76 FR 41234 - Basic Energy Sciences Advisory Committee

Federal Register 2010, 2011, 2012, 2013, 2014

2011-07-13

... DEPARTMENT OF ENERGY Basic Energy Sciences Advisory Committee AGENCY: Department of Energy, Office of Science. ACTION: Notice of open meeting. SUMMARY: This notice announces a meeting of the Basic Energy Sciences Advisory Committee (BESAC). Federal Advisory Committee Act (Pub. L. 92- 463, 86 Stat. 770...

77 FR 41395 - Basic Energy Sciences Advisory Committee

Federal Register 2010, 2011, 2012, 2013, 2014

2012-07-13

... DEPARTMENT OF ENERGY Basic Energy Sciences Advisory Committee AGENCY: Department of Energy, Office of Science. ACTION: Notice of open meeting. SUMMARY: This notice announces a meeting of the Basic Energy Sciences Advisory Committee (BESAC). Federal Advisory Committee Act (Pub. L. 92- 463, 86 Stat. 770...

75 FR 41838 - Basic Energy Sciences Advisory Committee

Federal Register 2010, 2011, 2012, 2013, 2014

2010-07-19

... DEPARTMENT OF ENERGY Basic Energy Sciences Advisory Committee AGENCY: Department of Energy, Office of Science. ACTION: Notice of Open Meeting. SUMMARY: This notice announces a meeting of the Basic Energy Sciences Advisory Committee (BESAC). The Federal Advisory Committee Act (Pub. L. 92-463, 86 Stat...

76 FR 8358 - Basic Energy Sciences Advisory Committee

Federal Register 2010, 2011, 2012, 2013, 2014

2011-02-14

... DEPARTMENT OF ENERGY Basic Energy Sciences Advisory Committee AGENCY: Department of Energy, Office of Science. ACTION: Notice of open meeting. SUMMARY: This notice announces a meeting of the Basic Energy Sciences Advisory Committee (BESAC). Federal Advisory Committee Act (Pub. L. 92- 463, 86 Stat. 770...

The use of simulation in teaching the basic sciences.

PubMed

Eason, Martin P

2013-12-01

To assess the current use of simulation in medical education, specifically, the teaching of the basic sciences to accomplish the goal of improved integration. Simulation is increasingly being used by the institutions to teach the basic sciences. Preliminary data suggest that it is an effective tool with increased retention and learner satisfaction. Medical education is undergoing tremendous change. One of the directions of that change is increasing integration of the basic and clinical sciences to improve the efficiency and quality of medical education, and ultimately to improve the patient care. Integration is thought to improve the understanding of basic science conceptual knowledge and to better prepare the learners for clinical practice. Simulation because of its unique effects on learning is currently being successfully used by many institutions as a means to produce that integration through its use in the teaching of the basic sciences. Preliminary data indicate that simulation is an effective tool for basic science education and garners high learner satisfaction.

Back to the basic sciences: an innovative approach to teaching senior medical students how best to integrate basic science and clinical medicine.

PubMed

Spencer, Abby L; Brosenitsch, Teresa; Levine, Arthur S; Kanter, Steven L

2008-07-01

Abraham Flexner persuaded the medical establishment of his time that teaching the sciences, from basic to clinical, should be a critical component of the medical student curriculum, thus giving rise to the "preclinical curriculum." However, students' retention of basic science material after the preclinical years is generally poor. The authors believe that revisiting the basic sciences in the fourth year can enhance understanding of clinical medicine and further students' understanding of how the two fields integrate. With this in mind, a return to the basic sciences during the fourth year of medical school may be highly beneficial. The purpose of this article is to (1) discuss efforts to integrate basic science into the clinical years of medical student education throughout the United States and Canada, and (2) describe the highly developed fourth-year basic science integration program at the University of Pittsburgh School of Medicine. In their critical review of medical school curricula of 126 U.S. and 17 Canadian medical schools, the authors found that only 19% of U.S. medical schools and 24% of Canadian medical schools require basic science courses or experiences during the clinical years, a minor increase compared with 1985. Curricular methods ranged from simple lectures to integrated case studies with hands-on laboratory experience. The authors hope to advance the national discussion about the need to more fully integrate basic science teaching throughout all four years of the medical student curriculum by placing a curricular innovation in the context of similar efforts by other U.S. and Canadian medical schools.

78 FR 47677 - Basic Energy Sciences Advisory Committee

Federal Register 2010, 2011, 2012, 2013, 2014

2013-08-06

... DEPARTMENT OF ENERGY Basic Energy Sciences Advisory Committee AGENCY: Office of Science, Department of Energy. ACTION: Notice of renewal. SUMMARY: Pursuant to Section 14(a)(2)(A) of the Federal... hereby given that the Basic Energy Sciences Advisory Committee's (BESAC) charter will be renewed for a...

Basic Sciences Fertilizing Clinical Microbiology and Infection Management.

PubMed

Baquero, Fernando

2017-08-15

Basic sciences constitute the most abundant sources of creativity and innovation, as they are based on the passion of knowing. Basic knowledge, in close and fertile contact with medical and public health needs, produces distinct advancements in applied sciences. Basic sciences play the role of stem cells, providing material and semantics to construct differentiated tissues and organisms and enabling specialized functions and applications. However, eventually processes of "practice deconstruction" might reveal basic questions, as in de-differentiation of tissue cells. Basic sciences, microbiology, infectious diseases, and public health constitute an epistemological gradient that should also be an investigational continuum. The coexistence of all these interests and their cross-fertilization should be favored by interdisciplinary, integrative research organizations working simultaneously in the analytical and synthetic dimensions of scientific knowledge. © The Author 2017. Published by Oxford University Press for the Infectious Diseases Society of America.

Integration of basic sciences and clinical sciences in oral radiology education for dental students.

PubMed

Baghdady, Mariam T; Carnahan, Heather; Lam, Ernest W N; Woods, Nicole N

2013-06-01

Educational research suggests that cognitive processing in diagnostic radiology requires a solid foundation in the basic sciences and knowledge of the radiological changes associated with disease. Although it is generally assumed that dental students must acquire both sets of knowledge, little is known about the most effective way to teach them. Currently, the basic and clinical sciences are taught separately. This study was conducted to compare the diagnostic accuracy of students when taught basic sciences segregated or integrated with clinical features. Predoctoral dental students (n=51) were taught four confusable intrabony abnormalities using basic science descriptions integrated with the radiographic features or taught segregated from the radiographic features. The students were tested with diagnostic images, and memory tests were performed immediately after learning and one week later. On immediate and delayed testing, participants in the integrated basic science group outperformed those from the segregated group. A main effect of learning condition was found to be significant (p<0.05). The results of this study support the critical role of integrating biomedical knowledge in diagnostic radiology and shows that teaching basic sciences integrated with clinical features produces higher diagnostic accuracy in novices than teaching basic sciences segregated from clinical features.

Basic Science Living Skills for Today's World. Teacher's Edition.

ERIC Educational Resources Information Center

Zellers (Robert W.) Educational Services, Johnstown, PA.

This document is a teacher's edition of a basic skills curriculum in science for adult basic education (ABE) students. The course consists of 25 lessons on basic science concepts, designed to give students a good understanding of the biological and physical sciences. Suggested activities and experiments that the student can do are also included.…

Clinical Competencies and the Basic Sciences: An Online Case Tutorial Paradigm for Delivery of Integrated Clinical and Basic Science Content

ERIC Educational Resources Information Center

DiLullo, Camille; Morris, Harry J.; Kriebel, Richard M.

2009-01-01

Understanding the relevance of basic science knowledge in the determination of patient assessment, diagnosis, and treatment is critical to good medical practice. One method often used to direct students in the fundamental process of integrating basic science and clinical information is problem-based learning (PBL). The faculty facilitated small…

Evaluation of Fast-Time Wake Vortex Prediction Models

NASA Technical Reports Server (NTRS)

Proctor, Fred H.; Hamilton, David W.

2009-01-01

Current fast-time wake models are reviewed and three basic types are defined. Predictions from several of the fast-time models are compared. Previous statistical evaluations of the APA-Sarpkaya and D2P fast-time models are discussed. Root Mean Square errors between fast-time model predictions and Lidar wake measurements are examined for a 24 hr period at Denver International Airport. Shortcomings in current methodology for evaluating wake errors are also discussed.

Contributions of Basic Sciences to Science of Education. Studies in Educational Administration.

ERIC Educational Resources Information Center

Lall, Bernard M.

The science of education has been influenced by the basic sciences to the extent that educational research now has been able to modernize its approach by accepting and using the basic scientific methodology and experimental techniques. Using primarily the same steps of scientific investigations, education today holds a place of much greater esteem…

Integration and timing of basic and clinical sciences education.

PubMed

Bandiera, Glen; Boucher, Andree; Neville, Alan; Kuper, Ayelet; Hodges, Brian

2013-05-01

Medical education has traditionally been compartmentalized into basic and clinical sciences, with the latter being viewed as the skillful application of the former. Over time, the relevance of basic sciences has become defined by their role in supporting clinical problem solving rather than being, of themselves, a defining knowledge base of physicians. As part of the national Future of Medical Education in Canada (FMEC MD) project, a comprehensive empirical environmental scan identified the timing and integration of basic sciences as a key pressing issue for medical education. Using the literature review, key informant interviews, stakeholder meetings, and subsequent consultation forums from the FMEC project, this paper details the empirical basis for focusing on the role of basic science, the evidentiary foundations for current practices, and the implications for medical education. Despite a dearth of definitive relevant studies, opinions about how best to integrate the sciences remain strong. Resource allocation, political power, educational philosophy, and the shift from a knowledge-based to a problem-solving profession all influence the debate. There was little disagreement that both sciences are important, that many traditional models emphasized deep understanding of limited basic science disciplines at the expense of other relevant content such as social sciences, or that teaching the sciences contemporaneously rather than sequentially has theoretical and practical merit. Innovations in integrated curriculum design have occurred internationally. Less clear are the appropriate balance of the sciences, the best integration model, and solutions to the political and practical challenges of integrated curricula. New curricula tend to emphasize integration, development of more diverse physician competencies, and preparation of physicians to adapt to evolving technology and patients' expectations. Refocusing the basic/clinical dichotomy to a foundational

Basic Principles of Animal Science. Reprinted.

ERIC Educational Resources Information Center

Florida State Dept. of Education, Tallahassee.

The reference book is designed to fulfill the need for organized subject matter dealing with basic principles of animal science to be incorporated into the high school agriculture curriculum. The material presented is scientific knowledge basic to livestock production. Five units contain specific information on the following topics: anatomy and…

Review of Idealized Aircraft Wake Vortex Models

NASA Technical Reports Server (NTRS)

Ahmad, Nashat N.; Proctor, Fred H.; Duparcmeur, Fanny M. Limon; Jacob, Don

2014-01-01

Properties of three aircraft wake vortex models, Lamb-Oseen, Burnham-Hallock, and Proctor are reviewed. These idealized models are often used to initialize the aircraft wake vortex pair in large eddy simulations and in wake encounter hazard models, as well as to define matched filters for processing lidar observations of aircraft wake vortices. Basic parameters for each vortex model, such as peak tangential velocity and circulation strength as a function of vortex core radius size, are examined. The models are also compared using different vortex characterizations, such as the vorticity magnitude. Results of Euler and large eddy simulations are presented. The application of vortex models in the postprocessing of lidar observations is discussed.

Horizontal integration of the basic sciences in the chiropractic curriculum.

PubMed

Ward, Kevin P

2010-01-01

Basic science curricula at most chiropractic colleges consist of courses (eg, general anatomy, physiology, biochemistry, etc) that are taught as stand-alone content domains. The lack of integration between basic science disciplines causes difficulties for students who need to understand how the parts function together as an integrated whole and apply this understanding to solving clinical problems. More horizontally integrated basic science curricula could be achieved by several means: integrated Part I National Board of Chiropractic Examiners questions, a broader education for future professors, an increased emphasis on integration within the current model, linked courses, and an integrated, thematic basic science curriculum. Horizontally integrating basic science curricula would require significant efforts from administrators, curriculum committees, and instructional faculty. Once in place this curriculum would promote more clinically relevant learning, improved learning outcomes, and superior vertical integration.

Horizontal Integration of the Basic Sciences in the Chiropractic Curriculum

PubMed Central

Ward, Kevin P.

2010-01-01

Basic science curricula at most chiropractic colleges consist of courses (eg, general anatomy, physiology, biochemistry, etc) that are taught as stand-alone content domains. The lack of integration between basic science disciplines causes difficulties for students who need to understand how the parts function together as an integrated whole and apply this understanding to solving clinical problems. More horizontally integrated basic science curricula could be achieved by several means: integrated Part I National Board of Chiropractic Examiners questions, a broader education for future professors, an increased emphasis on integration within the current model, linked courses, and an integrated, thematic basic science curriculum. Horizontally integrating basic science curricula would require significant efforts from administrators, curriculum committees, and instructional faculty. Once in place this curriculum would promote more clinically relevant learning, improved learning outcomes, and superior vertical integration. PMID:21048882

Basic science in a predoctoral family practice curriculum.

PubMed

Davies, T C; Barnett, B L

1978-02-01

A course in applied basic science was designed with topic material organized according to anatomic body regions. Details of the diagnostic method were explained early in the course, and clinical procedures for data gathering and problem analyzing were followed while the significance of basic science knowledge in dealing with clinical situations was described. A collection of 35mm slides constituted the focal point of the course. The authors conducted the course together and an atmosphere of intellectual honesty was developed through open discussion between faculty and students. Student curiosity was respected and rewarded. Summaries of the discussions were prepared retrospectively by the faculty instructors for review gy the students. This experience proved that family physicians can demonstrate effectively the relevance of basic science to clinical medicine.

Exploring Attractiveness of the Basic Sciences for Female Physicians.

PubMed

Yamazaki, Yuka; Fukushima, Shinji; Kozono, Yuki; Uka, Takanori; Marui, Eiji

2018-01-01

In Japan, traditional gender roles of women, especially the role of motherhood, may cause early career resignations in female physicians and a shortage of female researchers. Besides this gender issue, a general physician shortage is affecting basic science fields. Our previous study suggested that female physicians could be good candidates for the basic sciences because such work offers good work-life balance. However, the attractiveness for female physicians of working in the basic sciences, including work-life balance, is not known. In a 2012 nationwide cross-sectional questionnaire survey, female physicians holding tenured positions in the basic sciences at Japan's medical schools were asked an open-ended question about positive aspects of basic sciences that clinical medicine lacks, and we analyzed 58 respondents' comments. Qualitative analysis using the Kawakita Jiro method revealed four positive aspects: research attractiveness, priority on research productivity, a healthy work-life balance, and exemption from clinical duties. The most consistent positive aspect was research attractiveness, which was heightened by medical knowledge and clinical experience. The other aspects were double-edged swords; for example, while the priority on research productivity resulted in less gender segregation, it sometimes created tough competition, and while exemption from clinical duties contributed to a healthy work-life balance, it sometimes lowered motivation as a physician and provided unstable income. Overall, if female physicians lack an intrinsic interest in research and seek good work-life balance, they may drop out of research fields. Respecting and cultivating students' research interest is critical to alleviating the physician shortage in the basic sciences.

Simulation of wind turbine wakes using the actuator line technique

PubMed Central

Sørensen, Jens N.; Mikkelsen, Robert F.; Henningson, Dan S.; Ivanell, Stefan; Sarmast, Sasan; Andersen, Søren J.

2015-01-01

The actuator line technique was introduced as a numerical tool to be employed in combination with large eddy simulations to enable the study of wakes and wake interaction in wind farms. The technique is today largely used for studying basic features of wakes as well as for making performance predictions of wind farms. In this paper, we give a short introduction to the wake problem and the actuator line methodology and present a study in which the technique is employed to determine the near-wake properties of wind turbines. The presented results include a comparison of experimental results of the wake characteristics of the flow around a three-bladed model wind turbine, the development of a simple analytical formula for determining the near-wake length behind a wind turbine and a detailed investigation of wake structures based on proper orthogonal decomposition analysis of numerically generated snapshots of the wake. PMID:25583862

Trends in Basic Sciences Education in Dental Schools, 1999-2016.

PubMed

Lantz, Marilyn S; Shuler, Charles F

2017-08-01

The purpose of this study was to examine data published over the past two decades to identify trends in the basic sciences curriculum in dental education, provide an analysis of those trends, and compare them with trends in the basic sciences curriculum in medical education. Data published from the American Dental Association (ADA) Surveys of Dental Education, American Dental Education Association (ADEA) Surveys of Dental School Seniors, and two additional surveys were examined. In large part, survey data collected focused on the structure, content, and instructional strategies used in dental education: what was taught and how. Great variability was noted in the total clock hours of instruction and the clock hours of basic sciences instruction reported by dental schools. Moreover, the participation of medical schools in the basic sciences education of dental students appears to have decreased dramatically over the past decade. Although modest progress has been made in implementing some of the curriculum changes recommended in the 1995 Institute of Medicine report such as integrated basic and clinical sciences curricula, adoption of active learning methods, and closer engagement with medical and other health professions education programs, educational effectiveness studies needed to generate data to support evidence-based approaches to curriculum reform are lacking. Overall, trends in the basic sciences curriculum in medical education were similar to those for dental education. Potential drivers of curriculum change were identified, as was recent work in other fields that should encourage reconsideration of dentistry's approach to basic sciences education. This article was written as part of the project "Advancing Dental Education in the 21st Century."

Clinical Correlations as a Tool in Basic Science Medical Education

PubMed Central

Klement, Brenda J.; Paulsen, Douglas F.; Wineski, Lawrence E.

2016-01-01

Clinical correlations are tools to assist students in associating basic science concepts with a medical application or disease. There are many forms of clinical correlations and many ways to use them in the classroom. Five types of clinical correlations that may be embedded within basic science courses have been identified and described. (1) Correlated examples consist of superficial clinical information or stories accompanying basic science concepts to make the information more interesting and relevant. (2) Interactive learning and demonstrations provide hands-on experiences or the demonstration of a clinical topic. (3) Specialized workshops have an application-based focus, are more specialized than typical laboratory sessions, and range in complexity from basic to advanced. (4) Small-group activities require groups of students, guided by faculty, to solve simple problems that relate basic science information to clinical topics. (5) Course-centered problem solving is a more advanced correlation activity than the others and focuses on recognition and treatment of clinical problems to promote clinical reasoning skills. Diverse teaching activities are used in basic science medical education, and those that include clinical relevance promote interest, communication, and collaboration, enhance knowledge retention, and help develop clinical reasoning skills. PMID:29349328

Translating orthopaedic basic science into clinical relevance.

PubMed

Madry, Henning

2014-12-01

In orthopaedic and trauma surgery, the rapid evolution of biomedical research has fundamentally changed the perception of the musculoskeletal system. Here, the rigor of basic science and the art of musculoskeletal surgery have come together to create a new discipline -experimental orthopaedics- that holds great promise for the causative cure of many orthopaedic conditions. The Journal of Experimental Orthopaedics intends to bridge the gap between orthopaedic basic science and clinical relevance, to allow for a fruitful clinical translation of excellent and important investigations in the field of the entire musculoskeletal system.

Basic Energy Sciences FY 2011 Research Summaries

DOE Office of Scientific and Technical Information (OSTI.GOV)

None

This report provides a collection of research abstracts for more than 1,300 research projects funded by the Office of Basic Energy Sciences (BES) in Fiscal Year 2011 at some 180 institutions across the U.S. This volume is organized along the three BES divisions: Materials Sciences and Engineering; Chemical Sciences, Geosciences, and Biosciences; and Scientific User Facilities.

Simulation of wind turbine wakes using the actuator line technique.

PubMed

Sørensen, Jens N; Mikkelsen, Robert F; Henningson, Dan S; Ivanell, Stefan; Sarmast, Sasan; Andersen, Søren J

2015-02-28

The actuator line technique was introduced as a numerical tool to be employed in combination with large eddy simulations to enable the study of wakes and wake interaction in wind farms. The technique is today largely used for studying basic features of wakes as well as for making performance predictions of wind farms. In this paper, we give a short introduction to the wake problem and the actuator line methodology and present a study in which the technique is employed to determine the near-wake properties of wind turbines. The presented results include a comparison of experimental results of the wake characteristics of the flow around a three-bladed model wind turbine, the development of a simple analytical formula for determining the near-wake length behind a wind turbine and a detailed investigation of wake structures based on proper orthogonal decomposition analysis of numerically generated snapshots of the wake. © 2015 The Author(s) Published by the Royal Society. All rights reserved.

Dopaminergic Modulation of Sleep-Wake States.

PubMed

Herrera-Solis, Andrea; Herrera-Morales, Wendy; Nunez-Jaramillo, Luis; Arias-Carrion, Oscar

2017-01-01

The role of dopamine in sleep-wake regulation is considered as a wakefulness-promoting agent. For the clinical treatment of excessive daytime sleepiness, drugs have been commonly used to increase dopamine release. However, sleep disorders or lack of sleep are related to several dopaminerelated disorders. The effects of dopaminergic agents, nevertheless, are mediated by two families of dopamine receptors, D1 and D2-like receptors; the first family increases adenylyl cyclase activity and the second inhibits adenylyl cyclase. For this reason, the dopaminergic agonist effects on sleep-wake cycle are complex. Here, we review the state-of-the-art and discuss the different effects of dopaminergic agonists in sleep-wake states, and propose that these receptors account for the affinity, although not the specificity, of several effects on the sleep-wake cycle. Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.org.

The United Nations Basic Space Science Initiative

NASA Astrophysics Data System (ADS)

Haubold, Hans; Balogh, Werner

2014-05-01

The basic space science initiative was a long-term effort for the development of astronomy and space science through regional and international cooperation in this field on a worldwide basis, particularly in developing nations. Basic space science workshops were co-sponsored and co-organized by ESA, JAXA, and NASA. A series of workshops on basic space science was held from 1991 to 2004 (India 1991, Costa Rica and Colombia 1992, Nigeria 1993, Egypt 1994, Sri Lanka 1995, Germany 1996, Honduras 1997, Jordan 1999, France 2000, Mauritius 2001, Argentina 2002, and China 2004; http://neutrino.aquaphoenix.com/un-esa/) and addressed the status of astronomy in Asia and the Pacific, Latin America and the Caribbean, Africa, and Western Asia. Through the lead of the National Astronomical Observatory Japan, astronomical telescope facilities were inaugurated in seven developing nations and planetariums were established in twenty developing nations based on the donation of respective equipment by Japan.Pursuant to resolutions of the Committee on the Peaceful Uses of Outer Space of the United Nations (COPUOS) and its Scientific and Technical Subcommittee, since 2005, these workshops focused on the preparations for and the follow-ups to the International Heliophysical Year 2007 (UAE 2005, India 2006, Japan 2007, Bulgaria 2008, South Korea 2009; www.unoosa.org/oosa/SAP/bss/ihy2007/index.html). IHY's legacy is the current operation of 16 worldwide instrument arrays with more than 1000 instruments recording data on solar-terrestrial interaction from coronal mass ejections to variations of the total electron content in the ionosphere (http://iswisecretariat.org/). Instruments are provided to hosting institutions by entities of Armenia, Brazil, France, Israel, Japan, Switzerland, and the United States. Starting in 2010, the workshops focused on the International Space Weather Initiative (ISWI) as mandated in a three-year-work plan as part of the deliberations of COPUOS. Workshops on ISWI

Basic Energy Sciences FY 2012 Research Summaries

DOE Office of Scientific and Technical Information (OSTI.GOV)

None

This report provides a collection of research abstracts and highlights for more than 1,400 research projects funded by the Office of Basic Energy Sciences (BES) in Fiscal Year 2012 at some 180 institutions across the U.S. This volume is organized along the three BES Divisions: Materials Sciences and Engineering; Chemical Sciences, Geosciences, and Biosciences; and Scientific User Facilities.

Basic Energy Sciences FY 2014 Research Summaries

DOE Office of Scientific and Technical Information (OSTI.GOV)

None

This report provides a collection of research abstracts and highlights for more than 1,200 research projects funded by the Office of Basic Energy Sciences (BES) in Fiscal Year 2014 at some 200 institutions across the U.S. This volume is organized along the three BES Divisions: Materials Sciences and Engineering; Chemical Sciences, Geosciences, and Biosciences; and Scientific User Facilities.

The New Millennium and an Education That Captures the Basic Spirit of Science.

ERIC Educational Resources Information Center

Bybee, Rodger W.

This document discusses reflections of the old and new millennium on education that capture the basic spirit of science. The explanation includes basic scientific ideas in physical sciences, earth systems, solar system and space; living systems; basic scientific thinking; the basic distinction between science and technology; basic connections…

Radiological Dispersion Devices and Basic Radiation Science

ERIC Educational Resources Information Center

Bevelacqua, Joseph John

2010-01-01

Introductory physics courses present the basic concepts of radioactivity and an overview of nuclear physics that emphasizes the basic decay relationship and the various types of emitted radiation. Although this presentation provides insight into radiological science, it often fails to interest students to explore these concepts in a more rigorous…

The Museum of Science and Industry Basic List of Children's Science Books, 1986.

ERIC Educational Resources Information Center

Richter, Bernice, Comp.; Wenzel, Duane, Comp.

This first supplement to the Museum of Science and Industry Basic List of Children's Science Books contains books received for the museum's 13th annual children's science book fair. Children's science books are listed under these headings: animals; astronomy; aviation and space; biography; careers; earth sciences; environment/conservation;…

Speaking of food: connecting basic and applied plant science.

PubMed

Gross, Briana L; Kellogg, Elizabeth A; Miller, Allison J

2014-10-01

The Food and Agriculture Organization (FAO) predicts that food production must rise 70% over the next 40 years to meet the demands of a growing population that is expected to reach nine billion by the year 2050. Many facets of basic plant science promoted by the Botanical Society of America are important for agriculture; however, more explicit connections are needed to bridge the gap between basic and applied plant research. This special issue, Speaking of Food: Connecting Basic and Applied Plant Science, was conceived to showcase productive overlaps of basic and applied research to address the challenges posed by feeding billions of people and to stimulate more research, fresh connections, and new paradigms. Contributions to this special issue thus illustrate some interactive areas of study in plant science-historical and modern plant-human interaction, crop and weed origins and evolution, and the effects of natural and artificial selection on crops and their wild relatives. These papers provide examples of how research integrating the basic and applied aspects of plant science benefits the pursuit of knowledge and the translation of that knowledge into actions toward sustainable production of crops and conservation of diversity in a changing climate. © 2014 Botanical Society of America, Inc.

75 FR 65363 - Basic Behavioral and Social Science Opportunity Network (OppNet)

Federal Register 2010, 2011, 2012, 2013, 2014

2010-10-22

... public meeting to promote and publicize the Basic Behavioral and Social Science Opportunity Network (Opp... . Background: The Basic Behavioral and Social Science Opportunity Network (OppNet) is a trans-NIH initiative to expand the agency's funding of basic behavioral and social sciences research (b-BSSR). OppNet prioritizes...

The Effect of Home Related Science Activities on Students' Performance in Basic Science

ERIC Educational Resources Information Center

Obomanu, B. J.; Akporehwe, J. N.

2012-01-01

Our study investigated the effect of utilizing home related science activities on student's performance in some basic science concepts. The concepts considered were heart energy, ecology and mixtures. The sample consisted of two hundred and forty (240) basic junior secondary two (BJSS11) students drawn from a population of five thousand and…

Integration of Basic and Clinical Science in the Psychiatry Clerkship.

PubMed

Wilkins, Kirsten M; Moore, David; Rohrbaugh, Robert M; Briscoe, Gregory W

2017-06-01

Integration of basic and clinical science is a key component of medical education reform, yet best practices have not been identified. The authors compared two methods of basic and clinical science integration in the psychiatry clerkship. Two interventions aimed at integrating basic and clinical science were implemented and compared in a dementia conference: flipped curriculum and coteaching by clinician and physician-scientist. The authors surveyed students following each intervention. Likert-scale responses were compared. Participants in both groups responded favorably to the integration format and would recommend integration be implemented elsewhere in the curriculum. Survey response rates differed significantly between the groups and student engagement with the flipped curriculum video was limited. Flipped curriculum and co-teaching by clinician and physician-scientist are two methods of integrating basic and clinical science in the psychiatry clerkship. Student learning preferences may influence engagement with a particular teaching format.

Basic Curriculum Guide--Science. Grades K-6.

ERIC Educational Resources Information Center

Starr, John W., 3rd., Ed.

GRADES OR AGES: K-6. SUBJECT MATTER: Science. ORGANIZATION AND PHYSICAL APPEARANCE: The guide is in two parts--the background, philosophy, and instructional principles of science teaching, including a resource unit model, and the development by grade level of the various basic scientific concepts. The guide also includes information of…

The Museum of Science and Industry Basic List of Children's Science Books, 1987.

ERIC Educational Resources Information Center

Richter, Bernice, Comp.; Wenzel, Duane, Comp.

Presented is the second annual supplement to the Museum of Science and Industry Basic List of Children's Science Books 1973-1984. In this supplement, children's science books are listed under the headings of animals, astronomy, aviation and space, biography, earth sciences, encyclopedias and reference books, environment and conservation, fiction,…

Training of physicians for the twenty-first century: role of the basic sciences.

PubMed

Grande, Joseph P

2009-09-01

Rapid changes in the healthcare environment and public dissatisfaction with the cost and quality of medical care have prompted a critical analysis of how physicians are trained in the United States. Accrediting agencies have catalyzed a transformation from a process based to a competency-based curriculum, both at the undergraduate and the graduate levels. The objective of this overview is to determine how these changes are likely to alter the role of basic science in medical education. Policy statements related to basic science education from the National Board of Medical Examiners (NBME), the Accreditation Council for Graduate Medical Education (ACGME), American Board of Medical Specialties (ABMS), and the Federation of State Medical Boards (FSMB) were reviewed and assessed for common themes. Three primary roles for the basic sciences in medical education are proposed: (1) basic science to support the development of clinical reasoning skills; (2) basic science to support a critical analysis of medical and surgical interventions ("evidence-based medicine"); and (3) basic and translational science to support analysis of processes to improve healthcare ("science of healthcare delivery"). With these roles in mind, several methods to incorporate basic sciences into the curriculum are suggested.

Analysis of the basic science section of the orthopaedic in-training examination.

PubMed

Sheibani-Rad, Shahin; Arnoczky, Steven Paul; Walter, Norman E

2012-08-01

Since 1963, the Orthopaedic In-Training Examination (OITE) has been administered to orthopedic residents to assess residents' knowledge and measure the quality of teaching within individual programs. The OITE currently consists of 275 questions divided among 12 domains. This study analyzed all OITE basic science questions between 2006 and 2010. The following data were recorded: number of questions, question taxonomy, category of question, type of imaging modality, and recommended journal and book references. Between 2006 and 2010, the basic science section constituted 12.2% of the OITE. The assessment of taxonomy classification showed that recall-type questions were the most common, at 81.4%. Imaging modalities typically involved questions on radiographs and constituted 6.2% of the OITE basic science section. The majority of questions were basic science questions (eg, genetics, cell replication, and bone metabolism), with an average of 26.4 questions per year. The Journal of Bone & Joint Surgery (American Volume) and the American Academy of Orthopaedic Surgeons' Orthopaedic Basic Science were the most commonly and consistently cited journal and review book, respectively. This study provides the first review of the question content and recommended references of the OITE basic science section. This information will provide orthopedic trainees, orthopedic residency programs, and the American Academy of Orthopaedic Surgeons Evaluation Committee valuable information related to improving residents' knowledge and performance and optimizing basic science educational curricula. Copyright 2012, SLACK Incorporated.

Radiological Dispersion Devices and Basic Radiation Science

NASA Astrophysics Data System (ADS)

Bevelacqua, Joseph John

2010-05-01

Introductory physics courses present the basic concepts of radioactivity and an overview of nuclear physics that emphasizes the basic decay relationship and the various types of emitted radiation. Although this presentation provides insight into radiological science, it often fails to interest students to explore these concepts in a more rigorous manner. One reason for limited student interest is the failure to link the discussion to topics of current interest. The author has found that presenting this material with a link to radiological dispersion devices (RDDs), or dirty bombs, and their associated health effects provides added motivation for students. The events of Sept. 11, 2001, and periodic media focus on RDDs heighten student interest from both a scientific curiosity as well as a personal protection perspective. This article presents a framework for a more interesting discussion of the basics of radiation science and their associated health effects. The presentation can be integrated with existing radioactivity lectures or added as a supplementary or enrichment activity.

Connecting Science and Society: Basic Research in the Service of Social Objectives

NASA Astrophysics Data System (ADS)

Sonnert, Gerhard

2007-03-01

A flawed dichotomy of basic versus applied science (or of ``curiosity-driven'' vs. ``mission-oriented'' science) pervades today's thinking about science policy. This talk argues for the addition of a third mode of scientific research, called Jeffersonian science. Whereas basic science, as traditionally understood, is a quest for the unknown regardless of societal needs, and applied science is known science applied to known needs, Jeffersonian science is the quest for the unknown in the service of a known social need. It is research in an identified area of basic scientific ignorance that lies at the heart of a social problem. The talk discusses the conceptual foundations and then provides some case examples of Jeffersonian-type science initiatives, such as the Lewis and Clark Expedition, initiated by Thomas Jefferson (which led us to call this mode of research Jeffersonian), research conducted under the auspices of the National Institutes of Health, and a science policy project by President Jimmy Carter and his Science Adviser, Frank Press, in the late 1970s. Because the concept of Jeffersonian science explicitly ties basic research to the social good, one of the potential benefits of adding a Jeffersonian dimension to our thinking about science is that it might make science careers more attractive to women and underrepresented minorities.

FWP executive summaries: basic energy sciences materials sciences and engineering program (SNL/NM).

DOE Office of Scientific and Technical Information (OSTI.GOV)

Samara, George A.; Simmons, Jerry A.

2006-07-01

This report presents an Executive Summary of the various elements of the Materials Sciences and Engineering Program which is funded by the Division of Materials Sciences and Engineering, Office of Basic Energy Sciences, U.S. Department of Energy at Sandia National Laboratories, New Mexico. A general programmatic overview is also presented.

Effects of Aircraft Wake Dynamics on Measured and Simulated NO(x) and HO(x) Wake Chemistry. Appendix B

NASA Technical Reports Server (NTRS)

Lewellen, D. C.; Lewellen, W. S.

2001-01-01

High-resolution numerical large-eddy simulations of the near wake of a B757 including simplified NOx and HOx chemistry were performed to explore the effects of dynamics on chemistry in wakes of ages from a few seconds to several minutes. Dilution plays an important basic role in the NOx-O3 chemistry in the wake, while a more interesting interaction between the chemistry and dynamics occurs for the HOx species. These simulation results are compared with published measurements of OH and HO2 within a B757 wake under cruise conditions in the upper troposphere taken during the Subsonic Aircraft Contrail and Cloud Effects Special Study (SUCCESS) mission in May 1996. The simulation provides a much finer grained representation of the chemistry and dynamics of the early wake than is possible from the 1 s data samples taken in situ. The comparison suggests that the previously reported discrepancy of up to a factor of 20 - 50 between the SUCCESS measurements of the [HO2]/[OH] ratio and that predicted by simplified theoretical computations is due to the combined effects of large mixing rates around the wake plume edges and averaging over volumes containing large species fluctuations. The results demonstrate the feasibility of using three-dimensional unsteady large-eddy simulations with coupled chemistry to study such phenomena.

Opportunities for Computational Discovery in Basic Energy Sciences

NASA Astrophysics Data System (ADS)

Pederson, Mark

2011-03-01

An overview of the broad-ranging support of computational physics and computational science within the Department of Energy Office of Science will be provided. Computation as the third branch of physics is supported by all six offices (Advanced Scientific Computing, Basic Energy, Biological and Environmental, Fusion Energy, High-Energy Physics, and Nuclear Physics). Support focuses on hardware, software and applications. Most opportunities within the fields of~condensed-matter physics, chemical-physics and materials sciences are supported by the Officeof Basic Energy Science (BES) or through partnerships between BES and the Office for Advanced Scientific Computing. Activities include radiation sciences, catalysis, combustion, materials in extreme environments, energy-storage materials, light-harvesting and photovoltaics, solid-state lighting and superconductivity.~ A summary of two recent reports by the computational materials and chemical communities on the role of computation during the next decade will be provided. ~In addition to materials and chemistry challenges specific to energy sciences, issues identified~include a focus on the role of the domain scientist in integrating, expanding and sustaining applications-oriented capabilities on evolving high-performance computing platforms and on the role of computation in accelerating the development of innovative technologies. ~~

Optometry Basic Science Curricula: Current Status.

ERIC Educational Resources Information Center

Berman, Morris S.

1991-01-01

A national survey of optometry schools (n=10) concerning the status of basic biological science instruction provides insight into manpower, curriculum, learning resources, and budgetary support currently available. Results indicate that major changes must occur and that a national effort will be needed to support them. (Author/MSE)

A new methodology for free wake analysis using curved vortex elements

NASA Technical Reports Server (NTRS)

Bliss, Donald B.; Teske, Milton E.; Quackenbush, Todd R.

1987-01-01

A method using curved vortex elements was developed for helicopter rotor free wake calculations. The Basic Curve Vortex Element (BCVE) is derived from the approximate Biot-Savart integration for a parabolic arc filament. When used in conjunction with a scheme to fit the elements along a vortex filament contour, this method has a significant advantage in overall accuracy and efficiency when compared to the traditional straight-line element approach. A theoretical and numerical analysis shows that free wake flows involving close interactions between filaments should utilize curved vortex elements in order to guarantee a consistent level of accuracy. The curved element method was implemented into a forward flight free wake analysis, featuring an adaptive far wake model that utilizes free wake information to extend the vortex filaments beyond the free wake regions. The curved vortex element free wake, coupled with this far wake model, exhibited rapid convergence, even in regions where the free wake and far wake turns are interlaced. Sample calculations are presented for tip vortex motion at various advance ratios for single and multiple blade rotors. Cross-flow plots reveal that the overall downstream wake flow resembles a trailing vortex pair. A preliminary assessment shows that the rotor downwash field is insensitive to element size, even for relatively large curved elements.

Exploring cognitive integration of basic science and its effect on diagnostic reasoning in novices.

PubMed

Lisk, Kristina; Agur, Anne M R; Woods, Nicole N

2016-06-01

Integration of basic and clinical science knowledge is increasingly being recognized as important for practice in the health professions. The concept of 'cognitive integration' places emphasis on the value of basic science in providing critical connections to clinical signs and symptoms while accounting for the fact that clinicians may not spontaneously articulate their use of basic science knowledge in clinical reasoning. In this study we used a diagnostic justification test to explore the impact of integrated basic science instruction on novices' diagnostic reasoning process. Participants were allocated to an integrated basic science or clinical science training group. The integrated basic science group was taught the clinical features along with the underlying causal mechanisms of four musculoskeletal pathologies while the clinical science group was taught only the clinical features. Participants completed a diagnostic accuracy test immediately after initial learning, and one week later a diagnostic accuracy and justification test. The results showed that novices who learned the integrated causal mechanisms had superior diagnostic accuracy and better understanding of the relative importance of key clinical features. These findings further our understanding of cognitive integration by providing evidence of the specific changes in clinical reasoning when basic and clinical sciences are integrated during learning.

A critical narrative review of transfer of basic science knowledge in health professions education.

PubMed

Castillo, Jean-Marie; Park, Yoon Soo; Harris, Ilene; Cheung, Jeffrey J H; Sood, Lonika; Clark, Maureen D; Kulasegaram, Kulamakan; Brydges, Ryan; Norman, Geoffrey; Woods, Nicole

2018-06-01

'Transfer' is the application of a previously learned concept to solve a new problem in another context. Transfer is essential for basic science education because, to be valuable, basic science knowledge must be transferred to clinical problem solving. Therefore, better understanding of interventions that enhance the transfer of basic science knowledge to clinical reasoning is essential. This review systematically identifies interventions described in the health professions education (HPE) literature that document the transfer of basic science knowledge to clinical reasoning, and considers teaching and assessment strategies. A systematic search of the literature was conducted. Articles related to basic science teaching at the undergraduate level in HPE were analysed using a 'transfer out'/'transfer in' conceptual framework. 'Transfer out' refers to the application of knowledge developed in one learning situation to the solving of a new problem. 'Transfer in' refers to the use of previously acquired knowledge to learn from new problems or learning situations. Of 9803 articles initially identified, 627 studies were retrieved for full text evaluation; 15 were included in the literature review. A total of 93% explored 'transfer out' to clinical reasoning and 7% (one article) explored 'transfer in'. Measures of 'transfer out' fostered by basic science knowledge included diagnostic accuracy over time and in new clinical cases. Basic science knowledge supported learning - 'transfer in' - of new related content and ultimately the 'transfer out' to diagnostic reasoning. Successful teaching strategies included the making of connections between basic and clinical sciences, the use of commonsense analogies, and the study of multiple clinical problems in multiple contexts. Performance on recall tests did not reflect the transfer of basic science knowledge to clinical reasoning. Transfer of basic science knowledge to clinical reasoning is an essential component of HPE that

Storytelling in Earth sciences: The eight basic plots

NASA Astrophysics Data System (ADS)

Phillips, Jonathan

2012-11-01

Reporting results and promoting ideas in science in general, and Earth science in particular, is treated here as storytelling. Just as in literature and drama, storytelling in Earth science is characterized by a small number of basic plots. Though the list is not exhaustive, and acknowledging that multiple or hybrid plots and subplots are possible in a single piece, eight standard plots are identified, and examples provided: cause-and-effect, genesis, emergence, destruction, metamorphosis, convergence, divergence, and oscillation. The plots of Earth science stories are not those of literary traditions, nor those of persuasion or moral philosophy, and deserve separate consideration. Earth science plots do not conform those of storytelling more generally, implying that Earth scientists may have fundamentally different motivations than other storytellers, and that the basic plots of Earth Science derive from the characteristics and behaviors of Earth systems. In some cases preference or affinity to different plots results in fundamentally different interpretations and conclusions of the same evidence. In other situations exploration of additional plots could help resolve scientific controversies. Thus explicit acknowledgement of plots can yield direct scientific benefits. Consideration of plots and storytelling devices may also assist in the interpretation of published work, and can help scientists improve their own storytelling.

Information-seeking behavior of basic science researchers: implications for library services.

PubMed

Haines, Laura L; Light, Jeanene; O'Malley, Donna; Delwiche, Frances A

2010-01-01

This study examined the information-seeking behaviors of basic science researchers to inform the development of customized library services. A qualitative study using semi-structured interviews was conducted on a sample of basic science researchers employed at a university medical school. The basic science researchers used a variety of information resources ranging from popular Internet search engines to highly technical databases. They generally relied on basic keyword searching, using the simplest interface of a database or search engine. They were highly collegial, interacting primarily with coworkers in their laboratories and colleagues employed at other institutions. They made little use of traditional library services and instead performed many traditional library functions internally. Although the basic science researchers expressed a positive attitude toward the library, they did not view its resources or services as integral to their work. To maximize their use by researchers, library resources must be accessible via departmental websites. Use of library services may be increased by cultivating relationships with key departmental administrative personnel. Despite their self-sufficiency, subjects expressed a desire for centralized information about ongoing research on campus and shared resources, suggesting a role for the library in creating and managing an institutional repository.

Dynamics of sleep/wake determination--Normal and abnormal

NASA Astrophysics Data System (ADS)

Mahowald, Mark W.; Schenck, Carlos H.; O'Connor, Kevin A.

1991-10-01

Virtually all members of the animal kingdom experience a relentless and powerful cycling of states of being: wakefulness, rapid eye movement sleep, and nonrapid eye movement sleep. Each of these states is composed of a number of physiologic variables generated in a variety of neural structures. The predictable oscillations of these states are driven by presumed neural pacemakers which are entrained to the 24 h geophysical environment by the light/dark cycle. Experiments in nature have indicated that wake/sleep rhythm perturbations may occur either involving desynchronization of the basic 24 h wake/sleep cycle within the geophysical 24 h cycle (circadian rhythm disturbances) or involving the rapid oscillation or incomplete declaration of state (such as narcolepsy). The use of phase spaces to describe states of being may be of interest in the description of state determination in both illness and health. Some fascinating clinical and experimental phenomena may represent bifurcations in the sleep/wake control system.

Making evolutionary biology a basic science for medicine

PubMed Central

Nesse, Randolph M.; Bergstrom, Carl T.; Ellison, Peter T.; Flier, Jeffrey S.; Gluckman, Peter; Govindaraju, Diddahally R.; Niethammer, Dietrich; Omenn, Gilbert S.; Perlman, Robert L.; Schwartz, Mark D.; Thomas, Mark G.; Stearns, Stephen C.; Valle, David

2010-01-01

New applications of evolutionary biology in medicine are being discovered at an accelerating rate, but few physicians have sufficient educational background to use them fully. This article summarizes suggestions from several groups that have considered how evolutionary biology can be useful in medicine, what physicians should learn about it, and when and how they should learn it. Our general conclusion is that evolutionary biology is a crucial basic science for medicine. In addition to looking at established evolutionary methods and topics, such as population genetics and pathogen evolution, we highlight questions about why natural selection leaves bodies vulnerable to disease. Knowledge about evolution provides physicians with an integrative framework that links otherwise disparate bits of knowledge. It replaces the prevalent view of bodies as machines with a biological view of bodies shaped by evolutionary processes. Like other basic sciences, evolutionary biology needs to be taught both before and during medical school. Most introductory biology courses are insufficient to establish competency in evolutionary biology. Premedical students need evolution courses, possibly ones that emphasize medically relevant aspects. In medical school, evolutionary biology should be taught as one of the basic medical sciences. This will require a course that reviews basic principles and specific medical applications, followed by an integrated presentation of evolutionary aspects that apply to each disease and organ system. Evolutionary biology is not just another topic vying for inclusion in the curriculum; it is an essential foundation for a biological understanding of health and disease. PMID:19918069

First Lunar Wake Passage of ARTEMIS: Discrimination of Wake Effects and Solar Wind Fluctuations by 3D Hybrid Simulations

NASA Technical Reports Server (NTRS)

Wiehle, S.; Plaschke, F.; Motschmann, U.; Glassmeier, K. H.; Auster, H. U.; Angelopoulos, V.; Mueller, J.; Kriegel, H.; Georgescu, E.; Halekas, J.;

Wake County Public School System Design Guidelines.

ERIC Educational Resources Information Center

Wake County Public School System, Raleigh, NC.

The Wake County Public School System has published its guidelines for planning and design of functional, cost effective, and durable educational facilities that are attractive and enhance the students' educational experience. The guidelines present basic planning requirement and design criteria for the entire construction process, including: codes…

Integration of Basic and Clinical Sciences: Faculty Perspectives at a U.S. Dental School.

PubMed

van der Hoeven, Dharini; van der Hoeven, Ransome; Zhu, Liang; Busaidy, Kamal; Quock, Ryan L

2018-04-01

Although dental education has traditionally been organized into basic sciences education (first and second years) and clinical education (third and fourth years), there has been growing interest in ways to better integrate the two to more effectively educate students and prepare them for practice. Since 2012, The University of Texas School of Dentistry at Houston (UTSD) has made it a priority to improve integration of basic and clinical sciences, with a focus to this point on integrating the basic sciences. The aim of this study was to determine the perspectives of basic and clinical science faculty members regarding basic and clinical sciences integration and the degree of integration currently occurring. In October 2016, all 227 faculty members (15 basic scientists and 212 clinicians) were invited to participate in an online survey. Of the 212 clinicians, 84 completed the clinician educator survey (response rate 40%). All 15 basic scientists completed the basic science educator survey (response rate 100%). The majority of basic and clinical respondents affirmed the value of integration (93.3%, 97.6%, respectively) and reported regular integration in their teaching (80%, 86.9%). There were no significant differences between basic scientists and clinicians on perceived importance (p=0.457) and comfort with integration (p=0.240), but the basic scientists were more likely to integrate (p=0.039) and collaborate (p=0.021) than the clinicians. There were no significant differences between generalist and specialist clinicians on importance (p=0.474) and degree (p=0.972) of integration in teaching and intent to collaborate (p=0.864), but the specialists reported feeling more comfortable presenting basic science information (p=0.033). Protected faculty time for collaborative efforts and a repository of integrated basic science and clinical examples for use in teaching and faculty development were recommended to improve integration. Although questions might be raised about

Progress in the Utilization of High-Fidelity Simulation in Basic Science Education

ERIC Educational Resources Information Center

Helyer, Richard; Dickens, Peter

2016-01-01

High-fidelity patient simulators are mainly used to teach clinical skills and remain underutilized in teaching basic sciences. This article summarizes our current views on the use of simulation in basic science education and identifies pitfalls and opportunities for progress.

Alternative Methods by Which Basic Science Pharmacy Faculty Can Relate to Clinical Practice.

ERIC Educational Resources Information Center

Kabat, Hugh F.; And Others

1982-01-01

A panel of pharmacy faculty ranked a broad inventory of basic pharmaceutical science topics in terms of their applicability to clinical pharmacy practice. The panel concluded that basic pharmaceutical sciences are essentially applications of foundation areas in biological, physical, and social sciences. (Author/MLW)

Information-seeking behavior of basic science researchers: implications for library services

PubMed Central

Haines, Laura L.; Light, Jeanene; O'Malley, Donna; Delwiche, Frances A.

2010-01-01

Objectives: This study examined the information-seeking behaviors of basic science researchers to inform the development of customized library services. Methods: A qualitative study using semi-structured interviews was conducted on a sample of basic science researchers employed at a university medical school. Results: The basic science researchers used a variety of information resources ranging from popular Internet search engines to highly technical databases. They generally relied on basic keyword searching, using the simplest interface of a database or search engine. They were highly collegial, interacting primarily with coworkers in their laboratories and colleagues employed at other institutions. They made little use of traditional library services and instead performed many traditional library functions internally. Conclusions: Although the basic science researchers expressed a positive attitude toward the library, they did not view its resources or services as integral to their work. To maximize their use by researchers, library resources must be accessible via departmental websites. Use of library services may be increased by cultivating relationships with key departmental administrative personnel. Despite their self-sufficiency, subjects expressed a desire for centralized information about ongoing research on campus and shared resources, suggesting a role for the library in creating and managing an institutional repository. PMID:20098658

Preparing medical students for future learning using basic science instruction.

PubMed

Mylopoulos, Maria; Woods, Nicole

2014-07-01

The construct of 'preparation for future learning' (PFL) is understood as the ability to learn new information from available resources, relate new learning to past experiences and demonstrate innovation and flexibility in problem solving. Preparation for future learning has been proposed as a key competence of adaptive expertise. There is a need for educators to ensure that opportunities are provided for students to develop PFL ability and that assessments accurately measure the development of this form of competence. The objective of this research was to compare the relative impacts of basic science instruction and clinically focused instruction on performance on a PFL assessment (PFLA). This study employed a 'double transfer' design. Fifty-one pre-clerkship students were randomly assigned to either basic science instruction or clinically focused instruction to learn four categories of disease. After completing an initial assessment on the learned material, all participants received clinically focused instruction for four novel diseases and completed a PFLA. The data from the initial assessment and the PFLA were submitted to independent-sample t-tests. Mean ± standard deviation [SD] scores on the diagnostic cases in the initial assessment were similar for participants in the basic science (0.65 ± 0.11) and clinical learning (0.62 ± 0.11) conditions. The difference was not significant (t[42] = 0.90, p = 0.37, d = 0.27). Analysis of the diagnostic cases on the PFLA revealed significantly higher mean ± SD scores for participants in the basic science learning condition (0.72 ± 0.14) compared with those in the clinical learning condition (0.63 ± 0.15) (t[42] = 2.02, p = 0.05, d = 0.62). Our results show that the inclusion of basic science instruction enhanced the learning of novel related content. We discuss this finding within the broader context of research on basic science instruction, development of adaptive expertise and assessment

Japanese medical students' interest in basic sciences: a questionnaire survey of a medical school in Japan.

PubMed

Yamazaki, Yuka; Uka, Takanori; Shimizu, Haruhiko; Miyahira, Akira; Sakai, Tatsuo; Marui, Eiji

2013-02-01

The number of physicians engaged in basic sciences and teaching is sharply decreasing in Japan. To alleviate this shortage, central government has increased the quota of medical students entering the field. This study investigated medical students' interest in basic sciences in efforts to recruit talent. A questionnaire distributed to 501 medical students in years 2 to 6 of Juntendo University School of Medicine inquired about sex, grade, interest in basic sciences, interest in research, career path as a basic science physician, faculties' efforts to encourage students to conduct research, increases in the number of lectures, and practical training sessions on research. Associations between interest in basic sciences and other variables were examined using χ(2) tests. From among the 269 medical students (171 female) who returned the questionnaire (response rate 53.7%), 24.5% of respondents were interested in basic sciences and half of them considered basic sciences as their future career. Obstacles to this career were their original aim to become a clinician and concerns about salary. Medical students who were likely to be interested in basic sciences were fifth- and sixth-year students, were interested in research, considered basic sciences as their future career, considered faculties were making efforts to encourage medical students to conduct research, and wanted more research-related lectures. Improving physicians' salaries in basic sciences is important for securing talent. Moreover, offering continuous opportunities for medical students to experience research and encouraging advanced-year students during and after bedside learning to engage in basic sciences are important for recruiting talent.

Basic science research in urology training.

PubMed

Eberli, D; Atala, A

2009-04-01

The role of basic science exposure during urology training is a timely topic that is relevant to urologic health and to the training of new physician scientists. Today, researchers are needed for the advancement of this specialty, and involvement in basic research will foster understanding of basic scientific concepts and the development of critical thinking skills, which will, in turn, improve clinical performance. If research education is not included in urology training, future urologists may not be as likely to contribute to scientific discoveries.Currently, only a minority of urologists in training are currently exposed to significant research experience. In addition, the number of physician-scientists in urology has been decreasing over the last two decades, as fewer physicians are willing to undertake a career in academics and perform basic research. However, to ensure that the field of urology is driving forward and bringing novel techniques to patients, it is clear that more research-trained urologists are needed. In this article we will analyse the current status of basic research in urology training and discuss the importance of and obstacles to successful addition of research into the medical training curricula. Further, we will highlight different opportunities for trainees to obtain significant research exposure in urology.

A brief simulation intervention increasing basic science and clinical knowledge.

PubMed

Sheakley, Maria L; Gilbert, Gregory E; Leighton, Kim; Hall, Maureen; Callender, Diana; Pederson, David

2016-01-01

The United States Medical Licensing Examination (USMLE) is increasing clinical content on the Step 1 exam; thus, inclusion of clinical applications within the basic science curriculum is crucial. Including simulation activities during basic science years bridges the knowledge gap between basic science content and clinical application. To evaluate the effects of a one-off, 1-hour cardiovascular simulation intervention on a summative assessment after adjusting for relevant demographic and academic predictors. This study was a non-randomized study using historical controls to evaluate curricular change. The control group received lecture (n l=515) and the intervention group received lecture plus a simulation exercise (n l+s=1,066). Assessment included summative exam questions (n=4) that were scored as pass/fail (≥75%). USMLE-style assessment questions were identical for both cohorts. Descriptive statistics for variables are presented and odds of passage calculated using logistic regression. Undergraduate grade point ratio, MCAT-BS, MCAT-PS, age, attendance at an academic review program, and gender were significant predictors of summative exam passage. Students receiving the intervention were significantly more likely to pass the summative exam than students receiving lecture only (P=0.0003). Simulation plus lecture increases short-term understanding as tested by a written exam. A longitudinal study is needed to assess the effect of a brief simulation intervention on long-term retention of clinical concepts in a basic science curriculum.

The Reorganization of Basic Science Departments in U.S. Medical Schools, 1980-1999.

ERIC Educational Resources Information Center

Mallon, William T.; Biebuyck, Julien F.; Jones, Robert F.

2003-01-01

Constructed a longitudinal database to examine how basic science departments have been reorganized at U.S. medical schools. Found that there were fewer basic science departments in the traditional disciplines of anatomy, biochemistry, microbiology, pharmacology, and physiology in 1999 than in 1980. But as biomedical science has developed in an…

United Nations/European Space Agency Workshops on Basic Space Science

NASA Technical Reports Server (NTRS)

Haubold, H. J.; Ocampo, A.; Torres, S.; Wamsteker, W.

1995-01-01

In 1958, the United Nations (UN) formally recognized a new potential for international cooperation by establishing an ad hoc Committee on the Peaceful Uses of Outer Space (COPUOS). A year later the Committee became a permanent body, and by 1983 membership had expanded to 53 states, with more than half of the members coming from the developing world. In 1970, COPUOS established the UN Program on Space Applications in order to strengthen cooperation in space science and technology between non-industrialized and industrialized countries. In the last few years, the UN and its COPUOS have paid increasing attention to education and research in space science and technology, including basic space science. In 1991 the UN, in cooperation with ESA, initiated the organization of annual Workshops in Basic Space Science for developing countries. These Workshops are designed to be held in one of the following major regions: Asia and the Pacific, Latin America and the Caribbean, Africa, Western Asia, and Europe. Accordingly, Basic Space Science Workshops have already been held in India (1991), Costa Rica andColombia (1992), and Nigeria (1993). The fourth Workshop was held from 27 June to 1 July 1994 at the Cairo University, in Egypt, for Western Asia.

Waking-up to Science!

NASA Astrophysics Data System (ADS)

2007-03-01

The Science on Stage festival as an alarm clock for science teaching How is Europe to tackle its shortage of scientists? The EIROforum Science on Stage festival aims to give European teachers some of the answers they need to take up this urgent challenge. This unique event, showcasing the very best of today's science education, will feature science demonstrations, a science teaching fair with some 66 stands, and a Round Table discussion with the participation of the European Commissioner for Science and Research, Janez Potočnik. ESO PR Photo 14/07 ESO PR Photo 14/07 Science on Stage will have the city of Grenoble (France) buzzing from 2 to 6 April 2007. A rugby team and a hockey team will take on the power of the vacuum, a cook will demonstrate how science can inspire new culinary ideas, visitors will discover the real colour of the sun, an inflatable model of Borromini's gallery will help to explain the science of optical illusions, and Merlin himself will reveal all about how to make a cake float. These are just some of the exciting things that will be happening at the EIROforum Science on Stage festival. By showing how fascinating and entertaining science can be, the event aims to attract young people to science and ultimately help to reduce the shortage of scientists in Europe. With support from the European Commission, this international festival will bring together some 500 science educators from 27 European countries. The highlight of the festival will be a Round Table discussion on 'Science Education in the Age of the Knowledge Society - Strengthening Science Education in Europe', which will take place on 5 April 2007 with the participation of the European Commissioner for Science and Research, Janez Potočnik. The panellists - all high-ranking decision-makers - will include the Danish Minister for Education, Bertel Haarder, the MEP Vittorio Prodi, and the Chair of the UK's Engineering and Physical Sciences Research Council, Julia Higgins. "Curiosity is in

Preliminary rotor wake measurements with a laser velocimeter

NASA Technical Reports Server (NTRS)

Hoad, D. R.; Rhodes, D. B.; Meyers, J. F.

1983-01-01

A laser velocimeter (LV) was used to determine rotor wake characteristics. The effect of various fuselage widths and rotor-fuselage spacings on time averaged and detailed time dependent rotor wake velocity characteristics was defined. Definition of time dependent velocity characteristics was attempted with the LV by associating a rotor azimuth position with each velocity measurement. Results were discouraging in that no apparent time dependent velocity characteristics could be discerned from the LV measurements. Since the LV is a relatively new instrument in the rotor wake measurement field, the cause of this lack of periodicity is as important as the basic research objectives. An attempt was made to identify the problem by simulated acquisition of LV-type data for a predicted rotor wake velocity time history. Power spectral density and autocorrelation function estimation techniques were used to substantiate the conclusion that the primary cause of the lack of time dependent velocity characteristics was the nonstationary flow condition generated by the periodic turbulence level that currently exists in the open throat configuration of the wind tunnel.

A Simulation for Teaching the Basic and Clinical Science of Fluid Therapy

ERIC Educational Resources Information Center

Rawson, Richard E.; Dispensa, Marilyn E.; Goldstein, Richard E.; Nicholson, Kimberley W.; Vidal, Noni Korf

2009-01-01

The course "Management of Fluid and Electrolyte Disorders" is an applied physiology course taught using lectures and paper-based cases. The course approaches fluid therapy from both basic science and clinical perspectives. While paper cases provide a basis for application of basic science concepts, they lack key components of genuine clinical…

Editorial Commentary: A Model for Shoulder Rotator Cuff Repair and for Basic Science Investigations.

PubMed

Brand, Jefferson C

2018-04-01

"Breaking the fourth wall" is a theater convention where the narrator or character speaks directly to the audience. As an Assistant Editor-in-Chief, as I comment on a recent basic science study investigating rotator cuff repair, I break the fourth wall and articulate areas of basic science research excellence that align with the vision that we hold for our journal. Inclusion of a powerful video strengthens the submission. We prefer to publish clinical videos in our companion journal, Arthroscopy Techniques, and encourage basic science video submissions to Arthroscopy. Basic science research requires step-by-tedious-step analogous to climbing a mountain. Establishment of a murine rotator cuff repair model was rigorous and research intensive, biomechanically, radiographically, histologically, and genetically documented, a huge step toward the bone-to-tendon healing research summit. This research results in a model for both rotator cuff repair and the pinnacle of quality, basic science research. Copyright © 2018 Arthroscopy Association of North America. Published by Elsevier Inc. All rights reserved.

Fundamentals of neurogastroenterology: basic science.

PubMed

Grundy, David; Al-Chaer, Elie D; Aziz, Qasim; Collins, Stephen M; Ke, Meiyun; Taché, Yvette; Wood, Jackie D

2006-04-01

The focus of neurogastroenterology in Rome II was the enteric nervous system (ENS). To avoid duplication with Rome II, only advances in ENS neurobiology after Rome II are reviewed together with stronger emphasis on interactions of the brain, spinal cord, and the gut in terms of relevance for abdominal pain and disordered gastrointestinal function. A committee with expertise in selective aspects of neurogastroenterology was invited to evaluate the literature and provide a consensus overview of the Fundamentals of Neurogastroenterology textbook as they relate to functional gastrointestinal disorders (FGIDs). This review is an abbreviated version of a fuller account that appears in the forthcoming book, Rome III. This report reviews current basic science understanding of visceral sensation and its modulation by inflammation and stress and advances in the neurophysiology of the ENS. Many of the concepts are derived from animal studies in which the physiologic mechanisms underlying visceral sensitivity and neural control of motility, secretion, and blood flow are examined. Impact of inflammation and stress in experimental models relative to FGIDs is reviewed as is human brain imaging, which provides a means for translating basic science to understanding FGID symptoms. Investigative evidence and emerging concepts implicate dysfunction in the nervous system as a significant factor underlying patient symptoms in FGIDs. Continued focus on neurogastroenterologic factors that underlie the development of symptoms will lead to mechanistic understanding that is expected to directly benefit the large contingent of patients and care-givers who deal with FGIDs.

A brief simulation intervention increasing basic science and clinical knowledge.

PubMed

Sheakley, Maria L; Gilbert, Gregory E; Leighton, Kim; Hall, Maureen; Callender, Diana; Pederson, David

2016-01-01

Background The United States Medical Licensing Examination (USMLE) is increasing clinical content on the Step 1 exam; thus, inclusion of clinical applications within the basic science curriculum is crucial. Including simulation activities during basic science years bridges the knowledge gap between basic science content and clinical application. Purpose To evaluate the effects of a one-off, 1-hour cardiovascular simulation intervention on a summative assessment after adjusting for relevant demographic and academic predictors. Methods This study was a non-randomized study using historical controls to evaluate curricular change. The control group received lecture (n l =515) and the intervention group received lecture plus a simulation exercise (n l+s =1,066). Assessment included summative exam questions (n=4) that were scored as pass/fail (≥75%). USMLE-style assessment questions were identical for both cohorts. Descriptive statistics for variables are presented and odds of passage calculated using logistic regression. Results Undergraduate grade point ratio, MCAT-BS, MCAT-PS, age, attendance at an academic review program, and gender were significant predictors of summative exam passage. Students receiving the intervention were significantly more likely to pass the summative exam than students receiving lecture only (P=0.0003). Discussion Simulation plus lecture increases short-term understanding as tested by a written exam. A longitudinal study is needed to assess the effect of a brief simulation intervention on long-term retention of clinical concepts in a basic science curriculum.

Integration of Basic Sciences in Health's Courses

ERIC Educational Resources Information Center

Azzalis, L. A.; Giavarotti, L.; Sato, S. N.; Barros, N. M. T.; Junqueira, V. B. C.; Fonseca, F. L. A.

2012-01-01

Concepts from disciplines such as Biochemistry, Genetics, Cellular and Molecular Biology are essential to the understanding and treatment of an elevated number of illnesses, but often they are studied separately, with no integration between them. This article proposes a model for basic sciences integration based on problem-based learning (PBL) and…

Teaching Toxicology as a Basic Medical Science

ERIC Educational Resources Information Center

Gralla, Edward J.

1976-01-01

A 4-year effort at Yale University School of Medicine to teach toxicology as an elective basic science from the standpoint of organ-specific toxic effects is described. The objective of the successful multidisciplinary program is to prepare physicians to understand, recognize, and manage adverse effects from drugs and other environmental…

Wake Vortex Advisory System (WakeVAS) Concept of Operations

NASA Technical Reports Server (NTRS)

Rutishauser, David; Lohr, Gary; Hamilton, David; Powers, Robert; McKissick, Burnell; Adams, Catherine; Norris, Edward

2003-01-01

NASA Langley Research Center has a long history of aircraft wake vortex research, with the most recent accomplishment of demonstrating the Aircraft VOrtex Spacing System (AVOSS) at Dallas/Forth Worth International Airport in July 2000. The AVOSS was a concept for an integration of technologies applied to providing dynamic wake-safe reduced spacing for single runway arrivals, as compared to current separation standards applied during instrument approaches. AVOSS included state-of-the-art weather sensors, wake sensors, and a wake behavior prediction algorithm. Using real-time data AVOSS averaged a 6% potential throughput increase over current standards. This report describes a Concept of Operations for applying the technologies demonstrated in the AVOSS to a variety of terminal operations to mitigate wake vortex capacity constraints. A discussion of the technological issues and open research questions that must be addressed to design a Wake Vortex Advisory System (WakeVAS) is included.

Basic Pharmaceutical Sciences Examination as a Predictor of Student Performance during Clinical Training.

ERIC Educational Resources Information Center

Fassett, William E.; Campbell, William H.

1984-01-01

A comparison of Basic Pharmaceutical Sciences Examination (BPSE) results with student performance evaluations in core clerkships, institutional and community externships, didactic and clinical courses, and related basic science coursework revealed the BPSE does not predict student performance during clinical instruction. (MSE)

Physician perceptions of the role and value of basic science knowledge in daily clinical practice.

PubMed

Fischer, Jennifer A; Muller-Weeks, Susan

2012-01-01

The role of basic science education in a clinical setting remains unclear. Research to understand how academic clinicians perceive and use this part of their education can aid curricular development. To assess physician's attitudes toward the value of science knowledge in their clinical practice. Academic physicians from three medical schools completed a questionnaire about the utility of basic science education in core clinical tasks and in practice-based learning and improvement. A total of 109 clinical faculty returned the survey. Overall, 89% of the respondents indicated that basic science education is valuable to their clinical practice. When asked about the utility of basic science information in relation to direct patient care, greater than 50% of the doctors felt they use this when diagnosing and communicating with patients. This rose to greater than 60% when asked about choosing treatment options for their patients. Individuals also responded that basic science knowledge is valuable when developing evidence-based best practices. Specifically, 89% felt that they draw upon this information when training students/residents and 84% use this information when reading journal articles. This study shows that basic science education is perceived by responding academic physicians to be important to their clinical work.

Comparison of Basic Science Knowledge Between DO and MD Students.

PubMed

Davis, Glenn E; Gayer, Gregory G

2017-02-01

With the coming single accreditation system for graduate medical education, medical educators may wonder whether knowledge in basic sciences is equivalent for osteopathic and allopathic medical students. To examine whether medical students' basic science knowledge is the same among osteopathic and allopathic medical students. A dataset of the Touro University College of Osteopathic Medicine-CA student records from the classes of 2013, 2014, and 2015 and the national cohort of National Board of Medical Examiners Comprehensive Basic Science Examination (NBME-CBSE) parameters for MD students were used. Models of the Comprehensive Osteopathic Medical Licensing Examination-USA (COMLEX-USA) Level 1 scores were fit using linear and logistic regression. The models included variables used in both osteopathic and allopathic medical professions to predict COMLEX-USA outcomes, such as Medical College Admission Test biology scores, preclinical grade point average, number of undergraduate science units, and scores on the NBME-CBSE. Regression statistics were studied to compare the effectiveness of models that included or excluded NBME-CBSE scores at predicting COMLEX-USA Level 1 scores. Variance inflation factor was used to investigate multicollinearity. Receiver operating characteristic curves were used to show the effectiveness of NBME-CBSE scores at predicting COMLEX-USA Level 1 pass/fail outcomes. A t test at 99% level was used to compare mean NBME-CBSE scores with the national cohort. A total of 390 student records were analyzed. Scores on the NBME-CBSE were found to be an effective predictor of COMLEX-USA Level 1 scores (P<.001). The pass/fail outcome on COMLEX-USA Level 1 was also well predicted by NBME-CBSE scores (P<.001). No significant difference was found in performance on the NBME-CBSE between osteopathic and allopathic medical students (P=.322). As an examination constructed to assess the basic science knowledge of allopathic medical students, the NBME-CBSE is

Cognition before curriculum: rethinking the integration of basic science and clinical learning.

PubMed

Kulasegaram, Kulamakan Mahan; Martimianakis, Maria Athina; Mylopoulos, Maria; Whitehead, Cynthia R; Woods, Nicole N

2013-10-01

Integrating basic science and clinical concepts in the undergraduate medical curriculum is an important challenge for medical education. The health professions education literature includes a variety of educational strategies for integrating basic science and clinical concepts at multiple levels of the curriculum. To date, assessment of this literature has been limited. In this critical narrative review, the authors analyzed literature published in the last 30 years (1982-2012) using a previously published integration framework. They included studies that documented approaches to integration at the level of programs, courses, or teaching sessions and that aimed to improve learning outcomes. The authors evaluated these studies for evidence of successful integration and to identify factors that contribute to integration. Several strategies at the program and course level are well described but poorly evaluated. Multiple factors contribute to successful learning, so identifying how interventions at these levels result in successful integration is difficult. Evidence from session-level interventions and experimental studies suggests that integration can be achieved if learning interventions attempt to link basic and clinical science in a causal relationship. These interventions attend to how learners connect different domains of knowledge and suggest that successful integration requires learners to build cognitive associations between basic and clinical science. One way of understanding the integration of basic and clinical science is as a cognitive activity occurring within learners. This perspective suggests that learner-centered, content-focused, and session-level-oriented strategies can achieve cognitive integration.

The United Nations Basic Space Science Initiative

NASA Astrophysics Data System (ADS)

Haubold, H. J.

2006-08-01

Pursuant to recommendations of the United Nations Conference on the Exploration and Peaceful Uses of Outer Space (UNISPACE III) and deliberations of the United Nations Committee on the Peaceful Uses of Outer Space (UNCOPUOS), annual UN/ European Space Agency workshops on basic space science have been held around the world since 1991. These workshops contribute to the development of astrophysics and space science, particularly in developing nations. Following a process of prioritization, the workshops identified the following elements as particularly important for international cooperation in the field: (i) operation of astronomical telescope facilities implementing TRIPOD, (ii) virtual observatories, (iii) astrophysical data systems, (iv) concurrent design capabilities for the development of international space missions, and (v) theoretical astrophysics such as applications of nonextensive statistical mechanics. Beginning in 2005, the workshops focus on preparations for the International Heliophysical Year 2007 (IHY2007). The workshops continue to facilitate the establishment of astronomical telescope facilities as pursued by Japan and the development of low-cost, ground-based, world-wide instrument arrays as lead by the IHY secretariat. Wamsteker, W., Albrecht, R. and Haubold, H.J.: Developing Basic Space Science World-Wide: A Decade of UN/ESA Workshops. Kluwer Academic Publishers, Dordrecht 2004. http://ihy2007.org http://www.unoosa.org/oosa/en/SAP/bss/ihy2007/index.html http://www.cbpf.br/GrupPesq/StatisticalPhys/biblio.htm

The United Nations Basic Space Science Initiative

NASA Astrophysics Data System (ADS)

Haubold, H. J.

Pursuant to recommendations of the United Nations Conference on the Exploration and Peaceful Uses of Outer Space UNISPACE III and deliberations of the United Nations Committee on the Peaceful Uses of Outer Space UNCOPUOS annual UN European Space Agency workshops on basic space science have been held around the world since 1991 These workshops contribute to the development of astrophysics and space science particularly in developing nations Following a process of prioritization the workshops identified the following elements as particularly important for international cooperation in the field i operation of astronomical telescope facilities implementing TRIPOD ii virtual observatories iii astrophysical data systems iv concurrent design capabilities for the development of international space missions and v theoretical astrophysics such as applications of nonextensive statistical mechanics Beginning in 2005 the workshops focus on preparations for the International Heliophysical Year 2007 IHY2007 The workshops continue to facilitate the establishment of astronomical telescope facilities as pursued by Japan and the development of low-cost ground-based world-wide instrument arrays as lead by the IHY secretariat Further information Wamsteker W Albrecht R and Haubold H J Developing Basic Space Science World-Wide A Decade of UN ESA Workshops Kluwer Academic Publishers Dordrecht 2004 http ihy2007 org http www oosa unvienna org SAP bss ihy2007 index html http www cbpf br GrupPesq StatisticalPhys biblio htm

Teaching Basic Probability in Undergraduate Statistics or Management Science Courses

ERIC Educational Resources Information Center

Naidu, Jaideep T.; Sanford, John F.

2017-01-01

Standard textbooks in core Statistics and Management Science classes present various examples to introduce basic probability concepts to undergraduate business students. These include tossing of a coin, throwing a die, and examples of that nature. While these are good examples to introduce basic probability, we use improvised versions of Russian…

Wakes behind surface-mounted obstacles: Impact of aspect ratio, incident angle, and surface roughness

NASA Astrophysics Data System (ADS)

Tobin, Nicolas; Chamorro, Leonardo P.

2018-03-01

The so-called wake-moment coefficient C˜h and lateral wake deflection of three-dimensional windbreaks are explored in the near and far wake. Wind-tunnel experiments were performed to study the functional dependence of C˜h with windbreak aspect ratio, incidence angle, and the ratio of the windbreak height and surface roughness (h /z0 ). Supported with the data, we also propose basic models for the wake deflection of the windbreak in the near and far fields. The near-wake model is based on momentum conservation considering the drag on the windbreak, whereas the far-wake counterpart is based on existing models for wakes behind surface-mounted obstacles. Results show that C˜h does not change with windbreak aspect ratios of 10 or greater; however, it may be lower for an aspect ratio of 5. C˜h is found to change roughly with the cosine of the incidence angle, and to depend strongly on h /z0 . The data broadly support the proposed wake-deflection models, though better predictions could be made with improved knowledge of the windbreak drag coefficient.

Contrail Formation in Aircraft Wakes Using Large-Eddy Simulations

NASA Technical Reports Server (NTRS)

Paoli, R.; Helie, J.; Poinsot, T. J.; Ghosal, S.

2002-01-01

In this work we analyze the issue of the formation of condensation trails ("contrails") in the near-field of an aircraft wake. The basic configuration consists in an exhaust engine jet interacting with a wing-tip training vortex. The procedure adopted relies on a mixed Eulerian/Lagrangian two-phase flow approach; a simple micro-physics model for ice growth has been used to couple ice and vapor phases. Large eddy simulations have carried out at a realistic flight Reynolds number to evaluate the effects of turbulent mixing and wake vortex dynamics on ice-growth characteristics and vapor thermodynamic properties.

Cause and Effect: Testing a Mechanism and Method for the Cognitive Integration of Basic Science.

PubMed

Kulasegaram, Kulamakan; Manzone, Julian C; Ku, Cheryl; Skye, Aimee; Wadey, Veronica; Woods, Nicole N

2015-11-01

Methods of integrating basic science with clinical knowledge are still debated in medical training. One possibility is increasing the spatial and temporal proximity of clinical content to basic science. An alternative model argues that teaching must purposefully expose relationships between the domains. The authors compared different methods of integrating basic science: causal explanations linking basic science to clinical features, presenting both domains separately but in proximity, and simply presenting clinical features First-year undergraduate health professions students were randomized to four conditions: (1) science-causal explanations (SC), (2) basic science before clinical concepts (BC), (3) clinical concepts before basic science (CB), and (4) clinical features list only (FL). Based on assigned conditions, participants were given explanations for four disorders in neurology or rheumatology followed by a memory quiz and diagnostic test consisting of 12 cases which were repeated after one week. Ninety-four participants completed the study. No difference was found on memory test performance, but on the diagnostic test, a condition by time interaction was found (F[3,88] = 3.05, P < .03, ηp = 0.10). Although all groups had similar immediate performance, the SC group had a minimal decrease in performance on delayed testing; the CB and FL groups had the greatest decreases. These results suggest that creating proximity between basic science and clinical concepts may not guarantee cognitive integration. Although cause-and-effect explanations may not be possible for all domains, making explicit and specific connections between domains will likely facilitate the benefits of integration for learners.

The Future of Basic Science in Academic Surgery

PubMed Central

Keswani, Sundeep G.; Moles, Chad M.; Morowitz, Michael; Zeh, Herbert; Kuo, John S.; Levine, Matthew H.; Cheng, Lily S.; Hackam, David J.; Ahuja, Nita; Goldstein, Allan M.

2017-01-01

Objective The aim of this study was to examine the challenges confronting surgeons performing basic science research in today’s academic surgery environment. Summary of Background Data Multiple studies have identified challenges confronting surgeon-scientists and impacting their ability to be successful. Although these threats have been known for decades, the downward trend in the number of successful surgeon-scientists continues. Clinical demands, funding challenges, and other factors play important roles, but a rigorous analysis of academic surgeons and their experiences regarding these issues has not previously been performed. Methods An online survey was distributed to 2504 members of the Association for Academic Surgery and Society of University Surgeons to determine factors impacting success. Survey results were subjected to statistical analyses. We also reviewed publicly available data regarding funding from the National Institutes of Health (NIH). Results NIH data revealed a 27% decline in the proportion of NIH funding to surgical departments relative to total NIH funding from 2007 to 2014. A total of 1033 (41%) members responded to our survey, making this the largest survey of academic surgeons to date. Surgeons most often cited the following factors as major impediments to pursuing basic investigation: pressure to be clinically productive, excessive administrative responsibilities, difficulty obtaining extramural funding, and desire for work-life balance. Surprisingly, a majority (68%) did not believe surgeons can be successful basic scientists in today’s environment, including departmental leadership. Conclusions We have identified important barriers that confront academic surgeons pursuing basic research and a perception that success in basic science may no longer be achievable. These barriers need to be addressed to ensure the continued development of future surgeon-scientists. PMID:27643928

Welding As Science: Applying Basic Engineering Principles to the Discipline

NASA Technical Reports Server (NTRS)

Nunes, A. C., Jr.

2010-01-01

This Technical Memorandum provides sample problems illustrating ways in which basic engineering science has been applied to the discipline of welding. Perhaps inferences may be drawn regarding optimal approaches to particular welding problems, as well as for the optimal education for welding engineers. Perhaps also some readers may be attracted to the science(s) of welding and may make worthwhile contributions to the discipline.

Contexts, concepts and cognition: principles for the transfer of basic science knowledge.

PubMed

Kulasegaram, Kulamakan M; Chaudhary, Zarah; Woods, Nicole; Dore, Kelly; Neville, Alan; Norman, Geoffrey

2017-02-01

Transfer of basic science aids novices in the development of clinical reasoning. The literature suggests that although transfer is often difficult for novices, it can be optimised by two complementary strategies: (i) focusing learners on conceptual knowledge of basic science or (ii) exposing learners to multiple contexts in which the basic science concepts may apply. The relative efficacy of each strategy as well as the mechanisms that facilitate transfer are unknown. In two sequential experiments, we compared both strategies and explored mechanistic changes in how learners address new transfer problems. Experiment 1 was a 2 × 3 design in which participants were randomised to learn three physiology concepts with or without emphasis on the conceptual structure of basic science via illustrative analogies and by means of one, two or three contexts during practice (operationalised as organ systems). Transfer of these concepts to explain pathologies in familiar organ systems (near transfer) and unfamiliar organ systems (far transfer) was evaluated during immediate and delayed testing. Experiment 2 examined whether exposure to conceptual analogies and multiple contexts changed how learners classified new problems. Experiment 1 showed that increasing context variation significantly improved far transfer performance but there was no difference between two and three contexts during practice. Similarly, the increased conceptual analogies led to higher performance for far transfer. Both interventions had independent but additive effects on overall performance. Experiment 2 showed that such analogies and context variation caused learners to shift to using structural characteristics to classify new problems even when there was superficial similarity to previous examples. Understanding problems based on conceptual structural characteristics is necessary for successful transfer. Transfer of basic science can be optimised by using multiple strategies that collectively emphasise

A stochastic wind turbine wake model based on new metrics for wake characterization: A stochastic wind turbine wake model based on new metrics for wake characterization

DOE Office of Scientific and Technical Information (OSTI.GOV)

Doubrawa, Paula; Barthelmie, Rebecca J.; Wang, Hui

Understanding the detailed dynamics of wind turbine wakes is critical to predicting the performance and maximizing the efficiency of wind farms. This knowledge requires atmospheric data at a high spatial and temporal resolution, which are not easily obtained from direct measurements. Therefore, research is often based on numerical models, which vary in fidelity and computational cost. The simplest models produce axisymmetric wakes and are only valid beyond the near wake. Higher-fidelity results can be obtained by solving the filtered Navier-Stokes equations at a resolution that is sufficient to resolve the relevant turbulence scales. This work addresses the gap between thesemore » two extremes by proposing a stochastic model that produces an unsteady asymmetric wake. The model is developed based on a large-eddy simulation (LES) of an offshore wind farm. Because there are several ways of characterizing wakes, the first part of this work explores different approaches to defining global wake characteristics. From these, a model is developed that captures essential features of a LES-generated wake at a small fraction of the cost. The synthetic wake successfully reproduces the mean characteristics of the original LES wake, including its area and stretching patterns, and statistics of the mean azimuthal radius. The mean and standard deviation of the wake width and height are also reproduced. This preliminary study focuses on reproducing the wake shape, while future work will incorporate velocity deficit and meandering, as well as different stability scenarios.« less

Cosmic string wakes

NASA Technical Reports Server (NTRS)

Stebbins, Albert; Veeraraghavan, Shoba; Silk, Joseph; Brandenberger, Robert; Turok, Neil

1987-01-01

Accretion of matter onto wakes left behind by horizon-sized pieces of cosmic string is investigated, and the effects of wakes on the large-scale structure of the universe are determined. Accretion of cold matter onto wakes, the effects of a long string on fluids with finite velocity dispersion or sound speeds, the interactions between loops and wakes, and the conditions for wakes to survive disruption by loops are discussed. It is concluded that the most important wakes are those which were formed at the time of equal matter and radiation density. This leads to sheetlike overdense regions of galaxies with a mean separation in agreement with the scale of the bubbles of de Lapparent, Geller, and Huchra (1986). However, for the value of G(mu) favored from galaxy formation considerations in a universe with cold dark matter, a wake accretes matter from a distance of only about 1.5 Mpc, which is much less than the distance between the wakes.

Tendon basic science: Development, repair, regeneration, and healing.

PubMed

Andarawis-Puri, Nelly; Flatow, Evan L; Soslowsky, Louis J

2015-06-01

Tendinopathy and tendon rupture are common and disabling musculoskeletal conditions. Despite the prevalence of these injuries, a limited number of investigators are conducting fundamental, basic science studies focused on understanding processes governing tendinopathies and tendon healing. Development of effective therapeutics is hindered by the lack of fundamental guiding data on the biology of tendon development, signal transduction, mechanotransduction, and basic mechanisms underlying tendon pathogenesis and healing. To propel much needed progress, the New Frontiers in Tendon Research Conference, co-sponsored by NIAMS/NIH, the Orthopaedic Research Society, and the Icahn School of Medicine at Mount Sinai, was held to promote exchange of ideas between tendon researchers and basic science experts from outside the tendon field. Discussed research areas that are underdeveloped and represent major hurdles to the progress of the field will be presented in this review. To address some of these outstanding questions, conference discussions and breakout sessions focused on six topic areas (Cell Biology and Mechanics, Functional Extracellular Matrix, Development, Mechano-biology, Scarless Healing, and Mechanisms of Injury and Repair), which are reviewed in this special issue and briefly presented in this review. Review articles in this special issue summarize the progress in the field and identify essential new research directions. © 2015 Orthopaedic Research Society. Published by Wiley Periodicals, Inc.

Basic science research and education: a priority for training and capacity building in developing countries.

PubMed

Deckelbaum, Richard J; Ntambi, James M; Wolgemuth, Debra J

2011-09-01

This article provides evidence that basic science research and education should be key priorities for global health training, capacity building, and practice. Currently, there are tremendous gaps between strong science education and research in developed countries (the North) as compared to developing countries (the South). In addition, science research and education appear as low priorities in many developing countries. The need to stress basic science research beyond the typical investment of infectious disease basic service and research laboratories in developing areas is significant in terms of the benefits, not only to education, but also for economic strengthening and development of human resources. There are some indications that appreciation of basic science research education and training is increasing, but this still needs to be applied more rigorously and strengthened systematically in developing countries. Copyright © 2011 Elsevier Inc. All rights reserved.

Numerical investigations of wake interactions of two wind turbines in tandem

NASA Astrophysics Data System (ADS)

Qian, Yaoru; Wang, Tongguang

2018-05-01

Aerodynamic performance and wake interactions between two wind turbine models under different layouts are investigated numerically using large eddy simulation in conjunction with actuator line method based on the “Blind Test” series wind tunnel experiments from Norwegian University of Science and Technology. Numerical results of the power and thrust coefficients of the two rotors and wake characteristics are in good agreement with the experimental measurements. Extended investigations emphasizing the influence of different layout arrangements on the downstream rotor performance and wake development are conducted. Results show that layout arrangements have great influence on the power and thrust prediction of the downstream turbine.

BASIC ELECTRICITY. SCIENCE IN ACTION SERIES, NUMBER 14.

ERIC Educational Resources Information Center

CASSEL, RICHARD

THIS TEACHING GUIDE, INVOLVING ACTIVITIES FOR DEVELOPING AN UNDERSTANDING OF BASIC ELECTRICITY, EMPHASIZES STUDENT INVESTIGATIONS RATHER THAN FACTS, AND IS BASED ON THE PREMISE THAT THE MAJOR GOAL IN SCIENCE TEACHING IS THE DEVELOPMENT OF THE INVESTIGATIVE ATTITUDE IN THE STUDENT. ACTIVITIES SUGGESTED INVOLVE SIMPLE DEMONSTRATIONS AND EXPERIMENTS…

Is basic science disappearing from medicine? The decline of biomedical research in the medical literature.

PubMed

Steinberg, Benjamin E; Goldenberg, Neil M; Fairn, Gregory D; Kuebler, Wolfgang M; Slutsky, Arthur S; Lee, Warren L

2016-02-01

Explosive growth in our understanding of genomics and molecular biology have fueled calls for the pursuit of personalized medicine, the notion of harnessing biologic variability to provide patient-specific care. This vision will necessitate a deep understanding of the underlying pathophysiology in each patient. Medical journals play a pivotal role in the education of trainees and clinicians, yet we suspected that the amount of basic science in the top medical journals has been in decline. We conducted an automated search strategy in PubMed to identify basic science articles and calculated the proportion of articles dealing with basic science in the highest impact journals for 8 different medical specialties from 1994 to 2013. We observed a steep decline (40-60%) in such articles over time in almost all of the journals examined. This rapid decline in basic science from medical journals is likely to affect practitioners' understanding of and interest in the basic mechanisms of disease and therapy. In this Life Sciences Forum, we discuss why this decline may be occurring and what it means for the future of science and medicine. © FASEB.

Direct Numerical Simulations of Transitional/Turbulent Wakes

NASA Technical Reports Server (NTRS)

Rai, Man Mohan

2011-01-01

The interest in transitional/turbulent wakes spans the spectrum from an intellectual pursuit to understand the complex underlying physics to a critical need in aeronautical engineering and other disciplines to predict component/system performance and reliability. Cylinder wakes have been studied extensively over several decades to gain a better understanding of the basic flow phenomena that are encountered in such flows. Experimental, computational and theoretical means have been employed in this effort. While much has been accomplished there are many important issues that need to be resolved. The physics of the very near wake of the cylinder (less than three diameters downstream) is perhaps the most challenging of them all. This region comprises the two detached shear layers, the recirculation region and wake flow. The interaction amongst these three components is to some extent still a matter of conjecture. Experimental techniques have generated a large percentage of the data that have provided us with the current state of understanding of the subject. More recently computational techniques have been used to simulate cylinder wakes, and the data from such simulations are being used to both refine our understanding of such flows as well as provide new insights. A few large eddy and direct numerical simulations (LES and DNS) of cylinder wakes have appeared in the literature in the recent past. These investigations focus on the low Reynolds number range where the cylinder boundary layer is laminar (sub-critical range). However, from an engineering point of view, there is considerable interest in the situation where the upper and/or lower boundary layer of an airfoil is turbulent, and these turbulent boundary layers separate from the airfoil to contribute to the formation of the wake downstream. In the case of cylinders, this only occurs at relatively large unit Reynolds numbers. However, in the case of airfoils, the boundary layer has the opportunity to transition

PROJECT SUCCESS: Marine Science. (Introductory Packet, Basic Marine Science Laboratory Techniques, Oceanographic Instruments, Individual Projects, Bibliography).

ERIC Educational Resources Information Center

Demaray, Bryan

Five packets comprise the marine science component of an enrichment program for gifted elementary students. Considered in the introductory section are identification (pre/post measure) procedures. Remaining packets address the following topics (subtopics in parentheses): basic marine science laboratory techniques (microscope techniques and metric…

Japanese representation in leading general medicine and basic science journals: a comparison of two decades.

PubMed

Fukui, Tsuguya; Takahashi, Osamu; Rahman, Mahbubur

2013-11-01

During 1991-2000, Japan contribution to the top general medicine journals was very small although the contribution to the top basic science journals was sizeable. However, it has not been examined whether the contribution to the top general medicine and basic science journals has changed during the last decade (2001-2010). The objective of this study was to compare Japan representation in high-impact general medicine and basic science journals between the years 1991-2000 and 2001-2010. We used PubMed database to examine the frequency of articles originated from Japan and published in 7 high-impact general medicine and 6 high-impact basic science journals. Several Boolean operators were used to connect name of the journal, year of publication and corresponding authors' affiliation in Japan. Compared to the 1991-2000 decade, Japan contribution to the top general medicine journals did not increase over the 2001-2010 period (0.66% vs. 0.74%, P = 0.255). However, compared to the same period, its contribution to the top basic science journals increased during 2001-2010 (2.51% vs. 3.60%, P < 0.001). Japan representation in basic science journals showed an upward trend over the 1991-2000 period (P < 0.001) but remained flat during 2001-2010 (P = 0.177). In contrast, the trend of Japan representation in general medicine journals remained flat both during 1991-2000 (P = 0.273) and 2001-2010 (P = 0.073). Overall, Japan contribution to the top general medicine journals has remained small and unchanged over the last two decades. However, top basic science journals had higher Japan representation during 2001-2010 compared to 1991-2000.

Coalescing Wind Turbine Wakes

DOE PAGES

Lee, S.; Churchfield, M.; Sirnivas, S.; ...

2015-06-18

A team of researchers from the National Renewable Energy Laboratory and Statoil used large-eddy simulations to numerically investigate the merging wakes from upstream offshore wind turbines. Merging wakes are typical phenomena in wind farm flows in which neighboring turbine wakes consolidate to form complex flow patterns that are as yet not well understood. In the present study, three 6-MW turbines in a row were subjected to a neutrally stable atmospheric boundary layer flow. As a result, the wake from the farthest upstream turbine conjoined the downstream wake, which significantly altered the subsequent velocity deficit structures, turbulence intensity, and the globalmore » meandering behavior. The complexity increased even more when the combined wakes from the two upstream turbines mixed with the wake generated by the last turbine, thereby forming a "triplet" structure. Although the influence of the wake generated by the first turbine decayed with downstream distance, the mutated wakes from the second turbine continued to influence the downstream wake. Two mirror-image angles of wind directions that yielded partial wakes impinging on the downstream turbines yielded asymmetric wake profiles that could be attributed to the changing flow directions in the rotor plane induced by the Coriolis force. In conclusion, the turbine wakes persisted for extended distances in the present study, which is a result of low aerodynamic surface roughness typically found in offshore conditions« less

BRIDGES: Evolution of basic and applied linkages in benthic science

USGS Publications Warehouse

Aumen, Nicholas G.; Gurtz, Martin E.; Barbour, Michael T.; Moerke, Ashley

2010-01-01

Growing awareness of environmental degradation resulted in stricter environmental regulations and laws for aquatic ecosystems. These regulations were followed by an increase in applied research and monitoring beginning in the early 1970s. The number of applied scientists who were members of the North American Benthological Society grew at a commensurate rate. The editors of J-NABS recognized that, despite these increases, submitted manuscripts mostly addressed basic science. In response, the BRIDGES section of J-NABS was created in 1994 to provide a forum for linking basic ecological principles to applied science problems and issues. We examined the emergence of applied science topics in J-NABS and its predecessor, Freshwater Invertebrate Biology, from their beginning in 1982 to 2009. We classified papers among 11 categories that included a basic/applied science linkage. In the 1980s, applied papers were predominantly on effects of eutrophication/pollution and landuse changes. When BRIDGES was established in 1994, papers were solicited by editors and BRIDGES sections usually included >1 paper on a common theme to express complementary or alternate viewpoints. Forty-two papers appeared in BRIDGES between 1994 and 2009, but the number per issue declined after 2001. The total number of applied science papers in J-NABS has increased since ∼1994. Citation analysis of BRIDGES papers illustrates how information is being cited, but applied papers often are used in ways that might not lead to citations. BRIDGES transitioned to a new format in September 2009 to address new types of complex, multifaceted linkages. All new BRIDGES articles will be open access, and authors will be encouraged to produce lay-language fact sheets and to post them on the web.

Interprofessional education and the basic sciences: Rationale and outcomes.

PubMed

Thistlethwaite, Jill E

2015-01-01

Interprofessional education (IPE) aims to improve patient outcomes and the quality of care. Interprofessional learning outcomes and interprofessional competencies are now included in many countries' health and social care professions' accreditation standards. While IPE may take place at any time in health professions curricula it tends to focus on professionalism and clinical topics rather than basic science activities. However generic interprofessional competencies could be included in basic science courses that are offered to at least two different professional groups. In developing interprofessional activities at the preclinical level, it is important to define explicit interprofessional learning outcomes plus the content and process of the learning. Interprofessional education must involve interactive learning processes and integration of theory and practice. This paper provides examples of IPE in anatomy and makes recommendations for course development and evaluation. © 2015 American Association of Anatomists.

Teaching basic science to optimize transfer.

PubMed

Norman, Geoff

2009-09-01

Basic science teachers share the concern that much of what they teach is soon forgotten. Although some evidence suggests that relatively little basic science is forgotten, it may not appear so, as students commonly have difficulty using these concepts to solve or explain clinical problems: This phenomenon, using a concept learned in one context to solve a problem in a different context, is known to cognitive psychologists as transfer. The psychology literature shows that transfer is difficult; typically, even though students may know a concept, fewer than 30% will be able to use it to solve new problems. However a number of strategies to improve transfer can be adopted at the time of initial teaching of the concept, in the use of exemplars to illustrate the concept, and in practice with additional problems. In this article, we review the literature in psychology to identify practical strategies to improve transfer. Critical review of psychology literature to identify factors that enhance or impede transfer. There are a number of strategies available to teachers to facilitate transfer. These include active problem-solving at the time of initial learning, imbedding the concept in a problem context, using everyday analogies, and critically, practice with multiple dissimilar problems. Further, mixed practice, where problems illustrating different concepts are mixed together, and distributed practice, spread out over time, can result in significant and large gains. Transfer is difficult, but specific teaching strategies can enhance this skill by factors of two or three.

Basic Science Considerations in Primary Total Hip Replacement Arthroplasty

PubMed Central

Mirza, Saqeb B; Dunlop, Douglas G; Panesar, Sukhmeet S; Naqvi, Syed G; Gangoo, Shafat; Salih, Saif

2010-01-01

Total Hip Replacement is one of the most common operations performed in the developed world today. An increasingly ageing population means that the numbers of people undergoing this operation is set to rise. There are a numerous number of prosthesis on the market and it is often difficult to choose between them. It is therefore necessary to have a good understanding of the basic scientific principles in Total Hip Replacement and the evidence base underpinning them. This paper reviews the relevant anatomical and biomechanical principles in THA. It goes on to elaborate on the structural properties of materials used in modern implants and looks at the evidence base for different types of fixation including cemented and uncemented components. Modern bearing surfaces are discussed in addition to the scientific basis of various surface engineering modifications in THA prostheses. The basic science considerations in component alignment and abductor tension are also discussed. A brief discussion on modular and custom designs of THR is also included. This article reviews basic science concepts and the rationale underpinning the use of the femoral and acetabular component in total hip replacement. PMID:20582240

Basic Science for a Secure Energy Future

NASA Astrophysics Data System (ADS)

Horton, Linda

2010-03-01

Anticipating a doubling in the world's energy use by the year 2050 coupled with an increasing focus on clean energy technologies, there is a national imperative for new energy technologies and improved energy efficiency. The Department of Energy's Office of Basic Energy Sciences (BES) supports fundamental research that provides the foundations for new energy technologies and supports DOE missions in energy, environment, and national security. The research crosses the full spectrum of materials and chemical sciences, as well as aspects of biosciences and geosciences, with a focus on understanding, predicting, and ultimately controlling matter and energy at electronic, atomic, and molecular levels. In addition, BES is the home for national user facilities for x-ray, neutron, nanoscale sciences, and electron beam characterization that serve over 10,000 users annually. To provide a strategic focus for these programs, BES has held a series of ``Basic Research Needs'' workshops on a number of energy topics over the past 6 years. These workshops have defined a number of research priorities in areas related to renewable, fossil, and nuclear energy -- as well as cross-cutting scientific grand challenges. These directions have helped to define the research for the recently established Energy Frontier Research Centers (EFRCs) and are foundational for the newly announced Energy Innovation Hubs. This overview will review the current BES research portfolio, including the EFRCs and user facilities, will highlight past research that has had an impact on energy technologies, and will discuss future directions as defined through the BES workshops and research opportunities.

The Relationship between Immediate Relevant Basic Science Knowledge and Clinical Knowledge: Physiology Knowledge and Transthoracic Echocardiography Image Interpretation

ERIC Educational Resources Information Center

Nielsen, Dorte Guldbrand; Gotzsche, Ole; Sonne, Ole; Eika, Berit

2012-01-01

Two major views on the relationship between basic science knowledge and clinical knowledge stand out; the Two-world view seeing basic science and clinical science as two separate knowledge bases and the encapsulated knowledge view stating that basic science knowledge plays an overt role being encapsulated in the clinical knowledge. However, resent…

Estimating lift from unsteady wakes by using the Kutta-Joukowski theorem with vorticity-weighted wake width

NASA Astrophysics Data System (ADS)

Wang, Shizhao; He, Guowei; Liu, Tianshu

2017-11-01

The Kutta-Joukowski (KJ) theorem usually leads to puzzling results when it is applied to estimating the lift from the unsteady wakes generated by flapping wings. We investigate this problem by using a prevalent flapping rectangular wing model, where the unsteady wakes are obtained by numerically solving the Navier-Stokes equations at a low Reynolds number. It is found that neither the unsteady nor the time-averaged lift coefficient is correctly predicted when the parameters for the KJ theorem are selected according to the widely accepted ways in the literature. We propose a vorticity-weighted wake width model based on the vortex impulse theory to improve the prediction of the time-averaged lift. Furthermore, we investigate the phase difference of unsteady lift caused by the quasi-steady assumption of the application of the KJ theorem to the flapping flight and quantitatively link the phase difference to the local fluid acceleration. We show the phase difference can be corrected by using an added mass lift model. This work is helpful to clarify the error in estimating the lift of animal flight. Supported by the National Natural Science Foundation of China (No. 11672305).

Evaluation of Fast-Time Wake Vortex Models using Wake Encounter Flight Test Data

NASA Technical Reports Server (NTRS)

Ahmad, Nashat N.; VanValkenburg, Randal L.; Bowles, Roland L.; Limon Duparcmeur, Fanny M.; Gloudesman, Thijs; van Lochem, Sander; Ras, Eelco

2014-01-01

This paper describes a methodology for the integration and evaluation of fast-time wake models with flight data. The National Aeronautics and Space Administration conducted detailed flight tests in 1995 and 1997 under the Aircraft Vortex Spacing System Program to characterize wake vortex decay and wake encounter dynamics. In this study, data collected during Flight 705 were used to evaluate NASA's fast-time wake transport and decay models. Deterministic and Monte-Carlo simulations were conducted to define wake hazard bounds behind the wake generator. The methodology described in this paper can be used for further validation of fast-time wake models using en-route flight data, and for determining wake turbulence constraints in the design of air traffic management concepts.

Beta EEG reflects sensory processing in active wakefulness and homeostatic sleep drive in quiet wakefulness.

PubMed

Grønli, Janne; Rempe, Michael J; Clegern, William C; Schmidt, Michelle; Wisor, Jonathan P

2016-06-01

Markers of sleep drive (<10 Hz; slow-wave activity and theta) have been identified in the course of slow-wave sleep and wakefulness. So far, higher frequencies in the waking electroencephalogram have not been examined thoroughly as a function of sleep drive. Here, electroencephalogram dynamics were measured in epochs of active wake (wake characterized by high muscle tone) or quiet wake (wake characterized by low muscle tone). It was hypothesized that the higher beta oscillations (15-35 Hz, measured by local field potential and electroencephalography) represent fundamentally different processes in active wake and quiet wake. In active wake, sensory stimulation elevated beta activity in parallel with gamma (80-90 Hz) activity, indicative of cognitive processing. In quiet wake, beta activity paralleled slow-wave activity (1-4 Hz) and theta (5-8 Hz) in tracking sleep need. Cerebral lactate concentration, a measure of cerebral glucose utilization, increased during active wake whereas it declined during quiet wake. Mathematical modelling of state-dependent dynamics of cortical lactate concentration was more precisely predictive when quiet wake and active wake were included as two distinct substates rather than a uniform state of wakefulness. The extent to which lactate concentration declined in quiet wake and increased in active wake was proportionate to the amount of beta activity. These data distinguish quiet wake from active wake. Quiet wake, particularly when characterized by beta activity, is permissive to metabolic and electrophysiological changes that occur in slow-wave sleep. These data urge further studies on state-dependent beta oscillations across species. © 2016 European Sleep Research Society.

Vortex Wakes of Conventional Aircraft

DTIC Science & Technology

1975-05-01

Research Laboratories, Wright-Patterson Air Force Base , Ohio 45433, USA This work was prepared at the request of the Fluid Dynamics Panel of AGARD. THE...aerospace sciences relevant to strengthening the common defence posture; - Improving the co-operation among member nations in aerospace research and...two models have been developed to describe the inviscid structure of the vortex wake. The first model was due to Prandtl [10] and is based on the

ERK signaling pathway regulates sleep duration through activity-induced gene expression during wakefulness.

PubMed

Mikhail, Cyril; Vaucher, Angélique; Jimenez, Sonia; Tafti, Mehdi

2017-01-24

Wakefulness is accompanied by experience-dependent synaptic plasticity and an increase in activity-regulated gene transcription. Wake-induced genes are certainly markers of neuronal activity and may also directly regulate the duration of and need for sleep. We stimulated murine cortical cultures with the neuromodulatory signals that are known to control wakefulness in the brain and found that norepinephrine alone or a mixture of these neuromodulators induced activity-regulated gene transcription. Pharmacological inhibition of the various signaling pathways involved in the regulation of gene expression indicated that the extracellular signal-regulated kinase (ERK) pathway is the principal one mediating the effects of waking neuromodulators on gene expression. In mice, ERK phosphorylation in the cortex increased and decreased with wakefulness and sleep. Whole-body or cortical neuron-specific deletion of Erk1 or Erk2 significantly increased the duration of wakefulness in mice, and pharmacological inhibition of ERK phosphorylation decreased sleep duration and increased the duration of wakefulness bouts. Thus, this signaling pathway, which is highly conserved from Drosophila to mammals, is a key pathway that links waking experience-induced neuronal gene expression to sleep duration and quality. Copyright © 2017, American Association for the Advancement of Science.

Improving Learning in Science and Basic Skills among Diverse Student Populations.

ERIC Educational Resources Information Center

Sutman, Francis X.; Guzman, Ana

This monograph is a rich resource of information designed to strengthen science and basic skills teaching, and improve learning for limited English proficient (LEP) minority student populations. It proposes the use of hands-on science investigations as the driving force for mathematics and English language development. The materials included in…

Airloads, wakes, and aeroelasticity

NASA Technical Reports Server (NTRS)

Johnson, Wayne

1990-01-01

Fundamental considerations regarding the theory of modeling of rotary wing airloads, wakes, and aeroelasticity are presented. The topics covered are: airloads and wakes, including lifting-line theory, wake models and nonuniform inflow, free wake geometry, and blade-vortex interaction; aerodynamic and wake models for aeroelasticity, including two-dimensional unsteady aerodynamics and dynamic inflow; and airloads and structural dynamics, including comprehensive airload prediction programs. Results of calculations and correlations are presented.

A simulation for teaching the basic and clinical science of fluid therapy.

PubMed

Rawson, Richard E; Dispensa, Marilyn E; Goldstein, Richard E; Nicholson, Kimberley W; Vidal, Noni Korf

2009-09-01

The course "Management of Fluid and Electrolyte Disorders" is an applied physiology course taught using lectures and paper-based cases. The course approaches fluid therapy from both basic science and clinical perspectives. While paper cases provide a basis for application of basic science concepts, they lack key components of genuine clinical cases that, by nature, are diverse, change over time, and respond in unique ways to therapeutic interventions. We developed a dynamic model using STELLA software that simulates normal and abnormal fluid and electrolyte balance in the dog. Students interact, not with the underlying model, but with a user interface that provides sufficient data (skin turgor, chemistry panel, etc.) for the clinical assessment of patients and an opportunity for treatment. Students administer fluids and supplements, and the model responds in "real time," requiring regular reassessment and, potentially, adaptation of the treatment strategy. The level of success is determined by clinical outcome, including improvement, deterioration, or death. We expected that the simulated cases could be used to teach both the clinical and basic science of fluid therapy. The simulation provides exposure to a realistic clinical environment, and students tend to focus on this aspect of the simulation while, for the most part, ignoring an exploration of the underlying physiological basis for patient responses. We discuss how the instructor's expertise can provide sufficient support, feedback, and scaffolding so that students can extract maximum understanding of the basic science in the context of assessing and treating at the clinical level.

There was less self-critique among basic than in clinical science articles in three rheumatology journals.

PubMed

Yazici, Hasan; Gogus, Feride; Esen, Fehim; Yazici, Yusuf

2014-06-01

There is concern that self-critique with authors acknowledging limitations of their work is not given due importance in scientific articles. We had the impression that this was more true for articles in basic compared with clinical science. We thus surveyed for the presence of self-critique in the discussion sections of the original articles in three rheumatology journals with attention to differences between the basic and the clinical science articles. The discussion sections of the original articles in January, May, and September 2012 issues of Annals of the Rheumatic Diseases, Arthritis and Rheumatism, and Rheumatology (Oxford) were surveyed (n = 223) after classifying each article as mainly related to clinical or basic science. The discussion sections were electronically scanned by two observers for the presence of the root word "limit" or its derivatives who also read each discussion section for the presence of any limitations otherwise voiced. A limitation discussion in any form was present in only 19 (20.2%) or 29 (30.1%) of 94 basic science vs. 95 (73.6%) or 107 (82.3%) of 129 clinical science articles (P < 0.0001 for either observer). Self-critique, especially lacking in basic science articles, should be given due attention. Copyright © 2014 Elsevier Inc. All rights reserved.

A Candidate Wake Vortex Strength Definition for Application to the NASA Aircraft Vortex Spacing System (AVOSS)

NASA Technical Reports Server (NTRS)

Hinton, David A.; Tatnall, Chris R.

1997-01-01

A significant effort is underway at NASA Langley to develop a system to provide dynamical aircraft wake vortex spacing criteria to Air Traffic Control (ATC). The system under development, the Aircraft Vortex Spacing System (AVOSS), combines the inputs of multiple subsystems to provide separation matrices with sufficient stability for use by ATC and sufficient monitoring to ensure safety. The subsystems include a meteorological subsystem, a wake behavior prediction subsystem, a wake sensor subsystem, and system integration and ATC interfaces. The proposed AVOSS is capable of using two factors, singly or in combination, for reducing in-trail spacing. These factors are wake vortex motion out of a predefined approach corridor and wake decay below a strength that is acceptable for encounter. Although basic research into the wake phenomena has historically used wake total circulation as a strength parameter, there is a requirement for a more specific strength definition that may be applied across multiple disciplines and teams to produce a real-time, automated system. This paper presents some of the limitations of previous applications of circulation to aircraft wake observations and describes the results of a preliminary effort to bound a spacing system strength definition.

The stability to two-dimensional wakes and shear layers at high Mach numbers

NASA Technical Reports Server (NTRS)

Papageorgiou, Demetrios T.

1991-01-01

This study is concerned with the stability properties of laminar free-shear-layer flows, and in particular symmetric two-dimensional wakes, for the supersonic through the hypersonic regimes. Emphasis is given to the use of proper wake profiles that satisfy the equations of motion at high Reynolds numbers. In particular the inviscid stability of a developing two-dimensional wake is studied as it accelerates at the trailing edge of a splitter plate. The nonparallelism of the flow is a leading-order effect in the calculation of the basic state, which is obtained numerically. Neutral stability characteristics are computed and the hypersonic stability is obtained by increasing the Mach number. It is found that the stability characteristics are altered significantly as the wake develops. Multiple modes (secondary modes) are found in the near wake that are closely related to the corresponding Blasius ones, but as the wake develops mode multiplicity is delayed to higher and higher Mach numbers. At a distance of about one plate length from the trailing edge, there is only one mode in a Mach number range of 0-20. The dominant mode emerging at all wake stations, and for high enough Mach numbers, is the so-called vorticity mode that is centered around the generalized inflection point layer. The structure of the dominant mode is also obtained analytically for all streamwise wake locations and it is shown how the far-wake limit is approached. Asymptotic results for the hypersonic mixing layer given by a tanh and a Lock distribution are also given.

Recent NASA Wake-Vortex Flight Tests, Flow-Physics Database and Wake-Development Analysis

NASA Technical Reports Server (NTRS)

Vicroy, Dan D.; Vijgen, Paul M.; Reimer, Heidi M.; Gallegos, Joey L.; Spalart, Philippe R.

1998-01-01

A series of flight tests over the ocean of a four engine turboprop airplane in the cruise configuration have provided a data set for improved understanding of wake vortex physics and atmospheric interaction. An integrated database has been compiled for wake characterization and validation of wake-vortex computational models. This paper describes the wake-vortex flight tests, the data processing, the database development and access, and results obtained from preliminary wake-characterization analysis using the data sets.

Limitations on diversity in basic science departments.

PubMed

Leboy, Phoebe S; Madden, Janice F

2012-08-01

It has been over 30 years since the beginning of efforts to improve diversity in academia. We can identify four major stages: (1) early and continuing efforts to diversify the pipeline by increasing numbers of women and minorities getting advanced degrees, particularly in science, technology, engineering, and math (STEM); (2) requiring academic institutions to develop their own "affirmative action plans" for hiring and promotion; (3) introducing mentoring programs and coping strategies to help women and minorities deal with faculty practices from an earlier era; (4) asking academic institutions to rethink their practices and policies with an eye toward enabling more faculty diversity, a process known as institutional transformation. The thesis of this article is that research-intensive basic science departments of highly ranked U.S. medical schools are stuck at stage 3, resulting in a less diverse tenured and tenure-track faculty than seen in well-funded science departments of major universities. A review of Web-based records of research-intensive departments in universities with both medical school and nonmedical school departments indicates that the proportion of women and Black faculty in science departments of medical schools is lower than the proportion in similarly research-intensive university science departments. Expectations for faculty productivity in research-intensive medical school departments versus university-based departments may lead to these differences in faculty diversity.

Development and Validation of the Life Sciences Assessment: A Measure of Preschool Children's Conceptions of Basic Life Sciences

ERIC Educational Resources Information Center

Maherally, Uzma Nooreen

2014-01-01

The purpose of this study was to develop and validate a science assessment tool termed the Life Sciences Assessment (LSA) in order to assess preschool children's conceptions of basic life sciences. The hypothesis was that the four sub-constructs, each of which can be measured through a series of questions on the LSA, will make a significant…

White Paper on Nuclear Data Needs and Capabilities for Basic Science

DOE Office of Scientific and Technical Information (OSTI.GOV)

Batchelder, J.; Kawano, T.; Kelley, J.

Reliable nuclear structure and reaction data represent the fundamental building blocks of nuclear physics and astrophysics research, and are also of importance in many applications. There is a continuous demand for high-quality updates of the main nuclear physics databases via the prompt compilation and evaluation of the latest experimental and theoretical results. The nuclear physics research community benefits greatly from comprehensive, systematic and up-to-date reviews of the experimentally determined nuclear properties and observables, as well as from the ability to rapidly access these data in user-friendly forms. Such credible databases also act as a bridge between science, technology, and societymore » by making the results of basic nuclear physics research available to a broad audience of users, and hence expand the societal utilization of nuclear science. Compilation and evaluation of nuclear data has deep roots in the history of nuclear science research, as outlined in Appendix 1. They have an enormous impact on many areas of science and applications, as illustrated in Figure 2 for the Evaluated Nuclear Structure Data File (ENSDF) database. The present workshop concentrated on the needs of the basic nuclear science community for data and capabilities. The main role of this community is to generate and use data in order to understand the basic nuclear forces and interactions that are responsible for the existence and the properties of all nuclides and, as a consequence, to gain knowledge about the origins, evolution and structure of the universe. Thus, the experiments designed to measure a wealth of nuclear properties towards these fundamental scientific goals are typically performed from within this community.« less

Dental sciences related articles data published in a Basic Medical Sciences Journal from Iran.

PubMed

Shamim, Thorakkal

2018-04-01

This data aimed to audit the dental sciences related articles published in Iranian Journal of Basic Medical Sciences (IJBMS) from 2007 to 2015 over a 9 year period performed using web-based search. The data were analyzed for topic of dental sciences, type of article, international collaborations, source of funding, number of authors and authorship trends. Out of the total 18 data related to dental sciences, original articles (12), review articles (4) and short communications (2) contribute the major share. Regarding the relationship with dental sciences, the maximum number of data were related to oral pathology and microbiology (16) followed by oral medicine and radiology (7) and periodontics (7). Among the data related to dental sciences, oral cancer (3) and gingival and periodontal diseases (3) followed by dental plaque and caries (2) and orthodontic tooth movement (2) form the major attraction of the contributors. The largest numbers of data related to dental sciences were received from Mashhad University of Medical Sciences, Mashhad (4) and Tehran University of Medical Sciences,Tehran (2).The present data were compared with previous bibliometric studies done related to dental sciences (Shamim et al., 2017a, 2017b).

Teachers' Involvement in Implementing the Basic Science and Technology Curriculum of the Nine-Year Basic Education

ERIC Educational Resources Information Center

Odili, John Nwanibeze; Ebisine, Sele Sylvester; Ajuar, Helen Nwakaife

2011-01-01

The study investigated teachers' involvement in implementing the basic science and technology curriculum in primary schools in WSLGA (Warri South Local Government Area) of Delta State. It sought to identify the availability of the document in primary schools and teachers' knowledge of the objectives and activities specified in the curriculum.…

Paired basic science and clinical problem-based learning faculty teaching side by side: do students evaluate them differently?

PubMed

Stevenson, Frazier T; Bowe, Connie M; Gandour-Edwards, Regina; Kumari, Vijaya G

2005-02-01

Many studies have evaluated the desirability of expert versus non-expert facilitators in problem-based learning (PBL), but performance differences between basic science and clinical facilitators has been less studied. In a PBL course at our university, pairs of faculty facilitators (1 clinician, 1 basic scientist) were assigned to student groups to maximise integration of basic science with clinical science. This study set out to establish whether students evaluate basic science and clinical faculty members differently when they teach side by side. Online questionnaires were used to survey 188 students about their faculty facilitators immediately after they completed each of 3 serial PBL cases. Overall satisfaction was measured using a scale of 1-7 and yes/no responses were gathered from closed questions describing faculty performance. results: Year 1 students rated basic science and clinical facilitators the same, but Year 2 students rated the clinicians higher overall. Year 1 students rated basic scientists higher in their ability to understand the limits of their own knowledge. Year 2 students rated the clinicians higher in several content expertise-linked areas: preparedness, promotion of in-depth understanding, and ability to focus the group, and down-rated the basic scientists for demonstrating overspecialised knowledge. Students' overall ratings of individual faculty best correlated with the qualities of stimulation, focus and preparedness, but not with overspecialisation, excessive interjection of the faculty member's own opinions, and encouragement of psychosocial issue discussion. When taught by paired basic science and clinical PBL facilitators, students in Year 1 rated basic science and clinical PBL faculty equally, while Year 2 students rated clinicians more highly overall. The Year 2 difference may be explained by perceived differences in content expertise.

Science Awareness and Science Literacy through the Basic Physics Course: Physics with a bit of Metaphysics?

NASA Astrophysics Data System (ADS)

Rusli, Aloysius

2016-08-01

Until the 1980s, it is well known and practiced in Indonesian Basic Physics courses, to present physics by its effective technicalities: The ideally elastic spring, the pulley and moving blocks, the thermodynamics of ideal engine models, theoretical electrostatics and electrodynamics with model capacitors and inductors, wave behavior and its various superpositions, and hopefully closed with a modern physics description. A different approach was then also experimented with, using the Hobson and Moore texts, stressing the alternative aim of fostering awareness, not just mastery, of science and the scientific method. This is hypothesized to be more in line with the changed attitude of the so-called Millenials cohort who are less attentive if not interested, and are more used to multi-tasking which suits their shorter span of attention. The upside is increased awareness of science and the scientific method. The downside is that they are getting less experience of the scientific method which intensely bases itself on critical observation, analytic thinking to set up conclusions or hypotheses, and checking consistency of the hypotheses with measured data. Another aspect is recognition that the human person encompasses both the reasoning capacity and the mental- spiritual-cultural capacity. This is considered essential, as the world grows even smaller due to increased communication capacity, causing strong interactions, nonlinear effects, and showing that value systems become more challenging and challenged due to physics / science and its cosmology, which is successfully based on the scientific method. So students should be made aware of the common basis of these two capacities: the assumptions, the reasoning capacity and the consistency assumption. This shows that the limits of science are their set of basic quantifiable assumptions, and the limits of the mental-spiritual-cultural aspects of life are their set of basic metaphysical (non-quantifiable) assumptions. The

Examining the effect of self-explanation on cognitive integration of basic and clinical sciences in novices.

PubMed

Lisk, Kristina; Agur, Anne M R; Woods, Nicole N

2017-12-01

Several studies have shown that cognitive integration of basic and clinical sciences supports diagnostic reasoning in novices; however, there has been limited exploration of the ways in which educators can translate this model of mental activity into sound instructional strategies. The use of self-explanation during learning has the potential to promote and support the development of integrated knowledge by encouraging novices to elaborate on the causal relationship between clinical features and basic science mechanisms. To explore the effect of this strategy, we compared diagnostic efficacy of teaching students (n = 71) the clinical features of four musculoskeletal pathologies using either (1) integrated causal basic science descriptions (BaSci group); (2) integrated causal basic science descriptions combined with self-explanation prompts (SE group); (3) basic science mechanisms segregated from the clinical features (SG group). All participants completed a diagnostic accuracy test immediately after learning and 1-week later. The results showed that the BaSci group performed significantly better compared to the SE (p = 0.019) and SG groups (p = 0.004); however, no difference was observed between the SE and SG groups (p = 0.91). We hypothesize that the structure of the self-explanation task may not have supported the development of a holistic conceptual understanding of each disease. These findings suggest that integration strategies need to be carefully structured and applied in ways that support the holistic story created by integrated basic science instruction in order to foster conceptual coherence and to capitalize on the benefits of cognition integration.

PRP Treatment Efficacy for Tendinopathy: A Review of Basic Science Studies

PubMed Central

2016-01-01

Platelet-Rich Plasma (PRP) has been widely used in orthopaedic surgery and sport medicine to treat tendon injuries. However, the efficacy of PRP treatment for tendinopathy is controversial. This paper focuses on reviewing the basic science studies on PRP performed under well-controlled conditions. Both in vitro and in vivo studies describe PRP's anabolic and anti-inflammatory effects on tendons. While some clinical trials support these findings, others refute them. In this review, we discuss the effectiveness of PRP to treat tendon injuries with evidence presented in basic science studies and the potential reasons for the controversial results in clinical trials. Finally, we comment on the approaches that may be required to improve the efficacy of PRP treatment for tendinopathy. PMID:27610386

In defense of basic science funding: today's scientific discovery is tomorrow's medical advance.

PubMed

Tessier-Lavigne, Marc

2013-06-01

In this address, I will discuss the importance of basic science in tackling our health problems. I will also describe how the funding cuts are damaging our economic competitiveness and turning our young people away from science.

Ultrastructural evidence for synaptic scaling across the wake/sleep cycle.

PubMed

de Vivo, Luisa; Bellesi, Michele; Marshall, William; Bushong, Eric A; Ellisman, Mark H; Tononi, Giulio; Cirelli, Chiara

2017-02-03

It is assumed that synaptic strengthening and weakening balance throughout learning to avoid runaway potentiation and memory interference. However, energetic and informational considerations suggest that potentiation should occur primarily during wake, when animals learn, and depression should occur during sleep. We measured 6920 synapses in mouse motor and sensory cortices using three-dimensional electron microscopy. The axon-spine interface (ASI) decreased ~18% after sleep compared with wake. This decrease was proportional to ASI size, which is indicative of scaling. Scaling was selective, sparing synapses that were large and lacked recycling endosomes. Similar scaling occurred for spine head volume, suggesting a distinction between weaker, more plastic synapses (~80%) and stronger, more stable synapses. These results support the hypothesis that a core function of sleep is to renormalize overall synaptic strength increased by wake. Copyright © 2017, American Association for the Advancement of Science.

Very long-term retention of basic science knowledge in doctors after graduation.

PubMed

Custers, Eugène J F M; Ten Cate, Olle T J

2011-04-01

Despite frequent complaints that biomedical knowledge is quickly forgotten after it has been learned, few investigations of actual long-term retention of basic science knowledge have been conducted in the medical domain. Our aim was to illuminate the long-term retention of basic science knowledge, particularly of unrehearsed knowledge. Using a cross-sectional study design, medical students and doctors in the Netherlands were tested for retention of basic science knowledge. Relationships between retention interval and proportion of correct answers on a knowledge test were investigated. The popular notion that most of basic science knowledge is forgotten shortly after graduation is not supported by our findings. With respect to the full test scores, which reflect a composite of unrehearsed and rehearsed knowledge, performance decreased from approximately 40% correct answers for students still in medical school, to 25-30% correct answers for doctors after many years of practice. When rehearsal during the retention interval is controlled for, it appears that little knowledge is lost for 1.5-2 years after it was last used; from then on, retention is best described by a negatively accelerated (logarithmic) forgetting curve. After ≥ 25 years, retention levels were in the range of 15-20%. Conclusions about the forgetting of unrehearsed knowledge in this study are in line with findings reported in other domains: it proceeds in accordance with the Ebbinghaus curve for meaningful material, except that in our findings the 'downward' part appears to start later than in most other studies. The limitations of the study are discussed and possible ramifications for medical education are proposed. © Blackwell Publishing Ltd 2011.

High-Order Numerical Simulations of Wind Turbine Wakes

NASA Astrophysics Data System (ADS)

Kleusberg, E.; Mikkelsen, R. F.; Schlatter, P.; Ivanell, S.; Henningson, D. S.

2017-05-01

Previous attempts to describe the structure of wind turbine wakes and their mutual interaction were mostly limited to large-eddy and Reynolds-averaged Navier-Stokes simulations using finite-volume solvers. We employ the higher-order spectral-element code Nek5000 to study the influence of numerical aspects on the prediction of the wind turbine wake structure and the wake interaction between two turbines. The spectral-element method enables an accurate representation of the vortical structures, with lower numerical dissipation than the more commonly used finite-volume codes. The wind-turbine blades are modeled as body forces using the actuator-line method (ACL) in the incompressible Navier-Stokes equations. Both tower and nacelle are represented with appropriate body forces. An inflow boundary condition is used which emulates homogeneous isotropic turbulence of wind-tunnel flows. We validate the implementation with results from experimental campaigns undertaken at the Norwegian University of Science and Technology (NTNU Blind Tests), investigate parametric influences and compare computational aspects with existing numerical simulations. In general the results show good agreement between the experiments and the numerical simulations both for a single-turbine setup as well as a two-turbine setup where the turbines are offset in the spanwise direction. A shift in the wake center caused by the tower wake is detected similar to experiments. The additional velocity deficit caused by the tower agrees well with the experimental data. The wake is captured well by Nek5000 in comparison with experiments both for the single wind turbine and in the two-turbine setup. The blade loading however shows large discrepancies for the high-turbulence, two-turbine case. While the experiments predicted higher thrust for the downstream turbine than for the upstream turbine, the opposite case was observed in Nek5000.

The articulation of integration of clinical and basic sciences in concept maps: differences between experienced and resident groups.

PubMed

Vink, Sylvia; van Tartwijk, Jan; Verloop, Nico; Gosselink, Manon; Driessen, Erik; Bolk, Jan

2016-08-01

To determine the content of integrated curricula, clinical concepts and the underlying basic science concepts need to be made explicit. Preconstructed concept maps are recommended for this purpose. They are mainly constructed by experts. However, concept maps constructed by residents are hypothesized to be less complex, to reveal more tacit basic science concepts and these basic science concepts are expected to be used for the organization of the maps. These hypotheses are derived from studies about knowledge development of individuals. However, integrated curricula require a high degree of cooperation between clinicians and basic scientists. This study examined whether there are consistent variations regarding the articulation of integration when groups of experienced clinicians and basic scientists and groups of residents and basic scientists-in-training construct concept maps. Seven groups of three clinicians and basic scientists on experienced level and seven such groups on resident level constructed concept maps illuminating clinical problems. They were guided by instructions that focused them on articulation of integration. The concept maps were analysed by features that described integration. Descriptive statistics showed consistent variations between the two expertise levels. The concept maps of the resident groups exceeded those of the experienced groups in articulated integration. First, they used significantly more links between clinical and basic science concepts. Second, these links connected basic science concepts with a greater variety of clinical concepts than the experienced groups. Third, although residents did not use significantly more basic science concepts, they used them significantly more frequent to organize the clinical concepts. The conclusion was drawn that not all hypotheses could be confirmed and that the resident concept maps were more elaborate than expected. This article discusses the implications for the role that residents and

Development of Predictive Wake Vortex Transport Model for Terminal Area Wake Vortex Avoidance

DOT National Transportation Integrated Search

1976-05-01

The wake vortex transport program has been expanded to include viscous effects and the influence of initial roll-up, atmospheric turbulence, and wind shear on the persistence and motion of wake vortices in terminal areas. Analysis of wake characteris...

Connectivity of Sleep- and Wake-Promoting Regions of the Human Hypothalamus During Resting Wakefulness.

PubMed

Boes, Aaron D; Fischer, David; Geerling, Joel C; Bruss, Joel; Saper, Clifford B; Fox, Michael D

2018-05-29

The hypothalamus is a central hub for regulating sleep-wake patterns, the circuitry of which has been investigated extensively in experimental animals. This work has identified a wake-promoting region in the posterior hypothalamus, with connections to other wake-promoting regions, and a sleep-promoting region in the anterior hypothalamus, with inhibitory projections to the posterior hypothalamus. It is unclear whether a similar organization exists in humans. Here, we use anatomical landmarks to identify homologous sleep and wake-promoting regions of the human hypothalamus and investigate their functional relationships using resting-state functional connectivity MRI in healthy awake participants. First, we identify a negative correlation (anticorrelation) between the anterior and posterior hypothalamus, two regions with opposing roles in sleep-wake regulation. Next, we show that hypothalamic connectivity predicts a pattern of regional sleep-wake changes previously observed in humans. Specifically, regions that are more positively correlated with the posterior hypothalamus and more negatively correlated with the anterior hypothalamus correspond to regions with the greatest change in cerebral blood flow between sleep-wake states. Taken together, these findings provide preliminary evidence relating a hypothalamic circuit investigated in animals to sleep-wake neuroimaging results in humans, with implications for our understanding of human sleep-wake regulation and the functional significance of anticorrelations.

Integrating basic science in academic cardiology training: two international perspectives on a common challenge.

PubMed

Bode, Michael F; Hilgendorf, Ingo

2018-06-09

Political bodies and professional societies acknowledge that translational research benefits from researchers trained in both, clinical medicine and basic science. Yet, few physicians undergoing clinical training in cardiology seek this dual career (Milewicz et al. J Clin Invest 125:3742-3747, 2015). The reasons are likely manifold, but with cardiology having become increasingly interventional and facing economic pressure, how much attention, credit, and encouragement is given to physicians interested in basic cardiovascular science? Having studied and worked in hospitals and laboratories, in both Germany and the USA, we aim to compare in this article how basic science education is currently integrated into cardiology training at German and US university hospitals, from medical school to more advanced career stages. By doing so, we hope to provide some outside perspectives to young physicians and decision makers alike, that may inspire changes to curricula in the respective countries and around the world.

Appraisal of ALM predictions of turbulent wake features

NASA Astrophysics Data System (ADS)

Rocchio, Benedetto; Cilurzo, Lorenzo; Ciri, Umberto; Salvetti, Maria Vittoria; Leonardi, Stefano

2017-11-01

Wind turbine blades create a turbulent wake that may persist far downstream, with significant implications on wind farm design and on its power production. The numerical representation of the real blade geometry would lead to simulations beyond the present computational resources. We focus our attention on the Actuator Line Model (ALM), in which the blade is replaced by a rotating line divided into finite segments with representative aerodynamic coefficients. The total aerodynamic force is projected along the computational axis and, to avoid numerical instabilities, it is distributed among the nearest grid points by using a Gaussian regularization kernel. The standard deviation of this kernel is a fundamental parameter that strongly affects the characteristics of the wake. We compare here the wake features obtained in direct numerical simulations of the flow around 2D bodies (a flat plate and an airfoil) modeled using the Immersed Boundary Method with the results of simulations in which the body is modeled by ALM. In particular, we investigate whether the ALM is able to reproduce the mean velocity field and the turbulent kinetic energy in the wake for the considered bodies at low and high angles of attack and how this depends on the choice of the ALM kernel. S. Leonardi was supported by the National Science Foundation, Grant No. 1243482 (the WINDINSPIRE project).

Hypersonic merged layer blunt body flows with wakes

NASA Technical Reports Server (NTRS)

Jain, Amolak C.; Dahm, Werner K.

1991-01-01

An attempt is made here to understand the basic physics of the flowfield with wake on a blunt body of revolution under hypersonic rarefied conditions. A merged layer model of flow is envisioned. Full steady-state Navier-Stokes equations in spherical polar coordinate system are computed from the surface with slip and temperature jump conditions to the free stream by the Accelerated Successive Replacement method of numerical integration. Analysis is developed for bodies of arbitrary shape, but actual computations have been carried out for a sphere and sphere-cone body. Particular attention is paid to set the limit of the onset of separation, wake closure, shear-layer impingement, formation and dissipation of the shocks in the flowfield. Validity of the results is established by comparing the present results for sphere with the corresponding results of the SOFIA code in the common region of their validity and with the experimental data.

Experimental evaluation of a flat wake theory for predicting rotor inflow-wake velocities

NASA Technical Reports Server (NTRS)

Wilson, John C.

1992-01-01

The theory for predicting helicopter inflow-wake velocities called flat wake theory was correlated with several sets of experimental data. The theory was developed by V. E. Baskin of the USSR, and a computer code known as DOWN was developed at Princeton University to implement the theory. The theory treats the wake geometry as rigid without interaction between induced velocities and wake structure. The wake structure is assumed to be a flat sheet of vorticity composed of trailing elements whose strength depends on the azimuthal and radial distributions of circulation on a rotor blade. The code predicts the three orthogonal components of flow velocity in the field surrounding the rotor. The predictions can be utilized in rotor performance and helicopter real-time flight-path simulation. The predictive capability of the coded version of flat wake theory provides vertical inflow patterns similar to experimental patterns.

Cystic fibrosis: Beyond the airways. Report on the meeting of the basic science working group in Loutraki, Greece.

PubMed

Amaral, Margarida D; Boj, Sylvia F; Shaw, James; Leipziger, Jens; Beekman, Jeffrey M

2018-06-01

The European Cystic Fibrosis Society (ECFS) Basic Science Working Group (BSWG) organized a session on the topic "Cystic Fibrosis: Beyond the Airways", within the 15th ECFS Basic Science Conference which gathered around 200 researchers working in the basic science of CF. The session was organized and chaired by Margarida Amaral (BioISI, University of Lisboa, Portugal) and Jeffrey Beekman (University Medical Centre Utrecht, Netherlands) as Chair and Vice-Chair of the BSWG and its purpose was to bring attention of participants of the ECFS Basic Science Conference to "more forgotten" organs in CF disease. In this report we attempt to review and integrate the ideas that emerged at the session. Copyright © 2018 European Cystic Fibrosis Society. All rights reserved.

The relationship between immediate relevant basic science knowledge and clinical knowledge: physiology knowledge and transthoracic echocardiography image interpretation.

PubMed

Nielsen, Dorte Guldbrand; Gotzsche, Ole; Sonne, Ole; Eika, Berit

2012-10-01

Two major views on the relationship between basic science knowledge and clinical knowledge stand out; the Two-world view seeing basic science and clinical science as two separate knowledge bases and the encapsulated knowledge view stating that basic science knowledge plays an overt role being encapsulated in the clinical knowledge. However, resent research has implied that a more complex relationship between the two knowledge bases exists. In this study, we explore the relationship between immediate relevant basic science (physiology) and clinical knowledge within a specific domain of medicine (echocardiography). Twenty eight medical students in their 3rd year and 45 physicians (15 interns, 15 cardiology residents and 15 cardiology consultants) took a multiple-choice test of physiology knowledge. The physicians also viewed images of a transthoracic echocardiography (TTE) examination and completed a checklist of possible pathologies found. A total score for each participant was calculated for the physiology test, and for all physicians also for the TTE checklist. Consultants scored significantly higher on the physiology test than did medical students and interns. A significant correlation between physiology test scores and TTE checklist scores was found for the cardiology residents only. Basic science knowledge of immediate relevance for daily clinical work expands with increased work experience within a specific domain. Consultants showed no relationship between physiology knowledge and TTE interpretation indicating that experts do not use basic science knowledge in routine daily practice, but knowledge of immediate relevance remains ready for use.

How do scientists respond to anomalies? Different strategies used in basic and applied science.

PubMed

Trickett, Susan Bell; Trafton, J Gregory; Schunn, Christian D

2009-10-01

We conducted two in vivo studies to explore how scientists respond to anomalies. Based on prior research, we identify three candidate strategies: mental simulation, mental manipulation of an image, and comparison between images. In Study 1, we compared experts in basic and applied domains (physics and meteorology). We found that the basic scientists used mental simulation to resolve an anomaly, whereas applied science practitioners mentally manipulated the image. In Study 2, we compared novice and expert meteorologists. We found that unlike experts, novices used comparison to address anomalies. We discuss the nature of expertise in the two kinds of science, the relationship between the type of science and the task performed, and the relationship of the strategies investigated to scientific creativity. Copyright © 2009 Cognitive Science Society, Inc.

Wake Vortex Research in the USA (WakeNet-USA)

NASA Technical Reports Server (NTRS)

Lang, Steve; Bryant, Wayne

2006-01-01

This viewgraph presentation reviews the cooperative work that FAA and NASA are engaged in to safely increase the capacity of the National Airspace System by studying the wake vortex operations. Wake vortex avoidance is a limiting factor in defining separation standards in the airport terminal area and could become a reducing separation standards in en route airspace.

A review of second law techniques applicable to basic thermal science research

NASA Astrophysics Data System (ADS)

Drost, M. Kevin; Zamorski, Joseph R.

1988-11-01

This paper reports the results of a review of second law analysis techniques which can contribute to basic research in the thermal sciences. The review demonstrated that second law analysis has a role in basic thermal science research. Unlike traditional techniques, second law analysis accurately identifies the sources and location of thermodynamic losses. This allows the development of innovative solutions to thermal science problems by directing research to the key technical issues. Two classes of second law techniques were identified as being particularly useful. First, system and component investigations can provide information of the source and nature of irreversibilities on a macroscopic scale. This information will help to identify new research topics and will support the evaluation of current research efforts. Second, the differential approach can provide information on the causes and spatial and temporal distribution of local irreversibilities. This information enhances the understanding of fluid mechanics, thermodynamics, and heat and mass transfer, and may suggest innovative methods for reducing irreversibilities.

Aircraft Wake RCS Measurement

NASA Technical Reports Server (NTRS)

Gilson, William H.

1994-01-01

A series of multi-frequency radar measurements of aircraft wakes at altitudes of 5,000 to 25,00 ft. were performed at Kwajalein, R.M.I., in May and June of 1990. Two aircraft were tested, a Learjet 35 and a Lockheed C-5A. The cross-section of the wake of the Learjet was too small for detection at Kwajalein. The wake of the C-5A, although also very small, was detected and measured at VHF, UHF, L-, S-, and C-bands, at distances behind the aircraft ranging from about one hundred meters to tens of kilometers. The data suggest that the mechanism by which aircraft wakes have detectable radar signatures is, contrary to previous expectations, unrelated to engine exhaust but instead due to turbulent mixing by the wake vortices of pre-existing index of refraction gradients in the ambient atmosphere. These measurements were of necessity performed with extremely powerful and sensitive instrumentation radars, and the wake cross-section is too small for most practical applications.

Aircraft wake RCS measurement

NASA Astrophysics Data System (ADS)

Gilson, William H.

1994-07-01

A series of multi-frequency radar measurements of aircraft wakes at altitudes of 5,000 to 25,00 ft. were performed at Kwajalein, R.M.I., in May and June of 1990. Two aircraft were tested, a Learjet 35 and a Lockheed C-5A. The cross-section of the wake of the Learjet was too small for detection at Kwajalein. The wake of the C-5A, although also very small, was detected and measured at VHF, UHF, L-, S-, and C-bands, at distances behind the aircraft ranging from about one hundred meters to tens of kilometers. The data suggest that the mechanism by which aircraft wakes have detectable radar signatures is, contrary to previous expectations, unrelated to engine exhaust but instead due to turbulent mixing by the wake vortices of pre-existing index of refraction gradients in the ambient atmosphere. These measurements were of necessity performed with extremely powerful and sensitive instrumentation radars, and the wake cross-section is too small for most practical applications.

Manipulating the sleep-wake cycle and circadian rhythms to improve clinical management of major depression

PubMed Central

2013-01-01

Background Clinical psychiatry has always been limited by the lack of objective tests to substantiate diagnoses and a lack of specific treatments that target underlying pathophysiology. One area in which these twin failures has been most frustrating is major depression. Due to very considerable progress in the basic and clinical neurosciences of sleep-wake cycles and underlying circadian systems this situation is now rapidly changing. Discussion The development of specific behavioral or pharmacological strategies that target these basic regulatory systems is driving renewed clinical interest. Here, we explore the extent to which objective tests of sleep-wake cycles and circadian function - namely, those that measure timing or synchrony of circadian-dependent physiology as well as daytime activity and nighttime sleep patterns - can be used to identify a sub-class of patients with major depression who have disturbed circadian profiles. Summary Once this unique pathophysiology is characterized, a highly personalized treatment plan can be proposed and monitored. New treatments will now be designed and old treatments re-evaluated on the basis of their effects on objective measures of sleep-wake cycles, circadian rhythms and related metabolic systems. PMID:23521808

Wake flowfields for Jovian probe

NASA Technical Reports Server (NTRS)

Engel, C. D.; Hair, L. M.

1980-01-01

The wake flow field developed by the Galileo probe as it enters the Jovian atmosphere was modeled. The wake produced by the probe is highly energetic, yielding both convective and radiative heat inputs to the base of the probe. A component mathematical model for the inviscid near and far wake, the viscous near and far wake, and near wake recirculation zone was developed. Equilibrium thermodynamics were used for both the ablation and atmospheric species. Flow fields for three entry conditions were calculated. The near viscous wave was found to exhibit a variable axial pressure distribution with the neck pressure approximately three times the base pressure. Peak wake flow field temperatures were found to be in proportion to forebody post shock temperatures.

Pima College Students' Knowledge of Selected Basic Physical Science Concepts.

ERIC Educational Resources Information Center

Iadevaia, David G.

In 1989 a study was conducted at Pima Community College (PCC) to assess students' knowledge of basic physical science concepts. A three-part survey instrument was administered to students in a second semester sociology class, a first semester astronomy class, a second semester Spanish class, and a first semester physics class. The survey…

The Sequencing of Basic Chemistry Topics by Physical Science Teachers

ERIC Educational Resources Information Center

Sibanda, Doras; Hobden, Paul

2016-01-01

The purpose of this study was to find out teachers' preferred teaching sequence for basic chemistry topics in Physical Science in South Africa, to obtain their reasons underpinning their preferred sequence, and to compare these sequences with the prescribed sequences in the current curriculum. The study was located within a pragmatic paradigm and…

Improved knowledge gain and retention for third-year medical students during surgical journal club using basic science review: A pilot study.

PubMed

Williams, Austin D; Mann, Barry D

2017-02-01

As they enter the clinical years, medical students face large adjustments in the acquisition of medical knowledge. We hypothesized that basic science review related to the topic of journal club papers would increase the educational benefit for third-year medical students. Students were randomized either to participation in a review session about basic science related to the journal club paper, or to no review. After one day, and after three months, students were given a 10-question quiz encompassing the basic science and the clinical implications of the paper. Twenty-six of 50 students were randomized to basic science review. These students scored better on both sections of the quiz one day after journal club, but only on basic science questions after three months. Students who participated in basic science review had better knowledge gain and retention. Educational activities building upon foundational knowledge improves learning on clinical rotations. Copyright © 2016 Elsevier Inc. All rights reserved.

Development and Validation of a Project Package for Junior Secondary School Basic Science

ERIC Educational Resources Information Center

Udofia, Nsikak-Abasi

2014-01-01

This was a Research and Developmental study designed to develop and validate projects for Junior Secondary School Basic Science instruction and evaluation. The projects were developed using the project blueprint and sent for validation by experts in science education and measurement and evaluation; using a project validation scale. They were to…

Self-preservation of turbulent wakes

NASA Technical Reports Server (NTRS)

Mehta, Jayesh M.

1989-01-01

The present experiment has ascertained the development of the wake flow behind NASA GA(W)-1 airfoils, showing that, in the far wake, the mean velocity profiles exhibit self-similar behavior irrespective of the upstream boundary layer's character. It is noted, however, that the processes by means of which different wakes reach the asymptotic stage can be very different for different types of wake generators.

Conference on Capacity and Wake Vortices Held in Imperial College of Science, London on 11-14 September 2001. Abstracts of Presentations

NASA Technical Reports Server (NTRS)

Whitelaw, J. H.

2001-01-01

Partial Contents: The Effect of Aircraft Wake Vortex Separation on Air Transportation Capacity; The Pilots View of Wake Vortices - Capacity vs. Safety; Runway Capacity Constraints at Heathrow Airport; FAA's Research Strategy; Increasing Capacity by Wake Turbulence Avoidance Systems at Frankfurt/Main Airport; Improving Airport Capacity Using Vertical Flight; Recent Developments in Industrial Wake Vortex Research; Vortex Evolution and Characterization; PIV -Survey of the Vortex Wake Structure behind an Airbus A340 in a Towing Tank.

Integrating Basic Science and Clinical Teaching for Third-Year Medical Students.

ERIC Educational Resources Information Center

Croen, Lila G.; And Others

1986-01-01

A 2-month program for third-year students at Yeshiva's Albert Einstein College of Medicine that provides a model for integrating basic sciences and clinical training is described. It demonstrates the importance of lifelong learning in a field that constantly changes. (Author/MLW)

Utilization and acceptance of virtual patients in veterinary basic sciences - the vetVIP-project.

PubMed

Kleinsorgen, Christin; Kankofer, Marta; Gradzki, Zbigniew; Mandoki, Mira; Bartha, Tibor; von Köckritz-Blickwede, Maren; Naim, Hassan Y; Beyerbach, Martin; Tipold, Andrea; Ehlers, Jan P

2017-01-01

Context: In medical and veterinary medical education the use of problem-based and cased-based learning has steadily increased over time. At veterinary faculties, this development has mainly been evident in the clinical phase of the veterinary education. Therefore, a consortium of teachers of biochemistry and physiology together with technical and didactical experts launched the EU-funded project "vetVIP", to create and implement veterinary virtual patients and problems for basic science instruction. In this study the implementation and utilization of virtual patients occurred at the veterinary faculties in Budapest, Hannover and Lublin. Methods: This report describes the investigation of the utilization and acceptance of students studying veterinary basic sciences using optional online learning material concurrently to regular biochemistry and physiology didactic instruction. The reaction of students towards this offer of clinical case-based learning in basic sciences was analysed using quantitative and qualitative data. Quantitative data were collected automatically within the chosen software-system CASUS as user-log-files. Responses regarding the quality of the virtual patients were obtained using an online questionnaire. Furthermore, subjective evaluation by authors was performed using a focus group discussion and an online questionnaire. Results: Implementation as well as usage and acceptance varied between the three participating locations. High approval was documented in Hannover and Lublin based upon the high proportion of voluntary students (>70%) using optional virtual patients. However, in Budapest the participation rate was below 1%. Due to utilization, students seem to prefer virtual patients and problems created in their native language and developed at their own university. In addition, the statement that assessment drives learning was supported by the observation that peak utilization was just prior to summative examinations. Conclusion: Veterinary

Vertical integration of basic science in final year of medical education.

PubMed

Rajan, Sudha Jasmine; Jacob, Tripti Meriel; Sathyendra, Sowmya

2016-01-01

Development of health professionals with ability to integrate, synthesize, and apply knowledge gained through medical college is greatly hampered by the system of delivery that is compartmentalized and piecemeal. There is a need to integrate basic sciences with clinical teaching to enable application in clinical care. To study the benefit and acceptance of vertical integration of basic science in final year MBBS undergraduate curriculum. After Institutional Ethics Clearance, neuroanatomy refresher classes with clinical application to neurological diseases were held as part of the final year posting in two medical units. Feedback was collected. Pre- and post-tests which tested application and synthesis were conducted. Summative assessment was compared with the control group of students who had standard teaching in other two medical units. In-depth interview was conducted on 2 willing participants and 2 teachers who did neurology bedside teaching. Majority (>80%) found the classes useful and interesting. There was statistically significant improvement in the post-test scores. There was a statistically significant difference between the intervention and control groups' scores during summative assessment (76.2 vs. 61.8 P < 0.01). Students felt that it reinforced, motivated self-directed learning, enabled correlations, improved understanding, put things in perspective, gave confidence, aided application, and enabled them to follow discussions during clinical teaching. Vertical integration of basic science in final year was beneficial and resulted in knowledge gain and improved summative scores. The classes were found to be useful, interesting and thought to help in clinical care and application by majority of students.

Vertical integration of basic science in final year of medical education

PubMed Central

Rajan, Sudha Jasmine; Jacob, Tripti Meriel; Sathyendra, Sowmya

2016-01-01

Background: Development of health professionals with ability to integrate, synthesize, and apply knowledge gained through medical college is greatly hampered by the system of delivery that is compartmentalized and piecemeal. There is a need to integrate basic sciences with clinical teaching to enable application in clinical care. Aim: To study the benefit and acceptance of vertical integration of basic science in final year MBBS undergraduate curriculum. Materials and Methods: After Institutional Ethics Clearance, neuroanatomy refresher classes with clinical application to neurological diseases were held as part of the final year posting in two medical units. Feedback was collected. Pre- and post-tests which tested application and synthesis were conducted. Summative assessment was compared with the control group of students who had standard teaching in other two medical units. In-depth interview was conducted on 2 willing participants and 2 teachers who did neurology bedside teaching. Results: Majority (>80%) found the classes useful and interesting. There was statistically significant improvement in the post-test scores. There was a statistically significant difference between the intervention and control groups' scores during summative assessment (76.2 vs. 61.8 P < 0.01). Students felt that it reinforced, motivated self-directed learning, enabled correlations, improved understanding, put things in perspective, gave confidence, aided application, and enabled them to follow discussions during clinical teaching. Conclusion: Vertical integration of basic science in final year was beneficial and resulted in knowledge gain and improved summative scores. The classes were found to be useful, interesting and thought to help in clinical care and application by majority of students. PMID:27563584

Evaluation of Some Approved Basic Science and Technology Textbooks in Use in Junior Secondary Schools in Nigeria

ERIC Educational Resources Information Center

Nwafor, C. E.; Umoke, C. C.

2016-01-01

This study was designed to evaluate the content adequacy and readability of approved basic science and technology textbooks in use in junior secondary schools in Nigeria. Eight research questions guided the study. The sample of the study consisted of six (6) approved basic science and technology textbooks, 30 Junior Secondary Schools randomly…

Long-Term Retention of Basic Science Knowledge: A Review Study

ERIC Educational Resources Information Center

Custers, Eugene J. F. M.

2010-01-01

In this paper, a review of long-term retention of basic science knowledge is presented. First, it is argued that retention of this knowledge has been a long-standing problem in medical education. Next, three types of studies are described that are employed in the literature to investigate long-term retention of knowledge in general. Subsequently,…

The Challenge of the Humanities and Social Science Education Through the Basic Seminar (Science of Snow Sports)

NASA Astrophysics Data System (ADS)

Taniai, Tetsuyuki; Sugimoto, Taku; Sato, Ken-Ichi; Ikota, Masaru

The Education Center of Chiba Institute of Technology is taking a new approach to the introduction of liberal arts subjects commonly included in the curriculum of all departments through a newly established basic seminar, the Science of Snow Sports. Each faculty member has been working on setting up classes that cross the conventional boundaries of fields and disciplines and which are targeted at students of all faculties and departments. This paper describes the potential for teaching liberal arts and social science subjects to engineering students through the medium of sports science, based on actual experience gained via this new approach.

Café Científico and Wake up with science. Really fun and interesting outreach activities

NASA Astrophysics Data System (ADS)

Farrona, A. M. M.; Vilar, R.

2016-04-01

;Café Científico; is a series of informal discussions connecting research and society. This outreach activity allows people enjoy while engaging with cutting-edge researchers from University of Cantabria. In Santander, since July 2012, we have a meeting on the last Friday of the month, in the ;Café de las Artes;, a special theatre at the city. At the same time, we carry out the same activity only for children: ;Wake up with Science;. Once in a month, usually the third Thursday of every month, at the University, we invite children to participate in a special ;Café Científico; only for the youngest. With this contribution we want to present a successful outreach activity, with two versions, adapted for participants aged. In any case, these activities always attract many people from Cantabria.

PREFACE: Wake Conference 2015

NASA Astrophysics Data System (ADS)

Barney, Andrew; Nørkær Sørensen, Jens; Ivanell, Stefan

2015-06-01

The 44 papers in this volume constitute the proceedings of the 2015 Wake Conference, held in Visby on the island of Gotland in Sweden. It is the fourth time this conference has been held. The Wake Conference series started in Visby, where it was held in 2009 and 2011. In 2013 it took place in Copenhagen where it was combined with the International Conference on Offshore Wind Energy and Ocean Energy. In 2015 it is back where it started in Visby, where it takes place at Uppsala University Campus Gotland, June 9th-11th. The global yearly production of electrical energy by wind turbines has grown tremendously in the past decade and it now comprises more than 3% of the global electrical power consumption. Today the wind power industry has a global annual turnover of more than 50 billion USD and an annual average growth rate of more than 20%. State-of-the-art wind turbines have rotor diameters of up to 150 m and 8 MW installed capacity. These turbines are often placed in large wind farms that have a total production capacity corresponding to that of a nuclear power plant. In order to make a substantial impact on one of the most significant challenges of our time, global warming, the industry's growth has to continue for a decade or two yet. This in turn requires research into the physics of wind turbine wakes and wind farms. Modern wind turbines are today clustered in wind farms in which the turbines are fully or partially influenced by the wake of upstream turbines. As a consequence, the wake behind the wind turbines has a lower mean wind speed and an increased turbulence level, as compared to the undisturbed flow outside the farm. Hence, wake interaction results in decreased total production of power, caused by lower kinetic energy in the wind, and an increase in the turbulence intensity. Therefore, understanding the physical nature of the vortices and their dynamics in the wake of a turbine is important for the optimal design of a wind farm. This conference is aimed

Circadian Rhythm Sleep-Wake Disorders.

PubMed

Pavlova, Milena

2017-08-01

The endogenous circadian rhythms are one of the cardinal processes that control sleep. They are self-sustaining biological rhythms with a periodicity of approximately 24 hours that may be entrained by external zeitgebers (German for time givers), such as light, exercise, and meal times. This article discusses the physiology of the circadian rhythms, their relationship to neurologic disease, and the presentation and treatment of circadian rhythm sleep-wake disorders. Classic examples of circadian rhythms include cortisol and melatonin secretion, body temperature, and urine volume. More recently, the impact of circadian rhythm on several neurologic disorders has been investigated, such as the timing of occurrence of epileptic seizures as well as neurobehavioral functioning in dementia. Further updates include a more in-depth understanding of the symptoms, consequences, and treatment of circadian sleep-wake disorders, which may occur because of extrinsic misalignment with clock time or because of intrinsic dysfunction of the brain. An example of extrinsic misalignment occurs with jet lag during transmeridian travel or with intrinsic circadian rhythm sleep-wake disorders such as advanced or delayed sleep-wake phase disorders. In advanced sleep-wake phase disorder, which is most common in elderly individuals, sleep onset and morning arousal are undesirably early, leading to impaired evening function with excessive sleepiness and sleep-maintenance insomnia with early morning awakening. By contrast, delayed sleep-wake phase disorder is characterized by an inability to initiate sleep before the early morning hours, with subsequent delayed rise time, leading to clinical symptoms of severe sleep-onset insomnia coupled with excessive daytime sleepiness in the morning hours, as patients are unable to "sleep in" to attain sufficient sleep quantity. Irregular sleep-wake rhythm disorder is misentrainment with patches of brief sleep and wakefulness spread throughout the day

Basic Science.

ERIC Educational Resources Information Center

Mercer County Community Coll., Trenton, NJ.

Instructional materials are provided for a course that covers basic concepts of physics and chemistry. Designed for use in a workplace literacy project developed by Mercer County Community College (New Jersey) and its partners, the course describes applications of these concepts to real-life situations, with an emphasis on applications of…

The Impact of Hands-On-Approach on Student Academic Performance in Basic Science and Mathematics

ERIC Educational Resources Information Center

Ekwueme, Cecilia O.; Ekon, Esther E.; Ezenwa-Nebife, Dorothy C.

2015-01-01

Children can learn mathematics and sciences effectively even before being exposed to formal school curriculum if basic Mathematics and Sciences concepts are communicated to them early using activity oriented (Hands-on) method of teaching. Mathematics and Science are practical and activity oriented and can best be learnt through inquiry (Okebukola…

Pair Comparison Study of the Relevance of Nine Basic Science Courses

ERIC Educational Resources Information Center

Spilman, Edra L.; Spilman, Helen W.

1975-01-01

Reports a survey study in which basic science courses were rated according to relevance. Notes approaches for making the anatomy disciplines more relevant because results showed them of lowest relevancy compared with physiology, pathology, and pharmacology which were rated of highest relevance and with biochemistry and microbiology which fell…

ASRS Reports on Wake Vortex Encounters

NASA Technical Reports Server (NTRS)

Connell, Linda J.; Taube, Elisa Ann; Drew, Charles Robert; Barclay, Tommy Earl

2010-01-01

ASRS is conducting a structured callback research project of wake vortex incidents reported to the ASRS at all US airports, as well as wake encounters in the enroute environment. This study has three objectives: (1) Utilize the established ASRS supplemental data collection methodology and provide ongoing analysis of wake vortex encounter reports; (2) Document event dynamics and contributing factors underlying wake vortex encounter events; and (3) Support ongoing FAA efforts to address pre-emptive wake vortex risk reduction by utilizing ASRS reporting contributions.

The Neuropsychoanalytic Approach: Using Neuroscience as the Basic Science of Psychoanalysis.

PubMed

Johnson, Brian; Flores Mosri, Daniela

2016-01-01

Neuroscience was the basic science behind Freud's psychoanalytic theory and technique. He worked as a neurologist for 20 years before being aware that a new approach to understand complex diseases, namely the hysterias, was needed. Solms coined the term neuropsychoanalysis to affirm that neuroscience still belongs in psychoanalysis. The neuropsychoanalytic field has continued Freud's original ideas as stated in 1895. Developments in psychoanalysis that have been created or revised by the neuropsychoanalysis movement include pain/relatedness/opioids, drive, structural model, dreams, cathexis, and dynamic unconscious. Neuroscience has contributed to the development of new psychoanalytic theory, such as Bazan's (2011) description of anxiety driven by unconscious intentions or "phantoms." Results of adopting the "dual aspect monism" approach of idiographic psychoanalytic clinical observation combined with nomothetic investigation of related human phenomena include clarification and revision of theory, restoration of the scientific base of psychoanalysis, and improvement of clinical treatments. By imbricating psychoanalytic thinking with neuroscience, psychoanalysts are also positioned to make contributions to neuroscience research. Freud's original Project for a Scientific Psychology/Psychology for Neurologists can be carried forward in a way that moves psychoanalysis into the twenty-first century as a core contemporary science (Kandel, 1999). Neuroscience as the basic science of psychoanalysis both improves the field, and enhances its scientific and cultural status.

Basic Energy Sciences Program Update

DOE Office of Scientific and Technical Information (OSTI.GOV)

None, None

2016-01-04

The U.S. Department of Energy’s (DOE) Office of Basic Energy Sciences (BES) supports fundamental research to understand, predict, and ultimately control matter and energy at the electronic, atomic, and molecular levels to provide the foundations for new energy technologies and to support DOE missions in energy, environment, and national security. The research disciplines covered by BES—condensed matter and materials physics, chemistry, geosciences, and aspects of physical biosciences— are those that discover new materials and design new chemical processes. These disciplines touch virtually every aspect of energy resources, production, conversion, transmission, storage, efficiency, and waste mitigation. BES also plans, constructs, andmore » operates world-class scientific user facilities that provide outstanding capabilities for imaging and spectroscopy, characterizing materials of all kinds ranging from hard metals to fragile biological samples, and studying the chemical transformation of matter. These facilities are used to correlate the microscopic structure of materials with their macroscopic properties and to study chemical processes. Such experiments provide critical insights to electronic, atomic, and molecular configurations, often at ultrasmall length and ultrafast time scales.« less

Improving College Faculty Instruction in the Basic and Allied Health Sciences.

ERIC Educational Resources Information Center

Washton, Nathan S.

A project to improve college instruction in the basic and allied health sciences at New York Chiropractic College and the New York Institute of Technology is described. Attention was directed to: the kinds of resources colleges and professional schools provide to improve instruction; motivation of faculty to explore innovative or strategic…

Medical Student Use of Objectives in Basic Science and Clinical Instruction.

ERIC Educational Resources Information Center

And Others; Mast, Terrill A.

1980-01-01

A study that investigated the long-term use of instructional objectives by medical students taking basic science and clinical courses is reported. Focus is on the extent and manner in which the objectives were used and factors that influenced their use. Students reported heavier usage earlier in the curriculum. (Author/JMD)

Basic Science Evidence for the Link Between Erectile Dysfunction and Cardiometabolic Dysfunction

PubMed Central

Musicki, Biljana; Bella, Anthony J.; Bivalacqua, Trinity J.; Davies, Kelvin P.; DiSanto, Michael E.; Gonzalez-Cadavid, Nestor F.; Hannan, Johanna L.; Kim, Noel N.; Podlasek, Carol A.; Wingard, Christopher J.; Burnett, Arthur L.

2016-01-01

Introduction Although clinical evidence supports an association between cardiovascular/metabolic diseases (CVMD) and erectile dysfunction (ED), scientific evidence for this link is incompletely elucidated. Aim This study aims to provide scientific evidence for the link between CVMD and ED. Methods In this White Paper, the Basic Science Committee of the Sexual Medicine Society of North America assessed the current literature on basic scientific support for a mechanistic link between ED and CVMD, and deficiencies in this regard with a critical assessment of current preclinical models of disease. Results A link exists between ED and CVMD on several grounds: the endothelium (endothelium-derived nitric oxide and oxidative stress imbalance); smooth muscle (SM) (SM abundance and altered molecular regulation of SM contractility); autonomic innervation (autonomic neuropathy and decreased neuronal-derived nitric oxide); hormones (impaired testosterone release and actions); and metabolics (hyperlipidemia, advanced glycation end product formation). Conclusion Basic science evidence supports the link between ED and CVMD. The Committee also highlighted gaps in knowledge and provided recommendations for guiding further scientific study defining this risk relationship. This endeavor serves to develop novel strategic directions for therapeutic interventions. PMID:26646025

The Basic Science Curriculum in the 21st Century: What Needs to Be Changed?

ERIC Educational Resources Information Center

Garant, Philias R.

1986-01-01

The basic science curriculum in dental education could be improved by adopting a curriculum containing only two integrated required science courses about (1) the structure and function of the human body and (2) disease and reaction to disease in the human body. Elective graduate-level predoctoral courses would allow specialization. (MSE)

Helicopter rotor wake geometry and its influence in forward flight. Volume 1: Generalized wake geometry and wake effect on rotor airloads and performance

NASA Technical Reports Server (NTRS)

Egolf, T. A.; Landgrebe, A. J.

1983-01-01

An analytic investigation to generalize wake geometry of a helicopter rotor in steady level forward flight and to demonstrate the influence of wake deformation in the prediction of rotor airloads and performance is described. Volume 1 presents a first level generalized wake model based on theoretically predicted tip vortex geometries for a selected representative blade design. The tip vortex distortions are generalized in equation form as displacements from the classical undistorted tip vortex geometry in terms of vortex age, blade azimuth, rotor advance ratio, thrust coefficient, and number of blades. These equations were programmed to provide distorted wake coordinates at very low cost for use in rotor airflow and airloads prediction analyses. The sensitivity of predicted rotor airloads, performance, and blade bending moments to the modeling of the tip vortex distortion are demonstrated for low to moderately high advance ratios for a representative rotor and the H-34 rotor. Comparisons with H-34 rotor test data demonstrate the effects of the classical, predicted distorted, and the newly developed generalized wake models on airloads and blade bending moments. Use of distorted wake models results in the occurrence of numerous blade-vortex interactions on the forward and lateral sides of the rotor disk. The significance of these interactions is related to the number and degree of proximity to the blades of the tip vortices. The correlation obtained with the distorted wake models (generalized and predicted) is encouraging.

Basic Research in the Mission Agencies: Agency Perspectives on the Conduct and Support of Basic Research. Report of the National Science Board, 1978.

ERIC Educational Resources Information Center

National Science Foundation, Washington, DC. National Science Board.

A survey was conducted by the National Science Board of the basic research supported by executive branch agencies of the federal government. Most of the data came from information solicited by the Board from federal agencies involved in science. Fourteen mission agencies and two agencies not so classified and 20 subunits of these responded.…

THE DEVELOPMENT OF SLEEP-WAKE RHYTHMS AND THE SEARCH FOR ELEMENTAL CIRCUITS IN THE INFANT BRAIN

PubMed Central

Blumberg, Mark S.; Gall, Andrew J.; Todd, William D.

2014-01-01

Despite the predominance of sleep in early infancy, developmental science has yet to play a major role in shaping concepts and theories about sleep and its associated ultradian and circadian rhythms. Here we argue that developmental analyses help us to elucidate the relative contributions of the brainstem and forebrain to sleep-wake control and to dissect the neural components of sleep-wake rhythms. Developmental analysis also makes it clear that sleep-wake processes in infants are the foundation for those of adults. For example, the infant brainstem alone contains a fundamental sleep-wake circuit that is sufficient to produce transitions among wakefulness, quiet sleep, and active sleep. Also, consistent with the requirements of a “flip-flop” model of sleep-wake processes, this brainstem circuit supports rapid transitions between states. Later in development, strengthening bidirectional interactions between the brainstem and forebrain contribute to the consolidation of sleep and wake bouts, the elaboration of sleep homeostatic processes, and the emergence of diurnal or nocturnal circadian rhythms. The developmental perspective promoted here critically constrains theories of sleep-wake control and provides a needed framework for the creation of fully realized computational models. Finally, with a better understanding of how this system is constructed developmentally, we will gain insight into the processes that govern its disintegration due to aging and disease. PMID:24708298

The development of sleep-wake rhythms and the search for elemental circuits in the infant brain.

PubMed

Blumberg, Mark S; Gall, Andrew J; Todd, William D

2014-06-01

Despite the predominance of sleep in early infancy, developmental science has yet to play a major role in shaping concepts and theories about sleep and its associated ultradian and circadian rhythms. Here we argue that developmental analyses help us to elucidate the relative contributions of the brainstem and forebrain to sleep-wake control and to dissect the neural components of sleep-wake rhythms. Developmental analysis also makes it clear that sleep-wake processes in infants are the foundation for those of adults. For example, the infant brainstem alone contains a fundamental sleep-wake circuit that is sufficient to produce transitions among wakefulness, quiet sleep, and active sleep. In addition, consistent with the requirements of a "flip-flop" model of sleep-wake processes, this brainstem circuit supports rapid transitions between states. Later in development, strengthening bidirectional interactions between the brainstem and forebrain contribute to the consolidation of sleep and wake bouts, the elaboration of sleep homeostatic processes, and the emergence of diurnal or nocturnal circadian rhythms. The developmental perspective promoted here critically constrains theories of sleep-wake control and provides a needed framework for the creation of fully realized computational models. Finally, with a better understanding of how this system is constructed developmentally, we will gain insight into the processes that govern its disintegration due to aging and disease.

Asymptotic expansions for 2D symmetrical laminar wakes

NASA Astrophysics Data System (ADS)

Belan, Marco; Tordella, Daniela

1999-11-01

An extension of the well known asymptotic representation of the 2D laminar incompressible wake past a symmetrical body is presented. Using the thin free shear layer approximation we determined solutions in terms of infinite asymptotic expansions. These are power series of the streamwise space variable with fractional negative coefficients. The general n-th order term has been analytically established. Through analysis of the behaviour of the same expansions inserted into the Navier-Stokes equations, we verified the self-consistency of the approximation showing that at the third order the correction due to pressure variations identically vanishes while the contribution of the longitudinal diffusion is still two-three order of magnitude smaller than that of the transversal diffusion, depending on Re. When the procedure is applied to the Navier-Stokes equations, we showed that further mathematical difficulties do not arise. Where opportune one may thus easily shift to the complete model. Through a spatial multiscaling approach, a brief account on the stability properties of these expansions as representing the non parallel basic flow of 2D wakes will be given.

Dynamic wake prediction and visualization with uncertainty analysis

NASA Technical Reports Server (NTRS)

Holforty, Wendy L. (Inventor); Powell, J. David (Inventor)

2005-01-01

A dynamic wake avoidance system utilizes aircraft and atmospheric parameters readily available in flight to model and predict airborne wake vortices in real time. A novel combination of algorithms allows for a relatively simple yet robust wake model to be constructed based on information extracted from a broadcast. The system predicts the location and movement of the wake based on the nominal wake model and correspondingly performs an uncertainty analysis on the wake model to determine a wake hazard zone (no fly zone), which comprises a plurality of wake planes, each moving independently from another. The system selectively adjusts dimensions of each wake plane to minimize spatial and temporal uncertainty, thereby ensuring that the actual wake is within the wake hazard zone. The predicted wake hazard zone is communicated in real time directly to a user via a realistic visual representation. In an example, the wake hazard zone is visualized on a 3-D flight deck display to enable a pilot to visualize or see a neighboring aircraft as well as its wake. The system substantially enhances the pilot's situational awareness and allows for a further safe decrease in spacing, which could alleviate airport and airspace congestion.

A case-based, small-group cooperative learning course in preclinical veterinary science aimed at bridging basic science and clinical literacy.

PubMed

Schoeman, J P; van Schoor, M; van der Merwe, L L; Meintjes, R A

2009-03-01

In 1999 a dedicated problem-based learning course was introduced into the lecture-based preclinical veterinary curriculum of the University of Pretoria. The Introduction to Clinical Studies Course combines traditional lectures, practical sessions, student self-learning and guided tutorials. The self-directed component of the course utilises case-based, small-group cooperative learning as an educational vehicle to link basic science with clinical medicine. The aim of this article is to describe the objectives and structure of the course and to report the results of the assessment of the students' perceptions on some aspects of the course. Students reacted very positively to the ability of the course to equip them with problem-solving skills. Students indicated positive perceptions about the workload of the course. There were, however, significantly lower scores for the clarity of the course objectives. Although the study guide for the course is very comprehensive, the practice regarding the objectives is still uncertain. It is imperative to set clear objectives in non-traditional, student-centred courses. The objectives have to be explained at the outset and reiterated throughout the course. Tutors should also communicate the rationale behind problem-based learning as a pedagogical method to the students. Further research is needed to verify the effectiveness of this course in bridging the gap between basic science and clinical literacy in veterinary science. Ongoing feedback and assessment of the management and content are important to refine this model for integrating basic science with clinical literacy.

Thinking science with thinking machines: The multiple realities of basic and applied knowledge in a research border zone.

PubMed

Hoffman, Steve G

2015-04-01

Some scholars dismiss the distinction between basic and applied science as passé, yet substantive assumptions about this boundary remain obdurate in research policy, popular rhetoric, the sociology and philosophy of science, and, indeed, at the level of bench practice. In this article, I draw on a multiple ontology framework to provide a more stable affirmation of a constructivist position in science and technology studies that cannot be reduced to a matter of competing perspectives on a single reality. The analysis is grounded in ethnographic research in the border zone of Artificial Intelligence science. I translate in-situ moments in which members of neighboring but differently situated labs engage in three distinct repertoires that render the reality of basic and applied science: partitioning, flipping, and collapsing. While the essences of scientific objects are nowhere to be found, the boundary between basic and applied is neither illusion nor mere propaganda. Instead, distinctions among scientific knowledge are made real as a matter of course.

Application of basic science to clinical problems: traditional vs. hybrid problem-based learning.

PubMed

Callis, Amber N; McCann, Ann L; Schneiderman, Emet D; Babler, William J; Lacy, Ernestine S; Hale, David Sidney

2010-10-01

It is widely acknowledged that clinical problem-solving is a key skill for dental practitioners. The aim of this study was to determine if students in a hybrid problem-based learning curriculum (h-PBL) were better at integrating basic science knowledge with clinical cases than students in a traditional, lecture-based curriculum (TC). The performance of TC students (n=40) was compared to that of h-PBL students (n=31). Participants read two clinical scenarios and answered a series of questions regarding each. To control for differences in ability, Dental Admission Test (DAT) Academic Average scores and predental grade point averages (GPAs) were compared, and an ANCOVA was used to adjust for the significant differences in DAT (t-test, p=0.002). Results showed that h-PBL students were better at applying basic science knowledge to a clinical case (ANCOVA, p=0.022) based on overall scores on one case. TC students' overall scores were better than h-PBL students on a separate case; however, it was not statistically significant (p=0.107). The h-PBL students also demonstrated greater skills in the areas of hypothesis generation (Mann-Whitney U, p=0.016) and communication (p=0.006). Basic science comprehension (p=0.01) and neurology (p<0.001) were two areas in which the TC students did score significantly higher than h-PBL students.

Wake Turbulence Training Aid.

DOT National Transportation Integrated Search

1995-04-01

The goal of the Wake Turbulence Training Aid is to reduce the number of wake-turbulence related accidents and incidents by improving the pilot's and air traffic controller's decision making and situational awareness through increased and shared under...

Dynamic Hybrid Simulation of the Lunar Wake During ARTEMIS Crossing

NASA Astrophysics Data System (ADS)

Wiehle, S.; Plaschke, F.; Angelopoulos, V.; Auster, H.; Glassmeier, K.; Kriegel, H.; Motschmann, U. M.; Mueller, J.

2010-12-01

The interaction of the highly dynamic solar wind with the Moon is simulated with the A.I.K.E.F. (Adaptive Ion Kinetic Electron Fluid) code for the ARTEMIS P1 flyby on February 13, 2010. The A.I.K.E.F. hybrid plasma simulation code is the improved version of the Braunschweig code. It is able to automatically increase simulation grid resolution in areas of interest during runtime, which greatly increases resolution as well as performance. As the Moon has no intrinsic magnetic field and no ionosphere, the solar wind particles are absorbed at its surface, resulting in the formation of the lunar wake at the nightside. The solar wind magnetic field is basically convected through the Moon and the wake is slowly filled up with solar wind particles. However, this interaction is strongly influenced by the highly dynamic solar wind during the flyby. This is considered by a dynamic variation of the upstream conditions in the simulation using OMNI solar wind measurement data. By this method, a very good agreement between simulation and observations is achieved. The simulations show that the stationary structure of the lunar wake constitutes a tableau vivant in space representing the well-known Friedrichs diagram for MHD waves.

Basic Science Research and the Protection of Human Research Participants

NASA Astrophysics Data System (ADS)

Eiseman, Elisa

2001-03-01

Technological advances in basic biological research have been instrumental in recent biomedical discoveries, such as in the understanding and treatment of cancer, HIV/AIDS, and heart disease. However, many of these advances also raise several new ethical challenges. For example, genetic research may pose no physical risk beyond that of obtaining the initial blood sample, yet it can pose significant psychological and economic risks to research participants, such as stigmatization, discrimination in insurance and employment, invasion of privacy, or breach of confidentiality. These harms may occur even when investigators do not directly interact with the person whose DNA they are studying. Moreover, this type of basic research also raises broader questions, such as what is the definition of a human subject, and what kinds of expertise do Institutional Review Boards (IRBs) need to review the increasingly diverse types of research made possible by these advances in technology. The National Bioethics Advisory Commission (NBAC), a presidentially appointed federal advisory committee, has addressed these and other ethical, scientific and policy issues that arise in basic science research involving human participants. Two of its six reports, in particular, have proposed recommendations in this regard. "Research Involving Human Biological Materials: Ethical and Policy Guidance" addresses the basic research use of human tissues, cells and DNA and the protection of human participants in this type of research. In "Ethical and Policy Issues in the Oversight of Human Research" NBAC proposes a definition of research involving human participants that would apply to all scientific disciplines, including physical, biological, and social sciences, as well as the humanities and related professions, such as business and law. Both of these reports make it clear that the protection of research participants is key to conducting ethically sound research. By ensuring that all participants in

The science of consciousness - Basics, models, and visions.

PubMed

Hinterberger, Thilo

2015-12-01

This article presents a few models and aspects of the phenomenon consciousness that are emerging from modern neuroscience and might serve as a basis for scientific discourse in the field of Applied Consciousness Sciences. A first model describes the dynamics of information processing in the brain. The evoked electric brain potentials represent a hierarchical sequence of functions playing an important role in conscious perception. These range from primary processing, attention, pattern recognition, categorization, associations to judgments, and complex thoughts. Most functions seem to be implemented in the brain's neural network operating as a neurobiological computer. Another model treats conscious perception as a process of internalisation leading to the "self" as conscious observer. As a consequence, every conscious perception can be seen as a reduced and already interpreted observation of an inner representation of an outer or imagined "world." Subjective experience thus offers properties which can only be experienced from the inside and cannot be made objective. Basic values of humanity such as responsibility, love, compassion, freedom, and dignity can be derived from these subjective qualities. Therefore, in contrast to the Natural Sciences, the Science of Consciousness additionally is challenged to deal with those subjective qualities, emphasizing the resulting influence on health, social interactions, and the whole society. Copyright © 2015 Elsevier Ltd. All rights reserved.

Conducting correlation seminars in basic sciences at KIST Medical College, Nepal

PubMed Central

2011-01-01

KIST Medical College is a new medical school in Lalitpur, Nepal. In Nepal, six basic science subjects are taught together in an integrated organ system-based manner with early clinical exposure and community medicine. Correlation seminars are conducted at the end of covering each organ system. The topics are decided by the core academic group (consisting of members from each basic science department, the Department of Community Medicine, the academic director, and the clinical and program coordinators) considering the public health importance of the condition and its ability to include learning objectives from a maximum number of subjects. The learning objectives are decided by individual departments and finalized after the meeting of the core group. There are two student coordinators for each seminar and an evaluation group evaluates each seminar and presenter. Correlation seminars help students revise the organ system covered and understand its clinical importance, promote teamwork and organization, and supports active learning. Correlation seminars should be considered as a learning modality by other medical schools. PMID:22066033

The Neuropsychoanalytic Approach: Using Neuroscience as the Basic Science of Psychoanalysis

PubMed Central

Johnson, Brian; Flores Mosri, Daniela

2016-01-01

Neuroscience was the basic science behind Freud's psychoanalytic theory and technique. He worked as a neurologist for 20 years before being aware that a new approach to understand complex diseases, namely the hysterias, was needed. Solms coined the term neuropsychoanalysis to affirm that neuroscience still belongs in psychoanalysis. The neuropsychoanalytic field has continued Freud's original ideas as stated in 1895. Developments in psychoanalysis that have been created or revised by the neuropsychoanalysis movement include pain/relatedness/opioids, drive, structural model, dreams, cathexis, and dynamic unconscious. Neuroscience has contributed to the development of new psychoanalytic theory, such as Bazan's (2011) description of anxiety driven by unconscious intentions or “phantoms.” Results of adopting the “dual aspect monism” approach of idiographic psychoanalytic clinical observation combined with nomothetic investigation of related human phenomena include clarification and revision of theory, restoration of the scientific base of psychoanalysis, and improvement of clinical treatments. By imbricating psychoanalytic thinking with neuroscience, psychoanalysts are also positioned to make contributions to neuroscience research. Freud's original Project for a Scientific Psychology/Psychology for Neurologists can be carried forward in a way that moves psychoanalysis into the twenty-first century as a core contemporary science (Kandel, 1999). Neuroscience as the basic science of psychoanalysis both improves the field, and enhances its scientific and cultural status. PMID:27790160

The United Nations Basic Space Science Initiative (UNBSSI): A Historical Introduction

NASA Astrophysics Data System (ADS)

Haubold, H. J.

2006-11-01

Pursuant to recommendations of the Third United Nations Conference on the Exploration and Peaceful Uses of Outer Space (UNISPACE III) and deliberations of the United Nations Committee on the Peaceful Uses of Outer Space (UNCOPUOS), annual UN/European Space Agency workshops on basic space science have been held around the world since 1991. These workshops contributed to the development of astrophysics and space science, particularly in developing nations. Following a process of prioritization, the workshops identified the following elements as particularly important for international cooperation in the field: (i) operation of astronomical telescope facilities implementing TRIPOD, (ii) virtual observatories, (iii) astrophysical data systems, (iv) con-current design capabilities for the development of international space missions, and (v) theoretical astrophysics such as applications of non-extensive statistical mechanics. Beginning in 2005, the workshops are focusing on preparations for the International Heliophysical Year 2007 (IHY2007). The workshops continue to facilitate the establishment of astronomical telescope facilities as pursued by Japan and the development of low-cost, ground-based, world- wide instrument arrays as led by the IHY secretariat. Wamsteker, W., Albrecht, R. and Haubold, H.J.: Developing Basic Space Science World-Wide: A Decade of UN/ESA Workshops: Kluwer Academic Publishers, Dordrecht 2004. http://ihy2007.org http://www.unoosa.org/oosa/en/SAP/bss/ihy2007/index.html http://www.cbpf.br/GrupPesq/StatisticalPhys/biblio.htm

Aligning library instruction with the needs of basic sciences graduate students: a case study.

PubMed

O'Malley, Donna; Delwiche, Frances A

2012-10-01

How can an existing library instruction program be reconfigured to reach basic sciences graduate students and other patrons missed by curriculum-based instruction? The setting is an academic health sciences library that serves both the university and its affiliated teaching hospital. The existing program was redesigned to incorporate a series of seven workshops that encompassed the range of information literacy skills that graduate students in the basic sciences need. In developing the new model, the teaching librarians made changes in pedagogy, technology, marketing, and assessment strategies. Total attendance at the sessions increased substantially in the first 2 years of the new model, increasing from an average of 20 per semester to an average of 124. Survey results provided insight about what patrons wanted to learn and how best to teach it. Modifying the program's content and structure resulted in a program that appealed to the target audience.

Basic science curriculums in nuclear cardiology and cardiovascular imaging: evolving and emerging concepts.

PubMed

Van Decker, William A; Villafana, Theodore

2008-01-01

The teaching of basic science with regard to physics, instrumentation, and radiation safety has been part of nuclear cardiology training since its inception. Although there are clear educational and quality rationale for such, regulations associated with the Nuclear Regulatory Commission Subpart J of old 10 CFR section 35 (Title 10, Code of Federal Regulations, Part 35) from the 1960s mandated such prescriptive instruction. Cardiovascular fellowship training programs now have a new opportunity to rethink their basic science imaging curriculums with the era of "revised 10 CFR section 35" and the growing implementation of multimodality imaging training and expertise. This review focuses on the history and the why, what, and how of such a curriculum arising in one city and suggests examples of future implementation in other locations.

Separation of circadian and wake duration-dependent modulation of EEG activation during wakefulness

NASA Technical Reports Server (NTRS)

Cajochen, C.; Wyatt, J. K.; Czeisler, C. A.; Dijk, D. J.

2002-01-01

The separate contribution of circadian rhythmicity and elapsed time awake on electroencephalographic (EEG) activity during wakefulness was assessed. Seven men lived in an environmental scheduling facility for 4 weeks and completed fourteen 42.85-h 'days', each consisting of an extended (28.57-h) wake episode and a 14.28-h sleep opportunity. The circadian rhythm of plasma melatonin desynchronized from the 42.85-h day. This allowed quantification of the separate contribution of circadian phase and elapsed time awake to variation in EEG power spectra (1-32 Hz). EEG activity during standardized behavioral conditions was markedly affected by both circadian phase and elapsed time awake in an EEG frequency- and derivation-specific manner. The nadir of the circadian rhythm in alpha (8-12 Hz) activity in both fronto-central and occipito-parietal derivations occurred during the biological night, close to the crest of the melatonin rhythm. The nadir of the circadian rhythm of theta (4.5-8 Hz) and beta (20-32 Hz) activity in the fronto-central derivation was located close to the onset of melatonin secretion, i.e. during the wake maintenance zone. As time awake progressed, delta frequency (1-4.5 Hz) and beta (20-32 Hz) activity rose monotonically in frontal derivations. The interaction between the circadian and wake-dependent increase in frontal delta was such that the intrusion of delta was minimal when sustained wakefulness coincided with the biological day, but pronounced during the biological night. Our data imply that the circadian pacemaker facilitates frontal EEG activation during the wake maintenance zone, by generating an arousal signal that prevents the intrusion of low-frequency EEG components, the propensity for which increases progressively during wakefulness.

Dynamics and control of hydrofoil wakes

NASA Astrophysics Data System (ADS)

Kjeldsen, Morten; Wosnik, Martin; Arndt, Roger

2008-11-01

The problem of rotor-stator interaction (RSI) is an issue within the field of turbomachinery. The flow field entering the rotor cascade will depend on the stator blade to blade velocity distributions, and the viscous wake trailing cascade blades. This flow field is also dependent on the mode of operation, e.g by changing the angle of each blade in hydroturbines. Manipulating the stator viscous wakes is one method to minimize the problems associated RSI; i.e. noise and vibration. In order to explore this concept, a comprehensive experimental program was carried out in a high-speed water tunnel utilizing a series of NACA 0015 hydrofoils. Baseline wake data were collected with a hydraulically smooth foil and compared with two foils modified with two sizes of vortex generators (VG) positioned close to the leading edge of the foil. Not only was the effect of the modifications on wake spreading investigated but also the effect on wake dynamics such as vortex shedding was studied. A high frame-rate PIV system was used at recording rates of 1 and 10 kHz to map the near wake region, extending roughly 1 chord-length downstream the trailing edge, over a range of angles of attack and velocities. The results show that wake dynamics and wake characteristics, i.e. velocity deficit and width, scale with average drag. It was demonstrated that the use of VGs can improve both the dynamics and spreading characteristics of the wake.

Mesenchymal Stem Cells in Lipogems, a Reverse Story: from Clinical Practice to Basic Science.

PubMed

Tremolada, Carlo; Ricordi, Camillo; Caplan, Arnold I; Ventura, Carlo

2016-01-01

The idea that basic science should be the starting point for modern clinical approaches has been consolidated over the years, and emerged as the cornerstone of Molecular Medicine. Nevertheless, there is increasing concern over the low efficiency and inherent costs related to the translation of achievements from the bench to the bedside. These burdens are also perceived with respect to the effectiveness of translating basic discoveries in stem cell biology to the newly developing field of advanced cell therapy or Regenerative Medicine. As an alternative paradigm, past and recent history in Medical Science provides remarkable reverse stories in which clinical observations at the patient's bedside have fed major advances in basic research which, in turn, led to consistent progression in clinical practice. Within this context, we discuss our recently developed method and device, which forms the core of a system (Lipogems) for processing of human adipose tissue solely with the aid of mild mechanical forces to yield a microfractured tissue product.

Cosmic string wakes and large-scale structure

NASA Technical Reports Server (NTRS)

Charlton, Jane C.

1988-01-01

The formation of structure from infinite cosmic string wakes is modeled for a universe dominated by cold dark matter (CDM). Cross-sectional slices through the wake distribution tend to outline empty regions with diameters which are not inconsistent with the range of sizes of the voids in the CfA slice of the universe. The topology of the wake distribution is found to be spongy rather than cell-like. Correlations between CDM wakes do not extend much beyond a horizon length, so it is unlikely that CDM wakes are responsible for the correlations between clusters of galaxies. An estimate of the fraction of matter to accrete onto CDM wakes indicates that wakes could be more important in galaxy formation than previously anticipated.

Unsteady wake of a rotating tire

NASA Astrophysics Data System (ADS)

Lombard, Jean-Eloi; Moxey, Dave; Xu, Hui; Sherwin, Spencer; Sherwin Lab Team

2015-11-01

For open wheel race-cars, such as IndyCar and Formula One, the wheels are responsible for 40% of the total drag. For road cars drag associated to the wheels and under-carriage can represent 60% of total drag at highway cruise speeds. Experimental observations have reported two or three pairs of counter rotating vortices, the relative importance of which still remains an open question, that interact to form a complex wake. Traditional RANS based methods are typically not well equipped to deal with such highly unsteady flows which motivates research into more physical, unsteady models. Leveraging a high-fidelity spectral/hp element based method a Large Eddy Simulation is performed to give further insight into unsteady characteristics of the wake. In particular the unsteady nature of both the jetting and top vortex pair is reported as well as the time and length scales associated with the vortex core trajectories. Correlation with experimentally obtained particle image velocimetry is presented. The authors acknowledge support from the United Kingdom Turbulence Consortium (UKTC) as well as from the Engineering and Physical Sciences Research Council (EPSRC) for access to ARCHER UK National Supercomputing Service.

Key steps for integrating a basic science throughout a medical school curriculum using an e-learning approach.

PubMed

Dubois, Eline Agnès; Franson, Kari Lanette

2009-09-01

Basic sciences can be integrated into the medical school curriculum via e-learning. The process of integrating a basic science in this manner resembles a curricular change. The change usually begins with an idea for using e-learning to teach a basic science and establishing the need for the innovation. In the planning phase, learning outcomes are formulated and a prototype of the program is developed based on the desired requirements. A realistic concept is formed after considering the limitations of the current institute. Next, a project team is assembled to develop the program and plan its integration. Incorporation of the e-learning program is facilitated by a well-developed and communicated integration plan. Various course coordinators are contacted to determine content of the e-learning program as well as establish assessment. Linking the e-learning program to existing course activities and thereby applying the basic science into the clinical context enhances the degree of integration. The success of the integration is demonstrated by a positive assessment of the program including favourable cost-benefit analysis and improved student performance. Lastly, when the program becomes institutionalised, continuously updating content and technology (when appropriate), and evaluating the integration contribute to the prolonged survival of the e-learning program.

Flow Characteristics of Ground Vehicle Wake and Its Response to Flow Control

NASA Astrophysics Data System (ADS)

Sellappan, Prabu; McNally, Jonathan; Alvi, Farrukh

2017-11-01

Air pollution, fuel shortages, and cost savings are some of the many incentives for improving the aerodynamics of vehicles. Reducing wake-induced aerodynamic drag, which is dependent on flow topology, on modern passenger vehicles is important for improving fuel consumption rates which directly affect the environment. In this research, an active flow control technique is applied on a generic ground vehicle, a 25°Ahmed model, to investigate its effect on the flow topology in the near-wake. The flow field of this canonical bluff body is extremely rich, with complex and unsteady flow features such as trailing wake vortices and c-pillar vortices. The spatio-temporal response of these flow features to the application of steady microjet actuators is investigated. The responses are characterized independently through time-resolved and volumetric velocity field measurements. The accuracy and cost of volumetric measurements in this complex flow field through Stereoscopic- and Tomographic- Particle Image Velocimetry (PIV) will also be commented upon. National Science Foundation PIRE Program.

Free wake analysis of hover performance using a new influence coefficient method

NASA Technical Reports Server (NTRS)

Quackenbush, Todd R.; Bliss, Donald B.; Ong, Ching Cho; Ching, Cho Ong

1990-01-01

A new approach to the prediction of helicopter rotor performance using a free wake analysis was developed. This new method uses a relaxation process that does not suffer from the convergence problems associated with previous time marching simulations. This wake relaxation procedure was coupled to a vortex-lattice, lifting surface loads analysis to produce a novel, self contained performance prediction code: EHPIC (Evaluation of Helicopter Performance using Influence Coefficients). The major technical features of the EHPIC code are described and a substantial amount of background information on the capabilities and proper operation of the code is supplied. Sample problems were undertaken to demonstrate the robustness and flexibility of the basic approach. Also, a performance correlation study was carried out to establish the breadth of applicability of the code, with very favorable results.

A hybrid model of mathematics support for science students emphasizing basic skills and discipline relevance

NASA Astrophysics Data System (ADS)

Jackson, Deborah C.; Johnson, Elizabeth D.

2013-09-01

The problem of students entering university lacking basic mathematical skills is a critical issue in the Australian higher-education sector and relevant globally. The Maths Skills programme at La Trobe University has been developed to address under preparation in the first-year science cohort in the absence of an institutional mathematics support centre. The programme was delivered through first-year science and statistics subjects with large enrolments and focused on basic mathematical skills relevant to each science discipline. The programme offered a new approach to the traditional mathematical support centre or class. It was designed through close collaboration between science subject coordinators and the project leader, a mathematician, and includes resources relevant to science and mathematics questions written in context. Evaluation of the programme showed it improved the confidence of the participating students who found it helpful and relevant. The programme was delivered through three learning modes to allow students to select activities most suitable for them, which was appreciated by students. Mathematics skills appeared to increase following completion of the programme and student participation in the programme correlated positively and highly with academic grades in their relevant science subjects. This programme offers an alternative model for mathematics support tailored to science disciplines.

Wake Vortex Advisory System (WakeVAS) Evaluation of Impacts on the National Airspace System

NASA Technical Reports Server (NTRS)

Smith, Jeremy C.; Dollyhigh, Samuel M.

2005-01-01

This report is one of a series that describes an ongoing effort in high-fidelity modeling/simulation, evaluation and analysis of the benefits and performance metrics of the Wake Vortex Advisory System (WakeVAS) Concept of Operations being developed as part of the Virtual Airspace Modeling and Simulation (VAMS) project. A previous study, determined the overall increases in runway arrival rates that could be achieved at 12 selected airports due to WakeVAS reduced aircraft spacing under Instrument Meteorological Conditions. This study builds on the previous work to evaluate the NAS wide impacts of equipping various numbers of airports with WakeVAS. A queuing network model of the National Airspace System, built by the Logistics Management Institute, Mclean, VA, for NASA (LMINET) was used to estimate the reduction in delay that could be achieved by using WakeVAS under non-visual meteorological conditions for the projected air traffic demand in 2010. The results from LMINET were used to estimate the total annual delay reduction that could be achieved and from this, an estimate of the air carrier variable operating cost saving was made.

What does the American Board of Surgery In-Training/Surgical Basic Science Examination tell us about graduate surgical education?

PubMed

DaRosa, D A; Shuck, J M; Biester, T W; Folse, R

1993-01-01

This research sought to identify the strengths and weakness in residents' basic science knowledge and, second, to determine whether they progressively improve in their abilities to recall basic science information and clinical management facts, to analyze cause-effect relationships, and to solve clinical problems. Basic science knowledge was assessed by means of the results of the January 1990 American Board of Surgery's In-Training/Surgical Basic Science Exam (IT/SBSE). Postgraduate year (PGY) 1 residents' scores were compared with those of PGY5 residents. Content related to a question was considered "known" if 67% or more of the residents in each of the two groups answered it correctly. Findings showed 44% of the content tested by the basic science questions were unknown by new and graduating residents. The second research question required the 250 IT/SBSE questions to be classified into one of three levels of thinking abilities: recall, analysis, and inferential thinking. Profile analysis (split-plot analysis of variance) for each pair of resident levels indicated significant (P < 0.001) differences in performance on questions requiring factual recall, analysis, and inference between all levels except for PGY3s and PGY4s. The results of this research enable program directors to evaluate strengths and weaknesses in residency training curricula and the cognitive development of residents.

Wake-Vortex Hazards During Cruise

NASA Technical Reports Server (NTRS)

Rossow, Vernon J.; James, Kevin D.; Nixon, David (Technical Monitor)

1998-01-01

Even though the hazard posed by lift-generated wakes of subsonic transport aircraft has been studied extensively for approach and departure at airports, only a small amount of effort has gone into the potential hazard at cruise altitude. This paper reports on a studio of the wake-vortex hazard during cruise because encounters may become more prevalent when free-flight becomes available and each aircraft, is free to choose its own route between destinations. In order to address the problem, the various fluid-dynamic stages that vortex wakes usually go through as they age will be described along with estimates of the potential hazard that each stage poses. It appears that a rolling-moment hazard can be just as severe at cruise as for approach at airports, but it only persists for several minutes. However, the hazard posed by the downwash in the wake due to the lift on the generator aircraft persists for tens of minutes in a long narrow region behind the generating aircraft. The hazard consists of severe vertical loads when an encountering aircraft crosses the wake. A technique for avoiding vortex wakes at cruise altitude will be described. To date the hazard posed by lift-generated vortex wakes and their persistence at cruise altitudes has been identified and subdivided into several tasks. Analyses of the loads to be encounter and are underway and should be completed shortly. A review of published literature on the subject has been nearly completed (see text) and photographs of vortex wakes at cruise altitudes have been taken and the various stages of decay have been identified. It remains to study and sort the photographs for those that best illustrate the various stages of decay after they are shed by subsonic transport aircraft at cruise altitudes. The present status of the analysis and the paper are described.

Three-Phased Wake Vortex Decay

NASA Technical Reports Server (NTRS)

Proctor, Fred H.; Ahmad, Nashat N.; Switzer, George S.; LimonDuparcmeur, Fanny M.

2010-01-01

A detailed parametric study is conducted that examines vortex decay within turbulent and stratified atmospheres. The study uses a large eddy simulation model to simulate the out-of-ground effect behavior of wake vortices due to their interaction with atmospheric turbulence and thermal stratification. This paper presents results from a parametric investigation and suggests improvements for existing fast-time wake prediction models. This paper also describes a three-phased decay for wake vortices. The third phase is characterized by a relatively slow rate of circulation decay, and is associated with the ringvortex stage that occurs following vortex linking. The three-phased decay is most prevalent for wakes imbedded within environments having low-turbulence and near-neutral stratification.

Aligning library instruction with the needs of basic sciences graduate students: a case study

PubMed Central

O'Malley, Donna; Delwiche, Frances A.

2012-01-01

Question: How can an existing library instruction program be reconfigured to reach basic sciences graduate students and other patrons missed by curriculum-based instruction? Setting: The setting is an academic health sciences library that serves both the university and its affiliated teaching hospital. Methods: The existing program was redesigned to incorporate a series of seven workshops that encompassed the range of information literacy skills that graduate students in the basic sciences need. In developing the new model, the teaching librarians made changes in pedagogy, technology, marketing, and assessment strategies. Results: Total attendance at the sessions increased substantially in the first 2 years of the new model, increasing from an average of 20 per semester to an average of 124. Survey results provided insight about what patrons wanted to learn and how best to teach it. Conclusion: Modifying the program's content and structure resulted in a program that appealed to the target audience. PMID:23133328

Wake shed by an accelerating carangiform fish

NASA Astrophysics Data System (ADS)

Ting, Shang-Chieh; Yang, Jing-Tang

2008-11-01

We reveal an important fact that momentum change observed in the wake of an accelerating carangiform fish does not necessarily elucidate orientations of propulsive forces produced. An accelerating Crucian Carp (Carassius auratus) was found to shed a wake with net forward fluid momentum, which seemed drag-producing. Based on Newton's law, however, an accelerating fish is expected to shed a thrust wake with net rearward fluid momentum, rather than a drag wake. The unusual wake pattern observed is considered to be resulted primarily from the effect of pressure gradient created by accelerating movements of the fish. Ambient fluids tend to be sucked into low pressure zones behind an accelerating fish, resulting in forward orientations of jets recognizable in the wake. Accordingly, as to an accelerating fish, identifying force orientations from the wake requires considering also the effect of pressure gradient.

Multi-Model Ensemble Wake Vortex Prediction

NASA Technical Reports Server (NTRS)

Koerner, Stephan; Holzaepfel, Frank; Ahmad, Nash'at N.

2015-01-01

Several multi-model ensemble methods are investigated for predicting wake vortex transport and decay. This study is a joint effort between National Aeronautics and Space Administration and Deutsches Zentrum fuer Luft- und Raumfahrt to develop a multi-model ensemble capability using their wake models. An overview of different multi-model ensemble methods and their feasibility for wake applications is presented. The methods include Reliability Ensemble Averaging, Bayesian Model Averaging, and Monte Carlo Simulations. The methodologies are evaluated using data from wake vortex field experiments.

Contributions of the stochastic shape wake model to predictions of aerodynamic loads and power under single wake conditions

DOE Office of Scientific and Technical Information (OSTI.GOV)

Doubrawa, P.; Barthelmie, R. J.; Wang, H.

The contribution of wake meandering and shape asymmetry to load and power estimates is quantified by comparing aeroelastic simulations initialized with different inflow conditions: an axisymmetric base wake, an unsteady stochastic shape wake, and a large-eddy simulation with rotating actuator-line turbine representation. Time series of blade-root and tower base bending moments are analyzed. We find that meandering has a large contribution to the fluctuation of the loads. Moreover, considering the wake edge intermittence via the stochastic shape model improves the simulation of load and power fluctuations and of the fatigue damage equivalent loads. Furthermore, these results indicate that the stochasticmore » shape wake simulator is a valuable addition to simplified wake models when seeking to obtain higher-fidelity computationally inexpensive predictions of loads and power.« less

Contributions of the stochastic shape wake model to predictions of aerodynamic loads and power under single wake conditions

DOE PAGES

Doubrawa, P.; Barthelmie, R. J.; Wang, H.; ...

2016-10-03

The contribution of wake meandering and shape asymmetry to load and power estimates is quantified by comparing aeroelastic simulations initialized with different inflow conditions: an axisymmetric base wake, an unsteady stochastic shape wake, and a large-eddy simulation with rotating actuator-line turbine representation. Time series of blade-root and tower base bending moments are analyzed. We find that meandering has a large contribution to the fluctuation of the loads. Moreover, considering the wake edge intermittence via the stochastic shape model improves the simulation of load and power fluctuations and of the fatigue damage equivalent loads. Furthermore, these results indicate that the stochasticmore » shape wake simulator is a valuable addition to simplified wake models when seeking to obtain higher-fidelity computationally inexpensive predictions of loads and power.« less

Identification of Causal Genes, Networks, and Transcriptional Regulators of REM Sleep and Wake

PubMed Central

Millstein, Joshua; Winrow, Christopher J.; Kasarskis, Andrew; Owens, Joseph R.; Zhou, Lili; Summa, Keith C.; Fitzpatrick, Karrie; Zhang, Bin; Vitaterna, Martha H.; Schadt, Eric E.; Renger, John J.; Turek, Fred W.

2011-01-01

Study Objective: Sleep-wake traits are well-known to be under substantial genetic control, but the specific genes and gene networks underlying primary sleep-wake traits have largely eluded identification using conventional approaches, especially in mammals. Thus, the aim of this study was to use systems genetics and statistical approaches to uncover the genetic networks underlying 2 primary sleep traits in the mouse: 24-h duration of REM sleep and wake. Design: Genome-wide RNA expression data from 3 tissues (anterior cortex, hypothalamus, thalamus/midbrain) were used in conjunction with high-density genotyping to identify candidate causal genes and networks mediating the effects of 2 QTL regulating the 24-h duration of REM sleep and one regulating the 24-h duration of wake. Setting: Basic sleep research laboratory. Patients or Participants: Male [C57BL/6J × (BALB/cByJ × C57BL/6J*) F1] N2 mice (n = 283). Interventions: None. Measurements and Results: The genetic variation of a mouse N2 mapping cross was leveraged against sleep-state phenotypic variation as well as quantitative gene expression measurement in key brain regions using integrative genomics approaches to uncover multiple causal sleep-state regulatory genes, including several surprising novel candidates, which interact as components of networks that modulate REM sleep and wake. In particular, it was discovered that a core network module, consisting of 20 genes, involved in the regulation of REM sleep duration is conserved across the cortex, hypothalamus, and thalamus. A novel application of a formal causal inference test was also used to identify those genes directly regulating sleep via control of expression. Conclusion: Systems genetics approaches reveal novel candidate genes, complex networks and specific transcriptional regulators of REM sleep and wake duration in mammals. Citation: Millstein J; Winrow CJ; Kasarskis A; Owens JR; Zhou L; Summa KC; Fitzpatrick K; Zhang B; Vitaterna MH; Schadt EE

Wake measurements in a strong adverse pressure gradient

NASA Technical Reports Server (NTRS)

Hoffenberg, R.; Sullivan, John P.; Schneider, S. P.

1994-01-01

The behavior of wakes in adverse pressure gradients is critical to the performance of high-lift systems for transport aircraft. Wake deceleration is known to lead to sudden thickening and the onset of reversed flow; this 'wake bursting' phenomenon can occur while surface flows remain attached. Although 'wake bursting' is known to be important for high-lift systems, no detailed measurements of 'burst' wakes have ever been reported. Wake bursting has been successfully achieved in the wake of a flat plate as it decelerated in a two-dimensional diffuser, whose sidewalls were forced to remain attached by use of slot blowing. Pilot probe surveys, L.D.V. measurements, and flow visualization have been used to investigate the physics of this decelerated wake, through the onset of reversed flow.

Evolution in health and medicine Sackler colloquium: Making evolutionary biology a basic science for medicine.

PubMed

Nesse, Randolph M; Bergstrom, Carl T; Ellison, Peter T; Flier, Jeffrey S; Gluckman, Peter; Govindaraju, Diddahally R; Niethammer, Dietrich; Omenn, Gilbert S; Perlman, Robert L; Schwartz, Mark D; Thomas, Mark G; Stearns, Stephen C; Valle, David

2010-01-26

New applications of evolutionary biology in medicine are being discovered at an accelerating rate, but few physicians have sufficient educational background to use them fully. This article summarizes suggestions from several groups that have considered how evolutionary biology can be useful in medicine, what physicians should learn about it, and when and how they should learn it. Our general conclusion is that evolutionary biology is a crucial basic science for medicine. In addition to looking at established evolutionary methods and topics, such as population genetics and pathogen evolution, we highlight questions about why natural selection leaves bodies vulnerable to disease. Knowledge about evolution provides physicians with an integrative framework that links otherwise disparate bits of knowledge. It replaces the prevalent view of bodies as machines with a biological view of bodies shaped by evolutionary processes. Like other basic sciences, evolutionary biology needs to be taught both before and during medical school. Most introductory biology courses are insufficient to establish competency in evolutionary biology. Premedical students need evolution courses, possibly ones that emphasize medically relevant aspects. In medical school, evolutionary biology should be taught as one of the basic medical sciences. This will require a course that reviews basic principles and specific medical applications, followed by an integrated presentation of evolutionary aspects that apply to each disease and organ system. Evolutionary biology is not just another topic vying for inclusion in the curriculum; it is an essential foundation for a biological understanding of health and disease.

Evolution of Rotor Wake in Swirling Flow

NASA Technical Reports Server (NTRS)

El-Haldidi, Basman; Atassi, Hafiz; Envia, Edmane; Podboy, Gary

2000-01-01

A theory is presented for modeling the evolution of rotor wakes as a function of axial distance in swirling mean flows. The theory, which extends an earlier work to include arbitrary radial distributions of mean swirl, indicates that swirl can significantly alter the wake structure of the rotor especially at large downstream distances (i.e., for moderate to large rotor-stator spacings). Using measured wakes of a representative scale model fan stage to define the mean swirl and initial wake perturbations, the theory is used to predict the subsequent evolution of the wakes. The results indicate the sensitivity of the wake evolution to the initial profile and the need to have complete and consistent initial definition of both velocity and pressure perturbations.

Effects of Concept Mapping Instruction Approach on Students' Achievement in Basic Science

ERIC Educational Resources Information Center

Ogonnaya, Ukpai Patricia; Okafor, Gabriel; Abonyi, Okechukwu S.; Ugama, J. O.

2016-01-01

The study investigated the effects of concept mapping on students' achievement in basic science. The study was carried out in Ebonyi State of Nigeria. The study employed a quasi-experimental design. Specifically the pretest posttest non-equivalent control group research design was used. The sample was 122 students selected from two secondary…

Spatial Linear Instability of Confluent Wake/Boundary Layers

NASA Technical Reports Server (NTRS)

Liou, William W.; Liu, Feng-Jun; Rumsey, C. L. (Technical Monitor)

2001-01-01

The spatial linear instability of incompressible confluent wake/boundary layers is analyzed. The flow model adopted is a superposition of the Blasius boundary layer and a wake located above the boundary layer. The Orr-Sommerfeld equation is solved using a global numerical method for the resulting eigenvalue problem. The numerical procedure is validated by comparing the present solutions for the instability of the Blasius boundary layer and for the instability of a wake with published results. For the confluent wake/boundary layers, modes associated with the boundary layer and the wake, respectively, are identified. The boundary layer mode is found amplified as the wake approaches the wall. On the other hand, the modes associated with the wake, including a symmetric mode and an antisymmetric mode, are stabilized by the reduced distance between the wall and the wake. An unstable mode switching at low frequency is observed where the antisymmetric mode becomes more unstable than the symmetric mode when the wake velocity defect is high.

Absolute instability of the Gaussian wake profile

NASA Technical Reports Server (NTRS)

Hultgren, Lennart S.; Aggarwal, Arun K.

1987-01-01

Linear parallel-flow stability theory has been used to investigate the effect of viscosity on the local absolute instability of a family of wake profiles with a Gaussian velocity distribution. The type of local instability, i.e., convective or absolute, is determined by the location of a branch-point singularity with zero group velocity of the complex dispersion relation for the instability waves. The effects of viscosity were found to be weak for values of the wake Reynolds number, based on the center-line velocity defect and the wake half-width, larger than about 400. Absolute instability occurs only for sufficiently large values of the center-line wake defect. The critical value of this parameter increases with decreasing wake Reynolds number, thereby indicating a shrinking region of absolute instability with decreasing wake Reynolds number. If backflow is not allowed, absolute instability does not occur for wake Reynolds numbers smaller than about 38.

Pharmaceutical applications of cyclodextrins: basic science and product development.

PubMed

Loftsson, Thorsteinn; Brewster, Marcus E

2010-11-01

Drug pipelines are becoming increasingly difficult to formulate. This is punctuated by both retrospective and prospective analyses that show that while 40% of currently marketed drugs are poorly soluble based on the definition of the biopharmaceutical classification system (BCS), about 90% of drugs in development can be characterized as poorly soluble. Although a number of techniques have been suggested for increasing oral bioavailability and for enabling parenteral formulations, cyclodextrins have emerged as a productive approach. This short review is intended to provide both some basic science information as well as data on the ability to develop drugs in cyclodextrin-containing formulations. There are currently a number of marketed products that make use of these functional solubilizing excipients and new product introduction continues to demonstrate their high added value. The ability to predict whether cyclodextrins will be of benefit in creating a dosage form for a particular drug candidate requires a good working knowledge of the properties of cyclodextrins, their mechanism of solubilization and factors that contribute to, or detract from, the biopharmaceutical characteristics of the formed complexes. We provide basic science information as well as data on the development of drugs in cyclodextrin-containing formulations. Cyclodextrins have emerged as an important tool in the formulator's armamentarium to improve apparent solubility and dissolution rate for poorly water-soluble drug candidates. The continued interest and productivity of these materials bode well for future application and their currency as excipients in research, development and drug product marketing. © 2010 The Authors. Journal compilation © 2010 Royal Pharmaceutical Society of Great Britain.

Coupled wake boundary layer model of windfarms

NASA Astrophysics Data System (ADS)

Stevens, Richard; Gayme, Dennice; Meneveau, Charles

2014-11-01

We present a coupled wake boundary layer (CWBL) model that describes the distribution of the power output in a windfarm. The model couples the traditional, industry-standard wake expansion/superposition approach with a top-down model for the overall windfarm boundary layer structure. Wake models capture the effect of turbine positioning, while the top-down approach represents the interaction between the windturbine wakes and the atmospheric boundary layer. Each portion of the CWBL model requires specification of a parameter that is unknown a-priori. The wake model requires the wake expansion rate, whereas the top-down model requires the effective spanwise turbine spacing within which the model's momentum balance is relevant. The wake expansion rate is obtained by matching the mean velocity at the turbine from both approaches, while the effective spanwise turbine spacing is determined from the wake model. Coupling of the constitutive components of the CWBL model is achieved by iterating these parameters until convergence is reached. We show that the CWBL model predictions compare more favorably with large eddy simulation results than those made with either the wake or top-down model in isolation and that the model can be applied successfully to the Horns Rev and Nysted windfarms. The `Fellowships for Young Energy Scientists' (YES!) of the Foundation for Fundamental Research on Matter supported by NWO, and NSF Grant #1243482.

Retinogeniculate transmission in wakefulness.

PubMed

Weyand, Theodore G

2007-08-01

Despite popular belief that the primary function of the thalamus is to "gate" sensory inputs by state, few studies have attempted to directly characterize the efficacy of such gating in the awake, behaving animal. I measured the efficacy of retinogeniculate transmission in the awake cat by taking advantage of the fact that many neurons in the lateral geniculate nucleus (LGN) are dominated by a single retinal input, and that this input produces a distinct event known as the S-potential. Retinal input failed to produce an LGN action potential half of the time. However, success or failure was powerfully tied to the recency of the S-potential. Short intervals tend to be successful and long intervals unsuccessful. For four of 12 neurons, the probability that a given S-potential could cause a spike exceeded 90% if that S-potential was preceded by an S-potential within the previous 10 ms (100 Hz). Whereas this temporal influence on efficacy has been demonstrated extensively in anesthetized animals, wakefulness is different in several ways. Overall efficacy is better in wakefulness than in anesthesia, the durations of facilitating effects are briefer in wakefulness, efficacy of long intervals is superior in wakefulness, and the temporal dependence can be briefly disrupted by altering background illumination. The last two observations may be particularly significant. Increased success at long intervals in wakefulness provides additional evidence that the spike code of the anesthetized animal is not the spike code of the awake animal. Altering retinogeniculate efficacy by altering visual conditions undermines the influence inter-S-potential interval might have in determining efficacy in the real world. Finally, S-potential amplitude, duration, and even slope are dynamic and systematic within wakefulness; providing further support that the S-potential is the extracellular signature of the retinal EPSP.

The Accidental Toxicologist: A Career in the Science of ...

EPA Pesticide Factsheets

This PowerPoint presentation is part of a Health Science Career fair for Wake County, NC high school students. The purpose is to familiarize students with careers in the health sciences and the education necessary to be eligible for those careers. This presentation is part of a Health Science Career fair for Wake County, NC high school students. The purpose is to familiarize students with careers in the health sciences and the education necessary to be eligible for those careers.

Analysis of a high brightness photo electron beam with self field and wake field effects

DOE Office of Scientific and Technical Information (OSTI.GOV)

Parsa, Z.

High brightness sources are the basic ingredients in the new accelerator developments such as Free-Electron Laser experiments. The effects of the interactions between the highly charged particles and the fields in the accelerating structure, e.g. R.F., Space charge and Wake fields can be detrimental to the beam and the experiments. We present and discuss the formulation used, some simulation and results for the Brookhaven National Laboratory high brightness beam that illustrates effects of the accelerating field, space charge forces (e.g. due to self field of the bunch), and the wake field (e.g. arising from the interaction of the cavity surfacemore » and the self field of the bunch).« less

Cancer Pharmacogenomics: Integrating Discoveries in Basic, Clinical and Population Sciences to Advance Predictive Cancer Care

Cancer.gov

Cancer Pharmacogenomics: Integrating Discoveries in Basic, Clinical and Population Sciences to Advance Predictive Cancer Care, a 2010 workshop sponsored by the Epidemiology and Genomics Research Program.

The Divergent Thinking of Basic Skills of Sciences Process Skills of Life Aspects on Natural Sciences Subject in Indonesian Elementary School Students

ERIC Educational Resources Information Center

Subali, Bambang; Paidi; Mariyam, Siti

2016-01-01

This research aims at measuring the divergent thinking of basic skills of science process skills (SPS) of life aspects in Natural Sciences subjects on Elementary School. The test instruments used in this research have been standardized through the development of instruments. In this case, the tests were tried out to 3070 students. The results of…

Integration of Basic and Clinical Science Courses in US PharmD Programs.

PubMed

Islam, Mohammed A; Talukder, Rahmat M; Taheri, Reza; Blanchard, Nicholas

2016-12-25

Objective. To determine the current status of and faculty perceptions regarding integration of basic and clinical science courses in US pharmacy programs. Methods. A 25-item survey instrument was developed and distributed to 132 doctor of pharmacy (PharmD) programs. Survey data were analyzed using Mann-Whitney U test or Kruskal-Wallis test. Thematic analysis of text-based comments was performed using the constant comparison method. Results. One hundred twelve programs responded for a response rate of 85%. Seventy-eight (70%) offered integrated basic and clinical science courses. The types of integration included: full integration with merging disciplinary contents (n=25), coordinated delivery of disciplinary contents (n=50), and standalone courses with integrated laboratory (n=3). Faculty perceptions of course integration were positive. Themes that emerged from text-based comments included positive learning experiences as well as the challenges, opportunities, and skepticism associated with course integration. Conclusion. The results suggest wide variations in the design and implementation of integrated courses among US pharmacy programs. Faculty training and buy-in play a significant role in successful implementation of curricular integration.

Integration of Basic and Clinical Science Courses in US PharmD Programs

PubMed Central

Talukder, Rahmat M.; Taheri, Reza; Blanchard, Nicholas

2016-01-01

Objective. To determine the current status of and faculty perceptions regarding integration of basic and clinical science courses in US pharmacy programs. Methods. A 25-item survey instrument was developed and distributed to 132 doctor of pharmacy (PharmD) programs. Survey data were analyzed using Mann-Whitney U test or Kruskal-Wallis test. Thematic analysis of text-based comments was performed using the constant comparison method. Results. One hundred twelve programs responded for a response rate of 85%. Seventy-eight (70%) offered integrated basic and clinical science courses. The types of integration included: full integration with merging disciplinary contents (n=25), coordinated delivery of disciplinary contents (n=50), and standalone courses with integrated laboratory (n=3). Faculty perceptions of course integration were positive. Themes that emerged from text-based comments included positive learning experiences as well as the challenges, opportunities, and skepticism associated with course integration. Conclusion. The results suggest wide variations in the design and implementation of integrated courses among US pharmacy programs. Faculty training and buy-in play a significant role in successful implementation of curricular integration. PMID:28179715

Calculation of wake vortex structures in the near-field wake behind cruising aircraft

NASA Astrophysics Data System (ADS)

Ehret, T.; Oertel, H.

Wake flows behind cruising aircraft influence the distribution of the exhaust gases. A three-dimensional vortex filament method was developed to calculate the vortex structures and the velocity field of the vorticity dominated wake flows as an integration of the Biot-Savart law. For three-dimensional vortex filament calculations, self-induction singularities were prevented using a finite vortex core for each vortex filament. Numerical simulations show the vortex structures and the velocity field in the wake behind a cruising Boeing 747 as a result of the integration of the Biot-Savart law. It is further shown how the structures of the fully rolled-up trailing vortices depend on the wing span loading, i.e. the circulation distribution.

Vortex wake control via smart structures technology

NASA Astrophysics Data System (ADS)

Quackenbush, Todd R.; Bilanin, Alan J.; McKillip, Robert M., Jr.

1996-05-01

Control of trailing vortex wakes is an important challenges for both military and civilian applications. This paper summarizes an assessment of the feasibility of mitigating adverse vortex wake effects using control surfaces actuated via Shape Memory Alloy (SMA) technology. The assessment involved a combined computational/design analysis that identified methods for introducing small secondary vortices to promote the deintensification of vortex wakes of submarines and aircraft. Computational analyses of wake breakup using this `vortex leveraging' strategy were undertaken, and showed dramatic increases in the dissipation rate of concentrated vortex wakes. This paper briefly summarizes these results and describes the preliminary design of actuation mechanisms for the deflectable surfaces that effect the required time-varying wake perturbations. These surfaces, which build on the high-force, high- deflection capabilities of SMA materials, are shown to be well suited for the very low frequency actuation requirements of the wake deintensification mission. The paper outlines the assessment of device performance capabilities and describes the sizing studies undertaken for full-scale Vortex Leveraging Tabs (VLTs) designed for use in hydrodynamic and aerodynamic applications. Results obtained to date indicate that the proposed VLTs can accelerate wake breakup by over a factor of three and can be implemented using deflectable surfaces actuated using SMAs.

Nonlinear Kinetic Instabilities in Plasma Wakes

NASA Astrophysics Data System (ADS)

Hutchinson, I. H.; Haakonsen, C. B.

2015-12-01

Relative motion of a plasma and an embedded perturbing solid objectproduces a plasma wake, which is kinetically unstable. For moons,asteroids, spacecraft, probes, and planets without a magnetosphere theresponse is dominantly electrostatic, although generally with abackground magnetic field. Using high-fidelity particle-in-cellsimulations, we have observed the development of kinetic instabilitiesand their non-linear consequences in representative wakes. We havealso explained the observations with semi-analytical non-lineartheory. The ion and electron distribution function shapes are stronglyperturbed in the wake region. The ions form two opposite beamsdirected inward along the guiding magnetic field, in part because ofthe attraction of the wake's electric potential well. The electrondistribution forms a notch or dimple (of reduced phase space density)localized in velocity to orbits that dwell near the wake axis (becauseof repulsion). Those orbits are de-energized by cross-field drift downthe potential-energy ridge. The resulting Langmuir instability spawnselectron holes. The holes that move faster than the ion beams areaccelerated out of the wake by its electrostatic field without growingsubstantially. Some holes, however, remain in the wake at essentiallyzero parallel velocity. They grow, as a result of the same mechanismthat formed the notch: cross-field drift from a lower to a higherdensity. When the density rises by a factor of order two or three,they grow large enough to perturb the ions, tap their free energy, anddisrupt the ion streams well before they would become ion-ionunstable. Crucially, these processes depend strongly on theion/electron mass ratio and require close to physical ratio (1836) insimulations, to reveal their characteristics. Electron holes arisingfrom these processes may be widely present and observable in spaceplasma wakes.

Probes, Moons, and Kinetic Plasma Wakes

NASA Astrophysics Data System (ADS)

Hutchinson, I. H.; Malaspina, D.; Zhou, C.

2017-10-01

Nonmagnetic objects as varied as probes in tokamaks or moons in space give rise to flowing plasma wakes in which strong distortions of the ion and electron velocity distributions cause electrostatic instabilities. Non-linear phenomena such as electron holes are then produced. Historic probe theory largely ignores the resulting unstable character of the wake, but since we can now simulate computationally the non-linear wake phenomena, a timely challenge is to reassess the influence of these instabilities both on probe measurements and on the wakes themselves. Because the electron instability wavelengths are very short (typically a few Debye-lengths), controlled laboratory experiments face serious challenges in diagnosing them. That is one reason why they have long been neglected as an influence in probe interpretation. Space-craft plasma observations, by contrast, easily obtain sub-Debye-length resolution, but have difficulty with larger-scale reconstruction of the plasma spatial variation. In addition to surveying our developing understanding of wakes in magnetized plasmas, ongoing analysis of Artemis data concerning electron holes observed in the solar-wind lunar wake will be featured. Work partially supported by NASA Grant NNX16AG82G.

An Investigation of Candidate Sensor-Observable Wake Vortex Strength Parameters for the NASA Aircraft Vortex Spacing System (AVOSS)

NASA Technical Reports Server (NTRS)

Tatnall, Chistopher R.

1998-01-01

The counter-rotating pair of wake vortices shed by flying aircraft can pose a threat to ensuing aircraft, particularly on landing approach. To allow adequate time for the vortices to disperse/decay, landing aircraft are required to maintain certain fixed separation distances. The Aircraft Vortex Spacing System (AVOSS), under development at NASA, is designed to prescribe safe aircraft landing approach separation distances appropriate to the ambient weather conditions. A key component of the AVOSS is a ground sensor, to ensure, safety by making wake observations to verify predicted behavior. This task requires knowledge of a flowfield strength metric which gauges the severity of disturbance an encountering aircraft could potentially experience. Several proposed strength metric concepts are defined and evaluated for various combinations of metric parameters and sensor line-of-sight elevation angles. Representative populations of generating and following aircraft types are selected, and their associated wake flowfields are modeled using various wake geometry definitions. Strength metric candidates are then rated and compared based on the correspondence of their computed values to associated aircraft response values, using basic statistical analyses.

Evaluation of a Wake Vortex Upset Model Based on Simultaneous Measurements of Wake Velocities and Probe-Aircraft Accelerations

NASA Technical Reports Server (NTRS)

Short, B. J.; Jacobsen, R. A.

1979-01-01

Simultaneous measurements were made of the upset responses experienced and the wake velocities encountered by an instrumented Learjet probe aircraft behind a Boeing 747 vortex-generating aircraft. The vortex-induced angular accelerations experienced could be predicted within 30% by a mathematical upset response model when the characteristics of the wake were well represented by the vortex model. The vortex model used in the present study adequately represented the wake flow field when the vortices dissipated symmetrically and only one vortex pair existed in the wake.

Clinical Practice Guideline for the Treatment of Intrinsic Circadian Rhythm Sleep-Wake Disorders: Advanced Sleep-Wake Phase Disorder (ASWPD), Delayed Sleep-Wake Phase Disorder (DSWPD), Non-24-Hour Sleep-Wake Rhythm Disorder (N24SWD), and Irregular Sleep-Wake Rhythm Disorder (ISWRD). An Update for 2015

PubMed Central

Auger, R. Robert; Burgess, Helen J.; Emens, Jonathan S.; Deriy, Ludmila V.; Thomas, Sherene M.; Sharkey, Katherine M.

2015-01-01

A systematic literature review and meta-analyses (where appropriate) were performed and the GRADE approach was used to update the previous American Academy of Sleep Medicine Practice Parameters on the treatment of intrinsic circadian rhythm sleep-wake disorders. Available data allowed for positive endorsement (at a second-tier degree of confidence) of strategically timed melatonin (for the treatment of DSWPD, blind adults with N24SWD, and children/ adolescents with ISWRD and comorbid neurological disorders), and light therapy with or without accompanying behavioral interventions (adults with ASWPD, children/adolescents with DSWPD, and elderly with dementia). Recommendations against the use of melatonin and discrete sleep-promoting medications are provided for demented elderly patients, at a second- and first-tier degree of confidence, respectively. No recommendations were provided for remaining treatments/ populations, due to either insufficient or absent data. Areas where further research is needed are discussed. Citation: Auger RR, Burgess HJ, Emens JS, Deriy LV, Thomas SM, Sharkey KM. Clinical practice guideline for the treatment of intrinsic circadian rhythm sleep-wake disorders: advanced sleep-wake phase disorder (ASWPD), delayed sleep-wake phase disorder (DSWPD), non-24-hour sleep-wake rhythm disorder (N24SWD), and irregular sleep-wake rhythm disorder (ISWRD). An update for 2015. J Clin Sleep Med 2015;11(10):1199–1236. PMID:26414986

Contextualizing the relevance of basic sciences: small-group simulation with debrief for first- and second-year medical students in an integrated curriculum.

PubMed

Ginzburg, Samara B; Brenner, Judith; Cassara, Michael; Kwiatkowski, Thomas; Willey, Joanne M

2017-01-01

There has been a call for increased integration of basic and clinical sciences during preclinical years of undergraduate medical education. Despite the recognition that clinical simulation is an effective pedagogical tool, little has been reported on its use to demonstrate the relevance of basic science principles to the practice of clinical medicine. We hypothesized that simulation with an integrated science and clinical debrief used with early learners would illustrate the importance of basic science principles in clinical diagnosis and management of patients. Small groups of first- and second-year medical students were engaged in a high-fidelity simulation followed by a comprehensive debrief facilitated by a basic scientist and clinician. Surveys including anchored and open-ended questions were distributed at the conclusion of each experience. The majority of the students agreed that simulation followed by an integrated debrief illustrated the clinical relevance of basic sciences (mean ± standard deviation: 93.8% ± 2.9% of first-year medical students; 96.7% ± 3.5% of second-year medical students) and its importance in patient care (92.8% of first-year medical students; 90.4% of second-year medical students). In a thematic analysis of open-ended responses, students felt that these experiences provided opportunities for direct application of scientific knowledge to diagnosis and treatment, improving student knowledge, simulating real-world experience, and developing clinical reasoning, all of which specifically helped them understand the clinical relevance of basic sciences. Small-group simulation followed by a debrief that integrates basic and clinical sciences is an effective means of demonstrating the relationship between scientific fundamentals and patient care for early learners. As more medical schools embrace integrated curricula and seek opportunities for integration, our model is a novel approach that can be utilized.

Large HAWT wake measurement and analysis

NASA Technical Reports Server (NTRS)

Miller, A. H.; Wegley, H. L.; Buck, J. W.

1995-01-01

From the theoretical fluid dynamics point of view, the wake region of a large horizontal-axis wind turbine has been defined and described, and numerical models of wake behavior have been developed. Wind tunnel studies of single turbine wakes and turbine array wakes have been used to verify the theory and further refine the numerical models. However, the effects of scaling, rotor solidity, and topography on wake behavior are questions that remain unanswered. In the wind tunnel studies, turbines were represented by anything from scaled models to tea strainers or wire mesh disks whose solidity was equivalent to that of a typical wind turbine. The scale factor compensation for the difference in Reynolds number between the scale model and an actual turbine is complex, and not typically accounted for. Though it is wise to study the simpler case of wakes in flat topography, which can be easily duplicated in the wind tunnel, current indications are that wind turbine farm development is actually occurring in somewhat more complex terrain. Empirical wake studies using large horizontal-axis wind turbines have not been thoroughly composited, and, therefore, the results have not been applied to the well-developed theory of wake structure. The measurement programs have made use of both in situ sensor systems, such as instrumented towers, and remote sensors, such as kites and tethered, balloonborne anemometers. We present a concise overview of the work that has been performed, including our own, which is based on the philosophy that the MOD-2 turbines are probably their own best detector of both the momentum deficit and the induced turbulence effect downwind. Only the momentum deficit aspects of the wake/machine interactions have been addressed. Both turbine power output deficits and wind energy deficits as measured by the onsite meteorological towers have been analyzed from a composite data set. The analysis has also evidenced certain topographic influences on the operation of

Large HAWT wake measurement and analysis

NASA Astrophysics Data System (ADS)

Miller, A. H.; Wegley, H. L.; Buck, J. W.

1995-05-01

From the theoretical fluid dynamics point of view, the wake region of a large horizontal-axis wind turbine has been defined and described, and numerical models of wake behavior have been developed. Wind tunnel studies of single turbine wakes and turbine array wakes have been used to verify the theory and further refine the numerical models. However, the effects of scaling, rotor solidity, and topography on wake behavior are questions that remain unanswered. In the wind tunnel studies, turbines were represented by anything from scaled models to tea strainers or wire mesh disks whose solidity was equivalent to that of a typical wind turbine. The scale factor compensation for the difference in Reynolds number between the scale model and an actual turbine is complex, and not typically accounted for. Though it is wise to study the simpler case of wakes in flat topography, which can be easily duplicated in the wind tunnel, current indications are that wind turbine farm development is actually occurring in somewhat more complex terrain. Empirical wake studies using large horizontal-axis wind turbines have not been thoroughly composited, and, therefore, the results have not been applied to the well-developed theory of wake structure. The measurement programs have made use of both in situ sensor systems, such as instrumented towers, and remote sensors, such as kites and tethered, balloonborne anemometers. We present a concise overview of the work that has been performed, including our own, which is based on the philosophy that the MOD-2 turbines are probably their own best detector of both the momentum deficit and the induced turbulence effect downwind. Only the momentum deficit aspects of the wake/machine interactions have been addressed. Both turbine power output deficits and wind energy deficits as measured by the onsite meteorological towers have been analyzed from a composite data set. The analysis has also evidenced certain topographic influences on the operation of

Performance and wake conditions of a rotor located in the wake of an obstacle

NASA Astrophysics Data System (ADS)

Naumov, I. V.; Kabardin, I. K.; Mikkelsen, R. F.; Okulov, V. L.; Sørensen, J. N.

2016-09-01

Obstacles like forests, ridges and hills can strongly affect the velocity profile in front of a wind turbine rotor. The present work aims at quantifying the influence of nearby located obstacles on the performance and wake characteristics of a downstream located wind turbine. Here the influence of an obstacle in the form of a cylindrical disk was investigated experimentally in a water flume. A model of a three-bladed rotor, designed using Glauert's optimum theory at a tip speed ratio λ = 5, was placed in the wake of a disk with a diameter close to the one of the rotor. The distance from the disk to the rotor was changed from 4 to 8 rotor diameters, with the vertical distance from the rotor axis varied 0.5 and 1 rotor diameters. The associated turbulent intensity of the incoming flow to the rotor changed 3 to '6% due to the influence of the disk wake. In the experiment, thrust characteristics and associated pulsations as a function of the incoming flow structures were measured by strain gauges. The flow condition in front of the rotor was measured with high temporal accuracy using LDA and power coefficients were determine as function of tip speed ratio for different obstacle positions. Furthermore, PIV measurements were carried out to study the development of the mean velocity deficit profiles of the wake behind the wind turbine model under the influence of the wake generated by the obstacle. By use of regression techniques to fit the velocity profiles it was possible to determine velocity deficits and estimate length scales of the wake attenuation.

Endoplasmic reticulum stress in wake-active neurons progresses with aging.

PubMed

Naidoo, Nirinjini; Zhu, Jingxu; Zhu, Yan; Fenik, Polina; Lian, Jie; Galante, Ray; Veasey, Sigrid

2011-08-01

Fragmentation of wakefulness and sleep are expected outcomes of advanced aging. We hypothesize that wake neurons develop endoplasmic reticulum dyshomeostasis with aging, in parallel with impaired wakefulness. In this series of experiments, we sought to more fully characterize age-related changes in wakefulness and then, in relevant wake neuronal populations, explore functionality and endoplasmic reticulum homeostasis. We report that old mice show greater sleep/wake transitions in the active period with markedly shortened wake periods, shortened latencies to sleep, and less wake time in the subjective day in response to a novel social encounter. Consistent with sleep/wake instability and reduced social encounter wakefulness, orexinergic and noradrenergic wake neurons in aged mice show reduced c-fos response to wakefulness and endoplasmic reticulum dyshomeostasis with increased nuclear translocation of CHOP and GADD34. We have identified an age-related unfolded protein response injury to and dysfunction of wake neurons. It is anticipated that these changes contribute to sleep/wake fragmentation and cognitive impairment in aging. © 2011 The Authors. Aging Cell © 2011 Blackwell Publishing Ltd/Anatomical Society of Great Britain and Ireland.

Analysis of Hypersonic Vehicle Wakes

DTIC Science & Technology

2015-09-17

factor used with viscous Jacobian matrix of left eigenvectors for A R specific gas constant Re Reynolds number Recell cell Reynolds number......focus was shifted to characterizing other wake phenomena. The aerothermal phenomena of interest in the wake include: gas properties, chemical species

Droplet depinning in a wake

NASA Astrophysics Data System (ADS)

Hooshanginejad, Alireza; Lee, Sungyon

2017-03-01

Pinning and depinning of a windswept droplet on a surface is familiar yet deceptively complex for it depends on the interaction of the contact line with the microscopic features of the solid substrate. This physical picture is further compounded when wind of the Reynolds number greater than 100 blows over pinned drops, leading to the boundary layer separation and wake generation. In this Rapid Communication, we incorporate the well-developed ideas of the classical boundary layer to study partially wetting droplets in a wake created by a leader object. Depending on its distance from the leader, the droplet is observed to exhibit drafting, upstream motion, and splitting, due to the wake-induced hydrodynamic coupling that is analogous to drafting of moving bodies. We successfully rationalize the onset of the upstream motion regime using a reduced model that computes the droplet shape governed by the pressure field inside the wake.

Teaching Basic Science Content via Real-World Applications: A College-Level Summer Course in Veterinary Anatomy and Physiology

ERIC Educational Resources Information Center

Maza, Paul; Miller, Allison; Carson, Brian; Hermanson, John

2018-01-01

Learning and retaining science content may be increased by applying the basic science material to real-world situations. Discussing cases with students during lectures and having them participate in laboratory exercises where they apply the science content to practical situations increases students' interest and enthusiasm. A summer course in…

The Transition from Thick to Thin Plate Wake Physics: Whither Vortex Shedding?

NASA Technical Reports Server (NTRS)

Rai, Man Mohan

2016-01-01

The near and very near wake of a flat plate with a circular trailing edge is investigated with data from direct numerical simulations. Computations were performed for six different combinations of the Reynolds numbers based on plate thickness (D) and boundary layer momentum thickness upstream of the trailing edge (theta). Unlike the case of the cylinder, these Reynolds numbers are independent parameters for the flat plate. The separating boundary layers are turbulent in all the cases investigated. One objective of the study is to understand the changes in the wake vortex shedding process as the plate thickness is reduced (increasing theta/D). The value of D varies by a factor of 16 and that of theta by approximately 5 in the computations. Vortex shedding is vigorous in the low theta/D cases with a substantial decrease in shedding intensity in the large theta/D cases. Other shedding characteristics are also significantly altered with increasing theta/D. A visualization of the shedding process in the different cases is provided and discussed. The basic shedding mechanism is explored in depth. The effect of changing theta/D on the time-averaged, near-wake velocity statistics is also discussed. A functional relationship between the shedding frequency and the Reynolds numbers mentioned above is obtained.

Apparatus for Control of Stator Wakes

DTIC Science & Technology

2009-09-18

wake deficit . This has the effect of reducing the blade rate tonal noise of the propulsion rotor. 11 o CN 6 ...upstream of propeller propulsors the sharp wake deficits behind the stators result in unsteady loading and distinguishable peaks in the noise spectra at...trailing edge of a stator blade in order to fill its mean wake deficit to reduce unsteady loading on the rotor blades . Interaction between

Integration of medicine and basic science in dentistry: the role of oral and maxillofacial surgery in the pre-doctoral dental curriculum.

PubMed

Dennis, Matthew J

2010-05-01

It is the premise of this paper that the need for medical and basic science instruction in dentistry will increase over time. However, student and faculty appreciation of the relevance and significance of medicine and basic science to clinical dentistry has been elusive, largely due to difficulties linking biomedical science instruction and clinical dental instruction. The scope of traditional procedure based oral surgery instruction can be expanded in an attempt to bridge the medical science-clinical gap. Topics such as health status evaluation, medical risk assessment, and a variety of other biomedical issues can be presented to students in a way which imparts specific dental meaning to basic medical science in real-life clinical situations. Using didactic and chair side instruction in an oral surgery clinical environment, students are confronted with the need to understand these issues and how they relate to the patients they encounter who present for dental care.

Full-Scale Field Test of Wake Steering

DOE Office of Scientific and Technical Information (OSTI.GOV)

Fleming, Paul; Annoni, Jennifer; Scholbrock, Andrew

Wind farm control, in which turbine controllers are coordinated to improve farmwide performance, is an active field of research. One form of wind farm control is wake steering, in which a turbine is yawed to the inflow to redirect its wake away from downstream turbines. Wake steering has been studied in depth in simulations as well as in wind tunnels and scaled test facilities. This work performs a field test of wake steering on a full-scale turbine. In the campaign, the yaw controller of the turbine has been set to track different yaw misalignment set points while a nacelle-mounted lidarmore » scans the wake at several ranges downwind. The lidar measurements are combined with turbine data, as well as measurements of the inflow made by a highly instrumented meteorological mast. In conclusion, these measurements are then compared to the predictions of a wind farm control-oriented model of wakes.« less

Full-Scale Field Test of Wake Steering

DOE PAGES

Fleming, Paul; Annoni, Jennifer; Scholbrock, Andrew; ...

2017-06-13

Wind farm control, in which turbine controllers are coordinated to improve farmwide performance, is an active field of research. One form of wind farm control is wake steering, in which a turbine is yawed to the inflow to redirect its wake away from downstream turbines. Wake steering has been studied in depth in simulations as well as in wind tunnels and scaled test facilities. This work performs a field test of wake steering on a full-scale turbine. In the campaign, the yaw controller of the turbine has been set to track different yaw misalignment set points while a nacelle-mounted lidarmore » scans the wake at several ranges downwind. The lidar measurements are combined with turbine data, as well as measurements of the inflow made by a highly instrumented meteorological mast. In conclusion, these measurements are then compared to the predictions of a wind farm control-oriented model of wakes.« less

Aeroacoustic and wake measurements on a rotating controlled diffusion blade

NASA Astrophysics Data System (ADS)

Davoudi, Behdad

Aeroacoustic and hot-wire wake measurements have been made for Rotating Controlled Diffusion Blades (RCDBs) configured as a 3 and a 9 blade axial fan. Six cases were identified for the three blade configuration based on its performance curve. Also, six cases corresponding to 6 distinct operating conditions: i) an attached flow, ii) a slightly separated flow, iii) deeply separated flow and three cases in the stall region have been selected for the nine blade configuration. These were examined using a detailed data acquisition program. The detailed results include the wake flow patterns and the associated noise radiation. Turbulence intensities and phase averaged velocity magnitudes have been obtained in the downstream region of the fan to represent the basic flow features for each defined case. A beamforming technique has been utilized to properly measure the radiated sound pressure level (SPL) created by the axial fan. Self-noise signatures of the propagated sound (auto-spectral density), corresponding to the defined cases, have been obtained in the range of 200-8000 Hz. Acoustic data and their links to: i) the physics of the flows, ii) aerodynamic loading and iii) fan rotational speed are presented. A semi-empirical model for trailing edge noise (a portion of the axial fan self-noise) was examined. Wake data (mean velocity and turbulence intensity downstream from the fan blades) were used as experimental inputs to these models. The experimental acoustic data and the semi-empirical results have been compared.

32 CFR 707.10 - Wake illumination light.

Code of Federal Regulations, 2013 CFR

2013-07-01

... 32 National Defense 5 2013-07-01 2013-07-01 false Wake illumination light. 707.10 Section 707.10... RESPECT TO ADDITIONAL STATION AND SIGNAL LIGHTS § 707.10 Wake illumination light. Naval vessels may display a white spot light located near the stern to illuminate the wake. ...

32 CFR 707.10 - Wake illumination light.

Code of Federal Regulations, 2014 CFR

2014-07-01

... 32 National Defense 5 2014-07-01 2014-07-01 false Wake illumination light. 707.10 Section 707.10... RESPECT TO ADDITIONAL STATION AND SIGNAL LIGHTS § 707.10 Wake illumination light. Naval vessels may display a white spot light located near the stern to illuminate the wake. ...

32 CFR 707.10 - Wake illumination light.

Code of Federal Regulations, 2011 CFR

2011-07-01

... 32 National Defense 5 2011-07-01 2011-07-01 false Wake illumination light. 707.10 Section 707.10... RESPECT TO ADDITIONAL STATION AND SIGNAL LIGHTS § 707.10 Wake illumination light. Naval vessels may display a white spot light located near the stern to illuminate the wake. ...

32 CFR 707.10 - Wake illumination light.

Code of Federal Regulations, 2012 CFR

2012-07-01

... 32 National Defense 5 2012-07-01 2012-07-01 false Wake illumination light. 707.10 Section 707.10... RESPECT TO ADDITIONAL STATION AND SIGNAL LIGHTS § 707.10 Wake illumination light. Naval vessels may display a white spot light located near the stern to illuminate the wake. ...

Turbulence Modelling in Wind Turbine Wakes =

NASA Astrophysics Data System (ADS)

Olivares Espinosa, Hugo

With the expansion of the wind energy industry, wind parks have become a common appearance in our landscapes. Owing to restrictions of space or to economic reasons, wind turbines are located close to each other in wind farms. This causes interference problems which reduce the efficiency of the array. In particular, the wind turbine wakes increase the level of turbulence and cause a momentum defect that may lead to an increase of mechanical loads and to a reduction of power output. Thus, it is important for the wind energy industry to predict the characteristics of the turbulence field in the wakes with the purpose of increasing the efficiency of the power extraction. Since this is a phenomenon of intrinsically non-linear nature, it can only be accurately described by the full set of the Navier-Stokes equations. Furthermore, a proper characterization of turbulence cannot be made without resolving the turbulent motions, so neither linearized models nor the widely used Reynolds-Averaged Navier-Stokes model can be employed. Instead, Large-Eddy Simulations (LES) provide a feasible alternative, where the energy containing fluctuations of the velocity field are resolved and the effects of the smaller eddies are modelled through a sub-grid scale component. The objective of this work is the modelling of turbulence in wind turbine wakes in a homogeneous turbulence inflow. A methodology has been developed to fulfill this objective. Firstly, a synthetic turbulence field is introduced into a computational domain where LES are performed to simulate a decaying turbulence flow. Secondly, the Actuator Disk (AD) technique is employed to simulate the effect of a rotor in the incoming flow and produce a turbulent wake. The implementation is carried out in OpenFOAM, an open-source CFD platform, resembling a well documented procedure previously used for wake flow simulations. Results obtained with the proposed methodology are validated by comparing with values obtained from wind tunnel

WAKE ISLAND AIRFIELD TERMINAL, BUILDING 1502 LOOKING EAST WITH PHOTO ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

WAKE ISLAND AIRFIELD TERMINAL, BUILDING 1502 LOOKING EAST WITH PHOTO SCALE CENTERED ON BUILDING (12/30/2008) - Wake Island Airfield, Terminal Building, West Side of Wake Avenue, Wake Island, Wake Island, UM

Comparing offshore wind farm wake observed from satellite SAR and wake model results

NASA Astrophysics Data System (ADS)

Bay Hasager, Charlotte

2014-05-01

Offshore winds can be observed from satellite synthetic aperture radar (SAR). In the FP7 EERA DTOC project, the European Energy Research Alliance project on Design Tools for Offshore Wind Farm Clusters, there is focus on mid- to far-field wind farm wakes. The more wind farms are constructed nearby other wind farms, the more is the potential loss in annual energy production in all neighboring wind farms due to wind farm cluster effects. It is of course dependent upon the prevailing wind directions and wind speed levels, the distance between the wind farms, the wind turbine sizes and spacing. Some knowledge is available within wind farm arrays and in the near-field from various investigations. There are 58 offshore wind farms in the Northern European seas grid connected and in operation. Several of those are spaced near each other. There are several twin wind farms in operation including Nysted-1 and Rødsand-2 in the Baltic Sea, and Horns Rev 1 and Horns Rev 2, Egmond aan Zee and Prinses Amalia, and Thompton 1 and Thompton 2 all in the North Sea. There are ambitious plans of constructing numerous wind farms - great clusters of offshore wind farms. Current investigation of offshore wind farms includes mapping from high-resolution satellite SAR of several of the offshore wind farms in operation in the North Sea. Around 20 images with wind farm wake cases have been retrieved and processed. The data are from the Canadian RADARSAT-1/-2 satellites. These observe in microwave C-band and have been used for ocean surface wind retrieval during several years. The satellite wind maps are valid at 10 m above sea level. The wakes are identified in the raw images as darker areas downwind of the wind farms. In the SAR-based wind maps the wake deficit is found as areas of lower winds downwind of the wind farms compared to parallel undisturbed flow in the flow direction. The wind direction is clearly visible from lee effects and wind streaks in the images. The wind farm wake cases

Using "Basic Principles" to Understand Complex Science: Nicotine Smoke Chemistry and Literature Analogies

ERIC Educational Resources Information Center

Seeman, Jeffrey I.

2005-01-01

The chemical and physical properties of nicotine and its carboxylic acid salts found in tobacco provided as an interesting example to understand basic principles of complex science. The result showed that the experimental data used were inconsistent to the conclusion made, and the transfer of nicotine smoke from tobacco to smoke cannot be…

Wind turbine wake measurement in complex terrain

NASA Astrophysics Data System (ADS)

Hansen, KS; Larsen, GC; Menke, R.; Vasiljevic, N.; Angelou, N.; Feng, J.; Zhu, WJ; Vignaroli, A.; W, W. Liu; Xu, C.; Shen, WZ

2016-09-01

SCADA data from a wind farm and high frequency time series measurements obtained with remote scanning systems have been analysed with focus on identification of wind turbine wake properties in complex terrain. The analysis indicates that within the flow regime characterized by medium to large downstream distances (more than 5 diameters) from the wake generating turbine, the wake changes according to local atmospheric conditions e.g. vertical wind speed. In very complex terrain the wake effects are often “overruled” by distortion effects due to the terrain complexity or topology.

Engaging Oral Health Students in Learning Basic Science Through Assessment That Weaves in Personal Experience.

PubMed

Leadbeatter, Delyse; Gao, Jinlong

2018-04-01

Learning basic science forms an essential foundation for oral health therapy and dentistry, but frequently students perceive it as difficult, dry, and disconnected from clinical practice. This perception is encouraged by assessment methods that reward fact memorization, such as objective examinations. This study evaluated use of a learner-centered assessment portfolio designed to increase student engagement with basic science in an oral health therapy program at the University of Sydney, Australia. The aim of this qualitative study based on focus groups was to investigate students' engagement with basic science courses following introduction of the portfolio. Three assessments were conducted in three subsequent semesters: one based on students' interest in everyday phenomena (one student, for example, explored why she had red hair); the second focussed on scientific evidence and understanding of systemic diseases; and the third explored relations between oral and general health. Students were encouraged to begin with issues from their personal experience or patient care, to focus on what they were curious about, and to ask questions they really cared about. Each student prepared a written report and gave an oral presentation to the entire cohort. After the portfolios were completed, the authors held focus groups with two cohorts of students (N=21) in 2016 and analyzed the results using Zepke's framework for student engagement research. The results showed that the students successfully interweaved personal experience into their studies and that it provided significant motivation for learning. The students described their learning in terms of connection to themselves, their peer community, and their profession. Many additional benefits were identified, from increased student engagement in all courses to appreciation of the relevance of basic science. The findings should encourage dental and allied dental educators to reconsider the effects of assessments and seek

Educating for the 21st-Century Health Care System: An Interdependent Framework of Basic, Clinical, and Systems Sciences.

PubMed

Gonzalo, Jed D; Haidet, Paul; Papp, Klara K; Wolpaw, Daniel R; Moser, Eileen; Wittenstein, Robin D; Wolpaw, Terry

2017-01-01

In the face of a fragmented and poorly performing health care delivery system, medical education in the United States is poised for disruption. Despite broad-based recommendations to better align physician training with societal needs, adaptive change has been slow. Traditionally, medical education has focused on the basic and clinical sciences, largely removed from the newer systems sciences such as population health, policy, financing, health care delivery, and teamwork. In this article, authors examine the current state of medical education with respect to systems sciences and propose a new framework for educating physicians in adapting to and practicing in systems-based environments. Specifically, the authors propose an educational shift from a two-pillar framework to a three-pillar framework where basic, clinical, and systems sciences are interdependent. In this new three-pillar framework, students not only learn the interconnectivity in the basic, clinical, and systems sciences but also uncover relevance and meaning in their education through authentic, value-added, and patient-centered roles as navigators within the health care system. Authors describe the Systems Navigation Curriculum, currently implemented for all students at the Penn State College of Medicine, as an example of this three-pillar educational model. Simple adjustments, such as including occasional systems topics in medical curriculum, will not foster graduates prepared to practice in the 21st-century health care system. Adequate preparation requires an explicit focus on the systems sciences as a vital and equal component of physician education.

Near wakes of advanced turbopropellers

NASA Technical Reports Server (NTRS)

Hanson, D. B.; Patrick, W. P.

1989-01-01

The flow in the wake of a model single rotation Prop-Fan rotor operating in a wind tunnel was traversed with a hot-wire anemometer system designed to determine the 3 periodic velocity components. Special data acquisition and data reduction methods were required to deal with the high data frequency, narrow wakes, and large fluctuating air angles in the tip vortex region. The model tip helical Mach number was 1.17, simulating the cruise condition. Although the flow field is complex, flow features such as viscous velocity defects, vortex sheets, tip vortices, and propagating acoustic pulses are clearly identified with the aid of a simple analytical wake theory.

Ship wakes and their manifestations on the sea surface

NASA Astrophysics Data System (ADS)

Ermakov, Stanislav; Kapustin, Ivan; Kalimulin, Rashid

2013-04-01

Spatial/temporal evolution of turbulence generated by surface ships and the effect of the wake on short wind waves has been studied on the Black Sea and on the Gorky Water Reservoir. Measurements of currents in ship wakes were conducted using an Acoustic Doppler Current Profiler deployed from a motor boat. It was obtained that the temporal/spatial evolution of the wake width could be described approximately by a 0.4-power dependence, and the wake depth remained nearly constant at its initial stage. This allowed one to consider the wake widening as a one-dimensional process. We have developed a simple one-dimensional model of ship wake evolution using a semi-empirical theory of turbulence, and the initial stage of the wake widening (when neglecting dissipation) was described by the equation of turbulent energy balance with the pulse initial condition. Mean circulating currents in the wake zone resulting in the wind wave intensification ("suloi" areas) at the boundaries of the wake were detected in experiment. The asymmetry of the "suloi" bands was observed when the wind was blowing nearly perpendicular to the wake axis. It was shown that the later stage of the wake evolution is characterized by the formation of slick bands at the edges of the wake. The slick bands is a result of the transport of surfactants to the water surface by air bubbles in the wake and their compression due to the mean circulating currents. The work was supported by RFBR (projects 12-05-31237, 11-05-00295), the Program RAN Radiophysics, and by the Russian Government (Grants No. 11.G34.31.0048 and 11.G34.31.0078).

Multiple Near Wake Patterns Behind Annular Rings

NASA Astrophysics Data System (ADS)

Zhang, Jinzhong; Higuchi, Hiroshi; Muzas, Brian K.; Furuya, Shojiro

1996-11-01

Wake interactions behind concentric annular rings at different spacing ratios were experimentally investigated. The flow visualization, laser Doppler velocimetry data and results from the particle tracking velocimetry are presented and discussed. Jets through individual slots merged in multiply-stable, axisymmetric manners. Most flow patterns were persistent unless the flow was strongly disturbed. The vortex interactions from individual annular elements were also axisymmetric in the near wake. This is in contrast to the asymmetric flows observed earlier behind two-dimensional slotted plates (Higuchi et al. J. Aircraft 26 1989, Phys. Fluids 6(1), 1994). The intermediate wake, however, was dominated by large scale, three-dimensional wake motions even at moderate porosity. Onset of the specific flow patterns was associated with the interactions among start-up vortices. Given model geometry, different turbulent structures and mean velocity profiles were observed in the intermediate wake depending on the near wake pattern. *BKM was a NSF-REU Program undergrad. from Princeton U. and SF was from Mitsubishi Heavy Industries. This work was suppoted in part by the Naval Air Warfare Center.

Wind-tunnel measurements in the wakes of structures

NASA Technical Reports Server (NTRS)

Woo, H. G. C.; Peterka, J. A.; Cermak, J. E.

1977-01-01

Detailed measurements of longitudinal mean velocity, turbulence intensity, space correlations, and spectra made in the wake of two rectangular scaled models in simulated atmospheric boundary-layer winds are presented. The model buildings were 1:50 scale models of two trailers. Results of a flow visualization study of the wake geometry are analyzed with some singular point theorems. Two hypothetical flow patterns of the detailed wake geometry are proposed. Some preliminary studies of the vortex wake, effects of the model size, model aspect ratios, and boundary layer characteristics on the decay rate and extent of the wake are also presented and discussed.

Active Wake Redirection Control to Improve Energy Yield (Poster)

DOE Office of Scientific and Technical Information (OSTI.GOV)

Churchfield, M. J.; Fleming, P.; DeGeorge, E.

Wake effects can dramatically reduce the efficiency of waked turbines relative to the unwaked turbines. Wakes can be deflected, or 'redirected,' by applying yaw misalignment to the turbines. Yaw misalignment causes part of the rotor thrust vector to be pointed in the cross-stream direction, deflecting the flow and the wake. Yaw misalignment reduces power production, but the global increase in wind plant power due to decreased wake effect creates a net increase in power production. It is also a fairly simple control idea to implement at existing or new wind plants. We performed high-fidelity computational fluid dynamics simulations of themore » wake flow of the proposed Fishermen's Atlantic City Windfarm (FACW) that predict that under certain waking conditions, wake redirection can increase plant efficiency by 10%. This means that by applying wake redirection control, for a given watersheet area, a wind plant can either produce more power, or the same amount of power can be produced with a smaller watersheet area. With the power increase may come increased loads, though, due to the yaw misalignment. If misalignment is applied properly, or if layered with individual blade pitch control, though, the load increase can be mitigated. In this talk we will discuss the concept of wake redirection through yaw misalignment and present our CFD results of the FACW project. We will also discuss the implications of wake redirection control on annual energy production, and finally we will discuss plans to implement wake redirection control at FACW when it is operational.« less

Wake Turbulence

DOT National Transportation Integrated Search

1997-07-06

THIS IS A SAFETY NOTICE. The guidance contained herein supersedes : the guidance provided in the current edition of Order 7110.65, Air Traffic Control, relating to selected wake turbulence separations and aircraft weight classifications. This Notice ...

Dreaming and waking: similarities and differences revisited.

PubMed

Kahan, Tracey L; LaBerge, Stephen P

2011-09-01

Dreaming is often characterized as lacking high-order cognitive (HOC) skills. In two studies, we test the alternative hypothesis that the dreaming mind is highly similar to the waking mind. Multiple experience samples were obtained from late-night REM sleep and waking, following a systematic protocol described in Kahan (2001). Results indicated that reported dreaming and waking experiences are surprisingly similar in their cognitive and sensory qualities. Concurrently, ratings of dreaming and waking experiences were markedly different on questions of general reality orientation and logical organization (e.g., the bizarreness or typicality of the events, actions, and locations). Consistent with other recent studies (e.g., Bulkeley & Kahan, 2008; Kozmová & Wolman, 2006), experiences sampled from dreaming and waking were more similar with respect to their process features than with respect to their structural features. Copyright © 2010 Elsevier Inc. All rights reserved.

Wake Vortex and Groundwind Meteorological Measurements

DOT National Transportation Integrated Search

1976-05-01

Wake vortex groundwind and meteorological measurements obtained by DOT-TSC at John F. Kennedy (JKF) International Airport have been reduced, analyzed, and correlated with a theoretical vortex transport model. The predictive Wake Vortex Transport Mode...

A multi-instructor, team-based, active-learning exercise to integrate basic and clinical sciences content.

PubMed

Kolluru, Srikanth; Roesch, Darren M; Akhtar de la Fuente, Ayesha

2012-03-12

To introduce a multiple-instructor, team-based, active-learning exercise to promote the integration of basic sciences (pathophysiology, pharmacology, and medicinal chemistry) and clinical sciences in a doctor of pharmacy curriculum. A team-based learning activity that involved pre-class reading assignments, individual-and team-answered multiple-choice questions, and evaluation and discussion of a clinical case, was designed, implemented, and moderated by 3 faculty members from the pharmaceutical sciences and pharmacy practice departments. Student performance was assessed using a multiple-choice examination, an individual readiness assurance test (IRAT), a team readiness assurance test (TRAT), and a subjective, objective, assessment, and plan (SOAP) note. Student attitudes were assessed using a pre- and post-exercise survey instrument. Students' understanding of possible correct treatment strategies for depression improved. Students were appreciative of this true integration of basic sciences knowledge in a pharmacotherapy course and to have faculty members from both disciplines present to answer questions. Mean student score on the on depression module for the examination was 80.4%, indicating mastery of the content. An exercise led by multiple instructors improved student perceptions of the importance of team-based teaching. Integrated teaching and learning may be achieved when instructors from multiple disciplines work together in the classroom using proven team-based, active-learning exercises.

Detailed field test of yaw-based wake steering

DOE Office of Scientific and Technical Information (OSTI.GOV)

Fleming, Paul; Churchfield, Matt; Scholbrock, Andrew

This study describes a detailed field-test campaign to investigate yaw-based wake steering. In yaw-based wake steering, an upstream turbine intentionally misaligns its yaw with respect to the inflow to deflect its wake away from a downstream turbine, with the goal of increasing total power production. In the first phase, a nacelle-mounted scanning lidar was used to verify wake deflection of a misaligned turbine and calibrate wake deflection models. In the second phase, these models were used within a yaw controller to achieve a desired wake deflection. This paper details the experimental design and setup. Lastly, all data collected as partmore » of this field experiment will be archived and made available to the public via the U.S. Department of Energy's Atmosphere to Electrons Data Archive and Portal.« less

Detailed field test of yaw-based wake steering

DOE PAGES

Fleming, Paul; Churchfield, Matt; Scholbrock, Andrew; ...

2016-10-03

This study describes a detailed field-test campaign to investigate yaw-based wake steering. In yaw-based wake steering, an upstream turbine intentionally misaligns its yaw with respect to the inflow to deflect its wake away from a downstream turbine, with the goal of increasing total power production. In the first phase, a nacelle-mounted scanning lidar was used to verify wake deflection of a misaligned turbine and calibrate wake deflection models. In the second phase, these models were used within a yaw controller to achieve a desired wake deflection. This paper details the experimental design and setup. Lastly, all data collected as partmore » of this field experiment will be archived and made available to the public via the U.S. Department of Energy's Atmosphere to Electrons Data Archive and Portal.« less

Impact of Wake Dispersion on Axial Compressor Performance

NASA Technical Reports Server (NTRS)

Hah, Chunill

2017-01-01

Detailed development of wakes and their impact on the performance of a low-speed one and half stage axial compressor are investigated with a large eddy simulation (LES). To investigate effects of wake mixing recovery and wake interaction with the boundary layer of the downstream blade, spacing between the rotor blade and the stator is varied. The calculated LES flow fields based on a fine computational grid are compared with related measurements and analyzed in detail at several radial locations. The current LES calculates the effects of wake recovery very well. The effects of wake recovery vary significantly in the radial direction. Loss generation is higher on the pressure side at the stator exit at both near design and near stall condition. The current investigation indicates that better management of wake development can be achieved for improved compressor performance.

Adult-Rated Oceanography Part 1: A Project Integrating Ocean Sciences into Adult Basic Education Programs.

NASA Astrophysics Data System (ADS)

Cowles, S.; Collier, R.; Torres, M. K.

2004-12-01

Busy scientists seek opportunities to implement education and outreach efforts, but often don't know where to start. One easy and tested method is to form collaborations with federally-funded adult education and adult literacy programs. These programs exist in every U.S. state and territory and serve underrepresented populations through such major initiatives as adult basic education, adult secondary education (and GED preparation), and English language acquisition. These students are workers, consumers, voters, parents, grandparents, and members of every community. They have specific needs that are often overlooked in outreach activities. This presentation will describe the steps by which the Oregon Ocean Science and Math Collaborative program was developed. It is based on a partnership between the Oregon Department of Community Colleges and Workforce Development, Oregon State University College of Oceanic and Atmospheric Sciences, Oregon Sea Grant, and the OSU Hatfield Marine Science Center. It includes professional development through instructor institutes; teachers at sea and informal education opportunities; curriculum and web site development. Through the partnership described here, instructors in adult basic education programs participate in a yearlong experience in which they develop, test, and adapt innovative instructional strategies to meet the specific needs of adult learners. This, in turn, leads to new prospects for study in the areas of ocean science and math and introduces non-academic careers in marine science to a new community. Working directly with instructors, we have identified expertise level, instructional environment, instructor background and current teaching strategies used to address science literacy and numeracy goals of the adult learners in the State of Oregon. Preliminary evaluation of our ongoing project in meeting these goals will be discussed. These efforts contribute to national goals of science literacy for all, by providing

Stability analysis of shallow wake flows

NASA Astrophysics Data System (ADS)

Kolyshkin, A. A.; Ghidaoui, M. S.

2003-11-01

Experimentally observed periodic structures in shallow (i.e. bounded) wake flows are believed to appear as a result of hydrodynamic instability. Previously published studies used linear stability analysis under the rigid-lid assumption to investigate the onset of instability of wakes in shallow water flows. The objectives of this paper are: (i) to provide a preliminary assessment of the accuracy of the rigid-lid assumption; (ii) to investigate the influence of the shape of the base flow profile on the stability characteristics; (iii) to formulate the weakly nonlinear stability problem for shallow wake flows and show that the evolution of the instability is governed by the Ginzburg Landau equation; and (iv) to establish the connection between weakly nonlinear analysis and the observed flow patterns in shallow wake flows which are reported in the literature. It is found that the relative error in determining the critical value of the shallow wake stability parameter induced by the rigid-lid assumption is below 10% for the practical range of Froude number. In addition, it is shown that the shape of the velocity profile has a large influence on the stability characteristics of shallow wakes. Starting from the rigid-lid shallow-water equations and using the method of multiple scales, an amplitude evolution equation for the most unstable mode is derived. The resulting equation has complex coefficients and is of Ginzburg Landau type. An example calculation of the complex coefficients of the Ginzburg Landau equation confirms the existence of a finite equilibrium amplitude, where the unstable mode evolves with time into a limit-cycle oscillation. This is consistent with flow patterns observed by Ingram & Chu (1987), Chen & Jirka (1995), Balachandar et al. (1999), and Balachandar & Tachie (2001). Reasonable agreement is found between the saturation amplitude obtained from the Ginzburg Landau equation under some simplifying assumptions and the numerical data of Grubi

Secure Wake-Up Scheme for WBANs

NASA Astrophysics Data System (ADS)

Liu, Jing-Wei; Ameen, Moshaddique Al; Kwak, Kyung-Sup

Network life time and hence device life time is one of the fundamental metrics in wireless body area networks (WBAN). To prolong it, especially those of implanted sensors, each node must conserve its energy as much as possible. While a variety of wake-up/sleep mechanisms have been proposed, the wake-up radio potentially serves as a vehicle to introduce vulnerabilities and attacks to WBAN, eventually resulting in its malfunctions. In this paper, we propose a novel secure wake-up scheme, in which a wake-up authentication code (WAC) is employed to ensure that a BAN Node (BN) is woken up by the correct BAN Network Controller (BNC) rather than unintended users or malicious attackers. The scheme is thus particularly implemented by a two-radio architecture. We show that our scheme provides higher security while consuming less energy than the existing schemes.

Dissipation of Turbulence in the Wake of a Wind Turbine

NASA Astrophysics Data System (ADS)

Lundquist, J. K.; Bariteau, L.

2015-02-01

The wake of a wind turbine is characterized by increased turbulence and decreased wind speed. Turbines are generally deployed in large groups in wind farms, and so the behaviour of an individual wake as it merges with other wakes and propagates downwind is critical in assessing wind-farm power production. This evolution depends on the rate of turbulence dissipation in the wind-turbine wake, which has not been previously quantified in field-scale measurements. In situ measurements of winds and turbulence dissipation from the wake region of a multi-MW turbine were collected using a tethered lifting system (TLS) carrying a payload of high-rate turbulence probes. Ambient flow measurements were provided from sonic anemometers on a meteorological tower located near the turbine. Good agreement between the tower measurements and the TLS measurements was established for a case without a wind-turbine wake. When an operating wind turbine is located between the tower and the TLS so that the wake propagates to the TLS, the TLS measures dissipation rates one to two orders of magnitude higher in the wake than outside of the wake. These data, collected between two and three rotor diameters downwind of the turbine, document the significant enhancement of turbulent kinetic energy dissipation rate within the wind-turbine wake. These wake measurements suggest that it may be useful to pursue modelling approaches that account for enhanced dissipation. Comparisons of wake and non-wake dissipation rates to mean wind speed, wind-speed variance, and turbulence intensity are presented to facilitate the inclusion of these measurements in wake modelling schemes.

Wind tunnel measurements for dispersion modelling of vehicle wakes

NASA Astrophysics Data System (ADS)

Carpentieri, Matteo; Kumar, Prashant; Robins, Alan

2012-12-01

Wind tunnel measurements downwind of reduced scale car models have been made to study the wake regions in detail, test the usefulness of existing vehicle wake models, and draw key information needed for dispersion modelling in vehicle wakes. The experiments simulated a car moving in still air. This is achieved by (i) the experimental characterisation of the flow, turbulence and concentration fields in both the near and far wake regions, (ii) the preliminary assessment of existing wake models using the experimental database, and (iii) the comparison of previous field measurements in the wake of a real diesel car with the wind tunnel measurements. The experiments highlighted very large gradients of velocities and concentrations existing, in particular, in the near-wake. Of course, the measured fields are strongly dependent on the geometry of the modelled vehicle and a generalisation for other vehicles may prove to be difficult. The methodology applied in the present study, although improvable, could constitute a first step towards the development of mathematical parameterisations. Experimental results were also compared with the estimates from two wake models. It was found that they can adequately describe the far-wake of a vehicle in terms of velocities, but a better characterisation in terms of turbulence and pollutant dispersion is needed. Parameterised models able to predict velocity and concentrations with fine enough details at the near-wake scale do not exist.

Quantitative three-dimensional low-speed wake surveys

NASA Technical Reports Server (NTRS)

Brune, G. W.

1992-01-01

Theoretical and practical aspects of conducting three-dimensional wake measurements in large wind tunnels are reviewed with emphasis on applications in low-speed aerodynamics. Such quantitative wake surveys furnish separate values for the components of drag, such as profile drag and induced drag, but also measure lift without the use of a balance. In addition to global data, details of the wake flowfield as well as spanwise distributions of lift and drag are obtained. The paper demonstrates the value of this measurement technique using data from wake measurements conducted by Boeing on a variety of low-speed configurations including the complex high-lift system of a transport aircraft.

Basic science breaks through: New therapeutic advances in Parkinson's disease.

PubMed

Brundin, Patrik; Atkin, Graham; Lamberts, Jennifer T

2015-09-15

Parkinson's disease (PD) is the second most common neurodegenerative disease and is typically associated with progressive motor dysfunction, although PD patients also exhibit a variety of non-motor symptoms. The neuropathological hallmark of PD is intraneuronal inclusions containing primarily α-Synuclein (α-Syn), and several lines of evidence point to α-Syn as a key contributor to disease progression. Thus, basic research in the field of PD is largely focused on understanding the pathogenic properties of α-Syn. Over the past 2 y, these studies helped to identify several novel therapeutic strategies that have the potential to slow PD progression; such strategies include sequestration of extracellular α-Syn through immunotherapy, reduction of α-Syn multimerization or intracellular toxicity, and attenuation of the neuroinflammatory response. This review describes these and other putative therapeutic strategies, together with the basic science research that led to their identification. The current breadth of novel targets for the treatment of PD warrants cautious optimism in the fight against this devastating disease. © 2015 International Parkinson and Movement Disorder Society.

Developing a complex systems perspective for medical education to facilitate the integration of basic science and clinical medicine.

PubMed

Aron, David C

2017-04-01

The purpose of medical education is to produce competent and capable professional practitioners who can combine the art and science of medicine. Moreover, this process must prepare individuals to practise in a field in which knowledge is increasing and the contexts in which that knowledge is applied are changing in unpredictable ways. The 'basic sciences' are important in the training of a physician. The goal of basic science training is to learn it in a way that the material can be applied in practice. Much effort has been expended to integrate basic science and clinical training, while adding many other topics to the medical curriculum. This effort has been challenging. The aims of the paper are (1) to propose a unifying conceptual framework that facilitates knowledge integration among all levels of living systems from cell to society and (2) illustrate the organizing principles with two examples of the framework in action - cybernetic systems (with feedback) and distributed robustness. Literature related to hierarchical and holarchical frameworks was reviewed. An organizing framework derived from living systems theory and spanning the range from molecular biology to health systems management was developed. The application of cybernetic systems to three levels (regulation of pancreatic beta cell production of insulin, physician adjustment of medication for glycaemic control and development and action of performance measures for diabetes care) was illustrated. Similarly distributed robustness was illustrated by the DNA damage response system and principles underlying patient safety. Each of the illustrated organizing principles offers a means to facilitate the weaving of basic science and clinical medicine throughout the course of study. The use of such an approach may promote systems thinking, which is a core competency for effective and capable medical practice. Published 2016. This article is a U.S. Government work and is in the public domain in the USA.

Wind tunnel measurements of wake structure and wind farm power for actuator disk model wind turbines in yaw

NASA Astrophysics Data System (ADS)

Howland, Michael; Bossuyt, Juliaan; Kang, Justin; Meyers, Johan; Meneveau, Charles

2016-11-01

Reducing wake losses in wind farms by deflecting the wakes through turbine yawing has been shown to be a feasible wind farm control approach. In this work, the deflection and morphology of wakes behind a wind turbine operating in yawed conditions are studied using wind tunnel experiments of a wind turbine modeled as a porous disk in a uniform inflow. First, by measuring velocity distributions at various downstream positions and comparing with prior studies, we confirm that the nonrotating wind turbine model in yaw generates realistic wake deflections. Second, we characterize the wake shape and make observations of what is termed a "curled wake," displaying significant spanwise asymmetry. Through the use of a 100 porous disk micro-wind farm, total wind farm power output is studied for a variety of yaw configurations. Strain gages on the tower of the porous disk models are used to measure the thrust force as a substitute for turbine power. The frequency response of these measurements goes up to the natural frequency of the model and allows studying the spatiotemporal characteristics of the power output under the effects of yawing. This work has been funded by the National Science Foundation (Grants CBET-113380 and IIA-1243482, the WINDINSPIRE project). JB and JM are supported by ERC (ActiveWindFarms, Grant No. 306471).

Peer-assisted learning: filling the gaps in basic science education for preclinical medical students.

PubMed

Sammaraiee, Yezen; Mistry, Ravi D; Lim, Julian; Wittner, Liora; Deepak, Shantal; Lim, Gareth

2016-09-01

In contrast to peer-assisted learning (PAL) in clinical training, there is scant literature on the efficacy of PAL during basic medical sciences teaching for preclinical students. A group of senior medical students aimed to design and deliver clinically oriented small-group tutorials after every module in the preclinical curriculum at a United Kingdom medical school. Twenty tutorials were delivered by senior students throughout the year to first- and second-year students. A baseline questionnaire was delivered to inform the development of the program followed by an end-point questionnaire the next year (n = 122). Quizzes were administered before and after five separate tutorials to assess changes in mean student scores. Additionally, each tutorial was evaluated via a questionnaire for participants (n = 949). All five posttutorial quizzes showed a significant improvement in mean student score (P < 0.05). Questionnaires showed students found the program to be relevant and useful for revision purposes and appreciated how tutorials contextualized basic science to clinical medicine. Students appreciated the interactive nature of the sessions and found receiving personalized feedback about their learning and consolidating information with someone familiar with the material to be useful. With the inclusion of the program, students felt there were now an adequate number of tutorials during the year. In conclusion, this study shows that senior medical students can design and deliver a program that adds value to the mostly lecture-based formal preclinical curriculum. We hope that our study can prompt further work to explore the effect of PAL on the teaching of basic sciences during preclinical studies. Copyright © 2016 The American Physiological Society.

Wake vortex separation standards : analysis methods

DOT National Transportation Integrated Search

1997-01-01

Wake vortex separation standards are used to prevent hazardous wake vortex encounters. A "safe" separation model can be used to assess the safety of proposed changes in the standards. A safe separation model can be derived from an encounter hazard mo...

Interaction of Aircraft Wakes From Laterally Spaced Aircraft

NASA Technical Reports Server (NTRS)

Proctor, Fred H.

2009-01-01

Large Eddy Simulations are used to examine wake interactions from aircraft on closely spaced parallel paths. Two sets of experiments are conducted, with the first set examining wake interactions out of ground effect (OGE) and the second set for in ground effect (IGE). The initial wake field for each aircraft represents a rolled-up wake vortex pair generated by a B-747. Parametric sets include wake interactions from aircraft pairs with lateral separations of 400, 500, 600, and 750 ft. The simulation of a wake from a single aircraft is used as baseline. The study shows that wake vortices from either a pair or a formation of B-747 s that fly with very close lateral spacing, last longer than those from an isolated B-747. For OGE, the inner vortices between the pair of aircraft, ascend, link and quickly dissipate, leaving the outer vortices to decay and descend slowly. For the IGE scenario, the inner vortices ascend and last longer, while the outer vortices decay from ground interaction at a rate similar to that expected from an isolated aircraft. Both OGE and IGE scenarios produce longer-lasting wakes for aircraft with separations less than 600 ft. The results are significant because concepts to increase airport capacity have been proposed that assume either aircraft formations and/or aircraft pairs landing on very closely spaced runways.

EEG microstates of wakefulness and NREM sleep.

PubMed

Brodbeck, Verena; Kuhn, Alena; von Wegner, Frederic; Morzelewski, Astrid; Tagliazucchi, Enzo; Borisov, Sergey; Michel, Christoph M; Laufs, Helmut

2012-09-01

EEG-microstates exploit spatio-temporal EEG features to characterize the spontaneous EEG as a sequence of a finite number of quasi-stable scalp potential field maps. So far, EEG-microstates have been studied mainly in wakeful rest and are thought to correspond to functionally relevant brain-states. Four typical microstate maps have been identified and labeled arbitrarily with the letters A, B, C and D. We addressed the question whether EEG-microstate features are altered in different stages of NREM sleep compared to wakefulness. 32-channel EEG of 32 subjects in relaxed wakefulness and NREM sleep was analyzed using a clustering algorithm, identifying the most dominant amplitude topography maps typical of each vigilance state. Fitting back these maps into the sleep-scored EEG resulted in a temporal sequence of maps for each sleep stage. All 32 subjects reached sleep stage N2, 19 also N3, for at least 1 min and 45 s. As in wakeful rest we found four microstate maps to be optimal in all NREM sleep stages. The wake maps were highly similar to those described in the literature for wakefulness. The sleep stage specific map topographies of N1 and N3 sleep showed a variable but overall relatively high degree of spatial correlation to the wake maps (Mean: N1 92%; N3 87%). The N2 maps were the least similar to wake (mean: 83%). Mean duration, total time covered, global explained variance and transition probabilities per subject, map and sleep stage were very similar in wake and N1. In wake, N1 and N3, microstate map C was most dominant w.r.t. global explained variance and temporal presence (ratio total time), whereas in N2 microstate map B was most prominent. In N3, the mean duration of all microstate maps increased significantly, expressed also as an increase in transition probabilities of all maps to themselves in N3. This duration increase was partly--but not entirely--explained by the occurrence of slow waves in the EEG. The persistence of exactly four main microstate

Synaptic plasticity modulates autonomous transitions between waking and sleep states: Insights from a Morris-Lecar model

NASA Astrophysics Data System (ADS)

Ciszak, Marzena; Bellesi, Michele

2011-12-01

The transitions between waking and sleep states are characterized by considerable changes in neuronal firing. During waking, neurons fire tonically at irregular intervals and a desynchronized activity is observed at the electroencephalogram. This activity becomes synchronized with slow wave sleep onset when neurons start to oscillate between periods of firing (up-states) and periods of silence (down-states). Recently, it has been proposed that the connections between neurons undergo potentiation during waking, whereas they weaken during slow wave sleep. Here, we propose a dynamical model to describe basic features of the autonomous transitions between such states. We consider a network of coupled neurons in which the strength of the interactions is modulated by synaptic long term potentiation and depression, according to the spike time-dependent plasticity rule (STDP). The model shows that the enhancement of synaptic strength between neurons occurring in waking increases the propensity of the network to synchronize and, conversely, desynchronization appears when the strength of the connections become weaker. Both transitions appear spontaneously, but the transition from sleep to waking required a slight modification of the STDP rule with the introduction of a mechanism which becomes active during sleep and changes the proportion between potentiation and depression in accordance with biological data. At the neuron level, transitions from desynchronization to synchronization and vice versa can be described as a bifurcation between two different states, whose dynamical regime is modulated by synaptic strengths, thus suggesting that transition from a state to an another can be determined by quantitative differences between potentiation and depression.

Application of laser velocimetry to aircraft wake-vortex measurements

NASA Technical Reports Server (NTRS)

Ciffone, D. L.; Orloff, K. L.

1977-01-01

The theory and use of a laser velocimeter that makes simultaneous measurements of vertical and longitudinal velocities while rapidly scanning a flow field laterally are described, and its direct application to trailing wake-vortex research is discussed. Pertinent measurements of aircraft wake-vortex velocity distributions obtained in a wind tunnel and water towing tank are presented. The utility of the velocimeter to quantitatively assess differences in wake velocity distributions due to wake dissipating devices and span loading changes on the wake-generating model is also demonstrated.

Dissipation of turbulence in the wake of a wind turbine

DOE Office of Scientific and Technical Information (OSTI.GOV)

Lundquist, J. K.; Bariteau, L.

The wake of a wind turbine is characterized by increased turbulence and decreased wind speed. Turbines are generally deployed in large groups in wind farms, and so the behaviour of an individual wake as it merges with other wakes and propagates downwind is critical in assessing wind-farm power production. This evolution depends on the rate of turbulence dissipation in the wind-turbine wake, which has not been previously quantified in field-scale measurements. In situ measurements of winds and turbulence dissipation from the wake region of a multi-MW turbine were collected using a tethered lifting system (TLS) carrying a payload of high-ratemore » turbulence probes. Ambient flow measurements were provided from sonic anemometers on a meteorological tower located near the turbine. Good agreement between the tower measurements and the TLS measurements was established for a case without a wind-turbine wake. When an operating wind turbine is located between the tower and the TLS so that the wake propagates to the TLS, the TLS measures dissipation rates one to two orders of magnitude higher in the wake than outside of the wake. These data, collected between two and three rotor diameters D downwind of the turbine, document the significant enhancement of turbulent kinetic energy dissipation rate within the wind-turbine wake. These wake measurements suggest that it may be useful to pursue modelling approaches that account for enhanced dissipation. Furthermore. comparisons of wake and non-wake dissipation rates to mean wind speed, wind-speed variance, and turbulence intensity are presented to facilitate the inclusion of these measurements in wake modelling schemes.« less

Dissipation of turbulence in the wake of a wind turbine

DOE PAGES

Lundquist, J. K.; Bariteau, L.

2014-11-06

The wake of a wind turbine is characterized by increased turbulence and decreased wind speed. Turbines are generally deployed in large groups in wind farms, and so the behaviour of an individual wake as it merges with other wakes and propagates downwind is critical in assessing wind-farm power production. This evolution depends on the rate of turbulence dissipation in the wind-turbine wake, which has not been previously quantified in field-scale measurements. In situ measurements of winds and turbulence dissipation from the wake region of a multi-MW turbine were collected using a tethered lifting system (TLS) carrying a payload of high-ratemore » turbulence probes. Ambient flow measurements were provided from sonic anemometers on a meteorological tower located near the turbine. Good agreement between the tower measurements and the TLS measurements was established for a case without a wind-turbine wake. When an operating wind turbine is located between the tower and the TLS so that the wake propagates to the TLS, the TLS measures dissipation rates one to two orders of magnitude higher in the wake than outside of the wake. These data, collected between two and three rotor diameters D downwind of the turbine, document the significant enhancement of turbulent kinetic energy dissipation rate within the wind-turbine wake. These wake measurements suggest that it may be useful to pursue modelling approaches that account for enhanced dissipation. Furthermore. comparisons of wake and non-wake dissipation rates to mean wind speed, wind-speed variance, and turbulence intensity are presented to facilitate the inclusion of these measurements in wake modelling schemes.« less

Wake Vortex Avoidance System and Method

NASA Technical Reports Server (NTRS)

Shams, Qamar A. (Inventor); Zuckerwar, Allan J. (Inventor); Knight, Howard K. (Inventor)

2017-01-01

A wake vortex avoidance system includes a microphone array configured to detect low frequency sounds. A signal processor determines a geometric mean coherence based on the detected low frequency sounds. A display displays wake vortices based on the determined geometric mean coherence.

Lidar-based wake tracking for closed-loop wind farm control

NASA Astrophysics Data System (ADS)

Raach, Steffen; Schlipf, David; Cheng, Po Wen

2016-09-01

This work presents two advancements towards closed-loop wake redirecting of a wind turbine. First, a model-based estimation approach is presented which uses a nacelle-based lidar system facing downwind to obtain information about the wake. A reduced order wake model is described which is then used in the estimation to track the wake. The tracking is demonstrated with lidar measurement data from an offshore campaign and with simulated lidar data from a SOWFA simulation. Second, a controller for closed-loop wake steering is presented. It uses the wake tracking information to set the yaw actuator of the wind turbine to redirect the wake to a desired position. Altogether, this paper aims to present the concept of closed-loop wake redirecting and gives a possible solution to it.

Turbulent Plane Wakes Subjected to Successive Strains

NASA Technical Reports Server (NTRS)

Rogers, Michael M.

2003-01-01

Six direct numerical simulations of turbulent time-evolving strained plane wakes have been examined to investigate the response of a wake to successive irrotational plane strains of opposite sign. The orientation of the applied strain field has been selected so that the flow is the time-developing analogue of a spatially developing wake evolving in the presence of either a favourable or an adverse streamwise pressure gradient. The magnitude of the applied strain rate a is constant in time t until the total strain e(sup at) reaches about four. At this point, a new simulation is begun with the sign of the applied strain being reversed (the original simulation is continued as well). When the total strain is reduced back to its original value of one, yet another simulation is begun with the sign of the strain being reversed again back to its original sign. This process is done for both initially "favourable" and initially "adverse" strains, providing simulations for each of these strain types from three different initial conditions. The evolution of the wake mean velocity deficit and width is found to be very similar for all the adversely strained cases, with both measures rapidly achieving exponential growth at the rate associated with the cross-stream expansive strain e(sup at). In the "favourably" strained cases, the wake widths approach a constant and the velocity deficits ultimately decay rapidly as e(sup -2at). Although all three of these cases do exhibit the same asymptotic exponential behaviour, the time required to achieve this is longer for the cases that have been previously adversely strained (by at approx. equals 1). These simulations confirm the generality of the conclusions drawn in Rogers (2002) regarding the response of plane wakes to strain. The evolution of strained wakes is not consistent with the predictions of classical self-similar analysis; a more general equilibrium similarity solution is required to describe the results. At least for the cases

[Discussion on several basic issues of acupuncture-moxibustion science].

PubMed

Wang, Guangjun

2016-10-12

Nine basic issues on acupuncture-moxibustion science are discussed in this paper. The author believes those include the universal property of acupoints,the placebo effect of acupuncture and moxibustion,the continuous transmission of acupuncture information,the factors of the effects such as growth as well as acquired shape and properties,the classification evidence of acupoint function,the compatibility of acupoints,the change of functional state of acupoint and deqi . The universal property of acupoints means whether there is identical position of acupoint among different ethnic groups. The continuous transmission of acupuncture information is seen as whether the delivery which mainly shows as diffusion maintains active in special region and situation. The classification evidence of acupoint function refers to if there exists universal biological basis.

Retention of knowledge and perceived relevance of basic sciences in an integrated case-based learning (CBL) curriculum

PubMed Central

2013-01-01

Background Knowledge and understanding of basic biomedical sciences remain essential to medical practice, particularly when faced with the continual advancement of diagnostic and therapeutic modalities. Evidence suggests, however, that retention tends to atrophy across the span of an average medical course and into the early postgraduate years, as preoccupation with clinical medicine predominates. We postulated that perceived relevance demonstrated through applicability to clinical situations may assist in retention of basic science knowledge. Methods To test this hypothesis in our own medical student cohort, we administered a paper-based 50 MCQ assessment to a sample of students from Years 2 through 5. Covariates pertaining to demographics, prior educational experience, and the perceived clinical relevance of each question were also collected. Results A total of 232 students (Years 2–5, response rate 50%) undertook the assessment task. This sample had comparable demographic and performance characteristics to the whole medical school cohort. In general, discipline-specific and overall scores were better for students in the latter years of the course compared to those in Year 2; male students and domestic students tended to perform better than their respective counterparts in certain disciplines. In the clinical years, perceived clinical relevance was significantly and positively correlated with item performance. Conclusions This study suggests that perceived clinical relevance is a contributing factor to the retention of basic science knowledge and behoves curriculum planners to make clinical relevance a more explicit component of applied science teaching throughout the medical course. PMID:24099045

Vortex wakes of a flapping foil in a flowing soap film

NASA Astrophysics Data System (ADS)

Schnipper, Teis; Andersen, Anders; Bohr, Tomas

2008-11-01

We present an experimental study of an oscillating, symmetric foil in a vertically flowing soap film. By varying frequency and amplitude of the oscillation we explore and visualize a variety of wake structures, including von Kármán wake, reverse von Kármán wake, 2P wake, and 2P+2S wake. We characterize the transition from the von Kármán wake (drag) to the reverse von Kármán wake (thrust) and discuss the results in relation to fish swimming. We visualize the time evolution of the vortex shedding in detail, identify the origins of the vortices comprising the wake, and propose a simple model to account for the transition from von Kármán like wakes to more exotic wake structures.

Separation of Lift-Generated Vortex Wakes Into Two Diverging Parts

NASA Technical Reports Server (NTRS)

Rossow, Vernon J.; Brown, Anthony P.

2010-01-01

As part of an ongoing study of the spreading rate of lift-generated vortex wakes, the present investigation considers possible reasons as to why segments of lift-generated wakes sometimes depart from the main part of the wake to move rapidly in either an upward or downward direction. It is assumed that deficiencies or enhancements of the lift carry over across the fuselage-shrouded wing are the driving mechanism for departures of wake-segments. The computations presented first indicate that upwardly departing wake segments that were observed and photographed could have been produced by a deficiency in lift carryover across the fuselage-shrouded part of the wing. Computations made of idealized vortex wakes indicate that upward departure of a wake segment requires a centerline reduction in the span loading of 70% or more, whether the engines are at idle or robust thrust. Similarly, it was found that downward departure of wake segments is produced when the lift over the center part of the wing is enhanced. However, it was also found that downward departures do not occur without the presence of robust engine-exhaust streams (i.e., engines must NOT be at idle). In those cases, downward departures of a wake segment occurs when the centerline value of the loading is enhanced by any amount between about 10% to 100%. Observations of condensation trails indicate that downward departure of wake segments is rare. Upward departures of wake segments appears to be more common but still rare. A study to determine the part of the aircraft that causes wake departures has not been carried out. However, even though departures of wake segments rarely occur, some aircraft do regularly shed these wake structures. If aircraft safety is to be assured to a high degree of reliability, and a solution for eliminating them is not implemented, existing guidelines for the avoidance of vortex wakes [1,3] may need to be broadened to include possible increases in wake sizes caused by vertical

Characterization of forced response of density stratified reacting wake

NASA Astrophysics Data System (ADS)

Pawar, Samadhan A.; Sujith, Raman I.; Emerson, Benjamin; Lieuwen, Tim

2018-02-01

The hydrodynamic stability of a reacting wake depends primarily on the density ratio [i.e., ratio of unburnt gas density (ρu) to burnt gas density (ρb)] of the flow across the wake. The variation of the density ratio from high to low value, keeping ρ u / ρ b > 1 , transitions dynamical characteristics of the reacting wake from a linearly globally stable (or convectively unstable) to a globally unstable mode. In this paper, we propose a framework to analyze the effect of harmonic forcing on the deterministic and synchronization characteristics of reacting wakes. Using the recurrence quantification analysis of the forced wake response, we show that the deterministic behaviour of the reacting wake increases as the amplitude of forcing is increased. Furthermore, for different density ratios, we found that the synchronization of the top and bottom branches of the wake with the forcing signal is dependent on whether the mean frequency of the natural oscillations of the wake (fn) is lesser or greater than the frequency of external forcing (ff). We notice that the response of both branches (top and bottom) of the reacting wake to the external forcing is asymmetric and symmetric for the low and high density ratios, respectively. Furthermore, we characterize the phase-locking behaviour between the top and bottom branches of the wake for different values of density ratios. We observe that an increase in the density ratio results in a gradual decrease in the relative phase angle between the top and bottom branches of the wake, which leads to a change in the vortex shedding pattern from a sinuous (anti-phase) to a varicose (in-phase) mode of the oscillations.

Optimization Under Uncertainty for Wake Steering Strategies

DOE Office of Scientific and Technical Information (OSTI.GOV)

Quick, Julian; Annoni, Jennifer; King, Ryan N.

Here, wind turbines in a wind power plant experience significant power losses because of aerodynamic interactions between turbines. One control strategy to reduce these losses is known as 'wake steering,' in which upstream turbines are yawed to direct wakes away from downstream turbines. Previous wake steering research has assumed perfect information, however, there can be significant uncertainty in many aspects of the problem, including wind inflow and various turbine measurements. Uncertainty has significant implications for performance of wake steering strategies. Consequently, the authors formulate and solve an optimization under uncertainty (OUU) problem for finding optimal wake steering strategies in themore » presence of yaw angle uncertainty. The OUU wake steering strategy is demonstrated on a two-turbine test case and on the utility-scale, offshore Princess Amalia Wind Farm. When we accounted for yaw angle uncertainty in the Princess Amalia Wind Farm case, inflow-direction-specific OUU solutions produced between 0% and 1.4% more power than the deterministically optimized steering strategies, resulting in an overall annual average improvement of 0.2%. More importantly, the deterministic optimization is expected to perform worse and with more downside risk than the OUU result when realistic uncertainty is taken into account. Additionally, the OUU solution produces fewer extreme yaw situations than the deterministic solution.« less

Optimization Under Uncertainty for Wake Steering Strategies

NASA Astrophysics Data System (ADS)

Quick, Julian; Annoni, Jennifer; King, Ryan; Dykes, Katherine; Fleming, Paul; Ning, Andrew

2017-05-01

Wind turbines in a wind power plant experience significant power losses because of aerodynamic interactions between turbines. One control strategy to reduce these losses is known as “wake steering,” in which upstream turbines are yawed to direct wakes away from downstream turbines. Previous wake steering research has assumed perfect information, however, there can be significant uncertainty in many aspects of the problem, including wind inflow and various turbine measurements. Uncertainty has significant implications for performance of wake steering strategies. Consequently, the authors formulate and solve an optimization under uncertainty (OUU) problem for finding optimal wake steering strategies in the presence of yaw angle uncertainty. The OUU wake steering strategy is demonstrated on a two-turbine test case and on the utility-scale, offshore Princess Amalia Wind Farm. When we accounted for yaw angle uncertainty in the Princess Amalia Wind Farm case, inflow-direction-specific OUU solutions produced between 0% and 1.4% more power than the deterministically optimized steering strategies, resulting in an overall annual average improvement of 0.2%. More importantly, the deterministic optimization is expected to perform worse and with more downside risk than the OUU result when realistic uncertainty is taken into account. Additionally, the OUU solution produces fewer extreme yaw situations than the deterministic solution.

Optimization Under Uncertainty for Wake Steering Strategies

DOE PAGES

Quick, Julian; Annoni, Jennifer; King, Ryan N.; ...

2017-06-13

Here, wind turbines in a wind power plant experience significant power losses because of aerodynamic interactions between turbines. One control strategy to reduce these losses is known as 'wake steering,' in which upstream turbines are yawed to direct wakes away from downstream turbines. Previous wake steering research has assumed perfect information, however, there can be significant uncertainty in many aspects of the problem, including wind inflow and various turbine measurements. Uncertainty has significant implications for performance of wake steering strategies. Consequently, the authors formulate and solve an optimization under uncertainty (OUU) problem for finding optimal wake steering strategies in themore » presence of yaw angle uncertainty. The OUU wake steering strategy is demonstrated on a two-turbine test case and on the utility-scale, offshore Princess Amalia Wind Farm. When we accounted for yaw angle uncertainty in the Princess Amalia Wind Farm case, inflow-direction-specific OUU solutions produced between 0% and 1.4% more power than the deterministically optimized steering strategies, resulting in an overall annual average improvement of 0.2%. More importantly, the deterministic optimization is expected to perform worse and with more downside risk than the OUU result when realistic uncertainty is taken into account. Additionally, the OUU solution produces fewer extreme yaw situations than the deterministic solution.« less

Crosswind Shear Gradient Affect on Wake Vortices

NASA Technical Reports Server (NTRS)

Proctor, Fred H.; Ahmad, Nashat N.

2011-01-01

Parametric simulations with a Large Eddy Simulation (LES) model are used to explore the influence of crosswind shear on aircraft wake vortices. Previous studies based on field measurements, laboratory experiments, as well as LES, have shown that the vertical gradient of crosswind shear, i.e. the second vertical derivative of the environmental crosswind, can influence wake vortex transport. The presence of nonlinear vertical shear of the crosswind velocity can reduce the descent rate, causing a wake vortex pair to tilt and change in its lateral separation. The LES parametric studies confirm that the vertical gradient of crosswind shear does influence vortex trajectories. The parametric results also show that vortex decay from the effects of shear are complex since the crosswind shear, along with the vertical gradient of crosswind shear, can affect whether the lateral separation between wake vortices is increased or decreased. If the separation is decreased, the vortex linking time is decreased, and a more rapid decay of wake vortex circulation occurs. If the separation is increased, the time to link is increased, and at least one of the vortices of the vortex pair may have a longer life time than in the case without shear. In some cases, the wake vortices may never link.

Dog EEG for wake-promotion studies.

PubMed

Parmentier, Régis; Bricout, Denis; Brousseau, Emmanuel; Giboulot, Thierry

2006-10-01

Described in this unit is a protocol for investigating the wake-promoting activity of new chemical entities (NCEs) in dog. The experimental approach is based on scoring of sleep/wake stages in animals implanted with a telemetry device for recording EMG and cortical EEG signals. A major advantage of this procedure is that it is conducted in nontethered animals, limiting possible bias and complications encountered with conventional recording systems. In this procedure, polygraphic recording is conducted using four implanted beagles. Results of studies with modafinil, a wake-promoting agent, are described to demonstrate the utility of this test procedure.

Peer-Assisted Learning: Filling the Gaps in Basic Science Education for Preclinical Medical Students

ERIC Educational Resources Information Center

Sammaraiee, Yezen; Mistry, Ravi D.; Lim, Julian; Wittner, Liora; Deepak, Shantal; Lim, Gareth

2016-01-01

In contrast to peer-assisted learning (PAL) in clinical training, there is scant literature on the efficacy of PAL during basic medical sciences teaching for preclinical students. A group of senior medical students aimed to design and deliver clinically oriented small-group tutorials after every module in the preclinical curriculum at a United…

The Future of Basic Science in Academic Surgery: Identifying Barriers to Success for Surgeon-scientists.

PubMed

Keswani, Sundeep G; Moles, Chad M; Morowitz, Michael; Zeh, Herbert; Kuo, John S; Levine, Matthew H; Cheng, Lily S; Hackam, David J; Ahuja, Nita; Goldstein, Allan M

2017-06-01

The aim of this study was to examine the challenges confronting surgeons performing basic science research in today's academic surgery environment. Multiple studies have identified challenges confronting surgeon-scientists and impacting their ability to be successful. Although these threats have been known for decades, the downward trend in the number of successful surgeon-scientists continues. Clinical demands, funding challenges, and other factors play important roles, but a rigorous analysis of academic surgeons and their experiences regarding these issues has not previously been performed. An online survey was distributed to 2504 members of the Association for Academic Surgery and Society of University Surgeons to determine factors impacting success. Survey results were subjected to statistical analyses. We also reviewed publicly available data regarding funding from the National Institutes of Health (NIH). NIH data revealed a 27% decline in the proportion of NIH funding to surgical departments relative to total NIH funding from 2007 to 2014. A total of 1033 (41%) members responded to our survey, making this the largest survey of academic surgeons to date. Surgeons most often cited the following factors as major impediments to pursuing basic investigation: pressure to be clinically productive, excessive administrative responsibilities, difficulty obtaining extramural funding, and desire for work-life balance. Surprisingly, a majority (68%) did not believe surgeons can be successful basic scientists in today's environment, including departmental leadership. We have identified important barriers that confront academic surgeons pursuing basic research and a perception that success in basic science may no longer be achievable. These barriers need to be addressed to ensure the continued development of future surgeon-scientists.

On aerodynamic wake analysis and its relation to total aerodynamic drag in a wind tunnel environment

NASA Astrophysics Data System (ADS)

Guterres, Rui M.

The present work was developed with the goal of advancing the state of the art in the application of three-dimensional wake data analysis to the quantification of aerodynamic drag on a body in a low speed wind tunnel environment. Analysis of the existing tools, their strengths and limitations is presented. Improvements to the existing analysis approaches were made. Software tools were developed to integrate the analysis into a practical tool. A comprehensive derivation of the equations needed for drag computations based on three dimensional separated wake data is developed. A set of complete steps ranging from the basic mathematical concept to the applicable engineering equations is presented. An extensive experimental study was conducted. Three representative body types were studied in varying ground effect conditions. A detailed qualitative wake analysis using wake imaging and two and three dimensional flow visualization was performed. Several significant features of the flow were identified and their relation to the total aerodynamic drag established. A comprehensive wake study of this type is shown to be in itself a powerful tool for the analysis of the wake aerodynamics and its relation to body drag. Quantitative wake analysis techniques were developed. Significant post processing and data conditioning tools and precision analysis were developed. The quality of the data is shown to be in direct correlation with the accuracy of the computed aerodynamic drag. Steps are taken to identify the sources of uncertainty. These are quantified when possible and the accuracy of the computed results is seen to significantly improve. When post processing alone does not resolve issues related to precision and accuracy, solutions are proposed. The improved quantitative wake analysis is applied to the wake data obtained. Guidelines are established that will lead to more successful implementation of these tools in future research programs. Close attention is paid to

From Wake Steering to Flow Control

DOE PAGES

Fleming, Paul A.; Annoni, Jennifer; Churchfield, Matthew J.; ...

2017-11-22

In this article, we investigate the role of flow structures generated in wind farm control through yaw misalignment. A pair of counter-rotating vortices are shown to be important in deforming the shape of the wake and in explaining the asymmetry of wake steering in oppositely signed yaw angles. We motivate the development of new physics for control-oriented engineering models of wind farm control, which include the effects of these large-scale flow structures. Such a new model would improve the predictability of control-oriented models. Results presented in this paper indicate that wind farm control strategies, based on new control-oriented models withmore » new physics, that target total flow control over wake redirection may be different, and perhaps more effective, than current approaches. We propose that wind farm control and wake steering should be thought of as the generation of large-scale flow structures, which will aid in the improved performance of wind farms.« less

Analysis of Predicted Aircraft Wake Vortex Transport and Comparison with Experiment Volume I -- Wake Vortex Predictive System Study

DOT National Transportation Integrated Search

1974-04-01

A unifying wake vortex transport model is developed and applied to a wake vortex predictive system concept. The fundamentals of vortex motion underlying the predictive model are discussed including vortex decay, bursting and instability phenomena. A ...

Why Does Sleep Slow-Wave Activity Increase After Extended Wake? Assessing the Effects of Increased Cortical Firing During Wake and Sleep

PubMed Central

Rodriguez, Alexander V.; Funk, Chadd M.; Vyazovskiy, Vladyslav V.; Nir, Yuval; Tononi, Giulio

2016-01-01

During non-rapid eye movement (NREM) sleep, cortical neurons alternate between ON periods of firing and OFF periods of silence. This bi-stability, which is largely synchronous across neurons, is reflected in the EEG as slow waves. Slow-wave activity (SWA) increases with wake duration and declines homeostatically during sleep, but the underlying mechanisms remain unclear. One possibility is neuronal “fatigue”: high, sustained firing in wake would force neurons to recover with more frequent and longer OFF periods during sleep. Another possibility is net synaptic potentiation during wake: stronger coupling among neurons would lead to greater synchrony and therefore higher SWA. Here, we obtained a comparable increase in sustained firing (6 h) in cortex by: (1) keeping mice awake by exposure to novel objects to promote plasticity and (2) optogenetically activating a local population of cortical neurons at wake-like levels during sleep. Sleep after extended wake led to increased SWA, higher synchrony, and more time spent OFF, with a positive correlation between SWA, synchrony, and OFF periods. Moreover, time spent OFF was correlated with cortical firing during prior wake. After local optogenetic stimulation, SWA and cortical synchrony decreased locally, time spent OFF did not change, and local SWA was not correlated with either measure. Moreover, laser-induced cortical firing was not correlated with time spent OFF afterward. Overall, these results suggest that high sustained firing per se may not be the primary determinant of SWA increases observed after extended wake. SIGNIFICANCE STATEMENT A long-standing hypothesis is that neurons fire less during slow-wave sleep to recover from the “fatigue” accrued during wake, when overall synaptic activity is higher than in sleep. This idea, however, has rarely been tested and other factors, namely increased cortical synchrony, could explain why sleep slow-wave activity (SWA) is higher after extended wake. We forced

Why Does Sleep Slow-Wave Activity Increase After Extended Wake? Assessing the Effects of Increased Cortical Firing During Wake and Sleep.

PubMed

Rodriguez, Alexander V; Funk, Chadd M; Vyazovskiy, Vladyslav V; Nir, Yuval; Tononi, Giulio; Cirelli, Chiara

2016-12-07

During non-rapid eye movement (NREM) sleep, cortical neurons alternate between ON periods of firing and OFF periods of silence. This bi-stability, which is largely synchronous across neurons, is reflected in the EEG as slow waves. Slow-wave activity (SWA) increases with wake duration and declines homeostatically during sleep, but the underlying mechanisms remain unclear. One possibility is neuronal "fatigue": high, sustained firing in wake would force neurons to recover with more frequent and longer OFF periods during sleep. Another possibility is net synaptic potentiation during wake: stronger coupling among neurons would lead to greater synchrony and therefore higher SWA. Here, we obtained a comparable increase in sustained firing (6 h) in cortex by: (1) keeping mice awake by exposure to novel objects to promote plasticity and (2) optogenetically activating a local population of cortical neurons at wake-like levels during sleep. Sleep after extended wake led to increased SWA, higher synchrony, and more time spent OFF, with a positive correlation between SWA, synchrony, and OFF periods. Moreover, time spent OFF was correlated with cortical firing during prior wake. After local optogenetic stimulation, SWA and cortical synchrony decreased locally, time spent OFF did not change, and local SWA was not correlated with either measure. Moreover, laser-induced cortical firing was not correlated with time spent OFF afterward. Overall, these results suggest that high sustained firing per se may not be the primary determinant of SWA increases observed after extended wake. A long-standing hypothesis is that neurons fire less during slow-wave sleep to recover from the "fatigue" accrued during wake, when overall synaptic activity is higher than in sleep. This idea, however, has rarely been tested and other factors, namely increased cortical synchrony, could explain why sleep slow-wave activity (SWA) is higher after extended wake. We forced neurons in the mouse cortex to fire

Direct Simulation and Theoretical Study of Sub- and Supersonic Wakes

NASA Astrophysics Data System (ADS)

Hickey, Jean-Pierre

Wakes are constitutive components of engineering, aeronautical and geophysical flows. Despite their canonical nature, many fundamental questions surrounding wakes remain unanswered. The present work studies the nature of archetypal planar splitter-plate wakes in the sub- and supersonic regimes from a theoretical as well as a numerical perspective. A highly-parallelizable computational fluid dynamic solver was developed, from scratch, for the very-large scale direct numerical simulations of high-speed free shear flows. Wakes maintain a near indelible memory of their origins; thus, changes to the state of the flow on the generating body lead to multiple self-similar states in the far wake. To understand the source of the lack of universality, three distinct wake evolution scenarios are investigated in the incompressible limit: the Kelvin-Helmholtz transition, the bypass transition in an asymmetric wake and the initially turbulent wake. The multiplicity of self-similar states is the result of a plurality of far wake structural organizations, which maintains the memory of the flow. The structural organization is predicated on the presence or absence of near wake anti-symmetric perturbations (as a result of shedding, instability modes and/or trailing edge receptivity). The plurality of large-scale structural organization contrasts with the commonality observed in the mid-sized structures, which are dominated by inclined vortical rods, and not, as previously assumed, by horseshoe structures. The compressibility effects are a direct function of the maximal velocity defect in the wake and are therefore only important in the transitional region - the far wake having an essentially incompressible character. The compressibility simultaneously modifies the growth rate and wavelength of the primary instability mode with a concomitant effect on the emerging transitional structures. As a direct result, the spanwise rollers have an increasing ellipticity and cross-wake domain of

An elective course on the basic and clinical sciences aspects of vitamins and minerals.

PubMed

Islam, Mohammed A

2013-02-12

Objective. To develop and implement an elective course on vitamins and minerals and their usefulness as dietary supplements. Design. A 2-credit-hour elective course designed to provide students with the most up-to-date basic and clinical science information on vitamins and minerals was developed and implemented in the doctor of pharmacy (PharmD) curriculum. In addition to classroom lectures, an active-learning component was incorporated in the course in the form of group discussion. Assessment. Student learning was demonstrated by examination scores. Performance on pre- and post-course surveys administered in 2011 demonstrated a significant increase in students' knowledge of the basic and clinical science aspects of vitamins and minerals, with average scores increasing from 61% to 86%. At the end of the semester, students completed a standard course evaluation. Conclusion. An elective course on vitamin and mineral supplements was well received by pharmacy students and helped them to acquire knowledge and competence in patient counseling regarding safe, appropriate, effective, and economical use of these products.

An Elective Course on the Basic and Clinical Sciences Aspects of Vitamins and Minerals

PubMed Central

2013-01-01

Objective. To develop and implement an elective course on vitamins and minerals and their usefulness as dietary supplements. Design. A 2-credit-hour elective course designed to provide students with the most up-to-date basic and clinical science information on vitamins and minerals was developed and implemented in the doctor of pharmacy (PharmD) curriculum. In addition to classroom lectures, an active-learning component was incorporated in the course in the form of group discussion. Assessment. Student learning was demonstrated by examination scores. Performance on pre- and post-course surveys administered in 2011 demonstrated a significant increase in students’ knowledge of the basic and clinical science aspects of vitamins and minerals, with average scores increasing from 61% to 86%. At the end of the semester, students completed a standard course evaluation. Conclusion. An elective course on vitamin and mineral supplements was well received by pharmacy students and helped them to acquire knowledge and competence in patient counseling regarding safe, appropriate, effective, and economical use of these products. PMID:23463149

Volumetric LiDAR scanning of a wind turbine wake and comparison with a 3D analytical wake model

NASA Astrophysics Data System (ADS)

Carbajo Fuertes, Fernando; Porté-Agel, Fernando

2016-04-01

A correct estimation of the future power production is of capital importance whenever the feasibility of a future wind farm is being studied. This power estimation relies mostly on three aspects: (1) a reliable measurement of the wind resource in the area, (2) a well-established power curve of the future wind turbines and, (3) an accurate characterization of the wake effects; the latter being arguably the most challenging one due to the complexity of the phenomenon and the lack of extensive full-scale data sets that could be used to validate analytical or numerical models. The current project addresses the problem of obtaining a volumetric description of a full-scale wake of a 2MW wind turbine in terms of velocity deficit and turbulence intensity using three scanning wind LiDARs and two sonic anemometers. The characterization of the upstream flow conditions is done by one scanning LiDAR and two sonic anemometers, which have been used to calculate incoming vertical profiles of horizontal wind speed, wind direction and an approximation to turbulence intensity, as well as the thermal stability of the atmospheric boundary layer. The characterization of the wake is done by two scanning LiDARs working simultaneously and pointing downstream from the base of the wind turbine. The direct LiDAR measurements in terms of radial wind speed can be corrected using the upstream conditions in order to provide good estimations of the horizontal wind speed at any point downstream of the wind turbine. All this data combined allow for the volumetric reconstruction of the wake in terms of velocity deficit as well as turbulence intensity. Finally, the predictions of a 3D analytical model [1] are compared to the 3D LiDAR measurements of the wind turbine. The model is derived by applying the laws of conservation of mass and momentum and assuming a Gaussian distribution for the velocity deficit in the wake. This model has already been validated using high resolution wind-tunnel measurements

EEG power during waking and NREM sleep in primary insomnia.

PubMed

Wu, You Meme; Pietrone, Regina; Cashmere, J David; Begley, Amy; Miewald, Jean M; Germain, Anne; Buysse, Daniel J

2013-10-15

Pathophysiological models of insomnia invoke the concept of 24-hour hyperarousal, which could lead to symptoms and physiological findings during waking and sleep. We hypothesized that this arousal could be seen in the waking electroencephalogram (EEG) of individuals with primary insomnia (PI), and that waking EEG power would correlate with non-REM (NREM) EEG. Subjects included 50 PI and 32 good sleeper controls (GSC). Five minutes of eyes closed waking EEG were collected at subjects' usual bedtimes, followed by polysomnography (PSG) at habitual sleep times. An automated algorithm and visual editing were used to remove artifacts from waking and sleep EEGs, followed by power spectral analysis to estimate power from 0.5-32 Hz. We did not find significant differences in waking or NREM EEG spectral power of PI and GSC. Significant correlations between waking and NREM sleep power were observed across all frequency bands in the PI group and in most frequency bands in the GSC group. The absence of significant differences between groups in waking or NREM EEG power suggests that our sample was not characterized by a high degree of cortical arousal. The consistent correlations between waking and NREM EEG power suggest that, in samples with elevated NREM EEG beta activity, waking EEG power may show a similar pattern.

Inlet Guide Vane Wakes Including Rotor Effects

NASA Astrophysics Data System (ADS)

Johnston, R. T.; Fleeter, S.

2001-02-01

Fundamental experiments are described directed at the investigation of forcing functions generated by an inlet guide vane (IGV) row, including interactions with the downstream rotor, for application to turbomachine forced response design systems. The experiments are performed in a high-speed research fan facility comprised of an IGV row upstream of a rotor. IGV-rotor axial spacing is variable, with the IGV row able to be indexed circumferentially, thereby allowing measurements to be made across several IGV wakes. With an IGV relative Mach number of 0.29, measurements include the IGV wake pressure and velocity fields for three IGV-rotor axial spacings. The decay characteristics of the IGV wakes are compared to the Majjigi and Gliebe empirical correlations. After Fourier decomposition, a vortical-potential gust splitting analysis is implemented to determine the vortical and potential harmonic wake gust forcing functions both upstream and downstream of the rotor. Higher harmonics of the vortical gust component of the IGV wakes are found to decay at a uniform rate due to viscous diffusion.

Radar Reflectivity in Wingtip-Generated Wake Vortices

NASA Technical Reports Server (NTRS)

Marshall, Robert E.; Mudukutore, Ashok; Wissel, Vicki

1997-01-01

This report documents new predictive models of radar reflectivity, with meter-scale resolution, for aircraft wakes in clear air and fog. The models result from a radar design program to locate and quantify wake vortices from commercial aircraft in support of the NASA Aircraft Vortex Spacing System (AVOSS). The radar reflectivity model for clear air assumes: 1) turbulent eddies in the wake produce small discontinuities in radar refractive index; and 2) these turbulent eddies are in the 'inertial subrange' of turbulence. From these assumptions, the maximum radar frequency for detecting a particular aircraft wake, as well as the refractive index structure constant and radar volume reflectivity in the wake can be obtained from the NASA Terminal Area Simulation System (TASS) output. For fog conditions, an empirical relationship is used to calculate radar reflectivity factor from TASS output of bulk liquid water. Currently, two models exist: 1) Atlas-based on observations of liquid water and radar reflectivity factor in clouds; and 2) de Wolf- specifically tailored to a specific measured dataset (1992 Vandenberg Air Force Base).

Wake loss and energy spread factor of the LEReC Booster cavity caused by short range wake field

DOE Office of Scientific and Technical Information (OSTI.GOV)

Xiao, Binping; Blaskiewicz, Michael; Fedotov, Alexei

LEReC project uses a DC photoemission gun with multi-alkali (CsK 2Sb or NaK 2Sb) cathode [1]. To get 24 mm “flat-top” distribution, 32 Gaussian laser bunches with 0.6 mm rms length are stacked together with 0.75 mm distance [2]. In this case one cannot simply use a 1 cm rms length Gaussian/step/delta bunch for short range wake field simulation since a 0.6 mm bunch contains frequency much higher than the 1 cm bunch. A short range wake field simulation was done using CST Particle Studio™ with 0.6 mm rms Gaussian bunch at the speed of light, and this result wasmore » compared with the result for 1 cm rms Gaussian bunch in Figure 1, from where one notice that the wake potential for the 0.6 mm bunch is ~10 times higher than that of the 1 cm bunch. The wake potential of the 0.6 mm bunch, as well as the charge distribution, was then “shift and stack” every 0.75 mm, the normalized results are shown in Figure 2. The wake loss factor (WLF) is the integration of the product of wake potential and normalized bunch charge, and the energy spread factor (ESF) is the rms deviation from the average energy loss. It is calculated by summing the weighted squares of the differences and taking the square root of the sum. These two factors were then divided by β 2 for 1.6 MV beam energy. The wake loss factor is at 0.86 V/pC and energy spread factor is at 0.54 V/pC rms. With 100 pC electron bunch, the energy spread inter-bunch is 54 V rms.« less

International cooperation in basic space science, Western Asian countries and the world

NASA Astrophysics Data System (ADS)

de Morais Mendonca Teles, Antonio

The world will never better develop and attain a global peace state, if it does not exist a world-wide cooperation, union of interests among all countries on planet Earth, respecting and understanding each other culture differences. So, if the countries interested in space science want to create or better develop this field, they need to firstly construct peace states and social cooperation, while scientific and technological cooperation will develop -among them. Here in this paper, under the principles in the United Nations (UN)' Agenda 21 (UN UNCED, 1992), I propose four points that can lead to a practical and solid international cooperation in basic aerospace science and technology, based on ground studies, with sustainable space programs in countries with social necessities, and to the construction of an avenue of peace states in those areas and in the world, 1) The creation of LINKS among the "developing" countries, among the "developed" ones and between them -with scientists, engineers, educators and administrative personnel. This can catalyze a self-sustainable scientific and technological production in the "developing" countries. Financial matters could be done through the World Bank in coopera-tion with UNESCO. 2) The administration of this difficult enterprise of international coopera-tion. With the increasing complexity of relationships among the aerospace-interested countries, it will be necessary the creation of a center capable to serve as an INTERNATIONAL CO-ORDINATOR CENTER FOR AEROSPACE ACTIVITIES. 3) CULTURE: in Western Asian countries there is a cultural habit that when somebody gives something valuable to a person, this person should give something back. Thus, the Western Asian countries receiving infor-mation on basic aerospace science and technology from the "developed" ones, those countries would probably feel they should give something in return. Western Asian countries could trans-mit their costumes, thinking ways, habits, persons' worries

Solar-wind proton access deep into the near-Moon wake

NASA Astrophysics Data System (ADS)

Nishino, M. N.; Fujimoto, M.; Maezawa, K.; Saito, Y.; Yokota, S.; Asamura, K.; Tanaka, T.; Tsunakawa, H.; Matsushima, M.; Takahashi, F.; Terasawa, T.; Shibuya, H.; Shimizu, H.

2009-08-01

We study solar wind (SW) entry deep into the near-Moon wake using SELENE (KAGUYA) data. It has been known that SW protons flowing around the Moon access the central region of the distant lunar wake, while their intrusion deep into the near-Moon wake has never been expected. We show that SW protons sneak into the deepest lunar wake (anti-subsolar region at ˜100 km altitude), and that the entry yields strong asymmetry of the near-Moon wake environment. Particle trajectory calculations demonstrate that these SW protons are once scattered at the lunar dayside surface, picked-up by the SW motional electric field, and finally sneak into the deepest wake. Our results mean that the SW protons scattered at the lunar dayside surface and coming into the night side region are crucial for plasma environment in the wake, suggesting absorption of ambient SW electrons into the wake to maintain quasi-neutrality.

On the investigation of cascade and turbomachinery rotor wake characteristics

NASA Technical Reports Server (NTRS)

Raj, R.; Lakshminarayana, B.

1975-01-01

The objective of the investigation reported in this thesis is to study the characteristics of a turbomachinery rotor wake, both analytically and experimentally. The constitutive equations for the rotor wake are developed using generalized tensors and a non-inertial frame of reference. Analytical and experimental investigation is carried out in two phases; the first phase involved the study of a cascade wake in the absence of rotation and three dimensionality. In the second phase the wake of a rotor is studied. Simplified two- and three-dimensional models are developed for the prediction of the mean velocity profile of the cascade and the rotor wake, respectively, using the principle of self-similarity. The effect of various major parameters of the rotor and the flow geometry is studied on the development of a rotor wake. Laws governing the decay of the wake velocity defect in a cascade and rotor wake as a function of downstream distance from the trailing edge, pressure gradient and other parameters are derived.

Basic Science and Public Policy: Informed Regulation for Nicotine and Tobacco Products.

PubMed

Fowler, Christie D; Gipson, Cassandra D; Kleykamp, Bethea A; Rupprecht, Laura E; Harrell, Paul T; Rees, Vaughan W; Gould, Thomas J; Oliver, Jason; Bagdas, Deniz; Damaj, M Imad; Schmidt, Heath D; Duncan, Alexander; De Biasi, Mariella

2018-06-07

Scientific discoveries over the past few decades have provided significant insight into the abuse liability and negative health consequences associated with tobacco and nicotine-containing products. While many of these advances have led to the development of policies and laws that regulate access to and formulations of these products, further research is critical to guide future regulatory efforts, especially as novel nicotine-containing products are introduced and selectively marketed to vulnerable populations. In this narrative review, we provide an overview of the scientific findings that have impacted regulatory policy and discuss considerations for further translation of science into policy decisions. We propose that open, bidirectional communication between scientists and policy makers is essential to develop transformative preventive- and intervention-focused policies and programs to reduce appeal, abuse liability, and toxicity of the products. Through these types of interactions, collaborative efforts to inform and modify policy have the potential to significantly decrease the use of tobacco and alternative nicotine products and thus enhance health outcomes for individuals. This work addresses current topics in the nicotine and tobacco research field to emphasize the importance of basic science research and provide examples of how it can be utilized to inform public policy. In addition to relaying current thoughts on the topic from experts in the field, the article encourages continued efforts and communication between basic scientists and policy officials.

Basic science faculty in surgical departments: advantages, disadvantages and opportunities.

PubMed

Chinoy, Mala R; Moskowitz, Jay; Wilmore, Douglas W; Souba, Wiley W

2005-01-01

The number of Ph.D. faculty in clinical departments now exceeds the number of Ph.D. faculty in basic science departments. Given the escalating pressures on academic surgeons to produce in the clinical arena, the recruitment and retention of high-quality Ph.D.s will become critical to the success of an academic surgical department. This success will be as dependent on the surgical faculty understanding the importance of the partnership as the success of the Ph.D. investigator. Tighter alignment among the various clinical and research programs and between surgeons and basic scientists will facilitate the generation of new knowledge that can be translated into useful products and services (thus improving care). To capitalize on what Ph.D.s bring to the table, surgery departments may need to establish a more formal research infrastructure that encourages the ongoing exchange of ideas and resources. Physically removing barriers between the research groups, encouraging the open exchange of techniques and observations and sharing core laboratories is characteristic of successful research teams. These strategies can meaningfully contribute to developing successful training program grants, program projects and bringing greater research recognition to the department of surgery.

Helicopter rotor wake geometry and its influence in forward flight. Volume 2: Wake geometry charts

NASA Technical Reports Server (NTRS)

Egolf, T. A.; Landgrebe, A. J.

1983-01-01

Isometric and projection view plots, inflow ratio nomographs, undistorted axial displacement nomographs, undistorted longitudinal and lateral coordinates, generalized axial distortion nomographs, blade/vortex passage charts, blade/vortex intersection angle nomographs, and fore and aft wake boundary charts are discussed. Example condition, in flow ratio, undistorted axial location, longitudinal and lateral coordinates, axial coordinates distortions, blade/tip vortex intersections, angle of intersection, and fore and aft wake boundaries are also discussed.

Integration of basic science and clinical medicine: the innovative approach of the cadaver biopsy project at the Boston University School of Medicine.

PubMed

Eisenstein, Anna; Vaisman, Lev; Johnston-Cox, Hillary; Gallan, Alexander; Shaffer, Kitt; Vaughan, Deborah; O'Hara, Carl; Joseph, Lija

2014-01-01

Curricular integration has emerged as a consistent theme in medical education reform. Vertical integration of topics such as pathology offers the potential to bring basic science content into the clinical arena, but faculty/student acceptance and curricular design pose challenges for such integration. The authors describe the Cadaver Biopsy Project (CBP) at Boston University School of Medicine as a sustainable model of vertical integration. Faculty and select senior medical students obtained biopsies of cadavers during the first-year gross anatomy course (fall 2009) and used these to develop clinical cases for courses in histology (spring 2010), pathology (fall 2010-spring 2011), and radiology (fall 2011 or spring 2012), thereby linking students' first experiences in basic sciences with other basic science courses and later clinical courses. Project goals included engaging medical stu dents in applying basic science princi ples in all aspects of patient care as they acquire skills. The educational intervention used a patient (cadaver)-centered approach and small-group, collaborative, case-based learning. Through this project, the authors involved clinical and basic science faculty-plus senior medical students-in a collaborative project to design and implement an integrated curriculum through which students revisited, at several different points, the microscopic structure and pathophysiology of common diseases. Developing appropriate, measurable out comes for medical education initiatives, including the CBP, is challenging. Accumu lation of qualitative feedback from surveys will guide continuous improvement of the CBP. Documenting longer-term impact of the curricular innovation on test scores and other competency-based outcomes is an ultimate goal.

Professional fulfillment and parenting work-life balance in female physicians in Basic Sciences and medical research: a nationwide cross-sectional survey of all 80 medical schools in Japan.

PubMed

Yamazaki, Yuka; Uka, Takanori; Marui, Eiji

2017-09-15

In Japan, the field of Basic Sciences encompasses clinical, academic, and translational research, as well as the teaching of medical sciences, with both an MD and PhD typically required. In this study, it was hypothesized that the characteristics of a Basic Sciences career path could offer the professional advancement and personal fulfillment that many female medical doctors would find advantageous. Moreover, encouraging interest in Basic Sciences could help stem shortages that Japan is experiencing in medical fields, as noted in the three principal contributing factors: premature resignation of female clinicians, an imbalance of female physicians engaged in research, and a shortage of medical doctors in the Basic Sciences. This study examines the professional and personal fulfillment expressed by Japanese female medical doctors who hold positions in Basic Sciences. Topics include career advancement, interest in medical research, and greater flexibility for parenting. A cross-sectional questionnaire survey was distributed at all 80 medical schools in Japan, directed to 228 female medical doctors whose academic rank was assistant professor or higher in departments of Basic Sciences in 2012. Chi-square tests and the binary logistic regression model were used to investigate the impact of parenthood on career satisfaction, academic rank, salary, etc. The survey response rate of female physicians in Basic Sciences was 54.0%. Regardless of parental status, one in three respondents cited research interest as their rationale for entering Basic Sciences, well over twice other motivations. A majority had clinical experience, with clinical duties maintained part-time by about half of respondents and particularly parents. Only one third expressed afterthoughts about relinquishing full-time clinical practice, with physicians who were parents expressing stronger regrets. Parental status had little effect on academic rank and income within the Basic Sciences, CONCLUSION

On the wake of a Darrieus turbine

NASA Technical Reports Server (NTRS)

Base, T. E.; Phillips, P.; Robertson, G.; Nowak, E. S.

1981-01-01

The theory and experimental measurements on the aerodynamic decay of a wake from high performance vertical axis wind turbine are discussed. In the initial experimental study, the wake downstream of a model Darrieus rotor, 28 cm diameter and a height of 45.5 cm, was measured in a Boundary Layer Wind Tunnel. The wind turbine was run at the design tip speed ratio of 5.5. It was found that the wake decayed at a slower rate with distance downstream of the turbine, than a wake from a screen with similar troposkein shape and drag force characteristics as the Darrieus rotor. The initial wind tunnel results indicated that the vertical axis wind turbines should be spaced at least forty diameters apart to avoid mutual power depreciation greater than ten per cent.

Role of the locus coeruleus in the emergence of power law wake bouts in a model of the brainstem sleep-wake system through early infancy.

PubMed

Patel, Mainak; Rangan, Aaditya

2017-08-07

Infant rats randomly cycle between the sleeping and waking states, which are tightly correlated with the activity of mutually inhibitory brainstem sleep and wake populations. Bouts of sleep and wakefulness are random; from P2-P10, sleep and wake bout lengths are exponentially distributed with increasing means, while during P10-P21, the sleep bout distribution remains exponential while the distribution of wake bouts gradually transforms to power law. The locus coeruleus (LC), via an undeciphered interaction with sleep and wake populations, has been shown experimentally to be responsible for the exponential to power law transition. Concurrently during P10-P21, the LC undergoes striking physiological changes - the LC exhibits strong global 0.3 Hz oscillations up to P10, but the oscillation frequency gradually rises and synchrony diminishes from P10-P21, with oscillations and synchrony vanishing at P21 and beyond. In this work, we construct a biologically plausible Wilson Cowan-style model consisting of the LC along with sleep and wake populations. We show that external noise and strong reciprocal inhibition can lead to switching between sleep and wake populations and exponentially distributed sleep and wake bout durations as during P2-P10, with the parameters of inhibition between the sleep and wake populations controlling mean bout lengths. Furthermore, we show that the changing physiology of the LC from P10-P21, coupled with reciprocal excitation between the LC and wake population, can explain the shift from exponential to power law of the wake bout distribution. To our knowledge, this is the first study that proposes a plausible biological mechanism, which incorporates the known changing physiology of the LC, for tying the developing sleep-wake circuit and its interaction with the LC to the transformation of sleep and wake bout dynamics from P2-P21. Copyright © 2017 Elsevier Ltd. All rights reserved.

Tomographic particle image velocimetry of desert locust wakes: instantaneous volumes combine to reveal hidden vortex elements and rapid wake deformation

PubMed Central

Bomphrey, Richard J.; Henningsson, Per; Michaelis, Dirk; Hollis, David

2012-01-01

Aerodynamic structures generated by animals in flight are unstable and complex. Recent progress in quantitative flow visualization has advanced our understanding of animal aerodynamics, but measurements have hitherto been limited to flow velocities at a plane through the wake. We applied an emergent, high-speed, volumetric fluid imaging technique (tomographic particle image velocimetry) to examine segments of the wake of desert locusts, capturing fully three-dimensional instantaneous flow fields. We used those flow fields to characterize the aerodynamic footprint in unprecedented detail and revealed previously unseen wake elements that would have gone undetected by two-dimensional or stereo-imaging technology. Vortex iso-surface topographies show the spatio-temporal signature of aerodynamic force generation manifest in the wake of locusts, and expose the extent to which animal wakes can deform, potentially leading to unreliable calculations of lift and thrust when using conventional diagnostic methods. We discuss implications for experimental design and analysis as volumetric flow imaging becomes more widespread. PMID:22977102

Teaching population health as a basic science at Harvard Medical School.

PubMed

Finkelstein, Jonathan A; McMahon, Graham T; Peters, Antoinette; Cadigan, Rebecca; Biddinger, Paul; Simon, Steven R

2008-04-01

In 2006-2007, Harvard Medical School implemented a new, required course for first-year medical and dental students entitled Clinical Epidemiology and Population Health. Conceived of as a "basic science" course, its primary goal is to allow students to develop an understanding of caring for individuals and promoting the health of populations as a continuum of strategies, all requiring the engagement of physicians. In the course's first iteration, topical content accessible to first-year students was selected to exemplify physicians' roles in addressing current threats to population health. Methodological areas included domains of clinical epidemiology, decision sciences, population-level prevention and health promotion, physicians' roles in the public health system, and population-level surveillance and intervention strategies. Large-group settings were selectively used to frame the relevance of each topic, and conceptual learning of statistical and epidemiologic methods occurred in conference groups of 24 students. Finally, tutorials of eight students and one or two faculty were used for critical reading of published studies, review of problem sets, and group discussion of population health issues. To help students appreciate the structure and function of the public health system and physicians' role in public health emergencies, the course included a role-playing exercise simulating response to an influenza pandemic. The first iteration of the course was well received, and assessment of students suggested mastery of basic skills. Preclinical courses represent a progressive step in developing a workforce of physicians who embrace their responsibility to improve the health of the population as a whole, as well as the health of the patient in front of them.

Wake vortex properties and thrust production of a harmonically-pitching flexible airfoil at low Reynolds number

NASA Astrophysics Data System (ADS)

Olson, David; Naguib, Ahmed; Koochesfahani, Manoochehr

2017-11-01

Many of the natural flyers have deformable wing structures and exhibit complex kinematics in order to produce lift and thrust. Replicating all of these conditions in the laboratory (or in simulations) is extremely difficult, and drawing explicit connections to basic unsteady aerodynamics models and theories is even more complicated. Therefore, simplified wing structure and kinematics are typically used to facilitate drawing out these connections. In this work, measurements are conducted using a rigid and a chordwise-flexible NACA 0009 airfoils when harmonically pitched about the quarter chord point. Molecular tagging velocimetry is used to characterize the wake and estimate the thrust based on the momentum integral equation as function of the reduced frequency and the pitching amplitude. The results obtained using the two different airfoils are compared in order to examine the influence of structural flexibility. Consistent with the literature, chordwise flexibility is found to enhance thrust production and the circulation of the vortices shed into the wake, for a certain range of frequencies and amplitudes. Additional characterizations are undertaken of the wake vortex structure and its scaling. This work was supported by AFOSR Award Number FA9550-10-1-0342.

Evolution of plasma wakes in density up- and down-ramps

NASA Astrophysics Data System (ADS)

Zhang, C. J.; Joshi, C.; Xu, X. L.; Mori, W. B.; Li, F.; Wan, Y.; Hua, J. F.; Pai, C. H.; Wang, J.; Lu, W.

2018-02-01

The time evolution of plasma wakes in density up- and down-ramps is examined through theory and particle-in-cell simulations. Motivated by observation of the reversal of a linear plasma wake in a plasma density upramp in a recent experiment (Zhang et al 2017 Phys. Rev. Lett. 119 064801) we have examined the behaviour of wakes in plasma ramps that always accompany any plasma source used for plasma-based acceleration. In the up-ramp case it is found that, after the passage of the drive pulse, the wavnumber/wavelength of the wake starts to decrease/increase with time until it eventually tends to zero/infinity, then the wake reverses its propagation direction and the wavenunber/wavelength of the wake begins to increase/shrink. The evolutions of the wavenumber and the phase velocity of the wake as functions of time are shown to be significantly different in the up-ramp and the down-ramp cases. In the latter case the wavenumber of the wake at a particular position in the ramp increases until the wake is eventually damped. It is also shown that the waveform of the wake at a particular time after being excited can be precisely controlled by tuning the initial plasma density profile, which may enable a new type of plasma-based ultrafast optics.

Alternative Methods by Which Basic Science Pharmacy Faculty Can Relate to Clinical Practice, Executive Summary and Final Report, October 1, 1978 - March 15, 1980.

ERIC Educational Resources Information Center

Kabat, Hugh F.; And Others

The areas of basic science pharmacy instruction and clinical pharmacy practice and their interrelationships were identified in order to help develop didactic and clinical experience alternatives. A 10-member advisory committee ranked basic pharmaceutical science topical areas in terms of their applicability to clinical practice utilizing a Delphi…

Proceedings of the NASA First Wake Vortex Dynamic Spacing Workshop

NASA Technical Reports Server (NTRS)

Creduer, Leonard (Editor); Perry, R. Brad (Editor)

1997-01-01

A Government and Industry workshop on wake vortex dynamic spacing systems was conducted on May 13-15, 1997, at the NASA Langley Research Center. The purpose of the workshop was to disclose the status of ongoing NASA wake vortex R&D to the international community and to seek feedback on the direction of future work to assure an optimized research approach. Workshop sessions examined wake vortex characterization and physics, wake sensor technologies, aircraft/wake encounters, terminal area weather characterization and prediction, and wake vortex systems integration and implementation. A final workshop session surveyed the Government and Industry perspectives on the NASA research underway and related international wake vortex activities. This document contains the proceedings of the workshop including the presenters' slides, the discussion following each presentation, the wrap-up panel discussion, and the attendees' evaluation feedback.

Dissipation of turbulence in the wake of a wind turbine

NASA Astrophysics Data System (ADS)

Lundquist, J. K.; Bariteau, L.

2013-12-01

The wake of a wind turbine is characterized by increased turbulence and decreased wind speed. Turbines are generally deployed in large groups in wind farms, and so the behavior of an individual wake as it merges with other wakes and propagates downwind is of great importance in assessing wind farm power production as well as impacts of wind energy deployment on local and regional environments. The rate of turbulence dissipation in the wake quantifies the wake behavior as it propagates. In situ field measurements of turbulence dissipation rate in the wake of wind turbines have not been previously collected although correct modeling of dissipation rate is required for accurate simulations of wake evolution. In Fall 2012, we collected in situ measurements of winds and turbulence dissipation from the wake region of a multi-MW turbine, using the University of Colorado at Boulder's Tethered Lifting System (TLS). The TLS is a unique state-of-the-art tethersonde, proven in numerous boundary-layer field experiments to be able to measure turbulence kinetic energy dissipation rates. Ambient flow measurements were provided from sonic anemometers on a meteorological tower located upwind of the turbine, from a profiling lidar upwind, and from a scanning lidar measuring both inflow to and wake from the turbine. Measurements collected within the wake indicate that dissipation rates are higher in the turbine wake than in the ambient flow. Profiles of dissipation and turbulence throughout the rotor disk suggest that dissipation peaks near the hub height of the turbine. Suggestions for incorporating this information into wind turbine modeling approaches will be provided.

Cavitation and Wake Structure of Unsteady Tip Vortex Flows

DTIC Science & Technology

1992-12-10

wake structure generated by three-dimensional lifting surfaces. No longer can the wake be modeled as a simple horseshoe vortex structure with the tip...first initiates. -13- Z Strtn vortex "~Bound vortex "’ ; b Wake 2 Figure 1.5 Far-Field Horseshoe Model of a Finite Wing This figure shows a finite wing...Figure 1.11 Simplified Illustration of Wake Structure Behind an Oscillating Wing This schematic shows a simplified model of the trailing vortex

Stability Impact on Wake Development in Moderately Complex Terrain

NASA Astrophysics Data System (ADS)

Infield, D.; Zorzi, G.

2017-05-01

This paper uses a year of SCADA data from Whitelee Wind Farm near Glasgow to investigate wind turbine wake development in moderately complex terrain. Atmospheric stability measurements in terms of Richardson number from a met mast at an adjoining site have been obtained and used to assess the impact of stability on wake development. Considerable filtering of these data has been undertaken to ensure that all turbines are working normally and are well aligned with the wind direction. A group of six wind turbines, more or less in a line, have been selected for analysis, and winds within a 2 degree direction sector about this line are used to ensure, as far as possible, that all the turbines investigated are fully immersed in the wake/s of the upstream turbine/s. Results show how the terrain effects combine with the wake effects, with both being of comparable importance for the site in question. Comparison has been made with results from two commercial CFD codes for neutral stability, and reasonable agreement is demonstrated. Richardson number has been plotted against wind shear and turbulence intensity at a met mast on the wind farm that for the selected wind direction is not in the wake of any turbines. Good correlations are found indicating that the Richardson numbers obtained are reliable. The filtered data used for wake analysis were split according to Richardson number into two groups representing slightly stable to neutral, and unstable conditions. Very little difference in wake development is apparent. A greater difference can be observed when the data are separated simply by turbulence intensity, suggesting that, although turbulence intensity is correlated with stability, of the two it is the parameter that most directly impacts on wake development through mixing of ambient and wake flows.

Acoustic imaging of aircraft wake vortex dynamics

DOT National Transportation Integrated Search

2005-06-01

The experience in utilizing a phased microphone array to passively image aircraft wake : vortices is highlighted. It is demonstrated that the array can provide visualization of wake : dynamics similar to smoke release or natural condensation of vorti...

The HelCat basic plasma science device

NASA Astrophysics Data System (ADS)

Gilmore, M.; Lynn, A. G.; Desjardins, T. R.; Zhang, Y.; Watts, C.; Hsu, S. C.; Betts, S.; Kelly, R.; Schamiloglu, E.

2015-01-01

The Helicon-Cathode(HelCat) device is a medium-size linear experiment suitable for a wide range of basic plasma science experiments in areas such as electrostatic turbulence and transport, magnetic relaxation, and high power microwave (HPM)-plasma interactions. The HelCat device is based on dual plasma sources located at opposite ends of the 4 m long vacuum chamber - an RF helicon source at one end and a thermionic cathode at the other. Thirteen coils provide an axial magnetic field B >= 0.220 T that can be configured individually to give various magnetic configurations (e.g. solenoid, mirror, cusp). Additional plasma sources, such as a compact coaxial plasma gun, are also utilized in some experiments, and can be located either along the chamber for perpendicular (to the background magnetic field) plasma injection, or at one of the ends for parallel injection. Using the multiple plasma sources, a wide range of plasma parameters can be obtained. Here, the HelCat device is described in detail and some examples of results from previous and ongoing experiments are given. Additionally, examples of planned experiments and device modifications are also discussed.

Circadian Rhythm Sleep-Wake Disorders in Older Adults.

PubMed

Kim, Jee Hyun; Duffy, Jeanne F

2018-03-01

The timing, duration, and consolidation of sleep result from the interaction of the circadian timing system with a sleep-wake homeostatic process. When aligned and functioning optimally, this allows wakefulness throughout the day and a long consolidated sleep episode at night. Mismatch between the desired timing of sleep and the ability to fall and remain asleep is a hallmark of the circadian rhythm sleep-wake disorders. This article discusses changes in circadian regulation of sleep with aging; how age influences the prevalence, diagnosis, and treatment of circadian rhythm sleep-wake disorders; and how neurologic diseases in older patients affect circadian rhythms and sleep. Copyright © 2017 Elsevier Inc. All rights reserved.

Aircraft Wake Vortices : An Assessment of the Current Situation

DOT National Transportation Integrated Search

1991-01-01

The state of knowledge about aircraft wake vortices in the summer of 1990 is summarized. With the advent of a new FAA wake vortex program, the current situation was assessed by answering five questions: (1) What do we know about wake vortices, (2) wh...

Direct Numerical Simulation of a Weakly Stratified Turbulent Wake

NASA Technical Reports Server (NTRS)

Redford, J. A.; Lund, T. S.; Coleman, Gary N.

2014-01-01

Direct numerical simulation (DNS) is used to investigate a time-dependent turbulent wake evolving in a stably stratified background. A large initial Froude number is chosen to allow the wake to become fully turbulent and axisymmetric before stratification affects the spreading rate of the mean defect. The uncertainty introduced by the finite sample size associated with gathering statistics from a simulation of a time-dependent flow is reduced, compared to earlier simulations of this flow. The DNS reveals the buoyancy-induced changes to the turbulence structure, as well as to the mean-defect history and the terms in the mean-momentum and turbulence-kinetic-energy budgets, that characterize the various states of this flow - namely the three-dimensional (essentially unstratified), non-equilibrium (or 'wake-collapse') and quasi-two-dimensional (or 'two-component') regimes observed elsewhere for wakes embedded in both weakly and strongly stratified backgrounds. The wake-collapse regime is not accompanied by transfer (or 'reconversion') of the potential energy of the turbulence to the kinetic energy of the turbulence, implying that this is not an essential feature of stratified-wake dynamics. The dependence upon Reynolds number of the duration of the wake-collapse period is demonstrated, and the effect of the details of the initial/near-field conditions of the wake on its subsequent development is examined.

Long-term oscillations in the sleep/wake cycle of infants

NASA Astrophysics Data System (ADS)

Diambra, L.; Malta, C. P.; Capurro, A.

2009-11-01

The development of circadian sleep-wakefulness rhythm was investigated by a longitudinal study of six normal infants. We propose an entropy based measure for the sleep/wake cycle fragmentation. Our results confirm that the sleep/wake cycle fragmentation and the sleep/wake ratio decrease, while the circadian power increases during the maturation process of infants. In addition to these expected linear trends in the variables devised to quantify sleep consolidation, circadian power and sleep/wake ratio, we found that they present infradian rhythms in the monthly range.

Three-dimensional structure of wind turbine wakes as measured by scanning lidar

NASA Astrophysics Data System (ADS)

Bodini, Nicola; Zardi, Dino; Lundquist, Julie K.

2017-08-01

The lower wind speeds and increased turbulence that are characteristic of turbine wakes have considerable consequences on large wind farms: turbines located downwind generate less power and experience increased turbulent loads. The structures of wakes and their downwind impacts are sensitive to wind speed and atmospheric variability. Wake characterization can provide important insights for turbine layout optimization in view of decreasing the cost of wind energy. The CWEX-13 field campaign, which took place between June and September 2013 in a wind farm in Iowa, was designed to explore the interaction of multiple wakes in a range of atmospheric stability conditions. Based on lidar wind measurements, we extend, present, and apply a quantitative algorithm to assess wake parameters such as the velocity deficits, the size of the wake boundaries, and the location of the wake centerlines. We focus on wakes from a row of four turbines at the leading edge of the wind farm to explore variations between wakes from the edge of the row (outer wakes) and those from turbines in the center of the row (inner wakes). Using multiple horizontal scans at different elevations, a three-dimensional structure of wakes from the row of turbines can be created. Wakes erode very quickly during unstable conditions and can in fact be detected primarily in stable conditions in the conditions measured here. During stable conditions, important differences emerge between the wakes of inner turbines and the wakes of outer turbines. Further, the strong wind veer associated with stable conditions results in a stretching of the wake structures, and this stretching manifests differently for inner and outer wakes. These insights can be incorporated into low-order wake models for wind farm layout optimization or for wind power forecasting.

Three-dimensional structure of wind turbine wakes as measured by scanning lidar

DOE PAGES

Bodini, Nicola; Zardi, Dino; Lundquist, Julie K.

2017-08-14

The lower wind speeds and increased turbulence that are characteristic of turbine wakes have considerable consequences on large wind farms: turbines located downwind generate less power and experience increased turbulent loads. The structures of wakes and their downwind impacts are sensitive to wind speed and atmospheric variability. Wake characterization can provide important insights for turbine layout optimization in view of decreasing the cost of wind energy. The CWEX-13 field campaign, which took place between June and September 2013 in a wind farm in Iowa, was designed to explore the interaction of multiple wakes in a range of atmospheric stability conditions.more » Based on lidar wind measurements, we extend, present, and apply a quantitative algorithm to assess wake parameters such as the velocity deficits, the size of the wake boundaries, and the location of the wake centerlines. We focus on wakes from a row of four turbines at the leading edge of the wind farm to explore variations between wakes from the edge of the row (outer wakes) and those from turbines in the center of the row (inner wakes). Using multiple horizontal scans at different elevations, a three-dimensional structure of wakes from the row of turbines can be created. Wakes erode very quickly during unstable conditions and can in fact be detected primarily in stable conditions in the conditions measured here. During stable conditions, important differences emerge between the wakes of inner turbines and the wakes of outer turbines. Further, the strong wind veer associated with stable conditions results in a stretching of the wake structures, and this stretching manifests differently for inner and outer wakes. As a result, these insights can be incorporated into low-order wake models for wind farm layout optimization or for wind power forecasting.« less

Three-dimensional structure of wind turbine wakes as measured by scanning lidar

DOE Office of Scientific and Technical Information (OSTI.GOV)

Bodini, Nicola; Zardi, Dino; Lundquist, Julie K.

The lower wind speeds and increased turbulence that are characteristic of turbine wakes have considerable consequences on large wind farms: turbines located downwind generate less power and experience increased turbulent loads. The structures of wakes and their downwind impacts are sensitive to wind speed and atmospheric variability. Wake characterization can provide important insights for turbine layout optimization in view of decreasing the cost of wind energy. The CWEX-13 field campaign, which took place between June and September 2013 in a wind farm in Iowa, was designed to explore the interaction of multiple wakes in a range of atmospheric stability conditions.more » Based on lidar wind measurements, we extend, present, and apply a quantitative algorithm to assess wake parameters such as the velocity deficits, the size of the wake boundaries, and the location of the wake centerlines. We focus on wakes from a row of four turbines at the leading edge of the wind farm to explore variations between wakes from the edge of the row (outer wakes) and those from turbines in the center of the row (inner wakes). Using multiple horizontal scans at different elevations, a three-dimensional structure of wakes from the row of turbines can be created. Wakes erode very quickly during unstable conditions and can in fact be detected primarily in stable conditions in the conditions measured here. During stable conditions, important differences emerge between the wakes of inner turbines and the wakes of outer turbines. Further, the strong wind veer associated with stable conditions results in a stretching of the wake structures, and this stretching manifests differently for inner and outer wakes. As a result, these insights can be incorporated into low-order wake models for wind farm layout optimization or for wind power forecasting.« less

Reviews/Essays: School Start Times and the Sleep-Wake Cycle of Adolescents--A Review and Critical Evaluation of Available Evidence

ERIC Educational Resources Information Center

Kirby, Matthew; Maggi, Stefania; D'Angiulli, Amedeo

2011-01-01

The authors have integrated the major findings on the sleep-wake cycle and its performance correlates in adolescents. Basic research shows that lack of synchronicity between early school start times and the circadian rhythm of adolescents (and the sleep debt accumulated as a result) involves several cognitive correlates that may harm the academic…

Brief wakeful resting can eliminate directed forgetting.

PubMed

Schlichting, Andreas; Bäuml, Karl-Heinz T

2017-02-01

When cued to intentionally forget previously encoded memories, participants typically show reduced recall of the memories on a later recall test. We examined how such directed forgetting is affected by a brief period of wakeful resting between encoding and test. Encoding was followed by a "passive" wakeful resting period in which subjects heard emotionally neutral music or perceived neutral pictures, or it was followed by an "active" distraction period in which subjects were engaged in counting or calculation tasks. Whereas typical directed forgetting was present after active distraction, the forgetting was absent after wakeful resting. The findings indicate that the degree to which people can intentionally forget memories is influenced by the cognitive activity that people engage in shortly after learning takes place. The results provide first evidence on the interplay between wakeful resting and intentional forgetting.

Sleep-wake disturbances after traumatic brain injury.

PubMed

Ouellet, Marie-Christine; Beaulieu-Bonneau, Simon; Morin, Charles M

2015-07-01

Sleep-wake disturbances are extremely common after a traumatic brain injury (TBI). The most common disturbances are insomnia (difficulties falling or staying asleep), increased sleep need, and excessive daytime sleepiness that can be due to the TBI or other sleep disorders associated with TBI, such as sleep-related breathing disorder or post-traumatic hypersomnia. Sleep-wake disturbances can have a major effect on functional outcomes and on the recovery process after TBI. These negative effects can exacerbate other common sequelae of TBI-such as fatigue, pain, cognitive impairments, and psychological disorders (eg, depression and anxiety). Sleep-wake disturbances associated with TBI warrant treatment. Although evidence specific to patients with TBI is still scarce, cognitive-behavioural therapy and medication could prove helpful to alleviate sleep-wake disturbances in patients with a TBI. Copyright © 2015 Elsevier Ltd. All rights reserved.

Circadian Sleep-Wake Rhythm of Older Adults with Intellectual Disabilities

ERIC Educational Resources Information Center

Maaskant, Marijke; van de Wouw, Ellen; van Wijck, Ruud; Evenhuis, Heleen M.; Echteld, Michael A.

2013-01-01

The circadian sleep-wake rhythm changes with aging, resulting in a more fragmented sleep-wake pattern. In individuals with intellectual disabilities (ID), brain structures regulating the sleep-wake rhythm might be affected. The aims of this study were to compare the sleep-wake rhythm of older adults with ID to that of older adults in the general…

Restructuring a basic science course for core competencies: an example from anatomy teaching.

PubMed

Gregory, Jeremy K; Lachman, Nirusha; Camp, Christopher L; Chen, Laura P; Pawlina, Wojciech

2009-09-01

Medical schools revise their curricula in order to develop physicians best skilled to serve the public's needs. To ensure a smooth transition to residency programs, undergraduate medical education is often driven by the six core competencies endorsed by the Accreditation Council for Graduate Medical Education (ACGME): patient care, medical knowledge, practice-based learning, interpersonal skills, professionalism, and systems-based practice. Recent curricular redesign at Mayo Medical School provided an opportunity to restructure anatomy education and integrate radiology with first-year gross and developmental anatomy. The resulting 6-week (120-contact-hour) human structure block provides students with opportunities to learn gross anatomy through dissection, radiologic imaging, and embryologic correlation. We report more than 20 educational interventions from the human structure block that may serve as a model for incorporating the ACGME core competencies into basic science and early medical education. The block emphasizes clinically-oriented anatomy, invites self- and peer-evaluation, provides daily formative feedback through an audience response system, and employs team-based learning. The course includes didactic briefing sessions and roles for students as teachers, leaders, and collaborators. Third-year medical students serve as teaching assistants. With its clinical focus and competency-based design, the human structure block connects basic science with best-practice clinical medicine.

Translating Basic Behavioral and Social Science Research to Clinical Application: The EVOLVE Mixed Methods Approach

ERIC Educational Resources Information Center

Peterson, Janey C.; Czajkowski, Susan; Charlson, Mary E.; Link, Alissa R.; Wells, Martin T.; Isen, Alice M.; Mancuso, Carol A.; Allegrante, John P.; Boutin-Foster, Carla; Ogedegbe, Gbenga; Jobe, Jared B.

2013-01-01

Objective: To describe a mixed-methods approach to develop and test a basic behavioral science-informed intervention to motivate behavior change in 3 high-risk clinical populations. Our theoretically derived intervention comprised a combination of positive affect and self-affirmation (PA/SA), which we applied to 3 clinical chronic disease…

Projects for the implementation of science technology society approach in basic concept of natural science course as application of optical and electrical instruments’ material

NASA Astrophysics Data System (ADS)

Satria, E.

2018-03-01

Preservice teachers in primary education should be well equipped to meet the challenges of teaching primary science effectively in 21century. The purpose of this research was to describe the projects for the implementation of Science-Technology-Society (STS) approach in Basic Concept of Natural Science course as application of optical and electrical instruments’ material by the preservice teachers in Elementary Schools Teacher Education Program. One of the reasons is the lack of preservice teachers’ ability in making projects for application of STS approach and optical and electrical instruments’ material in Basic Concept of Natural Science course. This research applied descriptive method. The instrument of the research was the researcher himself. The data were gathered through observation and documentation. Based on the results of the research, it was figured out that preservice teachers, in groups, were creatively and successful to make the projects of optical and electrical instruments assigned such as projector and doorbell. It was suggested that the construction of the instruments should be better (fixed and strong structure) and more attractive for both instruments, and used strong light source, high quality images, and it could use speaker box for projector, power battery, and heat sink for electrical instruments.

The Case of the Neutron Star With a Wayward Wake

NASA Astrophysics Data System (ADS)

2006-06-01

A long observation with NASA's Chandra X-ray Observatory has revealed important new details of a neutron star that is spewing out a wake of high-energy particles as it races through space. The deduced location of the neutron star on the edge of a supernova remnant, and the peculiar orientation of the neutron star wake, pose mysteries that remain unresolved. "Like a kite flying in the wind, the behavior of this neutron star and its wake tell us what sort of gas it must be plowing through," said Bryan Gaensler of the Harvard-Smithsonian Center for Astrophysics (CfA) in Cambridge, Mass., and lead author of a paper accepted to The Astrophysical Journal. "Yet we're still not sure how the neutron star got to its present location." Animation: Sequence of images of J0617 in IC 443 Animation: Sequence of images of J0617 in IC 443 The neutron star, known as CXOU J061705.3+222127, or J0617 for short, appears to lie near the outer edge of an expanding bubble of hot gas associated with the supernova remnant IC 443. Presumably, J0617 was created at the time of the supernova -- approximately 30,000 years ago -- and propelled away from the site of the explosion at about 500,000 miles per hour. However, the neutron star's wake is oriented almost perpendicularly to the direction expected if the neutron star were moving away from the center of the supernova remnant. This apparent misalignment had previously raised doubts about the association of the speeding neutron star with the supernova remnant. Gaensler and his colleagues provide strong evidence that J0617 was indeed born in the same explosion that created the supernova remnant. First, the shape of the neutron star's wake indicates it is moving a little faster than the speed of sound in Composite Images of SNR IC 443 Composite Images of SNR IC 443 the remnant's multimillion-degree gas. The velocity that one can then calculate from this conclusion closely matches the predicted pace of the neutron star. In contrast, if the neutron

International Survey on the Management of Wake-Up Stroke.

PubMed

de Castro-Afonso, Luís Henrique; Nakiri, Guilherme Seizem; Pontes-Neto, Octávio Marques; dos Santos, Antônio Carlos; Abud, Daniel Giansante

2016-01-01

Patients who wake up having experienced a stroke while asleep represent around 20% of acute stroke admissions. According to international guidelines for the management of acute stroke, patients presenting with wake-up stroke are not currently eligible to receive revascularization treatments. In this study, we aimed to assess the opinions of stroke experts about the management of patients with wake-up stroke by using an international multicenter electronic survey. This study consisted of 8 questions on wake-up stroke treatment. Two hundred invitations to participate in the survey were sent by e-mail. Fifty-nine participants started the survey, 4 dropped out before completing it, and 55 completed the full questionnaire. We had 55 participants from 22 countries. In this study, most stroke experts recommended a recanalization treatment for wake-up stroke. However, there was considerable disagreement among experts regarding the best brain imaging method and the best recanalization treatment. The results of ongoing randomized trials on wake-up stroke are urgently needed.

Vortex Wakes of Subsonic Transport Aircraft

NASA Technical Reports Server (NTRS)

Rossow, Vernon J.; Nixon, David (Technical Monitor)

1999-01-01

A historical overview will be presented of the research conducted on the structure and modification of the vortices generated by the lifting surfaces of subsonic transport aircraft. The seminar will describe the three areas of vortex research; namely, the magnitude of the hazard posed, efforts to reduce the hazard to an acceptable level, and efforts to develop a systematic means for avoiding vortex wakes. It is first pointed out that the characteristics of lift-generated vortices are related to the aerodynamic shapes that produce them and that various arrangements of surfaces can be used to produce different vortex structures. The largest portion of the research conducted to date has been directed at finding ways to reduce the hazard potential of lift-generated vortices shed by subsonic transport aircraft in the vicinity of airports during landing and takeoff operations. It is stressed that lift-generated vortex wakes are so complex that progress towards a solution requires application of a combined theoretical and experimental research program because either alone often leads to incorrect conclusions. It is concluded that a satisfactory aerodynamic solution to the wake-vortex problem at airports has not yet been found but a reduction in the impact of the wake-vortex hazard on airport capacity may become available in the foreseeable future through wake-vortex avoidance concepts currently under study. The material to be presented in this overview is drawn from articles published in aerospace journals that are available publicly.

Forecasting behavior in smart homes based on sleep and wake patterns.

PubMed

Williams, Jennifer A; Cook, Diane J

2017-01-01

The goal of this research is to use smart home technology to assist people who are recovering from injuries or coping with disabilities to live independently. We introduce an algorithm to model and forecast wake and sleep behaviors that are exhibited by the participant. Furthermore, we propose that sleep behavior is impacted by and can be modeled from wake behavior, and vice versa. This paper describes the Behavior Forecasting (BF) algorithm. BF consists of 1) defining numeric values that reflect sleep and wake behavior, 2) forecasting wake and sleep values from past behavior, 3) analyzing the effect of wake behavior on sleep and vice versa, and 4) improving prediction performance by using both wake and sleep scores. The BF method was evaluated with data collected from 20 smart homes. We found that regardless of the forecasting method utilized, wake behavior and sleep behavior can be modeled with a minimum accuracy of 84%. Additionally, normalizing the wake and sleep scores drastically improves the accuracy to 99%. The results show that we can effectively model wake and sleep behaviors in a smart environment. Furthermore, wake behaviors can be predicted from sleep behaviors and vice versa.

CONTROL OF SLEEP AND WAKEFULNESS

PubMed Central

Brown, Ritchie E.; Basheer, Radhika; McKenna, James T.; Strecker, Robert E.; McCarley, Robert W.

2013-01-01

This review summarizes the brain mechanisms controlling sleep and wakefulness. Wakefulness promoting systems cause low-voltage, fast activity in the electroencephalogram (EEG). Multiple interacting neurotransmitter systems in the brain stem, hypothalamus, and basal forebrain converge onto common effector systems in the thalamus and cortex. Sleep results from the inhibition of wake-promoting systems by homeostatic sleep factors such as adenosine and nitric oxide and GABAergic neurons in the preoptic area of the hypothalamus, resulting in large-amplitude, slow EEG oscillations. Local, activity-dependent factors modulate the amplitude and frequency of cortical slow oscillations. Non-rapid-eye-movement (NREM) sleep results in conservation of brain energy and facilitates memory consolidation through the modulation of synaptic weights. Rapid-eye-movement (REM) sleep results from the interaction of brain stem cholinergic, aminergic, and GABAergic neurons which control the activity of glutamatergic reticular formation neurons leading to REM sleep phenomena such as muscle atonia, REMs, dreaming, and cortical activation. Strong activation of limbic regions during REM sleep suggests a role in regulation of emotion. Genetic studies suggest that brain mechanisms controlling waking and NREM sleep are strongly conserved throughout evolution, underscoring their enormous importance for brain function. Sleep disruption interferes with the normal restorative functions of NREM and REM sleep, resulting in disruptions of breathing and cardiovascular function, changes in emotional reactivity, and cognitive impairments in attention, memory, and decision making. PMID:22811426

Abnormal Sleep/Wake Dynamics in Orexin Knockout Mice

PubMed Central

Diniz Behn, Cecilia G.; Klerman, Elizabeth B.; Mochizuki, Takatoshi; Lin, Shih-Chieh; Scammell, Thomas E.

2010-01-01

Study Objectives: Narcolepsy with cataplexy is caused by a loss of orexin (hypocretin) signaling, but the physiologic mechanisms that result in poor maintenance of wakefulness and fragmented sleep remain unknown. Conventional scoring of sleep cannot reveal much about the process of transitioning between states or the variations within states. We developed an EEG spectral analysis technique to determine whether the state instability in a mouse model of narcolepsy reflects abnormal sleep or wake states, faster movements between states, or abnormal transitions between states. Design: We analyzed sleep recordings in orexin knockout (OXKO) mice and wild type (WT) littermates using a state space analysis technique. This non-categorical approach allows quantitative and unbiased examination of sleep/wake states and state transitions. Measurements and Results: OXKO mice spent less time in deep, delta-rich NREM sleep and in active, theta-rich wake and instead spent more time near the transition zones between states. In addition, while in the midst of what should be stable wake, OXKO mice initiated rapid changes into NREM sleep with high velocities normally seen only in transition regions. Consequently, state transitions were much more frequent and rapid even though the EEG progressions during state transitions were normal. Conclusions: State space analysis enables visualization of the boundaries between sleep and wake and shows that narcoleptic mice have less distinct and more labile states of sleep and wakefulness. These observations provide new perspectives on the abnormal state dynamics resulting from disrupted orexin signaling and highlight the usefulness of state space analysis in understanding narcolepsy and other sleep disorders. Citation: Diniz Behn CG; Klerman EB; Mochizuki T; Lin S; Scammell TE. Abnormal sleep/wake dynamics in orexin knockout mice. SLEEP 2010;33(3):297-306. PMID:20337187

Science: The Islamic Legacy.

ERIC Educational Resources Information Center

Lunde, Paul; And Others

1986-01-01

In the wake of the first space voyage and in-flight experiments by a Muslim astronaut, this document focuses upon the story of Islamic science through the ages. It is intended to demonstrate the resurgence of scientific research and technological development in the Muslim world. The booklet contains chapters on: (1) science: the Islamic legacy;…

Tomo-PIV measurements of the flow field in the wake of a sphere

NASA Astrophysics Data System (ADS)

Eshbal, Lior; David, Tom; Rinsky, Vladislav; van Hout, Rene; Greenblatt, David

2017-11-01

A sphere can be considered as a prototypical 3D bluff body. In order to improve our understanding of its 3D wake flow, a combination of time-resolved planar particle image velocimetry (PIV) and tomographic PIV (tomo-PIV) was implemented. Experiments were performed in a closed-loop water channel facility and sphere Reynolds numbers ReD = UD/ ν = 400, 800, 1200 and 2000, where U is the free-stream velocity, ν the kinematic viscosity and D the sphere diameter. The measurement volume (Height x Length x Width, 5 x 5 x 1.5 D3) comprised the sphere and the downstream wake. Tomo-PIV snap-shots were correlated with the time-resolved PIV such that the 3D temporal evolution of the shed vortices became clear. At ReD = 400, this procedure revealed shed hairpin vortices having a vertical plane of symmetry in agreement with many dye visualization studies. However, the measurements also revealed weaker induced hairpins resulting from the interaction of the near-wake flow and the surrounding free stream. These induced vortices were not visible in previous dye and smoke visualizations and have only been observed in simulations. Data processing of the data at higher ReD is currently ongoing. Israel Science Foundation Grant No. 1596/14.

A Hybrid Model of Mathematics Support for Science Students Emphasizing Basic Skills and Discipline Relevance

ERIC Educational Resources Information Center

Jackson, Deborah C.; Johnson, Elizabeth D.

2013-01-01

The problem of students entering university lacking basic mathematical skills is a critical issue in the Australian higher-education sector and relevant globally. The Maths Skills programme at La Trobe University has been developed to address under preparation in the first-year science cohort in the absence of an institutional mathematics support…

Effect of Self Regulated Learning Approach on Junior Secondary School Students' Achievement in Basic Science

ERIC Educational Resources Information Center

Nwafor, Chika E.; Obodo, Abigail Chikaodinaka; Okafor, Gabriel

2015-01-01

This study explored the effect of self-regulated learning approach on junior secondary school students' achievement in basic science. Quasi-experimental design was used for the study.Two co-educational schools were drawn for the study through simple random sampling technique. One school was assigned to the treatment group while the other was…

Cystic fibrosis research topics featured at the 14th ECFS Basic Science Conference: Chairman's summary.

PubMed

Mall, Marcus A; Hwang, Tzyh-Chang; Braakman, Ineke

2018-03-01

In recent years, tremendous progress has been made in the development of novel drugs targeting the basic defect in patients with cystic fibrosis (CF). This breakthrough is based on a solid foundation of knowledge on CFTR's function in health and how mutations in CFTR cause CF multi-organ disease. This knowledge has been collected and continuously expanded by an active and persistent CF research community and has paved the way for precision medicine for CF. Since 2004, the European Cystic Fibrosis Society (ECFS) has held an annual Basic Science Conference that has evolved as an international forum for interdisciplinary discussion of hot topics and unsolved questions related to CF research. This Special Issue reviews CF research topics featured at the 14th ECFS Basic Science Conference and provides an up-to-date overview of recent progress in our understanding of CFTR structure and function, disease mechanisms implicated in airway mucus plugging, inflammation and abnormal host-pathogen interactions, and advancements with enhanced cell and animal model systems and breakthrough therapies directed at mutant CFTR or alternative targets. In addition, this Special Issue also identifies a number of fundamental questions and hurdles that still have to be overcome to realize the full potential of precision medicine and develop transformative therapies for all patients with CF. Copyright © 2017 European Cystic Fibrosis Society. Published by Elsevier B.V. All rights reserved.

Experimental study on wake structure of single rising clean bubble

NASA Astrophysics Data System (ADS)

Sato, Ayaka; Takedomi, Yuta; Shirota, Minori; Sanada, Toshiyuki; Watanabe, Masao

2007-11-01

Wake structure of clean bubble rising in quiescent silicone oil solution of photochromic dye is experimentally studied. A single bubble is generated, immediately after UV sheet light illuminates the part of the liquid just above the bubble generation nozzle in order to activate photochromic dye. Once the bubble passes across the colored part of the liquid, the bubble is accompanied by some portion of activated dye tracers; hence the flow structure in the rear of the single rising bubble is visualized. We capture stereo images of both wake structure and bubble motion. We study how wake structure changes with the increase in bubble size. We observe the stable axisymmetric wake structure, which is called `standing eddy' when bubble size is relatively small, and then wake structure becomes unstable and starts to oscillate with the increase in bubble size. With further increase in bubble size, a pair of streamwise vortices, which is called `double thread', is observed. We discuss in detail this transition from the steady wake to unsteady wake structure, especially double thread wake development and hairpin vortices shedding, in relation to the transition from rectilinear to spiral or zigzag bubble motions.

Optimization Under Uncertainty for Wake Steering Strategies: Preprint

DOE Office of Scientific and Technical Information (OSTI.GOV)

Quick, Julian; Annoni, Jennifer; King, Ryan N

Wind turbines in a wind power plant experience significant power losses because of aerodynamic interactions between turbines. One control strategy to reduce these losses is known as 'wake steering,' in which upstream turbines are yawed to direct wakes away from downstream turbines. Previous wake steering research has assumed perfect information, however, there can be significant uncertainty in many aspects of the problem, including wind inflow and various turbine measurements. Uncertainty has significant implications for performance of wake steering strategies. Consequently, the authors formulate and solve an optimization under uncertainty (OUU) problem for finding optimal wake steering strategies in the presencemore » of yaw angle uncertainty. The OUU wake steering strategy is demonstrated on a two-turbine test case and on the utility-scale, offshore Princess Amalia Wind Farm. When we accounted for yaw angle uncertainty in the Princess Amalia Wind Farm case, inflow-direction-specific OUU solutions produced between 0% and 1.4% more power than the deterministically optimized steering strategies, resulting in an overall annual average improvement of 0.2%. More importantly, the deterministic optimization is expected to perform worse and with more downside risk than the OUU result when realistic uncertainty is taken into account. Additionally, the OUU solution produces fewer extreme yaw situations than the deterministic solution.« less

Visualization of the wake behind a sliding bubble

NASA Astrophysics Data System (ADS)

O'Reilly Meehan, R.; Grennan, K.; Davis, I.; Nolan, K.; Murray, D. B.

2017-10-01

In this work, Schlieren measurements are presented for the wake of an air bubble sliding under a heated, inclined surface in quiescent water to provide new insights into the intricate sliding bubble wake structure and the associated convective cooling process. This is a two-phase flow configuration that is pertinent to thermal management solutions, where the fundamental flow physics have yet to be fully described. In this work, we present an experimental apparatus that enables high-quality Schlieren images for different bubble sizes and measurement planes. By combining these visualizations with an advanced bubble tracking technique, we can simultaneously quantify the symbiotic relationship that exists between the sliding bubble dynamics and its associated wake. An unstable, dynamic wake structure is revealed, consisting of multiple hairpin-shaped vortex structures interacting within the macroscopic area affected by the bubble. As vorticity is generated in the near wake, the bubble shape is observed to recoil and rebound. This also occurs normal to the surface and is particularly noticeable for larger bubble sizes, with a periodic ejection of material from the near wake corresponding to significant shape changes. These findings, along with their implications from a thermal management perspective, provide information on the rich dynamics of this natural flow that cannot be obtained using alternate experimental techniques.

Sleep-wake disturbances in sporadic Creutzfeldt-Jakob disease.

PubMed

Landolt, H-P; Glatzel, M; Blättler, T; Achermann, P; Roth, C; Mathis, J; Weis, J; Tobler, I; Aguzzi, A; Bassetti, C L

2006-05-09

The prevalence and characteristics of sleep-wake disturbances in sporadic Creutzfeldt-Jakob disease (sCJD) are poorly understood. Seven consecutive patients with definite sCJD underwent a systematic assessment of sleep-wake disturbances, including clinical history, video-polysomnography, and actigraphy. Extent and distribution of neurodegeneration was estimated by brain autopsy in six patients. Western blot analyses enabling classification and quantification of the protease-resistant isoform of the prion protein, PrPSc, in thalamus and occipital cortex was available in four patients. Sleep-wake symptoms were observed in all patients, and were prominent in four of them. All patients had severe sleep EEG abnormalities with loss of sleep spindles, very low sleep efficiency, and virtual absence of REM sleep. The correlation between different methods to assess sleep-wake functions (history, polysomnography, actigraphy, videography) was generally poor. Brain autopsy revealed prominent changes in cortical areas, but only mild changes in the thalamus. No mutation of the PRNP gene was found. This study demonstrates in sporadic Creutzfeldt-Jakob disease, first, the existence of sleep-wake disturbances similar to those reported in fatal familial insomnia in the absence of prominent and isolated thalamic neuronal loss, and second, the need of a multimodal approach for the unambiguous assessment of sleep-wake functions in these patients.

Wind Wake Watcher v. 1.0

DOE Office of Scientific and Technical Information (OSTI.GOV)

Martin, Shawn

This software enables the user to produce Google Earth visualizations of turbine wake effects for wind farms. The visualizations are based on computations of statistical quantities that vary with wind direction and help quantify the effects on power production of upwind turbines on turbines in their wakes. The results of the software are plot images and kml files that can be loaded into Google Earth. The statistics computed are described in greater detail in the paper: S. Martin, C. H. Westergaard, and J. White (2016), Visualizing Wind Farm Wakes Using SCADA Data, in Wither Turbulence and Big Data in themore » 21st Century? Eds. A. Pollard, L. Castillo, L. Danaila, and M. Glauser. Springer, pgs. 231-254.« less

Teaching Basic Science Environmentally, Concept: Water that Comes Down as Rain Is Used Over and Over Again.

ERIC Educational Resources Information Center

Busch, Phyllis S.

1985-01-01

Provides directions for basic science experiments which demonstrate the rain cycle, fundamentals of cloud formation, and testing for the presence of acidity in local rainwater. Describes materials required, step-by-step instructions, and discussion topics. (NEC)

Wind turbine wake characterization using long-range Doppler lidar

NASA Astrophysics Data System (ADS)

Aitken, M.; Lundquist, J. K.; Hestmark, K.; Banta, R. M.; Pichugina, Y.; Brewer, A.

2012-12-01

Wind turbines extract energy from the freestream flow, resulting in a waked region behind the rotor which is characterized by reduced wind speed and increased turbulence. The velocity deficit in the wake diminishes with distance, as faster-moving air outside is gradually entrained. In a concentrated group of turbines, then, downwind machines experience very different inflow conditions compared to those in the front row. As utility-scale turbines rarely exist in isolation, detailed knowledge of the mean flow and turbulence structure inside wakes is needed to correctly model both power production and turbine loading at modern wind farms. To this end, the Turbine Wake and Inflow Characterization Study (TWICS) was conducted in the spring of 2011 to determine the reduction in wind speeds downstream from a multi-MW turbine located at the National Renewable Energy Laboratory's National Wind Technology Center (NWTC) near Boulder, Colorado. Full-scale measurements of wake dynamics are hardly practical or even possible with conventional sensors, such as cup anemometers mounted on meteorological (met) masts. Accordingly, the High Resolution Doppler Lidar (HRDL) developed by the National Oceanic and Atmospheric Administration's Earth System Research Laboratory was employed to investigate the formation and propagation of wakes under varying levels of ambient wind speed, shear, atmospheric stability, and turbulence. HRDL remotely senses line-of-sight wind velocities and has been used in several previous studies of boundary layer aerodynamics. With a fully steerable beam and a maximum range up to about 5 km, depending on atmospheric conditions, HRDL performed a comprehensive survey of the wind flow in front of and behind the turbine to study the shape, meandering, and attenuation of wakes. Due in large part to limited experimental data availability, wind farm wake modeling is still subject to an unacceptable amount of uncertainty, particularly in complex terrain. Here, analytical

Rotor wake characteristics of a transonic axial flow fan

NASA Technical Reports Server (NTRS)

Hathaway, M. D.; Gertz, J.; Epstein, A.; Strazisar, A. J.

1985-01-01

State of the art turbomachinery flow analysis codes are not capable of predicting the viscous flow features within turbomachinery blade wakes. Until efficient 3D viscous flow analysis codes become a reality there is therefore a need for models which can describe the generation and transport of blade wakes and the mixing process within the wake. To address the need for experimental data to support the development of such models, high response pressure measurements and laser anemometer velocity measurements were obtained in the wake of a transonic axial flow fan rotor.

Neuroligin-1 links neuronal activity to sleep-wake regulation.

PubMed

El Helou, Janine; Bélanger-Nelson, Erika; Freyburger, Marlène; Dorsaz, Stéphane; Curie, Thomas; La Spada, Francesco; Gaudreault, Pierre-Olivier; Beaumont, Éric; Pouliot, Philippe; Lesage, Frédéric; Frank, Marcos G; Franken, Paul; Mongrain, Valérie

2013-06-11

Maintaining wakefulness is associated with a progressive increase in the need for sleep. This phenomenon has been linked to changes in synaptic function. The synaptic adhesion molecule Neuroligin-1 (NLG1) controls the activity and synaptic localization of N-methyl-d-aspartate receptors, which activity is impaired by prolonged wakefulness. We here highlight that this pathway may underlie both the adverse effects of sleep loss on cognition and the subsequent changes in cortical synchrony. We found that the expression of specific Nlg1 transcript variants is changed by sleep deprivation in three mouse strains. These observations were associated with strain-specific changes in synaptic NLG1 protein content. Importantly, we showed that Nlg1 knockout mice are not able to sustain wakefulness and spend more time in nonrapid eye movement sleep than wild-type mice. These changes occurred with modifications in waking quality as exemplified by low theta/alpha activity during wakefulness and poor preference for social novelty, as well as altered delta synchrony during sleep. Finally, we identified a transcriptional pathway that could underlie the sleep/wake-dependent changes in Nlg1 expression and that involves clock transcription factors. We thus suggest that NLG1 is an element that contributes to the coupling of neuronal activity to sleep/wake regulation.

Vitamin B12 treatment for sleep-wake rhythm disorders.

PubMed

Okawa, M; Mishima, K; Nanami, T; Shimizu, T; Iijima, S; Hishikawa, Y; Takahashi, K

1990-02-01

Vitamin B12 (VB12) was administered to two patients suffering for many years from different sleep-wake rhythm disorders. One patient was a 15-year-old blind girl suffering from a free-running sleep-wake rhythm (hypernychthemeral syndrome) with a period of about 25 h. In spite of repeated trials to entrain her sleep-wake cycle to the environmental 24-h rhythm, her free-running rhythm persisted for about 13 years. When she was 14 years old, administration of VB12 per os was started at the daily dose of 1.5 mg t.i.d. Shortly thereafter, her sleep-wake rhythm was entrained to the environmental 24-h rhythm, and her 24-h sleep-wake rhythm was maintained while she was on the medication. Within 2 months of the withholding of VB12, her free-running sleep-wake rhythm reappeared. The VB12 level in the serum was within the normal range both before and after treatment. The other patient was a 55-year-old man suffering from delayed sleep phase syndrome since 18 years of age. After administration of VB12 at the daily doses of 1.5 mg, his sleep-wake rhythm disorder was improved. The good therapeutic effect lasted for more than 6 months while he was on the medication.

Neuroligin-1 links neuronal activity to sleep-wake regulation

PubMed Central

El Helou, Janine; Bélanger-Nelson, Erika; Freyburger, Marlène; Dorsaz, Stéphane; Curie, Thomas; La Spada, Francesco; Gaudreault, Pierre-Olivier; Beaumont, Éric; Pouliot, Philippe; Lesage, Frédéric; Frank, Marcos G.; Franken, Paul; Mongrain, Valérie

2013-01-01

Maintaining wakefulness is associated with a progressive increase in the need for sleep. This phenomenon has been linked to changes in synaptic function. The synaptic adhesion molecule Neuroligin-1 (NLG1) controls the activity and synaptic localization of N-methyl-d-aspartate receptors, which activity is impaired by prolonged wakefulness. We here highlight that this pathway may underlie both the adverse effects of sleep loss on cognition and the subsequent changes in cortical synchrony. We found that the expression of specific Nlg1 transcript variants is changed by sleep deprivation in three mouse strains. These observations were associated with strain-specific changes in synaptic NLG1 protein content. Importantly, we showed that Nlg1 knockout mice are not able to sustain wakefulness and spend more time in nonrapid eye movement sleep than wild-type mice. These changes occurred with modifications in waking quality as exemplified by low theta/alpha activity during wakefulness and poor preference for social novelty, as well as altered delta synchrony during sleep. Finally, we identified a transcriptional pathway that could underlie the sleep/wake-dependent changes in Nlg1 expression and that involves clock transcription factors. We thus suggest that NLG1 is an element that contributes to the coupling of neuronal activity to sleep/wake regulation. PMID:23716671

Vortex wake alleviation studies with a variable twist wing

NASA Technical Reports Server (NTRS)

Holbrook, G. T.; Dunham, D. M.; Greene, G. C.

1985-01-01

Vortex wake alleviation studies were conducted in a wind tunnel and a water towing tank using a multisegmented wing model which provided controlled and measured variations in span load. Fourteen model configurations are tested at a Reynolds number of one million and a lift coefficient of 0.6 in the Langley 4- by 7-Meter Tunnel and the Hydronautics Ship Model Basin water tank at Hydronautics, Inc., Laurel, Md. Detailed measurements of span load and wake velocities at one semispan downstream correlate well with each other, with inviscid predictions of span load and wake roll up, and with peak trailing-wing rolling moments measured in the far wake. Average trailing-wing rolling moments are found to be an unreliable indicator of vortex wake intensity because vortex meander does not scale between test facilities and free-air conditions. A tapered-span-load configuration, which exhibits little or no drag penalty, is shown to offer significant downstream wake alleviation to a small trailing wing. The greater downstream wake alleviation achieved with the addition of spoilers to a flapped-wing configuration is shown to result directly from the high incremental drag and turbulence associated with the spoilers and not from the span load alteration they cause.

Aircraft Vortex Wake Descent and Decay under Real Atmospheric Effects

DOT National Transportation Integrated Search

1973-10-01

Aircraft vortex wake descent and decay in a real atmosphere is studied analytically. Factors relating to encounter hazard, wake generation, wake descent and stability, and atmospheric dynamics are considered. Operational equations for encounter hazar...

Abnormal sleep/wake dynamics in orexin knockout mice.

PubMed

Diniz Behn, Cecilia G; Klerman, Elizabeth B; Mochizuki, Takatoshi; Lin, Shih-Chieh; Scammell, Thomas E

2010-03-01

Narcolepsy with cataplexy is caused by a loss of orexin (hypocretin) signaling, but the physiologic mechanisms that result in poor maintenance of wakefulness and fragmented sleep remain unknown. Conventional scoring of sleep cannot reveal much about the process of transitioning between states or the variations within states. We developed an EEG spectral analysis technique to determine whether the state instability in a mouse model of narcolepsy reflects abnormal sleep or wake states, faster movements between states, or abnormal transitions between states. We analyzed sleep recordings in orexin knockout (OXKO) mice and wild type (WT) littermates using a state space analysis technique. This non-categorical approach allows quantitative and unbiased examination of sleep/wake states and state transitions. OXKO mice spent less time in deep, delta-rich NREM sleep and in active, theta-rich wake and instead spent more time near the transition zones between states. In addition, while in the midst of what should be stable wake, OXKO mice initiated rapid changes into NREM sleep with high velocities normally seen only in transition regions. Consequently, state transitions were much more frequent and rapid even though the EEG progressions during state transitions were normal. State space analysis enables visualization of the boundaries between sleep and wake and shows that narcoleptic mice have less distinct and more labile states of sleep and wakefulness. These observations provide new perspectives on the abnormal state dynamics resulting from disrupted orexin signaling and highlight the usefulness of state space analysis in understanding narcolepsy and other sleep disorders.

Reinventing Biostatistics Education for Basic Scientists

PubMed Central

Weissgerber, Tracey L.; Garovic, Vesna D.; Milin-Lazovic, Jelena S.; Winham, Stacey J.; Obradovic, Zoran; Trzeciakowski, Jerome P.; Milic, Natasa M.

2016-01-01

Numerous studies demonstrating that statistical errors are common in basic science publications have led to calls to improve statistical training for basic scientists. In this article, we sought to evaluate statistical requirements for PhD training and to identify opportunities for improving biostatistics education in the basic sciences. We provide recommendations for improving statistics training for basic biomedical scientists, including: 1. Encouraging departments to require statistics training, 2. Tailoring coursework to the students’ fields of research, and 3. Developing tools and strategies to promote education and dissemination of statistical knowledge. We also provide a list of statistical considerations that should be addressed in statistics education for basic scientists. PMID:27058055

Tracking and Characterization of Aircraft Wakes Using Acoustic and Lidar Measurements

NASA Technical Reports Server (NTRS)

Booth, Earl R., Jr.; Humphreys, William M., Jr.

2005-01-01

Data from the 2003 Denver International Airport Wake Acoustics Test are further examined to discern spectral content of aircraft wake signatures, and to compare three dimensional wake tracking from acoustic data to wake tracking data obtained through use of continuous wave and pulsed lidar. Wake tracking data derived from acoustic array data agree well with both continuous wave and pulsed lidar in the horizontal plane, but less well with pulsed lidar in the vertical direction. Results from this study show that the spectral distribution of acoustic energy in a wake signature varies greatly with aircraft type.

Simulated Wake Characteristics Data for Closely Spaced Parallel Runway Operations Analysis

NASA Technical Reports Server (NTRS)

Guerreiro, Nelson M.; Neitzke, Kurt W.

2012-01-01

A simulation experiment was performed to generate and compile wake characteristics data relevant to the evaluation and feasibility analysis of closely spaced parallel runway (CSPR) operational concepts. While the experiment in this work is not tailored to any particular operational concept, the generated data applies to the broader class of CSPR concepts, where a trailing aircraft on a CSPR approach is required to stay ahead of the wake vortices generated by a lead aircraft on an adjacent CSPR. Data for wake age, circulation strength, and wake altitude change, at various lateral offset distances from the wake-generating lead aircraft approach path were compiled for a set of nine aircraft spanning the full range of FAA and ICAO wake classifications. A total of 54 scenarios were simulated to generate data related to key parameters that determine wake behavior. Of particular interest are wake age characteristics that can be used to evaluate both time- and distance- based in-trail separation concepts for all aircraft wake-class combinations. A simple first-order difference model was developed to enable the computation of wake parameter estimates for aircraft models having weight, wingspan and speed characteristics similar to those of the nine aircraft modeled in this work.

Forecasting Behavior in Smart Homes Based on Sleep and Wake Patterns

PubMed Central

Williams, Jennifer A.; Cook, Diane J.

2017-01-01

Background The goal of this research is to use smart home technology to assist people who are recovering from injuries or coping with disabilities to live independently. Objective We introduce an algorithm to model and forecast wake and sleep behaviors that are exhibited by the participant. Furthermore, we propose that sleep behavior is impacted by and can be modeled from wake behavior, and vice versa. Methods This paper describes the Behavior Forecasting (BF) algorithm. BF consists of 1) defining numeric values that reflect sleep and wake behavior, 2) forecasting wake and sleep values from past behavior, 3) analyzing the effect of wake behavior on sleep and vice versa, and 4) improving prediction performance by using both wake and sleep scores. Results The BF method was evaluated with data collected from 20 smart homes. We found that regardless of the forecasting method utilized, wake behavior and sleep behavior can be modeled with a minimum accuracy of 84%. Additionally, normalizing the wake and sleep scores drastically improves the accuracy to 99%. Conclusions The results show that we can effectively model wake and sleep behaviors in a smart environment. Furthermore, wake behaviors can be predicted from sleep behaviors and vice versa. PMID:27689555

Adaptive sleep-wake discrimination for wearable devices.

PubMed

Karlen, Walter; Floreano, Dario

2011-04-01

Sleep/wake classification systems that rely on physiological signals suffer from intersubject differences that make accurate classification with a single, subject-independent model difficult. To overcome the limitations of intersubject variability, we suggest a novel online adaptation technique that updates the sleep/wake classifier in real time. The objective of the present study was to evaluate the performance of a newly developed adaptive classification algorithm that was embedded on a wearable sleep/wake classification system called SleePic. The algorithm processed ECG and respiratory effort signals for the classification task and applied behavioral measurements (obtained from accelerometer and press-button data) for the automatic adaptation task. When trained as a subject-independent classifier algorithm, the SleePic device was only able to correctly classify 74.94 ± 6.76% of the human-rated sleep/wake data. By using the suggested automatic adaptation method, the mean classification accuracy could be significantly improved to 92.98 ± 3.19%. A subject-independent classifier based on activity data only showed a comparable accuracy of 90.44 ± 3.57%. We demonstrated that subject-independent models used for online sleep-wake classification can successfully be adapted to previously unseen subjects without the intervention of human experts or off-line calibration.

Modifying Ship Air-Wake Vortices for Aircraft Operations

NASA Technical Reports Server (NTRS)

Lamar, John E.

2004-01-01

Columnar-vortex generators (CVG) have been proposed as means to increase the safety of takeoffs and landings of aircraft on aircraft or helicopter carriers and other ships at sea. According to the proposal, CVGs would be installed at critical edge locations on ships to modify the vortices in the air wakes of the ships. The desired effects of modifications are to smooth airflows over takeoff and landing deck areas and divert vortices from takeoff and landing flight paths. With respect to aircraft operations, the wake flows of primary interest are those associated with the bow and side edges of aircraft-carrier decks and with superstructures of ships in general (see Figure 1). The bow and deck-edge vortices can adversely affect airplane and helicopter operations on carriers, while the superstructure wakes can primarily affect operations of helicopters. The concept of the CVG is not new; what is new is the proposed addition of CVGs to ship structures to effect favorable modifications of air wakes. Figure 2 depicts a basic CVG, vertical and horizontal CVGs installed on a simple superstructure, and horizontal CVGs installed on the bow and deck edges. The vertical CVGs would be closed at the deck but open at the top. Each horizontal CVG would be open at both ends. The dimensions of the CVGs installed on the aft edges of the superstructure would be chosen so that the portion of the flow modified by the vertical CVGs would interact synergistically with the portion of the flow modified by the horizontal CVG to move the air wake away from the takeoff-and-landing zone behind the superstructure. The deck-edge CVGs would be mounted flush with, and would extend slightly ahead of the bow of, the flight deck. The overall length of each tube would exceed that of the flight deck. Each deck-edge CVG would capture that portion of the airflow that generates a deck-edge vortex and would generate a columnar vortex of opposite sense to that of the unmodified vortex. The vortex generated

Functional anatomy of the sleep-wakefulness cycle: wakefulness.

PubMed

Reinoso-Suárez, Fernando; de Andrés, Isabel; Garzón, Miguel

2011-01-01

Sleep is a necessary, diverse, periodic, and an active condition circadian and homeostatically regulated and precisely meshed with waking time into the sleep-wakefulness cycle (SWC). Photic retinal stimulation modulates the suprachiasmatic nucleus, which acts as the pacemaker for SWC rhythmicity. Both the light period and social cues adjust the internal clock, making the SWC a circadian, 24-h period in the adult human. Bioelectrical and behavioral parameters characterize the different phases of the SWC. For a long time, lesions and electrical stimulation of brain structures, as well as connection studies, were the main methods used to decipher the foundations of the functional anatomy of the SWC. That is why the first section of this review presents these early historical studies to then discuss the current state of our knowledge based on our understanding of the functional anatomy of the structures underlying the SWC. Supported by this description, we then present a detailed review and update of the structures involved in the phase of wakefulness (W), including their morphological, functional, and chemical characteristics, as well as their anatomical connections. The structures for W generation are known as the "ascending reticular activating system", and they keep and maintain the "thalamo-cerebral cortex unit" awake. This system originates from the neuronal groups located within the brainstem, hypothalamus, and basal forebrain, which use known neurotransmitters and whose neurons are more active during W than during the other SWC states. Thus, synergies among several of these neurotransmitters are necessary to generate the cortical and thalamic activation that is characteristic of the W state, with all the plastic qualities and nuances present in its different behavioral circumstances. Each one of the neurotransmitters exerts powerful influences on the information and cognitive processes as well as attentional, emotional, motivational, behavioral, and arousal

32 CFR 707.10 - Wake illumination light.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 32 National Defense 5 2010-07-01 2010-07-01 false Wake illumination light. 707.10 Section 707.10 National Defense Department of Defense (Continued) DEPARTMENT OF THE NAVY NAVIGATION SPECIAL RULES WITH... display a white spot light located near the stern to illuminate the wake. ...

Accommodating Adolescent Sleep-Wake Patterns: The Effects of Shifting the Timing of Sleep on Training Effectiveness

PubMed Central

Miller, Nita Lewis; Tvaryanas, Anthony P.; Shattuck, Lawrence G.

2012-01-01

Study Objective: This study evaluated the effect of accommodating adolescent sleep-wake patterns by altering the timing of the major sleep period of US Army recruits. Design: The quasi-experimental study compared recruits assigned to one of two training companies: one with a customary sleep regimen (20:30 to 04:30) while the other employed a phase-delayed sleep regimen (23:00 to 07:00), the latter aligning better with biologically driven sleep-wake patterns of adolescents. Setting: The study was conducted during Basic Combat Training (BCT) at Fort Leonard Wood, Missouri. Trainees: The study included 392 trainees: 209 received the intervention, while 183 composed the Comparison group. Measurements and Results: Demographic and psychophysiological measures were collected on all trainees. Weekly assessments of subjective fatigue and mood, periodic physical fitness, marksmanship scores, and attrition rates from BCT were studied. Actigraphy was collected on approximately 24% of trainees. Based on actigraphy, trainees on the phase-delayed sleep schedule obtained 31 m more sleep/night than trainees on the customary sleep schedule. The Intervention group reported less total mood disturbance relative to baseline. Improvements in marksmanship correlated positively with average nightly sleep during the preceding week when basic marksmanship skills were taught. No differences were seen in physical fitness or attrition rates. In contrast to the Intervention group, the Comparison group was 2.3 times more likely to experience occupationally significant fatigue and 5.5 times more likely to report poor sleep quality. Conclusions: Accommodating adolescent sleep patterns significantly improves mental health and performance in the training environment. Citation: Miller NL; Tvaryanas AP; Shattuck LG. Accommodating adolescent sleep-wake patterns: the effects of shifting the timing of sleep on training effectiveness. SLEEP 2012;35(8):1123-1136. PMID:22851808

Some wake-related operational limitations of rotorcraft

NASA Technical Reports Server (NTRS)

Heyson, H. H.

1980-01-01

Wind tunnel measurements show that the wake of a rotor, except at near hovering speeds, is not like that of a propeller. The wake is more like that of a wing except that, because of the slow speeds, the wake velocities may be much greater. The helicopter can produce a wake hazard to following light aircraft that is disproportionately great compared to an equivalent fixed wing aircraft. This hazard should be recognized by both pilots and airport controllers when operating in congested areas. Ground effect is generally counted as a blessing since it allows overloaded takeoffs; however, it also introduces additional operation problems. These problems include premature blade stall in hover, settling in forward transition, shuddering in approach to touchdown and complicatons with yaw control. Some of these problems were treated analytically in an approximate manner and reasonable experiment agreement was obtained. An awareness of these effects can prepare the user for their appearance and their consequences.

Wind Turbine Wake Experiment - Wieringermeer (WINTWEX-W)

NASA Astrophysics Data System (ADS)

Kumer, V. M.; Reuder, J.; Svardal, B.; Eecen, P.

2014-12-01

WINTWEX-W is a cooperative wake measurement campaign conducted by the Norwegian Centre of Offshore Wind Energy (Norcowe) and the Energy Research Centre of the Netherlands (ECN). A scanning, four static Windcubes as well as a downstream looking nacelle LiDAR were placed for half a year downstream of one of five research wind turbines in ECNs' wind turbine test farm Wieringermeer. In order to capture wake characteristics under different weather conditions we scanned a 60˚ sector at three different elevations and two vertical cross-sections every minute. Windcubes v1 measured wind profiles every second at 2, 5 and 12 rotor diameter downstream distances. Another static Windcube, a forward-looking nacelle LiDAR and three Sonics were placed upstream to measure the undisturbed approaching flow field. The aim of the campaign is a qualitative and quantitative description of single wind turbine wake propagation and persistency, as well as to improve CFD wake models by delivering a detailed data set of several real atmospheric conditions.

Wake coupling to full potential rotor analysis code

NASA Technical Reports Server (NTRS)

Torres, Francisco J.; Chang, I-Chung; Oh, Byung K.

1990-01-01

The wake information from a helicopter forward flight code is coupled with two transonic potential rotor codes. The induced velocities for the near-, mid-, and far-wake geometries are extracted from a nonlinear rigid wake of a standard performance and analysis code. These, together with the corresponding inflow angles, computation points, and azimuth angles, are then incorporated into the transonic potential codes. The coupled codes can then provide an improved prediction of rotor blade loading at transonic speeds.

A Study of Wake Development and Structure in Constant Pressure Gradients

NASA Technical Reports Server (NTRS)

Thomas, Flint O.; Nelson, R. C.; Liu, Xiaofeng

2000-01-01

Motivated by the application to high-lift aerodynamics for commercial transport aircraft, a systematic investigation into the response of symmetric/asymmetric planar turbulent wake development to constant adverse, zero, and favorable pressure gradients has been conducted. The experiments are performed at a Reynolds number of 2.4 million based on the chord of the wake generator. A unique feature of this wake study is that the pressure gradients imposed on the wake flow field are held constant. The experimental measurements involve both conventional LDV and hot wire flow field surveys of mean and turbulent quantities including the turbulent kinetic energy budget. In addition, similarity analysis and numerical simulation have also been conducted for this wake study. A focus of the research has been to isolate the effects of both pressure gradient and initial wake asymmetry on the wake development. Experimental results reveal that the pressure gradient has a tremendous influence on the wake development, despite the relatively modest pressure gradients imposed. For a given pressure gradient, the development of an initially asymmetric wake is different from the initially symmetric wake. An explicit similarity solution for the shape parameters of the symmetric wake is obtained and agrees with the experimental results. The turbulent kinetic energy budget measurements of the symmetric wake demonstrate that except for the convection term, the imposed pressure gradient does not change the fundamental flow physics of turbulent kinetic energy transport. Based on the turbulent kinetic energy budget measurements, an approach to correct the bias error associated with the notoriously difficult dissipation estimate is proposed and validated through the comparison of the experimental estimate with a direct numerical simulation result.

Modeling the effects of caffeine on the sleep/ wake cycle.

PubMed

Daniello, Allison; Fievisohn, Elizabeth; Gregory, T Stan

2012-01-01

Caffeine is present in many products consumed daily, including coffee, soda, and chocolate, and is known to delay the onset of sleepiness and cause sleep disturbances. It is an adenosine antagonist, inhibiting some hormones that promote sleep, and therefore promoting wakefulness. This paper proposes a model to incorporate the effects of caffeine on the sleep/wake cycle. The “flip-flop” model was used to model the sleep cycle, where switching between a sleep state and a wake state was nearly instantaneous. Sleep patterns were modeled based on the circadian rhythm and homeostatic drive, as was done by Rempe et al. (2010). The model demonstrated how the homeostatic drive and circadian rhythm interact to cause sleep and wakefulness. The effects of caffeine were incorporated to have a masking effect on the homeostatic drive, promoting wakefulness. Preliminary results showed that caffeine intake late in the evening caused the switch from wake to sleep to occur later than if no caffeine was present in the system. Additionally, the switch from wake to sleep was increasingly delayed with increased caffeine intake at the same time. This model is not yet validated, though potential studies for validation are proposed. This model presents an interesting method for incorporating the effects of caffeine on the sleep/wake cycle.

Observations of the trade wind wakes of Kauai and Oahu

NASA Astrophysics Data System (ADS)

Yang, Yang; Ma, Jian; Xie, Shang-Ping

2008-02-01

The Hawaiian islands of Kauai and Oahu stand in the path of the east-northeasterly trade winds, creating wakes in the lee. For the first time, the structure of the wakes and their diurnal cycle were observed on a cruise during 18-20 December 2006. The dynamic wakes, characterized by reduced trades, extend about 1 km in height with strong wind shear at the top. Thermal forcing of these small islands also affects the wake circulations. Sea breezes develop in the afternoon turning the winds into westerly near the shore in the wakes. At night, land breezes advect cool air from the islands, creating a shallow cool layer between the sea surface and a capping inversion. The warming in the wake in the afternoon extends much deeper (1.4 km) than the cool layer (0.5 km) at night. The effect of diurnal changes on cloud formation in the wakes is discussed, and the sharp variations in wind velocity lee of the islands may affect ocean currents, waves and mixing.

The Views of Science Pre-Service Teachers about the Usage of Basic Information Technologies (BIT) in Education and Instruction

ERIC Educational Resources Information Center

Çetin, Oguz

2016-01-01

In this study aiming to present a description based on science pre-service teachers' views related to use of Basic Information Technologies (BIT) in education and training, an interview is carried out with 21 pre-service science teachers who study in different classes in Faculty of Education, Nigde University. For this aim, improved interview form…

Basic research needs to assure a secure energy future. A report from the Basic Energy Sciences Advisory Committee

DOE Office of Scientific and Technical Information (OSTI.GOV)

None

This report has highlighted many of the possible fundamental research areas that will help our country avoid a future energy crisis. The report may not have adequately captured the atmosphere of concern that permeated the discussions at the workshop. The difficulties facing our nation and the world in meeting our energy needs over the next several decades are very challenging. It was generally felt that traditional solutions and approaches will not solve the total energy problem. Knowledge that does not exist must be obtained to address both the quantity of energy needed to increase the standard of living world-wide andmore » the quality of energy generation needed to preserve the environment. In terms of investments, it was clear that there is no single research area that will secure the future energy supply. A diverse range of economic energy sources will be required--and a broad range of fundamental research is needed to enable these. Many of the issues fall into the traditional materials and chemical sciences research areas, but with specific emphasis on understanding mechanisms, energy related phenomena, and pursuing novel directions in, for example, nanoscience and integrated modeling. An important result from the discussions, which is hopefully apparent from the brief presentations above, is that the problems that must be dealt with are truly multidisciplinary. This means that they require the participation of investigators with different skill sets. Basic science skills have to be complemented by awareness of the overall nature of the problem in a national and world context, and with knowledge of the engineering, design, and control issues in any eventual solution. It is necessary to find ways in which this can be done while still preserving the ability to do first-class basic science. The traditional structure of research, with specific disciplinary groupings, will not be sufficient. This presents great challenges and opportunities for the funders of the

What is Basic Research? Insights from Historical Semantics.

PubMed

Schauz, Désirée

2014-01-01

For some years now, the concept of basic research has been under attack. Yet although the significance of the concept is in doubt, basic research continues to be used as an analytical category in science studies. But what exactly is basic research? What is the difference between basic and applied research? This article seeks to answer these questions by applying historical semantics. I argue that the concept of basic research did not arise out of the tradition of pure science. On the contrary, this new concept emerged in the late 19th and early 20th centuries, a time when scientists were being confronted with rising expectations regarding the societal utility of science. Scientists used the concept in order to try to bridge the gap between the promise of utility and the uncertainty of scientific endeavour. Only after 1945, when United States science policy shaped the notion of basic research, did the concept revert to the older ideals of pure science. This revival of the purity discourse was caused by the specific historical situation in the US at that time: the need to reform federal research policy after the Second World War, the new dimension of ethical dilemmas in science and technology during the atomic era, and the tense political climate during the Cold War.

On the Effects of Wind Turbine Wake Skew Caused by Wind Veer

DOE Office of Scientific and Technical Information (OSTI.GOV)

Churchfield, Matthew J; Sirnivas, Senu

Because of Coriolis forces caused by the Earth's rotation, the structure of the atmospheric boundary layer often contains wind-direction change with height, also known as wind-direction veer. Under low turbulence conditions, such as in stably stratified atmospheric conditions, this veer can be significant, even across the vertical extent of a wind turbine's rotor disk. The veer then causes the wind turbine wake to skew as it advects downstream. This wake skew has been observed both experimentally and numerically. In this work, we attempt to examine the wake skewing process in some detail, and quantify how differently a skewed wake versusmore » a non skewed wake affects a downstream turbine. We do this by performing atmospheric large-eddy simulations to create turbulent inflow winds with and without veer. In the veer case, there is a roughly 8 degree wind direction change across the turbine rotor. We then perform subsequent large-eddy simulations using these inflow data with an actuator line rotor model to create wakes. The turbine modeled is a large, modern, offshore, multimegawatt turbine. We examine the unsteady wake data in detail and show that the skewed wake recovers faster than the non skewed wake. We also show that the wake deficit does not skew to the same degree that a passive tracer would if subject to veered inflow. Last, we use the wake data to place a hypothetical turbine 9 rotor diameters downstream by running aeroelastic simulations with the simulated wake data. We see differences in power and loads if this downstream turbine is subject to a skewed or non skewed wake. We feel that the differences observed between the skewed and nonskewed wake are important enough that the skewing effect should be included in engineering wake models.« less

Investigating the interaction between the homeostatic and circadian processes of sleep-wake regulation for the prediction of waking neurobehavioural performance

NASA Technical Reports Server (NTRS)

Van Dongen, Hans P A.; Dinges, David F.

2003-01-01

The two-process model of sleep regulation has been applied successfully to describe, predict, and understand sleep-wake regulation in a variety of experimental protocols such as sleep deprivation and forced desynchrony. A non-linear interaction between the homeostatic and circadian processes was reported when the model was applied to describe alertness and performance data obtained during forced desynchrony. This non-linear interaction could also be due to intrinsic non-linearity in the metrics used to measure alertness and performance, however. Distinguishing these possibilities would be of theoretical interest, but could also have important implications for the design and interpretation of experiments placing sleep at different circadian phases or varying the duration of sleep and/or wakefulness. Although to date no resolution to this controversy has been found, here we show that the issue can be addressed with existing data sets. The interaction between the homeostatic and circadian processes of sleep-wake regulation was investigated using neurobehavioural performance data from a laboratory experiment involving total sleep deprivation. The results provided evidence of an actual non-linear interaction between the homeostatic and circadian processes of sleep-wake regulation for the prediction of waking neurobehavioural performance.

Sleep/wake dependent changes in cortical glucose concentrations.

PubMed

Dash, Michael B; Bellesi, Michele; Tononi, Giulio; Cirelli, Chiara

2013-01-01

Most of the energy in the brain comes from glucose and supports glutamatergic activity. The firing rate of cortical glutamatergic neurons, as well as cortical extracellular glutamate levels, increase with time spent awake and decline throughout non rapid eye movement sleep, raising the question whether glucose levels reflect behavioral state and sleep/wake history. Here chronic (2-3 days) electroencephalographic recordings in the rat cerebral cortex were coupled with fixed-potential amperometry to monitor the extracellular concentration of glucose ([gluc]) on a second-by-second basis across the spontaneous sleep-wake cycle and in response to 3 h of sleep deprivation. [Gluc] progressively increased during non rapid eye movement sleep and declined during rapid eye movement sleep, while during wake an early decline in [gluc] was followed by an increase 8-15 min after awakening. There was a significant time of day effect during the dark phase, when rats are mostly awake, with [gluc] being significantly lower during the last 3-4 h of the night relative to the first 3-4 h. Moreover, the duration of the early phase of [gluc] decline during wake was longer after prolonged wake than after consolidated sleep. Thus, the sleep/wake history may affect the levels of glucose available to the brain upon awakening. © 2012 The Authors Journal of Neurochemistry © 2012 International Society for Neurochemistry.

Effect of wakes on land-atmosphere fluxes

NASA Astrophysics Data System (ADS)