17 CFR 210.12-12B - Open option contracts written.

Code of Federal Regulations, 2010 CFR

2010-04-01

... 17 Commodity and Securities Exchanges 2 2010-04-01 2010-04-01 false Open option contracts written... § 210.12-12B Open option contracts written. [For management investment companies only] Col. A Col. B Col... Information as to put options shall be shown separately from information as to call options. 2 Options of an...

48 CFR 14.401 - Receipt and safeguarding of bids.

Code of Federal Regulations, 2010 CFR

2010-10-01

... CONTRACTING METHODS AND CONTRACT TYPES SEALED BIDDING Opening of Bids and Award of Contract 14.401 Receipt and... identification, and then only by an official designated for this purpose. If a sealed bid is opened by mistake (e.g., because it is not marked as being a bid), the envelope shall be signed by the opener, whose...

Graduate Course Contract Law Deskbook (54th). Volume 2

DTIC Science & Technology

2005-01-01

GRADUATE COURSE THE FIFTY-FOURTH CONTRACT LAW DESKBOOK Contract and Fiscal Law Department The Judge Advocate General’s School, United States Army...OF ABSTRACT 8. 54th GC Contract Law Deskbook, Volume II, Fall 2005 1. AGENCY USE ONLY (Leave blank) 4. TITLE AND SUBTITLE 54th Graduate...Louisiana, 1998-1999; Contract Law Attorney, and Chief, Administrative Law, Office of the Staff Judge Advocate, Fort Polk, Louisiana, 1996-1998. Member

Advanced transportation system studies technical area 2 (TA-2): Heavy lift launch vehicle development. volume 3; Program Cost estimates

NASA Technical Reports Server (NTRS)

McCurry, J. B.

1995-01-01

The purpose of the TA-2 contract was to provide advanced launch vehicle concept definition and analysis to assist NASA in the identification of future launch vehicle requirements. Contracted analysis activities included vehicle sizing and performance analysis, subsystem concept definition, propulsion subsystem definition (foreign and domestic), ground operations and facilities analysis, and life cycle cost estimation. The basic period of performance of the TA-2 contract was from May 1992 through May 1993. No-cost extensions were exercised on the contract from June 1993 through July 1995. This document is part of the final report for the TA-2 contract. The final report consists of three volumes: Volume 1 is the Executive Summary, Volume 2 is Technical Results, and Volume 3 is Program Cost Estimates. The document-at-hand, Volume 3, provides a work breakdown structure dictionary, user's guide for the parametric life cycle cost estimation tool, and final report developed by ECON, Inc., under subcontract to Lockheed Martin on TA-2 for the analysis of heavy lift launch vehicle concepts.

23 CFR 635.113 - Bid opening and bid tabulations.

Code of Federal Regulations, 2010 CFR

2010-04-01

... CONSTRUCTION AND MAINTENANCE Contract Procedures § 635.113 Bid opening and bid tabulations. (a) All bids... contractors, during the period following the opening of bids and before the award of the contract shall not be...

Technical guide on documentation requirements for open market contract acquisitions of information resources

NASA Technical Reports Server (NTRS)

Shaw, Asa L., Jr.; Kivett, William R.; Taylor, James Y.

1990-01-01

A guide is presented to assist requestors in formulating and submitting the required Complete Package for Information Resources (IR) acquisitions. Advance discussions with cognizant procurement personnel are strongly recommended for complex IR requirements or for those requestors new to the acquisition process. Open Market means the requirement either is not available on GSA Schedule Contract or exceeds the $300,000 threshold and/or the quantity Maximum Order Limitation of the GSA Schedule Contract. Only open market contract acquisitions (i.e., in excess of the $25,000 small purchase threshold), are addressed.

Marine Corps Recruits: A Historical Look at Accessions and Bootcamp Performance

DTIC Science & Technology

2010-09-01

without the promise of an occupational field . Their code is PN, and these are called open contracts. In this slide, we graph the percentage of open ...means that occupational specialties such as infantry, armor, field artillery, and short-range air defense artillery are closed to women...enlistment contracts began for small numbers of Marines. While the 3 -, 4-, and 6-year initial enlistment contracts were open to the same group of MOSs

Effects of heart rate on experimentally produced mitral regurgitation in dogs.

PubMed

Yoran, C; Yellin, E L; Hori, M; Tsujioka, K; Laniado, S; Sonnenblick, E H; Frater, R W

1983-12-01

The effects of increasing heart rate (HR) on the hemodynamics of acute mitral regurgitation (MR) were studied in 8 open-chest dogs. Filling volume, regurgitant volume and stroke volume were calculated from electromagnetic probe measurements of mitral and aortic flows. The left atrial-left ventricular systolic pressure gradient was measured with micromanometers. The calculated effective mitral regurgitant orifice area varied from 10 to 128 mm2, with a consequent regurgitant fraction (regurgitant volume/filling volume) of 24 to 62%. After crushing the sinus node, HR was increased stepwise from 90 to 180 beats/min by atrial pacing while maintaining aortic pressure constant. With increasing HR, filling volume, stroke volume, regurgitant volume and regurgitant time decreased; total cardiac output, forward cardiac output, regurgitant output, systolic pressure gradient, regurgitant fraction and the regurgitant orifice did not change; left ventricular end-diastolic pressure decreased; and left atrial v-wave amplitude increased. These results indicate that in acute experimental MR with a wide spectrum of incompetence, the relative distribution of forward and regurgitant flows did not change with large increases in HR. At rates greater than 150 beats/min the atrial contraction occurs early and increases the amplitude of the left atrial v wave. This may contribute to the severity of pulmonary congestion in patients with MR.

48 CFR 6.303-1 - Requirements.

Code of Federal Regulations, 2010 CFR

2010-10-01

... accurate and complete necessary data to support their recommendation for other than full and open... COMPETITION REQUIREMENTS Other Than Full and Open Competition 6.303-1 Requirements. (a) A contracting officer... resulting from an unsolicited proposal, or award any other contract without providing for full and open...

Using a Modular Open Systems Approach in Defense Acquisitions: Implications for the Contracting Process

DTIC Science & Technology

2006-01-30

He has taught contract management courses for the UCLA Government Contracts Certificate program and is also a senior faculty member for the Keller...standards for its key interfaces, and has been subjected to successful validation and verification tests to ensure the openness of its key interfaces...widely supported and consensus based standards for its key interfaces, and is subject to validation and verification tests to ensure the openness of its

Advanced transportation system studies technical area 2(TA-2): Heavy lift launch vehicle development. volume 1; Executive summary

NASA Technical Reports Server (NTRS)

McCurry, J.

1995-01-01

The purpose of the TA-2 contract was to provide advanced launch vehicle concept definition and analysis to assist NASA in the identification of future launch vehicle requirements. Contracted analysis activities included vehicle sizing and performance analysis, subsystem concept definition, propulsion subsystem definition (foreign and domestic), ground operations and facilities analysis, and life cycle cost estimation. This document is part of the final report for the TA-2 contract. The final report consists of three volumes: Volume 1 is the Executive Summary, Volume 2 is Technical Results, and Volume 3 is Program Cost Estimates. The document-at-hand, Volume 1, provides a summary description of the technical activities that were performed over the entire contract duration, covering three distinct launch vehicle definition activities: heavy-lift (300,000 pounds injected mass to low Earth orbit) launch vehicles for the First Lunar Outpost (FLO), medium-lift (50,000-80,000 pounds injected mass to low Earth orbit) launch vehicles, and single-stage-to-orbit (SSTO) launch vehicles (25,000 pounds injected mass to a Space Station orbit).

43 CFR 2091.4 - Segregation and opening resulting from the allowance of entries, leases, grants or contracts.

Code of Federal Regulations, 2011 CFR

2011-10-01

... 43 Public Lands: Interior 2 2011-10-01 2011-10-01 false Segregation and opening resulting from the allowance of entries, leases, grants or contracts. 2091.4 Section 2091.4 Public Lands: Interior Regulations... MANAGEMENT (2000) SPECIAL LAWS AND RULES Segregation and Opening of Lands § 2091.4 Segregation and opening...

Effect of anterior capsule contraction on visual function after cataract surgery.

PubMed

Hayashi, Ken; Hayashi, Hideyuki

2007-11-01

To examine the effect of contraction of the anterior capsule opening after cataract surgery on visual acuity and contrast sensitivity. Hayashi Eye Hospital, Fukuoka, Japan. Thirty-two eyes of 32 consecutive patients who showed marked contraction of the anterior capsule opening after implantation of an intraocular lens were recruited. The area of the anterior capsule opening was measured by Scheimpflug videophotography before and after neodymium:YAG (Nd:YAG) laser anterior capsulotomy and was correlated with visual acuity and contrast sensitivity. After Nd:YAG laser anterior capsulotomy, the mean area of the anterior capsule opening increased significantly from 8.2 mm(2) to 18.0 mm(2) (P<.0001). Contrast sensitivity at most visual angles also improved significantly after Nd:YAG anterior capsulotomy, although visual acuity did not. The area of the anterior capsule opening before anterior capsulotomy was correlated significantly with contrast sensitivity but not with visual acuity, whereas there was no correlation between the opening area after anterior capsulotomy and visual acuity or contrast sensitivity. Contraction of the anterior capsule opening after cataract surgery significantly diminished contrast sensitivity in proportion to the opening area but did not markedly worsen visual acuity. Neodymium:YAG laser anterior capsulotomy improved contrast sensitivity.

17 CFR 151.4 - Position limits for Referenced Contracts.

Code of Federal Regulations, 2012 CFR

2012-04-01

... all-months-combined swaps open interest figures within one month, as practicable, after such data is... first 25,000 contracts of average all-months-combined aggregated open interest with a marginal increase... section; (2) Aggregate open interest calculations for non-spot-month position limits for non-legacy...

17 CFR 151.4 - Position limits for Referenced Contracts.

Code of Federal Regulations, 2013 CFR

2013-04-01

... all-months-combined swaps open interest figures within one month, as practicable, after such data is... first 25,000 contracts of average all-months-combined aggregated open interest with a marginal increase... section; (2) Aggregate open interest calculations for non-spot-month position limits for non-legacy...

17 CFR 151.4 - Position limits for Referenced Contracts.

Code of Federal Regulations, 2014 CFR

2014-04-01

... all-months-combined swaps open interest figures within one month, as practicable, after such data is... first 25,000 contracts of average all-months-combined aggregated open interest with a marginal increase... section; (2) Aggregate open interest calculations for non-spot-month position limits for non-legacy...

Mechanisms of boron fiber strengthening by thermal treatment

NASA Technical Reports Server (NTRS)

Dicarlo, J. A.

1979-01-01

The fracture strain for boron on tungsten fibers can be improved by heat treatment under vacuum or argon environments. The mechanical basis for this improvement is thermally-induced axial contraction of the entire fiber, whereby strength-controlling core flaws are compressed and fiber fracture strain increased by the value of the contraction strain. By highly sensitive measurements of fiber density and volume, the physical mechanisms responsible for contraction under both environments was identified as boron atom diffusion out of the fiber sheath. The fiber contracts because the average volume of the resulting microvoid was determined to be only 0.26 + or - 0.09 the average atomic volume of the removed atom. The basic and practical implications of these results are discussed with particular emphasis on the theory, use, and limitations of heat-induced contraction as a simple cost-effective secondary processing method.

Mobile contract services: what you need to know.

PubMed

Inman, M

2000-01-01

With sufficient planning and ongoing attention to detail, the performance of a mobile imaging service provider can exceed expectations and requirements. The relationship can prove to be mutually agreeable and profitable for many years. But, when contracting mobile services, you cannot spend too much time on initial research and detail. Several scenarios present outsourcing or mobile services as an acceptable alternative to purchase or lease: outdated equipment, novel or under-utilized technologies, the need for incrementally added or temporary service. To find suitable providers, check with peer sources in your area for recommendations; look specifically for facilities that are comparable in size and volume to your facility. Expect that larger volume facilities will rate more favorable schedules or pricing. Obtain and check references. Require mobile service providers to adhere to the same state and federal laws, rules and regulations that govern your facility; receive the assurance of compliance in writing if it is not specifically addressed in the contract. JCAHO requires that any contract service provider be governed by the same requirements as the accredited facility. Several other rules or licensing requirements may also pertain to mobile services. A prevailing reason for outsourcing imaging services is high equipment costs that cannot be justified with current volume projections. However, equipment quality should not be compromised; it must meet your needs and be in good repair. The mobile service provider you choose should be an extension of your department; quality standards must exist unilaterally. The set rule for assessing mobile service fees is that there is no set rule. There are many ways to negotiate the fee schedule so that it meets the needs of both parties. An effective marketing campaign lets physicians and patients know what you have available. Work with the mobile service provider to plan an initial announcement or open house. The mobile provider should also have patient education materials for referring physicians and your hospital. Having the mobile technologist meet with the radiologists to discuss written protocols will eliminate misunderstandings concerning expectations of both parties; ongoing communication is vital.

Mechanisms of boron fiber strengthening by thermal treatment

NASA Technical Reports Server (NTRS)

Dicarlo, J. A.

1979-01-01

The fracture strain for boron on tungsten fibers was studied for improvement by heat treatment under vacuum or argon environments. The mechanical basis for this improvement is thermally-induced axial contraction of the entire fiber, whereby strength-controlling core flaws are compressed and fiber fracture strain increased by the value of the contraction strain. By highly sensitive measurements of fiber density and volume, the physical mechanism responsible for contraction under both environments was identified as boron atom diffusion out of the fiber sheath. The fiber contracts because the average volume of the resulting microvoid was determined to be only 0.26 plus or minus 0.09 the average atomic volume of the removed atom. The basic and practical implications of these results are discussed with particular emphasis on the theory, use, and limitations of heat-induced contraction as a simple cost-effective secondary processing method.

Open Questions on the Global Contraction of Mercury

NASA Astrophysics Data System (ADS)

Klimczak, C.; Byrne, P. K.

2018-05-01

Substantial progress has been made on determining the amount, timing, and rate of global contraction on Mercury. But many open questions remain to be answered about the process itself, associated landforms, and interactions with other processes.

Consequences of intravascular lymphatic valve properties: a study of contraction timing in a multi-lymphangion model

PubMed Central

Macaskill, Charlie; Davis, Michael J.; Moore, James E.

2016-01-01

The observed properties of valves in collecting lymphatic vessels include transmural pressure-dependent bias to the open state and hysteresis. The bias may reduce resistance to flow when the vessel is functioning as a conduit. However, lymphatic pumping implies a streamwise increase in mean pressure across each valve, suggesting that the bias is then potentially unhelpful. Lymph pumping by a model of several collecting lymphatic vessel segments (lymphangions) in series, which incorporated these properties, was investigated under conditions of adverse pressure difference while varying the refractory period between active muscular contractions and the inter-lymphangion contraction delay. It was found that many combinations of the timing parameters and the adverse pressure difference led to one or more intermediate valves remaining open instead of switching between open and closed states during repetitive contraction cycles. Cyclic valve switching was reliably indicated if the mean pressure in a lymphangion over a cycle was higher than that in the lymphangion upstream, but either lack of or very brief valve closure could cause mean pressure to be lower downstream. Widely separated combinations of refractory period and delay time were found to produce the greatest flow-rate for a given pressure difference. The efficiency of pumping was always maximized by a long refractory period and lymphangion contraction starting when the contraction of the lymphangion immediately upstream was peaking. By means of an ex vivo experiment, it was verified that intermediate valves in a chain of pumping lymphangions can remain open, while the lymphangions on either side of the open valve continue to execute contractions. PMID:26747501

Acquisition Regulations and Offshore Software Development: Implications for Cybersecurity of DOD Networks

DTIC Science & Technology

2013-02-14

Kessler, “Protection and Protectionism: The Practicalities of Offshore Software Devleopment in Government Procurement,” Public Contract Law Journal, Volume...Protection and Protectionism: The Practicalities of Offshore Software Development In Government Procurement,” Public Contract Law Journal, Volume 38, No. 1

48 CFR 242.1402 - Volume movements within the contiguous United States.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 48 Federal Acquisition Regulations System 3 2010-10-01 2010-10-01 false Volume movements within the contiguous United States. 242.1402 Section 242.1402 Federal Acquisition Regulations System DEFENSE ACQUISITION REGULATIONS SYSTEM, DEPARTMENT OF DEFENSE CONTRACT MANAGEMENT CONTRACT ADMINISTRATION AND AUDIT...

Effect of cold pressor stimulation (4 degrees C) on human masseter muscle haemodynamics during and after sustained isometric contraction.

PubMed

Maekawa, K; Kuboki, T; Yamashita, A; Clark, G T

1999-11-01

The effect of cold pressor (CP) stimulation and sustained isometric contraction on the blood volume of the right masseter muscle was examined in seven healthy males, who performed 1 min of isometric jaw clenching at 50% of their maximum voluntary contraction without, with and again without a 4 degrees C CP stimulation. Total haemoglobin was measured in the masseter before, during and after the contraction task using near-infrared spectroscopy. CP stimulation during the isometric contraction diminished the magnitude of the contraction-induced decrease of blood volume when compared to the trials without CP stimulation. However, in the immediate post-contraction period (while the CP stimulation was still in place), no increase in blood volume above the usual post-contraction hyperaemia was evident. Once the CP stimulation had been removed, there was a clear decrease (faster return to baseline) in the vasodilation occurring in the post-contraction period. This diminished period of vasodilation occurred in spite of the fact that the vascular resistance (blood pressure) and heart rate were still substantially elevated by the CP effect during this same period. These data suggest that the strong CP stimulation produced a biphasic response. First, there was an early-onset strong vasodilation (during CP), which was followed by a period of diminished vasodilation, suggesting that an active, but delayed, vasoconstrictive drive may be induced by the CP stimulus.

48 CFR 14.407-4 - Mistakes after award.

Code of Federal Regulations, 2014 CFR

2014-10-01

... CONTRACTING METHODS AND CONTRACT TYPES SEALED BIDDING Opening of Bids and Award of Contract 14.407-4 Mistakes...) To rescind a contract; (2) To reform a contract (i) to delete the items involved in the mistake or.... (vi) A written request by the contractor to reform or rescind the contract, and copies of all other...

48 CFR 14.407-4 - Mistakes after award.

Code of Federal Regulations, 2012 CFR

2012-10-01

... CONTRACTING METHODS AND CONTRACT TYPES SEALED BIDDING Opening of Bids and Award of Contract 14.407-4 Mistakes...) To rescind a contract; (2) To reform a contract (i) to delete the items involved in the mistake or.... (vi) A written request by the contractor to reform or rescind the contract, and copies of all other...

48 CFR 14.407-4 - Mistakes after award.

Code of Federal Regulations, 2011 CFR

2011-10-01

... CONTRACTING METHODS AND CONTRACT TYPES SEALED BIDDING Opening of Bids and Award of Contract 14.407-4 Mistakes...) To rescind a contract; (2) To reform a contract (i) to delete the items involved in the mistake or.... (vi) A written request by the contractor to reform or rescind the contract, and copies of all other...

48 CFR 14.407-4 - Mistakes after award.

Code of Federal Regulations, 2013 CFR

2013-10-01

... CONTRACTING METHODS AND CONTRACT TYPES SEALED BIDDING Opening of Bids and Award of Contract 14.407-4 Mistakes...) To rescind a contract; (2) To reform a contract (i) to delete the items involved in the mistake or.... (vi) A written request by the contractor to reform or rescind the contract, and copies of all other...

48 CFR 14.407-4 - Mistakes after award.

Code of Federal Regulations, 2010 CFR

2010-10-01

... CONTRACTING METHODS AND CONTRACT TYPES SEALED BIDDING Opening of Bids and Award of Contract 14.407-4 Mistakes...) To rescind a contract; (2) To reform a contract (i) to delete the items involved in the mistake or.... (vi) A written request by the contractor to reform or rescind the contract, and copies of all other...

It Is Chloride Depletion Alkalosis, Not Contraction Alkalosis

PubMed Central

Galla, John H.

2012-01-01

Maintenance of metabolic alkalosis generated by chloride depletion is often attributed to volume contraction. In balance and clearance studies in rats and humans, we showed that chloride repletion in the face of persisting alkali loading, volume contraction, and potassium and sodium depletion completely corrects alkalosis by a renal mechanism. Nephron segment studies strongly suggest the corrective response is orchestrated in the collecting duct, which has several transporters integral to acid-base regulation, the most important of which is pendrin, a luminal Cl/HCO3− exchanger. Chloride depletion alkalosis should replace the notion of contraction alkalosis. PMID:22223876

Factors determining the average atomic volumes in intermetallic compounds.

PubMed

Pauling, L

1987-07-01

In formation of an intermetallic compound from the elementary metals there is usually a contraction in volume. Electron transfer leading to the charge states M(+) and M(-) with increase in valence and decrease in volume explains the more than 2-fold range in contraction for different compounds in the same binary system. In a more thorough analysis, the better packing of atoms of different sizes also needs to be considered.

16 CFR 433.3 - Exemption of sellers taking or receiving open end consumer credit contracts before November 1...

Code of Federal Regulations, 2010 CFR

2010-01-01

... make loans, from time to time, directly from the creditor or indirectly by use of a credit card, check... open end consumer credit contracts before November 1, 1977 from requirements of § 433.2(a). 433.3... CONSUMERS' CLAIMS AND DEFENSES § 433.3 Exemption of sellers taking or receiving open end consumer credit...

36 CFR 223.36 - Volume determination.

Code of Federal Regulations, 2011 CFR

2011-07-01

... other products, or by measuring the trees before cutting. If the contract or permit provides for the determination of volume by tree measurement and the timber has been paid for, the marking or otherwise designating of the tree authorizes cutting and removal. Otherwise no timber cut under any contract shall be...

36 CFR 223.36 - Volume determination.

Code of Federal Regulations, 2014 CFR

2014-07-01

... other products, or by measuring the trees before cutting. If the contract or permit provides for the determination of volume by tree measurement and the timber has been paid for, the marking or otherwise designating of the tree authorizes cutting and removal. Otherwise no timber cut under any contract shall be...

36 CFR 223.36 - Volume determination.

Code of Federal Regulations, 2013 CFR

2013-07-01

... other products, or by measuring the trees before cutting. If the contract or permit provides for the determination of volume by tree measurement and the timber has been paid for, the marking or otherwise designating of the tree authorizes cutting and removal. Otherwise no timber cut under any contract shall be...

36 CFR 223.36 - Volume determination.

Code of Federal Regulations, 2012 CFR

2012-07-01

... other products, or by measuring the trees before cutting. If the contract or permit provides for the determination of volume by tree measurement and the timber has been paid for, the marking or otherwise designating of the tree authorizes cutting and removal. Otherwise no timber cut under any contract shall be...

The effect of rectal distension on bladder function in patients with overactive bladder.

PubMed

Akl, Mohamed N; Jacob, Kristina; Klauschie, Jennifer; Crowell, Michael D; Kho, Rosanne M; Cornella, Jeffrey L

2012-04-01

To investigate the effect of rectal distension on bladder sensation volumes and the number of detrusor contractions in patients with overactive bladder (OAB) symptoms. A prospective randomized study included patients with OAB symptoms. Multichannel urodynamic studies were completed with and without rectal balloon distension. Bladder sensation volumes and detrusor contractions were compared. Twenty-six patients were included in the study. The mean age was 67 years and mean BMI was 28.3 kg/m(2) . Bladder sensation volumes were lower with rectal distention as follows: normal desire to void (139 ml SD, ±114 vs. 197 ml SD ±150, P = 0.01), strong desire to void (260 ml SD ±171 vs. 330 ml SD ±172, P = 0.01), and maximum cystometric capacity (326 ml SD ±183 vs. 403 ml SD ±180, P = 0.0001). There was no difference in the number of detrusor contractions or the bladder volume at which the first detrusor contraction had occurred with and without rectal distension. Rectal distention in patients with OAB symptoms significantly lowered bladder sensation volumes (normal desire, strong desire, and maximal capacity). Copyright © 2012 Wiley Periodicals, Inc.

48 CFR 6.303-1 - Requirements.

Code of Federal Regulations, 2013 CFR

2013-10-01

... COMPETITION REQUIREMENTS Other Than Full and Open Competition 6.303-1 Requirements. (a) A contracting officer... resulting from an unsolicited proposal, or award any other contract without providing for full and open... responsible for providing and certifying as accurate and complete necessary data to support their...

48 CFR 6.303-1 - Requirements.

Code of Federal Regulations, 2014 CFR

2014-10-01

... COMPETITION REQUIREMENTS Other Than Full and Open Competition 6.303-1 Requirements. (a) A contracting officer... resulting from an unsolicited proposal, or award any other contract without providing for full and open... responsible for providing and certifying as accurate and complete necessary data to support their...

48 CFR 14.407-2 - Apparent clerical mistakes.

Code of Federal Regulations, 2010 CFR

2010-10-01

... CONTRACTING METHODS AND CONTRACT TYPES SEALED BIDDING Opening of Bids and Award of Contract 14.407-2 Apparent... contracting officer before award. The contracting officer first shall obtain from the bidder a verification of the bid intended. Examples of apparent mistakes are— (1) Obvious misplacement of a decimal point; (2...

48 CFR 14.407-2 - Apparent clerical mistakes.

Code of Federal Regulations, 2011 CFR

2011-10-01

... CONTRACTING METHODS AND CONTRACT TYPES SEALED BIDDING Opening of Bids and Award of Contract 14.407-2 Apparent... contracting officer before award. The contracting officer first shall obtain from the bidder a verification of the bid intended. Examples of apparent mistakes are— (1) Obvious misplacement of a decimal point; (2...

Compaction bands in shale revealed through digital volume correlation of time-resolved X-ray tomography scans

NASA Astrophysics Data System (ADS)

McBeck, J.; Kobchenko, M.; Hall, S.; Tudisco, E.; Cordonnier, B.; Renard, F.

2017-12-01

Previous studies have identified compaction bands primarily within sandstones, and in fewer instances, within other porous rocks and sediments. Using Digital Volume Correlation (DVC) of X-ray microtomography scans, we find evidence of localized zones of high axial contraction that form tabular structures sub-perpendicular to maximum compression, σ1, in Green River shale. To capture in situ strain localization throughout loading, two shale cores were deformed in the HADES triaxial deformation apparatus installed on the X-ray microtomography beamline ID19 at the European Synchrotron Radiation Facility. In these experiments, we increase σ1 in increments of two MPa, with constant confining pressure (20 MPa), until the sample fails in macroscopic shear. After each stress step, a 3D image of the sample inside the rig is acquired at a voxel resolution of 6.5 μm. The evolution of lower density regions within 3D reconstructions of linear attenuation coefficients reveal the development of fractures that fail with some opening. If a fracture produces negligible dilation, it may remain undetected in image segmentation of the reconstructions. We use the DVC software TomoWarp2 to identify undetected fractures and capture the 3D incremental displacement field between each successive pair of microtomography scans acquired in each experiment. The corresponding strain fields reveal localized bands of high axial contraction that host minimal shear strain, and thus match the kinematic definition of compaction bands. The bands develop sub-perpendicular to σ1 in the two samples in which pre-existing bedding laminations were oriented parallel and perpendicular to σ1. As the shales deform plastically toward macroscopic shear failure, the number of bands and axial contraction within the bands increase, while the spacing between the bands decreases. Compaction band development accelerates the rate of overall axial contraction, increasing the mean axial contraction throughout the sample, and strengthens the shale sufficiently to localize shear faults. These results are critical to robust assessment of deformation patterns in shale rocks in contexts such as nuclear waste storage, hydrocarbon recovery and groundwater access.

Factors determining the average atomic volumes in intermetallic compounds

PubMed Central

Pauling, Linus

1987-01-01

In formation of an intermetallic compound from the elementary metals there is usually a contraction in volume. Electron transfer leading to the charge states M+ and M- with increase in valence and decrease in volume explains the more than 2-fold range in contraction for different compounds in the same binary system. In a more thorough analysis, the better packing of atoms of different sizes also needs to be considered. PMID:16578809

36 CFR 223.45 - Definitions applicable to transfer of purchaser credit.

Code of Federal Regulations, 2010 CFR

2010-07-01

..., DEPARTMENT OF AGRICULTURE SALE AND DISPOSAL OF NATIONAL FOREST SYSTEM TIMBER Timber Sale Contracts Contract... business entities having timber sale contracts on the same National Forest. The term National Forest shall... estimated remaining unscaled (unreported on tree measurement contracts) volumes by species of timber...

75 FR 69715 - New Postal Product

Federal Register 2010, 2011, 2012, 2013, 2014

2010-11-15

... contract for future functional equivalence analyses of the GEPS 3 product. \\1\\ Notice of United States... GEPS contracts, a description of applicable GEPS contracts, formulas for prices, an analysis of the... information and volume commitments, do not alter the contracts' functional equivalency. Id. at 3-4. The Postal...

Identifying Federal Contracting Policy Changes to Improve Government Acquisition of Commercial Space-Launch Capacity

DTIC Science & Technology

1991-09-01

68 iv Page Investigative Question3 .. . . . . . . . . . . . 71 Analysis of Commercial-Like Contracting Benefits . 78 Analysis of Open-ended...Barriers .. ...... 132 Appendix 1: Respondent Comments on Commercial-Like Contracting Benefits ... .. .. .......... 140 Bibliography...69 27. Benefits of Commercial-like Contracting . . . . . 71 28. Well-being Promoted by Commercial-Like Contracting

7 CFR 1753.8 - Contract construction procedures.

Code of Federal Regulations, 2010 CFR

2010-01-01

... of all bids including “Buy American” evaluations, if any, and all other evaluations required by law... Contract construction procedures. (a) Sealed, competitive bidding—(1) Bid opening date. The borrower is responsible for scheduling the bid opening date. If RUS review of P&S is required by § 1753.7, the borrower...

Carbachol-induced volume adaptation in mouse bladder and length adaptation via rhythmic contraction in rabbit detrusor.

PubMed

Speich, John E; Wilson, Cameron W; Almasri, Atheer M; Southern, Jordan B; Klausner, Adam P; Ratz, Paul H

2012-10-01

The length-tension (L-T) relationships in rabbit detrusor smooth muscle (DSM) are similar to those in vascular and airway smooth muscles and exhibit short-term length adaptation characterized by L-T curves that shift along the length axis as a function of activation and strain history. In contrast to skeletal muscle, the length-active tension (L-T(a)) curve for rabbit DSM strips does not have a unique peak tension value with a single ascending and descending limb. Instead, DSM can exhibit multiple ascending and descending limbs, and repeated KCl-induced contractions at a particular muscle length on an ascending or descending limb display increasingly greater tension. In the present study, mouse bladder strips with and without urothelium exhibited KCl-induced and carbachol-induced length adaptation, and the pressure-volume relationship in mouse whole bladder displayed short-term volume adaptation. Finally, prostaglandin-E(2)-induced low-level rhythmic contraction produced length adaptation in rabbit DSM strips. A likely role of length adaptation during bladder filling is to prepare DSM cells to contract efficiently over a broad range of volumes. Mammalian bladders exhibit spontaneous rhythmic contraction (SRC) during the filling phase and SRC is elevated in humans with overactive bladder (OAB). The present data identify a potential physiological role for SRC in bladder adaptation and motivate the investigation of a potential link between short-term volume adaptation and OAB with impaired contractility.

Cost-effectiveness of open versus laparoscopic versus robotic-assisted laparoscopic cystectomy and urinary diversion.

PubMed

Zehnder, Pascal; Gill, Inderbir S

2011-09-01

To provide insight into the recently published cost comparisons in the context of open, laparoscopic, and robotic-assisted laparoscopic radical cystectomy and to demonstrate the complexity of such economic analyses. Most economic evaluations are from a hospital perspective and summarize short-term perioperative therapeutic costs. However, the contributing factors (e.g. study design, included variables, robotic amortization plan, supply contract, surgical volume, surgeons' experience, etc.) vary substantially between the institutions. In addition, a real cost-effective analysis considering cost per quality-adjusted life-year gained is not feasible because of the lack of long-term oncologic and functional outcome data with the robotic procedure. On the basis of a modeled cost analysis using results from published series, robotic-assisted cystectomy was - with few exceptions - found to be more expensive when compared with the open approach. Immediate costs are affected most by operative time, followed by length of hospital stay, robotic supply, case volume, robotic cost, and transfusion rate. Any complication substantially impacts overall costs. Economic cost evaluations are complex analyses influenced by numerous factors that hardly allow an interinstitutional comparison. Robotic-assisted cystectomy is constantly refined with many institutions being somewhere on their learning curve. Transparent reports of oncologic and functional outcome data from centers of expertise applying standardized methods will help to properly analyze the real long-term benefits of robotic surgery and successor technologies and prevent us from becoming slaves of successful marketing strategies.

Evaluation of contract time estimation and contracting procedures for louisiana department of transportation and development construction projects : final report : volume I.

DOT National Transportation Integrated Search

1995-09-11

The purpose of the research was to provide the Louisiana Department of Transportation and Development (LaDOTD) with a systematic approach to the determination of contract time and to explore innovative contracting procedures that may prove beneficial...

17 CFR 21.02 - Special calls for information on open contracts in accounts carried or introduced by futures...

Code of Federal Regulations, 2010 CFR

2010-04-01

... furnish to the Commission the following information concerning accounts of traders owning or controlling... 17 Commodity and Securities Exchanges 1 2010-04-01 2010-04-01 false Special calls for information on open contracts in accounts carried or introduced by futures commission merchants, clearing members...

28 CFR Appendix A to Part 70 - Contract Provisions

Code of Federal Regulations, 2011 CFR

2011-07-01

... NON-PROFIT ORGANIZATIONS Pt. 70, App. A Appendix A to Part 70—Contract Provisions All contracts, awarded by a recipient including small purchases, must contain the following provisions as applicable: 1... purchases of supplies or materials or articles ordinarily available on the open market, or contracts for...

38 CFR Appendix A to Part 49 - Contract Provisions

Code of Federal Regulations, 2011 CFR

2011-07-01

..., HOSPITALS, AND OTHER NON-PROFIT ORGANIZATIONS Pt. 49, App. A Appendix A to Part 49—Contract Provisions All contracts, awarded by a recipient including small purchases, shall contain the following provisions as... purchases of supplies or materials or articles ordinarily available on the open market, or contracts for...

Defense Acquisition Review Journal. Volume 14, Number 2

DTIC Science & Technology

2007-09-01

2007 Vol. 14 No. 2 Learn. Perform. Succeed. Professionalism in the Acquisition Contracting Workforce Have We Gone too Far? John Krieger Contracting...acQuiSition contractinG WorKforce: HAVE WE GONE TOO FAR? John Krieger To professionalize the acquisition contracting workforce, the Department of Defense...featured author for this edition is Professor John Krieger , the Director of the Contracting Center of the Defense Acquisition University’s

78 FR 59076 - Self-Regulatory Organizations; NASDAQ OMX PHLX LLC; Notice of Filing and Immediate Effectiveness...

Federal Register 2010, 2011, 2012, 2013, 2014

2013-09-25

... contracts (Rule 1057) and PHLX FOREX option contracts (Rules 1000C-1009C). Standard expiration contracts... apply only to series of option contracts opened for trading after the effective date of the OCC rule... trading of options in order to change the expiration date for most option contracts to the third Friday of...

78 FR 75420 - Self-Regulatory Organizations; BOX Options Exchange LLC; Notice of Filing and Immediate...

Federal Register 2010, 2011, 2012, 2013, 2014

2013-12-11

... To Amend Interpretive Material To Rule 5050 To Eliminate the Cap on the Number of Additional Series... Rule 5050 (Series of Options Contracts Open for Trading) to eliminate the cap on the number of... Rule 5050 (Series of Options Contracts Open for Trading) to eliminate the cap on the number of...

An Open Door and a Leg Up: Increasing Service-Disabled Veteran-Owned Small Business (SDVOSB) Participation in Defense Contracting Through Simplified Acquisitions (Briefing Charts)

DTIC Science & Technology

2015-05-01

An Open Door and a Leg Up : Increasing Service-Disabled Veteran-Owned Small Business (SDVOSB) Participation in Defense Contracting Through...to 00-00-2015 4. TITLE AND SUBTITLE An Open Door and a Leg Up : Increasing Service-Disabled Veteran-Owned Small Business (SDVOSB) Participation in...4/1999 Rejection of Access to 8(a) Program in HR 1460 Veterans Entrepreneurship and Benefits Improvement Act of 2003 6/5/2003 Unutilized

Ultra-flexible framework breathing in response to dehydration in liskeardite, [(Al,Fe){sub 16}(AsO{sub 4}){sub 9}(OH){sub 21}(H{sub 2}O){sub 11}]·26H{sub 2}O, a natural open-framework compound

DOE Office of Scientific and Technical Information (OSTI.GOV)

Grey, Ian. E., E-mail: Ian.Grey@csiro.au; Brand, Helen E.A.; Rumsey, Michael S.

Dehydration of the natural open-framework compound, liskeardite, [(Al,Fe){sub 16}(AsO{sub 4}){sub 9}(OH){sub 21}(H{sub 2}O){sub 11}]·26H{sub 2}O, is accompanied by a change in the sign of the thermal expansion from positive to negative above room temperature, and at ~100 °C the structure undergoes a dramatic 2D contraction by co-operative rotation of heteropolyhedral columns that constitute the framework walls. Monoclinic liskeardite, I112 with a≈b≈24.7 Å, c ≈7.8 Å and β≈90° is transformed to a tetragonal phase, I-4 with a≈20.6 Å, c ≈7.7 Å. The associated 30% decrease in volume is unprecedented in inorganic microporous compounds. The flexibility of the contraction is related tomore » the double-hinged nature of the column rotations about [001]. Octahedra in adjacent columns are interconnected by corner-sharing with the two pairs of anions forming opposing edges of AsO{sub 4} tetrahedra, so a double-hinged rotation mechanism operates. Thermal analysis and mass spectroscopic results for liskeardite show that the phase transition at ~100 °C is related to removal of the channel water. The tetragonal phase shows exceptionally large NTE behaviour. Over the temperature range 148–178 the NTE along a and b is close to linear with a magnitude of the order of −900×10{sup −6} °C{sup −1}. The contraction along the channel direction is smaller but still appreciable at −200×10{sup −6} °C{sup −1}. - Graphical abstract: Structure of the collapsed liskeardite framework, formed on dehydration above 100 °C. - Highlights: • The thermal expansion of the mineral liskeardite changes + to − above ambient. • Dehydration at 100 °C results in a record reversible 30% volume reduction. • In situ synchrotron XRD has led to a structural model for the dehydrated phase. • Framework breathing flexibility is attributed to a double-hinge rotation mechanism. • The dehydrated phase shows unprecedented -ve expansion for inorganic materials.« less

Defense AR Journal. Volume 14, Number 2, September 2007

DTIC Science & Technology

2007-09-01

2007 Vol. 14 No. 2 Learn. Perform. Succeed. Professionalism in the Acquisition Contracting Workforce Have We Gone too Far? John Krieger Contracting...acQuiSition contractinG WorKforce: HAVE WE GONE TOO FAR? John Krieger To professionalize the acquisition contracting workforce, the Department of...acquisition. Our featured author for this edition is Professor John Krieger , the Director of the Contracting Center of the Defense Acquisition University’s

500 Contractors Receiving the Largest Dollar Volume of Prime Contract Awards for Research, Development, Test, and Evaluation, Fiscal Year 1987.

DTIC Science & Technology

1987-01-01

Headquarters Services Directorate for Information Operations and Reports D) ,( /NT IS lientitra on nn Iber for hIs bh act& r, s (i0 ’F H 7 FOREWORD 500...This report provides information on the 500 contractors that received the largest dollar volume in Department of Defense (DOD) prime contract awards... report presents summary data on the 500 prime contractors receiving the largest dollar volume in Department of Defense (DOD) awards over $25,000 for

Contraction rate, flow modification and bed layering impact on scour at the elliptical guide banks

NASA Astrophysics Data System (ADS)

Gjunsburgs, B.; Jaudzems, G.; Bizane, M.; Bulankina, V.

2017-10-01

Flow contraction by the bridge crossing structures, intakes, embankments, piers, abutments and guide banks leads to general scour and the local scour in the vicinity of the structures. Local scour is depending on flow, river bed and structures parameters and correct understanding of the impact of each parameter can reduce failure possibility of the structures. The paper explores hydraulic contraction, the discharge redistribution between channel and floodplain during the flood, local flow modification and river bed layering on depth, width and volume of scour hole near the elliptical guide banks on low-land rivers. Experiments in a flume, our method for scour calculation and computer modelling results confirm a considerable impact of the contraction rate of the flow, the discharge redistribution between channel and floodplain, the local velocity, backwater and river bed layering on the depth, width, and volume of scour hole in steady and unsteady flow, under clear water condition. With increase of the contraction rate of the flow, the discharge redistribution between channel and floodplain, the local velocity, backwater values, the scour depth increases. At the same contraction rate, but at a different Fr number, the scour depth is different: with increase in the Fr number, the local velocity, backwater, scour depth, width, and volume is increasing. Acceptance of the geometrical contraction of the flow, approach velocity and top sand layer of the river bed for scour depth calculation as accepted now, may be the reason of the structures failure and human life losses.

Contractility of glycerinated Amoeba proteus and Chaos-chaos.

PubMed

Rinaldi, R; Opas, M; Hrebenda, B

1975-05-01

Immediate contact with large volumes of cold 50% (v/v) buffered glycerol preserved typical ameboid shape of Chaos chaos and Amoeba proteus with no visible distortions. These technics allowed determination of the contraction sites in these glycerinated models upon applications of ATP-Ca-Mg-solutions. The ectoplasmic tube was the main site of contraction. Preliminary EM investigations revealed thick and thin filaments, associated with the ectoplasmic tube near the plasma-lemma, which appeared to be the basis for the contractility of the ectoplasmic tube. There was no predominant contraction of the pseudopodial tips or the endoplasm in these models. The changes of volume were as much as 50%, and in some cases were not accompanied by any change in the length of the ameba; however, lengthwise contractions of the ectoplasmic tube in some amebae occurred to as much as 25%. The data substantiate a basic requirement of the ectoplasmic tube contraction theory of ameboid locomotion.

Provider cost analysis supports results-based contracting out of maternal and newborn health services: an evidence-based policy perspective.

PubMed

Hatcher, Peter; Shaikh, Shiraz; Fazli, Hassan; Zaidi, Shehla; Riaz, Atif

2014-11-13

There is dearth of evidence on provider cost of contracted out services particularly for Maternal and Newborn Health (MNH). The evidence base is weak for policy makers to estimate resources required for scaling up contracting. This paper ascertains provider unit costs and expenditure distribution at contracted out government primary health centers to inform the development of optimal resource envelopes for contracting out MNH services. This is a case study of provider costs of MNH services at two government Rural Health Centers (RHCs) contracted out to a non-governmental organization in Pakistan. It reports on four selected Basic Emergency Obstetrical and Newborn Care (BEmONC) services provided in one RHC and six Comprehensive Emergency Obstetrical and Newborn Care (CEmONC) services in the other. Data were collected using staff interviews and record review to compile resource inputs and service volumes, and analyzed using the CORE Plus tool. Unit costs are based on actual costs of MNH services and are calculated for actual volumes in 2011 and for volumes projected to meet need with optimal resource inputs. The unit costs per service for actual 2011 volumes at the BEmONC RHC were antenatal care (ANC) visit USD$ 18.78, normal delivery US$ 84.61, newborn care US$ 16.86 and a postnatal care (PNC) visit US$ 13.86; and at the CEmONC RHC were ANC visit US$ 45.50, Normal Delivery US$ 148.43, assisted delivery US$ 167.43, C-section US$ 183.34, Newborn Care US$ 41.07, and PNC visit US$ 27.34. The unit costs for the projected volumes needed were lower due to optimal utilization of resources. The percentage distribution of expenditures at both RHCs was largest for salaries of technical staff, followed by salaries of administrative staff, and then operating costs, medicines, medical and diagnostic supplies. The unit costs of MNH services at the two contracted out government rural facilities remain higher than is optimal, primarily due to underutilization. Provider cost analysis using standard treatment guideline (STG) based service costing frameworks should be applied across a number of health facilities to calculate the cost of services and guide development of evidence based resource envelopes and performance based contracting.

A multi-scale cardiovascular system model can account for the load-dependence of the end-systolic pressure-volume relationship

PubMed Central

2013-01-01

Background The end-systolic pressure-volume relationship is often considered as a load-independent property of the heart and, for this reason, is widely used as an index of ventricular contractility. However, many criticisms have been expressed against this index and the underlying time-varying elastance theory: first, it does not consider the phenomena underlying contraction and second, the end-systolic pressure volume relationship has been experimentally shown to be load-dependent. Methods In place of the time-varying elastance theory, a microscopic model of sarcomere contraction is used to infer the pressure generated by the contraction of the left ventricle, considered as a spherical assembling of sarcomere units. The left ventricle model is inserted into a closed-loop model of the cardiovascular system. Finally, parameters of the modified cardiovascular system model are identified to reproduce the hemodynamics of a normal dog. Results Experiments that have proven the limitations of the time-varying elastance theory are reproduced with our model: (1) preload reductions, (2) afterload increases, (3) the same experiments with increased ventricular contractility, (4) isovolumic contractions and (5) flow-clamps. All experiments simulated with the model generate different end-systolic pressure-volume relationships, showing that this relationship is actually load-dependent. Furthermore, we show that the results of our simulations are in good agreement with experiments. Conclusions We implemented a multi-scale model of the cardiovascular system, in which ventricular contraction is described by a detailed sarcomere model. Using this model, we successfully reproduced a number of experiments that have shown the failing points of the time-varying elastance theory. In particular, the developed multi-scale model of the cardiovascular system can capture the load-dependence of the end-systolic pressure-volume relationship. PMID:23363818

48 CFR 1452.237-71 - Utilization of Woody Biomass.

Code of Federal Regulations, 2011 CFR

2011-10-01

... timber/vegetative sales contract. Payment under the timber/vegetative sales contract must be at a price... appropriate payment specified in the related timber/vegetative sales contract before removal may be authorized... sales notice and/or prospectus, including volume estimates, appraised value and any appropriate special...

Experimental heat treatment of silcrete implies analogical reasoning in the Middle Stone Age.

PubMed

Wadley, Lyn; Prinsloo, Linda C

2014-05-01

Siliceous rocks that were not heated to high temperatures during their geological formation display improved knapping qualities when they are subjected to controlled heating. Experimental heat treatment of South African silcrete, using open fires of the kind used during the Middle Stone Age, shows that the process needed careful management, notwithstanding recent arguments to the contrary. Silcrete blocks fractured when heated on the surface of open fires or on coal beds, but were heated without mishap when buried in sand below a fire. Three silcrete samples, a control, a block heated underground with maximum temperature between 400 and 500 °C and a block heated in an open fire with maximum temperature between 700 and 800 °C, were analysed with X-ray powder diffraction (XRD), X-ray fluorescence (XRF), optical microscopy, and both Fourier transform infrared (FTIR) and Raman spectroscopy. The results show that the volume expansion during the thermally induced α- to β-quartz phase transformation and the volume contraction during cooling play a major role in the heat treatment of silcrete. Rapid heating or cooling through the phase transformation at 573 °C will cause fracture of the silcrete. Successful heat treatment requires controlling surface fire temperatures in order to obtain the appropriate underground temperatures to stay below the quartz inversion temperature. Heat treatment of rocks is a transformative technology that requires skilled use of fire. This process involves analogical reasoning, which is an attribute of complex cognition. Copyright © 2014 Elsevier Ltd. All rights reserved.

The effect of climbing Mount Everest on spleen contraction and increase in hemoglobin concentration during breath holding and exercise.

PubMed

Engan, Harald K; Lodin-Sundström, Angelica; Schagatay, Fanny; Schagatay, Erika

2014-04-01

Release of stored red blood cells resulting from spleen contraction improves human performance in various hypoxic situations. This study determined spleen volume resulting from two contraction-evoking stimuli: breath holding and exercise before and after altitude acclimatization during a Mount Everest ascent (8848 m). Eight climbers performed the following protocol before and after the climb: 5 min ambient air respiration at 1370 m during rest, 20 min oxygen respiration, 20 min ambient air respiration at 1370 m, three maximal-effort breath holds spaced by 2 min, 10 min ambient air respiration, 5 min of cycling at 100 W, and finally 10 min ambient air respiration. We measured spleen volume by ultrasound and capillary hemoglobin (HB) concentration after each exposure, and heart rate (HR) and arterial oxygen saturation (Sao2) continuously. Mean (SD) baseline spleen volume was unchanged at 213 (101) mL before and 206 (52) mL after the climb. Before the climb, spleen volume was reduced to 184 (83) mL after three breath holds, and after the climb three breath holds resulted in a spleen volume of 132 (26) mL (p=0.032). After exercise, the preclimb spleen volume was 186 (89) mL vs. 112 (389) mL) after the climb (p=0.003). Breath hold duration and cardiovascular responses were unchanged after the climb. We concluded that spleen contraction may be enhanced by altitude acclimatization, probably reflecting both the acclimatization to chronic hypoxic exposure and acute hypoxia during physical work.

48 CFR 214.407-3 - Other mistakes disclosed before award.

Code of Federal Regulations, 2010 CFR

2010-10-01

...) Missile Defense Agency: General Counsel, MDA. (ix) Defense Contract Management Agency: General Counsel... before award. 214.407-3 Section 214.407-3 Federal Acquisition Regulations System DEFENSE ACQUISITION REGULATIONS SYSTEM, DEPARTMENT OF DEFENSE CONTRACTING METHODS AND CONTRACT TYPES SEALED BIDDING Opening of...

48 CFR 1314.409 - Information to bidders.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 48 Federal Acquisition Regulations System 5 2010-10-01 2010-10-01 false Information to bidders. 1314.409 Section 1314.409 Federal Acquisition Regulations System DEPARTMENT OF COMMERCE CONTRACTING METHODS AND CONTRACT TYPES SEALED BIDDING Opening of Bids and Awards of Contracts 1314.409 Information to...

48 CFR 414.409 - Information to bidders.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 48 Federal Acquisition Regulations System 4 2010-10-01 2010-10-01 false Information to bidders. 414.409 Section 414.409 Federal Acquisition Regulations System DEPARTMENT OF AGRICULTURE CONTRACTING METHODS AND CONTRACT TYPES SEALED BIDDING Opening of Bids and Award of Contract 414.409 Information to...

48 CFR 14.409 - Information to bidders.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 48 Federal Acquisition Regulations System 1 2010-10-01 2010-10-01 false Information to bidders. 14.409 Section 14.409 Federal Acquisition Regulations System FEDERAL ACQUISITION REGULATION CONTRACTING METHODS AND CONTRACT TYPES SEALED BIDDING Opening of Bids and Award of Contract 14.409 Information to...

48 CFR 214.407-3 - Other mistakes disclosed before award.

Code of Federal Regulations, 2013 CFR

2013-10-01

...) Missile Defense Agency: General Counsel, MDA. (ix) Defense Contract Management Agency: General Counsel... before award. 214.407-3 Section 214.407-3 Federal Acquisition Regulations System DEFENSE ACQUISITION REGULATIONS SYSTEM, DEPARTMENT OF DEFENSE CONTRACTING METHODS AND CONTRACT TYPES SEALED BIDDING Opening of...

48 CFR 214.407-3 - Other mistakes disclosed before award.

Code of Federal Regulations, 2012 CFR

2012-10-01

...) Missile Defense Agency: General Counsel, MDA. (ix) Defense Contract Management Agency: General Counsel... before award. 214.407-3 Section 214.407-3 Federal Acquisition Regulations System DEFENSE ACQUISITION REGULATIONS SYSTEM, DEPARTMENT OF DEFENSE CONTRACTING METHODS AND CONTRACT TYPES SEALED BIDDING Opening of...

48 CFR 214.407-3 - Other mistakes disclosed before award.

Code of Federal Regulations, 2011 CFR

2011-10-01

...) Missile Defense Agency: General Counsel, MDA. (ix) Defense Contract Management Agency: General Counsel... before award. 214.407-3 Section 214.407-3 Federal Acquisition Regulations System DEFENSE ACQUISITION REGULATIONS SYSTEM, DEPARTMENT OF DEFENSE CONTRACTING METHODS AND CONTRACT TYPES SEALED BIDDING Opening of...

48 CFR 214.407-3 - Other mistakes disclosed before award.

Code of Federal Regulations, 2014 CFR

2014-10-01

...) Missile Defense Agency: General Counsel, MDA. (ix) Defense Contract Management Agency: General Counsel... before award. 214.407-3 Section 214.407-3 Federal Acquisition Regulations System DEFENSE ACQUISITION REGULATIONS SYSTEM, DEPARTMENT OF DEFENSE CONTRACTING METHODS AND CONTRACT TYPES SEALED BIDDING Opening of...

48 CFR 2014.407 - Mistakes in bids.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 48 Federal Acquisition Regulations System 6 2010-10-01 2010-10-01 true Mistakes in bids. 2014.407 Section 2014.407 Federal Acquisition Regulations System NUCLEAR REGULATORY COMMISSION CONTRACTING METHODS AND CONTRACT TYPES SEALED BIDDING Opening of Bids and Award of Contract 2014.407 Mistakes in bids. ...

48 CFR 3414.406 - Mistakes in bids.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 48 Federal Acquisition Regulations System 7 2010-10-01 2010-10-01 false Mistakes in bids. 3414.406 Section 3414.406 Federal Acquisition Regulations System DEPARTMENT OF EDUCATION ACQUISITION REGULATION CONTRACTING METHODS AND CONTRACT TYPES SEALED BIDDING Opening of Bids and Award of Contract 3414.406 Mistakes...

48 CFR 2901.603-70 - Responsibility of other government personnel.

Code of Federal Regulations, 2010 CFR

2010-10-01

... buying process, and execution of the contract rests with the contracting officer. (b) Personnel... obligation. However, DOL personnel who must use the contracting process to accomplish their programs must... and open competition are satisfied to the maximum extent practicable. Sole source purchases may only...

Influence of thermal expansion on shrinkage during photopolymerization of dental resins based on bis-GMA/TEGDMA.

PubMed

Mucci, Veronica; Arenas, Gustavo; Duchowicz, Ricardo; Cook, Wayne D; Vallo, Claudia

2009-01-01

The aim of this study was to assess volume changes that occur during photopolymerization of unfilled dental resins based on bis-GMA-TEGDMA. The resins were activated for visible light polymerization by the addition of camphorquinone (CQ) in combination with dimethylamino ethylmethacrylate (DMAEMA) or ethyl-4-dimethyl aminobenzoate (EDMAB). A fibre-optic sensing method based on a Fizeau-type interferometric scheme was employed for monitoring contraction during photopolymerization. Measurements were carried out on 10mm diameter specimens of different thicknesses (1 and 2mm). The high exothermic nature of the polymerization resulted in volume expansion during the heating, and this effect was more pronounced when the sample thickness increased. Two approaches to assess volume changes due to thermal effects are presented. Due to the difference in thermal expansion coefficients between the rubbery and glassy resins, the increase of volume due to thermal expansion was greater than the decrease in volume due to thermal contraction. As a result, the volume of the vitrified resins was greater than that calculated from polymerization contraction. The observed trends of shrinkage versus sample thickness are explained in terms of light attenuation across the path length during photopolymerization. Results obtained in this research highlight the inherent interlinking of non-isothermal photopolymerization and volumetric changes in bulk polymerizing systems.

Environmental Pollution: Noise Pollution - Sonic Boom. Volume I.

ERIC Educational Resources Information Center

Defense Documentation Center, Alexandria, VA.

The unclassified, annotated bibliography is Volume I of a two-volume set on Noise Pollution - Sonic Boom in a series of scheduled bibliographies on Environmental Pollution. Volume II is Confidential. Corporate author-monitoring agency, subject, title, contract, and report number indexes are included. (Author/JR)

42 CFR 417.426 - Open enrollment requirements.

Code of Federal Regulations, 2013 CFR

2013-10-01

... 42 Public Health 3 2013-10-01 2013-10-01 false Open enrollment requirements. 417.426 Section 417... Open enrollment requirements. (a) Basic requirements. (1) HMOs or CMPs must provide open enrollment for Medicare beneficiaries for at least 30 consecutive days during each contract year. (2) During open...

42 CFR 417.426 - Open enrollment requirements.

Code of Federal Regulations, 2014 CFR

2014-10-01

... 42 Public Health 3 2014-10-01 2014-10-01 false Open enrollment requirements. 417.426 Section 417... Open enrollment requirements. (a) Basic requirements. (1) HMOs or CMPs must provide open enrollment for Medicare beneficiaries for at least 30 consecutive days during each contract year. (2) During open...

42 CFR 417.426 - Open enrollment requirements.

Code of Federal Regulations, 2012 CFR

2012-10-01

... 42 Public Health 3 2012-10-01 2012-10-01 false Open enrollment requirements. 417.426 Section 417... Open enrollment requirements. (a) Basic requirements. (1) HMOs or CMPs must provide open enrollment for Medicare beneficiaries for at least 30 consecutive days during each contract year. (2) During open...

48 CFR 14.408-4 - Economic price adjustment.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 48 Federal Acquisition Regulations System 1 2010-10-01 2010-10-01 false Economic price adjustment... CONTRACTING METHODS AND CONTRACT TYPES SEALED BIDDING Opening of Bids and Award of Contract 14.408-4 Economic price adjustment. (a) Bidder proposes economic price adjustment. (1) When a solicitation does not...

48 CFR 619.811-1 - Sole source.

Code of Federal Regulations, 2011 CFR

2011-10-01

... contracting activity shall include SBA's requirement number on the award document. (4) A single award document... sign the contract as a third party. The 8(a) contractor's signature shall be placed on the award... and open competition. (2) The contracting officer shall insert FAR 52.219-14, Limitations on...

48 CFR 619.811-1 - Sole source.

Code of Federal Regulations, 2010 CFR

2010-10-01

... contracting activity shall include SBA's requirement number on the award document. (4) A single award document... sign the contract as a third party. The 8(a) contractor's signature shall be placed on the award... and open competition. (2) The contracting officer shall insert FAR 52.219-14, Limitations on...

36 CFR Appendix A to Part 1210 - Contract Provisions

Code of Federal Regulations, 2011 CFR

2011-07-01

... EDUCATION, HOSPITALS, AND OTHER NON-PROFIT ORGANIZATIONS Pt. 1210, App. A Appendix A to Part 1210—Contract Provisions All contracts, awarded by a recipient including small purchases, shall contain the following... not apply to the purchases of supplies or materials or articles ordinarily available on the open...

41 CFR Appendix A to Part 105 - 72-Contract Provisions

Code of Federal Regulations, 2011 CFR

2011-01-01

..., HOSPITALS, AND OTHER NON-PROFIT ORGANIZATIONS Pt. 105-72, App. A Appendix A to Part 105-72—Contract Provisions All contracts, awarded by a recipient including small purchases, shall contain the following... not apply to the purchases of supplies or materials or articles ordinarily available on the open...

7 CFR Appendix A to Part 3019 - Contract Provisions

Code of Federal Regulations, 2011 CFR

2011-01-01

... HIGHER EDUCATION, HOSPITALS, AND OTHER NON-PROFIT ORGANIZATIONS Pt. 3019, App. A Appendix A to Part 3019—Contract Provisions All contracts, awarded by a recipient including small purchases, shall contain the... not apply to the purchases of supplies or materials or articles ordinarily available on the open...

34 CFR Appendix A to Part 74 - Contract Provisions

Code of Federal Regulations, 2011 CFR

2011-07-01

... INSTITUTIONS OF HIGHER EDUCATION, HOSPITALS, AND OTHER NON-PROFIT ORGANIZATIONS Pt. 74, App. A Appendix A to Part 74—Contract Provisions All contracts, awarded by a recipient including small purchases, shall... not apply to the purchases of supplies or materials or articles ordinarily available on the open...

22 CFR Appendix A to Part 226 - Contract Provisions

Code of Federal Regulations, 2011 CFR

2011-04-01

...-GOVERNMENTAL ORGANIZATIONS Pt. 226, App. A Appendix A to Part 226—Contract Provisions All contracts, awarded by a recipient including small purchases, shall contain the following provisions as applicable: 1... not apply to the purchases of supplies or materials or articles ordinarily available on the open...

48 CFR 14.408-4 - Economic price adjustment.

Code of Federal Regulations, 2011 CFR

2011-10-01

... 48 Federal Acquisition Regulations System 1 2011-10-01 2011-10-01 false Economic price adjustment... CONTRACTING METHODS AND CONTRACT TYPES SEALED BIDDING Opening of Bids and Award of Contract 14.408-4 Economic price adjustment. (a) Bidder proposes economic price adjustment. (1) When a solicitation does not...

48 CFR 14.408-4 - Economic price adjustment.

Code of Federal Regulations, 2013 CFR

2013-10-01

... 48 Federal Acquisition Regulations System 1 2013-10-01 2013-10-01 false Economic price adjustment... CONTRACTING METHODS AND CONTRACT TYPES SEALED BIDDING Opening of Bids and Award of Contract 14.408-4 Economic price adjustment. (a) Bidder proposes economic price adjustment. (1) When a solicitation does not...

48 CFR 14.408-4 - Economic price adjustment.

Code of Federal Regulations, 2014 CFR

2014-10-01

... 48 Federal Acquisition Regulations System 1 2014-10-01 2014-10-01 false Economic price adjustment... CONTRACTING METHODS AND CONTRACT TYPES SEALED BIDDING Opening of Bids and Award of Contract 14.408-4 Economic price adjustment. (a) Bidder proposes economic price adjustment. (1) When a solicitation does not...

48 CFR 14.408-4 - Economic price adjustment.

Code of Federal Regulations, 2012 CFR

2012-10-01

... 48 Federal Acquisition Regulations System 1 2012-10-01 2012-10-01 false Economic price adjustment... CONTRACTING METHODS AND CONTRACT TYPES SEALED BIDDING Opening of Bids and Award of Contract 14.408-4 Economic price adjustment. (a) Bidder proposes economic price adjustment. (1) When a solicitation does not...

48 CFR 714.406-4 - Disclosure of mistakes after award.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 48 Federal Acquisition Regulations System 5 2010-10-01 2010-10-01 false Disclosure of mistakes after award. 714.406-4 Section 714.406-4 Federal Acquisition Regulations System AGENCY FOR INTERNATIONAL DEVELOPMENT CONTRACTING METHODS AND CONTRACT TYPES SEALED BIDDING Opening of Bids and Award of Contract 714...

48 CFR 714.406-3 - Other mistakes disclosed before award.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 48 Federal Acquisition Regulations System 5 2010-10-01 2010-10-01 false Other mistakes disclosed before award. 714.406-3 Section 714.406-3 Federal Acquisition Regulations System AGENCY FOR INTERNATIONAL DEVELOPMENT CONTRACTING METHODS AND CONTRACT TYPES SEALED BIDDING Opening of Bids and Award of Contract 714...

48 CFR 714.406-3 - Other mistakes disclosed before award.

Code of Federal Regulations, 2011 CFR

2011-10-01

... 48 Federal Acquisition Regulations System 5 2011-10-01 2011-10-01 false Other mistakes disclosed before award. 714.406-3 Section 714.406-3 Federal Acquisition Regulations System AGENCY FOR INTERNATIONAL DEVELOPMENT CONTRACTING METHODS AND CONTRACT TYPES SEALED BIDDING Opening of Bids and Award of Contract 714...

48 CFR 714.406-4 - Disclosure of mistakes after award.

Code of Federal Regulations, 2011 CFR

2011-10-01

... 48 Federal Acquisition Regulations System 5 2011-10-01 2011-10-01 false Disclosure of mistakes after award. 714.406-4 Section 714.406-4 Federal Acquisition Regulations System AGENCY FOR INTERNATIONAL DEVELOPMENT CONTRACTING METHODS AND CONTRACT TYPES SEALED BIDDING Opening of Bids and Award of Contract 714...

A Non-Dimensional Analysis of Cardiovascular Response to Cold Stress. Part I. Identification of the Physical Parameters that Govern the Thermoregulatory Function of the Cardiovascular System.

DTIC Science & Technology

1983-09-01

together with an increased ventricular distensibility , tend to raise the end - 66 - diastolic volume. Again, however, :he inadequace emptying tends to... Distensibility (Sympathetic Increase, Para- sympathetic Decrease); (xi) Atrial contraction (end diastolic volume), (enhanced by sympathetic stimulation...Relationships For Striated Skeletal Muscle; Part III, Mechanics and Energetics of Muscular Contraction," Virginia Polytechnic Institute and State

Advanced Transportation System Studies Technical Area 2 (TA-2) Heavy Lift Launch Vehicle Development Contract. Volume 2; Technical Results

NASA Technical Reports Server (NTRS)

1995-01-01

The purpose of the Advanced Transportation System Studies (ATSS) Technical Area 2 (TA-2) Heavy Lift Launch Vehicle Development contract was to provide advanced launch vehicle concept definition and analysis to assist NASA in the identification of future launch vehicle requirements. Contracted analysis activities included vehicle sizing and performance analysis, subsystem concept definition, propulsion subsystem definition (foreign and domestic), ground operations and facilities analysis, and life cycle cost estimation. This document is Volume 2 of the final report for the contract. It provides documentation of selected technical results from various TA-2 analysis activities, including a detailed narrative description of the SSTO concept assessment results, a user's guide for the associated SSTO sizing tools, an SSTO turnaround assessment report, an executive summary of the ground operations assessments performed during the first year of the contract, a configuration-independent vehicle health management system requirements report, a copy of all major TA-2 contract presentations, a copy of the FLO launch vehicle final report, and references to Pratt & Whitney's TA-2 sponsored final reports regarding the identification of Russian main propulsion technologies.

Influence of vision on masticatory muscles function: surface electromyographic evaluation

PubMed Central

Ciavarella, Domenico; Palazzo, Antonio; De Lillo, Alfredo; Lo Russo, Lucio; Paduano, Sergio; Laino, Luigi; Chimenti, Claudio; Frezza, Federica; Lo Muzio, Lorenzo

2014-01-01

Summary The role of the ocular disorders (OD) in pathogenesis of MMp is still a controversal issue. Ocular arc reflexes (OAR) may involve changes in head and neck posture and generate modifications of contraction resulting in muscle contraction and finally weakness. sEMG tests were performed on 28 patients (13 with masticatory muscles pain and myopia/15 healthy) in rest position with eyes open and eyes closed. Patients group control (healthy patients) showed no significance difference in sEMG record in open/close test. In non healthy patients there were great differences between the sEMG recordings with eyes closed and open. Temporalis and masseters showed a statistical difference of means activation in two tests (temporalis p = 0.0010; masseters = 0.0006). Great difference there was in means muscles activation between open eyes healthy test and non healthy. No difference in close eyes test was evaluated in temporalis and masseters close test in the two groups. The exact causes of MMp are still unknown. The role how ocular disorders (OD) may play an important role in pathogenesis of MMp is still a controversal issue. Ocular arc reflexes (OAR) may involve changes in head and neck posture and generate modifications of contraction resulting in muscle contraction and finally weakness. PMID:25002919

26 CFR 25.2512-6 - Valuation of certain life insurance and annuity contracts; valuation of shares in an open-end...

Code of Federal Regulations, 2013 CFR

2013-04-01

... payments are to be made, the value may be approximated by adding to the interpolated terminal reserve at... Revenue INTERNAL REVENUE SERVICE, DEPARTMENT OF THE TREASURY (CONTINUED) ESTATE AND GIFT TAXES GIFT TAX... and annuity contracts. The value of a life insurance contract or of a contract for the payment of an...

26 CFR 25.2512-6 - Valuation of certain life insurance and annuity contracts; valuation of shares in an open-end...

Code of Federal Regulations, 2012 CFR

2012-04-01

... payments are to be made, the value may be approximated by adding to the interpolated terminal reserve at... Revenue INTERNAL REVENUE SERVICE, DEPARTMENT OF THE TREASURY (CONTINUED) ESTATE AND GIFT TAXES GIFT TAX... and annuity contracts. The value of a life insurance contract or of a contract for the payment of an...

26 CFR 25.2512-6 - Valuation of certain life insurance and annuity contracts; valuation of shares in an open-end...

Code of Federal Regulations, 2014 CFR

2014-04-01

... payments are to be made, the value may be approximated by adding to the interpolated terminal reserve at... Revenue INTERNAL REVENUE SERVICE, DEPARTMENT OF THE TREASURY (CONTINUED) ESTATE AND GIFT TAXES GIFT TAX... and annuity contracts. The value of a life insurance contract or of a contract for the payment of an...

Procurement and Contracting, Transportation & Public Facilities, State of

Science.gov Websites

Calendar Bid Opening Results Contract Award Status AASHTOWare Project Vendor List Contractor Bidding List Contractor Bidding Information Requests for Proposals Professional Services Request for Proposals

Compact cell-centered discretization stencils at fine-coarse block structured grid interfaces

NASA Astrophysics Data System (ADS)

Pletzer, Alexander; Jamroz, Ben; Crockett, Robert; Sides, Scott

2014-03-01

Different strategies for coupling fine-coarse grid patches are explored in the context of the adaptive mesh refinement (AMR) method. We show that applying linear interpolation to fill in the fine grid ghost values can produce a finite volume stencil of comparable accuracy to quadratic interpolation provided the cell volumes are adjusted. The volume of fine cells expands whereas the volume of neighboring coarse cells contracts. The amount by which the cells contract/expand depends on whether the interface is a face, an edge, or a corner. It is shown that quadratic or better interpolation is required when the conductivity is spatially varying, anisotropic, the refinement ratio is other than two, or when the fine-coarse interface is concave.

The influence of injection volume and capsular bag contraction on the refractive power of polymer refilled lenses - a finite element modelling simulation study.

PubMed

Martin, Heiner; Guthoff, Rudolf; Schmitz, Klaus-Peter

2011-09-01

Polymer injection into the capsular bag after phakoemulsification is an interesting and promising approach to lens surgery. Safe clinical application of this technique will require an appropriate estimate of the effect of implantation variables on the lens power. This article details the results of finite element investigations into the effects of the injected polymer volume and capsular bag contraction on the resultant lens power and accommodation amplitude. An axisymmetric finite element model was created from literature sources. Polymer injection and the capsular contraction were simulated, and their effect on the lens power was calculated. The simulations show that overfilling during polymer injection leads to a refractive power increase of the lens. Capsular bag contraction also results in a power increase. The calculated accommodative amplitude of the lens is minimally affected by capsular bag contraction but decreases significantly with increased capsular bag stiffness as a result of fibrosis. © 2010 The Authors. Journal compilation © 2010 Acta Ophthalmol.

12 CFR 214.4 - Agreements with foreign banks, bankers, or States, and participation in foreign accounts.

Code of Federal Regulations, 2010 CFR

2010-01-01

... foreign accounts. (a) No Federal Reserve Bank shall enter into any agreement, contract, or understanding... foreign State, or has entered into any agreement, contract, or understanding with reference to opening or... may participate in such account, or in such agreement, contract, or understanding, and in operations...

10 CFR Appendix A to Subpart B of... - Contract Provisions

Code of Federal Regulations, 2011 CFR

2011-01-01

..., Hospitals, and Other Nonprofit Organizations Pt. 600, Subpt. B, App. A Appendix A to Subpart B of Part 600—Contract Provisions All contracts, awarded by a recipient including small purchases, shall contain the... not apply to the purchases of supplies or materials or articles ordinarily available on the open...

Review and analysis of ASAP enforcement efforts, volume 4

DOT National Transportation Integrated Search

1975-08-01

This Final Report recapitulates and summarizes the work of a contract on Review and Analysis of ASAP Enforcement Effort. The major sections of the report are contained in four volumes. Volume 1, Methods for Recording the Behavior of Drinking Drivers,...

Review and analysis of ASAP enforcement efforts, volume 3

DOT National Transportation Integrated Search

1975-08-01

This Final Report recapitulates and summarizes the work of a contract on Review and Analysis of ASAP Enforcement Effort. The major sections of the report are contained in four volumes. Volume 1, Methods for Recording the Behavior of Drinking Drivers,...

Review and analysis of ASAP enforcement efforts, volume 1

DOT National Transportation Integrated Search

1975-08-01

This Final Report recapitulates and summarizes the work of a contract on : Review and Analysis of ASAP Enforcement Effort. The major sections of the report : are contained in four volumes. : Volume 1, Methods for Recording the Behavior of Drinking Dr...

Review and analysis of ASAP enforcement efforts, volume 2

DOT National Transportation Integrated Search

1975-08-01

This Final Report recapitulates and summarizes the work of a contract on Review and Analysis of ASAP Enforcement Effort. The major sections of the report are contained in four volumes. Volume 1, Methods for Recording the Behavior of Drinking Drivers,...

Contracting for Success: Developing Geothermal Resources on Military Lands. Volume 2. Appendices C through F

DTIC Science & Technology

1993-10-01

continues to consider that Sound value compensation, in the detrimental liability for payment of the change to fair value compensation in abstract...in concession the new standard contract generally contract. Depending on the buildings. The fair value compensation provides for a redefined " fair ...standard contract also changes book concessioner sound value concession operators is of benefit to value to fair value in most compensation. For example

24 CFR 203.270 - Open-end insurance charges.

Code of Federal Regulations, 2010 CFR

2010-04-01

... 24 Housing and Urban Development 2 2010-04-01 2010-04-01 false Open-end insurance charges. 203.270... SINGLE FAMILY MORTGAGE INSURANCE Contract Rights and Obligations Open-End Insurance Charges-All Mortgages § 203.270 Open-end insurance charges. (a) Required charge. In the case of an insured open-end advance...

24 CFR 203.270 - Open-end insurance charges.

Code of Federal Regulations, 2014 CFR

2014-04-01

... 24 Housing and Urban Development 2 2014-04-01 2014-04-01 false Open-end insurance charges. 203.270... SINGLE FAMILY MORTGAGE INSURANCE Contract Rights and Obligations Open-End Insurance Charges-All Mortgages § 203.270 Open-end insurance charges. (a) Required charge. In the case of an insured open-end advance...

24 CFR 203.270 - Open-end insurance charges.

Code of Federal Regulations, 2011 CFR

2011-04-01

... 24 Housing and Urban Development 2 2011-04-01 2011-04-01 false Open-end insurance charges. 203.270... SINGLE FAMILY MORTGAGE INSURANCE Contract Rights and Obligations Open-End Insurance Charges-All Mortgages § 203.270 Open-end insurance charges. (a) Required charge. In the case of an insured open-end advance...

24 CFR 203.270 - Open-end insurance charges.

Code of Federal Regulations, 2012 CFR

2012-04-01

... 24 Housing and Urban Development 2 2012-04-01 2012-04-01 false Open-end insurance charges. 203.270... SINGLE FAMILY MORTGAGE INSURANCE Contract Rights and Obligations Open-End Insurance Charges-All Mortgages § 203.270 Open-end insurance charges. (a) Required charge. In the case of an insured open-end advance...

24 CFR 203.270 - Open-end insurance charges.

Code of Federal Regulations, 2013 CFR

2013-04-01

... 24 Housing and Urban Development 2 2013-04-01 2013-04-01 false Open-end insurance charges. 203.270... SINGLE FAMILY MORTGAGE INSURANCE Contract Rights and Obligations Open-End Insurance Charges-All Mortgages § 203.270 Open-end insurance charges. (a) Required charge. In the case of an insured open-end advance...

Thermally promoted evolution of open-volume defects and Cu precipitates in the deformed FeCu alloys

NASA Astrophysics Data System (ADS)

Jin, Shuoxue; Cao, Xingzhong; Cheng, Guodong; Lian, Xiangyu; Zhu, Te; Zhang, Peng; Yu, Runsheng; Wang, Baoyi

2018-04-01

We have studied the effect of isothermal annealing on the evolution of the open-volume defect and the Cu precipitate in deformed Fe0.15Cu, Fe0.3Cu and Fe0.6Cu alloys. Using the coincidence Doppler broadening, positron annihilation lifetime and the S-W couples, the evolution of local electronic circumstance around the annihilation sites, open-volume defects and interaction between open-volume defects and Cu precipitates were measured as a function of the isothermal annealing temperatures. Cold rolling deformation induced an obvious increment in S parameters due to the formation of open-volume defects. Annealing not only resulted in gradual recovery of open-volume defects and Cu thermal precipitation, but also promoted the combination and interaction between defects and Cu precipitates. The interaction between open-volume defects and Cu precipitates was revealed clearly by the view point of S-W relationship. The S-W interaction for the different CumVn complexes was also calculated theoretically by MIKA-Doppler, which supports our experimental observations qualitatively. The results indicate that open-volume defects were formed first after cold rolling, followed by the Cu precipitation and recovery of open-volume defects, Cu precipitates recovered at the end. It is interesting that the trajectory of (S, W) points with increasing annealing temperature formed a similar closed "Parallelogram" shape. It is benefit for revealing the behavior of Cu thermal precipitation and their evolution in various Cu-bearing steels under thermal treatment. In addition, we also investigated the Cu content effect on the Cu precipitation in FeCu alloys, and the Cu precipitate phenomenon was enhanced in higher Cu content alloys.

42 CFR 417.426 - Open enrollment requirements.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 42 Public Health 3 2010-10-01 2010-10-01 false Open enrollment requirements. 417.426 Section 417... PREPAYMENT PLANS Enrollment, Entitlement, and Disenrollment under Medicare Contract § 417.426 Open enrollment requirements. (a) Basic requirements. (1) HMOs or CMPs must provide open enrollment for Medicare beneficiaries...

42 CFR 417.426 - Open enrollment requirements.

Code of Federal Regulations, 2011 CFR

2011-10-01

... 42 Public Health 3 2011-10-01 2011-10-01 false Open enrollment requirements. 417.426 Section 417... PREPAYMENT PLANS Enrollment, Entitlement, and Disenrollment under Medicare Contract § 417.426 Open enrollment requirements. (a) Basic requirements. (1) HMOs or CMPs must provide open enrollment for Medicare beneficiaries...

48 CFR 47.207-11 - Volume movements within the contiguous United States.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 48 Federal Acquisition Regulations System 1 2010-10-01 2010-10-01 false Volume movements within... Transportation-Related Services 47.207-11 Volume movements within the contiguous United States. (a) For purposes of contract administration, a volume movement is— (1) In DoD, the aggregate of freight shipments...

48 CFR 6.301 - Policy.

Code of Federal Regulations, 2010 CFR

2010-10-01

... without providing for full and open competition or full and open competition after exclusion of sources is... COMPETITION REQUIREMENTS Other Than Full and Open Competition 6.301 Policy. (a) 41 U.S.C. 253(c) and 10 U.S.C. 2304(c) each authorize, under certain conditions, contracting without providing for full and open...

A Study of the Effectiveness of the Army’s National Advertising Expenditures. Volume 1. Executive Summary.

DTIC Science & Technology

1981-08-31

AD-A39 993 A STUDY OF THE EFFECTIVENESS OF THE RRMY’S NATIONAL 1/1 ADVERTISING EXPENDITURES VOLUME I EXECUTIVE SUNMARY(U) AYER (N W) INC NEW YORK 31... Advertising Expenditures ExecLtwe Summary N W AYER INCORPORATED :: ,AUGUST1981 DTIC OkEECTE Approved for Public Release 12 I’ Distribution Unlimited A...reverse side it necesary &-d Identify by block number) ADVERTISING , ACCESSIONS,* CONTRACTS, ACCESSIONS AS CONTRACTED, ARMY, RECRUITING, EFECTIVENESS

Activated Monocytes Enhance Platelet-Driven Contraction of Blood Clots via Tissue Factor Expression.

PubMed

Peshkova, Alina D; Le Minh, Giang; Tutwiler, Valerie; Andrianova, Izabella A; Weisel, John W; Litvinov, Rustem I

2017-07-11

Platelet-driven reduction in blood clot volume (clot contraction or retraction) has been implicated to play a role in hemostasis and thrombosis. Although these processes are often linked with inflammation, the role of inflammatory cells in contraction of blood clots and thrombi has not been investigated. The aim of this work was to study the influence of activated monocytes on clot contraction. The effects of monocytes were evaluated using a quantitative optical tracking methodology to follow volume changes in a blood clot formed in vitro. When a physiologically relevant number of isolated human monocytes pre-activated with phorbol-12-myristate-13-acetate (PMA) were added back into whole blood, the extent and rate of clot contraction were increased compared to addition of non-activated cells. Inhibition of tissue factor expression or its inactivation on the surface of PMA-treated monocytes reduced the extent and rate of clot contraction back to control levels with non-activated monocytes. On the contrary, addition of tissue factor enhanced clot contraction, mimicking the effects of tissue factor expressed on the activated monocytes. These data suggest that the inflammatory cells through their expression of tissue factor can directly affect hemostasis and thrombosis by modulating the size and density of intra- and extravascular clots and thrombi.

48 CFR 14.408-6 - Equal low bids.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 48 Federal Acquisition Regulations System 1 2010-10-01 2010-10-01 false Equal low bids. 14.408-6... AND CONTRACT TYPES SEALED BIDDING Opening of Bids and Award of Contract 14.408-6 Equal low bids. (a) Contracts shall be awarded in the following order of priority when two or more low bids are equal in all...

Injection-salting of pre rigor fillets of Atlantic salmon (Salmo salar).

PubMed

Birkeland, Sveinung; Akse, Leif; Joensen, Sjurdur; Tobiassen, Torbjørn; Skåra, Torstein

2007-01-01

The effects of temperature (-1, 4, and 10 degrees C), brine concentration (12% and 25% NaCl), injection volumes, and needle densities were investigated on fillet weight gain (%), salt content (%), fillet contraction (%), and muscle gaping in pre rigor brine-injected fillets of Atlantic salmon (Salmo salar). Increased brine concentration (12% to 25%) significantly increased the initial (< 5 min after injection) and final contraction (24 h after injection) of pre rigor fillets. Increased brine concentration significantly reduced weight gain and increased salt content but had no significant effect on muscle gaping. The temperatures tested did not significantly affect weight gain, fillet contraction, or gaping score. Significant regressions (P < 0.01) between the injection volume and weight gain (range: 2.5% to 15.5%) and salt content (range: 1.7% to 6.5%) were observed for injections of pre rigor fillets. Double injections significantly increased the weight gain and salt content compared to single injections. Initial fillet contraction measured 30 min after brine injection increased significantly (P < 0.01) with increasing brine injection volume but no significant difference in the fillet contraction was observed 12 h after brine injection (range: 7.9% to 8.9%). Brine-injected post rigor control fillets obtained higher weight gain, higher salt content, more muscle gaping, and significantly lower fillet contraction compared to the pre rigor injected fillets. Injection-salting is an applicable technology as a means to obtain satisfactory salt contents and homogenously distribute the salt into the muscle of pre rigor fillets of Atlantic salmon before further processing steps such as drying and smoking.

75 FR 39301 - Self-Regulatory Organizations; Notice of Filing and Immediate Effectiveness of Proposed Rule...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-07-08

...,000 contracts. Payments would be made at the stated rate for each tier for those contracts that fall... increasing the per contract rate on the Tier II and Tier III levels. The Exchange still continues to afford the members [sic] organizations who transact volume in Tier I a benefit as well. Amending the...

Contraction of Blood Clots Is Impaired in Acute Ischemic Stroke.

PubMed

Tutwiler, Valerie; Peshkova, Alina D; Andrianova, Izabella A; Khasanova, Dina R; Weisel, John W; Litvinov, Rustem I

2017-02-01

Obstructive thrombi or thrombotic emboli are the pathogenic basis of ischemic stroke. In vitro blood clots and in vivo thrombi can undergo platelet-driven contraction (retraction), resulting in volume shrinkage. Clot contraction can potentially reduce vessel occlusion and improve blood flow past emboli or thrombi. The aim of this work was to examine a potential pathogenic role of clot contraction in ischemic stroke. We used a novel automated method that enabled us to quantify time of initiation and extent and rate of clot contraction in vitro. The main finding is that clot contraction from the blood of stroke patients was reduced compared with healthy subjects. Reduced clot contraction correlated with a lower platelet count and their dysfunction, higher levels of fibrinogen and hematocrit, leukocytosis, and other changes in blood composition that may affect platelet function and properties of blood clots. Platelets from stroke patents were spontaneously activated and displayed reduced responsiveness to additional stimulation. Clinical correlations with respect to severity and stroke pathogenesis suggest that the impaired clot contraction has the potential to be a pathogenic factor in ischemic stroke. The changeable ability of clots and thrombi to shrink in volume may be a novel unappreciated mechanism that aggravates or alleviates the course and outcomes of ischemic stroke. The clinical importance of clot or thrombus transformations in vivo and the diagnostic and prognostic value of this blood test for clot contraction need further exploration. © 2016 American Heart Association, Inc.

Contraction of Blood Clots is Impaired in Acute Ischemic Stroke

PubMed Central

Tutwiler, Valerie; Peshkova, Alina D.; Andrianova, Izabella A.; Khasanova, Dina R.; Weisel, John W.; Litvinov, Rustem I.

2016-01-01

Objective Obstructive thrombi or thrombotic emboli are the pathogenic basis of ischemic stroke. In vitro blood clots and in vivo thrombi can undergo platelet-driven contraction (retraction), resulting in volume shrinkage. Clot contraction can potentially reduce vessel occlusion and improve blood flow past emboli or thrombi. The aim of this work was to examine a potential pathogenic role of clot contraction in ischemic stroke. Approach and Results We employed a novel automated method that enabled us to quantify time of initiation, extent and rate of clot contraction in vitro. The main finding is clot contraction from the blood of stroke patients was reduced compared to healthy subjects. Reduced clot contraction correlated with a lower platelet count and their dysfunction, higher levels of fibrinogen and hematocrit, leukocytosis and other changes in blood composition that may affect platelet function and properties of blood clots. Platelets from stroke patents were spontaneously activated and displayed reduced responsiveness to additional stimulation. Clinical correlations with respect to severity and stroke etiology suggest that the impaired clot contraction has the potential to be a pathogenic factor in ischemic stroke. Conclusions The changeable ability of clots and thrombi to shrink in volume may be a novel unappreciated mechanism that aggravates or alleviates the course and outcomes of ischemic stroke. The clinical importance of clot or thrombus transformations in vivo and the diagnostic and prognostic value of this blood test for clot contraction needs further exploration. PMID:27908894

Functional characterization of contractile vacuole isolated from Amoeba proteus.

PubMed

Nishihara, Eri; Shimmen, Teruo; Sonobe, Seiji

2004-12-01

Contractile vacuoles (CVs) released from cells of Amoeba proteus were used to analyze its function in vitro. When CV was transferred to a hypertonic medium, its volume decreased within 10 sec. When it was subsequently returned to its original medium, it quickly started swelling. However, it ruptured before recovering its initial volume. These results suggested that the CV membrane is semi-permeable and that the fluid is collected by the osmotic gradient in vivo. The water permeability of membrane of isolated CV was calculated from the rate of osmotic volume change to be 0.94 microm/sec . OsM. This high value suggested that CV membrane is equipped with water channel. CV contracted (or burst) quickly upon addition of 1 mM ATP. Contraction was induced by ATP, but not by other nucleotides, GTP, ITP, ADP, or the analogues of ATP, AMP-PNP and ATPgammaS. It was suggested that the contraction of isolated CV was caused by increase in the tension of its membrane by ATP.

An open-source model and solution method to predict co-contraction in the finger.

PubMed

MacIntosh, Alexander R; Keir, Peter J

2017-10-01

A novel open-source biomechanical model of the index finger with an electromyography (EMG)-constrained static optimization solution method are developed with the goal of improving co-contraction estimates and providing means to assess tendon tension distribution through the finger. The Intrinsic model has four degrees of freedom and seven muscles (with a 14 component extensor mechanism). A novel plugin developed for the OpenSim modelling software applied the EMG-constrained static optimization solution method. Ten participants performed static pressing in three finger postures and five dynamic free motion tasks. Index finger 3D kinematics, force (5, 15, 30 N), and EMG (4 extrinsic muscles and first dorsal interosseous) were used in the analysis. The Intrinsic model predicted co-contraction increased by 29% during static pressing over the existing model. Further, tendon tension distribution patterns and forces, known to be essential to produce finger action, were determined by the model across all postures. The Intrinsic model and custom solution method improved co-contraction estimates to facilitate force propagation through the finger. These tools improve our interpretation of loads in the finger to develop better rehabilitation and workplace injury risk reduction strategies.

Robot-assisted versus open radical prostatectomy: the differential effect of regionalization, procedure volume and operative approach.

PubMed

Sammon, Jesse D; Karakiewicz, Pierre I; Sun, Maxine; Sukumar, Shyam; Ravi, Praful; Ghani, Khurshid R; Bianchi, Marco; Peabody, James O; Shariat, Shahrokh F; Perrotte, Paul; Hu, Jim C; Menon, Mani; Trinh, Quoc-Dien

2013-04-01

The use of robot-assisted radical prostatectomy has increased rapidly despite the absence of randomized, controlled trials showing the superiority of this approach. While recent studies suggest an advantage for perioperative complication rates, they fail to account for the volume-outcome relationship. We compared perioperative outcomes after robot-assisted and open radical prostatectomy, while considering the impact of this established relationship. Using the NIS (Nationwide Inpatient Sample), we abstracted data on patients treated with radical prostatectomy in 2009. Univariable and multivariable logistic regression analyses were done to compare the rates of blood transfusion, intraoperative and postoperative complications, prolonged length of stay, increased hospital charges and mortality between robot-assisted and open radical prostatectomy overall and across volume quartiles. An estimated 77,616 men underwent radical prostatectomy, including a robot-assisted and an open procedure in 63.9% and 36.1%, respectively. Low volume centers averaged 26.2 robot-assisted and 5.2 open cases, while very high volume centers averaged 578.8 robot-assisted and 150.2 open cases. Overall, patients treated with the robot-assisted procedure experienced a lower rate of adverse outcomes than those treated with the open procedure for all measured categories. Across equivalent volume quartiles robot-assisted radical prostatectomy outcomes were generally favorable. However, the open procedure at high volume centers resulted in a lower postoperative complication rate (OR 0.59, 95% CI 0.46-0.75), elevated hospital charges (OR 0.75, 95% CI 0.64-0.87) and a comparable blood transfusion rate (OR 1.38, 95% CI 0.93-2.02) relative to the robot-assisted procedure at low volume centers. Regionalization has occurred to a greater extent for robot-assisted than for open radical prostatectomy with an associated benefit in overall outcomes. Nonetheless, low volume institutions experienced inferior outcomes relative to the highest volume centers irrespective of approach. These findings demonstrate the importance of accounting for hospital volume when examining the benefit of a surgical technique. Copyright © 2013 American Urological Association Education and Research, Inc. Published by Elsevier Inc. All rights reserved.

Decrease in coronary vascular volume in systole augments cardiac contraction.

PubMed

Willemsen, M J; Duncker, D J; Krams, R; Dijkman, M A; Lamberts, R R; Sipkema, P; Westerhof, N

2001-08-01

Coronary arterial inflow is impeded and venous outflow is increased as a result of the decrease in coronary vascular volume due to cardiac contraction. We evaluated whether cardiac contraction is influenced by interfering with the changes of the coronary vascular volume over the heart cycle. Length-tension relationships were determined in Tyrode-perfused rat papillary muscle and when coronary vascular volume changes were partly inhibited by filling it with congealed gelatin or perfusing it with a high viscosity dextran buffer. Also, myocyte thickening during contraction was reduced by placing a silicon tube around the muscle. Increasing perfusion pressure from 8 to 80 cmH2O, increased developed tension by approximately 40%. When compared with the low perfusion state, developed tension of the gelatin-filled vasculature was reduced to 43 +/- 6% at the muscle length where the muscle generates the largest developed tension (n = 5, means +/- SE). Dextran reduced developed tension to 73 +/- 6% (n = 6). The silicon tube, in low perfusion state, reduced the developed tension to 83 +/- 7% (n = 4) of control. Time-control and oxygen-lowering experiments show that the findings are based on mechanical effects. Thus interventions to prevent myocyte thickening reduce developed tension. We hypothesize that when myocyte thickening is prevented, intracellular pressure increases and counteracts the force produced by the contractile apparatus. We conclude that emptying of the coronary vasculature serves a physiological purpose by facilitating cardiomyocyte thickening thereby augmenting force development.

26 CFR 20.2031-8 - Valuation of certain life insurance and annuity contracts; valuation of shares in an open-end...

Code of Federal Regulations, 2012 CFR

2012-04-01

..., the value may be approximated by adding to the interpolated terminal reserve at the date of the... Revenue INTERNAL REVENUE SERVICE, DEPARTMENT OF THE TREASURY (CONTINUED) ESTATE AND GIFT TAXES ESTATE TAX... certain life insurance and annuity contracts. (1) The value of a contract for the payment of an annuity...

26 CFR 20.2031-8 - Valuation of certain life insurance and annuity contracts; valuation of shares in an open-end...

Code of Federal Regulations, 2013 CFR

2013-04-01

..., the value may be approximated by adding to the interpolated terminal reserve at the date of the... Revenue INTERNAL REVENUE SERVICE, DEPARTMENT OF THE TREASURY (CONTINUED) ESTATE AND GIFT TAXES ESTATE TAX... certain life insurance and annuity contracts. (1) The value of a contract for the payment of an annuity...

Improving observational study estimates of treatment effects using joint modeling of selection effects and outcomes: the case of AAA repair.

PubMed

O'Malley, A James; Cotterill, Philip; Schermerhorn, Marc L; Landon, Bruce E

2011-12-01

When 2 treatment approaches are available, there are likely to be unmeasured confounders that influence choice of procedure, which complicates estimation of the causal effect of treatment on outcomes using observational data. To estimate the effect of endovascular (endo) versus open surgical (open) repair, including possible modification by institutional volume, on survival after treatment for abdominal aortic aneurysm, accounting for observed and unobserved confounding variables. Observational study of data from the Medicare program using a joint model of treatment selection and survival given treatment to estimate the effects of type of surgery and institutional volume on survival. We studied 61,414 eligible repairs of intact abdominal aortic aneurysms during 2001 to 2004. The outcome, perioperative death, is defined as in-hospital death or death within 30 days of operation. The key predictors are use of endo, transformed endo and open volume, and endo-volume interactions. There is strong evidence of nonrandom selection of treatment with potential confounding variables including institutional volume and procedure date, variables not typically adjusted for in clinical trials. The best fitting model included heterogeneous transformations of endo volume for endo cases and open volume for open cases as predictors. Consistent with our hypothesis, accounting for unmeasured selection reduced the mortality benefit of endo. The effect of endo versus open surgery varies nonlinearly with endo and open volume. Accounting for institutional experience and unmeasured selection enables better decision-making by physicians making treatment referrals, investigators evaluating treatments, and policy makers.

DCAA Contract Audit Manual. Volume 1, Chapters 1 - 11

DTIC Science & Technology

1995-01-01

Office de Carvalho, Jenny Alexandria Branch Office Davids, Steve J. Melbourne Branch Office Dean, Clay Defense Contract Audit Institute Desert Valley...Justice DOL Department of Labor DOT Department of Transportation DPRO Defense Plant Representative Offices EAC Estimate At Completion (Cost) EDP...in the Department of De - vide accounting and financial advisory fense- services regarding contracts and subcon- tracts to all Department of Defense

Flight set 360L007 (STS-33) insulation component. Volume 3: Final release

NASA Technical Reports Server (NTRS)

Hicken, Steve

1990-01-01

Volume 3 of this postfire report deals with the insulation component of the RSRM. The report is released twice for each flight set. The interim release contract date is on or before 60 days after the last field joint or nozzle to case joint is disassembled at KSC and contain the results of the KSC visual evaluation. The data contained in Volume 3 interim release supersedes the insulation data presented in the KSC 10 day report. The final release contract data is on or before 60 days after the last factory joint is disassembled at the Clearfield H-7 facility and contains the results of all visual evaluations and a thermal safety factor analysis. The data contained in the Volume 3 final release supersedes the interim release and the insulation data presented in the Clearfield 10 day report.

17 CFR 190.04 - Operation of the debtor's estate-general.

Code of Federal Regulations, 2011 CFR

2011-04-01

... such unmatched contracts, using the average of the opening price and the settlement price of contracts... (1976 & Supp. V. 1981 and Pub. L. 97-444); secs. 761-766 of the Bankruptcy Reform Act of 1978, as...

17 CFR 190.04 - Operation of the debtor's estate-general.

Code of Federal Regulations, 2012 CFR

2012-04-01

... such unmatched contracts, using the average of the opening price and the settlement price of contracts... (1976 & Supp. V. 1981 and Pub. L. 97-444); secs. 761-766 of the Bankruptcy Reform Act of 1978, as...

Sensory-motor responses to mechanical stimulation of the esophagus after sensitization with acid.

PubMed

Drewes, Asbjørn-Mohr; Reddy, Hariprasad; Staahl, Camilla; Pedersen, Jan; Funch-Jensen, Peter; Arendt-Nielsen, Lars; Gregersen, Hans

2005-07-28

Sensitization most likely plays an important role in chronic pain disorders, and such sensitization can be mimicked by experimental acid perfusion of the esophagus. The current study systematically investigated the sensory and motor responses of the esophagus to controlled mechanical stimuli before and after sensitization. Thirty healthy subjects were included. Distension of the distal esophagus with a balloon was performed before and after perfusion with 0.1 mol/L hydrochloric acid for 30 min. An impedance planimetry system was used to measure cross-sectional area, volume, pressure, and tension during the distensions. A new model allowed evaluation of the phasic contractions by the tension during contractions as a function of the initial muscle length before the contraction (comparable to the Frank-Starling law for the heart). Length-tension diagrams were used to evaluate the muscle tone before and after relaxation of the smooth muscle with butylscopolamine. The sensitization resulted in allodynia and hyperalgesia to the distension volumes, and the degree of sensitization was related to the infused volume of acid. Furthermore, a nearly 50% increase in the evoked referred pain was seen after sensitization. The mechanical analysis demonstrated hyper-reactivity of the esophagus following acid perfusion, with an increased number and force of the phasic contractions, but the muscle tone did not change. Acid perfusion of the esophagus sensitizes the sensory pathways and facilitates secondary contractions. The new model can be used to study abnormal sensory-motor mechanisms in visceral organs.

Sensory-motor responses to mechanical stimulation of the esophagus after sensitization with acid

PubMed Central

Drewes, Asbjorn Mohr; Reddy, Hariprasad; Staahl, Camilla; Pedersen, Jan; Funch-Jensen, Peter; Arendt-Nielsen, Lars; Gregersen, Hans

2005-01-01

AIM: Sensitization most likely plays an important role in chronic pain disorders, and such sensitization can be mimicked by experimental acid perfusion of the esophagus. The current study systematically investigated the sensory and motor responses of the esophagus to controlled mechanical stimuli before and after sensitization. METHODS: Thirty healthy subjects were included. Distension of the distal esophagus with a balloon was performed before and after perfusion with 0.1 mol/L hydrochloric acid for 30 min. An impedance planimetry system was used to measure cross-sectional area, volume, pressure, and tension during the distensions. A new model allowed evaluation of the phasic contractions by the tension during contractions as a function of the initial muscle length before the contraction (comparable to the Frank-Starling law for the heart). Length-tension diagrams were used to evaluate the muscle tone before and after relaxation of the smooth muscle with butylscopolamine. RESULTS: The sensitization resulted in allodynia and hyperalgesia to the distension volumes, and the degree of sensitization was related to the infused volume of acid. Furthermore, a nearly 50% increase in the evoked referred pain was seen after sensitization. The mechanical analysis demonstrated hyper-reactivity of the esophagus following acid perfusion, with an increased number and force of the phasic contractions, but the muscle tone did not change. CONCLUSION: Acid perfusion of the esophagus sensitizes the sensory pathways and facilitates secondary contractions. The new model can be used to study abnormal sensory-motor mechanisms in visceral organs. PMID:16038036

Ventilation rates and activity levels of juvenile jumbo squid under metabolic suppression in the oxygen minimum zone.

PubMed

Trübenbach, Katja; Pegado, Maria R; Seibel, Brad A; Rosa, Rui

2013-02-01

The Humboldt (jumbo) squid, Dosidicus gigas, is a part-time resident of the permanent oxygen minimum zone (OMZ) in the Eastern Tropical Pacific and, thereby, it encounters oxygen levels below its critical oxygen partial pressure. To better understand the ventilatory mechanisms that accompany the process of metabolic suppression in these top oceanic predators, we exposed juvenile D. gigas to the oxygen levels found in the OMZ (1% O(2), 1 kPa, 10 °C) and measured metabolic rate, activity cycling patterns, swimming mode, escape jet (burst) frequency, mantle contraction frequency and strength, stroke volume and oxygen extraction efficiency. In normoxia, metabolic rate varied between 14 and 29 μmol O(2) g(-1) wet mass h(-1), depending on the level of activity. The mantle contraction frequency and strength were linearly correlated and increased significantly with activity level. Additionally, an increase in stroke volume and ventilatory volume per minute was observed, followed by a mantle hyperinflation process during high activity periods. Squid metabolic rate dropped more than 75% during exposure to hypoxia. Maximum metabolic rate was not achieved under such conditions and the metabolic scope was significantly decreased. Hypoxia changed the relationship between mantle contraction strength and frequency from linear to polynomial with increasing activity, indicating that, under hypoxic conditions, the jumbo squid primarily increases the strength of mantle contraction and does not regulate its frequency. Under hypoxia, jumbo squid also showed a larger inflation period (reduced contraction frequency) and decreased relaxed mantle diameter (shortened diffusion pathway), which optimize oxygen extraction efficiency (up to 82%/34%, without/with consideration of 60% potential skin respiration). Additionally, they breathe 'deeply', with more powerful contractions and enhanced stroke volume. This deep-breathing behavior allows them to display a stable ventilatory volume per minute, and explains the maintenance of the squid's cycling activity under such O(2) conditions. During hypoxia, the respiratory cycles were shorter in length but increased in frequency. This was accompanied by an increase in the number of escape jets during active periods and a faster switch between swimming modes. In late hypoxia (onset ~170 ± 10 min), all the ventilatory processes were significantly reduced and followed by a lethargic state, a behavior that seems closely associated with the process of metabolic suppression and enables the squid to extend its residence time in the OMZ.

Postmaximal contraction blood volume responses are blunted in obese and type 2 diabetic subjects in a muscle-specific manner

PubMed Central

Sanchez, Otto A.; Copenhaver, Elizabeth A.; Chance, Marti A.; Fowler, Michael J.; Towse, Theodore F.; Kent-Braun, Jane A.

2011-01-01

The purpose of this study was to determine whether there are differences in postisometric contraction blood volume and oxygenation responses among groups of type 2 diabetes mellitus (T2DM), obese, and lean individuals detectable using MRI. Eight T2DM patients were individually matched by age, sex, and race to non-T2DM individuals with similar body mass index (obese) and lean subjects. Functional MRI was performed using a dual-gradient-recalled echo, echo-planar imaging sequence with a repetition time of 1 s and at two echo times (TE = 6 and 46 ms). Data were acquired before, during, and after 10-s isometric dorsiflexion contractions performed at 50 and 100% of maximal voluntary contraction (MVC) force. MRI signal intensity (SI) changes from the tibialis anterior and extensor digitorum longus muscles were plotted as functions of time for each TE. From each time course, the difference between the minimum and the maximum postcontraction SI (ΔSI) were determined for TE = 6 ms (ΔSI6) and TE = 46 ms (ΔSI46), reflecting variations in blood volume and oxyhemoglobin saturation, respectively. Following 50% MVC contractions, the mean postcontraction ΔSI6 values were similar in the three groups. Following MVC only, and in the EDL muscle only, T2DM and obese participants had ∼56% lower ΔSI6 than the lean individuals. Also following MVC only, the ΔSI46 response in the EDL was lower in T2DM subjects than in lean individuals. These data suggest that skeletal muscle small vessel impairment occurs in T2DM and body mass index-matched subjects, in muscle-specific and contraction intensity-dependent manners. PMID:21572006

Inflation from extra dimensions

NASA Astrophysics Data System (ADS)

Levin, Janna J.

1995-02-01

A gravity-driven inflation is shown to arise from a simple higher-dimensional universe. In vacuum, the shear of n > 1 contracting dimensions is able to inflate the remaining three spatial dimensions. Said another way, the expansion of the 3-volume is accelerated by the contraction of the n-volume. Upon dimensional reduction, the theory is equivalent to a four-dimensional cosmology with a dynamical Planck mass. A connection can therefore be made to recent examples of inflation powered by a dilaton kinetic energy. Unfortunately, the graceful exit problem encountered in dilaton cosmologies will haunt this cosmology as well.

17 CFR 190.04 - Operation of the debtor's estate-general.

Code of Federal Regulations, 2010 CFR

2010-04-01

... such unmatched contracts, using the average of the opening price and the settlement price of contracts..., 12a, 19, 23 and 24 (1976 & Supp. V. 1981 and Pub. L. 97-444); secs. 761-766 of the Bankruptcy Reform...

77 FR 29537 - Community Facility Loans

Federal Register 2010, 2011, 2012, 2013, 2014

2012-05-18

... alternate contracting method projects must comply with the requirements for ``maximum open and free... of alternate construction contract methods (such as Design/Build and Construction Management) by the.... Further, these changes will give all applicants greater flexibility in developing projects. Therefore, a...

[Myocardial contractility and hemodynamics in hypothyroidism].

PubMed

Selivonenko, V G

1977-01-01

The author determined the phasic structure of the systole of the left ventricle by the method of polycardiography and hemodynamics in 20 patients suffering from hypothyrodism. Blood plasma and erythrocyte electrolytes were examined at the same time. Patients with hypothyroidism displayed a phasic syndrome of hypodynamia and a marked correlation between the phase of the synchronous contraction, the period of ejection, the strength of contraction of the left ventricle and the electrolyte content. Sodium and magnesium produced the greatest influence on the phasic structure of the systole; potassium and calcium had a lesser effect. The heart stroke volume diminished; as to the cardiac index, expenditure of the energy of cardiac contractions directed to the maintenance of movement of 1 litre of the minute blood volume; the external work, and the peripheral vascular resistance displayed no significant change.

Terror in the Board Room: The Bid-Opening Process

ERIC Educational Resources Information Center

Shoop, James

2009-01-01

Competitive bids and the bid-opening process are the cornerstones of public school purchasing. The bid-opening process does not begin on the day of the bid opening. It begins with good planning by the purchasing agent to ensure that the advertised bid complies with the public school contracts law. In New Jersey, that raises the following…

The effect of laparotomy and external fixator stabilization on pelvic volume in an unstable pelvic injury.

PubMed

Ghanayem, A J; Wilber, J H; Lieberman, J M; Motta, A O

1995-03-01

Determine if laparotomy further destabilizes an unstable pelvic injury and increases pelvic volume, and if reduction and stabilization restores pelvic volume and prevents volume changes secondary to laparotomy. Cadaveric pelvic fracture model. Unilateral open-book pelvic ring injuries were created in five fresh cadaveric specimens by directly disrupting the pubic symphysis, left sacroliac joint, and sacrospinous and sacrotuberous ligaments. Pelvic volume was determined using computerized axial tomography for the intact pelvis, disrupted pelvis with both a laparotomy incision opened and closed, and disrupted pelvis stabilized and reduced using an external fixator with the laparotomy incision opened. The average volume increase in the entire pelvis (from the top of the iliac crests to the bottom of the ischial tuberosities) between a nonstabilized injury with the abdomen closed and then subsequently opened was 15 +/- 5% (423 cc). The average increase in entire pelvic volume between a stabilized and reduced pelvis and nonstabilized pelvis, both with the abdomen open, was 26 +/- 5% (692 cc). The public diastasis increased from 3.9 to 9.3 cm in a nonstabilized pelvis with the abdomen closed and then subsequently opened. Application of a single-pin anterior-frame external fixator reduced the pubic diastasis anatomically and reduced the average entire and true (from the pelvic brim to the ischeal tuberosities) pelvic volumes to within 3 +/- 4 and 8 +/- 6% of the initial volume, respectively. We believe that the abdominal wall provides stability to an unstable pelvic ring injury via a tension band effect on the iliac wings. Our results demonstrate that a laparotomy further destabilized an open-book pelvic injury and subsequently increased pelvic volume and pubic diastasis. This could potentially increase blood loss from the pelvic injury and delay the tamponade effect of reduction and stabilization. A single-pin external fixator prevents the destabilizing effect of the laparotomy and effectively reduces pelvic volume. These data support reduction and temporary stabilization of unstable pelvic injuries before or concomitantly with laparotomy.

An Evaluation of Bioregulators/Modulators as Terrorism and Warfare Agents

DTIC Science & Technology

2003-07-01

such as bronchial and vascular tone and muscle contraction . This opens an unprecedented possibility to use toxic substances that could not be...bronchial smooth muscles and also in the intestines and the uterus bradykinin leads to muscle contraction . Bradykinin is also one the most potent...gout. Bradykinin has a powerful influence in stimulating smooth muscle contraction , inducing hypotension, increasing blood flow and permeability of

Dynamic Contraction of the Positive Column of a Self-Sustained Glow Discharge in Molecular Gas Flow

NASA Astrophysics Data System (ADS)

Shneider, Mikhail

2014-10-01

Contraction of the gas discharge, when current contracts from a significant volume of weakly ionized plasma into a thin arc channel, was attracted attention of scientists for more than a century. Studies of the contraction (also called constriction) mechanisms, besides carrying interesting science, are of practical importance, especially when contraction should be prevented. A set of time-dependent two-dimensional equations for the non-equilibrium weakly-ionized nitrogen/ air plasma is formulated. The process is described by a set of time-dependent continuity equations for the electrons, positive and negative ions; gas and vibrational temperature; by taking into account the convective heat and plasma losses by the transverse flux. Transition from the uniform to contracted state was analyzed. It was shown that such transition experiences a hysteresis, and that the critical current of the transition increases when the pressure (gas density) drops. Possible coexistence of the contracted and uniform state of the plasma in the discharge where the current flows along the density gradient of the background gas was discussed. In this talk the problems related to the dynamic contraction of the current channel inside a quasineutral positive column of a self-sustained glow discharge in molecular gas in a rectangular duct with convection cooling will be discussed. Study presented in this talk was stimulated by the fact that there are large number of experiments on the dynamic contraction of a glow discharge in nitrogen and air flows and a many of possible applications. Similar processes play a role in the powerful gas-discharge lasers. In addition, the problem of dynamic contraction in the large volume of non-equilibrium weakly ionized plasma is closely related to the problem of streamer to leader transitions in lightning and blue jets.

Contract Attorneys Course Deskbook. Volume 2

DTIC Science & Technology

2007-06-21

Fed. Cir. 1994) (upholding the contractor’s submission of a subcontractor’s claim pursuant to a court order). 24-16 d. No claim vs . Defective...Non-DOD contract vehicles (orders placed by DOD and contracts awarded or orders placed by non-DOD entities on behalf of DOD, including franchise ...the federal agencies concerning who took what rights in a patent. Some agencies took title to the patent, while others left ownership with the

Changes in down dead wood volume across a chronosequence of silvicultural openings in southern Indiana forests

Treesearch

Michael A. Jenkins; George R. Parker

1997-01-01

The volume and decay stages of down dead wood were evaluated across a chronosequence of 46 silvicultural openings and 10 uncut control stands to determine how down dead wood volume changes with stand development. Openings ranged in age from 8 to 26 years and were divided into three age groups: (1) 16 years. Individual logs...

Ice Ih anomalies: Thermal contraction, anomalous volume isotope effect, and pressure-induced amorphization.

PubMed

Salim, Michael A; Willow, Soohaeng Yoo; Hirata, So

2016-05-28

Ice Ih displays several anomalous thermodynamic properties such as thermal contraction at low temperatures, an anomalous volume isotope effect (VIE) rendering the volume of D2O ice greater than that of H2O ice, and a pressure-induced transition to the high-density amorphous (HDA) phase. Furthermore, the anomalous VIE increases with temperature, despite its quantum-mechanical origin. Here, embedded-fragment ab initio second-order many-body perturbation (MP2) theory in the quasiharmonic approximation (QHA) is applied to the Gibbs energy of an infinite, proton-disordered crystal of ice Ih at wide ranges of temperatures and pressures. The quantum effect of nuclei moving in anharmonic potentials is taken into account from first principles without any empirical or nonsystematic approximation to either the electronic or vibrational Hamiltonian. MP2 predicts quantitatively correctly the thermal contraction at low temperatures, which is confirmed to originate from the volume-contracting hydrogen-bond bending modes (acoustic phonons). It qualitatively reproduces (but underestimates) the thermal expansion at higher temperatures, caused by the volume-expanding hydrogen-bond stretching (and to a lesser extent librational) modes. The anomalous VIE is found to be the result of subtle cancellations among closely competing isotope effects on volume from all modes. Consequently, even ab initio MP2 with the aug-cc-pVDZ and aug-cc-pVTZ basis sets has difficulty reproducing this anomaly, yielding qualitatively varied predictions of the sign of the VIE depending on such computational details as the choice of the embedding field. However, the temperature growth of the anomalous VIE is reproduced robustly and is ascribed to the librational modes. These solid-state MP2 calculations, as well as MP2 Born-Oppenheimer molecular dynamics, find a volume collapse and a loss of symmetry and long-range order in ice Ih upon pressure loading of 2.35 GPa or higher. Concomitantly, rapid softening of acoustic phonons is observed starting around 2 GPa. They constitute a computational detection of a mechanical instability in ice Ih and the resulting pressure-induced amorphization to HDA.

Ice Ih anomalies: Thermal contraction, anomalous volume isotope effect, and pressure-induced amorphization

NASA Astrophysics Data System (ADS)

Salim, Michael A.; Willow, Soohaeng Yoo; Hirata, So

2016-05-01

Ice Ih displays several anomalous thermodynamic properties such as thermal contraction at low temperatures, an anomalous volume isotope effect (VIE) rendering the volume of D2O ice greater than that of H2O ice, and a pressure-induced transition to the high-density amorphous (HDA) phase. Furthermore, the anomalous VIE increases with temperature, despite its quantum-mechanical origin. Here, embedded-fragment ab initio second-order many-body perturbation (MP2) theory in the quasiharmonic approximation (QHA) is applied to the Gibbs energy of an infinite, proton-disordered crystal of ice Ih at wide ranges of temperatures and pressures. The quantum effect of nuclei moving in anharmonic potentials is taken into account from first principles without any empirical or nonsystematic approximation to either the electronic or vibrational Hamiltonian. MP2 predicts quantitatively correctly the thermal contraction at low temperatures, which is confirmed to originate from the volume-contracting hydrogen-bond bending modes (acoustic phonons). It qualitatively reproduces (but underestimates) the thermal expansion at higher temperatures, caused by the volume-expanding hydrogen-bond stretching (and to a lesser extent librational) modes. The anomalous VIE is found to be the result of subtle cancellations among closely competing isotope effects on volume from all modes. Consequently, even ab initio MP2 with the aug-cc-pVDZ and aug-cc-pVTZ basis sets has difficulty reproducing this anomaly, yielding qualitatively varied predictions of the sign of the VIE depending on such computational details as the choice of the embedding field. However, the temperature growth of the anomalous VIE is reproduced robustly and is ascribed to the librational modes. These solid-state MP2 calculations, as well as MP2 Born-Oppenheimer molecular dynamics, find a volume collapse and a loss of symmetry and long-range order in ice Ih upon pressure loading of 2.35 GPa or higher. Concomitantly, rapid softening of acoustic phonons is observed starting around 2 GPa. They constitute a computational detection of a mechanical instability in ice Ih and the resulting pressure-induced amorphization to HDA.

Ice Ih anomalies: Thermal contraction, anomalous volume isotope effect, and pressure-induced amorphization

DOE Office of Scientific and Technical Information (OSTI.GOV)

Salim, Michael A.; Willow, Soohaeng Yoo; Hirata, So, E-mail: sohirata@illinois.edu

Ice Ih displays several anomalous thermodynamic properties such as thermal contraction at low temperatures, an anomalous volume isotope effect (VIE) rendering the volume of D{sub 2}O ice greater than that of H{sub 2}O ice, and a pressure-induced transition to the high-density amorphous (HDA) phase. Furthermore, the anomalous VIE increases with temperature, despite its quantum-mechanical origin. Here, embedded-fragment ab initio second-order many-body perturbation (MP2) theory in the quasiharmonic approximation (QHA) is applied to the Gibbs energy of an infinite, proton-disordered crystal of ice Ih at wide ranges of temperatures and pressures. The quantum effect of nuclei moving in anharmonic potentials ismore » taken into account from first principles without any empirical or nonsystematic approximation to either the electronic or vibrational Hamiltonian. MP2 predicts quantitatively correctly the thermal contraction at low temperatures, which is confirmed to originate from the volume-contracting hydrogen-bond bending modes (acoustic phonons). It qualitatively reproduces (but underestimates) the thermal expansion at higher temperatures, caused by the volume-expanding hydrogen-bond stretching (and to a lesser extent librational) modes. The anomalous VIE is found to be the result of subtle cancellations among closely competing isotope effects on volume from all modes. Consequently, even ab initio MP2 with the aug-cc-pVDZ and aug-cc-pVTZ basis sets has difficulty reproducing this anomaly, yielding qualitatively varied predictions of the sign of the VIE depending on such computational details as the choice of the embedding field. However, the temperature growth of the anomalous VIE is reproduced robustly and is ascribed to the librational modes. These solid-state MP2 calculations, as well as MP2 Born–Oppenheimer molecular dynamics, find a volume collapse and a loss of symmetry and long-range order in ice Ih upon pressure loading of 2.35 GPa or higher. Concomitantly, rapid softening of acoustic phonons is observed starting around 2 GPa. They constitute a computational detection of a mechanical instability in ice Ih and the resulting pressure-induced amorphization to HDA.« less

48 CFR 2906.301 - Policy.

Code of Federal Regulations, 2010 CFR

2010-10-01

... REQUIREMENTS Other Than Full and Open Competition 2906.301 Policy. (a) Department of Labor acquisitions must... for Administration and Management and, in the case of research and development contracts, also by the... for research and development, the contracting officer has the authority below the simplified...

48 CFR 2906.301 - Policy.

Code of Federal Regulations, 2011 CFR

2011-10-01

... REQUIREMENTS Other Than Full and Open Competition 2906.301 Policy. (a) Department of Labor acquisitions must... for Administration and Management and, in the case of research and development contracts, also by the... for research and development, the contracting officer has the authority below the simplified...

Rail Safety/Equipment Crashworthiness : Volume 4. Executive Summary.

DOT National Transportation Integrated Search

1978-07-01

The document, the fourth of four volumes, summarizes the activities and documentation conducted under this contract. The analysis of the accident data highlighted areas where improvements could be made to improve the occupant protection of passenger ...

Use, misuse and abuse of diuretics.

PubMed

Bartoli, Ettore; Rossi, Luca; Sola, Daniele; Castello, Luigi; Sainaghi, Pier Paolo; Smirne, Carlo

2017-04-01

Resolution of edema requires a correct interpretation of body fluids-related renal function, to excrete the excess volume while restoring systemic hemodynamics and avoiding renal failure. In heart failure, the intensive diuresis should be matched by continuous fluids refeeding from interstitium to plasma, avoiding central volume depletion. The slowly reabsorbed ascites cannot refeed this contracted volume in cirrhosis: the ensuing activation of intrathoracic receptors, attended by increased adrenergic and Renin release, causes more avid sodium retention, producing a positive fluid and Na balance in the face of continuous treatment. High-dose-furosemide creates a defect in tubular Na causing diuresis adequate to excrete the daily water and electrolyte load in Chronic Renal Failure. Diuretic treatment requires care, caution and bedside "tricks" aimed at minimizing volume contraction by correctly assessing the homeostatic system of body fluids and related renal hemodynamics. Copyright © 2017 European Federation of Internal Medicine. Published by Elsevier B.V. All rights reserved.

HERO HELPS for Home Economics Related Occupation Coordinators. Volume I.

ERIC Educational Resources Information Center

Northern Arizona Univ., Flagstaff. Center for Vocational Education.

These 25 modules for independent study comprise the first volume of a two-volume set of HERO (Home Economics Related Occupations) HELPS for student use in competency-based professional development. A management system that includes a filing system, testing, record keeping, and scheduling is discussed. A sample contract and other class management…

Human Rehabilitation Techniques. Contract Papers. Volume III, Part B.

ERIC Educational Resources Information Center

Ross, E. C.; And Others

Volume III, Section B of a six-volume final report (which covers the findings of a research project on policy and technology related to rehabilitation of disabled individuals) presents four papers which examine important rehabilitation-oriented issues. In the first paper, "Transportation Problems of Persons with Disabilities--The Federal Response"…

76 FR 75875 - Defense Federal Acquisition Regulation Supplement; Open Source Software Public Meeting

Federal Register 2010, 2011, 2012, 2013, 2014

2011-12-05

... Regulation Supplement; Open Source Software Public Meeting AGENCY: Defense Acquisition Regulations System... initiate a dialogue with industry regarding the use of open source software in DoD contracts. DATES: Public... be held in the General Services Administration (GSA), Central Office Auditorium, 1800 F Street NW...

Tri-level study of the causes of traffic accidents. Volume 1, Causal factor tabulations and assessments

DOT National Transportation Integrated Search

1977-03-31

This is the Final Report of the "Tri-Level Study of the Causes of Traffic Accidents," performed by the Indiana University Institute for Research in Public Safety (IRPS), under contract to the National Highway Traffic Safety Administration (Contract N...

7 CFR 1145.2 - Program.

Code of Federal Regulations, 2010 CFR

2010-01-01

... Orders; Milk), DEPARTMENT OF AGRICULTURE DAIRY FORWARD PRICING PROGRAM Program Rules § 1145.2 Program. (a) Any handler defined in 7 CFR 1000.9 may enter into forward contracts with producers or cooperative associations of producers for the handler's eligible volume of milk. Milk under forward contract in compliance...

7 CFR 1145.2 - Program.

Code of Federal Regulations, 2011 CFR

2011-01-01

... Orders; Milk), DEPARTMENT OF AGRICULTURE DAIRY FORWARD PRICING PROGRAM Program Rules § 1145.2 Program. (a) Any handler defined in 7 CFR 1000.9 may enter into forward contracts with producers or cooperative associations of producers for the handler's eligible volume of milk. Milk under forward contract in compliance...

75 FR 72845 - New Postal Product

Federal Register 2010, 2011, 2012, 2013, 2014

2010-11-26

... contract for future functional equivalence analyses of the GEPS 3 product. \\1\\ Notice of United States... analysis of the formulas, and certification of the Governors' vote; and Attachment 4--an application for... costing information and volume commitments, do not alter the contracts' functional equivalency. Id. at 3-4...

A novel approach to restore atrial function after the maze procedure in patients with an enlarged left atrium.

PubMed

Marui, Akira; Tambara, Keiichi; Tadamura, Eiji; Saji, Yoshiaki; Sasahashi, Nozomu; Ikeda, Tadashi; Nishina, Takeshi; Komeda, Masashi

2007-08-01

Left atrial (LA) volume reduction surgery concomitant with the maze procedure has been reported to facilitate sinus rhythm recovery even in patients with refractory atrial fibrillation (AF) with an enlarged LA. However, it is unknown whether the procedures can also restore effective atrial function of the enlarged LA with over-stretched myocardium. The maze procedures in association with mitral valve surgery were performed to 57 AF patients with an enlarged LA (LA diameter >or=60mm). Among them, 32 patients had concomitant LA volume reduction surgery (VR group). Another 25 patients did not have the volume reduction (control group). Three months postoperatively LA end-diastolic volume (LAEDV, ml) assessed by magnetic resonance (MR) imaging was larger in the VR group than that in the control group (291+/-117 vs 223+/-81 ml, p<0.05). Postoperatively, sinus rhythm recovery rate was better (84 vs 68%, p<0.05) and LAEDV was drastically smaller (118+/-48 vs 203+/-76 ml, p<0.001) in the VR group than those in the control group. Among the patients with sinus rhythm recovery in both groups, LA contraction ejection fraction (%) improved in the VR group but not in the control group (22.3+/-7.8 vs 10.3+/-4.7%, p<0.001). The LA volume reduction surgery concomitant with the maze procedure restored contraction of the enlarged LA; however, the maze procedure alone did not restore LA contraction in spite of successful sinus rhythm recovery. LA volume reduction surgery may be desirable to the patients with refractory AF with over-stretched LA.

41 CFR 105-72.503 - Competition.

Code of Federal Regulations, 2011 CFR

2011-01-01

... 41 Public Contracts and Property Management 3 2011-01-01 2011-01-01 false Competition. 105-72.503 Section 105-72.503 Public Contracts and Property Management Federal Property Management Regulations System... practical, open and free competition. The recipient shall be alert to organizational conflicts of interest...

75 FR 26916 - Federal Acquisition Regulation: FAR Case 2009-004, Enhancing Contract Transparency

Federal Register 2010, 2011, 2012, 2013, 2014

2010-05-13

... Regulation: FAR Case 2009-004, Enhancing Contract Transparency AGENCY: Department of Defense (DoD), General... commercial or financial information. This transparency effort is intended to promote efficiency in Government... the Administration's memorandum entitled Transparency and Open Government (January 21, 2009...

17 CFR 300.305 - Excluded contracts.

Code of Federal Regulations, 2010 CFR

2010-04-01

... 17 Commodity and Securities Exchanges 3 2010-04-01 2010-04-01 false Excluded contracts. 300.305 Section 300.305 Commodity and Securities Exchanges SECURITIES AND EXCHANGE COMMISSION (CONTINUED) Schedule A to Part 285 RULES OF THE SECURITIES INVESTOR PROTECTION CORPORATION Closeout Or Completion of Open...

76 FR 4751 - Position Limits for Derivatives

Federal Register 2010, 2011, 2012, 2013, 2014

2011-01-26

... designated contract markets (``DCM'') and physical commodity swaps that are economically equivalent to such... non-spot-month limits based on open interest levels as well as establishing Commission-determined spot...''), swaps that are economically equivalent to DCM futures and option contracts with position limits, and...

Investigation of the Potential for Increased use of Civilian Manning in Fleet Support Ships. Volume 2. Narrative

DTIC Science & Technology

1978-02-10

Contract Number N00014-77-C-0016 Enclosure (1) to CNO LTR Ser 96/S590196 DEPARTMENT OF THE NAVY OFFICE OF THE CHIEF OF ...The changes in numbers of military and commercial contract personnel were obtained by subtracting (3) from (1) and (4) from...Commercial Contract maiming F = Full Capability P = Partial Capability L = Lost Capability . -- ’■ -. • NOTE: Subscripts denote the number of

Bridge deck concrete volume change : final contract report.

DOT National Transportation Integrated Search

2010-02-01

Concrete structures such as bridge decks, with large surface area relative to volume, shrink and crack, thus reducing service life performance and increasing operation costs. The project evaluated the early, first 24 hours, and long-term, 180 days, s...

Global Budgets and Technology-Intensive Medical Services.

PubMed

Song, Zirui; Fendrick, A Mark; Safran, Dana Gelb; Landon, Bruce; Chernew, Michael E

2013-06-01

In 2009-2010, Blue Cross Blue Shield of Massachusetts entered into global payment contracts (the Alternative Quality contract, AQC) with 11 provider organizations. We evaluated the impact of the AQC on spending and utilization of several categories of medical technologies, including one considered high value (colonoscopies) and three that include services that may be overused in some situations (cardiovascular, imaging, and orthopedic services). Approximately 420,000 unique enrollees in 2009 and 180,000 in 2010 were linked to primary care physicians whose organizations joined the AQC. Using three years of pre-intervention data and a large control group, we analyzed changes in utilization and spending associated with the AQC with a propensity-weighted difference-in-differences approach adjusting for enrollee demographics, health status, secular trends, and cost-sharing. In the 2009 AQC cohort, total volume of colonoscopies increased 5.2 percent (p=0.04) in the first two years of the contract relative to control. The contract was associated with varied changes in volume for cardiovascular and imaging services, but total spending on cardiovascular services in the first two years decreased by 7.4% (p=0.02) while total spending on imaging services decreased by 6.1% (p<0.001) relative to control. In addition to lower utilization of higher-priced services, these decreases were also attributable to shifting care to lower-priced providers. No effect was found in orthopedics. As one example of a large-scale global payment initiative, the AQC was associated with higher use of colonoscopies. Among several categories of services whose value may be controversial, the contract generally shifted volume to lower-priced facilities or services.

Case Studies in Educational Performance Contracting. Part 1. Conclusions and Implications.

ERIC Educational Resources Information Center

Carpenter, Polly; Hall, George R.

This volume presents conclusions and implications derived from five cities' experience with performance contracting in education: Norfolk, Virginia; Texarkana, Arkansas (with Liberty-Eylau, Texas); Gary, Indiana, Gilroy, California; and Grand Rapids, Michigan. The five case studies cover eight programs in 15 schools. While each study is treated in…

Biceps brachii muscle oxygenation in electrical muscle stimulation.

PubMed

Muthalib, Makii; Jubeau, Marc; Millet, Guillaume Y; Maffiuletti, Nicola A; Ferrari, Marco; Nosaka, Kazunori

2010-09-01

The purpose of this study was to compare between electrical muscle stimulation (EMS) and maximal voluntary (VOL) isometric contractions of the elbow flexors for changes in biceps brachii muscle oxygenation (tissue oxygenation index, TOI) and haemodynamics (total haemoglobin volume, tHb = oxygenated-Hb + deoxygenated-Hb) determined by near-infrared spectroscopy (NIRS). The biceps brachii muscle of 10 healthy men (23-39 years) was electrically stimulated at high frequency (75 Hz) via surface electrodes to evoke 50 intermittent (4-s contraction, 15-s relaxation) isometric contractions at maximum tolerated current level (EMS session). The contralateral arm performed 50 intermittent (4-s contraction, 15-s relaxation) maximal voluntary isometric contractions (VOL session) in a counterbalanced order separated by 2-3 weeks. Results indicated that although the torque produced during EMS was approximately 50% of VOL (P<0.05), there was no significant difference in the changes in TOI amplitude or TOI slope between EMS and VOL over the 50 contractions. However, the TOI amplitude divided by peak torque was approximately 50% lower for EMS than VOL (P<0.05), which indicates EMS was less efficient than VOL. This seems likely because of the difference in the muscles involved in the force production between conditions. Mean decrease in tHb amplitude during the contraction phases was significantly (P<0.05) greater for EMS than VOL from the 10th contraction onwards, suggesting that the muscle blood volume was lower in EMS than VOL. It is concluded that local oxygen demand of the biceps brachii sampled by NIRS is similar between VOL and EMS.

Annealing properties of open volumes in HfSiOx and HfAlOx gate dielectrics studied using monoenergetic positron beams

NASA Astrophysics Data System (ADS)

Uedono, A.; Ikeuchi, K.; Yamabe, K.; Ohdaira, T.; Muramatsu, M.; Suzuki, R.; Hamid, A. S.; Chikyow, T.; Torii, K.; Yamada, K.

2005-07-01

Thin Hf0.6Si0.4Ox and Hf0.3Al0.7Ox films fabricated by metal-organic chemical-vapor deposition and atomic-layer-deposition techniques were characterized using monoenergetic positron beams. Measurements of the Doppler broadening spectra of annihilation radiation and the lifetime spectra of positions indicated that positrons annihilated from the trapped state by open volumes that exist intrinsically in amorphous structures of the films. For HfSiOx, the mean size of the open volumes and their size distribution decreased with increasing postdeposition annealing (PDA) temperature. For HfAlOx, although the overall behavior of the open volumes in response to annealing was similar to that for HfSiOx, PDA caused a separation of the mean size of the open volumes. When this separation occurred, the value of the line-shape parameter S increased, suggesting an oxygen deficiency in the amorphous matrix. This fragmentation of the amorphous matrix can be suppressed by decreasing the annealing time.

SRB Environment Evaluation and Analysis. Volume 3: ASRB Plume Induced Environments

NASA Technical Reports Server (NTRS)

Bender, R. L.; Brown, J. R.; Reardon, J. E.; Everson, J.; Coons, L. W.; Stuckey, C. I.; Fulton, M. S.

1991-01-01

Contract NAS8-37891 was expanded in late 1989 to initiate analysis of Shuttle plume induced environments as a result of the substitution of the Advanced Solid Rocket Booster (ASRB) for the Redesigned Solid Rocket Booster (RSRB). To support this analysis, REMTECH became involved in subscale and full-scale solid rocket motor test programs which further expanded the scope of work. Later contract modifications included additional tasks to produce initial design cycle environments and to specify development flight instrumentation. Volume 3 of the final report describes these analyses and contains a summary of reports resulting from various studies.

Comparison of effects of ingested medium- and long-chain triglyceride on gallbladder volume and release of cholecystokinin and other gut peptides.

PubMed

Isaacs, P E; Ladas, S; Forgacs, I C; Dowling, R H; Ellam, S V; Adrian, T E; Bloom, S R

1987-05-01

In a double-blind, crossover study of the effect of ingested medium-chain triglyceride (MCT) and long-chain triglyceride (LCT) in six normal subjects, the gallbladder did not contract after ingestion of MCT but instead had significantly increased in volume at 2 hr after the meal. Plasma cholecystokinin (CCK) increased after the MCT meal, but gastrin, motilin, pancreatic polypeptide (PP), and GIP were unaffected. The long-chain triglyceride meal evoked a brisk and sustained gallbladder contraction, higher levels of CCK, and a significant increase in plasma PP and GIP levels.

Anterior Cortical Development During Adolescence in Bipolar Disorder

PubMed Central

Najt, Pablo; Wang, Fei; Spencer, Linda; Johnston, Jennifer A.Y.; Cox Lippard, Elizabeth T.; Pittman, Brian P.; Lacadie, Cheryl; Staib, Lawrence H.; Papademetris, Xenophon; Blumberg, Hilary P.

2015-01-01

Background Increasing evidence supports a neurodevelopmental model for bipolar disorder (BD), with adolescence as a critical period in its development. Developmental abnormalities of anterior paralimbic and heteromodal frontal cortices, key structures in emotional regulation processes and central in BD, are implicated. However, few longitudinal studies have been conducted, limiting understanding of trajectory alterations in BD. In this study, we performed longitudinal neuroimaging of adolescents with and without BD and assessed volume changes over time, including changes in tissue overall and within gray and white matter. Larger decreases over time in anterior cortical volumes in the adolescents with BD were hypothesized. Gray matter decreases and white matter increases are typically observed during adolescence in anterior cortices. It was hypothesized that volume decreases over time in BD would reflect alterations in those processes, showing larger gray matter contraction and decreased white matter expansion. Methods Two high-resolution magnetic resonance imaging scans were obtained approximately two-years apart for 35 adolescents with BDI and 37 healthy adolescents. Differences over time between groups were investigated for volume overall and specifically for gray and white matter. Results Relative to healthy adolescents, adolescents with BDI showed greater volume contraction over time in a region including insula, and orbitofrontal, rostral and dorsolateral prefrontal cortices (P<.05, corrected), including greater gray matter contraction and decreased white matter expansion over time, in the BD compared to the healthy group. Conclusions: The findings support neurodevelopmental abnormalities during adolescence in BDI in anterior cortices, include altered developmental trajectories of anterior gray and white matter. PMID:26033826

Conduit purging device and method

NASA Technical Reports Server (NTRS)

Wilks, Michael T. (Inventor)

2011-01-01

A device for purging gas comprises a conduit assembly defining an interior volume. The conduit assembly comprises a first conduit portion having an open first end and an open second end and a second conduit portion having an open first end and a closed second end. The open second end of the first conduit portion is disposed proximate to the open first end of the second conduit portion to define a weld region. The device further comprises a supply element supplying a gas to the interior volume at a substantially constant rate and a vent element venting the gas from the interior volume at a rate that maintains the gas in the interior volume within a pressure range suitable to hold a weld bead in the weld region in equilibrium during formation of a weld to join the first conduit portion and the second conduit portion.

48 CFR 14.201-2 - Part I-The Schedule.

Code of Federal Regulations, 2010 CFR

2010-10-01

... addition to Section B to permit full and open competition (see part 11). (d) Section D, Packaging and... Schedules). (g) Section G, Contract administration data. Include any required accounting and appropriation data and any required contract administration information or instructions other than those on the...

24 CFR 891.535 - Requirements for awarding construction contracts.

Code of Federal Regulations, 2010 CFR

2010-04-01

... bidding (formal advertising) in selecting a construction contractor or the negotiated noncompetitive... be an opportunity for minority owned and women owned businesses to be awarded a contract. (1) Bids... forth for opening of bids. In addition, the invitation shall be publicly advertised. (2) The invitation...

24 CFR 891.535 - Requirements for awarding construction contracts.

Code of Federal Regulations, 2011 CFR

2011-04-01

... bidding (formal advertising) in selecting a construction contractor or the negotiated noncompetitive... be an opportunity for minority owned and women owned businesses to be awarded a contract. (1) Bids... forth for opening of bids. In addition, the invitation shall be publicly advertised. (2) The invitation...

Principles of Social Justice in Educational Research: The Case of Contract Research.

ERIC Educational Resources Information Center

Griffiths, Morwenna

1998-01-01

Delineates small-scale contract-research principles predicated on an understanding of social justice and of research purposes, epistemological issues, and possibilities for ethical and political action. Principles embrace improvement, knowledge and learning, changed belief systems, collaboration and consultation, openness to other communities,…

41 CFR 105-54.301 - Meetings.

Code of Federal Regulations, 2014 CFR

2014-01-01

... 41 Public Contracts and Property Management 3 2014-01-01 2014-01-01 false Meetings. 105-54.301 Section 105-54.301 Public Contracts and Property Management Federal Property Management Regulations System... committee meeting is open to the public unless the Administrator decides otherwise; (b) Each meeting is held...

41 CFR 105-54.301 - Meetings.

Code of Federal Regulations, 2013 CFR

2013-07-01

... 41 Public Contracts and Property Management 3 2013-07-01 2013-07-01 false Meetings. 105-54.301 Section 105-54.301 Public Contracts and Property Management Federal Property Management Regulations System... committee meeting is open to the public unless the Administrator decides otherwise; (b) Each meeting is held...

48 CFR 22.404-8 - Notification of improper wage determination before award.

Code of Federal Regulations, 2010 CFR

2010-10-01

... FEDERAL ACQUISITION REGULATION SOCIOECONOMIC PROGRAMS APPLICATION OF LABOR LAWS TO GOVERNMENT ACQUISITIONS... determination is withdrawn by the Administrative Review Board. (b) In sealed bidding, the contracting officer... determination for the primary site of the work reaches the contracting officer before bid opening, the...

48 CFR 3414.406-3 - Other mistakes disclosed before award.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 48 Federal Acquisition Regulations System 7 2010-10-01 2010-10-01 false Other mistakes disclosed before award. 3414.406-3 Section 3414.406-3 Federal Acquisition Regulations System DEPARTMENT OF EDUCATION ACQUISITION REGULATION CONTRACTING METHODS AND CONTRACT TYPES SEALED BIDDING Opening of Bids and...

75 FR 50986 - Notice of Contract Proposal (NOCP) for Payments to Eligible Advanced Biofuel Producers

Federal Register 2010, 2011, 2012, 2013, 2014

2010-08-18

... remaining available Fiscal Year 2009 program funds. This Notice opens an application window for certain... opening a new application window from August 18, 2010 through September 17, 2010 to accept applications... opening a new application window to accept additional applications for the remaining available Fiscal Year...

First Principles Analysis of Convection in the Earth's Mantle, Eustatic Sea Level and Earth Volume

NASA Astrophysics Data System (ADS)

Kinsland, G. L.

2011-12-01

Steady state convection (convection whereby heat leaving the mantle at the top is equal to the heat entering the mantle across the core mantle boundary and that created within the mantle) of the Earth's mantle is, to a very good approximation, both a constant mass and constant volume process. Mass or volume which moves to one place; e.g., an oceanic ridge; must be accompanied by mass or volume removed from another place. The location of removal, whether from underneath of an ocean or a continent, determines the relationship between oceanic ridge volume and eustatic sea level. If all of the volume entering a ridge were to come from under an oceanic basin then the size of the ridge would not affect eustatic sea level as it would be compensated by a lowering of the sea floor elsewhere. If the volume comes from under a continent then the hypsometry of the continent becomes important. Thus, eustatic sea level is not simply related to convection rate and oceanic ridge volume as posited by Hays and Pitman(1973). Non-steady state convection is still a constant mass process but is not a constant volume process. The mantle experiences a net gain of heat, warms and expands during periods of relatively slow convection (that being convection rate which is less than that necessary to transport incoming and internally created heat to the surface). Conversely, the mantle has a net loss of heat, cools and contracts during periods of relatively rapid convection. The Earth itself expands and contracts as the mantle does. During rapid convection more volume is delivered from the interior of the mantle to the Earth's ridge system than during slow convection. The integral of the difference of ridge system volume between fast and slow convection over a fast-slow convection cycle is a measure of the difference in volume of the mantle over a cycle. The magnitude of the Earth's volume expansion and contraction as calculated from published values for the volume of ocean ridges and is about .05% and has a period of hundreds of millions of years. Hays, J.D., W.C. Pitmann III, 1973, Lithospheric plate motion, sea level changes and climatic and ecological consequences, Nature 246, 18 - 22.

1D-3D coupling for hydraulic system transient simulations

NASA Astrophysics Data System (ADS)

Wang, Chao; Nilsson, Håkan; Yang, Jiandong; Petit, Olivier

2017-01-01

This work describes a coupling between the 1D method of characteristics (MOC) and the 3D finite volume method of computational fluid dynamics (CFD). The coupling method is applied to compressible flow in hydraulic systems. The MOC code is implemented as a set of boundary conditions in the OpenFOAM open source CFD software. The coupling is realized by two linear equations originating from the characteristics equation and the Riemann constant equation, respectively. The coupling method is validated using three simple water hammer cases and several coupling configurations. The accuracy and robustness are investigated with respect to the mesh size ratio across the interface, and 3D flow features close to the interface. The method is finally applied to the transient flow caused by the closing and opening of a knife valve (gate) in a pipe, where the flow is driven by the difference in free surface elevation between two tanks. A small region surrounding the moving gate is resolved by CFD, using a dynamic mesh library, while the rest of the system is modeled by MOC. Minor losses are included in the 1D region, corresponding to the contraction of the flow from the upstream tank into the pipe, a separate stationary flow regulation valve, and a pipe bend. The results are validated with experimental data. A 1D solution is provided for comparison, using the static gate characteristics obtained from steady-state CFD simulations.

Economic impact of switching from an open to a closed enteral nutrition feeding system in an acute care setting.

PubMed

Phillips, Wendy; Roman, Brandis; Glassman, Kendra

2013-08-01

This study compared an open-system (OS) enteral nutrition (EN) delivery system with a closed system (CS). Factors evaluated included nursing time for administration, patient safety factors, and cost of formula and supplies. This study analyzed the cost of formula and supplies in 1 major academic medical center. Data were collected on patients requiring EN in acute care settings. Information collected included formula type and amount of formula ordered and delivered. The average daily cost to feed each adult patient using delivered volume with the OS was $3.84 compared with $4.31 if the patient had been receiving EN from a CS. Considering waste costs, the average cost to feed increased to $4.21 compared with $4.80, respectively. After factoring in increased nursing time with the OS, the cost increased to $9.83. For pediatric patients, formula delivery reached 1 L in only 2% of patient days. The average cost to feed each patient each day using actual delivered volume was $1.89 in the OS and $1.94 in the CS. When factoring in the cost of waste, those costs increased to $2.12 and $3.30, respectively. After factoring in increased nursing time with the OS, the cost increased to $8.92. Due to the higher contract price and increased waste of the CS formulas compared with the OS formulas, a higher daily average cost for formula delivered may be incurred by switching to a CS. However, the CS is more cost-effective when factoring in nursing time.

MUSCLEMOTION: A Versatile Open Software Tool to Quantify Cardiomyocyte and Cardiac Muscle Contraction In Vitro and In Vivo.

PubMed

Sala, Luca; van Meer, Berend J; Tertoolen, Leon G J; Bakkers, Jeroen; Bellin, Milena; Davis, Richard P; Denning, Chris; Dieben, Michel A E; Eschenhagen, Thomas; Giacomelli, Elisa; Grandela, Catarina; Hansen, Arne; Holman, Eduard R; Jongbloed, Monique R M; Kamel, Sarah M; Koopman, Charlotte D; Lachaud, Quentin; Mannhardt, Ingra; Mol, Mervyn P H; Mosqueira, Diogo; Orlova, Valeria V; Passier, Robert; Ribeiro, Marcelo C; Saleem, Umber; Smith, Godfrey L; Burton, Francis L; Mummery, Christine L

2018-02-02

There are several methods to measure cardiomyocyte and muscle contraction, but these require customized hardware, expensive apparatus, and advanced informatics or can only be used in single experimental models. Consequently, data and techniques have been difficult to reproduce across models and laboratories, analysis is time consuming, and only specialist researchers can quantify data. Here, we describe and validate an automated, open-source software tool (MUSCLEMOTION) adaptable for use with standard laboratory and clinical imaging equipment that enables quantitative analysis of normal cardiac contraction, disease phenotypes, and pharmacological responses. MUSCLEMOTION allowed rapid and easy measurement of movement from high-speed movies in (1) 1-dimensional in vitro models, such as isolated adult and human pluripotent stem cell-derived cardiomyocytes; (2) 2-dimensional in vitro models, such as beating cardiomyocyte monolayers or small clusters of human pluripotent stem cell-derived cardiomyocytes; (3) 3-dimensional multicellular in vitro or in vivo contractile tissues, such as cardiac "organoids," engineered heart tissues, and zebrafish and human hearts. MUSCLEMOTION was effective under different recording conditions (bright-field microscopy with simultaneous patch-clamp recording, phase contrast microscopy, and traction force microscopy). Outcomes were virtually identical to the current gold standards for contraction measurement, such as optical flow, post deflection, edge-detection systems, or manual analyses. Finally, we used the algorithm to quantify contraction in in vitro and in vivo arrhythmia models and to measure pharmacological responses. Using a single open-source method for processing video recordings, we obtained reliable pharmacological data and measures of cardiac disease phenotype in experimental cell, animal, and human models. © 2017 The Authors.

Contraction of Abdominal Wall Muscles Influences Incisional Hernia Occurrence and Size

PubMed Central

Lien, Samuel C.; Hu, Yaxi; Wollstein, Adi; Franz, Michael G.; Patel, Shaun P.; Kuzon, William M.; Urbanchek, Melanie G.

2015-01-01

Background Incisional hernias are a complication in 10% of all open abdominal operations and can result in significant morbidity. The purpose of this study is to determine if inhibiting abdominal muscle contraction influences incisional hernia formation during laparotomy healing. We hypothesize that reducing abdominal musculature deformation reduces incisional hernia occurrence and size. Study Design Using an established rat model for incisional hernia, a laparotomy through the linea alba was closed with one mid-incision, fast-absorbing suture. Three groups were compared: a SHAM group (SHAM; n = 6) received no laparotomies while the Saline Hernia (SH; n = 6) and Botox Hernia (BH; n = 6) groups were treated once with equal volume saline or Botulinum Toxin (Botox®, Allergan) before the incomplete laparotomy closure. On post-operative day 14, the abdominal wall was examined for herniation and adhesions and contractile forces were measured for abdominal wall muscles. Results No hernias developed in SHAM rats. Rostral hernias developed in all SH and BH rats. Caudal hernias developed in all SH rats, but in only 50% of the BH rats. Rostral hernias in the BH group were 35% shorter and 43% narrower compared to those in the SH group (p < 0.05). The BH group had weaker abdominal muscles compared to the SHAM and SH groups (p < 0.05). Conclusions In our rat model, partial paralysis of abdominal muscles reduces the number and size of incisional hernias. These results confirm abdominal wall muscle contractions play a significant role in the pathophysiology of incisional hernia formation. PMID:25817097

17 CFR 31.8 - Cover of leverage contracts.

Code of Federal Regulations, 2010 CFR

2010-04-01

... contracts entered into with leverage customers, and must at all times also maintain cover of at least 90... leverage customers. At least 25 percent of the amount of physical commodities subject to open long leverage... entered into with leverage customers: And, provided further, That the leverage transaction merchant...

48 CFR 809.106-1 - Conditions for pre-award surveys.

Code of Federal Regulations, 2012 CFR

2012-10-01

... for contracts covering the products and services of the following: (1) Bakeries. (2) Dairies. (3) Ice cream plants. (4) Laundry and dry cleaning activities. (b) Before any inspection, the contracting... open market purchase of fresh bakery products (such as pies, cakes, and cookies), VA will inspect and...

48 CFR 809.106-1 - Conditions for pre-award surveys.

Code of Federal Regulations, 2011 CFR

2011-10-01

... for contracts covering the products and services of the following: (1) Bakeries. (2) Dairies. (3) Ice cream plants. (4) Laundry and dry cleaning activities. (b) Before any inspection, the contracting... open market purchase of fresh bakery products (such as pies, cakes, and cookies), VA will inspect and...

48 CFR 809.106-1 - Conditions for pre-award surveys.

Code of Federal Regulations, 2013 CFR

2013-10-01

... for contracts covering the products and services of the following: (1) Bakeries. (2) Dairies. (3) Ice cream plants. (4) Laundry and dry cleaning activities. (b) Before any inspection, the contracting... open market purchase of fresh bakery products (such as pies, cakes, and cookies), VA will inspect and...

48 CFR 809.106-1 - Conditions for pre-award surveys.

Code of Federal Regulations, 2014 CFR

2014-10-01

... for contracts covering the products and services of the following: (1) Bakeries. (2) Dairies. (3) Ice cream plants. (4) Laundry and dry cleaning activities. (b) Before any inspection, the contracting... open market purchase of fresh bakery products (such as pies, cakes, and cookies), VA will inspect and...

17 CFR 1.3 - Definitions.

Code of Federal Regulations, 2011 CFR

2011-04-01

... juice, and all other goods and articles, except onions as provided in Pub. L. 85-839, and all services... contracts plus or minus any unrealized gain or loss on such contracts; and (2) In the case of foreign... representing premiums paid or received, plus any other funds required to guarantee or secure open transactions...

Higher surgeon annual volume, but not years of experience, is associated with reduced rates of postoperative complications and reoperations after open abdominal aortic aneurysm repair.

PubMed

Dubois, Luc; Allen, Britney; Bray-Jenkyn, Krista; Power, Adam H; DeRose, Guy; Forbes, Thomas L; Duncan, Audra; Shariff, Salimah Z

2018-06-01

Volume-outcome relationships for open abdominal aortic aneurysm (AAA) repair have received less attention in publicly funded health systems. Furthermore, the roles of surgeon seniority (years of experience) and composite volume (encompassing all major arterial cases) on outcomes after open AAA repair are less well known. We sought to determine the effects of surgeon volume, surgeon years of experience, and composite volume on outcomes after elective open AAA repairs performed in Ontario, Canada. Using a population-based, prospectively collected health administrative database, all elective open AAA repairs occurring in the province of Ontario from 2005 to 2014 were identified. Surgeon annual volume was classified by quintiles, with the highest volume quintile acting as the reference category. Multivariable logistic regression modeling was used, adjusting for patient factors (age, sex, comorbidities, year of procedure, income) to investigate the relationship between surgeon annual volume and 30-day mortality, 30-day major complications, 30-day reoperations, 1-year mortality, and 1-year reoperations (related to index procedure). The potential effects of annual surgeon composite volume and surgeon years of experience on postoperative outcomes were also explored. A total of 7211 elective open AAA repairs performed by 101 surgeons were identified between 2005 and 2014. Most of the operations were performed by vascular surgeons (81.5%), followed by cardiac (12.1%) and general surgeons (6.1%). Median number of procedures in the lowest quintile group was 3 repairs/y, whereas the highest quintile group performed 54 repairs/y. Overall 30-day mortality was 3%. No difference in mortality was detected in comparing the lowest with the highest volume groups (1.89% vs 3.01%; adjusted odds ratio [OR], 0.60; 95% confidence interval [CI], 0.27-1.33). The lowest volume group exhibited a higher 30-day complication rate (28.0% vs 20.4%; OR, 1.54; 95% CI, 1.15-2.06) and 30-day reoperation rate (10.53% vs 6.73%; OR, 1.64; 95% CI, 1.13-2.38) compared with the highest volume group. No effect of surgeon volume on 1-year mortality or 1-year reoperation was observed. Similarly, composite volume and surgeon years of experience were not associated with postoperative outcomes. In a single-payer system with a relatively high number of open AAA repairs/surgeon per year, surgeon annual volume had no effect on postoperative mortality but was associated with lower postoperative complication and reoperation rates. Copyright © 2017 Society for Vascular Surgery. Published by Elsevier Inc. All rights reserved.

Contraction frequency after administration of misoprostol in obese versus nonobese women.

PubMed

Stefely, Erin; Warshak, Carri R

2018-04-30

To examine impact of obesity on contraction frequency following misoprostol. Our hypothesis is that an increased volume of distribution reduces the bioavailability of misoprostol and may be an explanation for reduced efficacy. We examined the contraction frequency as a surrogate marker for bioavailability of misoprostol. We compared the rate of contractions at five time intervals in 313 subjects: prior to administration, and at four intervals post administration. We compared number of contractions in obese versus nonobese. As a planned secondary analysis, we then compared the rate of change in contractions per hour at four time intervals: a repeated measures analysis to compare the rate of change in contractions per hour over the 5-hour window controlling for race (White versus non-White) and parity (primiparous versus multiparous). General linear model and repeated measures analysis were conducted to report the parameter estimates, least square means, difference of least square means, and p values. Nonobese women presented with more contractions at baseline, 7 ± 5 versus 4 ± 5 c/h, p < .001. At all four time intervals after misoprostol administration obese women had fewer contractions per hour. The rate of change in contraction frequency after administration found obese women had a lower rate of increase in contraction frequency over the course of all four hours. We found a least squares means estimate (c/h): first hour (-0.87), p = .08, second hour (-2.43), p = .01, third hour (-1.80), p = .96, and fourth hour (-2.98), p = .007. Obese women have a lower rate of contractions per hour at baseline and at four intervals after misoprostol administration. In addition, the rate of change in the increase in contractions/hour also was reduced in obese women versus nonobese women. This suggests a lower bioavailability of misoprostol in women with a larger volume of distribution which would likely impact the efficacy of misoprostol in obese women when given the same dose of misoprostol. It is unknown if higher misoprostol dosing would increase efficacy of misoprostol in obese women.

Increased fall risk is associated with elevated co-contraction about the ankle during static balance challenges in older adults.

PubMed

Nelson-Wong, Erika; Appell, Ryan; McKay, Mike; Nawaz, Hannah; Roth, Joanna; Sigler, Robert; Third, Jacqueline; Walker, Mark

2012-04-01

Falls are a leading contributor to disability in older adults. Increased muscle co-contraction in the lower extremities during static and dynamic balance challenges has been associated with aging, and also with a history of falling. Co-contraction during static balance challenges has not been previously linked with performance on clinical tests designed to ascertain fall risk. The purpose of this study was to investigate the relationship between co-contraction about the ankle during static balance challenges with fall risk on a commonly used dynamic balance assessment, the Four Square Step Test (FSST). Twenty-three volunteers (mean age 73 years) performed a series of five static balance challenges (Romberg eyes open/closed, Sharpened Romberg eyes open/closed, and Single Leg Standing) with continuous electromyography (EMG) of bilateral tibialis anterior and gastrocnemius muscles. Participants then completed the FSST and were categorized as 'at-risk' or 'not-at-risk' to fall based on a cutoff time of 12 s. Co-contraction was quantified with co-contraction index (CCI). CCI during narrow base conditions was positively correlated with time to complete FSST. High CCIs during all static balance challenges with the exception of Romberg stance with eyes closed were predictive of being at-risk to fall based on FSST time, odds ratio 19.3. The authors conclude that co-contraction about the ankle during static balance challenges can be predictive of performance on a dynamic balance test.

Contractor for geopressured-geothermal sites: Final contract report, Volume 1, fiscal years 1986--1990 (5 years), testing of wells through October 1990. Appendix A, Volume 2, Gladys McCall Site (Cameron Parish LA); Appendix B-1, Volume 3, Pleasant Bayou Site; Appendix B-2, Volume 4, Pleasant Bayou Site; Appendix C, Volume 5, Willis Hulin Site

DOE Office of Scientific and Technical Information (OSTI.GOV)

Not Available

1992-09-01

Field tests and studies were conducted to determine the production behavior of geopressured-geothermal reservoirs and their potential as future energy sources. Results are presented for Gladys McCall Site, Pleasant Bayou Site, and Hulin Site.

EVALUATION OF GROUNDWATER EXTRACTION REMEDIES - VOLUME II

EPA Science Inventory

This volume was prepared as part of an evaluation of groundwater extraction remedies completed under EPA Contract No. 68-W8-0098. It presents 19 case studies of individual sites where ground-water extraction systems have been implemented. These case studies present site characte...

Defense Small Business Innovation Research Program (SBIR). Volume 4. Defense Agencies Abstracts of Phase 1 Awards. 1990

DTIC Science & Technology

1990-01-01

RI 02871 Program Manager: T. DEEGAN Contract #: Title: LF DETECTION OF AIRCRAFT Topic #: DARPA90-049 Office: ID #: 50506 TECHNICAL ABSTRACT - COMBAT...INNOVATION RESEARCH PROGRAM - PHASE I SDIO Solicitation 90.1 TORRANCE, CA 90505 Program Manager: JAMES E CRAIG Contract #: Title: NONINTRUSIVE OPTICAL

17 CFR 41.12 - Indexes underlying futures contracts trading for fewer than 30 days.

Code of Federal Regulations, 2010 CFR

2010-04-01

... 17 Commodity and Securities Exchanges 1 2010-04-01 2010-04-01 false Indexes underlying futures contracts trading for fewer than 30 days. 41.12 Section 41.12 Commodity and Securities Exchanges COMMODITY... reported transactions used in calculating dollar value of trading volume is reported in a currency other...

Optical induction of muscle contraction at the tissue scale through intrinsic cellular amplifiers.

PubMed

Yoon, Jonghee; Choi, Myunghwan; Ku, Taeyun; Choi, Won Jong; Choi, Chulhee

2014-08-01

The smooth muscle cell is the principal component responsible for involuntary control of visceral organs, including vascular tonicity, secretion, and sphincter regulation. It is known that the neurotransmitters released from nerve endings increase the intracellular Ca(2+) level in smooth muscle cells followed by muscle contraction. We herein report that femtosecond laser pulses focused on the diffraction-limited volume can induce intracellular Ca(2+) increases in the irradiated smooth muscle cell without neurotransmitters, and locally increased intracellular Ca(2+) levels are amplified by calcium-induced calcium-releasing mechanisms through the ryanodine receptor, a Ca(2+) channel of the endoplasmic reticulum. The laser-induced Ca(2+) increases propagate to adjacent cells through gap junctions. Thus, ultrashort-pulsed lasers can induce smooth muscle contraction by controlling Ca(2+), even with optical stimulation of the diffraction-limited volume. This optical method, which leads to reversible and reproducible muscle contraction, can be used in research into muscle dynamics, neuromuscular disease treatment, and nanorobot control. Copyright © 2014 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

76 FR 34634 - Federal Acquisition Regulation; Prioritizing Sources of Supplies and Services for Use by the...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-06-14

... contracts before commercial sources in the open market. The proposed rule amends FAR 8.002 as follows: The... requirements for supplies and services from commercial sources in the open market. The proposed FAR 8.004 would... subpart 8.6). (b) Commercial sources (including educational and non-profit institutions) in the open...

Defense Small Business Innovation Research Program (SBIR). Volume 3. Air Force Abstracts of Phase 1 Awards from FY 1988 SBIR Solicitation

DTIC Science & Technology

1989-05-01

THE TARGET DOPPLER FREQUENCIES. ADAPTIVE SENSORS INC 216 PICO BLVD - STE 8 SANTA MONICA, CA 90405 CONTRACT NUMBER: JOHN S BAILEY TITLE: SPATIALLY...APPLIED RESEARCH ASSOCS INC 4300 SAN MATEO BLVD NE - STE A220 ALBUQUERQUE, NM 87110 CONTRACT NUMBER: FRANK A MAESTAS TITLE: PARAMETRIC ANALYSIS OF EXPLOSIVE...VERIFIED THROUGH SUBSCALE FABRICATION AND TEST. AV DYNAMICS INC 825 MYRTLE AVE MONROVIA, CA 91016 CONTRACT NUMBER: DR P B S LISSAMAN TITLE: LIGHT WEIGHT

Defense Small Business Innovation Research Program (SBIR). Volume 1. Army Projects, Abstracts of Phase 1 Awards from FY 1989 SBIR Solicitation

DTIC Science & Technology

1990-04-01

CONTRACT NUMBER: WILLIAM R BELCHER TITLE: SORBENTS FOR DECONTAMINATION OF CHEMICAL WARFARE AGENTS TOIC# 2 OFFICE: CRDEC IDENT#: 33401 SMALL BUSINESS...INDUSTRIES PO BOX 4338 - 4 LEONARD ST METUCHEN, NJ 08340 CONTRACT NUMBER: DR ASIT ROY TITLE: NOVEL ACTIVE SORBENTS FOR DECONTAMINATION OF CHEMICAL WARFARE AGE...DEFERRED TO PHASE II. BELTRAN INC 1133 E 35TH ST BROOKLYN, NY 11210 CONTRACT NUMBER: DR CONSTANCE SIMO TITLE: CONTROLLED CHEMICAL MODIFICATION OF

Acquisition forecast: Fiscal year 1995

NASA Technical Reports Server (NTRS)

1995-01-01

This volume includes projections of all anticipated FY95, and beyond, NASA contract actions above $25,000 that small and small disadvantaged businesses may be able to perform under direct contract with the government or as subcontractors. The forecast consolidates anticipated procurements at each NASA center into an agencywide report, with the aim of increasing industries' advance knowledge of NASA requirements and enhancing competition in contracting. Each center forecast report is divided into three principal categories of procurement: research and development, services, and supplies and equipment.

Human Electro-Muscular Incapacitation (HEMI) Devices Characterization: A Comparative Study on Stress and the Physiological Effects on Swine

DTIC Science & Technology

2011-07-07

depending upon the device. As noted earlier, while the Stinger™S-200 and TASER ® X26 both resulted in tetany (sustained muscle contraction ), the cyclic...artificially maintained by the muscle contraction of the HEMI application. The stoppage of the HEMI “unmasked” the hypovolemia and the blood pressure...dropped. (2) The animals had normal blood volume with peripheral vascular resistance maintained by the HEMI ( muscle contraction ). When the HEMI

The CCTC Quick-Reacting General War Gaming System (QUICK) Program Maintenance Manual. Volume I. Data Management Subsystem. Change 3.

DTIC Science & Technology

1980-05-22

cross -referenced with the number of the data transaction listed in the data module quality con- trol list NVB Integer variable used to...Organization of the Joint Chiefs of Staff. Technical support was provided by System Sciences, Incorporated under Contract Number DCA100-75-C-0019. Change set... Contract Number DCA 100-75-C-0019. Change set two was prepared u nder Contract Number DCA 100-78-C-0035. Computer Sciences Corporation prepared change

The Impact of Price Transparency for Surgical Services.

PubMed

Mehta, Ambar; Xu, Tim; Bai, Ge; Hawley, Kristy L; Makary, Martin A

2018-04-01

Increasing insurance deductibles have prompted some medical centers to initiate transparent pricing. However, the impact of price transparency (PT) on surgical volume, revenue, and patient satisfaction is unknown, along with the barriers to achieving PT. We identified ambulatory surgical centers in the Free Market Medical Association database that publicly list prices for surgical services online. Six of eight centers (75%) responded to our data collection inquiry. Among five centers that reported their patient volume and revenue after adopting PT, patient volume increased by a median of 50 per cent (range 10-200%) at one year. Four centers (80%) reported an increase in revenue by a median of 30 per cent (range 4-75%), whereas three centers (60%) experienced an increase in third-party administrator contracts with the average increase being seven new third-party administrator contracts (range = 2-12 contracts). Three centers (50%) reported a reduction in their administrative burden and five centers (83%) reported an increase in patient satisfaction and patient engagement after PT. The leading barrier reported to making prices transparent was discouragement from another practice, hospital, or insurance company. The findings of this preliminary study may help guide medical practices in designing and implementing PT strategies.

Spinal mechanism of micturition reflex inhibition by naftopidil in rats.

PubMed

Sugaya, Kimio; Nishijima, Saori; Kadekawa, Katsumi; Ashitomi, Katsuhiro; Ueda, Tomoyuki; Yamamoto, Hideyuki

2014-10-29

We investigated the spinal mechanism through which naftopidil inhibits the micturition reflex by comparing the effects of noradrenaline and naftopidil in rats. The following were investigated: the influence of oral naftopidil on plasma monoamine and amino acid levels, the distribution of oral 14C-naftopidil, the effects of intravenous (IV) or intrathecal (IT) injection of noradrenaline or naftopidil on isovolumetric bladder contractions, amino acid levels in the lumbosacral spinal cord after IT noradrenaline or naftopidil, and the effects of IT naftopidil and strychnine and/or bicuculline on isovolumetric bladder contractions. Oral naftopidil decreased the plasma adrenaline level, while it increased the serotonin and glycine levels. After oral administration, 14C-naftopidil was detected in the spinal cord and cerebrum, as well as in plasma and the prostate gland. When the bladder volume was below the threshold for isovolumetric reflex contractions, IV (0.1mg) or IT (0.1μg) noradrenaline evoked bladder contractions, but IV (1mg) or IT (0.01-1μg) naftopidil did not. When the bladder volume was above the threshold for isovolumetric reflex contractions, IV or IT noradrenaline transiently abolished bladder contractions. IT noradrenaline decreased the levels of glycine and gamma-aminobutyric acid (GABA) in the lumbosacral cord, while IT naftopidil increased the GABA level. IT strychnine and/or bicuculline blocked the inhibitory effect of IT naftopidil on bladder contractions. Naftopidil inhibits the micturition reflex by blocking α1 receptors, as well as by the activation of serotonergic, glycinergic, and GABAergic neurons in the central nervous system. Copyright © 2014 Elsevier Inc. All rights reserved.

Purinergic and cholinergic components of bladder contractility and flow.

PubMed

Theobald, R J

1995-01-01

The role of ATP as a neurotransmitter/neuromodulator in the urinary tract has been the subject of much study, particularly whether ATP has a functional role in producing urine flow. Recent studies suggested significant species variation, specifically a variation between cat and other species. This study was performed to determine the in vivo response of cat urinary bladder to pelvic nerve stimulation (PNS) and to the exogenous administration of cholinergic and purinergic agents. In anesthetized cats, bladder contractions and fluid expulsion was measured in response to PNS and to the exogenous administration of cholinergic and purinergic agents. Fluid was instilled into the bladder and any fluid expelled by bladder contractions induced by PNS or exogenous agents was collected in a beaker. The volume was measured in a graduated cylinder and recorded. PNS, carbachol and APPCP produced sustained contractions with significant expulsion of fluid. ATP, ACh and hypogastric nerve stimulation did not produce any significant expulsion of fluid. Atropine, a cholinergic antagonist, inhibited PNS contractions and fluid expulsion with no effect on purinergic actions. There was a significant relationship between the magnitude of the contraction, duration of the contractions and volume of fluid expelled. The data and information from other studies, strongly suggests a functional role for ATP as a cotransmitter in the lower urinary tract different from ACh's role. ATP stimulation of a specific purinergic receptor plays a role in initiation of bladder contractions and perhaps in the initiation of urine flow from the bladder. ACh's role is functionally different and appears to be more involved in maintenance of contractile activity and flow.

Sensory feedback from the urethra evokes state-dependent lower urinary tract reflexes in rat.

PubMed

Danziger, Zachary C; Grill, Warren M

2017-08-15

The lower urinary tract is regulated by reflexes responsible for maintaining continence and producing efficient voiding. It is unclear how sensory information from the bladder and urethra engages differential, state-dependent reflexes to either maintain continence or promote voiding. Using a new in vivo experimental approach, we quantified how sensory information from the bladder and urethra are integrated to switch reflex responses to urethral sensory feedback from maintaining continence to producing voiding. The results demonstrate how sensory information regulates state-dependent reflexes in the lower urinary tract and contribute to our understanding of the pathophysiology of urinary retention and incontinence where sensory feedback may engage these reflexes inappropriately. Lower urinary tract reflexes are mediated by peripheral afferents from the bladder (primarily in the pelvic nerve) and the urethra (in the pudendal and pelvic nerves) to maintain continence or initiate micturition. If fluid enters the urethra at low bladder volumes, reflexes relax the bladder and evoke external urethral sphincter (EUS) contraction (guarding reflex) to maintain continence. Conversely, urethral flow at high bladder volumes, excites the bladder (micturition reflex) and relaxes the EUS (augmenting reflex). We conducted measurements in a urethane-anaesthetized in vivo rat preparation to characterize systematically the reflexes evoked by fluid flow through the urethra. We used a novel preparation to manipulate sensory feedback from the bladder and urethra independently by controlling bladder volume and urethral flow. We found a distinct bladder volume threshold (74% of bladder capacity) above which flow-evoked bladder contractions were 252% larger and evoked phasic EUS activation 2.6 times as often as responses below threshold, clearly demonstrating a discrete transition between continence (guarding) and micturition (augmenting) reflexes. Below this threshold urethral flow evoked tonic EUS activity, indicative of the guarding reflex, that was proportional to the urethral flow rate. These results demonstrate the complementary roles of sensory feedback from the bladder and urethra in regulating reflexes in the lower urinary tract that depend on the state of the bladder. Understanding the neural control of functional reflexes and how they are mediated by sensory information in the bladder and urethra will open new opportunities, especially in neuromodulation, to treat pathologies of the lower urinary tract. © 2017 The Authors. The Journal of Physiology © 2017 The Physiological Society.

41 CFR 50-203.8 - Hearing.

Code of Federal Regulations, 2011 CFR

2011-07-01

... 41 Public Contracts and Property Management 1 2011-07-01 2009-07-01 true Hearing. 50-203.8 Section...-Healey Public Contracts Act § 50-203.8 Hearing. (a) The hearing for the purpose of taking evidence upon a... law judge may be designated to take his place. Such hearings shall be open to the public unless...

41 CFR 50-203.8 - Hearing.

Code of Federal Regulations, 2012 CFR

2012-07-01

... 41 Public Contracts and Property Management 1 2012-07-01 2009-07-01 true Hearing. 50-203.8 Section...-Healey Public Contracts Act § 50-203.8 Hearing. (a) The hearing for the purpose of taking evidence upon a... law judge may be designated to take his place. Such hearings shall be open to the public unless...

41 CFR 50-203.8 - Hearing.

Code of Federal Regulations, 2014 CFR

2014-07-01

... 41 Public Contracts and Property Management 1 2014-07-01 2014-07-01 false Hearing. 50-203.8...-Healey Public Contracts Act § 50-203.8 Hearing. (a) The hearing for the purpose of taking evidence upon a... law judge may be designated to take his place. Such hearings shall be open to the public unless...

17 CFR Appendix A to Part 190 - Bankruptcy Forms

Code of Federal Regulations, 2011 CFR

2011-04-01

...)(3) (“all other property”). 10. Be aware of any contracts in delivery position and rules pertaining... an open commodity contract and is: —registered in your name, —not transferable by delivery, and —not... neither in bearer form nor otherwise transferable by delivery. 4. Any warehouse receipt bill of lading or...

48 CFR 22.1012-2 - Wage determinations based on collective bargaining agreements.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 48 Federal Acquisition Regulations System 1 2010-10-01 2010-10-01 false Wage determinations based... new or changed collective bargaining agreement less than 10 days before bid opening and the... contracting agency after award of a successor contract or a modification as specified in 22.1007(b), provided...

13 CFR 121.1004 - What time limits apply to size protests?

Code of Federal Regulations, 2013 CFR

2013-01-01

..., after bid or proposal opening. (2) Negotiated procurement. A protest must be received by the contracting... paragraph (e), for purposes of the SBIR program the contracting officer and SBA may file a protest in... purposes of the SBIR and STTR programs. Notwithstanding paragraph (e), for purposes of the SBIR and STTR...

22 CFR 228.54 - Suppliers of services-foreign government-owned organizations.

Code of Federal Regulations, 2011 CFR

2011-04-01

... organizations. 228.54 Section 228.54 Foreign Relations AGENCY FOR INTERNATIONAL DEVELOPMENT RULES ON SOURCE... contract will be open to firms from countries or areas included in the authorized geographic code and... interested in competing for the contract. (c) Services are not available from any other source. (d) Foreign...

Administrative Preparedness Strategies: Expediting Procurement and Contracting Cycle Times During an Emergency.

PubMed

Hurst, David; Sharpe, Sharon; Yeager, Valerie A

We assessed whether administrative preparedness processes that were intended to expedite the acquisition of goods and services during a public health emergency affect estimated procurement and contracting cycle times. We obtained data from 2014-2015 applications to the Hospital Preparedness Program and Public Health Emergency Preparedness (HPP-PHEP) cooperative agreements. We compared the estimated procurement and contracting cycle times of 61 HPP-PHEP awardees that did and did not have certain administrative processes in place. Certain processes, such as statutes allowing for procuring and contracting on the open market, had an effect on reducing the estimated cycle times for obtaining goods and services. Other processes, such as cooperative purchasing agreements, also had an effect on estimated procurement time. For example, awardees with statutes that permitted them to obtain goods and services in the open market had an average procurement cycle time of 6 days; those without such statutes had a cycle time of 17 days ( P = .04). PHEP awardees should consider adopting these or similar processes in an effort to reduce cycle times.

Anterior Cortical Development During Adolescence in Bipolar Disorder.

PubMed

Najt, Pablo; Wang, Fei; Spencer, Linda; Johnston, Jennifer A Y; Cox Lippard, Elizabeth T; Pittman, Brian P; Lacadie, Cheryl; Staib, Lawrence H; Papademetris, Xenophon; Blumberg, Hilary P

2016-02-15

Increasing evidence supports a neurodevelopmental model for bipolar disorder (BD), with adolescence as a critical period in its development. Developmental abnormalities of anterior paralimbic and heteromodal frontal cortices, key structures in emotional regulation processes and central in BD, are implicated. However, few longitudinal studies have been conducted, limiting understanding of trajectory alterations in BD. In this study, we performed longitudinal neuroimaging of adolescents with and without BD and assessed volume changes over time, including changes in tissue overall and within gray and white matter. Larger decreases over time in anterior cortical volumes in the adolescents with BD were hypothesized. Gray matter decreases and white matter increases are typically observed during adolescence in anterior cortices. It was hypothesized that volume decreases over time in BD would reflect alterations in those processes, showing larger gray matter contraction and decreased white matter expansion. Two high-resolution magnetic resonance imaging scans were obtained approximately 2 years apart for 35 adolescents with bipolar I disorder (BDI) and 37 healthy adolescents. Differences over time between groups were investigated for volume overall and specifically for gray and white matter. Relative to healthy adolescents, adolescents with BDI showed greater volume contraction over time in a region including insula and orbitofrontal, rostral, and dorsolateral prefrontal cortices (p < .05, corrected), including greater gray matter contraction and decreased white matter expansion over time, in the BD compared with the healthy group. The findings support neurodevelopmental abnormalities during adolescence in BDI in anterior cortices, including altered developmental trajectories of anterior gray and white matter. Published by Elsevier Inc.

Transient deformation following the 30 January 1997 dike intrusion at Kīlauea volcano, Hawai'i

NASA Astrophysics Data System (ADS)

Desmarais, Emily K.; Segall, Paul

2007-02-01

On 30 January 1997 an intrusion on Kīlauea volcano opened a new fissure within the East Rift Zone (ERZ) at Nāpau Crater, 3 km uprift from the ongoing eruptions at Pu’u ’Ō’ō. The fissure eruption lasted 22 h and opened a 5.1 km long, nearly vertical dike 1.9 m, extending from the surface to a depth of 2.4 km (Owen et al. 2000b). During the eruption, the lava pond at Pu’u ’Ō’ō drained, and eruptions ceased there. Pu’u ’Ō’ō eventually refilled in late February and eruptions resumed there on 28 March 1997. Continuous GPS data show a large transient following the 30 January 1997 dike intrusion. After lengthening 40 cm during the initial eruption, the baseline between two stations spanning the ERZ lengthened an additional 10 cm over the following 6 months. A coastal station KAEP also exhibited transient deformation, as it continued to move southward (5 cm) over the same 6-month period. The baseline between two stations spanning Kīlauea’s summit caldera contracted sharply during the eruption, but gradually recovered to slightly longer than its previous length 2 months after the intrusion. We use the extended network inversion filter (McGuire and Segall 2003) to invert continuous GPS data for volume change of a spherical pressure source under Kīlauea’s summit, opening distribution on a nearly vertical dike in the ERZ and potential slip on a decollement 9 km beneath the south flank. Following the 30 January intrusion, rift extension continued below the initial dike intrusion for the duration of the transient. Decollement slip, regardless of its assumed depth, is not required to fit the data. The modeled transient summit reinflation and rift opening patterns under Nāpau crater coincide with changes in observed behavior of Pu’u ’Ō’ō’s lava pond. Rift opening accelerated while Pu’u ’Ō’ō eruptions paused and began to decelerate after the lava pond reappeared nearly a month after the Nāpau eruption. The transient deformation is interpreted as resulting from shallow accommodation of the new dike volume.

A transaction costs analysis of changing contractual relations in the English NHS.

PubMed

Marini, Giorgia; Street, Andrew

2007-09-01

The English National Health Service has replaced locally negotiated block contracting arrangements with a system of national prices to pay for hospital activity. This paper applies a transaction costs approach to quantify and analyse the nature of how contracting costs have changed as a consequence. Data collection was based on semi-structured interviews with key stakeholders from hospitals and Primary Care Trusts, which purchase hospital services. Replacing block contracting with activity based funding has led to lower costs of price negotiation, but these are outweighed by higher costs associated with volume control, of data collection, contract monitoring, and contract enforcement. There was consensus that the new contractual arrangements were preferable, but the benefits will have to be demonstrated formally in future.

36 CFR 223.36 - Volume determination.

Code of Federal Regulations, 2010 CFR

2010-07-01

..., measuring, weighing, or counting the logs or other products, or by measuring the trees before cutting. If the contract or permit provides for the determination of volume by tree measurement and the timber has been paid for, the marking or otherwise designating of the tree authorizes cutting and removal...

36 CFR 223.50 - Periodic payments.

Code of Federal Regulations, 2010 CFR

2010-07-01

...) Total contract value is the product of the estimated volume of the sale multiplied by the rates bid by..., estimated remaining unscaled volume or, in a tree measurement sale, the estimated remaining quantities by... Section 223.50 Parks, Forests, and Public Property FOREST SERVICE, DEPARTMENT OF AGRICULTURE SALE AND...

Performance of new alternative providers of primary care services in England: an observational study

PubMed Central

Greaves, Felix; Laverty, Anthony A; Pape, Utz; Ratneswaren, Anenta; Majeed, Azeem

2015-01-01

Summary Objectives Health system reforms in England are opening broad areas of clinical practice to new providers of care. As part of these reforms, new entrants – including private companies – have been allowed into the primary care market under ‘alternative provider of medical services’ contracting mechanisms since 2004. The characteristics and performance of general practices working under new alternative provider contracts are not well described. We sought to compare the quality of care provided by new entrant providers to that provided by the traditional model of general practice. Design Open cohort study of English general practices. We used linear regression in cross-sectional and time series analyses, adjusting for practice and population characteristics, to compare quality in practices using alternative provider contracts to traditional practices. We created regression models using practice fixed effects to estimate the impact of practices changing to the new contract type. Setting The English National Health Service. Participants All general practices open from 2008/2009 to 2012/2013. Main outcome measures Seventeen established quality indicators – covering clinical effectiveness, efficiency, access and patient experience. Results In total, 4.1% (347 of 8300) of general practices in England were run by alternative contract providers. These practices tended to be smaller, and serve younger, more diverse and more deprived populations than traditional providers. Practices run by alternative providers performed worse than traditional providers on 15 of 17 indicators after adjusting for practice and population characteristics (p < 0.01 for all). Switching to a new alternative provider contract did not result in improved performance. Conclusions The introduction of new alternative providers to deliver primary care services in England has not led to improvements in quality and may have resulted in worse care. Regulators should ensure that new entrants to clinical provider markets are performing to adequate standards and at least as well as traditional providers. PMID:25908312

Performance of new alternative providers of primary care services in England: an observational study.

PubMed

Greaves, Felix; Laverty, Anthony A; Pape, Utz; Ratneswaren, Anenta; Majeed, Azeem; Millett, Christopher

2015-05-01

Health system reforms in England are opening broad areas of clinical practice to new providers of care. As part of these reforms, new entrants--including private companies--have been allowed into the primary care market under 'alternative provider of medical services' contracting mechanisms since 2004. The characteristics and performance of general practices working under new alternative provider contracts are not well described. We sought to compare the quality of care provided by new entrant providers to that provided by the traditional model of general practice. Open cohort study of English general practices. We used linear regression in cross-sectional and time series analyses, adjusting for practice and population characteristics, to compare quality in practices using alternative provider contracts to traditional practices. We created regression models using practice fixed effects to estimate the impact of practices changing to the new contract type. The English National Health Service. All general practices open from 2008/2009 to 2012/2013. Seventeen established quality indicators--covering clinical effectiveness, efficiency, access and patient experience. In total, 4.1% (347 of 8300) of general practices in England were run by alternative contract providers. These practices tended to be smaller, and serve younger, more diverse and more deprived populations than traditional providers. Practices run by alternative providers performed worse than traditional providers on 15 of 17 indicators after adjusting for practice and population characteristics (p < 0.01 for all). Switching to a new alternative provider contract did not result in improved performance. The introduction of new alternative providers to deliver primary care services in England has not led to improvements in quality and may have resulted in worse care. Regulators should ensure that new entrants to clinical provider markets are performing to adequate standards and at least as well as traditional providers. © The Royal Society of Medicine.

Open Source Initiative Powers Real-Time Data Streams

NASA Technical Reports Server (NTRS)

2014-01-01

Under an SBIR contract with Dryden Flight Research Center, Creare Inc. developed a data collection tool called the Ring Buffered Network Bus. The technology has now been released under an open source license and is hosted by the Open Source DataTurbine Initiative. DataTurbine allows anyone to stream live data from sensors, labs, cameras, ocean buoys, cell phones, and more.

Long-timescale molecular dynamics simulations elucidate the dynamics and kinetics of exposure of the hydrophobic patch in troponin C.

PubMed

Lindert, Steffen; Kekenes-Huskey, Peter M; McCammon, J Andrew

2012-10-17

Troponin (Tn) is an important regulatory protein in the thin-filament complex of cardiomyocytes. Calcium binding to the troponin C (TnC) subunit causes a change in its dynamics that leads to the transient opening of a hydrophobic patch on TnC's surface, to which a helix of another subunit, troponin I (TnI), binds. This process initiates contraction, making it an important target for studies investigating the detailed molecular processes that underlie contraction. Here we use microsecond-timescale Anton molecular dynamics simulations to investigate the dynamics and kinetics of the opening transition of the TnC hydrophobic patch. Free-energy differences for opening are calculated for wild-type Ca(2+)-bound TnC (∼8 kcal/mol), V44Q Ca(2+)-bound TnC (3.2 kcal/mol), E40A Ca(2+)-bound TnC (∼12 kcal/mol), and wild-type apo TnC (∼20 kcal/mol). These results suggest that the mutations have a profound impact on the frequency with which the hydrophobic patch presents to TnI. In addition, these simulations corroborate that cardiac wild-type TnC does not open on timescales relevant to contraction without calcium being bound. Copyright © 2012 Biophysical Society. Published by Elsevier Inc. All rights reserved.

Parallel NGO networks for HIV control: risks and opportunities for NGO contracting.

PubMed

Zaidi, Shehla; Gul, Xaher; Nishtar, Noureen Aleem

2012-12-27

Policy measures for preventive and promotive services are increasingly reliant on contracting of NGOs. Contracting is a neo-liberal response relying on open market competition for service delivery tenders. In contracting of health services a common assumption is a monolithic NGO market. A case study of HIV control in Pakistan shows that in reality the NGO market comprises of parallel NGO networks having widely different service packages, approaches and agendas. These parallel networks had evolved over time due to vertical policy agendas. Contracting of NGOs for provision of HIV services was faced with uneven capacities and turf rivalries across both NGO networks. At the same time contracting helped NGO providers belonging to different clusters to move towards standardized service delivery for HIV prevention. Market based measures such as contracting need to be accompanied with wider policy measures that facilitate in bringing NGOs groups to a shared understanding of health issues and responses.

Blood-Brain Barrier Closure Time After Controlled Ultrasound-Induced Opening Is Independent of Opening Volume.

PubMed

O'Reilly, Meaghan A; Hough, Olivia; Hynynen, Kullervo

2017-03-01

Microbubble-mediated focused ultrasound (US) opening of the blood-brain barrier (BBB) has shown promising results for the treatment of brain tumors and conditions such as Alzheimer disease. Practical clinical implementation of focused US treatments would aim to treat a substantial portion of the brain; thus, the safety of opening large volumes must be investigated. This study investigated whether the opened volume affects the time for the BBB to be restored after treatment. Sprague Dawley rats (n = 5) received bilateral focused US treatments. One hemisphere received a single sonication, and the contralateral hemisphere was targeted with 4 overlapping foci. Contrast-enhanced T1-weighted magnetic resonance imaging was used to assess the integrity of the BBB at 0, 6, and 24 hours after focused US. At time 0, there was no significant difference in the mean enhancement between the single- and multi-point sonications (mean ± SD, 29.7% ± 18.4% versus 29.7% ± 24.1%; P = .9975). The mean cross-sectional area of the BBB opening resulting from the multi-point sonication was approximately 3.5-fold larger than that of the single-point case (14.2 ± 4.7 versus 4.1 ± 3.3 mm 2 ; P < .0001). The opened volumes in 9 of 10 hemispheres were closed by 6 hours after focused US. The remaining treatment location had substantially reduced enhancement at 6 hours and was closed by 24 hours. Histologic analysis revealed small morphologic changes associated with this location. T2-weighted images at 6 and 24 hours showed no signs of edema. T2*-weighted images obtained at 6 hours also showed no signs hemorrhage in any animal. The time for the BBB to close after focused US was independent of the opening volume on the time scale investigated. No differences in treatment effects were observable by magnetic resonance imaging follow-up between larger- and smaller-volume sonications, suggesting that larger-volume BBB opening can be performed safely. © 2017 by the American Institute of Ultrasound in Medicine.

Mars power system concept definition study. Volume 2: Appendices

NASA Technical Reports Server (NTRS)

Littman, Franklin D.

1994-01-01

This report documents the work performed by Rockwell International's Rocketdyne Division on NASA Contract No. NAS3-25808 (Task Order No. 16) entitled 'Mars Power System Definition Study'. This work was performed for NASA's Lewis Research Center (LeRC). The report is divided into two volumes as follows: Volume 1 - Study Results; and Volume 2 - Appendices. The results of the power system characterization studies, operations studies, and technology evaluations are summarized in Volume 1. The appendices include complete, standalone technology development plans for each candidate power system that was investigated.

Method and apparatus for electrokinetic transport

NASA Technical Reports Server (NTRS)

James, Patrick Ismail (Inventor); Stejic, George (Inventor)

2012-01-01

Controlled electrokinetic transport of constituents of liquid media can be achieved by connecting at least two volumes containing liquid media with at least one dielectric medium with opposing dielectric surfaces in direct contact with said liquid media, and establishing at least one conduit across said dielectric medium, with a conduit inner surface surrounding a conduit volume and at least a first opening and a second opening opposite to the first opening. The conduit is arranged to connect two volumes containing liquid media and includes a set of at least three electrodes positioned in proximity of the inner conduit surface. A power supply is arranged to deliver energy to the electrodes such that time-varying potentials inside the conduit volume are established, where the superposition of said potentials represents at least one controllable traveling potential well that can travel between the opposing conduit openings.

Provider Experience and the Comparative Safety of Laparoscopic and Open Colectomy.

PubMed

Sheetz, Kyle H; Norton, Edward C; Birkmeyer, John D; Dimick, Justin B

2017-02-01

To evaluate the comparative safety of laparoscopic and open colectomy across surgeons varying in experience with laparoscopy. National Medicare data (2008-2010) for beneficiaries undergoing laparoscopic or open colectomy. Using instrumental variable methods to address selection bias, we evaluated outcomes of laparoscopic and open colectomy. Our instrument was the regional use of laparoscopy in the year prior to a patient's operation. We then evaluated outcomes stratified by surgeons' annual volume of laparoscopic colectomy. Laparoscopic colectomy was associated with lower mortality (OR: 0.75, 95 percent CI: 0.70-0.78) and fewer complications than open surgery (OR: 0.82, 95 percent CI: 0.79-0.85). Increasing surgeon volume was associated with better outcomes for both procedures, but the relationship was stronger for laparoscopy. The comparative safety depended on surgeon volume. High-volume surgeons had 40 percent lower mortality (OR: 0.60, 95 percent CI: 0.55-0.65) and 30 percent fewer complications (OR: 0.70, 95 percent CI: 0.67-0.74) with laparoscopy. Conversely, low-volume surgeons had 7 percent higher mortality (OR: 1.07, 95 percent CI: 1.02-1.13) and 18 percent more complications (OR: 1.18, 95 percent CI: 1.12-1.24) with laparoscopy. This population-based study demonstrates that the comparative safety of laparoscopic and open colectomy is influenced by surgeon volume. Laparoscopic colectomy is only safer for patients whose surgeons have sufficient experience. © Health Research and Educational Trust.

A structural model of age, grey matter volumes, education, and personality traits.

PubMed

Kitamura, Soichiro; Yasuno, Fumihiko; Yamamoto, Akihide; Kazui, Hiroaki; Kudo, Takashi; Matsuoka, Kiwamu; Kiuchi, Kuniaki; Kosaka, Jun; Nagatsuka, Kazuyuki; Iida, Hidehiro; Kishimoto, Toshifumi

2016-01-01

When the relationship between ageing and changes in personality traits is considered, it is important to know how they are influenced by biological and environmental factors. The present study examined the relationships between various factors associated with the effect of ageing on personality traits, including structural changes of the brain and environmental factors such as education. We recruited 41 healthy subjects. We administered the NEO Five-Factor Inventory to assess personality factors. Magnetic resonance imaging was performed, and regional grey matter (GM) volumes were obtained. We identified associations in the correlation analysis of age, cerebral GM volume, years of education, and the personality trait of openness. Path analysis was used to estimate the relationships among these factors. The path analysis model of age, GM volume, years of education, and the personality trait of openness revealed that age has an indirect negative association with openness through GM volume and years of education. Ageing was related to a decrease in GM volume, which was in turn related to a decrease in the openness score. Older subjects generally had fewer years of education, which was related to a lower openness score. Maintaining openness against the effects of ageing is desirable, and our results imply that interventions against age-related cerebral atrophy and the promotion of opportunities for higher education may contribute to the development and stability of a healthy personality during the adult life course. © 2015 The Authors. Psychogeriatrics © 2015 Japanese Psychogeriatric Society.

PHYSICAL MODELING OF CONTRACTED FLOW.

USGS Publications Warehouse

Lee, Jonathan K.

1987-01-01

Experiments on steady flow over uniform grass roughness through centered single-opening contractions were conducted in the Flood Plain Simulation Facility at the U. S. Geological Survey's Gulf Coast Hydroscience Center near Bay St. Louis, Miss. The experimental series was designed to provide data for calibrating and verifying two-dimensional, vertically averaged surface-water flow models used to simulate flow through openings in highway embankments across inundated flood plains. Water-surface elevations, point velocities, and vertical velocity profiles were obtained at selected locations for design discharges ranging from 50 to 210 cfs. Examples of observed water-surface elevations and velocity magnitudes at basin cross-sections are presented.

The determinants of transverse tubular volume in resting skeletal muscle

PubMed Central

Sim, Jingwei; Fraser, James A

2014-01-01

The transverse tubular (t)-system of skeletal muscle couples sarcolemmal electrical excitation with contraction deep within the fibre. Exercise, pathology and the composition of the extracellular fluid (ECF) can alter t-system volume (t-volume). T-volume changes are thought to contribute to fatigue, rhabdomyolysis and disruption of excitation–contraction coupling. However, mechanisms that underlie t-volume changes are poorly understood. A multicompartment, history-independent computer model of rat skeletal muscle was developed to define the minimum conditions for t-volume stability. It was found that the t-system tends to swell due to net ionic fluxes from the ECF across the access resistance. However, a stable t-volume is possible when this is offset by a net efflux from the t-system to the cell and thence to the ECF, forming a net ion cycle ECF→t-system→sarcoplasm→ECF that ultimately depends on Na+/K+-ATPase activity. Membrane properties that maximize this circuit flux decrease t-volume, including PNa(t) > PNa(s), PK(t) < PK(s) and N(t) < N(s) [P, permeability; N, Na+/K+-ATPase density; (t), t-system membrane; (s), sarcolemma]. Hydrostatic pressures, fixed charges and/or osmoles in the t-system can influence the magnitude of t-volume changes that result from alterations in this circuit flux. Using a parameter set derived from literature values where possible, this novel theory of t-volume was tested against data from previous experiments where t-volume was measured during manipulations of ECF composition. Predicted t-volume changes correlated satisfactorily. The present work provides a robust, unifying theoretical framework for understanding the determinants of t-volume. PMID:25384782

APA Handbook of Industrial and Organizational Psychology. Three-Volume Set--Volume 1: Building and Developing the Organization. Volume 2: Selecting and Developing Members for the Organization. Volume 3: Maintaining, Expanding, and Contracting the Organization. APA Handbooks in Psychology Series. APA Reference Books Collection

ERIC Educational Resources Information Center

Zedeck, Sheldon, Ed.

2011-01-01

APA Books® announces the "APA Handbook of Industrial and Organizational Psychology"--the first offering in an new reference series covering core and emerging subdisciplines, the "APA Handbooks in Psychology." I/O Psychology is both a science/practice and an applied/basic research discipline. Appropriately, the "APA…

The Blood Volume of the Guinea Pig: Effects of Epinephrine and Isoproterenol upon the Red Cell and Plasma Volumes, Heart Rate, and Mean Arterial Pressure,

DTIC Science & Technology

1987-09-01

capillaries (4), blood volumes calculated from plasma volume measures must correct for label that has left the system between the time of the injected dose...Splenic sequestration and contraction are mediated by the autonomic nervous system and blood-borne agents (10). Sympathetic nerve fibers from the truncus...sympathlcus and parasympathetic neurons of the nervus vagus (cranial nerve X) innervate the celiac plexus (8, 11). A subdivision of the celiac plexus

Report: NCLB Law Hasn't Superseded Contracts

ERIC Educational Resources Information Center

Keller, Bess

2006-01-01

The possibility that the No Child Left Behind Act could trump provisions of collective bargaining agreements with teachers has hung in the air as an open question since before the measure became law in 2002. But it should not anymore, says a report released last week asserting that the teachers' contracts have the winning hand. The debate began as…

The perfused swine uterus model: long-term perfusion

PubMed Central

2012-01-01

Background It has previously been shown that the viability of swine uteri can be maintained within the physiological range in an open perfusion model for up to 8 hours. The aim of this study was to assess medium- to long-term perfusion of swine uteri using a modified Krebs–Ringer bicarbonate buffer solution (KRBB) in the established open perfusion model. Methods In an experimental study at an infertility institute, 30 swine uteri were perfused: group 1: n = 11, KRBB; group 2: n = 8, modified KRBB with drainage of perfusate supernatant; group 3: n = 11, modified KRBB with drainage of perfusate every 2 h and substitution with fresh medium. Modified and conventional KRBB were compared with regard to survival and contraction parameters: intrauterine pressure (IUP), area under the curve (AUC), and frequency of contractions (F). Results Modified KRBB showed significantly higher IUP, AUC, and F values than perfusion with conventional KRBB. In group 3, the organ survival time of up to 17 h, with a 98% rate of effective contraction time, differed significantly from group 1 (P < 0.001). Conclusions Using modified KRBB in combination with perfusate substitution improves the open model for perfusion of swine uteri with regard to survival time and quality of contraction parameters. This model can be used for medium- to long-term perfusion of swine uteri, allowing further metabolic ex vivo studies in a cost-effective way and with little logistic effort. PMID:23241226

The relationship between hippocampal volume and static postural sway: results from the GAIT study.

PubMed

Beauchet, Olivier; Barden, John; Liu-Ambrose, Teresa; Chester, Victoria L; Szturm, Tony; Allali, Gilles

2016-02-01

The role of the hippocampus in postural control, in particular in maintaining upright stance, has not been fully examined in normal aging. This study aims to examine the association of postural sway with hippocampal volume while maintaining upright stance in healthy older individuals. Seventy healthy individuals (mean age 69.7 ± 3.4 years; 41.4 % women) were recruited in this study based on cross-sectional design. Hippocampal volume (quantified from a three-dimensional T1-weighted MRI using semi-automated software), three center of pressure (COP) motion parameters (sway area, path length of anterior-posterior (AP) and medial-lateral (ML) displacement) while maintaining upright stance (eyes open and closed), and the relative difference between open and closed eye conditions were used as outcome measures. Age, sex, body mass index, lower limb proprioception, distance vision, 15-item geriatric depression scale score, total cranial volume, and white matter abnormalities were used as covariates. The sway area decreased from open to closed eye condition but this variation was non-significant (P = 0.244), whereas path length of AP and ML displacement increased significantly (P < 0.003). Increase in sway area from open to closed eyes was associated with greater hippocampal volume (β -18.21; P = 0.044), and a trend for an association of increase in path length of AP displacement (P = 0.075 for open eyes and P = 0.071 for closed eyes) with greater hippocampal volume was reported. The hippocampus is involved in upright postural control in normal aging, such that an increase in sway area of COP motion from open to closed eyes is associated with greater hippocampal volume in healthy older adults.

Contract Attorneys Course Deskbook. Volume 1

DTIC Science & Technology

2007-06-21

sources ; exceptions,” deletes “specialty metals ” from the listed items in § 2533a and creates a whole new section to address specialty metals . The...Acquisition Procedures 11 Commercial Item Acquisitions 12 Contract Pricing 13 Bid Protests 14 Competitive Sourcing ii 15...Requirements Part 7: Acquisition Planning Part 8: Required Sources of Supplies and Services Part 9: Contractor Qualifications Part 10: Market

The Colleges and the Courts: Faculty and Staff before the Bench. Updating Supplement.

ERIC Educational Resources Information Center

Chambers, M. M.

This document is an updating supplement to a 1973 volume of the same title and is intended to cover the various aspects of court action effecting higher education, and particularly the faculty and staff for the period 1973-76. The areas discussed include the inception of contracts; due process in nonrenewal of nontenure contracts and probationary…

Australian DefenceScience. Volume 12, Number 3, Spring

DTIC Science & Technology

2004-01-01

Australian DEFENCESCIENCE Spring Issue Volume 12 Number 3 2004 Autonomous UAV flight a world first Missile countermeasures – from flares to lasers...4. TITLE AND SUBTITLE Australian DefenceScience. Volume 12 , Number 3 5a. CONTRACT NUMBER 5b. GRANT NUMBER 5c. PROGRAM ELEMENT NUMBER 6. AUTHOR(S...ADDRESS(ES) 10. SPONSOR/MONITOR’S ACRONYM(S) 11. SPONSOR/MONITOR’S REPORT NUMBER(S) 12 . DISTRIBUTION/AVAILABILITY STATEMENT Approved for public

Using Photogrammetry to Estimate Tank Waste Volumes from Video

DOE Office of Scientific and Technical Information (OSTI.GOV)

Field, Jim G.

Washington River Protection Solutions (WRPS) contracted with HiLine Engineering & Fabrication, Inc. to assess the accuracy of photogrammetry tools as compared to video Camera/CAD Modeling System (CCMS) estimates. This test report documents the results of using photogrammetry to estimate the volume of waste in tank 241-C-I04 from post-retrieval videos and results using photogrammetry to estimate the volume of waste piles in the CCMS test video.

Analysis of Factors That Have Influenced Outcomes of Battles and Wars: A Data Base of Battles and Engagements. Volume 1. Main Report. Selected Battles 1600 - 1973.

DTIC Science & Technology

1984-09-01

Harms, Assistant Director for Management Support, and LT% Mike Deems, who was the Contracting Officer’s Representative for the HERO contract. COMMENTS...A1ND gJESTIONS may be directed to US Army Concep*s Aialysis Agency, ATTN: Assistint Director for Management Support, 8120 .uodriont Avenue, Bethesda...APPENDIX A STUDY CONTRIBUTORS 1. STUDY TEAM. Management and Support Directorate. Report Author: Lelma M. Harms Contract COTR: LTC J. M. Deems 2. EXTERNAL

78 FR 20422 - Boards and Committees

Federal Register 2010, 2011, 2012, 2013, 2014

2013-04-05

... be accessed on the Agency's open Government Web site at http://www.nasa.gov/open/ . DATES: This... NATIONAL AERONAUTICS AND SPACE ADMINISTRATION 14 CFR Part 1209 [Docket No. NASA-2013-0001] RIN... referenced in NASA's Contract Adjustment Board rule. The revision to this rule is part of NASA's...

Rigor mortis at the myocardium investigated by post-mortem magnetic resonance imaging.

PubMed

Bonzon, Jérôme; Schön, Corinna A; Schwendener, Nicole; Zech, Wolf-Dieter; Kara, Levent; Persson, Anders; Jackowski, Christian

2015-12-01

Post-mortem cardiac MR exams present with different contraction appearances of the left ventricle in cardiac short axis images. It was hypothesized that the grade of post-mortem contraction may be related to the post-mortem interval (PMI) or cause of death and a phenomenon caused by internal rigor mortis that may give further insights in the circumstances of death. The cardiac contraction grade was investigated in 71 post-mortem cardiac MR exams (mean age at death 52 y, range 12-89 y; 48 males, 23 females). In cardiac short axis images the left ventricular lumen volume as well as the left ventricular myocardial volume were assessed by manual segmentation. The quotient of both (LVQ) represents the grade of myocardial contraction. LVQ was correlated to the PMI, sex, age, cardiac weight, body mass and height, cause of death and pericardial tamponade when present. In cardiac causes of death a separate correlation was investigated for acute myocardial infarction cases and arrhythmic deaths. LVQ values ranged from 1.99 (maximum dilatation) to 42.91 (maximum contraction) with a mean of 15.13. LVQ decreased slightly with increasing PMI, however without significant correlation. Pericardial tamponade positively correlated with higher LVQ values. Variables such as sex, age, body mass and height, cardiac weight and cause of death did not correlate with LVQ values. There was no difference in LVQ values for myocardial infarction without tamponade and arrhythmic deaths. Based on the observation in our investigated cases, the phenomenon of post-mortem myocardial contraction cannot be explained by the influence of the investigated variables, except for pericardial tamponade cases. Further research addressing post-mortem myocardial contraction has to focus on other, less obvious factors, which may influence the early post-mortem phase too. Copyright © 2015 Elsevier Ireland Ltd. All rights reserved.

Option contracts for allocating water in inter-basin transfers: the case of the Tagus-Segura Transfer in Spain

NASA Astrophysics Data System (ADS)

Rey, Dolores; Garrido, Alberto; Calatraba, Javier

2014-05-01

Users in the Mediterranean region face significant water supply risks. Water markets mechanisms can provide flexibility to water systems run in tight situations. The largest water infrastructure in the Iberian Peninsula connects the Segura and Tagus Basins. Stakeholders and politicians in the Tagus Basin have asked that water transfers between the two basins be eventually phased out. The need to increase the statutory minimum environmental flow in the middle Tagus and to meet new urban demands is going to result in a redefinition of the Transfer's management rules, leading to a reduction in the transferable volumes. To minimise the consequences of such restrictions to irrigators in the Segura Basin who depend on the transferred volumes, we propose the establishment of water option contracts between both basins that represents an institutional innovation with respect to previous inter-basin spot market experiences. Based on the draft of the new Tagus Basin Plan, we propose both a modification of the Transfer's management rule and an innovative inter-basin option contract. The main goal of the paper is to define this contract and evaluate it with respect to non-market scenarios. We also assess the resulting impact on environmental flows in the Tagus River and water availability for users in the Segura Basin, together with the economic impacts of such contract on both basins. Our results show that the proposed option contract would reduce the impact of a change in the transfer's management rule, and reduce the supply risks of the recipient area. Keywords: environmental flow, inter-basin transfer, option contracts, Tagus-Segura, water markets, water supply reliability.

Advanced transportation system studies. Technical area 2: Heavy lift launch vehicle development. Volume 2; Technical Results

NASA Technical Reports Server (NTRS)

1995-01-01

Sections 10 to 13 of the Advanced Transportation System Studies final report are included in this volume. Section 10 contains a copy of an executive summary that was prepared by Lockheed Space Operations Company (LSOC) to document their support to the TA-2 contract during the first-year period of performance of the contract, May 1992 through May 1993. LSOC participated on the TA-2 contract as part of the concurrent engineering launch system definition team, and provided outstanding heavy lift launch vehicle (HLLV) ground operations requirements and concept assessments for Lockheed Missiles and Space Company (LMSC) through an intercompany work transfer as well as providing specific HLLV ground operations assessments at the direction of NASA KSC through KSC funding that was routed to the TA-2 contract. Section 11 contains a copy of a vehicle-independent, launch system health management requirements assessment. The purpose of the assessment was to define both health management requirements and the associated interfaces between a generic advanced transportation system launch vehicle and all related elements of the entire transportation system, including the ground segment. Section 12 presents the major TA-2 presentations provided to summarize the significant results and conclusions that were developed over the course of the contract. Finally, Section 13 presents the design and assessment report on the first lunar outpost heavy lift launch vehicle.

Use of an Assistant Surgeon Does not Mitigate the Effect of Lead Surgeon Volume on Outcomes Following Open Repair of Intact Abdominal Aortic Aneurysms.

PubMed

Deery, Sarah E; O'Donnell, Thomas F X; Zettervall, Sara L; Darling, Jeremy D; Shean, Katie E; O'Malley, A James; Landon, Bruce E; Schermerhorn, Marc L

2018-05-01

While higher lead surgeon volume has been associated with lower mortality following open abdominal aortic aneurysm (AAA) repair, little is known about the impact of using an attending surgeon as assistant surgeon. The aim of this study was to determine whether the presence of an assistant surgeon, particularly a high volume assistant, mitigates the relationship between lead surgeon volume and outcomes. All Medicare beneficiaries who underwent intact, open AAA repair between 2003 and 2008 were evaluated and nested regression models were constructed to evaluate the relationship between surgeon and assistant volume and peri-operative mortality, adjusting for comorbid conditions and hospital volume. In total 28,590 repairs were studied, of which 19,284 (67.5%) were performed by a single surgeon and 9306 (32.5%) included an assistant surgeon. Of cases with an assistant, 12.3% included a high volume assistant surgeon. Lower volume surgeons more frequently used an assistant (lead surgeon Q1 volume: 40%; Q2: 36%; Q3: 34%; Q4: 29%; Q5: 27% [p < .01]). In cases with no assistant, adjusted peri-operative mortality varied monotonically with surgeon volume (Q1: 4.7%; Q2: 4.4%; Q3: 4.1%; Q4: 3.3%; Q5: 3.2%). However, the use of a high or a low volume assistant surgeon, compared with no attending surgeon as assistant, was not associated with lower peri-operative mortality in any lead surgeon volume quintile, even among those operations performed by the lowest volume lead surgeons. Employing an assistant surgeon does not improve outcomes amongst any quintile of volume of the lead surgeon. As surgeons perform fewer open AAA repairs in the modern era, these data imply that even the help of a high volume assistant surgeon may not mitigate the detrimental effect of a lower volume surgeon. Copyright © 2018 European Society for Vascular Surgery. Published by Elsevier B.V. All rights reserved.

Development of an Evaporation Sub-model and Simulation of Multiple Droplet Impingement in Volume of Fluid Method

NASA Astrophysics Data System (ADS)

Potham, Sathya Prasad

Droplet collision and impingement on a substrate are widely observed phenomenon in many applications like spray injection of Internal Combustion Engines, spray cooling, spray painting and atomizers used in propulsion applications. Existing Lagrangian models do not provide a comprehensive picture of the outcome of these events and may involve model constants requiring experimental data for validation. Physics based models like Volume of Fluid (VOF) method involve no parametric tuning and are more accurate. The aim of this thesis is to extend the basic VOF method with an evaporation sub-model and implement in an open source Computational Fluid Dynamics (CFD) software, OpenFOAM. The new model is applied to numerically study the evaporation of spherical n-heptane droplets impinging on a hot wall at atmospheric pressure and a temperature above the Leidenfrost temperature. An additional vapor phase is introduced apart from the liquid and gas phases to understand the mixing and diffusion of vapor and gas phases. The evaporation model is validated quantitatively and qualitatively with fundamental problems having analytical solutions and published results. The effect of droplet number and arrangement on evaporation is studied by three cases with one (Case 1), two (Case 2) and four (Case 3) droplets impinging on hot wall in film boiling regime at a fixed temperature of wall and a constant non-dimensional distance between droplets. Droplet lift and spread, surface temperature, heat transfer, and evaporation rate are examined. It was observed that more liquid mass evaporated in Case 1 compared to the other cases. Droplet levitation begins early in Case 1 and very high levitation observed was partially due to contraction of its shape from elongated to a more circular form. Average surface temperature was also considerably reduced in Case 1 due to high droplet levitation.

The contribution of volume, technique, and load to single-repetition and total-repetition kinematics and kinetics in response to three loading schemes.

PubMed

Crewther, Blair T; Cronin, John; Keogh, Justin W L

2008-11-01

This study examined the effect of volume, technique, and load upon single-repetition and total-repetition kinematics and kinetics during three loading schemes. Eleven recreationally trained males each performed a power (8 sets of 6 repetitions at 45% of one-repetition maximum [1RM], 3-minute rest periods, explosive and ballistic movements), hypertrophy (10 sets of 10 repetitions at 75% 1RM, 2-minute rest periods, controlled movements), and maximal strength (6 sets of 4 repetitions at 88% 1RM, 4-minute rest periods, explosive intent) scheme involving squats. Examination of repetition data showed that load intensity (% 1RM) generally had a direct effect on forces, contraction times, impulses, and work (i.e., increasing with load), whereas power varied across loads (p < 0.001). However, total-repetition forces, contraction times, impulses, work, and power were all greater in the hypertrophy scheme (p < 0.001), because of the greater number of repetitions performed (volume) as well as lifting technique. No differences in total forces were found between the equal-volume power and maximal strength schemes, but the former did produce greater total contraction times, work, and power (p < 0.001), which may also be attributed to repetition and technique differences. Total impulses were the only variable greater in the maximal strength scheme (p < 0.001). Thus, the interaction of load, volume, and technique plays an important role in determining the mechanical responses (stimuli) afforded by these workouts. These findings may explain disparities cited within research, regarding the effectiveness of different loading strategies for hypertrophy, maximal strength, and power adaptation.

Detrusor expulsive strength is preserved, but responsiveness to bladder filling and urinary sensitivity is diminished in the aging mouse

PubMed Central

DeAngelis, Anthony; Kuchel, George A.

2012-01-01

The prevalence of urinary symptoms increases with age and is a significant source of distress, morbidity, and expense in the elderly. Recent evidence suggests that symptoms in the aged may result from sensory dysfunction, rather than abnormalities of detrusor performance. Therefore, we employed a pressure/flow multichannel urethane-anesthetized mouse cystometry model to test the hypothesis that in vivo detrusor performance does not degrade with aging. Secondarily, we sought to evaluate sensory responsiveness to volume using pressure-volume data generated during bladder filling. Cystometric data from 2-, 12-, 22-, and 26-mo-old female C57BL6 mice were compared. All 2- and 12-mo-old mice, 66% of 22-mo-old mice, and 50% of 26-mo-old mice responded to continuous bladder filling with periodic reflex voiding. Abdominal wall contraction with voiding had a minimal contribution to expulsive pressure, whereas compliance pressure was a significant contributor. Maximum bladder pressure, estimated detrusor pressure, detrusor impulse (pressure-time integral), as well as indices of detrusor power and work, did not decrease with aging. Bladder precontraction pressures decreased, compliance increased, and nonvoiding contraction counts did not change with increasing age. Intervoid intervals, per-void volumes, and voiding flow rates increased with age. Calculations approximating wall stress during filling suggested loss of bladder volume sensitivity with increasing age. We conclude that aging is associated with an impaired ability to respond to the challenge of continuous bladder filling with cyclic voiding, yet among responsive animals, voiding detrusor contraction strength does not degrade with aging in this murine model. Furthermore, indirect measures suggest that bladder volume sensitivity is diminished. Thus, changes in homeostatic reserve and peripheral and/or central sensory mechanisms may be important contributors to aging-associated changes in bladder function. PMID:22204955

77 FR 8818 - Publication of FY 2011 Service Contract Inventory

Federal Register 2010, 2011, 2012, 2013, 2014

2012-02-15

... the inventory on the Bureau's Open Government homepage at the following link: http://www.consumerfinance.gov/open/ , specifically at http://www.consumerfinance.gov/wp-content/uploads/2012/01/Appendix-C-FY2011-Inventory-Data-Summary.pdf and http://www.consumerfinance.gov/wp-content/uploads/2012/01/Appendix...

41 CFR 60-1.3 - Definitions.

Code of Federal Regulations, 2011 CFR

2011-07-01

..., construction, transportation, research, insurance, and fund depository. The term Government contract does not.... (i) Example A: Contractor A posts on its web site an opening for a Mechanical Engineer position and... position. (ii) Example B: Contractor B posts on its web site an opening for the Accountant II position and...

41 CFR 60-1.3 - Definitions.

Code of Federal Regulations, 2014 CFR

2014-07-01

..., construction, transportation, research, insurance, and fund depository. The term Government contract does not.... (i) Example A: Contractor A posts on its web site an opening for a Mechanical Engineer position and... position. (ii) Example B: Contractor B posts on its web site an opening for the Accountant II position and...

41 CFR 60-1.3 - Definitions.

Code of Federal Regulations, 2010 CFR

2010-07-01

..., construction, transportation, research, insurance, and fund depository. The term Government contract does not.... (i) Example A: Contractor A posts on its web site an opening for a Mechanical Engineer position and... position. (ii) Example B: Contractor B posts on its web site an opening for the Accountant II position and...

41 CFR 60-1.3 - Definitions.

Code of Federal Regulations, 2013 CFR

2013-07-01

..., construction, transportation, research, insurance, and fund depository. The term Government contract does not.... (i) Example A: Contractor A posts on its web site an opening for a Mechanical Engineer position and... position. (ii) Example B: Contractor B posts on its web site an opening for the Accountant II position and...

41 CFR 60-1.3 - Definitions.

Code of Federal Regulations, 2012 CFR

2012-07-01

..., construction, transportation, research, insurance, and fund depository. The term Government contract does not.... (i) Example A: Contractor A posts on its web site an opening for a Mechanical Engineer position and... position. (ii) Example B: Contractor B posts on its web site an opening for the Accountant II position and...

26 CFR 25.2512-6 - Valuation of certain life insurance and annuity contracts; valuation of shares in an open-end...

Code of Federal Regulations, 2011 CFR

2011-04-01

...) The fair market value of a share in an open-end investment company (commonly known as a “mutual fund... is a Saturday, Sunday, or holiday), the fair market value of the mutual fund share is the last public...

26 CFR 20.2031-8 - Valuation of certain life insurance and annuity contracts; valuation of shares in an open-end...

Code of Federal Regulations, 2011 CFR

2011-04-01

...) The fair market value of a share in an open-end investment company (commonly known as a “mutual fund..., or holiday), the fair market value of the mutual fund share is the last public redemption price...

17 CFR 1.3 - Definitions.

Code of Federal Regulations, 2012 CFR

2012-04-01

... concentrated orange juice, and all other goods and articles, except onions as provided in Pub. L. 85-839, and... futures commission merchant to margin, guarantee, or secure open foreign futures contracts plus or minus... or received, plus any other funds required to guarantee or secure open transactions plus or minus any...

Development of an animal model of nephrocalcinosis via selective dietary sodium and chloride depletion

PubMed Central

Tuchman, Shamir; Asico, Laureano D.; Escano, Crisanto; Bobb, Daniel A.; Ray, Patricio E.

2013-01-01

Background Nephrocalcinosis (NC) is an important clinical problem seen in critically ill pre-term neonates treated with loop diuretics. No reliable animal models are available to study the pathogenesis of NC in preterm infants. The purpose of this study was to develop a reproducible and clinically relevant animal model of NC for these patients, and to explore the impact of extracellular fluid (ECF) volume contraction induced by sodium and chloride depletion in this process. Methods Three-week old weanling Sprague-Dawley rats were fed diets deficient in either chloride or sodium and chloride. A sub-group of rats from each dietary group was injected daily with furosemide (40 mg/kg; i.p.). Results Rats fed a control diet, with or without furosemide, or a chloride depleted diet alone, did not develop NC. In contrast, 50% of the rats injected with furosemide and fed the chloride depleted diet developed NC. Moreover, 94% of the rats fed the combined sodium/chloride depleted diet developed NC, independently of furosemide use. NC was associated with the development of severe ECF volume contraction, hypochloremic, hypokalemic metabolic alkalosis, increased phosphaturia, and growth retardation. Conclusion Severe ECF volume contraction induced by chronic sodium and chloride depletion appears to play an important role in the pathogenesis of NC. PMID:23174703

Space station final study report. Volume 1: Executive summary

NASA Technical Reports Server (NTRS)

1987-01-01

Volume 1 of the Final Study Report provides an Executive Summary of the Phase B study effort conducted under contract NAS8-36526. Space station Phase B implementation resulted in the timely establishment of preliminary design tasks, including trades and analyses. A comprehensive summary of project activities in conducting this study effort is included.

Global pricing for cardiac care: hard lessons for physicians and hospitals.

PubMed

Goodroe, J H; Murphy, D A

1993-01-01

The challenges associated with global contracting are becoming apparent as more experience is gained. Contracts held by an open medical staff hospital provide an ever-changing equation. High-cost physicians can join the staff and alter the cost and quality outcomes that the hospital and physicians may anticipate. Also, physicians want to have assurances on how fee distribution is determined. For these reasons, some physicians are developing private contracting vehicles that assure their future. Managed competition is encouraging these creative models to respond to the market demands of payers; in some markets, these vehicles are creating the demand. It is important for both physicians and hospitals to be open to new creative models. Hospitals that insist on controlling the situation decrease its potential success. Flexibility ensures the ability of both entities to respond to new market demands. From the payer perspective, global contracting represents predictability of price and dependability of service. It encourages an economic relationship of dependence between a hospital and its physicians. Utilization of service is no longer the payers' problem; instead, the provider is asking the questions and managing the situation to assure that both quality and economic efficiency outcomes are achieved.

TU-A-12A-01: Consistency of Lung Expansion and Contraction During Respiration: Implications for Quantitative Imaging

DOE Office of Scientific and Technical Information (OSTI.GOV)

Patton, T; Du, K; Bayouth, J

Purpose: Four-dimensional computed tomography (4DCT) can be used to evaluate longitudinal changes in pulmonary function. The sensitivity of such measurements to identify function change may be improved with reproducible breathing patterns. The purpose of this study was to determine if inhale was more consistent than exhale, i.e., lung expansion during inhalation compared to lung contraction during exhalation. Methods: Repeat 4DCT image data acquired within a short time interval from 8 patients. Using a tissue volume preserving deformable image registration algorithm, Jacobian ventilation maps in two scanning sessions were computed and compared on the same coordinate for reproducibility analysis. Equivalent lungmore » volumes (ELV) were used for 5 subjects and equivalent title volumes (ETV) for the 3 subjects who experienced a baseline shift between scans. In addition, gamma pass rate was calculated from a modified gamma index evaluation between two ventilation maps, using acceptance criterions of 2mm distance-to-agreement and 5% ventilation difference. The gamma pass rates were then compared using paired t-test to determine if there was a significant difference. Results: Inhalation was more reproducible than exhalation. In the 5 ELV subjects 78.5% of the lung voxels met the gamma criteria for expansion during inhalation when comparing the two scans, while significantly fewer (70.9% of the lung voxels) met the gamma criteria for contraction during exhalation (p = .027). In the 8 total subjects analyzed the average gamma pass rate for expansion during inhalation was 75.2% while for contraction during exhalation it was 70.3%; which trended towards significant (p = .064). Conclusion: This work implies inhalation is more reproducible than exhalation, when equivalent respiratory volumes are considered. The reason for this difference is unknown. Longitudinal investigation of pulmonary function change based on inhalation images appears appropriate for Jacobian-based measure of lung tissue expansion. NIH Grant: R01 CA166703.« less

Feasibility of a Modified Chloramine Process for the Production of UDMH and MMH

DTIC Science & Technology

1978-08-31

that phase is provided in this report . Amine Fuels Production Feasibility Demonstration, MCR -75-466, Final Report and Addendurn I - Data Book, Martin ...Final Report , Martin Marietta Corporation, Denver (February 1976) Contract F04701-74-C-0039. Amine Fuels Production Feasibility Demonstration, MCF-75...466, CDRL A305, Volume I, Final Report ; Volume II Economic Analyses; and Volume III, Data Book; Martin Marietta Corporation, Denver (October 1976

Air Force Civil Engineer, Volume 12, Number 2, 2004

DTIC Science & Technology

2004-01-01

Volume 12 • No. 2 • 2004 CIVIL ENGINEERAir Force Report Documentation Page Form ApprovedOMB No. 0704-0188 Public reporting burden for the collection...Section: USAF Facility Energy Management Program. (Air Force Civil Engineer, Volume 12 , Number 02, 2004) 5a. CONTRACT NUMBER 5b. GRANT NUMBER 5c...AGENCY NAME(S) AND ADDRESS(ES) 10. SPONSOR/MONITOR’S ACRONYM(S) 11. SPONSOR/MONITOR’S REPORT NUMBER(S) 12 . DISTRIBUTION/AVAILABILITY STATEMENT

Air Force Civil Engineer, Volume 12, Number 1, 2004

DTIC Science & Technology

2004-01-01

Building the ARRK Volume 12 • No. 1 • 2004 Report Documentation Page Form ApprovedOMB No. 0704-0188 Public reporting burden for the collection of...Air Force Civil Engineer, Volume 12 , Number 01, 2004) 5a. CONTRACT NUMBER 5b. GRANT NUMBER 5c. PROGRAM ELEMENT NUMBER 6. AUTHOR(S) 5d. PROJECT...MONITOR’S ACRONYM(S) 11. SPONSOR/MONITOR’S REPORT NUMBER(S) 12 . DISTRIBUTION/AVAILABILITY STATEMENT Approved for public release; distribution

The Sortie-Generation Model System. Volume 5. Maintenance Subsystem

DTIC Science & Technology

1981-09-01

Compuger RoanutI f and moidel 11, Computer operatinS system 17, Proorammino largualviso IS. Numlier of .ugic proltsm Hoewl -3 CSCobol 600 stuscomentm...THE SORTIE-GENERATION MODEL SYSTEM OC’ VOLUME V MAINTENANCE SUBSYSTEM September 1981 Robert S. Greenberg 05$ Prepared pursuant to Department of...Generation Model System Volume V Maintenance Subsystem 6. PERFORMING ORG. REPORT NUMBER LMI Task- L102 7. AUTHOR(a) 8. CONTRACT OR GRANT NUMBER(a

Identifying Psychological Contract Breaches to Guide Improvements in Faculty Recruitment, Retention, and Development

PubMed Central

Desselle, Shane P.; Draugalis, JoLaine R.; Spies, Alan R.; Davis, Tamra S.; Bolino, Mark

2012-01-01

Objective. To identify pharmacy faculty members’ perceptions of psychological contract breaches that can be used to guide improvements in faculty recruitment, retention, and development. Methods. A list of psychological contract breaches was developed using a Delphi procedure involving a panel of experts assembled through purposive sampling. The Delphi consisted of 4 rounds, the first of which elicited examples of psychological contract breaches in an open-ended format. The ensuing 3 rounds consisting of a survey and anonymous feedback on aggregated group responses. Results. Usable responses were obtained from 11 of 12 faculty members who completed the Delphi procedure. The final list of psychological contract breaches included 27 items, after modifications based on participant feedback in subsequent rounds. Conclusion. The psychological contract breach items generated in this study provide guidance for colleges and schools of pharmacy regarding important aspects of faculty recruitment, retention, and development. PMID:22919084

Identifying psychological contract breaches to guide improvements in faculty recruitment, retention, and development.

PubMed

Peirce, Gretchen L; Desselle, Shane P; Draugalis, JoLaine R; Spies, Alan R; Davis, Tamra S; Bolino, Mark

2012-08-10

To identify pharmacy faculty members' perceptions of psychological contract breaches that can be used to guide improvements in faculty recruitment, retention, and development. A list of psychological contract breaches was developed using a Delphi procedure involving a panel of experts assembled through purposive sampling. The Delphi consisted of 4 rounds, the first of which elicited examples of psychological contract breaches in an open-ended format. The ensuing 3 rounds consisting of a survey and anonymous feedback on aggregated group responses. Usable responses were obtained from 11 of 12 faculty members who completed the Delphi procedure. The final list of psychological contract breaches included 27 items, after modifications based on participant feedback in subsequent rounds. The psychological contract breach items generated in this study provide guidance for colleges and schools of pharmacy regarding important aspects of faculty recruitment, retention, and development.

17 CFR 240.3a55-2 - Indexes underlying futures contracts trading for fewer than 30 days.

Code of Federal Regulations, 2010 CFR

2010-04-01

... 17 Commodity and Securities Exchanges 3 2010-04-01 2010-04-01 false Indexes underlying futures contracts trading for fewer than 30 days. 240.3a55-2 Section 240.3a55-2 Commodity and Securities Exchanges... of trading volume is reported in a currency other than U.S. dollars, the total value of each day's...

Costing Question Handling and ILL/Photocopying. A Study of Two State Contract Libraries in New Jersey. Volume II: Annexes.

ERIC Educational Resources Information Center

Robinson, Barbara M.

This report contains annex materials from a study conducted for the New Jersey State Library (NJSL) with two major objectives: (1) to determine how much it costs two state contract libraries--the Central Library of the Newark Public Library and the Bureau of Law and Reference of the New Jersey State Library--to provide supplemental question…

DSN Aperture Enhancement Project Office

NASA Technical Reports Server (NTRS)

Marina, Miguel

2012-01-01

All contracts are underway for antennas, associated facilities modifications and new transmitters. High risk CPI 100kW klystron and JPL high power uplink microwave components have been designed, prototyped and successfully tested at GDSCC to support the 80kW transmitter implementation and testing at vendor facility. Open issues, which might affect project delivery date, have plans in place or are being created, to maintain DSS-35 Operational Date. There are no known open issues that affect performance. Overall good progress has been made in all areas (procurements, contracts, design and development) and the project is confident that DSS-35 & 36 antennas and the three 80kW Uplink systems will be delivered according to plan.

Modified use of a dynamic bite opener--treatment and prevention of trismus in a child with head and neck cancer: a case report.

PubMed

Dijkstra, P U; Kropmans, T J; Tamminga, R Y

1992-10-01

Trismus may be a complication arising during or after treatment of patients with head and neck cancer. Treatment of trismus is difficult, making prevention very important. To prevent and treat trismus in a patient with a nasopharyngeal tumor, the Contract-Relax-Antagonist-Contract (CRAC) technique was applied, with the aid of a custom-made dynamic bite opener (DBO). The CRAC technique in combination with the DBO, as a therapy/prevention program for trismus, is not referred to in the literature. The combination of CRAC and DBO appeared to be a gentle and effective method well tolerated by the patient.

Muscle oxygenation of vastus lateralis and medialis muscles during alternating and pulsed current electrical stimulation.

PubMed

Aldayel, Abdulaziz; Muthalib, Makii; Jubeau, Marc; McGuigan, Michael; Nosaka, Kazunori

2011-05-01

This study compared between alternating and pulsed current electrical muscle stimulation (EMS) for muscle oxygenation and blood volume during isometric contractions. Nine healthy men (23-48 years) received alternating current EMS (2500 Hz) modulated at 75 Hz on the knee extensors of one leg, and pulsed current EMS (75 Hz) for the other leg separated by 2 weeks in a randomised, counter-balanced order. Pulse duration (400 μs), on-off ratio (5-15 s) and other stimulation parameters were matched between conditions and 30 isometric contractions were induced at the knee joint angle of 100° (0° full extension). Changes in tissue oxygenation index (∆TOI) and total hemoglobin volume (∆tHb) of vastus lateralis and medialis muscles over 30 contractions were assessed by a near-infrared spectroscopy, and were compared between conditions by a two-way repeated measures ANOVA. Peak torque produced during EMS increased over 30 contractions in response to the increase in the stimulation intensity for pulsed current, but not for the alternating current EMS. The torque during each isometric contraction was less stable in alternating than pulsed current EMS. The changes in ∆TOI amplitude during relaxation phases and ∆tHb amplitude were not significantly different between conditions. However, the decreases in ∆TOI amplitude during contraction phases from baseline were significantly (P < 0.05) greater for the pulsed current than alternating current from the 18th contraction (-15.6 ± 2.3 vs. -8.9 ± 1.8%) to 30th contraction (-10.7 ± 1.8 vs. -4.8 ± 1.5%). These results suggest that the muscles were less activated in the alternating current EMS when compared with the pulsed current EMS.

A rotating hot-wire technique for spatial sampling of disturbed and manipulated duct flows

NASA Technical Reports Server (NTRS)

Wark, C. E.; Nagib, H. M.; Jennings, M. J.

1990-01-01

A duct flow spatial sampling technique, in which an X-wire probe is rotated about the center of a cylindrical test section at a radius equal to one-half that of the test section in order to furnish nearly instantaneous multipoint measurements of the streamwise and azimuthal components, is presently evaluated in view of the control of flow disturbances downstream of various open inlet contractions. The effectiveness of a particular contraction in controlling ingested flow disturbances was ascertained by artificially introducing disturbances upstream of the contractions; control effectiveness if found to be strongly dependent on inlet contraction, with consequences for the reduction of passing-blade frequency noise during gas turbine engine ground testing.

ASTRONAUTICS INFORMATION OPEN LITERATURE SURVEY. VOLUME II. NO. 10 (Entries 22,871-23,094)

DOE Office of Scientific and Technical Information (OSTI.GOV)

None

1960-10-01

An open literature survey on astronautics is presented which covers the period of Oct. 1960. The material is organized alphabetically according to subject. A list of periodicals scanned is given in volume II No. 1-2 with addendums in subsequent volumes. Cumulative author and subject indexes are given at the end of the entries. (About 220 references.) (J.R.D.)

Parallel NGO Networks for HIV Control: Risks and Opportunities for NGO Contracting

PubMed Central

Zaidi, Shehla; Gul, Xaher; Nishtar, Noureen

2013-01-01

Policy measures for preventive and promotive services are increasingly reliant on contracting of NGOs. Contracting is a neo-liberal response relying on open market competition for service delivery tenders. In contracting of health services a common assumption is a monolithic NGO market. A case study of HIV control in Pakistan shows that in reality the NGO market comprises of parallel NGO networks having widely different service packages, approaches and agendas. These parallel networks had evolved over time due to vertical policy agendas. Contracting of NGOs for provision of HIV services was faced with uneven capacities and turf rivalries across both NGO networks. At the same time contracting helped NGO providers belonging to different clusters to move towards standardized service delivery for HIV prevention. Market based measures such as contracting need to be accompanied with wider policy and system measures that overcome silos in NGO working by facilitating a common construct on the health issue, cohesive priorities and integrated working. PMID:23445705

Commerical Remote Sensing Data Contract

USGS Publications Warehouse

,

2005-01-01

The U. S. Geological Survey's (USGS) Commercial Remote Sensing Data Contracts (CRSDCs) provide government agencies with access to a broad range of commercially available remotely sensed airborne and satellite data. These contracts were established to support The National Map partners, other Federal Civilian agency programs, and Department of Defense programs that require data for the United States and its territories. Experience shows that centralized procurement of remotely sensed data leads to considerable cost savings to the Federal government through volume discounts, reduction of redundant contract administrative costs, and avoidance of duplicate purchases. These contracts directly support the President's Commercial Remote Sensing Space Policy, signed in 2003, by providing a centralized mechanism for civil agencies to acquire commercial remote sensing products to support their mission needs in an efficient and coordinated way. CRSDC administration is provided by the USGS Mid-Continent Mapping Center in Rolla, Missouri.

Lung Function before and Two Days after Open-Heart Surgery.

PubMed

Urell, Charlotte; Westerdahl, Elisabeth; Hedenström, Hans; Janson, Christer; Emtner, Margareta

2012-01-01

Reduced lung volumes and atelectasis are common after open-heart surgery, and pronounced restrictive lung volume impairment has been found. The aim of this study was to investigate factors influencing lung volumes on the second postoperative day. Open-heart surgery patients (n = 107, 68 yrs, 80% male) performed spirometry both before surgery and on the second postoperative day. The factors influencing postoperative lung volumes and decrease in lung volumes were investigated with univariate and multivariate analyses. Associations between pain (measured by numeric rating scale) and decrease in postoperative lung volumes were calculated with Spearman rank correlation test. Lung volumes decreased by 50% and were less than 40% of the predictive values postoperatively. Patients with BMI >25 had lower postoperative inspiratory capacity (IC) (33 ± 14% pred.) than normal-weight patients (39 ± 15% pred.), (P = 0.04). More pain during mobilisation was associated with higher decreases in postoperative lung volumes (VC: r = 0.33, P = 0.001; FEV(1): r = 0.35, P ≤ 0.0001; IC: r = 0.25, P = 0.01). Patients with high BMI are a risk group for decreased postoperative lung volumes and should therefore receive extra attention during postoperative care. As pain is related to a larger decrease in postoperative lung volumes, optimal pain relief for the patients should be identified.

Lung Function before and Two Days after Open-Heart Surgery

PubMed Central

Urell, Charlotte; Westerdahl, Elisabeth; Hedenström, Hans; Janson, Christer; Emtner, Margareta

2012-01-01

Reduced lung volumes and atelectasis are common after open-heart surgery, and pronounced restrictive lung volume impairment has been found. The aim of this study was to investigate factors influencing lung volumes on the second postoperative day. Open-heart surgery patients (n = 107, 68 yrs, 80% male) performed spirometry both before surgery and on the second postoperative day. The factors influencing postoperative lung volumes and decrease in lung volumes were investigated with univariate and multivariate analyses. Associations between pain (measured by numeric rating scale) and decrease in postoperative lung volumes were calculated with Spearman rank correlation test. Lung volumes decreased by 50% and were less than 40% of the predictive values postoperatively. Patients with BMI >25 had lower postoperative inspiratory capacity (IC) (33 ± 14% pred.) than normal-weight patients (39 ± 15% pred.), (P = 0.04). More pain during mobilisation was associated with higher decreases in postoperative lung volumes (VC: r = 0.33, P = 0.001; FEV1: r = 0.35, P ≤ 0.0001; IC: r = 0.25, P = 0.01). Patients with high BMI are a risk group for decreased postoperative lung volumes and should therefore receive extra attention during postoperative care. As pain is related to a larger decrease in postoperative lung volumes, optimal pain relief for the patients should be identified. PMID:22924127

An arbitrary grid CFD algorithm for configuration aerodynamics analysis. Volume 1: Theory and validations

NASA Technical Reports Server (NTRS)

Baker, A. J.; Iannelli, G. S.; Manhardt, Paul D.; Orzechowski, J. A.

1993-01-01

This report documents the user input and output data requirements for the FEMNAS finite element Navier-Stokes code for real-gas simulations of external aerodynamics flowfields. This code was developed for the configuration aerodynamics branch of NASA ARC, under SBIR Phase 2 contract NAS2-124568 by Computational Mechanics Corporation (COMCO). This report is in two volumes. Volume 1 contains the theory for the derived finite element algorithm and describes the test cases used to validate the computer program described in the Volume 2 user guide.

An arbitrary grid CFD algorithm for configuration aerodynamics analysis. Volume 2: FEMNAS user guide

NASA Technical Reports Server (NTRS)

Manhardt, Paul D.; Orzechowski, J. A.; Baker, A. J.

1992-01-01

This report documents the user input and output data requirements for the FEMNAS finite element Navier-Stokes code for real-gas simulations of external aerodynamics flowfields. This code was developed for the configuration aerodynamics branch of NASA ARC, under SBIR Phase 2 contract NAS2-124568 by Computational Mechanics Corporation (COMCO). This report is in two volumes. Volume 1 contains the theory for the derived finite element algorithm and describes the test cases used to validate the computer program described in the Volume 2 user guide.

Financial constraints in capacity planning: a national utility regulatory model (NUREG). Volume III of III: software description. Final report

DOE Office of Scientific and Technical Information (OSTI.GOV)

None

1981-10-29

This volume is the software description for the National Utility Regulatory Model (NUREG). This is the third of three volumes provided by ICF under contract number DEAC-01-79EI-10579. These three volumes are: a manual describing the NUREG methodology; a users guide; and a description of the software. This manual describes the software which has been developed for NUREG. This includes a listing of the source modules. All computer code has been written in FORTRAN.

Temperature dependence of polyhedral cage volumes in clathrate hydrates

USGS Publications Warehouse

Chakoumakos, B.C.; Rawn, C.J.; Rondinone, A.J.; Stern, L.A.; Circone, S.; Kirby, S.H.; Ishii, Y.; Jones, C.Y.; Toby, B.H.

2003-01-01

The polyhedral cage volumes of structure I (sI) (carbon dioxide, methane, trimethylene oxide) and structure II (sII) (methane-ethane, propane, tetrahydrofuran, trimethylene oxide) hydrates are computed from atomic positions determined from neutron powder-diffraction data. The ideal structural formulas for sI and sII are, respectively, S2L6 ?? 46H2O and S16L???8 ?? 136H2O, where S denotes a polyhedral cage with 20 vertices, L a 24-cage, and L??? a 28-cage. The space-filling polyhedral cages are defined by the oxygen atoms of the hydrogen-bonded network of water molecules. Collectively, the mean cage volume ratio is 1.91 : 1.43 : 1 for the 28-cage : 24-cage : 20-cage, which correspond to equivalent sphere radii of 4.18, 3.79, and 3.37 A??, respectively. At 100 K, mean polyhedral volumes are 303.8, 227.8, and 158.8 A??3 for the 28-cage, 24-cage, and 20-cage, respectively. In general, the 20-cage volume for a sII is larger than that of a sI, although trimethylene oxide is an exception. The temperature dependence of the cage volumes reveals differences between apparently similar cages with similar occupants. In the case of trimethylene oxide hydrate, which forms both sI and sII, the 20-cages common to both structures contract quite differently. From 220 K, the sII 20-cage exhibits a smooth monotonic reduction in size, whereas the sI 20-cage initially expands upon cooling to 160 K, then contracts more rapidly to 10 K, and overall the sI 20-cage is larger than the sII 20-cage. The volumes of the large cages in both structures contract monotonically with decreasing temperature. These differences reflect reoriented motion of the trimethyelene oxide molecule in the 24-cage of sI, consistent with previous spectroscopic and calorimetric studies. For the 20-cages in methane hydrate (sI) and a mixed methane-ethane hydrate (sII), both containing methane as the guest molecule, the temperature dependence of the 20-cage volume in sII is much less than that in sI, but sII is overall larger in volume.

On 3-D inelastic analysis methods for hot section components. Volume 1: Special finite element models

NASA Technical Reports Server (NTRS)

Nakazawa, S.

1988-01-01

This annual status report presents the results of work performed during the fourth year of the 3-D Inelastic Analysis Methods for Hot Section Components program (NASA Contract NAS3-23697). The objective of the program is to produce a series of new computer codes permitting more accurate and efficient 3-D analysis of selected hot section components, i.e., combustor liners, turbine blades and turbine vanes. The computer codes embody a progression of math models and are streamlined to take advantage of geometrical features, loading conditions, and forms of material response that distinguish each group of selected components. Volume 1 of this report discusses the special finite element models developed during the fourth year of the contract.

Transformations of Heavy Metals and Plant Nutrients in Dredged Sediments as Affected by Oxidation Reduction Potential and pH. Volume 2. Materials and Methods/Results and Discussion

DTIC Science & Technology

1977-05-01

D )EGED IATWRAL WI0, 00 EEACHPRGAFT4- CONTRACT REPORT D -77-4 TRANSFORMATIONS OF HEAVY METALS AND PLANT NUTRIENTS IN DREDGED SEDIMENTS AS AFFECTED BY...Engineers, U. S. Army C=) Washington, D . C. 20314 Q-2 Under Contract No. DACW39-74-C-0076 CM-1 (DMRP Work Unit No. IC05) Monitored by Environmental...Sa70mB COMPLETING FOM T -IMPORT PUNIeRf oTACSINN ESCTLGNME Contract Report D -77-4GOTACSINN C NTSAAOGUMR RAAN SFORATIONS OFPEAV71ETALS AND

[A comparison between prostatic volume measured during suprapubic ultrasonography (TAUS) and volume of the enucleated gland after open prostatectomy].

PubMed

Szewczyk, Wojciech; Prajsner, Andrzej; Kozina, Janusz; Login, Tomasz; Kaczorowski, Marek

2004-01-01

General practitioner very often uses transabdominal ultrasonograpy (TAUS) in order to measure prostatic volume. Using this method it is rather impossible to distinguish between tissue of benign prostatic hyperplasia (BPH) and prostatic tissue which forms so called surgical capsule of BPH. The aim of this study was a comparison of prostatic volume measured during suprapubic (transabdominal) ultrasonography and volume of the enucleated gland after open prostatectomy. Regarding the results authors created a nomogram based on TAUS measurement of the prostate which helps to predict the volume of BPH. They also stated that surgical capsule of the BPH makes about 1/3 of the whole volume of the prostate measured by TAUS.

48 CFR 1609.7101-1 - Community-rated carrier incentive performance elements.

Code of Federal Regulations, 2010 CFR

2010-10-01

.... In order for information to be available to our customers in time for the annual Open Season... Open Season choices in selecting a health plan. In evaluating this item, the contracting officer will... officer will evaluate this item based on the carrier's ability to accept electronic data transmission from...

Maximum speed limits. Volume 4, An implementation method for setting a speed limit based on the 85th percentile speed

DOT National Transportation Integrated Search

1970-10-01

This volume contains an explanation of a method for setting a speed limit which was developed as a part of the project conducted by the Institute for Research in Public Safety under Contract No. FH-11-7275, "A Study for the Selection of Maximum Speed...

Long-lasting effect of a single botulinum toxin injection in the treatment of oropharyngeal dysphagia secondary to upper esophageal sphincter dysfunction: a pilot study.

PubMed

Terre, Rosa; Valles, Margarida; Panades, Agusti; Mearin, Fermin

2008-01-01

To evaluate the efficacy of botulinum toxin (BTX-A) injection in the cricopharyngeus muscle in patients with neurological dysphagia caused by alteration in the upper esophageal sphincter (UES) opening and with preserved pharyngeal contraction. A prospective pilot study was undertaken in 10 patients (7 brain lesions and 3 cervical spinal cord injuries), with a minimum time-lapse of 6 months from neurological lesion to BTX-A injection. Dysfunction of the UES opening and the presence of pharyngeal contraction were diagnosed by videofluoroscopy (VDF) and esophageal manometry (EM). The BTX-A (100 U) injection was guided by endoscopy. Clinical, VDF, and EM follow-ups were carried out at 3 weeks, 3 and 6 months, and at 1 year post-injection. Prior to treatment, 6 patients were fed by nasogastric tube. VDF showed impairment of the UES opening, residue in pyriform sinuses, and aspiration in all cases. During follow-up, there was a decrease in the number of patients that had aspiration: 3 patients at one year. During swallowing, EM showed a mean UES relaxation of 90% (range: 74.5-100%), residual pressure 3.2 mmHg (range: 0-13 mmHg) and pharyngeal amplitude 52 mmHg (range: 25-80 mmHg). At follow-up, a significant improvement in UES relaxation (98% (89-100%)) and pharyngeal contraction (97 mmHg (35-165 mmHg)) was observed. At 3 months, 6 patients were eating exclusively by mouth. One single injection of BTX-A in the UES has long-lasting effectiveness in patients with neurological dysphagia caused by alteration in the UES opening and with pharyngeal contraction. Nevertheless, a randomized control trial should be done to confirm these results and rule out the effect of potential spontaneous improvement of neurological injury.

26 CFR 25.2512-6 - Valuation of certain life insurance and annuity contracts; valuation of shares in an open-end...

Code of Federal Regulations, 2010 CFR

2010-04-01

... annuity. The value of the gift is the cost of the contract. Example (2). An annuitant purchased from a... Revenue INTERNAL REVENUE SERVICE, DEPARTMENT OF THE TREASURY (CONTINUED) ESTATE AND GIFT TAXES GIFT TAX; GIFTS MADE AFTER DECEMBER 31, 1954 Transfers § 25.2512-6 Valuation of certain life insurance and annuity...

Computer Program User’s Manual for FIREFINDER Digital Topographic Data Verification Library Dubbing System. Volume II. Dubbing.

DTIC Science & Technology

1982-01-29

N - Nw .VA COMPUTER PROGRAM USER’S MANUAL FOR . 0FIREFINDER DIGITAL TOPOGRAPHIC DATA VERIFICATION LIBRARY DUBBING SYSTEM VOLUME II DUBBING 29 JANUARY...Digital Topographic Data Verification Library Dubbing System, Volume II, Dubbing 6. PERFORMING ORG. REPORT NUMER 7. AUTHOR(q) S. CONTRACT OR GRANT...Software Library FIREFINDER Dubbing 20. ABSTRACT (Continue an revWee *Ide II necessary end identify by leek mauber) PThis manual describes the computer

Effects of a saw palmetto herbal blend in men with symptomatic benign prostatic hyperplasia.

PubMed

Marks, L S; Partin, A W; Epstein, J I; Tyler, V E; Simon, I; Macairan, M L; Chan, T L; Dorey, F J; Garris, J B; Veltri, R W; Santos, P B; Stonebrook, K A; deKernion, J B

2000-05-01

We tested the effects of a saw palmetto herbal blend in men with symptomatic benign prostatic hyperplasia (BPH) via a randomized, placebo controlled trial. We randomized 44 men 45 to 80 years old with symptomatic BPH into a trial of a saw palmetto herbal blend versus placebo. End points included routine clinical measures (symptom score, uroflowmetry and post-void residual urine volume), blood chemistry studies (prostate specific antigen, sex hormones and multiphasic analysis), prostate volumetrics by magnetic resonance imaging, and prostate biopsy for zonal tissue morphometry and semiquantitative histology studies. Saw palmetto herbal blend and placebo groups had improved clinical parameters with a slight advantage in the saw palmetto group (not statistically significant). Neither prostate specific antigen nor prostate volume changed from baseline. Prostate epithelial contraction was noted, especially in the transition zone, where percent epithelium decreased from 17.8% at baseline to 10.7% after 6 months of saw palmetto herbal blend (p <0.01). Histological studies showed that the percent of atrophic glands increased from 25. 2% to 40.9% after treatment with saw palmetto herbal blend (p <0.01). The mechanism of action appeared to be nonhormonal but it was not identified by tissue studies of apoptosis, cellular proliferation, angiogenesis, growth factors or androgen receptor expression. We noted no adverse effects of saw palmetto herbal blend. When the study was no longer blinded, 41 men elected to continue therapy in an open label extension. Saw palmetto herbal blend appears to be a safe, highly desirable option for men with moderately symptomatic BPH. The secondary outcome measures of clinical effect in our study were only slightly better for saw palmetto herbal blend than placebo (not statistically significant). However, saw palmetto herbal blend therapy was associated with epithelial contraction, especially in the transition zone (p <0.01), indicating a possible mechanism of action underlying the clinical significance detected in other studies.

Meteorological Error Budget Using Open Source Data

DTIC Science & Technology

2016-09-01

ARL-TR-7831 ● SEP 2016 US Army Research Laboratory Meteorological Error Budget Using Open- Source Data by J Cogan, J Smith, P...needed. Do not return it to the originator. ARL-TR-7831 ● SEP 2016 US Army Research Laboratory Meteorological Error Budget Using...Error Budget Using Open-Source Data 5a. CONTRACT NUMBER 5b. GRANT NUMBER 5c. PROGRAM ELEMENT NUMBER 6. AUTHOR(S) J Cogan, J Smith, P Haines

Analysis of Air Force Wartime Contracted Construction Project Performance

DTIC Science & Technology

2015-03-26

Management, Volume 140. Branconi, C. v. & Loch, C. H., 2004. Contracting for major projects: eight business levers for top management. International ...Problems X Material Supply Problems X Poor Owner Management X X Poor Contractor Management X Corruption and Bribery X The USACE survey...Kremers, et al., 2010; GAO, 2014; Thibault, 2011). The final difference, corruption and bribery , was mentioned in the USACE study as well as by Kremers

Defense Acquisition Research Journal. Volume 20, Number 3, Issue 67, October 2013

DTIC Science & Technology

2013-10-01

Contracting Operations (PZCO) FIGURE 4. CONTRACTING PHASE ZERO: PLAN, EXERCISE, REHEARSE, AND SYNCHRONIZE Note. BPA = Blanket Purchase Agreement; COCO...Construction Supplies; Oce Equipment; Quality of Life; and Morale, Welfare, and Recreation PO/TO/DO/ BPA Small Purchase Standard Vehicles PO/TO/DO/ BPA Small...Purchase Standard Vehicles PO/TO/DO/ BPA Small Purchase Standard Vehicles PO/TO/DO/ BPA Small Purchase Food, Water, Billeting, Hygiene; Transportation

Department of Defense Annual Statement of Assurance, Volume II for Fiscal Year 1996.

DTIC Science & Technology

1996-12-01

FY 1996. US Army Audit Agency (USAAA) conducted a multilocation audit of contract security requirements at the request of the US Army Contracting...corrective action(s) are certified by the responsible components upon completion and reviewed through on-site verification, subsequent audit . inspection...requirement for processing Navy pricing inquiries received by DLA inventory control points. 9/97 Verification: Subsequent on-site verification. audit

Structural correlates of Openness and Intellect: Implications for the contribution of personality to creativity.

PubMed

Vartanian, Oshin; Wertz, Christopher J; Flores, Ranee A; Beatty, Erin L; Smith, Ingrid; Blackler, Kristen; Lam, Quan; Jung, Rex E

2018-04-15

Openness/Intellect (i.e., openness to experience) is the Big Five personality factor most consistently associated with individual differences in creativity. Recent psychometric evidence has demonstrated that this factor consists of two distinct aspects-Intellect and Openness. Whereas Intellect reflects perceived intelligence and intellectual engagement, Openness reflects engagement with fantasy, perception, and aesthetics. We investigated the extent to which Openness and Intellect are associated with variations in brain structure as measured by cortical thickness, area, and volume (N = 185). Our results demonstrated that Openness was correlated inversely with cortical thickness and volume in left middle frontal gyrus (BA 6), middle temporal gyrus (MTG, BA 21), and superior temporal gyrus (BA 41), and exclusively with cortical thickness in left inferior parietal lobule (BA 40), right inferior frontal gyrus (IFG, BA 45), and MTG (BA 37). When age and sex were statistically controlled for, the inverse correlations between Openness and cortical thickness remained statistically significant for all regions except left MTG, whereas the correlations involving cortical volume remained statistically significant only for left middle frontal gyrus. There was no statistically significant correlation between Openness and cortical area, and no statistically significant correlation between Intellect and cortical thickness, area, or volume. Our results demonstrate that individual differences in Openness are correlated with variation in brain structure-particularly as indexed by cortical thickness. Given the involvement of the above regions in processes related to memory and cognitive control, we discuss the implications of our findings for the possible contribution of personality to creative cognition. © 2018 Her Majesty the Queen in Right of Canada 2018. Reproduced with permission of the Minister of Health, Canada. Human Brain Mapping.

Effects of different duration isometric contractions on tendon elasticity in human quadriceps muscles

PubMed Central

Kubo, Keitaro; Kanehisa, Hiroaki; Fukunaga, Tetsuo

2001-01-01

The present study aimed to investigate the influence of isometric training protocols with long- and short-duration contractions on the elasticity of human tendon structures in vivo. The elasticity was assessed through in vivo determination of the elongation (L) of the tendons and aponeuroses using ultrasonography, while the subjects performed ramp isometric exercise up to maximum voluntary contraction (MVC).Eight young males completed 12 weeks (4 days per week) of a unilateral isometric training programme on knee extensors, which consisted of two different combinations of contraction and relaxation times at 70 % MVC: one leg was trained using a short-duration protocol (3 sets of 50 repetitions of contraction for 1 s and relaxation for 2 s), and the other leg was trained using a long-duration protocol (4 sets of a combination of contraction for 20 s and relaxation for 1 min). The training volume per session, expressed as the integrated torque, was the same for the two protocols.Both protocols resulted in a significant increase in MVC: 31.8 ± 17.2 % for the short-duration protocol and 33.9 ± 14.4 % for the long-duration protocol. Moreover, the training produced significant increases in the muscle volume of the constituents of the quadriceps femoris, with similar relative gains for the two protocols: 7.4 ± 3.9 % for the short-duration protocol and 7.6 ± 4.3 % for the long-duration protocol.The short-duration protocol produced no significant change in L values at any of the force production levels. For the long-duration protocol, however, the L values above 550 N were significantly shorter after training. Analysis revealed that the group × test time interaction effect on tendon stiffness was significant. Stiffness increased significantly for the long-duration protocol, but not for the short-duration protocol.The present study demonstrates a greater increase in stiffness of human tendon structures following isometric training using longer duration contractions compared to shorter contractions. This suggests that the changes in the elasticity of the tendon structures after resistance training may be affected by the duration of muscle contraction. PMID:11600697

Space station Simulation Computer System (SCS) study for NASA/MSFC. Volume 5: Study analysis report

NASA Technical Reports Server (NTRS)

1989-01-01

The Simulation Computer System (SCS) is the computer hardware, software, and workstations that will support the Payload Training Complex (PTC) at the Marshall Space Flight Center (MSFC). The PTC will train the space station payload scientists, station scientists, and ground controllers to operate the wide variety of experiments that will be on-board the Freedom Space Station. The further analysis performed on the SCS study as part of task 2-Perform Studies and Parametric Analysis-of the SCS study contract is summarized. These analyses were performed to resolve open issues remaining after the completion of task 1, and the publishing of the SCS study issues report. The results of these studies provide inputs into SCS task 3-Develop and present SCS requirements, and SCS task 4-develop SCS conceptual designs. The purpose of these studies is to resolve the issues into usable requirements given the best available information at the time of the study. A list of all the SCS study issues is given.

Remote sensing data acquisition, analysis and archival. Volume 1. Final report

DOE Office of Scientific and Technical Information (OSTI.GOV)

Stringer, W.J.; Dean, K.G.; Groves, J.E.

1993-03-25

The project specialized in the acquisition and dissemination of satellite imagery and its utilization for case-specific and statistical analyses of offshore environmental conditions, particularly those involving sea ice. During the duration of this contract, 854 Landsat Multispectral Scanner and 2 Landsat Thematic Mapper scenes, 8,576 Advanced Very High Resolution Radiometer images, and 31,000 European, Earth Resources Satellite, Synthetic Aperture Radar images were archived. Direct assistance was provided to eight Minerals Management Service (MMS)-sponsored studies, including analyses of Port Moller circulation, Bowhead whale migration, distribution, population and behavioral studies, Beaufort Sea fisheries, oil spill trajectory model development, and Kasegaluk Lagoon environmentalmore » assessments. In addition, under this Cooperative Agreement several complete studies were undertaken based on analysis of satellite imagery. The topics included: Kasegaluk Lagoon transport, the effect of winter storms on arctic ice, the relationship between ice surface temperatures as measured by buoys and passive microwave imagery, unusual cloud forms following lead-openings, and analyses of Chukchi and Bering sea polynyas.« less

Inventory of Federal energy-related environment and safety research for FY 1978. Volume II. Project listings and indexes

DOE Office of Scientific and Technical Information (OSTI.GOV)

None

1979-12-01

This volume contains summaries of FY-1978 government-sponsored environment and safety research related to energy. Project summaries were collected by Aerospace Corporation under contract with the Department of Energy, Office of Program Coordination, under the Assistant Secretary for Environment. Summaries are arranged by log number, which groups the projects by reporting agency. The log number is a unique number assigned to each project from a block of numbers set aside for each agency. Information about the projects is included in the summary listings. This includes the project title, principal investigators, research organization, project number, contract number, supporting organization, funding level ifmore » known, related energy sources with numbers indicating percentages of effort devoted to each, and R and D categories. A brief description of each project is given, and this is followed by subject index terms that were assigned for computer searching and for generating the printed subject index in Volume IV.« less

The safest parameters for FUS-induced blood-brain barrier opening without effects on the opening volume

NASA Astrophysics Data System (ADS)

Tung, Yao-Sheng; Olumolade, Yemi; Wang, Shutao; Wu, Shih-Ying; Konofagou, Elisa E.

2012-11-01

Acoustic cavitation has been identified as the main physical mechanism for the focused ultrasound (FUS) induced blood-brain barrier (BBB) opening. In this paper, the mechanism of stable cavitation (SC) and inertial cavitation (IC) responsible for BBB opening was investigated. Thirty-three (n=33) mice were intravenously injected with bubbles of 4-5 μm in diameter. The right hippocampus was then sonicated using focused 1.5-MHz ultrasound and three different studies were carried out. First, pulse lengths (PLs) of 0.1, 0.5, 2, and 5 ms at 0.18- MPa peak rarefactional pressure with 5-Hz pulse repetition frequency (PRF) and 5-minute duration were used to identify the threshold of PL using SC. Second, the effects of the duty cycle and exposure time were investigated. Third, the BBB opening size was compared between the SC and the IC. In the case of IC-induced BBB opening, a burst sequence (3-cycles PL; 5-Hz burst repetition frequency (BRF); 30 s duration) at 0.45 MPa was applied. Passive cavitation detection was performed with each sonication to detect whether a broadband response was obtained, i.e., if IC occurred, during BBB opening. The properties of BBB opening were measured through MRI. The threshold of PL for BBB opening was identified between 0.1 and 0.5 ms using SC, but the BBB can be opened in few cycles using IC. The BBB opening volume and normalized intensity increased with the PL, but reached saturation when the PL was above 2 ms. Once the PL threshold was reached, the same exposure time induced a similar BBB opening volume, but longer sonication duration induced higher MR intensity. The duty cycle was found not to play an important role on the BBB opening. Comparable BBB opening volume (20-25 mm3) could be reached between long PL (7500 cycles, i.e., 5 ms) at 0.18 MPa and 3 cycles at 0.45 MPa. 3-kDa fluorescently tagged dextran may be able to diffuse to the parenchyma after IC-induced BBB opening at 0.45 MPa but not after SC-induced BBB opening at 0.18 MPa.

[Psychological contract in the light of flexible employment: The review of studies].

PubMed

Żołnierczyk-Zreda, Dorota

Changing employment relations between employees and employers due to the increasing employment flexibility have contributed to the development of a new paradigm to analyze these relations based on the concept of psychological contract. This paradigm might be particularly relevant in Poland where the employment flexibility understood as the number of workers with temporary contracts is the highest in Europe. In this paper the concept of psychological contract is presented along with the existing findings related to its range, balance and contract fulfilment vs. contract breach. The results of studies showing the differences in psychological contract of temporary and permanent workers are also presented. The majority of them indicate that psychological contracts of temporary workers are limited in their extent, less balanced and asymmetric (to workers' disadvantage), as well as more transactional in their nature than those of permanent workers. The temporary workers' well-being and attitudes towards work and their reaction to psychological contract breach largely depends on their preferences for this type of employment, on their qualifications and on a labor market situation. Med Pr 2016;67(4):529-536. This work is available in Open Access model and licensed under a CC BY-NC 3.0 PL license.

The Weyl law for contractive maps

NASA Astrophysics Data System (ADS)

Spina, Maria E.; Rivas, Alejandro M. F.; Carlo, Gabriel

2013-11-01

We find an empirical Weyl law followed by the eigenvalues of contractive maps. An important property is that it is mainly insensitive to the dimension of the corresponding invariant classical set, the strange attractor. The usual explanation for the fractal Weyl law emergence in scattering systems (i.e., having a projective opening) is based on the classical phase space distributions evolved up to the quantum to classical correspondence (Ehrenfest) time. In the contractive case this reasoning fails to describe it. Instead, we conjecture that the support for this behavior is essentially given by the strong non-orthogonality of the eigenvectors of the contractive superoperator. We test the validity of the Weyl law and this conjecture on two paradigmatic systems, the dissipative baker and kicked top maps.

The petroleum explorationist's guide to contracts used in oil and gas operations

DOE Office of Scientific and Technical Information (OSTI.GOV)

Mosburg, L.G. Jr.

This volume provides articles and current sample forms of contract negotiation and drafting. The contents include: An introduction to oil and gas contracts; Effective deal negotiation; General principles of contract law and negotiation; Problems and pitfalls in support agreements; Sample support agreements; Basic concept of farmout agreements; Farmout negotiation checklist; ''Area of mutual interest'' provisions, Problems and pitfalls in 'contract (minimum) depth' and 'farmout (earned) depth' provisions; Options in interests assigned and reserved; Sample 'AMI' provision; ''conventional'' and ''revenue ruling 77-176'' farmout agreement forms; the AAPL model from operating agreement; 1982 revisions to the model form; Side-by-side comparisons of themore » 1956, 1977 and 1982 model forms, 1984 (1985) COPAS accounting procedure; Tax consequences of oil and gas exploration and development, revenue ruling 77-176; Use of tax partnerships and present assignments; Also materials on gas balancing agreements: Seismic options; and Structuring considerations.« less

Guidance, Navigation and Control Digital Emulation Technology Laboratory. Volume 1. Part 2. Task 1: Digital Emulation Technology Laboratory

DTIC Science & Technology

1991-09-27

AD-A241 692 II I] II I11 ANNUAL REPORT VOLUME 1 PART 2 TASK 1: DIGITAL EMULATION TECHNOLOGY LABORATOIRY REPORT NO. AR-0142-91-001 September 27, 1991... DIGITAL EMULATION TECHNOLOGY LABORATORY Contract No. DASG60-89-C-0142 Sponsored By The United States Army ? trategic Defense Command COMPUTER...ANNUAL REPORT VOLUME 1 PART 2 TASK 1: DIGITAL EMULATION TECHNOLOGY LABORATORY September 27, 1991 Authors Thomas R. Collins and Stephen R. Wachtel

17 CFR 190.03 - Operation of the debtor's estate subsequent to the primary liquidation date.

Code of Federal Regulations, 2010 CFR

2010-04-01

... contain open commodity contracts not required to be liquidated under § 190.02 (f)(1) shall be operated by the trustee as follows: (a) Operation of accounts held open for transfer—(1) Establishment of transfer accounts. On the primary liquidation date, the trustee must generate a new statement of account for each...

48 CFR 22.1014 - Delay over 60 days in bid opening or commencement of work.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 48 Federal Acquisition Regulations System 1 2010-10-01 2010-10-01 false Delay over 60 days in bid... ACQUISITION REGULATION SOCIOECONOMIC PROGRAMS APPLICATION OF LABOR LAWS TO GOVERNMENT ACQUISITIONS Service Contract Act of 1965, as Amended 22.1014 Delay over 60 days in bid opening or commencement of work. If a...

An Empirical Analysis of the Effectiveness of Design-Build Construction Contracts

DTIC Science & Technology

1993-08-01

features and benefits with traditional design/bid/build. Several types of design/build organizations are examined, with their relative advantages and... benefits transferable to government contracting? Perhaps the most logical approach would be to compare point by point the various advantages and...consider to be critical to their competitive advantage in the market. This paper opens with a review of the development of design/build, then contrasts its

Classical and adaptive control of ex vivo skeletal muscle contractions using Functional Electrical Stimulation (FES)

PubMed Central

Shoemaker, Adam; Grange, Robert W.; Abaid, Nicole; Leonessa, Alexander

2017-01-01

Functional Electrical Stimulation is a promising approach to treat patients by stimulating the peripheral nerves and their corresponding motor neurons using electrical current. This technique helps maintain muscle mass and promote blood flow in the absence of a functioning nervous system. The goal of this work is to control muscle contractions from FES via three different algorithms and assess the most appropriate controller providing effective stimulation of the muscle. An open-loop system and a closed-loop system with three types of model-free feedback controllers were assessed for tracking control of skeletal muscle contractions: a Proportional-Integral (PI) controller, a Model Reference Adaptive Control algorithm, and an Adaptive Augmented PI system. Furthermore, a mathematical model of a muscle-mass-spring system was implemented in simulation to test the open-loop case and closed-loop controllers. These simulations were carried out and then validated through experiments ex vivo. The experiments included muscle contractions following four distinct trajectories: a step, sine, ramp, and square wave. Overall, the closed-loop controllers followed the stimulation trajectories set for all the simulated and tested muscles. When comparing the experimental outcomes of each controller, we concluded that the Adaptive Augmented PI algorithm provided the best closed-loop performance for speed of convergence and disturbance rejection. PMID:28273101

ANALYSIS OF FLOW-STRUCTURE COUPLING IN A MECHANICAL MODEL OF THE VOCAL FOLDS AND THE SUBGLOTTAL SYSTEM.

PubMed

Howe, M S; McGowan, R S

2009-11-01

An analysis is made of the nonlinear interactions between flow in the subglottal vocal tract and glottis, sound waves in the subglottal system and a mechanical model of the vocal folds. The mean flow through the system is produced by a nominally steady contraction of the lungs, and mechanical experiments frequently involve a 'lung cavity' coupled to an experimental subglottal tube of arbitrary or ill-defined effective length L, on the basis that the actual value of L has little or no influence on excitation of the vocal folds. A simple, self-exciting single mass mathematical model of the vocal folds is used to investigate the sound generated within the subglottal domain and the unsteady volume flux from the glottis for experiments where it is required to suppress feedback of sound from the supraglottal vocal tract. In experiments where the assumed absorption of sound within the sponge-like interior of the lungs is small, the influence of changes in L can be very significant: when the subglottal tube behaves as an open-ended resonator (when L is as large as half the acoustic wavelength) there is predicted to be a mild increase in volume flux magnitude and a small change in waveform. However, the strong appearance of second harmonics of the acoustic field is predicted at intermediate lengths, when L is roughly one quarter of the acoustic wavelength. In cases of large lung damping, however, only modest changes in the volume flux are predicted to occur with variations in L.

POLLUTION EFFECTS OF ABNORMAL OPERATIONS IN IRON AND STEEL MAKING. VOLUME IV. OPEN HEARTH FURNACE, MANUAL OF PRACTICE

EPA Science Inventory

The report is one in a six-volume series considering abnormal operating conditions (AOCs) in the primary section (sintering, blast furnace ironmaking, open hearth, electric furnace, and basic oxygen steelmaking) of an integrated iron and steel plant. Pollution standards, generall...

Study of Manpower Requirements by Occupation for Alternative Technologies in the Energy-Related Industries, 1970-1990. Volumes I, IIA, and III.

ERIC Educational Resources Information Center

Gutmanis, Ivars; And Others

The report presents the methodology used by the National Planning Association (NPA), under contract to the Federal Energy Administration (FEA), to estimate direct labor usage coefficients in some sixty different occupational categories involved in construction, operation, and maintenance of energy facilities. Volume 1 presents direct labor usage…

Intrasystem Electromagnetic Compatibility Analysis Program. Volume 2. User’s Manual Usage Section

DTIC Science & Technology

1974-12-01

AD-A008 527 INTRASYSTEM ELECTROMAGNETIC COMPATI- BILITY ANALYSIS PROGRAM. VOLUME II.USER’S MANUAL USAGE SECTION J. L. Bogdanor , et al McDonnell...NUMBERVolume II - User’s Manual Usage Section None 7. AUTHOR(&) 8. CONTRACT OR GRANT NUMBER(s) J.L. Bogdanor F30602-72-C-0277 R.A. Pearlman M.D. Siegel

Department of Defense Acquisition of Vaccine Production. Volume 1

DTIC Science & Technology

2000-12-01

and by Science Applications International Corporation (SAIC) under a contract with the Office of the Director, Defense Research and Engineering...development clinical trials, manufacturing, and development; requires application of state-of- testing the-art research capability to problem solving...trials, vaccine recommending usage manufacturing scale, and logistics bodies (e.g., AFEB, ACIP) License application Prepare and submit -100 volume

Development of an Action Plan for the Creation of a Capacity Building Cell within the National Institute of Open Schooling, India. Contract No. C10A-159

ERIC Educational Resources Information Center

Mishra, Sanjaya

2010-01-01

In order to understand the Open Schooling system in India, the National Institute of Open Schooling (NIOS), and its operations, the author scanned and read a large number of documents in a short span of time. These readings formed the basis of his discussions with a range of stakeholders with whom he conducted interviews/interaction to gather…

Financial Management Regulation. Volume 15. Security Assistance Policy and Procedures

DTIC Science & Technology

1993-03-01

Definitions DEFINITIONS case level, i.e., commitments, obligations and 1. Above-the-line-Cost. Cost identified as disbursements resulting from contract award...of the asset or was a direct result of O ment is made when SAAC determines it does negligence, simple or gross. not have the accounting capability to... resulting from ments leaving the DoD system, contracts with operation of the FMS program: commercial firms, General Services Administra- tion

Multiyear Procurement (MYP) and Block Buy Contracting in Defense Acquisition: Background and Issues for Congress

DTIC Science & Technology

2017-03-16

principle reduce the cost of the weapons being procured in two primary ways:  Contractor optimization of workforce and production facilities. An...MYP contract gives the contractor (e.g., an airplane manufacturer or shipbuilder) confidence that a multiyear stream of business of a known volume...will very likely materialize. This confidence can permit the contractor to make investments in the firm’s workforce and production facilities that are

Validation of an algorithm for the nonrigid registration of longitudinal breast MR images using realistic phantoms

PubMed Central

Li, Xia; Dawant, Benoit M.; Welch, E. Brian; Chakravarthy, A. Bapsi; Xu, Lei; Mayer, Ingrid; Kelley, Mark; Meszoely, Ingrid; Means-Powell, Julie; Gore, John C.; Yankeelov, Thomas E.

2010-01-01

Purpose: The authors present a method to validate coregistration of breast magnetic resonance images obtained at multiple time points during the course of treatment. In performing sequential registration of breast images, the effects of patient repositioning, as well as possible changes in tumor shape and volume, must be considered. The authors accomplish this by extending the adaptive bases algorithm (ABA) to include a tumor-volume preserving constraint in the cost function. In this study, the authors evaluate this approach using a novel validation method that simulates not only the bulk deformation associated with breast MR images obtained at different time points, but also the reduction in tumor volume typically observed as a response to neoadjuvant chemotherapy. Methods: For each of the six patients, high-resolution 3D contrast enhanced T1-weighted images were obtained before treatment, after one cycle of chemotherapy and at the conclusion of chemotherapy. To evaluate the effects of decreasing tumor size during the course of therapy, simulations were run in which the tumor in the original images was contracted by 25%, 50%, 75%, and 95%, respectively. The contracted area was then filled using texture from local healthy appearing tissue. Next, to simulate the post-treatment data, the simulated (i.e., contracted tumor) images were coregistered to the experimentally measured post-treatment images using a surface registration. By comparing the deformations generated by the constrained and unconstrained version of ABA, the authors assessed the accuracy of the registration algorithms. The authors also applied the two algorithms on experimental data to study the tumor volume changes, the value of the constraint, and the smoothness of transformations. Results: For the six patient data sets, the average voxel shift error (mean±standard deviation) for the ABA with constraint was 0.45±0.37, 0.97±0.83, 1.43±0.96, and 1.80±1.17 mm for the 25%, 50%, 75%, and 95% contraction simulations, respectively. In comparison, the average voxel shift error for the unconstrained ABA was 0.46±0.29, 1.13±1.17, 2.40±2.04, and 3.53±2.89 mm, respectively. These voxel shift errors translate into compression of the tumor volume: The ABA with constraint returned volumetric errors of 2.70±4.08%, 7.31±4.52%, 9.28±5.55%, and 13.19±6.73% for the 25%, 50%, 75%, and 95% contraction simulations, respectively, whereas the unconstrained ABA returned volumetric errors of 4.00±4.46%, 9.93±4.83%, 19.78±5.657%, and 29.75±15.18%. The ABA with constraint yields a smaller mean shift error, as well as a smaller volume error (p=0.031 25 for the 75% and 95% contractions), than the unconstrained ABA for the simulated sets. Visual and quantitative assessments on experimental data also indicate a good performance of the proposed algorithm. Conclusions: The ABA with constraint can successfully register breast MR images acquired at different time points with reasonable error. To the best of the authors’ knowledge, this is the first report of an attempt to quantitatively assess in both phantoms and a set of patients the accuracy of a registration algorithm for this purpose. PMID:20632566

MM T for linear resonant cooler. Volume 1. Final report, October 1984-September 1986

DOE Office of Scientific and Technical Information (OSTI.GOV)

Narayan, R.; Silvestro, J.

1988-02-16

The three-fold objectives of this contract were to: (1) enhance the producibility and performance of the prototype cooler design developed in a prior contract, (b) qualify the design to the target specification in the contract (basically the HD1045/UA B2 specification amended for 2,500 hour MTTF and low audible noise), and (c) develop and demonstrate a pilot production facility for the cooler. Technical difficulties and cost growth related to objectives (a) and (b) above precluded accomplishing (c) as part of this contract's activities. Nevertheless, performance within or exceeding all major requirements has been demonstrated, and the company is currently producing themore » cooler for use on a U.S. Air Force airborne IR system.« less

A proposed application programming interface for a physical volume repository

NASA Technical Reports Server (NTRS)

Jones, Merritt; Williams, Joel; Wrenn, Richard

1996-01-01

The IEEE Storage System Standards Working Group (SSSWG) has developed the Reference Model for Open Storage Systems Interconnection, Mass Storage System Reference Model Version 5. This document, provides the framework for a series of standards for application and user interfaces to open storage systems. More recently, the SSSWG has been developing Application Programming Interfaces (APIs) for the individual components defined by the model. The API for the Physical Volume Repository is the most fully developed, but work is being done on APIs for the Physical Volume Library and for the Mover also. The SSSWG meets every other month, and meetings are open to all interested parties. The Physical Volume Repository (PVR) is responsible for managing the storage of removable media cartridges and for mounting and dismounting these cartridges onto drives. This document describes a model which defines a Physical Volume Repository, and gives a brief summary of the Application Programming Interface (API) which the IEEE Storage Systems Standards Working Group (SSSWG) is proposing as the standard interface for the PVR.

48 CFR 237.7400 - Scope.

Code of Federal Regulations, 2012 CFR

2012-10-01

....7400 Scope. This subpart prescribes procedures for contracting, through use of other than full and open competition, with local governments for police, fire protection, airfield operation, or other community...

48 CFR 237.7400 - Scope.

Code of Federal Regulations, 2010 CFR

2010-10-01

....7400 Scope. This subpart prescribes procedures for contracting, through use of other than full and open competition, with local governments for police, fire protection, airfield operation, or other community...

48 CFR 237.7400 - Scope.

Code of Federal Regulations, 2013 CFR

2013-10-01

....7400 Scope. This subpart prescribes procedures for contracting, through use of other than full and open competition, with local governments for police, fire protection, airfield operation, or other community...

48 CFR 237.7400 - Scope.

Code of Federal Regulations, 2014 CFR

2014-10-01

....7400 Scope. This subpart prescribes procedures for contracting, through use of other than full and open competition, with local governments for police, fire protection, airfield operation, or other community...

48 CFR 237.7400 - Scope.

Code of Federal Regulations, 2011 CFR

2011-10-01

....7400 Scope. This subpart prescribes procedures for contracting, through use of other than full and open competition, with local governments for police, fire protection, airfield operation, or other community...

The effectiveness of contracting-out primary health care services in developing countries: a review of the evidence.

PubMed

Liu, Xingzhu; Hotchkiss, David R; Bose, Sujata

2008-01-01

The purpose of this study is to review the research literature on the effectiveness of contracting-out of primary health care services and its impact on both programme and health systems performance in low- and middle-income countries. Due to the heightened interest in improving accountability relationships in the health sector and in rapidly scaling up priority interventions, there is an increasing amount of interest in and experimentation with contracting-out. Overall, while the review of the selected studies suggests that contracting-out has in many cases improved access to services, the effects on other performance dimensions such as equity, quality and efficiency are often unknown. Moreover, little is known about the system-wide effects of contracting-out, which could be either positive or negative. Although the study results leave open the question of how contracting-out can be used as a policy tool to improve overall health system performance, the results indicate that the context in which contracting-out is implemented and the design features of the interventions are likely to greatly influence the chances for success.

Influence of cutaneous and muscular circulation on spatially resolved versus standard Beer-Lambert near-infrared spectroscopy.

PubMed

Messere, Alessandro; Roatta, Silvestro

2013-12-01

The potential interference of cutaneous circulation on muscle blood volume and oxygenation monitoring by near-infrared spectroscopy (NIRS) remains an important limitation of this technique. Spatially resolved spectroscopy (SRS) was reported to minimize the contribution of superficial tissue layers in cerebral monitoring but this characteristic has never been documented in muscle tissue monitoring. This study aims to compare SRS with the standard Beer-Lambert (BL) technique in detecting blood volume changes selectively induced in muscle and skin. In 16 healthy subjects, the biceps brachii was investigated during isometric elbow flexion at 70% of the maximum voluntary contractions lasting 10 sec, performed before and after exposure of the upper arm to warm air flow. From probes applied over the muscle belly the following variables were recorded: total hemoglobin index (THI, SRS-based), total hemoglobin concentration (tHb, BL-based), tissue oxygenation index (TOI, SRS-based), and skin blood flow (SBF), using laser Doppler flowmetry. Blood volume indices exhibited similar changes during muscle contraction but only tHb significantly increased during warming (+5.2 ± 0.7 μmol/L·cm, an effect comparable to the increase occurring in postcontraction hyperemia), accompanying a 10-fold increase in SBF. Contraction-induced changes in tHb and THI were not substantially affected by warming, although the tHb tracing was shifted upward by (5.2 ± 3.5 μmol/L·cm, P < 0.01). TOI was not affected by cutaneous warming. In conclusion, SRS appears to effectively reject interference by SBF in both muscle blood volume and oxygenation monitoring. Instead, BL-based parameters should be interpreted with caution, whenever changes in cutaneous perfusion cannot be excluded.

Receptors mediating the effects of substance P and neurokinin A on mucus secretion and smooth muscle tone of the ferret trachea: potentiation by an enkephalinase inhibitor.

PubMed Central

Webber, S. E.

1989-01-01

1. The effects of substance P (SP) and neurokinin A (NKA) were examined on tracheal smooth muscle tone, mucus volume output, lysozyme output and albumin transport across the ferret in vitro whole trachea in the presence and absence of the enkephalinase inhibitor, thiorphan. 2. SP (0.001-3 microM) and NKA (0.01-10 microM) contracted the tracheal smooth muscle and increased mucus volume, lysozyme and albumin outputs into the tracheal lumen. The EC50 values for SP and NKA for all of the variables measured were significantly reduced, and all of the maximum responses were significantly enhanced by thiorphan (10 microM). 3. In the presence of thiorphan, SP (1 microM) and NKA (10 microM) produced albumin concentrations in the secreted mucus (8.9 and 7.2 micrograms microliters-1) which were greater than those in the submucosal buffer (4.2 micrograms microliters-1). 4. In the presence of thiorphan, NKA was approximately 5 times more potent than SP at contracting the tracheal smooth muscle. Conversely SP was 23, 15 and 22 times more potent than NKA at stimulating mucus volume, lysozyme and albumin outputs respectively. 5. Thus, there is neutral endopeptidase in the ferret trachea in vitro which cleaves exogenously applied SP and NKA, thereby reducing the magnitude and potency of their actions. SP and NKA contract the ferret tracheal muscle probably by an action at NK2 (or NK3)-receptors but stimulate mucus volume output, lysozyme output and albumin transport across the tracheal wall probably by an action on NK1 receptors. PMID:2482101

Receptors mediating the effects of substance P and neurokinin A on mucus secretion and smooth muscle tone of the ferret trachea: potentiation by an enkephalinase inhibitor.

PubMed

Webber, S E

1989-12-01

1. The effects of substance P (SP) and neurokinin A (NKA) were examined on tracheal smooth muscle tone, mucus volume output, lysozyme output and albumin transport across the ferret in vitro whole trachea in the presence and absence of the enkephalinase inhibitor, thiorphan. 2. SP (0.001-3 microM) and NKA (0.01-10 microM) contracted the tracheal smooth muscle and increased mucus volume, lysozyme and albumin outputs into the tracheal lumen. The EC50 values for SP and NKA for all of the variables measured were significantly reduced, and all of the maximum responses were significantly enhanced by thiorphan (10 microM). 3. In the presence of thiorphan, SP (1 microM) and NKA (10 microM) produced albumin concentrations in the secreted mucus (8.9 and 7.2 micrograms microliters-1) which were greater than those in the submucosal buffer (4.2 micrograms microliters-1). 4. In the presence of thiorphan, NKA was approximately 5 times more potent than SP at contracting the tracheal smooth muscle. Conversely SP was 23, 15 and 22 times more potent than NKA at stimulating mucus volume, lysozyme and albumin outputs respectively. 5. Thus, there is neutral endopeptidase in the ferret trachea in vitro which cleaves exogenously applied SP and NKA, thereby reducing the magnitude and potency of their actions. SP and NKA contract the ferret tracheal muscle probably by an action at NK2 (or NK3)-receptors but stimulate mucus volume output, lysozyme output and albumin transport across the tracheal wall probably by an action on NK1 receptors.

Developing Open-Ended Questions for Surface Area and Volume of Beam

ERIC Educational Resources Information Center

Kurniawan, Henry; Putri, Ratu Ilma Indra; Hartono, Yusuf

2018-01-01

The purpose of this research was to show open-ended questions about surface area and beam volume which valid and practice, have potential effect. This research is research development which consists of two main phases: preliminary phase (preparation phase and problem design) and formative evaluation phase (evaluation and revision phases). The…

Scientific Journal Publishing: Yearly Volume and Open Access Availability

ERIC Educational Resources Information Center

Bjork, Bo-Christer; Roos, Annikki; Lauri, Mari

2009-01-01

Introduction: We estimate the total yearly volume of peer-reviewed scientific journal articles published world-wide as well as the share of these articles available openly on the Web either directly or as copies in e-print repositories. Method: We rely on data from two commercial databases (ISI and Ulrich's Periodicals Directory) supplemented by…

Cardiac cycle-dependent left atrial dynamics: implications for catheter ablation of atrial fibrillation.

PubMed

Patel, Amit R; Fatemi, Omid; Norton, Patrick T; West, J Jason; Helms, Adam S; Kramer, Christopher M; Ferguson, John D

2008-06-01

Left atrial (LA) volume determines prognosis and response to therapy for atrial fibrillation. Integration of electroanatomic maps with three-dimensional images rendered from computed tomography and magnetic resonance imaging (MRI) is used to facilitate atrial fibrillation ablation. The purpose of this study was to measure LA volume changes and regional motion during the cardiac cycle that might affect the accuracy of image integration and to determine their relationship to standard LA volume measurements. MRI was performed in 30 patients with paroxysmal atrial fibrillation. LA time-volume curves were generated and used to divide LA ejection fraction into pumping ejection fraction and conduit ejection fraction and to determine maximum LA volume (LA(max)) and preatrial contraction volume. LA volume was measured using an MRI angiogram and traditional geometric models from echocardiography (area-length model and ellipsoid model). In-plane displacement of the pulmonary veins, anterior left atrium, mitral annulus, and LA appendage was measured. LA(max) was 107 +/- 36 mL and occurred at 42% +/- 5% of the R-R interval. Preatrial contraction volume was 86 +/- 34 mL and occurred at 81% +/- 4% of the R-R interval. LA ejection fraction was 45% +/- 10%, and pumping ejection fraction was 31% +/- 10%. LA volume measurements made from MRI angiogram, area-length model, and ellipsoid model underestimated LA(max) by 21 +/- 25 mL, 16 +/- 26 mL, and 35 +/- 22 mL, respectively. Anterior LA, mitral annulus, and LA appendage were significantly displaced during the cardiac cycle (8.8 +/- 2.0 mm, 13.2 +/- 3.8 mm, and 10.2 +/- 3.4 mm, respectively); the pulmonary veins were not displaced. LA volume changes significantly during the cardiac cycle, and substantial regional variation in LA motion exists. Standard measurements of LA volume significantly underestimate LA(max) compared to the gold standard measure of three-dimensional volumetrics.

The Effects of Hydrotherapy on Anxiety, Pain, Neuroendocrine Responses, and Contraction Dynamics During Labor

PubMed Central

Benfield, Rebecca D.; Hortobágyi, Tibor; Tanner, Charles J.; Swanson, Melvin; Heitkemper, Margaret M.; Newton, Edward R.

2013-01-01

Background Hydrotherapy (immersion, or bathing) is used worldwide to promote relaxation and decrease parturient anxiety and pain in labor, but the psychophysiological effects of this intervention remain obscure. Design A pre-test post-test design with repeated measures was used to examine the effects of hydrotherapy on maternal anxiety and pain, neuroendocrine responses, plasma volume shift and uterine contractions during labor. Correlations among variables were examined at three time points (pre-immersion and twice during hydrotherapy). Methods Eleven term women (mean age 24.5 years) in spontaneous labor were immersed to the xiphoid in 37°C water for 1 hr. Blood samples and measures of anxiety and pain were obtained under dry baseline conditions and repeated at 15 and 45 min of hydrotherapy. Uterine contractions were monitored telemetrically. Results Hydrotherapy was associated with decreases in anxiety, vasopressin and oxytocin levels at 15 and 45 min (all p < .05). There were no significant differences between pre-immersion and immersion pain or cortisol levels. Pain decreased more for women with high baseline pain than for women with low baseline levels at 15 and 45 min. Cortisol levels decreased twice as much at 15 min of hydrotherapy for women with high baseline pain as for those with low baseline pain. Beta-endorphin levels increased at 15 min but did not differ between baseline and 45 min. During immersion, uterine-contraction frequency decreased. A positive plasma volume shift at 15 min was correlated with contraction duration. Conclusions Hydrotherapy during labor affects neuroendocrine responses that modify psychophysiological processes. PMID:20453024

Cell-populated collagen lattice contraction model for the investigation of fibroblast collagen interactions.

PubMed

Ehrlich, H Paul; Moyer, Kurtis E

2013-01-01

The fibroblast-populated collagen lattice (FPCL) was intended to act as the dermal component for "skin-equivalent" or artificial skin developed for skin grafting burn patients. The "skin-equivalent" was clinically unsuccessful as a skin graft, but today it is successfully used as a dressing for the management of chronic wounds. The FPCL has, however, become an instrument for investigating cell-connective tissue interactions within a three-dimensional matrix. Through the capacity of cell compaction of collagen fibrils, the FPCL undergoes a reduction in volume referred to as lattice contraction. Lattice contraction proceeds by cell-generated forces that reduce the water mass between collagen fibers, generating a closer relationship between collagen fibers. The compaction of collagen fibers is responsible for the reduction in the FPCL volume. Cell-generated forces through the linkage of collagen fibers with fibroblast's cytoskeletal actin-rich microfilament structures are responsible for the completion of the collagen matrix compaction. The type of culture dish used to cast FPCL as well as the cell number will dictate the mechanism for compacting collagen matrices. Fibroblasts, at moderate density, cast as an FPCL within a petri dish and released from the surface of the dish soon after casting compact collagen fibers through cell tractional forces. Fibroblasts at moderate density cast as an FPCL within a tissue culture dish and not released for 4 days upon release show rapid lattice contraction through a mechanism of cell contraction forces. Fibroblasts at high density cast in an FPCL within a petri dish, released from the surface of the dish soon after casting, compact a collagen lattice very rapidly through forces related to cell elongation. The advantage of the FPCL contraction model is the study of cells in the three-dimensional environment, which is similar to the environment from which these cells were isolated. In this chapter methods are described for manufacturing collagen lattices, which assess the three forces involved in compacting and/or organizing collagen fibrils into thicker collagen fibers. The clinical relevance of the FPCL contraction model is related to advancing our understanding of wound contraction and scar contracture.

Tenure, Civil Rights Laws, Inclusive Contracts, and Fear: Legal Protection and the Lives of Self-Identified Lesbian, Gay Male, and Bisexual Public School Teachers.

ERIC Educational Resources Information Center

Juul, Thomas Patrick

This paper presents findings of a study that examined the results of tenure and legal protection on lesbian, gay male, and bisexual public school teachers. Specifically, it describes the effect of tenure, state laws, inclusive contracts, and local ordinances on the openness and public identities of gay teachers. A total of 904 out of 1,400…

Antidotes for Ricin Intoxication. Effects of Ricin on the Vascular Neuroeffector System

DTIC Science & Technology

1992-10-25

advent of monoclonal antibodies opened up a whole new world of possibilities for the therapeutic use of ricin. By targeting the toxin to a specific...AD-A261 950 CONTRACT NO: DAMD17-90-C-0109 S TITLE: ANTIDOTES FOR RICIN INTOXICATION SUBTITLE: Effects of Ricin on the Vascular Neuroeffector System...PRINCIPAL INVESTIGATOR: Casey Robinson AUTIORS: Victoria J. Christiansen, Chia-Hsuh Hsu, Lin Zhang CONTRACTING ORGANIZATION: University of Oklahoma

Standard Port-Visit Cost Forecasting Model for U.S. Navy Husbanding Contracts

DTIC Science & Technology

2009-12-01

Protocol (HTTP) server.35 2. MySQL . An open-source database.36 3. PHP . A common scripting language used for Web development.37 E. IMPLEMENTATION OF...Inc. (2009). MySQL Community Server (Version 5.1) [Software]. Available from http://dev.mysql.com/downloads/ 37 The PHP Group (2009). PHP (Version...Logistics Services MySQL My Structured Query Language NAVSUP Navy Supply Systems Command NC Non-Contract Items NPS Naval Postgraduate

30 CFR 291.103 - May I use alternative dispute resolution to informally resolve an allegation that open and...

Code of Federal Regulations, 2011 CFR

2011-07-01

... that open and nondiscriminatory access was denied? You may ask to use ADR either before or after you..., NW., Mail Stop 5438, Washington, DC 20240-0001. (a) You may request that ADR be administered by: (1) A contracted ADR provider agreed to by all parties; (2) The Department's Office of Collaborative...

48 CFR 6.302-1 - Only one responsible source and no other supplies or services will satisfy agency requirements.

Code of Federal Regulations, 2011 CFR

2011-10-01

... REQUIREMENTS Other Than Full and Open Competition 6.302-1 Only one responsible source and no other supplies or... sources, and no other type of supplies or services will satisfy agency requirements, full and open... from the original source in the case of a follow-on contract for the continued development or...

Thermodynamic evaluation of transonic compressor rotors using the finite volume approach

NASA Technical Reports Server (NTRS)

Moore, John; Nicholson, Stephen; Moore, Joan G.

1986-01-01

The development of a computational capability to handle viscous flow with an explicit time-marching method based on the finite volume approach is summarized. Emphasis is placed on the extensions to the computational procedure which allow the handling of shock induced separation and large regions of strong backflow. Appendices contain abstracts of papers and whole reports generated during the contract period.

Physiological Responses to Acute Exercise-Heat Stress

DTIC Science & Technology

1988-01-01

muscle contraction and to dissipate the associated heat release. In hot environments, the core to skin temperature gradient is reduced to skin blood flow needs to be relatively high (compared to cooler environments) to achieve heat transfer sufficient for thermal balance. In addition, sweat secretion can result in a reduced plasma (by dehydration) and thus blood volume. Both high skin blood flow and reduced plasma volume can reduce

Adjustment of Host Cells for Accommodation of Symbiotic Bacteria: Vacuole Defunctionalization, HOPS Suppression, and TIP1g Retargeting in Medicago[C][W][OPEN

PubMed Central

Gavrin, Aleksandr; Kaiser, Brent N.; Geiger, Dietmar; Tyerman, Stephen D.; Wen, Zhengyu; Bisseling, Ton; Fedorova, Elena E.

2014-01-01

In legume–rhizobia symbioses, the bacteria in infected cells are enclosed in a plant membrane, forming organelle-like compartments called symbiosomes. Symbiosomes remain as individual units and avoid fusion with lytic vacuoles of host cells. We observed changes in the vacuole volume of infected cells and thus hypothesized that microsymbionts may cause modifications in vacuole formation or function. To examine this, we quantified the volumes and surface areas of plant cells, vacuoles, and symbiosomes in root nodules of Medicago truncatula and analyzed the expression and localization of VPS11 and VPS39, members of the HOPS vacuole-tethering complex. During the maturation of symbiosomes to become N2-fixing organelles, a developmental switch occurs and changes in vacuole features are induced. For example, we found that expression of VPS11 and VPS39 in infected cells is suppressed and host cell vacuoles contract, permitting the expansion of symbiosomes. Trafficking of tonoplast-targeted proteins in infected symbiotic cells is also altered, as shown by retargeting of the aquaporin TIP1g from the tonoplast membrane to the symbiosome membrane. This retargeting appears to be essential for the maturation of symbiosomes. We propose that these alterations in the function of the vacuole are key events in the adaptation of the plant cell to host intracellular symbiotic bacteria. PMID:25217511

NASA's Space Launch System Advanced Booster Development

NASA Technical Reports Server (NTRS)

Robinson, Kimberly F.; Crumbly, Christopher M.; May, Todd A.

2014-01-01

The National Aeronautics and Space Administration's (NASA's) Space Launch System (SLS) Program, managed at the Marshall Space Flight Center, is making progress toward delivering a new capability for human space flight and scientific missions beyond Earth orbit. NASA is executing this development within flat budgetary guidelines by using existing engines assets and heritage technology to ready an initial 70 metric ton (t) lift capability for launch in 2017, and then employing a block upgrade approach to evolve a 130-t capability after 2021. A key component of the SLS acquisition plan is a three-phased approach for the first-stage boosters. The first phase is to expedite the 70-t configuration by completing development of the Space Shuttle heritage 5-segment solid rocket boosters (SRBs) for the initial flights of SLS. Since no existing boosters can meet the performance requirements for the 130-t class SLS, the next phases of the strategy focus on the eventual development of advanced boosters with an expected thrust class potentially double the current 5-segment solid rocket booster capability of 3.88 million pounds of thrust each. The second phase in the booster acquisition plan is the Advanced Booster Engineering Demonstration and/or Risk Reduction (ABEDRR) effort, for which contracts were awarded beginning in 2012 after a full and open competition, with a stated intent to reduce risks leading to an affordable advanced booster. NASA has awarded ABEDRR contracts to four industry teams, which are looking into new options for liquid-fuel booster engines, solid-fuel-motor propellants, and composite booster structures. Demonstrations and/or risk reduction efforts were required to be related to a proposed booster concept directly applicable to fielding an advanced booster. This paper will discuss the status of this acquisition strategy and its results toward readying both the 70 t and 130 t configurations of SLS. The third and final phase will be a full and open competition for Design, Development, Test, and Evaluation (DDT&E) of the advanced boosters. These new boosters will enable the flexible path approach to deep space exploration, opening up vast opportunities for human missions to near-Earth asteroids and Mars. This evolved capability will offer large volume for science missions and payloads, will be modular and flexible, and will be right-sized for mission requirements.

Common Ada Missile Packages. Phase 2. (CAMP-2). Volume 2. 11th Missile Demonstration

DTIC Science & Technology

1988-11-01

report describes the work performed, Ihe results obtained, and the conclusions reached during the Common Ada Missile Packages Phase-2 (CAMP-2) contract ... contract was performed between Sep- tember 1985. and March 1988. The MDAC-STL CAMP program manager was: Dr. Daniel G. McNicholl Technology Branch...j DEC Code Management System X X Software Development Files x x Development Status Database x ! X i Smart Cade Counter X j

Housing Operations Management System (HOMES). Volume 1. Executive Summary

DTIC Science & Technology

1984-08-01

output products become available. One of these products is the Reimburs - able Order and Contract Ledger. By entering a Reimbursable Order (RO) Number or...Development Products Menu 108 G8 HOMES Budget Execution Menu 109 G9 Budget Execution Flow 110 G1O Commitments and Obligations Ledger il1 Gil Reimbursable ...are in a specified percentage range liquidated. Figure ClI shows the format of the Reimbursable Order and Contract Ledger. Figure 012 shows the

Defense AT and L Magazine. Volume 45, Number 2, March-April 2016

DTIC Science & Technology

2016-03-01

preferred contract type (Fixed Price Incentive Firm and Cost Plus Incentive Fee may be effective) 5. Provide sufficient contract length for the...example would be an incentive on pay- load margin for our medium launch vehicle, where the mini - mum requirement is 100 pounds of margin and the...involving a mini -UAV initiative with Indian industry partners. In discussing the Make in India initiative, U.S. officials note that it requires time

Structural study of some divalent aluminoborate glasses using ultrasonic and positron annihilation techniques

NASA Astrophysics Data System (ADS)

Saddeek, Yasser B.; Mohamed, Hamdy F. M.; Azooz, Moenis A.

2004-07-01

Positron annihilation lifetime (PAL), ultrasonic techniques, and differential thermal analysis (DTA) were performed to study the structure of some aluminoborate glasses. The basic compositions of these glasses are 50 B2O3 + 10 Al2O3 + 40 RO (wt%), where RO is the divalent oxide (MgO, CaO, SrO, and CdO). The ultrasonic data show that the rigidity increases from MgO to CaO then decrease at SrO and again increases at CdO. The glass transition temperature (determined from DTA) decreases from MgO to SrO then increases at CdO. The trend of the thermal properties was attributed to thermal stability. The experimental data are correlated with the internal glass structure and its connectivity. The PAL data show that an inversely correlation between the relative fractional of the open hole volume and the density of the samples. Also, there is a good correlation between the ortho-positronium (o-Ps) lifetime (open hole volume size) and the bulk modulus of the samples (determined from ultrasonic technique). The open volume hole size distribution for the samples shows that the open volume holes expand in size for CaO, SrO, MgO, and CdO, respectively with their distribution function moving to higher volume size.

Microbubble gas volume: A unifying dose parameter in blood-brain barrier opening by focused ultrasound.

PubMed

Song, Kang-Ho; Fan, Alexander C; Hinkle, Joshua J; Newman, Joshua; Borden, Mark A; Harvey, Brandon K

2017-01-01

Focused ultrasound with microbubbles is being developed to transiently, locally and noninvasively open the blood-brain barrier (BBB) for improved pharmaceutical delivery. Prior work has demonstrated that, for a given concentration dose, microbubble size affects both the intravascular circulation persistence and extent of BBB opening. When matched to gas volume dose, however, the circulation half-life was found to be independent of microbubble size. In order to determine whether this holds true for BBB opening as well, we independently measured the effects of microbubble size (2 vs. 6 µm diameter) and concentration, covering a range of overlapping gas volume doses (1-40 µL/kg). We first demonstrated precise targeting and a linear dose-response of Evans Blue dye extravasation to the rat striatum for a set of constant microbubble and ultrasound parameters. We found that dye extravasation increased linearly with gas volume dose, with data points from both microbubble sizes collapsing to a single line. A linear trend was observed for both the initial sonication (R 2 =0.90) and a second sonication on the contralateral side (R 2 =0.68). Based on these results, we conclude that microbubble gas volume dose, not size, determines the extent of BBB opening by focused ultrasound (1 MHz, ~0.5 MPa at the focus). This result may simplify planning for focused ultrasound treatments by constraining the protocol to a single microbubble parameter - gas volume dose - which gives equivalent results for varying size distributions. Finally, using optimal parameters determined for Evan Blue, we demonstrated gene delivery and expression using a viral vector, dsAAV1-CMV-EGFP, one week after BBB disruption, which allowed us to qualitatively evaluate neuronal health.

Developing Performance Based Requirements for Open Architecture Design

DTIC Science & Technology

2006-04-30

Åèìáëáíáçå= oÉëÉ~êÅÜ=póãéçëáìã= DEVELOPING PERFORMANCE BASED REQUIREMENTS FOR OPEN ARCHITECTURE DESIGN Published: 30 April 2006 by Brad Naegle...for Open Architecture Design 5a. CONTRACT NUMBER 5b. GRANT NUMBER 5c. PROGRAM ELEMENT NUMBER 6. AUTHOR(S) 5d. PROJECT NUMBER 5e. TASK NUMBER 5f...Ñçê=áåÑçêãÉÇ=ÅÜ~åÖÉ======= = - 174 - = = Developing Performance Based Requirements for Open Architecture Design Presenter: Brad Naegle, Lieutenant

Scientific Integrity and Executive National Security Proclamations: A Conflict of the Modern Age

NASA Astrophysics Data System (ADS)

Nelson, R.; Banerdt, B.; Bell, J. L.; Byrnes, D. V.; Carlisle, G. L.; D'Addario, L. R.; Weissman, P. R.; Eisenhardt, P. R.; Foster, S. D.; Golombek, M. P.; Gorjian, V.; Gorjian, Z.; Hale, A. S.; Kulleck, J. G.; Laubach, S. L.; McElrath, T. P.; Penanen, K. I.; Satter, C.; Walker, W. J.

2010-12-01

In 2004, in response to the events of September, 11, 2001, President George W. Bush issued Homeland Security Presidential Directive #12, an executive order requiring a uniform means of identification (i.e. identification badge) for all employees and contractors at federal facilities. To comply with this directive NASA ordered that its contract employees at the Jet Propulsion Laboratory 'voluntarily' agree to an open ended, unrestricted, background investigation into the intimate details of their private lives. These employees do not have security clearances and do not work with classified material. Caltech, which employs the JPL personnel under a NASA management contract, informed the employees that if they did not ‘voluntarily’ consent to the background investigation, they would be assumed to have voluntarily resigned and therefore be denied access to JPL (i.e. they would be functionally terminated). In October 2007, twentyeight JPL employees filed suit in Federal District Court. After an initial dismissal by the lowest federal court, the Ninth Circuit Court of Appeals issued an injunction against Caltech and NASA, stopping the background investigations. The Appeals Court found that the investigations were not narrowly tailored to meet the specific needs of NASA and therefore violated the employee’s legitimate expectation of informational privacy. This injunction has been reviewed and upheld several times by various panels of the Ninth Circuit Court of Appeals. In November 2009, the United States Department of Justice petitioned the U.S. Supreme Court requesting that it overturn this injunction. The Supreme Court accepted the case for oral arguments and scheduled them for October 5, 2010. A decision is imminent (if it has not been made already). The case has opened the following questions regarding all research workers under government contract: 1. What impact would such intrusive investigations have on open scientific inquiry and scientific integrity? 2. How much can the Government reasonably ask about the backgrounds of its contract employees? 3. What rights do employees have to challenge the findings of their background investigations, and can the results of such investigations be contested in the courts? 4. What is the responsibility of a contract employer such as Caltech to protect the privacy of contract research workers like those at JPL? 5. What is the responsibility of professional societies in representing the interests of federal contract employees such as those at JPL? 6. What would constitute a reasonable background investigation of contract employees that would be narrowly tailored in order to protect informational privacy? This work is a private venture. Affiliations are listed for identification purposes only. No NASA, Caltech or JPL resources were expended in producing this abstract.

Intra-gastric triacetin alters upper gastrointestinal motility in conscious dogs.

PubMed

Oosaka, Kazumasa; Tokuda, Masaaki; Furukawa, Naohiro

2014-01-28

To examine the effect of intra-gastric triacetin on both upper gastrointestinal motility and proximal gastric tone in conscious dogs. Three beagle dogs under sedation were surgically implanted with gastrocutaneous fistula in the gastric body and force transducers in the gastric antrum and duodenum. Beginning at week-2 after insertion, the animals were either fasted for 24 h or fed a liquid meal 2-3 h before the experiment. With the animals fully conscious, a polyethylene bag was inserted into the proximal stomach through the gastrocutaneous fistula, followed by 15 min of air inflation (minimal distending pressure of ＋2 mmHg) and then 20 mL of a low-, mid- or high-concentration triacetin solution (0.5%, 1.0% and 2.0%) or warm water (vehicle control). The proximal stomach receptive volume and gastric antral and duodenal contractions were measured over 10 min. The experiment was repeated twice per week over several months, with each animal receiving at least one infusion of the various triacetin solutions and the vehicle at different times. Intergroup differences were assessed by ANOVA and Bonferroni-Dunn post-hoc testing. Intra-gastric infusion of mid- and high-concentration triacetin induced an increase in the proximal stomach receptive volume, and the average increase induced by the high-concentration at 0-4 min after infusion was significantly greater than that induced by the vehicle control (62.4 ± 9.8 vs 18.4 ± 4.7, P < 0.01). The mid- and high-concentration triacetin also produced a temporary inhibition of the gastric antral contractions at 2 min after infusions; however, only the fasted group showed triacetin-induced antral contractile inhibition that was significantly greater than that in the vehicle control group (P < 0.05). In addition, only the fasted group showed a high-concentration triacetin-induced increase in duodenal contractions at 9-10 min that was significantly different from that in the vehicle control group (P < 0.05). Intra-gastric infusion of 1.0%-2.0% triacetin delays gastric emptying by increasing proximal stomach receptive volume, temporarily inhibiting gastric antral contractions and facilitating duodenal contractions.

Intra-gastric triacetin alters upper gastrointestinal motility in conscious dogs

PubMed Central

Oosaka, Kazumasa; Tokuda, Masaaki; Furukawa, Naohiro

2014-01-01

AIM: To examine the effect of intra-gastric triacetin on both upper gastrointestinal motility and proximal gastric tone in conscious dogs. METHODS: Three beagle dogs under sedation were surgically implanted with gastrocutaneous fistula in the gastric body and force transducers in the gastric antrum and duodenum. Beginning at week-2 after insertion, the animals were either fasted for 24 h or fed a liquid meal 2-3 h before the experiment. With the animals fully conscious, a polyethylene bag was inserted into the proximal stomach through the gastrocutaneous fistula, followed by 15 min of air inflation (minimal distending pressure of ＋2 mmHg) and then 20 mL of a low-, mid- or high-concentration triacetin solution (0.5%, 1.0% and 2.0%) or warm water (vehicle control). The proximal stomach receptive volume and gastric antral and duodenal contractions were measured over 10 min. The experiment was repeated twice per week over several months, with each animal receiving at least one infusion of the various triacetin solutions and the vehicle at different times. Intergroup differences were assessed by ANOVA and Bonferroni-Dunn post-hoc testing. RESULTS: Intra-gastric infusion of mid- and high-concentration triacetin induced an increase in the proximal stomach receptive volume, and the average increase induced by the high-concentration at 0-4 min after infusion was significantly greater than that induced by the vehicle control (62.4 ± 9.8 vs 18.4 ± 4.7, P < 0.01). The mid- and high-concentration triacetin also produced a temporary inhibition of the gastric antral contractions at 2 min after infusions; however, only the fasted group showed triacetin-induced antral contractile inhibition that was significantly greater than that in the vehicle control group (P < 0.05). In addition, only the fasted group showed a high-concentration triacetin-induced increase in duodenal contractions at 9-10 min that was significantly different from that in the vehicle control group (P < 0.05). CONCLUSION: Intra-gastric infusion of 1.0%-2.0% triacetin delays gastric emptying by increasing proximal stomach receptive volume, temporarily inhibiting gastric antral contractions and facilitating duodenal contractions. PMID:24574778

Investigation of the effects of P2 purinoceptor ligands on the micturition reflex in female urethane-anaesthetized rats.

PubMed

King, Brian F; Knowles, Ian D; Burnstock, Geoffrey; Ramage, Andrew G

2004-06-01

1 The effects of purinoceptor ligands for P2X1 and/or P2X3 receptors (alpha,beta-meATP, IP(5)I, TNP-ATP, MRS 2179, PPADS, Phenol red and RO116-6446/008; i.v., n=4-5) and for P2Y1 receptors (PPADS, MRS 2179 and MRS 2269; i.v., n=3-5) were investigated on the distension-evoked 'micturition reflex' in the urethane-anaesthetized female rat. 2 Alpha,beta-meATP (180 nmol kg(-1) min(-1)), IP5I (10, 30 and 100 nmol kg(-1)), TNP-ATP (1 micromol kg(-1)), MRS 2179 (1 micromol kg(-1)) and PPADS (17 micromol kg(-1)) each caused maintained bladder contractions to occur during the infusion of saline into the bladder. PPADS (17 micromol kg(-1) min(-1)) had a similar effect when infused intravesicularly. Regular bladder contractions were not observed until the infusion of saline was halted. For IP5I, TNP-ATP, MRS 2179 and PPADS, the magnitude of postinfusion isovolumetric contractions was significantly reduced and, for IP5I, this action was also associated with a significant reduction in urethral relaxation. Additionally, TNP-ATP caused a significant increase in the pressure and volume thresholds required to initiate a reflex. 3 Phenol red (a P2X1/P2X3 antagonist; 0.1 and 1 micromol kg(-1)) caused a significant increase in the pressure and volume thresholds required to initiate a reflex and, at the higher dose, also caused a reduction in postinfusion isovolumetric contractions. 4 RO116-6446/008 (a P2X1-selective antagonist; 1 and 10 micromol kg(-1)) only caused a reduction in postinfusion isovolumetric contractions. 5 It is concluded that P2X1 and P2X3 receptors play a fundamental role in the micturition reflex in urethane-anesthetized female rats. P2X3 receptor blockade raised the pressure and volume thresholds for the reflex, whereas P2X1 receptor blockade diminished motor activity associated with voiding. P2Y1 receptors may be involved in inhibition of rat detrusor tone.

Development of the ultrastructure of sonic muscles: a kind of neoteny?

PubMed Central

2014-01-01

Background Drumming muscles of some sound-producing fish are ‘champions’ of contraction speed, their rate setting the fundamental frequency. In the piranha, contraction of these muscles at 150 Hz drives a sound at the same frequency. Drumming muscles of different not closely related species show evolutionary convergences. Interestingly, some characters of sonic muscles can also be found in the trunk muscles of newly hatched larvae that are able to maintain tail beat frequencies up to 100 Hz. The aim of this work was to study the development of sound production and sonic and epaxial muscles simultaneously in the red bellied piranhas (Pygocentrus nattereri) to seek for possible common characteristics. Results Call, pulse and period durations increased significantly with the fish size, but the call dominant frequencies decreased, and the number of pulses and the call amplitude formed a bell curve. In epaxial muscles, the fibre diameters of younger fish are first positioned in the graphical slope corresponding to sonic muscles, before diverging. The fibre diameter of older fish trunk muscles was bigger, and the area of the myofibrils was larger than in sonic muscles. Moreover, in two of the biggest fish, the sonic muscles were invaded by fat cells and the sonic muscle ultrastructure was similar to the epaxial one. These two fish were also unable to produce any sound, meaning they lost their ability to contract quickly. Conclusions The volume occupied by myofibrils determines the force of contraction, the volume of sarcoplasmic reticulum sets the contraction frequency, and the volume of mitochondria sets the level of sustained performance. The functional outcomes in muscles are all attributable to shifts in the proportions of those structures. A single delay in the development restricts the quantity of myofibrils, maintains a high proportion of space in the sarcoplasm and develops sarcoplasmic reticulum. High-speed sonic muscles could thus be skeletal muscles with delayed development. This hypothesis has the advantage that it could easily explain why high-speed sonic muscles have evolved so many times in different lineages. PMID:24507247

Understanding uncertainty in seagrass injury recovery: an information-theoretic approach.

PubMed

Uhrin, Amy V; Kenworthy, W Judson; Fonseca, Mark S

2011-06-01

Vessel groundings cause severe, persistent gaps in seagrass beds. Varying degrees of natural recovery have been observed for grounding injuries, limiting recovery prediction capabilities, and therefore, management's ability to focus restoration efforts where natural recovery is unlikely. To improve our capacity for predicting seagrass injury recovery, we used an information-theoretic approach to evaluate the relative contribution of specific injury attributes to the natural recovery of 30 seagrass groundings in Florida Keys National Marine Sanctuary, Florida, USA. Injury recovery was defined by three response variables examined independently: (1) initiation of seagrass colonization, (2) areal contraction, and (3) sediment in-filling. We used a global model and all possible subsets for four predictor variables: (1) injury age, (2) original injury volume, (3) original injury perimeter-to-area ratio, and (4) wave energy. Successional processes were underway for many injuries with fast-growing, opportunistic seagrass species contributing most to colonization. The majority of groundings that exhibited natural seagrass colonization also exhibited areal contraction and sediment in-filling. Injuries demonstrating colonization, contraction, and in-filling were on average older and smaller, and they had larger initial perimeter-to-area ratios. Wave energy was highest for colonizing injuries. The information-theoretic approach was unable to select a single "best" model for any response variable. For colonization and contraction, injury age had the highest relative importance as a predictor variable; wave energy appeared to be associated with second-order effects, such as sediment in-filling, which in turn, facilitated seagrass colonization. For sediment in-filling, volume and perimeter-to-area ratio had similar relative importance as predictor variables with age playing a lesser role than seen for colonization and contraction. Our findings confirm that these injuries naturally initiate seagrass colonization with the potential to recover to pre-injury conditions, but likely on a decadal scale given the slow growth of the climax species (Thalassia testudinum), which is often the most severely injured. Our analysis supports current perceptions that sediment in-filling is critical to the recovery process and indicates that in order to stabilize injuries and facilitate seagrass recovery, managers should consider immediate restorative filling procedures for injuries having an original volume >14-16 m3.

Systolic ventricular filling.

PubMed

Torrent-Guasp, Francisco; Kocica, Mladen J; Corno, Antonio; Komeda, Masashi; Cox, James; Flotats, A; Ballester-Rodes, Manel; Carreras-Costa, Francesc

2004-03-01

The evidence of the ventricular myocardial band (VMB) has revealed unavoidable coherence and mutual coupling of form and function in the ventricular myocardium, making it possible to understand the principles governing electrical, mechanical and energetical events within the human heart. From the earliest Erasistratus' observations, principal mechanisms responsible for the ventricular filling have still remained obscured. Contemporary experimental and clinical investigations unequivocally support the attitude that only powerful suction force, developed by the normal ventricles, would be able to produce an efficient filling of the ventricular cavities. The true origin and the precise time frame for generating such force are still controversial. Elastic recoil and muscular contraction were the most commonly mentioned, but yet, still not clearly explained mechanisms involved in the ventricular suction. Classical concepts about timing of successive mechanical events during the cardiac cycle, also do not offer understandable insight into the mechanism of the ventricular filling. The net result is the current state of insufficient knowledge of systolic and particularly diastolic function of normal and diseased heart. Here we summarize experimental evidence and theoretical backgrounds, which could be useful in understanding the phenomenon of the ventricular filling. Anatomy of the VMB, and recent proofs for its segmental electrical and mechanical activation, undoubtedly indicates that ventricular filling is the consequence of an active muscular contraction. Contraction of the ascendent segment of the VMB, with simultaneous shortening and rectifying of its fibers, produces the paradoxical increase of the ventricular volume and lengthening of its long axis. Specific spatial arrangement of the ascendent segment fibers, their interaction with adjacent descendent segment fibers, elastic elements and intra-cavitary blood volume (hemoskeleton), explain the physical principles involved in this action. This contraction occurs during the last part of classical systole and the first part of diastole. Therefore, the most important part of ventricular diastole (i.e. the rapid filling phase), in which it receives >70% of the stroke volume, belongs to the active muscular contraction of the ascendent segment. We hope that these facts will give rise to new understanding of the principal mechanisms involved in normal and abnormal diastolic heart function.

48 CFR 552.211-85 - Consistent pack and package requirements.

Code of Federal Regulations, 2010 CFR

2010-10-01

.... If volume warrants, the Government may also order in truckload or carload quantities provided such... change the package quantities. Requests for changes shall be directed to the Contracting Officer or...

Catalytic distillation structure

DOEpatents

Smith, Jr., Lawrence A.

1984-01-01

Catalytic distillation structure for use in reaction distillation columns, a providing reaction sites and distillation structure and consisting of a catalyst component and a resilient component intimately associated therewith. The resilient component has at least about 70 volume % open space and being present with the catalyst component in an amount such that the catalytic distillation structure consist of at least 10 volume % open space.

Noxious stimuli do not determine reflex cardiorespiratory effects in anesthetized rabbits.

PubMed

Raimondi, G; Legramante, J M; Iellamo, F; Frisardi, G; Cassarino, S; Peruzzi, G

1996-12-01

The main purpose of this study is to examine whether the stimulation of an exclusively pain-sensing receptive field (dental pulp) could determine cardiorespiratory effects in animals in which the cortical integration of the peripheral information is abolished by deep anesthesia. In 15 anesthetized (alpha-chloralose and urethan) rabbits, low (3-Hz)- and high-frequency (100-Hz) electrical dental pulp stimulation was performed. Because this stimulation caused dynamic and static reflex contractions of the digastric muscles leading to jaw opening jaw-opening reflex (JOR); an indirect sign of algoceptive fiber activation], experimentally induced direct dynamic and static contractions of the digastric muscle were also performed. The low- and high-frequency stimulation of the dental pulp determined cardiovascular [systolic arterial pressure (SAP): -21.7 +/- 4.6 and 10.8 +/- 4.7 mmHg, respectively] and respiratory [pulmonary ventilation (VE): 145.1 +/- 44.9 and 109.3 +/- 28.4 ml/min, respectively] reflex responses similar to those observed during experimentally induced dynamic (SAP: -17.5 +/- 4.2 mmHg; VE: 228.0 +/- 58.5 ml/min) and static (SAP: 5.8 +/- 1.5 mmHg; VE: 148.0 +/- 75.3 ml/min) muscular contractions. The elimination of digastric muscular contraction (JOR) obtained by muscular paralysis did away with the cardiovascular changes induced by dental pulp stimulation, the effectiveness of which in stimulating dental pulp receptors has been shown by recording trigeminal-evoked potentials in six additional rabbits. The main conclusion was that, in deeply anesthetized animals, an algesic stimulus is unable to determine cardiorespiratory effects, which appear to be exclusively linked to the stimulation of ergoreceptors induced by muscular contraction.

Influence of Crystal Expansion/Contraction on Zeolite Membrane Permeation

DOE Office of Scientific and Technical Information (OSTI.GOV)

Sorenson, Stephanie G; Payzant, E Andrew; Noble, Richard D

X-ray diffraction was used to measure the unit cell parameters of B-ZSM-5, SAPO-34, and NaA zeolite powders as a function of adsorbate loading at 303 K, and in one case, at elevated temperatures. Most adsorbates expanded the zeolite crystals below saturation loading at 303 K: n-hexane and SF6 in B-ZSM-5, methanol and CO2 in SAPO-34, and methanol in NaA zeolite. As the loadings increased, the crystals expanded more. Changes in the unit cell volumes of B-ZSM-5 and SAPO-34 zeolite powders correlated with changes in permeation through zeolite membranes defects. When the zeolite crystals expanded or contracted upon adsorption, the defectmore » sizes decreased or increased. In B-ZSM-5 membranes, the fluxes through defects decreased dramatically when n-hexane or SF6 adsorbed. In contrast, i-butane adsorption at 303 K contracted B-ZSM-5 crystals at low loadings and expanded them at higher loadings. Correspondingly, the flux through B-ZSM-5 membrane defects increased at low i-butane loadings and decreased at high loading because the defects increased in size at low loading and decreased at high loadings. At 398 K and 473 K, n-hexane expanded the B-ZSM-5 unit cell more as the temperature increased from 303 to 473 K. The silicalite-1 and B-ZSM-5 unit cell volumes expanded similarly upon n-hexane adsorption at 303 K; boron substitution had little effect on volume expansion.« less

A new proposal to evaluate the healing of open skin wounds: volumetry.

PubMed

Paulo, Danilo Nagib Salomão; Fiorot, Antonio Wilson

2011-12-01

To present a new proposal to evaluate the healing of an open subcutaneous and skin wound, which we termed "volumetry". A total of 32 circular wounds were performed in the subcutaneous tissues and skin of four feet of pigs (8 each). Each wound had about 1 cm in diameter and was 0.2 cm deep. Volume was calculated from the wound filled with saline and mass Xantopren. With the aid of a magnifying glass and local lighting, the liquid was dripped with a micropipette inside the wound until complete fullness. Volume repletion was calculated in microliters, corresponding to the volume of the wound. The mass of Xantopren was placed inside the wound to obtain a mold of the lesion. Mold volume was calculated using the formula of the volume of a cylinder closest resembling a geometric figure with mold. The calculation of wound volume was possible with both Xantopren and mold techniques. Volume as calculated by micropipette was 119.37 ± 30.87 microliters while the volume calculated by mold was 122.41 ± 33.90 mm3 (p=0.79). Volumetry in pig feet is simple and reproducible. Volumetry perfomed with saline did not differ from the volumetry with mass Xantopren. This method may be a useful tool to help evaluate the healing of open skin wounds in experimental and clinical research.

Closed-loop mechanical ventilation for lung injury: a novel physiological-feedback mode following the principles of the open lung concept.

PubMed

Schwaiberger, David; Pickerodt, Philipp A; Pomprapa, Anake; Tjarks, Onno; Kork, Felix; Boemke, Willehad; Francis, Roland C E; Leonhardt, Steffen; Lachmann, Burkhard

2018-06-01

Adherence to low tidal volume (V T ) ventilation and selected positive end-expiratory pressures are low during mechanical ventilation for treatment of the acute respiratory distress syndrome. Using a pig model of severe lung injury, we tested the feasibility and physiological responses to a novel fully closed-loop mechanical ventilation algorithm based on the "open lung" concept. Lung injury was induced by surfactant washout in pigs (n = 8). Animals were ventilated following the principles of the "open lung approach" (OLA) using a fully closed-loop physiological feedback algorithm for mechanical ventilation. Standard gas exchange, respiratory- and hemodynamic parameters were measured. Electrical impedance tomography was used to quantify regional ventilation distribution during mechanical ventilation. Automatized mechanical ventilation provided strict adherence to low V T -ventilation for 6 h in severely lung injured pigs. Using the "open lung" approach, tidal volume delivery required low lung distending pressures, increased recruitment and ventilation of dorsal lung regions and improved arterial blood oxygenation. Physiological feedback closed-loop mechanical ventilation according to the principles of the open lung concept is feasible and provides low tidal volume ventilation without human intervention. Of importance, the "open lung approach"-ventilation improved gas exchange and reduced lung driving pressures by opening atelectasis and shifting of ventilation to dorsal lung regions.

48 CFR 706.302-5 - Authorized or required by statute.

Code of Federal Regulations, 2014 CFR

2014-10-01

... DEVELOPMENT ACQUISITION PLANNING COMPETITION REQUIREMENTS Other Than Full and Open Competition 706.302-5 Authorized or required by statute. Certain annual appropriations acts authorize USAID to contract with...

48 CFR 706.302-5 - Authorized or required by statute.

Code of Federal Regulations, 2010 CFR

2010-10-01

... DEVELOPMENT ACQUISITION PLANNING COMPETITION REQUIREMENTS Other Than Full and Open Competition 706.302-5 Authorized or required by statute. Certain annual appropriations acts authorize USAID to contract with...

48 CFR 706.302-5 - Authorized or required by statute.

Code of Federal Regulations, 2013 CFR

2013-10-01

... DEVELOPMENT ACQUISITION PLANNING COMPETITION REQUIREMENTS Other Than Full and Open Competition 706.302-5 Authorized or required by statute. Certain annual appropriations acts authorize USAID to contract with...

48 CFR 706.302-5 - Authorized or required by statute.

Code of Federal Regulations, 2012 CFR

2012-10-01

... DEVELOPMENT ACQUISITION PLANNING COMPETITION REQUIREMENTS Other Than Full and Open Competition 706.302-5 Authorized or required by statute. Certain annual appropriations acts authorize USAID to contract with...

48 CFR 706.302-5 - Authorized or required by statute.

Code of Federal Regulations, 2011 CFR

2011-10-01

... DEVELOPMENT ACQUISITION PLANNING COMPETITION REQUIREMENTS Other Than Full and Open Competition 706.302-5 Authorized or required by statute. Certain annual appropriations acts authorize USAID to contract with...

7 CFR 1753.93 - Responsibilities.

Code of Federal Regulations, 2010 CFR

2010-01-01

...) Approval of field trials. (9) Approval to modify or alter standard forms and contracts. (10) Approval to open bids when fewer than the required number have been received. (11) Approval of outside plant...

Effects of pico-tesla electromagnetic field treatment on wound healing in rats.

PubMed

Trostel, C Todd; McLaughlin, Ron M; Lamberth, John G; Cooper, Robert C; Elder, Steven H; Pool, Roy R; Gao, Cheng; Cromiak, Joseph A; Boyle, Carolyn R

2003-07-01

To evaluate the effects of a pico-tesla electromagnetic field (PTEF) on healing of sutured and open skin wounds and clinicopathologic variables in rats. 64 male Fischer-344 rats. An incision made in the dorsal aspect of the neck was sutured (n = 32) or left open to heal (32). In each group, 16 rats were not PTEF-treated (controls). Wound treatment consisted of exposure to a PTEF once daily. Rats in each group were euthanatized at days 2, 4, 7, and 14. Wounds were evaluated via tensiometry (sutured wounds), digital planimetry (open wounds), laser Doppler perfusion imaging, bacteriologic culture, and histologic examination. Blood samples were collected from all rats for analysis. At day 14, sutured wounds in PTEF-treated rats were stronger (ultimate stress) and tougher (strain energy) than were sutured wounds in control rats. Open wounds in PTEF-treated rats contracted more quickly at days 2 and 4 than did those in control rats. Compared with control wounds, histologic changes (indicative of improved healing) in sutured and open wounds in PTEF-treated rats were detected as early as day 4. Laser Doppler perfusion measurements, results of CBCs, serum biochemical analyses, and bacteriologic cultures were not different between groups. Exposure to the PTEF caused no adverse effects on clinicopathologic, histologic, or bacteriologic variables tested in this study. It appears that PTEF is a safe form of adjuvant treatment for wounds and improves strength of sutured wounds and speeds contraction of open wounds.

Development of Methods to Account for HCl and Cl2 from Open Burning and Characterization of Emissions from the Open Burning of Three Selected Propellants

DTIC Science & Technology

1996-09-01

Burning of Three Selected Propellants 6. AUTHOR(S) J.L Wilcox, B. Entezam, M.J. Molenaar , & T.R. Shreeve 7. PERFORMING ORGANIZATION NAME(S) AND ADDRESS...Physical Test Division West Desert Test Center Ben Entezam Michael J Molenaar Thomas Russell Shreeve Andrulis Research Corporation Contract No. DAAD09

Evaluation of Contracting and Production Activities at: The Defense Logistics Agency’s Defense Supply Centers. Volume 3. Defense Personnel Support Center Review.

DTIC Science & Technology

1984-03-01

with GAO; GAO sustained only 1. The Maybank Amendment also complicates both the bidding and award process. Normally, the DoD Appropriation Act...precludes DoD from paying a price differential on contracts awarded for labor surplus area (LSA) set-asides. This restriction, known as the Maybank Amendment...personnel believe that the frequency of bid protests has increased as a consequence of the bidding complica- tions introduced by the Maybank revision

Function algorithms for MPP scientific subroutines, volume 1

NASA Technical Reports Server (NTRS)

Gouch, J. G.

1984-01-01

Design documentation and user documentation for function algorithms for the Massively Parallel Processor (MPP) are presented. The contract specifies development of MPP assembler instructions to perform the following functions: natural logarithm; exponential (e to the x power); square root; sine; cosine; and arctangent. To fulfill the requirements of the contract, parallel array and solar implementations for these functions were developed on the PDP11/34 Program Development and Management Unit (PDMU) that is resident at the MPP testbed installation located at the NASA Goddard facility.

Defense Small Business Innovation Research Program (SBIR). Volume 4. Defense Agencies Abstracts of Phase 1 Awards from FY 1988 SBIR Solicitation

DTIC Science & Technology

1989-05-01

FORMULATION -- FLOQUET-GALERKIN. DELPHI RESEARCH INC 701 HAINES AVE NW ALBUQUERQUE, NM 87102 CONTRACT NUMBER: PATRICK M DHOOGE TITLE: RESEARCH ON A...MEASURE THE DIELECTRIC RESPONSE OF A DIAMOND FILM AS IT GROWNS. DIESEL DYNE CORP 3044 MIDDLEBORO RD MORROW, OH 45152 CONTRACT NUMBER: RICHARD P JOHNSTON...TITLE: A STUDY OF AN ADVANCED VARIABLE CYCLE DIESEL ENGINE FOR USE IN A REMOTELY PILOTED VEHICLE TOPIC# 18 OFFICE: ASTO IDENT#: 22796 THIS STUDY IS

Aircraft Engine Nacelle Fire Test Simulator. Volume I. Technical.

DTIC Science & Technology

1980-04-01

THIS IPAa@f[h Daal 3MatfeeJ V .. . . .. --.-- - - -- , • PREFACE This report documents the results of the work efforts under Contract No. F33615-76-C...overview of the simulator and its associated equipment capabilities, as compared to the Contract Work Statement performance goals and baseline concepts, is...duct where it pene- trates the roof, and then transitions into a 18" x 36" rectangular cross section of equal area against the east wall of I-Bay. This

Issues in NASA program and project management

NASA Technical Reports Server (NTRS)

Hoban, Francis T. (Editor)

1990-01-01

This volume is the third in an ongoing series on aerospace project management at NASA. Articles in this volume cover the attitude of the program manager, program control and performance measurement, risk management, cost plus award fee contracting, lessons learned from the development of the Far Infrared Absolute Spectrometer (FIRAS), small projects management, and age distribution of NASA scientists and engineers. A section on resources for NASA managers rounds out the publication.

Issues in NASA program and project management

NASA Technical Reports Server (NTRS)

Hoban, Francis T. (Editor)

1991-01-01

This volume is the third in an ongoing series on aerospace project management at NASA. Articles in this volume cover the attitude of the program manager, program control and performance measurement, risk management, cost plus award fee contracting, lessons learned from the development of the Far Infrared Absolute Spectrometer (FIRAS), small projects management, and age distribution of NASA scientists and engineers. A section on resources for NASA managers rounds out the publication.

Phase 2 Site Investigations Report. Volume 3 of 3: Appendices

DTIC Science & Technology

1994-09-01

Phase II Site Investigations Ee Report Cn Volume III of III Appendices Fort Devens Sudbury Training Annex, Massachusetts September 1994 Contract No...laboratory quality control (QC) samples collected during field investigations at the Sudbury Training Annex of Fort Devens , Massachusetts. The QC...returned to its original condition. E & E performed this procedure for each monitoring well tested during the 1993 slug testing activities at Fort Devens

Image of a moving sphere and the FitzGerald Lorentz contraction

NASA Astrophysics Data System (ADS)

Redzic, Dragan V.

2004-01-01

An asymmetry in Maxwell's electrodynamics concerning the electromagnetic image of a moving spherical conductor is pointed out. The asymmetry, if properly understood, opens the door to special relativity.

Early Warnings for Local Labor Markets

ERIC Educational Resources Information Center

Matland, Marc A.

1976-01-01

This articles summarizes the National Planning Association's (NPA) experience in its initial efforts to develop an early warning system to anticipate job openings generated in local communities by large Federal procurement contracts. (WL)

The Electrophysiologic Effects of Acute Mitral Regurgitation in a Canine Model.

PubMed

Lawrance, Christopher P; Henn, Matthew C; Miller, Jacob R; Kopek, Michael A; Zhang, Andrew J; Schuessler, Richard B; Damiano, Ralph J

2017-04-01

Atrial fibrillation (AF) occurs in 30% of patients with mitral regurgitation referred for surgical intervention. However, the underlying mechanisms in this population are poorly understood. This study examined the effects of acute left atrial volume overload on atrial electrophysiology and the inducibility of AF. Ten canines underwent insertion of an atrioventricular shunt between the left ventricle and left atrium. Shunt and aortic flows were calculated, and the shunt was titrated to a shunt fraction to 40% to 50% of cardiac output. An epicardial plaque with 250 bipolar electrodes was used to determine activation and refractory periods. Biatrial pressures and volumes, conduction times, and atrial fibrillation inducibility were recorded. Data were collected at baseline and 20 minutes after shunt opening and closure. Mean shunt flow was 1.3 ± 0.5 L/min with a shunt fraction of 43% ± 6% simulating moderate to severe mitral regurgitation. Compared with baseline, left atrial volumes and maximum pressures increased by 27% and 29%, respectively, after shunt opening. Biatrial effective refractory periods did not change significantly after shunt opening or closure. Conduction times increased by 9% with shunt opening and returned to baseline after closure. AF duration or inducibility did not change with shunt opening. This canine model of mitral regurgitation demonstrated that acute left atrial volume overload did not increase the inducibility of atrial arrhythmias in contrast with experimental and clinical findings of chronic left atrial volume overload. This suggests that the substrates for AF in patients with mitral regurgitation are a result of chronic remodeling. Copyright © 2017 The Society of Thoracic Surgeons. Published by Elsevier Inc. All rights reserved.

Volume change associated with formation and dissociation of hydrate in sediment

USGS Publications Warehouse

Ruppel, Carolyn D.; Lee, J.Y.; Santamarina, J. Carlos

2017-01-01

Gas hydrate formation and dissociation in sediments are accompanied by changes in the bulk volume of the sediment and can lead to changes in sediment properties, loss of integrity for boreholes, and possibly regional subsidence of the ground surface over areas where methane might be produced from gas hydrate in the future. Experiments on sand, silts, and clay subject to different effective stress and containing different saturations of hydrate formed from dissolved phase tetrahydrofuran are used to systematically investigate the impact of gas hydrate formation and dissociation on bulk sediment volume. Volume changes in low specific surface sediments (i.e., having a rigid sediment skeleton like sand) are much lower than those measured in high specific surface sediments (e.g., clay). Early hydrate formation is accompanied by contraction for all soils and most stress states in part because growing gas hydrate crystals buckle skeletal force chains. Dilation can occur at high hydrate saturations. Hydrate dissociation under drained, zero lateral strain conditions is always associated with some contraction, regardless of soil type, effective stress level, or hydrate saturation. Changes in void ratio during formation-dissociation decrease at high effective stress levels. The volumetric strain during dissociation under zero lateral strain scales with hydrate saturation and sediment compressibility. The volumetric strain during dissociation under high shear is a function of the initial volume average void ratio and the stress-dependent critical state void ratio of the sediment. Other contributions to volume reduction upon hydrate dissociation are related to segregated hydrate in lenses and nodules. For natural gas hydrates, some conditions (e.g., gas production driven by depressurization) might contribute to additional volume reduction by increasing the effective stress.

Catalytic distillation structure

DOEpatents

Smith, L.A. Jr.

1984-04-17

Catalytic distillation structure is described for use in reaction distillation columns, and provides reaction sites and distillation structure consisting of a catalyst component and a resilient component intimately associated therewith. The resilient component has at least about 70 volume % open space and is present with the catalyst component in an amount such that the catalytic distillation structure consists of at least 10 volume % open space. 10 figs.

Coarse woody debris in managed central hardwood forests of Indiana, USA

Treesearch

Michael A. Jenkins; Christopher R. Webster; George R. Parker; Martin A. Spetich

2004-01-01

We evaluated the volume of down deadwood (DDW) and the basal area of standing deadwood (SDW) from a chronosequence of 110 silvicultural openings and 34 mature stands (72-105 years old) across three Ecological Landtype Phases (ELTP; wet-mesic bottomlands, mesic slopes, and dry-mesic slopes) in southern Indiana, USA. The volume of DDW decreased with increasing opening...

Positron beam study of indium tin oxide films on GaN

NASA Astrophysics Data System (ADS)

Cheung, C. K.; Wang, R. X.; Beling, C. D.; Djurisic, A. B.; Fung, S.

2007-02-01

Variable energy Doppler broadening spectroscopy has been used to study open-volume defects formed during the fabrication of indium tin oxide (ITO) thin films grown by electron-beam evaporation on n-GaN. The films were prepared at room temperature, 200 and 300 °C without oxygen and at 200 °C under different oxygen partial pressures. The results show that at elevated growth temperatures the ITO has fewer open volume sites and grows with a more crystalline structure. High temperature growth, however, is not sufficient in itself to remove open volume defects at the ITO/GaN interface. Growth under elevated temperature and under partial pressure of oxygen is found to further reduce the vacancy type defects associated with the ITO film, thus improving the quality of the film. Oxygen partial pressures of 6 × 10-3 mbar and above are found to remove open volume defects associated with the ITO/GaN interface. The study suggests that, irrespective of growth temperature and oxygen partial pressure, there is only one type of defect in the ITO responsible for trapping positrons, which we tentatively attribute to the oxygen vacancy.

48 CFR 1852.236-75 - Partnering for construction contracts.

Code of Federal Regulations, 2010 CFR

2010-10-01

... “partnership” used herein shall mean a relationship of open communication and close cooperation that involves... development and team building workshop. Follow-up team building workshops will be held periodically throughout...

13 CFR 126.600 - What are HUBZone contracts?

Code of Federal Regulations, 2010 CFR

2010-01-01

... qualified HUBZone SBC through any of the following procurement methods: (a) Sole source awards to qualified...) Awards to qualified HUBZone SBCs through full and open competition after a price evaluation preference in...

The role of elastic restoring forces in right-ventricular filling

PubMed Central

Pérez Del Villar, Candelas; Bermejo, Javier; Rodríguez-Pérez, Daniel; Martínez-Legazpi, Pablo; Benito, Yolanda; Antoranz, J. Carlos; Desco, M. Mar; Ortuño, Juan E.; Barrio, Alicia; Mombiela, Teresa; Yotti, Raquel; Ledesma-Carbayo, Maria J.; Del Álamo, Juan C.; Fernández-Avilés, Francisco

2015-01-01

Aims The physiological determinants of RV diastolic function remain poorly understood. We aimed to quantify the contribution of elastic recoil to RV filling and determine its sensitivity to interventricular interaction. Methods and results High-fidelity pressure–volume loops and simultaneous 3-dimensional ultrasound sequences were obtained in 13 pigs undergoing inotropic modulation, volume overload, and acute pressure overload induced by endotoxin infusion. Using a validated method, we isolated elastic restoring forces from ongoing relaxation using conventional pressure–volume data. The RV contracted below the equilibrium volume in >75% of the data sets. Consequently, elastic recoil generated strong sub-atmospheric passive pressure at the onset of diastole [−3 (−4 to −2) mmHg at baseline]. Stronger restoring suction pressure was related to a shorter isovolumic relaxation period, a higher rapid filling fraction, and lower atrial pressures (all P < 0.05). Restoring forces were mostly determined by the position of operating volumes around the equilibrium volume. By this mechanism, the negative inotropic effect of beta-blockade reduced and sometimes abolished restoring forces. During acute pressure overload, restoring forces initially decreased, but recovered at advanced stages. This biphasic response was related to alterations of septal curvature induced by changes in the diastolic LV–RV pressure balance. The constant of elastic recoil was closely related to the constant of passive stiffness (R = 0.69). Conclusion The RV works as a suction pump, exploiting contraction energy to facilitate filling by means of strong elastic recoil. Restoring forces are influenced by the inotropic state and RV conformational changes mediated by direct ventricular interdependence. PMID:25691537

Comments on new multiple-brane solutions based on Hata-Kojita duality in open string field theory

NASA Astrophysics Data System (ADS)

Masuda, Toru

2014-05-01

Recently, Hata and Kojita proposed a new energy formula for a class of solutions in Witten's open string field theory based on a novel symmetry of correlation functions they found. Their energy formula can be regarded as a generalization of the conventional energy formula by Murata and Schnabl. Following their proposal, we investigate their new ansatz for the classical solution representing double D-branes. We present a regularized definition of this solution and show that the solution satisfies the equation of motion when it is contracted with the solution itself and when it is contracted with any states in the Fock space. However, the Ellwood invariant and the boundary state of the solution are the same as those for the perturbative vacuum. This result disagrees with an expectation from the Ellwood conjecture.

Asphaltene-laden interfaces form soft glassy layers in contraction experiments: a mechanism for coalescence blocking.

PubMed

Pauchard, Vincent; Rane, Jayant P; Banerjee, Sanjoy

2014-11-04

In previous studies, the adsorption kinetics of asphaltenes at the water-oil interface were interpreted utilizing a Langmuir equation of state (EOS) based on droplet expansion experiments.1-3 Long-term adsorption kinetics followed random sequential adsorption (RSA) theory predictions, asymptotically reaching ∼85% limiting surface coverage, which is similar to limiting random 2D close packing of disks. To extend this work beyond this slow adsorption process, we performed rapid contractions and contraction-expansions of asphaltene-laden interfaces using the pendant drop experiment to emulate a Langmuir trough. This simulates the rapid increase in interfacial asphaltene concentration that occurs during coalescence events. For the contraction of droplets aged in asphaltene solutions, deviation from the EOS consistently occurs at a surface pressure value ∼21 mN/m corresponding to a surface coverage ∼80%. At this point droplets lose the shape required for validity of the Laplace-Young equation, indicating solidlike surface behavior. On further contraction wrinkles appear, which disappear when the droplet is held at constant volume. Surface pressure also decreases down to an equilibrium value near that measured for slow adsorption experiments. This behavior appears to be due to a transition to a glassy interface on contraction past the packing limit, followed by relaxation toward equilibrium by desorption at constant volume. This hypothesis is supported by cycling experiments around the close-packed limit where the transition to and from a solidlike state appears to be both fast and reversible, with little hysteresis. Also, the soft glass rheology model of Sollich is shown to capture previously reported shear behavior during adsorption. The results suggest that the mechanism by which asphaltenes stabilize water-in-oil emulsions is by blocking coalescence due to rapid formation of a glassy interface, in turn caused by interfacial asphaltenes rapidly increasing in concentration beyond the glass transition point.

Learning process for performing and analyzing 3D/4D transperineal ultrasound imaging and interobserver reliability study.

PubMed

Siafarikas, F; Staer-Jensen, J; Braekken, I H; Bø, K; Engh, M Ellström

2013-03-01

To evaluate the learning process for acquiring three- and four-dimensional (3D/4D) transperineal ultrasound volumes of the levator hiatus (LH) dimensions at rest, during pelvic floor muscle (PFM) contraction and on Valsalva maneuver, and for analyzing the ultrasound volumes, as well as to perform an interobserver reliability study between two independent ultrasound examiners. This was a prospective study including 22 women. We monitored the learning process of an inexperienced examiner (IE) performing 3D/4D transperineal ultrasonography and analyzing the volumes. The examination included acquiring volumes during three PFM contractions and three Valsalva maneuvers. LH dimensions were determined in the axial plane. The learning process was documented by estimating agreement between the IE and an experienced examiner (E) using the intraclass correlation coefficient. Agreement was calculated in blocks of 10 ultrasound examinations and analyzed volumes. After the learning process was complete the interobserver reliability for the technique was calculated between these two independent examiners. For offline analysis of the first 10 ultrasound volumes obtained by E, good to very good agreement between E and IE was achieved for all LH measurements except for the left and right levator-urethra gap and pubic arc. For the next 10 analyzed volumes, agreement improved for all LH measurements. Volumes that had been obtained by IE and E were then re-evaluated by IE, and good to very good agreement was found for all LH measurements indicating consistency in volume acquisition. The interobserver reliability study showed excellent ICC values (ICC, 0.81-0.97) for all LH measurements except the pubic arc (ICC = 0.67). 3D/4D transperineal ultrasound is a reliable technique that can be learned in a short period of time. Copyright © 2012 ISUOG. Published by John Wiley & Sons, Ltd.

Effect of Power Exchange of India: An Overview and Key Issues

NASA Astrophysics Data System (ADS)

Singh, A.; Chauhan, D. S.; Upadhdhyay, K. G.

2013-09-01

There stands no guarantee that if potential market participants are simply provided with the opportunity for trading electricity, there shall be an efficient wholesale electricity market. India, as well as various other developed countries, relies on voluntary agreements as far as electricity trading is concerned. Self, private initiatives to standardize and commodities contracts play an important role in increasing the trading volume to improve efficiency, in developed countries. In accordance with their experiences, this paper suggested a specific strategy to promote bilateral/OTC trading; hence, India needed to develop a master agreement for electricity contracts. This paper discusses that the creating power exchange for short-term trading in the spot market materializing the contract for the convenience of market participants stands particularly important and henceforth is a necessary factor to make sure that spot market is workable and competitive prior to developing a financial contract for electricity trading.

EFFECT OF MASSIVE NEUTRON EXPOSURE ON THE DISTORTION OF REACTOR GRAPHITE

DOE Office of Scientific and Technical Information (OSTI.GOV)

Helm, J.W.; Davidson, J.M.

1963-05-28

Distortion of reactor-grade graphites was studied at varying neutron exposures ranging up to 14 x 10/sup 21/ neutrons per cm/sup 2/ (nvt)/sup */ at temperatures of irradiation ranging from 425 to 800 deg C. This exposure level corresponds to approximately 100,000 megawatt days per adjacent ton of fuel (Mwd/ At) in a graphite-moderated reactor. A conventionalcoke graphite, CSF, and two needle-coke graphites, NC-7 and NC-8, were studied. At all temperatures of irradiation the contraction rate of the samples cut parallel to the extrusion axis increased with increasing neutron exposure. For parallel samples the needle- coke graphites and the CSF graphitemore » contracted approximately the same amount. In the transverse direction the rate of cortraction at the higher irradiation temperntures appeared to be decreasing. Volume contractions derived from the linear contractions are discussed. (auth)« less

Compound refractive X-ray lens

DOEpatents

Nygren, David R.; Cahn, Robert; Cederstrom, Bjorn; Danielsson, Mats; Vestlund, Jonas

2000-01-01

An apparatus and method for focusing X-rays. In one embodiment, his invention is a commercial-grade compound refractive X-ray lens. The commercial-grade compound refractive X-ray lens includes a volume of low-Z material. The volume of low-Z material has a first surface which is adapted to receive X-rays of commercially-applicable power emitted from a commercial-grade X-ray source. The volume of low-Z material also has a second surface from which emerge the X-rays of commercially-applicable power which were received at the first surface. Additionally, the commercial-grade compound refractive X-ray lens includes a plurality of openings which are disposed between the first surface and the second surface. The plurality of openings are oriented such that the X-rays of commercially-applicable power which are received at the first surface, pass through the volume of low-Z material and through the plurality openings. In so doing, the X-rays which emerge from the second surface are refracted to a focal point.

CT imaging during microwave ablation: Analysis of spatial and temporal tissue contraction

DOE Office of Scientific and Technical Information (OSTI.GOV)

Liu, Dong; Brace, Christopher L., E-mail: clbrace@wisc.edu

Purpose: To analyze the spatial distribution and temporal development of liver tissue contraction during high-temperature ablation by using intraprocedural computed tomography (CT) imaging. Methods: A total of 46 aluminum fiducial markers were positioned in a 60 × 45 mm grid, in a single plane, around a microwave ablation antenna in each of six ex vivo bovine liver samples. Ablations were performed for 10 min at 100 W. CT data of the liver sample were acquired every 30 s during ablation. Fiducial motion between acquisitions was tracked in postprocessing and used to calculate measures of tissue contraction and contraction rates. Themore » spatial distribution and temporal evolution of contraction were analyzed. Results: Fiducial displacement indicated that the zone measured postablation was 8.2 ± 1.8 mm (∼20%) smaller in the radial direction and 7.1 ± 1.0 mm (∼10%) shorter in the longitudinal direction than the preablation tissue dimension. Therefore, the total ablation volume was reduced from its preablation value by approximately 45%. Very little longitudinal contraction was noted in the distal portion of the ablation zone. Central tissues contracted more than 60%, which was near an estimated limit of ∼70% based on initial water content. More peripheral tissues contracted only 15% in any direction. Contraction rates peaked during the first 60 s of heating with a roughly exponential decay over time. Conclusions: Ablation zones measured posttreatment are significantly smaller than the pretreatment tissue dimensions. Tissue contraction is spatially dependent, with the greatest effect occurring in the central ablation zone. Contraction rate peaks early and decays over time.« less

Savannah River Plant engineering, design, and construction history of ``S`` projects and other work, January 1961--December 1964. Volume 2

DOE Office of Scientific and Technical Information (OSTI.GOV)

Not Available

1970-03-01

The work described in this volume of ``S`` Projects History is an extension of the type of work described in Volume I. E.I. du Pont de flemours & Company had entered into Contract AT (07-2)-l with the United States Atomic Energy Commission to develop, design, construct, install, and operate facilities to produce heavy water, fissionable materials, and related products. Under this contract,, Du Pont constructed and operated the Savannah River Plant. The engineering, design, and construction for most of the larger ``S`` projects was performed by the Engineering DeDartment. For some of the large and many of the smaller projectsmore » the Engineering Department was responsible only for the construction because the Atomic Energy Division (AED) of the Explosives Department handled the other phases. The Engineering Department Costruction Division also performed the physical work for many of the plant work orders. This volume includes a general description of the Du Pont Engineering Department activities pertaining to the engineering, design, and construction of the ``S`` projects at the Savannah River Plant; brief summaries of the projects and principal work requests; and supplementary informaticn on a few subjects in Volume I for which final data was not available at the closing date. Projects and other plant engineering work which were handled entirely by the Explosives Department -- AED are not included in this history.« less

Balloons and Bottles: Activities on Air-Sea Heat Exchange.

ERIC Educational Resources Information Center

Murphree, Tom

1998-01-01

Presents an activity designed to demonstrate how heating and cooling an air mass affects its temperature, volume, density, and pressure. Illustrates how thermal energy can cause atmospheric motion such as expansion, contraction, and winds. (Author/WRM)

Abdomino-phrenic dyssynergia in patients with abdominal bloating and distension.

PubMed

Villoria, Albert; Azpiroz, Fernando; Burri, Emanuel; Cisternas, Daniel; Soldevilla, Alfredo; Malagelada, Juan-R

2011-05-01

The abdomen normally accommodates intra-abdominal volume increments. Patients complaining of abdominal distension exhibit abnormal accommodation of colonic gas loads (defective contraction and excessive protrusion of the anterior wall). However, abdominal imaging demonstrated diaphragmatic descent during spontaneous episodes of bloating in patients with functional gut disorders. We aimed to establish the role of the diaphragm in abdominal distension. In 20 patients complaining of abdominal bloating and 15 healthy subjects, we increased the volume of the abdominal cavity with a colonic gas load, while measuring abdominal girth and electromyographic activity of the anterior abdominal muscles and of the diaphragm. In healthy subjects, the colonic gas load increased girth, relaxed the diaphragm, and increased anterior wall tone. With the same gas load, patients developed significantly more abdominal distension; this was associated with paradoxical contraction of the diaphragm and relaxation of the internal oblique muscle. In this experimental provocation model, abnormal accommodation of the diaphragm is involved in abdominal distension.

Towards an Artificial Space Object Taxonomy

DTIC Science & Technology

2013-09-01

demonstrate how to implement this taxonomy in Figaro, an open source probabilistic programming language. 2. INTRODUCTION Currently, US Space Command...Taxonomy 5a. CONTRACT NUMBER 5b. GRANT NUMBER 5c. PROGRAM ELEMENT NUMBER 6. AUTHOR(S) 5d. PROJECT NUMBER 5e. TASK NUMBER 5f. WORK UNIT NUMBER 7...demonstrate how to implement this taxonomy in Figaro, an open source probabilistic programming language. 15. SUBJECT TERMS 16. SECURITY CLASSIFICATION OF

It Is Time to Cancel Medicine's Social Contract Metaphor.

PubMed

Harris, John M

2017-09-01

There is agreement that the complex relationship between medicine and society is best described as a metaphorical social contract and that professionalism is the medical profession's contribution to this contract. Metaphors can help clarify abstract concepts, but they can also be abused if the counterfactual attributes of a metaphor become attributed to its subject. This seems to be happening with medical professionalism, which has sometimes been reduced to a contracted deliverable and a bargaining chip. The undesirable attributes of the social contract metaphor may be hindering efforts to understand and teach medical professionalism.Despite its theoretical weaknesses, the social contract metaphor has historical credibility because of its alleged association with the 1847 Code of Medical Ethics and the subsequent ascension of regular (allopathic) medicine in the early 20th century. However, the record does not support an argument that the intended purpose of the 1847 Code was to create a social contract or that one ever arose. The alternative account that a contract did arise, but physicians were poor partners, is neither satisfying nor explanatory.As now used, medicine's social contract metaphor has serious theoretical and historic weaknesses. Medical educators should remove this narrow and overworked metaphor from their discussions of professionalism. By doing this, educators and the profession in general would only lose the ability to threaten themselves with the cancellation of their social contract. In return they would open the door to a more complex and fruitful consideration of medical professionalism and medicine's relationship with society.

Design for Production Manual. Volume 2. Design/Production Integration

DTIC Science & Technology

1985-12-01

woodworking equipment such as circular saw, cross cut saw, planer / thicknesser and sander. There is considerable use of hand tools in the shop. Joinery inclucies...PROGRAM BY SOCIETY OF NAVAL ARCHITECTS AND MARINE ENGINEERS SHIP PRODUCTION COMMITTEE PANEL SP- 4 DESIGN PRODUCTION INTEGRATION CONTRACT DTMA91-82-C...DEC 1985 2. REPORT TYPE N/A 3. DATES COVERED - 4 . TITLE AND SUBTITLE Design for Production Manual Volume 2 of 3 Design/Production

Collaborative Multidisciplinary Sciences for Analysis and Design of Aerospace Vehicles. Volume 1

DTIC Science & Technology

2017-05-01

AEROSPACE VEHICLES Volume 1 5a. CONTRACT NUMBER FA8650-09-2-3938 5b. GRANT NUMBER 5c. PROGRAM ELEMENT NUMBER 62201F 6. AUTHOR(S) Raymond M...S) AND ADDRESS(ES) 8. PERFORMING ORGANIZATION REPORT NUMBERDesign and Analysis Branch (AFRL/RQVC) Aerospace Vehicles Division Air Force Research...Laboratory, Aerospace Systems Directorate Wright-Patterson Air Force Base, OH 45433-7542 Air Force Materiel Command, United States Air Force Virginia

Influence of Very High Breathing Resistance on Exercise Tolerance, Part 1 - Dry Exercise

DTIC Science & Technology

2016-01-01

Influence of Very High Breathing Resistance on Exercise Tolerance, Part 1 – Dry Exercise Authors...Tolerance, Part 1 – Dry Exercise 5a. CONTRACT NUMBER 5b. GRANT NUMBER 5c. PROGRAM ELEMENT NUMBER 6. AUTHOR(S) Warkander D...exercise (60% of peak O2 consumption) on a cycle ergometer on dry land at sea level. R was such that the work of breathing per volume (volume-averaged

Method and apparatus for preloading a joint by remotely operable means

NASA Technical Reports Server (NTRS)

Kahn, Jon B. (Inventor)

1993-01-01

The invention is a method and apparatus for joining structures, an active structure and a passive structure, and imposing a tensile pre-load on the joint by a remotely operable mechanism comprising a heat contractible joining element. The method and apparatus include mounting on the structure, a probe shaft of material which is transformable from an expanded length to a contracted length when heated to a specific temperature range. The shaft is provided with a probe head which is receivable in a receptacle opening formed in the passive structure, when the active structure is moved into engagement therewith by an appropriate manipulator mechanism. A latching system mounted on the structure adjacent to the receptacle opening captures the probe head, when the probe head is inserted a predetermined amount. A heating coil on the shaft is energizable by remote control for heating the shaft to a temperature range which transforms the shaft to its contracted length, whereby a latching shoulder thereof engages latching elements of the latching system and imposes a tensile preload on the structural joint. Provision is also made for manually adjusting the probe head on the shaft to allow for manual detachment of the structures or manual preloading of the structural joint.

Method and apparatus for preloading a joint by remotely operable means

NASA Technical Reports Server (NTRS)

Shelton, Robert O. (Inventor)

1992-01-01

The invention is a method and apparatus for joining structures, an active structure and a passive structure, and imposing a tensile pre-load on the joint by a remotely operable mechanism comprising a heat contractible joining element. The method and apparatus include mounting on the structure, a probe shaft of material which is transformable from an expanded length to a contracted length when heated to a specific temperature range. The shaft is provided with a probe head which is receivable in a receptacle opening formed in the passive structure, when the active structure is moved into engagement therewith by an appropriate manipulator mechanism. A latching system mounted on the structure adjacent to the receptacle opening captures the probe head, when the probe head is inserted a predetermined amount. A heating coil on the shaft is energizable by remote control for heating the shaft to a temperature range which transforms the shaft to its contracted length, whereby a latching shoulder thereof engages latching elements of the latching system and imposes a tensile preload on the structural joint. Provision is also made for manually adjusting the probe head on the shaft to allow for manual detachment of the structures or manual preloading of the structural joint.

NASA Safety Manual. Volume 3: System Safety

NASA Technical Reports Server (NTRS)

1970-01-01

This Volume 3 of the NASA Safety Manual sets forth the basic elements and techniques for managing a system safety program and the technical methods recommended for use in developing a risk evaluation program that is oriented to the identification of hazards in aerospace hardware systems and the development of residual risk management information for the program manager that is based on the hazards identified. The methods and techniques described in this volume are in consonance with the requirements set forth in NHB 1700.1 (VI), Chapter 3. This volume and future volumes of the NASA Safety Manual shall not be rewritten, reprinted, or reproduced in any manner. Installation implementing procedures, if necessary, shall be inserted as page supplements in accordance with the provisions of Appendix A. No portion of this volume or future volumes of the NASA Safety Manual shall be invoked in contracts.

Incubator weaning in preterm infants and associated practice variation.

PubMed

Schneiderman, R; Kirkby, S; Turenne, W; Greenspan, J

2009-08-01

To evaluate the relationship of weight of preterm infants when first placed into an open crib with days to full oral feedings, growth velocity and length of stay (LOS), and to identify unwarranted variation in incubator weaning after adjusting for severity indices. A retrospective study using the ParadigmHealth neonatal database from 2003 to 2006 reviewed incubator weaning to an open crib in appropriate-for-gestational-age (AGA) infants from 22 to weeks gestation. Primary outcome measurements included days to full oral (PO) feeding, weight gain from open crib to discharge and length of stay. Models were severity adjusted. To understand hospital practice variation, we also used a regression model to estimate the weight at open crib for the top 10 volume hospitals. In all 2908 infants met the inclusion criteria for the study. Their mean weight at open crib was 1850 g. On average every additional 100 g an infant weighed at the open crib was associated with increased time to full PO feeding by 0.8 days, decreased weight gained per day by 1 gram and increased LOS by 0.9 days. For the top 10 volume hospitals, severity variables alone accounted for 9% of the variation in weight at open crib, whereas the hospital in which the baby was treated accounted for an additional 19% of the variation. Even after controlling for severity, significant practice variation exists in weaning to an open crib, leading to potential delays in achieving full-volume oral feeds, decreased growth velocity and prolonged LOS.

Development of a membrane-based process for the treatment of oily waste waters. Final report, March 4, 1992--March 5, 1994

DOE Office of Scientific and Technical Information (OSTI.GOV)

McCray, S.B.

1994-05-25

This is a final report from Bend Research, Inc., (BRI) to the U.S. Department of Energy (DOE) for work performed under Contract No. DE-AC22-92MT92005, titled {open_quotes}Development of a Membrane-Based Process for the Treatment of Oily Waste Waters.{close_quotes} This report covers the period from March 4, 1992, to March 5, 1994. The overall goal of this program was to develop an economical oily-water treatment system based on reverse osmosis (RO). The RO system would be used to (1) reduce oil production costs by reducing the volume of waste water that must be disposed of, (2) form the basis of a genericmore » waste-water treatment system that can easily be integrated into oil-field operations, especially at production facilities that are small or in remote locations; and (3) produce water clean enough to meet existing and anticipated environmental regulations. The specific focus of this program was the development of a hollow-fiber membrane module capable of treating oily waste waters.« less

Voltage-Gated Ion Channels in Cancer Cell Proliferation

PubMed Central

Rao, Vidhya R.; Perez-Neut, Mathew; Kaja, Simon; Gentile, Saverio

2015-01-01

Changes of the electrical charges across the surface cell membrane are absolutely necessary to maintain cellular homeostasis in physiological as well as in pathological conditions. The opening of ion channels alter the charge distribution across the surface membrane as they allow the diffusion of ions such as K+, Ca++, Cl−, Na+. Traditionally, voltage-gated ion channels (VGIC) are known to play fundamental roles in controlling rapid bioelectrical signaling including action potential and/or contraction. However, several investigations have revealed that these classes of proteins can also contribute significantly to cell mitotic biochemical signaling, cell cycle progression, as well as cell volume regulation. All these functions are critically important for cancer cell proliferation. Interestingly, a variety of distinct VGICs are expressed in different cancer cell types, including metastasis but not in the tissues from which these tumors were generated. Given the increasing evidence suggesting that VGIC play a major role in cancer cell biology, in this review we discuss the role of distinct VGIC in cancer cell proliferation and possible therapeutic potential of VIGC pharmacological manipulation. PMID:26010603

Comparison of the effects of several potassium-channel openers on rat bladder and rat portal vein in vitro.

PubMed Central

Edwards, G.; Henshaw, M.; Miller, M.; Weston, A. H.

1991-01-01

1. The ability of several K-channel openers to inhibit KCl-induced contractions of rat bladder detrusor and spontaneous mechanical activity in rat portal vein was examined. 2. Lemakalim, pinacidil, Ro 31-6930, RP 49356, P1060 and S 0121 dose-dependently relaxed rat detrusor, precontracted with 20 mM KCl. With the exception of pinacidil, concentrations of these agents below 30 microM did not inhibit 80 mM KCl-included contractions. Pinacidil (10 microM) produced a small, but significant (P < 0.05) relaxation of 80 mM KCl-induced mechanical activity. Minoxidil sulphate and BRL 38226 produced some relaxation of 20 mM but not 80 mM KCl-induced contractions. 3. Glibenclamide (0.3-3 microM) antagonized the relaxant effects of lemakalim, pinacidil, Ro 31-6930, RP 49356, P1060 and S 0121 in a competitive manner (pA2 values 6.3-6.6). The effects of minoxidil sulphate and BRL 38226 were fully antagonized by 3 microM glibenclamide. 4. Lemakalim, pinacidil, S 0121, BRL 38226 and minoxidil sulphate were each approximately 8 times more potent as inhibitors of the spontaneous contractions of rat portal vein than KCl-induced contractions of the rat detrusor. Minoxidil sulphate was approximately 30 times more potent in the rat portal vein than in the bladder. This may indicate that either minoxidil sulphate is acting at different recognition sites in these two tissues, or that this compound has an additional mechanism of action in the portal vein. 5. With the exception of minoxidil sulphate, all the compounds tested stimulated 86Rb efflux and 42K efflux from preloaded rat detrusor strips.(ABSTRACT TRUNCATED AT 250 WORDS) PMID:1364839

Effect of number and position of intraocular lens haptics on anterior capsule contraction: a randomized, prospective trial.

PubMed

Choi, Mihyun; Lazo, Marjorie Z; Kang, Minji; Lee, Jeehye; Joo, Choun-Ki

2018-03-20

The present study aimed to evaluate the degree of anterior capsule contraction (capsulorhexis contraction) with three different single-piece, hydrophilic acrylic intraocular lenses (IOLs). Patients were prospectively randomized to be implanted with one of three types of IOLs during cataract surgery: the Ophtec Precizon (IOL A), the Lucid Korea Microflex (IOL B), and the Carl Zeiss Asphina (IOL C). One week, 2 weeks, and 6 months after surgery, the area of the anterior capsule opening was measured using digital retro-illumination images after dilation of the pupil. The data were then evaluated using POCOman software. The study included 236 eyes of 202 patients. The area of the anterior capsule opening reduced by 3.53 ± 3.31 mm (17.06% ± 15.99%) between 1 week and 2 months post-operatively in the IOL A group, by 0.62 ± 1.32 mm (2.87% ± 6.03%) in the IOL B group, and by 1.09 ± 1.53 mm (4.72% ± 6.10%) in the IOL C group. The IOL B group showed minimal anterior capsule contraction 2 months after surgery (p < 0.001). IOLs with a four-plate haptic design (IOL B) showed more anterior capsular stability than those with a two-loop plate haptic (IOL A) or two-plate haptic (IOL C) design. The number and position of haptics in a capsular bag may affect anterior capsule contraction. We assume that supporting the zonules evenly may play a role in anterior capsular stability. Current Controlled Trials ISRCTN76566080 , Retrospectively registered (Date of registration: 14 Feb 2018).

International ultraviolet explorer observatory operations

NASA Technical Reports Server (NTRS)

1986-01-01

This volume contains the Final Report for the International Ultraviolet Explorer (IUE) Observatory Operations contract, NAS5-28787. The report summarizes the activities of the IUE Observatory over the 13-month period from November 1985 through November 1986 and is arranged in sections according to the functions specified in the Statement of Work (SOW) of the contract. In order to preserve numerical correspondence between the technical SOW elements specified by the contract and the sections of this report, project management activities (SOW element 0.0.) are reported here in Section 7, following the reports of technical SOW elements 1.0 through 6.0. Routine activities have been summarized briefly whenever possible; statistical compilations, reports, and more lengthy supplementary material are contained in the Appendices.

Breathing of Graphite Particles in a Lithium-Ion Battery

NASA Astrophysics Data System (ADS)

Takata, Keiji; Okuda, Mitsuhiro; Yura, Nobuki; Tamura, Ryota

2012-04-01

We imaged changes in volume of graphite particles in a Li-ion battery due to the insertion and extraction of Li ions using scanning probe microscopy. When Li ions were extracted from the graphite particles, the particles were contracted, while expansion was induced in the interspaces between the particles. Variations of the images of volume changes depending on modulation frequencies clearly showed lithium intercalation. A linear relationship between the amplitudes of volume changes and the products of the diffusion elements and the reciprocals of the frequencies has been proven. Thus, the detected signals quantitatively well corresponded to the lithium ion movements.

Carbon Dioxide Removal and the futures market

NASA Astrophysics Data System (ADS)

Lockley, A.; Coffman, D.

2016-12-01

Futures contracts are exchange-traded financial instruments that enable parties to fix a price in advance, for performance on a contract at some later date. Forward contracts also entail future settlement, but they are traded over-the-counter between two independent parties. Both futures and forward contracts are commonly used in commodities trading, as producers seek financial security when planning production. We discuss the use of potential use of exchange-traded futures contracts in Carbon Dioxide Removal (CDR) markets. We conclude that they have one principal advantage (in that they give near-term price security to current polluters), and one principal disadvantage (in that a combination of high price volatility and high trade volume means contracts issued by the private sector may cause systemic economic risk). Accordingly, we note the potential for the development of futures markets in CDR, but urge great caution in the use of this approach. In particular, we consider the use of regulated markets: to ensure contracts are more reliable, and that moral hazard is minimised. Whilst regulation offers generally increased assurances, we identify major insufficiencies with this approach - finding it generally inadequate. In conclusion, we suggest that only governments can realistically support long-term CDR futures markets. We note existing long-term CDR plans by governments, and suggest the use of state-backed futures for supporting these assurances.

Incentive contracts for development projects

NASA Astrophysics Data System (ADS)

Finley, David T.; Smith, Byron; DeGroff, B.

2012-09-01

Finding a contract vehicle that balances the concerns of the customer and the contractor in a development project can be difficult. The customer wants a low price and an early delivery, with as few surprises as possible as the project progresses. The contractor wants sufficient cost and schedule to cover risk. Both want to clearly define what each party will provide. Many program offices do not want to award cost plus contracts because their funding sources will not allow it, their boards do not want an open ended commitment, and they feel like they lose financial control of the project. A fixed price incentive contract, with a mutually agreed upon target cost, provides the owner with visibility into the project and input into the execution of the project, encourages both parties to save costs, and stimulates a collaborative atmosphere by aligning the respective interests of customers and contractors.

Advanced spatiotemporal mapping methods give new insights into the coordination of contractile activity in the stomach of the rat.

PubMed

Lentle, R G; Reynolds, G W; Hulls, C M; Chambers, J P

2016-12-01

We used spatiotemporal mapping of strain rate to determine the direction of propagation and amplitudes of the longitudinal and circumferential components of antrocorporal (AC) contractions and fundal contractions in the rat stomach maintained ex vivo and containing a volume of fluid that was within its normal functional capacity. In the region of the greater curvature the longitudinal and circular components of AC contractions propagated synchronously at right angles to the arciform geometric axis of the stomach. However, the configuration of AC contractions was U shaped, neither the circular nor the longitudinal component of contractions being evident in the upper proximal corpus. Similarly, in the distal upper antrum of some preparations, circumferential components propagated more rapidly than longitudinal components. Ongoing "high-frequency, low-amplitude myogenic contractions" were identified in the upper proximal gastric corpus and on the anterior and posterior wall of the fundus. The amplitudes of these contractions were modulated in the occluded stomach by low-frequency pressure waves that occurred spontaneously. Hence the characteristics of phasic contractions vary regionally in the antrum and corpus and a previously undescribed high-frequency contractile component was identified in the proximal corpus and fundus, the latter being modulated in synchrony with cyclic variation in intrafundal pressure in the occluded fundus. Copyright © 2016 the American Physiological Society.

Non-price competition in NHS secondary care contracting: empirical results.

PubMed

Gray, Keith; Bailey, Mark F

2008-01-01

The purpose of this paper is, for English acute NHS hospitals, to investigate how they operate their governance systems in the area of secondary care contracting and identify the key determinants of relationship building within the contacting/commissioning of secondary care focusing upon non-price competitive behaviour. A survey instrument was designed and mailed to a sample of all acute NHS hospitals in England of whom 35 per cent responded. This survey was then analysed using logit techniques. The analysis suggests that: those NHS Trusts offering volume discounts, non-price competitive incentives or having a strong belief in performance being by "payment by results" criteria are significantly more likely to offer augmented services to secondary care purchasers over and above contractual minima; those NHS Trusts strongly believing in the importance of non-price factors (such as contract augmentation or quality) in the contracting process are more likely to offer customisation of generic services; and those NHS Trusts using cost-sharing agreements to realign contracts when negotiating contracts or who strongly believe in the importance of service augmentation in strengthening relationships, or that increased hospital efficiency is the most important aspect of recent NHS reform are more likely to utilise default measures to help realign contracts. This paper fills a gap in the area of non-price competition in English NHS acute secondary care contracting.

Expanded Guidance for NASA Systems Engineering. Volume 2: Crosscutting Topics, Special Topics, and Appendices

NASA Technical Reports Server (NTRS)

Hirshorn, Steven R.

2017-01-01

Historically, most successful NASA projects have depended on effectively blending project management, systems engineering, and technical expertise among NASA, contractors, and third parties. Underlying these successes are a variety of agreements (e.g., contract, memorandum of understanding, grant, cooperative agreement) between NASA organizations or between NASA and other Government agencies, Government organizations, companies, universities, research laboratories, and so on. To simplify the discussions, the term "contract" is used to encompass these agreements. This section focuses on the NASA systems engineering activities pertinent to awarding a contract, managing contract performance, and completing a contract. In particular, NASA systems engineering interfaces to the procurement process are covered, since the NASA engineering technical team plays a key role in the development and evaluation of contract documentation. Contractors and third parties perform activities that supplement (or substitute for) the NASA project technical team accomplishment of the NASA common systems engineering technical process activities and requirements outlined in this guide. Since contractors might be involved in any part of the systems engineering life cycle, the NASA project technical team needs to know how to prepare for, allocate or perform, and implement surveillance of technical activities that are allocated to contractors.

Carbon dioxide removal and the futures market

NASA Astrophysics Data System (ADS)

Coffman, D.'Maris; Lockley, Andrew

2017-01-01

Futures contracts are exchange-traded financial instruments that enable parties to fix a price in advance, for later performance on a contract. Forward contracts also entail future settlement, but they are traded directly between two parties. Futures and forwards are used in commodities trading, as producers seek financial security when planning production. We discuss the potential use of futures contracts in Carbon Dioxide Removal (CDR) markets; concluding that they have one principal advantage (near-term price security to current polluters), and one principal disadvantage (a combination of high price volatility and high trade volume means contracts issued by the private sector may cause systemic economic risk). Accordingly, we note the potential for the development of futures markets in CDR, but urge caution about the prospects for market failure. In particular, we consider the use of regulated markets: to ensure contracts are more reliable, and that moral hazard is minimised. While regulation offers increased assurances, we identify major insufficiencies with this approach—finding it generally inadequate. In conclusion, we suggest that only governments can realistically support long-term CDR futures markets. We note existing long-term CDR plans by governments, and suggest the use of state-backed futures for supporting these assurances.

Gene Therapy With Angiotensin-(1-9) Preserves Left Ventricular Systolic Function After Myocardial Infarction.

PubMed

Fattah, Caroline; Nather, Katrin; McCarroll, Charlotte S; Hortigon-Vinagre, Maria P; Zamora, Victor; Flores-Munoz, Monica; McArthur, Lisa; Zentilin, Lorena; Giacca, Mauro; Touyz, Rhian M; Smith, Godfrey L; Loughrey, Christopher M; Nicklin, Stuart A

2016-12-20

Angiotensin-(1-9) [Ang-(1-9)] is a novel peptide of the counter-regulatory axis of the renin-angiotensin-aldosterone system previously demonstrated to have therapeutic potential in hypertensive cardiomyopathy when administered via osmotic mini-pump. Here, we investigate whether gene transfer of Ang-(1-9) is cardioprotective in a murine model of myocardial infarction (MI). The authors evaluated effects of Ang-(1-9) gene therapy on myocardial structural and functional remodeling post-infarction. C57BL/6 mice underwent permanent left anterior descending coronary artery ligation and cardiac function was assessed using echocardiography for 8 weeks followed by a terminal measurement of left ventricular pressure volume loops. Ang-(1-9) was delivered by adeno-associated viral vector via single tail vein injection immediately following induction of MI. Direct effects of Ang-(1-9) on cardiomyocyte excitation/contraction coupling and cardiac contraction were evaluated in isolated mouse and human cardiomyocytes and in an ex vivo Langendorff-perfused whole-heart model. Gene delivery of Ang-(1-9) reduced sudden cardiac death post-MI. Pressure volume measurements revealed complete restoration of end-systolic pressure, ejection fraction, end-systolic volume, and the end-diastolic pressure volume relationship by Ang-(1-9) treatment. Stroke volume and cardiac output were significantly increased versus sham. Histological analysis revealed only mild effects on cardiac hypertrophy and fibrosis, but a significant increase in scar thickness. Direct assessment of Ang-(1-9) on isolated cardiomyocytes demonstrated a positive inotropic effect via increasing calcium transient amplitude and contractility. Ang-(1-9) increased contraction in the Langendorff model through a protein kinase A-dependent mechanism. Our novel findings showed that Ang-(1-9) gene therapy preserved left ventricular systolic function post-MI, restoring cardiac function. Furthermore, Ang-(1-9) directly affected cardiomyocyte calcium handling through a protein kinase A-dependent mechanism. These data emphasized Ang-(1-9) gene therapy as a potential new strategy in the context of MI. Copyright © 2016 The Authors. Published by Elsevier Inc. All rights reserved.

Water-vapor pressure control in a volume

NASA Technical Reports Server (NTRS)

Scialdone, J. J.

1978-01-01

The variation with time of the partial pressure of water in a volume that has openings to the outside environment and includes vapor sources was evaluated as a function of the purging flow and its vapor content. Experimental tests to estimate the diffusion of ambient humidity through openings and to validate calculated results were included. The purging flows required to produce and maintain a certain humidity in shipping containers, storage rooms, and clean rooms can be estimated with the relationship developed here. These purging flows are necessary to prevent the contamination, degradation, and other effects of water vapor on the systems inside these volumes.

13 CFR 121.1004 - What time limits apply to size protests?

Code of Federal Regulations, 2010 CFR

2010-01-01

..., Sundays, and legal holidays, after bid or proposal opening. (2) Negotiated procurement. A protest must be... paragraph (e), for purposes of the SBIR program the contracting officer and SBA may file a protest in...

13 CFR 121.1004 - What time limits apply to size protests?

Code of Federal Regulations, 2011 CFR

2011-01-01

..., Sundays, and legal holidays, after bid or proposal opening. (2) Negotiated procurement. A protest must be... paragraph (e), for purposes of the SBIR program the contracting officer and SBA may file a protest in...

13 CFR 121.1004 - What time limits apply to size protests?

Code of Federal Regulations, 2012 CFR

2012-01-01

..., Sundays, and legal holidays, after bid or proposal opening. (2) Negotiated procurement. A protest must be... paragraph (e), for purposes of the SBIR program the contracting officer and SBA may file a protest in...

Application of adaptive antenna techniques to future commercial satellite communication

NASA Technical Reports Server (NTRS)

Ersoy, L.; Lee, E. A.; Matthews, E. W.

1987-01-01

The purpose of this contract was to identify the application of adaptive antenna technique in future operational commercial satellite communication systems and to quantify potential benefits. The contract consisted of two major subtasks. Task 1, Assessment of Future Commercial Satellite System Requirements, was generally referred to as the Adaptive section. Task 2 dealt with Pointing Error Compensation Study for a Multiple Scanning/Fixed Spot Beam Reflector Antenna System and was referred to as the reconfigurable system. Each of these tasks was further sub-divided into smaller subtasks. It should also be noted that the reconfigurable system is usually defined as an open-loop system while the adaptive system is a closed-loop system. The differences between the open- and closed-loop systems were defined. Both the adaptive and reconfigurable systems were explained and the potential applications of such systems were presented in the context of commercial communication satellite systems.

Application of adaptive antenna techniques to future commercial satellite communications. Executive summary

NASA Technical Reports Server (NTRS)

Ersoy, L.; Lee, E. A.; Matthews, E. W.

1987-01-01

The purpose of this contract was to identify the application of adaptive antenna technique in future operational commercial satellite communication systems and to quantify potential benefits. The contract consisted of two major subtasks. Task 1, Assessment of Future Commercial Satellite System Requirements, was generally referred to as the Adaptive section. Task 2 dealt with Pointing Error Compensation Study for a Multiple Scanning/Fixed Spot Beam Reflector Antenna System and was referred to as the reconfigurable system. Each of these tasks was further subdivided into smaller subtasks. It should also be noted that the reconfigurable system is usually defined as an open-loop system while the adaptive system is a closed-loop system. The differences between the open- and closed-loop systems were defined. Both the adaptive and reconfigurable systems were explained and the potential applications of such systems were presented in the context of commercial communication satellite systems.

Agreements in Virtual Organizations

NASA Astrophysics Data System (ADS)

Pankowska, Malgorzata

This chapter is an attempt to explain the important impact that contract theory delivers with respect to the concept of virtual organization. The author believes that not enough research has been conducted in order to transfer theoretical foundations for networking to the phenomena of virtual organizations and open autonomic computing environment to ensure the controllability and management of them. The main research problem of this chapter is to explain the significance of agreements for virtual organizations governance. The first part of this chapter comprises explanations of differences among virtual machines and virtual organizations for further descriptions of the significance of the first ones to the development of the second. Next, the virtual organization development tendencies are presented and problems of IT governance in highly distributed organizational environment are discussed. The last part of this chapter covers analysis of contracts and agreements management for governance in open computing environments.

Initial Northwest Power Act Power Sales Contracts : Final Environmental Impact Statement. Volume 2, Appendices A--L.

DOE Office of Scientific and Technical Information (OSTI.GOV)

United States. Bonneville Power Administration.

1992-01-01

This report consists of appendices A-L of the final environmental impact statement for the Bonneville Power Administration. The appendices provide information on the following: Ninth circuit Court opinion in Forelaws on Board v. Johnson; guide to Northwest Power act contracts; guide to hydro operations; glossary; affected environment supporting documentation; environmental impacts of generic resource types; information on models used; technical information on analysis; public involvement activities; bibliography; Pacific Northwest Electric Power Planning and Conservation Act; and biological assessment. (CBS)

Secular cooling of Earth as a source of intraplate stress

NASA Technical Reports Server (NTRS)

Solomon, Sean C.

1987-01-01

The once popular idea that changes in planetary volume play an important role in terrestrial orogeny and tectonics was generally discarded with the acceptance of plate tectonics. It is nonetheless likely that the Earth has been steadily cooling over the past 3-4 billion years, and the global contraction that accompanied such cooling would have led to a secular decrease in the radius of curvature of the plates. The implications of this global cooling and contraction are explored here for the intraplate stress field and the evolution of continental plates.

The Influence of the Competition in Contracting Act on the Volume of Competitive Prime Contract Awards for Major Hard Goods and Non-Major Hard Goods Purchased by the Department of Defense

DTIC Science & Technology

1988-11-16

parts was less than for sole source acquired spare parts see, Alan E. Olsen ; James E. Cunningham; and Donald J. Wilkins, "A Cost-Benefit Analysis of...Washington, D.C. Logistc Management-Institute, MUTT- I 339 I Zusman, Morris; Asher, Norman; Wetzler, Elliot; Bennett, Debbie; Gustaves, Selmer ; Higgins...Acquisition." Masters Thesis, Naval Postgraduate School, 1984. Olsen , Alan E.; Cunningham, James E.; and Wilkins, Donald J. "A Cost-Benefit Analysis of

Mapping DICOM to OpenDocument format

NASA Astrophysics Data System (ADS)

Yu, Cong; Yao, Zhihong

2009-02-01

In order to enhance the readability, extensibility and sharing of DICOM files, we have introduced XML into DICOM file system (SPIE Volume 5748)[1] and the multilayer tree structure into DICOM (SPIE Volume 6145)[2]. In this paper, we proposed mapping DICOM to ODF(OpenDocument Format), for it is also based on XML. As a result, the new format realizes the separation of content(including text content and image) and display style. Meanwhile, since OpenDocument files take the format of a ZIP compressed archive, the new kind of DICOM files can benefit from ZIP's lossless compression to reduce file size. Moreover, this open format can also guarantee long-term access to data without legal or technical barriers, making medical images accessible to various fields.

Agreement and reliability of pelvic floor measurements during contraction using three-dimensional pelvic floor ultrasound and virtual reality.

PubMed

Speksnijder, L; Rousian, M; Steegers, E A P; Van Der Spek, P J; Koning, A H J; Steensma, A B

2012-07-01

Virtual reality is a novel method of visualizing ultrasound data with the perception of depth and offers possibilities for measuring non-planar structures. The levator ani hiatus has both convex and concave aspects. The aim of this study was to compare levator ani hiatus volume measurements obtained with conventional three-dimensional (3D) ultrasound and with a virtual reality measurement technique and to establish their reliability and agreement. 100 symptomatic patients visiting a tertiary pelvic floor clinic with a normal intact levator ani muscle diagnosed on translabial ultrasound were selected. Datasets were analyzed using a rendered volume with a slice thickness of 1.5 cm at the level of minimal hiatal dimensions during contraction. The levator area (in cm(2)) was measured and multiplied by 1.5 to get the levator ani hiatus volume in conventional 3D ultrasound (in cm(3)). Levator ani hiatus volume measurements were then measured semi-automatically in virtual reality (cm(3) ) using a segmentation algorithm. An intra- and interobserver analysis of reliability and agreement was performed in 20 randomly chosen patients. The mean difference between levator ani hiatus volume measurements performed using conventional 3D ultrasound and virtual reality was 0.10 (95% CI, - 0.15 to 0.35) cm(3). The intraclass correlation coefficient (ICC) comparing conventional 3D ultrasound with virtual reality measurements was > 0.96. Intra- and interobserver ICCs for conventional 3D ultrasound measurements were > 0.94 and for virtual reality measurements were > 0.97, indicating good reliability for both. Levator ani hiatus volume measurements performed using virtual reality were reliable and the results were similar to those obtained with conventional 3D ultrasonography. Copyright © 2012 ISUOG. Published by John Wiley & Sons, Ltd.

Assessment of Right Atrium Function in Patients With Systemic Lupus Erythematosus With Different Pulmonary Artery Systolic Pressures by 2-Dimensional Speckle-Tracking Echocardiography.

PubMed

Sun, Lihua; Wang, Ying; Dong, Yu; Song, Shengda; Luo, Runlan; Li, Guangsen

2018-02-26

To assess right atrium (RA) function of patients with systemic lupus erythematosus (SLE) and pulmonary artery hypertension (PAH) by 2-dimensional speckle-tracking echocardiography. Thirty matched healthy adults were selected as group A. Then, 102 patients with SLE were divided into 3 groups according to the severity of PAH. Group B included 37 patients without PAH (pulmonary artery [PA] systolic pressure ≤ 30 mm Hg); group C included 34 patients with PAH (PA systolic pressure of 30-50 mm Hg); and group D included 31 patients with PAH (PA systolic pressure ≥ 50 mm Hg). Parameters evaluated included RA maximum volume, minimum volume, preatrial contraction volume, passive ejection fraction (EF), and active EF. The global peak longitudinal systolic strain rate and early and late diastolic strain rates of the RA were obtained by 2-dimensional speckle-tracking echocardiography. No significant differences were found in all parameters between groups B and A (P > .05). The RA maximum volume, minimum volume, preatrial contraction volume, active EF, and late diastolic strain rate in groups C and D were significantly increased compared with those in groups A and B, and the parameters in group D were significantly higher than those in group C (P < .05). Although the RA passive EF, early diastolic strain rate, and systolic strain rate in groups C and D were significantly decreased compared with those in groups A and B, those in group D were significantly lower than those in group C (P < .05). Two-dimensional speckle-tracking echocardiography could effectively assess RA function in patients with SLE who have different severities of PAH. © 2018 by the American Institute of Ultrasound in Medicine.

NASA safety manual. Volume 9: Fire protection

NASA Technical Reports Server (NTRS)

1985-01-01

Requirements are identified and guidelines are provided for implementing a comprehensive fire protection program. These requirements and guidelines are applicable to NASA headquarters and field installations. Portions also can be applied to NASA contractor operations within the scope of the contract.

A study of emissions from passenger cars in six cities. Volume B. Final report

DOE Office of Scientific and Technical Information (OSTI.GOV)

Not Available

1979-01-01

This is the second of two volumes presenting results from a series of exhaust emission and fuel economy tests performed on a representative sample of vehicles in six U.S. cities. Data presented in the following sections are generated in appendix form as part of a contract with the EPA to perform work for the FY 77 Passenger Car Emission Factor Program. Volume B includes the balance of individual vehicle data derived from the Two Speed Idle and Federal Three Mode tests. It also includes the results of Vehicle Driveability Evaluations, Maladjustment and Disablement Inspections, tire inspections and a listing ofmore » comparative mileage data. Information presented in Volume B should not be interpreted without the benefit of additional descriptive data presented in Volume A as both volumes comprise the results of a single work effort and are not intended to be considered separately.« less

26 CFR 20.2031-0 - Table of contents.

Code of Federal Regulations, 2011 CFR

2011-04-01

.... § 20.2031-5Valuation of cash on hand or on deposit. § 20.2031-6Valuation of household and personal... contracts; valuation of shares in an open-end investment company. § 20.2031-9Valuation of other property...

Bid opening report : Federal-aid highway construction contracts : first six months 1998

DOT National Transportation Integrated Search

1999-07-01

This document presents human factors guidelines for designers, owners operators, and planners involved in the development and operation of traffic management centers. Dimensions of the work environment affecting operator and system performance are ad...

Bid opening report : Federal-aid highway construction contracts : calendar year 1997

DOT National Transportation Integrated Search

1999-08-01

This summary report describes a May 1998 transportation technology scanning tour of four European countries. The tour was co-sponsored by the Federal Highway Administration (FHWA), the American Association of State Highway and Transportation Official...

Probing the nanostructure of polymers via cryogenic Positron Annihilation Lifetime Spectroscopy (PALS)

NASA Astrophysics Data System (ADS)

Bolan, B. A.; Soles, C. L.; Hristov, H. A.; Gidley, D. W.; Yee, A. F.

1996-03-01

A new method is proposed for the evaluation of the hole volume in amorphous polymers based upon PALS data measured over a temperature of 110 to 480 K. Extrapolation of the "open hole" volume to 0 K allows its separation into that attributed to the segmental motions of the polymer chains (dynamic) and that due to inefficient packing (static). The dynamic hole volume is correlated to thermodynamic volume/density fluctuations and its temperature dependencies are in good agreement with SAXS data. Several thermosetting epoxy materials are also studied over a similar temperature range with the "open hole" volume being separated into its dynamic and static components. How these two components affect diffusional properties of these systems is examined in detail. It is also shown that the o-Ps can localize in a nearly 100material (PET), we therefore conclude that PALS measures more than the "free volume" necessary for segmental motion. Work supported by the Air Force Office of Scientific Research (AFOSR) grant # F49620-95-1-0037.

CrossTalk: The Journal of Defense Software Engineering. Volume 24, Number 6. November/December 2011

DTIC Science & Technology

2011-11-01

Software Development.” Software Quality Professional Journal, American Society for Quality (ASQ), (March 2010) 4-14. 3. Nair, Gopalakrishnan T.R...Inspection Performance Metric”. Software Quality Professional Journal, American Society for Quality (ASQ), Volume 13, Issue 2, (March 2011) 14-26...the discovery process and are marketed by compa- nies such as Black Duck Software, OpenLogic, Palamida, and Protecode, among others.7 A number of open

Higher Education through Open and Distance Learning. World Review of Distance Education and Open Learning, Volume 1. A Commonwealth of Learning Series.

ERIC Educational Resources Information Center

Harry, Keith, Ed.

This book reports on the expansion of open and distance learning during the past decade, examining ways in which open and distance learning for higher education has responded to the needs of the new society, and summarizing the lessons of recent practice for policymakers and educators. After an introductory chapter, "Open and Distance…

Ejaculatory process and related semen characteristics.

PubMed

Bravo, P W; Moscoso, R; Alarcon, V; Ordoñez, C

2002-01-01

South American camelids are dribble ejaculators, and urethral contractions occur throughout copulation, which may last 25 min. The urethral contractions and their association with semen characteristics during copulation were determined in llamas and alpacas. A transrectal probe was held in the rectum of the male while copulating an artificial vagina, which was accessed underneath the dummy through a hole. The semen-collecting tube was changed every 5 min. Semen characteristics, color, volume, consistency, motility, concentration, and percentage of live sperm were determined at 5-min intervals. Urethral contractions were evenly distributed during copulation: 40 in alpacas and 63 in llamas (p < .05), with a general range of 11 to 132. Semen color was milky in 63%, and translucent in 36.5% for alpacas; and creamy (9.9%), milky (47%), and translucent (42%) for llamas. The mean volume of ejaculate was 0.3, 0.4, 0.6, 0.7, 0.6, 0.8, 0.3, and 3.0 mL for 5, 10, 15, 20, 25, and 30 min, respectively. Semen consistency was variable: viscous (65%) and semiviscous (34%) in alpacas; and viscous (57%) and semiviscous (42%) in llamas. Spermatic motility varied between 60 and 80% for the llama, and 40 and 80% for the alpaca. Spermatic concentration varied between 60 and 188 x 10(3)/mm3 in llamas, and 30 and 170 x 10(3)/mm3 in alpacas. Percentage of live sperm varied the least: 81 to 90% in llamas and 65 to 90% in alpacas. The ejaculate of llamas and alpacas is not fractionated, urethral contractions are evenly distributed, during copulation, and semen characteristics are present throughout the copulatory period.

Serum creatinine and albumin decline predict the contraction of nosocomial aspiration pneumonia in patients undergoing hemodialysis.

PubMed

Minakuchi, Hitoshi; Wakino, Shu; Hayashi, Koichi; Inamoto, Hajime; Itoh, Hiroshi

2014-08-01

Aspiration pneumonia (AP) is prevalent in older adults and the hemodialysis (HD) population has been getting older. Therefore, it is speculated that increasing number of HD patients would suffer from AP. However, the clinical aspects of AP in HD patients have not been elucidated. Consecutive HD patients with nosocomial AP hospitalized in our university hospital from April 2007 to December 2008 were recruited. Their clinical characteristics, risk factors for contraction, and the fatality of AP and treatment options were described. Nineteen out of 356 hospitalized HD patients had AP and 8 out of 19 AP patients died, indicating the incidence rate and fatality rate were 5.34% and 42.1%, respectively. Multiple regression analysis revealed that the risk factors for contracting AP included age, body mass index, serum creatinine levels (Cre) and the monthly decline rate of Cre. It also revealed that serum albumin (Alb) and basal total cholesterol levels, the decline rate of Alb and Cre levels, and the duration of AP were independent risk factors for fatality. Survivors were most often treated with tube feeding. Both contraction rate and fatality of nosocomial AP were high among HD patients. Both the malnutrition as well as the decline rate for nutrition and muscle volume indicated by falls in Alb and Cre, respectively, had clinical relevance in AP. Maintaining nutritional state by tube feeding and muscle volume seems to be the mainstay for the prevention and the treatment of AP in HD patients. © 2013 The Authors. Therapeutic Apheresis and Dialysis © 2013 International Society for Apheresis.

Advanced transportation system studies technical area 3: Alternate propulsion subsystem concepts, volume 2

NASA Technical Reports Server (NTRS)

Levak, Daniel

1993-01-01

The Alternate Propulsion Subsystem Concepts contract had five tasks defined for the first year. The tasks were: F-1A Restart Study, J-2S Restart Study, Propulsion Database Development, Space Shuttle Main Engine (SSME) Upper Stage Use, and CER's for Liquid Propellant Rocket Engines. The detailed study results, with the data to support the conclusions from various analyses, are being reported as a series of five separate Final Task Reports. Consequently, this volume only reports the required programmatic information concerning Computer Aided Design Documentation, and New Technology Reports. A detailed Executive Summary, covering all the tasks, is also available as Volume 1.

Synthesis and biological activity of novel 1,3-benzoxazine derivatives as K+ channel openers.

PubMed

Yamamoto, S; Hashiguchi, S; Miki, S; Igata, Y; Watanabe, T; Shiraishi, M

1996-04-01

A new series of 1,3-benzoxazine derivatives with a 2-pyridine 1-oxide group at C4 was designed to explore novel K+ channel openers. Synthesis was carried out by using a palladium(0)-catalyzed carbon-carbon bond formation reaction of imino-triflates with organozinc reagents and via a new one-pot 1,3-benzoxazine skeleton formation reaction of benzoylpyridines. The compounds were tested for vasorelaxant activity in tetraethylammonium chloride (TEA) and BaCl2-induced and high KCl-induced contraction of rat aorta to identify potential K+ channel openers, and also for oral hypotensive effects in spontaneously hypertensive rats. An electron-withdrawing group with the proper shape at C6 and a methyl or halogeno group at C7 of the 1,3-benzoxazine nucleus were required for the development of optimal vasorelaxant and hypotensive activity. In particular, 2-(6-bromo-7-chloro-2,2-dimethyl-2H-1,3-benzoxazin-4-yl)pyridine 1-oxide (71) showed more potent vasorelaxant activity (EC50 = 0.14 microM) against TEA and BaCl2-induced contraction and longer-lasting hypotensive effects than cromakalim (1).

Tracking state deployments of commercial vehicle information systems and networks : 1998 Washington State report

DOT National Transportation Integrated Search

1999-12-01

Volume III of the Logical Architecture contract deliverable documents the Data Dictionary. This formatted version of the Teamwork model data dictionary is mechanically produced from the Teamwork CDIF (Case Data Interchange Format) output file. It is ...

48 CFR 5452.249 - Allocation.

Code of Federal Regulations, 2010 CFR

2010-10-01

... Section 5452.249 Federal Acquisition Regulations System DEFENSE LOGISTICS AGENCY, DEPARTMENT OF DEFENSE... Fuel Supply Center is authorized to use the following clause in domestic and overseas petroleum... Defense that the Defense Fuel Supply Center be provided contract volumes exceeding the pro rata amount of...

48 CFR 5452.249 - Allocation.

Code of Federal Regulations, 2014 CFR

2014-10-01

... Section 5452.249 Federal Acquisition Regulations System DEFENSE LOGISTICS AGENCY, DEPARTMENT OF DEFENSE... Fuel Supply Center is authorized to use the following clause in domestic and overseas petroleum... Defense that the Defense Fuel Supply Center be provided contract volumes exceeding the pro rata amount of...

48 CFR 5452.249 - Allocation.

Code of Federal Regulations, 2013 CFR

2013-10-01

... Section 5452.249 Federal Acquisition Regulations System DEFENSE LOGISTICS AGENCY, DEPARTMENT OF DEFENSE... Fuel Supply Center is authorized to use the following clause in domestic and overseas petroleum... Defense that the Defense Fuel Supply Center be provided contract volumes exceeding the pro rata amount of...

48 CFR 5452.249 - Allocation.

Code of Federal Regulations, 2011 CFR

2011-10-01

... Section 5452.249 Federal Acquisition Regulations System DEFENSE LOGISTICS AGENCY, DEPARTMENT OF DEFENSE... Fuel Supply Center is authorized to use the following clause in domestic and overseas petroleum... Defense that the Defense Fuel Supply Center be provided contract volumes exceeding the pro rata amount of...

48 CFR 5452.249 - Allocation.

Code of Federal Regulations, 2012 CFR

2012-10-01

... Section 5452.249 Federal Acquisition Regulations System DEFENSE LOGISTICS AGENCY, DEPARTMENT OF DEFENSE... Fuel Supply Center is authorized to use the following clause in domestic and overseas petroleum... Defense that the Defense Fuel Supply Center be provided contract volumes exceeding the pro rata amount of...

IVHS Countermeasures For Rear-End Collisions, Task 1 Volume I: Summary, Interim Report

DOT National Transportation Integrated Search

1994-02-01

THE ATTACHED REPORT IS FROM THE NHTSA SPONSORED PROGRAM, "IVHS COUNTERMEASURES FOR REAR-END COLLISIONS," CONTRACT #DTNH22-93-C-07326. THE PROGRAM'S PRIMARY OBJECTIVE IS TO DEVELOP PRACTICAL PERFORMANCE GUIDELINES OR SPECIFICATIONS FOR REAR-END COLLIS...

Court procedures for identifying problem drinkers. Volume 2, Supplemental readings

DOT National Transportation Integrated Search

1971-06-01

HSRI, under Contract FH-11-7615 with the National Highway Traffic Safety Administration (NHTSA), developed, during 1970 and 1971, a set of procedures for identifying problem drinkers. They were intended for use in a court setting, such as a pre-sente...

Court procedures for identifying problem drinkers. Volume 1, Manual

DOT National Transportation Integrated Search

1971-06-01

HSRI, under Contract FH-11-7615 with the National Highway Traffic Safety Administration (NHTSA), developed, during 1970 and 1971, a set of procedures for identifying problem drinkers. They were intended for use in a court setting, such as a pre-sente...

Locomotive cab design development. volume 2 : operator's manual - Interim Report

DOT National Transportation Integrated Search

1976-10-01

Locomotive Cab 913 designed as a result of Contract DOT-TSC- 913 has been built as a hard mock-up. This Operator's Manual is to familiarize the user with the mock-up. Normal and emergency procedures and cab facilities are described.

Six Strategies for Chemical Waste Minimization in Laboratories.

ERIC Educational Resources Information Center

Matteson, Gary C.; Hadley, Cheri R.

1991-01-01

Guidelines are offered to research administrators for reducing the volume of hazardous laboratory waste. Suggestions include a chemical location inventory, a chemical reuse facility, progressive contracts with chemical suppliers, internal or external chemical recycling mechanisms, a "chemical conservation" campaign, and laboratory fees for…

Court procedures for identifying problem drinkers. Volume 3, Scoring keys

DOT National Transportation Integrated Search

1971-06-01

HSRI, under Contract FH-11-7615 with the National Highway Traffic Safety Administration (NHTSA), developed, during 1970 and 1971, a set of procedures for identifying problem drinkers. They were intended for use in court setting, such as a pre-sentenc...

Comprehensive Monitoring Program: Air Quality Data Assessment Report for FY90. Volume 2. Version 3.1

DTIC Science & Technology

1991-09-01

91311R01 If VERSION 3.10) VOLUME II Comm 2ND COPY COMPREHENSIVE MONITORING PROGRAM Contract Number DAAAI5-87-0095 AIR QUALITY DATA ASSESSMENT REPORT...MONITORING PROGRAM. FINAL AIR QUALITY DATA ASSESSMENT REPORT FOR FY90, VERSION 3.1 NONE 6. AUTHOR(S) 7. PERFORMING ORGANIZATION NAME(S) AND ADDRES.S(S) 8...RELEASE; DISTRIBUTION IS UNLIMITED 13. ABSTRACT (Maximum 200 words) THE OBJECTIVE OF THIS CMP IS TO: VERIFY AND EVALUATE POTENTIAL AIR QUALITY HEALTH

DCAA Contract Audit Manual. Volume 2, Chapters 12 - 15, Appendixes A - I. Volume 2

DTIC Science & Technology

1995-01-01

facilities for cafe - curred by the contractor. terias, dining rooms, canteens, lunch (FACs 84-15, 7 Apr 86) wagons, vending machines, living accom...Voluntary Accounting WGI 5990.23 CCH Change CAS-WG 79-24-Allocation of Business Unit G&A Expenses WGI 5990.24 CCH CAS-WG 81-25-State Income/ Franchise ...Recommendation (FPRR) CAM 9-1202. 2 FRAME Describing the Sampling Frame CAM B- 209 FRANCHISE CAS-WG 81-25-State Income/ Franchise Tax WGI 5990.25 CCH

Portable Low Volume Therapy for Severe Blood Loss

DTIC Science & Technology

2016-08-01

loss . 8 24-hour survival showed no statistical differences (p>0.05) between BHB/M (mean survival 21.0 ± 2.74 hrs) and 4 M BHB, 4.3 mM melatonin...in Figure 6 were compared 24 hours and 10 days after 60% blood loss . Pairwise comparisons are summarized in Table 3. No treatment differences were...Award Number: W81XWH-11-1-0409 TITLE: Portable Low-Volume Therapy for Severe Blood Loss PRINCIPAL INVESTIGATOR: Matthew T. Andrews CONTRACTING

Toward a Mathematical Theory of Counterterrorism (Proteus USA, Volume 1, Issue 2, December 2007)

DTIC Science & Technology

2007-12-01

Toward a MaTheMaTical Theory of counTerTerrorisM The Proteus Monograph Series Volume 1, Issue 2 December 2007 Report Documentation Page Form...COVERED 00-00-2007 to 00-00-2007 4. TITLE AND SUBTITLE Toward a Mathematical Theory of Counterterrorism 5a. CONTRACT NUMBER 5b. GRANT NUMBER 5c...Army War College,Center for Strategic Leadership ,650 Wright Avenue,Carlisle,PA,17013-5049 8. PERFORMING ORGANIZATION REPORT NUMBER 9. SPONSORING

Remote lift fan study program, volume 4

NASA Technical Reports Server (NTRS)

1973-01-01

A study program to select and conduct preliminary design of advanced technology lift fan systems to meet low noise goals of future V/STOL transport aircraft is discussed. This volume contains results of additional studies conducted to support the main preliminary design effort done under the Remote Lift Fan Study Program (Contract NAS3-14406) and a companion effort, the Integral Lift Fan Study (NAS3-14404). These results cover engine emission study, a review of existing engines for research aircraft application and support data for aircraft studies.