Research Center in the national space nuclear power programs

    NASA Technical Reports Server (NTRS)

    Bloomfield, H. S.; Sovie, R. J.

    1991-01-01

    The history of the NASA Lewis Research Center's role in space nuclear power programs is reviewed. Lewis has provided leadership in research, development, and the advancement of space power and propulsion systems. Lewis' pioneering efforts in nuclear reactor technology, shielding, high temperature materials, fluid dynamics, heat transfer, mechanical and direct energy conversion, high-energy propellants, electric propulsion and high performance rocket fuels and nozzles have led to significant technical and management roles in many natural space nuclear power and propulsion programs.

  4. Historical perspectives: The role of the NASA Lewis Research Center in the national space nuclear power programs

    NASA Technical Reports Server (NTRS)

    Bloomfield, H. S.; Sovie, R. J.

    1991-01-01

    The history of the NASA Lewis Research Center's role in space nuclear power programs is reviewed. Lewis has provided leadership in research, development, and the advancement of space power and propulsion systems. Lewis' pioneering efforts in nuclear reactor technology, shielding, high temperature materials, fluid dynamics, heat transfer, mechanical and direct energy conversion, high-energy propellants, electric propulsion and high performance rocket fuels and nozzles have led to significant technical and management roles in many national space nuclear power and propulsion programs.

  5. Effectiveness of low-dose pregabalin in three patients with Lewy body disease and central neuropathic pain.

    PubMed

    Ukai, Katsuyuki; Fujishiro, Hiroshige; Ozaki, Norio

    2017-03-01

    Many patients with Lewy body disease complain of pain, and their pain may be associated with this disease. Recently, pain has become a focus of attention in Parkinson's disease, but there is little information regarding pain in patients who have dementia with Lewy bodies. We used pregabalin to treat three Lewy body disease patients with chronic pain that may have been related to degeneration of central neurons. All three patients responded well to pregabalin at 25-50 mg/day. To our knowledge, there have been no previous reports of pregabalin showing efficacy for central neuropathic pain in Parkinson's disease or Lewy body disease.

  6. Adaptive numerical simulation of pulsating planar flames for large Lewis and Zeldovich ranges

    NASA Astrophysics Data System (ADS)

    Roussel, Olivier; Schneider, Kai

    2006-06-01

    We study numerically the behaviour of pulsating planar flames in the thermo-diffusive approximation. The numerical scheme is based on a finite volume discretization with an adaptive multi-resolution technique for automatic grid adaption. This allows an accurate and efficient computation of pulsating flames even for very large activation energies. Depending on the Lewis number and the Zeldovich number, we observe different behaviours, like stable or pulsating flames, the latter being either damped, periodic, or a-periodic. A bifurcation diagram in the Lewis-Zeldovich plane is computed and our results are compared with previous computations [Rogg B. The effect of Lewis number greater than unity on an unsteady propagating flame with one-step chemistry. In: Peters N, Warnatz J, editors, Numerical methods in laminar flame propagation, Notes on numerical fluid mechanics, vol. 6. Vieweg; 1982. p. 38-48.] and theoretical predictions [Joulin G, Clavin P. Linear stability analysis of nonadiabatic flames: diffusional-thermal model. Combust Flame 1979;35:139-53]. For Lewis numbers larger than 6 we find that the stability limit is again increasing towards larger Zeldovich numbers and not monotonically decreasing as predicted by the asymptotic theory. A study of the flame velocities for different Zeldovich numbers shows that the amplitude of the pulsations strongly varies with the Lewis number. A Fourier analysis yields information on their frequency.

  7. Assessment of the constant non-unity Lewis number assumption in chemically-reacting flows

    NASA Astrophysics Data System (ADS)

    Burali, Nicholas; Lapointe, Simon; Bobbitt, Brock; Blanquart, Guillaume; Xuan, Yuan

    2016-07-01

    Accurate computation of molecular diffusion coefficients in chemically reacting flows can be an expensive procedure, and the use of constant non-unity Lewis numbers has been adopted often as a cheaper alternative. The goal of the current work is to explore the validity and the limitations of the constant non-unity Lewis number approach in the description of molecular mixing in laminar and turbulent flames. To carry out this analysis, three test cases have been selected, including a lean, highly unstable, premixed hydrogen/air flame, a lean turbulent premixed n-heptane/air flame, and a laminar ethylene/air coflow diffusion flame. For the hydrogen flame, both a laminar and a turbulent configuration have been considered. The three flames are characterised by Lewis numbers which are less than unity, greater than unity, and close to unity, respectively. For each flame, mixture-averaged transport simulations are carried out and used as reference data. The current analysis suggests that, for numerous combustion configurations, the constant non-unity Lewis number approximation leads to small errors when the set of Lewis numbers is chosen properly. For the selected test cases and our numerical framework, the reduction of computational cost is found to be minimal.

  8. Neural correlates of attention‐executive dysfunction in lewy body dementia and Alzheimer's disease

    PubMed Central

    Kobeleva, Xenia; Cherry, George; Killen, Alison; Gallagher, Peter; Burn, David J.; Thomas, Alan J.; O'Brien, John T.; Taylor, John‐Paul

    2015-01-01

    Abstract Attentional and executive dysfunction contribute to cognitive impairment in both Lewy body dementia and Alzheimer's disease. Using functional MRI, we examined the neural correlates of three components of attention (alerting, orienting, and executive/conflict function) in 23 patients with Alzheimer's disease, 32 patients with Lewy body dementia (19 with dementia with Lewy bodies and 13 with Parkinson's disease with dementia), and 23 healthy controls using a modified Attention Network Test. Although the functional MRI demonstrated a similar fronto‐parieto‐occipital network activation in all groups, Alzheimer's disease and Lewy body dementia patients had greater activation of this network for incongruent and more difficult trials, which were also accompanied by slower reaction times. There was no recruitment of additional brain regions or, conversely, regional deficits in brain activation. The default mode network, however, displayed diverging activity patterns in the dementia groups. The Alzheimer's disease group had limited task related deactivations of the default mode network, whereas patients with Lewy body dementia showed heightened deactivation to all trials, which might be an attempt to allocate neural resources to impaired attentional networks. We posit that, despite a common endpoint of attention‐executive disturbances in both dementias, the pathophysiological basis of these is very different between these diseases. Hum Brain Mapp 37:1254–1270, 2016. © 2015 The Authors Human Brain Mapping Published by Wiley Periodicals, Inc. PMID:26705763

  9. The effects of isoflurane on airway smooth muscle crossbridge kinetics in Fisher and Lewis rats.

    PubMed

    Duracher, Caroline; Blanc, François-Xavier; Gueugniaud, Pierre-Yves; David, Jean Stéphane; Riou, Bruno; Lecarpentier, Yves; Coirault, Catherine

    2005-07-01

    Our aim was to determine how isoflurane modified crossbridge (CB) number and kinetics in airway smooth muscle (ASM) and to compare its effects in Fisher and Lewis rats, two strains with differences in airway responsiveness. The effects of isoflurane (2 MAC) on isotonic and isometric contractility in tracheal ASM strips were investigated after methacholine (10(-6) M)-induced contraction. CB mechanics and kinetics were analyzed using the formalism of Huxley's equations adapted to ASM. After isoflurane, maximum velocity did not differ from baseline in Lewis rats, whereas it was significantly less than baseline in Fisher rats ( approximately 25%), the most reactive strain. Isoflurane totally reversed methacholine-induced increase in active CB number in Lewis rats (2.4 +/- 0.5 versus 1.8 +/- 0.4 10(9)/mm(2) after methacholine and isoflurane, respectively) whereas reversal was only partial in Fisher rats (2.7 +/- 0.4 versus 2.1 +/- 0.3 10(9)/mm(2) after methacholine and isoflurane, respectively). Isoflurane induced a 40% increase in attachment step duration in both strains and an almost twofold increase in the CB cycle duration compared with baseline in Lewis rats. The isoflurane-induced increase in detachment step duration was less in Lewis than in Fisher rats (P < 0.05). We concluded that isoflurane modulated CB number and CB cycling rates of isolated rat ASM differently depending on the level of airway responsiveness.

  10. Deubiquitinase Usp8 regulates α-synuclein clearance and modifies its toxicity in Lewy body disease.

    PubMed

    Alexopoulou, Zoi; Lang, Johannes; Perrett, Rebecca M; Elschami, Myriam; Hurry, Madeleine E D; Kim, Hyoung Tae; Mazaraki, Dimitra; Szabo, Aron; Kessler, Benedikt M; Goldberg, Alfred Lewis; Ansorge, Olaf; Fulga, Tudor A; Tofaris, George K

    2016-08-09

    In Parkinson's disease, misfolded α-synuclein accumulates, often in a ubiquitinated form, in neuronal inclusions termed Lewy bodies. An important outstanding question is whether ubiquitination in Lewy bodies is directly relevant to α-synuclein trafficking or turnover and Parkinson's pathogenesis. By comparative analysis in human postmortem brains, we found that ubiquitin immunoreactivity in Lewy bodies is largely due to K63-linked ubiquitin chains and markedly reduced in the substantia nigra compared with the neocortex. The ubiquitin staining in cells with Lewy bodies inversely correlated with the content and pathological localization of the deubiquitinase Usp8. Usp8 interacted and partly colocalized with α-synuclein in endosomal membranes and, both in cells and after purification, it deubiquitinated K63-linked chains on α-synuclein. Knockdown of Usp8 in the Drosophila eye reduced α-synuclein levels and α-synuclein-induced eye toxicity. Accordingly, in human cells, Usp8 knockdown increased the lysosomal degradation of α-synuclein. In the dopaminergic neurons of the Drosophila model, unlike knockdown of other deubiquitinases, Usp8 protected from α-synuclein-induced locomotor deficits and cell loss. These findings strongly suggest that removal of K63-linked ubiquitin chains on α-synuclein by Usp8 is a critical mechanism that reduces its lysosomal degradation in dopaminergic neurons and may contribute to α-synuclein accumulation in Lewy body disease.

  11. Deubiquitinase Usp8 regulates α-synuclein clearance and modifies its toxicity in Lewy body disease

    PubMed Central

    Alexopoulou, Zoi; Lang, Johannes; Perrett, Rebecca M.; Elschami, Myriam; Hurry, Madeleine E. D.; Kim, Hyoung Tae; Mazaraki, Dimitra; Szabo, Aron; Kessler, Benedikt M.; Goldberg, Alfred Lewis; Ansorge, Olaf; Fulga, Tudor A.; Tofaris, George K.

    2016-01-01

    In Parkinson’s disease, misfolded α-synuclein accumulates, often in a ubiquitinated form, in neuronal inclusions termed Lewy bodies. An important outstanding question is whether ubiquitination in Lewy bodies is directly relevant to α-synuclein trafficking or turnover and Parkinson’s pathogenesis. By comparative analysis in human postmortem brains, we found that ubiquitin immunoreactivity in Lewy bodies is largely due to K63-linked ubiquitin chains and markedly reduced in the substantia nigra compared with the neocortex. The ubiquitin staining in cells with Lewy bodies inversely correlated with the content and pathological localization of the deubiquitinase Usp8. Usp8 interacted and partly colocalized with α-synuclein in endosomal membranes and, both in cells and after purification, it deubiquitinated K63-linked chains on α-synuclein. Knockdown of Usp8 in the Drosophila eye reduced α-synuclein levels and α-synuclein–induced eye toxicity. Accordingly, in human cells, Usp8 knockdown increased the lysosomal degradation of α-synuclein. In the dopaminergic neurons of the Drosophila model, unlike knockdown of other deubiquitinases, Usp8 protected from α-synuclein–induced locomotor deficits and cell loss. These findings strongly suggest that removal of K63-linked ubiquitin chains on α-synuclein by Usp8 is a critical mechanism that reduces its lysosomal degradation in dopaminergic neurons and may contribute to α-synuclein accumulation in Lewy body disease. PMID:27444016

  12. Slow reactant-water exchange and high catalytic performance of water-tolerant Lewis acids.

    PubMed

    Koito, Yusuke; Nakajima, Kiyotaka; Kobayashi, Hisayoshi; Hasegawa, Ryota; Kitano, Masaaki; Hara, Michikazu

    2014-06-23

    (31)P nuclear magnetic resonance (NMR) spectroscopic measurement with trimethylphosphine oxide (TMPO) was applied to evaluate the Lewis acid catalysis of various metal triflates in water. The original (31)P NMR chemical shift and line width of TMPO is changed by the direct interaction of TMPO molecules with the Lewis acid sites of metal triflates. [Sc(OTf)3] and [In(OTf)3] had larger changes in (31)P chemical shift and line width by formation of the Lewis acid-TMPO complex than other metal triflates. It originates from the strong interaction between the Lewis acid and TMPO, which results in higher stability of [Sc(OTf)3TMPO] and [In(OTf)3TMPO] complexes than other metal triflate-TMPO complexes. The catalytic activities of [Sc(OTf)3] and [In(OTf)3] for Lewis acid-catalyzed reactions with carbonyl compounds in water were far superior to the other metal triflates, which indicates that the high stability of metal triflate-carbonyl compound complexes cause high catalytic performance for these reactions. Density functional theory (DFT) calculation suggests that low LUMO levels of [Sc(OTf)3] and [In(OTf)3] would be responsible for the formation of stable coordination intermediate with nucleophilic reactant in water.

  13. Neural correlates of attention-executive dysfunction in lewy body dementia and Alzheimer's disease.

    PubMed

    Firbank, Michael; Kobeleva, Xenia; Cherry, George; Killen, Alison; Gallagher, Peter; Burn, David J; Thomas, Alan J; O'Brien, John T; Taylor, John-Paul

    2016-03-01

    Attentional and executive dysfunction contribute to cognitive impairment in both Lewy body dementia and Alzheimer's disease. Using functional MRI, we examined the neural correlates of three components of attention (alerting, orienting, and executive/conflict function) in 23 patients with Alzheimer's disease, 32 patients with Lewy body dementia (19 with dementia with Lewy bodies and 13 with Parkinson's disease with dementia), and 23 healthy controls using a modified Attention Network Test. Although the functional MRI demonstrated a similar fronto-parieto-occipital network activation in all groups, Alzheimer's disease and Lewy body dementia patients had greater activation of this network for incongruent and more difficult trials, which were also accompanied by slower reaction times. There was no recruitment of additional brain regions or, conversely, regional deficits in brain activation. The default mode network, however, displayed diverging activity patterns in the dementia groups. The Alzheimer's disease group had limited task related deactivations of the default mode network, whereas patients with Lewy body dementia showed heightened deactivation to all trials, which might be an attempt to allocate neural resources to impaired attentional networks. We posit that, despite a common endpoint of attention-executive disturbances in both dementias, the pathophysiological basis of these is very different between these diseases.

  14. Mapping and analyzing Conservation Reserve Program (CRP) enrollment patterns from 1991 to 2011 in Nelson County, North Dakota, using remote sensing and GIS techniques

    NASA Astrophysics Data System (ADS)

    Roehrdanz, Nicholas L.

    Since its inception in 1985, the federally managed Conservation Reserve Program (CRP) has contributed to land-use/land-cover change (LUCC) in areas throughout North Dakota. Concurrently, the Devils Lake Basin and surrounding Prairie Pothole Region (PPR) in North Dakota has experienced pervasive lake and wetland flooding. Unsurprisingly, a clustering of CRP enrollment in certain counties within the basin has occurred, seemingly coinciding with the flooding. Analysis of historical county-level CRP enrollment data pertaining to counties in North Dakota revealed that Nelson County, which is partially within the basin, has developed as a CRP hotspot in the state and has had the greatest increase in the density of CRP acreage amongst the counties in the region. We hypothesize that this high enrollment is the response of farmers losing arable lands and/or field access to the rising waters in the region, thus making CRP enrollment an economically viable option. This study uses Landsat data and GIS analysis to document LUCC and the forces driving it associated with CRP grassland and pervasive lake and wetland flooding in Nelson County. Because CRP field locations are not available from the federal government, we used multi-temporal classification techniques (three scenes per year) to derive land-cover maps from Landsat Thematic Mapper data for five growing seasons (1984, 1991, 1998, 2005, and 2011). We mapped CRP grassland at more than 90% accuracy with validation data derived from interpretation of historical aerial photography and, in the case of 2011, data gathered in the field. LUCC change analysis was done using raster GIS. We found an increase in the amount of CRP grassland in the study area between 1991 (19,688 ha) and 2005 (35,612 ha) and then a decline to 2011 (27,856 ha). Spatial analysis revealed a clustering of CRP in 1991 in the Sheyenne and Goose river valleys, likely attributable to those lands being considered of greater conservation importance. By 1998, a

  15. Lewis-Acid/Base Effects on Gallium Volatility in Molten Chlorides

    SciTech Connect

    Williams, D.F.

    2001-02-26

    It has been proposed that GaCl{sub 3} can be removed by direct volatilization from a Pu-Ga alloy that is dissolved in a molten chloride salt. Although pure GaCl{sub 3} is quite volatile (boiling point, 201 C), the behavior of GaCl{sub 3} dissolved in chloride salts is different due to solution effects and is critically dependent on the composition of the solvent salt (i.e., its Lewis-acid/base character). In this report, the behavior of gallium in prototypical Lewis-acid and Lewis-base salts is compared. It was found that gallium volatility is suppressed in basic melts and enhanced in acidic melts. The implications of these results on the potential for simple gallium removal in molten salt systems are significant.

  16. On the behaviour of biradicaloid [P(μ-NTer)]2 towards Lewis acids and bases.

    PubMed

    Hinz, Alexander; Schulz, Axel; Villinger, Alexander

    2016-05-07

    The well-known diphosphadiazane-1,3-diyl [P(μ-NTer)]2 (Ter = 2,6-bis(2,4,6-trimethyl-phenyl)-phenyl) was treated with Lewis bases such as N-heterocyclic carbenes and Lewis acids e.g. gold(i) chloride complexes. In the reaction with the Lewis base, fragmentation of the P2N2 framework was observed, yielding a salt of the type [(NHC)2P](+)[(TerN)2P](-) in a clean reaction. The reaction of [P(μ-NTer)]2 with gold(i) chloride afforded 1 : 1 and 1 : 2 complexes. The dinuclear complex [(ClAu)2P(μ-NTer)2P] displays a bridging P atom between both gold centers, as has been observed for P based zwitterions.

  17. In between worlds: G.N. Lewis, the shared pair bond and its multifarious contexts.

    PubMed

    Simões, Ana

    2007-01-15

    In this paper, I will look at the rather convoluted discovery process which gave birth to the concept of the shared electron pair bond as developed by G.N. Lewis, to be subsequently appropriated by the American founders of quantum chemistry, and highlight the complex relations between conceptual development and the different contexts in which ideas are created and presented. I will show how the successive installments of Lewis's model of the chemical bond were supported by and gained credence from an epistemological background in which Lewis explored the relations of chemistry to physics. Furthermore, they were shaped by the changing public contexts in which the successive metamorphoses of the ideas took place and their epistemological background was outlined and explored. The complexities which are always associated with a discovery process can therefore be illuminated if one pays attention to different interactive realms-the conceptual, epistemological, and the presentational one.

  18. NASA-ASEE Summer Faculty Fellowship Program at NASA Lewis Research Center

    NASA Technical Reports Server (NTRS)

    Prahl, Joseph M.; Keith, Theo G., Jr.; Montegani, Francis J.

    1996-01-01

    During the summer of 1996, a ten-week Summer Faculty Fellowship Program was conducted at the NASA Lewis Research Center (LeRC) in collaboration with Case Western Reserve University (CWRU), and the Ohio Aerospace Institute (OAI). This is the thirty-third summer of this program at Lewis. It was one of nine summer programs sponsored by NASA in 1996, at various field centers under the auspices of the American Society for Engineering Education (ASEE). The objectives of the program are: (1) to further the professional knowledge of qualified engineering and science educators, (2) to stimulate an exchange of ideas between participants and NASA, (3) to enrich and refresh the research activities of participants' institutions. (4) to contribute to the research objectives of LeRC. This report is intended to recapitulate the activities comprising the 1996 Lewis Summer Faculty Fellowship Program, to summarize evaluations by the participants, and to make recommendations regarding future programs.

  19. Imaging amyloid in Parkinson's disease dementia and dementia with Lewy bodies with positron emission tomography.

    PubMed

    Brooks, David J

    2009-01-01

    Although Parkinson's disease with later dementia (PDD) and dementia with Lewy bodies (DLB) are pathologically characterized by the presence of intraneuronal Lewy inclusion bodies, amyloid deposition is also associated to varying degrees with both these disorders. Fibrillar amyloid load can now be quantitated in vivo with positron emission tomography (PET) using imaging biomarkers. Here the reported findings of 11C-PIB PET studies concerning the amyloid load associated with PD and its influence on dementia are reviewed. It is concluded that the presence of amyloid acts to accelerate the dementia process in Lewy body disorders, though has little influence on its nature. Anti-amyloid strategies could be a relevant approach for slowing dementia in a number of DLB and PDD cases.

  20. End of Frustration: Catalytic Precision Polymerization with Highly Interacting Lewis Pairs.

    PubMed

    Knaus, Maximilian G M; Giuman, Marco M; Pöthig, Alexander; Rieger, Bernhard

    2016-06-22

    Herein we report on the catalytic polymerization of diverse Michael-type monomers with high precision by using simple but highly active combinations of phosphorus-containing Lewis bases and organoaluminum compounds. The interacting Lewis pair catalysts enable the control of molecular weight and microstructure of the produced polymers. The reactions show a linear Mn vs consumption plot thus proving a living type polymerization. The initiation has been investigated by end-group analysis with ESI mass spectrometric analysis. With these main-group element Lewis acid base pairs, it is not only possible to polymerize sterically demanding, functionalized as well as heteroatom containing monomers but also, for the first time, to catalytically polymerize extended Michael systems, like 4-vinylpyridine.

  1. Lewis Acidity/Basicity Changes in Imidazolium Based Ionic Liquids Brought About by Impurities.

    PubMed

    Gazitúa, Marcela; Fuentealba, Patricio; Contreras, Renato; Ormazábal-Toledo, Rodrigo

    2015-10-15

    We herein report on the effect that water molecules, present as impurities, in the vicinity of an ionic liquid model structure, may induce on the Lewis acidity/basicity patterns normally observed in these materials. Depending on the position and orientation of water, the Lewis acidity/basicity pattern changes from "normal distribution" (i.e., the basicity located at the anion moiety and the acidity located at the cation fragment) to "bifunctional distribution" (i.e., the acidity and basicity located at the cation moiety). In some specific cases, there appears a third Lewis acidity/basicity distribution, where water may bind both the cation and the anion of the ion pair; a response we tentatively call "amphoteric". These effects are clearly traced to the hydrogen bond formation ability of water to coordinate different regions of pure ionic liquids taken as references.

  2. The NASA Langley building solar project and the supporting Lewis solar technology program

    NASA Technical Reports Server (NTRS)

    Ragsdale, R. G.; Namkoong, D.

    1974-01-01

    The use of solar energy to heat and cool a new office building that is now under construction is reported. Planned for completion in December 1975, the 53,000 square foot, single story building will utilize 15,000 square feet of various types of solar collectors in a test bed to provide nearly all of the heating demand and over half of the air conditioning demand. Drawing on its space-program-developed skills and resources in heat transfer, materials, and systems studies, NASA-Lewis will provide technology support for the Langley building project. A solar energy technology program underway at Lewis includes solar collector testing in an indoor solar simulator facility and in an outdoor test facility, property measurements of solar panel coatings, and operation of a laboratory-scale solar model system test facility. Based on results obtained in this program, NASA-Lewis will select and procure the solar collectors for the Langley test bed.

  3. A Frustrated Lewis Pair Catalyzed Asymmetric Transfer Hydrogenation of Imines Using Ammonia Borane.

    PubMed

    Li, Songlei; Li, Gen; Meng, Wei; Du, Haifeng

    2016-10-05

    Inspired by the zwitterion species generated from the splitting of H2 by frustrated Lewis pairs, we put forward a novel frustrated Lewis pair by the combination of H(δ-) and H(δ+) incorporated Lewis acid and base together. Piers' borane and chiral tert-butylsulfinamide were chosen as the FLP, and a metal-free asymmetric transfer hydrogenation of imines was realized with high enantioselectivities. Significantly, with ammonia borane as hydrogen source, a catalytic asymmetric reaction using 10 mol % of Piers' borane, chiral tert-butylsulfinamide, and pyridine additive, has been successfully achieved to furnish optically active amines in 78-99% yields with 84-95% ee's. Experimental and theoretical mechanistic studies reveal an interesting 8-membered ring hydrogen transfer transition state and an expected regeneration of reactive species with ammonia borane. Accordingly, a plausible catalytic pathway for this reaction is depicted.

  4. Two-Stage Indicators to Assess Learning Curves for Minimally Invasive Ivor Lewis Esophagectomy.

    PubMed

    Wang, Qi; Wu, Zixiang; Chen, Gang; Zhang, Sai; Shen, Gang; Wu, Ming

    2016-10-05

    Background Minimally invasive esophagectomy (MIE) Ivor Lewis has been increasingly performed over the last two decades. To guide the implementation of this technically demanding procedure, a comprehensive assessment of MIE-Ivor Lewis learning curves should include both the general competence to accomplish the procedure and the ability to generate oncological benefits. These objectives are believed to be associated with different phases of the learning curve. Methods A retrospective review of the first 109 patients who underwent MIE-Ivor Lewis by a single qualified surgeon was conducted. Relevant variables were collected and assessed by regression analysis to identify suitable indicators for patient stratification and learning curve assessment. Thereafter, the differential analysis was performed among groups to validate the learning curve model. Results Two variables, intrathoracic gastroesophageal anastomosis time and bilateral recurrent laryngeal nerve (RLN) lymphadenectomy number, which plateaued, respectively, after the 26th and 88th cases, were selected as meaningful indicators to identify different competence levels. Therefore, 109 patients were chronologically subcategorized into three groups (the first 26 MIEs as the early group, the next 62 cases as the middle group, and 21 most recent cases as the late group). Perioperative data were compared between groups with positive results to indicate a three-phase model for a learning curve for MIE-Ivor Lewis. Conclusions An MIE-Ivor Lewis learning curve should include three discrete phases that indicate, successively, unskilled operation (general competence to accomplish, less proficiency), surgical proficiency, and oncological efficacy. Intrathoracic anastomosis time and bilateral RLN lymphadenectomy were identified as suitable indicators delineate the different stages of an MIE-Ivor Lewis learning curve.

  5. Dementia With Lewy Bodies: Diagnosis and Management for Primary Care Providers

    PubMed Central

    Mahajan, Aman; Handa, Kamna

    2011-01-01

    Objective: The purpose of this review is to aid primary care providers in distinguishing dementia with Lewy bodies (DLB) from Alzheimer's disease and from Parkinson's disease with dementia. Differentiating these entities has important treatment implications. Data Sources: A PubMed search was undertaken using the keywords Lewy body dementia, dementia with Lewy bodies, and Lewy body disease. There were no date restrictions. Only articles in the English language were reviewed. References of selected articles were reviewed for additional sources. Data Selection and Extraction: Initially, 2,967 articles were retrieved. All 3 authors participated in data selection and extraction. Articles were further selected for content specific to epidemiology, clinical presentation, diagnostic studies, treatment, and prognosis. For articles with repetitive information, the most current article was used. This resulted in a total of 62 articles included in the review. Data Synthesis: Dementia with Lewy bodies is the second leading cause of dementia after Alzheimer's disease. The core symptoms of DLB, including cognitive fluctuations, visual hallucinations, and parkinsonism, may not always be present as a triad, and clinicians may be unaware of associated symptoms. Thus, this diagnosis is frequently missed by primary care providers. Often, DLB is misdiagnosed as Alzheimer's disease, Parkinson's disease, or a primary psychiatric illness. Treatments for DLB include cholinesterase inhibitors and N-methyl-D-aspartate antagonists. Antipsychotics should be avoided or used with caution. Conclusions: Dementia with Lewy bodies is an often missed diagnosis. Symptoms are often attributed to other disorders. A high clinical suspicion is helpful in accurate diagnosis, and presence of any of the core symptoms should initiate clinical suspicion of DLB. Distinguishing DLB from other disorders has important treatment implications. PMID:22295275

  6. Evaluation of a Stirling engine heater bypass with the NASA Lewis nodal-analysis performance code

    SciTech Connect

    Sullivan, T.J.

    1986-05-01

    In support of the US Department of Energy's Stirling Engine Highway Vehicle Systems program, the NASA Lewis Research Center investigated whether bypassing the P-40 Stirling engine heater during regenerative cooling would improve the engine thermal efficiency. The investigation was accomplished by using the Lewis nodal-analysis Stirling engine computer model. Bypassing the P-40 Stirling engine heater at full power resulted in a rise in the indicated thermal efficiency from 40.6 to 41.0 percent. For the idealized (some losses not included) heater bypass that was analyzed, this benefit is not considered significant.

  7. Initial results from the Solar Dynamic (SD) Ground Test Demonstration (GTD) project at NASA Lewis

    NASA Technical Reports Server (NTRS)

    Shaltens, Richard K.; Boyle, Robert V.

    1995-01-01

    A government/industry team designed, built, and tested a 2 kWe solar dynamic space power system in a large thermal/vacuum facility with a simulated sun at the NASA Lewis Research Center. The Lewis facility provides an accurate simulation of temperatures, high vacuum, and solar flux as encountered in low earth orbit. This paper reviews the goals and status of the Solar Dynamic (SD) Ground Test Demonstration (GTD) program and describes the initial testing, including both operational and performance data. This SD technology has the potential as a future power source for the International Space Station Alpha.

  8. Life prediction of turbine components: On-going studies at the NASA Lewis Research Center

    NASA Technical Reports Server (NTRS)

    Spera, D. A.; Grisaffe, S. J.

    1973-01-01

    An overview is presented of the many studies at NASA-Lewis that form the turbine component life prediction program. This program has three phases: (1) development of life prediction methods for major failure modes through materials studies, (2) evaluation and improvement of these methods through a variety of burner rig studies on simulated components in research engines and advanced rigs. These three phases form a cooperative, interdisciplinary program. A bibliography of Lewis publications on fatigue, oxidation and coatings, and turbine engine alloys is included.

  9. Solar photovoltaics: Stand alone applications. [NASA Lewis Research Center research and development

    NASA Technical Reports Server (NTRS)

    Deyo, J. N.

    1980-01-01

    The Lewis Research Center involvement in space photovoltaic research and development and in using photovoltaics for terrestrial applications is described with emphasis on applications in which the normal source of power may be a diesel generator, batteries, or other types of power not connected to a utility grid. Once an application is processed, technology is developed and demonstrated with a user who participates in the cost and furnishes the site. Projects completed related to instruments, communication, refrigeration, and highways, are described as well as warning systems, weather stations, fire lookouts, and village power systems. A commercially available photovoltaic powered electric fence charger is the result of Lewis research and development.

  10. Anatomy of an organizational change effort at the Lewis Research Center

    NASA Technical Reports Server (NTRS)

    Hawker, James R.; Dali, Richard S.

    1988-01-01

    By 1979, after a long decline following the end of the Apollo program, the Lewis Research Center found its very existence endangered because it was not doing the kind of research that could attract funding at the time. New management under Andrew J. Stofan applied a program of strategic planning, participative management, and consensus decision making. A corporate-cultural change was effected which enabled Lewis to commit itself to four fundable research and development projects. Morale-building and training programs which were essential to this change are described.

  11. 2-kW Solar Dynamic Space Power System Tested in Lewis' Thermal Vacuum Facility

    NASA Technical Reports Server (NTRS)

    1995-01-01

    Working together, a NASA/industry team successfully operated and tested a complete solar dynamic space power system in a large thermal vacuum facility with a simulated sun. This NASA Lewis Research Center facility, known as Tank 6 in building 301, accurately simulates the temperatures, high vacuum, and solar flux encountered in low-Earth orbit. The solar dynamic space power system shown in the photo in the Lewis facility, includes the solar concentrator and the solar receiver with thermal energy storage integrated with the power conversion unit. Initial testing in December 1994 resulted in the world's first operation of an integrated solar dynamic system in a relevant environment.

  12. Structural diversity and biological importance of ABO, H, Lewis and secretor histo-blood group carbohydrates.

    PubMed

    de Mattos, Luiz Carlos

    ABO, H, secretor and Lewis histo-blood system genes control the expression of part of the carbohydrate repertoire present in areas of the body occupied by microorganisms. These carbohydrates, besides having great structural diversity, act as potential receptors for pathogenic and non-pathogenic microorganisms influencing susceptibility and resistance to infection and illness. Despite the knowledge of some structural variability of these carbohydrate antigens and their polymorphic levels of expression in tissue and exocrine secretions, little is known about their biological importance and potential applications in medicine. This review highlights the structural diversity, the biological importance and potential applications of ABO, H, Lewis and secretor histo-blood carbohydrates.

  13. Chemoenzymatic Synthesis of Functional Sialyl LewisX Mimetics with a Heteroaromatic Core

    PubMed Central

    Schlemmer, Claudine; Wiebe, Christine; Ferenc, Dorota; Kowalczyk, Danuta; Wedepohl, Stefanie; Ziegelmüller, Patrick; Dernedde, Jens; Opatz, Till

    2014-01-01

    Functional mimetics of the sialyl LewisX tetrasaccharide were prepared by the enzymatic sialylation of a 1,3-diglycosylated indole and a glycosyl azide, which was subsequently transformed into a 1,4-diglycosylated 1,2,3-triazole, by using the trans-sialidase of Trypanosoma cruzi. These compounds inhibited the binding of E-, L-, and P-selectin-coated nanoparticles to polyacrylamide-bound sialyl-LewisX-containing neighboring sulfated tyrosine residues (sTyr/sLeX-PAA) at low or sub-millimolar concentrations. Except for E-selectin, the mimetics showed higher activities than the natural tetrasaccharide. PMID:24888318

  14. Estimation of rhG-CSF absorption kinetics after subcutaneous administration using a modified Wagner-Nelson method with a nonlinear elimination model.

    PubMed

    Hayashi, N; Aso, H; Higashida, M; Kinoshita, H; Ohdo, S; Yukawa, E; Higuchi, S

    2001-05-01

    The clearance of recombinant human granulocyte-colony stimulating factor (rhG-CSF) is known to decrease with dose increase, and to be saturable. The average clearance after intravenous administration will be lower than that after subcutaneous administration. Therefore, the apparent absolute bioavailability with subcutaneous administration calculated from the AUC ratio is expected to be an underestimate. The absorption pharmacokinetics after subcutaneous administration was examined using the results of the bioequivalency study between two rhG-CSF formulations with a dose of 2 microg/kg. The analysis was performed using a modified Wagner-Nelson method with the nonlinear elimination model. The apparent absolute bioavailability for subcutaneous administration was 56.9 and 67.5% for each formulation, and the ratio between them was approximately 120%. The true absolute bioavailability was, however, estimated to be 89.8 and 96.9%, respectively, and the ratio was approximately 108%. The absorption pattern was applied to other doses, and the predicted clearance values for subcutaneous and intravenous administrations were then similar to the values for several doses reported in the literature. The underestimation of bioavailability was around 30%, and the amplification of difference was 2.5 times, from 8 to 20%, because of the nonlinear pharmacokinetics. The neutrophil increases for each formulation were identical, despite the different bioavailabilities. The reason for this is probably that the amount eliminated through the saturable process, which might indicate the amount consumed by the G-CSF receptor, was identical for each formulation.

  15. Measurement invariance of big-five factors over the life span: ESEM tests of gender, age, plasticity, maturity, and la dolce vita effects.

    PubMed

    Marsh, Herbert W; Nagengast, Benjamin; Morin, Alexandre J S

    2013-06-01

    This substantive-methodological synergy applies evolving approaches to factor analysis to substantively important developmental issues of how five-factor-approach (FFA) personality measures vary with gender, age, and their interaction. Confirmatory factor analyses (CFAs) conducted at the item level often do not support a priori FFA structures, due in part to the overly restrictive assumptions of CFA models. Here we demonstrate that exploratory structural equation modeling (ESEM), an integration of CFA and exploratory factor analysis, overcomes these problems with the 15-item Big Five Inventory administered as part of the nationally representative British Household Panel Study (N = 14,021; age: 15-99 years, Mage = 47.1). ESEM fitted the data substantially better and resulted in much more differentiated (less correlated) factors than did CFA. Methodologically, we extended ESEM (introducing ESEM-within-CFA models and a hybrid of multiple groups and multiple indicators multiple causes models), evaluating full measurement invariance and latent mean differences over age, gender, and their interaction. Substantively the results showed that women had higher latent scores for all Big Five factors except for Openness and that these gender differences were consistent over the entire life span. Substantial nonlinear age effects led to the rejection of the plaster hypothesis and the maturity principle but did support a newly proposed la dolce vita effect in old age. In later years, individuals become happier (more agreeable and less neurotic), more self-content and self-centered (less extroverted and open), more laid back and satisfied with what they have (less conscientious, open, outgoing and extroverted), and less preoccupied with productivity.

  16. Differences Between Patients With Type 2 Diabetes Mellitus Interested and Uninterested in the Use of a Patient Platform (e-VitaDM-2/ZODIAC-41).

    PubMed

    Roelofsen, Yvonne; Hendriks, Steven H; Sieverink, Floor; Landman, Gijs W D; Groenier, Klaas H; Bilo, Henk J G; Kleefstra, Nanne

    2014-03-01

    The prevalence of type 2 diabetes mellitus (T2DM) is rising in the Netherlands, and health care's workload will increase. e-Health applications may increase patients' participation in their care and could help reducing workload. To explore potential users, differences in patients interested and uninterested in e-Health are characterized. A prospective cohort study was initiated in the Drenthe region of the Netherlands. This study included inviting T2DM patients to use e-Health (the e-Vita platform). Patients were offered access to clinical data, laboratory results, educational modules, and a self-management support program. Data were obtained from health record systems of general practices and questionnaires. Out of 2674 patients, 1378 (51.5%) participated in the study. Of the 1378 patients, 974 (70.7%) were interested in e-Health. Of 974, 405 (41.6%) were registered for e-Health. Interested patients were more often male, were younger, had shorter T2DM duration, and were higher educated. Of 405, 110 (27.2%) used the e-Health. No differences were found between users and nonusers of e-Health. Patients interested in e-Health were more often male, were younger, had shorter T2DM duration, and were more often higher educated. However, even in this interested group, the actual participation rate remained low. Together with characteristics and attitudes of caregivers and T2DM patients, the look and content of the e-Health platform strategies that increase interest and participation need to be developed.

  17. Differences Between Patients With Type 2 Diabetes Mellitus Interested and Uninterested in the Use of a Patient Platform (e-VitaDM-2/ZODIAC-41)

    PubMed Central

    Hendriks, Steven H.; Sieverink, Floor; Landman, Gijs W. D.; Groenier, Klaas H.; Bilo, Henk J. G.; Kleefstra, Nanne

    2014-01-01

    The prevalence of type 2 diabetes mellitus (T2DM) is rising in the Netherlands, and health care’s workload will increase. e-Health applications may increase patients’ participation in their care and could help reducing workload. To explore potential users, differences in patients interested and uninterested in e-Health are characterized. A prospective cohort study was initiated in the Drenthe region of the Netherlands. This study included inviting T2DM patients to use e-Health (the e-Vita platform). Patients were offered access to clinical data, laboratory results, educational modules, and a self-management support program. Data were obtained from health record systems of general practices and questionnaires. Out of 2674 patients, 1378 (51.5%) participated in the study. Of the 1378 patients, 974 (70.7%) were interested in e-Health. Of 974, 405 (41.6%) were registered for e-Health. Interested patients were more often male, were younger, had shorter T2DM duration, and were higher educated. Of 405, 110 (27.2%) used the e-Health. No differences were found between users and nonusers of e-Health. Patients interested in e-Health were more often male, were younger, had shorter T2DM duration, and were more often higher educated. However, even in this interested group, the actual participation rate remained low. Together with characteristics and attitudes of caregivers and T2DM patients, the look and content of the e-Health platform strategies that increase interest and participation need to be developed. PMID:24876572

  18. "OrganicPad": An Interactive Freehand Drawing Application for Drawing Lewis Structures and the Development of Skills in Organic Chemistry

    ERIC Educational Resources Information Center

    Cooper, Melanie M.; Grove, Nathaniel P.; Pargas, Roy; Bryfczynski, Sam P.; Gatlin, Todd

    2009-01-01

    Lewis structures are important for learning chemistry as they serve as an essential link between the structure of chemical compounds and their function. Unfortunately, the creation of valid Lewis structures remains an elusive goal for many students. In recent years, several web-based programs have been created that allow students to receive…

  19. Lewis base catalyzed [4+2] annulation of electron-deficient chromone-derived heterodienes and acetylenes.

    PubMed

    Dückert, Heiko; Khedkar, Vivek; Waldmann, Herbert; Kumar, Kamal

    2011-04-26

    Lewis base catalyzed [4+2] annulation reactions between electron-deficient chromone oxa- and azadienes and acetylene carboxylates provide tricyclic benzopyrones inspired by natural products. An asymmetric synthesis of the tricyclic benzopyrones was developed by using modified cinchona alkaloids as enantiodifferentiating Lewis base catalysts.

  20. Room-Temperature Activation of Hydrogen by Semi-immobilized Frustrated Lewis Pairs in Microporous Polymer Networks.

    PubMed

    Trunk, Matthias; Teichert, Johannes F; Thomas, Arne

    2017-03-15

    Porous polymer networks based on sterically encumbered triphenylphosphine motifs, mimicking the basic sites employed in frustrated Lewis pair (FLP) chemistry, were synthesized via Yamamoto polymerization and their interactions with the strong Lewis acid B(C6F5)3 probed. The combinations yield semi-immobilized FLPs, which are able to cleave dihydrogen heterolytically at ambient temperature and low hydrogen pressure.