Sample records for wag354g zyxel prestige

  1. Prestige in Interest Activity Assessment

    ERIC Educational Resources Information Center

    Sodano, Sandro M.; Tracey, Terence J. G.

    2008-01-01

    Prestige has been demonstrated to be a component in interest assessment [Tracey, T. J. G. (1997). The structure of interests and self-efficacy expectations: An expanded examination of the spherical model of interests. "Journal of Counseling Psychology", 44, 32-43; Tracey, T. J. G. (2002). Personal Globe Inventory: Measurement of the spherical…

  2. [Reverse learning in WAG/Rij rats with depression-like behavior].

    PubMed

    Malyshev, A V; Zakharov, A M; Sarkisova, K Iu; Dubynin, V A

    2012-01-01

    Learning and reverse learning in a complex maze, behavior in the open field test, novelty-suppressed feeding test, and forced swimming test were studies in WAG/Rij and Wistar rats. As compared with Wistar rats, WAG/Rij rats more slowly learned the spatial task, more slowly performed in the learning and reverse learning tasks, and made more errors in the complex maze (18% of WAG/Rij rats didn't reach learning criterion). Moreover, WAG/Rij rats exhibited reduced grooming reactions in the open field test, longer latency of approaching to food in the novel open field, reduced amount of food consumed in the home cage in the novelty-suppressed feeding test, and increased immobility time in the forced swimming test. The results suggest cognitive impaiment in WAG/Rij rats with depression-like behavior.

  3. Behavioural responses of dogs to asymmetrical tail wagging of a robotic dog replica.

    PubMed

    Artelle, K A; Dumoulin, L K; Reimchen, T E

    2011-03-01

    Recent evidence suggests that bilateral asymmetry in the amplitude of tail wagging of domestic dogs (Canis familiaris) is associated with approach (right wag) versus withdrawal (left wag) motivation and may be the by-product of hemispheric dominance. We consider whether such asymmetry in motion of the tail, a crucial appendage in intra-specific communication in all canids, provides visual information to a conspecific leading to differential behaviour. To evaluate this, we experimentally investigated the approach behaviour of free-ranging dogs to the asymmetric tail wagging of a life-size robotic dog replica. Our data, involving 452 separate interactions, showed a significantly greater proportion of dogs approaching the model continuously without stopping when the tail wagged to the left, compared with a right wag, which was more likely to yield stops. While the results indicate that laterality of a wagging tail provides behavioural information to conspecifics, the responses are not readily integrated into the predicted behaviour based on hemispheric dominance.

  4. The Prestige Treadmill: Connections between Prestige and Revenue in Higher Education

    ERIC Educational Resources Information Center

    Sanford, Thomas

    2011-01-01

    This study examines the relationship between prestige and institutional funding profiles. Specifically, it analyses the relationship between increases in institutional prestige and an institution's dependency on traditional revenue sources, defined as tuition, fees, and state appropriations. Research and theory suggest that increases in prestige…

  5. Magma wagging and whirling in volcanic conduits

    NASA Astrophysics Data System (ADS)

    Liao, Yang; Bercovici, David; Jellinek, Mark

    2018-02-01

    Seismic tremor characterized by 0.5-7 Hz ground oscillations commonly occur before and during eruptions at silicic volcanoes with widely ranging vent geometries and edifice structures. The ubiquitous characteristics of this tremor imply that its causes are potentially common to silicic volcanoes. Here we revisit and extend to three dimensions the magma-wagging model for tremor (Jellinek and Bercovici, 2011; Bercovici et al., 2013), wherein a stiff magma column rising in a vertical conduit oscillates against a surrounding foamy annulus of bubbly magma, giving rise to tremor. While prior studies were restricted to two-dimensional lateral oscillations, here we explore three-dimensional motion and additional modes of oscillations. In the absence of viscous damping, the magma column undergoes 'whirling' motion: the center of each horizontal section of the column traces an elliptical trajectory. In the presence of viscous effect we identify new 'coiling' and 'uncoiling' column bending shapes with relatively higher and comparable rates of dissipation to the original two-dimensional magma wagging model. We also calculate the seismic P-wave response of the crustal material around the volcanic conduit to the new whirling motions and propose seismic diagnostics for different wagging patterns using the time-lag between seismic stations. We test our model by analyzing pre-eruptive seismic data from the 2009 eruption of Redoubt Volcano. In addition to suggesting that the occurrence of elliptical whirling motion more than 1 week before the eruption, our analysis of seismic time-lags also implies that the 2009 eruption was accompanied by qualitative changes in the magma wagging behavior including fluctuations in eccentricity and a reversal in the direction of elliptical whirling motion when the eruption was immediately impending.

  6. Image and Prestige Planning

    ERIC Educational Resources Information Center

    Ager, Dennis

    2005-01-01

    The aim of this paper is to clarify some notions about image and prestige planning. Starting from the Welsh example of language policy aiming to revitalise a language in danger of further decreasing in number of speakers and in centrality to Welsh life, definitions of four related terms are explored: image, status, prestige and identity. Paired…

  7. Proepileptic patterns in EEG of WAG/Rij rats

    NASA Astrophysics Data System (ADS)

    Grubov, Vadim V.; Sitnikova, Evgenia Yu.; Nedaivozov, Vladimir O.; Koronovskii, Alexey A.

    2018-04-01

    In this paper we study specific oscillatory patterns on EEG signals of WAG/Rij rats. These patterns are known as proepileptic because they occur in time period during the development of absence-epilepsy before fully-formed epileptic seizures. In the paper we analyze EEG signals of WAG/Rij rats with continuous wavelet transform and empirical mode decomposition in order to find particular features of epileptic spike-wave discharges and nonepileptic sleep spindles. Then we introduce proepileptic activity as patterns that combine features of epileptic and non-epileptic activity. We analyze proepileptic activity in order to specify its features and time-frequency structure.

  8. Association of the TYMS 3G/3G genotype with poor response and GGH 354GG genotype with the bone marrow toxicity of the methotrexate in RA patients.

    PubMed

    Jekic, Biljana; Lukovic, Ljiljana; Bunjevacki, Vera; Milic, Vera; Novakovic, Ivana; Damnjanovic, Tatjana; Milasin, Jelena; Popovic, Branka; Maksimovic, Nela; Damjanov, Nemanja; Radunovic, Goran; Kovacevic, Ljiljana; Krajinovic, Maja

    2013-03-01

    Gamma-glutamyl hydrolase (GGH), cyclin D1 (CCND1) and thymidylate synthase (TS) genes encode enzymes that are involved in methotrexate (MTX) action. In a group of 184 RA patients treated with MTX, we have investigated whether selected polymorphisms in these genes modulate MTX efficacy and/or have impact on adverse drug effects (ADEs). The efficacy of the MTX therapy has been estimated using the disease activity score in 28 joints (DAS28-ESR) based on EULAR criteria and relative DAS28 values (rDAS28). All adverse drug events were recorded. Patients were genotyped for selected polymorphisms of the GGH (-354 G > T and 452 C > T), CCND1 (870 A > G) and TYMS (variable number of tandem repeats, VNTR, and G to C substitution of triple repeat, 3R allele) gene. Association studies have been performed between obtained genotypes and the efficacy and toxicity of MTX. According to the EULAR response criteria, 146 RA patients (79.3 %) were classified as responders (good/moderate response) and 38 (20.7 %) as non-responders (poor response). Higher frequency of the TYMS 3 G/3 G genotype has been found among non-responders as compared to individuals with remaining genotypes (p = 0.02). ADEs were recorded in 53 patients. Among those patients eight experienced bone marrow toxicity, all of them carried GGH -354GG genotype (p = 0.003). No other significant association were observed. The 3 G/3 G genotype of the TYMS gene may indicate predisposition of poor response to MTX and GG genotype of GGH -354 T > G polymorphism may have high predictive value for myelosuppression in RA patients.

  9. A Prestige Study of Business Education Subjects

    ERIC Educational Resources Information Center

    Faidley, Ray A.; DeMuth, Audry S.

    1977-01-01

    High and low prestige factors perceived by business education teachers, chapter officers of Delta Pi Epsilon, in various business education subjects showed close agreement between high school and college teachers on the prestige attached to teaching certain subjects. Implications for curriculum and teacher education are given. (MF)

  10. Gender Differences in Enrollment in High Prestige Academic College Majors.

    ERIC Educational Resources Information Center

    Nelson, Eileen S.; Dixon, Cynthia

    1997-01-01

    A study examined the percentages of freshmen and seniors enrolled in high-prestige majors at James Madison University (Virginia), using a prestige ranking for 30 majors based on student body ratings. Contrary to expectation, there was not a higher percentage of male than female seniors enrolled in high-prestige majors. (Author/MSE)

  11. 9 CFR 354.14 - Authority to waive provisions of § 354.12.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ...§ 354.12. 354.14 Section 354.14 Animals and Animal Products FOOD SAFETY AND INSPECTION SERVICE, DEPARTMENT OF AGRICULTURE AGENCY ORGANIZATION AND TERMINOLOGY; MANDATORY MEAT AND POULTRY PRODUCTS INSPECTION AND VOLUNTARY INSPECTION AND CERTIFICATION VOLUNTARY INSPECTION OF RABBITS AND EDIBLE PRODUCTS THEREOF...

  12. Seeing left- or right-asymmetric tail wagging produces different emotional responses in dogs.

    PubMed

    Siniscalchi, Marcello; Lusito, Rita; Vallortigara, Giorgio; Quaranta, Angelo

    2013-11-18

    Left-right asymmetries in behavior associated with asymmetries in the brain are widespread in the animal kingdom, and the hypothesis has been put forward that they may be linked to animals' social behavior. Dogs show asymmetric tail-wagging responses to different emotive stimuli-the outcome of different activation of left and right brain structures controlling tail movements to the right and left side of the body. A crucial question, however, is whether or not dogs detect this asymmetry. Here we report that dogs looking at moving video images of conspecifics exhibiting prevalent left- or right-asymmetric tail wagging showed higher cardiac activity and higher scores of anxious behavior when observing left- rather than right-biased tail wagging. The finding that dogs are sensitive to the asymmetric tail expressions of other dogs supports the hypothesis of a link between brain asymmetry and social behavior and may prove useful to canine animal welfare theory and practice. Copyright © 2013 Elsevier Ltd. All rights reserved.

  13. Optimization of CO2 Storage in Saline Aquifers Using Water-Alternating Gas (WAG) Scheme - Case Study for Utsira Formation

    NASA Astrophysics Data System (ADS)

    Agarwal, R. K.; Zhang, Z.; Zhu, C.

    2013-12-01

    For optimization of CO2 storage and reduced CO2 plume migration in saline aquifers, a genetic algorithm (GA) based optimizer has been developed which is combined with the DOE multi-phase flow and heat transfer numerical simulation code TOUGH2. Designated as GA-TOUGH2, this combined solver/optimizer has been verified by performing optimization studies on a number of model problems and comparing the results with brute-force optimization which requires a large number of simulations. Using GA-TOUGH2, an innovative reservoir engineering technique known as water-alternating-gas (WAG) injection has been investigated to determine the optimal WAG operation for enhanced CO2 storage capacity. The topmost layer (layer # 9) of Utsira formation at Sleipner Project, Norway is considered as a case study. A cylindrical domain, which possesses identical characteristics of the detailed 3D Utsira Layer #9 model except for the absence of 3D topography, was used. Topographical details are known to be important in determining the CO2 migration at Sleipner, and are considered in our companion model for history match of the CO2 plume migration at Sleipner. However, simplification on topography here, without compromising accuracy, is necessary to analyze the effectiveness of WAG operation on CO2 migration without incurring excessive computational cost. Selected WAG operation then can be simulated with full topography details later. We consider a cylindrical domain with thickness of 35 m with horizontal flat caprock. All hydrogeological properties are retained from the detailed 3D Utsira Layer #9 model, the most important being the horizontal-to-vertical permeability ratio of 10. Constant Gas Injection (CGI) operation with nine-year average CO2 injection rate of 2.7 kg/s is considered as the baseline case for comparison. The 30-day, 15-day, and 5-day WAG cycle durations are considered for the WAG optimization design. Our computations show that for the simplified Utsira Layer #9 model, the

  14. Seismic Tremors and Three-Dimensional Magma Wagging

    NASA Astrophysics Data System (ADS)

    Liao, Y.; Bercovici, D.

    2015-12-01

    Seismic tremor is a feature shared by many silicic volcanoes and is a precursor of volcanic eruption. Many of the characteristics of tremors, including their frequency band from 0.5 Hz to 7 Hz, are common for volcanoes with very different geophysical and geochemical properties. The ubiquitous characteristics of tremor imply that it results from some generation mechanism that is common to all volcanoes, instead of being unique to each volcano. Here we present new analysis on the magma-wagging mechanism that has been proposed to generate tremor. The model is based on the suggestion given by previous work (Jellinek & Bercovici 2011; Bercovici et.al. 2013) that the magma column is surrounded by a compressible, bubble-rich foam annulus while rising inside the volcanic conduit, and that the lateral oscillation of the magma inside the annulus causes observable tremor. Unlike the previous two-dimensional wagging model where the displacement of the magma column is restricted to one vertical plane, the three-dimensional model we employ allows the magma column to bend in different directions and has angular motion as well. Our preliminary results show that, without damping from viscous deformation of the magma column, the system retains angular momentum and develops elliptical motion (i.e., the horizontal displacement traces an ellipse). In this ''inviscid'' limit, the magma column can also develop instabilities with higher frequencies than what is found in the original two-dimensional model. Lateral motion can also be out of phase for various depths in the magma column leading to a coiled wagging motion. For the viscous-magma model, we predict a similar damping rate for the uncoiled magma column as in the two-dimensional model, and faster damping for the coiled magma column. The higher damping thus requires the existence of a forcing mechanism to sustain the oscillation, for example the gas-driven Bernoulli effect proposed by Bercovici et al (2013). Finally, using our new 3

  15. The evolution of leader-follower reciprocity: the theory of service-for-prestige.

    PubMed

    Price, Michael E; Van Vugt, Mark

    2014-01-01

    We describe the service-for-prestige theory of leadership, which proposes that voluntary leader-follower relations evolved in humans via a process of reciprocal exchange that generated adaptive benefits for both leaders and followers. We propose that although leader-follower relations first emerged in the human lineage to solve problems related to information sharing and social coordination, they ultimately evolved into exchange relationships whereby followers could compensate leaders for services which would otherwise have been prohibitively costly for leaders to provide. In this exchange, leaders incur costs to provide followers with public goods, and in return, followers incur costs to provide leaders with prestige (and associated fitness benefits). Because whole groups of followers tend to gain from leader-provided public goods, and because prestige is costly for followers to produce, the provisioning of prestige to leaders requires solutions to the "free rider" problem of disrespectful followers (who benefit from leader services without sharing the costs of producing prestige). Thus service-for-prestige makes the unique prediction that disrespectful followers of beneficial leaders will be targeted by other followers for punitive sentiment and/or social exclusion. Leader-follower relations should be more reciprocal and mutually beneficial when leaders and followers have more equal social bargaining power. However, as leaders gain more relative power, and their high status becomes less dependent on their willingness to pay the costs of benefitting followers, service-for-prestige predicts that leader-follower relations will become based more on leaders' ability to dominate and exploit rather than benefit followers. We review evidential support for a set of predictions made by service-for-prestige, and discuss how service-for-prestige relates to social neuroscience research on leadership.

  16. Effect of Childhood Victimization on Occupational Prestige and Income Trajectories

    PubMed Central

    Fernandez, Cristina A.; Christ, Sharon L.; LeBlanc, William G.; Arheart, Kristopher L.; Dietz, Noella A.; McCollister, Kathyrn E.; Fleming, Lora E.; Muntaner, Carles; Muennig, Peter; Lee, David J.

    2015-01-01

    Background Violence toward children (childhood victimization) is a major public health problem, with long-term consequences on economic well-being. The purpose of this study was to determine whether childhood victimization affects occupational prestige and income in young adulthood. We hypothesized that young adults who experienced more childhood victimizations would have less prestigious jobs and lower incomes relative to those with no victimization history. We also explored the pathways in which childhood victimization mediates the relationships between background variables, such as parent’s educational impact on the socioeconomic transition into adulthood. Methods A nationally representative sample of 8,901 young adults aged 18–28 surveyed between 1999–2009 from the National Longitudinal Survey of Youth 1997 (NLSY) were analyzed. Covariate-adjusted multivariate linear regression and path models were used to estimate the effects of victimization and covariates on income and prestige levels and on income and prestige trajectories. After each participant turned 18, their annual 2002 Census job code was assigned a yearly prestige score based on the 1989 General Social Survey, and their annual income was calculated via self-reports. Occupational prestige and annual income are time-varying variables measured from 1999–2009. Victimization effects were tested for moderation by sex, race, and ethnicity in the multivariate models. Results Approximately half of our sample reported at least one instance of childhood victimization before the age of 18. Major findings include 1) childhood victimization resulted in slower income and prestige growth over time, and 2) mediation analyses suggested that this slower prestige and earnings arose because victims did not get the same amount of education as non-victims. Conclusions Results indicated that the consequences of victimization negatively affected economic success throughout young adulthood, primarily by slowing the

  17. The evolution of leader–follower reciprocity: the theory of service-for-prestige

    PubMed Central

    Price, Michael E.; Van Vugt, Mark

    2014-01-01

    We describe the service-for-prestige theory of leadership, which proposes that voluntary leader–follower relations evolved in humans via a process of reciprocal exchange that generated adaptive benefits for both leaders and followers. We propose that although leader–follower relations first emerged in the human lineage to solve problems related to information sharing and social coordination, they ultimately evolved into exchange relationships whereby followers could compensate leaders for services which would otherwise have been prohibitively costly for leaders to provide. In this exchange, leaders incur costs to provide followers with public goods, and in return, followers incur costs to provide leaders with prestige (and associated fitness benefits). Because whole groups of followers tend to gain from leader-provided public goods, and because prestige is costly for followers to produce, the provisioning of prestige to leaders requires solutions to the “free rider” problem of disrespectful followers (who benefit from leader services without sharing the costs of producing prestige). Thus service-for-prestige makes the unique prediction that disrespectful followers of beneficial leaders will be targeted by other followers for punitive sentiment and/or social exclusion. Leader–follower relations should be more reciprocal and mutually beneficial when leaders and followers have more equal social bargaining power. However, as leaders gain more relative power, and their high status becomes less dependent on their willingness to pay the costs of benefitting followers, service-for-prestige predicts that leader–follower relations will become based more on leaders’ ability to dominate and exploit rather than benefit followers. We review evidential support for a set of predictions made by service-for-prestige, and discuss how service-for-prestige relates to social neuroscience research on leadership. PMID:24926244

  18. Avenues to prestige among adolescents in public and religiously affiliated high schools.

    PubMed

    Suitor, J Jill; Powers, Rebecca S; Brown, Rachel

    2004-01-01

    We used data from 1,733 college students to explore whether adolescents' avenues to prestige differ in public and private high schools. Students attending seven large universities during the 1997--98 academic year provided information on the ways in which adolescents in their high schools had gained prestige with peers. The analyses revealed no differences by high school type for girls, with the exception of greater emphasis on clothes in public schools as compared with private schools. For boys, the differences were more pronounced. Boys who attended private schools were less likely than those who attended public schools to accrue prestige through clothes and car ownership and more likely to gain prestige through general sociability and having a good reputation. However, boys who attended private schools were more likely to gain prestige through being the class clown. Taken together, the findings show few differences between avenues to prestige for girls in private and public high schools, and differences for boys that are not uniformly in the direction that parents and private school advocates would predict or desire.

  19. 19 CFR 354.10 - Discovery.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 19 Customs Duties 3 2014-04-01 2014-04-01 false Discovery. 354.10 Section 354.10 Customs Duties... ANTIDUMPING OR COUNTERVAILING DUTY ADMINISTRATIVE PROTECTIVE ORDER § 354.10 Discovery. (a) Voluntary discovery. All parties are encouraged to engage in voluntary discovery procedures regarding any matter, not...

  20. 19 CFR 354.10 - Discovery.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 19 Customs Duties 3 2011-04-01 2011-04-01 false Discovery. 354.10 Section 354.10 Customs Duties... ANTIDUMPING OR COUNTERVAILING DUTY ADMINISTRATIVE PROTECTIVE ORDER § 354.10 Discovery. (a) Voluntary discovery. All parties are encouraged to engage in voluntary discovery procedures regarding any matter, not...

  1. 19 CFR 354.10 - Discovery.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 19 Customs Duties 3 2013-04-01 2013-04-01 false Discovery. 354.10 Section 354.10 Customs Duties... ANTIDUMPING OR COUNTERVAILING DUTY ADMINISTRATIVE PROTECTIVE ORDER § 354.10 Discovery. (a) Voluntary discovery. All parties are encouraged to engage in voluntary discovery procedures regarding any matter, not...

  2. 19 CFR 354.10 - Discovery.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 19 Customs Duties 3 2012-04-01 2012-04-01 false Discovery. 354.10 Section 354.10 Customs Duties... ANTIDUMPING OR COUNTERVAILING DUTY ADMINISTRATIVE PROTECTIVE ORDER § 354.10 Discovery. (a) Voluntary discovery. All parties are encouraged to engage in voluntary discovery procedures regarding any matter, not...

  3. 9 CFR 354.131 - Decomposition.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 9 Animals and Animal Products 2 2010-01-01 2010-01-01 false Decomposition. 354.131 Section 354.131 Animals and Animal Products FOOD SAFETY AND INSPECTION SERVICE, DEPARTMENT OF AGRICULTURE AGENCY... Carcasses and Parts § 354.131 Decomposition. Carcasses of rabbits deleteriously affected by post-mortem...

  4. 9 CFR 354.131 - Decomposition.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 9 Animals and Animal Products 2 2014-01-01 2014-01-01 false Decomposition. 354.131 Section 354.131 Animals and Animal Products FOOD SAFETY AND INSPECTION SERVICE, DEPARTMENT OF AGRICULTURE AGENCY... Carcasses and Parts § 354.131 Decomposition. Carcasses of rabbits deleteriously affected by post-mortem...

  5. 9 CFR 354.131 - Decomposition.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 9 Animals and Animal Products 2 2013-01-01 2013-01-01 false Decomposition. 354.131 Section 354.131 Animals and Animal Products FOOD SAFETY AND INSPECTION SERVICE, DEPARTMENT OF AGRICULTURE AGENCY... Carcasses and Parts § 354.131 Decomposition. Carcasses of rabbits deleteriously affected by post-mortem...

  6. 9 CFR 354.131 - Decomposition.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 9 Animals and Animal Products 2 2012-01-01 2012-01-01 false Decomposition. 354.131 Section 354.131 Animals and Animal Products FOOD SAFETY AND INSPECTION SERVICE, DEPARTMENT OF AGRICULTURE AGENCY... Carcasses and Parts § 354.131 Decomposition. Carcasses of rabbits deleteriously affected by post-mortem...

  7. 19 CFR 354.10 - Discovery.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 19 Customs Duties 3 2010-04-01 2010-04-01 false Discovery. 354.10 Section 354.10 Customs Duties... ANTIDUMPING OR COUNTERVAILING DUTY ADMINISTRATIVE PROTECTIVE ORDER § 354.10 Discovery. (a) Voluntary discovery. All parties are encouraged to engage in voluntary discovery procedures regarding any matter, not...

  8. WAG 2 remedial investigation and site investigation site-specific work plan/health and safety checklist for the sediment transport modeling task

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Holt, V.L.; Baron, L.A.

    1994-05-01

    This site-specific Work Plan/Health and Safety Checklist (WP/HSC) is a supplement to the general health and safety plan (HASP) for Waste Area Grouping (WAG) 2 remedial investigation and site investigation (WAG 2 RI&SI) activities [Health and Safety Plan for the Remedial Investigation and Site Investigation of Waste Area Grouping 2 at the Oak Ridge National Laboratory, Oak Ridge, Tennessee (ORNL/ER-169)] and provides specific details and requirements for the WAG 2 RI&SI Sediment Transport Modeling Task. This WP/HSC identifies specific site operations, site hazards, and any recommendations by Oak Ridge National Laboratory (ORNL) health and safety organizations [i.e., Industrial Hygiene (IH),more » Health Physics (HP), and/or Industrial Safety] that would contribute to the safe completion of the WAG 2 RI&SI. Together, the general HASP for the WAG 2 RI&SI (ORNL/ER-169) and the completed site-specific WP/HSC meet the health and safety planning requirements specified by 29 CFR 1910.120 and the ORNL Hazardous Waste Operations and Emergency Response (HAZWOPER) Program Manual. In addition to the health and safety information provided in the general HASP for the WAG 2 RI&SI, details concerning the site-specific task are elaborated in this site-specific WP/HSC, and both documents, as well as all pertinent procedures referenced therein, will be reviewed by all field personnel prior to beginning operations.« less

  9. 9 CFR 354.245 - Vermin.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 9 Animals and Animal Products 2 2010-01-01 2010-01-01 false Vermin. 354.245 Section 354.245 Animals and Animal Products FOOD SAFETY AND INSPECTION SERVICE, DEPARTMENT OF AGRICULTURE AGENCY... Precautions Against Contamination of Products § 354.245 Vermin. Every practicable precaution shall be taken to...

  10. 9 CFR 354.240 - General.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 9 Animals and Animal Products 2 2010-01-01 2010-01-01 false General. 354.240 Section 354.240 Animals and Animal Products FOOD SAFETY AND INSPECTION SERVICE, DEPARTMENT OF AGRICULTURE AGENCY... Precautions Against Contamination of Products § 354.240 General. The premises shall be kept free from refuse...

  11. [Comparative analysis of the maternal motivation expression in WAG/Rij and Wistar rats in the place preference and open field tests].

    PubMed

    Dobriakova, Iu V; Tanaeva, K K; Dubynin, V A; Sarkisova, K Iu

    2014-01-01

    Maternal behavior in females of WAG/Rij and Wistar rats was compared in the place preference test from 2 to 8 days after delivery, as well as in the open field test from 4 to 6 days after delivery. In females of WAG/Rij rats compared with females of Wistar rats weaker expression of maternal motivation has been revealed in both tests: they spend less time in the compartment associated with pups. Moreover, in females of WAG/Rij rats, number of approaches to pups, number of pup-carryings and time spent with pups (time of contacts) were less than in females of Wistar rats. Reduced maternal motivation in females of WAG/Rij rats in the place preference test persisted in repeated testing, while in the open field test it was detected only in the first testing, indicating higher reliability of the place preference test for revealing inter-strain differences in the expression of maternal motivation. It is supposed that weaker expression of maternal behavior and preference is due to hypo-function of the mesolimbic dopaminergic bran system in WAG/Rij rats as a genetic model of depression associated with absence epilepsy.

  12. 9 CFR 354.3 - Administration.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 9 Animals and Animal Products 2 2010-01-01 2010-01-01 false Administration. 354.3 Section 354.3... CERTIFICATION VOLUNTARY INSPECTION OF RABBITS AND EDIBLE PRODUCTS THEREOF Administration § 354.3 Administration... prescribed in the regulations in this part and as the Secretary may require in the administration of the...

  13. 19 CFR 354.12 - Hearing.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 19 Customs Duties 3 2010-04-01 2010-04-01 false Hearing. 354.12 Section 354.12 Customs Duties... ANTIDUMPING OR COUNTERVAILING DUTY ADMINISTRATIVE PROTECTIVE ORDER § 354.12 Hearing. (a) Scheduling of hearing. The presiding official will schedule the hearing at a reasonable time, date, and place, which will be...

  14. 9 CFR 354.13 - Supervision.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 9 Animals and Animal Products 2 2014-01-01 2014-01-01 false Supervision. 354.13 Section 354.13... CERTIFICATION VOLUNTARY INSPECTION OF RABBITS AND EDIBLE PRODUCTS THEREOF Basis of Service § 354.13 Supervision. All inspection service shall be subject to supervision at all times by the station supervisor, circuit...

  15. 9 CFR 354.13 - Supervision.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 9 Animals and Animal Products 2 2011-01-01 2011-01-01 false Supervision. 354.13 Section 354.13... CERTIFICATION VOLUNTARY INSPECTION OF RABBITS AND EDIBLE PRODUCTS THEREOF Basis of Service § 354.13 Supervision. All inspection service shall be subject to supervision at all times by the station supervisor, circuit...

  16. 9 CFR 354.13 - Supervision.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 9 Animals and Animal Products 2 2012-01-01 2012-01-01 false Supervision. 354.13 Section 354.13... CERTIFICATION VOLUNTARY INSPECTION OF RABBITS AND EDIBLE PRODUCTS THEREOF Basis of Service § 354.13 Supervision. All inspection service shall be subject to supervision at all times by the station supervisor, circuit...

  17. 9 CFR 354.13 - Supervision.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 9 Animals and Animal Products 2 2010-01-01 2010-01-01 false Supervision. 354.13 Section 354.13... CERTIFICATION VOLUNTARY INSPECTION OF RABBITS AND EDIBLE PRODUCTS THEREOF Basis of Service § 354.13 Supervision. All inspection service shall be subject to supervision at all times by the station supervisor, circuit...

  18. 9 CFR 354.13 - Supervision.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 9 Animals and Animal Products 2 2013-01-01 2013-01-01 false Supervision. 354.13 Section 354.13... CERTIFICATION VOLUNTARY INSPECTION OF RABBITS AND EDIBLE PRODUCTS THEREOF Basis of Service § 354.13 Supervision. All inspection service shall be subject to supervision at all times by the station supervisor, circuit...

  19. 9 CFR 354.3 - Administration.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 9 Animals and Animal Products 2 2012-01-01 2012-01-01 false Administration. 354.3 Section 354.3... CERTIFICATION VOLUNTARY INSPECTION OF RABBITS AND EDIBLE PRODUCTS THEREOF Administration § 354.3 Administration... prescribed in the regulations in this part and as the Secretary may require in the administration of the...

  20. 9 CFR 354.3 - Administration.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 9 Animals and Animal Products 2 2014-01-01 2014-01-01 false Administration. 354.3 Section 354.3... CERTIFICATION VOLUNTARY INSPECTION OF RABBITS AND EDIBLE PRODUCTS THEREOF Administration § 354.3 Administration... prescribed in the regulations in this part and as the Secretary may require in the administration of the...

  1. 9 CFR 354.129 - General.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 9 Animals and Animal Products 2 2010-01-01 2010-01-01 false General. 354.129 Section 354.129 Animals and Animal Products FOOD SAFETY AND INSPECTION SERVICE, DEPARTMENT OF AGRICULTURE AGENCY... Carcasses and Parts § 354.129 General. The carcasses or parts of carcasses of all rabbits inspected at an...

  2. 9 CFR 354.3 - Administration.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 9 Animals and Animal Products 2 2011-01-01 2011-01-01 false Administration. 354.3 Section 354.3... CERTIFICATION VOLUNTARY INSPECTION OF RABBITS AND EDIBLE PRODUCTS THEREOF Administration § 354.3 Administration... prescribed in the regulations in this part and as the Secretary may require in the administration of the...

  3. 9 CFR 354.72 - Packaging.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 9 Animals and Animal Products 2 2010-01-01 2010-01-01 false Packaging. 354.72 Section 354.72... CERTIFICATION VOLUNTARY INSPECTION OF RABBITS AND EDIBLE PRODUCTS THEREOF Supervision of Marking and Packaging § 354.72 Packaging. No container which bears or may bear any official identification or any abbreviation...

  4. 9 CFR 354.220 - Buildings.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 9 Animals and Animal Products 2 2010-01-01 2010-01-01 false Buildings. 354.220 Section 354.220... CERTIFICATION VOLUNTARY INSPECTION OF RABBITS AND EDIBLE PRODUCTS THEREOF Buildings and Plant Facilities § 354.220 Buildings. The buildings shall be of sound construction and kept in good repair, and shall be of...

  5. Potentiation of mGlu5 receptors with the novel enhancer, VU0360172, reduces spontaneous absence seizures in WAG/Rij rats

    PubMed Central

    D’Amore, V.; Santolini, I.; van Rijn, C.M.; Biagioni, F.; Molinaro, G.; Prete, A.; Conn, P.J.; Lindsley, C.W.; Zhou, Y.; Vinson, P.N.; Rodriguez, A.L.; Jones, C.K.; Stauffer, S.R.; Nicoletti, F.; van Luijtelaar, G.; Ngomba, R.T.

    2013-01-01

    Absence epilepsy is generated by the cortico-thalamo-cortical network, which undergoes a finely tuned regulation by metabotropic glutamate (mGlu) receptors. We have shown previously that potentiation of mGlu1 receptors reduces spontaneous occurring spike and wave discharges (SWDs) in the WAG/Rij rat model of absence epilepsy, whereas activation of mGlu2/3 and mGlu4 receptors produces the opposite effect. Here, we have extended the study to mGlu5 receptors, which are known to be highly expressed within the cortico-thalamo-cortical network. We used presymptomatic and symptomatic WAG/Rij rats and aged-matched ACI rats. WAG/Rij rats showed a reduction in the mGlu5 receptor protein levels and in the mGlu5-receptor mediated stimulation of polyphosphoinositide hydrolysis in the ventrobasal thalamus, whereas the expression of mGlu5 receptors was increased in the somatosensory cortex. Interestingly, these changes preceded the onset of the epileptic phenotype, being already visible in pre-symptomatic WAG/Rij rats. SWDs in symptomatic WAG/Rij rats were not influenced by pharmacological blockade of mGlu5 receptors with MTEP (10 or 30 mg/kg, i.p.), but were significantly decreased by mGlu5 receptor potentiation with the novel enhancer, VU0360172 (3 or 10 mg/kg, s.c.), without affecting motor behaviour. The effect of VU0360172 was prevented by co-treatment with MTEP. These findings suggest that changes in mGlu5 receptors might lie at the core of the absence-seizure prone phenotype of WAG/Rij rats, and that mGlu5 receptor enhancers are potential candidates to the treatment of absence epilepsy. PMID:22705340

  6. A pyschoanalysis of The Prestige.

    PubMed

    Bhatnagar, Gagan

    2009-06-01

    The portrayal of psychopathy in certain films goes beyond the diagnostic formulations. The duality within the human behaviour of action and thought raises questions about the way individuals behave. Using The Prestige (2006) as an example, the roles of obsessions and sacrifice are utilized to demonstrate relationships.

  7. Rapamycin and WYE-354 suppress human gallbladder cancer xenografts in mice

    PubMed Central

    Stein, Stefan; Kunkel, Hana; García, Patricia; Bizama, Carolina; Espinoza, Jaime A.; Riquelme, Ismael; Nervi, Bruno; Araya, Juan C.

    2015-01-01

    Gallbladder cancer (GBC) is a highly malignant tumor characterized by a poor response to chemotherapy and radiotherapy. We evaluated the in vitro and in vivo antitumor efficacy of mTOR inhibitors, rapamycin and WYE-354. In vitro assays showed WYE-354 significantly reduced cell viability, migration and invasion and phospho-P70S6K expression in GBC cells. Mice harboring subcutaneous gallbladder tumors, treated with WYE-354 or rapamycin, exhibited a significant reduction in tumor mass. A short-term treatment with a higher dose of WYE-354 decreased the tumor size by 68.6% and 52.4%, in mice harboring G-415 or TGBC-2TKB tumors, respectively, compared to the control group. By contrast, treatment with a prolonged-low-dose regime of rapamycin almost abrogated tumor growth, exhibiting 92.7% and 97.1% reduction in tumor size, respectively, compared to control mice. These results were accompanied by a greater decrease in the phosphorylation status of P70S6K and a lower cell proliferation Ki67 index, compared to WYE-354 treated mice, suggesting a more effective mTOR pathway inhibition. These findings provide a proof of concept for the use of rapamycin or WYE-354 as potentially good candidates to be studied in clinical trials in GBC patients. PMID:26397134

  8. [Nurses' professional prestige: estimate of magnitudes and expanded categories].

    PubMed

    Sousa, F A; da Silva, J A

    2001-01-01

    The prestige of professionals such as social workers, biologists, dentists, nurses, engineers, pharmacists, physicists, physical therapists, speech-language pathologists, physicians, psychologists, chemists and sociologists was scaled by the psychophysical methods of estimation of magnitudes and expanded categories. Results showed that: 1) when we increase the limited amplitude of categories, this method has the same characteristics as those of the estimation of magnitudes. 2) the relationship between the estimations of magnitudes and estimations of expanded categories is a power function with an exponent that is not significantly different from 1.0. These data enabled the following conclusions: 1--The nursing profession is in the seventh or eighth position regarding the prestige of the 13 professions whereas physicians are in the first position in the scale obtained by the used methods; 2--the orders resulting from the methods produce positions of prestige that highly agree for the different professions.

  9. 7 CFR 1250.354 - Confidential treatment.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 7 Agriculture 10 2010-01-01 2010-01-01 false Confidential treatment. 1250.354 Section 1250.354 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (MARKETING... Research and Promotion Order Reports, Books, and Records § 1250.354 Confidential treatment. (a) All...

  10. Targeted Victimization: Exploring Linear and Curvilinear Associations Between Social Network Prestige and Victimization.

    PubMed

    Andrews, Naomi C Z; Hanish, Laura D; Updegraff, Kimberly A; Martin, Carol Lynn; Santos, Carlos E

    2016-09-01

    Are early adolescent victims of peer-directed aggression youth who hold prominent positions in the social hierarchy or those who are socially marginalized? The present study tackles this question by testing for linear and curvilinear relationships between social network prestige and physical and relational forms of peer victimization for boys and girls. Participants were 952 middle schoolers (age range = 10-14 years; 49.9 % girls; 44 % Latino). Participants nominated victims and friends; friendship nominations were used to calculate social network prestige. Both hypotheses received support, with variation by gender. Girls high in social network prestige were highly victimized. For boys, those both high and low in social network prestige were highly victimized, whereas those at mid-levels of social network prestige were low in victimization. The findings are discussed in relation to a social dominance model of peer-directed aggression, and the practical implications are discussed in relation to protecting youth who are frequent targets of peer victimization.

  11. [Behavior and functional state of the dopaminergic brain system in pups of depressive WAG/Rij rats].

    PubMed

    Malyshev, A V; Razumkina, E V; Rogozinskaia, É Ia; Sarkisova, K Iu; Dybynin, V A

    2014-01-01

    In the present work, it has been studied for the first time behavior and functional state of the dopaminergic brain system in pups of "depressive" WAG/Rij rats. Offspring of "depressive" WAG/Rij rats at age of 6-16 days compared with offspring of "normal" (non-depressed) outbred rats of the same age exhibited reduced rate of pshychomotor development, lower body weight, attenuation in integration of coordinated reflexes and vestibular function (greater latency of righting reflex, abnormal negative geotaxis), hyper-reactivity to tactile stimulation, reduced motivation to contact with mother (reduced infant-mother attachment). Differences in a nest seeking response induced by olfactory stimuli (olfactory discrimination test) and in locomotor activity (tests "gait reflex" and "small open field") have not been revealed. Acute injection of the antagonist of D2-like dopamine receptors clebopride 20 min before testing aggravated mother-oriented behavior in 15-days-old pups of both "depressive" and "non-depressive" rats. However this effect was greater in pups of "depressive" WAG/Rij rats compared with pups of "normal" rats that may indicate reduced functional activity of the dopaminergic brain system in offspring of "depressive" rats. It is proposed that reduced attachment behavior in pups of "depressive" WAG/Rij rats might be a consequence of maternal depression and associated with it reduced maternal care. Moreover, reduced attachment behavior in pups of "depressive" rats might be an early precursor (a marker) of depressive-like pathology which become apparent later in life (approximately at age of 3 months).

  12. 46 CFR 183.354 - Battery installations.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 46 Shipping 7 2010-10-01 2010-10-01 false Battery installations. 183.354 Section 183.354 Shipping...) ELECTRICAL INSTALLATION Power Sources and Distribution Systems § 183.354 Battery installations. (a) Large batteries. Each large battery installation must be located in a locker, room or enclosed box solely...

  13. 46 CFR 183.354 - Battery installations.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 46 Shipping 7 2012-10-01 2012-10-01 false Battery installations. 183.354 Section 183.354 Shipping...) ELECTRICAL INSTALLATION Power Sources and Distribution Systems § 183.354 Battery installations. (a) Large batteries. Each large battery installation must be located in a locker, room or enclosed box solely...

  14. 46 CFR 183.354 - Battery installations.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 46 Shipping 7 2013-10-01 2013-10-01 false Battery installations. 183.354 Section 183.354 Shipping...) ELECTRICAL INSTALLATION Power Sources and Distribution Systems § 183.354 Battery installations. (a) Large batteries. Each large battery installation must be located in a locker, room or enclosed box solely...

  15. 46 CFR 183.354 - Battery installations.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 46 Shipping 7 2011-10-01 2011-10-01 false Battery installations. 183.354 Section 183.354 Shipping...) ELECTRICAL INSTALLATION Power Sources and Distribution Systems § 183.354 Battery installations. (a) Large batteries. Each large battery installation must be located in a locker, room or enclosed box solely...

  16. 46 CFR 183.354 - Battery installations.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 46 Shipping 7 2014-10-01 2014-10-01 false Battery installations. 183.354 Section 183.354 Shipping...) ELECTRICAL INSTALLATION Power Sources and Distribution Systems § 183.354 Battery installations. (a) Large batteries. Each large battery installation must be located in a locker, room or enclosed box solely...

  17. Adult learners in a novel environment use prestige-biased social learning.

    PubMed

    Atkisson, Curtis; O'Brien, Michael J; Mesoudi, Alex

    2012-08-13

    Social learning (learning from others) is evolutionarily adaptive under a wide range of conditions and is a long-standing area of interest across the social and biological sciences. One social-learning mechanism derived from cultural evolutionary theory is prestige bias, which allows a learner in a novel environment to quickly and inexpensively gather information as to the potentially best teachers, thus maximizing his or her chances of acquiring adaptive behavior. Learners provide deference to high-status individuals in order to ingratiate themselves with, and gain extended exposure to, that individual. We examined prestige-biased social transmission in a laboratory experiment in which participants designed arrowheads and attempted to maximize hunting success, measured in caloric return. Our main findings are that (1) participants preferentially learned from prestigious models (defined as those models at whom others spent longer times looking), and (2) prestige information and success-related information were used to the same degree, even though the former was less useful in this experiment than the latter. We also found that (3) participants were most likely to use social learning over individual (asocial) learning when they were performing poorly, in line with previous experiments, and (4) prestige information was not used more often following environmental shifts, contrary to predictions.  These results support previous discussions of the key role that prestige-biased transmission plays in social learning.

  18. 46 CFR 120.354 - Battery installations.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 46 Shipping 4 2010-10-01 2010-10-01 false Battery installations. 120.354 Section 120.354 Shipping... and Distribution Systems § 120.354 Battery installations. (a) Large batteries. Each large battery installation must be located in a locker, room or enclosed box solely dedicated to the storage of batteries...

  19. 46 CFR 120.354 - Battery installations.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 46 Shipping 4 2014-10-01 2014-10-01 false Battery installations. 120.354 Section 120.354 Shipping... and Distribution Systems § 120.354 Battery installations. (a) Large batteries. Each large battery installation must be located in a locker, room or enclosed box solely dedicated to the storage of batteries...

  20. 46 CFR 120.354 - Battery installations.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 46 Shipping 4 2011-10-01 2011-10-01 false Battery installations. 120.354 Section 120.354 Shipping... and Distribution Systems § 120.354 Battery installations. (a) Large batteries. Each large battery installation must be located in a locker, room or enclosed box solely dedicated to the storage of batteries...

  1. 46 CFR 120.354 - Battery installations.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 46 Shipping 4 2013-10-01 2013-10-01 false Battery installations. 120.354 Section 120.354 Shipping... and Distribution Systems § 120.354 Battery installations. (a) Large batteries. Each large battery installation must be located in a locker, room or enclosed box solely dedicated to the storage of batteries...

  2. 46 CFR 120.354 - Battery installations.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 46 Shipping 4 2012-10-01 2012-10-01 false Battery installations. 120.354 Section 120.354 Shipping... and Distribution Systems § 120.354 Battery installations. (a) Large batteries. Each large battery installation must be located in a locker, room or enclosed box solely dedicated to the storage of batteries...

  3. [Estimation of the number of minimum salaries attributed to professions in function of their prestige].

    PubMed

    Sousa, F A; da Silva, J A

    2000-04-01

    The purpose of this study was to verify the relationship between professional prestige scaled through estimations and the professional prestige scaled through estimation of the number of minimum salaries attributed to professions in function of their prestige in society. Results showed: 1--the relationship between the estimation of magnitudes and the estimation of the number of minimum salaries attributed to the professions in function of their prestige is characterized by a function of potence with an exponent lower than 1,0,2--the orders of degrees of prestige of the professions resultant from different experiments involving different samples of subjects are highly concordant (W = 0.85; p < 0.001), considering the modality used as a number (estimation of magnitudes of minimum salaries).

  4. The quarantine bay 4RC CO/sub 2/ WAG pilot project: A postflood evaluation

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Hsie, J.C.; Moore, J.S.

    1988-08-01

    This paper reviews the design, implementation, and performance of a miscible CO/sub 2/ water-alternating-gas (WAG) project in a U.S. gulf coast reservoir. The field-test obtained since the inception of the project in Oct. 1981 are presented, and solutions to such operational problems as downhole corrosion are discussed. Remarkable project response and recovery demonstrated that the CO/sub 2/ WAG process is technically viable for mobilizing considerable amounts of residual oil from watered-out Miocene reservoirs. A 16.9% recovery or original oil in place (OOIP) was obtained with a CO/sub 2/ slug size of 18.9% original HCPV. The CO/sub 2/ requirement was 2.57more » Mcf/bbl (458 m/sup 3//m/sup 3/) of oil recovered.« less

  5. 7 CFR 35.4 - Carrier.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 7 Agriculture 2 2011-01-01 2011-01-01 false Carrier. 35.4 Section 35.4 Agriculture Regulations of the Department of Agriculture AGRICULTURAL MARKETING SERVICE (Standards, Inspections, Marketing Practices), DEPARTMENT OF AGRICULTURE COMMODITY STANDARDS AND STANDARD CONTAINER REGULATIONS EXPORT GRAPES...

  6. 13 CFR 120.354 - Creditworthiness.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 120.354 Business Credit and Assistance SMALL BUSINESS ADMINISTRATION BUSINESS LOANS Special Purpose Loans Qualified Employee Trusts (esop) § 120.354 Creditworthiness. In determining repayment ability, SBA... earnings history and projected future earnings of the employer small business. SBA may consider the...

  7. 13 CFR 120.354 - Creditworthiness.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 120.354 Business Credit and Assistance SMALL BUSINESS ADMINISTRATION BUSINESS LOANS Special Purpose Loans Qualified Employee Trusts (esop) § 120.354 Creditworthiness. In determining repayment ability, SBA... earnings history and projected future earnings of the employer small business. SBA may consider the...

  8. 13 CFR 120.354 - Creditworthiness.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 120.354 Business Credit and Assistance SMALL BUSINESS ADMINISTRATION BUSINESS LOANS Special Purpose Loans Qualified Employee Trusts (esop) § 120.354 Creditworthiness. In determining repayment ability, SBA... earnings history and projected future earnings of the employer small business. SBA may consider the...

  9. 13 CFR 120.354 - Creditworthiness.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 120.354 Business Credit and Assistance SMALL BUSINESS ADMINISTRATION BUSINESS LOANS Special Purpose Loans Qualified Employee Trusts (esop) § 120.354 Creditworthiness. In determining repayment ability, SBA... earnings history and projected future earnings of the employer small business. SBA may consider the...

  10. Seismic tremors and magma wagging during explosive volcanism.

    PubMed

    Jellinek, A Mark; Bercovici, David

    2011-02-24

    Volcanic tremor is a ubiquitous feature of explosive eruptions. This oscillation persists for minutes to weeks and is characterized by a remarkably narrow band of frequencies from about 0.5 Hz to 7 Hz (refs 1-4). Before major eruptions, tremor can occur in concert with increased gas flux and related ground deformation. Volcanic tremor is thus of particular value for eruption forecasting. Most models for volcanic tremor rely on specific properties of the geometry, structure and constitution of volcanic conduits as well as the gas content of the erupting magma. Because neither the initial structure nor the evolution of the magma-conduit system will be the same from one volcano to the next, it is surprising that tremor characteristics are so consistent among different volcanoes. Indeed, this universality of tremor properties remains a major enigma. Here we employ the contemporary view that silicic magma rises in the conduit as a columnar plug surrounded by a highly vesicular annulus of sheared bubbles. We demonstrate that, for most geologically relevant conditions, the magma column will oscillate or 'wag' against the restoring 'gas-spring' force of the annulus at observed tremor frequencies. In contrast to previous models, the magma-wagging oscillation is relatively insensitive to the conduit structure and geometry, which explains the narrow band of tremor frequencies observed around the world. Moreover, the model predicts that as an eruption proceeds there will be an upward drift in both the maximum frequency and the total signal frequency bandwidth, the nature of which depends on the explosivity of the eruption, as is often observed.

  11. 13 CFR 120.354 - Creditworthiness.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... earnings history and projected future earnings of the employer small business. SBA may consider the... 13 Business Credit and Assistance 1 2010-01-01 2010-01-01 false Creditworthiness. 120.354 Section 120.354 Business Credit and Assistance SMALL BUSINESS ADMINISTRATION BUSINESS LOANS Special Purpose...

  12. 28 CFR 115.354 - Third-party reporting.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 28 Judicial Administration 2 2014-07-01 2014-07-01 false Third-party reporting. 115.354 Section 115.354 Judicial Administration DEPARTMENT OF JUSTICE (CONTINUED) PRISON RAPE ELIMINATION ACT NATIONAL STANDARDS Standards for Juvenile Facilities Reporting § 115.354 Third-party reporting. The agency shall...

  13. 28 CFR 115.354 - Third-party reporting.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 28 Judicial Administration 2 2012-07-01 2012-07-01 false Third-party reporting. 115.354 Section 115.354 Judicial Administration DEPARTMENT OF JUSTICE (CONTINUED) PRISON RAPE ELIMINATION ACT NATIONAL STANDARDS Standards for Juvenile Facilities Reporting § 115.354 Third-party reporting. The agency shall...

  14. 28 CFR 115.354 - Third-party reporting.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 28 Judicial Administration 2 2013-07-01 2013-07-01 false Third-party reporting. 115.354 Section 115.354 Judicial Administration DEPARTMENT OF JUSTICE (CONTINUED) PRISON RAPE ELIMINATION ACT NATIONAL STANDARDS Standards for Juvenile Facilities Reporting § 115.354 Third-party reporting. The agency shall...

  15. A Prestige Scale for Agricultural Occupations.

    ERIC Educational Resources Information Center

    Cosby, Arthur G.; Frank, Lianne M.

    A prestige scale for 50 agricultural and agriculturally related occupations was developed. The scale was constructed utilizing data from a mailed-questionnaire survey conducted during the spring semester of 1977 at 14 universities in the Southern United States. A 15% random sample of undergraduate majors in agriculture at these schools were…

  16. Occupational Sex Roles and Occupational Prestige.

    ERIC Educational Resources Information Center

    Simerly, D. Emily; Ruback, R. Barry

    Past studies on the sex-typing of occupations have used a single bipolar scale, ranging from masculinity to femininity. An empirical examination of both occupational sex roles and occupational prestige was conducted using two unipolar scales to assess masculinity and femininity. College students (N=183) rated 94 occupations, which were then…

  17. The Strange Game of Prestige Scholarships

    ERIC Educational Resources Information Center

    Knox, John A.

    2017-01-01

    Honors programs, as home to the highest test scores and highest GPAs on many campuses (for reasons that are not particularly justifiable), can become assembly lines for prestige-scholarship applications and their dangling appendages, the applicants themselves. As honors programs become cogs in universities' PR machines, they decouple from their…

  18. Why do early adolescents bully? Exploring the influence of prestige norms on social and psychological motives to bully.

    PubMed

    Berger, Christian; Caravita, Simona C S

    2016-01-01

    The present study examines psychological (e.g., Machiavellianism) and social (i.e., perceived popularity) motives for bullying, exploring the effects that classroom prestige norms for physical and relational aggression may have on these associations. A longitudinal multilevel study design was adopted, which included 978 5th to 7th graders from four Chilean schools. Participants were assessed three times over one year on self reports on bullying and Machiavellianism, and peer reports on popularity. Classroom prestige norms were calculated as the within classroom association between peer perceived coolness and aggression. Both Machiavellianism and perceived popularity were associated with bullying. However, hierarchical linear modeling analyses showed that Machiavellianism, but not perceived popularity, predicted bullying after controlling for baseline scores. Classroom prestige norms for relational aggression increased the association between Machiavellianism and bullying. Separate models were tested for boys and girls, showing no differences. Results are discussed in light of conceptual and methodological considerations. Copyright © 2015 The Foundation for Professionals in Services for Adolescents. Published by Elsevier Ltd. All rights reserved.

  19. 9 CFR 354.3 - Administration.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 9 Animals and Animal Products 2 2013-01-01 2013-01-01 false Administration. 354.3 Section 354.3 Animals and Animal Products FOOD SAFETY AND INSPECTION SERVICE, DEPARTMENT OF AGRICULTURE AGENCY... provisions of the regulations to permit experimentation so that new procedures, equipment, and processing...

  20. Avenues to Prestige among Adolescents in Public and Religiously Affiliated High Schools

    ERIC Educational Resources Information Center

    Suitor, J. Jill; Powers, Rebecca S.; Brown, Rachel

    2004-01-01

    We used data from 1,733 college students to explore whether adolescents' avenues to prestige differ in public and private high schools. Students attending seven large universities during the 1997-98 academic year provided information on the ways in which adolescents in their high schools had gained prestige with peers. The analyses revealed no…

  1. 9 CFR 354.245 - Vermin.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 9 Animals and Animal Products 2 2011-01-01 2011-01-01 false Vermin. 354.245 Section 354.245 Animals and Animal Products FOOD SAFETY AND INSPECTION SERVICE, DEPARTMENT OF AGRICULTURE AGENCY... exclude flies, rats, mice, and other vermin from the official plant. Dogs, cats, and other pets shall be...

  2. 9 CFR 354.226 - Lighting and ventilation.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 9 Animals and Animal Products 2 2011-01-01 2011-01-01 false Lighting and ventilation. 354.226 Section 354.226 Animals and Animal Products FOOD SAFETY AND INSPECTION SERVICE, DEPARTMENT OF AGRICULTURE... Facilities § 354.226 Lighting and ventilation. There shall be ample light, either natural or artificial or...

  3. 9 CFR 354.128 - Certification of carcasses.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 9 Animals and Animal Products 2 2010-01-01 2010-01-01 false Certification of carcasses. 354.128 Section 354.128 Animals and Animal Products FOOD SAFETY AND INSPECTION SERVICE, DEPARTMENT OF AGRICULTURE... Inspection § 354.128 Certification of carcasses. Each carcass and all parts and organs thereof which are...

  4. Maternal care affects EEG properties of spike-wave seizures (including pre- and post ictal periods) in adult WAG/Rij rats with genetic predisposition to absence epilepsy.

    PubMed

    Sitnikova, Evgenia; Rutskova, Elizaveta M; Raevsky, Vladimir V

    2016-10-01

    WAG/Rij rats have a genetic predisposition to absence epilepsy and develop spontaneous spike-wave discharges in EEG during late ontogenesis (SWD, EEG manifestation of absence epilepsy). Changes in an environment during early postnatal ontogenesis can influence the genetically predetermined absence epilepsy. Here we examined the effect of maternal environment during weaning period on the EEG manifestation of absence epilepsy in adulthood. Experiments were performed in the offspring of WAG/Rij and Wistar rats. The newborn pups were fostered to dams of the same (in-fostering) or another strain (cross-fostering). Age-matched control WAG/Rij and Wistar rats were reared by their biological mothers. Absence seizures were uncommon in Wistar and were not aggravated in both in- and cross-fostered groups. In WAG/Rij rats, fewer SWD were found in the cross-fostered as compared to the in-fostered group. The cross-fostered WAG/Rij rats showed higher percentage of short-lasting SWD with duration <2s. The mean frequency of EEG at the beginning of SWD in the cross-fostered WAG/Rij rats was lower than in control (8.82 vs 9.25Hz), but it was higher in a period of 1.5s before and after SWD. It was concluded that a healthier maternal environment is able to alleviate genetically predetermined absence seizures in adulthood through changes in EEG rhythmic activity. Copyright © 2016 Elsevier Inc. All rights reserved.

  5. 44 CFR 354.7 - Failure to pay.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 44 Emergency Management and Assistance 1 2014-10-01 2014-10-01 false Failure to pay. 354.7 Section 354.7 Emergency Management and Assistance FEDERAL EMERGENCY MANAGEMENT AGENCY, DEPARTMENT OF HOMELAND... PROGRAM § 354.7 Failure to pay. Where a licensee fails to pay a prescribed fee required under this part...

  6. 44 CFR 354.7 - Failure to pay.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 44 Emergency Management and Assistance 1 2011-10-01 2011-10-01 false Failure to pay. 354.7 Section 354.7 Emergency Management and Assistance FEDERAL EMERGENCY MANAGEMENT AGENCY, DEPARTMENT OF HOMELAND... PROGRAM § 354.7 Failure to pay. Where a licensee fails to pay a prescribed fee required under this part...

  7. 44 CFR 354.7 - Failure to pay.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 44 Emergency Management and Assistance 1 2013-10-01 2013-10-01 false Failure to pay. 354.7 Section 354.7 Emergency Management and Assistance FEDERAL EMERGENCY MANAGEMENT AGENCY, DEPARTMENT OF HOMELAND... PROGRAM § 354.7 Failure to pay. Where a licensee fails to pay a prescribed fee required under this part...

  8. 44 CFR 354.7 - Failure to pay.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 44 Emergency Management and Assistance 1 2012-10-01 2011-10-01 true Failure to pay. 354.7 Section 354.7 Emergency Management and Assistance FEDERAL EMERGENCY MANAGEMENT AGENCY, DEPARTMENT OF HOMELAND... PROGRAM § 354.7 Failure to pay. Where a licensee fails to pay a prescribed fee required under this part...

  9. 44 CFR 354.7 - Failure to pay.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 44 Emergency Management and Assistance 1 2010-10-01 2010-10-01 false Failure to pay. 354.7 Section 354.7 Emergency Management and Assistance FEDERAL EMERGENCY MANAGEMENT AGENCY, DEPARTMENT OF HOMELAND... PROGRAM § 354.7 Failure to pay. Where a licensee fails to pay a prescribed fee required under this part...

  10. The Quarantine Bay 4RC CO/sub 2/-WAG pilot project: A post-flood evaluation

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Hsie, J.C.; Moore, J.S.

    1986-01-01

    This paper reviews the design, implementation, and performance of a miscible CO/sub 2/ - WAG (water-alternating-gas) project in a Gulf Coast reservoir. The field test data obtained since the inception of the project in October 1981 are presented, and solutions to operational problems such as downhole corrosion are discussed. Remarkable project response and recovery demonstrated that the CO/sub 2/-WAG process is technically viable for mobilizing considerable amounts of residual oil from watered-out Miocene reservoirs. A 14.7% recovery of original-oil-in-place (OOIP) was obtained using a CO/sub 2/ slug size of 18.9% original hydrocarbon pore volume (HCPV). The CO/sub 2/ requirement wasmore » 2.95 Mcf/bbl (531 m/sup 3//m/sup 3/) of oil recovered.« less

  11. Teachers' Prestige in Spain: Probing the Public's and the Teachers' Contrary Views

    ERIC Educational Resources Information Center

    Pérez-Díaz, Víctor; Rodríguez, Juan Carlos

    2014-01-01

    We use the results of a public opinion survey we carried out in 2012 on a sample of the Spanish adult population to offer a plausible explanation of one of the main conundrums of primary and secondary school teachers' prestige, not only in Spain, i.e. that, contrary to public discourse and to teachers' perceptions, this prestige has not fallen in…

  12. Understanding the relation between socioeconomic position and inflammation in post-menopausal women: education, income and occupational prestige.

    PubMed

    Pedersen, Jolene Masters; Budtz-Jørgensen, Esben; De Roos, Anneclaire; Garcia, Lorena; Lund, Rikke; Rod, Naja Hulvej; Kroenke, Candyce; Chan, Kei Hang Katie; Liu, Simin; Michael, Yvonne

    2017-12-01

    The role of occupational prestige, a direct measure of the perceived status of job and job holder, in inflammation is unknown. To contribute to understanding the pathways by which socioeconomic position (SEP) is associated with inflammation, we aimed to estimate the direct effects of education, income and occupational prestige on C-reactive protein (CRP) and to describe the relationship between these markers and CRP. The study was based on 2026 post-menopausal women enrolled in the Women's Health Initiative-Observational Study. Occupational prestige was determined by linking a text description of longest held occupation with a social status item from the Occupational Information Network. Path analysis was employed to estimate direct and mediated effects. The study suggests that higher levels of education, income, and occupational prestige are associated with 8% (95% CI as percentage change -12, -4), 5% [95% CI (-8, -2) and 4% (95% CI - 7, -1)] lower levels of CRP, respectively. The inverse association between education and CRP was explained by the effect of education on income and occupational prestige. The effect of occupational prestige on CRP was independent of mediators in the model. The findings indicate that education may work to influence CRP primarily through increasing income and occupational prestige and provides evidence that occupational prestige captures a unique aspect of SEP. © The Author 2017. Published by Oxford University Press on behalf of the European Public Health Association. All rights reserved.

  13. Decreased ERp57 Expression in WAG/Rij Rats Thalamus and Cortex; Possible Correlation with Absence Epilepsy.

    PubMed

    Sahin, Deniz; Karadenizli, Sabriye; Kasap, Murat; Oztas, Berrin; Kir, Hale Maral; Akpinar, Gurler; Ates, Nurbay

    2018-02-06

    The role of intracellular proteins in the pathogenesis of absence epilepsy were mentioned. These proteins are thought to be related to energy generation, signal transduction, inflammation processes and membrane conductance. The investigation of protein profile of the genetically epileptic rat brains was the main subject of this study. For this, a 2D-gel electrophoresis based comparative proteome analysis was performed using thalamus tissue of genetic absence epileptic WAG/Rij and age matched Wistar rats. Regulated spots displaying differences in their abundance were identified using MALDI-TOF/TOF. Among the six spots (DHRS9, BR44, HINT1, CREM, SPRE and PDIA3/ERp57) the highest mascot score was attributed to ERp57 a neuroprotective/neurodegenerative system associated protein. Western Blot analyses were performed to validate changes occurring at ERp57 in thalamus and also identify changes in fronto-parietal cortex. Reductions in the expression levels of ERp57 were detected in the thalamic and the fronto-parietal brain regions of the WAG/Rij rats in comparison to Wistar rats. Such difference might be associated with the pathogenic mechanisms dictating the absence epilepsy. Lower levels of ERp57 may be playing an important role in the development of spontaneous seizures activity seen in the absence epileptic WAG/Rij rats strain. Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.org.

  14. WAG 2 remedial investigation and site investigation site-specific work plan/health and safety checklist for the ecological assessment task, Kingfisher Study

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Holt, V.L.; Baron, L.A.

    1994-05-01

    This report provides specific details and requirements for the WAG 2 remedial investigation and site investigation Ecological Assessment Task, Kingfisher Study, including information that will contribute to safe completion of the project. The report includes historical background; a site map; project organization; task descriptions and hazard evaluations; controls; and monitoring, personal protective equipment, decontamination, and medical surveillance program requirements. The report also includes descriptions of site personnel and their certifications as well as suspected WAG 2 contaminants and their characteristics. The primary objective of the WAG 2 Kingfisher Study is to assess the feasibility of using kingfishers as biological monitorsmore » of contaminants on the Oak Ridge Reservation (ORR). Kingfisher sample collection will be used to determine the levels of contaminants and degree of bioaccumulation within a common piscivorous bird feeding on contaminated fish from streams on the ORR.« less

  15. 5 CFR 9701.354 - Setting pay upon demotion.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 5 Administrative Personnel 3 2010-01-01 2010-01-01 false Setting pay upon demotion. 9701.354 Section 9701.354 Administrative Personnel DEPARTMENT OF HOMELAND SECURITY HUMAN RESOURCES MANAGEMENT... HUMAN RESOURCES MANAGEMENT SYSTEM Pay and Pay Administration Pay Administration § 9701.354 Setting pay...

  16. 19 CFR 354.11 - Prehearing conference.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 19 Customs Duties 3 2011-04-01 2011-04-01 false Prehearing conference. 354.11 Section 354.11 Customs Duties INTERNATIONAL TRADE ADMINISTRATION, DEPARTMENT OF COMMERCE PROCEDURES FOR IMPOSING...) Obtaining stipulations of fact and of documents to avoid unnecessary proof; (iii) Settlement of the matter...

  17. 19 CFR 354.11 - Prehearing conference.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 19 Customs Duties 3 2012-04-01 2012-04-01 false Prehearing conference. 354.11 Section 354.11 Customs Duties INTERNATIONAL TRADE ADMINISTRATION, DEPARTMENT OF COMMERCE PROCEDURES FOR IMPOSING...) Obtaining stipulations of fact and of documents to avoid unnecessary proof; (iii) Settlement of the matter...

  18. 19 CFR 354.11 - Prehearing conference.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 19 Customs Duties 3 2013-04-01 2013-04-01 false Prehearing conference. 354.11 Section 354.11 Customs Duties INTERNATIONAL TRADE ADMINISTRATION, DEPARTMENT OF COMMERCE PROCEDURES FOR IMPOSING...) Obtaining stipulations of fact and of documents to avoid unnecessary proof; (iii) Settlement of the matter...

  19. 19 CFR 354.11 - Prehearing conference.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 19 Customs Duties 3 2010-04-01 2010-04-01 false Prehearing conference. 354.11 Section 354.11 Customs Duties INTERNATIONAL TRADE ADMINISTRATION, DEPARTMENT OF COMMERCE PROCEDURES FOR IMPOSING...) Obtaining stipulations of fact and of documents to avoid unnecessary proof; (iii) Settlement of the matter...

  20. 19 CFR 354.11 - Prehearing conference.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 19 Customs Duties 3 2014-04-01 2014-04-01 false Prehearing conference. 354.11 Section 354.11 Customs Duties INTERNATIONAL TRADE ADMINISTRATION, DEPARTMENT OF COMMERCE PROCEDURES FOR IMPOSING...) Obtaining stipulations of fact and of documents to avoid unnecessary proof; (iii) Settlement of the matter...

  1. Do diseases have a prestige hierarchy? A survey among physicians and medical students.

    PubMed

    Album, Dag; Westin, Steinar

    2008-01-01

    Surveys have shown that the prestige of medical specialities is ordered hierarchically. We investigate whether similar tacit agreement in the medical community also applies to diseases, since such rankings can affect priority settings in medical practice. A cross-sectional survey was performed in three samples of physicians and medical students in Norway in 2002. A questionnaire was sent to 305 senior doctors (response rate, 79%), 500 general practitioners (response rate, 65%) and 490 final-year medical students (response rate, 64%). Outcome measures were ratings on a 1-9 scale of the prestige these respondents believed most health personnel would accord to a sample set of 38 different diseases as well as 23 medical specialities. Both diseases and specialities were clearly and consistently ranked according to prestige. Myocardial infarction, leukaemia and brain tumour were among the highest ranked, and fibromyalgia and anxiety neurosis were among the lowest. Among specialities, neurosurgery and thoracic surgery were accorded the highest rank, and geriatrics and dermatovenerology the lowest. Our interpretation of the data is that diseases and specialities associated with technologically sophisticated, immediate and invasive procedures in vital organs located in the upper parts of the body are given high prestige scores, especially where the typical patient is young or middle-aged. At the other end, low prestige scores are given to diseases and specialities associated with chronic conditions located in the lower parts of the body or having no specific bodily location, with less visible treatment procedures, and with elderly patients.

  2. 9 CFR 354.124 - Quarantine of diseased rabbits.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 9 Animals and Animal Products 2 2012-01-01 2012-01-01 false Quarantine of diseased rabbits. 354.124 Section 354.124 Animals and Animal Products FOOD SAFETY AND INSPECTION SERVICE, DEPARTMENT OF... Procedures; Ante-Mortem Inspections § 354.124 Quarantine of diseased rabbits. If live rabbits, which are...

  3. 9 CFR 354.124 - Quarantine of diseased rabbits.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 9 Animals and Animal Products 2 2013-01-01 2013-01-01 false Quarantine of diseased rabbits. 354.124 Section 354.124 Animals and Animal Products FOOD SAFETY AND INSPECTION SERVICE, DEPARTMENT OF... Procedures; Ante-Mortem Inspections § 354.124 Quarantine of diseased rabbits. If live rabbits, which are...

  4. 9 CFR 354.124 - Quarantine of diseased rabbits.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 9 Animals and Animal Products 2 2014-01-01 2014-01-01 false Quarantine of diseased rabbits. 354.124 Section 354.124 Animals and Animal Products FOOD SAFETY AND INSPECTION SERVICE, DEPARTMENT OF... Procedures; Ante-Mortem Inspections § 354.124 Quarantine of diseased rabbits. If live rabbits, which are...

  5. 42 CFR 495.354 - Rules for charging equipment.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 42 Public Health 5 2010-10-01 2010-10-01 false Rules for charging equipment. 495.354 Section 495.354 Public Health CENTERS FOR MEDICARE & MEDICAID SERVICES, DEPARTMENT OF HEALTH AND HUMAN SERVICES... PROGRAM Requirements Specific to the Medicaid Program § 495.354 Rules for charging equipment. Equipment...

  6. 9 CFR 354.246 - Exclusion of diseased persons.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 9 Animals and Animal Products 2 2010-01-01 2010-01-01 false Exclusion of diseased persons. 354.246 Section 354.246 Animals and Animal Products FOOD SAFETY AND INSPECTION SERVICE, DEPARTMENT OF AGRICULTURE... Sanitary Conditions and Precautions Against Contamination of Products § 354.246 Exclusion of diseased...

  7. The Big Man Mechanism: how prestige fosters cooperation and creates prosocial leaders.

    PubMed

    Henrich, Joseph; Chudek, Maciej; Boyd, Robert

    2015-12-05

    Anthropological evidence from diverse societies suggests that prestige-based leadership may provide a foundation for cooperation in many contexts. Here, inspired by such ethnographic observations and building on a foundation of existing research on the evolution of prestige, we develop a set of formal models to explore when an evolved prestige psychology might drive the cultural evolution of n-person cooperation, and how such a cultural evolutionary process might create novel selection pressures for genes that make prestigious individuals more prosocial. Our results reveal (i) how prestige can foster the cultural emergence of cooperation by generating correlated behavioural phenotypes, both between leaders and followers, and among followers; (ii) why, in the wake of cultural evolution, natural selection favours genes that make prestigious leaders more prosocial, but only when groups are relatively small; and (iii), why the effectiveness of status differences in generating cooperation in large groups depends on cultural transmission (and not primarily on deference or coercion). Our theoretical framework, and the specific predictions made by these models, sketch out an interdisciplinary research programme that cross-cuts anthropology, biology, psychology and economics. Some of our predictions find support from laboratory work in behavioural economics and are consistent with several real-world patterns. © 2015 The Authors.

  8. The Big Man Mechanism: how prestige fosters cooperation and creates prosocial leaders

    PubMed Central

    Henrich, Joseph; Chudek, Maciej; Boyd, Robert

    2015-01-01

    Anthropological evidence from diverse societies suggests that prestige-based leadership may provide a foundation for cooperation in many contexts. Here, inspired by such ethnographic observations and building on a foundation of existing research on the evolution of prestige, we develop a set of formal models to explore when an evolved prestige psychology might drive the cultural evolution of n-person cooperation, and how such a cultural evolutionary process might create novel selection pressures for genes that make prestigious individuals more prosocial. Our results reveal (i) how prestige can foster the cultural emergence of cooperation by generating correlated behavioural phenotypes, both between leaders and followers, and among followers; (ii) why, in the wake of cultural evolution, natural selection favours genes that make prestigious leaders more prosocial, but only when groups are relatively small; and (iii), why the effectiveness of status differences in generating cooperation in large groups depends on cultural transmission (and not primarily on deference or coercion). Our theoretical framework, and the specific predictions made by these models, sketch out an interdisciplinary research programme that cross-cuts anthropology, biology, psychology and economics. Some of our predictions find support from laboratory work in behavioural economics and are consistent with several real-world patterns. PMID:26503686

  9. 42 CFR 35.4 - Noncompliance; discharge or transfer.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 42 Public Health 1 2013-10-01 2013-10-01 false Noncompliance; discharge or transfer. 35.4 Section 35.4 Public Health PUBLIC HEALTH SERVICE, DEPARTMENT OF HEALTH AND HUMAN SERVICES MEDICAL CARE AND EXAMINATIONS HOSPITAL AND STATION MANAGEMENT General § 35.4 Noncompliance; discharge or transfer. (a) If the...

  10. 42 CFR 35.4 - Noncompliance; discharge or transfer.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 42 Public Health 1 2010-10-01 2010-10-01 false Noncompliance; discharge or transfer. 35.4 Section 35.4 Public Health PUBLIC HEALTH SERVICE, DEPARTMENT OF HEALTH AND HUMAN SERVICES MEDICAL CARE AND EXAMINATIONS HOSPITAL AND STATION MANAGEMENT General § 35.4 Noncompliance; discharge or transfer. (a) If the...

  11. 42 CFR 35.4 - Noncompliance; discharge or transfer.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 42 Public Health 1 2014-10-01 2014-10-01 false Noncompliance; discharge or transfer. 35.4 Section 35.4 Public Health PUBLIC HEALTH SERVICE, DEPARTMENT OF HEALTH AND HUMAN SERVICES MEDICAL CARE AND EXAMINATIONS HOSPITAL AND STATION MANAGEMENT General § 35.4 Noncompliance; discharge or transfer. (a) If the...

  12. 42 CFR 35.4 - Noncompliance; discharge or transfer.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 42 Public Health 1 2012-10-01 2012-10-01 false Noncompliance; discharge or transfer. 35.4 Section 35.4 Public Health PUBLIC HEALTH SERVICE, DEPARTMENT OF HEALTH AND HUMAN SERVICES MEDICAL CARE AND EXAMINATIONS HOSPITAL AND STATION MANAGEMENT General § 35.4 Noncompliance; discharge or transfer. (a) If the...

  13. 42 CFR 35.4 - Noncompliance; discharge or transfer.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 42 Public Health 1 2011-10-01 2011-10-01 false Noncompliance; discharge or transfer. 35.4 Section 35.4 Public Health PUBLIC HEALTH SERVICE, DEPARTMENT OF HEALTH AND HUMAN SERVICES MEDICAL CARE AND EXAMINATIONS HOSPITAL AND STATION MANAGEMENT General § 35.4 Noncompliance; discharge or transfer. (a) If the...

  14. 9 CFR 354.224 - Water supply.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 9 Animals and Animal Products 2 2011-01-01 2011-01-01 false Water supply. 354.224 Section 354.224....224 Water supply. The water supply shall be ample, clean, and potable with adequate facilities for its distribution in the plant and its protection against contamination and pollution. (a) Hot water at a...

  15. 9 CFR 354.224 - Water supply.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 9 Animals and Animal Products 2 2010-01-01 2010-01-01 false Water supply. 354.224 Section 354.224....224 Water supply. The water supply shall be ample, clean, and potable with adequate facilities for its distribution in the plant and its protection against contamination and pollution. (a) Hot water at a...

  16. 9 CFR 354.224 - Water supply.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 9 Animals and Animal Products 2 2012-01-01 2012-01-01 false Water supply. 354.224 Section 354.224....224 Water supply. The water supply shall be ample, clean, and potable with adequate facilities for its distribution in the plant and its protection against contamination and pollution. (a) Hot water at a...

  17. 9 CFR 354.224 - Water supply.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 9 Animals and Animal Products 2 2014-01-01 2014-01-01 false Water supply. 354.224 Section 354.224....224 Water supply. The water supply shall be ample, clean, and potable with adequate facilities for its distribution in the plant and its protection against contamination and pollution. (a) Hot water at a...

  18. 9 CFR 354.224 - Water supply.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 9 Animals and Animal Products 2 2013-01-01 2013-01-01 false Water supply. 354.224 Section 354.224....224 Water supply. The water supply shall be ample, clean, and potable with adequate facilities for its distribution in the plant and its protection against contamination and pollution. (a) Hot water at a...

  19. Identity Strategies in Light of a Low-Prestige Occupation: The Case of Retail Apprentices

    ERIC Educational Resources Information Center

    Duemmler, Kerstin; Caprani, Isabelle

    2017-01-01

    Occupations differ in their prestige, but little research has examined how workers manage working in a low-prestige occupation. This case study with retail-clerk apprentices in Switzerland uncovers the identity strategies the apprentices employ to help them normalise the situation they find themselves in: they are learning an occupation that is…

  20. Age-dependent seizures of absence epilepsy and sleep spindles dynamics in WAG/Rij rats

    NASA Astrophysics Data System (ADS)

    Grubov, Vadim V.; Sitnikova, Evgenia Y.; Pavlov, Alexey N.; Khramova, Marina V.; Koronovskii, Alexey A.; Hramov, Alexander E.

    2015-03-01

    In the given paper, a relation between time-frequency characteristics of sleep spindles and the age-dependent epileptic activity in WAG/Rij rats is discussed. Analysis of sleep spindles based on the continuous wavelet transform is performed for rats of different ages. It is shown that the epileptic activity affects the time-frequency intrinsic dynamics of sleep spindles.

  1. 9 CFR 354.133 - Reinspection of edible products; ingredients.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 9 Animals and Animal Products 2 2014-01-01 2014-01-01 false Reinspection of edible products; ingredients. 354.133 Section 354.133 Animals and Animal Products FOOD SAFETY AND INSPECTION SERVICE... Reinspection and Ingredients § 354.133 Reinspection of edible products; ingredients. (a) Any inspected and...

  2. 9 CFR 354.247 - Table showing types of materials.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 9 Animals and Animal Products 2 2010-01-01 2010-01-01 false Table showing types of materials. 354.247 Section 354.247 Animals and Animal Products FOOD SAFETY AND INSPECTION SERVICE, DEPARTMENT OF... Sanitary Conditions and Precautions Against Contamination of Products § 354.247 Table showing types of...

  3. 9 CFR 354.242 - Cleaning of equipment and utensils.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 9 Animals and Animal Products 2 2010-01-01 2010-01-01 false Cleaning of equipment and utensils. 354.242 Section 354.242 Animals and Animal Products FOOD SAFETY AND INSPECTION SERVICE, DEPARTMENT OF... Sanitary Conditions and Precautions Against Contamination of Products § 354.242 Cleaning of equipment and...

  4. 9 CFR 354.241 - Cleaning of rooms and compartments.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 9 Animals and Animal Products 2 2010-01-01 2010-01-01 false Cleaning of rooms and compartments. 354.241 Section 354.241 Animals and Animal Products FOOD SAFETY AND INSPECTION SERVICE, DEPARTMENT OF... Sanitary Conditions and Precautions Against Contamination of Products § 354.241 Cleaning of rooms and...

  5. 9 CFR 354.243 - Operations and procedures.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... Section 354.243 Animals and Animal Products FOOD SAFETY AND INSPECTION SERVICE, DEPARTMENT OF AGRICULTURE... Sanitary Conditions and Precautions Against Contamination of Products § 354.243 Operations and procedures... product against contamination by any foreign substance (including, but not being limited to, dust, dirt...

  6. 9 CFR 354.63 - Marking inspected products.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 9 Animals and Animal Products 2 2010-01-01 2010-01-01 false Marking inspected products. 354.63 Section 354.63 Animals and Animal Products FOOD SAFETY AND INSPECTION SERVICE, DEPARTMENT OF AGRICULTURE AGENCY ORGANIZATION AND TERMINOLOGY; MANDATORY MEAT AND POULTRY PRODUCTS INSPECTION AND VOLUNTARY...

  7. 9 CFR 354.126 - Carcasses held for further examination.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 9 Animals and Animal Products 2 2010-01-01 2010-01-01 false Carcasses held for further examination. 354.126 Section 354.126 Animals and Animal Products FOOD SAFETY AND INSPECTION SERVICE, DEPARTMENT OF... Inspection § 354.126 Carcasses held for further examination. Each carcass, including all parts thereof, in...

  8. 43 CFR 4.354 - Reconsideration or rehearing.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 43 Public Lands: Interior 1 2014-10-01 2014-10-01 false Reconsideration or rehearing. 4.354 Section 4.354 Public Lands: Interior Office of the Secretary of the Interior DEPARTMENT HEARINGS AND APPEALS PROCEDURES Rules Applicable in Indian Affairs Hearings and Appeals White Earth Reservation Land...

  9. 43 CFR 4.354 - Reconsideration or rehearing.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 43 Public Lands: Interior 1 2013-10-01 2013-10-01 false Reconsideration or rehearing. 4.354 Section 4.354 Public Lands: Interior Office of the Secretary of the Interior DEPARTMENT HEARINGS AND APPEALS PROCEDURES Rules Applicable in Indian Affairs Hearings and Appeals White Earth Reservation Land...

  10. 43 CFR 4.354 - Reconsideration or rehearing.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 43 Public Lands: Interior 1 2011-10-01 2011-10-01 false Reconsideration or rehearing. 4.354 Section 4.354 Public Lands: Interior Office of the Secretary of the Interior DEPARTMENT HEARINGS AND APPEALS PROCEDURES Rules Applicable in Indian Affairs Hearings and Appeals White Earth Reservation Land...

  11. 43 CFR 4.354 - Reconsideration or rehearing.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 43 Public Lands: Interior 1 2010-10-01 2010-10-01 false Reconsideration or rehearing. 4.354 Section 4.354 Public Lands: Interior Office of the Secretary of the Interior DEPARTMENT HEARINGS AND APPEALS PROCEDURES Rules Applicable in Indian Affairs Hearings and Appeals White Earth Reservation Land...

  12. 25 CFR 1000.354 - What is a trust evaluation?

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... that the functions are performed in accordance with trust standards as defined by Federal law. Trust... 25 Indians 2 2010-04-01 2010-04-01 false What is a trust evaluation? 1000.354 Section 1000.354... Trust Evaluation Review Annual Trust Evaluations § 1000.354 What is a trust evaluation? A trust...

  13. Prestige versus citation volume as journal indices in cognitive neuroscience.

    PubMed

    Ward, Jamie

    2014-01-01

    In recent years, alternative measures of a journal's influence have been developed to those based on citation metrics (such as Impact Factor). This includes the Scimago Journal Rank (SJR) which is adapted from algorithms used to prioritize webpages in search engines. It is considered a measure of "prestige" insofar as it takes into account the importance of links/citations and not just their total number. Taking a sample of 38 journals from within the field of cognitive neuroscience, it is shown that SJR and Impact Factor correlate highly (r = .83) but with a few large discrepancies in rankings. This journal, Cognitive Neuroscience, fares better on the prestige-based measure than might otherwise be expected from its citation-based rank.

  14. Antisymmetric Amino-Wagging Band of Hydrazine up toK‧ = 13 Levels

    NASA Astrophysics Data System (ADS)

    Gulaczyk, Iwona; Kre, Marek; Valentin, Alain

    1997-12-01

    A newly recorded high-resolution infrared spectrum of hydrazine has been studied in the 729-1198 cm-1region (the ν12antisymmetric wagging band) with a resolution of 0.002 cm-1. About 1350 transitions withK‧ from 7 to 13 have been newly assigned and about 2350 transitions with lower values ofK‧ reanalyzed with the improved precision. The effective parameters have been calculated separately for each value ofK‧ using the Hougen-Ohashi hamiltonian for hydrazine. The extended assignment completes the analysis of the ν12band of hydrazine.

  15. 9 CFR 354.106 - Travel expenses and other charges.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 9 Animals and Animal Products 2 2010-01-01 2010-01-01 false Travel expenses and other charges. 354.106 Section 354.106 Animals and Animal Products FOOD SAFETY AND INSPECTION SERVICE, DEPARTMENT OF... § 354.106 Travel expenses and other charges. Charges are to be made to cover the cost of travel and...

  16. 31 CFR 354.8 - Waiver of regulations.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 31 Money and Finance:Treasury 2 2012-07-01 2012-07-01 false Waiver of regulations. 354.8 Section 354.8 Money and Finance: Treasury Regulations Relating to Money and Finance (Continued) FISCAL SERVICE... of unnecessary hardship, if such action is not inconsistent with law, does not adversely affect...

  17. 43 CFR 4.354 - Reconsideration or rehearing.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 43 Public Lands: Interior 1 2012-10-01 2011-10-01 true Reconsideration or rehearing. 4.354 Section 4.354 Public Lands: Interior Office of the Secretary of the Interior DEPARTMENT HEARINGS AND APPEALS PROCEDURES Rules Applicable in Indian Affairs Hearings and Appeals White Earth Reservation Land Settlement...

  18. 9 CFR 354.53 - Other applicable regulations.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 9 Animals and Animal Products 2 2010-01-01 2010-01-01 false Other applicable regulations. 354.53 Section 354.53 Animals and Animal Products FOOD SAFETY AND INSPECTION SERVICE, DEPARTMENT OF AGRICULTURE... excuse failure to comply with any other Federal or any State or municipal applicable laws or regulations...

  19. University Decision Making and Prestige: An Empirical Study

    ERIC Educational Resources Information Center

    Cyrenne, Philippe; Grant, Hugh

    2009-01-01

    In this paper, we examine the factors that influence the reputation or prestige of universities. We first develop a model of university behaviour which indicates how the decisions made by university officials would be chosen in order to maximize their respective reputations. In doing so, we assume that reputation is enhanced by the quality of…

  20. Oxidative Stress and Nano-Toxicity Induced by TiO2 and ZnO on WAG Cell Line

    PubMed Central

    Dubey, Akhilesh; Goswami, Mukunda; Yadav, Kamalendra; Chaudhary, Dharmendra

    2015-01-01

    Metallic nanoparticles are widely used in cosmetics, food products and textile industry. These particles are known to cause respiratory toxicity and epithelial inflammation. They are eventually released to aquatic environment necessitating toxicity studies in cells from respiratory organs of aquatic organisms. Hence, we have developed and characterized a new cell line, WAG, from gill tissue of Wallago attu for toxicity assessment of TiO2 and ZnO nanoparticles. The efficacy of the cell line as an in vitro system for nanoparticles toxicity studies was established using electron microscopy, cytotoxicity assays, genotoxicity assays and oxidative stress biomarkers. Results obtained with MTT assay, neutral red uptake assay and lactate dehydrogenase assay showed acute toxicity to WAG cells with IC50 values of 25.29±0.12, 34.99±0.09 and 35.06±0.09 mg/l for TiO2 and 5.716±0.1, 3.160±0.1 and 5.57±0.12 mg/l for ZnO treatment respectively. The physicochemical properties and size distribution of nanoparticles were characterized using electron microscopy with integrated energy dispersive X-ray spectroscopy and Zetasizer. Dose dependent increase in DNA damage, lipid peroxidation and protein carbonylation along with a significant decrease in activity of Superoxide Dismutase, Catalase, total Glutathione levels and total antioxidant capacity with increasing concentration of exposed nanoparticles indicated that the cells were under oxidative stress. The study established WAG cell line as an in vitro system to study toxicity mechanisms of nanoparticles on aquatic organisms. PMID:26011447

  1. 37 CFR 3.54 - Effect of recording.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 37 Patents, Trademarks, and Copyrights 1 2010-07-01 2010-07-01 false Effect of recording. 3.54... COMMERCE GENERAL ASSIGNMENT, RECORDING AND RIGHTS OF ASSIGNEE Date and Effect of Recording § 3.54 Effect of... validity of the document or the effect that document has on the title to an application, a patent, or a...

  2. 9 CFR 354.244 - Temperatures and cooling and freezing procedures.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 9 Animals and Animal Products 2 2010-01-01 2010-01-01 false Temperatures and cooling and freezing procedures. 354.244 Section 354.244 Animals and Animal Products FOOD SAFETY AND INSPECTION SERVICE... Maintenance of Sanitary Conditions and Precautions Against Contamination of Products § 354.244 Temperatures...

  3. Spatial distribution and ecotoxicity of petroleum hydrocarbons in sediments from the Galicia continental shelf (NW Spain) after the Prestige oil spill.

    PubMed

    Franco, M A; Viñas, L; Soriano, J A; de Armas, D; González, J J; Beiras, R; Salas, N; Bayona, J M; Albaigés, J

    2006-01-01

    The distribution of aliphatic and aromatic hydrocarbons was determined in surface sediments collected at 36 stations along the Galicia continental shelf (NW Spain), following the Prestige oil spill. Sampling was performed in December 2002, just after the accident, and in February and September 2003. Concentrations of PAHs (summation operator 13 parent components) were in the range of 0.9-422 microg/kgdw, the highest values being close to coastal urban areas (e.g. Pontevedra and A Coruña), whereas in the stations of the area most heavily impacted by the spill (off Costa da Morte) concentrations were in the range of 14.8-89.6 microg/kgdw, with a certain predominance of alkylated compounds, which may suggest a mixture of petrogenic and pyrolytic sources. The detailed study of petrogenic molecular markers (e.g. steranes and triterpanes) showed the occurrence of an old (weathered) petrogenic chronic pollution in the shelf sediments but not of the Prestige oil, with the possible exception of few stations in the area of Costa da Morte. This was attributed to the heavy nature of the spilled oil that was barely dispersed in the water column and mainly stranded on the coast or sedimented in the form of oil patches. The addition of increasing amounts of fuel oil to a representative sediment sample showed that the molecular indices were indicative of the presence of the Prestige oil when the amount was above 1g/kg of sediment. The toxicity of selected samples (showing the higher PAH concentrations) was tested using the bivalve embryogenesis bioassay. Embryogenesis success reached high values in all cases (80-88%, with 86% in the control), indicating a lack of toxicity in the sediments and supporting the conclusion that the patchiness of the fuel eventually reaching the seafloor reduced its impact on the benthic communities of the Galician shelf.

  4. 30 CFR 1206.354 - How do I determine generating deductions?

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 30 Mineral Resources 3 2012-07-01 2012-07-01 false How do I determine generating deductions? 1206.354 Section 1206.354 Mineral Resources OFFICE OF NATURAL RESOURCES REVENUE, DEPARTMENT OF THE INTERIOR NATURAL RESOURCES REVENUE PRODUCT VALUATION Geothermal Resources § 1206.354 How do I determine generating...

  5. 9 CFR 354.47 - Use of facsimile forms.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 9 Animals and Animal Products 2 2011-01-01 2011-01-01 false Use of facsimile forms. 354.47 Section 354.47 Animals and Animal Products FOOD SAFETY AND INSPECTION SERVICE, DEPARTMENT OF AGRICULTURE... certificate, symbol, stamp, label, seal or identification authorized to be issued or used under the...

  6. 9 CFR 354.47 - Use of facsimile forms.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 9 Animals and Animal Products 2 2010-01-01 2010-01-01 false Use of facsimile forms. 354.47 Section 354.47 Animals and Animal Products FOOD SAFETY AND INSPECTION SERVICE, DEPARTMENT OF AGRICULTURE... certificate, symbol, stamp, label, seal or identification authorized to be issued or used under the...

  7. 9 CFR 354.24 - Financial interest of inspectors.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 9 Animals and Animal Products 2 2010-01-01 2010-01-01 false Financial interest of inspectors. 354... INSPECTION AND CERTIFICATION VOLUNTARY INSPECTION OF RABBITS AND EDIBLE PRODUCTS THEREOF Performance of Services § 354.24 Financial interest of inspectors. No inspector shall render service on any product in...

  8. 32 CFR 644.354 - Conditional reports of excess.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... general policy, GSA has agreed with the Department of Defense to accept reports of excess on some... 32 National Defense 4 2012-07-01 2011-07-01 true Conditional reports of excess. 644.354 Section 644.354 National Defense Department of Defense (Continued) DEPARTMENT OF THE ARMY (CONTINUED) REAL...

  9. 32 CFR 644.354 - Conditional reports of excess.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... general policy, GSA has agreed with the Department of Defense to accept reports of excess on some... 32 National Defense 4 2014-07-01 2013-07-01 true Conditional reports of excess. 644.354 Section 644.354 National Defense Department of Defense (Continued) DEPARTMENT OF THE ARMY (CONTINUED) REAL...

  10. 32 CFR 644.354 - Conditional reports of excess.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... general policy, GSA has agreed with the Department of Defense to accept reports of excess on some... 32 National Defense 4 2013-07-01 2013-07-01 false Conditional reports of excess. 644.354 Section 644.354 National Defense Department of Defense (Continued) DEPARTMENT OF THE ARMY (CONTINUED) REAL...

  11. 32 CFR 644.354 - Conditional reports of excess.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... general policy, GSA has agreed with the Department of Defense to accept reports of excess on some... 32 National Defense 4 2011-07-01 2011-07-01 false Conditional reports of excess. 644.354 Section 644.354 National Defense Department of Defense (Continued) DEPARTMENT OF THE ARMY (CONTINUED) REAL...

  12. 32 CFR 644.354 - Conditional reports of excess.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... general policy, GSA has agreed with the Department of Defense to accept reports of excess on some... 32 National Defense 4 2010-07-01 2010-07-01 true Conditional reports of excess. 644.354 Section 644.354 National Defense Department of Defense (Continued) DEPARTMENT OF THE ARMY (CONTINUED) REAL...

  13. 31 CFR 354.3 - Law governing other interests.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... Section 354.3 Money and Finance: Treasury Regulations Relating to Money and Finance (Continued) FISCAL... OF THE STUDENT LOAN MARKETING ASSOCIATION (SALLIE MAE) § 354.3 Law governing other interests. (a) To... jurisdiction specified in paragraph (b) of this section is a State that has not adopted Revised Article 8...

  14. 9 CFR 354.90 - Report of inspection work.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 9 Animals and Animal Products 2 2011-01-01 2011-01-01 false Report of inspection work. 354.90 Section 354.90 Animals and Animal Products FOOD SAFETY AND INSPECTION SERVICE, DEPARTMENT OF AGRICULTURE... Report of inspection work. Reports of the work of inspection carried on within official plants shall be...

  15. 40 CFR 51.354 - Adequate tools and resources.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 40 Protection of Environment 2 2014-07-01 2014-07-01 false Adequate tools and resources. 51.354... Requirements § 51.354 Adequate tools and resources. (a) Administrative resources. The program shall maintain... assurance, data analysis and reporting, and the holding of hearings and adjudication of cases. A portion of...

  16. 40 CFR 51.354 - Adequate tools and resources.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 40 Protection of Environment 2 2011-07-01 2011-07-01 false Adequate tools and resources. 51.354... Requirements § 51.354 Adequate tools and resources. (a) Administrative resources. The program shall maintain... assurance, data analysis and reporting, and the holding of hearings and adjudication of cases. A portion of...

  17. 40 CFR 51.354 - Adequate tools and resources.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 40 Protection of Environment 2 2012-07-01 2012-07-01 false Adequate tools and resources. 51.354... Requirements § 51.354 Adequate tools and resources. (a) Administrative resources. The program shall maintain... assurance, data analysis and reporting, and the holding of hearings and adjudication of cases. A portion of...

  18. 40 CFR 51.354 - Adequate tools and resources.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 40 Protection of Environment 2 2013-07-01 2013-07-01 false Adequate tools and resources. 51.354... Requirements § 51.354 Adequate tools and resources. (a) Administrative resources. The program shall maintain... assurance, data analysis and reporting, and the holding of hearings and adjudication of cases. A portion of...

  19. 9 CFR 354.131 - Decomposition.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... CERTIFICATION VOLUNTARY INSPECTION OF RABBITS AND EDIBLE PRODUCTS THEREOF Disposition of Diseased Rabbit Carcasses and Parts § 354.131 Decomposition. Carcasses of rabbits deleteriously affected by post-mortem...

  20. 31 CFR 354.3 - Law governing other interests.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 31 Money and Finance:Treasury 2 2011-07-01 2011-07-01 false Law governing other interests. 354.3... OF THE STUDENT LOAN MARKETING ASSOCIATION (SALLIE MAE) § 354.3 Law governing other interests. (a) To the extent not inconsistent with the regulations in this part, the law (not including the conflict-of...

  1. 9 CFR 354.38 - Suspension of plant approval.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 9 Animals and Animal Products 2 2012-01-01 2012-01-01 false Suspension of plant approval. 354.38... Inspection Service § 354.38 Suspension of plant approval. (a) Any plant approval given pursuant to the regulations in this part may be suspended by the Administrator for: (1) Failure to maintain plant and...

  2. 9 CFR 354.38 - Suspension of plant approval.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 9 Animals and Animal Products 2 2011-01-01 2011-01-01 false Suspension of plant approval. 354.38... Inspection Service § 354.38 Suspension of plant approval. (a) Any plant approval given pursuant to the regulations in this part may be suspended by the Administrator for: (1) Failure to maintain plant and...

  3. 9 CFR 354.38 - Suspension of plant approval.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 9 Animals and Animal Products 2 2013-01-01 2013-01-01 false Suspension of plant approval. 354.38... Inspection Service § 354.38 Suspension of plant approval. (a) Any plant approval given pursuant to the regulations in this part may be suspended by the Administrator for: (1) Failure to maintain plant and...

  4. 9 CFR 354.38 - Suspension of plant approval.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 9 Animals and Animal Products 2 2014-01-01 2014-01-01 false Suspension of plant approval. 354.38... Inspection Service § 354.38 Suspension of plant approval. (a) Any plant approval given pursuant to the regulations in this part may be suspended by the Administrator for: (1) Failure to maintain plant and...

  5. 9 CFR 354.38 - Suspension of plant approval.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 9 Animals and Animal Products 2 2010-01-01 2010-01-01 false Suspension of plant approval. 354.38... Inspection Service § 354.38 Suspension of plant approval. (a) Any plant approval given pursuant to the regulations in this part may be suspended by the Administrator for: (1) Failure to maintain plant and...

  6. 5 CFR 9901.354 - Setting pay upon promotion.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 5 Administrative Personnel 3 2010-01-01 2010-01-01 false Setting pay upon promotion. 9901.354... SECURITY PERSONNEL SYSTEM (NSPS) Pay and Pay Administration Pay Administration § 9901.354 Setting pay upon... salary rate may not be lower than the minimum rate or higher than the maximum rate of the new pay band...

  7. Indicators of Esteem: Gender and Prestige in Academic Work

    ERIC Educational Resources Information Center

    Coate, Kelly; Howson, Camille Kandiko

    2016-01-01

    The continued gender imbalance in senior positions in higher education is a problem that persists despite decades of feminist research and publications in the area, as well as interventions in many countries to promote the advancement of women. In this article we view the issue of gender inequality through the lens of the prestige economy, which…

  8. 9 CFR 354.248 - Scope and applicability of rules of practice.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 9 Animals and Animal Products 2 2010-01-01 2010-01-01 false Scope and applicability of rules of practice. 354.248 Section 354.248 Animals and Animal Products FOOD SAFETY AND INSPECTION SERVICE... Maintenance of Sanitary Conditions and Precautions Against Contamination of Products § 354.248 Scope and...

  9. 9 CFR 354.123 - Segregation of suspects on ante-mortem inspection.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 9 Animals and Animal Products 2 2011-01-01 2011-01-01 false Segregation of suspects on ante-mortem inspection. 354.123 Section 354.123 Animals and Animal Products FOOD SAFETY AND INSPECTION SERVICE... Inspection Procedures; Ante-Mortem Inspections § 354.123 Segregation of suspects on ante-mortem inspection...

  10. 9 CFR 354.123 - Segregation of suspects on ante-mortem inspection.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 9 Animals and Animal Products 2 2010-01-01 2010-01-01 false Segregation of suspects on ante-mortem inspection. 354.123 Section 354.123 Animals and Animal Products FOOD SAFETY AND INSPECTION SERVICE... Inspection Procedures; Ante-Mortem Inspections § 354.123 Segregation of suspects on ante-mortem inspection...

  11. 9 CFR 354.129 - General.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... CERTIFICATION VOLUNTARY INSPECTION OF RABBITS AND EDIBLE PRODUCTS THEREOF Disposition of Diseased Rabbit Carcasses and Parts § 354.129 General. The carcasses or parts of carcasses of all rabbits inspected at an...

  12. 18 CFR 35.4 - Permission to become effective is not approval.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... AND TARIFFS Application § 35.4 Permission to become effective is not approval. The fact that the... 18 Conservation of Power and Water Resources 1 2010-04-01 2010-04-01 false Permission to become effective is not approval. 35.4 Section 35.4 Conservation of Power and Water Resources FEDERAL ENERGY...

  13. 31 CFR 354.5 - Obligations of Sallie Mae; no adverse claims.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ...-ENTRY SECURITIES OF THE STUDENT LOAN MARKETING ASSOCIATION (SALLIE MAE) § 354.5 Obligations of Sallie... a Federal Reserve Bank or otherwise as provided in § 354.4(c)(1), for the purposes of this part 354, Sallie Mae and the Federal Reserve Banks shall treat the Participant to whose Securities Account an...

  14. Sex Differences in the Perceived Dominance and Prestige of Women With and Without Cosmetics.

    PubMed

    Mileva, Viktoria R; Jones, Alex L; Russell, Richard; Little, Anthony C

    2016-10-01

    Women wearing cosmetics have been associated with a higher earning potential and higher status jobs. However, recent literature suggests that status can be accrued through two distinct routes: dominance and prestige. In two experiments, we applied a standardized amount of cosmetics to female faces using computer software. We then asked participants to rate faces with and without cosmetics for various traits including attractiveness, dominance, and prestige. Men and women both rated the faces with cosmetics added as higher in attractiveness. However, only women rated faces with cosmetics as higher in dominance, while only men rated them as higher in prestige. In a follow-up study, we investigated whether these enhanced perceptions of dominance from women were caused by jealousy. We found that women experience more jealousy toward women with cosmetics, and view these women as more attractive to men and more promiscuous. Our findings suggest that cosmetics may function as an extended phenotype and can alter other's perceptions differently depending on the perceiver's sex. © The Author(s) 2016.

  15. Does an aggressor's target choice matter? Assessing change in the social network prestige of aggressive youth.

    PubMed

    Andrews, Naomi C Z; Hanish, Laura D; Santos, Carlos E

    2017-07-01

    Based on a social dominance approach, aggression is conceptualized as a strategy used to gain position, power, and influence within the peer network. However, aggression may only be beneficial when targeted against particular peers; both victims' social standing and the number of victims targeted may impact aggressors' social standing. The current study examined associations between aggressors' targeting tendencies (victims' social standing and number of victims) and aggressors' own social standing, both concurrently and over time. Analyses were conducted using three analytic samples of seventh and eighth grade aggressors (Ns ranged from 161 to 383, 49% girls; 50% Latina/o). Participants nominated their friends; nominations were used to calculate social network prestige. Peer nominations were used to identify aggressors and their victim(s). For each aggressor, number of victims and victims' social network prestige were assessed. Aggressors with more victims and with highly prestigious victims had higher social network prestige themselves, and they increased more in prestige over time than aggressors with fewer victims and less prestigious victims (though there were some differences across analytic samples). Findings have implications for the need to extend the social dominance approach to better address the links between aggressors and victims. Aggr. Behav. 43:364-374, 2017. © 2017 Wiley Periodicals, Inc. © 2017 Wiley Periodicals, Inc.

  16. WAG 2 remedial investigation and site investigation site-specific work plan/health and safety checklist for the soil and sediment task. Environmental Restoration Program

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Holt, V.L.; Burgoa, B.B.

    1993-12-01

    This document is a site-specific work plan/health and safety checklist (WP/HSC) for a task of the Waste Area Grouping 2 Remedial Investigation and Site Investigation (WAG 2 RI&SI). Title 29 CFR Part 1910.120 requires that a health and safety program plan that includes site- and task-specific information be completed to ensure conformance with health- and safety-related requirements. To meet this requirement, the health and safety program plan for each WAG 2 RI&SI field task must include (1) the general health and safety program plan for all WAG 2 RI&SI field activities and (2) a WP/HSC for that particular field task.more » These two components, along with all applicable referenced procedures, must be kept together at the work site and distributed to field personnel as required. The general health and safety program plan is the Health and Safety Plan for the Remedial Investigation and Site Investigation of Waste Area Grouping 2 at the Oak Ridge National Laboratory, Oak Ridge, Tennessee (ORNL/ER-169). The WP/HSCs are being issued as supplements to ORNL/ER-169.« less

  17. Wagging the Dog, Carting the Horse: Testing and Improving Schools. Summary of Conference Proceedings. Research into Practice Project.

    ERIC Educational Resources Information Center

    Herman, Joan; And Others

    The purpose of the conference, "Wagging the Dog, Carting the Horse: Testing vs. Improving California Schools," was to discuss alternative perspectives on testing and evaluation in education and their role in improving teaching and learning. Four papers were presented: (1) "Using Educational Evaluation for the Improvement of California Schools," by…

  18. The effects of a psychosocial dimension of socioeconomic position on survival: occupational prestige and mortality among US working adults

    PubMed Central

    Christ, Sharon L.; Fleming, Lora E.; Lee, David J.; Muntaner, Carles; Muennig, Peter A.; Caban-Martinez, Alberto J.

    2016-01-01

    The association between education or income and mortality has been explored in great detail. These measures capture both the effects of material disadvantage on health and the psychosocial impacts of a low socioeconomic position on health. When explored independently of educational attainment and income, occupational prestige – a purely perceptual measure – serves as a measure of the impact of a psychosocial phenomenon on health. For instance, a fire-fighter, academician or schoolteacher may carry the social benefits of a higher social status without actually having the income (in all cases) or the educational credentials (in the case of the fire-fighter) to match. We explored the independent influence of occupational prestige on mortality. We applied Cox proportional hazards models to a nationally representative sample of over 380,000 US workers who had worked at any time between 1986 and 1994 with mortality follow up through 2002. We found that occupational prestige is associated with a decrease in the risk of all-cause, cancer, cardiovascular and respiratory-related mortality after controlling for household income and educational attainment. We further investigated the question of whether the effects of prestige are moderated by sex and broader occupational groupings. Prestige effects operate in white-collar occupations for men only and within service occupations for all workers. PMID:22443309

  19. Gender Stereotypes of Occupations: Does Women's Work Have Prestige Yet?

    ERIC Educational Resources Information Center

    Girondi, Annette M.; And Others

    While gender stereotyping of occupations has been investigated, the relationship between such stereotypes and job status has received less attention. Two studies were conducted in which assessments of occupational gender stereotyping were compared with assessments of occupational prestige made by the same subjects. In study one, subjects were 20…

  20. Prestige-Oriented Market Entry Strategy: The Case of Australian Universities

    ERIC Educational Resources Information Center

    Tayar, Mark; Jack, Robert

    2013-01-01

    Through an exploratory case study of four Australian universities this article finds that foreign market entry strategies are shaped by prestige-seeking motivations and a culture of risk aversion. From the market selection, entry mode and higher education literature, a conceptual model, embedded with four propositions, is presented. The model sees…

  1. Stability and change in disease prestige: A comparative analysis of three surveys spanning a quarter of a century.

    PubMed

    Album, Dag; Johannessen, Lars E F; Rasmussen, Erik B

    2017-05-01

    In this paper, we present a comparative analysis of three survey studies of disease prestige in medical culture. The studies were conducted in 1990, 2002 and 2014 using the same research design. In each of the three rounds, a sample of Norwegian physicians was asked to rate a set of 38 diseases on a scale from 1 to 9 according to the prestige they believed health personnel in general would award them. The results show a remarkable stability in the prestige rank order over 25 years. The top three diseases in all three surveys were leukaemia, brain tumour and myocardial infarction. The four lowest ranked were fibromyalgia, depressive neurosis, anxiety neurosis and hepatocirrhosis. The most notable change concerns apoplexy (brain stroke), which moved from a rank of 33 to 29 and then to 23 over the three rounds. We argue that the stable pattern, as well as this change, substantiate the interpretation of previous research, i.e. that the prestige of a disease is affected by the localization of the affected organ or body part, the effect and style of its typical treatment, and the social attributes of the typical patient. Analysing physicians' shared evaluations of different diseases, the paper contributes to the cultural understanding of disease conceptions in medicine. Understanding these conceptions is important because disease prestige may influence decision-making in the healthcare sector. Copyright © 2017 Elsevier Ltd. All rights reserved.

  2. 20 CFR 404.354 - Your relationship to the insured.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... Section 404.354 Employees' Benefits SOCIAL SECURITY ADMINISTRATION FEDERAL OLD-AGE, SURVIVORS AND... Disability Child's Benefits § 404.354 Your relationship to the insured. You may be related to the insured person in one of several ways and be entitled to benefits as his or her child, i.e., as a natural child...

  3. 31 CFR 354.9 - Liability of Sallie Mae and Federal Reserve Banks.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... Reserve Banks. 354.9 Section 354.9 Money and Finance: Treasury Regulations Relating to Money and Finance...-ENTRY SECURITIES OF THE STUDENT LOAN MARKETING ASSOCIATION (SALLIE MAE) § 354.9 Liability of Sallie Mae and Federal Reserve Banks. Sallie Mae and the Federal Reserve Banks may rely on the information...

  4. 44 CFR 354.1 - Purpose.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... PREPAREDNESS FEE FOR SERVICES TO SUPPORT FEMA'S OFFSITE RADIOLOGICAL EMERGENCY PREPAREDNESS PROGRAM § 354.1... the amounts that we anticipate to obligate for our Radiological Emergency Preparedness (REP) Program... established in the Treasury a Radiological Emergency Preparedness Fund, to be available under the Atomic...

  5. The Coverage of Campaign Advertising by the Prestige Press in 1972.

    ERIC Educational Resources Information Center

    Bowers, Thomas A.

    The nature and extent of the news media coverage of political advertising in the presidential campaign of 1972 was shallow and spotty at best. The candidates' political advertising strategies received limited coverage by reporters and commentators. Even the "prestige" press--16 major newspapers--provided limited coverage to the nature…

  6. Friendship quality, social preference, proximity prestige, and self-perceived social competence: interactive influences on children's loneliness.

    PubMed

    Zhang, Fengjuan; You, Zhiqi; Fan, Cuiying; Gao, Chuang; Cohen, Robert; Hsueh, Yeh; Zhou, Zongkui

    2014-10-01

    The purpose of this study was to test an integrative model in which peer relations at different levels of social complexity (friendship quality, social preference, and proximity prestige) are associated with children's loneliness, with children's self-perceived social competence acting as a mediator of these associations. A middle childhood sample of 509 Chinese children (233 girls and 276 boys; 3rd to 6th grade) completed a battery of sociometric and self-report questionnaires. Bootstrap analysis showed that self-perceived social competence mediated the relations between each peer variable and loneliness. In the integrative model tested with SEM, the mediating effect of self-perceived social competence in the relation between friendship quality and loneliness and between social preference and loneliness remained significant. However, self-perceived social competence no longer mediated the association between proximity prestige and loneliness, when considering the simultaneous influences of the three peer variables (friendship quality, social preference, and proximity prestige). The whole model accounted for 56% of the variance in loneliness. These findings suggest that self-perceived social competence played an important role in children's loneliness, that the quality and the quantity of direct peer relations (friendship quality, social preference, and part of proximity prestige) were associated with loneliness, and that indirect friends had a relatively lower but significant influence on children's loneliness. The results are discussed in terms of their implications for preventing children's loneliness. Copyright © 2014 Society for the Study of School Psychology. Published by Elsevier Ltd. All rights reserved.

  7. Bacterial Communities from Shoreline Environments (Costa da Morte, Northwestern Spain) Affected by the Prestige Oil Spill▿ †

    PubMed Central

    Alonso-Gutiérrez, Jorge; Figueras, Antonio; Albaigés, Joan; Jiménez, Núria; Viñas, Marc; Solanas, Anna M.; Novoa, Beatriz

    2009-01-01

    The bacterial communities in two different shoreline matrices, rocks and sand, from the Costa da Morte, northwestern Spain, were investigated 12 months after being affected by the Prestige oil spill. Culture-based and culture-independent approaches were used to compare the bacterial diversity present in these environments with that at a nonoiled site. A long-term effect of fuel on the microbial communities in the oiled sand and rock was suggested by the higher proportion of alkane and polyaromatic hydrocarbon (PAH) degraders and the differences in denaturing gradient gel electrophoresis patterns compared with those of the reference site. Members of the classes Alphaproteobacteria and Actinobacteria were the prevailing groups of bacteria detected in both matrices, although the sand bacterial community exhibited higher species richness than the rock bacterial community did. Culture-dependent and -independent approaches suggested that the genus Rhodococcus could play a key role in the in situ degradation of the alkane fraction of the Prestige fuel together with other members of the suborder Corynebacterineae. Moreover, other members of this suborder, such as Mycobacterium spp., together with Sphingomonadaceae bacteria (mainly Lutibacterium anuloederans), were related as well to the degradation of the aromatic fraction of the Prestige fuel. The multiapproach methodology applied in the present study allowed us to assess the complexity of autochthonous microbial communities related to the degradation of heavy fuel from the Prestige and to isolate some of their components for a further physiological study. Since several Corynebacterineae members related to the degradation of alkanes and PAHs were frequently detected in this and other supralittoral environments affected by the Prestige oil spill along the northwestern Spanish coast, the addition of mycolic acids to bioremediation amendments is proposed to favor the presence of these degraders in long-term fuel pollution

  8. 9 CFR 354.132 - Disposal of condemned carcasses and parts.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... parts. 354.132 Section 354.132 Animals and Animal Products FOOD SAFETY AND INSPECTION SERVICE... steam pressure) or thorough cooking in a kettle or vat for a sufficient time to effectively destroy the product for human food purposes and preclude dissemination of disease through consumption by animals...

  9. Isolation of a buprofezin co-metabolizing strain of Pseudomonas sp. DFS35-4 and identification of the buprofezin transformation pathway.

    PubMed

    Chen, Kai; Liu, Xiao-Mei; Li, Rong; Liu, Yuan; Hu, Hai; Li, Shun-Peng; Jiang, Jian-Dong

    2011-11-01

    Buprofezin is a widely used insecticide that has caused environmental pollution in many areas. However, biodegradation of buprofezin by pure cultures has not been extensively studied, and the transformation pathway of buprofezin remains unclear. In this paper, a buprofezin co-metabolizing strain of DFS35-4 was isolated from a buprofezin-polluted soil in China. Strain DFS35-4 was preliminarily identified as Pseudomonas sp. based on its morphological, physiological, and biochemical properties, as well as 16S rRNA gene analysis. In the presence of 2.0 g l(-1) sodium citrate, strain DFS35-4 degraded over 70% of 50 mg l(-1) buprofezin in 3 days. Strain DFS35-4 efficiently degraded buprofezin in the pH range of 5.0-10.0 and at temperatures between 20 and 30°C. Three metabolites, 2-imino-5-phenyl-3-(propan-2-yl)-1,3,5-thiadiazinan-4-one, 2-imino-5-phenyl-1,3,5-thiadiazinan-4-one, and methyl(phenyl) carbamic acid, were identified during the degradation of buprofezin using gas chromatography-mass spectrometry (GC-MS) and tandem mass spectrometry (MS/MS). A partial transformation pathway of buprofezin in Pseudomonas sp. DFS35-4 was proposed based on these metabolites.

  10. English 354: Advanced Composition Writing Ourselves/Communities into Public Conversations

    ERIC Educational Resources Information Center

    Goodburn, Amy; Camp, Heather

    2004-01-01

    English 354: Advanced Composition is a required course for undergraduate majors in English, broadcast journalism, criminal justice, and pre-service English education, among others, at the University of Nebraska-Lincoln, a research-one land-grant institution with a student population of about 24,000. English 354 focuses on "intensive study and…

  11. Age-related changes in albumin elimination in female WAG/Rij rats.

    PubMed Central

    Horbach, G J; Yap, S H; van Bezooijen, C F

    1983-01-01

    Albumin elimination rates were determined in 3-, 12-, 24- and 36-month-old female WAG/Rij rats. No change in elimination half-life was found with age. However, as there was an increase in the whole-body albumin pool, a concomitant increase in albumin clearance was observed at between 12 and 36 months of age. It was concluded that the increase in clearance between 12 and 24 months of age was only due to a change in the animal's physiology, whereas between 24 and 36 months of age it was also due to changes in the albumin molecule. The age-related changes in albumin clearance were thought not to be caused by changes in the albumin excretion via the urine or via the gastrointestinal tract. Images Fig. 1. PMID:6661199

  12. 9 CFR 354.210 - Minimum standards for sanitation, facilities, and operating procedures in official plants.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 9 Animals and Animal Products 2 2012-01-01 2012-01-01 false Minimum standards for sanitation, facilities, and operating procedures in official plants. 354.210 Section 354.210 Animals and Animal Products... sanitation, facilities, and operating procedures in official plants. The provisions of §§ 354.210 to 354.247...

  13. 9 CFR 354.210 - Minimum standards for sanitation, facilities, and operating procedures in official plants.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 9 Animals and Animal Products 2 2011-01-01 2011-01-01 false Minimum standards for sanitation, facilities, and operating procedures in official plants. 354.210 Section 354.210 Animals and Animal Products... sanitation, facilities, and operating procedures in official plants. The provisions of §§ 354.210 to 354.247...

  14. 9 CFR 354.210 - Minimum standards for sanitation, facilities, and operating procedures in official plants.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 9 Animals and Animal Products 2 2014-01-01 2014-01-01 false Minimum standards for sanitation, facilities, and operating procedures in official plants. 354.210 Section 354.210 Animals and Animal Products... sanitation, facilities, and operating procedures in official plants. The provisions of §§ 354.210 to 354.247...

  15. 9 CFR 354.210 - Minimum standards for sanitation, facilities, and operating procedures in official plants.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 9 Animals and Animal Products 2 2010-01-01 2010-01-01 false Minimum standards for sanitation, facilities, and operating procedures in official plants. 354.210 Section 354.210 Animals and Animal Products... sanitation, facilities, and operating procedures in official plants. The provisions of §§ 354.210 to 354.247...

  16. 9 CFR 354.210 - Minimum standards for sanitation, facilities, and operating procedures in official plants.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 9 Animals and Animal Products 2 2013-01-01 2013-01-01 false Minimum standards for sanitation, facilities, and operating procedures in official plants. 354.210 Section 354.210 Animals and Animal Products... sanitation, facilities, and operating procedures in official plants. The provisions of §§ 354.210 to 354.247...

  17. 9 CFR 3.54 - Feeding.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... STANDARDS Specifications for the Humane Handling, Care, Treatment and Transportation of Rabbits Animal Health and Husbandry Standards § 3.54 Feeding. (a) Rabbits shall be fed at least once each day except as... for the condition and size of the rabbit. (b) Food receptacles shall be accessible to all rabbits in a...

  18. 42 CFR 483.354 - General requirements for psychiatric residential treatment facilities.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... treatment facilities. 483.354 Section 483.354 Public Health CENTERS FOR MEDICARE & MEDICAID SERVICES... LONG TERM CARE FACILITIES Condition of Participation for the Use of Restraint or Seclusion in Psychiatric Residential Treatment Facilities Providing Inpatient Psychiatric Services for Individuals Under...

  19. 7 CFR 354.1 - Overtime work at border ports, sea ports, and airports.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 7 Agriculture 5 2011-01-01 2011-01-01 false Overtime work at border ports, sea ports, and airports. 354.1 Section 354.1 Agriculture Regulations of the Department of Agriculture (Continued) ANIMAL AND... EXPORTS; AND USER FEES § 354.1 Overtime work at border ports, sea ports, and airports. (a)(1) Any person...

  20. Vicariously learned helplessness: the role of perceived dominance and prestige of a model.

    PubMed

    Chambers, Sheridan; Hammonds, Frank

    2014-01-01

    Prior research has examined the relationship between various model characteristics (e.g., age, competence, similarity) and the likelihood that the observers will experience vicariously learned helplessness. However, no research in this area has investigated dominance as a relevant model characteristic. This study explored whether the vicarious acquisition of learned helplessness could be mediated by the perceived dominance of a model. Participants observed a model attempting to solve anagrams. Across participant groups, the model displayed either dominant or nondominant characteristics and was either successful or unsuccessful at solving the anagrams. The characteristics displayed by the model significantly affected observers' ratings of his dominance and prestige. After viewing the model, participants attempted to solve 40 anagrams. When the dominant model was successful, observers solved significantly more anagrams than when he was unsuccessful. This effect was not found when the model was nondominant.

  1. The Conundrum of Modern Art : Prestige-Driven Coevolutionary Aesthetics Trumps Evolutionary Aesthetics among Art Experts.

    PubMed

    Verpooten, Jan; Dewitte, Siegfried

    2017-03-01

    Two major mechanisms of aesthetic evolution have been suggested. One focuses on naturally selected preferences (Evolutionary Aesthetics), while the other describes a process of evaluative coevolution whereby preferences coevolve with signals. Signaling theory suggests that expertise moderates these mechanisms. In this article we set out to verify this hypothesis in the domain of art and use it to elucidate Western modern art's deviation from naturally selected preferences. We argue that this deviation is consistent with a Coevolutionary Aesthetics mechanism driven by prestige-biased social learning among art experts. In order to test this hypothesis, we conducted two studies in which we assessed the effects on lay and expert appreciation of both the biological relevance of the given artwork's depicted content, viz., facial beauty, and the prestige specific to the artwork's associated context (MoMA). We found that laypeople appreciate artworks based on their depictions of facial beauty, mediated by aesthetic pleasure, which is consistent with previous studies. In contrast, experts appreciate the artworks based on the prestige of the associated context, mediated by admiration for the artist. Moreover, experts appreciate artworks depicting neutral faces to a greater degree than artworks depicting attractive faces. These findings thus corroborate our contention that expertise moderates the Evolutionary and Coevolutionary Aesthetics mechanisms in the art domain. Furthermore, our findings provide initial support for our proposal that prestige-driven coevolution with expert evaluations plays a decisive role in modern art's deviation from naturally selected preferences. After discussing the limitations of our research as well as the relation that our results bear on cultural evolution theory, we provide a number of suggestions for further research into the potential functions of expert appreciation that deviates from naturally selected preferences, on the one hand, and

  2. Organizational Segmentation and the Prestige Economy: Deprofessionalization in High-and Low-Resource Departments

    ERIC Educational Resources Information Center

    Rosinger, Kelly Ochs; Taylor, Barrett J.; Coco, Lindsay; Slaughter, Sheila

    2015-01-01

    Research often considers vertical stratification between U.S. higher education institutions. Yet differences also exist within higher education institutions, which we term "organizational segmentation." We understand organizational segmentation as a consequence of the external "prestige economy," which favors research revenues…

  3. 31 CFR 354.4 - Creation of Participant's Security Entitlement; security interests.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 31 Money and Finance: Treasury 2 2010-07-01 2010-07-01 false Creation of Participant's Security Entitlement; security interests. 354.4 Section 354.4 Money and Finance: Treasury Regulations Relating to Money... Creation of Participant's Security Entitlement; security interests. (a) A Participant's Security...

  4. 31 CFR 354.4 - Creation of Participant's Security Entitlement; security interests.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 31 Money and Finance:Treasury 2 2012-07-01 2012-07-01 false Creation of Participant's Security Entitlement; security interests. 354.4 Section 354.4 Money and Finance: Treasury Regulations Relating to Money... Creation of Participant's Security Entitlement; security interests. (a) A Participant's Security...

  5. 31 CFR 354.4 - Creation of Participant's Security Entitlement; security interests.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 31 Money and Finance: Treasury 2 2014-07-01 2014-07-01 false Creation of Participant's Security Entitlement; security interests. 354.4 Section 354.4 Money and Finance: Treasury Regulations Relating to Money... Creation of Participant's Security Entitlement; security interests. (a) A Participant's Security...

  6. 31 CFR 354.4 - Creation of Participant's Security Entitlement; security interests.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 31 Money and Finance:Treasury 2 2011-07-01 2011-07-01 false Creation of Participant's Security Entitlement; security interests. 354.4 Section 354.4 Money and Finance: Treasury Regulations Relating to Money... Creation of Participant's Security Entitlement; security interests. (a) A Participant's Security...

  7. 31 CFR 354.4 - Creation of Participant's Security Entitlement; security interests.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 31 Money and Finance:Treasury 2 2013-07-01 2013-07-01 false Creation of Participant's Security Entitlement; security interests. 354.4 Section 354.4 Money and Finance: Treasury Regulations Relating to Money... Creation of Participant's Security Entitlement; security interests. (a) A Participant's Security...

  8. 9 CFR 354.46 - Misrepresentation; deceptive or fraudulent acts or practices.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 9 Animals and Animal Products 2 2011-01-01 2011-01-01 false Misrepresentation; deceptive or fraudulent acts or practices. 354.46 Section 354.46 Animals and Animal Products FOOD SAFETY AND INSPECTION... issue or use any inspection certificate, symbol, stamp, label, seal or identification, authorized...

  9. 9 CFR 354.46 - Misrepresentation; deceptive or fraudulent acts or practices.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 9 Animals and Animal Products 2 2010-01-01 2010-01-01 false Misrepresentation; deceptive or fraudulent acts or practices. 354.46 Section 354.46 Animals and Animal Products FOOD SAFETY AND INSPECTION... issue or use any inspection certificate, symbol, stamp, label, seal or identification, authorized...

  10. Winning Is Everything: The Intersection of Academics and Athletics at Prestige University

    ERIC Educational Resources Information Center

    Clayton, Ashley B.; Grantham, Ashley; McGurrin, Daniel P.; Paparella, Paul; Pellegrino, Lauren N.

    2015-01-01

    For years, football and basketball players at Prestige University were earning college credit for classes that never existed. The students were enrolled in fake courses, known as "ghost classes," with no formal instruction or required meeting times and requiring only a single term paper. Faculty, staff, and administrators were complicit…

  11. Antinociceptive synergism of MD-354 and clonidine. Part II. The alpha-adrenoceptor component.

    PubMed

    Young, Shawquia; Vainio, Minna; Scheinin, Mika; Dukat, Małgorzata

    2010-08-01

    Previously, we reported that antinociceptive synergism of a 5-HT(3)/alpha(2)-adrenoceptor ligand MD-354 (m-chlorophenylguanidine) and clonidine combination occurs, in part, through a 5-HT(3) receptor antagonist mechanism. In the present investigation, a possible role for alpha(2)-adrenoceptors was examined. Mechanistic studies using yohimbine (a subtype non-selective alpha(2)-adrenoceptor antagonist), BRL 44408 (a preferential alpha(2A)-adrenoceptor antagonist) and imiloxan (a preferential alpha(2B/C)-adrenoceptor antagonist) on the antinociceptive actions of a MD-354/clonidine combination were conducted. Subcutaneous pre-treatment with all three antagonists inhibited the antinociceptive synergism of MD-354 and clonidine in the mouse tail-flick assay in a dose-dependent manner (AD(50) = 0.33, 2.1, and 0.17 mg/kg, respectively). Enhancement of clonidine antinociception by MD-354 did not potentiate clonidine's locomotor suppressant activity in a mouse locomotor assay. When [ethyl-3H]RS-79948-197 was used as radioligand, MD-354 displayed almost equal affinity to alpha(2A)- and alpha(2B)-adrenoceptors (K(i) = 110 and 220 nM) and showed lower affinity at alpha(2C)-adrenoceptors (K(i) = 4,700 nM). MD-354 had no subtype-selectivity for the alpha(2)-adrenoceptor subtypes as an antagonist in functional [35S]GTPgammaS binding assays. MD-354 was a weak partial agonist at alpha(2A)-adrenoceptors. Overall, in addition to the 5-HT(3) receptor component, the present investigation found MD-354 to be a weak partial alpha(2A)-adrenoceptor agonist that enhances clonidine's thermal antinociceptive actions through an alpha(2)-adrenoceptor-mediated mechanism without augmenting sedation.

  12. 7 CFR 3565.354 - Fair housing accommodations.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ..., DEPARTMENT OF AGRICULTURE GUARANTEED RURAL RENTAL HOUSING PROGRAM Project Management § 3565.354 Fair housing... in the development of the property, the selection of applicants for housing, and ongoing management...

  13. 7 CFR 3565.354 - Fair housing accommodations.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ..., DEPARTMENT OF AGRICULTURE GUARANTEED RURAL RENTAL HOUSING PROGRAM Project Management § 3565.354 Fair housing... in the development of the property, the selection of applicants for housing, and ongoing management...

  14. 7 CFR 3565.354 - Fair housing accommodations.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ..., DEPARTMENT OF AGRICULTURE GUARANTEED RURAL RENTAL HOUSING PROGRAM Project Management § 3565.354 Fair housing... in the development of the property, the selection of applicants for housing, and ongoing management...

  15. 7 CFR 3565.354 - Fair housing accommodations.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ..., DEPARTMENT OF AGRICULTURE GUARANTEED RURAL RENTAL HOUSING PROGRAM Project Management § 3565.354 Fair housing... in the development of the property, the selection of applicants for housing, and ongoing management...

  16. 7 CFR 3565.354 - Fair housing accommodations.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ..., DEPARTMENT OF AGRICULTURE GUARANTEED RURAL RENTAL HOUSING PROGRAM Project Management § 3565.354 Fair housing... in the development of the property, the selection of applicants for housing, and ongoing management...

  17. The evolution of prestige: freely conferred deference as a mechanism for enhancing the benefits of cultural transmission.

    PubMed

    Henrich, J; Gil-White, F J.

    2001-05-01

    This paper advances an "information goods" theory that explains prestige processes as an emergent product of psychological adaptations that evolved to improve the quality of information acquired via cultural transmission. Natural selection favored social learners who could evaluate potential models and copy the most successful among them. In order to improve the fidelity and comprehensiveness of such ranked-biased copying, social learners further evolved dispositions to sycophantically ingratiate themselves with their chosen models, so as to gain close proximity to, and prolonged interaction with, these models. Once common, these dispositions created, at the group level, distributions of deference that new entrants may adaptively exploit to decide who to begin copying. This generated a preference for models who seem generally "popular." Building on social exchange theories, we argue that a wider range of phenomena associated with prestige processes can more plausibly be explained by this simple theory than by others, and we test its predictions with data from throughout the social sciences. In addition, we distinguish carefully between dominance (force or force threat) and prestige (freely conferred deference).

  18. Specialty Choice Among Sexual and Gender Minorities in Medicine: The Role of Specialty Prestige, Perceived Inclusion, and Medical School Climate.

    PubMed

    Sitkin, Nicole A; Pachankis, John E

    2016-12-01

    Sexual and gender minorities (SGMs) in medicine experience unique stressors in training. However, little is known about SGM specialty choice. This study examined predictors of SGM specialty choice, associations between specialty prestige and perceived SGM inclusion, and self-reported influences on specialty choice. Medical trainees and practitioners (358 SGM, 1528 non-SGM) were surveyed online. We operationalized specialty choice at the individual level as respondents' specialty of practice; at the specialty level, as a percentage of SGM respondents in each specialty. We examined specialty prestige, perceived SGM inclusivity, and medical school climate as predictors of SGM specialty choice, and we compared additional influences on specialty choice between SGM and non-SGM. The percentage of SGM in each specialty was inversely related to specialty prestige (P = 0.001) and positively related to perceived SGM inclusivity (P = 0.01). Prestigious specialties were perceived as less SGM inclusive (P < 0.001). Medical school climate did not predict specialty prestige (P = 0.82). SGM were more likely than non-SGM to indicate that sexual and gender identity strongly influenced specialty choice (P < 0.01). SGM most frequently rated personality fit, specialty content, role models, and work-life balance as strong influences on specialty choice. Exposure as a medical student to SGM faculty did not predict specialty prestige among SGM. Specialty prestige and perceived inclusivity predict SGM specialty choice. SGM diversity initiatives in prestigious specialties may be particularly effective by addressing SGM inclusion directly. Further research is needed to inform effective mentorship for SGM medical students. Exposure to SGM in medical training reduces anti-SGM bias among medical professionals, and SGM in medicine often assume leadership roles in clinical care, education, and research regarding SGM health. Supporting and promoting SGM diversity across the

  19. Specialty Choice Among Sexual and Gender Minorities in Medicine: The Role of Specialty Prestige, Perceived Inclusion, and Medical School Climate

    PubMed Central

    Pachankis, John E.

    2016-01-01

    Abstract Purpose: Sexual and gender minorities (SGMs) in medicine experience unique stressors in training. However, little is known about SGM specialty choice. This study examined predictors of SGM specialty choice, associations between specialty prestige and perceived SGM inclusion, and self-reported influences on specialty choice. Methods: Medical trainees and practitioners (358 SGM, 1528 non-SGM) were surveyed online. We operationalized specialty choice at the individual level as respondents' specialty of practice; at the specialty level, as a percentage of SGM respondents in each specialty. We examined specialty prestige, perceived SGM inclusivity, and medical school climate as predictors of SGM specialty choice, and we compared additional influences on specialty choice between SGM and non-SGM. Results: The percentage of SGM in each specialty was inversely related to specialty prestige (P = 0.001) and positively related to perceived SGM inclusivity (P = 0.01). Prestigious specialties were perceived as less SGM inclusive (P < 0.001). Medical school climate did not predict specialty prestige (P = 0.82). SGM were more likely than non-SGM to indicate that sexual and gender identity strongly influenced specialty choice (P < 0.01). SGM most frequently rated personality fit, specialty content, role models, and work–life balance as strong influences on specialty choice. Exposure as a medical student to SGM faculty did not predict specialty prestige among SGM. Conclusion: Specialty prestige and perceived inclusivity predict SGM specialty choice. SGM diversity initiatives in prestigious specialties may be particularly effective by addressing SGM inclusion directly. Further research is needed to inform effective mentorship for SGM medical students. Exposure to SGM in medical training reduces anti-SGM bias among medical professionals, and SGM in medicine often assume leadership roles in clinical care, education, and research regarding SGM health

  20. 9 CFR 354.226 - Lighting and ventilation.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... INSPECTION AND CERTIFICATION VOLUNTARY INSPECTION OF RABBITS AND EDIBLE PRODUCTS THEREOF Buildings and Plant Facilities § 354.226 Lighting and ventilation. There shall be ample light, either natural or artificial or...

  1. 9 CFR 354.25 - Political activity.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... ORGANIZATION AND TERMINOLOGY; MANDATORY MEAT AND POULTRY PRODUCTS INSPECTION AND VOLUNTARY INSPECTION AND CERTIFICATION VOLUNTARY INSPECTION OF RABBITS AND EDIBLE PRODUCTS THEREOF Performance of Services § 354.25... licenses, to take an active part in political management or in political campaigns. Political activity in...

  2. 9 CFR 354.25 - Political activity.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... ORGANIZATION AND TERMINOLOGY; MANDATORY MEAT AND POULTRY PRODUCTS INSPECTION AND VOLUNTARY INSPECTION AND CERTIFICATION VOLUNTARY INSPECTION OF RABBITS AND EDIBLE PRODUCTS THEREOF Performance of Services § 354.25... licenses, to take an active part in political management or in political campaigns. Political activity in...

  3. 9 CFR 354.25 - Political activity.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... ORGANIZATION AND TERMINOLOGY; MANDATORY MEAT AND POULTRY PRODUCTS INSPECTION AND VOLUNTARY INSPECTION AND CERTIFICATION VOLUNTARY INSPECTION OF RABBITS AND EDIBLE PRODUCTS THEREOF Performance of Services § 354.25... licenses, to take an active part in political management or in political campaigns. Political activity in...

  4. 9 CFR 354.25 - Political activity.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... ORGANIZATION AND TERMINOLOGY; MANDATORY MEAT AND POULTRY PRODUCTS INSPECTION AND VOLUNTARY INSPECTION AND CERTIFICATION VOLUNTARY INSPECTION OF RABBITS AND EDIBLE PRODUCTS THEREOF Performance of Services § 354.25... licenses, to take an active part in political management or in political campaigns. Political activity in...

  5. 9 CFR 354.25 - Political activity.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... ORGANIZATION AND TERMINOLOGY; MANDATORY MEAT AND POULTRY PRODUCTS INSPECTION AND VOLUNTARY INSPECTION AND CERTIFICATION VOLUNTARY INSPECTION OF RABBITS AND EDIBLE PRODUCTS THEREOF Performance of Services § 354.25... licenses, to take an active part in political management or in political campaigns. Political activity in...

  6. In vivo genotoxicity assessment in rats exposed to Prestige-like oil by inhalation.

    PubMed

    Valdiglesias, Vanessa; Kiliç, Gözde; Costa, Carla; Amor-Carro, Óscar; Mariñas-Pardo, Luis; Ramos-Barbón, David; Méndez, Josefina; Pásaro, Eduardo; Laffon, Blanca

    2012-01-01

    One of the largest oil spill disasters in recent times was the accident of the oil tanker Prestige in front of the Galician coast in 2002. Thousands of people participated in the cleanup of the contaminated areas, being exposed to a complex mixture of toxic substances. Acute and prolonged respiratory symptoms and genotoxic effects were reported, although environmental exposure measurements were restricted to current determinations, such that attribution of effects observed to oil exposure is difficult to establish. The aim of this study was to analyze peripheral blood leukocytes (PBL) harvested from a rat model of subchronic exposure to a fuel oil with similar characteristics to that spilled by the Prestige tanker, in order to determine potential genotoxic effects under strictly controlled, in vivo exposure. Wistar Han and Brown Norway rats were exposed to the oil for 3 wk, and micronucleus test (MN) and comet assay, standard and modified with 8-oxoguanine DNA glycosylase (OGG1) enzyme, were employed to assess genotoxicity 72 h and 15 d after the last exposure. In addition, the potential effects of oil exposure on DNA repair capacity were determined by means of mutagen sensitivity assay. Results obtained from this study showed that inhalation oil exposure induced DNA damage in both Brown Norway and Wistar Han rats, especially in those animals evaluated 15 d after exposure. Although alterations in the DNA repair responses were noted, the sensitivity to oil substances varied depending on rat strain. Data support previous positive genotoxicity results reported in humans exposed to Prestige oil during cleanup tasks.

  7. 9 CFR 354.142 - Food product inspection certificates; issuance and disposition.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 9 Animals and Animal Products 2 2010-01-01 2010-01-01 false Food product inspection certificates; issuance and disposition. 354.142 Section 354.142 Animals and Animal Products FOOD SAFETY AND INSPECTION SERVICE, DEPARTMENT OF AGRICULTURE AGENCY ORGANIZATION AND TERMINOLOGY; MANDATORY MEAT AND POULTRY PRODUCTS INSPECTION AND VOLUNTARY INSPECTION...

  8. 38 CFR 3.54 - Marriage dates.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ..., Compensation, and Dependency and Indemnity Compensation Relationship § 3.54 Marriage dates. A surviving spouse may qualify for pension, compensation, or dependency and indemnity compensation if the marriage to the... was born to them before the marriage. (Authority: 38 U.S.C. 1102) (c) Dependency and indemnity...

  9. 38 CFR 3.54 - Marriage dates.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ..., Compensation, and Dependency and Indemnity Compensation Relationship § 3.54 Marriage dates. A surviving spouse may qualify for pension, compensation, or dependency and indemnity compensation if the marriage to the... was born to them before the marriage. (Authority: 38 U.S.C. 1102) (c) Dependency and indemnity...

  10. 38 CFR 3.54 - Marriage dates.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ..., Compensation, and Dependency and Indemnity Compensation Relationship § 3.54 Marriage dates. A surviving spouse may qualify for pension, compensation, or dependency and indemnity compensation if the marriage to the... was born to them before the marriage. (Authority: 38 U.S.C. 1102) (c) Dependency and indemnity...

  11. 46 CFR 153.354 - Venting system inlet.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... BULK LIQUID, LIQUEFIED GAS, OR COMPRESSED GAS HAZARDOUS MATERIALS Design and Equipment Cargo Venting Systems § 153.354 Venting system inlet. A venting system must terminate in the vapor space above the cargo...

  12. 46 CFR 153.354 - Venting system inlet.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... BULK LIQUID, LIQUEFIED GAS, OR COMPRESSED GAS HAZARDOUS MATERIALS Design and Equipment Cargo Venting Systems § 153.354 Venting system inlet. A venting system must terminate in the vapor space above the cargo...

  13. 46 CFR 153.354 - Venting system inlet.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... BULK LIQUID, LIQUEFIED GAS, OR COMPRESSED GAS HAZARDOUS MATERIALS Design and Equipment Cargo Venting Systems § 153.354 Venting system inlet. A venting system must terminate in the vapor space above the cargo...

  14. 46 CFR 153.354 - Venting system inlet.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... BULK LIQUID, LIQUEFIED GAS, OR COMPRESSED GAS HAZARDOUS MATERIALS Design and Equipment Cargo Venting Systems § 153.354 Venting system inlet. A venting system must terminate in the vapor space above the cargo...

  15. 46 CFR 153.354 - Venting system inlet.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... BULK LIQUID, LIQUEFIED GAS, OR COMPRESSED GAS HAZARDOUS MATERIALS Design and Equipment Cargo Venting Systems § 153.354 Venting system inlet. A venting system must terminate in the vapor space above the cargo...

  16. Modernity, Prestige, and Self-Promotion: Literacy in a Papua New Guinean Community

    ERIC Educational Resources Information Center

    McKeown, Eamonn

    2006-01-01

    In this article, I examine patterns of literacy use in the daily life a rural community in the Papua New Guinea highlands. It is demonstrated that many of these practices do not correspond to the ways in which agencies responsible for imparting literacy, particularly the local school, intend. Instead, village concepts of prestige, chance, and…

  17. Prestige from the Bottom Up: A Review of Language Planning in Guernsey

    ERIC Educational Resources Information Center

    Sallabank, Julia

    2005-01-01

    This paper discusses language planning measures in Guernsey, Channel Islands. The indigenous language is spoken fluently by only 2% of the population, and is at level 7 on Fishman's 8-point scale of endangerment. It has no official status and low social prestige, and language planning has little official support or funding. Political autonomy has…

  18. Evolutionary Thinking in Microeconomic Models: Prestige Bias and Market Bubbles

    PubMed Central

    Bell, Adrian Viliami

    2013-01-01

    Evolutionary models broadly support a number of social learning strategies likely important in economic behavior. Using a simple model of price dynamics, I show how prestige bias, or copying of famed (and likely successful) individuals, influences price equilibria and investor disposition in a way that exacerbates or creates market bubbles. I discuss how integrating the social learning and demographic forces important in cultural evolution with economic models provides a fruitful line of inquiry into real-world behavior. PMID:23544100

  19. Autophagy inhibition sensitizes WYE-354-induced anti-colon cancer activity in vitro and in vivo.

    PubMed

    Wang, Lijun; Zhu, Yun-Rong; Wang, Shaowei; Zhao, Song

    2016-09-01

    Mammalian target of rapamycin (mTOR) complex 1 (mTORC1) and mTORC2 are frequently dysregulated in human colon cancers. In the present study, we evaluated the potential anti-colon cancer cell activity by a novel mTORC1/2 dual inhibitor WYE-354. We showed that WYE-354 was anti-survival and anti-proliferative when adding to primary (patient-derived) and established (HCT-116, HT-29, Caco-2, LoVo, and DLD-1 lines) colon cancer cells. In addition, WYE-354 treatment activated caspase-dependent apoptosis in the colon cancer cells. Mechanistically, WYE-354 blocked mTORC1 and mTORC2 activation. Meanwhile, it also induced autophagy activation in the colon cancer cells. Autophagy inhibitors (bafilomycin A1 and 3-methyladenine), or shRNA-mediated knockdown of autophagy elements (Beclin-1 and ATG-5), remarkably sensitized WYE-354-mediated anti-colon cancer cell activity in vitro. Further studies showed that WYE-354 administration inhibited HT-29 xenograft growth in severe combined immunodeficient (SCID) mice. Importantly, its activity in vivo was further potentiated with co-administration of the autophagy inhibitor 3-MA. Phosphorylations of Akt (Ser-473) and S6 were also decreased in WYE-354-treated HT-29 xenografts. Together, these pre-clinical results demonstrate the potent anti-colon cancer cell activity by WYE-354, and its activity may be further augmented with autophagy inhibition.

  20. 47 CFR 36.354 - Access expenses-Account 6540.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... JURISDICTIONAL SEPARATIONS PROCEDURES; STANDARD PROCEDURES FOR SEPARATING TELECOMMUNICATIONS PROPERTY COSTS... Network Operations Expenses § 36.354 Access expenses—Account 6540. (a) This account includes access...

  1. 9 CFR 354.232 - Restrictions on use.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 354.232 Animals and Animal Products FOOD SAFETY AND INSPECTION SERVICE, DEPARTMENT OF AGRICULTURE... food) from inedible material shall not be used outside of the inedible products department except under... Conditions and Precautions Against Contamination of Products ...

  2. Pursuing Prestige in Higher Education: Stratification, Status, and the Influence of College Ranking

    ERIC Educational Resources Information Center

    Ortagus, Justin C.

    2016-01-01

    Research has suggested that changes in rankings have an impact on admissions outcomes at colleges and universities. This study incorporates organization theory to explain these mechanisms and other external forces driving the pursuit of prestige in higher education. Beyond updating and replicating previous findings related to the impact of college…

  3. 42 CFR 405.354 - Procedures for adjustment or recovery-title II beneficiary.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 42 Public Health 2 2011-10-01 2011-10-01 false Procedures for adjustment or recovery-title II beneficiary. 405.354 Section 405.354 Public Health CENTERS FOR MEDICARE & MEDICAID SERVICES, DEPARTMENT OF HEALTH AND HUMAN SERVICES MEDICARE PROGRAM FEDERAL HEALTH INSURANCE FOR THE AGED AND DISABLED Suspension...

  4. 42 CFR 405.354 - Procedures for adjustment or recovery-title II beneficiary.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 42 Public Health 2 2010-10-01 2010-10-01 false Procedures for adjustment or recovery-title II beneficiary. 405.354 Section 405.354 Public Health CENTERS FOR MEDICARE & MEDICAID SERVICES, DEPARTMENT OF HEALTH AND HUMAN SERVICES MEDICARE PROGRAM FEDERAL HEALTH INSURANCE FOR THE AGED AND DISABLED Suspension...

  5. 34 CFR 35.4 - Administrative claim; evidence and information to be submitted.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 34 Education 1 2010-07-01 2010-07-01 false Administrative claim; evidence and information to be submitted. 35.4 Section 35.4 Education Office of the Secretary, Department of Education TORT CLAIMS AGAINST... bills for medical, dental, and hospital expenses incurred, or itemized receipts of payment for such...

  6. 34 CFR 35.4 - Administrative claim; evidence and information to be submitted.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 34 Education 1 2011-07-01 2011-07-01 false Administrative claim; evidence and information to be submitted. 35.4 Section 35.4 Education Office of the Secretary, Department of Education TORT CLAIMS AGAINST... bills for medical, dental, and hospital expenses incurred, or itemized receipts of payment for such...

  7. Globalization and Food Prestige among Indian Adolescents.

    PubMed

    Maxfield, Amanda; Patil, Shailaja; Cunningham, Solveig A

    2016-01-01

    This study provides a foundation for understanding how globalization and changing food environments are linked to cultural models of food prestige in adolescents. We used methods from cognitive anthropology, including free lists, pile sorts, and consensus modeling, to explore the meanings that Indian adolescents attribute to foods. Adolescents (n = 29) were asked to free list foods eaten outside and inside the home. Different adolescents (n = 65) were asked to pile sort and rank 30 foods identified during the free lists according to which foods are the most prestigious, traditional, routine, and advertised on television. We found that adolescents overwhelmingly believed nontraditional foods to be the most prestigious. Nonlocal foods, both from foreign countries and other regions of India, as well as foods eaten outside the home, were also considered prestigious.

  8. What Young Students in a Major Industrial City Think about the Prestige of Professions

    ERIC Educational Resources Information Center

    Kaiumov, A. T.; Kanikov, F. K.; Iskhakova, N. R.

    2014-01-01

    Research on factors affecting the prestige of engineering and blue-collar occupations in Russia shows that, in addition to such things as intrinsic interest and expected income, young people's views are influenced by the kinds of people who typically go into various kinds of occupation.

  9. What Motivates Us for Work? Intricate Web of Factors beyond Money and Prestige.

    PubMed

    Damij, Nadja; Levnajić, Zoran; Rejec Skrt, Vesna; Suklan, Jana

    2015-01-01

    Efficiency at doing a certain task, at the workplace or otherwise, is strongly influenced by how motivated individuals are. Exploring new ways to motivate employees is often at the top of a company's agenda. Traditionally identified motivators in Western economies primarily include salary and prestige, often complemented by meaning, creation, challenge, ownership, identity, etc. We report the results of a survey conducted in Slovenia, involving an ensemble of highly educated employees from various public and private organizations. Employing new methodologies such as network analysis, we find that Slovenians are stimulated by an intricate web of interdependent factors, largely in contrast to the traditional understanding that mainly emphasizes money and prestige. In fact, these key motivators only weakly correlate with the demographic parameters. Unexpectedly, we found the evidence of a general optimism in Slovenian professional life - a tendency of the employees to look at the "bright side of things", thus seeing more clearly the benefits of having something than the drawbacks of not having it. We attribute these particularities to Slovenian recent history, which revolves around gradually embracing the Western (economic) values.

  10. 44 CFR 354.4 - Assessment of fees.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... HOMELAND SECURITY PREPAREDNESS FEE FOR SERVICES TO SUPPORT FEMA'S OFFSITE RADIOLOGICAL EMERGENCY... CFR 50.54(q) requirements stating that offsite radiological emergency planning and preparedness are no... 44 Emergency Management and Assistance 1 2010-10-01 2010-10-01 false Assessment of fees. 354.4...

  11. Prestige Planning and the Welsh Language: Marketing, the Consumer-Citizen and Language Behaviour

    ERIC Educational Resources Information Center

    Chriost, Diarmait Mac Giolla

    2006-01-01

    This paper comprises a brief examination of the approach taken by the Welsh Language Board, as the principal language policy and planning body in Wales, with regard to aspects of prestige planning and the Welsh language. It describes how devolution and the recent, and first ever, national review by the Welsh Assembly Government of Welsh language…

  12. Gender and Prestige in Swedish Academia: Exploring Senior Management in Universities and University Colleges

    ERIC Educational Resources Information Center

    Peterson, Helen

    2017-01-01

    This article highlights the multifaceted character of the Swedish higher education sector and investigates senior academic management positions from a gender perspective using theories about an academic prestige economy and academic capitalism. The focus is on an aspect often overseen in research on Swedish academia: the distinction between…

  13. Experimenter Prestige and Feedback Related to Acceptance of Genuine Personality Interpretations and Self-Attitude

    ERIC Educational Resources Information Center

    Bradley, Gifford W.; Bradley, Laurence A.

    1977-01-01

    It was found that (a) subjects in all conditions rated the interpretations as being fairly accurate descriptions of their personalities; (b) the acceptance of the feedback did not vary as a function of experimenter prestige; and (c) receiving personality feedback had no effects on subjects' self-attitudes. (Author/MV)

  14. Publications - GMC 354 | Alaska Division of Geological & Geophysical

    Science.gov Websites

    DGGS GMC 354 Publication Details Title: XRF Analyses of Husky Oil NPR Operations Inc U.S. Geological Statewide Bibliographic Reference Advanced Instrumentation Laboratory, 2008, XRF Analyses of Husky Oil NPR

  15. Institutional Stratification and the Postcollege Labor Market: Comparing Job Satisfaction and Prestige across Generations

    ERIC Educational Resources Information Center

    Kim, Jeongeun; Kim, Jiyun; Jaquette, Ozan; Bastedo, Michael N.

    2014-01-01

    Employing NCES databases, we investigate how college selectivity influences job satisfaction and prestige from the 1970s to the 1990s and across different racial categories. We find that the effect of college selectivity has essentially disappeared over time and that minority students are particularly disadvantaged with respect to job satisfaction.

  16. Planning for Preeminence: Perceptions of Prestige in Catholic Universities of the Western United States

    ERIC Educational Resources Information Center

    Cifone, Rocco John

    2013-01-01

    The purpose of this study was to determine what effect the perception of an institution's prestige has on strategic planning undertaken by American Catholic colleges and universities and whether these schools engage in purposeful and effective positioning of themselves in the market. The study considered efforts to achieve preeminence amongst…

  17. 9 CFR 354.121 - Ante-mortem inspection.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... he may issue from time to time, be made of rabbits on the day of slaughter in any official plant... INSPECTION AND CERTIFICATION VOLUNTARY INSPECTION OF RABBITS AND EDIBLE PRODUCTS THEREOF Inspection Procedures; Ante-Mortem Inspections § 354.121 Ante-mortem inspection. An ante-mortem inspection of rabbits...

  18. 9 CFR 354.121 - Ante-mortem inspection.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... he may issue from time to time, be made of rabbits on the day of slaughter in any official plant... INSPECTION AND CERTIFICATION VOLUNTARY INSPECTION OF RABBITS AND EDIBLE PRODUCTS THEREOF Inspection Procedures; Ante-Mortem Inspections § 354.121 Ante-mortem inspection. An ante-mortem inspection of rabbits...

  19. 38 CFR 3.354 - Determinations of insanity.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ....354 Determinations of insanity. (a) Definition of insanity. An insane person is one who, while not... behavior; or who interferes with the peace of society; or who has so departed (become antisocial) from the... the definition in paragraph (a) of this section. [26 FR 1589, Feb. 24, 1961] ...

  20. 9 CFR 354.230 - Equipment and utensils.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... Section 354.230 Animals and Animal Products FOOD SAFETY AND INSPECTION SERVICE, DEPARTMENT OF AGRICULTURE... equipped with facilities for locking and sealing. (m) Freezing rooms should be adequately equipped to... constant as possible. Freezing room should be equipped with floor racks or pallets and fans to insure air...

  1. [Serum levels of antibodies for IgG, IgA, and IgM against the fungi antigen in psoriasis vulgaris].

    PubMed

    Liang, Yun-sheng; Wen, Hai-quan; Xiao, Rong

    2003-12-01

    To detect the serum levels of antibodies against Malassezia further and Candida albicans in patients with psoriasis vulgaris (PV), and to investigate the relationship between Malassezia furfur or Candida albicans and pathogenesis of PV. The serum levels of antibodies for IgG, IgA, and IgM against the whole cell antigen Wag and soluble antigen (Sag) of Malassezia fufur and Candida albicans in 40 PV patients and 20 healthy controls were detected by indirect-ELISA, RESULTS: The serum levels of IgG against Wag of Malassezia furfur and Candida albicans were significantly higher in PV patients than those in the healthy controls (P < 0.01, P < 0.05, respectively), The serum levels of IgM against Sag of Malassezia furfur and Candida albican, IgA against Sag of Candida albicans were significantly lower in PV patients than those in the healthy controls (P < 0.05). There are some humoral immunity abnormalties in PV patients. Malassezia furfur and Candida albicans may be related to the pathogenesis of PV.

  2. Torsion-wagging tunneling and vibrational states in hydrazine determined from its ab initio potential energy surface

    NASA Astrophysics Data System (ADS)

    Łodyga, Wiesław; Makarewicz, Jan

    2012-05-01

    Geometries, anharmonic vibrations, and torsion-wagging (TW) multiplets of hydrazine and its deuterated species are studied using high-level ab initio methods employing the second-order Møller-Plesset perturbation theory (MP2) as well as the coupled cluster singles and doubles model including connected triple corrections, CCSD(T), in conjunction with extended basis sets containing diffuse and core functions. To describe the splitting patterns caused by tunneling in TW states, the 3D potential energy surface (PES) for the large-amplitude TW modes is constructed. Stationary points in the 3D PES, including equivalent local minima and saddle points are characterized. Using this 3D PES, a flexible Hamiltonian is built numerically and then employed to solve the vibrational problem for TW coupled motion. The calculated ground state rav structure is expected to be more reliable than the experimental one that has been determined using a simplified structural model. The calculated fundamental frequencies allowed resolution of the assignment problems discussed earlier in the literature. The determined energy barriers, including the contributions from the small-amplitude vibrations, to the tunneling of the symmetric and antisymmetric wagging mode of 1997 cm-1 and 3454 cm-1, respectively, are in reasonable agreement with the empirical estimates of 2072 cm-1 and 3312 cm-1, respectively [W. Łodyga et al. J. Mol. Spectrosc. 183, 374 (1997), 10.1006/jmsp.1997.7271]. However, the empirical torsion barrier of 934 cm-1 appears to be overestimated. The ab initio calculations yield two torsion barriers: cis and trans of 744 cm-1 and 2706 cm-1, respectively. The multiplets of the excited torsion states are predicted from the refined 3D PES.

  3. The downfall of TBA-354 - a possible explanation for its neurotoxicity via mass spectrometric imaging.

    PubMed

    Ntshangase, Sphamandla; Shobo, Adeola; Kruger, Hendrik G; Asperger, Arndt; Niemeyer, Dagmar; Arvidsson, Per I; Govender, Thavendran; Baijnath, Sooraj

    2017-10-13

    1. TBA-354 was a promising antitubercular compound with activity against both replicating and static Mycobacterium tuberculosis (M.tb), making it the focal point of many clinical trials conducted by the TB Alliance. However, findings from these trials have shown that TBA-354 results in mild signs of reversible neurotoxicity; this left the TB Alliance with no other choice but to stop the research. 2. In this study, mass spectrometric methods were used to evaluate the pharmacokinetics and spatial distribution of TBA-354 in the brain using a validated liquid chromatography tandem-mass spectrometry (LCMS/MS) and mass spectrometric imaging (MSI), respectively. Healthy female Sprague-Dawley rats received intraperitoneal (i.p.) doses of TBA-354 (20 mg/kg bw). 3. The concentrationtime profiles showed a gradual absorption and tissue penetration of TBA-354 reaching the C max at 6 h post dose, followed by a rapid elimination. MSI analysis showed a time-dependent drug distribution, with highest drug concentration mainly in the neocortical regions of the brain. 4. The distribution of TBA-354 provides a possible explanation for the motor dysfunction observed in clinical trials. These results prove the importance of MSI as a potential tool in preclinical evaluations of suspected neurotoxic compounds.

  4. Occupational Prestige and Its Relationship to Traditional and Non-Traditional Views of Women's Roles.

    ERIC Educational Resources Information Center

    Medvene, Arnold; Collins, Anne

    The social status of occupations has remained stable over the past four decades. However, much about the concept of occupational prestige has been learned by studies that implicitly assume a masculine context. Because of the extensive social and cultural changes associated with the women's equal rights movement, this study asked questions about…

  5. Plain packaging implementation: perceptions of risk and prestige of cigarette brands among Aboriginal and Torres Strait Islander people.

    PubMed

    Maddox, Raglan; Durkin, Sarah; Lovett, Ray

    2016-06-01

    To assess the impact of plain packaging with larger graphic health warnings on perceptions of risk and prestige related to different cigarette brands among Aboriginal and Torres Strait Islander people in the Australian Capital Territory. We hypothesised that the changes would decrease perceptions that 'some cigarette brands are more harmful than others', and that 'some brands are more prestigious than others', and this would be stronger among participants aged ≤35 years, and among smokers compared with non-smokers. Participants completed the survey prior to packaging changes, and were followed up 12 months later (n=98). Repeated measures ANCOVAs assessed perception changes. Following plain packaging implementation, there was a significant reduction in perceptions that 'some cigarette brands are more harmful than others'. There was no overall change in perceptions of prestige. However, there was a significant interaction for age. Analyses indicated a reduction in perceptions that 'some cigarette brands are more prestigious than others' among younger participants (p=0.05), but no change among older participants (p>0.20). There was no interaction for smoking status for perceptions of prestige, indicating smokers' and non-smokers' perceptions did not differ on this measure. These findings provide support for the packaging changes. © 2015 Public Health Association of Australia.

  6. Athletics, Clubs, or Music? The Influence of College Extracurricular Activities on Job Prestige and Satisfaction

    ERIC Educational Resources Information Center

    Kim, Jeongeun; Bastedo, Michael N.

    2017-01-01

    In this study, we investigate how college extracurricular activities influence students' early occupational outcomes. In particular, we examine how the type and number of extracurricular activities, as well as level of participation, influence occupational prestige and job satisfaction. Employing the three national databases, we compare the…

  7. Influence of University Prestige on Graduate Wage and Job Satisfaction: The Case of South Korea

    ERIC Educational Resources Information Center

    Jung, Jisun; Lee, Soo Jeung

    2016-01-01

    Obtaining a tertiary degree no longer guarantees entry to the best occupational positions in today's labour market. Success is no longer about "more" education, but about "better" education for university graduates. This study aims to understand whether university prestige in Korea accounts for occupational outcomes in both…

  8. What Motivates Us for Work? Intricate Web of Factors beyond Money and Prestige

    PubMed Central

    Damij, Nadja; Levnajić, Zoran; Rejec Skrt, Vesna; Suklan, Jana

    2015-01-01

    Efficiency at doing a certain task, at the workplace or otherwise, is strongly influenced by how motivated individuals are. Exploring new ways to motivate employees is often at the top of a company’s agenda. Traditionally identified motivators in Western economies primarily include salary and prestige, often complemented by meaning, creation, challenge, ownership, identity, etc. We report the results of a survey conducted in Slovenia, involving an ensemble of highly educated employees from various public and private organizations. Employing new methodologies such as network analysis, we find that Slovenians are stimulated by an intricate web of interdependent factors, largely in contrast to the traditional understanding that mainly emphasizes money and prestige. In fact, these key motivators only weakly correlate with the demographic parameters. Unexpectedly, we found the evidence of a general optimism in Slovenian professional life - a tendency of the employees to look at the “bright side of things”, thus seeing more clearly the benefits of having something than the drawbacks of not having it. We attribute these particularities to Slovenian recent history, which revolves around gradually embracing the Western (economic) values. PMID:26177271

  9. 44 CFR 354.2 - Scope of this regulation.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... OF HOMELAND SECURITY PREPAREDNESS FEE FOR SERVICES TO SUPPORT FEMA'S OFFSITE RADIOLOGICAL EMERGENCY... subject to requirements for offsite radiological emergency planning and preparedness. ... 44 Emergency Management and Assistance 1 2010-10-01 2010-10-01 false Scope of this regulation. 354...

  10. 29 CFR 1952.354 - Final approval determination.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... effective as operations under the Federal program; to submit plan supplements in accordance with 29 CFR part..., DEPARTMENT OF LABOR (CONTINUED) APPROVED STATE PLANS FOR ENFORCEMENT OF STATE STANDARDS Arizona § 1952.354... benchmarks as revised in 1984 in response to a Court Order in AFL-CIO v. Marshall, (CA 74-406), and was...

  11. 29 CFR 1952.354 - Final approval determination.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... effective as operations under the Federal program; to submit plan supplements in accordance with 29 CFR part..., DEPARTMENT OF LABOR (CONTINUED) APPROVED STATE PLANS FOR ENFORCEMENT OF STATE STANDARDS Arizona § 1952.354... benchmarks as revised in 1984 in response to a Court Order in AFL-CIO v. Marshall, (CA 74-406), and was...

  12. The Parlous State of Academia: When Politics, Prestige and Proxies Overtake Higher Education's Teaching Mission

    ERIC Educational Resources Information Center

    Callier, Viviane; Singiser, Richard H.; Vanderford, Nathan L.

    2015-01-01

    Original and significant research benefits the careers of those running universities and brings prestige to their institution. World class teaching, by and large, does not, and this has important consequences for higher education's tripartite mission. Most notably, emphasis on the research mission of major higher education institutions dwarfs that…

  13. Library and Information Science Journal Prestige as Assessed by Library and Information Science Faculty

    ERIC Educational Resources Information Center

    Manzari, Laura

    2013-01-01

    This prestige study surveyed full-time faculty of American Library Association (ALA)-accredited programs in library and information studies regarding library and information science (LIS) journals. Faculty were asked to rate a list of eighty-nine LIS journals on a scale from 1 to 5 based on each journal's importance to their research and teaching.…

  14. Demand, Funding, and Prestige: Driving the Use of Undergraduate Tuition Discounting in Research 1 Institutions

    ERIC Educational Resources Information Center

    Gunderson, Greg R.

    2009-01-01

    The purpose of the study was to determine (a) if high school enrollment demand, governmental funding capacity, or institutional prestige were predictors of the use of tuition discounts, (b) if increases in tuition discounts stimulated institutional spending capacity, and (c) if tuition discounts trends were notably different if examined from a…

  15. 9 CFR 354.222 - Floors, walls, ceilings, etc.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... Section 354.222 Animals and Animal Products FOOD SAFETY AND INSPECTION SERVICE, DEPARTMENT OF AGRICULTURE AGENCY ORGANIZATION AND TERMINOLOGY; MANDATORY MEAT AND POULTRY PRODUCTS INSPECTION AND VOLUNTARY... prepared or handled shall be constructed of or finished with materials impervious to moisture, so they can...

  16. 14 CFR 35.4 - Instructions for Continued Airworthiness.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... AIRCRAFT AIRWORTHINESS STANDARDS: PROPELLERS General § 35.4 Instructions for Continued Airworthiness. The... program exists to ensure their completion prior to delivery of the first aircraft with the propeller installed, or upon issuance of a standard certificate of airworthiness for an aircraft with the propeller...

  17. 14 CFR 35.4 - Instructions for Continued Airworthiness.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... AIRCRAFT AIRWORTHINESS STANDARDS: PROPELLERS General § 35.4 Instructions for Continued Airworthiness. The... program exists to ensure their completion prior to delivery of the first aircraft with the propeller installed, or upon issuance of a standard certificate of airworthiness for an aircraft with the propeller...

  18. 14 CFR 35.4 - Instructions for Continued Airworthiness.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... AIRCRAFT AIRWORTHINESS STANDARDS: PROPELLERS General § 35.4 Instructions for Continued Airworthiness. The... program exists to ensure their completion prior to delivery of the first aircraft with the propeller installed, or upon issuance of a standard certificate of airworthiness for an aircraft with the propeller...

  19. 14 CFR 35.4 - Instructions for Continued Airworthiness.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... AIRCRAFT AIRWORTHINESS STANDARDS: PROPELLERS General § 35.4 Instructions for Continued Airworthiness. The... program exists to ensure their completion prior to delivery of the first aircraft with the propeller installed, or upon issuance of a standard certificate of airworthiness for an aircraft with the propeller...

  20. 14 CFR 35.4 - Instructions for Continued Airworthiness.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... AIRCRAFT AIRWORTHINESS STANDARDS: PROPELLERS General § 35.4 Instructions for Continued Airworthiness. The... program exists to ensure their completion prior to delivery of the first aircraft with the propeller installed, or upon issuance of a standard certificate of airworthiness for an aircraft with the propeller...

  1. When status is grabbed and when status is granted: Getting ahead in dominance and prestige hierarchies.

    PubMed

    de Waal-Andrews, Wendy; Gregg, Aiden P; Lammers, Joris

    2015-09-01

    What type of behaviour affords status, agentic, or communal? Research to date has yielded inconsistent answers. In particular, the conflict view holds that agentic behaviour permits the imperious to grab status through overt force, whereas the functional view holds that communal behaviour permits the talented to earn status through popular appeal. Here, we synthesize both views by taking into account the moderating role played by group hierarchy. Group hierarchy can range from being dominance based (where status is grabbed) to prestige based (where status is granted). In a field study (Study 1), and a laboratory experiment (Study 2), we demonstrate that in different groups, status can be achieved in different ways. Specifically, agentic behaviour promotes status regardless of hierarchy type, whereas the effect of communal behaviour on status is moderated by hierarchy type: it augments it in more prestige-based hierarchies but diminishes it in more dominance-based hierarchies. © 2014 The British Psychological Society.

  2. In vitro and in vivo activities of the nitroimidazole TBA-354 against Mycobacterium tuberculosis.

    PubMed

    Upton, A M; Cho, S; Yang, T J; Kim, Y; Wang, Y; Lu, Y; Wang, B; Xu, J; Mdluli, K; Ma, Z; Franzblau, S G

    2015-01-01

    Nitroimidazoles are a promising new class of antitubercular agents. The nitroimidazo-oxazole delamanid (OPC-67683, Deltyba) is in phase III trials for the treatment of multidrug-resistant tuberculosis, while the nitroimidazo-oxazine PA-824 is entering phase III for drug-sensitive and drug-resistant tuberculosis. TBA-354 (SN31354[(S)-2-nitro-6-((6-(4-trifluoromethoxy)phenyl)pyridine-3-yl)methoxy)-6,7-dihydro-5H-imidazo[2,1-b][1,3]oxazine]) is a pyridine-containing biaryl compound with exceptional efficacy against chronic murine tuberculosis and favorable bioavailability in preliminary rodent studies. It was selected as a potential next-generation antituberculosis nitroimidazole following an extensive medicinal chemistry effort. Here, we further evaluate the pharmacokinetic properties and activity of TBA-354 against Mycobacterium tuberculosis. TBA-354 is narrow spectrum and bactericidal in vitro against replicating and nonreplicating Mycobacterium tuberculosis, with potency similar to that of delamanid and greater than that of PA-824. The addition of serum protein or albumin does not significantly alter this activity. TBA-354 maintains activity against Mycobacterium tuberculosis H37Rv isogenic monoresistant strains and clinical drug-sensitive and drug-resistant isolates. Spontaneous resistant mutants appear at a frequency of 3 × 10(-7). In vitro studies and in vivo studies in mice confirm that TBA-354 has high bioavailability and a long elimination half-life. In vitro studies suggest a low risk of drug-drug interactions. Low-dose aerosol infection models of acute and chronic murine tuberculosis reveal time- and dose-dependent in vivo bactericidal activity that is at least as potent as that of delamanid and more potent than that of PA-824. Its superior potency and pharmacokinetic profile that predicts suitability for once-daily oral dosing suggest that TBA-354 be studied further for its potential as a next-generation nitroimidazole. Copyright © 2015, American

  3. In Vitro and In Vivo Activities of the Nitroimidazole TBA-354 against Mycobacterium tuberculosis

    PubMed Central

    Cho, S.; Yang, T. J.; Kim, Y.; Wang, Y.; Lu, Y.; Wang, B.; Xu, J.; Mdluli, K.; Ma, Z.; Franzblau, S. G.

    2014-01-01

    Nitroimidazoles are a promising new class of antitubercular agents. The nitroimidazo-oxazole delamanid (OPC-67683, Deltyba) is in phase III trials for the treatment of multidrug-resistant tuberculosis, while the nitroimidazo-oxazine PA-824 is entering phase III for drug-sensitive and drug-resistant tuberculosis. TBA-354 (SN31354[(S)-2-nitro-6-((6-(4-trifluoromethoxy)phenyl)pyridine-3-yl)methoxy)-6,7-dihydro-5H-imidazo[2,1-b][1,3]oxazine]) is a pyridine-containing biaryl compound with exceptional efficacy against chronic murine tuberculosis and favorable bioavailability in preliminary rodent studies. It was selected as a potential next-generation antituberculosis nitroimidazole following an extensive medicinal chemistry effort. Here, we further evaluate the pharmacokinetic properties and activity of TBA-354 against Mycobacterium tuberculosis. TBA-354 is narrow spectrum and bactericidal in vitro against replicating and nonreplicating Mycobacterium tuberculosis, with potency similar to that of delamanid and greater than that of PA-824. The addition of serum protein or albumin does not significantly alter this activity. TBA-354 maintains activity against Mycobacterium tuberculosis H37Rv isogenic monoresistant strains and clinical drug-sensitive and drug-resistant isolates. Spontaneous resistant mutants appear at a frequency of 3 × 10−7. In vitro studies and in vivo studies in mice confirm that TBA-354 has high bioavailability and a long elimination half-life. In vitro studies suggest a low risk of drug-drug interactions. Low-dose aerosol infection models of acute and chronic murine tuberculosis reveal time- and dose-dependent in vivo bactericidal activity that is at least as potent as that of delamanid and more potent than that of PA-824. Its superior potency and pharmacokinetic profile that predicts suitability for once-daily oral dosing suggest that TBA-354 be studied further for its potential as a next-generation nitroimidazole. PMID:25331696

  4. Operational environmental assessment "Prestige" (a recent application of the MOCASSIM system).

    NASA Astrophysics Data System (ADS)

    Vitorino, J.; Rusu, E.; Almeida, S.; Monteiro, M.; Lermusiaux, P.; Haley, P.; Leslie, W.; Miller, P.; Coelho, E.; Signell, R.

    2003-04-01

    The sinking of tanker "Prestige", on the 19th November 2002, offshore the northwestern coasts of Spain and Portugal, has lead to a major environmental disaster. In this contribution we present several aspects of the operational environmental assessment "Prestige" conducted by Instituto Hidrografico (IH) in close colaboration with Instituto de Meteorologia (IM), the Harvard University, the Plymouth Marine Laboratory (PML) and the Saclancentre. The operational system MOCASSIM, which is presently being developed at IH, was used to provide forecasts of the evolution of oceanographic conditions offshore the NW Iberian coast. The system integrates a primitive equation model with data assimilation (the Harvard Ocean Prediction System - HOPS) and two wave models (the SWAN and WW3 models). The numerical domains used in both HOPS and SWAN models covered the area bewteen 40ºN and 46ºN and from 7ºW to 15ºW, and included the sinking area as well as the coastal regions more directly exposed to the oil spill. The models were run with atmospheric forcing conditions provided by the limited area model ALADIN, run operationally at IM, complemented with NOGAPS wind fields from the NATO METOC site of Rota. The HOPS simulations included assimilation of several data available for region. These data sets included CTD casts from the Northern Spanish shelf and slope (made available by University of Baleares) and SST data processed at the Remote Sensing Group of the PML. Results from both models were used in oil spill models and allowed an estimation of the impacts on the coastal areas.

  5. Childhood Cognitive Ability, Education, and Personality Traits Predict Attainment in Adult Occupational Prestige over 17 Years

    ERIC Educational Resources Information Center

    Cheng, Helen; Furnham, Adrian

    2012-01-01

    This study explored a longitudinal data set of nearly 5000 adults examining the effects of childhood cognitive ability (measured at age 11), parental social class (measured at birth), and personality on current occupational prestige (all measured at age 50), taking account the effects of education and the previous occupational levels (both…

  6. 9 CFR 354.132 - Disposal of condemned carcasses and parts.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... AND VOLUNTARY INSPECTION AND CERTIFICATION VOLUNTARY INSPECTION OF RABBITS AND EDIBLE PRODUCTS THEREOF Disposition of Diseased Rabbit Carcasses and Parts § 354.132 Disposal of condemned carcasses and parts. All...

  7. 31 CFR 354.6 - Authority of Federal Reserve Banks.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... accordance with the Securities Documentation, and Federal Reserve Bank Operating Circulars; to service and..., Security Entitlements, and the operation of the Book-entry System under this part. ... SECURITIES OF THE STUDENT LOAN MARKETING ASSOCIATION (SALLIE MAE) § 354.6 Authority of Federal Reserve Banks...

  8. Smiles as signals of lower status in football players and fashion models: evidence that smiles are associated with lower dominance and lower prestige.

    PubMed

    Ketelaar, Timothy; Koenig, Bryan L; Gambacorta, Daniel; Dolgov, Igor; Hor, Daniel; Zarzosa, Jennifer; Luna-Nevarez, Cuauhtémoc; Klungle, Micki; Wells, Lee

    2012-07-10

    Across four studies, the current paper demonstrates that smiles are associated with lower social status. Moreover, the association between smiles and lower status appears in the psychology of observers and generalizes across two forms of status: prestige and dominance. In the first study, faces of fashion models representing less prestigious apparel brands were found to be more similar to a canonical smile display than the faces of models representing more prestigious apparel brands. In a second study, after being experimentally primed with either high or low prestige fashion narratives, participants in the low prestige condition were more likely to perceive smiles in a series of photographs depicting smiling and non-smiling faces. A third study of football player photographs revealed that the faces of less dominant (smaller) football players were more similar to the canonical smile display than the faces of their physically larger counterparts. Using the same football player photographs, a fourth study found that smiling was a more reliable indicator of perceived status-relevant personality traits than perceptions of the football players' physical sizes inferred from the photographs.

  9. Take me where I want to go: Institutional prestige, advisor sponsorship, and academic career placement preferences.

    PubMed

    Pinheiro, Diogo L; Melkers, Julia; Newton, Sunni

    2017-01-01

    Placement in prestigious research institutions for STEM (science, technology, engineering, and mathematics) PhD recipients is generally considered to be optimal. Yet some doctoral recipients are not interested in intensive research careers and instead seek alternative careers, outside but also within academe (for example teaching positions in Liberal Arts Schools). Recent attention to non-academic pathways has expanded our understanding of alternative PhD careers. However, career preferences and placements are also nuanced along the academic pathway. Existing research on academic careers (mostly research-centric) has found that certain factors have a significant impact on the prestige of both the institutional placement and the salary of PhD recipients. We understand less, however, about the functioning of career preferences and related placements outside of the top academic research institutions. Our work builds on prior studies of academic career placement to explore the impact that prestige of PhD-granting institution, advisor involvement, and cultural capital have on the extent to which STEM PhDs are placed in their preferred academic institution types. What determines whether an individual with a preference for research oriented institutions works at a Research Extensive university? Or whether an individual with a preference for teaching works at a Liberal Arts college? Using survey data from a nationally representative sample of faculty in biology, biochemistry, civil engineering and mathematics at four different Carnegie Classified institution types (Research Extensive, Research Intensive, Master's I & II, and Liberal Arts Colleges), we examine the relative weight of different individual and institutional characteristics on institutional type placement. We find that doctoral institutional prestige plays a significant role in matching individuals with their preferred institutional type, but that advisor involvement only has an impact on those with a

  10. Take me where I want to go: Institutional prestige, advisor sponsorship, and academic career placement preferences

    PubMed Central

    Pinheiro, Diogo L.; Newton, Sunni

    2017-01-01

    Placement in prestigious research institutions for STEM (science, technology, engineering, and mathematics) PhD recipients is generally considered to be optimal. Yet some doctoral recipients are not interested in intensive research careers and instead seek alternative careers, outside but also within academe (for example teaching positions in Liberal Arts Schools). Recent attention to non-academic pathways has expanded our understanding of alternative PhD careers. However, career preferences and placements are also nuanced along the academic pathway. Existing research on academic careers (mostly research-centric) has found that certain factors have a significant impact on the prestige of both the institutional placement and the salary of PhD recipients. We understand less, however, about the functioning of career preferences and related placements outside of the top academic research institutions. Our work builds on prior studies of academic career placement to explore the impact that prestige of PhD-granting institution, advisor involvement, and cultural capital have on the extent to which STEM PhDs are placed in their preferred academic institution types. What determines whether an individual with a preference for research oriented institutions works at a Research Extensive university? Or whether an individual with a preference for teaching works at a Liberal Arts college? Using survey data from a nationally representative sample of faculty in biology, biochemistry, civil engineering and mathematics at four different Carnegie Classified institution types (Research Extensive, Research Intensive, Master’s I & II, and Liberal Arts Colleges), we examine the relative weight of different individual and institutional characteristics on institutional type placement. We find that doctoral institutional prestige plays a significant role in matching individuals with their preferred institutional type, but that advisor involvement only has an impact on those with a

  11. Time-frequency dynamics during sleep spindles on the EEG in rodents with a genetic predisposition to absence epilepsy (WAG/Rij rats)

    NASA Astrophysics Data System (ADS)

    Hramov, Alexander E.; Sitnikova, Evgenija Y.; Pavlov, Alexey N.; Grubov, Vadim V.; Koronovskii, Alexey A.; Khramova, Marina V.

    2015-03-01

    Sleep spindles are known to appear spontaneously in the thalamocortical neuronal network of the brain during slow-wave sleep; pathological processes in the thalamocortical network may be the reason of the absence epilepsy. The aim of the present work is to study developed changes in the time-frequency structure of sleep spindles during the progressive development of the absence epilepsy in WAG/Rij rats. EEG recordings were made at age 7 and 9 months. Automatic recognition and subsequent analysis of sleep spindles on the EEG were performed using the continuous wavelet transform. The duration of epileptic discharges and the total duration of epileptic activity were found to increase with age, while the duration of sleep spindles, conversely, decreased. In terms of the mean frequency, sleep spindles could be divided into three classes: `slow' (mean frequency 9.3Hz), `medium' (11.4Hz), and `fast' (13.5Hz). Slow and medium (transitional) spindles in five-month-old animals showed increased frequency from the beginning to the end of the spindle. The more intense the epilepsy is, the shorter are the durations of spindles of all types. The mean frequencies of `medium' and `fast' spindles were higher in rats with more intense signs of epilepsy. Overall, high epileptic activity in WAG/Rij rats was linked with significant changes in spindles of the transitional type, with less marked changes in the two traditionally identified types of spindle, slow and fast.

  12. 7 CFR 1940.325 - FmHA or its successor agency under Public Law 103-354 as a cooperating Agency.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... Environmental Program § 1940.325 FmHA or its successor agency under Public Law 103-354 as a cooperating Agency. (a) FmHA or its successor agency under Public Law 103-354 will serve as a cooperating Agency when... successor agency under Public Law 103-354 action. An example of the latter would be a request from EPA to...

  13. Theoretical Study on Sers of Wagging Vibrations of Benzyl Radical Adsorbed on Silver Electrodes

    NASA Astrophysics Data System (ADS)

    Wu, De-Yin; Chen, Yan-Li; Tian, Zhong-Qun

    2016-06-01

    Electrochemical surface-enhanced Raman spectroscopy (EC-SERS) has been used to characterize adsorbed species widely but reaction intermediates rarely on electrodes. In previous studies, the observed SERS signals were proposed from surface benzyl species due to the electrochemical reduction of benzyl chloride on silver electrode surfaces. In this work, we reinvestigated the vibrational assignments of benzyl chloride and benzyl radical as the reaction intermediate. On the basis of density functional theoretical (DFT) calculations and normal mode analysis, our systematical results provide more reasonable new assignments for both surface species. Further, we investigated adsorption configurations, binding energies, and vibrational frequency shifts of benzyl radical interacting with silver. Our calculated results show that the wagging vibration displays significant vibrational frequency shift, strong coupling with some intramolecular modes in the phenyl ring, and significant changes in intensity of Raman signals. The study also provides absolute Raman intensity in benzyl halides and discuss the enhancement effect mainly due to the binding interaction with respect to free benzyl radical.

  14. Brief alcohol intervention trials conducted by higher prestige authors and published in higher impact factor journals are cited more frequently.

    PubMed

    Tanner-Smith, Emily E; Polanin, Joshua R

    2016-07-01

    To examine the relationships between study quality, author prestige, journal impact factors, and citation rates of trials and to examine whether journal impact factors mediated the relationships between study quality and author prestige on citation rates. We used bibliometric data from 128 controlled trials included in a recent meta-analysis on brief alcohol interventions for adolescents and young adults. We obtained the number of citations from ISI Web of Knowledge and Google Scholar; journal impact factors were obtained from ISI Web of Knowledge. Linear regression models were used to examine the direct and indirect effects of interest. The results indicated that studies were published in journals with higher impact factors when first authors had higher h-indices and studies were funded, but this was largely because those studies were of higher quality. Studies were cited more frequently when first authors had higher h-indices and studies were funded, even after adjusting for study quality proxies. The observed associations between study quality and author prestige on citation rates were also partly mediated through journal impact factors. We conclude that studies conducted by more established authors and reported in more prestigious journal outlets are more likely to be cited by other scholars, even after controlling for various proxies of study quality. Copyright © 2016 Elsevier Inc. All rights reserved.

  15. Brief Alcohol Intervention Trials Conducted by Higher Prestige Authors and Published in Higher Impact Factor Journals are Cited More Frequently

    PubMed Central

    Tanner-Smith, Emily E.; Polanin, Joshua R.

    2016-01-01

    Objective To examine the relationships between study quality, author prestige, journal impact factors, and citation rates of trials; and to examine whether journal impact factors mediated the relationships between study quality and author prestige on citation rates. Study Design and Setting We used bibliometric data from 128 controlled trials included in a recent meta-analysis on brief alcohol interventions (BAIs) for adolescents and young adults. We obtained the number of citations from ISI Web of Knowledge and Google Scholar; journal impact factors were obtained from ISI Web of Knowledge. Linear regression models were used to examine the direct and indirect effects of interest. Results The results indicated that studies were published in journals with higher impact factors when first authors had higher h-indices and studies were funded, but this was largely because those studies were of higher quality. Studies were cited more frequently when first authors had higher h-indices and studies were funded, even after adjusting for study quality proxies. The observed associations between study quality and author prestige on citation rates were also partly mediated through journal impact factors. Conclusion We conclude that studies conducted by more established authors and reported in more prestigious journal outlets are more likely to be cited by other scholars, even after controlling for various proxies of study quality. PMID:26854420

  16. Prestige among Graduate and Professional Schools: Comparing the "U.S. News'" Graduate School Reputation Ratings between Disciplines

    ERIC Educational Resources Information Center

    Sweitzer, Kyle; Volkwein, J. Fredericks

    2009-01-01

    Using a conceptual model, this study examines the variables associated with the "U.S. News and World Report" peer assessment ratings of graduate and professional schools in business, education, engineering, law, and medicine. What are the correlates of prestige among the nation's leading graduate and professional schools, and are they consistent…

  17. 7 CFR 1940.325 - FmHA or its successor agency under Public Law 103-354 as a cooperating Agency.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 7 Agriculture 13 2011-01-01 2009-01-01 true FmHA or its successor agency under Public Law 103-354... Environmental Program § 1940.325 FmHA or its successor agency under Public Law 103-354 as a cooperating Agency. (a) FmHA or its successor agency under Public Law 103-354 will serve as a cooperating Agency when...

  18. 7 CFR 1940.326 - FmHA or its successor agency under Public Law 103-354 as a lead Agency.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 7 Agriculture 13 2010-01-01 2009-01-01 true FmHA or its successor agency under Public Law 103-354... Environmental Program § 1940.326 FmHA or its successor agency under Public Law 103-354 as a lead Agency. (a) When other Federal agencies are involved in an FmHA or its successor agency under Public Law 103-354...

  19. 7 CFR 1940.326 - FmHA or its successor agency under Public Law 103-354 as a lead Agency.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 7 Agriculture 13 2011-01-01 2009-01-01 true FmHA or its successor agency under Public Law 103-354... Environmental Program § 1940.326 FmHA or its successor agency under Public Law 103-354 as a lead Agency. (a) When other Federal agencies are involved in an FmHA or its successor agency under Public Law 103-354...

  20. 44 CFR 354.6 - Billing and payment of fees.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... EMERGENCY PREPAREDNESS PROGRAM § 354.6 Billing and payment of fees. (a) Electronic billing and payment. We will deposit all funds collected under this part to the Radiological Emergency Preparedness Fund as... 44 Emergency Management and Assistance 1 2010-10-01 2010-10-01 false Billing and payment of fees...

  1. 14 CFR 121.354 - Terrain awareness and warning system.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 14 Aeronautics and Space 3 2011-01-01 2011-01-01 false Terrain awareness and warning system. 121... § 121.354 Terrain awareness and warning system. (a) Airplanes manufactured after March 29, 2002. No... awareness and warning system that meets the requirements for Class A equipment in Technical Standard Order...

  2. 14 CFR 121.354 - Terrain awareness and warning system.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 14 Aeronautics and Space 3 2010-01-01 2010-01-01 false Terrain awareness and warning system. 121... § 121.354 Terrain awareness and warning system. (a) Airplanes manufactured after March 29, 2002. No... awareness and warning system that meets the requirements for Class A equipment in Technical Standard Order...

  3. 14 CFR 121.354 - Terrain awareness and warning system.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 14 Aeronautics and Space 3 2014-01-01 2014-01-01 false Terrain awareness and warning system. 121... § 121.354 Terrain awareness and warning system. (a) Airplanes manufactured after March 29, 2002. No... awareness and warning system that meets the requirements for Class A equipment in Technical Standard Order...

  4. 14 CFR 121.354 - Terrain awareness and warning system.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 14 Aeronautics and Space 3 2012-01-01 2012-01-01 false Terrain awareness and warning system. 121... § 121.354 Terrain awareness and warning system. (a) Airplanes manufactured after March 29, 2002. No... awareness and warning system that meets the requirements for Class A equipment in Technical Standard Order...

  5. 14 CFR 121.354 - Terrain awareness and warning system.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 14 Aeronautics and Space 3 2013-01-01 2013-01-01 false Terrain awareness and warning system. 121... § 121.354 Terrain awareness and warning system. (a) Airplanes manufactured after March 29, 2002. No... awareness and warning system that meets the requirements for Class A equipment in Technical Standard Order...

  6. 7 CFR 1901.506 - Book-entry procedure for FmHA or its successor agency under Public Law 103-354 securities...

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... under Public Law 103-354 securities-issuance and redemption of certificate by Reserve bank. 1901.506... applied to such FmHA or its successor agency under Public Law 103-354 securities, the Reserve bank is... successor agency under Public Law 103-354 securities. (3) A Reserve bank as fiscal agent of the United...

  7. 31 CFR 354.6 - Authority of Federal Reserve Banks.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 31 Money and Finance:Treasury 2 2011-07-01 2011-07-01 false Authority of Federal Reserve Banks... SECURITIES OF THE STUDENT LOAN MARKETING ASSOCIATION (SALLIE MAE) § 354.6 Authority of Federal Reserve Banks. (a) Each Federal Reserve Bank is hereby authorized as fiscal agent of Sallie Mae to perform functions...

  8. 44 CFR 354.5 - Description of site-specific, plume pathway EPZ biennial exercise-related component services and...

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ..., plume pathway EPZ biennial exercise-related component services and other services. 354.5 Section 354.5... Description of site-specific, plume pathway EPZ biennial exercise-related component services and other... will assess fees on licensees include the following: (a) Site-specific, plume pathway EPZ biennial...

  9. 42 CFR 438.354 - Qualifications of external quality review organizations.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 42 Public Health 4 2010-10-01 2010-10-01 false Qualifications of external quality review... HEALTH AND HUMAN SERVICES (CONTINUED) MEDICAL ASSISTANCE PROGRAMS MANAGED CARE External Quality Review § 438.354 Qualifications of external quality review organizations. (a) General rule. The State must...

  10. The tail wags the dog: managing large telescope construction projects with lagging requirements and creeping scope

    NASA Astrophysics Data System (ADS)

    Warner, Mark

    2014-08-01

    -picture decisions early, and designing flexibility and adaptability into subsystems. In a perfect world, science would be the big dog in the room, wagging the engineering tail. In our non-perfect world, however, it's often the tail that ends up wagging the dog instead.

  11. A Different Type of Charter School: In Prestige Charters, a Rise in Cachet Equals a Decline in Access

    ERIC Educational Resources Information Center

    Brown, Elizabeth; Makris, Molly Vollman

    2018-01-01

    This paper seeks to elucidate a specific type of charter school. While much has been written about school choice and the expanding charter school segment, a growing and important number of charter schools do not fit in to the common understanding of these schools. Distinct from many of their counterparts, "prestige charter schools" have…

  12. 9 CFR 354.26 - Schedule of operation of official plants.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... Performance of Services § 354.26 Schedule of operation of official plants. Inspection operating schedules for... operation shall be reasonably uniform from day to day. Inspectors are to be notified by management 1 day in advance of any change in the hours inspection service is requested. Application for Inspection Service ...

  13. Temporal estimates of genetic diversity in some Mytilus galloprovincialis populations impacted by the Prestige oil-spill

    NASA Astrophysics Data System (ADS)

    Lado-Insua, Tanya; Pérez, Montse; Diz, Angel P.; Presa, Pablo

    2011-04-01

    The sinking of the tanker Prestige in November 2002 off the coast of Galicia resulted in the release of about 60,000 tons of heavy oil. The oil-spill provoked a serious environmental impact in Spanish and French coasts, which biological consequences are still being assessed. In this study we address the temporal dynamics of genetic diversity in some mussel populations impacted by the oil-spill. Changes in genetic diversity can be measured in natural populations provided that serial samples are available from before (year 2000) and after (years 2003, 2005) the oil-spill. Analyses of seven microsatellites indicate a weak but significant increase of genetic variation after the spill. This phenomenon is interpreted herein in terms of a balance between a enhanced genome mutability on microsatellite variation and a low genetic drift due to toxicants and asphyxia although other stochastic phenomena cannot be ruled out. Per locus annotation showed that in spite of the allelic changes observed in the period 2000-2005, the final size of most allelic series remained quite alike to those of year 2000. Present genetic data suggest that the genotoxic impact of the Prestige spill did not compromise the genetic diversity of studied mussel populations, at least regarding the genetic markers analysed.

  14. A randomized, controlled phase I/II study to evaluate the safety and efficacy of MGV354 for ocular hypertension or glaucoma.

    PubMed

    Stacy, Rebecca; Huttner, Kenneth; Watts, Jen; Peace, James; Wirta, David; Walters, Tom; Sall, Kenneth; Seaman, John; Ni, Xiao; Prasanna, Ganesh; Mogi, Muneto; Adams, Christopher; Yan, Jing-He; Wald, Michael; He, Yunsheng; Newton, Ronald; Kolega, Randall; Grosskreutz, Cynthia

    2018-05-23

    To assess the clinical safety, tolerability, and efficacy of topically administered MGV354, a soluble guanylate cyclase (sGC) activator, in patients with ocular hypertension (OH) or glaucoma DESIGN: Double-masked, randomized, and vehicle-controlled study METHODS: Parts 1 and 2 evaluated safety and tolerability to identify the maximum tolerated dose (MTD) of once daily MGV354 in 32 healthy volunteers (Part 1) and 16 patients with OH or glaucoma (Part 2) at a single clinical site. Part 3 was a multi-site trial that evaluated IOP-lowering efficacy of the MTD administered nightly for one week in 50 patients with minimum IOP of 24mm Hg at 8 AM, with a main outcome measure of mean diurnal IOP at Day 8 compared to baseline (ClinicalTrials.gov NCT02743780). There was no difference in favor of MGV354 for IOP lowering; change from Baseline to Day 8 in mean diurnal IOP was -0.6 mmHg for MGV354-treated patients and -1.1 mmHg for Vehicle-treated patients in Part 3, with a confidence interval of -0.7 to 1.7. The most common adverse events reported after MGV354 administration were conjunctival and ocular hyperemia. Overall, MGV354 0.1% demonstrated no statistically significant effect compared to Vehicle in lowering IOP based upon the study's main outcome measure. MGV354 produced ocular hyperemia consistent with its pharmacology. Copyright © 2018 Elsevier Inc. All rights reserved.

  15. 7 CFR 1950.104 - Borrower owing FmHA or its successor agency under Public Law 103-354 loans which are secured by...

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... Public Law 103-354 loans which are secured by real estate. 1950.104 Section 1950.104 Agriculture... owing FmHA or its successor agency under Public Law 103-354 loans which are secured by real estate... borrowers with FmHA or its successor agency under Public Law 103-354 loans secured by real estate who may...

  16. 9 CFR 354.130 - Diseases or conditions evident which require condemnation.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 9 Animals and Animal Products 2 2011-01-01 2011-01-01 false Diseases or conditions evident which... PRODUCTS THEREOF Disposition of Diseased Rabbit Carcasses and Parts § 354.130 Diseases or conditions... the following named diseases or conditions shall be condemned: Tularemia, anthrax, hemorrhagic...

  17. 9 CFR 354.130 - Diseases or conditions evident which require condemnation.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 9 Animals and Animal Products 2 2010-01-01 2010-01-01 false Diseases or conditions evident which... PRODUCTS THEREOF Disposition of Diseased Rabbit Carcasses and Parts § 354.130 Diseases or conditions... the following named diseases or conditions shall be condemned: Tularemia, anthrax, hemorrhagic...

  18. 9 CFR 354.130 - Diseases or conditions evident which require condemnation.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 9 Animals and Animal Products 2 2012-01-01 2012-01-01 false Diseases or conditions evident which... PRODUCTS THEREOF Disposition of Diseased Rabbit Carcasses and Parts § 354.130 Diseases or conditions... the following named diseases or conditions shall be condemned: Tularemia, anthrax, hemorrhagic...

  19. 9 CFR 354.130 - Diseases or conditions evident which require condemnation.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 9 Animals and Animal Products 2 2013-01-01 2013-01-01 false Diseases or conditions evident which... PRODUCTS THEREOF Disposition of Diseased Rabbit Carcasses and Parts § 354.130 Diseases or conditions... the following named diseases or conditions shall be condemned: Tularemia, anthrax, hemorrhagic...

  20. 9 CFR 354.130 - Diseases or conditions evident which require condemnation.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 9 Animals and Animal Products 2 2014-01-01 2014-01-01 false Diseases or conditions evident which... PRODUCTS THEREOF Disposition of Diseased Rabbit Carcasses and Parts § 354.130 Diseases or conditions... the following named diseases or conditions shall be condemned: Tularemia, anthrax, hemorrhagic...

  1. 9 CFR 354.141 - Issuance and disposition of rabbits inspection certificates.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 9 Animals and Animal Products 2 2011-01-01 2011-01-01 false Issuance and disposition of rabbits... PRODUCTS INSPECTION AND VOLUNTARY INSPECTION AND CERTIFICATION VOLUNTARY INSPECTION OF RABBITS AND EDIBLE PRODUCTS THEREOF Inspection Certificates § 354.141 Issuance and disposition of rabbits inspection...

  2. 9 CFR 354.141 - Issuance and disposition of rabbits inspection certificates.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 9 Animals and Animal Products 2 2010-01-01 2010-01-01 false Issuance and disposition of rabbits... PRODUCTS INSPECTION AND VOLUNTARY INSPECTION AND CERTIFICATION VOLUNTARY INSPECTION OF RABBITS AND EDIBLE PRODUCTS THEREOF Inspection Certificates § 354.141 Issuance and disposition of rabbits inspection...

  3. Engineering and blue-collar occupations prestige in the minds of industrial city students (Naberezhniye Chelny city experience)

    NASA Astrophysics Data System (ADS)

    Kayumov, A. T.; Mustafina, D. N.

    2014-12-01

    In this research work an attempt is made to reveal the factors and level of engineering and working professions prestige in the minds of studying youth on the basis of empiric data. The results of research allow revealing the mechanism of social-professional selfidentification of school-aged youth, on the basis of which an opportunity to study in a new way traditional system of profession-oriented work appears.

  4. Blockade of CD354 (TREM-1) Ameliorates Anti-GBM-Induced Nephritis.

    PubMed

    Du, Yong; Wu, Tianfu; Zhou, Xin J; Davis, Laurie S; Mohan, Chandra

    2016-06-01

    CD354, Triggering Receptor of Myeloid Cells-1 (TREM-1), is a potent amplifier of myeloid immune responses. Our goal was to determine the expression and function of TREM-1 in immune-mediated nephritis. An anti-glomerular basement membrane antibody (anti-GBM)-induced nephritis model was employed, where mice were sensitized with rabbit IgG followed by anti-GBM serum to induce disease. Anti-GBM-treated 129x1/svJ mice developed severe nephritis whereas C57BL/6 (B6) mice were resistant to disease. Anti-GBM disease resulted in elevated renal TREM-1 messenger RNA (mRNA) and protein levels and increased urine TREM-1 levels in 129x1/svJ. TREM-1 blockade with an inhibitory peptide, LP17, inhibited proteinuria and renal disease as measured by glomerulonephritis class, severity of tubulointerstitial disease, crescent formation, and inflammatory cell infiltrates. In sum, TREM-1 is upregulated in renal inflammation and plays a vital role in driving disease. Thus, TREM-1 blockade emerges as a potential therapeutic avenue for immune-mediated renal diseases such as lupus nephritis.

  5. 42 CFR 411.354 - Financial relationship, compensation, and ownership or investment interest.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... Health Services § 411.354 Financial relationship, compensation, and ownership or investment interest. (a) Financial relationships. (1) Financial relationship means— (i) A direct or indirect ownership or investment... financial relationship. (3) Ownership and investment interests do not include, among other things— (i) An...

  6. 7 CFR 1956.145 - Disposition of essential FmHA or its successor agency under Public Law 103-354 records.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 7 Agriculture 14 2010-01-01 2009-01-01 true Disposition of essential FmHA or its successor agency... SETTLEMENT Debt Settlement-Community and Business Programs § 1956.145 Disposition of essential FmHA or its successor agency under Public Law 103-354 records. FmHA or its successor agency under Public Law 103-354...

  7. 7 CFR 1956.145 - Disposition of essential FmHA or its successor agency under Public Law 103-354 records.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 7 Agriculture 14 2011-01-01 2011-01-01 false Disposition of essential FmHA or its successor agency... SETTLEMENT Debt Settlement-Community and Business Programs § 1956.145 Disposition of essential FmHA or its successor agency under Public Law 103-354 records. FmHA or its successor agency under Public Law 103-354...

  8. The Effects of Prestige and Identification Factors on Attitude Restructuring and Learning from Sound Films. Rapid Mass Learning. Technical Report.

    ERIC Educational Resources Information Center

    Kishler, John P.

    An experiment was conducted to study the effect that audience attitude toward, and identification with the main character of a film has on learning from the film. Two hypotheses were formulated. 1) People for whom the occupational role of the main character has a high prestige value will learn more factual information from the film and also change…

  9. 31 CFR 354.2 - Law governing rights and obligations of Federal Reserve Banks, and Sallie Mae; rights of any...

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... on the books of a Federal Reserve Bank pursuant to § 354.4(c)(1), is governed by the law (not... recorded on the books of a Federal Reserve Bank pursuant to § 354.14(c)(1), is governed by the law... 31 Money and Finance: Treasury 2 2010-07-01 2010-07-01 false Law governing rights and obligations...

  10. Ten years after the prestige oil spill: seabird trophic ecology as indicator of long-term effects on the coastal marine ecosystem.

    PubMed

    Moreno, Rocío; Jover, Lluís; Diez, Carmen; Sardà-Palomera, Francesc; Sardà, Francesc; Sanpera, Carola

    2013-01-01

    Major oil spills can have long-term impacts since oil pollution does not only result in acute mortality of marine organisms, but also affects productivity levels, predator-prey dynamics, and damages habitats that support marine communities. However, despite the conservation implications of oil accidents, the monitoring and assessment of its lasting impacts still remains a difficult and daunting task. Here, we used European shags to evaluate the overall, lasting effects of the Prestige oil spill (2002) on the affected marine ecosystem. Using δ ¹⁵N and Hg analysis, we trace temporal changes in feeding ecology potentially related to alterations of the food web due to the spill. Using climatic and oceanic data, we also investigate the influence of North Atlantic Oscillation (NAO) index, the sea surface temperature (SST) and the chlorophyll a (Chl a) on the observed changes. Analysis of δ ¹⁵N and Hg concentrations revealed that after the Prestige oil spill, shag chicks abruptly switched their trophic level from a diet based on a high percentage of demersal-benthic fish to a higher proportion of pelagic/semi-pelagic species. There was no evidence that Chl a, SST and NAO reflected any particular changes or severity in environmental conditions for any year or season that may explain the sudden change observed in trophic level. Thus, this study highlighted an impact on the marine food web for at least three years. Our results provide the best evidence to date of the long-term consequences of the Prestige oil spill. They also show how, regardless of wider oceanographic variability, lasting impacts on predator-prey dynamics can be assessed using biochemical markers. This is particularly useful if larger scale and longer term monitoring of all trophic levels is unfeasible due to limited funding or high ecosystem complexity.

  11. Monitoring of the impact of Prestige oil spill on Mytilus galloprovincialis from Galician coast.

    PubMed

    Laffon, Blanca; Rábade, Tamara; Pásaro, Eduardo; Méndez, Josefina

    2006-04-01

    In November 2002, the Prestige oil tanker was wrecked in front of Galician coast (NW of Spain), spilling near 63,000 tons of heavy oil until February 2003. Contamination produced was very extensive (70% of Galician beaches were reached by the oil) but heterogeneous, alternating intensely affected zones with neighbour locations where the repercussion was minimal. The objective of this study was to monitor sea environment contamination caused by Prestige oil spill during an 11-month period (August 2003-June 2004, nine samplings) in two locations of Galician coast with different geographical properties (Lira and Ancoradoiro beaches), by means of chemical determination of total polycyclic aromatic hydrocarbons (TPAH) in seawater, and using as exposure biomarker TPAH content in mussel (Mytilus galloprovincialis) tissues, and as effect biomarker DNA damage in mussel gills, evaluated by the comet assay. In addition, recovery ability of the mussels was determined after a 7-day stay in the laboratory. TPAH contents in seawater were very high in the earliest samplings, but then they maintained below 200 ng L(-)(1), similar to reference seawater. However, TPAH levels in mussel tissues were more variable: they increased again from January 2004, probably due to the adverse meteorological conditions that turned over the sea bottom and dispersed the oil accumulated in sediments. In most samplings, these levels decreased during the recovery stage. DNA damage in oil-exposed mussels was significantly higher than in reference mussels, both before and after the recovery phase, but they did not differ to one another. Comet tail length was slightly reduced during the recovery stage, indicative of a certain DNA repair in exposed mussels. This study showed up the importance of monitoring sea contamination events during an extended time, not only in evaluating the presence of the contaminants in the environment but also in determining their bioaccumulation and their effect on the exposed

  12. Outlet Glacier-Ice Shelf-Ocean Interactions: Is the Tail Wagging the Dog?

    NASA Astrophysics Data System (ADS)

    Parizek, B. R.; Walker, R. T.; Rinehart, S. K.

    2009-12-01

    While the massive interior regions of the Antarctic and Greenland Ice Sheets are presently ``resting quietly", the lower elevations of many outlet glaciers are experiencing dramatic adjustments due to changes in ice dynamics and/or surface mass balance. Oceanic and/or atmospheric forcing in these marginal regions often leads to mass deficits for entire outlet basins. Therefore, coupling the wagging tail of ice-ocean interactions with the vast ice-sheet reservoirs is imperative for accurate assessments of future sea-level rise. To study ice-ocean dynamic processes, we couple an ocean-plume model that simulates ice-shelf basal melting rates based on temperature and salinity profiles combined with plume dynamics associated with the geometry of the ice-shelf cavity (following Jenkins, 1991 and Holland and Jenkins, 1999) with a two-dimensional, isothermal model of outlet glacier-ice shelf flow (as used in Alley et al., 2007; Walker et al., 2008; Parizek et al., in review). Depending on the assigned temperature and salinity profiles, the ocean model can simulate both water-mass end-members: either cold High Salinity Shelf Water (HSSW) or relatively warm Circumpolar Deep Water (CDW), as well as between-member conditions. Notably, the coupled system exhibits sensitivity to the initial conditions. In particular, melting concentrated near the grounding line has the greatest effect in forcing grounding-line retreat. Retreat is further enhanced by a positive feedback between the ocean and ice, as the focused melt near the grounding line leads to an increase in the local slope of the basal ice, thereby enhancing buoyancy-driven plume flow and subsequent melt rates.

  13. Cannabis agonist injection effect on the coupling architecture in cortex of WAG/Rij rats during absence seizures

    NASA Astrophysics Data System (ADS)

    Sysoeva, Marina V.; Kuznetsova, Galina D.; van Rijn, Clementina M.; Sysoev, Ilya V.

    2016-04-01

    WAG/Rij rats are well known genetic model of absence epilepsy, which is traditionally considered as a nonconvulsive generalised epilepsy of unknown aetiology. In current study the effect of (R)-(+)-WIN 55,212-2 (cannabis agonist) injection on the coupling between different parts of cortex was studied on 27 male 8 month old rats using local field potentials. Recently developed non-linear adapted Granger causality approach was used as a primary method. It was shown that first 2 hours after the injection the coupling between most channel pairs rises in comparison with the spontaneous activity, whilst long after the injection (2-6 hours) it drops down. The coupling increase corresponds to the mentioned before treatment effect, when the number and the longitude of seizures significantly decreases. However the subsequent decrease of the coupling in the cortex is accompanied by the dramatic increase of the longitude and the number of seizures. This assumes the hypothesis that a relatively higher coupling in the cortical network can prevent the seizure propagation and generalisation.

  14. 24 CFR 3282.354 - Submittal of false information or refusal to submit information.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 24 Housing and Urban Development 5 2010-04-01 2010-04-01 false Submittal of false information or... ENFORCEMENT REGULATIONS Primary Inspection Agencies § 3282.354 Submittal of false information or refusal to submit information. The submittal of false information or the refusal to submit information required...

  15. Prestige Asymmetry in American Physics: Aspirations, Applications, and the Purloined Letter Effect.

    PubMed

    Martin, Joseph D

    2017-12-01

    Argument Why do similar scientific enterprises garner unequal public approbation? High energy physics attracted considerable attention in the late-twentieth-century United States, whereas condensed matter physics - which occupied the greater proportion of US physicists - remained little known to the public, despite its relevance to ubiquitous consumer technologies. This paper supplements existing accounts of this much remarked-upon prestige asymmetry by showing that popular emphasis on the mundane technological offshoots of condensed matter physics and its focus on human-scale phenomena have rendered it more recondite than its better-known sibling field. News reports about high energy physics emphasize intellectual achievement; reporting on condensed matter physics focuses on technology. And whereas frontier-oriented rhetoric of high energy physics communicates ideals of human potential, discoveries that smack of the mundane highlight human limitations and fail to resonate with the widespread aspirational vision of science - a consequence I call "the purloined letter effect."

  16. Contribution of the Nitroimidazoles PA-824 and TBA-354 to the Activity of Novel Regimens in Murine Models of Tuberculosis

    PubMed Central

    Tasneen, Rokeya; Williams, Kathy; Amoabeng, Opokua; Minkowski, Austin; Mdluli, Khisimuzi E.; Upton, Anna M.

    2014-01-01

    New regimens based on two or more novel agents are sought in order to shorten or simplify the treatment of both drug-susceptible and drug-resistant forms of tuberculosis. PA-824 is a nitroimidazo-oxazine now in phase II trials and has shown significant early bactericidal activity alone and in combination with the newly approved agent bedaquiline or with pyrazinamide with or without moxifloxacin. While the development of PA-824 continues, a potential next-generation derivative, TBA-354, has been discovered to have in vitro potency superior to that of PA-824 and greater metabolic stability than that of the other nitroimidazole derivative in clinical development, delamanid. In the present study, we compared the activities of PA-824 and TBA-354 as monotherapies in murine models of the initial intensive and continuation phases of treatment, as well as in combination with bedaquiline plus pyrazinamide, sutezolid, and/or clofazimine. The monotherapy studies demonstrated that TBA-354 is 5 to 10 times more potent than PA-824, but selected mutants are cross-resistant to PA-824 and delamanid. The combination studies revealed that TBA-354 is 2 to 4 times more potent than PA-824 when combined with bedaquiline, and when administered at a dose equivalent to that of PA-824, TBA-354 demonstrated superior sterilizing efficacy. Perhaps most importantly, the addition of either nitroimidazole significantly improved the sterilizing activities of bedaquiline and sutezolid, with or without pyrazinamide, confirming the value of each agent in this potentially universally active short-course regimen. PMID:25331697

  17. Contribution of the nitroimidazoles PA-824 and TBA-354 to the activity of novel regimens in murine models of tuberculosis.

    PubMed

    Tasneen, Rokeya; Williams, Kathy; Amoabeng, Opokua; Minkowski, Austin; Mdluli, Khisimuzi E; Upton, Anna M; Nuermberger, Eric L

    2015-01-01

    New regimens based on two or more novel agents are sought in order to shorten or simplify the treatment of both drug-susceptible and drug-resistant forms of tuberculosis. PA-824 is a nitroimidazo-oxazine now in phase II trials and has shown significant early bactericidal activity alone and in combination with the newly approved agent bedaquiline or with pyrazinamide with or without moxifloxacin. While the development of PA-824 continues, a potential next-generation derivative, TBA-354, has been discovered to have in vitro potency superior to that of PA-824 and greater metabolic stability than that of the other nitroimidazole derivative in clinical development, delamanid. In the present study, we compared the activities of PA-824 and TBA-354 as monotherapies in murine models of the initial intensive and continuation phases of treatment, as well as in combination with bedaquiline plus pyrazinamide, sutezolid, and/or clofazimine. The monotherapy studies demonstrated that TBA-354 is 5 to 10 times more potent than PA-824, but selected mutants are cross-resistant to PA-824 and delamanid. The combination studies revealed that TBA-354 is 2 to 4 times more potent than PA-824 when combined with bedaquiline, and when administered at a dose equivalent to that of PA-824, TBA-354 demonstrated superior sterilizing efficacy. Perhaps most importantly, the addition of either nitroimidazole significantly improved the sterilizing activities of bedaquiline and sutezolid, with or without pyrazinamide, confirming the value of each agent in this potentially universally active short-course regimen. Copyright © 2015, American Society for Microbiology. All Rights Reserved.

  18. 7 CFR 1901.505 - Certificates of beneficial ownership in FmHA or its successor agency under Public Law 103-354 loans.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 7 Agriculture 12 2011-01-01 2011-01-01 false Certificates of beneficial ownership in FmHA or its... ownership in FmHA or its successor agency under Public Law 103-354 loans. (a) Special trust of loans—(1) Establishment of special trusts. From time to time FmHA or its successor agency under Public Law 103-354 will...

  19. Deep subsurface life in Bengal Fan sediments (IODP Exp. 354)

    NASA Astrophysics Data System (ADS)

    Adhikari, R. R.; Heuer, V. B.; Elvert, M.; Kallmeyer, J.; Kitte, J. A.; Wörmer, L.; Hinrichs, K. U.

    2017-12-01

    We collected Bengal Fan sediment samples along a 8°N transect during International Ocean Discovery Program Expedition 354 (February - March 2015, Singapore - Colombo, Sri Lanka) to study subseafloor life in this, as yet unstudied, area. Among other biogeochemical parameters, we quantified microbial biomass by analyzing prokaryotic cells using epifluorescence microscopy after detaching cells from the sediment, and bacterial endospores by analyzing the diagnostic biomarker dipicolinic acid (DPA) by detection of fluorescence of the terbium-DPA complex. To gain understanding of total microbial activity, we quantified hydrogen utilization potential of hydrogenase enzymes, which are ubiquitous in subsurface microorganisms, by using a tritium assay. We measured highest cell concentrations of ca. 108 cells g-1 in shallow sediments close to the seafloor. These concentrations are one to two orders of magnitude lower than in most marine continental margin settings [1]. Similar to the global trend [1], cell concentrations decreased with depth according to a power-law function. Endospore concentrations scattered between ca. 105 and 107 cells g-1 sediment at all sites and depths. We could not observe a clear relationship of endospore concentration and sediment depth; instead, it appears to be linked to lithology and total organic carbon content. Bulk Hydrogenase enzyme activity ranged from nmolar to μmolar range of H2 g-1d-1. Similar to previous observations [2], per-cell hydrogen utilization depends on vertical biogeochemical zones, which could be due to the differences in hydrogen utilization requirements/efficiency of the respective metabolic processes such as sulfate reduction, methanogenesis, fermentation etc. Bengal fan is highly dynamic due to channel and levee systems and the sediments are dominated by turbidites, thick sand layers and hemipelagic deposits, which may control biogeochemical zonation. Based on our microbial biomass and activity data, we suggest that the

  20. An ecology of prestige in New York City: Examining the relationships among population density, socio-economic status, group identity, and residential canopy cover

    Treesearch

    J. Morgan Grove; Dexter H. Locke; Jarlath P.M. O' Neil-Dunne

    2014-01-01

    Several social theories have been proposed to explain the uneven distribution of vegetation in urban residential areas: population density, social stratification, luxury effect, and ecology of prestige. We evaluate these theories using a combination of demographic and socio-economic predictors of vegetative cover on all residential lands in New York City. We use...

  1. 7 CFR Exhibit C to Subpart E of... - FmHA or Its Successor Agency Under Public Law 103-354 Financed Contract

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 7 Agriculture 12 2011-01-01 2011-01-01 false FmHA or Its Successor Agency Under Public Law 103-354... Civil Rights Compliance Requirements Pt. 1901, Subpt. E, Exh. C Exhibit C to Subpart E of Part 1901—FmHA..., from exhibit E, FmHA or its successor agency under Public Law 103-354 Instruction 1901-E) We submit the...

  2. 29 CFR 1926.354 - Welding, cutting, and heating in way of preservative coatings.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 29 Labor 8 2010-07-01 2010-07-01 false Welding, cutting, and heating in way of preservative... Welding and Cutting § 1926.354 Welding, cutting, and heating in way of preservative coatings. (a) Before welding, cutting, or heating is commenced on any surface covered by a preservative coating whose...

  3. 29 CFR 1926.354 - Welding, cutting, and heating in way of preservative coatings.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 29 Labor 8 2012-07-01 2012-07-01 false Welding, cutting, and heating in way of preservative... Welding and Cutting § 1926.354 Welding, cutting, and heating in way of preservative coatings. (a) Before welding, cutting, or heating is commenced on any surface covered by a preservative coating whose...

  4. 29 CFR 1926.354 - Welding, cutting, and heating in way of preservative coatings.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 29 Labor 8 2014-07-01 2014-07-01 false Welding, cutting, and heating in way of preservative... Welding and Cutting § 1926.354 Welding, cutting, and heating in way of preservative coatings. (a) Before welding, cutting, or heating is commenced on any surface covered by a preservative coating whose...

  5. 29 CFR 1926.354 - Welding, cutting, and heating in way of preservative coatings.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 29 Labor 8 2011-07-01 2011-07-01 false Welding, cutting, and heating in way of preservative... Welding and Cutting § 1926.354 Welding, cutting, and heating in way of preservative coatings. (a) Before welding, cutting, or heating is commenced on any surface covered by a preservative coating whose...

  6. 29 CFR 1926.354 - Welding, cutting, and heating in way of preservative coatings.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 29 Labor 8 2013-07-01 2013-07-01 false Welding, cutting, and heating in way of preservative... Welding and Cutting § 1926.354 Welding, cutting, and heating in way of preservative coatings. (a) Before welding, cutting, or heating is commenced on any surface covered by a preservative coating whose...

  7. Integrating economy, ecology and uncertainty in an oil-spill DSS: The Prestige accident in Spain, 2002

    NASA Astrophysics Data System (ADS)

    Wirtz, Kai W.; Liu, Xin

    2006-12-01

    Major accidental oil spills still affect sensitive marine areas and shorelines around the world, constituting a challenge for operational as well as strategic contingency management. As a rationale basis for addressing both issues we here propose a Decision Support System (DSS) consisting of a combination of modelling and evaluation methods which in particular assesses various impacts on habitats and local economies. By integrating the state-of-the-art oil spill contingency simulation system OSCAR with wind and current forecasts, environmental GIS data and multi-criteria analysis techniques, the DSS is able to rank different response actions to a chemical or oil spill. In this study, the usefulness of the approach is tested by hindcasting the Prestige accident off the coast of Spain in 2002. In particular, the short- to mid-term economic and ecological consequences of different mitigation measures are estimated. We identified clearly one worst option matching the actual decision taken by the responsible parties and one or two almost equally well performing routes. Two procedures of including uncertainty at various stages of the DSS are tested. The first method averages ensembles of outcomes between each modelling/evaluation stage, while the second one preserves the entire degree of freedom till the final ranking procedure. Results in the Prestige case turned out to be rather insensitive against both ways to account for uncertainties. The robustness as well as clarity of the DSS has the potential to enhance the efficiency of decision making even in politically sensitive situations. Limitations as well as ongoing improvements of the system are highlighted, in particular emphasizing linkages to environmental economics.

  8. 7 CFR 1950.103 - Borrower owing FmHA or its successor agency under Public Law 103-354 loans which are secured by...

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 7 Agriculture 14 2010-01-01 2009-01-01 true Borrower owing FmHA or its successor agency under... owing FmHA or its successor agency under Public Law 103-354 loans which are secured by chattels. (a... actions to take in connection with the FmHA or its successor agency under Public Law 103-354 loan...

  9. 7 CFR 1950.103 - Borrower owing FmHA or its successor agency under Public Law 103-354 loans which are secured by...

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 7 Agriculture 14 2011-01-01 2011-01-01 false Borrower owing FmHA or its successor agency under... owing FmHA or its successor agency under Public Law 103-354 loans which are secured by chattels. (a... actions to take in connection with the FmHA or its successor agency under Public Law 103-354 loan...

  10. Cross-sectional Serosurvey of Crimean-Congo Hemorrhagic Fever Virus IgG in Livestock, India, 2013-2014.

    PubMed

    Mourya, Devendra T; Yadav, Pragya D; Shete, Anita M; Sathe, Padmakar S; Sarkale, Prasad C; Pattnaik, Bramhadev; Sharma, Gaurav; Upadhyay, Kamlesh J; Gosavi, Surekha; Patil, Deepak Y; Chaubal, Gouri Y; Majumdar, Triparna D; Katoch, Vishwa M

    2015-10-01

    We conducted a cross-sectional serosurvey of Crimean-Congo hemorrhagic fever (CCHF) among livestock in 22 states and 1 union territory of India. A total of 5,636 samples from bovines, sheep, and goats were screened for CCHF virus IgG. IgG was detected in 354 samples, indicating that this virus is widespread in this country.

  11. 7 CFR Exhibit C to Subpart G of... - Subordination by the Government for Use With Rural Housing Site Loans

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... Housing Site Loans C Exhibit C to Subpart G of Part 1822 Agriculture Regulations of the Department of..., Subpt. G, Exh. C Exhibit C to Subpart G of Part 1822—Subordination by the Government for Use With Rural... Public Law 103-354, U.S. Department of Agriculture. (42 U.S.C. 1480; delegation of authority by the...

  12. Changes in corticocortical and corticohippocampal network during absence seizures in WAG/Rij rats revealed with time varying Granger causality.

    PubMed

    Sysoeva, Marina V; Vinogradova, Lyudmila V; Kuznetsova, Galina D; Sysoev, Ilya V; van Rijn, Clementina M

    2016-11-01

    Spike-and-wave discharges (SWDs) recorded in the cortical EEGs of WAG/Rij rats are the hallmark for absence epilepsy in this model. Although this type of epilepsy was long regarded as a form of primary generalized epilepsy, it is now recognized that there is an initiation zone - the perioral region of the somatosensory cortex. However, networks involved in spreading the seizure are not yet fully known. Previously, the dynamics of coupling between different layers of the perioral cortical region and between these zones and different thalamic nuclei was studied in time windows around the SWDs, using nonlinear Granger causality. The aim of the present study was to investigate, using the same method, the coupling dynamics between different regions of the cortex and between these regions and the hippocampus. Local field potentials were recorded in the frontal, parietal, and occipital cortices and in the hippocampus of 19 WAG/Rij rats. To detect changes in coupling reliably in a short time window, in order to provide a good temporal resolution, the innovative adapted time varying nonlinear Granger causality method was used. Mutual information function was calculated in addition to validate outcomes. Results of both approaches were tested for significance. The SWD initiation process was revealed as an increase in intracortical interactions starting from 3.5s before the onset of electrographic seizure. The earliest preictal increase in coupling was directed from the frontal cortex to the parietal cortex. Then, the coupling became bidirectional, followed by the involvement of the occipital cortex (1.5s before SWD onset). There was no driving from any cortical region to hippocampus, but a slight increase in coupling from hippocampus to the frontoparietal cortex was observed just before SWD onset. After SWD onset, an abrupt drop in coupling in all studied pairs was observed. In most of the pairs, the decoupling rapidly disappeared, but driving force from hippocampus and

  13. Spatial and temporal trends of polycyclic aromatic hydrocarbons in wild mussels from the Cantabrian coast (N Spain) after the Prestige oil spill.

    PubMed

    Soriano, José Antonio; Viñas, Lucía; Franco, María Angeles; González, Juan José; Nguyen, Manh Hieu; Bayona, Josep María; Albaigés, Joan

    2007-09-01

    Polycyclic aromatic hydrocarbon (PAH) levels were determined in tissues of wild mussels (Mytilus galloprovincialis) collected at 17 stations along the Cantabrian coast (N Spain), from Navia (Asturias) to Fuenterrabía (Basque Country), in order to assess the extent of the environmental impact caused by the Prestige oil spill (November 13, 2002). Six sampling campaigns were carried out in April, June and November in 2003 and 2004. The comparison of PAH data with those obtained earlier in 2000 showed a widespread pyrolytic and petrogenic contamination and allowed an estimation, for the first time, of the background pollution in the region and identification of the chronic hotspots. The spatial distribution found in the first samples after the oil spill revealed the eastern area as the most affected due to the continuous arrival of fuel slicks since early summer 2003. Several stations in this area showed increased total PAH concentrations of up to 15 times the pre-spill levels, which did not recover until April 2004, more than one year after the accident. Molecular parameters within the aliphatic and aromatic fractions were determined to assess the presence of Prestige oil in these samples.

  14. 7 CFR Exhibit A to Subpart A of... - Notice to FmHA or its successor agency under Public Law 103-354 Borrowers

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 7 Agriculture 14 2011-01-01 2011-01-01 false Notice to FmHA or its successor agency under Public... Part 1951—Notice to FmHA or its successor agency under Public Law 103-354 Borrowers FmHA or its... statements through their local FmHA or its successor agency under Public Law 103-354 office. [54 FR 10270...

  15. 7 CFR Exhibit A to Subpart A of... - Notice to FmHA or its successor agency under Public Law 103-354 Borrowers

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 7 Agriculture 14 2010-01-01 2009-01-01 true Notice to FmHA or its successor agency under Public... Part 1951—Notice to FmHA or its successor agency under Public Law 103-354 Borrowers FmHA or its... statements through their local FmHA or its successor agency under Public Law 103-354 office. [54 FR 10270...

  16. 7 CFR 354.1 - Overtime work at border ports, sea ports, and airports.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 7 Agriculture 5 2010-01-01 2010-01-01 false Overtime work at border ports, sea ports, and airports... EXPORTS; AND USER FEES § 354.1 Overtime work at border ports, sea ports, and airports. (a)(1) Any person... of aircraft at airports of entry or other places of inspection as a consequence of the operation of...

  17. Using Nikola Tesla's Story and His Experiments as Presented in the Film "The Prestige" to Promote Scientific Inquiry: A Report of an Action Research Project

    ERIC Educational Resources Information Center

    Hadzigeorgiou, Yannis; Garganourakis, Vassilios

    2010-01-01

    This paper reports on an action research project undertaken with the primary aim of investigating the extent to which situations that evoke a sense of wonder can promote scientific inquiry. Given the intense interest, curiosity, and wonder that some students had begun to develop after seeing the film "The Prestige", a science teacher…

  18. The Mechanical Properties and In Vitro Biocompatibility of PM-Fabricated Ti-28Nb-35.4Zr Alloy for Orthopedic Implant Applications

    PubMed Central

    Xu, Wei; Li, Ming; Wen, Cuie; Lv, Shaomin; Liu, Chengcheng; Lu, Xin

    2018-01-01

    A biocompatible Ti-28Nb-35.4Zr alloy used as bone implant was fabricated through the powder metallurgy process. The effects of mechanical milling and sintering temperatures on the microstructure and mechanical properties were investigated systematically, before in vitro biocompatibility of full dense Ti-28Nb-35.4Zr alloy was evaluated by cytotoxicity tests. The results show that the mechanical milling and sintering temperatures have significantly effects on the density and mechanical properties of the alloys. The relative density of the alloy fabricated by the atomized powders at 1500 °C is only 83 ± 1.8%, while the relative density of the alloy fabricated by the ball-milled powders can rapidly reach at 96.4 ± 1.3% at 1500 °C. When the temperature was increased to 1550 °C, the alloy fabricated by ball-milled powders achieve full density (relative density is 98.1 ± 1.2%). The PM-fabricated Ti-28Nb-35.4Zr alloy by ball-milled powders at 1550 °C can achieve a wide range of mechanical properties, with a compressive yield strength of 1058 ± 35.1 MPa, elastic modulus of 50.8 ± 3.9 GPa, and hardness of 65.8 ± 1.5 HRA. The in vitro cytotoxicity test suggests that the PM-fabricated Ti-28Nb-35.4Zr alloy by ball-milled powders at 1550 °C has no adverse effects on MC3T3-E1 cells with cytotoxicity ranking of 0 grade, which is nearly close to ELI Ti-6Al-4V or CP Ti. These properties and the net-shape manufacturability makes PM-fabricated Ti-28Nb-35.4Zr alloy a low-cost, highly-biocompatible, Ti-based biomedical alloy. PMID:29601517

  19. The Mechanical Properties and In Vitro Biocompatibility of PM-Fabricated Ti-28Nb-35.4Zr Alloy for Orthopedic Implant Applications.

    PubMed

    Xu, Wei; Li, Ming; Wen, Cuie; Lv, Shaomin; Liu, Chengcheng; Lu, Xin; Qu, Xuanhui

    2018-03-30

    A biocompatible Ti-28Nb-35.4Zr alloy used as bone implant was fabricated through the powder metallurgy process. The effects of mechanical milling and sintering temperatures on the microstructure and mechanical properties were investigated systematically, before in vitro biocompatibility of full dense Ti-28Nb-35.4Zr alloy was evaluated by cytotoxicity tests. The results show that the mechanical milling and sintering temperatures have significantly effects on the density and mechanical properties of the alloys. The relative density of the alloy fabricated by the atomized powders at 1500 °C is only 83 ± 1.8%, while the relative density of the alloy fabricated by the ball-milled powders can rapidly reach at 96.4 ± 1.3% at 1500 °C. When the temperature was increased to 1550 °C, the alloy fabricated by ball-milled powders achieve full density (relative density is 98.1 ± 1.2%). The PM-fabricated Ti-28Nb-35.4Zr alloy by ball-milled powders at 1550 °C can achieve a wide range of mechanical properties, with a compressive yield strength of 1058 ± 35.1 MPa, elastic modulus of 50.8 ± 3.9 GPa, and hardness of 65.8 ± 1.5 HRA. The in vitro cytotoxicity test suggests that the PM-fabricated Ti-28Nb-35.4Zr alloy by ball-milled powders at 1550 °C has no adverse effects on MC3T3-E1 cells with cytotoxicity ranking of 0 grade, which is nearly close to ELI Ti-6Al-4V or CP Ti. These properties and the net-shape manufacturability makes PM-fabricated Ti-28Nb-35.4Zr alloy a low-cost, highly-biocompatible, Ti-based biomedical alloy.

  20. 7 CFR Exhibit E to Subpart K of... - Guide Letter to Delinquent FmHA or Its Successor Agency Under Public Law 103-354 Single Family...

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... Agency Under Public Law 103-354 Single Family Housing Loan Borrowers E Exhibit E to Subpart K of Part... Agency Under Public Law 103-354 Single Family Housing Loan Borrowers Dear (name of borrower): This is to.... Their counseling services include advice on debt levels and credit purchases, consumer and cost...

  1. 9 CFR 354.2 - Designation of official certificates, memoranda, marks, other identifications, and devices for...

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 9 Animals and Animal Products 2 2011-01-01 2011-01-01 false Designation of official certificates... Section 354.2 Animals and Animal Products FOOD SAFETY AND INSPECTION SERVICE, DEPARTMENT OF AGRICULTURE... means any symbol, stamp, label, or seal indicating that the product has been officially inspected and/or...

  2. 9 CFR 354.2 - Designation of official certificates, memoranda, marks, other identifications, and devices for...

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 9 Animals and Animal Products 2 2010-01-01 2010-01-01 false Designation of official certificates... Section 354.2 Animals and Animal Products FOOD SAFETY AND INSPECTION SERVICE, DEPARTMENT OF AGRICULTURE... means any symbol, stamp, label, or seal indicating that the product has been officially inspected and/or...

  3. When the appeal of a dominant leader is greater than a prestige leader

    PubMed Central

    Sivanathan, Niro

    2017-01-01

    Across the globe we witness the rise of populist authoritarian leaders who are overbearing in their narrative, aggressive in behavior, and often exhibit questionable moral character. Drawing on evolutionary theory of leadership emergence, in which dominance and prestige are seen as dual routes to leadership, we provide a situational and psychological account for when and why dominant leaders are preferred over other respected and admired candidates. We test our hypothesis using three studies, encompassing more than 140,000 participants, across 69 countries and spanning the past two decades. We find robust support for our hypothesis that under a situational threat of economic uncertainty (as exemplified by the poverty rate, the housing vacancy rate, and the unemployment rate) people escalate their support for dominant leaders. Further, we find that this phenomenon is mediated by participants’ psychological sense of a lack of personal control. Together, these results provide large-scale, globally representative evidence for the structural and psychological antecedents that increase the preference for dominant leaders over their prestigious counterparts. PMID:28607061

  4. The Relationship Between Core Members' Social Capital and Perceived and Externally Evaluated Prestige and Cooperation Among HIV/AIDS-Related Civil Society Organizations in China.

    PubMed

    Wang, Danni; Xu, Xiaoru; Mei, Guangliang; Ma, Ying; Chen, Ren; Qin, Xia; Hu, Zhi

    2017-03-01

    The purpose of this study was to investigate whether the core members' social capital was associated with individually perceived and externally evaluated prestige and cooperation among the HIV/AIDS-related civil society organizations (CSOs). To accomplish this, a cross-sectional study using multistage sampling was carried out in eight provinces of China. Data were collected from the 327 core members via questionnaires and self-evaluated performance of the respondents were evaluated and measured. The interviews were conducted with all core members and the supervisory staff of the local Centers for Disease Control and Prevention. Multivariate logistic regression analysis indicated that social support (adjusted odds ratio [a OR] = 1.87) and organizational commitment (a OR = 1.57) were significantly associated with a higher odds of prestige performance in self-evaluation. Furthermore, social support (a OR = 1.65), trust (a OR = 1.33), and organizational commitment (a OR = 1.52) were significantly correlated with cooperation performance. Trust was positively associated with the cooperation performance on external evaluation. These findings may provide a new perspective on challenges that the CSOs face in response to a growing HIV/AIDS epidemic in China. Social capital may increase performance and accelerate organizational growth, ultimately improving HIV/AIDS prevention and care.

  5. Follow-Up Genotoxic Study: Chromosome Damage Two and Six Years after Exposure to the Prestige Oil Spill

    PubMed Central

    Hildur, Kristin; Templado, Cristina; Zock, Jan-Paul; Giraldo, Jesús; Pozo-Rodríguez, Francisco; Frances, Alexandra; Monyarch, Gemma; Rodríguez-Trigo, Gema; Rodriguez-Rodriguez, Emma; Souto, Ana; Gómez, Federico P.; Antó, Josep M.; Barberà, Joan Albert; Fuster, Carme

    2015-01-01

    Background The north-west coast of Spain was heavily contaminated by the Prestige oil spill, in 2002. Individuals who participated in the clean-up tasks showed increased chromosome damage two years after exposure. Long-term clinical implications of chromosome damage are still unknown. Objective To realize a follow-up genotoxic study to detect whether the chromosome damage persisted six years after exposure to the oil. Design Follow-up study. Setting Fishermen cooperatives in coastal villages. Participants Local fishermen who were highly exposed (n = 52) and non-exposed (n = 23) to oil seven years after the spill. Measurements Chromosome damage in circulating lymphocytes. Results Chromosome damage in exposed individuals persists six years after oil exposure, with a similar incidence than those previously detected four years before. A surprising increase in chromosome damage in non-exposed individual was found six years after Prestige spill vs. those detected two years after the exposure. Limitations The sample size and the possibility of some kind of selection bias should be considered. Genotoxic results cannot be extrapolated to the approximately 300,000 individuals who participated occasionally in clean-up tasks. Conclusion The persistence of chromosome damage detected in exposed individuals six years after oil exposure seems to indicate that the cells of the bone marrow are affected. A surprising increase in chromosome damage in non-exposed individuals detected in the follow-up study suggests an indirect exposition of these individuals to some oil compounds or to other toxic agents during the last four years. More long-term studies are needed to confirm the presence of chromosome damage in exposed and non-exposed fishermen due to the association between increased chromosomal damage and increased risk of cancer. Understanding and detecting chromosome damage is important for detecting cancer in its early stages. The present work is the first follow-up cytogenetic

  6. 31 CFR 354.7 - Withdrawal of eligible Book-entry Sallie Mae Securities for conversion to definitive form.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 31 Money and Finance:Treasury 2 2011-07-01 2011-07-01 false Withdrawal of eligible Book-entry... PUBLIC DEBT REGULATIONS GOVERNING BOOK-ENTRY SECURITIES OF THE STUDENT LOAN MARKETING ASSOCIATION (SALLIE MAE) § 354.7 Withdrawal of eligible Book-entry Sallie Mae Securities for conversion to definitive form...

  7. Adherence to dietary guidelines for fruit, vegetables and fish among older Dutch adults; the role of education, income and job prestige.

    PubMed

    Dijkstra, S C; Neter, J E; Brouwer, I A; Huisman, M; Visser, M

    2014-01-01

    Little is known about socio-economic differences in dietary intake among older adults. In this study we describe self-reported dietary adherence to the fruit, vegetables and fish guidelines among older Dutch adults and investigate the independent associations of three socio-economic status (SES) indicators with adherence to these guidelines. Cross sectional data-analyses. The Longitudinal Aging Study Amsterdam (LASA), the Netherlands. 1057 community dwelling older adults, aged 55-85 years. Fruit, vegetable and fish intake was assessed using a short food frequency questionnaire. We measured SES using self-reported levels of education, household income and occupational prestige. 82.5% of the respondents reported to adhere to the fruit guideline, 65.1% to the vegetables guideline, and 31.7% to the fish guideline. After adjustment for confounders and the other two SES indicators, respondents in the lowest education group adhered less often to the vegetables guideline (OR 0.39 (95% CI 0.22-0.70)) compared to those in the highest education group. Respondents in the lowest income group adhered less often to the fruit (0.44 (95 % CI 0.22-0.91) and fish guideline (OR 0.55 (95% CI 0.33-0.91) compared to those in the highest groups. Occupational prestige was not independently associated with adherence any the guidelines. Self-reported adherence to the fruit, vegetables and fish guidelines among older adults can be improved and particularly in those with a low SES. Education and income have independent and unique contributions to dietary adherence. Future research should investigate potential pathways through which these specific SES indicators influence dietary adherence.

  8. 7 CFR Guide 1 to Subpart G of... - Project Management Agreement Between the ____ Regional Commission and the Farmers Home...

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 7 Agriculture 13 2010-01-01 2009-01-01 true Project Management Agreement Between the ____ Regional... Guide 1 to Subpart G of Part 1942—Project Management Agreement Between the ____ Regional Commission and... successor agency under Public Law 103-354, in concurring to this Project Management Agreement, hereby...

  9. Analyzing the Relationship of Geographic Mobility and Institutional Prestige to Career Advancement of Women in Academic Medicine Pursuing Midcareer-, Senior-, or Executive-Level Administrative Positions: Implications for Career Advancement Strategies

    ERIC Educational Resources Information Center

    McLean, Marsha Renee

    2010-01-01

    The purpose of this study was to explore the relationship of geographic mobility and institutional prestige to career advancement defined as administrative promotions of women seeking midcareer-, senior-, or executive-level positions at academic health centers (AHCs) and their medical schools or in non-AHC related medical schools in the United…

  10. Exogenous Ketone Supplements Reduce Anxiety-Related Behavior in Sprague-Dawley and Wistar Albino Glaxo/Rijswijk Rats

    PubMed Central

    Ari, Csilla; Kovács, Zsolt; Juhasz, Gabor; Murdun, Cem; Goldhagen, Craig R.; Koutnik, Andrew P.; Poff, Angela M.; Kesl, Shannon L.; D’Agostino, Dominic P.

    2016-01-01

    Nutritional ketosis has been proven effective for seizure disorders and other neurological disorders. The focus of this study was to determine the effects of ketone supplementation on anxiety-related behavior in Sprague-Dawley (SPD) and Wistar Albino Glaxo/Rijswijk (WAG/Rij) rats. We tested exogenous ketone supplements added to food and fed chronically for 83 days in SPD rats and administered sub-chronically for 7 days in both rat models by daily intragastric gavage bolus followed by assessment of anxiety measures on elevated plus maze (EPM). The groups included standard diet (SD) or SD + ketone supplementation. Low-dose ketone ester (LKE; 1,3-butanediol-acetoacetate diester, ~10 g/kg/day, LKE), high dose ketone ester (HKE; ~25 g/kg/day, HKE), beta-hydroxybutyrate-mineral salt (βHB-S; ~25 g/kg/day, KS) and βHB-S + medium chain triglyceride (MCT; ~25 g/kg/day, KSMCT) were used as ketone supplementation for chronic administration. To extend our results, exogenous ketone supplements were also tested sub-chronically on SPD rats (KE, KS and KSMCT; 5 g/kg/day) and on WAG/Rij rats (KE, KS and KSMCT; 2.5 g/kg/day). At the end of treatments behavioral data collection was conducted manually by a blinded observer and with a video-tracking system, after which blood βHB and glucose levels were measured. Ketone supplementation reduced anxiety on EPM as measured by less entries to closed arms (sub-chronic KE and KS: SPD rats and KSMCT: WAG/Rij rats), more time spent in open arms (sub-chronic KE: SPD and KSMCT: WAG/Rij rats; chronic KSMCT: SPD rats), more distance traveled in open arms (chronic KS and KSMCT: SPD rats) and by delayed latency to entrance to closed arms (chronic KSMCT: SPD rats), when compared to control. Our data indicates that chronic and sub-chronic ketone supplementation not only elevated blood βHB levels in both animal models, but reduced anxiety-related behavior. We conclude that ketone supplementation may represent a promising anxiolytic strategy through a

  11. An Ecology of Prestige in New York City: Examining the Relationships Among Population Density, Socio-economic Status, Group Identity, and Residential Canopy Cover

    NASA Astrophysics Data System (ADS)

    Grove, J. Morgan; Locke, Dexter H.; O'Neil-Dunne, Jarlath P. M.

    2014-09-01

    Several social theories have been proposed to explain the uneven distribution of vegetation in urban residential areas: population density, social stratification, luxury effect, and ecology of prestige. We evaluate these theories using a combination of demographic and socio-economic predictors of vegetative cover on all residential lands in New York City. We use diverse data sources including the City's property database, time-series demographic and socio-economic data from the US Census, and land cover data from the University of Vermont's Spatial Analysis Lab (SAL). These data are analyzed using a multi-model inferential, spatial econometrics approach. We also examine the distribution of vegetation within distinct market categories using Claritas' Potential Rating Index for Zipcode Markets (PRIZM™) database. These categories can be disaggregated, corresponding to the four social theories. We compare the econometric and categorical results for validation. Models associated with ecology of prestige theory are more effective for predicting the distribution of vegetation. This suggests that private, residential patterns of vegetation, reflecting the consumption of environmentally relevant goods and services, are associated with different lifestyles and lifestages. Further, our spatial and temporal analyses suggest that there are significant spatial and temporal dependencies that have theoretical and methodological implications for understanding urban ecological systems. These findings may have policy implications. Decision makers may need to consider how to most effectively reach different social groups in terms of messages and messengers in order to advance land management practices and achieve urban sustainability.

  12. An ecology of prestige in New York City: examining the relationships among population density, socio-economic status, group identity, and residential canopy cover.

    PubMed

    Grove, J Morgan; Locke, Dexter H; O'Neil-Dunne, Jarlath P M

    2014-09-01

    Several social theories have been proposed to explain the uneven distribution of vegetation in urban residential areas: population density, social stratification, luxury effect, and ecology of prestige. We evaluate these theories using a combination of demographic and socio-economic predictors of vegetative cover on all residential lands in New York City. We use diverse data sources including the City's property database, time-series demographic and socio-economic data from the US Census, and land cover data from the University of Vermont's Spatial Analysis Lab (SAL). These data are analyzed using a multi-model inferential, spatial econometrics approach. We also examine the distribution of vegetation within distinct market categories using Claritas' Potential Rating Index for Zipcode Markets (PRIZM™) database. These categories can be disaggregated, corresponding to the four social theories. We compare the econometric and categorical results for validation. Models associated with ecology of prestige theory are more effective for predicting the distribution of vegetation. This suggests that private, residential patterns of vegetation, reflecting the consumption of environmentally relevant goods and services, are associated with different lifestyles and lifestages. Further, our spatial and temporal analyses suggest that there are significant spatial and temporal dependencies that have theoretical and methodological implications for understanding urban ecological systems. These findings may have policy implications. Decision makers may need to consider how to most effectively reach different social groups in terms of messages and messengers in order to advance land management practices and achieve urban sustainability.

  13. 7 CFR 1980.495 - FmHA or its successor agency under Public Law 103-354 forms and guides.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... Disaster Assistance for Rural Business Enterprises” and Forms FmHA or its successor agency under Public Law 103-354 1980-71, “Lender's Agreement—Disaster Assistance for Rural Business Enterprises Guaranteed Loans,” 1980-72 “Loan Note Guarantee—Disaster Assistance for Rural Business Enterprises Guaranteed Loans...

  14. Remedial investigation report on Waste Area Grouping 5 at Oak Ridge National Laboratory, Oak Ridge, Tennessee. Volume 3 -- Appendix B: Technical findings and conclusions

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    NONE

    1995-09-01

    This document provides the Environmental Restoration Program with information about the results of investigations performed at Waste Area Grouping (WAG) 5. It includes information on risk assessments that have evaluated long-term impacts to human health and the environment. Information provided in this document forms the basis for decisions regarding the need for subsequent remediation work at WAG 5. Sections B1.1 through B1.4 present an overview of the environmental setting of WAG 5, including location, population, land uses, ecology, and climate, and Sects. B1.5 through B1.7 give site-specific details (e.g., topography, soils, geology, and hydrology). The remediation investigation (RI) of WAGmore » 5 did not entail en exhaustive characterization of all physical attributes of the site; the information presented here focuses on those most relevant to the development and verification of the WAG 5 conceptual model. Most of the information presented in this appendix was derived from the RI field investigation, which was designed to complement the existing data base from earlier, site-specific studies of Solid Waste Storage Area (SWSA) 5 and related areas.« less

  15. 75 FR 3159 - Corporate Reorganizations; Distributions Under Sections 368(a)(1)(D) and 354(b)(1)(B); Correction

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-01-20

    ... DEPARTMENT OF THE TREASURY Internal Revenue Service 26 CFR Part 1 [TD 9475] RIN 1545-BF83 Corporate Reorganizations; Distributions Under Sections 368(a)(1)(D) and 354(b)(1)(B); Correction AGENCY... transactions as reorganizations described in section 368(a)(1)(D) where no stock and/or securities of the...

  16. 7 CFR 1980.495 - FmHA or its successor agency under Public Law 103-354 forms and guides.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... for Drought and Disaster Relief” and Forms FmHA or its successor agency under Public Law 103-354 1980-68, “Lender's Agreement—Drought and Disaster Guaranteed Loans,” 1980-69, “Loan Note Guarantee—Drought and Disaster Guaranteed Loans,” and 1980-70, “Assignment Guarantee Agreement—Drought and Disaster...

  17. 7 CFR 1980.495 - FmHA or its successor agency under Public Law 103-354 forms and guides.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... for Drought and Disaster Relief” and Forms FmHA or its successor agency under Public Law 103-354 1980-68, “Lender's Agreement—Drought and Disaster Guaranteed Loans,” 1980-69, “Loan Note Guarantee—Drought and Disaster Guaranteed Loans,” and 1980-70, “Assignment Guarantee Agreement—Drought and Disaster...

  18. 7 CFR 1980.495 - FmHA or its successor agency under Public Law 103-354 forms and guides.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... for Drought and Disaster Relief” and Forms FmHA or its successor agency under Public Law 103-354 1980-68, “Lender's Agreement—Drought and Disaster Guaranteed Loans,” 1980-69, “Loan Note Guarantee—Drought and Disaster Guaranteed Loans,” and 1980-70, “Assignment Guarantee Agreement—Drought and Disaster...

  19. 7 CFR 1980.495 - FmHA or its successor agency under Public Law 103-354 forms and guides.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... for Drought and Disaster Relief” and Forms FmHA or its successor agency under Public Law 103-354 1980-68, “Lender's Agreement—Drought and Disaster Guaranteed Loans,” 1980-69, “Loan Note Guarantee—Drought and Disaster Guaranteed Loans,” and 1980-70, “Assignment Guarantee Agreement—Drought and Disaster...

  20. 76 FR 49300 - Corporate Reorganizations; Distributions Under Sections 368(a)(1)(D) and 354(b)(1)(B); Correction

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-08-10

    ... Corporate Reorganizations; Distributions Under Sections 368(a)(1)(D) and 354(b)(1)(B); Correction AGENCY... in section 368(a)(1)(D) where no stock and/or securities of the acquiring corporation is issued and... guidance regarding the determination of the basis of stock or securities in a reorganization described in...

  1. Why do households invest in sanitation in rural Benin: Health, wealth, or prestige?

    NASA Astrophysics Data System (ADS)

    Gross, Elena; Günther, Isabel

    2014-10-01

    Seventy percent of the rural population in sub-Saharan Africa does not use adequate sanitation facilities. In rural Benin, as much as 95% of the population does not use improved sanitation. By analyzing a representative sample of 2000 rural households, this paper explores why households remain without latrines. Our results show that wealth and latrine prices play the most decisive role for sanitation demand and ownership. At current income levels, sanitation coverage will only increase to 50% if costs for construction are reduced from currently 190 USD to 50 USD per latrine. Our analysis also suggests that previous sanitation campaigns, which were based on prestige and the allure of a modern lifestyle as motives for latrine construction, have had no success in increasing sanitation coverage. Moreover, improved public health, which is the objective of public policies promoting sanitation, will not be effective at low sanitation coverage rates. Fear at night, especially of animals, and personal harassment, are stated as the most important motivational factors for latrine ownership and the intention to build one. We therefore suggest changing the message of sanitation projects and introduce new low-cost technologies into rural markets; otherwise, marketing strategies will continue to fail in increasing sanitation demand.

  2. 75 FR 3160 - Corporate Reorganizations; Distributions Under Sections 368(a)(1)(D) and 354(b)(1)(B); Correction

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-01-20

    ... DEPARTMENT OF THE TREASURY Internal Revenue Service 26 CFR Part 1 [TD 9475] RIN 1545-BF83 Corporate Reorganizations; Distributions Under Sections 368(a)(1)(D) and 354(b)(1)(B); Correction AGENCY... reorganizations described in section 368(a)(1)(D) where no stock and/or securities of the acquiring corporation is...

  3. The tale wagged by the DAG: broadening the scope of causal inference and explanation for epidemiology.

    PubMed

    Krieger, Nancy; Davey Smith, George

    2016-12-01

    'Causal inference', in 21st century epidemiology, has notably come to stand for a specific approach, one focused primarily on counterfactual and potential outcome reasoning and using particular representations, such as directed acyclic graphs (DAGs) and Bayesian causal nets. In this essay, we suggest that in epidemiology no one causal approach should drive the questions asked or delimit what counts as useful evidence. Robust causal inference instead comprises a complex narrative, created by scientists appraising, from diverse perspectives, different strands of evidence produced by myriad methods. DAGs can of course be useful, but should not alone wag the causal tale. To make our case, we first address key conceptual issues, after which we offer several concrete examples illustrating how the newly favoured methods, despite their strengths, can also: (i) limit who and what may be deemed a 'cause', thereby narrowing the scope of the field; and (ii) lead to erroneous causal inference, especially if key biological and social assumptions about parameters are poorly conceived, thereby potentially causing harm. As an alternative, we propose that the field of epidemiology consider judicious use of the broad and flexible framework of 'inference to the best explanation', an approach perhaps best developed by Peter Lipton, a philosopher of science who frequently employed epidemiologically relevant examples. This stance requires not only that we be open to being pluralists about both causation and evidence but also that we rise to the challenge of forging explanations that, in Lipton's words, aspire to 'scope, precision, mechanism, unification and simplicity'. © The Author 2016; all rights reserved. Published by Oxford University Press on behalf of the International Epidemiological Association.

  4. 7 CFR 1948.89 - Land condemnation by FmHA or its successor agency under Public Law 103-354.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 7 Agriculture 13 2011-01-01 2009-01-01 true Land condemnation by FmHA or its successor agency... DEVELOPMENT Section 601 Energy Impacted Area Development Assistance Program § 1948.89 Land condemnation by FmHA or its successor agency under Public Law 103-354. (a) If FmHA or its successor agency under Public...

  5. 7 CFR 1948.89 - Land condemnation by FmHA or its successor agency under Public Law 103-354.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 7 Agriculture 13 2010-01-01 2009-01-01 true Land condemnation by FmHA or its successor agency... DEVELOPMENT Section 601 Energy Impacted Area Development Assistance Program § 1948.89 Land condemnation by FmHA or its successor agency under Public Law 103-354. (a) If FmHA or its successor agency under Public...

  6. 7 CFR 1944.548 - Counseling consent by FmHA or its successor agency under Public Law 103-354 single family housing...

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... grantee (at no cost) the borrower's FmHA or its successor agency under Public Law 103-354 loan history... including the amount of the loan, the repayment schedule, and the amount of the delinquency; and (3) Other...

  7. Arg354 in the catalytic centre of bovine liver catalase is protected from methylglyoxal-mediated glycation.

    PubMed

    Scheckhuber, Christian Q

    2015-12-30

    In addition to controlled post-translational modifications proteins can be modified with highly reactive compounds. Usually this leads to a compromised functionality of the protein. Methylglyoxal is one of the most common agents that attack arginine residues. Methylglyoxal is also regarded as a pro-oxidant that affects cellular redox homeostasis by contributing to the formation of reactive oxygen species. Antioxidant enzymes like catalase are required to protect the cell from oxidative damage. These enzymes are also targets for methylglyoxal-mediated modification which could severely affect their catalytic activity in breaking down reactive oxygen species to less reactive or inert compounds. Here, bovine liver catalase was incubated with high levels of methylglyoxal to induce its glycation. This treatment did not lead to a pronounced reduction of enzymatic activity. Subsequently methylglyoxal-mediated arginine modifications (hydroimidazolone and dihydroxyimidazolidine) were quantitatively analysed by sensitive nano high performance liquid chromatography/electron spray ionisation/tandem mass spectrometry. Whereas several arginine residues displayed low to moderate levels of glycation (e.g., Arg93, Arg365, Arg444) Arg354 in the active centre of catalase was never found to be modified. Bovine liver catalase is able to tolerate very high levels of the modifying α-oxoaldehyde methylglyoxal so that its essential enzymatic function is not impaired.

  8. Undergraduate Collaborative Research: Distribution of Plant Wax Biomarkers in Miocene-age Sediments from the Bengal Fan (IODP Exp 354)

    NASA Astrophysics Data System (ADS)

    Cho, P. G.; Vidal, E.; Paek, J. H.; Borsook, A.; Lee, W.; Wu, M. S.; Ponton, C.; Galy, V.; Feakins, S. J.

    2017-12-01

    Our research aims to understand past climatic variability in the monsoon-influenced Ganges-Brahmaputra catchment as recorded by plant wax molecules exported and sequestered in the sediments of the Bengal Fan. Samples from the late Miocene were selected from cores retrieved by the IODP (International Ocean Discovery Program) Expedition 354 that recently drilled the central Bengal Fan along a transect at 8°N. Fan sedimentation includes sand, silt, and clay mostly derived from the Himalayan range via turbiditic transport within the Bengal fan. Sedimentation is highly episodic in the fan, but a transect of drilled sites provides a record of terrigenous sediment exported and buried over the last 20 million years. A team of researchers at the University of Southern California worked to collectively process 468 samples for compound specific biomarker identification and quantification. The samples derive from Site U1451 and U1455 ranging from 0 to 1097m depth (CSF-A). Total organic carbon ranges from 0.04-0.84%. To date, 300 samples have been solvent-extracted and prepared for plant wax analyses. Long chain n-alkanoic acids and n-alkanes were identified and quantified using GC-MS and GC-FID, respectively. In the samples quantified so far, we find ΣC24-34 n-alkanoic acid concentrations from 0.07-14.16 μg/g of dry sediment and ΣC25-35 n-alkanes from 0.04-4.61 μg/g. Concentrations of C30 n-alkanoic acid range from 0.01-1.92 μg/g of dry sediment and of C33 n-alkane from <0.01-0.65 μg/g. The molecular abundance distributions of both compound-classes were found to be diagnostic of a terrestrial higher plant source. Additionally, the molecular composition of the total lipid extract was analyzed at the Woods Hole Oceanographic Institution using a GC-TOF-MS. Overall, these extracts are dominated by plant-wax compounds and other diagnostic terrestrial molecules (e.g. plant terpenoids and sterols). The results from this effort contribute to a larger mission to reconstruct

  9. The Prestige crisis: operational oceanography applied to oil recovery, by the Basque fishing fleet.

    PubMed

    González, Manuel; Uriarte, Adolfo; Pozo, Rogelio; Collins, Michael

    2006-01-01

    On 19th November 2002, the oil tanker Prestige (containing 77,000 tonnes of heavy fuel no. 2 (M100)) sank in 3500 m of water, off the coast of northwestern Spain. Intermittent discharge of oil from the stricken tanker, combined with large-scale sea surface dispersion, created a tracking and recovery problem. Initially, conventional oil recovery approaches were adopted, close to the wreck. With time and distance from the source, the oil dispersed dramatically and became less viscous. Consequently, a unique monitoring, prediction and data dissemination system was established, based upon the principles of 'operational oceanography'; this utilised in situ tracked buoys and numerical (spill trajectory) modelling outputs, in combination with remote sensing (satellite sensors and visual observation). Overall, wind effects on the surface waters were found to be the most important mechanism controlling the smaller oil slick movements. The recovery operation involved up to 180 fishing boats, 9-30 m in length. Such labour-intensive recovery of the oil (21,000 tonnes, representing an unprecedented ratio of 6.6 tonnes at sea, per tonne recovered on land) continued over a 10 month period. The overall recovery at sea, by the fishing vessels, represented 63% of the total oil recovered at sea; this compares to only 37% recovered by specialised 'counter- pollution' vessels.

  10. 7 CFR 1945.25 - Relationship between FmHA or its successor agency under Public Law 103-354 and FEMA.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 7 Agriculture 13 2011-01-01 2009-01-01 true Relationship between FmHA or its successor agency...) EMERGENCY Disaster Assistance-General § 1945.25 Relationship between FmHA or its successor agency under... FmHA or its successor agency under Public Law 103-354 on losses and damages caused by an unusual and...

  11. Cholinesterase and glutathione S-transferase activities of three mollusc species from the NW Portuguese coast in relation to the 'Prestige' oil spill.

    PubMed

    Tim-Tim, Ana L S; Morgado, Fernando; Moreira, Susana; Rangel, Rui; Nogueira, António J A; Soares, Amadeu M V M; Guilhermino, Lúcia

    2009-12-01

    In November 2002, the tanker 'Prestige' released about 19,000 tonnes of a heavy fuel oil (no. 6) before sinking with about 58,000 tonnes of its cargo, 135 miles from Cabo Finisterra (Spain). A considerable part of the released fuel oil reached the Galician coast, causing a heavy black tide and an ecological disaster. Although the black tide did not reach the NW coast of Portugal, it is possible that some of the fuel oil or its components also arrived to this area directly through the sea water and/or indirectly through the food chain. Therefore, the aim of this study was to investigate possible changes in two widely used biomarkers, the activity of the enzymes cholinesterases (ChE) and glutathione S-transferases (GST), of three molluscs (Mytilus galloprovincialis, Nucella lapillus and Monodonta lineata) from wild populations of the NW Portuguese coast in relation to the 'Prestige' oil spill. Molluscs were collected seasonally before (autumn 2002) and after (winter 2002/2003), spring and summer 2003) the oil spill at several sites along the Portuguese NW coast. Enzymatic activities determined before the accident were compared with those determined at different times after the oil spill taking into consideration abiotic factors. Information from different parameters was integrated by Redundancy Analysis and Principal Response Curves (PRC). Results show that GST and ChE activities were influenced by abiotic factors. Despite this influence, the results of PRC analysis also suggest that some of the fuel oil reached the NW Portuguese coast changing the patterns of ChE and GST activities of local populations of rocky shore species. Furthermore, the present study highlights the need of long-term monitoring with wild populations to assess both historical and punctual effects of pollution in the marine environment.

  12. H.E.S.S. discovery of very high energy γ-ray emission from PKS 0625-354

    NASA Astrophysics Data System (ADS)

    H.E.S.S. Collaboration; Abdalla, H.; Abramowski, A.; Aharonian, F.; Ait Benkhali, F.; Akhperjanian, A. G.; Andersson, T.; Angüner, E. O.; Arrieta, M.; Aubert, P.; Backes, M.; Balzer, A.; Barnard, M.; Becherini, Y.; Becker Tjus, J.; Berge, D.; Bernhard, S.; Bernlöhr, K.; Blackwell, R.; Böttcher, M.; Boisson, C.; Bolmont, J.; Bordas, P.; Bregeon, J.; Brun, F.; Brun, P.; Bryan, M.; Bulik, T.; Capasso, M.; Carr, J.; Casanova, S.; Cerruti, M.; Chakraborty, N.; Chalme-Calvet, R.; Chaves, R. C. G.; Chen, A.; Chevalier, J.; Chrétien, M.; Colafrancesco, S.; Cologna, G.; Condon, B.; Conrad, J.; Cui, Y.; Davids, I. D.; Decock, J.; Degrange, B.; Deil, C.; Devin, J.; deWilt, P.; Dirson, L.; Djannati-Ataï, A.; Domainko, W.; Donath, A.; Drury, L. O'C.; Dubus, G.; Dutson, K.; Dyks, J.; Dyrda, M.; Edwards, T.; Egberts, K.; Eger, P.; Ernenwein, J.-P.; Eschbach, S.; Farnier, C.; Fegan, S.; Fernandes, M. V.; Fiasson, A.; Fontaine, G.; Förster, A.; Funk, S.; Füßling, M.; Gabici, S.; Gajdus, M.; Gallant, Y. A.; Garrigoux, T.; Giavitto, G.; Giebels, B.; Glicenstein, J. F.; Gottschall, D.; Goyal, A.; Grondin, M.-H.; Hadasch, D.; Hahn, J.; Haupt, M.; Hawkes, J.; Heinzelmann, G.; Henri, G.; Hermann, G.; Hervet, O.; Hinton, J. A.; Hofmann, W.; Hoischen, C.; Holler, M.; Horns, D.; Ivascenko, A.; Jacholkowska, A.; Jamrozy, M.; Janiak, M.; Jankowsky, D.; Jankowsky, F.; Jingo, M.; Jogler, T.; Jouvin, L.; Jung-Richardt, I.; Kastendieck, M. A.; Katarzyński, K.; Katz, U.; Kerszberg, D.; Khélifi, B.; Kieffer, M.; King, J.; Klepser, S.; Klochkov, D.; Kluźniak, W.; Kolitzus, D.; Komin, Nu; Kosack, K.; Krakau, S.; Kraus, M.; Krayzel, F.; Krüger, P. P.; Laffon, H.; Lamanna, G.; Lau, J.; Lees, J.-P.; Lefaucheur, J.; Lefranc, V.; Lemière, A.; Lemoine-Goumard, M.; Lenain, J.-P.; Leser, E.; Lohse, T.; Lorentz, M.; Liu, R.; López-Coto, R.; Lypova, I.; Marandon, V.; Marcowith, A.; Mariaud, C.; Marx, R.; Maurin, G.; Maxted, N.; Mayer, M.; Meintjes, P. J.; Meyer, M.; Mitchell, A. M. W.; Moderski, R.; Mohamed, M.; Mohrmann, L.; Morâ, K.; Moulin, E.; Murach, T.; de Naurois, M.; Niederwanger, F.; Niemiec, J.; Oakes, L.; O'Brien, P.; Odaka, H.; Öttl, S.; Ohm, S.; Ostrowski, M.; Oya, I.; Padovani, M.; Panter, M.; Parsons, R. D.; Pekeur, N. W.; Pelletier, G.; Perennes, C.; Petrucci, P.-O.; Peyaud, B.; Piel, Q.; Pita, S.; Poon, H.; Prokhorov, D.; Prokoph, H.; Pühlhofer, G.; Punch, M.; Quirrenbach, A.; Raab, S.; Reimer, A.; Reimer, O.; Renaud, M.; de los Reyes, R.; Rieger, F.; Romoli, C.; Rosier-Lees, S.; Rowell, G.; Rudak, B.; Rulten, C. B.; Sahakian, V.; Salek, D.; Sanchez, D. A.; Santangelo, A.; Sasaki, M.; Schlickeiser, R.; Schüssler, F.; Schulz, A.; Schwanke, U.; Schwemmer, S.; Settimo, M.; Seyffert, A. S.; Shafi, N.; Shilon, I.; Simoni, R.; Sol, H.; Spanier, F.; Spengler, G.; Spies, F.; Stawarz, Ł.; Steenkamp, R.; Stegmann, C.; Stinzing, F.; Stycz, K.; Sushch, I.; Tavernet, J.-P.; Tavernier, T.; Taylor, A. M.; Terrier, R.; Tibaldo, L.; Tiziani, D.; Tluczykont, M.; Trichard, C.; Tuffs, R.; Uchiyama, Y.; van der Walt, D. J.; van Eldik, C.; van Rensburg, C.; van Soelen, B.; Vasileiadis, G.; Veh, J.; Venter, C.; Viana, A.; Vincent, P.; Vink, J.; Voisin, F.; Völk, H. J.; Vuillaume, T.; Wadiasingh, Z.; Wagner, S. J.; Wagner, P.; Wagner, R. M.; White, R.; Wierzcholska, A.; Willmann, P.; Wörnlein, A.; Wouters, D.; Yang, R.; Zabalza, V.; Zaborov, D.; Zacharias, M.; Zanin, R.; Zdziarski, A. A.; Zech, A.; Zefi, F.; Ziegler, A.; Żywucka, N.

    2018-05-01

    PKS 0625-354 (z = 0.055) was observed with the four High Energy Stereoscopic System (H.E.S.S.) telescopes in 2012 during 5.5 h. The source was detected above an energy threshold of 200 GeV at a significance level of 6.1σ. No significant variability is found in these observations. The source is well described with a power-law spectrum with photon index Γ = 2.84 ± 0.50stat ± 0.10syst and normalization (at E0 = 1.0 TeV) N0(E0) = (0.58 ± 0.22stat ± 0.12syst) × 10-12 TeV-1 cm-2 s-1. Multiwavelength data collected with Fermi-LAT, Swift-XRT, Swift-UVOT, ATOM and WISE are also analysed. Significant variability is observed only in the Fermi-LAT γ-ray and Swift-XRT X-ray energy bands. Having a good multiwavelength coverage from radio to very high energy, we performed a broad-band modelling from two types of emission scenarios. The results from a one zone lepto-hadronic and a multizone leptonic models are compared and discussed. On the grounds of energetics, our analysis favours a leptonic multizone model. Models associated to the X-ray variability constraint support previous results, suggesting a BL Lac nature of PKS 0625-354 with, however, a large-scale jet structure typical of a radio galaxy.

  13. 7 CFR 1948.88 - Direct land acquisition by FmHA or its successor agency under Public Law 103-354.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 7 Agriculture 13 2011-01-01 2009-01-01 true Direct land acquisition by FmHA or its successor... by FmHA or its successor agency under Public Law 103-354. (a) FmHA or its successor agency under... Governor of the State in which the real property is located. FmHA or its successor agency under Public Law...

  14. 7 CFR 1945.28 - Relationship between ASCS and FmHA or its successor agency under Public Law 103-354.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 7 Agriculture 13 2011-01-01 2009-01-01 true Relationship between ASCS and FmHA or its successor...) EMERGENCY Disaster Assistance-General § 1945.28 Relationship between ASCS and FmHA or its successor agency under Public Law 103-354. Exhibit A of FmHA Instruction 2000-JJ (a copy of which is available in any Fm...

  15. 7 CFR 1945.27 - Relationship between FCIC and FmHA or its successor agency under Public Law 103-354.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 7 Agriculture 13 2011-01-01 2009-01-01 true Relationship between FCIC and FmHA or its successor...) EMERGENCY Disaster Assistance-General § 1945.27 Relationship between FCIC and FmHA or its successor agency under Public Law 103-354. (a) General. Exhibit A of FmHA Instruction 2000-N (available in any FmHA or...

  16. 7 CFR 1948.88 - Direct land acquisition by FmHA or its successor agency under Public Law 103-354.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 7 Agriculture 13 2010-01-01 2009-01-01 true Direct land acquisition by FmHA or its successor... by FmHA or its successor agency under Public Law 103-354. (a) FmHA or its successor agency under... Governor of the State in which the real property is located. FmHA or its successor agency under Public Law...

  17. Isoflurane waste anesthetic gas concentrations associated with the open-drop method.

    PubMed

    Taylor, Douglas K; Mook, Deborah M

    2009-01-01

    The open-drop technique is used frequently for anesthetic delivery to small rodents. Operator exposure to waste anesthetic gas (WAG) is a potential occupational hazard if this method is used without WAG scavenging. This study was conducted to determine whether administration of isoflurane by the open-drop technique without exposure controls generates significant WAG concentrations. We placed 0.1, 0.2, or 0.3 ml of liquid isoflurane into screw-top 500 or 1000 ml glass jars. WAG concentration was measured at the opening of the container and 20 and 40 cm from the opening, a distance at which users likely would operate, at 1, 2, or 3 min WAG was measured by using a portable infrared gas analyzer. Mean WAG concentrations at the vessel opening were as high as 662 +/- 168 ppm with a 500 ml jar and 122 +/- 87 ppm with a 1000 ml jar. At operator levels, WAG concentrations were always at or near 0 ppm. For measurements made at the vessel opening, time was the only factor that significantly affected WAG concentration when using the 500 ml jar. Neither time nor liquid volume were significant factors when using 1000 ml jar. At all liquid volumes and time points, the WAG concentration associated with using the 500 ml container was marginally to significantly greater than that for the 1000 ml jar.

  18. Clinical and radiographic analysis of an artificial cervical disc: 7-year follow-up from the Prestige prospective randomized controlled clinical trial: Clinical article.

    PubMed

    Burkus, J Kenneth; Traynelis, Vincent C; Haid, Regis W; Mummaneni, Praveen V

    2014-10-01

    The authors assess the long-term safety and efficacy of cervical disc replacement with the Prestige Cervical Disc in a prospective, randomized, multicenter trial at 7 years of follow-up. At 31 investigational sites, 541 patients with single-level cervical disc disease with radiculopathy were randomized to 1 of 2 treatment groups: 276 investigational group patients underwent anterior cervical discectomy and arthroplasty with the Prestige disc, and 265 control group patients underwent anterior cervical discectomy and fusion. Clinical outcomes included Neck Disability Index, the 36-Item Short-Form Health Survey, and neck and arm pain scores. Radiographs were assessed for angle of motion and fusion. Clinical and radiographic outcomes were evaluated preoperatively, intraoperatively, and at 1.5, 3, 6, 12, 24, 36, 60, and 84 months. Of the 541 patients treated, 395 patients (73%; 212 investigational and 183 control patients) completed 7 years of clinical follow-up. Significant improvements achieved by 1.5 months in both groups were sustained at 7 years. In the investigational group, mean Neck Disability Index improvements from preoperative scores were 38.2 and 37.5 at 60 and 84 months, respectively. In the control group, the corresponding means were 33.8 and 31.9. The differences between the investigational and control groups at the 60-month and 84-month periods were significant (p = 0.014 and 0.002, respectively). The overall rates of maintenance or improvement in neurological status in the investigational group were significantly higher: 92.2% and 88.2% at 60 months and 84 months, respectively, compared with 85.7% and 79.7% in the control group (p = 0.017 and 0.011, respectively). At 84 months, the percentage of working patients in the investigational group was 73.9%, and in the control group, 73.1%. Postoperatively, the implant effectively maintained average angular motion of 6.67° at 60 months and 6.75° at 84 months. Cumulative rates for surgery at the index level

  19. 7 CFR 1940.335 - Environmental review of FmHA or its successor agency under Public Law 103-354 proposals for...

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 7 Agriculture 13 2010-01-01 2009-01-01 true Environmental review of FmHA or its successor agency... REGULATIONS (CONTINUED) GENERAL Environmental Program § 1940.335 Environmental review of FmHA or its successor... subpart, all FmHA or its successor agency under Public Law 103-354 proposals for legislation will receive...

  20. 7 CFR 1940.335 - Environmental review of FmHA or its successor agency under Public Law 103-354 proposals for...

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 7 Agriculture 13 2011-01-01 2009-01-01 true Environmental review of FmHA or its successor agency... REGULATIONS (CONTINUED) GENERAL Environmental Program § 1940.335 Environmental review of FmHA or its successor... subpart, all FmHA or its successor agency under Public Law 103-354 proposals for legislation will receive...

  1. 9 CFR 317.354 - Nutrient content claims for “good source,” “high,” and “more.”

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 9 Animals and Animal Products 2 2011-01-01 2011-01-01 false Nutrient content claims for âgood... Nutrition Labeling § 317.354 Nutrient content claims for “good source,” “high,” and “more.” (a) General... nutrient content claims in § 317.313; and (3) The product for which the claim is made is labeled in...

  2. Evaluation of PAH bioaccumulation and DNA damage in mussels (Mytilus galloprovincialis) exposed to spilled Prestige crude oil.

    PubMed

    Pérez-Cadahía, Beatriz; Laffon, Blanca; Pásaro, Eduardo; Méndez, Josefina

    2004-08-01

    We analyzed the hydrocarbon composition of the Prestige oil as it reached the shores, its solubility in sea water, its bioaccumulation, and the genotoxic damage associated to oil exposure, using Mytilus galloprovincialis as sentinel organism. Mussels were exposed to two oil volumetric ratios (1:500 and 2:500) for 12 days. Great concentrations of total polycyclic aromatic hydrocarbons (TPAH) have been obtained, being in general higher in the samples from the dose of 1:500, both in sea water (55.14 vs. 41.96 microg/l) and mussel tissue (16,993.80 vs. 17,033.00 microg/kg), probably due to the great tendency of these compounds to link to particles in water. Comet assay results reflected an increase in the DNA damage associated to oil exposure, higher in the mussels exposed to the higher aqueous TPAH content. In the view of our results, the importance of the evaluation of biodisponibility, bioaccumulation and DNA damage in the assessment of the effects of xenobiotic pollutants to marine environments could be highlighted.

  3. [Occupational hazards, DNA damage, and oxidative stress on exposure to waste anesthetic gases].

    PubMed

    Lucio, Lorena M C; Braz, Mariana G; do Nascimento Junior, Paulo; Braz, José Reinaldo C; Braz, Leandro G

    The waste anesthetic gases (WAGs) present in the ambient air of operating rooms (OR), are associated with various occupational hazards. This paper intends to discuss occupational exposure to WAGs and its impact on exposed professionals, with emphasis on genetic damage and oxidative stress. Despite the emergence of safer inhaled anesthetics, occupational exposure to WAGs remains a current concern. Factors related to anesthetic techniques and anesthesia workstations, in addition to the absence of a scavenging system in the OR, contribute to anesthetic pollution. In order to minimize the health risks of exposed professionals, several countries have recommended legislation with maximum exposure limits. However, developing countries still require measurement of WAGs and regulation for occupational exposure to WAGs. WAGs are capable of inducing damage to the genetic material, such as DNA damage assessed using the comet assay and increased frequency of micronucleus in professionals with long-term exposure. Oxidative stress is also associated with WAGs exposure, as it induces lipid peroxidation, oxidative damage in DNA, and impairment of the antioxidant defense system in exposed professionals. The occupational hazards related to WAGs including genotoxicity, mutagenicity and oxidative stress, stand as a public health issue and must be acknowledged by exposed personnel and responsible authorities, especially in developing countries. Thus, it is urgent to stablish maximum safe limits of concentration of WAGs in ORs and educational practices and protocols for exposed professionals. Copyright © 2017 Sociedade Brasileira de Anestesiologia. Publicado por Elsevier Editora Ltda. All rights reserved.

  4. 7 CFR 1901.506 - Book-entry procedure for FmHA or its successor agency under Public Law 103-354 securities...

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 7 Agriculture 12 2011-01-01 2011-01-01 false Book-entry procedure for FmHA or its successor agency... and Insured Notes § 1901.506 Book-entry procedure for FmHA or its successor agency under Public Law...) Issue book-entry FmHA or its successor agency under Public Law 103-354 securities by means of entries on...

  5. Polyphasic approach for assessing changes in an autochthonous marine bacterial community in the presence of Prestige fuel oil and its biodegradation potential.

    PubMed

    Jiménez, Núria; Viñas, Marc; Guiu-Aragonés, Cèlia; Bayona, Josep M; Albaigés, Joan; Solanas, Anna M

    2011-08-01

    A laboratory experiment was conducted to identify key hydrocarbon degraders from a marine oil spill sample (Prestige fuel oil), to ascertain their role in the degradation of different hydrocarbons, and to assess their biodegradation potential for this complex heavy oil. After a 17-month enrichment in weathered fuel, the bacterial community, initially consisting mainly of Methylophaga species, underwent a major selective pressure in favor of obligate hydrocarbonoclastic microorganisms, such as Alcanivorax and Marinobacter spp. and other hydrocarbon-degrading taxa (Thalassospira and Alcaligenes), and showed strong biodegradation potential. This ranged from >99% for all low- and medium-molecular-weight alkanes (C(15)-C(27)) and polycyclic aromatic hydrocarbons (C(0)- to C(2)- naphthalene, anthracene, phenanthrene, dibenzothiophene, and carbazole), to 75-98% for higher molecular-weight alkanes (C(28)-C(40)) and to 55-80% for the C(3) derivatives of tricyclic and tetracyclic polycyclic aromatic hydrocarbons (PAHs) (e.g., C(3)-chrysenes), in 60 days. The numbers of total heterotrophs and of n-alkane-, aliphatic-, and PAH degraders, as well as the structures of these populations, were monitored throughout the biodegradation process. The salinity of the counting medium affects the counts of PAH degraders, while the carbon source (n-hexadecane vs. a mixture of aliphatic hydrocarbons) is a key factor when counting aliphatic degraders. These limitations notwithstanding, some bacterial genera associated with hydrocarbon degradation (mainly belonging to α- and γ-Proteobacteria, including the hydrocarbonoclastic Alcanivorax and Marinobacter) were identified. We conclude that Thalassospira and Roseobacter contribute to the degradation of aliphatic hydrocarbons, whereas Mesorhizobium and Muricauda participate in the degradation of PAHs.

  6. Turning Bad Press into Prestige.

    ERIC Educational Resources Information Center

    Wassom, Julie

    1995-01-01

    Offers guidance to childcare directors on handling public and parent relations during crisis situations (e.g., an outbreak of chicken pox, a child's death, or teacher's dismissal for reasons that cannot be disclosed). Recommends keen observation, risk management, and good planning. Offers suggestions for handling the situation before, during, and…

  7. 7 CFR 1901.505 - Certificates of beneficial ownership in FmHA or its successor agency under Public Law 103-354 loans.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ...) Establishment of special trusts. From time to time FmHA or its successor agency under Public Law 103-354 will... the unpaid amount is at least equal to the face value of the outstanding unmature certificates... an interest in the special trust to the extent of the face value of such certificates. FmHA or its...

  8. 7 CFR Exhibit C to Subpart E of... - FmHA or Its Successor Agency Under Public Law 103-354 Financed Contract

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 7 Agriculture 12 2013-01-01 2013-01-01 false FmHA or Its Successor Agency Under Public Law 103-354 Financed Contract C Exhibit C to Subpart E of Part 1901 Agriculture Regulations of the Department of... Civil Rights Compliance Requirements Pt. 1901, Subpt. E, Exh. C Exhibit C to Subpart E of Part 1901—FmHA...

  9. Pseudomonas diversity in crude-oil-contaminated intertidal sand samples obtained after the Prestige oil spill.

    PubMed

    Mulet, Magdalena; David, Zoyla; Nogales, Balbina; Bosch, Rafael; Lalucat, Jorge; García-Valdés, Elena

    2011-02-01

    The Galicia seashore, in northwestern Spain, was one of the shorelines affected by the Prestige oil spill in November 2002. The diversity of autochthonous Pseudomonas populations present at two beaches (Carnota municipality) was analyzed using culture-independent and culture-dependent methods. The first analysis involved the screening of an rpoD gene library. The second involved the isolation of 94 Pseudomonas strains that were able to grow on selective media by direct plating or after serial enrichments on several carbon sources: biphenyl, gentisate, hexadecane, methylnaphthalene, naphthalene, phenanthrene, salicylate, xylene, and succinate. Eight denitrifying Pseudomonas strains were also isolated by their ability to grow anaerobically with nitrate. The calculated coverage index for Pseudomonas species was 89% when clones and isolates were considered together, and there were 29 phylospecies detected. The most abundant were members of the species P. stutzeri, P. putida, P. anguilliseptica, and P. oleovorans. Thirty-one isolates could not be identified at the species level and were considered representatives of 16 putative novel Pseudomonas species. One isolate was considered representative of a novel P. stutzeri genomovar. Concordant results were obtained when the diversities of the cloned DNA library and the cultured strains were compared. The clone library obtained by the rpoD PCR method was a useful tool for evaluating Pseudomonas communities and also for microdiversity studies of Pseudomonas populations.

  10. Waste area grouping 2 Phase I task data report: Ecological risk assessment and White Oak Creek watershed screening ecological risk assessment

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Efroymson, R.A.; Jackson, B.L.; Jones, D.S.

    1996-05-01

    This report presents an ecological risk assessment for Waste Area Grouping (WAG) 2 based on the data collected in the Phase I remedial investigation (RI). It serves as an update to the WAG 2 screening ecological risk assessment that was performed using historic data. In addition to identifying potential ecological risks in WAG 2 that may require additional data collection, this report serves to determine whether there are ecological risks of sufficient magnitude to require a removal action or some other expedited remedial process. WAG 2 consists of White Oak Creek (WOC) and its tributaries downstream of the Oak Ridgemore » National Laboratory (ORNL) main plant area, White Oak Lake (WOL), the White Oak Creek Embayment of the Clinch River, associated flood plains, and the associated groundwater. The WOC system drains the WOC watershed, an area of approximately 16.8 km{sup 2} that includes ORNL and associated WAGs. The WOC system has been exposed to contaminants released from ORNL and associated operations since 1943 and continues to receive contaminants from adjacent WAGs.« less

  11. Pleistocene Through Oligocene Record of Himalayan Orogeny and Climate. The Iodp Expedition 354 Drilling Transect across the Middle Bengal Fan at 8°N

    NASA Astrophysics Data System (ADS)

    Spiess, V.; France-Lanord, C.; Schwenk, T.; Klaus, A.

    2015-12-01

    IODP Expedition 354 in the Bay of Bengal February-March 2015 drilled a seven site, 320 km-long transect across the Bengal Fan at 8°N. Three deep penetration and additional four shallow holes provided a spatial overview of the primarily turbiditic depositional system, comprising the Bengal deep sea fan. Sediments originate from Himalayan rivers, documenting terrestrial changes of the monsoon evolution and Himalayan erosion and weathering, and are transported through a delta and shelf canyon, supplying turbidity currents loaded with a full spectrum of grain sizes. Mostly following transport channels, sediments deposit on and between levees, while depocenters are laterally shifting over hundreds of kilometers on millennial time scales. Expedition 354 documented these deposits in space and time by identifying, coring and dating numerous stratigraphic marker horizons across the transect, allowing a detailed reconstruction of channel-levee migration, abandonment, reoccupation and overall uniform growth in the late Pleistocene. High resolution records of these growth patterns were acquired in several levee, interlevee and hemipelagic successions. Miocene through Pliocene fan development was studied at three deeper sites, which document and recovered sand rich facies throughout most of the cores acquired by the half-APC coring technology, intercalated by longer periods of hemipelagic deposition and absence of turbiditic input as the results of major depocenter shifts. Recovered sediments have Himalayan mineralogical and geochemical signatures suitable to reconstruct time series of erosion, weathering and changes in source regions as well as impacts on the global carbon cycle. Miocene shifts in terrestrial vegetation, in sediment budget and in style of sediment transport have been tracked. Expedition 354 has extended the record of early fan deposition by 10 Ma into the Late Oligocene.

  12. 7 CFR 1955.11 - Conveyance of property to FmHA or its successor agency under Public Law 103-354 by trustee in...

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 7 Agriculture 14 2011-01-01 2011-01-01 false Conveyance of property to FmHA or its successor... Real and Chattel Property § 1955.11 Conveyance of property to FmHA or its successor agency under Public... substantial recovery on the FmHA or its successor agency under Public Law 103-354 debt; and (3) FmHA or its...

  13. 7 CFR 1955.11 - Conveyance of property to FmHA or its successor agency under Public Law 103-354 by trustee in...

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 7 Agriculture 14 2010-01-01 2009-01-01 true Conveyance of property to FmHA or its successor agency... Real and Chattel Property § 1955.11 Conveyance of property to FmHA or its successor agency under Public... substantial recovery on the FmHA or its successor agency under Public Law 103-354 debt; and (3) FmHA or its...

  14. Monitoring follow up of two areas affected by the Prestige oil four years after the spillage.

    PubMed

    Fernández-Tajes, Juan; Rábade, Tamara; Laffon, Blanca; Méndez, Josefina

    2011-01-01

    The sinking of the oil tanker Prestige in November 2002 resulted in the spill of more than 63,000 tonnes of crude oil, and polluted more than 1,000 km of coastline, especially affecting Galicia (northwestern Spain). Four years after the accident, a new biological monitoring study was undertaken of two Galician areas intensely affected by the spill, Lira and Ancoradoiro, previously evaluated in the months following the accident ( Laffon et al. 2006 ). The mussel Mytilus galloprovincialis was employed as bioindicator organism to determine both polycyclic aromatic hydrocarbons (PAH) levels and genotoxic effects. PAH were determined chromatographically in seawater samples and mussel tissues collected from November 2006 to January 2008. The results obtained showed that PAH pollution was still present in these areas, but bioaccumulation of these compounds in mussels was low, compared to reference mussels, and lower than in our previous study. DNA damage assessment was also performed in gills and hemolymph cells by means of the alkaline comet assay. DNA damage levels were higher in mussels from the exposed areas than in reference mussels. DNA damage decreased after a 7-d recovery period in the laboratory, but prolonging the recovery period up to 14 d did not contribute to less DNA damage in gill cells. Hemolymph cells were more sensitive than gill cells to the induction of DNA damage.

  15. Field sampling and analysis plan for the remedial investigation of Waste Area Grouping 2 at Oak Ridge National Laboratory, Oak Ridge, Tennessee. Environmental Restoration Program

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Boston, H.L.; Ashwood, T.L.; Borders, D.M.

    1992-02-01

    This field sampling and analysis (S & A) plan has been developed as part of the Department of Energy`s (DOE`s) remedial investigation (RI) of Waste Area Grouping (WAG) 2 at Oak Ridge National Laboratory (ORNL) located in Oak Ridge, Tennessee. The S & A plan has been written in support of the remedial investigation (RI) plan for WAG 2 (ORNL 1990). WAG 2 consists of White Oak Creek (WOC) and its tributaries downstream of the ORNL main plant area, White Oak Lake (WOL), White Oak Creek embayment (WOCE) on the Clinch River, and the associated floodplain and subsurface environment (Fig.more » 1.1). The WOC system is the surface drainage for the major ORNL WAGs and has been exposed to a diversity of contaminants from operations and waste disposal activities in the WOC watershed. WAG 2 acts as a conduit through which hydrologic fluxes carry contaminants from upgradient areas to the Clinch River. Water, sediment, soil, and biota in WAG 2 are contaminated and continue to receive contaminants from upgradient WAGs. This document describes the following: an overview of the RI plan, background information for the WAG 2 system, and objectives of the S & A plan; the scope and implementation of the first 2 years of effort of the S & A plan and includes recent information about contaminants of concern, organization of S & A activities, interactions with other programs, and quality assurance specific to the S & A activities; provides details of the field sampling plans for sediment, surface water, groundwater, and biota, respectively; and describes the sample tracking and records management plan.« less

  16. [G894T (NOS3) and G1958A (MTHFD1) gene polymorphisms and risk of ischemic heart disease in Yucatan, Mexico].

    PubMed

    García-González, Igrid; Solís-Cárdenas, Alberto de Jesús; Flores-Ocampo, Jorge A; Alejos-Mex, Ricardo; Herrera-Sánchez, Luis Fernando; González-Herrera, Lizbeth Josefina

    2015-01-01

    Cardiovascular medicine is focused on the search for genetic risk markers with predictive and/or prognostic value. Among the genetic variants of interest are G894T endothelial nitric oxide synthase and G1958A methylenetetrahydrofolate dehydrogenase1 gene polymorphisms. The aim of this study was to determine the possible association between these polymorphisms and ischemic heart disease in patients from Southern of Mexico (Yucatán). Case-control study matched by age, sex and origin was designed. We studied 98 patients with coronary disease and 101 controls. Participants were evaluated for the usual risk factors. The polymorphisms were identified using the polymerase chain reaction/restriction fragment length polymorphism analysis. Informed consent was obtained from all participants. The G894T and G1958A polymorphisms were not associated with ischemic heart disease, however, the TT genotype (G894T) was associated with the angina (OR=10.2; 95%CI, 1.51-68.8; p=0.025). The genotype GT (G894T) was the most frequent in patients with family history of coronary artery disease. Multiple logistic regression analysis identified smoking (OR=5.21; 95%CI, 2.1-12.9; p=0.000), hypertension (OR=3.54; 95%CI, 1.47-8.56; p=0.005) and obesity (OR=1.16; 95%CI, 1.1-1.27; p=0.001) as risk factors predicting the ischemic heart disease. The G894T and G1958A polymorphisms showed not association with ischemic heart disease. However, homozygosis for the 894T allele (NOS3) confers at risk to develop angina on Yucatán. Copyright © 2014 Sociedad Española de Arteriosclerosis. Published by Elsevier España. All rights reserved.

  17. Work-Anxiety and Sickness Absence After a Short Inpatient Cognitive Behavioral Group Intervention in Comparison to a Recreational Group Meeting.

    PubMed

    Muschalla, Beate; Linden, Michael; Jöbges, Michael

    2016-04-01

    The aim of this study was to study the effects of a short-term cognitive behavior therapy on work-anxiety and sickness-absence in patients with work-anxiety. Three-hundred forty-five inpatients who suffered from cardiologic, neurological, or orthopedic problems and additionally work-anxiety were randomly assigned into two different group interventions. Patients got four sessions of a group intervention, which either focused on cognitive behavior-therapy anxiety-management (work-anxiety coping group, WAG) or unspecific recreational activities (RG). No differences were found between WAG and RG for work-anxiety and subjective work ability. When looking at patients who were suffering only from work-anxiety, and no additional mental disorder, the duration of sickness absence until 6 months follow-up was shorter in the WAG (WAG: 11 weeks, RG: 16 weeks, P = 0.050). A short-term WAG may help return to work in patients with work-anxieties, as long as there is no comorbid mental disorder.

  18. IODP Expedition 354 to the Bengal Fan: a Neogene record of Himalayan erosion. Implications on the carbon cycle

    NASA Astrophysics Data System (ADS)

    France-Lanord, Christian; Spiess, Volkard; Galy, Albert; Galy, Valier; Huyghe, Pascale; Klaus, Adam; IODP Expedition 354 Scientists

    2016-04-01

    Bengal Fan Expedition 354 drilled an E-W transect in the middle fan at 8°N to investigate interactions between the growth of the Himalaya, the development of the Indian monsoon, and processes affecting the carbon cycle. A comprehensive record of turbiditic deposition between the Late Oligocene and Holocene was drilled over a seven sites E-W transect at 8°N. Shipboard results reveal that the chemical and mineralogical compositions of turbiditic sediments cored across the transect are relatively stable throughout the Neogene. By comparison to modern river sediment compositions (Lupker et al. ref), they reveal a weak intensity of chemical weathering without marked variation through time. Clay assemblages are dominated by illite and chlorite with minor proportions of newly formed clays. This differs from the distal fan record (Leg 116) where the Late Miocene and Pliocene turbidites show high weathering signatures and smectite rich clay assemblage. This difference im plies that the distal fan record does not reflect to an evolution of the source erosion. Rather it is controlled by a change in sediment transport within the fan. Shipboard estimates of organic carbon loading and behaviour resemble observations made in the modern Ganga-Brahmaputra river sediments, suggesting efficient terrestrial organic carbon burial in the Bengal Fan [1]. Preliminary observations support the idea that Himalayan erosion has consumed atmospheric CO2 through the burial of organic carbon, more than by silicate weathering. The main evolution observed in Expedition 354 record is the content of detrital carbonate that is persistent through the Neogene but appears to show a consistent decreasing trend from 8-10% during the Miocene to 3-6% during the Pleistocene and Pliocene. Also, a prominent feature of Miocene silt and sand beds is the higher abundance of plant fragments compared to younger sediments. Together these observations reveal changes in the sediment sources and erosion conditions of

  19. Efficiency and protective effect of encapsulation of milk immunoglobulin G in multiple emulsion.

    PubMed

    Chen, C C; Tu, Y Y; Chang, H M

    1999-02-01

    Milk immunoglobulin G (IgG), separated with protein G affinity chromatography, and IgG in colostral whey were encapsulated by 0.5% (w/v) of Tween 80, sucrose stearate, or soy protein, which were used as secondary emulsifiers in the water in oil in water type multiple emulsion. The residual contents of separated IgG and IgG in colostral whey, ranging from 58.7 to 49.7% and from 13.2 to 21.3%, respectively, in the inner water phase (water phase surrounded by oil phase) with emulsifiers were determined by ELISA. However, the emulsion stability decreased after 24 h, and the residual IgG content in the inner water phase was lowered. Encapsulation of IgG in the multiple emulsion increased the stability of separated IgG against acid (pH 2.0) and alkali (pH 12.0) by 21-56% and 33-62%, respectively, depending on the emulsifier used. Moreover, multiple emulsion also provided a remarkable protective effect on separated IgG stability against proteases. The residual contents of separated IgG in multiple emulsion, using Tween 80 as secondary emulsifier, incubated for 2 h with pepsin (pH 2.0) and trypsin and chymotrypsin (pH 7.6) (enzyme/substrate = 1/20) were 35.4, 72.5, and 82.3%, whereas those of separated IgG in enzyme solution were only 7.2, 33. 1, and 35.2%, respectively. However, the separated IgG loss during the preparation of multiple emulsion was almost 41-50%.

  20. von Willebrand's disease antigen II. A new plasma and platelet antigen deficient in severe von Willebrand's disease.

    PubMed Central

    Montgomery, R R; Zimmerman, T S

    1978-01-01

    Factor VIII-related antigen (VIIIag) is deficient in plasma and platelets of patients with severe von Willebrand's disease. This study reports a second von Willebrand's disease antigen (vWagII), distinct from VIIIag, that is also deficient in the platelets and plasma of patients with severe von Willebrand's disease. VIIIag and vWagII are separable by molecular exclusion chromatography, sucrose density gradient ultracentrifugation, and crossed immunoelectrophoresis. They show reactions of immunologic nonidentity with each other, and thus, do not share a precursor-product relationship. vWagII is released from normal platelets during blood clotting, accounting for a fourfold higher concentration of vWagII in serum over plasma. Images PMID:307007

  1. Pseudomonas aestusnigri sp. nov., isolated from crude oil-contaminated intertidal sand samples after the Prestige oil spill.

    PubMed

    Sánchez, David; Mulet, Magdalena; Rodríguez, Ana C; David, Zoyla; Lalucat, Jorge; García-Valdés, Elena

    2014-03-01

    Strains VGXO14(T) and Vi1 were isolated from the Atlantic intertidal shore from Galicia, Spain, after the Prestige oil spill. Both strains were Gram-negative rod-shaped bacteria with one polar inserted flagellum, strictly aerobic, and able to grow at 18-37°C, pH 6-10 and 2-10% NaCl. A preliminary analysis of the 16S rRNA and the partial rpoD gene sequences indicated that these strains belonged to the Pseudomonas genus but were distinct from any known Pseudomonas species. A polyphasic taxonomic approach including phylogenetic, chemotaxonomic, phenotypic and genotypic data confirmed that the strains belonged to the Pseudomonas pertucinogena group. In a multilocus sequence analysis, the similarity of VGXO14(T) and Vi1 to the closest type strain of the group, Pseudomonas pachastrellae, was 90.4%, which was lower than the threshold of 97% established to discriminate species in the Pseudomonas genus. The DNA-DNA hybridisation similarity between strains VGXO14(T) and Vi1 was 79.6%, but below 70% with the type strains in the P. pertucinogena group. Therefore, the strains should be classified within the genus Pseudomonas as a novel species, for which the name Pseudomonas aestusnigri is proposed. The type strain is VGXO14(T) (=CCUG 64165(T)=CECT 8317(T)). Copyright © 2013 Elsevier GmbH. All rights reserved.

  2. Surface debris inventory at White Wing Scrap Yard, Oak Ridge Reservation, Oak Ridge, Tennessee. Environmental Restoration Program

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Rodriguez, R.E.; Tiner, P.F.; Williams, J.K.

    1992-08-01

    An inventory of surface debris in designated grid blocks at the White Wing Scrap Yard [Waste Area Grouping 11 (WAG 11)] was conducted intermittently from February through June 1992 by members of the Measurement Applications and Development Group, Health and Safety Research Division, Oak Ridge National Laboratory (ORNL) at the request of ORNL Environmental Restoration (ER) Program personnel. The objectives of this project are outlined in the following four phases: (1) estimate the amount (volume) and type (e.g., glass, metal and plastics) of surface waste material in 30 designated grid blocks (100- by 100-ft grids); (2) conduct limited air samplingmore » for organic chemical pollutants at selected locations (e.g., near drums, in holes, or other potentially contaminated areas); (3) conduct a walkover gamma radiation scan extending outward (approximately 50 ft) beyond the proposed location of the WAG 11 perimeter fence; and (4) recommend one grid block as a waste staging area. This recommendation is based on location and accessibility for debris staging/transport activities and on low levels of gamma radiation in the grid block.« less

  3. Surface debris inventory at White Wing Scrap Yard, Oak Ridge Reservation, Oak Ridge, Tennessee

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Rodriguez, R.E.; Tiner, P.F.; Williams, J.K.

    1992-08-01

    An inventory of surface debris in designated grid blocks at the White Wing Scrap Yard [Waste Area Grouping 11 (WAG 11)] was conducted intermittently from February through June 1992 by members of the Measurement Applications and Development Group, Health and Safety Research Division, Oak Ridge National Laboratory (ORNL) at the request of ORNL Environmental Restoration (ER) Program personnel. The objectives of this project are outlined in the following four phases: (1) estimate the amount (volume) and type (e.g., glass, metal and plastics) of surface waste material in 30 designated grid blocks (100- by 100-ft grids); (2) conduct limited air samplingmore » for organic chemical pollutants at selected locations (e.g., near drums, in holes, or other potentially contaminated areas); (3) conduct a walkover gamma radiation scan extending outward (approximately 50 ft) beyond the proposed location of the WAG 11 perimeter fence; and (4) recommend one grid block as a waste staging area. This recommendation is based on location and accessibility for debris staging/transport activities and on low levels of gamma radiation in the grid block.« less

  4. Variability in biochemical components of the mussel (Mytilus galloprovincialis) cultured after Prestige oil spill.

    PubMed

    Peteiro, Laura G; Labarta, Uxío; Fernández-Reiriz, María José

    2007-05-01

    The biochemical composition (proteins, carbohydrates, glycogen, total lipids and lipid classes) of the mussel Mytilus galloprovincialis was investigated during an experimental culture using mussel seed from areas with different degree of exposure to the Prestige oil spill. The aim of the study was to identify alterations in the biochemical composition of mussel seed from natural populations commonly used in Galicia for mussel raft culture that might be linked to previous oil exposure. We have selected three mussel seed populations from Pindo, Miranda and Redes, that were characterised in a previous study according to the oil exposure three months after the spill. These populations were transplanted to a raft culture system in the Ría de Ares-Betanzos where our experimental culture followed standard commercial techniques from March 2003 to February 2004. Mussels from Pindo (characterised as the most affected area by the oil spill) showed marked differences in lipid composition with regard to other populations in the content of triacylglycerols, (P<0.001), free fatty acids (P<0.001) and phospholipids (P<0.05) at the onset of the culture. Although these differences in lipid composition might reflect their previous exposition to hydrocarbons, this pattern did not last longer most likely due to depuration of hydrocarbons stored in the tissues or by the development of certain tolerance to PAHs. These significant differences were not detected between Miranda (designed as hardly affected area) and Redes (designed as reference area) which may reflect that Miranda mussels were not affected or only hardly affected by the spill. With the exception of the onset of the culture, biochemical composition showed similar patterns in all mussel populations. Then, the fact of being cultured in a common environment seemed to be more responsible for the long-term variability in the energetic reserve than the origin of the populations or their previous biochemical status.

  5. CO 2 water-alternating-gas injection for enhanced oil recovery: Optimal well controls and half-cycle lengths

    DOE PAGES

    Chen, Bailian; Reynolds, Albert C.

    2018-03-11

    We report that CO 2 water-alternating-gas (WAG) injection is an enhanced oil recovery method designed to improve sweep efficiency during CO 2 injection with the injected water to control the mobility of CO 2 and to stabilize the gas front. Optimization of CO 2 -WAG injection is widely regarded as a viable technique for controlling the CO 2 and oil miscible process. Poor recovery from CO 2 -WAG injection can be caused by inappropriately designed WAG parameters. In previous study (Chen and Reynolds, 2016), we proposed an algorithm to optimize the well controls which maximize the life-cycle net-present-value (NPV). However,more » the effect of injection half-cycle lengths for each injector on oil recovery or NPV has not been well investigated. In this paper, an optimization framework based on augmented Lagrangian method and the newly developed stochastic-simplex-approximate-gradient (StoSAG) algorithm is proposed to explore the possibility of simultaneous optimization of the WAG half-cycle lengths together with the well controls. Finally, the proposed framework is demonstrated with three reservoir examples.« less

  6. Surface water sampling and analysis plan for environmental monitoring in Waste Area Grouping 6 at Oak Ridge National Laboratory, Oak Ridge, Tennessee. Environmental Restoration Program

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Not Available

    1994-06-01

    This Sampling and Analysis Plan addresses surface water monitoring, sampling, and analysis activities that will be conducted in support of the Environmental Monitoring Plan for Waste Area Grouping (WAG) 6. WAG 6 is a shallow-burial land disposal facility for low-level radioactive waste at the Oak Ridge National Laboratory, a research facility owned by the US Department of Energy and managed by Martin Marietta Energy Systems, Inc. Surface water monitoring will be conducted at nine sites within WAG 6. Activities to be conducted will include the installation, inspection, and maintenance of automatic flow-monitoring and sampling equipment and manual collection of variousmore » water and sediment samples. The samples will be analyzed for various organic, inorganic, and radiological parameters. The information derived from the surface water monitoring, sampling, and analysis will aid in evaluating risk associated with contaminants migrating off-WAG, and will be used in calculations to establish relationships between contaminant concentration (C) and flow (Q). The C-Q relationship will be used in calculating the cumulative risk associated with the off-WAG migration of contaminants.« less

  7. CO 2 water-alternating-gas injection for enhanced oil recovery: Optimal well controls and half-cycle lengths

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Chen, Bailian; Reynolds, Albert C.

    We report that CO 2 water-alternating-gas (WAG) injection is an enhanced oil recovery method designed to improve sweep efficiency during CO 2 injection with the injected water to control the mobility of CO 2 and to stabilize the gas front. Optimization of CO 2 -WAG injection is widely regarded as a viable technique for controlling the CO 2 and oil miscible process. Poor recovery from CO 2 -WAG injection can be caused by inappropriately designed WAG parameters. In previous study (Chen and Reynolds, 2016), we proposed an algorithm to optimize the well controls which maximize the life-cycle net-present-value (NPV). However,more » the effect of injection half-cycle lengths for each injector on oil recovery or NPV has not been well investigated. In this paper, an optimization framework based on augmented Lagrangian method and the newly developed stochastic-simplex-approximate-gradient (StoSAG) algorithm is proposed to explore the possibility of simultaneous optimization of the WAG half-cycle lengths together with the well controls. Finally, the proposed framework is demonstrated with three reservoir examples.« less

  8. Multimodal intraoperative neuromonitoring in corrective surgery for adolescent idiopathic scoliosis: Evaluation of 354 consecutive cases

    PubMed Central

    Kundnani, Vishal K; Zhu, Lisa; Tak, HH; Wong, HK

    2010-01-01

    Background: Multimodal intraoperative neuromonitoring is recommended during corrective spinal surgery, and has been widely used in surgery for spinal deformity with successful outcomes. Despite successful outcomes of corrective surgery due to increased safety of the patients with the usage of spinal cord monitoring in many large spine centers, this modality has not yet achieved widespread popularity. We report the analysis of prospectively collected intraoperative neurophysiological monitoring data of 354 consecutive patients undergoing corrective surgery for adolescent idiopathic scoliosis (AIS) to establish the efficacy of multimodal neuromonitoring and to evaluate comparative sensitivity and specificity. Materials and Methods: The study group consisted of 354 (female = 309; male = 45) patients undergoing spinal deformity corrective surgery between 2004 and 2008. Patients were monitored using electrophysiological methods including somatosensory-evoked potentials and motor-evoked potentials simultaneously. Results: Mean age of patients was 13.6 years (±2.3 years). The operative procedures involved were instrumented fusion of the thoracic/lumbar/both curves, Baseline somatosensory-evoked potentials (SSEP) and neurogenic motor-evoked potentials (NMEP) were recorded successfully in all cases. Thirteen cases expressed significant alert to prompt reversal of intervention. All these 13 cases with significant alert had detectable NMEP alerts, whereas significant SSEP alert was detected in 8 cases. Two patients awoke with new neurological deficit (0.56%) and had significant intraoperative SSEP + NMEP alerts. There were no false positives with SSEP (high specificity) but 5 patients with false negatives with SSEP (38%) reduced its sensitivity. There was no false negative with NMEP but 2 of 13 cases were false positive with NMEP (15%). The specificity of SSEP (100%) is higher than NMEP (96%); however, the sensitivity of NMEP (100%) is far better than SSEP (51%). Due to

  9. Analysis of medical student's book reports on Cronin's The Citadel: would young doctors give up ideals for prestige and wealth?

    PubMed

    Hwang, Se Won; Kim, Hun; Kim, Ae Yang; Hwang, Kun

    2016-06-01

    The purpose of this study is to find what medical students think the reward for their future work should be and whether they would keep their ideals or abandon them for prestige and wealth by analyzing the book reports of Cronin's The Citadel. Participants were 50 medical students of junior class. A month before the classroom lecture, the book and digital video disk were provided. Students had discussions in groups of seven and wrote book reports which include answers of three questions. Regarding what should be the reward for the medical doctor, two-thirds of students (66.7%) answered with spiritual compensation, while one-third (33.3%) chose material reward. In the situation presented to Manson, three-fifths (60.0%) answered they would keep their ideals (idealist), while the remaining two-fifths (40.0%) decided they would abandon them. Less than one-third of students (30.0%) answered they would reveal the corruptions of the doctor's society, while two-thirds (64.0%) would not. The larger number of idealists who prefer spiritual reward rather than a material reward represents the innocence of youth as in portrayed in The Citadel.

  10. 7 CFR Exhibit E to Subpart K of... - Guide Letter to Delinquent FmHA or Its Successor Agency Under Public Law 103-354 Single Family...

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 7 Agriculture 13 2013-01-01 2013-01-01 false Guide Letter to Delinquent FmHA or Its Successor Agency Under Public Law 103-354 Single Family Housing Loan Borrowers E Exhibit E to Subpart K of Part..., Subpt. K, Exh. E Exhibit E to Subpart K of Part 1944—Guide Letter to Delinquent FmHA or Its Successor...

  11. 7 CFR Exhibit E to Subpart K of... - Guide Letter to Delinquent FmHA or Its Successor Agency Under Public Law 103-354 Single Family...

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 7 Agriculture 13 2012-01-01 2012-01-01 false Guide Letter to Delinquent FmHA or Its Successor Agency Under Public Law 103-354 Single Family Housing Loan Borrowers E Exhibit E to Subpart K of Part..., Subpt. K, Exh. E Exhibit E to Subpart K of Part 1944—Guide Letter to Delinquent FmHA or Its Successor...

  12. 7 CFR Exhibit E to Subpart K of... - Guide Letter to Delinquent FmHA or Its Successor Agency Under Public Law 103-354 Single Family...

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 7 Agriculture 13 2014-01-01 2013-01-01 true Guide Letter to Delinquent FmHA or Its Successor Agency Under Public Law 103-354 Single Family Housing Loan Borrowers E Exhibit E to Subpart K of Part..., Subpt. K, Exh. E Exhibit E to Subpart K of Part 1944—Guide Letter to Delinquent FmHA or Its Successor...

  13. Pseudomonas gallaeciensis sp. nov., isolated from crude-oil-contaminated intertidal sand samples after the Prestige oil spill.

    PubMed

    Mulet, Magdalena; Sánchez, David; Rodríguez, Ana C; Nogales, Balbina; Bosch, Rafael; Busquets, Antonio; Gomila, Margarita; Lalucat, Jorge; García-Valdés, Elena

    2018-04-11

    Strains V113 T , V92 and V120 have been isolated from sand samples taken at the Atlantic intertidal shore in Galicia, Spain, after the Prestige oil spill. A preliminary analysis of the 16S rRNA and the partial rpoD gene sequences indicated that these strains belonged to the Pseudomonas genus, but they were distinct from any known Pseudomonas species. They were extensively characterized by a polyphasic taxonomic approach and phylogenetic data that confirmed that these strains belonged to the Pseudomonas pertucinogena group. Phylogenetic analysis of 16S rRNA, gyrB and rpoD gene sequences showed that the three strains were 99% similar and were closely related to members of the P. pertucinogena group, with less than 94% similarity to strains of established species; Pseudomonas pachastrellae was the closest relative. The Average Nucleotide Index based on blast values was 89.0% between V113 T and the P. pachastrellae type strain, below the accepted species level (95%). The predominant cellular fatty acid contents and whole cell protein profiles determined by MALDI-TOF mass spectrometry also differentiated the studied strains from known Pseudomonas species. We therefore conclude that strains V113 T , V92 and V120 represent a novel species of Pseudomonas, for which the name Pseudomonas gallaeciensis is proposed; the type strain is V113 T (=CCUG 67583 T =LMG 29038 T ). Copyright © 2018 Elsevier GmbH. All rights reserved.

  14. The infiltration of experimentally induced lung metastases of colon carcinoma CC531 by adoptively transferred interleukin-2-activated natural killer cells in Wag rats.

    PubMed

    Kuppen, P J; Basse, P H; Goldfarb, R H; Van De Velde, C J; Fleuren, G J; Eggermont, A M

    1994-02-15

    The number of IL-2-activated natural killer (A-NK) cells reaching the tumor site in vivo may be crucial for their anti-tumor effect following adoptive immunotherapy. We investigated in a syngeneic rat model the infiltration of established lung metastases by adoptively transferred A-NK cells. The Wag rat colon carcinoma CC531 was injected via a tail vein to induce pulmonary metastases. Syngeneic A-NK cells were labeled with the fluorescent dye rhodamine (TRITC) and next injected via a tail vein in rats bearing day-12 lung tumors. The number of A-NK cells in tumor and in normal tissue per rat was counted in sections after administration of A-NK cells. At all time points tested, a significant linear relationship between the cross-section area of the tumor and the number of infiltrating cells was observed, but small tumor areas became fully infiltrated earlier than larger areas. At 24 hr after injection, approximately 10% of the injected cells were found in the tumor tissue and the average A-NK-cell-to-tumor-cell ratio was estimated to be 1:3. A-NK cells were found in the liver too, although the number of cells per mm2 tissue was low compared with the pulmonary tumor tissue. Very low numbers of A-NK cells were found in kidney, adrenal gland, spleen, and blood. We conclude that, in this syngeneic rat model, adoptively transferred A-NK cells are able to find and specifically infiltrate pulmonary metastases in a time-dependent fashion.

  15. Cervical disc arthroplasty with the Prestige LP disc versus anterior cervical discectomy and fusion, at 2 levels: results of a prospective, multicenter randomized controlled clinical trial at 24 months.

    PubMed

    Gornet, Matthew F; Lanman, Todd H; Burkus, J Kenneth; Hodges, Scott D; McConnell, Jeffrey R; Dryer, Randall F; Copay, Anne G; Nian, Hui; Harrell, Frank E

    2017-06-01

    OBJECTIVE The authors compared the efficacy and safety of arthroplasty using the Prestige LP cervical disc with those of anterior cervical discectomy and fusion (ACDF) for the treatment of degenerative disc disease (DDD) at 2 adjacent levels. METHODS Patients from 30 investigational sites were randomized to 1 of 2 groups: investigational patients (209) underwent arthroplasty using a Prestige LP artificial disc, and control patients (188) underwent ACDF with a cortical ring allograft and anterior cervical plate. Patients were evaluated preoperatively, intraoperatively, and at 1.5, 3, 6, 12, and 24 months postoperatively. Efficacy and safety outcomes were measured according to the Neck Disability Index (NDI), Numeric Rating Scales for neck and arm pain, 36-Item Short-Form Health Survey (SF-36), gait abnormality, disc height, range of motion (investigational) or fusion (control), adverse events (AEs), additional surgeries, and neurological status. Treatment was considered an overall success when all 4 of the following criteria were met: 1) NDI score improvement of ≥ 15 points over the preoperative score, 2) maintenance or improvement in neurological status compared with preoperatively, 3) no serious AE caused by the implant or by the implant and surgical procedure, and 4) no additional surgery (supplemental fixation, revision, or nonelective implant removal). Independent statisticians performed Bayesian statistical analyses. RESULTS The 24-month rates of overall success were 81.4% for the investigational group and 69.4% for the control group. The posterior mean for overall success in the investigational group exceeded that in the control group by 0.112 (95% highest posterior density interval = 0.023 to 0.201) with a posterior probability of 1 for noninferiority and 0.993 for superiority, demonstrating the superiority of the investigational group for overall success. Noninferiority of the investigational group was demonstrated for all individual components of overall

  16. Characterization of Co(III) EDTA-Reducing Bacteria in Metal- and Radionuclide-Contaminated Groundwater

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Gao, Weimin; Gentry, Terry J; Mehlhorn, Tonia L

    The Waste Area Grouping 5 (WAG5) site at Oak Ridge National Laboratory has a potential to be a field site for evaluating the effectiveness of various bioremediation approaches and strategies. The site has been well studied in terms of its geological and geochemical properties over the past decade. However, despite the importance of microorganisms in bioremediation processes, the microbiological populations at the WAG5 site and their potential in bioremediation have not been similarly evaluated. In this study, we initiated research to characterize the microbial populations in WAG5 groundwater. Approximately 100 isolates from WAG5 groundwater were isolated and selected based onmore » colony morphology. Fifty-five unique isolates were identified by BOX-PCR and subjected to further characterization. 16S rRNA sequences indicated that these isolates belong to seventeen bacterial genera including Alcaligenes (1 isolate), Aquamonas (1), Aquaspirillum (1), Bacillus (10), Brevundimonas (5), Caulobacter (7), Dechloromonas (2), Janibacter (1), Janthinobacterium (2), Lactobacillus (1), Paenibacillus (4), Pseudomonas (9), Rhodoferax (1), Sphingomonas (1), Stenotrophomonas (6), Variovorax (2), and Zoogloea (1). Metal respiration assays identified several isolates, which phylogenically belong or are close to Caulobacter, Stenotrophomonas, Bacillus, Paenibacillus and Pseudomonas, capable of reducing Co(III)EDTA- to Co(II)EDTA{sup 2-} using the defined M1 medium under anaerobic conditions. In addition, using WAG5 groundwater directly as the inoculants, we found that organisms associated with WAG5 groundwater can reduce both Fe(III) and Co(III) under anaerobic conditions. Further assays were then performed to determine the optimal conditions for Co(III) reduction. These assays indicated that addition of various electron donors including ethanol, lactate, methanol, pyruvate, and acetate resulted in metal reduction. These experiments will provide useful background information for

  17. Ecological monitoring of intertidal phytobenthic communities of the Basque Coast (N. Spain) following the Prestige oil spill.

    PubMed

    Díez, I; Secilla, A; Santolaria, A; Gorostiaga, J M

    2009-12-01

    Following the Prestige oil spill, six-monthly samplings (spring and autumn) of intertidal macroalgal assemblages were carried out from 2004 to 2006 in twelve locations along the Basque coast. Macroalgal species appeared to be little modified, but species richness, diversity, and algal cover were significantly lower in the first year of the study, so it cannot be ruled out that the arrival of oil on the Basque coast might have had a damaging effect on intertidal communities. On the other hand, no significant differences were detected between locations slightly and moderately affected by oil in any of the structural parameters considered. By contrast, significant differences were detected between locations within each oiling level that indicate that other natural environmental factors play a greater role in the differences between locations than the oiling level. Likewise, significant differences were detected between areas within each location which were not consistent with time, indicating that communities are highly heterogeneous in species richness, diversity and algal cover at the scale of tens of meters. The dominant Corallina elongata and most of the accompanying species did not show significant year-on-year differences in terms of cover. Also, there were no differences between the two oiling levels. Analyses revealed a high spatial variability at the scale of kilometers (locations) and tens of meters (areas) for most of the taxa. The results obtained provide detailed quantitative data on intertidal phytobenthic assemblages of the Basque coast at different spatial and temporal scales that were hitherto unavailable for the region.

  18. Using RNA-Seq to assemble a rose transcriptome with more than 13,000 full-length expressed genes and to develop the WagRhSNP 68k Axiom SNP array for rose (Rosa L.).

    PubMed

    Koning-Boucoiran, Carole F S; Esselink, G Danny; Vukosavljev, Mirjana; van 't Westende, Wendy P C; Gitonga, Virginia W; Krens, Frans A; Voorrips, Roeland E; van de Weg, W Eric; Schulz, Dietmar; Debener, Thomas; Maliepaard, Chris; Arens, Paul; Smulders, Marinus J M

    2015-01-01

    In order to develop a versatile and large SNP array for rose, we set out to mine ESTs from diverse sets of rose germplasm. For this RNA-Seq libraries containing about 700 million reads were generated from tetraploid cut and garden roses using Illumina paired-end sequencing, and from diploid Rosa multiflora using 454 sequencing. Separate de novo assemblies were performed in order to identify single nucleotide polymorphisms (SNPs) within and between rose varieties. SNPs among tetraploid roses were selected for constructing a genotyping array that can be employed for genetic mapping and marker-trait association discovery in breeding programs based on tetraploid germplasm, both from cut roses and from garden roses. In total 68,893 SNPs were included on the WagRhSNP Axiom array. Next, an orthology-guided assembly was performed for the construction of a non-redundant rose transcriptome database. A total of 21,740 transcripts had significant hits with orthologous genes in the strawberry (Fragaria vesca L.) genome. Of these 13,390 appeared to contain the full-length coding regions. This newly established transcriptome resource adds considerably to the currently available sequence resources for the Rosaceae family in general and the genus Rosa in particular.

  19. Analysis of medical student’s book reports on Cronin’s The Citadel: would young doctors give up ideals for prestige and wealth?

    PubMed Central

    2016-01-01

    Purpose: The purpose of this study is to find what medical students think the reward for their future work should be and whether they would keep their ideals or abandon them for prestige and wealth by analyzing the book reports of Cronin’s The Citadel. Methods: Participants were 50 medical students of junior class. A month before the classroom lecture, the book and digital video disk were provided. Students had discussions in groups of seven and wrote book reports which include answers of three questions. Results: Regarding what should be the reward for the medical doctor, two-thirds of students (66.7%) answered with spiritual compensation, while one-third (33.3%) chose material reward. In the situation presented to Manson, three-fifths (60.0%) answered they would keep their ideals (idealist), while the remaining two-fifths (40.0%) decided they would abandon them. Less than one-third of students (30.0%) answered they would reveal the corruptions of the doctor’s society, while two-thirds (64.0%) would not. Conclusion: The larger number of idealists who prefer spiritual reward rather than a material reward represents the innocence of youth as in portrayed in The Citadel. PMID:27240894

  20. Initial cytotoxicity assays of media for sulfate-reducing bacteria: An endodontic biopharmaceutical product under development.

    PubMed

    Heggendorn, Fabiano Luiz; Silva, Gabriela Cristina de Carvalho; Cardoso, Elisama Azevedo; Castro, Helena Carla; Gonçalves, Lúcio Souza; Dias, Eliane Pedra; Lione, Viviane de Oliveira Freitas; Lutterbach, Márcia Teresa Soares

    2016-01-01

    This study assessed the cell viability of the inoculation vehicle of BACCOR (a combination of sulfate-reducing bacteria plus a culture media for bacteria), a biopharmaceutical product under development for dental use as aid in fractured endodontic file removal from the root canal. Different culture media for bacteria were evaluated: modified Postgate E (MCP-E mod), Modified Postgate E without Agar-agar (MCP-E w/Ag), Postgate C with Agar-agar (MCP-C Ag) and Postgate C without Agar-agar (MCP-C w/Ag). Cytotoxicity was quantified by the MTT test, exposing L929 and Vero cell lines to the vehicles over 24 h. The exposure of L929 cell line to MCP-E w/Ag resulted in biocompatibility (52% cell viability), while the exposure of the Vero kidney line revealed only MCP-E mod as cytotoxic. When diluted, all the vehicles showed biocompatibility with both cell lines. MCP-E w/Ag was the vehicle chosen for BACCOR, because of its biocompatibility with the cells used.

  1. (Z)-3,5,4'-Trimethoxystilbene Limits Hepatitis C and Cancer Pathophysiology by Blocking Microtubule Dynamics and Cell Cycle Progression

    PubMed Central

    Nguyen, Charles B.; Kotturi, Hari; Waris, Gulam; Mohammed, Altaf; Chandrakesan, Parthasarathy; May, Randal; Sureban, Sripathi; Weygant, Nathaniel; Qu, Dongfeng; Rao, Chinthalapally V.; Dhanasekaran, Danny N.; Bronze, Michael S.; Houchen, Courtney W.; Ali, Naushad

    2016-01-01

    Hepatocellular carcinoma (HCC) is the third most common cause of cancer-related deaths worldwide. Chronic hepatitis C virus (HCV) infection causes induction of several tumor/cancer stem cell (CSC) markers and is known to be a major risk factor for development of HCC. Therefore, drugs that simultaneously target viral replication and CSC properties are needed for a risk-free treatment of advanced stage liver diseases including HCC. Here, we demonstrated that (Z)-3,5,4’-trimethoxystilbene (Z-TMS) exhibits potent anti-tumor and anti-HCV activities without exhibiting cytotoxicity to human hepatocytes in vitro or in mice livers. Diethylnitrosamine (DEN)/carbon tetrachloride (CCl4) extensively induced expression of DCLK1 (a CSC marker) in the livers of C57BL/6 mice following hepatic injury. Z-TMS exhibited hepatoprotective effects against DEN/CCl4-induced injury by reducing DCLK1 expression and improving histological outcomes. The drug caused bundling of DCLK1 with microtubules and blocked cell cycle progression at G2/M phase in hepatoma cells via downregulation of CDK1, induction of p21cip1/waf1 expression, and inhibition of Akt (Ser473) phosphorylation. Z-TMS also inhibited proliferation of erlotinib-resistant lung adenocarcinoma cells (H1975) bearing the T790M EGFR mutation most likely by promoting autophagy and nuclear fragmentation. In conclusion, Z-TMS appears to be a unique therapeutic agent targeting HCV and concurrently eliminating cells with neoplastic potential during chronic liver diseases including HCC. It may also be a valuable drug for targeting drug-resistant carcinomas and cancers of the lungs, pancreas, colon, and intestine in which DCLK1 is involved in tumorigenesis. PMID:27287718

  2. Mechanically Stacked Dual-Junction and Triple-Junction III-V/Si-IBC Cells with Efficiencies Exceeding 31.5% and 35.4%: Preprint

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Schnabel, Manuel; Tamboli, Adele C; Warren, Emily L

    Despite steady advancements in the efficiency of crystalline Silicon (c-Si) photovoltaics (PV) within the last decades, the theoretical efficiency limit of 29.4 percent depicts an insurmountable barrier for silicon-based single-junction solar cells. Combining the Si cell with a second absorber material on top in a dual junction tandem or triple junction solar cell is an attractive option to surpass this limit significantly. We demonstrate a mechanically stacked GaInP/Si dual-junction cell with an in-house measured efficiency of 31.5 percent and a GaInP/GaAs/Si triple-junction cell with a certified efficiency of 35.4 percent.

  3. The Prestige oil spill: a laboratory study about the toxicity of the water-soluble fraction of the fuel oil.

    PubMed

    Navas, José M; Babín, Mar; Casado, Susana; Fernández, Carlos; Tarazona, José V

    2006-07-01

    The Prestige oil spill caused severe effects on the coastal fauna and flora due to direct contact of organisms with the fuel oil. However, the water soluble fraction (WSF) of the fuel oil can also provoke deleterious effects in the long term and even in regions not directly affected by the spill. Our objective was to determine the toxicity of the WSF using a battery of laboratory toxicity tests. To obtain a WSF in the laboratory, a sample of the spilled fuel was mixed with adequate medium, sonicated, agitated and filtered. No cytotoxic effects were detected in RTG-2 cells exposed to the WSF. In an algae growth inhibition test (OECD test guideline 201) the WSF did not affect the growth of Chlorella vulgaris. Furthermore, acute and reproductive toxicity tests (OECD test guideline 202) carried out using Daphnia magna did not indicate any deleterious effect of the WSF. In a bioassay designed in our laboratory, D. magna were fed with algae previously exposed to the fuel, but no toxic effects were detected. However, the WSF was able to induce a dose-dependent increase of ethoxyresorufin-O-deethylase activity in RTG-2 cells, indicating the presence of chemicals that could cause sub-lethal effects to organisms. After chemical analyses it was established that the final total quantity of polyaromatic hydrocarbons dissolved in medium was approximately 70 ng/ml. These low concentrations explain the observed lack of toxicity.

  4. Antidepressants but not antipsychotics have antiepileptogenic effects with limited effects on comorbid depressive-like behaviour in the WAG/Rij rat model of absence epilepsy

    PubMed Central

    Citraro, Rita; Leo, Antonio; De Fazio, Pasquale; De Sarro, Giovambattista; Russo, Emilio

    2015-01-01

    Background and Purpose Two of the most relevant unmet needs in epilepsy are represented by the development of disease-modifying drugs able to affect epileptogenesis and/or the study of related neuropsychiatric comorbidities. No systematic study has investigated the effects of chronic treatment with antipsychotics or antidepressants on epileptogenesis. However, such drugs are known to influence seizure threshold. Experimental Approach We evaluated the effects of an early long-term treatment (ELTT; 17 weeks), started before seizure onset (P45), with fluoxetine (selective 5-HT-reuptake inhibitor), duloxetine (dual-acting 5-HT-noradrenaline reuptake inhibitor), haloperidol (typical antipsychotic drug), risperidone and quetiapine (atypical antipsychotic drugs) on the development of absence seizures and comorbid depressive-like behaviour in the WAG/Rij rat model. Furthermore, we studied the effects of these drugs on established absence seizures in adult (6-month-old) rats after a chronic 7 weeks treatment. Key Results ELTT with all antipsychotics did not affect the development of seizures, whereas, both ELTT haloperidol (1 mg·kg−1 day−1) and risperidone (0.5 mg·kg−1 day−1) increased immobility time in the forced swimming test and increased absence seizures only in adult rats (7 weeks treatment). In contrast, both fluoxetine (30 mg·kg−1 day−1) and duloxetine (10–30 mg·kg−1 day−1) exhibited clear antiepileptogenic effects. Duloxetine decreased and fluoxetine increased absence seizures in adult rats. Duloxetine did not affect immobility time; fluoxetine 30 mg·kg−1 day−1 reduced immobility time while at 10 mg·kg−1 day−1 an increase was observed. Conclusions and Implications In this animal model, antipsychotics had no antiepileptogenic effects and might worsen depressive-like comorbidity, while antidepressants have potential antiepileptogenic effects even though they have limited effects on comorbid depressive-like behaviour. PMID

  5. Cilioretinal artery: Vasculogenesis might be promoted by plasminogen activator inhibitor-1 5G allele.

    PubMed

    Yilmaz, Sarenur; Ardagil, Aylin; Akalin, Ibrahim; Altinel, Meltem Guzin; Dag, Yasar; Kurum, Esra; Koyun, Efe; Ari Yaylali, Sevil; Bayramlar, Huseyin

    2017-01-01

    Cilioretinal arteries (CAs) represent enlargements of microscopic and early established collaterals formed via vasculogenesis between choroidal and retinal circulations. We aimed to investigate whether genetic tendency to thrombosis due to well-known gene polymorphisms may induce CA vasculogenesis in embryonic life. We assessed plasminogen activator inhibitor-1 (PAI-1) 4G/5G, methylenetetrahydrofolatereductase (MTHFR), FACTOR V LEIDEN and PROTHROMBIN gene polymorphisms on 130 patients [82/48 females/males; Median age: 57 (18-84) with visible CAs and 100 (64/36: female/male; Median age: 55 (19-90)] without visible CAs. Using multiple logistic regression models, we found PAI-1 4G/5G; MTHFR (C677T and A1298C) polymorphisms to have significant effects on the probability of visible CAs, that having at least one 5G allele would increase the odds of having visible cilioretinal artery by 98.4% [Odds ratio: 1984 (95% CI: 1.320-3.000, p = 0.001)], and having at least one MTHFR C677T or A1298C allele would decrease the odds of having visible CAs by approximately 38% (OR = 0.618, 95% CI: 0.394-0.961, p = 0.035) or 44% (OR = 0.558, 95% CI: 0.354-0.871, p = 0.011), respectively. This is the first study to test the existence of significant association between presence of enlarged and visible CAs and genetic factors predisposing to thrombosis, according to the literature. Here we suggest that not only the lack of genetic predisposition to thrombosis by MTHFR gene polymorphisms, but also the PAI-1 5G allele might promote vasculogenesis of CAs.

  6. Not Surprised, But Concerned: The Professoriate's Reaction to PETE Doctoral Education in the United States

    ERIC Educational Resources Information Center

    Parker, Melissa; Sutherland, Sue; Sinclair, Christina; Ward, Phillip

    2011-01-01

    The purpose of this qualitative study was to initiate a discussion and explore reactions to PETE doctoral education in the United States. A purposeful sample of 27 representatives from doctoral and non doctoral granting programs in the U.S. was interviewed. Analysis resulted in four themes: (a) Is the dog wagging its tail or the tail wagging the…

  7. Alterations in hippocampal and cortical densities of functionally different interneurons in rat models of absence epilepsy.

    PubMed

    Papp, Péter; Kovács, Zsolt; Szocsics, Péter; Juhász, Gábor; Maglóczky, Zsófia

    2018-05-31

    Recent data from absence epileptic patients and animal models provide evidence for significant impairments of attention, memory, and psychosocial functioning. Here, we outline aspects of the electrophysiological and structural background of these dysfunctions by investigating changes in hippocampal and cortical GABAergic inhibitory interneurons in two genetically absence epileptic rat strains: the Genetic Absence Epilepsy Rats from Strasbourg (GAERS) and the Wistar Albino Glaxo/Rijswijk (WAG/Rij) rats. Using simultaneously recorded field potentials from the primary somatosensory cortex (S1 cortex, seizure focus) and the hippocampal hilus, we demonstrated that typical frequencies of spike-wave discharges (SWDs; 7-8 Hz, GAERS; 7-9 Hz, WAG/Rij) and their harmonics appeared and their EEG spectral power markedly increased on recordings not only from the S1 cortex, but also from the hilus in both GAERS and WAG/Rij rats during SWDs. Moreover, we observed an increased synchronization between S1 cortex and hilus at 7-8 Hz (GAERS) and 7-9 Hz (WAG/Rij) and at their harmonics when SWDs occurred in the S1 cortex in both rat strains. In addition, using immunohistochemistry we demonstrated changes in the densities of perisomatic (parvalbumin-immunopositive, PV+) and interneuron-selective (calretinin-immunopositive, CR+) GABAergic inhibitory interneuron somata. Specifically, GAERS and WAG/Rij rats displayed lower densities of PV-immunopositivity in the hippocampal hilus compared to non-epileptic control (NEC) and normal Wistar rats. GAERS and WAG/Rij rats also show a marked reduction in the density of CR + interneurons in the same region in comparison with NEC rats. Data from the S1 cortex reveals bidirectional differences in PV + density, with GAERS displaying a significant increase, whereas WAG/Rij a reduction compared to control rat strains. Our results suggest an enhanced synchronization and functional connections between the hippocampus and S1 cortex as well

  8. The role of G-CSF in recurrent implantation failure: A randomized double blind placebo control trial.

    PubMed

    Davari-Tanha, Fatemeh; Shahrokh Tehraninejad, Ensieh; Ghazi, Mohadese; Shahraki, Zahra

    2016-12-01

    Recurrent implantation failure (RIF) is the absence of implantation after three consecutive In Vitro Fertilization (IVF) cycles with transferring at least four good quality embryos in a minimum of three fresh or frozen cycles in a woman under 40 years. The definition and management of RIF is under constant scrutiny. To investigate the effects of Granulocyte colony stimulating factor (G-CSF) on RIF, pregnancy rate, abortion rate and implantation rates. A double blind placebo controlled randomized trial was conducted at two tertiary university based hospitals. One hundred patients with the history of RIF from December 2011 until January 2014 were recruited in the study. G-CSF 300µg/1ml was administered at the day of oocyte puncture or day of progesterone administration of FET cycle. Forty patients were recruited at G-CSF group, 40 in saline and 20 in placebo group. The mean age for whole study group was 35.3±4.2 yrs (G-CSF 35.5±4.32, saline 35.3±3.98, placebo 35.4±4.01, respectively). Seventeen patients had a positive pregnancy test after embryo transfer [10 (25%) in G-CSF; 5 (12.5%) in saline; and 2 (10%) in placebo group]. The mean of abortion rates was 17.6% (3), two of them in G-CSF, one in saline group. The implantation rate was 12.3% in G-CSF, 6.1% in saline and 4.7% in placebo group. G-CSF may increase chemical pregnancy and implantation rate in patients with recurrent implantation failure but clinical pregnancy rate and abortion rate was unaffected.

  9. Using Polymer Alternating Gas to Enhance Oil Recovery in Heavy Oil

    NASA Astrophysics Data System (ADS)

    Yang, Yongzhi; Li, Weirong; Zhou, Tiyao; Dong, Zhenzhen

    2018-02-01

    CO2 has been used to recover oil for more than 40 years. Currently, about 43% of EOR production in U.S. is from CO2 flooding. CO2 flooding is a well-established EOR technique, but its density and viscosity nature are challenges for CO2 projects. Low density (0.5 to 0.8 g/cm3) causes gas to rise upward in reservoirs and bypass many lower portions of the reservoir. Low viscosity (0.02 to 0.08 cp) leads to poor volumetric sweep efficiency. So water-alternating-gas (WAG) method was used to control the mobility of CO2 and improve sweep efficiency. However, WAG process has some other problems in heavy oil reservoir, such as poor mobility ratio and gravity overriding. To examine the applicability of carbon dioxide to recover viscous oil from highly heterogeneous reservoirs, this study suggests a new EOR method--polymer-alternating gas (PAG) process. The process involves a combination of polymer flooding and CO2 injection. To confirm the effectiveness of PAG process in heavy oils, a reservoir model from Liaohe Oilfield is used to compare the technical and economic performance among PAG, WAG and polymer flooding. Simulation results show that PAG method would increase oil recovery over 10% compared with other EOR methods and PAG would be economically success based on assumption in this study. This study is the first to apply PAG to enhance oil recovery in heavy oil reservoir with highly heterogeneous. Besides, this paper provides detailed discussions and comparison about PAG with other EOR methods in this heavy oil reservoir.

  10. Structural and vibrational study of a neurotransmitter molecule: Dopamine [4-(2-aminoethyl) benzene-1,2-diol

    NASA Astrophysics Data System (ADS)

    Jha, Omkant; Yadav, T. K.; Yadav, R. A.

    2018-01-01

    Structural and vibrational studies for the most stable conformer of dopamine {4-(2-Aminoethyl) benzene-1, 2-diol} have been carried out at the DFT/B3LYP/6-311 ++G** level using the Gaussian 09 software. The IR and Raman spectra have been recorded and analyzed in light of the computed vibrational parameters using the DFT and the PEDs computed with the help of the GAR2PED software. Some of the fundamentals have considerably changed frequencies in going from benzene to dopamine. Except the rocking and wagging modes of the NH2 group the other four modes are pure group modes. The rocking and wagging modes of the NH2 group show mixing with the other modes. The two Osbnd H stretching vibrations are highly localized modes. The Kekule phenyl ring stretching mode is found to remain almost unchanged. The HOMO-LUMO study suggests the existence of charge transfer within the molecule and the energy gap supports the pharmacological active property of the dopamine molecule. The NBO analysis has been carried out to understand the proper and improper hydrogen bonding.

  11. Multi-epoch monitoring of the AA Tauri-like star V 354 Mon. Indications for a low gas-to-dust ratio in the inner disk warp

    NASA Astrophysics Data System (ADS)

    Schneider, P. C.; Manara, C. F.; Facchini, S.; Günther, H. M.; Herczeg, G. J.; Fedele, D.; Teixeira, P. S.

    2018-06-01

    Disk warps around classical T Tauri stars (CTTSs) can periodically obscure the central star for some viewing geometries. For these so- called AA Tau-like variables, the obscuring material is located in the inner disk and absorption spectroscopy allows one to characterize its dust and gas content. Since the observed emission from CTTSs consists of several components (photospheric, accretion, jet, and disk emission), which can all vary with time, it is generally challenging to disentangling disk features from emission variability. Multi- epoch, flux-calibrated, broadband spectra provide us with the necessary information to cleanly separate absorption from emission variability. We applied this method to three epochs of VLT/X-shooter spectra of the CTTS V 354 Mon (CSI Mon-660) located in NGC 2264 and find that: (a) the accretion emission remains virtually unchanged between the three epochs; (b) the broadband flux evolution is best described by disk material obscuring part of the star, and (c) the Na and K gas absorption lines show only a minor increase in equivalent width during phases of high dust extinction. The limits on the absorbing gas column densities indicate a low gas-to-dust ratio in the inner disk, less than a tenth of the ISM value. We speculate that the evolutionary state of V 354 Mon, rather old with a low accretion rate, is responsible for the dust excess through an evolution toward a dust dominated disk or through the fragmentation of larger bodies that drifted inward from larger radii in a still gas dominated disk.

  12. Marine ecosystem health status assessment through integrative biomarker indices: a comparative study after the Prestige oil spill "Mussel Watch".

    PubMed

    Marigómez, Ionan; Garmendia, Larraitz; Soto, Manu; Orbea, Amaia; Izagirre, Urtzi; Cajaraville, Miren P

    2013-04-01

    Five integrative biomarker indices are compared: Bioeffects Assessment Index (BAI), Health Status Index (HSI), integrated biological response (IBR), ecosystem health condition chart (EHCC) and Integrative Biomarker Index (IBI). They were calculated on the basis of selected biomarker data collected in the framework of the Prestige oil spill (POS) Mussel Watch monitoring (2003-2006) carried out in Galicia and the Bay of Biscay. According to the BAI, the health status of mussels was severely affected by POS and signals of recovery were evidenced in Galicia after April-04 and in Biscay Bay after April-05. The HSI (computed by an expert system) revealed high levels of environmental stress in 2003 and a recovery trend from April-04 to April-05. In July-05, the health status of mussels worsened but in October-05 and April-06 healthy condition was again recorded in almost all localities. IBR/n and IBI indicated that mussel health was severely affected in 2003 and improved from 2004 onwards. EHCC reflected a deleterious environmental condition in 2003 and a recovery trend after April-04, although a healthy ecosystem condition was not achieved in April-06 yet. Whereas BAI and HSI provide a basic indication of the ecosystem health status, star plots accompanying IBR/n and IBI provide complementary information concerning the mechanisms of biological response to environmental insult. Overall, although the integrative indices based on biomarkers show different sensitivity, resolution and informative output, all of them provide coherent information, useful to simplify the interpretation of biological effects of pollution in marine pollution monitoring. Each others' advantages, disadvantages and applicability for ecosystem health assessment are discussed.

  13. 30 CFR 206.354 - How do I determine generating deductions?

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ...) Depreciation under paragraphs (g) and (h) of this section and a return on undepreciated capital investment under paragraphs (g) and (i) of this section; or (iv) A return on capital investment in the power plant... allowable expenses. (g) To compute costs associated with capital investment, a lessee may use either...

  14. Viscous and gravitational fingering in multiphase compositional and compressible flow

    NASA Astrophysics Data System (ADS)

    Moortgat, Joachim

    2016-03-01

    Viscous and gravitational fingering refer to flow instabilities in porous media that are triggered by adverse mobility or density ratios, respectively. These instabilities have been studied extensively in the past for (1) single-phase flow (e.g., contaminant transport in groundwater, first-contact-miscible displacement of oil by gas in hydrocarbon production), and (2) multi-phase immiscible and incompressible flow (e.g., water-alternating-gas (WAG) injection in oil reservoirs). Fingering in multiphase compositional and compressible flow has received much less attention, perhaps due to its high computational complexity. However, many important subsurface processes involve multiple phases that exchange species. Examples are carbon sequestration in saline aquifers and enhanced oil recovery (EOR) by gas or WAG injection below the minimum miscibility pressure. In multiphase flow, relative permeabilities affect the mobility contrast for a given viscosity ratio. Phase behavior can also change local fluid properties, which can either enhance or mitigate viscous and gravitational instabilities. This work presents a detailed study of fingering behavior in compositional multiphase flow in two and three dimensions and considers the effects of (1) Fickian diffusion, (2) mechanical dispersion, (3) flow rates, (4) domain size and geometry, (5) formation heterogeneities, (6) gravity, and (7) relative permeabilities. Results show that fingering in compositional multiphase flow is profoundly different from miscible conditions and upscaling techniques used for the latter case are unlikely to be generalizable to the former.

  15. PINOID AGC kinases are necessary for phytochrome-mediated enhancement of hypocotyl phototropism in Arabidopsis.

    PubMed

    Haga, Ken; Hayashi, Ken-ichiro; Sakai, Tatsuya

    2014-11-01

    Several members of the AGCVIII kinase subfamily, which includes PINOID (PID), PID2, and WAVY ROOT GROWTH (WAG) proteins, have previously been shown to phosphorylate PIN-FORMED (PIN) auxin transporters and control the auxin flow in plants. PID has been proposed as a key component of the phototropin signaling pathway that induces phototropic responses, although the responses were not significantly impaired in the pid single and pid wag1 wag2 triple mutants. This raises questions about the functional roles of the PID family in phototropic responses. Here, we investigated hypocotyl phototropism in the pid pid2 wag1 wag2 quadruple mutant in detail to clarify the roles of the PID family in Arabidopsis (Arabidopsis thaliana). The pid quadruple mutants exhibited moderate responses in continuous light-induced phototropism with a decrease in growth rates of hypocotyls and normal responses in pulse-induced phototropism. However, they showed serious defects in enhancements of pulse-induced phototropic curvatures and lateral fluorescent auxin transport by red light pretreatment. Red light pretreatment significantly reduced the expression level of PID, and the constitutive expression of PID prevented pulse-induced phototropism, irrespective of red light pretreatment. This suggests that the PID family plays a significant role in phytochrome-mediated phototropic enhancement but not the phototropin signaling pathway. Red light treatment enhanced the intracellular accumulation of PIN proteins in response to the vesicle-trafficking inhibitor brefeldin A in addition to increasing their expression levels. Taken together, these results suggest that red light preirradiation enhances phototropic curvatures by up-regulation of PIN proteins, which are not being phosphorylated by the PID family. © 2014 American Society of Plant Biologists. All Rights Reserved.

  16. PINOID AGC Kinases Are Necessary for Phytochrome-Mediated Enhancement of Hypocotyl Phototropism in Arabidopsis1[W][OPEN

    PubMed Central

    Haga, Ken; Hayashi, Ken-ichiro; Sakai, Tatsuya

    2014-01-01

    Several members of the AGCVIII kinase subfamily, which includes PINOID (PID), PID2, and WAVY ROOT GROWTH (WAG) proteins, have previously been shown to phosphorylate PIN-FORMED (PIN) auxin transporters and control the auxin flow in plants. PID has been proposed as a key component of the phototropin signaling pathway that induces phototropic responses, although the responses were not significantly impaired in the pid single and pid wag1 wag2 triple mutants. This raises questions about the functional roles of the PID family in phototropic responses. Here, we investigated hypocotyl phototropism in the pid pid2 wag1 wag2 quadruple mutant in detail to clarify the roles of the PID family in Arabidopsis (Arabidopsis thaliana). The pid quadruple mutants exhibited moderate responses in continuous light-induced phototropism with a decrease in growth rates of hypocotyls and normal responses in pulse-induced phototropism. However, they showed serious defects in enhancements of pulse-induced phototropic curvatures and lateral fluorescent auxin transport by red light pretreatment. Red light pretreatment significantly reduced the expression level of PID, and the constitutive expression of PID prevented pulse-induced phototropism, irrespective of red light pretreatment. This suggests that the PID family plays a significant role in phytochrome-mediated phototropic enhancement but not the phototropin signaling pathway. Red light treatment enhanced the intracellular accumulation of PIN proteins in response to the vesicle-trafficking inhibitor brefeldin A in addition to increasing their expression levels. Taken together, these results suggest that red light preirradiation enhances phototropic curvatures by up-regulation of PIN proteins, which are not being phosphorylated by the PID family. PMID:25281709

  17. RCRA Facility investigation report for Waste Area Grouping 6 at Oak Ridge National Laboratory, Oak Ridge, Tennessee. Volume 5, Technical Memorandums 06-09A, 06-10A, and 06-12A

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    None

    This report provides a detailed summary of the activities carried out to sample groundwater at Waste Area Grouping (WAG) 6. The analytical results for samples collected during Phase 1, Activity 2 of the WAG 6 Resource Conservation and Recovery Act Facility Investigation (RFI) are also presented. In addition, analytical results for Phase 1, activity sampling events for which data were not previously reported are included in this TM. A summary of the groundwater sampling activities of WAG 6, to date, are given in the Introduction. The Methodology section describes the sampling procedures and analytical parameters. Six attachments are included. Attachmentsmore » 1 and 2 provide analytical results for selected RFI groundwater samples and ORNL sampling event. Attachment 3 provides a summary of the contaminants detected in each well sampled for all sampling events conducted at WAG 6. Bechtel National Inc. (BNI)/IT Corporation Contract Laboratory (IT) RFI analytical methods and detection limits are given in Attachment 4. Attachment 5 provides the Oak Ridge National Laboratory (ORNL)/Analytical Chemistry Division (ACD) analytical methods and detection limits and Resource Conservation and Recovery Act (RCRA) quarterly compliance monitoring (1988--1989). Attachment 6 provides ORNL/ACD groundwater analytical methods and detection limits (for the 1990 RCRA semi-annual compliance monitoring).« less

  18. Biosimilar G-CSF versus filgrastim and lenograstim in healthy unrelated volunteer hematopoietic stem cell donors.

    PubMed

    Farhan, Roiya; Urbanowska, Elżbieta; Zborowska, Hanna; Król, Małgorzata; Król, Maria; Torosian, Tigran; Piotrowska, Iwona; Bogusz, Krzysztof; Skwierawska, Kamila; Wiktor-Jędrzejczak, Wiesław; Snarski, Emilian

    2017-10-01

    The World Marrow Donor Organization recommends original granulocyte-colony stimulating factor (G-CSF) for the mobilization of stem cells in healthy unrelated hematopoietic stem cell donors. We report the comparison of a biosimilar G-CSF (Zarzio) with two original G-CSFs (filgrastim and lenograstim) in mobilization in unrelated donors. We included data of 313 consecutive donors who were mobilized during the period from October 2014 to March 2016 at the Medical University of Warsaw. The primary endpoints of this study were the efficiency of CD34+ cell mobilization to the circulation and results of the first apheresis. The mean daily dose of G-CSF was 9.1 μg/kg for lenograstim, 9.8 μg/kg for biosimilar filgrastim, and 9.3 μg/kg for filgrastim (p < 0.001). The mean CD34+ cell number per microliter in the blood before the first apheresis was 111 for lenograstim, 119 for biosimilar filgrastim, and 124 for filgrastim (p = 0.354); the mean difference was even less significant when comparing CD34+ number per dose of G-CSF per kilogram (p = 0.787). Target doses of CD34+ cells were reached with one apheresis in 87% donors mobilized with lenograstim and in 93% donors mobilized with original and biosimilar filgrastim (p = 0.005). The mobilized apheresis outcomes (mean number of CD34+ cells/kg of donor collected during the first apheresis) was similar with lenograstim, biosimilar filgrastim, and filgrastim: 6.2 × 10 6 , 7.6 × 10 6 , and 7.3 × 10 6 , respectively, p = 0.06. There was no mobilization failure in any of the donors. Biosimilar G-CSF is as effective in the mobilization of hematopoietic stem cells in unrelated donors as original G-CSFs. Small and clinically irrelevant differences seen in the study can be attributed to differences in G-CSF dose and collection-related factors. Active safety surveillance concurrent to clinical use and reporting to donor outcome registry (e.g., EBMT donor outcome registry or WMDA SEAR/SPEAR) might help to evaluate

  19. Remedial investigation report on Waste Area Grouping 5 at Oak Ridge National Laboratory, Oak Ridge, Tennessee. Volume 1: Technical summary

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    NONE

    1995-09-01

    A remedial investigation (RI) was performed to support environmental restoration activities for Waste Area Grouping (WAG) 5 at the Oak Ridge National Laboratory (ORNL) in Oak Ridge, Tennessee. The WAG 5 RI made use of the observational approach, which concentrates on collecting only information needed to assess site risks and support future cleanup work. This information was interpreted and is presented using the framework of the site conceptual model, which relates contaminant sources and release mechanisms to migration pathways and exposure points that are keyed to current and future environmental risks for both human and ecological receptors. The site conceptualmore » model forms the basis of the WAG 5 remedial action strategy and remedial action objectives. The RI provided the data necessary to verify this model and allows recommendations to be made to accomplish those objectives.« less

  20. Accumulation trends of petroleum hydrocarbons in commercial shellfish from the Galician coast (NW Spain) affected by the Prestige oil spill.

    PubMed

    Viñas, L; Franco, M A; Soriano, J A; González, J J; Ortiz, L; Bayona, J M; Albaigés, J

    2009-04-01

    Aliphatic and aromatic hydrocarbons were determined in three species of commercial shellfish, namely razor shells (Ensis arcuatus and Ensis siliqua), goose barnacle (Pollicipes cornucopia) and sea urchin (Paracentrotus lividus), living in different habitats and exhibiting different feeding behaviors. The samples were collected monthly, from January 2003 to October 2004, in three stations of the Galicia coast (NW Spain), following the Prestige oil spill, with the aim of assessing their response to the spill and, therefore, their suitability for monitoring purposes. The aliphatic fractions were mostly dominated by biogenic hydrocarbons, reflecting the diet composition of the organisms and their low metabolic capacity. The presence of oil was assessed by the determination of chemical markers. The analysis of the aromatic fractions revealed the occurrence of 3-6 ring parent and alkylated PAHs, consistent with a mixed petrogenic-pyrolytic origin, with the common feature of the predominance of chrysene in all samples collected after the spill. However, the distributions exhibited both temporal and interspecies variations. The PAH concentrations (Sigma13) increased significantly after the spill and decreased 6-7 months later close to background levels for the region. One year after the accident, the median values were: 58 microg/kg for razor shells, 26 microg/kg for barnacles, and 25 microg/kg for sea urchins. The temporal evolution of the PAH concentrations along the survey period was used to estimate loss rates for bioavailable PAHs in barnacles and sea urchins after the spill. Half-life values were in the order of 30 and 60 d, respectively. The results of the study demonstrate that barnacles can be suitable species for oil spill monitoring.

  1. RCRA Facility Investigation report for Waste Area Grouping 6 at Oak Ridge National Laboratory, Oak Ridge, Tennessee. Volume 2. Sections 4 through 9

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    None

    1991-09-01

    This report presents compiled information concerning a facility investigation of waste area group 6(WAG-6), of the solid waste management units (SWMU's) at Oak Ridge National Laboratory (ORNL). The WAG is a shallow ground disposal area for low-level radioactive wastes and chemical wastes. The report contains information on hydrogeological data, contaminant characterization, radionuclide concentrations, risk assessment and baseline human health evaluation including a toxicity assessment, and a baseline environmental evaluation.

  2. Clinical trial: a novel high-dose 1 g mesalamine suppository (Salofalk) once daily is as efficacious as a 500-mg suppository thrice daily in active ulcerative proctitis.

    PubMed

    Andus, Tilo; Kocjan, Andreas; Müser, Moritz; Baranovsky, Andrey; Mikhailova, Tatyana L; Zvyagintseva, Tatyana D; Dorofeyev, Andrey E; Lozynskyy, Yurii S; Cascorbi, Ingolf; Stolte, Manfred; Vieth, Michael; Dilger, Karin; Mohrbacher, Ralf; Greinwald, Roland

    2010-11-01

    Mesalamine suppositories are first-line therapy in active ulcerative proctitis; the standard regime still recommends multiple doses per day. The primary objective of this study was to show the noninferiority of once-daily administration of a novel 1 g mesalamine suppository versus thrice-daily administration of the 0.5 g mesalamine suppository. This was a single-blind (investigator-blinded), randomized, multicenter, comparative, Phase III clinical trial. Patients with mild to moderately active ulcerative proctitis inserted either one mesalamine 1 g suppository at bedtime or one mesalamine 0.5 g suppository thrice daily over a 6-week period. The primary endpoint was rate of remission (Disease Activity Index below 4). In all, 354 patients were evaluable for safety and per-protocol analysis. The new regimen demonstrated noninferiority: The percentage of patients with remission was 87.9% for the once-daily 1 g mesalamine suppository and 90.7% for the thrice-daily 0.5 g mesalamine suppository. Each regimen resulted in prompt cessation of clinical symptoms (e.g., median time to ≤3 stools per day (all without blood): 5 days in the 1 g mesalamine once-daily and 7 days in the 0.5 g mesalamine thrice-daily group). Patients preferred applying suppositories once a day. In active ulcerative proctitis the once-daily administration of a 1 g mesalamine suppository is as effective and safe, yet considerably more convenient, than the standard thrice-daily administration of a 0.5 g mesalamine suppository.

  3. Structural and vibrational study of a neurotransmitter molecule: Dopamine [4-(2-aminoethyl) benzene-1,2-diol].

    PubMed

    Jha, Omkant; Yadav, T K; Yadav, R A

    2018-01-15

    Structural and vibrational studies for the most stable conformer of dopamine {4-(2-Aminoethyl) benzene-1, 2-diol} have been carried out at the DFT/B3LYP/6-311++G** level using the Gaussian 09 software. The IR and Raman spectra have been recorded and analyzed in light of the computed vibrational parameters using the DFT and the PEDs computed with the help of the GAR2PED software. Some of the fundamentals have considerably changed frequencies in going from benzene to dopamine. Except the rocking and wagging modes of the NH 2 group the other four modes are pure group modes. The rocking and wagging modes of the NH 2 group show mixing with the other modes. The two OH stretching vibrations are highly localized modes. The Kekule phenyl ring stretching mode is found to remain almost unchanged. The HOMO-LUMO study suggests the existence of charge transfer within the molecule and the energy gap supports the pharmacological active property of the dopamine molecule. The NBO analysis has been carried out to understand the proper and improper hydrogen bonding. Copyright © 2017. Published by Elsevier B.V.

  4. RCRA Facility Investigation report for Waste Area Grouping 6 at Oak Ridge National Laboratory, Oak Ridge, Tennessee. Volume 3. Appendixes 1 through 8

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    None

    1991-09-01

    This report presents compiled information concerning a facility investigation of waste area group 6(WAG-6), of the solid waste management units (SWMU'S) at Oak Ridge National Laboratory (ORNL). The WAG is a shallow ground disposal area for low-level radioactive wastes and chemical wastes. The report contains information on hydrogeological data, contaminant characterization, radionuclide concentrations, risk assessment from doses to humans and animals and associated cancer risks, exposure via food chains, and historical data. (CBS)

  5. The U.S. Gas Flooding Experience: CO2 Injection Strategies and Impact on Ultimate Recovery

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Nunez-Lopez, Vanessa; Hosseini, Seyyed; Gil-Egui, Ramon

    The Permian Basin in West Texas and southwestern New Mexico has seen 45 years of oil reserve growth through CO2 enhanced oil recovery (CO2 EOR). More than 60 CO2 EOR projects are currently active in the region’s limestone, sandstone and dolomite reservoirs. Water alternating gas (WAG) has been the development strategy of choice in the Permian for several technical and economic reasons. More recently, the technology started to get implemented in the much more porous and permeable clastic depositional systems of the onshore U.S. Gulf Coast. Continued CO2 injection (CGI), as opposed to WAG, was selected as the injection strategymore » to develop Gulf Coast oil fields, where CO2 injection volumes are significantly larger (up to 6 times larger) than those of the Permian. We conducted a compositional simulation based study with the objective of comparing the CO2 utilization ratios (volume of CO2 injected to produce a barrel of oil) of 4 conventional and novel CO2 injection strategies: (1) continuous gas injection (CGI), (2) water alternating gas (WAG), (3) water curtain injection (WCI), and (4) WAG and WCI combination. These injection scenarios were simulated using the GEM module from the Computer Modeling Group (CMG). GEM is an advanced general equation-of-state compositional simulator, which includes equation of state, CO2 miscible flood, CO2/brine interactions, and complex phase behavior. The simulator is set up to model three fluid phases including water, oil, and gas. Our study demonstrates how the selected field development strategy has a significant impact on the ultimate recovery of CO2-EOR projects, with GCI injection providing maximum oil recovery in absolute volume terms, but with WAG offering a more balanced technical-economical approach.« less

  6. Miocene denudation history of Himalaya deduced from IODP Exp. 354 Bengal Fan

    NASA Astrophysics Data System (ADS)

    Kohki, Y.; Cruz, J. W.; Osaki, A.; Manoj, M. C.; Hatano, N.; France-Lanord, C.; Spiess, V.; Klaus, A.

    2017-12-01

    The submarine Bengal Fan is the largest submarine fan on Earth and covers the whole Bay of Bengal. The sediments are fed by the Ganges and Brahmaputra rivers reflecting India-Asia plate collision. The sediments recovered from IODP Expedition 354 Bengal Fan record the uplift history of the Himalayan orogenic system. We examined the chemical composition of detrital garnets in the Miocene deposits from Site U1451, where drilling reached to basal horizon of the fan deposits, in order to reveal the detailed denudation history of Himalayan metamorphic rocks. For this purpose, the comparison of chemical composition between detrital garnet in the Bengal Fan deposits and metamorphic garnet in Himalayan metamorphic rocks was carried out. The chemical composition of the metamorphic garnet from Higher Himalayan Crystalline (HHC) in Karnali and Kaligandaki areas, western Nepal, was examined for chemical reference to detrital garnets in Bengal Fan. The metamorphic garnets in "Formation I (Le Fort, 1975)" in HHC are characterized by almandine-rich garnet with high pyrope content. Also, the garnets in "Formation II" are remarked by two types of garnets, i.e., almandine-rich and grandite-rich garnets. Meanwhile, the composition of garnets in "Formation III" is almandine-rich garnet with low pyrope content. In the Bengal Fan deposits, the characteristic garnets, which show the similarity to the metamorphic garnet in HHC, is not found from the Lower Miocene (Burdigalian) deposits. In the Middle and Upper Miocene deposits, the almandine-rich garnets characteristic in Formation I, are normally included. At the basal part of the Middle Miocene (Langhian), almandine-rich garnets with low pyrope content, suggesting the derivation from Formation III, are remarkable. The grandite-rich garnets from Formation II are sporadically found In the Upper Miocene deposits (Tortonian-Messinian). Above chemical comparison between the detrital garnets in Bengal Fan and metamorphic garnets from HHC

  7. Effect of filter on average glandular dose and image quality in digital mammography

    NASA Astrophysics Data System (ADS)

    Songsaeng, C.; Krisanachinda, A.; Theerakul, K.

    2016-03-01

    To determine the average glandular dose and entrance surface air kerma in both phantoms and patients to assess image quality for different target-filters (W/Rh and W/Ag) in digital mammography system. The compressed breast thickness, compression force, average glandular dose, entrance surface air kerma, peak kilovoltage and tube current time were recorded and compared between W/Rh and W/Ag target filter. The CNR and the figure of merit were used to determine the effect of target filter on image quality. The mean AGD of the W/Rh target filter was 1.75 mGy, the mean ESAK was 6.67 mGy, the mean CBT was 54.1 mm, the mean CF was 14 1bs. The mean AGD of W/Ag target filter was 2.7 mGy, the mean ESAK was 12.6 mGy, the mean CBT was 75.5 mm, the mean CF was 15 1bs. In phantom study, the AGD was 1.2 mGy at 4 cm, 3.3 mGy at 6 cm and 3.83 mGy at 7 cm thickness. The FOM was 24.6, CNR was 9.02 at thickness 6 cm. The FOM was 18.4, CNR was 8.6 at thickness 7 cm. The AGD from Digital Mammogram system with W/Rh of thinner CBT was lower than the AGD from W/Ag target filter.

  8. Health and safety plan for the Remedial Investigation and Site Investigation of Waste Area Grouping 2 at the Oak Ridge National Laboratory, Oak Ridge, Tennessee. Environmental Restoration Program

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Cofer, G.H.; Holt, V.L.; Roupe, G.W.

    1993-11-01

    This health and safety plan (HASP) was developed by the members of the Measurement Applications and Development Group of the Health Science Research Division at the Oak Ridge National Laboratory (ORNL). This plan was prepared to ensure that health and safety related items for the Waste Area Grouping (WAG) 2 Remedial Investigation (RI)/Feasibility Study and Site Investigation projects conform with the requirements of 29 CFR 1910.120 (April 18, 1992). The RI Plan calls for the characterization, monitoring, risk assessment, and identification of remedial needs and alternatives that have been structured and staged with short-term and long-term objectives. In early FYmore » 1992, the WAG 2 RI was integrated with the ORNL Environmental Restoration (ER) Site Investigations program in order to achieve the complimentary objectives of the projects more effectively by providing an integrated basis of support. The combined effort was named the WAG 2 Remedial Investigation and Site Investigations Program (WAG 2 RI&SI). The Site Investigation activities are a series of monitoring efforts and directed investigations that support other ER activities by providing information about (1) watershed hydrogeology; (2) contaminants, pathways, and fluxes for groundwater at ORNL; (3) shallow subsurface areas that can act as secondary sources of contaminants; and (4) biological populations and contaminants in biota, in addition to other support and coordination activities.« less

  9. Somatic alterations of the serine/threonine kinase LKB1 gene in squamous cell (SCC) and large cell (LCC) lung carcinoma.

    PubMed

    Strazisar, Mojca; Mlakar, Vid; Rott, Tomaz; Glavac, Damjan

    2009-05-01

    Somatic LKB1 serine/threonine kinase alterations are rare in sporadic cancers, with the exception lung adenocarcinoma, but no mutations in squamous cell or large cell primary carcinoma were discovered. We screened the LKB1 gene in 129 primary nonsmall cell lung carcinomas, adjacent healthy lung tissue, and control blood samples. Forty-five percent of nonsmall cell lung tumors harbored either intron or exon alterations. We identified R86G, F354L, Y272Y and three polymorphisms: 290+36G/T, 386+156G/T, and 862+145C/T (novel). R86G (novel) and F354L mutations were found in six squamous cell carcinomas and three large cell cancer carcinomas, but not in the adjacent healthy tissue or controls samples. The F354L mutation was found in advanced squamous cell carcinomas with elevated COX-2 expression, rare P53, and no K-RAS mutation. Results indicate that the LKB1 gene is changed in a certain proportion of nonsmall cell lung tumors, predominately in advanced squamous lung carcinoma. Inactivation of the gene takes place via the C-terminal domain and could be related to mechanisms influencing tumor initiation, differentiation, and metastasis.

  10. Introduction.

    PubMed

    Tepikin, Alexei V

    2017-01-01

    In the title of this part of the book, the tail is wagging not just in a single dog but multiple dogs; in other words, a single process SOCE (tail) somehow involves a cross talk of (wagging) large and powerful organelle and cellular compartments (dogs). So how is this possible? Is this really necessary? Is the title actually appropriate?SOCE is a rather special process, it allows efficient signaling based on a ubiquitous second messenger (Ca 2+ ) in multiple cell and tissue types, it has specific signaling modality (i.e., some downstream reactions depend specifically on SOCE and not just on global Ca 2+ increase), it is vital for the normal functioning of multiple types of cells and tissues, and when misregulated it induces important pathological processes. The reader hopefully agree that such an important "tail" is more appropriate for a kangaroo than for a Chihuahua and that it has awesome wagging capacity.

  11. Improvement of Sweep Efficiency in Gasflooding

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Kishore Mohanty

    2008-12-31

    Miscible and near-miscible gasflooding has proven to be one of the few cost effective enhance oil recovery techniques in the past twenty years. As the scope of gas flooding is being expanded to medium viscosity oils in shallow sands in Alaska and shallower reservoirs in the lower 48, there are questions about sweep efficiency in near-miscible regions. The goal of this research is to evaluate sweep efficiency of various gas flooding processes in a laboratory model and develop numerical tools to estimate their effectiveness in the field-scale. Quarter 5-spot experiments were conducted at reservoir pressure to evaluate the sweep efficiencymore » of gas, WAG and foam floods. The quarter 5-spot model was used to model vapor extraction (VAPEX) experiments at the lab scale. A streamline-based compositional simulator and a commercial simulator (GEM) were used to model laboratory scale miscible floods and field-scale pattern floods. An equimolar mixture of NGL and lean gas is multicontact miscible with oil A at 1500 psi; ethane is a multicontact miscible solvent for oil B at pressures higher than 607 psi. WAG improves the microscopic displacement efficiency over continuous gas injection followed by waterflood in corefloods. WAG improves the oil recovery in the quarter 5-spot over the continuous gas injection followed by waterflood. As the WAG ratio increases from 1:2 to 2:1, the sweep efficiency in the 5-spot increases, from 39.6% to 65.9%. A decrease in the solvent amount lowers the oil recovery in WAG floods, but significantly higher amount of oil can be recovered with just 0.1 PV solvent injection over just waterflood. Use of a horizontal production well lowers the oil recovery over the vertical production well during WAG injection phase in this homogeneous 5-spot model. Estimated sweep efficiency decreases from 61.5% to 50.5%. In foam floods, as surfactant to gas slug size ratio increases from 1:10 to 1:1, oil recovery increases. In continuous gasflood VAPEX processes

  12. 7 CFR Exhibit D to Subpart G of... - Implementation Procedures for the Endangered Species Act

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... for the Endangered Species Act 1. FmHA or its successor agency under Public Law 103-354 shall implement the consultation procedures required under Section 7 of the Endangered Species Act as specified in... State Director that a request for an exemption from section 7 of the Endangered Species Act is not...

  13. 7 CFR Exhibit D to Subpart G of... - Implementation Procedures for the Endangered Species Act

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... for the Endangered Species Act 1. FmHA or its successor agency under Public Law 103-354 shall implement the consultation procedures required under Section 7 of the Endangered Species Act as specified in... State Director that a request for an exemption from section 7 of the Endangered Species Act is not...

  14. 7 CFR Exhibit D to Subpart G of... - Implementation Procedures for the Endangered Species Act

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... for the Endangered Species Act 1. FmHA or its successor agency under Public Law 103-354 shall implement the consultation procedures required under Section 7 of the Endangered Species Act as specified in... State Director that a request for an exemption from section 7 of the Endangered Species Act is not...

  15. 7 CFR Exhibit D to Subpart G of... - Implementation Procedures for the Endangered Species Act

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... for the Endangered Species Act 1. FmHA or its successor agency under Public Law 103-354 shall implement the consultation procedures required under Section 7 of the Endangered Species Act as specified in... State Director that a request for an exemption from section 7 of the Endangered Species Act is not...

  16. 7 CFR Exhibit D to Subpart G of... - Implementation Procedures for the Endangered Species Act

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... for the Endangered Species Act 1. FmHA or its successor agency under Public Law 103-354 shall implement the consultation procedures required under Section 7 of the Endangered Species Act as specified in... State Director that a request for an exemption from section 7 of the Endangered Species Act is not...

  17. Trophic ecology of the swimming crab Polybius henslowii Leach, 1820 in Galician and Cantabrian Seas: Influences of natural variability and the Prestige oil spill

    NASA Astrophysics Data System (ADS)

    Signa, G.; Cartes, J. E.; Solé, M.; Serrano, A.; Sánchez, F.

    2008-11-01

    Diet and feeding intensity of the portunid crab Polybius henslowii were studied during the spring of 2004 along Galician and Cantabrian continental shelves (NW Iberian Peninsula) between 78 and 287 m. The area had been affected by the Prestige oil spill in November 2002, with different sectors at different levels of pollution: highest in between Miño River and Cape Finisterre (MF) and from there to Estaca de Bares Point (FE) and lowest from Estaca to Cape Peñas (EP). From 37272 specimens collected in 59 bottom hauls, 342 were analysed for stomach fullness and diet composition. Stomach fullness was lower in FE, but with no significant differences among sectors. Diet was a mixture of pelagic and benthic prey: cephalopods ( Ilex coindetti), brachyurans ( P. henslowii) and polychaetes ( Glycera sp.). Other prey were beloniform eggs and fish remains. Two stress markers were also studied in some specimens: Acetylcholinesterase (a neurotoxicity marker) varied among sampled areas, while lipid peroxidation (an oxidative stress marker) did not. Changes in trophic variables, distribution and density were analysed in relation to depth, surface and bottom T, surface Chl a from satellite imagery and tar aggregate concentration in sediments. Along Galician and Cantabrian coasts prey availability, linked to productivity level, seems to be the main factor affecting P. henslowii diet and distribution. Interannual abundance variability seems to be controlled by large-scale climatic conditions (NAO index). This natural variability masks possible effects induced by the oil spill.

  18. Maternal and Paternal Resources across Childhood and Adolescence as Predictors of Young Adult Achievement.

    PubMed

    Sun, Xiaoran; McHale, Susan M; Updegraff, Kimberly A

    2017-06-01

    Family experiences have been linked to youth's achievements in childhood and adolescence, but we know less about their long term implications for educational and occupational achievements in young adulthood. Grounded in social capital theory and ecological frameworks, this study tested whether mothers' and fathers' education and occupation attainments, as well as the mean level and cross-time consistency of parental warmth during childhood and adolescence, predicted educational and occupational achievements in young adulthood. We also tested interactions between parental achievement and warmth in predicting these young adult outcomes. Data were collected from mothers, fathers, and firstborn and secondborn siblings in 164 families at up to 11 time points. Predictors came from the first nine annual points (youth age M = 10.52 at Time 1) and outcomes from when young adults averaged 26 years old (firstborns at Time 10, secondborns at Time 11). Results from multilevel models revealed that both mothers' and fathers' educational attainment and warmth consistency from childhood through adolescence predicted young adults' educational attainment. Fathers' occupational prestige predicted sons', but not daughters', prestige. An interaction between mothers' warmth consistency, occupational prestige, and youth gender revealed that, for sons whose mothers' prestige was low, warmth consistency positively predicted their prestige, but this association was nonsignificant when mothers' prestige was high. Conversely, for daughters with mothers high in prestige, warmth consistency was a trend level, positive predictor of daughters' prestige, but was nonsignificant when mothers' prestige was low. Thus, maternal resources appeared to have a cumulative impact on daughters, but the process for sons was compensatory. Discussion focuses on the role of family resources in the gender gap in young adult achievement.

  19. Maternal and Paternal Resources across Childhood and Adolescence as Predictors of Young Adult Achievement

    PubMed Central

    Sun, Xiaoran; McHale, Susan M.; Updegraff, Kimberly A.

    2017-01-01

    Family experiences have been linked to youth’s achievements in childhood and adolescence, but we know less about their long term implications for educational and occupational achievements in young adulthood. Grounded in social capital theory and ecological frameworks, this study tested whether mothers’ and fathers’ education and occupation attainments, as well as the mean level and cross-time consistency of parental warmth during childhood and adolescence, predicted educational and occupational achievements in young adulthood. We also tested interactions between parental achievement and warmth in predicting these young adult outcomes. Data were collected from mothers, fathers, and firstborn and secondborn siblings in 164 families at up to 11 time points. Predictors came from the first nine annual points (youth age M = 10.52 at Time 1) and outcomes from when young adults averaged 26 years old (firstborns at Time 10, secondborns at Time 11). Results from multilevel models revealed that both mothers’ and fathers’ educational attainment and warmth consistency from childhood through adolescence predicted young adults’ educational attainment. Fathers’ occupational prestige predicted sons’, but not daughters’, prestige. An interaction between mothers’ warmth consistency, occupational prestige, and youth gender revealed that, for sons whose mothers’ prestige was low, warmth consistency positively predicted their prestige, but this association was nonsignificant when mothers’ prestige was high. Conversely, for daughters with mothers high in prestige, warmth consistency was a trend level, positive predictor of daughters’ prestige, but was nonsignificant when mothers’ prestige was low. Thus, maternal resources appeared to have a cumulative impact on daughters, but the process for sons was compensatory. Discussion focuses on the role of family resources in the gender gap in young adult achievement. PMID:28983122

  20. Evolution of the Middle Bengal Fan at 8°N in the Oligocene to Pliocene - Preliminary Results from IODP Expedition 354

    NASA Astrophysics Data System (ADS)

    Volkhard, Spiess; Tilmann, Schwenk; Fenna, Bergmann; Christian, France-Lanord; Adam, Klaus

    2016-04-01

    Three deep penetration and additional four shallow sites were drilled during IODP Expedition 354 in the Bay of Bengal at 8°N in February-March 2015 across a 320 km-long transect to study Neogene Bengal fan deposition. The three deeper sites located on top of the elevated crustal features of the Ninetyeast Ridge (Site U1451) and 85°Ridge (Site U1455/DSDP Site 218) as well as central between them (Site U1450) shall provide the stratigraphic framework for the Oligocene to Pliocene reconstruction of fan deposition and sedimentary fluxes driven by monsoon evolution and Himalayan erosion and weathering. Based on shipboard biostratigraphy, drilled material reach back in geologic time to the late Miocene (Site U1450), middle Miocene (Site U1455) and Oligocene (Site U1451). While core recovery was generally severely reduced due to the presence of unconsolidated sand and silt units, half-length APC coring technology provided valuable sand samples/recovery down to ~800 meters below seafloor. Increased compaction/diagenesis of units indicating the temporary absence of fan deposition due to major depocenter shifts, comprising of calcarous clay units of mostly pelagic origin, required a change to rotary coring between 600 and 800 mbsf, and thus the presence of sand is mostly uncertain for those deeper sections. However, derived from penetration rates, a high proportion of sand is anticipated back to early Miocene or Oligocene times. The calcareous clay units serve as stratigraphic marker horizons, which turned out to be suitable for seismic correlation across the drilling transect. This in turn allows to determine sedimentary budgets and overall fan growth for numerous time slices. Recovered sediments have Himalayan mineralogical and geochemical signatures suitable to analyze time series of erosion, weathering and changes in source regions as well as impacts on the global carbon cycle. Miocene shifts in terrestrial vegetation, in sediment budget and in style of sediment

  1. 5-HT has contrasting effects in the frontal cortex, but not the hypothalamus, on changes in noradrenaline efflux induced by the monoamine releasing-agent, d-amphetamine, and the reuptake inhibitor, BTS 54 354.

    PubMed

    Géranton, Sandrine M; Heal, David J; Stanford, S Clare

    2004-03-01

    There is extensive evidence for functional interactions between central noradrenergic and serotonergic neurones. Here, dual-probe microdialysis was used in freely-moving rats to compare the effects of 5-HT on noradrenergic transmission in the rat frontal cortex and hypothalamus. We studied the effects of the 5-HT synthesis inhibitor, para-chlorophenylalanine (pCPA; which depleted 5-HT stores in both the frontal cortex and the hypothalamus), on spontaneous efflux of noradrenaline and on the noradrenergic responses to d-amphetamine, and the monoamine reuptake inhibitor, BTS 54 354. pCPA pretreatment alone did not affect spontaneous noradrenaline efflux in either brain region, whether or not alpha2-autoreceptors were inactivated by administration of the alpha2-antagonist, atipamezole (1 mg/kg i.p). However, in the frontal cortex, pCPA pretreatment augmented the amplitude of, and prolonged, the noradrenergic response to local infusion of d-amphetamine (10 microM). In contrast, pCPA abolished the increase in cortical noradrenaline efflux induced by local infusion of BTS 54 354 (50 microM). In the hypothalamus, pCPA did not affect the amplitude of the response to either of these agents but did prolong the effects of d-amphetamine on noradrenaline efflux. These findings suggest that serotonergic transmission has complex effects on the noradrenergic response to drugs that increase noradrenergic transmission in the frontal cortex, but has less influence in the hypothalamus.

  2. Expedition 354 on the Bengal fan: a Neogene record of Himalayan erosion

    NASA Astrophysics Data System (ADS)

    France-Lanord, C.; Spiess, V.; Schwenk, T.; Klaus, A.; Galy, A.

    2017-12-01

    Drilling in the Bengal fan generated a comprehensive record of Himalayan erosion over the Neogene and Quaternary. It documents the interplay between Himalayan tectonic and the monsoon. The fan is predominantly composed of detrital turbiditic sediments originating from Himalayan rivers, and transported through the delta and shelf canyon, supplying turbidity currents loaded with a wide spectrum of grain sizes. Turbiditic deposition makes that record at a given site is discontinuous which was the reason for an E-W transect approach. Exp. 354 drilled seven sites along a 320 km E-W transect at 8°N allowing the restitution of an almost complete record of Himalayan erosion at the scale of the Neogene. In spite of the transect's extension, a long absence of deposition was observed between 0.6 to 1.2 Ma indicating that turbiditic depocenter was derived more to the West for ca. 600 kyr. Turbidites have clear Himalayan origin with close mineralogical and isotopic analogy with those of the modern Ganga-Brahmaputra river sediments. Geochemistry shows relatively stable compositions throughout the Neogene and Quaternary and reveal a very weak regime of chemical weathering with no significant variation through time. Concentrations in mobile elements such as Na and K relative to Al are significantly higher than in modern sediments suggesting that weathering is amplified in the modern time. Low weathering of the sediments at 8°N indicates that erosion was dominated by physical processes and that transport is rapid enough to prevent evolution of particles in the floodplain. In the modern Himalaya, low weathering is achieved primarily by landslides and rapid transfer through the floodplain, i.e. limited recycling of sediment deposited in the floodplain. Both processes are favoured by the seasonality and the intensity of the monsoon. Although relatively stable, source tracers such as Sr-Nd isotopic compositions, and detrital carbonate compositions show organised variations with time

  3. Structure and builtup of the Middle Bengal Fan at 8°N from multichannel seismic surveys and the IODP Expedition 354 drilling transect

    NASA Astrophysics Data System (ADS)

    Spiess, V.; Bergmann, F.; Schwenk, T.; Lantzsch, H.; Bahk, J. J.; Weber, M. E.; France-Lanord, C.; Klaus, A.

    2016-12-01

    IODP Expedition 354 to the Bengal Fan drilled a 320 km long e-W transect at 8°N with 7 drill sites, fully covering the uppermost 150-200 meters of fan deposits at distances of 50 km, originating from Himalayan mountain ranges and the Ganges-Brahmaputra river system. A major goal of this transect approach was to ensure a continuous record of turbiditic material delivered over the last appx. 1 million year, considering frequent longitudinal depocenter shifts of the active channel. By extensively utilizing the new half-APC coring technique, high quality and high recovery cores could be retrieved representing a wide range of grain sizes from hemipelagic deposits through clay rich turbidites to coarse silt and sandy units. Up to medium sand grain sizes were retrieved within the basal units of levees, which correspond to high-reflectivity units in high-resolution multichannel seismic profiles. Finely laminated sections with mm to cm-thick turbidites represents levee formations. At Site U1453 for example, core logging and downhole logging data confirm the representative sampling based on a very good match of several physical property data sets. An expanded section was cored at Site U1454, where the presumably currently active channel has built a levee, which likely represents major sediment supply within the last 30 kyr. A spatial grid of seismic and echosounder data in the vicinity of the active channel reveals a high spatial variability in sedimentation rates and distinct depocenter shifts in response to changes in channel geometry. Site U1452 has provided a full record a levee growth including interlevee sedimentation, sandy basal units characterized by a lobe formation, and a pronounced fining upward trend following the phase of channel erosion and levee builtup. From all sites, detailed comparisons of physical and sedimentological shipboard results with seismic data will be presented. Expedition 354 has provided a unique sample and data set to better understand fan

  4. Impact of treatment with melatonin on cerebral circulation in old rats

    PubMed Central

    Dupuis, François; Régrigny, Olivier; Atkinson, Jeffrey; Limiñana, Patrick; Delagrange, Philippe; Scalbert, Elizabeth; Chillon, Jean-Marc

    2004-01-01

    Melatonin deprival in young rats induces alterations in cerebral arteriolar wall similar to those observed during aging: atrophy and a decrease in distensibility. In this study, we examined the effects of melatonin treatment on cerebral arteriolar structure and distensibility and on the lower limit of cerebral blood flow autoregulation (LLCBF) in old rats. We measured cerebral blood flow (arbitrary unit, laser Doppler, open skull preparation) prior to and during stepwise hypotension (SH) in adult (12/13 months) and old (24/25 months) IcoWI and WAG/Rij male rats. Old rats were untreated or treated for 3 months with melatonin (0.39 (IcoWi) and 0.44 (Wag/Rij) mg kg−1 day−1, drinking water). Stress–strain relationships were determined using cross-sectional area (CSA, μm2, histometry) and values of arteriolar internal diameter (μm) obtained during a second SH following arteriolar deactivation (EDTA, 67 mmol l−1). Aging induced (a) atrophy of the arteriolar wall in IcoWI (616±20 vs 500±27 μm2, P<0.05) but not in WAG/Rij rats (328±25 vs 341±20 μm2), (b) a decrease in arteriolar wall distensibility and (c) an increase in the LLCBF in both strains (67±10 mmHg in 12-month-old vs 95±6 mmHg in 24-month-old IcoWi, P<0.05 and 53±2 mmHg in 13-month-old vs 67±6 mmHg in 25-month-old WAG/Rij). Melatonin treatment induced in IcoWI and WAG/Rij rats (a) hypertrophy of the arteriolar wall (643±34 and 435±25 μm2, respectively), (b) an increase in arteriolar wall distensibility and (c) a decrease in the LLCBF (64±6 and 45±4 mmHg, respectively). Melatonin treatment of old rats induced hypertrophy of the arteriolar wall, prevented the age-linked decrease in cerebral arteriolar distensibility and decreased the LLCBF. PMID:14718260

  5. SPECTRUM OF DISEASE AND OUTCOME OF PRIMARY AMPUTATION FOR DIABETIC FOOT SEPSIS.

    PubMed

    Cheddie, S; Manneh, C; Zulu, H

    2017-09-01

    Guillotine amputation for diabetic foot sepsis followed by an elective refashioning of the stump is regarded as standard practice. Primary amputation is associated with higher reamputation rates. A prospective cohort study of 85 patients who underwent surgery for diabetic foot sepsis from 2014 to 2016 at Madadeni Provincial Hospital, KwaZulu-Natal was done. Ethical approval was granted. The Wagner classification (Wag) was used to classify disease severity. Outcome measures included length of hospital stay, mortality and re-amputation rates. Of the 85 patients, females (n=45) accounted for 53% of admissions. The mean age was 61 years (range: 29 to 80 years). The majority of patients were African, n=75 (88%). Only 1 patient presented with diabetic ketoacidosis and 18 (21%) presented with renal failure. Most patients presented with advanced disease: [Wag 5, n=66 (78%); Wag 4, n=12 (14%); Wag 3, n=5 (6%); Wag 2, n=2 (2%)]. The levels of vascular occlusion included aortoiliac disease n=2 (2%), femoro-popliteal disease n=18 (21%), tibio-peroneal disease n=65 (76%). Radiographic features included normal findings n=60 (71%); gas gangrene n=11 (13%), osteitis n=8 (9%). The following amputations were done: AKA, n=29 (34%); BKA, n=39 (46%); TMA, n=8 (9%); Toe-ectomy, n=5 (6%) and Debridement, n=4 (5%). The re-amputation rate to above knee amputation was n= 3/39 (8%). All AKA stumps healed well. The overall in-hospital mortality was n=5 (6%) and mean length of hospital stay was 7.8 days ±3.83. The majority of patients presented with advanced disease requiring a major amputation. A definitive one stage primary amputation is a safe and effective procedure for diabetic foot sepsis and is associated with a low re-amputation rate, length of hospital stay and mortality. A guillotine amputation should be reserved for physiologically unstable patients.

  6. The effect of oil spills on the bacterial diversity and catabolic function in coastal sediments: a case study on the Prestige oil spill.

    PubMed

    Acosta-González, Alejandro; Martirani-von Abercron, Sophie-Marie; Rosselló-Móra, Ramon; Wittich, Regina-Michaela; Marqués, Silvia

    2015-10-01

    The accident of the Prestige oil tanker in 2002 contaminated approximately 900 km of the coastline along the northern Spanish shore, as well as parts of Portugal and France coast, with a mixture of heavy crude oil consisting of polycyclic aromatic hydrocarbons, alkanes, asphaltenes and resins. The capacity of the autochthonous bacterial communities to respond to the oil spill was assessed indirectly by determining the hydrocarbon profiles of weathered oil samples collected along the shore, as well as through isotope ratios of seawater-dissolved CO2, and directly by analyses of denaturing gradient gel electrophoresis fingerprints and 16S rRNA gene libraries. Overall, the results evidenced biodegradation of crude oil components mediated by natural bacterial communities, with a bias towards lighter and less substituted compounds. The changes observed in the Proteobacteria, the most abundant phylum in marine sediments, were related to the metabolic profiles of the sediment. The presence of crude oil in the supratidal and intertidal zones increased the abundance of Alpha- and Gammaproteobacteria, dominated by the groups Sphingomonadaceae, Rhodobacteraceae and Chromatiales, whilst Gamma- and Deltaproteobacteria were more relevant in subtidal zones. The phylum Actinobacteria, and particularly the genus Rhodococcus, was a key player in the microbial response to the spill, especially in the degradation of the alkane fraction. The addition of inorganic fertilizers enhanced total biodegradation rates, suggesting that, in these environments, nutrients were insufficient to support significant growth after the huge increase in carbon sources, as evidenced in other spills. The presence of bacterial communities able to respond to a massive oil input in this area was consistent with the important history of pollution of the region by crude oil.

  7. 9 CFR 354.241 - Cleaning of rooms and compartments.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... skinning room shall be kept clean and free from offensive odors at all times. (g) The walls, floors, and all equipment and utensils used in the killing and skinning room shall be thoroughly washed and cleaned after each day's operation. (h) The floor in the killing and skinning rooms shall be cleaned...

  8. 9 CFR 354.241 - Cleaning of rooms and compartments.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... skinning room shall be kept clean and free from offensive odors at all times. (g) The walls, floors, and all equipment and utensils used in the killing and skinning room shall be thoroughly washed and cleaned after each day's operation. (h) The floor in the killing and skinning rooms shall be cleaned...

  9. Paleoceanographic history of the Lower Bengal Fan during the last glacial cycle - IODP Expedition 354

    NASA Astrophysics Data System (ADS)

    Dekens, P. S.; Weber, M. E.; Lantzsch, H.; Das, S. K.; Williams, T.; Adhikari, R. R.; Jia, G.; Fox, L. R.; Ge, J.; Manoj, M. C.; Savian, J. F.; Reilly, B. T.; Selkin, P. A.; Meynadier, L.; Spiess, V.; France-Lanord, C.; Sharma, B.

    2015-12-01

    IODP Expedition 354 drilled a ~320 km long transect of seven sites on the Lower Bengal Fan at 8o N in the Northern Indian Ocean. The sediments cores recovered record a complex relationship between turbiditic and hemipelagic environments. This variability offers a unique opportunity to link our understanding of tectonic and terrestrial processes with climate and oceanography. With the exception the westernmost Site U1454, all sites show a several meter thick, hemipelagic top layer, usually representing Late Quaternary sediment. We present physical, geochemical and stable isotopic properties of this interval to establish a time frame and assess the paleoceanographic development of the region during the last glacial cycle. We sampled Site U1452C-1H continuously for the uppermost 480 cm of hemipelagic sediment in 2-cm increments. Preliminary results indicate the Toba Ash 1 (0.74 ka) is a distinct time marker in all physical properties. Furthermore, wet-bulk density as well as color reflectance b* (the red-green component) and L* (the lightness) show a dominant precession cyclicity. Hence, we are able to provide an insolation-tuned chronology for the last 200 ka (MIS1 - 7) as a preliminary age model. These records agree well with d18O records retrieved from Chinese caves. We will present a preliminary paleoceanographic proxy data to reconstruct sea-surface temperature (SST), sea-surface salinity (SSS), ice volume, marine biological productivity, nutrient supply, and deep-water circulation. These oceanographic and climate conditions are linked to changes in monsoonal strength and terrestrial input using sedimentary proxies to reconstruct chemical weathering and sediment sources and transport time. This work addresses one of the primary cruise objectives - linking monsoon variability, regional and global climate, and Bay of Bengal sediment deposition.

  10. Association of medical student burnout with residency specialty choice.

    PubMed

    Enoch, Lindsey; Chibnall, John T; Schindler, Debra L; Slavin, Stuart J

    2013-02-01

    Given the trend among medical students away from primary care medicine and toward specialties that allow for more controllable lifestyles, the identification of factors associated with specialty choice is important. Burnout is one such factor. The purpose of this study was to examine the associations between burnout and residency specialty choice in terms of provision for a less versus more controllable lifestyle (e.g. internal medicine versus dermatology) and a lower versus higher income (e.g. paediatrics versus anaesthesiology). A survey was sent to 165 Year 4 medical students who had entered the residency matching system. Students answered questions about specialty choice, motivating factors (lifestyle, patient care and prestige) and perceptions of medicine as a profession. They completed the Maslach Burnout Inventory-Human Services (MBI), which defines burnout in relation to emotional exhaustion (EE), depersonalisation (DP) and personal accomplishment (PA). Burnout and other variables were tested for associations with specialty lifestyle controllability and income. A response rate of 88% (n = 145) was achieved. Experiences of MBI-EE, MBI-DP and MBI-PA burnout were reported by 42 (29%), 26 (18%) and 30 (21%) students, respectively. Specialties with less controllable lifestyles were chosen by 87 (60%) students and lower-income specialties by 81 (56%). Adjusted odds ratios (ORs) indicated that the choice of a specialty with a more controllable lifestyle was associated with higher MBI-EE burnout (OR = 1.77, 95% confidence interval [CI] 1.06-2.96), as well as stronger lifestyle- and prestige-related motivation, and weaker patient care-related motivation. The choice of a higher-income specialty was associated with lower MBI-PA burnout (OR = 0.56, 95% CI 0.32-0.98), weaker lifestyle- and patient care-related motivation, and stronger prestige-related motivation. Specialty choices regarding lifestyle controllability and income were associated with the amount and type of

  11. Suppression of long-branch attraction artefacts in the animal phylogeny using a site-heterogeneous model

    PubMed Central

    Lartillot, Nicolas; Brinkmann, Henner; Philippe, Hervé

    2007-01-01

    Background Thanks to the large amount of signal contained in genome-wide sequence alignments, phylogenomic analyses are converging towards highly supported trees. However, high statistical support does not imply that the tree is accurate. Systematic errors, such as the Long Branch Attraction (LBA) artefact, can be misleading, in particular when the taxon sampling is poor, or the outgroup is distant. In an otherwise consistent probabilistic framework, systematic errors in genome-wide analyses can be traced back to model mis-specification problems, which suggests that better models of sequence evolution should be devised, that would be more robust to tree reconstruction artefacts, even under the most challenging conditions. Methods We focus on a well characterized LBA artefact analyzed in a previous phylogenomic study of the metazoan tree, in which two fast-evolving animal phyla, nematodes and platyhelminths, emerge either at the base of all other Bilateria, or within protostomes, depending on the outgroup. We use this artefactual result as a case study for comparing the robustness of two alternative models: a standard, site-homogeneous model, based on an empirical matrix of amino-acid replacement (WAG), and a site-heterogeneous mixture model (CAT). In parallel, we propose a posterior predictive test, allowing one to measure how well a model acknowledges sequence saturation. Results Adopting a Bayesian framework, we show that the LBA artefact observed under WAG disappears when the site-heterogeneous model CAT is used. Using cross-validation, we further demonstrate that CAT has a better statistical fit than WAG on this data set. Finally, using our statistical goodness-of-fit test, we show that CAT, but not WAG, correctly accounts for the overall level of saturation, and that this is due to a better estimation of site-specific amino-acid preferences. Conclusion The CAT model appears to be more robust than WAG against LBA artefacts, essentially because it correctly

  12. Postoperative environmental anesthetic vapour concentrations following removal of the airway device in the operating room versus the postanesthesia care unit.

    PubMed

    Cheung, Sara K; Özelsel, Timur; Rashiq, Saifee; Tsui, Ban C

    2016-09-01

    This study was designed to compare waste anesthetic gas (WAG) concentrations within patients' breathing zones after removal of the patient's airway device in the postanesthesia care unit (PACU) vs in the operating room (OR). Following Research Ethics Board approval and patient consent, we recruited patients undergoing surgery who received volatile anesthesia via an endotracheal tube or supraglottic airway. Patients had their airway device removed in the OR or in the PACU depending on the attending anesthesiologist's preference. Upon the patient's arrival in the PACU, concentrations of exhaled sevoflurane and desflurane were measured at their breathing zone (i.e., 15 cm from the patient's mouth and nose) using a single-beam infrared spectrophotometer. Seventy patients were recruited during the five-month study period. The median [interquartile range] WAG levels in the patients' breathing zones were higher when their airway devices were removed in the PACU vs in the OR. The WAG levels for sevoflurane were 0.7 [0.4-1.1] parts per million (ppm) vs 0.5 [0.4-0.7] ppm, respectively; median difference, 0.3; 95% confidence interval (CI), 0.1 to 0.6; P = 0.04. The WAG levels for desflurane were 2.4 [1.2-3.4] ppm vs 4.1 [2.5-5.2] ppm, respectively; median difference, 1.5; 95% CI, 0.3 to 2.7; P = 0.04. After a volatile-based anesthetic, our results suggest that removal of the airway device in the PACU vs in the OR increases the amount of waste anesthetic gas in a patient's breathing zone and thus potentially in the PACU nurse's working zone.

  13. Secondary Students' Writing Achievement Goals: Assessing the Mediating Effects of Mastery and Performance Goals on Writing Self-Efficacy, Affect, and Writing Achievement

    PubMed Central

    Yilmaz Soylu, Meryem; Zeleny, Mary G.; Zhao, Ruomeng; Bruning, Roger H.; Dempsey, Michael S.; Kauffman, Douglas F.

    2017-01-01

    The two studies reported here explored the factor structure of the newly constructed Writing Achievement Goal Scale (WAGS), and examined relationships among secondary students' writing achievement goals, writing self-efficacy, affect for writing, and writing achievement. In the first study, 697 middle school students completed the WAGS. A confirmatory factor analysis revealed a good fit for this data with a three-factor model that corresponds with mastery, performance approach, and performance avoidance goals. The results of Study 1 were an indication for the researchers to move forward with Study 2, which included 563 high school students. The secondary students completed the WAGS, as well as the Self-efficacy for Writing Scale, and the Liking Writing Scale. Students also self-reported grades for writing and for language arts courses. Approximately 6 weeks later, students completed a statewide writing assessment. We tested a theoretical model representing relationships among Study 2 variables using structural equation modeling including students' responses to the study scales and students' scores on the statewide assessment. Results from Study 2 revealed a good fit between a model depicting proposed relationships among the constructs and the data. Findings are discussed relative to achievement goal theory and writing. PMID:28878707

  14. Variations of the Indian summer monsoon over the Mio-Pliocene recorded in the Bengal Fan (IODP Exp354): implications for the evolution of the terrestrial biosphere.

    NASA Astrophysics Data System (ADS)

    Galy, Valier; Feakins, Sarah; Karkabi, Elias; Ponton, Camilo; Galy, Albert; France-Lanord, Christian

    2017-04-01

    A pressing challenge in climate research is understanding the temporal evolution of the Indian monsoon system; its response to global and regional climatic controls (including warming); as well as implications in terms of vegetation (C4 expansion), erosion of the Himalaya and carbon sequestration in the Bengal Fan. Studies on climate dynamics have recently offered new insights into the mechanistic controls on the monsoon: the tectonic boundary of the Himalaya is implicated as the major control on Indian summer monsoon dynamics today. Since this region has been uplifted since at least the late Oligocene, it is possible to test the response of monsoon precipitation to global and regional climate change, and also understand feedbacks on the climate system via carbon sequestration in the Bengal Fan. The evidence for monsoon intensity changes across the Miocene and Pliocene is currently incomplete given temporal uncertainty and diagenesis in terrestrial records; biases in the records reconstructed from the distal fan; and conflicting evidence from wind speed and aridity metrics for a stronger or weaker monsoon. Our alternative approach is therefore to study the basin-wide hydrological changes recorded in a multi-proxy, multi-site study of the marine sediments of the Bengal Fan recovered during IODP expedition 354. In turbiditic sediments of Himalayan origin, the late Miocene C4 expansion was found in all three long records recovered during expedition 354 (i.e. at sites U1451, U1450 and U1455, from East to West) based on stable carbon isotope composition of terrestrial leaf-wax compounds. Cores from sites U1455 (a reoccupation of DSDP Leg 22 Site 218) provide the highest resolution record of the C4 transition, which appears to occur abruptly within a relatively continuous series of turbiditic sequences. Bio- and magneto-stratigraphic dating of these records by members of Expedition 354 science party is underway and will provide the best stratigraphic constraint of the C4

  15. Refining the Bengal Fan stratigraphy - A first correlation of IODP Expedition 354 results and seismic data from the Bay of Bengal

    NASA Astrophysics Data System (ADS)

    Schwenk, Tilmann; Spiess, Volkhard; Bergmann, Fenna; France-Lanord, Christian; Klaus, Adam

    2016-04-01

    The Bengal Fan covers the floor of the entire Bay of Bengal from the continental margins of India and Bangladesh to the sediment-filled Sunda Trench off Myanmar and the Andaman Islands, and along the west side of the Ninetyeast Ridge. The deposition and progradation of the Bengal Fan started in the Eocene after the collision of India with Asia resulting in the build-up of the Himalaya and the formation of a large proto-Bay of Bengal. Continued convergence of the Indian and Australian plates with the Southeast Asian plate reduced the size of the bay and focused the source of turbidites finally into the present Bengal Basin, Bangladesh shelf, and the shelf canyon "Swatch of no Ground". Today, the Bengal Fan is mainly fed by the sediment load of the Ganges and Brahmaputra rivers, which drain the Himalayas at its southern and northern slope, respectively, and deliver their load to the delta in the Bengal Basin, to the Bengal Shelf and to the deep sea fan. Thus the Bengal Fan is a suitable recorder to study interactions among the growth of the Himalaya and Tibet, the development of the Asian monsoon, and processes affecting the carbon cycle and global climate. Because sedimentation in the Bengal Fan responds to both, climate and tectonic processes, its terrigenous sediment records the past evolution of both the Himalaya and regional climate. This evolution is also expressed in the stratigraphy of the fan in terms of unconformities and key horizons, average sedimentation rates as a function of distance from the basement ridges at 85°E and 90°E and the presence or absence of channel-levee systems. The histories of the Himalaya/Tibetan system and the Asian monsoon require sampling different periods of time with different levels of precision. Therefore IODP Expedition 354 drilled in February-March 2015 a seven site, 320 km-long transect across the Bengal Fan at 8°N. This strategy has been chosen because sediment transport took place by turbidity currents following

  16. Electrical transport properties and giant baroresistance effect at martensitic transformation of Ni43.7Fe5.3Mn35.4In15.6 Heusler alloy

    NASA Astrophysics Data System (ADS)

    Zhang, Yuanlei; He, Xijia; Li, Zhe; Xu, Kun; Liu, Changqin; Huang, Yinsheng; Jing, Chao

    2018-04-01

    The electrical transport properties at martensitic transformation (MT) in polycrystalline Ni43.7Fe5.3Mn35.4In15.6 have been intensively investigated under different hydrostatic pressures. For this alloy, the experimental results show that applying a higher hydrostatic pressure can convert its MT from the metamagnetic type into the paramagnetic type. It provides a unique opportunity to separate the relative contributions of electron-spin and electron-lattice scatterings across the metamagnetic MT based on the dynamical Clausius-Clapeyron equation, which delivers a deeper insight into the resistivity change of metamagnetic MT for the Mn-rich Ni-Mn based Heusler alloys. In addition, the studied alloy also reveals a giant positive baroresistance (BR) effect with a saturated value of 115% at 242 K. This performance originates from the combined effect of electron-spin and electron-lattice scatterings associated with a prominent hydrostatic pressure-induced MT, which contribute 46% and 69% to the overall BR ratio, respectively.

  17. Incorporating Non-Relevance Information in the Estimation of Query Models

    DTIC Science & Technology

    2008-11-01

    experiments in relevance feedback. In Salton , G., editor, The SMART Retrieval System – Exper- iments in Automatic Document Processing, pages 337– 354...W. (2001). Relevance based lan- guage models. In SIGIR ’01. Rocchio, J. (1971). Relevance feedback in information re- trieval. In Salton , G., editor

  18. Big Data and Dysmenorrhea: What Questions Do Women and Men Ask About Menstrual Pain?

    PubMed

    Chen, Chen X; Groves, Doyle; Miller, Wendy R; Carpenter, Janet S

    2018-04-30

    Menstrual pain is highly prevalent among women of reproductive age. As the general public increasingly obtains health information online, Big Data from online platforms provide novel sources to understand the public's perspectives and information needs about menstrual pain. The study's purpose was to describe salient queries about dysmenorrhea using Big Data from a question and answer platform. We performed text-mining of 1.9 billion queries from ChaCha, a United States-based question and answer platform. Dysmenorrhea-related queries were identified by using keyword searching. Each relevant query was split into token words (i.e., meaningful words or phrases) and stop words (i.e., not meaningful functional words). Word Adjacency Graph (WAG) modeling was used to detect clusters of queries and visualize the range of dysmenorrhea-related topics. We constructed two WAG models respectively from queries by women of reproductive age and bymen. Salient themes were identified through inspecting clusters of WAG models. We identified two subsets of queries: Subset 1 contained 507,327 queries from women aged 13-50 years. Subset 2 contained 113,888 queries from men aged 13 or above. WAG modeling revealed topic clusters for each subset. Between female and male subsets, topic clusters overlapped on dysmenorrhea symptoms and management. Among female queries, there were distinctive topics on approaching menstrual pain at school and menstrual pain-related conditions; while among male queries, there was a distinctive cluster of queries on menstrual pain from male's perspectives. Big Data mining of the ChaCha ® question and answer service revealed a series of information needs among women and men on menstrual pain. Findings may be useful in structuring the content and informing the delivery platform for educational interventions.

  19. 7 CFR 1980.497 - General administrative.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... Law 103-354 Office) for advice on how to interact with the OGC on liquidations and property management... inventory and accounts receivable. (iv) Litigation is pending or threatened: e.g., bankruptcy, other...

  20. 7 CFR 1980.497 - General administrative.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... Law 103-354 Office) for advice on how to interact with the OGC on liquidations and property management... inventory and accounts receivable. (iv) Litigation is pending or threatened: e.g., bankruptcy, other...

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