AACJC International/Intercultural Consortium Summer Study Programs Overseas, 1979.

ERIC Educational Resources Information Center

Jacobsen, Becky

Responses are presented to a questionnaire on overseas summer programs that was sent in January 1979 to members of the American Association of Community and Junior Colleges (AACJC) International/Intercultural Consortium (IIC). Program descriptions are listed alphabetically by world region and country. Program information includes: name of program,…

Catabolic efficiency of aerobic glycolysis: the Warburg effect revisited.

PubMed

Vazquez, Alexei; Liu, Jiangxia; Zhou, Yi; Oltvai, Zoltán N

2010-05-06

Cancer cells simultaneously exhibit glycolysis with lactate secretion and mitochondrial respiration even in the presence of oxygen, a phenomenon known as the Warburg effect. The maintenance of this mixed metabolic phenotype is seemingly counterintuitive given that aerobic glycolysis is far less efficient in terms of ATP yield per moles of glucose than mitochondrial respiration. Here, we resolve this apparent contradiction by expanding the notion of metabolic efficiency. We study a reduced flux balance model of ATP production that is constrained by the glucose uptake capacity and by the solvent capacity of the cell's cytoplasm, the latter quantifying the maximum amount of macromolecules that can occupy the intracellular space. At low glucose uptake rates we find that mitochondrial respiration is indeed the most efficient pathway for ATP generation. Above a threshold glucose uptake rate, however, a gradual activation of aerobic glycolysis and slight decrease of mitochondrial respiration results in the highest rate of ATP production. Our analyses indicate that the Warburg effect is a favorable catabolic state for all rapidly proliferating mammalian cells with high glucose uptake capacity. It arises because while aerobic glycolysis is less efficient than mitochondrial respiration in terms of ATP yield per glucose uptake, it is more efficient in terms of the required solvent capacity. These results may have direct relevance to chemotherapeutic strategies attempting to target cancer metabolism.

Summer 2014 Marketing Intern Final Report

NASA Technical Reports Server (NTRS)

Pereda-Ramos, Marlee

2014-01-01

As a summer 2014 Marketing Intern for NASA Kennedy Space Centers (KSCs) Center Planning and Development directorate, I have gained much experience and knowledge of what is expected of me in any work environment. Throughout my time at KSC, I have had a number of responsibilities and duties, many of which involved collaborating with other directorates in order to acquire guidance and information from other NASA experts, attending and participating in meetings, and also editing and providing input to a collective project. My goal in this paper is to summarize my experience at KSC by explaining my responsibilities in detail and the skills I am able to take away as a result that will further aid me in my career path for the future.

The cancer Warburg effect may be a testable example of the minimum entropy production rate principle

NASA Astrophysics Data System (ADS)

Marín, Dolores; Sabater, Bartolomé

2017-04-01

Cancer cells consume more glucose by glycolytic fermentation to lactate than by respiration, a characteristic known as the Warburg effect. In contrast with the 36 moles of ATP produced by respiration, fermentation produces two moles of ATP per mole of glucose consumed, which poses a puzzle with regard to the function of the Warburg effect. The production of free energy (ΔG), enthalpy (ΔH), and entropy (ΔS) per mole linearly varies with the fraction (x) of glucose consumed by fermentation that is frequently estimated around 0.9. Hence, calculation shows that, in respect to pure respiration, the predominant fermentative metabolism decreases around 10% the production of entropy per mole of glucose consumed in cancer cells. We hypothesize that increased fermentation could allow cancer cells to accomplish the Prigogine theorem of the trend to minimize the rate of production of entropy. According to the theorem, open cellular systems near the steady state could evolve to minimize the rates of entropy production that may be reached by modified replicating cells producing entropy at a low rate. Remarkably, at CO2 concentrations above 930 ppm, glucose respiration produces less entropy than fermentation, which suggests experimental tests to validate the hypothesis of minimization of the rate of entropy production through the Warburg effect.

The cancer Warburg effect may be a testable example of the minimum entropy production rate principle.

PubMed

Marín, Dolores; Sabater, Bartolomé

2017-04-28

Cancer cells consume more glucose by glycolytic fermentation to lactate than by respiration, a characteristic known as the Warburg effect. In contrast with the 36 moles of ATP produced by respiration, fermentation produces two moles of ATP per mole of glucose consumed, which poses a puzzle with regard to the function of the Warburg effect. The production of free energy (ΔG), enthalpy (ΔH), and entropy (ΔS) per mole linearly varies with the fraction (x) of glucose consumed by fermentation that is frequently estimated around 0.9. Hence, calculation shows that, in respect to pure respiration, the predominant fermentative metabolism decreases around 10% the production of entropy per mole of glucose consumed in cancer cells. We hypothesize that increased fermentation could allow cancer cells to accomplish the Prigogine theorem of the trend to minimize the rate of production of entropy. According to the theorem, open cellular systems near the steady state could evolve to minimize the rates of entropy production that may be reached by modified replicating cells producing entropy at a low rate. Remarkably, at CO 2 concentrations above 930 ppm, glucose respiration produces less entropy than fermentation, which suggests experimental tests to validate the hypothesis of minimization of the rate of entropy production through the Warburg effect.

Data Immersion for CCNY Undergraduate Summer Interns at the IEDA Geoinformatics Facility

NASA Astrophysics Data System (ADS)

Uribe, R.; Van Wert, T.; Alabi, T.

2016-12-01

National Science Foundation (NSF) funded programs that provide grants and resources to enhance undergraduate learning and provide a pathway to future career opportunities in the geosciences by increasing retention and broadening participation. In an increasingly digital world, geoinformatics and the importance of large data storage and accessibility is a rapidly expanding field in the geosciences. The NSF-funded Interdisciplinary Earth Data Alliance (IEDA) - City College of New York (CCNY) summer internship program aims to provide diverse undergraduates from CCNY with data processing experience within the IEDA facility at Columbia University's Lamont-Doherty Earth Observatory (LDEO). CCNY interns worked alongside IEDA mentors and were immersed in the day-to-day operations of the IEDA facility. Skills necessary to work with geoscience data were developed throughout the internship and participation with the broader cohort of Lamont summer interns was promoted. Summer lectures delivered by researchers at LDEO provided interns with cutting-edge geoscience content from experts across a wide range of fields in the Earth sciences. CCNY undergraduate interns undertook two data compilation projects. First, interns compiled LiDAR land elevation data to enhance the land-ocean base map used across IEDA map-based resources. For that, the interns downloaded and classified one- and three-meter resolution LiDAR topographic data from the USGS The National Mapfor the lower 48 states. Second, computer-derived regional and global seismic tomography models from the Incorporated Research Institutions for Seismology (IRIS) were compiled and processed for integration with GeoMapApp, a free mapping application developed at LDEO (www.geomapapp.org). Interns established a data processing workflow to extract tomographic depth slices from dozens of tomographic grids. Executing LINUX commands and shell scripts, the native format binary netCDF files were resampled and reformatted and compared to

The HK2 Dependent "Warburg Effect" and Mitochondrial Oxidative Phosphorylation in Cancer: Targets for Effective Therapy with 3-Bromopyruvate.

PubMed

Lis, Paweł; Dyląg, Mariusz; Niedźwiecka, Katarzyna; Ko, Young H; Pedersen, Peter L; Goffeau, Andre; Ułaszewski, Stanisław

2016-12-15

This review summarizes the current state of knowledge about the metabolism of cancer cells, especially with respect to the "Warburg" and "Crabtree" effects. This work also summarizes two key discoveries, one of which relates to hexokinase-2 (HK2), a major player in both the "Warburg effect" and cancer cell immortalization. The second discovery relates to the finding that cancer cells, unlike normal cells, derive as much as 60% of their ATP from glycolysis via the "Warburg effect", and the remaining 40% is derived from mitochondrial oxidative phosphorylation. Also described are selected anticancer agents which generally act as strong energy blockers inside cancer cells. Among them, much attention has focused on 3-bromopyruvate (3BP). This small alkylating compound targets both the "Warburg effect", i.e., elevated glycolysis even in the presence oxygen, as well as mitochondrial oxidative phosphorylation in cancer cells. Normal cells remain unharmed. 3BP rapidly kills cancer cells growing in tissue culture, eradicates tumors in animals, and prevents metastasis. In addition, properly formulated 3BP shows promise also as an effective anti-liver cancer agent in humans and is effective also toward cancers known as "multiple myeloma". Finally, 3BP has been shown to significantly extend the life of a human patient for which no other options were available. Thus, it can be stated that 3BP is a very promising new anti-cancer agent in the process of undergoing clinical development.

Metastasis suppressor KISS1 seems to reverse the Warburg effect by enhancing mitochondrial biogenesis

USDA-ARS?s Scientific Manuscript database

Cancer cells tend to utilize aerobic glycolysis even under normoxic conditions, commonly called the "Warburg Effect." Aerobic glycolysis often directly correlates with malignancy, but its purpose, if any, in metastasis remains unclear. When wild-type KISS1 metastasis suppressor is expressed, aerob...

Joint International Physics Summer School: Optics

NASA Astrophysics Data System (ADS)

Bondani, Maria; Allevi, Alessia; Soubusta, Jan; Haderka, Ondřej

2015-10-01

We report on the organization and realization of the Joint International Physics Summer School - Optics" devoted to High-School students. The idea of the School is to teach Physics through high-level experimental activities, suitably supported by introductory lectures and complemented by data analysis. The School is also open to the participation of a number of teachers, as an opportunity of refreshing their knowledge and increasing their experimental skills. Students and teachers are directly involved in the experimental activities. The aim of the activity is to stimulate students curiosity and interest and help them decide whether a future job career in Science could be suited for them. The School is organized in two weeks: the first in June-July in Como (Italy) at the Department of Science and High Technology and the second at the end of August in Olomouc (Czech Republic) at the Joint Laboratory of Optics. Two editions of the Summer School took place in 2013 and 2014 (overall 40 students and 3 teachers from Italy, 9 students from Czech Republic) and the third one will be in 2015. The first week of the School is devoted to introductory lectures (theoretical and experimental) to consolidate students' and teachers' knowledge of basic optics. The second week is devoted to several advanced experiments in linear, nonlinear, classical and quantum optics, performed in research laboratories. During the last day of the School, students are required to give a presentation of the results obtained during the experimental sessions.

Building expertise in glaciology through intense international summer schools

NASA Astrophysics Data System (ADS)

Hock, R.

2016-12-01

As the field of glaciology grows in response to recent rapid glacier changes and their potential socio-environmental consequences, the need for well-trained scientists possessing a high level expertise in physical glaciology has increased. Opportunities necessary to cultivate these efforts have not kept pace with the need for increased proficiency in this field. To our knowledge there is no academic degree in glaciology anywhere, but glaciology education, if offered at all, is generally restricted to one or a few individual classes. Glaciology graduate students tend to come from a wide range of background education and often pursue their degree at institutes without any glaciology classes. To cater to this demand we have organized four intense 11-day International Summer Schools in Glaciology which have provided an opportunity for a total of 119 students from around the world to obtain a comprehensive insight into a wide range of topics in glaciology and a more holistic view beyond the scope of their graduate thesis topic. The summer schools were held bi-annually (2010 - 2016) in the tiny village of McCarthy in central Alaska in the immediate vicinity of easily accessible glaciers. The unique setting facilitated close interaction among all participants. The courses included daily lectures, computational exercises, a poster-session and two glacier excursions. In addition, students worked in small teams on a glaciology computer project mentored by one of the 7-9 instructors from several US and foreign institutions, and presented their results in a `mini' student conference at the end of the course. All instructors were required to stay for the entire period. Thus the courses provided a valuable platform for international networking between students and instructors and among the students themselves, thereby fostering future collaborations. This was generally perceived as a major asset of our summer schools.

International Summer Student Seminar (3S), from Idea to Realization

NASA Astrophysics Data System (ADS)

Karpik, A. P.; Peled, A.; Musikhin, L. A.; Deren, L.; Seredovich, V. A.

2012-08-01

The article gives a spotlight on a three universities (Moscow State University of Geodesy and Cartography, Siberian State Academy of Geodesy, Wuhan University) and ISPRS' cooperation in organizing and holding summer student seminars for undergraduate, master, and PhD students of the universities specializing in photogrammetry, remote sensing, GIS, aerial and space cartography. Principles of topics of the seminar selection, lecture courses delivering and practical training as well as international joint team work on projects and their defence are described. The description of the basic stages of 3S implementation, and the goals of this sort of the international event is given.

Optical spectroscopic characteristics of lactate and mitochondrion as new biomarkers in cancer diagnosis: understanding Warburg effect

NASA Astrophysics Data System (ADS)

Liu, C.-H.; Ni, X. H.; Pu, Yang; Yang, Y. L.; Zhou, F.; Zuzolo, R.; Wang, W. B.; Masilamani, V.; Rizwan, A.; Alfano, R. R.

2012-01-01

Cancer cells display high rates of glycolysis even under normoxia and mostly under hypoxia. Warburg proposed this effect of altered metabolism in cells more than 80 years ago. It is considered as a hallmark of cancer. Optical spectroscopy can be used to explore this effect. Pathophysiological studies indicate that mitochondria of cancer cells are enlarged and increased in number. Warburg observed that cancer cells tend to convert most glucose to lactate regardless of the presence of oxygen. Previous observations show increased lactate in breast cancer lines. The focus of this study is to investigate the relative content changes of lactate and mitochondria in human cancerous and normal breast tissue samples using optical spectroscopic techniques. The optical spectra were obtained from 30 cancerous and 25 normal breast tissue samples and five model components (Tryptophan, fat, collagen, lactate and mitochondrion) using fluorescence, Stokes shift and Raman spectroscopy. The basic biochemical component analysis model (BBCA) and a set of algorithm were used to analyze the spectra. Our analyses of fluorescence spectra showed a 14 percent increase in lactate content and 2.5 times increase in mitochondria number in cancerous breast tissue as compared with normal tissue. Our findings indicate that optical spectroscopic techniques may be used to understand Warburg effect. Lactate and mitochondrion content changes in tumors examined using optical spectroscopy may be used as a prognostic molecular marker in clinic applications.

CHIP/Stub1 regulates the Warburg effect by promoting degradation of PKM2 in ovarian carcinoma.

PubMed

Shang, Y; He, J; Wang, Y; Feng, Q; Zhang, Y; Guo, J; Li, J; Li, S; Wang, Y; Yan, G; Ren, F; Shi, Y; Xu, J; Zeps, N; Zhai, Y; He, D; Chang, Z

2017-07-20

Tumor cells preferentially adopt aerobic glycolysis for their energy supply, a phenomenon known as the Warburg effect. It remains a matter of debate as to how the Warburg effect is regulated during tumor progression. Here, we show that CHIP (carboxyl terminus of Hsc70-interacting protein), a U-box E3 ligase, suppresses tumor progression in ovarian carcinomas by inhibiting aerobic glycolysis. While CHIP is downregulated in ovarian carcinoma, induced expression of CHIP results in significant inhibition of the tumor growth examined by in vitro and in vivo experiments. Reciprocally, depletion of CHIP leads to promotion of tumor growth. By a SiLAD proteomics analysis, we identified pyruvate kinase isoenzyme M2 (PKM2), a critical regulator of glycolysis in tumors, as a target that CHIP mediated for degradation. Accordingly, we show that CHIP regulates PKM2 protein stability and thereafter the energy metabolic processes. Depletion or knockout of CHIP increased the glycolytic products in both tumor and mouse embryonic fibroblast cells. Simultaneously, we observed that CHIP expression inversely correlated with PKM2 levels in human ovarian carcinomas. This study reveals a mechanism that the Warburg effect is regulated by CHIP through its function as an E3 ligase, which mediates the degradation of PKM2 during tumor progression. Our findings shed new light into understanding of ovarian carcinomas and may provide a new therapeutic strategy for ovarian cancer.

International Physics Summer Camp for High School Students

NASA Astrophysics Data System (ADS)

Pope, Damian T.; Korsunsky, B.

2006-12-01

Each year for the past three years, Perimeter Institute for Theoretical Physics in Waterloo, Ontario, Canada, has staged an annual physics summer camp for high school students worldwide. Known as the International Summer School for Young Physicists (ISSYP), it attracts students from all corners of the globe and this year had attendees from 15 countries and 5 continents. The camp is aimed at motivated students around the age of 16 and is a two-week immersion into the exciting world of cutting-edge physics today. It covers topics such as dark matter, superstring theory and quantum computers, and exposes attendees to some of the very latest research results. It includes lectures, tutorials, laboratory visits and small-group projects and, in addition to teaching new material, strives to give students a deeper appreciation of the true nature of science. Throughout, attendees have a great deal of interaction with the institute's scientists. This presentation will give an overview of the camp including the material taught within it, its impact on students and the goals of the program. More information about the camp can be found at: http://www.youngphysicists.ca

Warburg-like Glycolysis and Lactate Shuttle in Mouse Decidua during Early Pregnancy*

PubMed Central

Zuo, Ru-Juan; Gu, Xiao-Wei; Qi, Qian-Rong; Wang, Tong-Song; Zhao, Xu-Yu; Liu, Ji-Long; Yang, Zeng-Ming

2015-01-01

Decidualization is an essential process of maternal endometrial stromal cells to support pregnancy. Although it is known that enhanced glucose influx is critical for decidualization, the underlying mechanism in regulating glucose metabolism in decidua remains insufficiently understood. Here, we demonstrate that aerobic glycolysis-related genes and factors are all substantially induced during decidualization, indicating the existence of Warburg-like glycolysis in decidua. In vitro, progesterone activates hypoxia-inducible factor 1α (Hif1α) and c-Myc through Pi3k-Akt signaling pathway to maintain aerobic glycolysis in decidualizing cells. Knocking down of pyruvate kinase M2 (Pkm2) attenuates the induction of decidual marker gene. Decidual formation in vivo is also impaired by glycolysis inhibitor 3-bromopyruvate. Besides, lactate exporter monocarboxylate transporter 4 (Mct4) is induced in newly formed decidual cells, whereas lactate importer Mct1 and proliferation marker Ki-67 are complementarily located in the surrounding undifferentiated cells, which are supposed to consume lactate for proliferation. Hif1α activation is required for lactate-dependent proliferation of the undifferentiated cells. Inhibition of lactate flux leads to compromised decidualization and decelerated lactate-dependent proliferation. In summary, we reveal that Warburg-like glycolysis and local lactate shuttle are activated in decidua and play important roles for supporting early pregnancy. PMID:26178372

Intragenic DNA methylation and BORIS-mediated cancer-specific splicing contribute to the Warburg effect

PubMed Central

Singh, Smriti; Narayanan, Sathiya Pandi; Biswas, Kajal; Gupta, Amit; Ahuja, Neha; Yadav, Sandhya; Panday, Rajendra Kumar; Samaiya, Atul; Sharan, Shyam K.

2017-01-01

Aberrant alternative splicing and epigenetic changes are both associated with various cancers, but epigenetic regulation of alternative splicing in cancer is largely unknown. Here we report that the intragenic DNA methylation-mediated binding of Brother of Regulator of Imprinted Sites (BORIS) at the alternative exon of Pyruvate Kinase (PKM) is associated with cancer-specific splicing that promotes the Warburg effect and breast cancer progression. Interestingly, the inhibition of DNA methylation, BORIS depletion, or CRISPR/Cas9-mediated deletion of the BORIS binding site leads to a splicing switch from cancer-specific PKM2 to normal PKM1 isoform. This results in the reversal of the Warburg effect and the inhibition of breast cancer cell growth, which may serve as a useful approach to inhibit the growth of breast cancer cells. Importantly, our results show that in addition to PKM splicing, BORIS also regulates the alternative splicing of several genes in a DNA methylation-dependent manner. Our findings highlight the role of intragenic DNA methylation and DNA binding protein BORIS in cancer-specific splicing and its role in tumorigenesis. PMID:29073069

Mitochondrial pyruvate carrier function is negatively linked to Warburg phenotype in vitro and malignant features in esophageal squamous cell carcinomas

PubMed Central

Li, Yaqing; Li, Xiaoran; Kan, Quancheng; Zhang, Mingzhi; Li, Xiaoli; Xu, Ruiping; Wang, Junsheng; Yu, Dandan; Goscinski, Mariusz Adam; Wen, Jian-Guo; Nesland, Jahn M.; Suo, Zhenhe

2017-01-01

Aerobic glycolysis is one of the emerging hallmarks of cancer cells. In this study, we investigated the relationship between blocking mitochondrial pyruvate carrier (MPC) with MPC blocker UK5099 and the metabolic alteration as well as aggressive features of esophageal squamous carcinoma. It was found that blocking pyruvate transportation into mitochondria attenuated mitochondrial oxidative phosphorylation (OXPHOS) and triggered aerobic glycolysis, a feature of Warburg effect. In addition, the HIF-1α expression and ROS production were also activated upon UK5099 application. It was further revealed that the UK5099-treated cells became significantly more resistant to chemotherapy and radiotherapy, and the UK5099-treated tumor cells also exhibited stronger invasive capacity compared to the parental cells. In contrast to esophageal squamous epithelium cells, decreased MPC protein expression was observed in a series of 157 human squamous cell carcinomas, and low/negative MPC1 expression predicted an unfavorable clinical outcome. All these results together revealed the potential connection of altered MPC expression/activity with the Warburg metabolic reprogramming and tumor aggressiveness in cell lines and clinical samples. Collectively, our findings highlighted a therapeutic strategy targeting Warburg reprogramming of human esophageal squamous cell carcinomas. PMID:27911865

Norrie-Warburg syndrome: two novel mutations in patients with classical clinical phenotype.

PubMed

Gal, A; Veske, A; Jojart, G; Grammatico, B; Huber, B; Gu, S; del Porto, G; Senyi, K

1996-01-01

Norrie-Warburg syndrome (NWS) is a rare X-linked disorder characterized by blindness, which is invariable, deafness and mental disturbances, which are present occasionally. We describe here two novel mutations, a missense mutation (C126S) and a 1-base pair insertion (insT466/T467), together with a recurrent mutation (M1V), found in patients presenting with the classical clinical phenotype of NWS. All three mutations are likely to result in prominent structural changes of the norrin protein.

An international basic science and clinical research summer program for medical students.

PubMed

Ramjiawan, Bram; Pierce, Grant N; Anindo, Mohammad Iffat Kabir; Alkukhun, Abedalrazaq; Alshammari, Abdullah; Chamsi, Ahmad Talal; Abousaleh, Mohannad; Alkhani, Anas; Ganguly, Pallab K

2012-03-01

An important part of training the next generation of physicians is ensuring that they are exposed to the integral role that research plays in improving medical treatment. However, medical students often do not have sufficient time to be trained to carry out any projects in biomedical and clinical research. Many medical students also fail to understand and grasp translational research as an important concept today. In addition, since medical training is often an international affair whereby a medical student/resident/fellow will likely train in many different countries during his/her early training years, it is important to provide a learning environment whereby a young medical student experiences the unique challenges and value of an international educational experience. This article describes a program that bridges the gap between the basic and clinical research concepts in a unique international educational experience. After completing two semester curricula at Alfaisal University in Riyadh, Kingdom of Saudi Arabia, six medical students undertook a summer program at St. Boniface Hospital Research Centre, in Winnipeg, MB, Canada. The program lasted for 2 mo and addressed advanced training in basic science research topics in medicine such as cell isolation, functional assessment, and molecular techniques of analysis and manipulation as well as sessions on the conduct of clinical research trials, ethics, and intellectual property management. Programs such as these are essential to provide a base from which medical students can decide if research is an attractive career choice for them during their clinical practice in subsequent years. An innovative international summer research course for medical students is necessary to cater to the needs of the medical students in the 21st century.

AMP-activated Protein Kinase Stimulates Warburg-like Glycolysis and Activation of Satellite Cells during Muscle Regeneration*

PubMed Central

Fu, Xing; Zhu, Mei-Jun; Dodson, Mike V.; Du, Min

2015-01-01

Satellite cells are the major myogenic stem cells residing inside skeletal muscle and are indispensable for muscle regeneration. Satellite cells remain largely quiescent but are rapidly activated in response to muscle injury, and the derived myogenic cells then fuse to repair damaged muscle fibers or form new muscle fibers. However, mechanisms eliciting metabolic activation, an inseparable step for satellite cell activation following muscle injury, have not been defined. We found that a noncanonical Sonic Hedgehog (Shh) pathway is rapidly activated in response to muscle injury, which activates AMPK and induces a Warburg-like glycolysis in satellite cells. AMPKα1 is the dominant AMPKα isoform expressed in satellite cells, and AMPKα1 deficiency in satellite cells impairs their activation and myogenic differentiation during muscle regeneration. Drugs activating noncanonical Shh promote proliferation of satellite cells, which is abolished because of satellite cell-specific AMPKα1 knock-out. Taken together, AMPKα1 is a critical mediator linking noncanonical Shh pathway to Warburg-like glycolysis in satellite cells, which is required for satellite activation and muscle regeneration. PMID:26370082

PINK1 Is a Negative Regulator of Growth and the Warburg Effect in Glioblastoma.

PubMed

Agnihotri, Sameer; Golbourn, Brian; Huang, Xi; Remke, Marc; Younger, Susan; Cairns, Rob A; Chalil, Alan; Smith, Christian A; Krumholtz, Stacey-Lynn; Mackenzie, Danielle; Rakopoulos, Patricia; Ramaswamy, Vijay; Taccone, Michael S; Mischel, Paul S; Fuller, Gregory N; Hawkins, Cynthia; Stanford, William L; Taylor, Michael D; Zadeh, Gelareh; Rutka, James T

2016-08-15

Proliferating cancer cells are characterized by high rates of glycolysis, lactate production, and altered mitochondrial metabolism. This metabolic reprogramming provides important metabolites for proliferation of tumor cells, including glioblastoma. These biological processes, however, generate oxidative stress that must be balanced through detoxification of reactive oxygen species (ROS). Using an unbiased retroviral loss-of-function screen in nontransformed human astrocytes, we demonstrate that mitochondrial PTEN-induced kinase 1 (PINK1) is a regulator of the Warburg effect and negative regulator of glioblastoma growth. We report that loss of PINK1 contributes to the Warburg effect through ROS-dependent stabilization of hypoxia-inducible factor-1A and reduced pyruvate kinase muscle isozyme 2 activity, both key regulators of aerobic glycolysis. Mechanistically, PINK1 suppresses ROS and tumor growth through FOXO3a, a master regulator of oxidative stress and superoxide dismutase 2. These findings highlight the importance of PINK1 and ROS balance in normal and tumor cells. PINK1 loss was observed in a significant number of human brain tumors including glioblastoma (n > 900) and correlated with poor patient survival. PINK1 overexpression attenuates in vivo glioblastoma growth in orthotopic mouse xenograft models and a transgenic glioblastoma model in Drosophila Cancer Res; 76(16); 4708-19. ©2016 AACR. ©2016 American Association for Cancer Research.

Space transportation alternatives for large space programs - The International Space University summer session - 1992

NASA Technical Reports Server (NTRS)

Palaszewski, Bryan

1993-01-01

The issues discussed in this paper are the result of a 10-week study by the Space Solar Power Program design project members and the Space Transportation Group at the International Space University (ISU) summer session of 1992 to investigate new paradigms in space propulsion and how those paradigms might reduce the costs for large space programs. The program plan was to place a series of power satellites in Earth orbit. Several designs were studied where many kW, MW or GW of power would be transmitted to Earth or to other spacecraft in orbit. During the summer session, a space solar power system was also detailed and analyzed. At ISU, the focus of the study was to foster and develop some of the new paradigms that may eliminate the barriers to low cost for space exploration and exploitation. Many international and technical aspects of a large multinational program were studied. Environmental safety, space construction and maintenance, legal and policy issues of frequency allocation, technology transfer and control and many other areas were addressed.

Space transportation alternatives for large space programs: The International Space University Summer Session, 1992

NASA Technical Reports Server (NTRS)

Palaszewski, Bryan A.

1993-01-01

In 1992, the International Space University (ISU) held its Summer Session in Kitakyushu, Japan. This paper summarizes and expands upon some aspects of space solar power and space transportation that were considered during that session. The issues discussed in this paper are the result of a 10-week study by the Space Solar Power Program design project members and the Space Transportation Group to investigate new paradigms in space propulsion and how those paradigms might reduce the costs for large space programs. The program plan was to place a series of power satellites in Earth orbit. Several designs were studied where many kW, MW, or GW of power would be transmitted to Earth or to other spacecraft in orbit. During the summer session, a space solar power system was also detailed and analyzed. A high-cost space transportation program is potentially the most crippling barrier to such a space power program. At ISU, the focus of the study was to foster and develop some of the new paradigms that may eliminate the barriers to low cost for space exploration and exploitation. Many international and technical aspects of a large multinational program were studied. Environmental safety, space construction and maintenance, legal and policy issues of frequency allocation, technology transfer and control and many other areas were addressed. Over 120 students from 29 countries participated in this summer session. The results discussed in this paper, therefore, represent the efforts of many nations.

Under Summer Skies

ERIC Educational Resources Information Center

Texley, Juliana

2009-01-01

There's no better way to celebrate 2009, the International Year of Astronomy, than by curling up with a good book under summer skies. To every civilization, in every age, the skies inspired imagination and scientific inquiry. There's no better place to start your summer reading than under their influence. Here are a few selections identified by…

LncRNA IDH1-AS1 links the functions of c-Myc and HIF1α via IDH1 to regulate the Warburg effect

PubMed Central

Xiang, Shaoxun; Gu, Hao; Thorne, Rick F.; Zhang, Xu Dong; Wu, Mian

2018-01-01

The oncoprotein c-Myc plays an important role in regulating glycolysis under normoxia; yet, in cancer cells, HIF1α, which is essential for driving glycolysis under hypoxia, is often up-regulated even in the presence of oxygen. The relationship between these two major regulators of the Warburg effect remains to be fully defined. Here we demonstrate that regulation of a long noncoding RNA (lncRNA), named IDH1-AS1, enables c-Myc to collaborate with HIF1α in activating the Warburg effect under normoxia. c-Myc transcriptionally repressed IDH1-AS1, which, upon expression, promoted homodimerization of IDH1 and thus enhanced its enzymatic activity. This resulted in increased α-KG and decreased ROS production and subsequent HIF1α down-regulation, leading to attenuation of glycolysis. Hence, c-Myc repression of IDH1-AS1 promotes activation of the Warburg effect by HIF1α. As such, IDH1-AS1 overexpression inhibited cell proliferation, whereas silencing of IDH1-AS1 promoted cell proliferation and cancer xenograft growth. Restoring IDH1-AS1 expression may therefore represent a potential metabolic approach for cancer treatment. PMID:29378948

IN MEMORIUM: Second International Workshop & Summer School on Plasma Physics 2006

NASA Astrophysics Data System (ADS)

2007-04-01

Zdravko Neichev, a PhD student at University of Sofia and a member of the Local Organising Committee of the International Workshop and Summer School on Plasma Physics, died September 22, 2006 at the age of 27 in a tragic car accident. He was close to finishing his PhD thesis working thoroughly in the field of Plasma Physics. Being also an excellent programmer he produced a number of perfect programs for numerical modelling of the coaxial discharge properties. He was a smart, friendly person, always ready to help. His colleagues and friends will never forget his radiant smile. Zdravko Neichev

PREFACE: 4th International Workshop & Summer School on Plasma Physics 2010

NASA Astrophysics Data System (ADS)

2014-06-01

Fourth International Workshop & Summer School on Plasma Physics 2010 The Fourth International Workshop & Summer School on Plasma Physics (IWSSPP'10) is organized by St. Kliment Ohridsky University of Sofia, with co-organizers TCPA Foundation, Association EURATOM/IRNRE, The Union of the Physicists in Bulgaria, and the Bulgarian Academy of Sciences. It was held in Kiten, Bulgaria, at the Black Sea Coast, from July 5 to July 10, 2010. The scientific programme covers the topics Fusion Plasma and Materials; Plasma Modeling and Fundamentals; Plasma Sources, Diagnostics and Technology. As the previous issues of this scientific meeting (IWSSPP'05, J. Phys.: Conf. Series 44 (2006) and IWSSPP'06, J. Phys.: Conf. Series 63 (2007), IWSSPP'08, J. Phys.: Conf. Series 207 (2010), its aim was to stimulate the creation and support of a new generation of young scientists for further development of plasma physics fundamentals and applications, as well as to ensure an interdisciplinary exchange of views and initiate possible collaborations by bringing together scientists from various branches of plasma physics. This volume of Journal of Physics: Conference Series includes 34 papers (invited lectures, contributed talks and posters) devoted to various branches of plasma physics, among them fusion plasma and materials, dc and microwave discharge modelling, transport phenomena in gas discharge plasmas, plasma diagnostics, cross sections and rate constants of elementary processes, material processing, plasma-chemistry and technology. Some of them have been presented by internationally known and recognized specialists in their fields; others are MSc or PhD students' first steps in science. In both cases, we believe they will raise readers' interest. We would like to thank the members of both the International Advisory Committee and the Local Organizing Committee, the participants who sent their manuscripts and passed through the (sometimes heavy and troublesome) refereeing and editing

Tailoring Summer Research Experiences to Diverse Student Cohorts: Lessons Learned from Teaching Scientific Communication to Summer Interns

NASA Astrophysics Data System (ADS)

Batchelor, R. L.; Haacker, R.

2014-12-01

Scientific posters, presentations and papers are frequently assigned outputs for students participating in summer research experiences, yet previous exposure to any form of scientific communication is not a given. Providing training in scientific communication in some form is thus a necessity for many internship programs, especially those aimed towards academically younger students. In this presentation, we will share some of the experiences we've gained from teaching scientific communication workshops to summer interns who range from high school to graduate school. Building on the many years of experience learned through the Significant Opportunities in Atmospheric Research Science (SOARS) program, course material has been adapted and tailored to students participating in the National Center for Atmospheric Research High-School Internship Research Opportunity (HIRO, now the NCAR PreCollege Internship) and Research Experiences for Community College Students (RECCS, based with Colorado University's Cooperative Institute for Research in Environmental Science). SOARS also has experience supporting graduate students towards publication. Weekly communications workshops have served not only to provide necessary scientific skills, but also as a place to gather, reflect, discuss and build community. The unique opportunities and challenges in working with each of these groups will be discussed as part of the larger community discussion of how we can increase diversity in STEM through providing genuine research experiences to diverse and academically young students.

Revisiting the Crabtree/Warburg effect in a dynamic perspective: a fitness advantage against sugar-induced cell death

PubMed Central

de Alteriis, Elisabetta; Cartenì, Fabrizio; Parascandola, Palma; Serpa, Jacinta; Mazzoleni, Stefano

2018-01-01

ABSTRACT The mechanisms behind the Warburg effect in mammalian cells, as well as for the similar Crabtree effect in the yeast Saccharomyces cerevisiae, are still a matter of debate: why do cells shift from the energy-efficient respiration to the energy-inefficient fermentation at high sugar concentration? This review reports on the strong similarities of these phenomena in both cell types, discusses the current ideas, and provides a novel interpretation of their common functional mechanism in a dynamic perspective. This is achieved by analysing another phenomenon, the sugar-induced-cell-death (SICD) occurring in yeast at high sugar concentration, to highlight the link between ATP depletion and cell death. The integration between SICD and the dynamic functioning of the glycolytic process, suggests that the Crabtree/Warburg effect may be interpreted as the avoidance of ATP depletion in those conditions where glucose uptake is higher than the downstream processing capability of the second phase of glycolysis. It follows that the down-regulation of respiration is strategic for cell survival allowing the allocation of more resources to the fermentation pathway, thus maintaining the cell energetic homeostasis. PMID:29509056

Summer syncope syndrome.

PubMed

Huang, Jennifer Juxiang; Sharda, Natasha; Riaz, Irbaz Bin; Alpert, Joseph S

2014-08-01

Antihypertensive therapy is associated with significant relative risk reductions in the incidence of heart failure, myocardial infarction, and stroke. However, a common adverse reaction to antihypertensive therapy is orthostatic hypotension, dehydration, and syncope. We propose that continued use of antihypertensive medications at the same dosage during the dry summer months in patients living in the Sonoran desert leads to an increase in syncopal episodes. All hypertensive patients who were treated with medications and admitted with International Classification of Diseases, 9th Revision code diagnosis of syncope were included. They were defined as "cases" if they presented during the summer months (May to September 2012) and "controls" if they presented during the winter months (November 2012 to March 2013). The primary outcome measure was the presence of clinical dehydration. The statistical significance was determined using the 2-sided Fisher exact test. A total of 496 patients with an International Classification of Diseases, 9th Revision code diagnosis of syncope were screened, and 179 patients were included in the final analysis. In patients taking antihypertensive medications, there were a significantly higher number of cases of syncope secondary to dehydration or orthostatic hypotension during the summer months (45%) compared with the winter months (26%) (P = .01). The incidence of syncope was significantly higher in older patients (63%) compared with younger individuals (37%) during the summer months. The incidence of syncope increases during the summer months among people who reside in a dry desert climate and who are taking antihypertensive medications. On the basis of our findings, we describe an easily preventable condition that we define as the "Summer Syncope Syndrome." We recommend judicious reduction of antihypertensive therapy in patients residing in a hot and dry climate, particularly during the summer months. Copyright © 2014 Elsevier Inc. All

PPARs: Interference with Warburg' Effect and Clinical Anticancer Trials

PubMed Central

Vamecq, Joseph; Colet, Jean-Marie; Vanden Eynde, Jean Jacques; Briand, Gilbert; Porchet, Nicole; Rocchi, Stéphane

2012-01-01

The metabolic/cell signaling basis of Warburg's effect (“aerobic glycolysis”) and the general metabolic phenotype adopted by cancer cells are first reviewed. Several bypasses are adopted to provide a panoramic integrated view of tumoral metabolism, by attributing a central signaling role to hypoxia-induced factor (HIF-1) in the expression of aerobic glycolysis. The cancer metabolic phenotype also results from alterations of other routes involving ras, myc, p53, and Akt signaling and the propensity of cancer cells to develop signaling aberrances (notably aberrant surface receptor expression) which, when present, offer unique opportunities for therapeutic interventions. The rationale for various emerging strategies for cancer treatment is presented along with mechanisms by which PPAR ligands might interfere directly with tumoral metabolism and promote anticancer activity. Clinical trials using PPAR ligands are reviewed and followed by concluding remarks and perspectives for future studies. A therapeutic need to associate PPAR ligands with other anticancer agents is perhaps an important lesson to be learned from the results of the clinical trials conducted to date. PMID:22654896

Summer syncope syndrome redux.

PubMed

Huang, Jennifer Juxiang; Desai, Chirag; Singh, Nirmal; Sharda, Natasha; Fernandes, Aaron; Riaz, Irbaz Bin; Alpert, Joseph S

2015-10-01

While antihypertensive therapy is known to reduce the risk for heart failure, myocardial infarction, and stroke, it can often cause orthostatic hypotension and syncope, especially in the setting of polypharmacy and possibly, a hot and dry climate. The objective of the present study was to investigate whether the results of our prior study involving continued use of antihypertensive drugs at the same dosage in the summer as in the winter months for patients living in the Sonoran desert resulted in an increase in syncopal episodes during the hot summer months. All hypertensive patients who were treated with medications and admitted with International Classification of Diseases, 9th Revision code diagnosis of syncope were included. This is a 3-year retrospective chart review study. They were defined as "cases" if they presented during the summer months (May to September) and "controls" if they presented during the winter months (November to March). The primary outcome measure was the presence of clinical dehydration. The statistical significance was determined using the 2-sided Fisher's exact test. A total of 834 patients with an International Classification of Diseases, 9th Revision code diagnosis of syncope were screened: 477 in the summer months and 357 in the winter months. In patients taking antihypertensive medications, there was a significantly higher number of cases of syncope secondary to dehydration during the summer months (40.5%) compared with the winter months (29%) (P = .04). No difference was observed in the type of antihypertensive medication used and syncope rate. The number of antihypertensives used did not increase the cases of syncope in either summer or winter. An increased number of syncope events was observed in the summer months among people who reside in a dry desert climate and who are taking antihypertensive medications. The data confirm our earlier observations that demonstrated a greater number of cases of syncope among people who reside

Expression and phosphorylation of the AS160_v2 splice variant supports GLUT4 activation and the Warburg effect in multiple myeloma

PubMed Central

2013-01-01

Background Multiple myeloma (MM) is a fatal plasma cell malignancy exhibiting enhanced glucose consumption associated with an aerobic glycolytic phenotype (i.e., the Warburg effect). We have previously demonstrated that myeloma cells exhibit constitutive plasma membrane (PM) localization of GLUT4, consistent with the dependence of MM cells on this transporter for maintenance of glucose consumption rates, proliferative capacity, and viability. The purpose of this study was to investigate the molecular basis of constitutive GLUT4 plasma membrane localization in MM cells. Findings We have elucidated a novel mechanism through which myeloma cells achieve constitutive GLUT4 activation involving elevated expression of the Rab-GTPase activating protein AS160_v2 splice variant to promote the Warburg effect. AS160_v2-positive MM cell lines display constitutive Thr642 phosphorylation, known to be required for inactivation of AS160 Rab-GAP activity. Importantly, we show that enforced expression of AS160_v2 is required for GLUT4 PM translocation and activation in these select MM lines. Furthermore, we demonstrate that ectopic expression of a full-length, phospho-deficient AS160 mutant is sufficient to impair constitutive GLUT4 cell surface residence, which is characteristic of MM cells. Conclusions This is the first study to tie AS160 de-regulation to increased glucose consumption rates and the Warburg effect in cancer. Future studies investigating connections between the insulin/IGF-1/AS160_v2/GLUT4 axis and FDG-PET positivity in myeloma patients are warranted and could provide rationale for therapeutically targeting this pathway in MM patients with advanced disease. PMID:24280290

Combined targeting of PDK1 and EGFR triggers regression of glioblastoma by reversing the Warburg effect.

PubMed

Velpula, Kiran Kumar; Bhasin, Arnima; Asuthkar, Swapna; Tsung, Andrew J

2013-12-15

Glioblastoma multiforme is the most aggressive primary brain tumor in adults. Overexpression of the EGF receptor (EGFR) is recognized as a widespread oncogenic signature in glioblastoma multiforme, but the complexity of its contributions is not fully understood, nor the most effective ways to leverage anti-EGFR therapy in this setting. Hypoxia is known to drive the aggressive character of glioblastoma multiforme by promoting aerobic glycolysis rather than pyruvate oxidation carried out in mitochondria (OXPHOS), a phenomenon termed the Warburg effect, which is a general feature of oncogenesis. In this study, we report that hypoxia drives expression of the pyruvate dehydrogenase kinase (PDK1) and EGFR along with the hypoxia-inducing factor (HIF)-1α in human glioblastoma multiforme cells. PDK1 is a HIF-1-regulated gene and our findings indicated that hypoxia-induced PDK1 expression may promote EGFR activation, initiating a feed-forward loop that can sustain malignant progression. RNAi-mediated attenuation of PDK1 and EGFR lowered PDK1-EGFR activation and decreased HIF-1α expression, shifting the Warburg phenotype to OXPHOS and inhibiting glioblastoma multiforme growth and proliferation. In clinical specimens of glioblastoma multiforme, we found that immunohistochemical expression of PDK1, EGFR, and HIF-1α were elevated in glioblastoma multiforme specimens when compared with normal brain tissues. Collectively, our studies establish PDK1 as a key driver and candidate therapeutic target in glioblastoma multiforme. ©2013 AACR.

PREFACE: First International Workshop and Summer School on Plasma Physics

NASA Astrophysics Data System (ADS)

Benova, Evgenia; Zhelyazkov, Ivan; Atanassov, Vladimir

2006-07-01

The First International Workshop and Summer School on Plasma Physics (IWSSPP'05) organized by The Faculty of Physics, University of Sofia and the Foundation `Theoretical and Computational Physics and Astrophysics' was dedicated to the World Year of Physics 2005 and held in Kiten, Bulgaria, on the Black Sea Coast, from 8--12 June 2005. The aim of the workshop was to bring together scientists from various branches of plasma physics in order to ensure an interdisciplinary exchange of views and initiate possible collaborations. Another important task was to stimulate the creation and support of a new generation of young scientists for the further development of plasma physics fundamentals and applications. This volume of Journal of Physics: Conference Series includes 31 papers (invited lectures, contributed talks and posters) devoted to various branches of plasma physics, among them fusion research, kinetics and transport phenomena in gas discharge plasmas, MHD waves and instabilities in the solar atmosphere, dc and microwave discharge modelling, plasma diagnostics, cross sections and rate constants of elementary processes, material processing, plasma-chemistry and technology. Some of them have been presented by internationally known and recognized specialists in their fields; others are Masters or PhD students' first steps in science. In both cases, we believe they will stimulate readers' interest. We would like to thank the members of both the International Advisory Committee and the Local Organizing Committee. We greatly appreciate the financial support from the sponsors: the Department for Language Teaching and International Students at Sofia University, Dr Ivan Bogorov Publishing house, and Artgraph2 Publishing house. We would like to express our gratitude to the invited lecturers who were willing to pay the participation fee. In this way, in addition to the intellectual support they provided by means of their excellent lectures, they also supported the school

Light exposure at night disrupts host/cancer circadian regulatory dynamics: impact on the Warburg effect, lipid signaling and tumor growth prevention.

PubMed

Blask, David E; Dauchy, Robert T; Dauchy, Erin M; Mao, Lulu; Hill, Steven M; Greene, Michael W; Belancio, Victoria P; Sauer, Leonard A; Davidson, Leslie

2014-01-01

The central circadian clock within the suprachiasmatic nucleus (SCN) plays an important role in temporally organizing and coordinating many of the processes governing cancer cell proliferation and tumor growth in synchrony with the daily light/dark cycle which may contribute to endogenous cancer prevention. Bioenergetic substrates and molecular intermediates required for building tumor biomass each day are derived from both aerobic glycolysis (Warburg effect) and lipid metabolism. Using tissue-isolated human breast cancer xenografts grown in nude rats, we determined that circulating systemic factors in the host and the Warburg effect, linoleic acid uptake/metabolism and growth signaling activities in the tumor are dynamically regulated, coordinated and integrated within circadian time structure over a 24-hour light/dark cycle by SCN-driven nocturnal pineal production of the anticancer hormone melatonin. Dim light at night (LAN)-induced melatonin suppression disrupts this circadian-regulated host/cancer balance among several important cancer preventative signaling mechanisms, leading to hyperglycemia and hyperinsulinemia in the host and runaway aerobic glycolysis, lipid signaling and proliferative activity in the tumor.

The West African International Summer School for Young Astronomers

NASA Astrophysics Data System (ADS)

Strubbe, Linda; Okere, Bonaventure I.; Chibueze, James; Lepo, Kelly; White, Heidi; Zhang, Jielai; Izuikedinachi Okoh, Daniel; Reid, Michael; Hunter, Lisa; EKEOMA Opara, Fidelis

2015-08-01

In October 2013 over 75 undergraduate science students and teachers from Nigeria and Ghana attended the week-long West African International Summer School for Young Astronomers. We expect an even broader audience for the second offering of the school (to be held July 2015), supported by a grant from the OAD (TF1). These schools are organized by a collaboration of astronomers from the University of Toronto, the University of Nigeria, and the Nigerian National Space Research and Development Agency. We design and lead activities that teach astronomy content, promote students' self-identity as scientists, and encourage students to think critically and figure out solutions themselves. Equally important, we design intertwined evaluation strategies to assess the effectiveness of our programs. We will describe the broader context for developing astronomy in West Africa, the inquiry-based and active learning techniques used in the schools, and results from the qualitative and quantitative evaluations of student performance. We will also describe longer-term plans for future schools, supporting our alumni, and building a sustainable partnership between North American and Nigerian universities.

International Summer School on Astronomy and Space Science in Chile, first experience.

NASA Astrophysics Data System (ADS)

Stepanova, M.; Arellano-Baeza, A. A.

I International Summer School on Astronomy and Space Science took place in the Elqui Valley Chile January 15-29 2005 Eighty 12-17 year old students from Chile Russia Venezuela and Bulgaria obtained a valuable experience to work together with outstanding scientists from Chile and Russia and with Russian cosmonaut Alexander Balandine They also had opportunity to visit the main astronomical observatories and to participate in workshops dedicated to the telescope and satellite design and remote sensing This activity was supported by numerous institutions in Chile including the Ministry of Education the European Southern Observatory Chilean Space Agency Chilean Air Force Latin American Association of Space Geophysics the principal Chilean universities and the First Lady Mrs Luisa Duran

The Warburg effect version 2.0

PubMed Central

Menendez, Javier A.; Joven, Jorge; Cufí, Sílvia; Corominas-Faja, Bruna; Oliveras-Ferraros, Cristina; Cuyàs, Elisabet; Martin-Castillo, Begoña; López-Bonet, Eugeni; Alarcón, Tomás; Vazquez-Martin, Alejandro

2013-01-01

When fighting cancer, knowledge on metabolism has always been important. Today, it matters more than ever. The restricted cataloging of cancer genomes is quite unlikely to achieve the task of curing cancer, unless it is integrated into metabolic networks that respond to and influence the constantly evolving cancer stem cell (CSC) cellular states. Once the genomic era of carcinogenesis had pushed the 1920s Otto Warburg’s metabolic cancer hypothesis into obscurity for decades, the most recent studies begin to support a new developing paradigm, in which the molecular logic behind the conversion of non-CSCs into CSCs can be better understood in terms of the “metabolic facilitators” and “metabolic impediments” that operate as proximate openings and roadblocks, respectively, for the transcriptional events and signal transduction programs that ultimately orchestrate the intrinsic and/or microenvironmental paths to CSC cellular states. Here we propose that a profound understanding of how human carcinomas install a proper “Warburg effect version 2.0” allowing them to “run” the CSCs’ “software” programs should guide a new era of metabolo-genomic-personalized cancer medicine. By viewing metabolic reprogramming of CSCs as an essential characteristic that allows dynamic, multidimensional and evolving cancer populations to compete successfully for their expansion on the organism, we now argue that CSCs bioenergetics might be another cancer hallmark. A definitive understanding of metabolic reprogramming in CSCs may complement or to some extent replace, the 30-y-old paradigm of targeting oncogenes to treat human carcinomas, because it can be possible to metabolically create non-permissive or “hostile” metabotypes to prevent the occurrence of CSC cellular states with tumor- and metastasis-initiating capacity. PMID:23549172

Heterogeneity and proliferation of invasive cancer subclones in game theory models of the Warburg effect.

PubMed

Archetti, M

2015-04-01

The Warburg effect, a switch from aerobic energy production to anaerobic glycolysis, promotes tumour proliferation and motility by inducing acidification of the tumour microenvironment. Therapies that reduce acidity could impair tumour growth and invasiveness. I analysed the dynamics of cell proliferation and of resistance to therapies that target acidity, in a population of cells, under the Warburg effect. The dynamics of mutant cells with increased glycolysis and motility has been assessed in a multi-player game with collective interactions in the framework of evolutionary game theory. Perturbations of the level of acidity in the microenvironment have been used to simulate the effect of therapies that target glycolysis. The non-linear effects of glycolysis induce frequency-dependent clonal selection leading to coexistence of glycolytic and non-glycolytic cells within a tumour. Mutants with increased motility can invade such a polymorphic population and spread within the tumour. While reducing acidity may produce a sudden reduction in tumour cell proliferation, frequency-dependent selection enables it to adapt to the new conditions and can enable the tumour to restore its original levels of growth and invasiveness. The acidity produced by glycolysis acts as a non-linear public good that leads to coexistence of cells with high and low glycolysis within the tumour. Such a heterogeneous population can easily adapt to changes in acidity. Therapies that target acidity can only be effective in the long term if the cost of glycolysis is high, that is, under non-limiting oxygen concentrations. Their efficacy, therefore, is reduced when combined with therapies that impair angiogenesis. © 2015 The Authors Cell Proliferation Published by John Wiley & Sons Ltd.

Understanding the Warburg effect: the metabolic requirements of cell proliferation.

PubMed

Vander Heiden, Matthew G; Cantley, Lewis C; Thompson, Craig B

2009-05-22

In contrast to normal differentiated cells, which rely primarily on mitochondrial oxidative phosphorylation to generate the energy needed for cellular processes, most cancer cells instead rely on aerobic glycolysis, a phenomenon termed "the Warburg effect." Aerobic glycolysis is an inefficient way to generate adenosine 5'-triphosphate (ATP), however, and the advantage it confers to cancer cells has been unclear. Here we propose that the metabolism of cancer cells, and indeed all proliferating cells, is adapted to facilitate the uptake and incorporation of nutrients into the biomass (e.g., nucleotides, amino acids, and lipids) needed to produce a new cell. Supporting this idea are recent studies showing that (i) several signaling pathways implicated in cell proliferation also regulate metabolic pathways that incorporate nutrients into biomass; and that (ii) certain cancer-associated mutations enable cancer cells to acquire and metabolize nutrients in a manner conducive to proliferation rather than efficient ATP production. A better understanding of the mechanistic links between cellular metabolism and growth control may ultimately lead to better treatments for human cancer.

Flux balance analysis predicts Warburg-like effects of mouse hepatocyte deficient in miR-122a

PubMed Central

Wu, Hsuan-Hui; Chen, Meng-Chun; Liu, Wen-Huan; Wu, Wu-Hsiung; Chang, Peter Mu-Hsin; Huang, Chi-Ying F.; Tsou, Ann-Ping; Shiao, Ming-Shi

2017-01-01

The liver is a vital organ involving in various major metabolic functions in human body. MicroRNA-122 (miR-122) plays an important role in the regulation of liver metabolism, but its intrinsic physiological functions require further clarification. This study integrated the genome-scale metabolic model of hepatocytes and mouse experimental data with germline deletion of Mir122a (Mir122a–/–) to infer Warburg-like effects. Elevated expression of MiR-122a target genes in Mir122a–/–mice, especially those encoding for metabolic enzymes, was applied to analyze the flux distributions of the genome-scale metabolic model in normal and deficient states. By definition of the similarity ratio, we compared the flux fold change of the genome-scale metabolic model computational results and metabolomic profiling data measured through a liquid-chromatography with mass spectrometer, respectively, for hepatocytes of 2-month-old mice in normal and deficient states. The Ddc gene demonstrated the highest similarity ratio of 95% to the biological hypothesis of the Warburg effect, and similarity of 75% to the experimental observation. We also used 2, 6, and 11 months of mir-122 knockout mice liver cell to examined the expression pattern of DDC in the knockout mice livers to show upregulated profiles of DDC from the data. Furthermore, through a bioinformatics (LINCS program) prediction, BTK inhibitors and withaferin A could downregulate DDC expression, suggesting that such drugs could potentially alter the early events of metabolomics of liver cancer cells. PMID:28686599

Internally Generated and Externally Forced Multidecadal Oceanic Modes and their Influence on the Summer Rainfall over East Asia

NASA Astrophysics Data System (ADS)

Si, D.; Hu, A.

2017-12-01

The interdecadal oceanic variabilities can be generated from both internal and external processes, and these variabilities can significantly modulate our climate on global and regional scale, such as the warming slowdown in the early 21st century, and the rainfall in East Asia. By analyzing simulations from a unique Community Earth System Model (CESM) Large Ensemble (CESM_LE) project, we show that the Interdecadal Pacific Oscillation (IPO) is primarily an internally generated oceanic variability, while the Atlantic Multidecadal Oscillation (AMO) may be an oceanic variability generated by internal oceanic processes and modulated by external forcings in the 20th century. Although the observed relationship between IPO and the Yangtze-Huaihe River valley (YHRV) summer rainfall in China is well simulated in both the preindustrial control and 20th century ensemble, none of the 20th century ensemble members can reproduce the observed time evolution of both IPO and YHRV due to the unpredictable nature of IPO on multidecade timescale. On the other hand, although CESM_LE cannot reproduce the observed relationship between AMO and Huanghe River valley (HRV) summer rainfall of China in the preindustrial control simulation, this relationship in the 20th century simulations is well reproduced, and the chance to reproduce the observed time evolution of both AMO and HRV rainfall is about 30%, indicating the important role of the interaction between the internal processes and the external forcing to realistically simulate the AMO and HRV rainfall.

PREFACE: Second International Workshop & Summer School on Plasma Physics 2006

NASA Astrophysics Data System (ADS)

Benova, Evgeniya; Atanassov, Vladimir

2007-04-01

The Second International Workshop & Summer School on Plasma Physics (IWSSPP'06) organized by St. Kliment Ohridsky University of Sofia, The Union of the Physicists in Bulgaria, the Bulgarian Academy of Sciences and the Bulgarian Nuclear Society, was held in Kiten, Bulgaria, on the Black Sea Coast, from 3-9 July 2006. As with the first of these scientific meetings (IWSSPP'05 Journal of Physics: Conference Series 44 (2006)), its aim was to stimulate the creation and support of a new generation of young scientists for further development of plasma physics fundamentals and applications, as well as to ensure an interdisciplinary exchange of views and initiate possible collaborations by bringing together scientists from various branches of plasma physics. This volume of Journal of Physics: Conference Series includes 33 papers (invited lectures, contributed talks and posters) devoted to various branches of plasma physics, among them fusion plasma research, dc and microwave discharge modelling, transport phenomena in gas discharge plasmas, plasma diagnostics, cross sections and rate constants of elementary processes, material processing, plasma-chemistry and technology. Some of these papers were presented by internationally known and recognized specialists in their fields; others are MSc or PhD students' first steps in science. In both cases, we believe they will raise readers' interest. We would like to thank the members of both the International Advisory Committee and the Local Organizing Committee, the participants who sent their manuscripts and passed through the (sometimes heavy and troublesome) refereeing and editing procedure and our referees for their patience and considerable effort to improve the manuscripts. We greatly appreciate the financial support from the sponsors: the Department for Language Teaching and International Students at the University of Sofia and Natsionalna Elektricheska Kompania EAD. We would like to express our gratitude to the invited

Summer Research Internships at Biosphere 2 Center

NASA Technical Reports Server (NTRS)

Broecker, Wallace S.; Colodner, Debra; Griffin, Kevin

1997-01-01

Through the support of NASA's Mission to Planet Earth, Biosphere 2 Center hosted 11 research interns for 6 to 8 weeks each during the summer of 1997. In addition, we were able to offer scholarships to 14 students for Columbia University summer field courses. These two types of programs engaged students in much of the range of activity of practicing Earth Scientists, with an emphasis on the collection and analysis of data in both the field and the laboratory. Research interns and students in the field courses also played an important part in the design and evolution of their research projects. In addition to laboratory and field research, students participated in weekly research seminars by resident and visiting scientists. Research interns were exposed to the geology and ecology of the region via short field trips to the Arizona Sonora Desert Museum, Mount Lemmon, Aravaipa Canyon and the Gulf of California, while field course students were exposed to laboratory-based research via intern-led hands-on demonstrations of their work. All students made oral and written presentations of their work during the summer, and two of the research interns have applied to present their results at the National Conference on Undergraduate Research in Maryland in April, 1998.

Microenvironmental cooperation promotes early spread and bistability of a Warburg-like phenotype.

PubMed

Fernandez-de-Cossio-Diaz, Jorge; De Martino, Andrea; Mulet, Roberto

2017-06-08

We introduce an in silico model for the initial spread of an aberrant phenotype with Warburg-like overflow metabolism within a healthy homeostatic tissue in contact with a nutrient reservoir (the blood), aimed at characterizing the role of the microenvironment for aberrant growth. Accounting for cellular metabolic activity, competition for nutrients, spatial diffusion and their feedbacks on aberrant replication and death rates, we obtain a phase portrait where distinct asymptotic whole-tissue states are found upon varying the tissue-blood turnover rate and the level of blood-borne primary nutrient. Over a broad range of parameters, the spreading dynamics is bistable as random fluctuations can impact the final state of the tissue. Such a behaviour turns out to be linked to the re-cycling of overflow products by non-aberrant cells. Quantitative insight on the overall emerging picture is provided by a spatially homogeneous version of the model.

FOREWORD: International Summer School for Advanced Studies 'Dynamics of open nuclear systems' (PREDEAL12)

NASA Astrophysics Data System (ADS)

Delion, D. S.; Zamfir, N. V.; Raduta, A. R.; Gulminelli, F.

2013-02-01

This proceedings volume contains the invited lectures and contributions presented at the International Summer School on Nuclear Physics held at Trei Brazi, a summer resort of the Bioterra University, near the city of Predeal, Romania, on 9-20 July 2012. The long tradition of International Summer Schools on Nuclear Physics in Romania dates as far back as 1964, with the event being scheduled every two years. During this period of almost 50 years, many outstanding nuclear scientists have lectured on various topics related to nuclear physics and particle physics. This year we celebrate the 80th birthday of Aureliu Sandulescu, one of the founders of the Romanian school of theoretical nuclear physics. He was Serban Titeica's PhD student, one of Werner Heisenberg's PhD students, and he organized the first edition of this event. Aureliu Sandulescu's major contributions to the field of theoretical nuclear physics are related in particular to the prediction of cluster radioactivity, the physics of open quantum systems and the innovative technique of detecting superheavy nuclei using the double magic projectile 48Ca (Calcium), nowadays a widely used method at the JINR—Dubna and GSI—Darmstadt laboratories. The title of the event, 'Dynamics of Open Nuclear Systems', is in recognition of Aureliu Sandulescu's great personality. The lectures were attended by Romanian and foreign Master and PhD students and young researchers in nuclear physics. About 25 reputable professors and researchers in nuclear physics delivered lectures during this period. According to a well-established tradition, an interval of two hours was allotted for each lecture (including discussions). Therefore we kept a balance between the school and conference format. Two lectures were held during the morning and afternoon sessions. After lecture sessions, three or four oral contributions were given by young scientists. This was a good opportunity for them to present the results of their research in front of

Summer Study Abroad.

ERIC Educational Resources Information Center

Cohen, Gail A., Ed.

This catalog describes summer study abroad programs around the world for students of college age and up. The included information was obtained from surveys conducted by the Institute of International Education in September 1978. The catalog contains programs of interest to the pre-college student who wants to improve his language skills before…

Strategies for the Internal Development of Summer Sessions.

ERIC Educational Resources Information Center

Seagren, Alan T.; And Others

Organizational matters and strategies useful in developing more effective collegiate summer sessions are discussed, and examples of some productive strategies at the University of Nebraska-Lincoln are reported. Four elements of organizational structure in higher education considered are organizational environment, mission and goals, governance…

The 2017 CALDAR Summer Institute and International Conference Promoting Global Health-Precision Research in Substance Abuse, HIV, and Care.

PubMed

Hser, Yih-Ing; Li, Ming D; Grella, Christine; Brecht, Lynn; Chen, Zhiwei; Chang, Sulie L; Chang, Linda; Normand, Jacques; Tai, Betty

2017-06-01

The 2017 CALDAR Summer Institute on Longituidnal Research and International Conference Series to Promote Global Health will take place in Los Angeles Universal City, CA, USA from August 15 to August 17, 2017. The conference will present a selection of the lastest and most current reseach in the areas of addiction, HIV, and related treatment.

A tripolar pattern as an internal mode of the East Asian summer monsoon

NASA Astrophysics Data System (ADS)

Hirota, Nagio; Takahashi, Masaaki

2012-11-01

A tripolar anomaly pattern with centers located around the Philippines, China/Japan, and East Siberia dominantly appears in climate variations of the East Asian summer monsoon. In this study, we extracted this pattern as the first mode of a singular value decomposition (SVD1) over East Asia. The squared covariance fraction of SVD1 was 59 %, indicating that this pattern can be considered a dominant pattern of climate variations. Moreover, the results of numerical experiments suggested that the structure is also a dominant pattern of linear responses, even if external forcing is distributed homogeneously over the Northern Hemisphere. Thus, the tripolar pattern can be considered an internal mode that is characterized by the internal atmospheric processes. In this pattern, the moist processes strengthen the circulation anomalies, the dynamical energy conversion supplies energy to the anomalies, and the Rossby waves propagate northward in the lower troposphere and southeastward in the upper troposphere. These processes are favorable for the pattern to have large amplitude and to influence a large area.

NMR ({sup 1}H and {sup 13}C) based signatures of abnormal choline metabolism in oral squamous cell carcinoma with no prominent Warburg effect

DOE Office of Scientific and Technical Information (OSTI.GOV)

Bag, Swarnendu, E-mail: Swarna.bag@gmail.com; Banerjee, Deb Ranjan, E-mail: debranjan2@gmail.com; Basak, Amit, E-mail: absk@chem.iitkgp.ernet.in

At functional levels, besides genes and proteins, changes in metabolome profiles are instructive for a biological system in health and disease including malignancy. It is understood that metabolomic alterations in association with proteomic and transcriptomic aberrations are very fundamental to unravel malignant micro-ambient criticality and oral cancer is no exception. Hence deciphering intricate dimensions of oral cancer metabolism may be contributory both for integrated appreciation of its pathogenesis and to identify any critical but yet unexplored dimension of this malignancy with high mortality rate. Although several methods do exist, NMR provides higher analytical precision in identification of cancer metabolomic signature.more » Present study explored abnormal signatures in choline metabolism in oral squamous cell carcinoma (OSCC) using {sup 1}H and {sup 13}C NMR analysis of serum. It has demonstrated down-regulation of choline with concomitant up-regulation of its break-down product in the form of trimethylamine N-oxide in OSCC compared to normal counterpart. Further, no significant change in lactate profile in OSCC possibly indicated that well-known Warburg effect was not a prominent phenomenon in such malignancy. Amongst other important metabolites, malonate has shown up-regulation but D-glucose, saturated fatty acids, acetate and threonine did not show any significant change. Analyzing these metabolomic findings present study proposed trimethyl amine N-oxide and malonate as important metabolic signature for oral cancer with no prominent Warburg effect. - Highlights: • NMR ({sup 1}H and {sup 13}C) study of Oral Squamous cell Carcinoma Serum. • Abnormal Choline metabolomic signatures. • Up-regulation of Trimethylamine N-oxide. • Unchanged lactate profile indicates no prominent Warburg effect. • Proposed alternative glucose metabolism path through up-regulation of malonate.« less

Developing High School Geoscientists through Summer Internships

NASA Astrophysics Data System (ADS)

Saltzman, J.

2012-12-01

High school students in the San Francisco Bay Area have the opportunity to contribute to Earth sciences research during the summer at Stanford University. The School of Earth Sciences hosts about 25 high school students each summer to support ongoing research, through more than just washing glassware. To increase diversity in the geosciences, we select students from diverse backgrounds through an application process which lessens the burden on busy faculty. The students work for 15-20 hours per week under the supervision of graduate students or postdoctoral fellows. The supervisors come to value the interns for a few reasons: not only are they getting some extra help with their research, but they are getting teaching experience in an informal but powerful way and supervising the interns' work over the summer. Another key part of the internship is bringing all of the interns together regularly. Whether it is for career talks, lab tours or field trip, high school students find kindred spirits in the group. Another important reason for weekly gatherings is to introduce the students to the wide field of Earth sciences and the different approaches and paths that scientists take. The summer ends with a culminating event where interns make short informal presentations about their research which give them an opportunity to articulate the big questions they have been helping to answer. Some interns are also invited to present a poster in a session for high school students at the Fall AGU meeting. These experiences of working in the laboratory and communicating about the research are part of the world of Earth sciences that are absent for most youth. The high school internships foster good will between Stanford and the local communities, help develop a more Earth and environmentally knowledgeable public and may have a long-term affect on diversifying the geosciences by exposing more young people to these fields.

Vienna international summer school on experimental and clinical oncology for medical students: an Austrian cancer education project.

PubMed

Fromm-Haidenberger, Sabine; Pohl, Gudrun; Widder, Joachim; Kren, Gerhard; Fitzal, Florian; Bartsch, Rupert; de Vries, Jakob; Zielinski, Christoph; Pötter, Richard

2010-03-01

The "International Summer School on Experimental and Clinical Oncology for Medical Students" is organised at the Medical University of Vienna to teach a multidisciplinary approach to oncology to medical students in the final phase of their studies. The program includes biology, diagnosis, clinical and psycho-oncology. Lectures are given by medical, radiation and surgical oncologists. Teaching includes case reports, poster presentations and role-play. As part of the organising committee, Austrian students organise a social program. Since 1999, six courses have been held (147 students from 19 countries). Students recorded high satisfaction with organisation, scientific content and topic range. Case presentations, poster presentations and role-play were very useful. Early criticism that the program was too intense (long lectures and little interaction) has been answered. The summer school has a high degree of acceptance and is a very useful tool to teach medical students about oncology and approaching a cancer patient.

Summer 2014 Pathways Report

NASA Technical Reports Server (NTRS)

Hand, Zachary

2014-01-01

Over the summer I had the exciting opportunity to work for NASA at the Kennedy Space Center as a Mission Assurance Engineering intern. When I was offered a position in mission assurance for the Safety and Mission Assurance directorate's Launch Services Division, I didn't really know what I would be doing, but I knew it would be an excellent opportunity to learn and grow professionally. In this report I will provide some background information on the Launch Services Division, as well as detail my duties and accomplishments during my time as an intern. Additionally, I will relate the significance of my work experience to my current academic work and future career goals. This report contains background information on Mission Assurance Engineering, a description of my duties and accomplishments over the summer of 2014, and relates the significance of my work experience to my school work and future career goals. It is a required document for the Pathways program.

Occupational health crossing borders - part 1: concept, teaching methods, and user evaluation of the first international summer school in Munich, Germany.

PubMed

Radon, Katja; Ehrenstein, Vera; Bigaignon-Cantineau, Janine; Vellore, Arun Dev; Fingerhut, Marilyn; Nowak, Dennis

2009-10-01

Occupational health and safety (OHS) is relevant for occupational health professionals (OHP) throughout the world. However, training opportunities are often limited and exchange between OHP from industrialized and developing countries is sparse. We aimed to contribute to the international exchange of OHP through a 2-week summer school program. Twenty-three OHP from 11 countries participated. Teaching methods included interactive lectures, participants' presentations, case-based e-learning, enterprise visits, and hands-on sessions. After completion, participants evaluated the course. OHS systems of 18 different countries were presented using the same set of clinical cases as a starting point. Opportunities and challenges in the different OHS systems were considered. On median, participants rated the course as excellent and totally agreed that it will help them in their daily work. An international summer school teaching basic aspects of different OHS systems is a useful tool for training and exchange at the global level. Copyright 2009 Wiley-Liss, Inc.

Support for International Space University?s (ISU) 2003 Summer Session Program and the Theme Day on ?Living and Working in Space?

NASA Technical Reports Server (NTRS)

Finarelli, Margaret G.

2004-01-01

The 2003 Summer Session Program of the International Space University (ISU) was conducted at the ISU Central Campus in Strasbourg, France, July 5-September 6, 2003. Attending the Summer Session were 114 students from 27 countries including the US. The International Space University (ISU) offers its students a unique and comprehensive educational package covering all disciplines related to space programs and enterprises - space science, space engineering, systems engineering, space policy and law, business and management, and space and society. By providing international graduate students and young space professionals both an intensive interdisciplinary curriculum and also the opportunity to solve complex problems together in an intercultural environment, ISU is preparing the future leaders of the emerging global space community. Since its founding in 1988, ISU has graduated more than 2200 students from 87 countries. Together with hundreds of ISU faculty and lecturers from around the world, ISU alumni comprise an extremely effective network of space professionals and leaders that actively facilitates individual career growth, professional activities and international space cooperation. ISU's interdisciplinary Student Theme Days and Student Workshops are intended to have great educational value for the participants. Along with the interdisciplinary Core Lectures, they apprise the students of state-of-the-art activities, programs and policies in spacefaring nations. They also provide ISU students the opportunity to meet world experts in space-related subjects.

Summer Research Internships at Biosphere 2 Center

NASA Technical Reports Server (NTRS)

1998-01-01

Through the support of NASA's Mission to Planet Earth, Biosphere 2 Center hosted 10 research interns for a 10 week period during the summer of 1998. In addition, we were able to offer scholarships to 10 students for Columbia University summer field courses. Students participating in these programs were involved in numerous earth systems activities, collecting data in the field and conducting analyses in the laboratory. Students enrolled in the field program were expected to design independent research projects as part of their coursework. In addition to laboratory and field research, students participated in weekly research seminars by resident and visiting scientists. Field school students were involved in field trips exposing them to the geology and ecology of the region including Arizona Sonora Desert Museum, Mount Lemmon, Aravaipa Canyon and the Gulf of California. Interns participated in laboratory-based research. All students were expected to complete oral and written presentations of their work during the summer.

Ginsenoside 20(S)-Rg3 Inhibits the Warburg Effect Via Modulating DNMT3A/ MiR-532-3p/HK2 Pathway in Ovarian Cancer Cells.

PubMed

Zhou, Yuanyuan; Zheng, Xia; Lu, Jiaojiao; Chen, Wei; Li, Xu; Zhao, Le

2018-01-01

The Warburg effect is one of the main energy metabolism features supporting cancer cell growth. 20(S)-Rg3 exerts anti-tumor effect on ovarian cancer partly by inhibiting the Warburg effect. microRNAs are important regulators of the Warburg effect. However, the microRNA regulatory network mediating the anti-Warburg effect of 20(S)-Rg3 was largely unknown. microRNA deep sequencing was performed to identify the 20(S)-Rg3-influenced microRNAs in SKOV3 ovarian cancer cells. miR-532-3p was overexpressed by mimic532-3p transfection in SKOV3 and A2780 cells or inhibited by inhibitor532-3p transfection in 20(S)-Rg3-treated cells to examine the changes in HK2 and PKM2 expression, glucose consumption, lactate production and cell growth. Dual-luciferase reporter assay was conducted to verify the direct binding of miR-532-3p to HK2. The methylation status in the promoter region of pre-miR-532-3p gene was examined by methylation-specific PCR. Expression changes of key molecules controlling DNA methylation including DNMT1, DNMT3A, DNMT3B, and TET1-3 were examined in 20(S)-Rg3-treated cells. DNMT3A was overexpressed in 20(S)-Rg3-treated cells to examine its influence on miR-532-3p level, HK2 and PKM2 expression, glucose consumption and lactate production. Deep sequencing results showed that 11 microRNAs were increased and 9 microRNAs were decreased by 20(S)-Rg3 in SKOV3 cells, which were verified by qPCR. More than 2-fold increase of miR-532-3p was found in 20(S)-Rg3-treated SKOV3 cells. Forced expression of miR-532-3p reduced HK2 and PKM2 expression, glucose consumption and lactate production in SKOV3 and A2780 ovarian cancer cells. Inhibition of miR-532-3p antagonized the suppressive effect of 20(S)-Rg3 on HK2 and PKM2 expression, glucose consumption and lactate production in ovarian cancer cells. Dual-luciferase reporter assay showed that miR-532-3p directly suppressed HK2 rather than PKM2. miR-532-3p level was controlled by the methylation in the promoter region of its host

Hexokinase-2 bound to mitochondria: Cancer's stygian link to the “Warburg effect” and a pivotal target for effective therapy☆

PubMed Central

Mathupala, Saroj P.; Ko, Young H.; Pedersen, Peter L.

2009-01-01

The most common metabolic hallmark of malignant tumors, i.e., the “Warburg effect” is their propensity to metabolize glucose to lactic acid at a high rate even in the presence of oxygen. The pivotal player in this frequent cancer phenotype is mitochondrial-bound hexokinase [Bustamante E, Pedersen PL. High aerobic glycolysis of rat hepatoma cells in culture: role of mitochondrial hexokinase. Proc Natl Acad Sci USA 1977;74(9):3735−9; Bustamante E, Morris HP, Pedersen PL. Energy metabolism of tumor cells. Requirement for a form of hexokinase with a propensity for mitochondrial binding. J Biol Chem 1981;256(16):8699−704]. Now, in clinics worldwide this prominent phenotype forms the basis of one of the most common detection systems for cancer, i.e., positron emission tomography (PET). Significantly, HK-2 is the major bound hexokinase isoform expressed in cancers that exhibit a “Warburg effect”. This includes most cancers that metastasize and kill their human host. By stationing itself on the outer mitochondrial membrane, HK-2 also helps immortalize cancer cells, escapes product inhibition and gains preferential access to newly synthesized ATP for phosphorylating glucose. The latter event traps this essential nutrient inside the tumor cells as glucose-6-P, some of which is funneled off to serve as carbon precursors to help promote the production of new cancer cells while much is converted to lactic acid that exits the cells. The resultant acidity likely wards off an immune response while preparing surrounding tissues for invasion. With the re-emergence and acceptance of both the “Warburg effect” as a prominent phenotype of most clinical cancers, and “metabolic targeting” as a rational therapeutic strategy, a number of laboratories are focusing on metabolite entry or exit steps. One remarkable success story [Ko YH, Smith BL, Wang Y, Pomper MG, Rini DA, Torbenson MS, et al. Advanced cancers: eradication in all cases using 3-bromopyruvate therapy to

Founder Fukutin mutation causes Walker-Warburg syndrome in four Ashkenazi Jewish families†

PubMed Central

Chang, Wendy; Winder, Thomas L.; LeDuc, Charles A.; Simpson, Lynn L.; Millar, William S.; Dungan, Jeffrey; Ginsberg, Norman; Plaga, Stacey; Moore, Steven A.; Chung, Wendy K.

2009-01-01

Objective Walker-Warburg syndrome (WWS) is a genetically heterogeneous congenital muscular dystrophy caused by abnormal glycosylation of α-dystroglycan (α-DG) that is associated with brain malformations and eye anomalies. The Fukutin (FKTN) gene, which causes autosomal recessively inherited WWS is most often associated with Fukuyama congenital muscular dystrophy in Japan. We describe the clinical features of four nonconsanguinous Ashkenazi Jewish families with WWS and identify the underlying genetic basis for WWS. Method We screened for mutations in POMGnT1, POMT1, POMT2, and FKTN, genes causing WWS, by dideoxy sequence analysis. Results We identified an identical homozygous c.1167insA mutation in the FKTN gene on a common haplotype in all four families and identified 2/299 (0.7%) carriers for the c.1167insA mutation among normal American Ashkenazi Jewish adults. Conclusion These data suggest that the c.1167insA FKTN mutation described by us is a founder mutation that can be used to target diagnostic testing and carrier screening in the Ashkenazi Jewish population. PMID:19266496

Founder Fukutin mutation causes Walker-Warburg syndrome in four Ashkenazi Jewish families.

PubMed

Chang, Wendy; Winder, Thomas L; LeDuc, Charles A; Simpson, Lynn L; Millar, William S; Dungan, Jeffrey; Ginsberg, Norman; Plaga, Stacey; Moore, Steven A; Chung, Wendy K

2009-06-01

Walker-Warburg syndrome (WWS) is a genetically heterogeneous congenital muscular dystrophy caused by abnormal glycosylation of alpha-dystroglycan (alpha-DG) that is associated with brain malformations and eye anomalies. The Fukutin (FKTN) gene, which causes autosomal recessively inherited WWS is most often associated with Fukuyama congenital muscular dystrophy in Japan. We describe the clinical features of four nonconsanguinous Ashkenazi Jewish families with WWS and identify the underlying genetic basis for WWS. We screened for mutations in POMGnT1, POMT1, POMT2, and FKTN, genes causing WWS, by dideoxy sequence analysis. We identified an identical homozygous c.1167insA mutation in the FKTN gene on a common haplotype in all four families and identified 2/299 (0.7%) carriers for the c.1167insA mutation among normal American Ashkenazi Jewish adults. These data suggest that the c.1167insA FKTN mutation described by us is a founder mutation that can be used to target diagnostic testing and carrier screening in the Ashkenazi Jewish population. Copyright (c) 2009 John Wiley & Sons, Ltd.

NASA Pathways: Intern Employment Program Work Report Summer 2014

NASA Technical Reports Server (NTRS)

Davidson, Kyle B.

2014-01-01

This report documents the work experience and project involvement of Kyle Davidson during his tenure at Kennedy Space Center for the summer of 2014. Projects include the Nitrogen Oxygen Recharge System (NORS), Restore satellite servicing program, and mechanical handling operations for the SAGE III and Rapidscat payloads.

Perspective Transformation through College Summer Service Immersion Programs: Is Learning Enhanced by Sustained Engagement?

ERIC Educational Resources Information Center

Hudson, Tara D.; Serra, Susan; Shappell, Andrea Smith; Gray-Girton, Angela; Brandenberger, Jay

2017-01-01

Summer offers the opportunity for sustained community engagement through immersions in summer service-learning programs. A group of 16 colleges and universities that sponsor domestic and international summer service initiatives have formed a Summer Service Collaborative (SSC) to enhance preparation, immersion, and follow-up in light of the unique…

2-Deoxyglucose induces the expression of thioredoxin interacting protein (TXNIP) by increasing O-GlcNAcylation – Implications for targeting the Warburg effect in cancer cells

DOE Office of Scientific and Technical Information (OSTI.GOV)

Hong, Shin Yee; Hagen, Thilo, E-mail: bchth@nus.edu.sg

2015-10-02

The high proliferation rate of cancer cells and the microenvironment in the tumor tissue require the reprogramming of tumor cell metabolism. The major mechanism of metabolic reprogramming in cancer cells is the Warburg effect, defined as the preferential utilization of glucose via glycolysis even in the presence of oxygen. Targeting the Warburg effect is considered as a promising therapeutic strategy in cancer therapy. In this regard, the glycolytic inhibitor 2-deoxyglucose (2DG) has been evaluated clinically. 2DG exerts its effect by directly inhibiting glycolysis at the level of hexokinase and phosphoglucoisomerase. In addition, 2DG is also known to induce the expressionmore » of thioredoxin interacting protein (TXNIP), a tumor suppressor protein and an important negative regulator of cellular glucose uptake. Hence, characterization of the mechanism through which 2DG regulates TXNIP expression may reveal novel approaches to target the Warburg effect in cancer cells. Therefore, in this study we sought to test various hypotheses for the mechanistic basis of the 2DG dependent TXNIP regulation. We have shown that 2DG induced TXNIP expression is independent of carbohydrate response element mediated transcription. Furthermore, the induction of TXNIP is neither dependent on the ability of 2DG to deplete cellular ATP nor to cause endoplasmic reticulum stress. We found that the 2DG induced TXNIP expression is at least in part dependent on the inhibition of the O-GlcNAcase enzyme and the accumulation of O-GlcNAc modified proteins. These results have implications for the identification of therapeutic targets to increase TXNIP expression in cancer. - Highlights: • 2DG increases TXNIP expression at the mRNA and protein level. • The effect of 2DG on TXNIP is independent of ChoRE mediated transcription. • 2DG induces TXNIP independent of ER stress induction and ATP depletion. • 2DG inhibits OGA and leads to accumulation of O-GlcNAcylated proteins. • The upregulation

Trust Building as a Strategy to Avoid Unintended Consequences of Education. The Case Study of International Summer Camps Designed to Promote Peace and Intercultural Dialogue among Adolescents

ERIC Educational Resources Information Center

Farini, Federico

2014-01-01

This article aims to offer both a theoretical contribution and examples of practices of trust building in peace education; the article presents an empirical analysis of videotaped interactions in the context of peace education activities in international groups of adolescents. The analysis regards two international summer camps promoted by the…

PREFACE: Third International Workshop & Summer School on Plasma Physics 2008

NASA Astrophysics Data System (ADS)

Benova, E.; Dias, F. M.; Lebedev, Yu

2010-01-01

The Third International Workshop & Summer School on Plasma Physics (IWSSPP'08) organized by St Kliment Ohridsky University of Sofia, with co-organizers TCPA Foundation, Association EURATOM/IRNRE, The Union of the Physicists in Bulgaria, and the Bulgarian Academy of Sciences was held in Kiten, Bulgaria, at the Black Sea Coast, from 30 June to 5 July 2008. A Special Session on Plasmas for Environmental Issues was co-organised by the Institute of Plasmas and Nuclear Fusion, Lisbon, Portugal and the Laboratory of Plasmas and Energy Conversion, University of Toulouse, France. That puts the beginning of a series in Workshops on Plasmas for Environmental Issues, now as a satellite meeting of the European Physical Society Conference on Plasma Physics. As the previous issues of this scientific meeting (IWSSPP'05, J. Phys.: Conf. Series 44 (2006) and IWSSPP'06, J. Phys.: Conf. Series 63 (2007)), its aim was to stimulate the creation and support of a new generation of young scientists for further development of plasma physics fundamentals and applications, as well as to ensure an interdisciplinary exchange of views and initiate possible collaborations by bringing together scientists from various branches of plasma physics. This volume of Journal of Physics: Conference Series includes 38 papers (invited lectures, contributed talks and posters) devoted to various branches of plasma physics, among them fusion plasma and materials, dc and microwave discharge modelling, transport phenomena in gas discharge plasmas, plasma diagnostics, cross sections and rate constants of elementary processes, material processing, plasma-chemistry and technology. Some of them have been presented by internationally known and recognized specialists in their fields; others are MSc or PhD students' first steps in science. In both cases, we believe they will raise readers' interest. We would like to thank the members of both the International Advisory Committee and the Local Organizing Committee, the

EGF induces epithelial-mesenchymal transition and cancer stem-like cell properties in human oral cancer cells via promoting Warburg effect.

PubMed

Xu, Qilin; Zhang, Qunzhou; Ishida, Yasutaka; Hajjar, Souren; Tang, Xudong; Shi, Haoran; Dang, Chi V; Le, Anh D

2017-02-07

"Warburg effect", the enhanced glycolysis or aerobic glycolysis, confers cancer cells the ability to survive and proliferate even under stressed conditions. In this study, we explored the role of epidermal growth factor (EGF) in orchestrating Warburg effect, the epithelial-mesenchymal transition (EMT) process, and the acquisition of cancer stem-like cell properties in human oral squamous cell carcinoma (OSCC) cells. Our results showed that EGF induces EMT process in OSCC cells, which correlates with the acquisition of cancer stem-like properties, including the enrichment of CD44+/CD24- population of cancer cells and an increased expression of CSC-related genes, aldehyde dehydrogenase-1 (ALDH1) and Bmi-1. We also showed that EGF concomitantly enhanced L-lactate production, while blocking glycolysis by 2-deoxy-D-glucose (2-DG) robustly reversed EGF-induced EMT process and CSC-like properties in OSCC cells. Mechanistically, we demonstrated that EGF promoted EMT process and CSC generation through EGFR/PI3K/HIF-1α axis-orchestrated glycolysis. Using an orthotopic tumor model of human OSCC (UM-SCC1) injected in the tongue of BALB/c nude mice, we showed that treatment with 2-DG in vivo significantly inhibited the metastasis of tumor cells to the regional cervical lymph nodes and reduced the expression of ALDH1 and vimentin in both in situ tumors and tumor cell-invaded regional lymph nodes. Taken together, these findings have unveiled a new mechanism that EGF drives OSCC metastasis through induction of EMT process and CSC generation, which is driven by an enhanced glycolytic metabolic program in OSCC cells.

Cancer and Exercise: Warburg Hypothesis, Tumour Metabolism and High-Intensity Anaerobic Exercise.

PubMed

Hofmann, Peter

2018-01-31

There is ample evidence that regular moderate to vigorous aerobic physical activity is related to a reduced risk for various forms of cancer to suggest a causal relationship. Exercise is associated with positive changes in fitness, body composition, and physical functioning as well as in patient-reported outcomes such as fatigue, sleep quality, or health-related quality of life. Emerging evidence indicates that exercise may also be directly linked to the control of tumour biology through direct effects on tumour-intrinsic factors. Beside a multitude of effects of exercise on the human body, one underscored effect of exercise training is to target the specific metabolism of tumour cells, namely the Warburg-type highly glycolytic metabolism. Tumour metabolism as well as the tumour⁻host interaction may be selectively influenced by single bouts as well as regularly applied exercise, dependent on exercise intensity, duration, frequency and mode. High-intensity anaerobic exercise was shown to inhibit glycolysis and some studies in animals showed that effects on tumour growth might be stronger compared with moderate-intensity aerobic exercise. High-intensity exercise was shown to be safe in patients; however, it has to be applied carefully with an individualized prescription of exercise.

The Warburg effect: persistence of stem-cell metabolism in cancers as a failure of differentiation.

PubMed

Riester, M; Xu, Q; Moreira, A; Zheng, J; Michor, F; Downey, R J

2018-01-01

Two recent observations regarding the Warburg effect are that (i) the metabolism of stem cells is constitutive (aerobic) glycolysis while normal cellular differentiation involves a transition to oxidative phosphorylation and (ii) the degree of glucose uptake of a malignancy as imaged by 18F-fluorodeoxyglucose positron emission tomography (FDG-PET) is associated with histologic measures of tumor differentiation. Combining these observations, we hypothesized that the high levels of glucose uptake observed in poorly differentiated cancers may reflect persistence of the glycolytic metabolism of stem cells in malignant cells that fail to fully differentiate. Tumor glucose uptake was measured by FDG-PET in 552 patients with histologically diverse cancers. We used normal mixture modeling to explore FDG-PET standardized uptake value (SUV) distributions and tested for associations between glucose uptake and histological differentiation, risk of lymph node metastasis, and survival. Using RNA-seq data, we carried out pathway and transcription factor analyses to compare tumors with high and low levels of glucose uptake. We found that well-differentiated tumors had low FDG uptake, while moderately and poorly differentiated tumors had higher uptake. The distribution of SUV for each histology was bimodal, with a low peak around SUV 2-5 and a high peak at SUV 8-14. The cancers in the two modes were clinically distinct in terms of the risk of nodal metastases and death. Carbohydrate metabolism and the pentose-related pathway were elevated in the poorly differentiated/high SUV clusters. Embryonic stem cell-related signatures were activated in poorly differentiated/high SUV clusters. Our findings support the hypothesis that the biological basis for the Warburg effect is a persistence of stem cell metabolism (i.e. aerobic glycolysis) in cancers as a failure to transition from glycolysis-utilizing undifferentiated cells to oxidative phosphorylation-utilizing differentiated cells. We

Internal variability in European summer temperatures at 1.5 °C and 2 °C of global warming

NASA Astrophysics Data System (ADS)

Suarez-Gutierrez, Laura; Li, Chao; Müller, Wolfgang A.; Marotzke, Jochem

2018-06-01

We use the 100-member Grand Ensemble with the climate model MPI-ESM to evaluate the controllability of mean and extreme European summer temperatures with the global mean temperature targets in the Paris Agreement. We find that European summer temperatures at 2 °C of global warming are on average 1 °C higher than at 1.5 °C of global warming with respect to pre-industrial levels. In a 2 °C warmer world, one out of every two European summer months would be warmer than ever observed in our current climate. Daily maximum temperature anomalies for extreme events with return periods of up to 500 years reach return levels of 7 °C at 2 °C of global warming and 5.5 °C at 1.5 °C of global warming. The largest differences in return levels for shorter return periods of 20 years are over southern Europe, where we find the highest mean temperature increase. In contrast, for events with return periods of over 100 years these differences are largest over central Europe, where we find the largest changes in temperature variability. However, due to the large effect of internal variability, only four out of every ten summer months in a 2 °C warmer world present mean temperatures that could be distinguishable from those in a 1.5 °C world. The distinguishability between the two climates is largest over southern Europe, while decreasing to around 10% distinguishable months over eastern Europe. Furthermore, we find that 10% of the most extreme and severe summer maximum temperatures in a 2 °C world could be avoided by limiting global warming to 1.5 °C.

Effect of Daytime Blue-enriched LED Light on the Nighttime Circadian Melatonin Inhibition of Hepatoma 7288CTC Warburg Effect and Progression.

PubMed

Dauchy, Robert T; Wren-Dail, Melissa A; Dupepe, Lynell M; Hill, Steven M; Xiang, Shulin; Anbalagan, Muralidharan; Belancio, Victoria P; Dauchy, Erin M; Blask, David E

2018-06-06

Liver cancer is the second leading cause of cancer death worldwide. Metabolic pathways within the liver and liver cancersare highly regulated by the central circadian clock in the suprachiasmatic nuclei (SCN). Daily light and dark cycles regulate the SCN-driven pineal production of the circadian anticancer hormone melatonin and temporally coordinate circadianrhythms of metabolism and physiology in mammals. In previous studies, we demonstrated that melatonin suppresses linoleicacid metabolism and the Warburg effect (aerobic glycolysis)in human breast cancer xenografts and that blue-enriched light(465-485 nm) from light-emitting diode lighting at daytime (bLAD) amplifies nighttime circadian melatonin levels in ratsby 7-fold over cool white fluorescent (CWF) lighting. Here we tested the hypothesis that daytime exposure of tissue-isolatedMorris hepatoma 7288CTC-bearing male rats to bLAD amplifies the nighttime melatonin signal to enhance the inhibition oftumor growth. Compared with rats housed under a 12:12-h light:dark cycle in CWF light, rats in bLAD light evinced a 7-fold higher peak plasma melatonin level at the mid-dark phase; in addition, high melatonin levels were prolonged until 4 h intothe light phase. After implantation of tissue-isolated hepatoma 7288CTC xenografts, tumor growth rates were markedly delayed,and tumor cAMP levels, LA metabolism, the Warburg effect, and growth signaling activities were decreased in rats inbLAD compared with CWF daytime lighting. These data show that the increased nighttime circadian melatonin levels dueto bLAD exposure decreases hepatoma metabolic, signaling, and proliferative activities beyond what occurs after normalmelatonin signaling under CWF light.

The International Summer School on Land Cover Change and Hydroclimate of the La Plata Basin

NASA Technical Reports Server (NTRS)

Berbery, Ernesto Hugo; Herdies, Dirceu L.; Alcaraz-Segura, Domingo; de Goncalves, Luis G. G.; Lettenmaier, Dennis P.; Toll, David

2011-01-01

The La Plata Basin (LPB) in southern South America has been subject to land cover and land use changes (LCLUCs) since colonial times and with an accelerated rate in the last decades and over extensive areas. The work of Ameghino even suggested that there were relations between those land use changes and the frequency of droughts and floods in the region. Despite this early knowledge, not much is known of the potential impacts of LCLUC on the hydroclimate of the La Plata basin. Besides, over the last century much of the La Plata Basin has had a reported increase in precipitation and heavy rains, and these changes along with an increase in population growth - have resulted in more adverse effects from flooding. To draw attention to these issues, during two weeks in November 2009 the International Summer School on Land Cover Change and Hydroclimate of the La Plata Basin was organized at the grounds of the Itaip Hydropower Plant in Brazil. The school was the result of the combination of interests between the La Plata Basin Regional Hydroclimate Project, the Inter-American Institute for Global Change Research (IAI), and the International Hydroinformatics Center (IHC) in Itaip . LPB is an umbrella project endorsed by the Global Energy and Water Cycle Experiment (GEWEX) and the Climate Prediction and Variability (CLIVAR), both of the World Climate Research Programme (WCRP). LPB has made a priority to train young scientists and promote interdisciplinary collaborations in areas related to Climate, Hydrology, Ecology and Agriculture. The IAI, with a similar agenda, was a natural partner to develop this Summer School, which in turn benefited from Itaipu s interest in relating with the scientific community of neighboring countries. The choice of location (Itaip Technological Park) was made so that participants could relate research usually done at academic institutions to applications and operations at one of the largest hydropower plants in the world. The school was attended

The Summer School Alpbach

NASA Astrophysics Data System (ADS)

Gitsch, Michaela; Manoharan, Periasamy K.

2015-02-01

Sixty young, highly qualified European science and engineering students converge annually for stimulating 10 days of work in the Austrian Alps. Four teams are formed, each of which designs a space mission, which are then judged by a jury of experts. Students learn how to approach the design of a satellite mission and explore new and startling ideas supported by experts. The Summer School Alpbach enjoys more than 30 years of tradition in providing in-depth teaching on different topics of space science and space technology, featuring lectures and concentrated working sessions on mission studies in self-organised working groups. The Summer School is organised by the Austrian Research Promotion Agency (FFG) and co-sponsored by the European Space Agency (ESA), the International Space Science Institute (ISSI), and the national space authorities of its member and cooperating states.

MtDNA depleted PC3 cells exhibit Warburg effect and cancer stem cell features

PubMed Central

Li, Xiaoran; Zhong, Yali; Lu, Jie; Axcrona, Karol; Eide, Lars; Syljuåsen, Randi G.; Peng, Qian; Wang, Junbai; Zhang, Hongquan; Goscinski, Mariusz Adam; Kvalheim, Gunnar; Nesland, Jahn M.; Suo, Zhenhe

2016-01-01

Reducing mtDNA content was considered as a critical step in the metabolism restructuring for cell stemness restoration and further neoplastic development. However, the connections between mtDNA depletion and metabolism reprograming-based cancer cell stemness in prostate cancers are still lack of studies. Here, we demonstrated that human CRPC cell line PC3 tolerated high concentration of the mtDNA replication inhibitor ethidium bromide (EtBr) and the mtDNA depletion triggered a universal metabolic remodeling process. Failure in completing that process caused lethal consequences. The mtDNA depleted (MtDP) PC3 cells could be steadily maintained in the special medium in slow cycling status. The MtDP PC3 cells contained immature mitochondria and exhibited Warburg effect. Furthermore, the MtDP PC3 cells were resistant to therapeutic treatments and contained greater cancer stem cell-like subpopulations: CD44+, ABCG2+, side-population and ALDHbright. In conclusion, these results highlight the association of mtDNA content, mitochondrial function and cancer cell stemness features. PMID:27248169

The environmental carcinogen benzo[a]pyrene induces a Warburg-like metabolic reprogramming dependent on NHE1 and associated with cell survival

PubMed Central

Hardonnière, Kévin; Saunier, Elise; Lemarié, Anthony; Fernier, Morgane; Gallais, Isabelle; Héliès-Toussaint, Cécile; Mograbi, Baharia; Antonio, Samantha; Bénit, Paule; Rustin, Pierre; Janin, Maxime; Habarou, Florence; Ottolenghi, Chris; Lavault, Marie-Thérèse; Benelli, Chantal; Sergent, Odile; Huc, Laurence; Bortoli, Sylvie; Lagadic-Gossmann, Dominique

2016-01-01

Cancer cells display alterations in many cellular processes. One core hallmark of cancer is the Warburg effect which is a glycolytic reprogramming that allows cells to survive and proliferate. Although the contributions of environmental contaminants to cancer development are widely accepted, the underlying mechanisms have to be clarified. Benzo[a]pyrene (B[a]P), the prototype of polycyclic aromatic hydrocarbons, exhibits genotoxic and carcinogenic effects, and it is a human carcinogen according to the International Agency for Research on Cancer. In addition to triggering apoptotic signals, B[a]P may induce survival signals, both of which are likely to be involved in cancer promotion. We previously suggested that B[a]P-induced mitochondrial dysfunctions, especially membrane hyperpolarization, might trigger cell survival signaling in rat hepatic epithelial F258 cells. Here, we further characterized these dysfunctions by focusing on energy metabolism. We found that B[a]P promoted a metabolic reprogramming. Cell respiration decreased and lactate production increased. These changes were associated with alterations in the tricarboxylic acid cycle which likely involve a dysfunction of the mitochondrial complex II. The glycolytic shift relied on activation of the Na+/H+ exchanger 1 (NHE1) and appeared to be a key feature in B[a]P-induced cell survival related to changes in cell phenotype (epithelial-to-mesenchymal transition and cell migration). PMID:27488617

A DERL3-associated defect in the degradation of SLC2A1 mediates the Warburg effect

PubMed Central

Lopez-Serra, Paula; Marcilla, Miguel; Villanueva, Alberto; Ramos-Fernandez, Antonio; Palau, Anna; Leal, Lucía; Wahi, Jessica E.; Setien-Baranda, Fernando; Szczesna, Karolina; Moutinho, Catia; Martinez-Cardus, Anna; Heyn, Holger; Sandoval, Juan; Puertas, Sara; Vidal, August; Sanjuan, Xavier; Martinez-Balibrea, Eva; Viñals, Francesc; Perales, Jose C.; Bramsem, Jesper B.; Ørntoft, Torben F.; Andersen, Claus L.; Tabernero, Josep; McDermott, Ultan; Boxer, Matthew B.; Heiden, Matthew G. Vander; Albar, Juan Pablo; Esteller, Manel

2014-01-01

Cancer cells possess aberrant proteomes that can arise by the disruption of genes involved in physiological protein degradation. Here we demonstrate the presence of promoter CpG island hypermethylation-linked inactivation of DERL3 (Derlin-3), a key gene in the endoplasmic reticulum-associated protein degradation pathway, in human tumours. The restoration of in vitro and in vivo DERL3 activity highlights the tumour suppressor features of the gene. Using the stable isotopic labelling of amino acids in cell culture workflow for differential proteome analysis, we identify SLC2A1 (glucose transporter 1, GLUT1) as a downstream target of DERL3. Most importantly, SLC2A1 overexpression mediated by DERL3 epigenetic loss contributes to the Warburg effect in the studied cells and pinpoints a subset of human tumours with greater vulnerability to drugs targeting glycolysis. PMID:24699711

Germline BAP1 mutations induce a Warburg effect

PubMed Central

Bononi, Angela; Yang, Haining; Giorgi, Carlotta; Patergnani, Simone; Pellegrini, Laura; Su, Mingming; Xie, Guoxiang; Signorato, Valentina; Pastorino, Sandra; Morris, Paul; Sakamoto, Greg; Kuchay, Shafi; Gaudino, Giovanni; Pass, Harvey I; Napolitano, Andrea; Pinton, Paolo; Jia, Wei; Carbone, Michele

2017-01-01

Carriers of heterozygous germline BAP1 mutations (BAP1+/−) develop cancer. We studied plasma from 16 BAP1+/− individuals from 2 families carrying different germline BAP1 mutations and 30 BAP1 wild-type (BAP1WT) controls from these same families. Plasma samples were analyzed by liquid chromatography time-of-flight mass spectrometry (LC-TOF-MS), ultra-performance liquid chromatography triple quadrupole mass spectrometry (UPLC-TQ-MS), and gas chromatography time-of-flight mass spectrometry (GC-TOF-MS). We found a clear separation in the metabolic profile between BAP1WT and BAP1+/− individuals. We confirmed the specificity of the data in vitro using 12 cell cultures of primary fibroblasts we derived from skin punch biopsies from 12/46 of these same individuals, 6 BAP1+/− carriers and 6 controls from both families. BAP1+/− fibroblasts displayed increased aerobic glycolysis and lactate secretion, and reduced mitochondrial respiration and ATP production compared with BAP1WT. siRNA-mediated downregulation of BAP1 in primary BAP1WT fibroblasts and in primary human mesothelial cells, led to the same reduced mitochondrial respiration and increased aerobic glycolysis as we detected in primary fibroblasts from carriers of BAP1+/− mutations. The plasma and cell culture results were highly reproducible and were specifically and only linked to BAP1 status and not to gender, age or family, or cell type, and required an intact BAP1 catalytic activity. Accordingly, we were able to build a metabolomic model capable of predicting BAP1 status with 100% accuracy using data from human plasma. Our data provide the first experimental evidence supporting the hypothesis that aerobic glycolysis, also known as the ‘Warburg effect’, does not necessarily occur as an adaptive process that is consequence of carcinogenesis, but rather that it may also predate malignancy by many years and facilitate carcinogenesis. PMID:28665402

The News, Summer 1999-Summer 2000.

ERIC Educational Resources Information Center

Robertson, Trische, Ed.

2000-01-01

This document contains five quarterly issues of The News, published Summer 1999 through Summer 2000 by the Community College League of California. The following items are contained in this document: "Grant Writing Success Depends on Resources, Information and Staff,""College Theaters Perform Balancing Act with Community,…

2003 SOLAS Summer School

NASA Technical Reports Server (NTRS)

McGillis, Wade R.

2003-01-01

In 2003, the United States provided support for the participation of 18 students, three research assistants, and seven lecturers in the first international Surface Ocean Lower Atmosphere Study (SOLAS) Summer School. The purpose of this school was to introduce graduate students and young researchers to different components of SOLAS research including biogeochemical interactions and feedbacks, exchange processes, and air-sea fluxes. Support was provided through grants from: NASA (contact: Charles Trees); NSF (contact: Anne-Marie Schmoltner); NOAA (contact: Kathy Tedesco); and ONR (contact: Ronald Ferek).

My Summer with Science Policy

NASA Astrophysics Data System (ADS)

Murray, Marissa

This past summer I interned at the American Institute of Physics and helped research and write articles for the FYI Science Policy Bulletin. FYI is an objective digest of science policy developments in Washington, D.C. that impact the greater physical sciences community. Over the course of the summer, I independently attended, analyzed, and reported on a variety of science, technology, and funding related events including congressional hearings, government agency advisory committee meetings, and scientific society events. I wrote and co-wrote three articles on basic energy research legislation, the National Institute of Standards and Technology improvement act, and the National Science Foundation's big ideas for future investment. I had the opportunity to examine some challenging questions such as what is the role of government in funding applied research? How should science priorities be set? What is the right balance of funding across different agencies and programs? I learned about how science policy is a two-way street: science is used to inform policy decisions and policy is made to fund and regulate the conduct of science. I will conclude with how my summer working with FYI showed me the importance of science advocacy, being informed, and voting. Society of Physics Students.

The 2013 Summer Undergraduate Research Internship Program at the Pisgah Astronomical Research Institute

NASA Astrophysics Data System (ADS)

Castelaz, Michael W.; Cline, J. D.; Whitworth, C.; Clavier, D.; Barker, T.

2014-01-01

Pisgah Astronomical Research Institute (PARI) offers summer undergraduate research internships. PARI has received support for the internships from the EMC Corporation, private donations, private foundations, and through a collaboration with the Pisgah Astronomical Research and Education Center of the University of North Carolina - Asheville. The internship program began in 2001 with 4 students. This year 10 funded students participated. Mentors for the interns include PARI’s Directors of Science, Education, and Information Technology and visiting faculty who are members of the PARI Research Faculty Affiliate program. Students work with mentors on radio and optical astronomy research, electrical engineering for robotic control of instruments, software development for instrument control and and science education by developing curricula and multimedia and teaching high school students in summer programs at PARI. At the end of the summer interns write a paper about their research which is published in the PARI Summer Student Proceedings. Students are encouraged to present their research at AAS Meetings. We will present a summary of specific research conducted by the students with their mentors.

Application Deadlines - CPFP Summer Curriculum in Cancer Prevention Courses 2016 | Division of Cancer Prevention

Cancer.gov

The National Cancer Institute (NCI) Cancer Prevention Fellowship Program (CPFP) is now accepting applications for the Summer Curriculum in Cancer Prevention until February 26, 2016 for international applicants and March 15, 2016 for domestic applicants. For more information and to apply, please visit: https://cpfp.cancer.gov/summer-curriculum. |

Engaging minority high school students as health disparities interns: findings and policy implications of a summer youth pipeline program.

PubMed

Rashied-Henry, Kweli; Fraser-White, Marilyn; Roberts, Calpurnyia B; Wilson, Tracey E; Morgan, Rochelle; Brown, Humberto; Shaw, Raphael; Jean-Louis, Girardin; Graham, Yvonne J; Brown, Clinton; Browne, Ruth

2012-01-01

The purpose of this paper was to describe the development and implementation of a health disparities summer internship program for minority high school students that was created to increase their knowledge of health disparities, provide hands-on training in community-engaged research, support their efforts to advocate for policy change, and further encourage youth to pursue careers in the health professions. Fifty-one high school students who were enrolled in a well-established, science-enrichment after-school program in Brooklyn, New York, participated in a 4-week summer internship program. Students conducted a literature review, focus groups/interviews, geographic mapping or survey development that focused on reducing health disparities at 1 of 15 partnering CBOs. Overall, student interns gained an increase in knowledge of racial/ethnic health disparities. There was a 36.2% increase in students expressing an interest in pursuing careers in minority health post program. The majority of the participating CBOs were able to utilize the results of the student-led research projects for their programs. In addition, research conclusions and policy recommendations based on the students' projects were given to local elected officials. As demonstrated by our program, community-academic partnerships can provide educational opportunities to strengthen the academic pipeline for students of color interested in health careers and health disparities research.

HK2 Recruitment to Phospho-BAD Prevents Its Degradation, Promoting Warburg Glycolysis by Theileria-Transformed Leukocytes.

PubMed

Haidar, Malak; Lombès, Anne; Bouillaud, Frédéric; Kennedy, Eileen J; Langsley, Gordon

2017-03-10

Theileria annulata infects bovine leukocytes, transforming them into invasive, cancer-like cells that cause the widespread disease called tropical theileriosis. We report that in Theileria-transformed leukocytes hexokinase-2 (HK2) binds to B cell lymphoma-2-associated death promoter (BAD) only when serine (S) 155 in BAD is phosphorylated. We show that HK2 recruitment to BAD is abolished by a cell-penetrating peptide that acts as a nonphosphorylatable BAD substrate that inhibits endogenous S155 phosphorylation, leading to complex dissociation and ubiquitination and degradation of HK2 by the proteasome. As HK2 is a critical enzyme involved in Warburg glycolysis, its loss forces Theileria-transformed macrophages to switch back to HK1-dependent oxidative glycolysis that down-regulates macrophage proliferation only when they are growing on glucose. When growing on galactose, degradation of HK2 has no effect on Theileria-infected leukocyte proliferation, because metabolism of this sugar is independent of hexokinases. Thus, targeted disruption of the phosphorylation-dependent HK2/BAD complex may represent a novel approach to control Theileria-transformed leukocyte proliferation.

Arctic summer school onboard an icebreaker

NASA Astrophysics Data System (ADS)

Alexeev, Vladimir A.; Repina, Irina A.

2014-05-01

The International Arctic Research Center (IARC) of the University of Alaska Fairbanks conducted a summer school for PhD students, post-docs and early career scientists in August-September 2013, jointly with an arctic expedition as a part of NABOS project (Nansen and Amundsen Basin Observational System) onboard the Russian research vessel "Akademik Fedorov". Both the summer school and NABOS expedition were funded by the National Science Foundation. The one-month long summer school brought together graduate students and young scientists with specialists in arctic oceanography and climate to convey to a new generation of scientists the opportunities and challenges of arctic climate observations and modeling. Young scientists gained hands-on experience during the field campaign and learned about key issues in arctic climate from observational, diagnostic, and modeling perspectives. The summer school consisted of background lectures, participation in fieldwork and mini-projects. The mini-projects were performed in collaboration with summer school instructors and members of the expedition. Key topics covered in the lectures included: - arctic climate: key characteristics and processes; - physical processes in the Arctic Ocean; - sea ice and the Arctic Ocean; - trace gases, aerosols, and chemistry: importance for climate changes; - feedbacks in the arctic system (e.g., surface albedo, clouds, water vapor, circulation); - arctic climate variations: past, ongoing, and projected; - global climate models: an overview. An outreach specialist from the Miami Science Museum was writing a blog from the icebreaker with some very impressive statistics (results as of January 1, 2014): Total number of blog posts: 176 Blog posts written/contributed by scientists: 42 Blog views: 22,684 Comments: 1,215 Number of countries who viewed the blog: 89 (on 6 continents) The 33-day long NABOS expedition started on August 22, 2013 from Kirkenes, Norway. The vessel ("Akademik Fedorov") returned to

Summary Report of Summer 2009 NGSI Human Capital Development Efforts at Lawrence Livermore National Laboratory

DOE Office of Scientific and Technical Information (OSTI.GOV)

Dougan, A; Dreicer, M; Essner, J

2009-11-16

In 2009, Lawrence Livermore National Laboratory (LLNL) engaged in several activities to support NA-24's Next Generation Safeguards Initiative (NGSI). This report outlines LLNL's efforts to support Human Capital Development (HCD), one of five key components of NGSI managed by Dunbar Lockwood in the Office of International Regimes and Agreements (NA-243). There were five main LLNL summer safeguards HCD efforts sponsored by NGSI: (1) A joint Monterey Institute of International Studies/Center for Nonproliferation Studies-LLNL International Safeguards Policy and Information Analysis Course; (2) A Summer Safeguards Policy Internship Program at LLNL; (3) A Training in Environmental Sample Analysis for IAEA Safeguards Internship;more » (4) Safeguards Technology Internships; and (5) A joint LLNL-INL Summer Safeguards Lecture Series. In this report, we provide an overview of these five initiatives, an analysis of lessons learned, an update on the NGSI FY09 post-doc, and an update on students who participated in previous NGSI-sponsored LLNL safeguards HCD efforts.« less

Making Summer Count: How Summer Programs Can Boost Children's Learning

ERIC Educational Resources Information Center

McCombs, Jennifer Sloan; Augustine, Catherine; Schwartz, Heather; Bodilly, Susan; McInnis, Brian; Lichter, Dahlia; Cross, Amanda Brown

2012-01-01

During summer vacation, many students lose knowledge and skills. By the end of summer, students perform, on average, one month behind where they left off in the spring. Participation in summer learning programs should mitigate learning loss and could even produce achievement gains. Indeed, educators and policymakers increasingly promote summer…

Alpbach Summer School - a unique learning experience

NASA Astrophysics Data System (ADS)

Kern, K.; Aulinas, J.; Clifford, D.; Krejci, D.; Topham, R.

2011-12-01

The Alpbach Summer School is a ten-day program that provides a unique opportunity for young european science and engineering students, both undergraduate and graduate, to learn how to approach the entire design process of a space mission. The theme of the 2010 Summer School was "New Space Missions to Understand Climate Change", a current, challenging, very broad and complex topic. The program was established more than 35 years ago and is organised in two interrelated parts: a series of lectures held by renowned experts in the field (in the case of this specific year, climate change and space engineering experts) that provides a technical and scientific background for the workshops that follow, the core of the Summer School. For the workshops the students are split into four international, interdisciplinary teams of about 15 students. In 2010 every team had to complete a number of tasks, four in total: (1) identify climate change research gaps and design a space mission that has not yet been flown or proposed, (2) define the science objectives and requirements of the mission, (3) design a spacecraft that meets the mission requirements, which includes spacecraft design and construction, payload definition, orbit calculations, but also the satellite launch, operation and mission costs and (4) write up a short mission proposal and present the results to an expert review panel. Achieving these tasks in only a few days in a multicultural, interdisciplinary team represents a major challenge for all participants and provides an excellent practical learning experience. Over the course of the program, students do not just learn facts about climate change and space engineering, but scientists also learn from engineers and engineers from scientists. The participants have to deepen their knowledge in an often unfamiliar field, develop organisational and team-work skills and work under pressure. Moreover, teams are supported by team and roving tutors and get the opportunity to

Morphometric changes in Yellow-headed Blackbirds during summer in central North Dakota

USGS Publications Warehouse

Twedt, D.J.; Linz, G.M.

2002-01-01

Temporal stability of morphometric measurements is desirable when using avian morphology as a predictor of geographic origin. Therefore, to assess their temporal stability, we examined changes in morphology of Yellow-headed Blackbirds (Xanthocephalus xanthocephalus) from central North Dakota during summer. Measurements differed among age classes and between sexes. As expected, due to growth and maturation, measurements on hatching-year birds increased over summer. Measurements of adult plumage fluctuated with prebasic molt and exhibited age-specific discontinuities. Body mass of adult birds increased over summer, whereas both culmen length and skull length decreased. Only body length and length of internal skeletal elements were temporally stable in adult Yellow-headed Blackbirds.

Monitoring Mitochondrial Pyruvate Carrier Activity in Real Time Using a BRET-Based Biosensor: Investigation of the Warburg Effect.

PubMed

Compan, Vincent; Pierredon, Sandra; Vanderperre, Benoît; Krznar, Petra; Marchiq, Ibtissam; Zamboni, Nicola; Pouyssegur, Jacques; Martinou, Jean-Claude

2015-08-06

The transport of pyruvate into mitochondria requires a specific carrier, the mitochondrial pyruvate carrier (MPC). The MPC represents a central node of carbon metabolism, and its activity is likely to play a key role in bioenergetics. Until now, investigation of the MPC activity has been limited. However, the recent molecular identification of the components of the carrier has allowed us to engineer a genetically encoded biosensor and to monitor the activity of the MPC in real time in a cell population or in a single cell. We report that the MPC activity is low in cancer cells, which mainly rely on glycolysis to generate ATP, a characteristic known as the Warburg effect. We show that this low activity can be reversed by increasing the concentration of cytosolic pyruvate, thus increasing oxidative phosphorylation. This biosensor represents a unique tool to investigate carbon metabolism and bioenergetics in various cell types. Copyright © 2015 Elsevier Inc. All rights reserved.

2012 Summer Research Experiences for Undergraduates at Pisgah Astronomical Research Institute

NASA Astrophysics Data System (ADS)

Castelaz, Michael W.; Cline, J. D.; Whitworth, C.; Clavier, D.; Owen, L.

2013-01-01

Pisgah Astronomical Research Institute (PARI) offers research experiences for undergraduates (REU). PARI receives support for the internships from the NC Space Grant Consortium, NSF awards, private donations, and industry partner funding. The PARI REU program began in 2001 with 4 students and has averaged 6 students per year over the past 11 years. This year PARI hosted 8 funded REU students. Mentors for the interns include PARI’s Science, Education, and Information Technology staff and visiting faculty who are members of the PARI Research Faculty Affiliate program. Students work with mentors on radio and optical astronomy research, electrical engineering for robotic control of instruments, software development for instrument control and software for citizen science projects, and science education by developing curricula and multimedia and teaching high school students in summer programs at PARI. At the end of the summer interns write a paper about their research which is published in the annually published PARI Summer Student Proceedings. Several of the students have presented their results at AAS Meetings. We will present a summary of specific research conducted by the students with their mentors and the logistics for hosting the PARI undergraduate internship program.

Enhancing Postgraduate Learning and Teaching: Postgraduate Summer School in Dairy Science

PubMed Central

Gabai, Gianfranco; Morgante, Massimo; Gallo, Luigi

2014-01-01

Dairy science is a multidisciplinary area of scientific investigation and Ph.D. students aiming to do research in the field of animal and/or veterinary sciences must be aware of this. Ph.D. students often have vast spectra of research interests, and it is quite challenging to satisfy the expectation of all of them. The aim of this study was to establish an international Ph.D. training program based on research collaboration between the University of Sydney and the University of Padova. The core component of this program was a two-week Postgraduate Summer School in Dairy Science, which was held at the University of Padova, for Ph.D. students of both universities. Therefore, we designed a program that encompassed seminars, workshops, laboratory practical sessions, and farm visits. Participants were surveyed using a written questionnaire. Overall, participants have uniformly praised the Summer School calling it a rewarding and valuable learning experience. The Ph.D. Summer School in Dairy Science provided its participants a positive learning experience, provided them the opportunity to establish an international network, and facilitated the development of transferable skills. PMID:24575312

Out of Warburg effect: An effective cancer treatment targeting the tumor specific metabolism and dysregulated pH.

PubMed

Schwartz, Laurent; Seyfried, Thomas; Alfarouk, Khalid O; Da Veiga Moreira, Jorgelindo; Fais, Stefano

2017-04-01

As stated by Otto Warburg nearly a century ago, cancer is a metabolic disease, a fermentation caused by malfunctioning mitochondria, resulting in increased anabolism and decreased catabolism. Treatment should, therefore, aim at restoring the energy yield. To decrease anabolism, glucose uptake should be reduced (ketogenic diet). To increase catabolism, the oxidative phosphorylation should be restored. Treatment with a combination of α-lipoic acid and hydroxycitrate has been shown to be effective in multiple animal models. This treatment, in combination with conventional chemotherapy, has yielded extremely encouraging results in glioblastoma, brain metastasis and lung cancer. Randomized trials are necessary to confirm these preliminary data. The major limitation is the fact that the combination of α-lipoic acid and hydroxycitrate can only be effective if the mitochondria are still present and/or functional. That may not be the case in the most aggressive tumors. The increased intracellular alkalosis is a strong mitogenic signal, which bypasses most inhibitory signals. Concomitant correction of this alkalosis may be a very effective treatment in case of mitochondrial failure. Copyright © 2017 Elsevier Ltd. All rights reserved.

Summer Splash. 1988 Wisconsin Summer Library Program Manual. Bulletin No. 8230.

ERIC Educational Resources Information Center

Lamb, Donald K.; And Others

A compilation of materials contributed by and developed with the cooperation of Wisconsin librarians and Ohio's 1987 summer reading program, this planning manual provides guidelines for planning and promoting summer programs for young people by librarians in the state of Wisconsin. The theme of the program, "Summer Splash," is intended…

Tsunami Summer! 2003 Young Adult Summer Library Program.

ERIC Educational Resources Information Center

Alabama Public Library Service, Montgomery.

This manual is designed to assist public libraries in Alabama with setting up "Tsunami Summer!," a summer program for young adults, i.e., students in grades 6 through 12. The manual contains the following sections: (1) Publicity and Promotion; (2) Working with Schools; (3) Involving the Students, including teen volunteers, teen advisory…

Slithering into Summer

ERIC Educational Resources Information Center

Scott, Catherine; Matthews, Catherine

2012-01-01

The summer provides a unique opportunity for children to further their interests in science, especially science in the out-of-doors. Once school is out for the summer, there is seemingly unlimited time, with no strict curriculum guidelines to follow. For students with a passion for the out-of-doors, summer science camps and school-based summer…

EDITORIAL: 17th International Summer School on Vacuum, Electron, and Ion Technologies (VEIT 2011)

NASA Astrophysics Data System (ADS)

van de Sanden, M. C. M.; Dimitrova, Miglena; Ghelev, Chavdar

2012-03-01

The International Summer School on Vacuum, Electron and Ion Technologies (VEIT) has been organized biennially since 1977, when the VEIT Summer School series was launched by the Institute of Electronics, Bulgarian Academy of Sciences. The aim was to act as a forum for the exchange and dissemination of knowledge and ideas on the latest developments in electron-, ion- and plasma-assisted technologies. The organizers of the 2011 edition of the event were the Institute of Electronics, Bulgarian Academy of Sciences, Sofia, Bulgaria and the Department of Applied Physics, Eindhoven University of Technology, Eindhoven, The Netherlands. Whilst the school initially provided a meeting place for researchers mainly from Eastern and Central European countries, its importance has grown issue by issue. The school is now a major scientific event and a meeting place for young scientists from Eastern and Western Europe involved in research and development associated with high-tech industries. Many former school participants have gone on to become leading scientists in research establishments and companies throughout the world. Leading international companies, such as High Voltage Engineering, Balzers, Varian, and Hauzer have used the VEIT forum to present their products through oral presentations, poster contributions and exhibits. The School Proceedings have been published in special issues of the international journals Vacuum, Plasma Processes and Polymers and Journal of Physics: Conference Series. The Seventeenth edition of VEIT was held in the Black Sea resort of Sunny Beach, Bulgaria on 19-23 September 2011. It was attended by 96 participants from 18 countries: Belgium, Brazil, Bulgaria, Czech Republic, Denmark, France, Germany, Greece, The Netherlands, Romania, Russia, Serbia, Sweden, Switzerland, Turkey, Ukraine, UK and USA. Following the tradition of publishing the VEIT Proceedings, a selection of papers presented at the event is published in this special issue of Journal of

The Summer Undergraduate Research Internship Program at the Pisgah Astronomical Research Institute

NASA Astrophysics Data System (ADS)

Cline, J. Donald; Castelaz, M.; Whitworth, C.; Clavier, D.; Owen, L.; Barker, T.

2012-01-01

Pisgah Astronomical Research Institute (PARI) offers summer undergraduate research internships. PARI has received support for the internships from the NC Space Grant Consortium, NSF awards for public science education, private donations, private foundations, and through a collaboration with the Pisgah Astronomical Research and Education Center of the University of North Carolina - Asheville. The internship program began in 2001 with 4 students. This year 7 funded students participated in 2011. Mentors for the interns include PARI's Science, Education, and Information Technology Directors and visiting faculty who are members of the PARI Research Affiliate Faculty program. Students work with mentors on radio and optical astronomy research, electrical engineering for robotic control of instruments, software development for instrument control and software for citizen science projects, and science education by developing curricula and multimedia and teaching high school students in summer programs at PARI. At the end of the summer interns write a paper about their research which is published in the PARI Summer Student Proceedings. Several of the students have presented their results at AAS Meetings. We will present a summary of specific research conducted by the students with their mentors, the logistics for hosting the PARI undergraduate internship program, and plans for growth based on the impact of an NSF supported renovation to the Research Building on the PARI campus.

The Summer Undergraduate Research Internship Program at the Pisgah Astronomical Research Institute

NASA Astrophysics Data System (ADS)

Castelaz, Michael W.; Cline, J.; Whitworth, C.; Clavier, D.

2011-01-01

Pisgah Astronomical Research Institute (PARI) offers summer undergraduate research internships. PARI has received support for the internships from the NC Space Grant Consortium, NSF awards for public science education, private donations, private foundations, and through a collaboration with the Pisgah Astronomical Research and Education Center of the University of North Carolina - Asheville. The internship program began in 2001 with 4 students. This year 9 funded students participated in 2010. Mentors for the interns include PARI's Directors of Science, Education, and Information Technology and visiting faculty who are members of the PARI Research Affiliate Faculty program. Students work with mentors on radio and optical astronomy research, electrical engineering for robotic control of instruments, software development for instrument control and applets for citizen science projects, and science education by developing curricula and multimedia and teaching high school students in summer programs at PARI. At the end of the summer interns write a paper about their research which is published in the PARI Summer Student Proceedings. Several of the students have presented their results at AAS Meetings. We will present a summary of specific research conducted by the students with their mentors, the logistics for hosting the PARI undergraduate internship program, and plans for growth based on the impact of an NSF supported renovation to the Research Building on the PARI campus.

On A Project Work for International Students Paired with Japanese Partners in a Summer Intensive Japanese Program for Science and Technology

NASA Astrophysics Data System (ADS)

Fudano, Hiroko

A project work in which learners of a foreign language engage in a task with the native speakers is one of the effective ways to bring in ample real communication opportunities to a classroom. This scheme also gives both parties meaningful experiences for intercultural understanding. This paper reports a “Pythagoras” machine production project in which international students were paired up with Japanese students as a part of a Japanese for science and technology course in a summer intensive program. Based on the participants‧ course evaluation data, the paper also discusses the effectiveness of the project for Japanese language learning and for promoting intercultural understanding.

Summer Doldrums.

ERIC Educational Resources Information Center

Muchnick, Bruce

2002-01-01

For camp staff, factors that contribute to the summer doldrums are weather, level of general fatigue, unsatisfied expectations, sensory overload, accumulation of negative "self-talk," and an underlying sense of hurry. Strategies for overcoming summer doldrums involve novelty and stress management, and include promoting health, challenging…

Electrical properties of toad sartorius muscle fibres in summer and winter.

PubMed

Dulhunty, A F; Gage, P W

1973-05-01

1. The area and circumference of surface fibres of sartorius muscles were measured from photomicrographs of frozen sections of whole muscles, and compared with the values obtained assuming a circular cross-section. The latter assumption gave an over-estimate of the mean area of 28%, but only a 2% over-estimate of the circumference. In isolated, single fibres, the assumption gave over-estimates of 25 and 6%, of area and circumference respectively.2. The passive electrical properties of fibres were different in summer and winter. The mean internal resistivity, membrane resistance and membrane capacitance were 147 Omega.cm, 7.6 kOmega.cm(2) and 4 muF/cm(2) in summer, and 194 Omega.cm, 3.9 kOmega.cm(2) and 6.7 muF/cm(2) in winter, in fibres of comparable diameters in situ. In single fibres in summer, the mean values were 120 Omega.cm, 8.6 kOmega.cm(2) and 3.6 muF/cm(2).3. In glycerol-treated fibres the mean specific membrane capacitance was 1.0 muF/cm(2) in summer and 2.0 muF/cm(2) in winter. The internal resistivity and specific membrane resistance were 167 Omega.cm and 8.9 kOmega.cm(2) in summer, and 232 Omega.cm and 3.9 kOmega.cm(2) in winter.4. Early after-depolarizations were recorded in glycerol-treated fibres which had a low membrane capacitance, did not twitch and showed little ;creep'. Electron micrographs of glycerol-treated fibres showed disruption of the transverse tubular system and sarcoplasmic reticulum.5. After exposure of muscles to 400 mM urea or acetamide for 1 hr, muscle fibres did not twitch and had a reduced membrane capacitance in Ringer solution.

A role for the mitochondrial pyruvate carrier as a repressor of the Warburg Effect and colon cancer cell growth

PubMed Central

Schell, John C.; Olson, Kristofor A.; Jiang, Lei; Hawkins, Amy J.; Van Vranken, Jonathan G.; Xie, Jianxin; Egnatchik, Robert A.; Earl, Espen G.; Deberardinis, Ralph J.; Rutter, Jared

2014-01-01

Summary Cancer cells are typically subject to profound metabolic alterations, including the Warburg effect wherein cancer cells oxidize a decreased fraction of the pyruvate generated from glycolysis. We show herein that the mitochondrial pyruvate carrier (MPC), composed of the products of the MPC1 and MPC2 genes, modulates fractional pyruvate oxidation. MPC1 is deleted or underexpressed in multiple cancers and correlates with poor prognosis. Cancer cells re-expressing MPC1 and MPC2 display increased mitochondrial pyruvate oxidation, with no changes in cell growth in adherent culture. MPC re-expression exerted profound effects in anchorage-independent growth conditions, however, including impaired colony formation in soft agar, spheroid formation, and xenograft growth. We also observed a decrease in markers of stemness and traced the growth effects of MPC expression to the stem cell compartment. We propose that reduced MPC activity is an important aspect of cancer metabolism, perhaps through altering the maintenance and fate of stem cells. PMID:25458841

Innovation in medical education: summer studentships.

PubMed

Cleland, Jennifer; Engel, Naomi; Dunlop, Ross; Kay, Christine

2010-03-01

few doctors choose academic medicine as a career. Reasons suggested for this include a lack of exposure. Thus, we wished to broaden the opportunities available for undergraduate medical students to experience academic medicine, specifically medical education. The approach selected was to establish a programme of competitive Teaching Development Awards: the 'Summer Studentship Scheme'. this article describes the approach taken, including an overview of the organisation of the Summer Studentship Scheme, and provides preliminary data on gains from the programme. Twenty studentships were funded over a 3-year period. The projects covered a wide range of topics. Information on what the students gained from the projects and supervisor views of the programme were sought by questionnaire and self-reflective statements. the academic gains to date include nine presentations at national conferences and four published papers. All student respondents (87%) agreed that they would recommend a summer studentship to another student. Supervising a studentship (86% response rate) was seen as a positive experience. a relatively small level of funding can lead to great gains, in terms of academic output, internally, and in terms of external dissemination, as well as in gains to participating students and staff. We plan to track the career developments of participating students to see if they are more likely to pursue academic medicine as their peers. Blackwell Publishing Ltd 2010.

Summer Matters: Advocating for Summer Learning That Can Weather Political Seasons

ERIC Educational Resources Information Center

McQuade, Aaron

2015-01-01

Research has shown that an idle summer is not just boring; it can cost a student as much as two to three months of educational progress. Summer is critical to each child's development, both mind and body. Any meaningful attempts to get at America's equity divide and the consequent gap in opportunities for kids must include summer education as a…

Fireplace in former summer kitchen from west. The summer kitchen ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

Fireplace in former summer kitchen from west. The summer kitchen is now attached at the southeast elevation of the main house. - William Carmichael House, 201 East Water Street, Centreville, Queen Anne's County, MD

How predictable is the timing of a summer ice-free Arctic?

NASA Astrophysics Data System (ADS)

Jahn, Alexandra; Kay, Jennifer E.; Holland, Marika M.; Hall, David M.

2016-09-01

Climate model simulations give a large range of over 100 years for predictions of when the Arctic could first become ice free in the summer, and many studies have attempted to narrow this uncertainty range. However, given the chaotic nature of the climate system, what amount of spread in the prediction of an ice-free summer Arctic is inevitable? Based on results from large ensemble simulations with the Community Earth System Model, we show that internal variability alone leads to a prediction uncertainty of about two decades, while scenario uncertainty between the strong (Representative Concentration Pathway (RCP) 8.5) and medium (RCP4.5) forcing scenarios adds at least another 5 years. Common metrics of the past and present mean sea ice state (such as ice extent, volume, and thickness) as well as global mean temperatures do not allow a reduction of the prediction uncertainty from internal variability.

The Warburg effect in mycobacterial granulomas is dependent on the recruitment and activation of macrophages by interferon-γ

PubMed Central

Appelberg, Rui; Moreira, Diana; Barreira-Silva, Palmira; Borges, Margarida; Silva, Letícia; Dinis-Oliveira, Ricardo Jorge; Resende, Mariana; Correia-Neves, Margarida; Jordan, Michael B; Ferreira, Nuno C; Abrunhosa, Antero J; Silvestre, Ricardo

2015-01-01

Granulomas are the hallmark of mycobacterial disease. Here, we demonstrate that both the cell recruitment and the increased glucose consumption in granulomatous infiltrates during Mycobacterium avium infection are highly dependent on interferon-γ (IFN-γ). Mycobacterium avium-infected mice lacking IFN-γ signalling failed to developed significant inflammatory infiltrations and lacked the characteristic uptake of the glucose analogue fluorine-18-fluorodeoxyglucose (FDG). To assess the role of macrophages in glucose uptake we infected mice with a selective impairment of IFN-γ signalling in the macrophage lineage (MIIG mice). Although only a partial reduction of the granulomatous areas was observed in infected MIIG mice, the insensitivity of macrophages to IFN-γ reduced the accumulation of FDG. In vivo, ex vivo and in vitro assays showed that macrophage activated by IFN-γ displayed increased rates of glucose uptake and in vitro studies showed also that they had increased lactate production and increased expression of key glycolytic enzymes. Overall, our results show that the activation of macrophages by IFN-γ is responsible for the Warburg effect observed in organs infected with M. avium. PMID:25807843

Summer Astronomy

ERIC Educational Resources Information Center

Riddle, Bob

2004-01-01

This brief article describes what can be expected of the skies in the summer of 2004 with quite a few celestial thrills to anticipate. In addition to the planet viewing opportunities, there is a very rare Venus transit of the Sun and the annual Perseid meteor shower. The 2004 summer also marks both an end and beginning for the Cassini/Huygens…

Controls on summer low flow

NASA Astrophysics Data System (ADS)

Graham, C. B.; McNamara, J. P.

2012-12-01

Summer low flow has significant impacts on aquatic flora and fauna, municipal water use, and power generation. However, the controls on the minimum annual summer discharge are complex, including a combination of snowmelt dynamics, summer evapotranspiration demand, and spring, summer precipitation patterns and surface - groundwater interactions. This is especially true in the Rocky Mountain West of the United States, where snowpack provides the majority of water available for spring runoff and groundwater replenishment. In this study, we look at summer low flow conditions at four snow dominated catchments (26 km2 - 2200 km2) in South-central Idaho currently feeling the effects of climate change. Measures of snowmelt dynamics, summer evapotranspiration demand and spring and summer precipitation are used to determine the dominant controls on late summer low flow magnitude, timing and duration. These analyses show that the controls vary between watersheds, with significant implications for the impacts of climate change in snow dominated areas of the Rocky Mountain West.

Booktalking: Avoiding Summer Drift

ERIC Educational Resources Information Center

Whittingham, Jeff; Rickman, Wendy A.

2015-01-01

Summer drift, otherwise known as loss of reading comprehension skills or reading achievement, has been a well-known and well-documented phenomenon of public education for decades. Studies from the late twentieth century to the present have demonstrated a slowdown in summer drift attributed to specific summer reading programs addressing motivation…

Research summer camp in photonics

NASA Astrophysics Data System (ADS)

Buyanovskaya, Elizaveta; Melnik, Maksim; Egorov, Vladimir; Gleim, Artur; Lukishova, Svetlana; Kozlov, Sergei; Zhang, Xi-Cheng

2017-08-01

ITMO University and the University of Rochester became close partners several years ago. One of the first outcomes of this mutually beneficial partnership was the creation of International Institute of Photonics and Optical Information Technologies led by Prof. Sergei Kozlov and Prof. Xi-Cheng Zhang. Universities have created a double Masters-degree program in optics in 2014, and several ITMO students have been awarded degrees from Rochester. At the same time ITMO University organizes Summer Research camp in Photonics for University of Rochester students. Students spent two weeks in the Northern Capital of Russia learning about the emerging practical applications of femtosecond optics, terahertz biomedicine and quantum information technologies.

Patterns of Literacy Learning in German Primary Schools over the Summer and the Influence of Home Literacy Practices

ERIC Educational Resources Information Center

Meyer, Frauke; Meissel, Kane; McNaughton, Stuart

2017-01-01

The "summer learning effect" (SLE) is described as a stall or drop in achievement over summer, especially in schools serving poor or "minority" communities. There has been little research in Europe on the effect, and research internationally has primarily focused on the effect in reading, with minimal focus on writing. This…

EDITORIAL: The Fifth International Workshop and Summer School on Plasma Physics

NASA Astrophysics Data System (ADS)

2006-04-01

Plasma, the fourth state of matter, is actually the first state of Nature. The great fireball, the Sun, entirely decides the existence of our tiny planet immersed in the ocean of cosmic plasma. Mankind has also learnt how to produce and use plasma under terrestrial conditions, though it is not at all easy to domesticate this unstable ionized medium. Plasma finds countless applications that improve the quality of our daily life. Some of them, such as fluorescent light tubes, are so obvious to us that we do not give any thought to the processes underlying colourful neon signs. Another vast field is the production of materials with tailored-to-demand properties: mechanical, chemical, optical, electrical, magnetic, etc. Thin layers formed on solid surfaces by various plasma--material interactions play important roles in present-day computer technology, communication, space research, machinery and even many decorative items. However, the most demanding challenge in using plasma is to harness on Earth the processes that power stars. The endeavour is to confine and stabilize hot plasmas and to achieve the ultimate goal: to benefit from the might of thermonuclear reactions for environmentally benign energy production. The goal is clear, as the demand for energy is unquestionable. But the challenges are also enormous. Two basic plasma confinement schemes have been explored: inertial (using ultra-strong laser pulses or ion beams), and magnetic confinement (using strong magnetic fields). Hot plasma must be maintained in a vacuum vessel. The temperature gradients between the plasma and the surrounding wall are probably the greatest in the Universe. The history of fusion research began in the 1940s. Since then we have observed significant progress in fusion science and technology. We have come to the point when it has been decided to construct a reactor-class device. ITER International Thermonuclear Experimental Reactor will be built by seven co-operating parties: the EU, Japan

Comparison of total energy expenditure between school and summer months.

PubMed

Zinkel, S R J; Moe, M; Stern, E A; Hubbard, V S; Yanovski, S Z; Yanovski, J A; Schoeller, D A

2013-10-01

Childhood obesity has increased 3 to 4 fold. Some children gain excess weight in summer. Total energy expenditure increases almost linearly with fat-free mass. A lower total energy expenditure was not detected in summer. Recent data report that the youth experience greater weight gain during summer than during school months. We tested the hypothesis that a difference in total energy expenditure (TEE) between school and summer months exists and may contribute to summer weight gain. A secondary analysis was performed on cross-sectional TEE data from school-age, sedentary African-American and Caucasian youth based in or near the District of Columbia who were at-risk for adult obesity because they had body mass index (BMI) ≥ 85th percentile or had overweight parents. TEE was estimated from 18-O and deuterium measurements during 1-week intervals using urine samples collected after ingestion of doubly labelled water. Differences in summer- and school-time TEE were assessed using analysis of covariance. The data were adjusted for fat-free mass (FFM) as determined by deuterium dilution to adjust for the effect of body size on TEE. Data were collected from 162 youth (average age 10 ± 2 years, BMI 28 ± 8 kg m(-2) and BMI z-score 1.96 + 0.96). Of these, 96 youth had TEE measured during the school year (September-June); 66 different youths had TEE measured during summer months (June-August). After adjustment for FFM, average summertime TEE was 2450 ± 270 kcal d(-1) and average school-time TEE was 2510 ± 350 kcal d(-1) (P = 0.26). No difference in TEE was detected between the school year and the summer months. These data suggest that seasonal differences in youth weight gain are not necessarily due to differences in energy expenditures. © 2013 The Authors. Pediatric Obesity © 2013 International Association for the Study of Obesity.

Summertime, Summer Teens: Summer School Enrollment and the Youth Labor Force.

ERIC Educational Resources Information Center

Stringer, Tiffany

2003-01-01

Describes changes in how teenagers spend their summers and at the trends in summer school enrollment. Discusses teens' labor force participation and includes information about types of jobs, hours they work, wages, and teenage workers' rights. (JOW)

Evaluation of a Summer Reading Program to Reduce Summer Setback

ERIC Educational Resources Information Center

Johnston, Jessica; Riley, Jessica; Ryan, Carey; Kelly-Vance, Lisa

2015-01-01

Summer setback, which is defined as a decline in academic achievement over the summer months, occurs in many academic areas but seems especially problematic in reading. We assessed students from a midwestern parochial school serving predominantly students from a low--socioeconomic status background for their reading achievement before they left…

The Summer Slide: What We Know and Can Do about Summer Learning Loss

ERIC Educational Resources Information Center

Alexander, Karl, Ed.; Pitcock, Sarah, Ed.; Boulay, Matthew C., Ed.

2016-01-01

This book is an authoritative examination of summer learning loss, featuring original contributions by scholars and practitioners at the forefront of the movement to understand--and stem--the "summer slide." The contributors provide an up-to-date account of what research has to say about summer learning loss, the conditions in low-income…

Internal Dynamics and Boundary Forcing Characteristics Associated with Interannual Variability of the Asian Summer Monsoon

NASA Technical Reports Server (NTRS)

Lau, K.- M.; Kim, K.-M.; Yang, S.

1998-01-01

In this paper, we present a description of the internal dynamics and boundary forcing characteristics of two major components of the Asian summer monsoon (ASM), i.e., the South Asian (SAM) and the Southeast-East Asian monsoon (SEAM). The description is based on a new monsoon-climate paradigm in which the variability of ASM is considered as the outcome of the interplay of a "fast" and an "intermediate" monsoon subsystem, under the influenced of the "slow" varying external forcings. Two sets of regional monsoon indices derived from dynamically consistent rainfall and wind data are used in this study. For SAM, the internal dynamics is represented by that of a "classical" monsoon system where the anomalous circulation is governed by Rossby-wave dynamics, i.e., generation of anomalous vorticity induced by an off-equatorial heat source is balanced by planetary vorticity advection. On the other hand, the internal dynamics of SEAM is characterized by a "hybrid" monsoon system featuring multi-cellular meridional circulation over the East Asian section, extending from the deep tropics to midlatitudes. These meridional-cells link tropical heating to extratropical circulation system via the East Asian jetstream, and are responsible for the characteristic occurrences of zonally oriented anomalous rainfall patterns over East Asian and the subtropical western Pacific. In the extratropical regions, the major upper level vorticity balance is by anomalous vorticity advection and generation by the anomalous divergent circulation. A consequence of this is that compared to SAM, the SEAM is associated with stronger teleconnection patterns to regions outside the ASM. A strong SAM is linked to basin-scale sea surface temperature (SST) fluctuation with significant signal in the equatorial eastern Pacific. During the boreal spring SST warming in the Arabian Sea and the subtropical western Pacific may lead to a strong SAM. For SEAM, interannual variability is tied to SSTA over the Sea of

Summer library reading programs.

PubMed

Fiore, Carole D

2007-01-01

Virtually all public libraries in the United States provide some type of summer library reading program during the traditional summer vacation period. Summer library reading programs provide opportunities for students of many ages and abilities to practice their reading skills and maintain skills that are developed during the school year. Fiore summarizes some of the research in the field and relates it to library programs and usage by students. Several traditional and innovative programs from U.S. and Canadian libraries are described. She concludes with a call for further research related to summer library reading programs.

Analysis and interpretation of transcriptomic data obtained from extended Warburg effect genes in patients with clear cell renal cell carcinoma

PubMed Central

Sanders, Edward; Diehl, Svenja

2015-01-01

Background Many cancers adopt a metabolism that is characterized by the well-known Warburg effect (aerobic glycolysis). Recently, numerous attempts have been made to treat cancer by targeting one or more gene products involved in this pathway without notable success. This work outlines a transcriptomic approach to identify genes that are highly perturbed in clear cell renal cell carcinoma (CCRCC). Methods We developed a model of the extended Warburg effect and outlined the model using Cytoscape. Following this, gene expression fold changes (FCs) for tumor and adjacent normal tissue from patients with CCRCC (GSE6344) were mapped on to the network. Gene expression values with FCs of greater than two were considered as potential targets for treatment of CCRCC. Results The Cytoscape network includes glycolysis, gluconeogenesis, the pentose phosphate pathway (PPP), the TCA cycle, the serine/glycine pathway, and partial glutaminolysis and fatty acid synthesis pathways. Gene expression FCs for nine of the 10 CCRCC patients in the GSE6344 data set were consistent with a shift to aerobic glycolysis. Genes involved in glycolysis and the synthesis and transport of lactate were over-expressed, as was the gene that codes for the kinase that inhibits the conversion of pyruvate to acetyl-CoA. Interestingly, genes that code for unique proteins involved in gluconeogenesis were strongly under-expressed as was also the case for the serine/glycine pathway. These latter two results suggest that the role attributed to the M2 isoform of pyruvate kinase (PKM2), frequently the principal isoform of PK present in cancer: i.e. causing a buildup of glucose metabolites that are shunted into branch pathways for synthesis of key biomolecules, may not be operative in CCRCC. The fact that there was no increase in the expression FC of any gene in the PPP is consistent with this hypothesis. Literature protein data generally support the transcriptomic findings. Conclusions A number of key genes have

Adapting and Bending the Portal to the Public: Evaluation of an NSF-Funded Science Communication Model for UNAVCO's Geoscience Summer Internships

NASA Astrophysics Data System (ADS)

Dutilly, E.; Charlevoix, D. J.; Bartel, B. A.

2017-12-01

UNAVCO is a National Science Foundation (NSF) facility specializing in geodesy. As part of its education and outreach work, it operates annual summer internships. In 2016, UNAVCO joined the Portal to the Public (PoP) network and the PoP model was adapted and bent to provide science communication professional development for summer interns. PoP is one way that UNAVCO invests in and trains future generations of geoscientists. The NSF-funded PoP initiative and its network, PoPNet, is a premier outreach framework connecting scientists and public audiences for over a decade. PoPNet is a network of sixty organizations committed to using the PoP method to engage the public in face-to-face interactions with practicing scientists. The PoP initiative provides professional development to scientists focused on best practices in science communication, helps them to develop an interactive exhibit consistent with their current research, and offers them a venue for interacting with the public. No other evaluation work to date has examined how summer internships can uptake the PoP model. This presentation focuses on evaluation findings from two cohorts of summer interns across two years. Three primary domains were assessed: how demographic composition across cohorts required changes to the original PoP framework, which of the PoP professional development trainings were valued (or not) by interns, and changes to intern knowledge, attitudes, and abilities to communicate science. Analyses via surveys and interviews revealed that level of intern geoscience knowledge was a major factor in deciding the focus of the work, specifically whether to create new hands-on exhibits or use existing ones. Regarding the use of PoP trainings, there was no obvious pattern in what interns preferred. Most growth and learning for interns occurred during and after the outreach activity. Results of this evaluation can be used to inform other applications of the PoP approach in summer internships.

Supplemental Summer Literacy Instruction: Implications for Preventing Summer Reading Loss

ERIC Educational Resources Information Center

McDaniel, Sara C.; McLeod, Ragan; Carter, Coddy L.; Robinson, Cecil

2017-01-01

Summer reading loss is a prevalent problem that occurs primarily for students who are not exposed to or encouraged to read at home or in summer programs when school is out. This problem prevails among early readers from low-income backgrounds. This study provided 31 six and seven-year-old children with a structured guided reading program through…

Summer diapause induced by high temperatures in the oriental tobacco budworm: ecological adaptation to hot summers.

PubMed

Liu, Zhudong; Xin, Yucui; Zhang, Yanan; Fan, Jianting; Sun, Jianghua

2016-06-07

Summer diapause in Helicoverpa assulta (Hübner), which prolongs the pupal stage, particularly in males, is induced by high temperatures. In the laboratory, 3(rd)-, 4(th)-, 6(th)-instar and prepupal larvae were exposed to high temperatures - 33 and 35 °C with a photoperiod of LD16:8 - until pupation to induce summer diapause. The results showed that the incidence of summer diapause was influenced by temperature, stage exposed, and sex. The higher the temperature, the more often summer diapause was attained. Sixth-instar and prepupal larvae were the sensitive stages for summer diapause induction. H. assulta summer-diapausing pupae needed diapause development to resume development when temperatures became favorable. Furthermore, both body mass and energy storage capacity (lipid and glycogen) were significantly affected by diapause rather than sex, and were significantly higher in summer-diapausing pupae than in non-diapausing pupae. In addition, the body mass loss and respiration rate showed that the rate of metabolism in the summer-diapausing pupae was consistently lower than in non-diapausing pupae, which were significantly affected by diapause and pupal age. We conclude that summer diapause in H. assulta is a true diapause, and H. assulta has evolved mechanisms to accumulate energy storage and to lower its metabolism to adapt to hot summers.

Male and Female Summer Interns in Engineering from 2007-2012

NASA Technical Reports Server (NTRS)

Hall, Cathy W.; Brush, Kimberly M.; Pinelli, Thomas E.

2013-01-01

The purpose of this study was to ascertain the colleges and universities from which engineering interns were chosen for the Langley Aerospace Research Student Scholars (LARSS) internship program over a six year period. While the initial question was where the interns were from, information was also obtained on these colleges and universities' rankings with respect to female faculty in tenure/tenure-track positions as well as research expenditures according to the American Society for Engineering Education's (ASEE) 2012 Annual Report. The majority of interns were selected from 14 institutions. Eight of the institutions for female interns and 7 for male interns were also cited as having the largest percentages/numbers of female faculty according to ASEE data. In 10 of the 14 institutions for male interns and 9 of 14 for female interns, the institutions were cited as having some of the highest research expenditures. Last, data from ASEE's report on bachelor degrees awarded in 2011 was assessed with respect to the 21 institutions listed as having higher numbers of women in tenure/tenure-track positions. The majority of these institutions represented larger engineering programs with a sizeable number of engineering faculty. These 21institutions accounted for 24.4% of the total engineering bachelor degrees awarded in 2011, with 27.4% of all female and 23.8% of all male graduates in the U.S.

Postgraduate training for young psychiatrists--experience of the Berlin Summer School.

PubMed

Mihai, A; Ströhle, A; Maric, N; Heinz, A; Helmchen, H; Sartorius, N

2006-12-01

Growing professional exchange between Eastern and Western European countries increases the possibilities for international postgraduate training courses and by that satisfying the need for rapid and facilitation of travel and migration in the enlarged European Union increase achieving high standards. The purpose of this study was to evaluate a summer school program that trained young Eastern European psychiatrists and to assess the impact of the program on their professional development and future activities. We evaluated the training effect of the first 3 years of the Berlin Summer School with respect to (1) the participants' satisfaction with the topics, quality and originality of the presentations, and (2) long-term effects and implications for their professional career. All participants (N=43) filled out anonymously the evaluation form at the end of each summer school. An evaluation of long-term effects was carried out 2 years later with a questionnaire that was sent via e-mail to all former participants. Participants were most satisfied with practical topics such as "how to prepare a paper", "how to evaluate a paper", or "how to participate in a congress." The appreciation of the presented topics and the appreciation of courses increased in each consecutive summer school. All summer school participants reported that the course had some influence on their future career, and one fifth of the participants felt that their professional development was influenced "a lot". Although limited to 1 week of intensive training, a summer school program can have a longer lasting positive influence on the professional development of the participants. Participants felt that particularly the training of practical skills improved their research performance. Former participants founded an independent multicentric and multinational research group and supported national courses that were organized similar to the Berlin Summer School.

Summer diapause induced by high temperatures in the oriental tobacco budworm: ecological adaptation to hot summers

PubMed Central

Liu, Zhudong; Xin, Yucui; Zhang, Yanan; Fan, Jianting; Sun, Jianghua

2016-01-01

Summer diapause in Helicoverpa assulta (Hübner), which prolongs the pupal stage, particularly in males, is induced by high temperatures. In the laboratory, 3rd-, 4th-, 6th-instar and prepupal larvae were exposed to high temperatures – 33 and 35 °C with a photoperiod of LD16:8 – until pupation to induce summer diapause. The results showed that the incidence of summer diapause was influenced by temperature, stage exposed, and sex. The higher the temperature, the more often summer diapause was attained. Sixth-instar and prepupal larvae were the sensitive stages for summer diapause induction. H. assulta summer-diapausing pupae needed diapause development to resume development when temperatures became favorable. Furthermore, both body mass and energy storage capacity (lipid and glycogen) were significantly affected by diapause rather than sex, and were significantly higher in summer-diapausing pupae than in non-diapausing pupae. In addition, the body mass loss and respiration rate showed that the rate of metabolism in the summer-diapausing pupae was consistently lower than in non-diapausing pupae, which were significantly affected by diapause and pupal age. We conclude that summer diapause in H. assulta is a true diapause, and H. assulta has evolved mechanisms to accumulate energy storage and to lower its metabolism to adapt to hot summers. PMID:27271223

Bioengineering and Bioinformatics Summer Institutes: Meeting Modern Challenges in Undergraduate Summer Research

PubMed Central

Dong, Cheng; Snyder, Alan J.; Jones, A. Daniel; Sheets, Erin D.

2008-01-01

Summer undergraduate research programs in science and engineering facilitate research progress for faculty and provide a close-ended research experience for students, which can prepare them for careers in industry, medicine, and academia. However, ensuring these outcomes is a challenge when the students arrive ill-prepared for substantive research or if projects are ill-defined or impractical for a typical 10-wk summer. We describe how the new Bioengineering and Bioinformatics Summer Institutes (BBSI), developed in response to a call for proposals by the National Institutes of Health (NIH) and the National Science Foundation (NSF), provide an impetus for the enhancement of traditional undergraduate research experiences with intense didactic training in particular skills and technologies. Such didactic components provide highly focused and qualified students for summer research with the goal of ensuring increased student satisfaction with research and mentor satisfaction with student productivity. As an example, we focus on our experiences with the Penn State Biomaterials and Bionanotechnology Summer Institute (PSU-BBSI), which trains undergraduates in core technologies in surface characterization, computational modeling, cell biology, and fabrication to prepare them for student-centered research projects in the role of materials in guiding cell biology. PMID:18316807

The Anti-Warburg Effect Elicited by the cAMP-PGC1α Pathway Drives Differentiation of Glioblastoma Cells into Astrocytes.

PubMed

Xing, Fan; Luan, Yizhao; Cai, Jing; Wu, Sihan; Mai, Jialuo; Gu, Jiayu; Zhang, Haipeng; Li, Kai; Lin, Yuan; Xiao, Xiao; Liang, Jiankai; Li, Yuan; Chen, Wenli; Tan, Yaqian; Sheng, Longxiang; Lu, Bingzheng; Lu, Wanjun; Gao, Mingshi; Qiu, Pengxin; Su, Xingwen; Yin, Wei; Hu, Jun; Chen, Zhongping; Sai, Ke; Wang, Jing; Chen, Furong; Chen, Yinsheng; Zhu, Shida; Liu, Dongbing; Cheng, Shiyuan; Xie, Zhi; Zhu, Wenbo; Yan, Guangmei

2017-01-10

Glioblastoma multiforme (GBM) is among the most aggressive of human cancers. Although differentiation therapy has been proposed as a potential approach to treat GBM, the mechanisms of induced differentiation remain poorly defined. Here, we established an induced differentiation model of GBM using cAMP activators that specifically directed GBM differentiation into astroglia. Transcriptomic and proteomic analyses revealed that oxidative phosphorylation and mitochondrial biogenesis are involved in induced differentiation of GBM. Dibutyryl cyclic AMP (dbcAMP) reverses the Warburg effect, as evidenced by increased oxygen consumption and reduced lactate production. Mitochondrial biogenesis induced by activation of the CREB-PGC1α pathway triggers metabolic shift and differentiation. Blocking mitochondrial biogenesis using mdivi1 or by silencing PGC1α abrogates differentiation; conversely, overexpression of PGC1α elicits differentiation. In GBM xenograft models and patient-derived GBM samples, cAMP activators also induce tumor growth inhibition and differentiation. Our data show that mitochondrial biogenesis and metabolic switch to oxidative phosphorylation drive the differentiation of tumor cells. Copyright © 2017 The Authors. Published by Elsevier Inc. All rights reserved.

You're Doing "What" This Summer? Making the Most of International Professional Development

ERIC Educational Resources Information Center

Patterson, Timothy

2014-01-01

The content of social studies curricula make studying abroad during the summer months a win-win for social studies teachers. During these experiences, teachers have the opportunity to develop their knowledge of global history and other cultures and to see a bit of the world. That said, the most dangerous assumption one can make is that simply…

2010 Summer Transportation Institute

DOT National Transportation Integrated Search

2012-09-01

The Summer Transportation Institute (STI) hosted by the Western Transportation Institute at Montana : State University serves to attract high school students to participate in an innovative summer : educational program in transportation. The STI aims...

2010 Summer Transportation Institute

DOT National Transportation Integrated Search

2010-09-01

The Summer Transportation Institute (STI) hosted by the Western Transportation Institute at Montana : State University serves to attract high school students to participate in an innovative summer : educational program in transportation. The STI aims...

Summer Enrichment Workshop (SEW): A Quality Component of the University of Alabama's Gifted Education Preservice Training Program

ERIC Educational Resources Information Center

Newman, Jane L.; Gregg, Madeleine; Dantzler, John

2009-01-01

Summer Enrichment Workshop (SEW) is a clinical experience in the teacher preservice training program for gifted and talented (GT) master's degree interns at the University of Alabama. This mixed design study investigated the effects of the SEW clinical experience on interns' preparation to teach. Quantitative analysis demonstrated a statistically…

Influence of the Summer NAO on the Spring-NAO-Based Predictability of the East Asian Summer Monsoon

NASA Astrophysics Data System (ADS)

Zheng, Fei

2017-04-01

The dominant mode of atmospheric circulation over the North Atlantic region is the North Atlantic Oscillation (NAO). The boreal spring NAO may imprint its signal on contemporaneous sea surface temperature (SST), leading to a North Atlantic SST tripolar pattern (NAST). This pattern persists into the following summer and modulates the East Asian summer monsoon (EASM). Previous studies have shown that the summer NAST is caused mainly by the preceding spring NAO, whereas the contemporaneous summer NAO plays a secondary role. The results of this study illustrate that, even if the summer NAO plays a secondary role, it may also perturb summer SST anomalies caused by the spring NAO. There are two types of perturbation caused by the summer NAO. If the spring and summer NAO patterns have the same (opposite) polarities, the summer NAST tends to be enhanced (reduced) by the summer NAO, and the correlation between the spring NAO and EASM is usually stronger (weaker). In the former (latter) case, the spring-NAO-based prediction of the EASM tends to have better (limited) skill. These results indicate that it is important to consider the evolution of the NAO when forecasting the EASM, particular when there is a clear reversal in the polarity of the NAO, because it may impair the spring-NAO-based EASM prediction.

Summer Learning: Accelerating Student Success

ERIC Educational Resources Information Center

Pitcock, Sarah; Seidel, Bob

2015-01-01

As numerous studies from 1906 on have confirmed, children lose ground in learning if they lack opportunities for building skills over the summer. Nonetheless, summer learning loss comes up but rarely in the national discussion of education reform. By the end of summer, students perform on average one month behind where they left off in the spring.…

Effects of summer school participation and psychosocial outcomes on changes in body composition and physical fitness during summer break.

PubMed

Park, Kyung-Shin; Lee, Man-Gyoon

2015-06-01

Evidence suggests that adolescents gain more weight during the summer break than they do during the school year, and that participation in the summer school program is beneficial in maintaining their healthy lifestyle. It is known that obesity and physical fitness in adolescents can be affected by their socio-economic and psychological status, especially during a long school break. The purpose of this study was to examine the effects of summer school participation and psychosocial outcomes on changes in body composition and physical fitness in underprivileged adolescents during the summer break. Body composition and physical fitness in 138 underprivileged adolescents were measured at the beginning and end of the summer break. A survey on socio-economic and psychological status was conducted at the beginning of the summer break. Two-way repeated measures ANOVA and Tukey post hoc tests were used for data analysis. Pearson correlation analysis was performed to establish a relation between psychological outcomes and changes in body composition and physical fitness during the summer break. Significant increases in body weight (p = .003) and % body fat (p = .014) as well as a decrease in VO2max (p = .018) were found in summer school non-attendants during the summer whereas no significant changes were found in summer school attendants. Summer school non-attendants with lower psychosocial outcomes had a greater decline in physical fitness and weight gain; however, summer school attendants were not affected by psychosocial outcomes. The summer school program effectively prevented summer weight gain among underprivileged adolescents due to the structured environment, restricted food access, and scheduled time for exercise in addition to minimizing the effects of their psychosocial outcomes. Results indicated that summer school non-attendants may require comprehensive intervention for psychosocial outcomes and nutritional education to maintain body weight and physical fitness

Effects of summer school participation and psychosocial outcomes on changes in body composition and physical fitness during summer break

PubMed Central

Park, Kyung-Shin; Lee, Man-Gyoon

2015-01-01

[Purpose] Evidence suggests that adolescents gain more weight during the summer break than they do during the school year, and that participation in the summer school program is beneficial in maintaining their healthy lifestyle. It is known that obesity and physical fitness in adolescents can be affected by their socio-economic and psychological status, especially during a long school break. The purpose of this study was to examine the effects of summer school participation and psychosocial outcomes on changes in body composition and physical fitness in underprivileged adolescents during the summer break. [Methods] Body composition and physical fitness in 138 underprivileged adolescents were measured at the beginning and end of the summer break. A survey on socio-economic and psychological status was conducted at the beginning of the summer break. Two-way repeated measures ANOVA and Tukey post hoc tests were used for data analysis. Pearson correlation analysis was performed to establish a relation between psychological outcomes and changes in body composition and physical fitness during the summer break. [Results] Significant increases in body weight (p = .003) and % body fat (p = .014) as well as a decrease in VO2max (p = .018) were found in summer school non-attendants during the summer whereas no significant changes were found in summer school attendants. Summer school non-attendants with lower psychosocial outcomes had a greater decline in physical fitness and weight gain; however, summer school attendants were not affected by psychosocial outcomes. The summer school program effectively prevented summer weight gain among underprivileged adolescents due to the structured environment, restricted food access, and scheduled time for exercise in addition to minimizing the effects of their psychosocial outcomes. [Conclusion] Results indicated that summer school non-attendants may require comprehensive intervention for psychosocial outcomes and nutritional education

Influence of Western Tibetan Plateau Summer Snow Cover on East Asian Summer Rainfall

NASA Astrophysics Data System (ADS)

Wang, Zhibiao; Wu, Renguang; Chen, Shangfeng; Huang, Gang; Liu, Ge; Zhu, Lihua

2018-03-01

The influence of boreal winter-spring eastern Tibetan Plateau snow anomalies on the East Asian summer rainfall variability has been the focus of previous studies. The present study documents the impacts of boreal summer western and southern Tibetan Plateau snow cover anomalies on summer rainfall over East Asia. Analysis shows that more snow cover in the western and southern Tibetan Plateau induces anomalous cooling in the overlying atmospheric column. The induced atmospheric circulation changes are different corresponding to more snow cover in the western and southern Tibetan Plateau. The atmospheric circulation changes accompanying the western Plateau snow cover anomalies are more obvious over the midlatitude Asia, whereas those corresponding to the southern Plateau snow cover anomalies are more prominent over the tropics. As such, the western and southern Tibetan Plateau snow cover anomalies influence the East Asian summer circulation and precipitation through different pathways. Nevertheless, the East Asian summer circulation and precipitation anomalies induced by the western and southern Plateau snow cover anomalies tend to display similar distribution so that they are more pronounced when the western and southern Plateau snow cover anomalies work in coherence. Analysis indicates that the summer snow cover anomalies over the Tibetan Plateau may be related to late spring snow anomalies due to the persistence. The late spring snow anomalies are related to an obvious wave train originating from the western North Atlantic that may be partly associated with sea surface temperature anomalies in the North Atlantic Ocean.

The ECVP/ESVP summer school in veterinary pathology: high-standard, structured training for young veterinary pathologists.

PubMed

Kipar, Anja; Aleksandersen, Mona; Benazzi, Cinzia; Hodge, Thomas; Sukura, Antti; Wyers, Monique

2007-01-01

This article describes the ECVP/ESVP Summer School in Veterinary Pathology, a new annual two-week European training facility established by the European College of Veterinary Pathologists (ECVP) in collaboration with the European Society of Veterinary Pathology (ESVP). The aim of the Summer Schools is to provide Europe-wide, harmonized, top-standard theoretical and practical post-graduate training for veterinarians specializing in veterinary pathology. In particular, it aims to support trainees in veterinary pathology in their individual preparation for the ECVP certifying examination. Ultimately, it aims to provide young pathologists with the skills and knowledge necessary to participate in international, high-quality research and the tools for applying international standards to their own research and for independent study for the ECVP certifying examination, even if they do not work in comparable academic environments and do not have the same level of local support and training. The ECVP/ESVP Summer Schools take place in European countries, with local organization from a university department of veterinary pathology. Each event comprises modules provided by internationally recognized specialists in their specific fields of expertise on different organ systems, diseases of specific species, specific techniques, and specific topics relevant to pathology, forming a cycle of four events to cover all major topics. Every two years a mock exam is organized as a tool to monitor individual progress in preparing for the ECVP certifying examination.

MARK TWAIN SUMMER INSTITUTE, 1965 SESSION. GENERAL CATALOGUE OF INFORMATION AND COURSES OFFERED.

ERIC Educational Resources Information Center

LEMEN, ROBERT F.

THE MARK TWAIN SUMMER INSTITUTE OFFERED CHALLENGING EDUCATIONAL OPPORTUNITIES, PROVIDED EXCELLENT TEACHERS AN OPPORTUNITY TO DEVELOP NEW TECHNIQUES, AND OFFERED AN "INTERN-TEACHER" PROGRAM. THE STUDENTS QUALIFIED TO ATTEND WERE ABLE SECONDARY STUDENTS FROM GRADES 9 THROUGH 12. EACH STUDENT WOULD TAKE ONE NON-CREDIT HIGH SCHOOL COURSE.…

2009 summer transportation institute.

DOT National Transportation Integrated Search

2010-01-01

Missouri LTAP at Missouri S&T has hosted a USDOT Summer Transportation Institute (STI) for the past several years. The program : has been very successful and was again offered in Summer 2009. The STI is a 2-week intensive learning experience held dur...

Summer Boost: Challenges and Opportunities in Summer Programs for Rising Kindergarten Students

ERIC Educational Resources Information Center

Condliffe, Barbara; Foster, Anna; Jacob, Robin

2017-01-01

There is a growing belief that access to academic opportunities during the summer can help close the achievement gap between low-income students and their higher-income peers. But while significant research is emerging on summer programs for school-age children, information on the preschool period is limited. The Expanding Children's Early…

Predicting the Extent of Summer Sea Ice in the Arctic

NASA Astrophysics Data System (ADS)

Rigor, I. G.; Wallace, J. M.

2003-12-01

The summers of 1998 and 2002 had the least sea ice extent (SIE) in the Arctic. These observations seem to agree with the trends noted by Parkinson, et al. (1999, hereafter P99) for the period 1979-1997, but the spatial pattern of these recent decreases in summer SIE were different. The summer trends shown by P99, exhibit large decreases in SIE primarily in the East Siberian Sea (ESS), while the decreases observed during 1998 and 2002 were much larger in the Beaufort and Chukchi seas (BCS). We now show that the trends for the period 1979 - 2002 are much smaller in the ESS than the trends shown by P99, and the largest decreasing trends have shifted from the ESS to the BCS. Rigor, et al. (2002) showed that the changes in SIE that P99 noted were driven by changes in atmospheric circulation related to the phase of the prior winter Arctic Oscillation (AO, Thompson and Wallace, 1998) index. Given that the latest trends in SIE are different than those shown by P99, one could ask whether the affect of the AO on sea ice noted by Rigor, et al. (2002) has also changed, and whether some large scale climate modes other than the AO has influenced the climate of the Arctic Ocean more? To answer these questions, we applied Empirical Orthogonal Function (EOF) analysis on the September SIE data from microwave satellites, and found that the first two modes SIE were most highly correlated to the prior winter AO, and the AO index of the summer months just prior to each September. These modes explain more than 45% of the variance in SIE, and show that the influence of the winter and summer AO dominates Arctic climate from 1979 - 2002. Using data from the International Arctic Buoy Programme and the National Centers for Environmental Prediction, we will show that the changes in sea ice extent are primarily driven by dynamic changes in sea ice thickness and discuss the implications for predicting summer SIE.

Summer U.S. Surface Air Temperature Variability: Controlling Factors and AMIP Simulation Biases

NASA Astrophysics Data System (ADS)

Merrifield, A.; Xie, S. P.

2016-02-01

This study documents and investigates biases in simulating summer surface air temperature (SAT) variability over the continental U.S. in the Coupled Model Intercomparison Project (CMIP5) Atmospheric Model Intercomparison Project (AMIP). Empirical orthogonal function (EOF) and multivariate regression analyses are used to assess the relative importance of circulation and the land surface feedback at setting summer SAT over a 30-year period (1979-2008). In observations, regions of high SAT variability are closely associated with midtropospheric highs and subsidence, consistent with adiabatic theory (Meehl and Tebaldi 2004, Lau and Nath 2012). Preliminary analysis shows the majority of the AMIP models feature high SAT variability over the central U.S., displaced south and/or west of observed centers of action (COAs). SAT COAs in models tend to be concomitant with regions of high sensible heat flux variability, suggesting an excessive land surface feedback in these models modulate U.S. summer SAT. Additionally, tropical sea surface temperatures (SSTs) play a role in forcing the leading EOF mode for summer SAT, in concert with internal atmospheric variability. There is evidence that models respond to different SST patterns than observed. Addressing issues with the bulk land surface feedback and the SST-forced component of atmospheric variability may be key to improving model skill in simulating summer SAT variability over the U.S.

A mission design for International Manned Mars Mission - From the 1991 International Space University (ISU) Design Project

NASA Technical Reports Server (NTRS)

Mendell, Wendell W.

1991-01-01

The International Space University (ISU) conducted a study of an international program to support human exploration of Mars as its annual Design Project activity during its 1991 summer session in Toulouse, France. Although an ISU Design Project strives to produce an in-depth analysis during the intense 10-week summer session, the International Mars Mission (IMM) project was conducted in a manner designed to provide a learning experience for young professionals working in an unusual multidisciplinary and multinational environment. The breadth of the IMM study exceeds that of most Mars mission studies of the past, encompassing political organization for long-term commitment, multinational management structure, cost analysis, mission architecture, vehicle configuration, crew health, life support, Mars surface infrastructure, mission operations, technology evaluation, risk assessment, scientific planning, exploration, communication networks, and Martian resource utilization. The IMM Final Report has particular value for those seeking insight into the choices made by a multinational group working in an apolitical environment on the problems of international cooperation in space.

Changes in Extremely Hot Summers over the Global Land Area under Various Warming Targets.

PubMed

Wang, Lei; Huang, Jianbin; Luo, Yong; Yao, Yao; Zhao, Zongci

2015-01-01

Summer temperature extremes over the global land area were investigated by comparing 26 models of the fifth phase of the Coupled Model Intercomparison Project (CMIP5) with observations from the Goddard Institute for Space Studies (GISS) and the Climate Research Unit (CRU). Monthly data of the observations and models were averaged for each season, and statistics were calculated for individual models before averaging them to obtain ensemble means. The summers with temperature anomalies (relative to 1951-1980) exceeding 3σ (σ is based on the local internal variability) are defined as "extremely hot". The models well reproduced the statistical characteristics evolution, and partly captured the spatial distributions of historical summer temperature extremes. If the global mean temperature increases 2°C relative to the pre-industrial level, "extremely hot" summers are projected to occur over nearly 40% of the land area (multi-model ensemble mean projection). Summers that exceed 5σ warming are projected to occur over approximately 10% of the global land area, which were rarely observed during the reference period. Scenarios reaching warming levels of 3°C to 5°C were also analyzed. After exceeding the 5°C warming target, "extremely hot" summers are projected to occur throughout the entire global land area, and summers that exceed 5σ warming would become common over 70% of the land area. In addition, the areas affected by "extremely hot" summers are expected to rapidly expand by more than 25%/°C as the global mean temperature increases by up to 3°C before slowing to less than 16%/°C as the temperature continues to increase by more than 3°C. The area that experiences summers with warming of 5σ or more above the warming target of 2°C is likely to maintain rapid expansion of greater than 17%/°C. To reduce the impacts and damage from severely hot summers, the global mean temperature increase should remain low.

Changes in Extremely Hot Summers over the Global Land Area under Various Warming Targets

PubMed Central

Wang, Lei; Huang, Jianbin; Luo, Yong; Yao, Yao; Zhao, Zongci

2015-01-01

Summer temperature extremes over the global land area were investigated by comparing 26 models of the fifth phase of the Coupled Model Intercomparison Project (CMIP5) with observations from the Goddard Institute for Space Studies (GISS) and the Climate Research Unit (CRU). Monthly data of the observations and models were averaged for each season, and statistics were calculated for individual models before averaging them to obtain ensemble means. The summers with temperature anomalies (relative to 1951–1980) exceeding 3σ (σ is based on the local internal variability) are defined as “extremely hot”. The models well reproduced the statistical characteristics evolution, and partly captured the spatial distributions of historical summer temperature extremes. If the global mean temperature increases 2°C relative to the pre-industrial level, “extremely hot” summers are projected to occur over nearly 40% of the land area (multi-model ensemble mean projection). Summers that exceed 5σ warming are projected to occur over approximately 10% of the global land area, which were rarely observed during the reference period. Scenarios reaching warming levels of 3°C to 5°C were also analyzed. After exceeding the 5°C warming target, “extremely hot” summers are projected to occur throughout the entire global land area, and summers that exceed 5σ warming would become common over 70% of the land area. In addition, the areas affected by “extremely hot” summers are expected to rapidly expand by more than 25%/°C as the global mean temperature increases by up to 3°C before slowing to less than 16%/°C as the temperature continues to increase by more than 3°C. The area that experiences summers with warming of 5σ or more above the warming target of 2°C is likely to maintain rapid expansion of greater than 17%/°C. To reduce the impacts and damage from severely hot summers, the global mean temperature increase should remain low. PMID:26090931

The State of the Summer: a Review of Child Summer Weight Gain and Efforts to Prevent It.

PubMed

Tanskey, Lindsay A; Goldberg, Jeanne; Chui, Kenneth; Must, Aviva; Sacheck, Jennifer

2018-06-01

Accumulating evidence shows that children in the USA gain weight more rapidly during the summer, when school is not in session. This narrative review spanning 2007 to 2017 summarizes efforts to characterize the problem, identify key determinants, and intervene to prevent excess summer weight gain. Summer weight gain remains a concern for elementary-age youth. Few studies have examined its determinants, but unfavorable summertime shifts in diet, physical activity, sedentary time, screen media use, and sleep have been reported. Increased structure is thought to protect against summer weight gain. Interventions to support physical activity and nutrition during the summer show promise, though large-scale impact on weight outcomes remains to be seen. Supporting health behaviors during the summer remains a priority for obesity prevention researchers, practitioners, and policymakers. Strategies to expand access to structured programs and reach beyond such programs to improve behaviors at home are of particular importance.

Evaluation of Drinks Contribution to Energy Intake in Summer and Winter

PubMed Central

Malisova, Olga; Bountziouka, Vassiliki; Zampelas, Antonis; Kapsokefalou, Maria

2015-01-01

All drinks hydrate and most also provide nutrients and energy. Our objective was to evaluate the contribution of drinks to total energy intake in summer and winter. Data were obtained using the Water Balance Questionnaire (WBQ) from a sample of the general population in Athens, Greece (n = 984), 473 individuals (42 ± 18 years) in summer and 511 individuals (38 ± 20 years) in winter stratified by sex and age. The WBQ embeds a semi-quantitative food frequency questionnaire of 58 foods and the Short International Physical Activity Questionnaire. Data were analyzed for the contribution of drinks to total energy intake. In winter, total energy intake was 2082 ± 892 kcal/day; energy intake from drinks was 479 ± 286 kcal/day and energy expenditure 1860 ± 390 kcal/day. In summer, total energy intake was 1890 ± 894 kcal/day, energy intake from drinks 492 ± 499 kcal/day and energy expenditure 1830 ± 491 kcal/day. Energy intake from drinks in summer was higher than in winter (p < 0.001) and in men higher than in women in both seasons (p < 0.001 in summer, p = 0.02 in winter). Coffee, coffee drinks, milk, chocolate milk and alcoholic drinks contributed approximately 75% of energy from drinks. Fruit juice and sugar-sweetened drinks, including soft drinks and fruit juice based drinks, were consumed less frequently contributing up to 25% of drink energy intake. Drinks contribute approximately 1/4 of total energy intake depending on the energy content of the drink and frequency of consumption. Coffee, dairy and alcoholic drinks were the main energy contributors. PMID:25988765

Evaluation of drinks contribution to energy intake in summer and winter.

PubMed

Malisova, Olga; Bountziouka, Vassiliki; Zampelas, Antonis; Kapsokefalou, Maria

2015-05-15

All drinks hydrate and most also provide nutrients and energy. Our objective was to evaluate the contribution of drinks to total energy intake in summer and winter. Data were obtained using the Water Balance Questionnaire (WBQ) from a sample of the general population in Athens, Greece (n = 984), 473 individuals (42 ± 18 years) in summer and 511 individuals (38 ± 20 years) in winter stratified by sex and age. The WBQ embeds a semi-quantitative food frequency questionnaire of 58 foods and the Short International Physical Activity Questionnaire. Data were analyzed for the contribution of drinks to total energy intake. In winter, total energy intake was 2082 ± 892 kcal/day; energy intake from drinks was 479 ± 286 kcal/day and energy expenditure 1860 ± 390 kcal/day. In summer, total energy intake was 1890 ± 894 kcal/day, energy intake from drinks 492 ± 499 kcal/day and energy expenditure 1830 ± 491 kcal/day. Energy intake from drinks in summer was higher than in winter (p < 0.001) and in men higher than in women in both seasons (p < 0.001 in summer, p = 0.02 in winter). Coffee, coffee drinks, milk, chocolate milk and alcoholic drinks contributed approximately 75% of energy from drinks. Fruit juice and sugar-sweetened drinks, including soft drinks and fruit juice based drinks, were consumed less frequently contributing up to 25% of drink energy intake. Drinks contribute approximately 1/4 of total energy intake depending on the energy content of the drink and frequency of consumption. Coffee, dairy and alcoholic drinks were the main energy contributors.

Your Best Summer Ever

ERIC Educational Resources Information Center

Cleaver, Samantha

2012-01-01

"It must be nice to have summers off." Only other teachers know just how short summer is, with much of August devoted to planning for the new school year. This article offers 17 fresh ideas for exploring, making money, and preparing for next year. Plus, a reading list that hits all the marks!

Everyday Electrical Engineering: A One-Week Summer Academy Course for High School Students

ERIC Educational Resources Information Center

Mehrizi-Sani, A.

2012-01-01

A summer academy is held for grade 9-12 high school students at the University of Toronto, Toronto, ON, Canada, every year. The academy, dubbed the Da Vinci Engineering Enrichment Program (DEEP), is a diverse program that aims to attract domestic and international high school students to engineering and sciences (and possibly recruit them). DEEP…

Book Your Summer Vacation

ERIC Educational Resources Information Center

Texley, Juliana

2012-01-01

Summer's the time for teachers to travel, not only physically from the confines of the classroom to exotic places, but vicariously, through the magic of books. Summer adventures help teachers expand their experience and enrich their store of context so that they can offer their students more when school resumes in the fall. That's why each year…

School Construction Summer Slam

ERIC Educational Resources Information Center

Jensen, Richard F.

2012-01-01

Every school has a list of renovations, upgrades and repairs that need attention, but many are too distracting and disruptive to carry out during the school year. Often, the best time to address these nagging construction projects is during the summer when students are on break and the campus is quieter. Although these "summer slammers" often are…

Emergency Immigration Education Act Programs. Summer ESL Welcome Program for Students of Limited English Proficiency, Summer Bilingual Program, Projects Omega, Wise, and Bell. Summer 1994. OER Report.

ERIC Educational Resources Information Center

Roman, Elliott M.

The Emergency Immigration Education Act supported three distinct programs in New York City in the summer of 1994: (1) the Summer English as a Second Language (ESL) Welcome Program for Students of Limited English Proficiency; (2) the Summer Bilingual Program; and (3) Projects Omega, Wise, and Bell. The projects served 3,443 students in all. The…

Center for Adaptive Optics | AO Summer School

Science.gov Websites

School on Adaptive Optics Sponsored by: Center for Adaptive Optics The AO Summer School instruction is Adaptive Optics and their implementation. Our Summer School is intended to facilitate and encourage previous summer school web pages. Please contact us, if you would like more information on AO Summer School

Start a Summer Arts Program.

ERIC Educational Resources Information Center

Pedersen, Kirie

1984-01-01

Tips on organizing a creative teaching experience for summer vacation time are offered. Program organization, student selection, course content, publicity, and funding are aspects to be considered when planning a summer arts program. (DF)

2010 Montana Summer Transportation Institute.

DOT National Transportation Integrated Search

2010-09-01

The Summer Transportation Institute (STI) hosted by the Western Transportation Institute at Montana : State University serves to attract high school students to participate in an innovative summer : educational program in transportation. The STI aims...

2011 Montana Summer Transportation Institute.

DOT National Transportation Integrated Search

2011-09-01

The Summer Transportation Institute (STI) hosted by the Western Transportation Institute at Montana State University serves to attract high school students to participate in an innovative summer educational program in transportation. The STI aims to ...

46 CFR 45.53 - Summer freeboard.

Code of Federal Regulations, 2012 CFR

2012-10-01

... 46 Shipping 2 2012-10-01 2012-10-01 false Summer freeboard. 45.53 Section 45.53 Shipping COAST... Summer freeboard. (a) Except as required in paragraph (c) of this section, the minimum freeboard in summer for a type A vessel is F in the following formula modified by the corrections in this subpart: F...

46 CFR 45.53 - Summer freeboard.

Code of Federal Regulations, 2013 CFR

2013-10-01

... 46 Shipping 2 2013-10-01 2013-10-01 false Summer freeboard. 45.53 Section 45.53 Shipping COAST... Summer freeboard. (a) Except as required in paragraph (c) of this section, the minimum freeboard in summer for a type A vessel is F in the following formula modified by the corrections in this subpart: F...

Summer Reading Lists: Research and Recommendations

ERIC Educational Resources Information Center

Lindley, Sarah; Giles, Rebecca M.; Tunks, Karyn

2016-01-01

Decades of research have focused on the impact of summer learning loss and effective tools in stemming the flow of knowledge lost during summer break. While reading lists have become a standard practice for addressing students' needs to maintain learning levels over the summer months, very little research has been conducted on the book lists…

46 CFR 45.53 - Summer freeboard.

Code of Federal Regulations, 2014 CFR

2014-10-01

... 46 Shipping 2 2014-10-01 2014-10-01 false Summer freeboard. 45.53 Section 45.53 Shipping COAST... Summer freeboard. (a) Except as required in paragraph (c) of this section, the minimum freeboard in summer for a type A vessel is F in the following formula modified by the corrections in this subpart: F...

Evaluation of the Impact of NCI Summer Curriculum on Cancer Prevention’s on Participants from Low- and Middle Income Countries

PubMed Central

Williams, Makeda J.; Otero, Isabel V.; Harford, Joe B.

2013-01-01

The NCI Summer Curriculum on Cancer Prevention provides scientists and health care professionals training in principles and practices of cancer prevention and control, and molecular biology and genetics of cancer. Originally intended for U.S. scientists, the Curriculum’s enrollment of international scientists has increased steadily. The objective of the current study was to evaluate the Curriculum’s impact on knowledge, skills and career accomplishments of the international participants from low- and middle-income countries (LMIC). International participants from 1998 to 2009 completed questionnaires regarding knowledge, overall experience and accomplishments directly associated with the Curriculum. Almost all respondents agreed the Curriculum enhanced their knowledge and skills, prepared them to contribute to cancer control activities in their home countries and addressed specific needs and achieve research goals. The NCI Summer Curriculum on Cancer Prevention gives international participants a unique opportunity to enhance their knowledge and effectively contribute to cancer control activities in their home country. PMID:23355281

46 CFR 42.30-25 - Summer Zones.

Code of Federal Regulations, 2012 CFR

2012-10-01

... 46 Shipping 2 2012-10-01 2012-10-01 false Summer Zones. 42.30-25 Section 42.30-25 Shipping COAST..., Areas, and Seasonal Periods § 42.30-25 Summer Zones. (a) The remaining areas constitute the Summer Zones... periods: Winter: November 1 to March 31. Summer: April 1 to October 31. [CGFR 68-60, 33 FR 10069, July 12...

46 CFR 42.30-25 - Summer Zones.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 46 Shipping 2 2010-10-01 2010-10-01 false Summer Zones. 42.30-25 Section 42.30-25 Shipping COAST..., Areas, and Seasonal Periods § 42.30-25 Summer Zones. (a) The remaining areas constitute the Summer Zones... periods: Winter: November 1 to March 31. Summer: April 1 to October 31. [CGFR 68-60, 33 FR 10069, July 12...

46 CFR 42.30-25 - Summer Zones.

Code of Federal Regulations, 2011 CFR

2011-10-01

... 46 Shipping 2 2011-10-01 2011-10-01 false Summer Zones. 42.30-25 Section 42.30-25 Shipping COAST..., Areas, and Seasonal Periods § 42.30-25 Summer Zones. (a) The remaining areas constitute the Summer Zones... periods: Winter: November 1 to March 31. Summer: April 1 to October 31. [CGFR 68-60, 33 FR 10069, July 12...

46 CFR 42.30-25 - Summer Zones.

Code of Federal Regulations, 2013 CFR

2013-10-01

... 46 Shipping 2 2013-10-01 2013-10-01 false Summer Zones. 42.30-25 Section 42.30-25 Shipping COAST..., Areas, and Seasonal Periods § 42.30-25 Summer Zones. (a) The remaining areas constitute the Summer Zones... periods: Winter: November 1 to March 31. Summer: April 1 to October 31. [CGFR 68-60, 33 FR 10069, July 12...

46 CFR 42.30-25 - Summer Zones.

Code of Federal Regulations, 2014 CFR

2014-10-01

... 46 Shipping 2 2014-10-01 2014-10-01 false Summer Zones. 42.30-25 Section 42.30-25 Shipping COAST..., Areas, and Seasonal Periods § 42.30-25 Summer Zones. (a) The remaining areas constitute the Summer Zones... periods: Winter: November 1 to March 31. Summer: April 1 to October 31. [CGFR 68-60, 33 FR 10069, July 12...

Celebrate Summer with Reading

ERIC Educational Resources Information Center

Texley, Juliana

2007-01-01

School is out and the summer is full of both official and unofficial holidays that prompt us to enjoy science and the profession of sharing it. As in past years, the reviewers and editors of "NSTA Recommends"--ready and willing to share their enthusiasm for reading with you--have been gathering suggestions for the summer. So along with your beach…

NREL Summer Interns Climb to New Heights | News | NREL

Science.gov Websites

, Technology, Engineering, and Math teacher interns; six National Science Foundation and U.S. Department of , said, "As a kid, I loved making and taking things apart. I was best at science and math in school

Summer Institute at Indiana U. Uses Immersion to Teach Hard-to-Learn East Asian Languages.

ERIC Educational Resources Information Center

Oberlander, Susan

1989-01-01

As East Asian countries continue to develop into major powers in the economic world, students come to Indiana University's East Asian Summer Language Institute to improve their chances for careers in those countries in international law, teaching, and business. Advice on proper etiquette is also included. (MLW)

Challenges in predicting and simulating summer rainfall in the eastern China

NASA Astrophysics Data System (ADS)

Liang, Ping; Hu, Zeng-Zhen; Liu, Yunyun; Yuan, Xing; Li, Xiaofan; Jiang, Xingwen

2018-05-01

To demonstrate the challenge of summer rainfall prediction and simulation in the eastern China, in this work, we examine the skill of the state-of-the-art climate models, evaluate the impact of sea surface temperature (SST) on forecast skill and estimate the predictability by using perfect model approach. The challenge is further demonstrated by assessing the ability of various reanalyses in capturing the observed summer rainfall variability in the eastern China and by examining the biases in reanalyses and in a climate model. Summer rainfall forecasts (hindcasts) initiated in May from eight seasonal forecast systems have low forecast skill with linear correlation of - 0.3 to 0.5 with observations. The low forecast skill is consistent with the low perfect model score ( 0.1-0.3) of atmospheric model forced by observed SST, due to the fact that external forcing (SST) may play a secondary role in the summer rainfall variation in the eastern China. This is a common feature for the climate variation over the middle and high latitude lands, where the internal dynamical processes dominate the rainfall variation in the eastern China and lead to low predictability, and external forcing (such as SST) plays a secondary role and is associated with predictable fraction. Even the reanalysis rainfall has some remarkable disagreements with the observation. Statistically, more than 20% of the observed variance is not captured by the mean of six reanalyses. Among the reanalyses, JRA55 stands out as the most reliable one. In addition, the reanalyses and climate model have pronounced biases in simulating the mean rainfall. These defaults mean an additional challenge in predicting the summer rainfall variability in the eastern China that has low predictability in nature.

Summer Session: A Time for Innovation

ERIC Educational Resources Information Center

Mola, Monty

2013-01-01

Summer is almost here (at least for those of us who teach semesters). Many of us are taking a well-deserved break to spend time with our families, conduct research, travel, and myriad other activities. Some of us, however, will be teaching summer school. For those of us lucky enough to be teaching this summer, we have one suggestion: Be bold!…

2016 Summer Olympic Games Site

Atmospheric Science Data Center

2016-12-30

article title:  Site of the 2016 Summer Olympic Games viewed by NASA's MISR     ... 2, 2016, just prior to the opening of the Summer Olympic Games. On the left is an image from MISR's nadir (downward-looking) camera; the ...

Report of Summer, 1980 Workshop. Roosevelt University/Chicago Board of Education Teacher Corps Project.

ERIC Educational Resources Information Center

Ginsberg, Rick; Melnick, Curtis C.

An overview is presented of the planning, activities and evaluation of a Teacher Corps summer workshop held in Chicago in 1981. Participants in the fifteen-day workshop were faculty and administrators from the Hyde Park Career Academy and Dumas Elementary School, community council members, and Teacher Corps interns. The purposes of the workshop…

Summer Reading

NASA Astrophysics Data System (ADS)

Pagni, Dick; Frech, Cheryl; Coppola, Brian; Kovac, Jeffrey; Harris, Hal

2007-06-01

Summer, a great time for leisure reading, a great time to try something different! Dick Pagni, Cheryl Frech, Brian Coppola, Jeffrey Kovac, and Hal Harris provide plenty of suggestions to keep you reading!

76 FR 64163 - Submission Deadline for Schedule Information for San Francisco International Airport for the...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-10-17

... Information for San Francisco International Airport for the Summer 2012 Scheduling Season AGENCY: Department... Guidelines (WSG) effective for the Summer 2012 scheduling season. The FAA has determined this designation is... with the Summer 2012 scheduling season to monitor major scheduling peaks that could result in lengthy...

Regime shift of Indian summer monsoon rainfall to a persistent arid state: external forcing versus internal variability

NASA Astrophysics Data System (ADS)

Srivastava, Ankur; Pradhan, Maheswar; Goswami, B. N.; Rao, Suryachandra A.

2017-11-01

The high propensity of deficient monsoon rainfall over the Indian sub-continent in the recent 3 decades (seven deficient monsoons against 3 excess monsoon years) compared to the prior 3 decades has serious implications on the food and water resources in the country. Motivated by the need to understand the high occurrence of deficient monsoon during this period, we examine the change in predictability of the Indian summer monsoon (ISM) and its teleconnections with Indo-Pacific sea surface temperatures between the two periods. The shift in the tropical climate in the late 1970s appears to be one of the major reasons behind this. We find an increased predictability of the ISM in the recent 3 decades owing to reduced `internal' interannual variability (IAV) due to the high-frequency modes, while the `external' IAV arising from the low-frequency modes has remained largely the same. The Indian Ocean Dipole-ISM teleconnection has become positive during the monsoon season in the recent period thereby compensating for the weakened ENSO-ISM teleconnection. The central Pacific El-Niño and the Indian Ocean (IO) warming during the recent 3 decades are working together to realise enhanced ascending motion in the equatorial IO between 70°E and 100°E, preconditioning the Indian monsoon system prone to a deficient state.

Summer Interns

Science.gov Websites

opportunity to work on projects that support particle physics experiments in areas such as engineering , applied physics and computing. In addition, Fermilab offers opportunities for environmental studies physics research or ecology. Students and teachers are selected for their outstanding scholarship and

Summer Training and Education Program (STEP): Report on the 1985 Summer Experience. Executive Summary.

ERIC Educational Resources Information Center

Branch, Alvia Y.

The Summer Training and Education Program (STEP) provides 14 and 15 year olds with a paid summer experience that combines work, remediation in reading and math, and life skills instruction. This national, federally funded program is a response to data which show that poor academic performance and teenage pregnancy are important contributors to…

Development in Mexico and Central America. Fulbright-Hays Summer Seminars Abroad Program. Summer 1991.

ERIC Educational Resources Information Center

Institute of International Education, New York, NY.

This document features writings and curriculum projects by teachers who traveled to Mexico and Central America in the summer of 1991 as members of a Fulbright-Hays Summer Seminar. The following items are among the 20 included: Curriculum Project: "'Escritoras Mexicanas Contemporaneas': A Survey of Mexican Women Fiction Writers" (Laura J.…

Goodbye to Summer Vacation? The Effects of Summer Enrollment on College and Employment Outcomes. A CAPSEE Working Paper

ERIC Educational Resources Information Center

Liu, Vivian Yuen Ting

2016-01-01

Despite rich evidence on the benefit of summer enrollment at the K-12 level, the college completion literature has so far focused on college readiness, remediation, and financial aid, and has largely overlooked the potential benefits of taking summer courses among college students. Academic momentum theory suggests that summer enrollment may…

Summer Reading

NASA Astrophysics Data System (ADS)

Harris, Harold H.; Pagni, Richard M.; Kovac, Jeffrey; Coppola, Brian P.

2003-06-01

Summer, a great time for leisure reading! Try to set aside some time and find a quiet spot, because Hal Harris, Dick Pagni, Jeff Kovac, and Brian Coppola have a variety of interesting suggestions for you.

Summer Reading

NASA Astrophysics Data System (ADS)

Pagni, Richard M.; Baldwin Frech, Cheryl; Coppola, Brian P.; Harris, Harold H.; Kovac, Jeffrey

2005-06-01

Summer, a great time for leisure reading, a great time to try something different! Cheryl Baldwin Frech joins regulars Dick Pagni, Brian Coppola, Hal Harris, and Jeff Kovac in providing plenty of suggestions to tempt you.

Peterson's Summer Study Abroad: A Guide to Summer Academic and Language Programs. First Edition.

ERIC Educational Resources Information Center

Peterson's Guides, Inc., Princeton, NJ.

This guide provides descriptions of over 900 summer academic and language study-abroad programs in 80 countries that range from 1-week language study courses to full-summer university programs. An introductory section provides general information on study abroad programs and the use of the guide. The bulk of the guide consists of individual…

Center for Advanced Modeling and Simulation Intern

ScienceCinema

Gertman, Vanessa

2017-12-13

Some interns just copy papers and seal envelopes. Not at INL! Check out how Vanessa Gertman, an INL intern working at the Center for Advanced Modeling and Simulation, spent her summer working with some intense visualization software. Lots more content like this is available at INL's facebook page http://www.facebook.com/idahonationallaboratory.

Center for Advanced Modeling and Simulation Intern

DOE Office of Scientific and Technical Information (OSTI.GOV)

Gertman, Vanessa

Some interns just copy papers and seal envelopes. Not at INL! Check out how Vanessa Gertman, an INL intern working at the Center for Advanced Modeling and Simulation, spent her summer working with some intense visualization software. Lots more content like this is available at INL's facebook page http://www.facebook.com/idahonationallaboratory.

Improve projections of changes in southern African summer rainfall through comprehensive multi-timescale empirical statistical downscaling

NASA Astrophysics Data System (ADS)

Dieppois, B.; Pohl, B.; Eden, J.; Crétat, J.; Rouault, M.; Keenlyside, N.; New, M. G.

2017-12-01

The water management community has hitherto neglected or underestimated many of the uncertainties in climate impact scenarios, in particular, uncertainties associated with decadal climate variability. Uncertainty in the state-of-the-art global climate models (GCMs) is time-scale-dependant, e.g. stronger at decadal than at interannual timescales, in response to the different parameterizations and to internal climate variability. In addition, non-stationarity in statistical downscaling is widely recognized as a key problem, in which time-scale dependency of predictors plays an important role. As with global climate modelling, therefore, the selection of downscaling methods must proceed with caution to avoid unintended consequences of over-correcting the noise in GCMs (e.g. interpreting internal climate variability as a model bias). GCM outputs from the Coupled Model Intercomparison Project 5 (CMIP5) have therefore first been selected based on their ability to reproduce southern African summer rainfall variability and their teleconnections with Pacific sea-surface temperature across the dominant timescales. In observations, southern African summer rainfall has recently been shown to exhibit significant periodicities at the interannual timescale (2-8 years), quasi-decadal (8-13 years) and inter-decadal (15-28 years) timescales, which can be interpret as the signature of ENSO, the IPO, and the PDO over the region. Most of CMIP5 GCMs underestimate southern African summer rainfall variability and their teleconnections with Pacific SSTs at these three timescales. In addition, according to a more in-depth analysis of historical and pi-control runs, this bias is might result from internal climate variability in some of the CMIP5 GCMs, suggesting potential for bias-corrected prediction based empirical statistical downscaling. A multi-timescale regression based downscaling procedure, which determines the predictors across the different timescales, has thus been used to

50 CFR 648.106 - Summer flounder possession restrictions.

Code of Federal Regulations, 2014 CFR

2014-10-01

... 50 Wildlife and Fisheries 12 2014-10-01 2014-10-01 false Summer flounder possession restrictions... Management Measures for the Summer Flounder Fisheries § 648.106 Summer flounder possession restrictions. (a... person shall possess more than four summer flounder in, or harvested from, the EEZ, unless that person is...

50 CFR 648.106 - Summer flounder possession restrictions.

Code of Federal Regulations, 2013 CFR

2013-10-01

... 50 Wildlife and Fisheries 12 2013-10-01 2013-10-01 false Summer flounder possession restrictions... Management Measures for the Summer Flounder Fisheries § 648.106 Summer flounder possession restrictions. (a... person shall possess more than four summer flounder in, or harvested from, the EEZ, unless that person is...

50 CFR 648.106 - Summer flounder possession restrictions.

Code of Federal Regulations, 2012 CFR

2012-10-01

... 50 Wildlife and Fisheries 12 2012-10-01 2012-10-01 false Summer flounder possession restrictions... Management Measures for the Summer Flounder Fisheries § 648.106 Summer flounder possession restrictions. (a... person shall possess more than two summer flounder in, or harvested from, the EEZ, unless that person is...

Summer Reading

NASA Astrophysics Data System (ADS)

Harris, Harold H.; Kovac, Jeffrey; Pagni, Richard M.; Coppola, Brian P.

2004-06-01

Summer, a great time for leisure reading! Try to set aside some time and find a quiet spot, because once again Hal Harris, Dick Pagni, Jeff Kovac, and Brian Coppola have a variety of interesting suggestions for you.

Acetyl-CoA carboxylase rewires cancer metabolism to allow cancer cells to survive inhibition of the Warburg effect by cetuximab

PubMed Central

Luo, Jingtao; Hong, Yun; Lu, Yang; Qiu, Songbo; Chaganty, Bharat K. R.; Zhang, Lun; Wang, Xudong; Li, Qiang; Fan, Zhen

2016-01-01

Cetuximab inhibits HIF-1-regulated glycolysis in cancer cells, thereby reversing the Warburg effect and leading to inhibition of cancer cell metabolism. AMP-activated protein kinase (AMPK) is activated after cetuximab treatment, and a sustained AMPK activity is a mechanism contributing to cetuximab resistance. Here, we investigated how acetyl-CoA carboxylase (ACC), a downstream target of AMPK, rewires cancer metabolism in response to cetuximab treatment. We found that introduction of experimental ACC mutants lacking the AMPK phosphorylation sites (ACC1_S79A and ACC2_S212A) into head and neck squamous cell carcinoma (HNSCC) cells protected HNSCC cells from cetuximab-induced growth inhibition. HNSCC cells with acquired cetuximab resistance contained not only high levels of T172-phosphorylated AMPK and S79-phosphorylated ACC1 but also an increased level of total ACC. These findings were corroborated in tumor specimens of HNSCC patients treated with cetuximab. Cetuximab plus TOFA (an allosteric inhibitor of ACC) achieved remarkable growth inhibition of cetuximab-resistant HNSCC xenografts. Our data suggest a novel paradigm in which cetuximab-mediated activation of AMPK and subsequent phosphorylation and inhibition of ACC is followed by a compensatory increase in total ACC, which rewires cancer metabolism from glycolysis-dependent to lipogenesis-dependent. PMID:27693630

Acetyl-CoA carboxylase rewires cancer metabolism to allow cancer cells to survive inhibition of the Warburg effect by cetuximab.

PubMed

Luo, Jingtao; Hong, Yun; Lu, Yang; Qiu, Songbo; Chaganty, Bharat K R; Zhang, Lun; Wang, Xudong; Li, Qiang; Fan, Zhen

2017-01-01

Cetuximab inhibits HIF-1-regulated glycolysis in cancer cells, thereby reversing the Warburg effect and leading to inhibition of cancer cell metabolism. AMP-activated protein kinase (AMPK) is activated after cetuximab treatment, and a sustained AMPK activity is a mechanism contributing to cetuximab resistance. Here, we investigated how acetyl-CoA carboxylase (ACC), a downstream target of AMPK, rewires cancer metabolism in response to cetuximab treatment. We found that introduction of experimental ACC mutants lacking the AMPK phosphorylation sites (ACC1_S79A and ACC2_S212A) into head and neck squamous cell carcinoma (HNSCC) cells protected HNSCC cells from cetuximab-induced growth inhibition. HNSCC cells with acquired cetuximab resistance contained not only high levels of T172-phosphorylated AMPK and S79-phosphorylated ACC1 but also an increased level of total ACC. These findings were corroborated in tumor specimens of HNSCC patients treated with cetuximab. Cetuximab plus TOFA (an allosteric inhibitor of ACC) achieved remarkable growth inhibition of cetuximab-resistant HNSCC xenografts. Our data suggest a novel paradigm in which cetuximab-mediated activation of AMPK and subsequent phosphorylation and inhibition of ACC is followed by a compensatory increase in total ACC, which rewires cancer metabolism from glycolysis-dependent to lipogenesis-dependent. Copyright © 2016 Elsevier Ireland Ltd. All rights reserved.

Autophagy promotes paclitaxel resistance of cervical cancer cells: involvement of Warburg effect activated hypoxia-induced factor 1-α-mediated signaling

PubMed Central

Peng, X; Gong, F; Chen, Y; Jiang, Y; Liu, J; Yu, M; Zhang, S; Wang, M; Xiao, G; Liao, H

2014-01-01

Paclitaxel is one of the most effective chemotherapy drugs for advanced cervical cancer. However, acquired resistance of paclitaxel represents a major barrier to successful anticancer treatment. In this study, paclitaxel-resistant HeLa sublines (HeLa-R cell lines) were established by continuous exposure and increased autophagy level was observed in HeLa-R cells. 3-Methyladenine or ATG7 siRNA, autophagy inhibitors, could restore sensitivity of HeLa-R cells to paclitaxel compared with parental HeLa cells. To determine the underlying molecular mechanism, differentially expressed proteins between HeLa and HeLa-R cells were identified by two-dimensional gel electrophoresis coupled with electrospray ionization quadrupole time-of-flight MS/MS. We found glycolysis-associated proteins were upregulated in HeLa-R cell lines. Inhibition of glycolysis by 2-deoxy-D-glucose or koningic acid could decrease autophagy and enhance sensitivity of HeLa-R cells to paclitaxel. Moreover, glycolysis could activate HIF1-α. Downregulation of HIF1-α by specific siRNA could decrease autophagy and resensitize HeLa-R cells to paclitaxel. Taken together, a possible Warburg effect activated HIF1-α-mediated signaling-induced autophagic pathway is proposed, which may provide new insight into paclitaxel chemoresistance. PMID:25118927

Pathways Intern Report

NASA Technical Reports Server (NTRS)

Huggett, Daniel James

2017-01-01

The National Aeronautics and Space Administration (NASA) provides a formal training program for prospective employees titled, Pathways Intern Employment. The Pathways program targets graduate and undergraduate students who strive to become an active contributor to NASA's goal of space exploration. The report herein provides an account of Daniel Huggett's Pathways experience for the Spring and Summer 2017 semesters.

50 CFR 648.108 - Summer flounder gear restrictions.

Code of Federal Regulations, 2014 CFR

2014-10-01

... 50 Wildlife and Fisheries 12 2014-10-01 2014-10-01 false Summer flounder gear restrictions. 648... Measures for the Summer Flounder Fisheries § 648.108 Summer flounder gear restrictions. (a) General. (1) Otter trawlers whose owners are issued a summer flounder permit and that land or possess 100 lb (45.4 kg...

50 CFR 648.108 - Summer flounder gear restrictions.

Code of Federal Regulations, 2012 CFR

2012-10-01

... 50 Wildlife and Fisheries 12 2012-10-01 2012-10-01 false Summer flounder gear restrictions. 648... Measures for the Summer Flounder Fisheries § 648.108 Summer flounder gear restrictions. (a) General. (1) Otter trawlers whose owners are issued a summer flounder permit and that land or possess 100 lb (45.4 kg...

50 CFR 648.108 - Summer flounder gear restrictions.

Code of Federal Regulations, 2013 CFR

2013-10-01

... 50 Wildlife and Fisheries 12 2013-10-01 2013-10-01 false Summer flounder gear restrictions. 648... Measures for the Summer Flounder Fisheries § 648.108 Summer flounder gear restrictions. (a) General. (1) Otter trawlers whose owners are issued a summer flounder permit and that land or possess 100 lb (45.4 kg...

22 CFR 62.32 - Summer work travel.

Code of Federal Regulations, 2011 CFR

2011-04-01

... 22 Foreign Relations 1 2011-04-01 2011-04-01 false Summer work travel. 62.32 Section 62.32 Foreign... Provisions § 62.32 Summer work travel. (a) Introduction. These regulations govern program participation in summer work travel programs conducted by Department of State-designated sponsors pursuant to the...

22 CFR 62.32 - Summer work travel.

Code of Federal Regulations, 2010 CFR

2010-04-01

... 22 Foreign Relations 1 2010-04-01 2010-04-01 false Summer work travel. 62.32 Section 62.32 Foreign... Provisions § 62.32 Summer work travel. (a) Introduction. These regulations govern program participation in summer work travel programs conducted by Department of State-designated sponsors pursuant to the...

PREFACE: 26th Summer School and International Symposium on the Physics of Ionized Gases (SPIG 2012)

NASA Astrophysics Data System (ADS)

Kuraica, Milorad; Mijatovic, Zoran

2012-11-01

This volume of Journal of Physics: Conference Series contains the general invited lectures, topical invited lectures and progress reports presented at the 26th Summer School and International Symposium on the Physics of Ionized Gases - SPIG 2012. The conference was held in Zrenjanin, Serbia, from 27-31 August. The SPIG conference has a 52 year long tradition. The structure of the papers in this volume cover the following sections: atomic collision processes, particle and laser beam interactions with solids, low temperature plasmas and general plasmas. As these four topics often overlap and merge in numerous fundamental studies and, more importantly applications, SPIG in general serves as a venue for exchanging ideas in the related fields. We hope that this volume will be an important source of information about progress in plasma physics and will be useful, first of all, for students, but also for plasma physics scientists. The Editors would like to thank the invited speakers for their participation at SPIG 2012 and for their efforts writing contributions for this volume. We also express our gratitude to the members of Scientific and Organizing committees for their efforts in organizing this SPIG. Especially we would like to thank the Ministry of Education, Science and Technological Development of Republic of Serbia, Provincial Secretariat for Science and Techonological Development, Province of Vojvodina, Institute Français de Serbie and Biser Zrenjanin for financial support as well as the European Physical Society (EPS) for supporting the award for the best poster of a young scientist and American Elements, USA. Milorad Kuraica Zoran Mijatovic October 2012 Editors

Summer Session Organizational Models at Canadian Universities

ERIC Educational Resources Information Center

Kops, Bill

2010-01-01

The issue of summer session organizational models continues to be of interest to summer session deans/directors and university administrators. The University of Victoria surveyed Canadian universities on this issue in 1994. Based on a similar survey done in 2009, this paper updates the status of Canadian university summer session organizational…

Finding Funds to Move Summer Learning Forward

ERIC Educational Resources Information Center

Seidel, Bob

2015-01-01

Summer learning loss creates a permanent drag on the US education system. With the generous support of the Charles Stewart Mott Foundation, the National Summer Learning Association (NSLA) developed "Moving Summer Learning Forward: A Strategic Roadmap for Funding in Tough Times" to provide out-of-school time programs, school districts,…

International Higher Education in Facts and Figures. Summer 2010

ERIC Educational Resources Information Center

Universities UK, 2010

2010-01-01

This paper presents facts and figures of the international higher education. Facts reveal that the UK sells more brainpower per capita than anywhere else in the world. The UK has 1% of the world's population but undertakes 5% of the world's scientific research and produces 14% of the world's most highly cited papers (Universities UK 2010). More…

Education in Summer: 100 Years at UW-Madison.

ERIC Educational Resources Information Center

Wisconsin Univ., Madison.

College summer sessions, and specifically the summer program at the University of Wisconsin-Madison between 1885-1985 are discussed in two papers and a conference summary. In "History of Summer School at the University of Wisconsin," John W. Jenkins and Barry J. Teicher examine the emergence and nature of summer programs in the context of the…

Summer Reading

NASA Astrophysics Data System (ADS)

Kovac, Jeffrey; Pagni, Richard M.; Harris, Harold H.; Coppola, Brian P.

2002-06-01

Ah, summer approaches! Perhaps you will find some time for leisure reading. With this hope in mind, here are a few suggestions that Jeff Kovac, our Book & Media Reviews Editor, has assembled with the help of Dick Pagni, Hal Harris, and Brian Coppola.

Summer Reading

NASA Astrophysics Data System (ADS)

Kovac, Jeffrey; Pagni, Richard; Harris, Harold H.; Coppola, Brian P.

2001-06-01

Ah, summer approaches! Perhaps you will find some time for leisure reading. With this hope in mind, here are a few suggestions that Jeff Kovac, our Book & Media Reviews Editor, has assembled with the help of Dick Pagni, Hal Harris, and Brian Coppola.

A 2006 SPS Summer Intern’s Experiences, Reflections, and Future Ambitions

NASA Astrophysics Data System (ADS)

Deml, Ann

2006-12-01

As a SPS Summer Intern from the University of Wisconsin-River Falls, I spent nine weeks in the Washington, D.C. area working with the American Physical Society. My work dealt primarily with the development of a ComPADRE outreach website, Physics To Go, which offers the public opportunities to engage in informal physics learning. Specific tasks that I performed included locating content to feature on the homepage, obtaining photographer permissions, and cataloging quality websites into the digital library. At the conclusion of the summer, I accepted an offer to continue working on Physics To Go and have further contributed to its expansion. Participating in this internship has influenced my life in several respects, and as a result, I will be enrolling in a graduate program this coming year. Additionally, I am making plans to participate in a National Student Exchange program and am considering a career with a greater emphasis on research. The internship has served as an invaluable and irreplaceable experience.

"Learning City" Summer Migrant Program.

ERIC Educational Resources Information Center

Presson, Johnny E.; Baker, Wilbur L.

"Learning City" is the theme of a summer education project that provides a unique teaching atmosphere for migrant children. For 2 summers, 130 students have participated in this program that sustains and enforces reading and math skills, as well as helps develop self-concept. Industries in Learning City are the various branches of study: reading…

Summer Monsoon, Kalahari Desert, Africa

NASA Image and Video Library

1992-11-01

STS052-152-047 (22 Oct- 1 Nov 1992) --- The Kalahari Desert had not seen any significant rainfall for months before the launch of STS-52. Here, Shuttle astronauts have captured the onset of the (Southern Hemisphere) summer monsoon over the Kalahari Desert, as illustrated by the large thunderstorm towers poking up through the sun's terminator. The summer monsoon, with its associated thunderstorms, generally lasts from November through March. Scientist observers of this area report that the summer monsoon contributes most of the annual rainfall to this environmentally sensitive area. Shuttle nadir position: 28.0 degrees south, 25.1 degrees east. The center of the scene is 22.0 degrees south, 25.0 degrees east, 16:20:04 GMT.

PREFACE: Fifteenth International Summer School on Vacuum, Electron and Ion Technologies (VEIT 2007)

NASA Astrophysics Data System (ADS)

Guerassimov, Nikolay; Möller, Wolfhard; Ghelev, Chavdar

2008-03-01

The International Summer School on Vacuum, Electron and Ion Technologies (VEIT) has been organized biannually since 1977. It is a forum for the interchange and dissemination of knowledge and ideas on the latest developments in electron-, ion-, and plasma-assisted technologies. The organizers of the event (since 2001) have been the Institute of Electronics, Bulgarian Academy of Sciences, Sofia, Bulgaria, the Institute of Ion Beam Physics and Materials Research, Forschungszentrum Dresden-Rossendorf, Dresden, Germany, and the Evrika Foundation, Sofia, Bulgaria. The fifteenth meeting of VEIT was held in the Black Sea resort of Sozopol, Bulgaria from 17-21 September 2007 and was attended by around 120 participants from 17 countries: Australia, Belgium, Bulgaria, Canada, Czech Republic, Germany, Hungary, Italy, The Netherlands, Poland, Pakistan, Romania, Sweden, Switzerland, Ukraine, UK and USA. Following the tradition of publishing the VEIT Proceedings, a selection of papers presented at the event is published in this volume of Journal of Physics: Conference Series, all peer reviewed to meet the originality and quality criteria of the journal. The school consisted of 11 oral and 3 poster sessions. There were 17 invited talks of general interest and 12 progress reports were presented orally. In total 86 contributed papers were presented during the three poster sessions. There were several scientific highlights covering the fundamentals of gas discharges and interaction of fast particles with solids, a wide range of conventional and novel applications such as for hard coatings and optical/protective layers, nanosized structures produced by evaporation, sputtering or external irradiation. Recent achievements in the modification of materials using charged particles or laser beams, thin layers deposition, properties, and characterization and novel materials, techniques, devices were highlighted. Despite the busy scientific program, the atmosphere was relaxed and informal

Stratospheric variability in summer

NASA Technical Reports Server (NTRS)

Rind, D.; Donn, W. L.; Robinson, W.

1981-01-01

Rocketsonde observations and infrasound results are used to investigate the variability of the summer stratopause region during one month in summer. Fluctuations of 2-3 days and about 16-day periods are evident, and they appear to be propagating vertically. In this month the 2-3 day oscillations have an amplitude envelope equal in period to the longer period oscillations, implying a connection between the two phenomena. Observations of the diurnal tide and shorter period variability during the month are also presented.

PREFACE: 16th International Summer School on Vacuum, Electron, and Ion Technologies (VEIT 2009)

NASA Astrophysics Data System (ADS)

Möller, Wolfhard; Guerassimov, Nikolay; Ghelev, Chavdar

2010-04-01

The International Summer School on Vacuum, Electron and Ion Technologies (VEIT) has been organized biennially since 1977 when the series of VEIT Schools was launched by the Institute of Electronics, Bulgarian Academy of Sciences with the aim to act as a forum for interchange and dissemination of knowledge and ideas on the latest developments in electron-, ion-, and plasma-assisted technologies. Beginning from 2001, the school has been jointly organized with the Institute of Ion Beam Physics and Materials Research, Forschungszentrum Dresden-Rossendorf, Germany. Whereas, the school initially provided a meeting place for researchers mainly from Eastern and Central European countries, its importance grew issue by issue. The school is now a major scientific event and a meeting place for young scientists from Eastern and Western Europe involved in research and development associated with high-tech industries. Many former school participants have gone on to become leading scientists in research establishments and companies throughout the world. Leading international companies, such as High Voltage Engineering, Balzers, Varian, and Hauzer have used the VEIT forum to present their products through oral presentations, poster contributions or exhibits. The School Proceedings have been published in special issues of the international journals Vacuum, Plasma Processes and Polymers, Journal of Physics: Conference Series. The Sixteenth VEIT school was held in the Black Sea resort Sunny Beach, Bulgaria on 28 September to 2 October 2009. It was attended by close to 110 participants from 13 countries: Belgium, Bulgaria, Czech Republic, France, Germany, The Netherlands, Romania, Slovak Republic, Spain, Sweden, Ukraine, UK and USA. Following the tradition of publishing the VEIT Proceedings, a selection of papers presented at the event is published in this volume of Journal of Physics: Conference Series, under the originality and quality criteria of acceptance by the journal, including

Close the Achievement Gap with Summer Learning

ERIC Educational Resources Information Center

Huggins, Gary

2012-01-01

Summer vacation from school can bring afternoons at the swimming pool, family vacations, and maybe a spirit-filled summer camp that ignites a passion for art or rock climbing. But for many children, summer also means setbacks in learning that take a tremendous toll on teaching and student performance over time. PTA leaders can make a vital…

Ticket to a First Class Summer.

ERIC Educational Resources Information Center

Instructor, 1987

1987-01-01

Eight reproducible pages are offered for teachers to use as a summer send-off package which contains activities extending from a child's backyard to outer space. A list of books for summer reading is included. (MT)

Summer Curriculum | Cancer Prevention Fellowship Program

Cancer.gov

All Cancer Prevention Fellows are required to attend the NCI Summer Curriculum in Cancer Prevention during their first full summer at NCI. The curriculum has two courses, which are also open to the general scientific community worldwide.

What Is a Summer Job Worth? The Impact of Summer Youth Employment on Academic Outcomes

ERIC Educational Resources Information Center

Leos-Urbel, Jacob

2014-01-01

This paper estimates the impact of New York City's Summer Youth Employment Program (SYEP) on school attendance and other educational outcomes in the following school year for a large sample of low-income high school students. The program provides summer jobs and training to youth aged 14 to 21, and due to high demand allocates slots through a…

Summer Opportunities.

ERIC Educational Resources Information Center

Winds of Change, 2002

2002-01-01

This directory describes 24 summer internships and cooperative education programs for college students, especially in the science, engineering, and technology fields. A few programs are specifically for American Indians, minority groups, or college-bound high school students. Program entries include a brief description, skills and background…

Computer Summer Camp.

ERIC Educational Resources Information Center

Zabinski, Toby F.; Zabinski, Michael P.

1979-01-01

Describes the objectives, organization, and daily activities of a youth summer camp program providing general knowledge about computers, computing, social implications of computers, and opportunities for careers. (CMV)

Characteristics of effective summer learning programs in practice.

PubMed

Bell, Susanne R; Carrillo, Natalie

2007-01-01

The Center for Summer Learning examined various summer program models and found that there are nine characteristics that provide a framework for effective summer programs. In this chapter, the authors demonstrate how effective practices lead to positive results for young people. The nine characteristics of effective summer learning programs are (1) accelerating learning, (2) youth development, (3) proactive approach to summer learning, (4) leadership, (5) advanced planning, (6) staff development, (7) strategic partnerships, (8) evaluation and commitment to program improvement, and (9) sustainability and cost-effectiveness. These characteristics are divided into two sections. The first three characteristics address a program's approach to learning. Summer instructional techniques are most effective when academic learning is woven into enrichment activities and youth development. The second section covers program infrastructure to ensure the organization achieves and maintains quality programming. The nine characteristics complement each other to ensure a strong program that works to prevent summer learning loss and narrow the achievement gap. To demonstrate the variety of high-quality programs that include the nine characteristics, thirteen program profiles at the conclusion of the chapter each highlight one of the characteristics. These profiles show the various approaches that different summer programs have developed to accelerate academic achievement and promote positive development for young people in their communities.

2008 summer transportation institute final report.

DOT National Transportation Integrated Search

2009-01-01

Missouri LTAP at MST has hosted a USDOT Summer Transportation Institute (STI) for the past several years. The program has very successful and will again be offered in summer 2008. The STI is a 2, 2-week intensive learning experience held during the :...

First Outcomes from the National Summer Learning Study. Brief

ERIC Educational Resources Information Center

McCombs, Jennifer Sloan; Pane, John F.; Augustine, Catherine H.; Schwartz, Heather L.; Martorell, Paco; Zakaras, Laura

2014-01-01

Many students lose knowledge and skills over the long summer break, and research suggests that low-income students fall further behind over the summer than their higher-income peers. Voluntary summer learning programs may provide an opportunity to stem summer learning loss and give struggling students additional learning opportunities. The Wallace…

50 CFR 648.105 - Summer flounder recreational fishing season.

Code of Federal Regulations, 2012 CFR

2012-10-01

... 50 Wildlife and Fisheries 12 2012-10-01 2012-10-01 false Summer flounder recreational fishing... Management Measures for the Summer Flounder Fisheries § 648.105 Summer flounder recreational fishing season... under § 648.4(a)(3), and fishermen subject to the possession limit, may fish for summer flounder from...

50 CFR 648.105 - Summer flounder recreational fishing season.

Code of Federal Regulations, 2014 CFR

2014-10-01

... 50 Wildlife and Fisheries 12 2014-10-01 2014-10-01 false Summer flounder recreational fishing... Management Measures for the Summer Flounder Fisheries § 648.105 Summer flounder recreational fishing season... under § 648.4(a)(3), and fishermen subject to the possession limit, may fish for summer flounder from...

50 CFR 648.105 - Summer flounder recreational fishing season.

Code of Federal Regulations, 2013 CFR

2013-10-01

... 50 Wildlife and Fisheries 12 2013-10-01 2013-10-01 false Summer flounder recreational fishing... Management Measures for the Summer Flounder Fisheries § 648.105 Summer flounder recreational fishing season... under § 648.4(a)(3), and fishermen subject to the possession limit, may fish for summer flounder from...

ADMINISTRATIVE HANDBOOK ON SUMMER SECONDARY SCHOOLS.

ERIC Educational Resources Information Center

PARKER, ROBERT E.

REGULATIONS, SCHEDULES, AND SUGGESTED ADMINISTRATIVE PROCEDURES FOR SECONDAY LEVEL SUMMER SCHOOLS ARE INCLUDED IN AN ADMINISTRATIVE HANDBOOK. SPECIFIC ENTRIES DEAL WITH SUCH TOPICS AS PURPOSES OF THE SUMMER SCHOOLS, REQUIREMENTS FOR APPROVAL OF A SCHOOL, REGIONAL COOPERATION, CONSERVATION OF TALENT PROGRAMS, VARIOUS REQUIREMENTS AND CREDIT…

Summer Schools in Nuclear and Radiochemistry

DOE Office of Scientific and Technical Information (OSTI.GOV)

Silber, Herbert B.

The ACS Summer Schools in Nuclear and Radiochemistry (herein called “Summer Schools”) were funded by the U.S. Department of Energy and held at San Jose State University (SJSU) and Brookhaven National Laboratory (BNL). The Summer Schools offer undergraduate students with U.S. citizenship an opportunity to complete coursework through ACS accredited chemistry degree programs at SJSU or the State University of New York at Stony Brook (SBU). The courses include lecture and laboratory work on the fundamentals and applications of nuclear and radiochemistry. The number of students participating at each site is limited to 12, and the low student-to-instructor ratio ismore » needed due to the intense nature of the six-week program. To broaden the students’ perspectives on nuclear science, prominent research scientists active in nuclear and/or radiochemical research participate in a Guest Lecture Series. Symposia emphasizing environmental chemistry, nuclear medicine, and career opportunities are conducted as a part of the program. The Department of Energy’s Office of Basic Energy Sciences (BES) renewed the five-year proposal for the Summer Schools starting March 1, 2007, with contributions from Biological and Environmental Remediation (BER) and Nuclear Physics (NP). This Final Technical Report covers the Summer Schools held in the years 2007-2011.« less

Effective Summer Programming: What Educators and Policymakers Should Know

ERIC Educational Resources Information Center

McEachin, Andrew; Augustine, Catherine H.; McCombs, Jennifer

2018-01-01

The evidence suggests that many types of summer learning programs have the potential to reduce summer learning losses and perhaps create learning gains. However, implementing a summer program does not guarantee positive effects on students' learning. A key question then is: What factors make a summer learning program effective? This article, drawn…

The Summer Learning of Exceptional Students

ERIC Educational Resources Information Center

Gershenson, Seth; Hayes, Michael S.

2017-01-01

The summer activities and summer learning of exceptional students--students who have an individualized education plan or who are English-language learners--are potentially important yet understudied. We analyze nationally representative survey data to fill this gap. Exceptional students are significantly less likely than their mainstream…

Preventing Summer Learning Loss: Results of a Summer Literacy Program for Students from Low-SES Homes

ERIC Educational Resources Information Center

Bowers, Lisa M.; Schwarz, Ilsa

2018-01-01

Among the academic challenges faced by students from low-socioeconomic status (SES) homes is the loss of academic skills during the summer months. A total of 22 elementary students from low-SES homes participated in a summer program designed to improve oral and written narrative skills. We gathered oral and written narrative samples at the…

Summer School Effects in a Randomized Field Trial

ERIC Educational Resources Information Center

Zvoch, Keith; Stevens, Joseph J.

2013-01-01

This field-based randomized trial examined the effect of assignment to and participation in summer school for two moderately at-risk samples of struggling readers. Application of multiple regression models to difference scores capturing the change in summer reading fluency revealed that kindergarten students randomly assigned to summer school…

Parker Migrant Summer Story. A Report from Parker Summer School Migrant Program: Kindergarten Through Grade Six.

ERIC Educational Resources Information Center

Pollard, Merel E., Comp.

Before the beginning of the summer school, a workshop was held for the teachers and aides to present ways to: (1) make migrant and American Indian children more aware of their heritage and (2) help them become more familiar with career possibilities. Objectives of the summer program were: (1) career exploration; (2) cultural enrichment (i.e., art,…

Targeting the Warburg effect with a novel glucose transporter inhibitor to overcome gemcitabine resistance in pancreatic cancer cells

PubMed Central

Lai, I-Lu; Chou, Chih-Chien; Lai, Po-Ting; Fang, Chun-Sheng; Shirley, Lawrence A.; Yan, Ribai; Mo, Xiaokui; Bloomston, Mark; Kulp, Samuel K.; Bekaii-Saab, Tanios; Chen, Ching-Shih

2014-01-01

Gemcitabine resistance remains a significant clinical challenge. Here, we used a novel glucose transporter (Glut) inhibitor, CG-5, as a proof-of-concept compound to investigate the therapeutic utility of targeting the Warburg effect to overcome gemcitabine resistance in pancreatic cancer. The effects of gemcitabine and/or CG-5 on viability, survival, glucose uptake and DNA damage were evaluated in gemcitabine-sensitive and gemcitabine-resistant pancreatic cancer cell lines. Mechanistic studies were conducted to determine the molecular basis of gemcitabine resistance and the mechanism of CG-5-induced sensitization to gemcitabine. The effects of CG-5 on gemcitabine sensitivity were investigated in a xenograft tumor model of gemcitabine-resistant pancreatic cancer. In contrast to gemcitabine-sensitive pancreatic cancer cells, the resistant Panc-1 and Panc-1GemR cells responded to gemcitabine by increasing the expression of ribonucleotide reductase M2 catalytic subunit (RRM2) through E2F1-mediated transcriptional activation. Acting as a pan-Glut inhibitor, CG-5 abrogated this gemcitabine-induced upregulation of RRM2 through decreased E2F1 expression, thereby enhancing gemcitabine-induced DNA damage and inhibition of cell survival. This CG-5-induced inhibition of E2F1 expression was mediated by the induction of a previously unreported E2F1-targeted microRNA, miR-520f. The addition of oral CG-5 to gemcitabine therapy caused greater suppression of Panc-1GemR xenograft tumor growth in vivo than either drug alone. Glut inhibition may be an effective strategy to enhance gemcitabine activity for the treatment of pancreatic cancer. PMID:24879635

Antifreeze protein-induced superheating of ice inside Antarctic notothenioid fishes inhibits melting during summer warming

PubMed Central

Cziko, Paul A.; DeVries, Arthur L.; Evans, Clive W.; Cheng, Chi-Hing Christina

2014-01-01

Antifreeze proteins (AFPs) of polar marine teleost fishes are widely recognized as an evolutionary innovation of vast adaptive value in that, by adsorbing to and inhibiting the growth of internalized environmental ice crystals, they prevent death by inoculative freezing. Paradoxically, systemic accumulation of AFP-stabilized ice could also be lethal. Whether or how fishes eliminate internal ice is unknown. To investigate if ice inside high-latitude Antarctic notothenioid fishes could melt seasonally, we measured its melting point and obtained a decadal temperature record from a shallow benthic fish habitat in McMurdo Sound, Antarctica. We found that AFP-stabilized ice resists melting at temperatures above the expected equilibrium freezing/melting point (eqFMP), both in vitro and in vivo. Superheated ice was directly observed in notothenioid serum samples and in solutions of purified AFPs, and ice was found to persist inside live fishes at temperatures more than 1 °C above their eqFMP for at least 24 h, and at a lower temperature for at least several days. Field experiments confirmed that superheated ice occurs naturally inside wild fishes. Over the long-term record (1999–2012), seawater temperature surpassed the fish eqFMP in most summers, but never exceeded the highest temperature at which ice persisted inside experimental fishes. Thus, because of the effects of AFP-induced melting inhibition, summer warming may not reliably eliminate internal ice. Our results expose a potentially antagonistic pleiotropic effect of AFPs: beneficial freezing avoidance is accompanied by melting inhibition that may contribute to lifelong accumulation of detrimental internal ice crystals. PMID:25246548

Antifreeze protein-induced superheating of ice inside Antarctic notothenioid fishes inhibits melting during summer warming.

PubMed

Cziko, Paul A; DeVries, Arthur L; Evans, Clive W; Cheng, Chi-Hing Christina

2014-10-07

Antifreeze proteins (AFPs) of polar marine teleost fishes are widely recognized as an evolutionary innovation of vast adaptive value in that, by adsorbing to and inhibiting the growth of internalized environmental ice crystals, they prevent death by inoculative freezing. Paradoxically, systemic accumulation of AFP-stabilized ice could also be lethal. Whether or how fishes eliminate internal ice is unknown. To investigate if ice inside high-latitude Antarctic notothenioid fishes could melt seasonally, we measured its melting point and obtained a decadal temperature record from a shallow benthic fish habitat in McMurdo Sound, Antarctica. We found that AFP-stabilized ice resists melting at temperatures above the expected equilibrium freezing/melting point (eqFMP), both in vitro and in vivo. Superheated ice was directly observed in notothenioid serum samples and in solutions of purified AFPs, and ice was found to persist inside live fishes at temperatures more than 1 °C above their eqFMP for at least 24 h, and at a lower temperature for at least several days. Field experiments confirmed that superheated ice occurs naturally inside wild fishes. Over the long-term record (1999-2012), seawater temperature surpassed the fish eqFMP in most summers, but never exceeded the highest temperature at which ice persisted inside experimental fishes. Thus, because of the effects of AFP-induced melting inhibition, summer warming may not reliably eliminate internal ice. Our results expose a potentially antagonistic pleiotropic effect of AFPs: beneficial freezing avoidance is accompanied by melting inhibition that may contribute to lifelong accumulation of detrimental internal ice crystals.

FOREWORD: Corfu Summer Institute on Elementary Particle Physics (CORFU2005)

NASA Astrophysics Data System (ADS)

Anagnostopoulos, Konstantinos; Antoniadis, Ignatios; Fanourakis, George; Kehagias, Alexandros; Savoy-Navarro, Aurore; Wess, Julius; Zoupanos, George

2006-12-01

These are the Proceedings of the Corfu Summer Institute on Elementary Particle Physics (CORFU2005) (http://corfu2005.physics.uoi.gr), which took place in Corfu, Greece from 4 - 26 September 2005. The Corfu Summer Institute has a very long, interesting and successful history, some elements of which can be found in http://www.corfu-summer-institute.gr. In short, the Corfu Meeting started as a Summer School on Elementary Particle Physics (EPP) mostly for Greek graduate students in 1982 and has developed into a leading international Summer Institute in the field of EPP, both experimental and theoretical, providing in addition a very rich outreach programme to teachers and school students. The CORFU2005 Summer Institute on EPP, although based on the general format that has been developed and established in the Corfu Meetings during previous years, is characterized by the fact that it was a full realization of a new idea, which started experimentally in the previous two Corfu Meetings. The successful new ingredient was that three European Marie Curie Research Training Networks decided to hold their Workshops in Corfu during September 2005 and they managed to coordinate the educational part of their meetings to a huge Summer School called `The 8th Hellenic School on Elementary Particle Physics' (4 - 11 September). The European Networks which joined forces to materialize this project and the corresponding dates of their own Workshops are:

Summer Skies

ERIC Educational Resources Information Center

Science Scope, 2005

2005-01-01

During the evening hours of the summer of 2005, there will be numerous opportunities to observe several of the brighter planets as they move along their respective orbits, overtaking and passing one another, performing a planetary dance with the choreography set to orbital speeds. With the exception of Mars, the visible planets will all be in the…

Summer Camp.

ERIC Educational Resources Information Center

Pfisterer, Bill

About 50 participants and 8 supervisors attended the Summer Camp. Visitors were encouraged and parents often came to see what their kids were doing. Before arriving at camp, the students learned how important balancing the supplies was when loading the boats. On the way to camp, students studied the: (1) landmarks so that they could find their way…

Summer Melts Immigrant Students' College Plans

ERIC Educational Resources Information Center

Naranjo, Melissa M.; Pang, Valerie Ooka; Alvarado, Jose Luis

2016-01-01

Many college-intending students find themselves dealing with the undermatch and summer melt phenomena. Undermatch refers to the situation where academically-successful high-school graduates choose not to go to any college or to go to a local community college not commensurate with their academic achievements. Summer melt describes how students may…

Districts Add Web Courses for Summer

ERIC Educational Resources Information Center

Borja, Rhea R.

2005-01-01

More and more school districts, as well as for-profit companies and nonprofit organizations, are offering Internet-based summer classes in core subjects, such as algebra and reading, and electives such as creative writing. In this article, the author discusses the growth of enrollment in online education for summer. The logistical ease of…

Building Effective Programs for Summer Learning.

ERIC Educational Resources Information Center

Johnson, Peter

Summer learning comes from reading books, singing songs, playing games, listening to stories, taking trips, and all kinds of other fun activities that kids rarely realize are actually good for them. However, this kind of summer learning can be more difficult for children of low-income and other disadvantaged families. Careful analysis of…

Observations of the summer Red Sea circulation

NASA Astrophysics Data System (ADS)

Sofianos, Sarantis S.; Johns, William E.

2007-06-01

Aiming at exploring and understanding the summer circulation in the Red Sea, a cruise was conducted in the basin during the summer of 2001 involving hydrographic, meteorological, and direct current observations. The most prominent feature, characteristic of the summer circulation and exchange with the Indian Ocean, is a temperature, salinity, and oxygen minimum located around a depth of 75 m at the southern end of the basin, associated with Gulf of Aden Intermediate Water inflowing from the Gulf of Aden during the summer season as an intruding subsurface layer. Stirring and mixing with ambient waters lead to marked increases in temperature (from 16.5 to almost 33°C) and salinity (from 35.7 to more than 38 psu) in this layer by the time it reaches midbasin. The observed circulation presents a very vigorous pattern with strong variability and intense features that extend the width of the basin. A permanent cyclone, detected in the northern Red Sea, verifies previous observations and modeling studies, while in the central sector of the basin a series of very strong anticyclones were observed with maximum velocities exceeding 1 m/s. The three-layer flow pattern, representative of the summer exchange between the Red Sea and the Gulf of Aden, is observed in the strait of Bab el Mandeb. In the southern part of the basin the layer flow is characterized by strong banking of the inflows and outflows against the coasts. Both surface and intermediate water masses involved in the summer Red Sea circulation present prominent spatial variability in their characteristics, indicating that the eddy field and mixing processes play an important role in the summer Red Sea circulation.

Internal wave damping in the East China in late summer 2014

NASA Astrophysics Data System (ADS)

Kuh Kang, Sok; Lee, Jae Hak; Park, Jae-Hun; Kim, Eun Jin; Hong, Chang Su

2016-04-01

A field measurement was carried out to observe generation, propagation and damping of the internal waves on the continental shelf around 31N in the East China Sea during September 16-27, 2014. Two trawl-resistant bottom mount ADCPs (M1, M2) were deployed along 126.5oE with 10 km apart. Over the 10 km distance the dominant frequency internal wave group with periods around 500 s is estimated to dissipate its energy by about 30%. The damping process appears to be partly related with the higher-mode evolution at the downward station M1, compared with the 1st-mode dominancy at the upstream station (M2). Our observations suggest that the damping processes of internal waves on the continental shelf of the East China Sea occur by rather complicated manners than by the simple process due to frictional decaying. This work was partially supported by KIOST projects (PE99396)and this research has been performed as collaborative research project of project No (Development of HPC-based management system againstnational scale disaster) and supported by the KOREA INSTITUTE of SCIENCE and TECHNOLOGY INFORMATION (KISTI).

Rhode Island's Innovative Solutions to Summer Learning Loss

ERIC Educational Resources Information Center

Greenman, Adam

2015-01-01

Summer learning loss has been documented in the United States since early in the 20th century. These early studies measured differences in test scores at the beginning of the summer and at the end, and discovered that students did not retain information during the summer. Studies conducted throughout the 20th century confirmed this. Later studies…

Summer of Innovation Kick Off

NASA Image and Video Library

2010-06-09

Erin Gilbert, Director of Professional Development from the National Summer Learning Associations, motivates teachers and middle school students during the kick off of NASA's Summer of Innovation program at the Jet Propulsion Laboratory in Pasadena, Calif., Thursday, June 10, 2010. Through the program, NASA will engage thousands of middle school students and teachers in stimulating math and science-based education programs with the goal of increasing the number of future scientists, mathematicians, and engineers. Photo Credit: (NASA/Bill Ingalls)

A New Vision for Summer School

ERIC Educational Resources Information Center

Smink, Jeff

2012-01-01

Summer school makes an unlikely candidate for a bright spot in education reform during these difficult economic times. It occupies a long-held negative place in U.S. culture, prompting dread in the hearts of many former and current students. Summer school conjures up images of sitting in hot classrooms and receiving remedial instruction while…

PREFACE: 24th Summer School and International Symposium on the Physics of Ionized Gases

NASA Astrophysics Data System (ADS)

Malović, Gordana; Popović, Luka Č.; Dimitrijević, Milan S.

2008-02-01

This volume of the Journal of Physics: Conference Series contains the Invited lectures, Topical invited lectures and Progress reports presented at the 24th Summer School and International Symposium on the Physics of Ionized Gases - SPIG 2008. The conference was held in Novi Sad, Serbia, 25-29 August 2008. Throughout the history of scientific discovery, one can see repeatedly how fundamental sciences have solved basic questions and opened new frontiers. In the field of physics, there are many key discoveries, resulting in their useful applications for the benefit of the mankind. It is very important to have meetings to discuss actual problems in particular fields of physics. This Conference provided a forum for 160 active researchers from 25 countries to discuss current advances in the physics of ionized gases and related fields. The Conference has a long tradition. Let us remember that the first SPIG was organized in 1968. The decay of former Yugoslavia in 1991, caused a disturbance in SPIG meetings, but fortunately, in 1993, SPIG meetings were successfully revitalized. During recent years we have met successively in Belgrade, Kotor, Zlatibor, Soko Banja, Tara, Kopaonik and finally this time in Novi Sad. The structure of the papers in this Proceedings is as follows: Atomic Collision Processes, Particle and Laser Beam Interactions with Solids, Low Temperature Plasmas and General Plasmas. We hope that this Proceedings will be an important source of information, first of all to students, and also to plasma physics scientists. First of all, we would like to thank to the invited speakers for participating at the SPIG 2008 and for their efforts writing contributions for this Proceedings. We also express our gratitude to the members of the Scientific and Organizing committees for their efforts in organizing the Conference. Especially we would like to thank the Ministry of Science and Technological Development of the Republic of Serbia for financial support. Also, this

Manual for a Summer Reading Program.

ERIC Educational Resources Information Center

Medina, Sue O.

This manual provides suggestions for materials and projects to carry out a summer reading program for children based on a monster theme. The planning process outlined may be used as a "how-to" guide for developing summer reading programs on other themes as well. In addition to general guidelines, the manual provides information on the following…

Measuring Mindfulness in Summer Camp Staff

ERIC Educational Resources Information Center

Gillard, Ann; Roark, Mark F.; Nyaga, Lewis Ramsey Kanyiba; Bialeschki, M. Deborah

2011-01-01

Examining mindfulness in a non-clinical and non-therapeutic setting such as a summer camp is an area of growing interest. Our study tested three mindfulness scales with staff in a summer camp setting, and we conducted preliminary reliability and validity analyses for any modifications needed in the scales. Results indicated two major findings: (a)…

Idea Bank: Summer Music Programs for Students.

ERIC Educational Resources Information Center

Anderson, Tom; And Others

1989-01-01

Describes the elements of high quality summer music programs for students. Points out considerations for selection of a summer music camp, including setting daily schedule, amount of performance and private lessons, cost, faculty, and program scope. (LS)

Cloud condensation nuclei closure study on summer arctic aerosol

NASA Astrophysics Data System (ADS)

Martin, M.; Chang, R. Y.-W.; Sierau, B.; Sjogren, S.; Swietlicki, E.; Abbatt, J. P. D.; Leck, C.; Lohmann, U.

2011-03-01

We present an aerosol - cloud condensation nuclei CCN) closure study on summer high Arctic aerosol based on measurements that were carried out in summer 2008 during the Arctic Summer Cloud Ocean Study (ASCOS) on board the Swedish ice breaker Oden. The data presented here were collected during a three-week time period in the pack ice (>85° N) when the icebreaker Oden was moored to an ice floe and drifted passively during the most biological active period into autumn freeze up conditions. CCN number concentrations were obtained using two CCN counters measuring at different supersaturations. The directly measured CCN number concentration is then compared with a CCN number concentration calculated using both bulk aerosol mass composition data from an aerosol mass spectrometer and aerosol number size distributions obtained from a differential mobility particle sizer, assuming κ-Köhler theory and an internally mixed aerosol. For the two highest measured supersaturations, 0.73 and 0.41%, closure could not be achieved with the investigated settings concerning hygroscopicity and density. The calculated CCN number concentration was always higher than the measured one. One possible explanation is that the smaller particles that activate at these supersaturations have a relative larger insoluble organic mass fraction and thus are less good CCN than the larger particles. At 0.20, 0.15 and 0.10% supersaturation, the measured CCN number can be represented with different parameters for the hygroscopicity and density of the particles. For the best agreement of the calculated CCNnumber concentration with the measured one the organic fraction of the aerosol needs to be nearly insoluble (қorg=0.02). However, this is not unambigious and қorg=0.2 is found as an upper limit at 0.1% supersaturation.

Summer Job Listings.

ERIC Educational Resources Information Center

Winds of Change, 1995

1995-01-01

Lists summer positions offered by various public agencies, corporations, and universities for high school, college and graduate students. Positions include internships, employment, and cooperative educational opportunities. Includes a brief description, required prerequisites, deadline and requirements for application, and contact person. Some…

Summer programming in rural communities: unique challenges.

PubMed

Phillips, Ruthellen; Harper, Stacey; Gamble, Susan

2007-01-01

During the past several decades, child poverty rates have been higher in rural than in urban areas, and now 2.5 million children live in deep poverty in rural America. Studies indicate that poor children are most affected by the typical "summer slide." Summer programming has the ability to address the issues of academic loss, nutritional loss, and the lack of safe and constructive enrichment activities. However, poor rural communities face three major challenges in implementing summer programming: community resources, human capital, and accessibility. The success of Energy Express, a statewide award-winning six-week summer reading and nutrition program in West Virginia, documents strategies for overcoming the challenges faced by poor, rural communities in providing summer programs. Energy Express (1) uses community collaboration to augment resources and develop community ownership, (2) builds human capital and reverses the acknowledged brain drain by engaging college students and community volunteers in meaningful service, and (3) increases accessibility through creative transportation strategies. West Virginia University Extension Service, the outreach arm of the land-grant institution, partners with AmeriCorps, a national service program, and various state and local agencies and organizations to implement a program that produces robust results.

20 CFR 632.262 - Termination date for the summer program.

Code of Federal Regulations, 2011 CFR

2011-04-01

... 20 Employees' Benefits 3 2011-04-01 2011-04-01 false Termination date for the summer program. 632... INDIAN AND NATIVE AMERICAN EMPLOYMENT AND TRAINING PROGRAMS Summer Youth Employment and Training Programs § 632.262 Termination date for the summer program. Participants may not be enrolled in the summer...

20 CFR 632.262 - Termination date for the summer program.

Code of Federal Regulations, 2012 CFR

2012-04-01

... 20 Employees' Benefits 3 2012-04-01 2012-04-01 false Termination date for the summer program. 632... INDIAN AND NATIVE AMERICAN EMPLOYMENT AND TRAINING PROGRAMS Summer Youth Employment and Training Programs § 632.262 Termination date for the summer program. Participants may not be enrolled in the summer...

20 CFR 632.262 - Termination date for the summer program.

Code of Federal Regulations, 2010 CFR

2010-04-01

... 20 Employees' Benefits 3 2010-04-01 2010-04-01 false Termination date for the summer program. 632... INDIAN AND NATIVE AMERICAN EMPLOYMENT AND TRAINING PROGRAMS Summer Youth Employment and Training Programs § 632.262 Termination date for the summer program. Participants may not be enrolled in the summer...

50 CFR 648.101 - Summer flounder Annual Catch Target (ACT).

Code of Federal Regulations, 2013 CFR

2013-10-01

... 50 Wildlife and Fisheries 12 2013-10-01 2013-10-01 false Summer flounder Annual Catch Target (ACT... Management Measures for the Summer Flounder Fisheries § 648.101 Summer flounder Annual Catch Target (ACT). (a) The Summer Flounder Monitoring Committee shall identify and review the relevant sources of management...

50 CFR 648.101 - Summer flounder Annual Catch Target (ACT).

Code of Federal Regulations, 2014 CFR

2014-10-01

... 50 Wildlife and Fisheries 12 2014-10-01 2014-10-01 false Summer flounder Annual Catch Target (ACT... Management Measures for the Summer Flounder Fisheries § 648.101 Summer flounder Annual Catch Target (ACT). (a) The Summer Flounder Monitoring Committee shall identify and review the relevant sources of management...

50 CFR 648.101 - Summer flounder Annual Catch Target (ACT).

Code of Federal Regulations, 2012 CFR

2012-10-01

... 50 Wildlife and Fisheries 12 2012-10-01 2012-10-01 false Summer flounder Annual Catch Target (ACT... Management Measures for the Summer Flounder Fisheries § 648.101 Summer flounder Annual Catch Target (ACT). (a) The Summer Flounder Monitoring Committee shall identify and review the relevant sources of management...

Summer Versus School-Year Alcohol Use Among Mandated College Students.

PubMed

Miller, Mary Beth; Merrill, Jennifer E; Yurasek, Ali M; Mastroleo, Nadine R; Borsari, Brian

2016-01-01

Longitudinal research examining college students' alcohol use during the summer months, especially in at-risk individuals, is limited. The current study evaluated changes in mandated college students' alcohol use and related consequences over the summer. Participants (n = 305, 67% male) who had violated campus alcohol policy and were subsequently mandated to treatment completed follow-up assessments at 3, 6, and 9 months. For the majority of students, one of these follow-up assessments occurred over the summer. Hierarchical linear modeling was used to examine changes in alcohol use and related consequences during the school year and summer. Participants reported consuming significantly fewer drinks per occasion, reaching lower peak blood alcohol concentrations, and experiencing fewer alcohol-related consequences during the summer months. All outcomes were mediated by summer housing, indicating that summer influenced alcohol use indirectly through participants' tendency to live at home. Despite small but significant decreases in alcohol consumption and related consequences when living with a parent/guardian, mandated college students continue to exhibit risky drinking and consequences during the summer months. Given these findings, summer may be an appropriate time to implement prevention and intervention strategies with mandated and other at-risk populations.

Feasibility of Summer Employment of Teachers.

ERIC Educational Resources Information Center

Clark County School District, Las Vegas, NV.

A teacher staff of 21 was employed for 6 to 8 weeks during the summers of 1967, 1968, and 1969 at Virgin Valley, Nevada, with funding provided by the Elementary and Secondary Education Act (Title III). The purpose of the study was to determine the feasibility of summer employment for teachers by the school system. Project design called for 3…

Six for Summer: Professional Learning Opportunities

ERIC Educational Resources Information Center

Curran, Ben

2014-01-01

Teaching is and always has been a year-round job. Even when educators are not working during the summer months, they are always planning for the year ahead. This has not changed in the 21st century. In fact, teachers might work harder now than ever. While summer is the perfect time for teachers to relax and recharge their batteries, it also…

Ted Stevens Anchorage International Airport

Science.gov Websites

than 50 years, Ted Stevens Anchorage International Airport has played an integral role in the growth of System Forecasts Robust Tourism Growth for the Summer Season Press Release 4-24-18 offside link Sun Cargo Growth 2017 Press Release 2-12-18 offsite link ANC 15-33 Project Website offsite link May 2018

Insights into an Award-Winning Summer Internship Program: The First Six Years.

PubMed

Kashou, Anthony; Durairajanayagam, Damayanthi; Agarwal, Ashok

2016-04-01

Since its inception in 2008, the American Center for Reproductive Medicine's summer internship program in reproductive research and writing has trained 114 students from 23 states within the United States and 10 countries worldwide. Its fundamental goal is to inspire pre-medical and medical students to embrace a career as a physician-scientist. During this intensive course, established scientists and clinicians train interns in the essential principles and fundamental concepts of bench research and scientific writing. Over the first six years (2008~2013), interns have collectively published 98 research articles and performed 12 bench research projects on current and emerging topics in reproductive medicine. Interns have also developed and honed valuable soft skills including time management, communication and presentation skills, as well as life values, which all enhance personal and professional satisfaction. Program graduates are able to recognize the value of medical research and its potential to impact patient care and gain insight into their own career pathway. Between 2011 and 2014, the internship program was thrice awarded a Scholarship in Teaching Award by Case Western Reserve School of Medicine for its innovative teaching approach and positive impact on medical education and student careers. This report highlights the demographics, logistics, implementation, feedback, and results of the first six years of the American Center for Reproductive Medicine's summer internship program at Cleveland Clinic (Cleveland, OH, USA). This may be helpful to other research and academic institutions considering implementing a similar program. In addition, it creates awareness among potential physician-scientists of what the world of research has to offer in both scientific writing and bench research. Finally, it may stimulate further discussion regarding narrowing the gap between physicians and scientists and refinement of the current program.

Insights into an Award-Winning Summer Internship Program: The First Six Years

PubMed Central

Kashou, Anthony; Durairajanayagam, Damayanthi

2016-01-01

Since its inception in 2008, the American Center for Reproductive Medicine's summer internship program in reproductive research and writing has trained 114 students from 23 states within the United States and 10 countries worldwide. Its fundamental goal is to inspire pre-medical and medical students to embrace a career as a physician-scientist. During this intensive course, established scientists and clinicians train interns in the essential principles and fundamental concepts of bench research and scientific writing. Over the first six years (2008~2013), interns have collectively published 98 research articles and performed 12 bench research projects on current and emerging topics in reproductive medicine. Interns have also developed and honed valuable soft skills including time management, communication and presentation skills, as well as life values, which all enhance personal and professional satisfaction. Program graduates are able to recognize the value of medical research and its potential to impact patient care and gain insight into their own career pathway. Between 2011 and 2014, the internship program was thrice awarded a Scholarship in Teaching Award by Case Western Reserve School of Medicine for its innovative teaching approach and positive impact on medical education and student careers. This report highlights the demographics, logistics, implementation, feedback, and results of the first six years of the American Center for Reproductive Medicine's summer internship program at Cleveland Clinic (Cleveland, OH, USA). This may be helpful to other research and academic institutions considering implementing a similar program. In addition, it creates awareness among potential physician-scientists of what the world of research has to offer in both scientific writing and bench research. Finally, it may stimulate further discussion regarding narrowing the gap between physicians and scientists and refinement of the current program. PMID:27169124

The use of early summer mosquito surveillance to predict late summer West Nile virus activity

USGS Publications Warehouse

Ginsberg, Howard S.; Rochlin, Ilia; Campbell, Scott R.

2010-01-01

Utility of early-season mosquito surveillance to predict West Nile virus activity in late summer was assessed in Suffolk County, NY. Dry ice-baited CDC miniature light traps paired with gravid traps were set weekly. Maximum-likelihood estimates of WNV positivity, minimum infection rates, and % positive pools were generally well correlated. However, positivity in gravid traps was not correlated with positivity in CDC light traps. The best early-season predictors of WNV activity in late summer (estimated using maximum-likelihood estimates of Culex positivity in August and September) were early date of first positive pool, low numbers of mosquitoes in July, and low numbers of mosquito species in July. These results suggest that early-season entomological samples can be used to predict WNV activity later in the summer, when most human cases are acquired. Additional research is needed to establish which surveillance variables are most predictive and to characterize the reliability of the predictions.

45 CFR 2400.51 - Summer Institute accreditation.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 45 Public Welfare 4 2010-10-01 2010-10-01 false Summer Institute accreditation. 2400.51 Section 2400.51 Public Welfare Regulations Relating to Public Welfare (Continued) JAMES MADISON MEMORIAL FELLOWSHIP FOUNDATION FELLOWSHIP PROGRAM REQUIREMENTS Graduate Study § 2400.51 Summer Institute accreditation...

45 CFR 2400.51 - Summer Institute accreditation.

Code of Federal Regulations, 2011 CFR

2011-10-01

... 45 Public Welfare 4 2011-10-01 2011-10-01 false Summer Institute accreditation. 2400.51 Section 2400.51 Public Welfare Regulations Relating to Public Welfare (Continued) JAMES MADISON MEMORIAL FELLOWSHIP FOUNDATION FELLOWSHIP PROGRAM REQUIREMENTS Graduate Study § 2400.51 Summer Institute accreditation...

Report to DHS on Summer Internship 2006

DOE Office of Scientific and Technical Information (OSTI.GOV)

Beckwith, R H

2006-07-26

This summer I worked at Lawrence Livermore National Laboratory in a bioforensics collection and extraction research group under David Camp. The group is involved with researching efficiencies of various methods for collecting bioforensic evidence from crime scenes. The different methods under examination are a wipe, swab, HVAC filter and a vacuum. The vacuum is something that has particularly gone uncharacterized. My time was spent mostly on modeling and calculations work, but at the end of the summer I completed my internship with a few experiments to supplement my calculations. I had two major projects this summer. My first major projectmore » this summer involved fluid mechanics modeling of collection and extraction situations. This work examines different fluid dynamic models for the case of a micron spore attached to a fiber. The second project I was involved with was a statistical analysis of the different sampling techniques.« less

Summer Session: A Time for Innovation

NASA Astrophysics Data System (ADS)

Mola, Monty

2013-05-01

Summer is almost here (at least for those of us who teach semesters). Many of us are taking a well-deserved break to spend time with our families, conduct research, travel, and myriad other activities. Some of us, however, will be teaching summer school. For those of us lucky enough to be teaching this summer, we have one suggestion: Be bold! Summer is the ideal time to try something new with your teaching. We have known for some time that alternative pedagogies and engaging teaching strategies can be more effective than traditional lectures as student learning environments. However, even with headlines in The Washington Post proclaiming that the lecture is dead,2 inroads of physics education research-based curricula have been slow to diffuse into the classrooms for the greater population of college physics instructors.3 Many instructors of traditional physics courses see the use of research-based instructional strategies (RBIS) as desirable but risky and time consuming.3 Assuming a traditional physics course structure, both the where and the when each component takes place can also limit the types of engaging pedagogies used.4

IASI carbon monoxide validation over the Arctic during POLARCAT spring and summer campaigns

NASA Astrophysics Data System (ADS)

Pommier, M.; Law, K. S.; Clerbaux, C.; Turquety, S.; Hurtmans, D.; Hadji-Lazaro, J.; Coheur, P.-F.; Schlager, H.; Ancellet, G.; Paris, J.-D.; Nédélec, P.; Diskin, G. S.; Podolske, J. R.; Holloway, J. S.; Bernath, P.

2010-06-01

In this paper, we provide a detailed comparison between carbon monoxide (CO) data measured by the Infrared Atmospheric Sounding Interferometer (IASI)/METOP and aircraft measurements over the Arctic. The CO measurements were obtained during North American campaigns (NASA ARCTAS and NOAA ARCPAC) and European campaigns (POLARCAT-France, POLARCAT-GRACE and YAK-AEROSIB) as part of the International Polar Year (IPY) in spring and summer 2008. During the campaigns different air masses were sampled including clean air, polluted plumes originating from anthropogenic sources in Europe, Asia and North America, and forest fire plumes originating from Siberia and Canada. CO-rich plumes following different transport pathways were captured well by the IASI instrument, illustrated for example by a transport event over the North Pole from Asia on 9 July 2008. The comparison between the IASI CO profiles and aircraft data was achieved by first completing the latter for higher altitudes using a latitudinally dependent climatology of ACE-FTS satellite CO profiles (2004-2009) and by subsequently smoothing the resulting full profiles by the IASI averaging kernels. Proceeding this way, the IASI profiles were shown to be in good agreement with smoothed in situ profiles (with a difference of about 10 ppbv) in spring. In summer, the IASI profiles were higher than the smoothed in situ profiles below 8 km, for all polluted cases. Correlations between IASI and combination ACE-FTS/aircraft derived total columns varied from 0.15 to 0.74 in spring and 0.26 to 0.84 in summer, with better results over the sea in spring (0.73) and over the land in summer (0.69).

Resonance Raman imaging for detecting and monitoring molecular pathological changes in human brain tumors related to Warburg effect

NASA Astrophysics Data System (ADS)

Zhou, Yan; Liu, Cheng-hui; Zhu, Ke; Zhang, Chunyuan; Yang, Yang; Yu, Xinguang; Hu, Hailong; Cheng, Gangge; Wu, Binlin; Shi, Lingyan; Alfano, Robert R.

2018-02-01

The goal of the research is to determine the prognostic molecular pathological changes in components and composition, for human brain glioma gradings in comparison with normal tissues in three-dimensional Raman imaging profiles by visible Resonance Raman (VRR) imaging. VRR images from twenty-five specimens including three healthy tissues, one normal control, and twenty-one glioma tissues of grades II, II-III and III-IV with histology examination were measured and investigated using WITec300R confocal micro Raman imaging system with laser excitation of 532nm. Two-dimensional RR spectral mappings performed in 20μm x 20μm generated 400 images which integrated the intensity of the specific biochemical bonds as the third dimension. The three-dimension (3D) map demonstrated the spatial distributions of three selected sets of RR spectra of molecular biomarkers, and revealed significant differences in the spectra between normal and glioma tissues of different grades due to the composition changes in key molimageecules. These RR molecular spectral fingerprints have displayed: a clear enhancement of RR vibrational modes at 1129-1131cm-1 and 2934cm-1 which are supposed to be arising from lipoproteins; evident decreased RR vibrational modes at 1442cm-1 and 2854cm-1 which are from saturated fatty acids bonds in all-grades of glioma brain tissues compared with normal tissues; and the enhanced RR spectral modes of 1129 cm-1 and 2938cm-1 which suggest contribution from lactate. These findings may provide a novel proof for anaerobic glycolysis metabolic process in brain glioma cancer tissues that has been explained by Warburg effects.

Science Skills Boot Camp Gets Interns Ready for Research | Poster

Cancer.gov

By Ashley DeVine, Staff Writer Summer interns learned how to read a scientific paper, present a poster, maintain a laboratory notebook, and much more, at the Science Skills Boot Camp in June. “It was a great experience, and it was a great opportunity to meet some of the other interns also working on the campus,” said Alyssa Klein, a Werner H. Kirsten student intern in the

Influences of spring-to-summer sea surface temperatures over different Indian Ocean domains on the Asian summer monsoon

NASA Astrophysics Data System (ADS)

Li, Zhenning; Yang, Song

2017-11-01

The influences of spring-to-summer sea surface temperature (SST) anomalies in different domains of the Indian Ocean (IO) on the Asian summer monsoon are investigated by conducting a series of numerical experiments using the NCAR CAM4 model. It is found that, to a certain extent, the springtime IO SST anomalies can persist to the summer season. The spring-to-summer IO SST anomalies associated with the IO basin warming mode are strongly linked to the summer climate over Asia, especially the South Asian monsoon (SAM) and the East Asian monsoon. Among this connection, the warming of tropical IO plays the most critical role, and the warming of southern IO is important for monsoon variation and prediction prior to the full development of the monsoon. The atmospheric response to IO basin wide warming is similar with that to tropical IO warming. The influence of northern IO warming on the SAM, however, is opposite to the effect of southern IO warming. Meanwhile, the discrepancies between the results from idealized SST forcing simulations and observations, especially for the southern IO, reveal that the dominant role of air-sea interaction in the monsoon-IO coupled system cannot be ignored. Moreover, the springtime northern IO warming seems to favor an early onset or a stronger persistence of the SAM.

Think Summer: Early Planning, Teacher Support Boost Summer Learning Programs

ERIC Educational Resources Information Center

Browne, Daniel

2013-01-01

A fundamental problem that continues to plague educators is the achievement gap between low-income and higher-income students. In the ongoing search for solutions, one of the more promising approaches is expanding opportunities for learning, particularly in the summer. This article describes a project funded by The Wallace Foundation that offers…

Summer Versus School-Year Alcohol Use Among Mandated College Students

PubMed Central

Miller, Mary Beth; Merrill, Jennifer E.; Yurasek, Ali M.; Mastroleo, Nadine R.; Borsari, Brian

2016-01-01

Objective: Longitudinal research examining college students’ alcohol use during the summer months, especially in at-risk individuals, is limited. The current study evaluated changes in mandated college students’ alcohol use and related consequences over the summer. Method: Participants (n = 305, 67% male) who had violated campus alcohol policy and were subsequently mandated to treatment completed follow-up assessments at 3, 6, and 9 months. For the majority of students, one of these follow-up assessments occurred over the summer. Hierarchical linear modeling was used to examine changes in alcohol use and related consequences during the school year and summer. Results: Participants reported consuming significantly fewer drinks per occasion, reaching lower peak blood alcohol concentrations, and experiencing fewer alcohol-related consequences during the summer months. All outcomes were mediated by summer housing, indicating that summer influenced alcohol use indirectly through participants’ tendency to live at home. Conclusions: Despite small but significant decreases in alcohol consumption and related consequences when living with a parent/guardian, mandated college students continue to exhibit risky drinking and consequences during the summer months. Given these findings, summer may be an appropriate time to implement prevention and intervention strategies with mandated and other at-risk populations. PMID:26751354

46 CFR 45.53 - Summer freeboard.

Code of Federal Regulations, 2011 CFR

2011-10-01

... summer for a type A vessel is F in the following formula modified by the corrections in this subpart: F (inches)=10.2×P 1×D where P 1 is defined in § 45.55 and D is the depth for freeboard in feet. (b) Except as required in paragraph (c) of this section, the minimum freeboard in summer for a type B vessel is...

46 CFR 45.53 - Summer freeboard.

Code of Federal Regulations, 2010 CFR

2010-10-01

... summer for a type A vessel is F in the following formula modified by the corrections in this subpart: F (inches)=10.2×P 1×D where P 1 is defined in § 45.55 and D is the depth for freeboard in feet. (b) Except as required in paragraph (c) of this section, the minimum freeboard in summer for a type B vessel is...

1998 Complex Systems Summer School

DOE Office of Scientific and Technical Information (OSTI.GOV)

NONE

1998-12-15

For the past eleven years a group of institutes, centers, and universities throughout the country have sponsored a summer school in Santa Fe, New Mexico as part of an interdisciplinary effort to promote the understanding of complex systems. The goal of these summer schools is to provide graduate students, postdoctoral fellows and active research scientists with an introduction to the study of complex behavior in mathematical, physical, and living systems. The Center for Nonlinear Studies supported the eleventh in this series of highly successful schools in Santa Fe in June, 1998.

IASI carbon monoxide validation over the Arctic during POLARCAT spring and summer campaigns

NASA Astrophysics Data System (ADS)

Pommier, M.; Law, K. S.; Clerbaux, C.; Turquety, S.; Hurtmans, D.; Hadji-Lazaro, J.; Coheur, P.-F.; Schlager, H.; Ancellet, G.; Paris, J.-D.; Nédélec, P.; Diskin, G. S.; Podolske, J. R.; Holloway, J. S.; Bernath, P.

2010-11-01

In this paper, we provide a detailed comparison between carbon monoxide (CO) data measured by the Infrared Atmospheric Sounding Interferometer (IASI)/MetOp and aircraft observations over the Arctic. The CO measurements were obtained during North American (NASA ARCTAS and NOAA ARCPAC) and European campaigns (POLARCAT-France, POLARCAT-GRACE and YAK-AEROSIB) as part of the International Polar Year (IPY) POLARCAT activity in spring and summer 2008. During the campaigns different air masses were sampled including clean air, polluted plumes originating from anthropogenic sources in Europe, Asia and North America, and forest fire plumes originating from Siberia and Canada. The paper illustrates that CO-rich plumes following different transport pathways were well captured by the IASI instrument, in particular due to the high spatial coverage of IASI. The comparison between IASI CO total columns, 0-5 km partial columns and profiles with collocated aircraft data was achieved by taking into account the different sensitivity and geometry of the sounding instruments. A detailed analysis is provided and the agreement is discussed in terms of information content and surface properties at the location of the observations. For profiles, the data were found to be in good agreement in spring with differences lower than 17%, whereas in summer the difference can reach 20% for IASI profiles below 8 km for polluted cases. For total columns the correlation coefficients ranged from 0.15 to 0.74 (from 0.47 to 0.77 for partial columns) in spring and from 0.26 to 0.84 (from 0.66 to 0.88 for partial columns) in summer. A better agreement is seen over the sea in spring (0.73 for total column and 0.78 for partial column) and over the land in summer (0.69 for total columns and 0.81 for partial columns). The IASI vertical sensitivity was better over land than over sea, and better over land than over sea ice and snow allowing a higher potential to detect CO vertical distribution during summer.

Seasonal Variations in the Number of the Summer Shamal Days in the Southern Arabian Gulf

NASA Astrophysics Data System (ADS)

Saleh Almehrezi, Ali Saif Ali; Shapiro, Georgy; Thain, Richard

2014-05-01

effect on the region. The high number of Summer Shamal days is associated with the strong summer monsoon or eastward-shift of the Azores High over land. Conversely, the low number of Summer Shamal days is associated with a westward-shift of the Azores High over the Atlantic or weak summer monsoon. References Al Aali, H. (2011); Collected wind data, over a thirty year period (1981 to 2010), from Bahrain Bahrain International airport wind data set, submitted by official communication using official email Hhalaali@caa.gov.bh. Govinda, R., Al-Sulaiti, M., Al-Mulla, A., (2001); Winter Shamals in Qatar, Arabian Gulf, Weather, Vol 56, No.12, PP 444-451. Govinda R., Hatwar, H., Al-Sulaiti, M., Al-Mulla, A., (2003); Summer Shamal over the Arabian Gulf, Weather, Vol 58, No.12, PP 471-477. Nazemosadat, M., Samani, N., Barry, D., and Niko, M., (2006); ENSO forcing on climate change in Iran: Precipitation analysis, Iranian Journal of Science & Technology, Transaction B, Engineering, Vol. 30, No B4, p. 555-565 NCEP, 2013; Monthly/Seasonal Climate Composites < http://www.esrl.noaa.gov/psd/cgi-bin/data/composites/printpage.pl >

Summer Roof Maintenance.

ERIC Educational Resources Information Center

Liscum, Curtis L.

1999-01-01

Presents the items to review in roofing maintenance to prepare for the impact of summer, including checking drainage, roof-field surface and membrane, flashings, sheet metal, and rooftop equipment, such as skylights and penthouses. A list of roofing facts facility managers should know are highlighted. (GR)

Future summer mega-heatwave and record-breaking temperatures in a warmer France climate

NASA Astrophysics Data System (ADS)

Bador, Margot; Terray, Laurent; Boé, Julien; Somot, Samuel; Alias, Antoinette; Gibelin, Anne-Laure; Dubuisson, Brigitte

2017-07-01

This study focuses on future very hot summers associated with severe heatwaves and record-breaking temperatures in France. Daily temperature observations and a pair of historical and scenario (greenhouse gas radiative concentration pathway 8.5) simulations with the high-resolution (∼12.5 km) ALADIN regional climate model provide a robust framework to examine the spatial distribution of these extreme events and their 21st century evolution. Five regions are identified with an extreme event spatial clustering algorithm applied to observed temperatures. They are used to diagnose the 21st century heatwave spatial patterns. In the 2070s, we find a simulated mega-heatwave as severe as the 2003 observed heatwave relative to its contemporaneous climate. A 20-member initial condition ensemble is used to assess the sensitivity of this future heatwave to the internal variability in the regional climate model and to pre-existing land surface conditions. Even in a much warmer and drier climate in France, late spring dry land conditions may lead to a significant amplification of summer extreme temperatures and heatwave intensity through limitations in evapotranspiration. By 2100, the increase in summer temperature maxima exhibits a range from 6 °C to almost 13 °C in the five regions in France, relative to historical maxima. These projections are comparable with the estimates given by a large number of global climate models.

Global strategies targeting the recruitment crisis in psychiatry: the Doctors Academy Future Excellence International Medical Summer School.

PubMed

Hankir, Ahmed; Zaman, Rashid

2015-09-01

The World Health Organization has identified a chronic shortage of psychiatrists worldwide whereas the demand for mental health services is on the rise. Indeed mental health problems are projected to be a leading cause of morbidity by 2020 according to the Global Burden of Disease study. Bhugra et al, under the auspices of the Royal College of Psychiatrists and the World Psychiatry Association, spearheaded an international study across 22 countries and identified myriad factors that can influence career choices at pre-medical school, medical school and postgraduate levels. The enthusiasm and passion of mental health educators and the quality of psychiatry placements were identified as factors that can attract medical and students and graduates to a career in psychiatry. The Future Excellence International Medical Summer School (FEIMSS) is a 5-day event for medical students held yearly in Manchester, UK. FEIMSS is the largest event of its kind in the world; the 2013 cohort was comprised of 244 students from 40 countries representing 80 universities. To improve the image of psychiatrists and the perception of psychiatry in general with 2 brief contact-based lectures from a consultant and an early-career psychiatrist. The lectures incorporated references to the humanities (literature, poetry, history, film, drama and art). A mixed-methods study was conducted. Paper evaluation forms were hand-distributed to participants who attended the psychiatry talks. Items to constructs relevant to the talks were on a Likert-type scale. Participants were given the choice of anonymity. There was space for free-text comments which were subjected to thematic analyses. 25/25 of the participants responded (response rate 100%). The heterogeneous sample was comprised of participants representing 11 countries from Japan to Kosovo. The written feedback was exceptionally positive. For the, 'The psychiatry talks were interesting' and, 'Attending FEIMMS improved my understanding and respect

Salt appetite is not increased in summer heat.

PubMed

Leshem, Micah

2017-01-01

We tested the hypothesis that salt appetite increases in summer heat due to increased sodium loss due to increased drinking and perspiration. A test battery in the same sample of healthy young people tested in summer and winter revealed no seasonal differences in salt appetite (or fluid intake) despite a 10 °C rise in mean environmental temperature. Unexpectedly, sweet preference is reduced in summer. Copyright © 2016 Elsevier Ltd. All rights reserved.

Next Generation Summer School

NASA Astrophysics Data System (ADS)

Eugenia, Marcu

2013-04-01

On 21.06.2010 the "Next Generation" Summer School has opened the doors for its first students. They were introduced in the astronomy world by astronomical observations, astronomy and radio-astronomy lectures, laboratory projects meant to initiate them into modern radio astronomy and radio communications. The didactic programme was structure as fallowing: 1) Astronomical elements from the visible spectrum (lectures + practical projects) 2) Radio astronomy elements (lectures + practical projects) 3) Radio communication base (didactic- recreative games) The students and professors accommodation was at the Agroturistic Pension "Popasul Iancului" situated at 800m from the Marisel Observatory. First day (summer solstice day) began with a practical activity: determination of the meridian by measurements of the shadow (the direction of one vertical alignment, when it has the smallest length). The experiment is very instructive and interesting because combines notions of physics, spatial geometry and basic astronomy elements. Next day the activities took place in four stages: the students processed the experimental data obtained on first day (on sheets of millimetre paper they represented the length of the shadow alignments according the time), each team realised its own sun quadrant, point were given considering the design and functionality of these quadrant, the four teams had to mimic important constellations on carton boards with phosphorescent sticky stars and the students, accompanied by the professors took a hiking trip to the surroundings, marking the interest point coordinates, using a GPS to establish the geographical coronations and at the end of the day the students realised a small map of central Marisel area based on the GPS data. On the third day, the students were introduced to basic notions of radio astronomy, the principal categories of artificial Earth satellites: low orbit satellites (LEO), Medium orbit satellites (MEO) and geostationary satellites (GEO

7 CFR 250.62 - Summer Food Service Program (SFSP).

Code of Federal Regulations, 2013 CFR

2013-01-01

... 7 Agriculture 4 2013-01-01 2013-01-01 false Summer Food Service Program (SFSP). 250.62 Section 250... Program (NSLP) and Other Child Nutrition Programs § 250.62 Summer Food Service Program (SFSP). (a... meals to needy children primarily in the summer months, in their nonprofit food service programs...

7 CFR 250.62 - Summer Food Service Program (SFSP).

Code of Federal Regulations, 2012 CFR

2012-01-01

... 7 Agriculture 4 2012-01-01 2012-01-01 false Summer Food Service Program (SFSP). 250.62 Section 250... Program (NSLP) and Other Child Nutrition Programs § 250.62 Summer Food Service Program (SFSP). (a... meals to needy children primarily in the summer months, in their nonprofit food service programs...

7 CFR 250.62 - Summer Food Service Program (SFSP).

Code of Federal Regulations, 2011 CFR

2011-01-01

... 7 Agriculture 4 2011-01-01 2011-01-01 false Summer Food Service Program (SFSP). 250.62 Section 250... Program (NSLP) and Other Child Nutrition Programs § 250.62 Summer Food Service Program (SFSP). (a... meals to needy children primarily in the summer months, in their nonprofit food service programs...

Interdecadal variations of East Asian summer monsoon northward propagation and influences on summer precipitation over East China

NASA Astrophysics Data System (ADS)

Jiang, Z.; Yang, S.; He, J.; Li, J.; Liang, J.

2008-08-01

The interdecadal variation of northward propagation of the East Asian Summer Monsoon (EASM) and summer precipitation in East China have been investigated using daily surface rainfall from a dense rain gauge network in China for 1957 2001, National Center for Environmental Prediction/National Center for Atmospheric Research (NCEP/NCAR) reanalysis, European Center for Medium-Range Weather Forecast (ECMWF) reanalysis, and Global Mean Sea Level Pressure Dataset (GMSLP2) from Climatic Research Unit (CRU). Results in general show a consistent agreement on the interdecadal variability of EASM northward propagations. However, it appears that the interdecadal variation is stronger in NCEP than in ECMWF and CRU datasets. A newly defined normalized precipitation index (NPI), a 5-day running mean rainfall normalized with its standard deviation, clearly depicts the characteristics of summer rainbelt activities in East China in terms of jumps and durations during its northward propagations. The EASM northward propagation shows a prominent interdecadal variation. EASM before late 1970s had a rapid northward advance and a northern edge beyond its normal position. As a result, more summer rainfall occurred for the North China rainy season, Huaihe-River Mei-Yu, and South China Mei-Yu. In contrast, EASM after late 1970s had a slow northward movement and a northern edge located south of its normal position. Less summer precipitation occurred in East China except in Yangtze River basin. The EASM northernmost position (ENP), northernmost intensity (ENI), and EASM have a complex and good relationship at interdecadal timescales. They have significant influences on interdecadal variation of the large-scale precipitation anomalies in East China.

Summer birth and deficit schizophrenia: Cantabria, Spain.

PubMed

Kirkpatrick, Brian; Herrera Castanedo, Sara; Vazquez-Barquero, Jose L

2002-08-01

An association between deficit schizophrenia and summer birth has previously been reported. The authors attempted to replicate this association in a population-based study of incident cases of psychosis in the autonomous region of Cantabria, in northern Spain. Schizophrenia patients were categorized into deficit (N = 22) and nondeficit (N = 55) groups, and the pattern in the two groups was compared. After accounting for the variance due to disorganization, hallucinations and delusions, and demographic variables, deficit schizophrenia had a significant association with summer birth; this association did not depend on a single definition of summer. For instance, among the deficit patients, 59% were born from May to August, in contrast to 18% of nondeficit patients and 34% of the general population. These results confirm the association between summer birth in the Northern Hemisphere and deficit as opposed to nondeficit schizophrenia. The existence of a different risk factor for the two groups suggests a difference in etiology and pathophysiology.

Skilful Seasonal Predictions of Summer European Rainfall

NASA Astrophysics Data System (ADS)

Dunstone, Nick; Smith, Doug; Scaife, Adam; Hermanson, Leon; Fereday, David; O'Reilly, Chris; Stirling, Alison; Eade, Rosie; Gordon, Margaret; MacLachlan, Craig; Woollings, Tim; Sheen, Katy; Belcher, Stephen

2018-04-01

Year-to-year variability in Northern European summer rainfall has profound societal and economic impacts; however, current seasonal forecast systems show no significant forecast skill. Here we show that skillful predictions are possible (r 0.5, p < 0.001) using the latest high-resolution Met Office near-term prediction system over 1960-2017. The model predictions capture both low-frequency changes (e.g., wet summers 2007-2012) and some of the large individual events (e.g., dry summer 1976). Skill is linked to predictable North Atlantic sea surface temperature variability changing the supply of water vapor into Northern Europe and so modulating convective rainfall. However, dynamical circulation variability is not well predicted in general—although some interannual skill is found. Due to the weak amplitude of the forced model signal (likely caused by missing or weak model responses), very large ensembles (>80 members) are required for skillful predictions. This work is promising for the development of European summer rainfall climate services.

The Minneapolis Heart Institute Foundation Summer Research Internship Program: the benefits of preprofessional experience for prospective physicians.

PubMed

Willenbring, Benjamin D; McKee, Katherine C; Wilson, Betsy V; Henry, Timothy D

2008-08-01

There is a distinct shortage of preprofessional opportunities for undergraduate premedical students. During the last 7 summers, the Minneapolis Heart Institute Foundation Summer Research Internship Program has exposed interested students to cardiology and clinical research. The goals of the internship program are threefold: to bring students in contact with the medical profession, to offer experiences in the various disciplines of cardiology, and to introduce students to clinical research. The success of the program can be measured by its influence on participants' academic pursuits and scholarly contributions. Of the 65 internship alumni, 52 are studying to become physicians and most of the others are in health-related fields. Interns have also contributed abstracts and manuscripts to peer-reviewed journals and presented their research at major conferences.

1. SUMMER STREET BRIDGE. DRAW SPAN MOVES TOWARD VIEWER ON ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

1. SUMMER STREET BRIDGE. DRAW SPAN MOVES TOWARD VIEWER ON TRACKS VISIBLE AT CENTER OF PHOTOGRAPH. - Summer Street Retractile Bridge, Spanning Fort Point Channel at Summer Street, Boston, Suffolk County, MA

Lasting Consequences of the Summer Learning Gap

ERIC Educational Resources Information Center

Alexander, Karl L.; Entwisle, Doris R.; Olson, Linda Steffel

2007-01-01

Prior research has demonstrated that summer learning rooted in family and community influences widens the achievement gap across social lines, while schooling offsets those family and community influences. In this article, we examine the long-term educational consequences of summer learning differences by family socioeconomic level. Using data…

South Polar Cap, Summer 2000

NASA Technical Reports Server (NTRS)

2000-01-01

This is the south polar cap of Mars as it appeared to the Mars Global Surveyor (MGS) Mars Orbiter Camera (MOC) on April 17, 2000. In winter and early spring, this entire scene would be covered by frost. In summer, the cap shrinks to its minimum size, as shown here. Even though it is summer, observations made by the Viking orbiters in the 1970s showed that the south polar cap remains cold enough that the polar frost (seen here as white) consists of carbon dioxide. Carbon dioxide freezes at temperatures around -125o C (-193o F). Mid-summer afternoon sunlight illuminates this scene from the upper left from about 11.2o above the horizon. Soon the cap will experience sunsets; by June 2000, this pole will be in autumn, and the area covered by frost will begin to grow. Winter will return to the south polar region in December 2000. The polar cap from left to right is about 420 km (260 mi) across.

[Effects of tillage at pre-planting of winter wheat and summer maize on leaf senescence of summer maize].

PubMed

Li, Xia; Zhang, Ji-wang; Ren, Bai-zhao; Fan, Xia; Dong, Shu-ting; Liu, Peng; Zhao, Bin

2015-05-01

This study explored the effects of different tillage treatments at pre-planting winter wheat and summer maize on leaf senescence physiological characteristics of summer maize in double cropping system. Zhengdan 958 was used as experimental material. Three tillage treatments, including rotary tillage before winter wheat seeding and no-tillage before summer maize seeding (RN), mold- board plow before winter wheat seeding and no-tillage before summer maize seeding (MN), and moldboard plow before winter wheat seeding and rotary tillage before summer maize seeding (MR), were designed to determine the effects of different tillage treatments on leaf area (LA) , leaf area reduction, photosynthetic pigments content, superoxide dismutase (SOD), catalase (CAT) and peroxidase (POD) activities and malondialdehyde (MDA) content in ear leaves of summer maize after tasselling (VT). LA of MN and MR were higher than that of RN from VT to 40 days after tasseling (VT + 40) and LA reduction of MR was the highest after VT + 40. As for MR, MN and NT, the photosynthetic pigments content got the maximum value at 20 days after tasselling (VT + 20) and then decreased, following the change of unimodal curve. At VT + 20, the contents of chlorophyll a in MR and MN were increased by 11.4% and 9.7%, the contents of chlorophyll b in MR and MN were increased by 14.9% and 15.9%, compared with RN. The soluble protein content in ear leaves decreased following the growth process in all treatments, and that of MR and MN remained 11.5% and 24.4% higher than that of RN from VT to VT + 40. SOD, CAT and POD activities of three treatments got the maximum values at VT + 20 and then decreased, following the change of unimodal curve. MDA content increased following the growth process in all treatments and that of RN always remained at high levels. Grain yields of MN and MR were 24.0% and 30.6% greater than that of RN, respectively. Grain yield of MR was 5.2% higher than that of MN. In conclusion, the ability of

Cross-Cultural Competencies for the NASA International Internship Project

NASA Technical Reports Server (NTRS)

Niedbala, Elizabeth M.; Feinberg, Jessica

2017-01-01

One of the principles that NASA upholds is to cooperate with other nations to advance science, exploration, and discovery for all. Effective cooperation across cultures, however, requires a certain level of skill. A construct called cross-cultural competency (CCC) emphasizes that individuals are capable of acquiring skills that facilitate positive and cooperative interaction with people of another culture. While some aspects of CCC stem from stable individual traits such as personality (i.e., extraversion, tolerance for ambiguity), most components can be learned and strengthened over time (i.e., empathy, mindfulness, trust). Because CCC is such a vital part of international cooperation, this summer we will design a training program to cultivate these skills between student interns, their mentors, and the Ames community as a whole. First, we will research what specific competencies are valuable for anyone to have when working in an international setting. We will then design a series of activities, events, workshops, and discussions that target and strengthen those skills. Finally, we will use both qualitative and quantitative evaluation methods to measure the success of the pilot program. This summer, the current international student interns will serve as our trial population for the program, while our goal is to launch the full program in Fall 2017. Overall, we hope to contribute to NASAs mission of optimizing international collaboration for everyone involved.

Center for Computing Research Summer Research Proceedings 2015.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Bradley, Andrew Michael; Parks, Michael L.

2015-12-18

The Center for Computing Research (CCR) at Sandia National Laboratories organizes a summer student program each summer, in coordination with the Computer Science Research Institute (CSRI) and Cyber Engineering Research Institute (CERI).

Finding the Resources for Summer Learning Programs

ERIC Educational Resources Information Center

Sundius, M. Jane

2007-01-01

Research on summer learning losses has unambiguous implications for America: all children need learning opportunities in the summer. But how and when policymakers, educators, and youth service providers will fashion appropriate programming are far less clear. At the root of this problem is the need to vastly increase, stabilize, and coordinate…

Summer Camp of Mathematical Modeling in China

ERIC Educational Resources Information Center

Tian, Xiaoxi; Xie, Jinxing

2013-01-01

The Summer Camp of Mathematical Modeling in China is a recently created experience designed to further Chinese students' academic pursuits in mathematical modeling. Students are given more than three months to research on a mathematical modeling project. Researchers and teams with outstanding projects are invited to the Summer Camp to present…

1995 Summer Opportunities for American Indian Students.

ERIC Educational Resources Information Center

ORBIS Associates, Washington, DC.

This document contains information on summer academic programs offered to American Indian and Alaska Native junior high and high school students. Included are mathematics and science summer programs offered to high school students by the American Indian Science and Engineering Society at universities in Oklahoma, New Mexico, Wisconsin, Iowa,…

Super Summer Safari Manual: 1989 Summer Library Program. Bulletin No. 9240.

ERIC Educational Resources Information Center

Roeber, Jane A., Ed.

Based on the theme, "Super Summer Safari: Make Books Your Big Game," this manual describes library activities intended to stimulate family explorations of local and regional natural environments, of urban parks, and of agricultural settings. The manual is divided into 6 sections: (1) "Planning and Promoting Programs"; (2)…

I Know What You Did Last Summer

ERIC Educational Resources Information Center

Opalinski, Gail; Ellers, Sherry; Goodman, Amy

2004-01-01

This article describes the revised summer school program developed by the Anchorage (AK) School District for students who received poor grades in their core classes or low scores in the Alaska Benchmark Examinations or California Achievement Tests. More than 500 middle school students from the district spent five weeks during the summer honing…

Summer Leeside Rainfall Maxima over the Island of Hawaii

NASA Astrophysics Data System (ADS)

Huang, Y. F.; Chen, Y. L.

2016-12-01

The Kona area on the leeside in the island of Hawaii has distinctive summer rainfall maxima. The primary physical processes for the summer rainfall maxima in Kona are analyzed by comparing it with the winter rainfall. The annual and diurnal cycles there are investigated by employing the Fifth-generation Pennsylvania State University-NCAR Mesoscale Model coupled with the advanced land surface model from June 2004 and February 2010. During the summer, the nocturnal rainfall maximum adjacent to the Kona coast is larger than in winter because of the stronger, moister westerly reversed flow and offshore flow in summer. Comparisons between winter trade-wind days and winter mean show that the leeside Kona rainfall offshore in winter mainly occurs under trade-wind conditions. Moreover, the model results also attest to the impact of moisture content on the Kona leeside rainfall offshore. Comparisons between winter and summer trade-wind days indicate that upslope flows on the Kona slopes are stronger and the moisture content from the westerly reversed flow is higher in summer than in winter. The rainfall maximum on the lower Kona slopes is more pronounced in summer than in winter as a result of enhanced orographic lifting due to stronger upslope flow in the afternoon hours and the moister westerly reversed flow offshore, which merges with the upslope flow inland.

Second Multiflow Summer School on Turbulence

NASA Astrophysics Data System (ADS)

Jiménez, Javier

2016-04-01

Multiflow is a research program, funded by the European Research Council, whose goal is to improve our understanding of the multiscale dynamics of turbulence in fluids. Its second Summer School on Turbulence took place at the School of Aeronautics of the Technical University of Madrid from May 25 to June 26, 2015, with the goal of providing a meeting place for theoreticians, experimentalists and simulators, in which to develop and test new ideas on turbulence physics and structure. Around forty, mostly young, participants from twenty international groups met for five weeks of collaborative work, primarily using the computational data archived in the receiving institution but, in many cases, also contributing their own. Although the format included a few invited formal seminars and periodic plenary meetings, most of the work took place in small groups that, in many cases, changed their composition during the workshop. The papers in these proceedings reflect the results of the work of these groups which, in many cases, later continued in the form of new collaborations.

Report on the 2008 ISAGA Summer School

ERIC Educational Resources Information Center

van de Westelaken, Marleen

2011-01-01

This article reports on the 2008 ISAGA Summer School held in New Delhi (Gurgaon), India. This Summer School was hosted by the Institute for Integrated Learning in Management. Participants came from all over the world. This year's theme was "The Art and Science of Simulation and Gaming Design and Facilitation for Business and Management."

Successes and Challenges in the SAGE (Summer of Applied Geophysical Experience) REU Program

NASA Astrophysics Data System (ADS)

Braile, L. W.; Baldridge, W. S.; Pellerin, L.; Ferguson, J. F.; Bedrosian, P.; Biehler, S.; Jiracek, G. R.; Snelson, C. M.; Kelley, S.; McPhee, D.

2014-12-01

The SAGE program was initiated in 1983 to provide an applied geophysics research and education experience for students. Since 1983, 820 students have completed the SAGE summer program. Beginning in 1992, with funding from the NSF, SAGE has included an REU (Research Experience for Undergraduates) experience for selected undergraduate students from U.S. colleges and universities. Since 1992, 380 undergraduate REU students have completed the SAGE program. The four week, intensive, summer program is based in Santa Fe, New Mexico, and involves students in learning geophysical theory and applications; collection of geophysical field data in the northern Rio Grande Rift area; data processing, modeling and interpretation; and presentation (oral and written) of results of each student's research results. Students (undergraduates, graduates and professionals) and faculty are together on a school campus for the summer program. Successful strategies (developed over the years) of the program include teamwork experience, mentoring of REUs (by faculty and more senior students), cultural interchange due to students from many campuses across the U.S. and international graduate students, including industry visitors who work with the students and provide networking, a capstone experience of the summer program that includes all students making a "professional-meeting" style presentation of their research and submitting a written report, a follow-up workshop for the REU students to enhance and broaden their experience, and providing professional development for the REUs through oral or poster presentations and attendance at a professional meeting. Program challenges include obtaining funding from multiple sources; significant time investment in program management, reporting, and maintaining contact with our many funding sources and industry affiliates; and, despite significant efforts, limited success in recruiting racial and ethnic minority students to the program.

The Sixth Alumni Conference of the International Space University

NASA Technical Reports Server (NTRS)

Berry, Steve (Editor)

1997-01-01

These proceedings cover the sixth alumni conference of the International Space University, coordinated by the ISU U.S. Alumni Organization, which was held at Rice University in Houston, Texas, on July 11, 1997. The alumni conference gives graduates of the International Space University's interdisciplinary, international, and intercultural program a forum in which they may present and exchange technical ideas, and keep abreast of the wide variety of work in which the ever-growing body of alumni is engaged. The diversity that is characteristic of ISU is reflected in the subject matter of the papers published in this proceedings. This proceedings preserves the order of the alumni presentations given at the 1997 ISU Alumni Conference. As in previous years, a special effort was made to solicit papers with a strong connection to the two ISU 1997 Summer Session Program design projects: (1) Transfer of Technology, Spin-Offs, Spin-Ins; and (2) Strategies for the Exploration of Mars. Papers in the remaining ten sessions cover the departmental areas traditional to the ISU summer session program.

Scheduling for Public Service in International Operations

NASA Technical Reports Server (NTRS)

Brenner, M. A.

1972-01-01

The factors involved in scheduling airline services for international operations are discussed. Charts are presented to show the transatlantic pattern of flights for a typical airline during the summer and winter months. The operations of a domestic airline operating overseas and a foreign airline operating to the United States are compared.

Multi-model projections of Indian summer monsoon climate changes under A1B scenario

NASA Astrophysics Data System (ADS)

Niu, X.; Wang, S.; Tang, J.

2016-12-01

As part of the Regional Climate Model Intercomparison Project for Asia, the projections of Indian summer monsoon climate changes are constructed using three global climate models (GCMs) and seven regional climate models (RCMs) during 2041-2060 based on the Intergovernmental Panel on Climate Change A1B emission scenario. For the control climate of 1981-2000, most nested RCMs show advantage over the driving GCM of European Centre/Hamburg Fifth Generation (ECHAM5) in the temporal-spatial distributions of temperature and precipitation over Indian Peninsula. Following the driving GCM of ECHAM5, most nested RCMs produce advanced monsoon onset in the control climate. For future climate widespread summer warming is projected over Indian Peninsula by all climate models, with the Multi-RCMs ensemble mean (MME) temperature increasing of 1°C to 2.5°C and the maximum warming center located in northern Indian Peninsula. While for the precipitation, a large inter-model spread is projected by RCMs, with wetter condition in MME projections and significant increase over southern India. Driven by the same GCM, most RCMs project advanced monsoon onset while delayed onset is found in two Regional Climate Model (RegCM3) projections, indicating uncertainty can be expected in the Indian Summer Monsoon onset. All climate models except Conformal-Cubic Atmospheric Model with equal resolution (referred as CCAMP) and two RegCM3 models project stronger summer monsoon during 2041-2060. The disagreement in precipitation projections by RCMs indicates that the surface climate change on regional scale is not only dominated by the large-scale forcing which is provided by driving GCM but also sensitive to RCM' internal physics.

Did we see the 2011 summer heat wave coming?

NASA Astrophysics Data System (ADS)

Luo, Lifeng; Zhang, Yan

2012-05-01

A series of climate extreme events affected many parts of the US during 2011, including the severe drought in Texas, the spring tornado outbreak in the southern states, and the weeklong summer heat wave in the Central Plains. Successful prediction of these events can better inform and prepare the general public to cope with these extremes. In this study, we investigate the operational capability of the new NCEP Climate Forecast System (CFSv2) in predicting the 2011 summer heat wave. We found that starting from April 2011, the operational CFSv2 forecast consistently suggested an elevated probability of extremely hot days during the forthcoming summer over the Central Plains, and as the summer was approaching the forecast became more certain about the summer heat wave in its geographic location, intensity and timing. This study demonstrates the capability of the new seasonal forecast system and its potential usefulness in decision making process.

An Empirical Investigation of Student Motivations to Attend Summer School.

ERIC Educational Resources Information Center

Chandler, E. Wayne; Weller, Ralph B.

1995-01-01

A study of 166 business administration students attending summer school identified 4 factors influencing summer enrollment: academic issues (meeting grade standards or course requirements, etc.); desire to become more independent; financial issues; and traditional summer school motivations. Implications for marketing are discussed. (MSE)

Excess mortality during the warm summer of 2015 in Switzerland.

PubMed

Vicedo-Cabrera, Ana M; Ragettli, Martina S; Schindler, Christian; Röösli, Martin

2016-01-01

In Switzerland, summer 2015 was the second warmest summer for 150 years (after summer 2003). For summer 2003, a 6.9% excess mortality was estimated for Switzerland, which corresponded to 975 extra deaths. The impact of the heat in summer 2015 in Switzerland has not so far been evaluated. Daily age group-, gender- and region-specific all-cause excess mortality during summer (June-August) 2015 was estimated, based on predictions derived from quasi-Poisson regression models fitted to the daily mortality data for the 10 previous years. Estimates of excess mortality were derived for 1 June to 31 August, at national and regional level, as well as by month and for specific heat episodes identified in summer 2015 by use of seven different definitions. 804 excess deaths (5.4%, 95% confidence interval [CI] 3.0‒7.9%) were estimated for summer 2015 compared with previous summers, with the highest percentage obtained for July (11.6%, 95% CI 3.7‒19.4%). Seventy-seven percent of deaths occurred in people aged 75 years and older. Ticino (10.3%, 95% CI -1.8‒22.4%), Northwestern Switzerland (9.5%, 95% CI 2.7‒16.3%) and Espace Mittelland (8.9%, 95% CI 3.7‒14.1%) showed highest excess mortality during this three-month period, whereas fewer deaths than expected (-3.3%, 95% CI -9.2‒2.6%) were observed in Eastern Switzerland, the coldest region. The largest excess estimate of 23.7% was obtained during days when both maximum apparent and minimum night-time temperature reached extreme values (+32 and +20 °C, respectively), with 31.0% extra deaths for periods of three days or more. Heat during summer 2015 was associated with an increase in mortality in the warmer regions of Switzerland and it mainly affected older people. Estimates for 2015 were only a little lower compared to those of summer 2003, indicating that mitigation measures to prevent heat-related mortality in Switzerland have not become noticeably effective in the last 10 years.

2009 Summer Transportation Institute

DOT National Transportation Integrated Search

2009-09-01

The Western Transportation Institute hosted a two-week residential Summer Transportation Institute for sixteen high school students on the Montana State University campus from June 14 to June 26, 2009. Participants included Montana residents, one stu...

International program for Earth observations

NASA Technical Reports Server (NTRS)

1990-01-01

During the 1990 summer session of the International Space University, graduate students of many different countries and with various academic backgrounds carried out a design project that focused on how to meet the most pressing environmental information requirements of the 1990's. The International Program for Earth Observations (IPEO) is the result of the students labor. The IPEO report examines the legal and institutional, scientific, engineering and systems, financial and economic, and market development approaches needed to improve international earth observations and information systems to deal with environmental issues of global importance. The IPEO scenario is based on the production of a group of lightweight satellites to be used in global remote sensing programs. The design and function of the satellite is described in detail.

Reconstructing 800 years of summer temperatures in Scotland from tree rings

NASA Astrophysics Data System (ADS)

Rydval, Miloš; Loader, Neil J.; Gunnarson, Björn E.; Druckenbrod, Daniel L.; Linderholm, Hans W.; Moreton, Steven G.; Wood, Cheryl V.; Wilson, Rob

2017-11-01

This study presents a summer temperature reconstruction using Scots pine tree-ring chronologies for Scotland allowing the placement of current regional temperature changes in a longer-term context. `Living-tree' chronologies were extended using `subfossil' samples extracted from nearshore lake sediments resulting in a composite chronology >800 years in length. The North Cairngorms (NCAIRN) reconstruction was developed from a set of composite blue intensity high-pass and ring-width low-pass filtered chronologies with a range of detrending and disturbance correction procedures. Calibration against July-August mean temperature explains 56.4% of the instrumental data variance over 1866-2009 and is well verified. Spatial correlations reveal strong coherence with temperatures over the British Isles, parts of western Europe, southern Scandinavia and northern parts of the Iberian Peninsula. NCAIRN suggests that the recent summer-time warming in Scotland is likely not unique when compared to multi-decadal warm periods observed in the 1300s, 1500s, and 1730s, although trends before the mid-sixteenth century should be interpreted with some caution due to greater uncertainty. Prominent cold periods were identified from the sixteenth century until the early 1800s—agreeing with the so-called Little Ice Age observed in other tree-ring reconstructions from Europe—with the 1690s identified as the coldest decade in the record. The reconstruction shows a significant cooling response 1 year following volcanic eruptions although this result is sensitive to the datasets used to identify such events. In fact, the extreme cold (and warm) years observed in NCAIRN appear more related to internal forcing of the summer North Atlantic Oscillation.

Summer Training and Education Program (STEP). What Works Clearinghouse Intervention Report

ERIC Educational Resources Information Center

What Works Clearinghouse, 2009

2009-01-01

Summer Training and Education Program (STEP) is a summer employment, academic remediation, and life skills program intended to lower school dropout rates by reducing summer learning loss and preventing teen parenthood. The program is integrated into the federal summer jobs program and is offered during six-to-eight-week sessions in two…

Social and Economic Change in Southern Africa. Fulbright-Hays Summer Seminars Abroad Program, Summer 1991. [Curriculum Projects and Papers.

ERIC Educational Resources Information Center

Institute of International Education, New York, NY.

This document presents curriculum projects and papers written by U.S. teachers who traveled to countries in Southern Africa in the summer of 1991 as part of the Fulbright-Hays Summer Seminars Abroad Program. The included projects and papers are: "Through a Glass Darkly: The Enigmatic Educational System of Botswana" (Alan C. Howard);…

Literature Response Blogs and Summer Literacy: Exploring Summer Reading Setback and Reading Motivation of 3rd Grade Developing Readers

ERIC Educational Resources Information Center

Galdo, JoAnne Donnelly

2013-01-01

This study investigated the impact of Web 2.0-based literature response blogs on summer reading loss and student reading motivation. There is limited empirical research that connects summer reading and the use of social media as a means of maintaining reading levels of elementary aged students during out-of-school time. This study attempted to…

Management of diabetes at summer camps.

PubMed

Ciambra, Roberta; Locatelli, Chiara; Suprani, Tosca; Pocecco, Mauro

2005-01-01

We report our experience in the organization of diabetic children summer-camps since 1973. Guidelines for organization have been recently reported by the SIEDP (Società Italiana di Endocrinologia e Diabetologia Pediatrica). Our attention is focused on diabetes management at camp, organization and planning, medical staff composition and staff training, treatment of diabetes-related emergencies, written camp management plan, diabetes education and psychological issues at camp, prevention of possible risks, assessment of effectiveness of education in summer camps and research at camp.

2007 Summer Transportation Institute

DOT National Transportation Integrated Search

2007-11-01

The Western Transportation Institute hosted a two-week residential Summer Transportation Institute (STI) for high school students on the Montana State University campus from June 17 to June 29, 2007. Fifteen high school students from cities across Mo...

Safe summers: Adapting evidence-based injury prevention into a summer curriculum.

PubMed

Schaeffer, Melody; Cioni, Claire; Kozma, Nicole; Rains, Catherine; Todd, Greta

2017-11-01

Unintentional injury is the leading cause of death for those aged 0 years to 19 years. St. Louis Children's Hospital created Safety Land, a comprehensive injury prevention intervention which is provided during summer months. This program uses a life-size board game to teach safety education to children in ages 5 years to 11 years. The purpose of this study was to evaluate the effect of Safety Land on safety knowledge in children that participated in the intervention. St. Louis Children's Hospital identified ZIP codes with the highest use of the emergency room for injury. Daycares and summer camps within these ZIP codes were targeted for the Safety Land intervention. A multiple choice pretest and posttest survey was designed to measure knowledge change within program participants. Students were selected for testing based on site availably. Within these sites, a convenience sample of children was selected for pretesting and posttesting. Safety Land staff conducted the pretest a week before the intervention, and the posttest was administered the week after the intervention. A total knowledge score was calculated to determine overall knowledge change. Descriptive statistics and independent-samples t tests were conducted to determine statistical significance of change in knowledge (p < 0.05) for each question. Between May 2014 and August 2016, 3,866 children participated in Safety Land. A total of 310 children completed the pretest and 274 completed the posttest. Mean test scores increased from 66.7% to 85.1% and independent-samples t test of the total knowledge score was significant (p < 0.05) between pretest and posttest values. Findings suggest that this intervention is effective in increasing the knowledge of safety behaviors for children receiving the curriculum during the summer months. Further research should focus on long-term behavior changes in these youth.

Summer Events at the Scientific Library | Poster

Cancer.gov

Two exciting events are coming this summer from the Scientific Library—the annual Student Science Jeopardy Tournament and the Summer Video Series. This year, the 10th Annual Student Science Jeopardy Tournament will be held on Wednesday, July 20, beginning at 10 a.m. in the auditorium of Building 549. The event will also be streamed live to the Advanced Technology Research

Books for Summer Reading.

ERIC Educational Resources Information Center

Phi Delta Kappan, 1993

1993-01-01

Recommends fine fiction for summer reading, including Nadine Gordimer's "My Son's Story" (1991), Lillian Smith's "Strange Fruit" (1944), Josephine Hart's "Damage" (1991), Jane Smiley's "A Thousand Acres" (1991), and George Eliot's "Middlemarch" (1874). Nonfiction suggestions include Harlan Lane's…

A possible cause of the AO polarity reversal from winter to summer in 2010 and its relation to hemispheric extreme summer weather

NASA Astrophysics Data System (ADS)

Otomi, Yuriko; Tachibana, Yoshihiro; Nakamura, Tetsu

2013-04-01

In 2010, the Northern Hemisphere, in particular Russia and Japan, experienced an abnormally hot summer characterized by record-breaking warm temperatures and associated with a strongly positive Arctic Oscillation (AO), that is, low pressure in the Arctic and high pressure in the midlatitudes. In contrast, the AO index the previous winter and spring (2009/2010) was record-breaking negative. The AO polarity reversal that began in summer 2010 can explain the abnormally hot summer. The winter sea surface temperatures (SST) in the North Atlantic Ocean showed a tripolar anomaly pattern—warm SST anomalies over the tropics and high latitudes and cold SST anomalies over the midlatitudes—under the influence of the negative AO. The warm SST anomalies continued into summer 2010 because of the large oceanic heat capacity. A model simulation strongly suggested that the AO-related summertime North Atlantic oceanic warm temperature anomalies remotely caused blocking highs to form over Europe, which amplified the positive summertime AO. Thus, a possible cause of the AO polarity reversal might be the "memory" of the negative winter AO in the North Atlantic Ocean, suggesting an interseasonal linkage of the AO in which the oceanic memory of a wintertime negative AO induces a positive AO in the following summer. Understanding of this interseasonal linkage may aid in the long-term prediction of such abnormal summer events.

A possible cause of the AO polarity reversal from winter to summer in 2010 and its relation to hemispheric extreme hot summer

NASA Astrophysics Data System (ADS)

Tachibana, Yoshihiro; Otomi, Yuriko; Nakamura, Tetsu

2013-04-01

In 2010, the Northern Hemisphere, in particular Russia and Japan, experienced an abnormally hot summer characterized by record-breaking warm temperatures and associated with a strongly positive Arctic Oscillation (AO), that is, low pressure in the Arctic and high pressure in the midlatitudes. In contrast, the AO index the previous winter and spring (2009/2010) was record-breaking negative. The AO polarity reversal that began in summer 2010 can explain the abnormally hot summer. The winter sea surface temperatures (SST) in the North Atlantic Ocean showed a tripolar anomaly pattern—warm SST anomalies over the tropics and high latitudes and cold SST anomalies over the midlatitudes—under the influence of the negative AO. The warm SST anomalies continued into summer 2010 because of the large oceanic heat capacity. A model simulation strongly suggested that the AO-related summertime North Atlantic oceanic warm temperature anomalies remotely caused blocking highs to form over Europe, which amplified the positive summertime AO. Thus, a possible cause of the AO polarity reversal might be the "memory" of the negative winter AO in the North Atlantic Ocean, suggesting an interseasonal linkage of the AO in which the oceanic memory of a wintertime negative AO induces a positive AO in the following summer. Understanding of this interseasonal linkage may aid in the long-term prediction of such abnormal summer events.

Books for Summer Reading.

ERIC Educational Resources Information Center

Phi Delta Kappan, 1992

1992-01-01

Advises administrators to use their summers to relax and recharge their intellectual batteries. Reading suggestions include Edith Wharton's "House of Mirth," Charlotte Perkins Gilman's "The Yellow Wallpaper," Amy Tan's "Joy Luck Club," China Achebe's "Things Fall Apart," Paule Marshall's "The Chosen…

Hunger Doesn't Take a Vacation: Summer Nutrition Status Report.

ERIC Educational Resources Information Center

Food Research and Action Center, Washington, DC.

This report describes the current status of the Summer Food Service Program (SFSP) and the National School Lunch Program (NSLP) (referred to in combination as the Summer Nutrition Programs), federal entitlement programs providing support for state and local efforts to offer low-income children nutritious summer meals and snacks during supervised…

45 CFR 2400.48 - Fellows' participation in the Summer Institute.

Code of Federal Regulations, 2013 CFR

2013-10-01

... 45 Public Welfare 4 2013-10-01 2013-10-01 false Fellows' participation in the Summer Institute...' participation in the Summer Institute. Each fellow is required as part of his or her fellowship to attend the Institute (if it is offered), normally during the summer following the Fellow's commencement of graduate...

45 CFR 2400.48 - Fellows' participation in the Summer Institute.

Code of Federal Regulations, 2014 CFR

2014-10-01

... 45 Public Welfare 4 2014-10-01 2014-10-01 false Fellows' participation in the Summer Institute...' participation in the Summer Institute. Each fellow is required as part of his or her fellowship to attend the Institute (if it is offered), normally during the summer following the Fellow's commencement of graduate...

Summer Freeze: Engaging the Incoming Class to Reduce Admissions Melt

ERIC Educational Resources Information Center

Allen-Stuck, Kimberly M.; McDevitt, Daniel W.

2014-01-01

Persistence to graduation begins with engaging the incoming class even before they have made a deposit. Saint Joseph's University developed a framework for combatting the admissions summer melt following a summer where 20% of the deposits were withdrawn. By employing tactics to monitor student engagement throughout the summer and connecting with…

45 CFR 2400.48 - Fellows' participation in the Summer Institute.

Code of Federal Regulations, 2012 CFR

2012-10-01

... 45 Public Welfare 4 2012-10-01 2012-10-01 false Fellows' participation in the Summer Institute...' participation in the Summer Institute. Each fellow is required as part of his or her fellowship to attend the Institute (if it is offered), normally during the summer following the Fellow's commencement of graduate...

Fellowship Available: 2005 IIASA Young Scientists Summer Program

NASA Astrophysics Data System (ADS)

2004-12-01

The International Institute for Applied Systems Analysis (IIASA) near Vienna, Austria, will host its annual Young Scientists's Summer Program (YSSP) for a selected group of graduate students from around the world. These students, primarily doctoral, will work closely with IIASA's senior scientists on projects within the institute's theme areas: natural resources and environment (e.g., transboundary air pollution and greenhouse gas initiative), population and society (e.g., risk, modeling, and society, and sustainable rural development), and energy and technology (e.g., transitions to new technologies and dynamic systems). Applicants must be advanced graduate students at a U.S. university; have comparable experience with ongoing research at IIASA; students who would benefit from interactions with scientists worldwide; and be interested in investigating the policy implications of his/her work.The U.S. Committee for IIASA provides airfare and a living allowance for those selected to participate in the fellowship.

Approaches and Activities of Professional Development During Graduate/Postdoctoral Summer Workshops

NASA Astrophysics Data System (ADS)

Gross, N. A.; Wiltberger, M. J.; Hughes, W. J.; Bhattacharjee, A.; Schrijver, K.; Bagenal, F.; Sojka, J. J.; Munoz-Jaramillo, A.

2017-12-01

NSF and NASA each fund a space physics summer school - the Space Weather Summer School (https://www2.hao.ucar.edu/CISM-Summer-School) and the Heliophysics Summer School (https://cpaess.ucar.edu/heliophysics/summer-school) - each of which provide a comprehensive introduction to their fields at the conceptual and quantitative level for graduate and postdoctoral researchers. Along with specific content goals, each summer school also recognizes professional development goals for the students. Each school intentionally develops community among the summer school students to promote professional networking between the students and between students and instructors. Community is promoted both as part of the formal program and through informal gatherings and outings. Social media is intentionally used for this purpose as well. The summer schools also promote practice with discussing science concepts in small groups through peer instruction, practice presenting in small groups, and discussing results with minimal preparation. Short formal student presentations and poster sessions are organized as part of the formal schedule of one of the summer schools. Much of the professional development work is informed by improvisational theater approaches. Group improv training focuses on the development of the group or the community rather than the individual. Group improv activities are used to build the group and encourage full participation. This talk will outline the professional development activities in each school and how they are informed by improv.

Summer circulation in the Mexican tropical Pacific

NASA Astrophysics Data System (ADS)

Trasviña, A.; Barton, E. D.

2008-05-01

The main components of large-scale circulation of the eastern tropical Pacific were identified in the mid 20th century, but the details of the circulation at length scales of 10 2 km or less, the mesoscale field, are less well known particularly during summer. The winter circulation is characterized by large mesoscale eddies generated by intense cross-shore wind pulses. These eddies propagate offshore to provide an important source of mesoscale variability for the eastern tropical Pacific. The summer circulation has not commanded similar attention, the main reason being that the frequent generation of hurricanes in the area renders in situ observations difficult. Before the experiment presented here, the large-scale summer circulation of the Gulf of Tehuantepec was thought to be dominated by a poleward flow along the coast. A drifter-deployment experiment carried out in June 2000, supported by satellite altimetry and wind data, was designed to characterize this hypothesized Costa Rica Coastal Current. We present a detailed comparison between altimetry-estimated geostrophic and in situ currents estimated from drifters. Contrary to expectation, no evidence of a coherent poleward coastal flow across the gulf was found. During the 10-week period of observations, we documented a recurrent pattern of circulation within 500 km of shore, forced by a combination of local winds and the regional-scale flow. Instead of the Costa Rica Coastal Current, we found a summer eddy field capable of influencing large areas of the eastern tropical Pacific. Even in summer, the cross-isthmus wind jet is capable of inducing eddy formation.

Occurrence of human respiratory syncytial virus in summer in Japan.

PubMed

Shobugawa, Y; Takeuchi, T; Hibino, A; Hassan, M R; Yagami, R; Kondo, H; Odagiri, T; Saito, R

2017-01-01

In temperate zones, human respiratory syncytial virus (HRSV) outbreaks typically occur in cold weather, i.e. in late autumn and winter. However, recent outbreaks in Japan have tended to start during summer and autumn. This study examined associations of meteorological conditions with the numbers of HRSV cases reported in summer in Japan. Using data from the HRSV national surveillance system and national meteorological data for summer during the period 2007-2014, we utilized negative binomial logistic regression analysis to identify associations between meteorological conditions and reported cases of HRSV. HRSV cases increased when summer temperatures rose and when relative humidity increased. Consideration of the interaction term temperature × relative humidity enabled us to show synergistic effects of high temperature with HRSV occurrence. In particular, HRSV cases synergistically increased when relative humidity increased while the temperature was ⩾28·2 °C. Seasonal-trend decomposition analysis using the HRSV national surveillance data divided by 11 climate divisions showed that summer HRSV cases occurred in South Japan (Okinawa Island), Kyushu, and Nankai climate divisions, which are located in southwest Japan. Higher temperature and higher relative humidity were necessary conditions for HRSV occurrence in summer in Japan. Paediatricians in temperate zones should be mindful of possible HRSV cases in summer, when suitable conditions are present.

Summer Events at the Scientific Library | Poster

Cancer.gov

If it’s summer, then it’s time for Jeopardy and videos at the National Cancer Institute at Frederick! Traditionally, the Scientific Library has hosted a Science Jeopardy Tournament in July and offered a Summer Video Series in June, July, and August. This year will be no different, as the Scientific Library will host the 11th Annual Student Science Jeopardy Tournament and a

Summer Events at the Scientific Library | Poster

Cancer.gov

Two exciting events are coming this summer from the Scientific Library—the annual Student Science Jeopardy Tournament and the Summer Video Series. This year, the 10th Annual Student Science Jeopardy Tournament will be held on Wednesday, July 20, beginning at 10 a.m. in the auditorium of Building 549. The event will also be streamed live to the Advanced Technology Research Facility (ATRF), room E1203.

50 CFR 648.100 - Summer flounder Annual Catch Limit (ACL).

Code of Federal Regulations, 2014 CFR

2014-10-01

... 50 Wildlife and Fisheries 12 2014-10-01 2014-10-01 false Summer flounder Annual Catch Limit (ACL... Management Measures for the Summer Flounder Fisheries § 648.100 Summer flounder Annual Catch Limit (ACL). (a... frequent or more specific ACL performance review criteria as part of a stock rebuilding plan following a...

50 CFR 648.100 - Summer flounder Annual Catch Limit (ACL).

Code of Federal Regulations, 2013 CFR

2013-10-01

... 50 Wildlife and Fisheries 12 2013-10-01 2013-10-01 false Summer flounder Annual Catch Limit (ACL... Management Measures for the Summer Flounder Fisheries § 648.100 Summer flounder Annual Catch Limit (ACL). (a... frequent or more specific ACL performance review criteria as part of a stock rebuilding plan following a...

50 CFR 648.100 - Summer flounder Annual Catch Limit (ACL).

Code of Federal Regulations, 2012 CFR

2012-10-01

... 50 Wildlife and Fisheries 12 2012-10-01 2012-10-01 false Summer flounder Annual Catch Limit (ACL... Management Measures for the Summer Flounder Fisheries § 648.100 Summer flounder Annual Catch Limit (ACL). (a... frequent or more specific ACL performance review criteria as part of a stock rebuilding plan following a...

My Summer Vacation

ERIC Educational Resources Information Center

Galus, Pamela

2010-01-01

In this article, a science teacher from the Midwest reflects on her summer vacation to the Gulf of Mexico. She felt that this vacation would help improve her teaching about the environmental problems in the gulf and elsewhere. After all, anyone can show photos of oil-laden birds and dead sea turtles and read news clips of a distant place, but to…

Bioengineering and Bioinformatics Summer Institutes: Meeting Modern Challenges in Undergraduate Summer Research

ERIC Educational Resources Information Center

Butler, Peter J.; Dong, Cheng; Snyder, Alan J.; Jones, A. Daniel; Sheets, Erin D.

2008-01-01

Summer undergraduate research programs in science and engineering facilitate research progress for faculty and provide a close-ended research experience for students, which can prepare them for careers in industry, medicine, and academia. However, ensuring these outcomes is a challenge when the students arrive ill-prepared for substantive research…

Project SMART (Summer Migrants Access Resources through Technology).

ERIC Educational Resources Information Center

Texas Education Agency, Austin. Div. of Migrant Education.

The SMART (Summer Migrants Access Resources through Technology) project provides Texas migrant students with supplemental instruction using a multi-media, nontraditional approach. Migrant students who remain in Texas during the summer are taught in their homes or other sites via televised instruction with additional instructional support from…

Assessing national forest visitors' comprehension of international symbols for communicating outdoor recreation messages

Treesearch

Deborah J. Chavez; Nancy E. Knap; Deanne G. McCollum

2004-01-01

The purpose of this researchwas to evaluate recreationists' comprehension of International Symbols used on the Angeles and San Bernardino National Forests in southern California. Data were collected from 262 recreationists during the summer months 2002. Bilingual teams administered the survey using instruments available in English and Spanish. The 20 International...

Warm summers during the Younger Dryas cold reversal.

PubMed

Schenk, Frederik; Väliranta, Minna; Muschitiello, Francesco; Tarasov, Lev; Heikkilä, Maija; Björck, Svante; Brandefelt, Jenny; Johansson, Arne V; Näslund, Jens-Ove; Wohlfarth, Barbara

2018-04-24

The Younger Dryas (YD) cold reversal interrupts the warming climate of the deglaciation with global climatic impacts. The sudden cooling is typically linked to an abrupt slowdown of the Atlantic Meridional Overturning Circulation (AMOC) in response to meltwater discharges from ice sheets. However, inconsistencies regarding the YD-response of European summer temperatures have cast doubt whether the concept provides a sufficient explanation. Here we present results from a high-resolution global climate simulation together with a new July temperature compilation based on plant indicator species and show that European summers remain warm during the YD. Our climate simulation provides robust physical evidence that atmospheric blocking of cold westerly winds over Fennoscandia is a key mechanism counteracting the cooling impact of an AMOC-slowdown during summer. Despite the persistence of short warm summers, the YD is dominated by a shift to a continental climate with extreme winter to spring cooling and short growing seasons.

The role of summer surface wind anomalies in the summer Arctic sea ice extent in 2010 and 2011

NASA Astrophysics Data System (ADS)

Ogi, M.; Wallace, J. M.

2012-12-01

Masayo Ogi 1 and John M. Wallace 2 masayo.ogi@jamstec.go.jp wallace@atmos.washington.edu 1Japan Agency for Marine-Earth Science and Technology, Yokohama, Japan 2 Department of Atmospheric Sciences, University of Washington, Seattle, Washington The seasonal evolutions of Arctic sea ice extent (SIE) during the summers of 2010 and 2011 are contrasted with that in 2007. The June SIE in 2010 was lower than that in 2007 and was the lowest for that calendar month in the 32-year (1979-2010) record. The September SIE in 2010 would have set a new record low had it not been for the fact that the ice retreated more slowly during the summer months in that year than it did in 2007. Hence from early July onward, the SIE in 2010 remained at levels above those observed in 2007. The SIE minimum in September 2010 proved to be the third lowest on record, eclipsed by values in both 2007 and 2008. In spring and summer of 2011, the Arctic SIE was as low as it was in 2007, but the SIE in September 2011 did not reach record low levels. The SIE minimum in 2011 proved to be the second lowest on record for the period of 1979-2011. Summertime atmospheric conditions play an important role in controlling the variations in Arctic SIE. In a previous study based on statistical analysis of data collected prior to 2007, we showed that anticyclonic summertime circulation anomalies over the Arctic Ocean during the summer months favor low September SIE. We also found that the record-low ice summer year 2007 was characterized by a strong anticyclonic circulation anomaly, accompanied by an Ekman drift of ice out of the marginal seas toward the central Arctic and eventually toward the Fram Strait, as evidenced by the tracks of drifting buoys. Here we assess the extent to which year-to-year differences in summer winds over the Arctic might have contributed to the differing rates of retreat of ice during the summers of 2007, 2010, and 2011. Our results show that the May-June (MJ) pattern in 2010 is

Counteracting Summer Slide: Social Capital Resources within Socioeconomically Disadvantaged Families

ERIC Educational Resources Information Center

Slates, Stephanie L.; Alexander, Karl L.; Entwisle, Doris R.; Olson, Linda S.

2012-01-01

Research on summer learning has shown that children from a higher socioeconomic status (SES) continue to learn during the summer months of elementary school, but lower-SES students tend to stagnate or lose ground. However, not all low-SES students experience summer learning loss. Drawing on the Beginning School Study (BSS), a longitudinal study of…

New Directions in Communication: Proceedings of the 1972 International Communications Association Student Summer Conference (Flint, Mich., August 16-18, 1972).

ERIC Educational Resources Information Center

Tubbs, Stewart L., Ed.

Twelve papers were presented at the first student summer conference of the ICA. The introductory paper reviews contemporary approaches to teaching communication theory and research and its application. The papers in Part I, "New Directions in Theory and Research," focus on the following topics: (1) redirection of the focus of…

Summer South Polar Cap

NASA Technical Reports Server (NTRS)

2004-01-01

13 April 2004 The martian south polar residual ice cap is composed mainly of frozen carbon dioxide. Each summer, a little bit of this carbon dioxide sublimes away. Pits grow larger, and mesas get smaller, as this process continues from year to year. This Mars Global Surveyor (MGS) Mars Orbiter Camera (MOC) image shows a view of a small portion of the south polar cap as it appeared in mid-summer in January 2004. The dark areas may be places where the frozen carbon dioxide contains impurities, such as dust, or places where sublimation of ice has roughened the surface so that it appears darker because of small shadows cast by irregularities in the roughened surface. The image is located near 86.9oS, 7.6oW. The image covers an area about 3 km (1.9 mi) across. Sunlight illuminates the scene from the upper left.

Hydromania: Summer Science Camp Curriculum.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Moura, Joan

1995-07-01

In 1992, Bonneville Power Administration (BPA) and the US Department of Energy (DOE) began a collaborative pilot project with the Portland Parks and Recreation Community Schools Program and others to provide summer science camps to children in Grades 4--6. Camps run two weeks in duration between late June and mid-August. Sessions are five days per week, from 9 a.m. to 3 p.m. In addition to hands-on science and math curriculum, at least three field trips are incorporated into the educational learning experience. The purpose of the BPA/DOE summer camps is to make available opportunities for fun, motivating experiences in sciencemore » to students who otherwise would have difficulty accessing them. This includes inner city, minority, rural and low income students. Public law 101-510, which Congress passed in 1990, authorizes DOE facilities to establish collaborative inner-city and rural partnership programs in science and math. A primary goal of the BPA summer hands on science camps is to bring affordable science camp experiences to students where they live. It uses everyday materials to engage students` minds and to give them a sense that they have succeeded through a fun hands-on learning environment.« less

Factors controlling the interannual variation of 30-60-day boreal summer intraseasonal oscillation over the Asian summer monsoon region

NASA Astrophysics Data System (ADS)

Li, Jianying; Mao, Jiangyu

2018-04-01

The 30-60-day boreal summer intraseasonal oscillation (BSISO) is a dominant variability of the Asian summer monsoon (ASM), with its intensity being quantified by intraseasonal standard deviations based on OLR data. The spatial and interannual variations of the BSISO intensity are identified via empirical orthogonal function (EOF) analysis for the period 1981-2014. The first EOF mode (EOF1) shows a spatially coherent enhancement or suppression of BSISO activity over the entire ASM region, and the interannual variability of this mode is related to the sea surface temperature anomaly (SSTA) contrast between the central-eastern North Pacific (CNP) and tropical Indian Ocean. In contrast, the second mode (EOF2) exhibits a seesaw pattern between the southeastern equatorial Indian Ocean (EIO) and equatorial western Pacific (EWP), with the interannual fluctuation linked with developing ENSO events. During strong years of EOF1 mode, the enhanced low-level westerlies induced by the summer-mean SSTA contrast between the warmer CNP and cooler tropical Indian Ocean tend to form a wetter moisture background over the eastern EIO, which interacts with intraseasonal low-level convergent flows, leading to stronger equatorial eastward propagation. The intensified easterly shear favors stronger northward propagation over the South Asian and Eastern Asian/Western North Pacific sectors, respectively. Opposite situation is for weak years. For interannual variations of EOF2 mode, the seesaw patterns with enhanced BSISO activity over the southeastern EIO while weakened activity over the EWP mostly occur in the La Niña developing summers, but inverse patterns appear in the El Niño developing summers.

Summer Bridge Programs. What Works Clearinghouse Intervention Report

ERIC Educational Resources Information Center

What Works Clearinghouse, 2016

2016-01-01

"Summer bridge programs" are designed to ease the transition to college and support postsecondary success by providing students with the academic skills and social resources needed to succeed in a college environment. These programs occur in the summer "bridge" period between high school and college. Although the content of…

Metabolic coupling and the Reverse Warburg Effect in cancer: Implications for novel biomarker and anticancer agent development.

PubMed

Wilde, Lindsay; Roche, Megan; Domingo-Vidal, Marina; Tanson, Katherina; Philp, Nancy; Curry, Joseph; Martinez-Outschoorn, Ubaldo

2017-06-01

Glucose is a key metabolite used by cancer cells to generate ATP, maintain redox state and create biomass. Glucose can be catabolized to lactate in the cytoplasm, which is termed glycolysis, or alternatively can be catabolized to carbon dioxide and water in the mitochondria via oxidative phosphorylation. Metabolic heterogeneity exists in a subset of human tumors, with some cells maintaining a glycolytic phenotype while others predominantly utilize oxidative phosphorylation. Cells within tumors interact metabolically with transfer of catabolites from supporting stromal cells to adjacent cancer cells. The Reverse Warburg Effect describes when glycolysis in the cancer-associated stroma metabolically supports adjacent cancer cells. This catabolite transfer, which induces stromal-cancer metabolic coupling, allows cancer cells to generate ATP, increase proliferation, and reduce cell death. Catabolites implicated in metabolic coupling include the monocarboxylates lactate, pyruvate, and ketone bodies. Monocarboxylate transporters (MCT) are critically necessary for release and uptake of these catabolites. MCT4 is involved in the release of monocarboxylates from cells, is regulated by catabolic transcription factors such as hypoxia inducible factor 1 alpha (HIF1A) and nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB), and is highly expressed in cancer-associated fibroblasts. Conversely, MCT1 is predominantly involved in the uptake of these catabolites and is highly expressed in a subgroup of cancer cells. MYC and TIGAR, which are genes involved in cellular proliferation and anabolism, are inducers of MCT1. Profiling human tumors on the basis of an altered redox balance and intra-tumoral metabolic interactions may have important biomarker and therapeutic implications. Alterations in the redox state and mitochondrial function of cells can induce metabolic coupling. Hence, there is interest in redox and metabolic modulators as anticancer agents. Also

Outer Space...Calling All Readers. 1991 Summer Reading Program Manual.

ERIC Educational Resources Information Center

North Carolina State Dept. of Cultural Resources, Raleigh. Div. of State Library.

This manual provides guidelines and materials for librarians planning a summer reading program for children in North Carolina on the theme of outer space. An evaluation form to be returned to the State Library of North Carolina at the end of the summer is included. The introduction includes discussions of summer reading materials and programs;…

Specialized Summer Camps: Provide Benefits for Children and Families Alike

ERIC Educational Resources Information Center

Neff, John M.

2009-01-01

The arrival of summer signals a season of endless days of swimming, fishing, summer camps, and other outdoor activities. For children with chronic or terminal illnesses, it can be difficult to participate in many of these activities as well as challenging for parents to find summer camps that not only engage their children, but also offer the…

Connecting for High Potential... "Here Comes Summer." CHP Issue 27

ERIC Educational Resources Information Center

Danielian, Jeff; Nilles, Kathleen

2015-01-01

Summer vacation is right around the corner! However, just as quickly as summer approaches, it also passes in the blink of an eye. This time of year, both parents and teachers face the same dilemma: Should high-ability kids stay busy with summer projects, courses, sports, camps, and travel...or should they be allowed to completely unplug with no…

Conducting Summer School in Agriculture

ERIC Educational Resources Information Center

Lloyd, Melvin

1976-01-01

Course objectives, student competencies, and class session schedules are outlined for two high school vocational agriculture summer courses: Livestock and Livestock Products Evaluation and Agribusiness Leadership Seminar. (MS)

Summer Events at the Scientific Library | Poster

Cancer.gov

If it’s summer, then it’s time for Jeopardy and videos at the National Cancer Institute at Frederick! Traditionally, the Scientific Library has hosted a Science Jeopardy Tournament in July and offered a Summer Video Series in June, July, and August. This year will be no different, as the Scientific Library will host the 11th Annual Student Science Jeopardy Tournament and a six-week series of film screenings.

Impact of Summer Recess on Mathematics Learning Retention

ERIC Educational Resources Information Center

Hornack, David

2016-01-01

School administrators across the nation are actively searching for solutions to increase student achievement due in part to the significant amount of knowledge that is lost annually each summer. Mathematical computation skills are especially at-risk. This quantitative research study was designed to investigate the impact of summer recess also…

Upcoming Summer Programs for Students and Staff | Poster

Cancer.gov

By Robin Meckley, Contributing Writer This summer, the Scientific Library is hosting three programs for students and NCI at Frederick staff: the Summer Video Series, Mini Science Film & Discussion Series, and Eighth Annual Student Science Jeopardy Tournament. Complete information on the programs is available on the Scientific Library’s website.

Have a Bearable Summer-Read: An Activity Guide.

ERIC Educational Resources Information Center

Jackson, Mary, Ed.

Designed to help librarians plan a summer reading program around the theme of bears called "have a bearable summer," this activity guide presents many activities and organizational suggestions. The first section of the guide deals with publicity and public relations, while the second section covers story time activities. The third…

Summer Research Apprentice Program report. [Summer Research Apprentice Program

DOE Office of Scientific and Technical Information (OSTI.GOV)

Curington, B.

1982-01-01

The Summer Research Apprentice Program is designed to provide students with their first look at college life while preparing them for possible careers in mathematics, science and engineering. The 23 students, enrolled as college freshmen for 8 hours of college credit, took courses in Trigonometry, College Algebra and introduction to Research (4 students were enrolled in Calculus 1 instead of Trigonometry and College Albebra). During this third year of operation, refinements were made in both the administration of the program and in the method of implementation.

Warm Mediterranean mid-Holocene summers inferred from fossil midge assemblages

NASA Astrophysics Data System (ADS)

Samartin, Stéphanie; Heiri, Oliver; Joos, Fortunat; Renssen, Hans; Franke, Jörg; Brönnimann, Stefan; Tinner, Willy

2017-02-01

Understanding past climate trends is key for reliable projections of global warming and associated risks and hazards. Uncomfortably large discrepancies between vegetation-based summer temperature reconstructions (mainly based on pollen) and climate model results have been reported for the current interglacial, the Holocene. For the Mediterranean region these reconstructions indicate cooler-than-present mid-Holocene summers, in contrast with expectations based on climate models and long-term changes in summer insolation. We present new quantitative and replicated Holocene summer temperature reconstructions based on fossil chironomid midges from the northern central Mediterranean region. The Holocene thermal maximum is reconstructed 9,000-5,000 years ago and estimated to have been 1-2 °C warmer in mean July temperature than the recent pre-industrial period, consistent with glacier and marine records, and with transient climate model runs. This combined evidence implies that widely used pollen-based summer temperature reconstructions in the Mediterranean area are significantly biased by precipitation or other forcings such as early land use. Our interpretation can resolve the previous discrepancy between climate models and quantitative palaeotemperature records for millennial-scale Holocene summer temperature trends in the Mediterranean region. It also suggests that pollen-based evidence for cool mid-Holocene summers in other semi-arid to arid regions of the Northern Hemisphere may have to be reconsidered, with potential implications for global-scale reconstructions.

Summer Bookaneers: Sign on with Captain Book. 1990 Florida Summer Library Program.

ERIC Educational Resources Information Center

Fiore, Carole D., Comp.; Fine, Jana R., Comp.

Designed for use by children's librarians in organizing and conducting a summer reading program for children 5 through 12 years of age, this "log book" contains suggestions for activities related to a seafaring theme together with lists of selected materials relevant to the particular activities. Samples of a press release and several…

2008 Montana Summer Transportation Institute.

DOT National Transportation Integrated Search

2008-09-01

The Western Transportation Institute hosted a two-week residential Summer Transportation Institute for eleven high school students on the Montana State University campus from June 15 to June 27, 2008.

Summer School in Deep Ecology.

ERIC Educational Resources Information Center

Macmillan, Catherine Hume

1995-01-01

Describes one teacher's experiences at the Institute for Deep Ecology Education (IDEE) Summer School in Applied Deep Ecology. Reviews the program offered and the focus on interactive, experiential activities. (LZ)

Summer Research Experiences with a Laboratory Tokamak

NASA Astrophysics Data System (ADS)

Farley, N.; Mauel, M.; Navratil, G.; Cates, C.; Maurer, D.; Mukherjee, S.; Shilov, M.; Taylor, E.

1998-11-01

Columbia University's Summer Research Program for Secondary School Science Teachers seeks to improve middle and high school student understanding of science. The Program enhances science teachers' understanding of the practice of science by having them participate for two consecutive summers as members of laboratory research teams led by Columbia University faculty. In this poster, we report the research and educational activities of two summer internships with the HBT-EP research tokamak. Research activities have included (1) computer data acquisition and the representation of complex plasma wave phenomena as audible sounds, and (2) the design and construction of pulsed microwave systems to experience the design and testing of special-purpose equipment in order to achieve a specific technical goal. We also present an overview of the positive impact this type of plasma research involvement has had on high school science teaching.

Cystic kidneys in fetal Walker-Warburg syndrome with POMT2 mutation: Intrafamilial phenotypic variability in four siblings and review of literature.

PubMed

Nabhan, Marwa M; ElKhateeb, Nour; Braun, Daniela A; Eun, Sungho; Saleem, Sahar N; YungGee, Heon; Hildebrandt, Friedhelm; Soliman, Neveen A

2017-10-01

Walker-Warburg syndrome (WWS) is a severe form of congenital muscular dystrophy secondary to α-dystroglycanopathy with muscle, brain, and eye abnormalities often leading to death in the first weeks of life. It is transmitted in an autosomal recessive pattern, and has been linked to at least 15 different genes; including protein O-mannosyltransferase 1 (POMT1), protein O-mannosyltransferase 2 (POMT2), protein O-mannose beta-1,2-N acetylglucosaminyltransferase (POMGNT1), fukutin (FKTN), isoprenoid synthase domain-containing protein (ISPD), and other genes. We report on a consanguineous family with four consecutive siblings affected by this condition with lethal outcome in three (still birth), and termination of the fourth pregnancy based on antenatal MRI identification of brain and kidney anomalies that heralded proper and deep clinical phenotyping. The diagnosis of WWS was suggested based on the unique collective phenotype comprising brain anomalies in the form of lissencephaly, subcortical/subependymal heterotopia, and cerebellar hypoplasia shared by all four siblings; microphthalmia in one sibling; and large cystic kidneys in the fetus and another sibling. Other unshared neurological abnormalities included hydrocephalus and Dandy-Walker malformation. Whole exome sequencing of the fetus revealed a highly conserved missense mutation in POMT2 that is known to cause WWS with brain and eye anomalies.In conclusion, the heterogeneous clinical presentation in the four affected conceptions with POMT2 mutation expands the current clinical spectrum of POMT2-associated WWS to include large cystic kidneys; and confirms intra-familial variability in terms of brain, kidney, and eye anomalies. © 2017 Wiley Periodicals, Inc.

Response of Submerged Macrophyte Communities to External and Internal Restoration Measures in North Temperate Shallow Lakes.

PubMed

Hilt, Sabine; Alirangues Nuñez, Marta M; Bakker, Elisabeth S; Blindow, Irmgard; Davidson, Thomas A; Gillefalk, Mikael; Hansson, Lars-Anders; Janse, Jan H; Janssen, Annette B G; Jeppesen, Erik; Kabus, Timm; Kelly, Andrea; Köhler, Jan; Lauridsen, Torben L; Mooij, Wolf M; Noordhuis, Ruurd; Phillips, Geoff; Rücker, Jacqueline; Schuster, Hans-Heinrich; Søndergaard, Martin; Teurlincx, Sven; van de Weyer, Klaus; van Donk, Ellen; Waterstraat, Arno; Willby, Nigel; Sayer, Carl D

2018-01-01

Submerged macrophytes play a key role in north temperate shallow lakes by stabilizing clear-water conditions. Eutrophication has resulted in macrophyte loss and shifts to turbid conditions in many lakes. Considerable efforts have been devoted to shallow lake restoration in many countries, but long-term success depends on a stable recovery of submerged macrophytes. However, recovery patterns vary widely and remain to be fully understood. We hypothesize that reduced external nutrient loading leads to an intermediate recovery state with clear spring and turbid summer conditions similar to the pattern described for eutrophication. In contrast, lake internal restoration measures can result in transient clear-water conditions both in spring and summer and reversals to turbid conditions. Furthermore, we hypothesize that these contrasting restoration measures result in different macrophyte species composition, with added implications for seasonal dynamics due to differences in plant traits. To test these hypotheses, we analyzed data on water quality and submerged macrophytes from 49 north temperate shallow lakes that were in a turbid state and subjected to restoration measures. To study the dynamics of macrophytes during nutrient load reduction, we adapted the ecosystem model PCLake. Our survey and model simulations revealed the existence of an intermediate recovery state upon reduced external nutrient loading, characterized by spring clear-water phases and turbid summers, whereas internal lake restoration measures often resulted in clear-water conditions in spring and summer with returns to turbid conditions after some years. External and internal lake restoration measures resulted in different macrophyte communities. The intermediate recovery state following reduced nutrient loading is characterized by a few macrophyte species (mainly pondweeds) that can resist wave action allowing survival in shallow areas, germinate early in spring, have energy-rich vegetative

Response of Submerged Macrophyte Communities to External and Internal Restoration Measures in North Temperate Shallow Lakes

PubMed Central

Hilt, Sabine; Alirangues Nuñez, Marta M.; Bakker, Elisabeth S.; Blindow, Irmgard; Davidson, Thomas A.; Gillefalk, Mikael; Hansson, Lars-Anders; Janse, Jan H.; Janssen, Annette B. G.; Jeppesen, Erik; Kabus, Timm; Kelly, Andrea; Köhler, Jan; Lauridsen, Torben L.; Mooij, Wolf M.; Noordhuis, Ruurd; Phillips, Geoff; Rücker, Jacqueline; Schuster, Hans-Heinrich; Søndergaard, Martin; Teurlincx, Sven; van de Weyer, Klaus; van Donk, Ellen; Waterstraat, Arno; Willby, Nigel; Sayer, Carl D.

2018-01-01

Submerged macrophytes play a key role in north temperate shallow lakes by stabilizing clear-water conditions. Eutrophication has resulted in macrophyte loss and shifts to turbid conditions in many lakes. Considerable efforts have been devoted to shallow lake restoration in many countries, but long-term success depends on a stable recovery of submerged macrophytes. However, recovery patterns vary widely and remain to be fully understood. We hypothesize that reduced external nutrient loading leads to an intermediate recovery state with clear spring and turbid summer conditions similar to the pattern described for eutrophication. In contrast, lake internal restoration measures can result in transient clear-water conditions both in spring and summer and reversals to turbid conditions. Furthermore, we hypothesize that these contrasting restoration measures result in different macrophyte species composition, with added implications for seasonal dynamics due to differences in plant traits. To test these hypotheses, we analyzed data on water quality and submerged macrophytes from 49 north temperate shallow lakes that were in a turbid state and subjected to restoration measures. To study the dynamics of macrophytes during nutrient load reduction, we adapted the ecosystem model PCLake. Our survey and model simulations revealed the existence of an intermediate recovery state upon reduced external nutrient loading, characterized by spring clear-water phases and turbid summers, whereas internal lake restoration measures often resulted in clear-water conditions in spring and summer with returns to turbid conditions after some years. External and internal lake restoration measures resulted in different macrophyte communities. The intermediate recovery state following reduced nutrient loading is characterized by a few macrophyte species (mainly pondweeds) that can resist wave action allowing survival in shallow areas, germinate early in spring, have energy-rich vegetative

A Flying Summer Camp

ERIC Educational Resources Information Center

Mercurio, Frank X.

1975-01-01

Describes a five-day summer camp which provided 12 children, ages 9-14, with a complete flying experience. The training consisted of ground school and one hour actual flying time, including the basics of aircraft control and a flight prepared and executed by the students. (MLH)

Summer Opportunities for Students.

ERIC Educational Resources Information Center

Winds of Change, 2003

2003-01-01

Eleven summer internships, work experience programs, research opportunities, and courses are described. Some offer stipends. Some are specifically for American Indian, minority, disadvantaged, or disabled students in high school or college. Most are in science or engineering related fields. Each entry contains a brief program description,…

Books for Summer Reading.

ERIC Educational Resources Information Center

Phi Delta Kappan, 1996

1996-01-01

Suggests several novels for educators' summer reading enjoyment, including classics by Robert Pirsig, Robertson Davies, John Steinbeck, Albert Camus, and Charles Dickens. Educators might also read Alex Kotlowitz's "There Are No Children Here" (Doubleday, 1991) and Sharon Quint's "Schooling Homeless Children" (Teachers College Press, 1994) to gain…

Summer graduate research program for interns in science and engineering

NASA Technical Reports Server (NTRS)

Lee, Clinton B.

1992-01-01

The goal of the 10 week graduate intern program was to increase the source of candidates for positions in science and engineering at the Goddard Space Flight Center. Students participating in this program submitted papers on the work they performed over the 10 week period and also filled out questionnaires on the program's effectiveness, their own performance, and suggestions on improvements. The topics covered by the student's papers include: microsoft excel applications; fast aurora zone analysis; injection seeding of a Q-switched alexandrite laser; use of high temperature superconductors; modifications on a communication interface board; modeling of space network activities; prediction of atmospheric ozone content; and applications of industrial engineering.

Poland and Czecho-Slovakia in the 1990's: Social, Political and Economic Transformations. Fulbright-Hays Summer Seminars Abroad Program. Summer 1992.

ERIC Educational Resources Information Center

Institute of International Education, New York, NY.

This document features writings and curriculum projects developed by teachers who traveled to Poland and Czechoslovakia in the summer of 1992 as members of a Fulbright-Hays Summer Seminar. The following items are among those included: "Curriculum Project: Women and Work: A Global Perspective" (Joan K. Burton); "The Community College…

Early-Holocene decoupled summer temperature and monsoon precipitation in southwest China

NASA Astrophysics Data System (ADS)

Wu, D.; Chen, F.; Chen, X.; Lv, F.; Zhou, A.; Chen, J.; Abbott, M. B.; Yu, J.

2017-12-01

Proxy based reconstructions of Holocene temperature have shown that both the timing and magnitude of the thermal maximum vary substantially between different regions; the simulations results from climate models also show that summers were substantially cooler over regions directly influenced by the presence of the Laurentide ice sheet during the early Holocene, whereas other regions of the Northern Hemisphere were dominated by orbital forcing. However, for lack of summer temperature reconstruction in the low latitude regions like southwestern China dominated by the Indian summer monsoon, the Holocene summer temperature variations and it underlying forcing mechanism are ambiguous. Here we present a well-dated record of pollen-based quantitative summer temperature (mean July; MJT) over the last 14000 years from Xingyun Lake, Yunnan Province, southwest China. It was found that MJT decreased during the YD event, then increased slowly until 7400 yr BP, and decreased thereafter. The MJT shows a pattern with middle Holocene maximum of MJT, indicating a different changing pattern with the carbonate oxygen isotope record (d18O) from the same core during the early Holocene (11500-7400 yr BP), which has the similar variation with speleothem d18O record from Dongge cave, both indicate the variation of monsoon precipitation with the highest precipitation occurred during the early Holocene. Therefore, we propose that the variation of summer temperature and precipitation in southwest China was decoupled during the early Holocene. However, both MJT and monsoon precipitation decreased after the middle Holocene following the boreal summer insolation. We suggest that the high precipitation with strong summer monsoon and hence higher cloud cover may depress the temperature increasing forced by increasing summer insolation during the early Holocene; while melting ice-sheet in the high latitude regions had strongly influenced the summer temperature increase during the deglacial period

CCR Interns | Center for Cancer Research

Cancer.gov

The Cancer Research Interns (CRI) Summer Program was inaugurated in 2004 to provide an open door for students looking for an initial training opportunity. The goal is to enhance diversity within the CCR (Center for Cancer Research) training program and we have placed 338 students from 2004 to 2017, in labs and branches across the division.  The CCR and the Center for Cancer

MIGRATION PATTERNS, USE OF STOPOVER AREAS, AND AUSTRAL SUMMER MOVEMENTS OF SWAINSON'S HAWKS.

PubMed

Kochert, Michael N; Fuller, Mark R; Schueck, Linda S; Bond, Laura; Bechard, Marc J; Woodbridge, Brian; Holroyd, Geoff; Martell, Mark; Banasch, Ursula

From 1995-1998, we tracked movements of adult Swainson's Hawks ( Buteo swainsoni ) using satellite telemetry to characterize migration, important stopover areas, and austral summer movements. We tagged 46 hawks from July - September on their nesting grounds in seven U.S. states and two Canadian provinces. Swainson's Hawks basically followed three routes south on a broad front, converged along the east coast of central Mexico, and followed a concentrated corridor to a communal austral summer area in central Argentina. North of 20° N, southward and northward tracks differed little for individuals from east of the Continental Divide but differed greatly (up to 1700 km) for individuals from west of the Continental Divide. Hawks left the breeding grounds mid-August to mid-October; departure dates did not differ by location, year, or sex. South migration lasted 42 to 98 days, and north migration took 51 to 82 days. On south migration, 36% of the Swainson's Hawks departed the nesting grounds nearly 3 weeks earlier than the other radio marked hawks and made stopovers 9.0 - 26.0 days long in seven separate areas, mainly in the southern Great Plains, southern Arizona and New Mexico, and north-central Mexico. The austral period lasted 76 to 128 days. All Swainson's Hawks used a core area in central Argentina within 23% of the 738800 km 2 austral summer range where they frequently moved long distances (up to 1600 km). Conservation of Swainson's Hawks must be an international effort that considers habitats used during nesting and non-nesting seasons including migration stopovers.

Avalanche Accidents Causing Fatalities: Are They Any Different in the Summer?

PubMed

Pasquier, Mathieu; Hugli, Olivier; Kottmann, Alexandre; Techel, Frank

2017-03-01

Pasquier, Mathieu, Olivier Hugli, Alexandre Kottmann, and Frank Techel. Avalanche accidents causing fatalities: are they any different in the summer? High Alt Med Biol. 18:67-72, 2017. This retrospective study investigated the epidemiology of summer avalanche accidents that occurred in Switzerland and caused at least one fatality between 1984 and 2014. Summer avalanche accidents were defined as those that occurred between June 1st and October 31st. Summer avalanches caused 21 (4%) of the 482 avalanches with at least one fatality occurring during the study period, and 40 (6%) of the 655 fatalities. The number of completely buried victims per avalanche and the proportion of complete burials among trapped people were lower in summer than in winter. Nevertheless, the mean number of fatalities per avalanche was higher in summer than in winter: 1.9 ± 1.2 (standard deviation; range 1-6) versus 1.3 ± 0.9 (range 1-7; p < 0.001). Trauma was the presumed cause of death in 94% (33 of 35) in summer avalanche accidents. Sixty-five percent of fully buried were found due to visual clues at the snow surface. Fatal summer avalanche accidents caused a higher mean number of fatalities per avalanche than winter avalanches, and those deaths resulted mostly from trauma. Rescue teams should anticipate managing polytrauma for victims in summer avalanche accidents rather than hypothermia or asphyxia; they should be trained in prehospital trauma life support and equipped accordingly to ensure efficient patient care.

Change in Behaviors of First Year Intern Teachers.

ERIC Educational Resources Information Center

Hill, Russell A.; Medley, Donald M.

A study measured changes in the teaching behavior of 70 first-year Temple University interns teaching in metropolitan Philadelphia secondary schools. Subjects, selected from 110 on the basis of subject and grade level, had received 6 weeks of graduate training in the summer prior to placement; they participated throughout the year in seminar…

Leveraging up Summers on Campus; Avoiding Lost Opportunities

ERIC Educational Resources Information Center

Gross, Karen

2014-01-01

New England's long winter and seemingly interminable wait for spring has this author thinking about what colleges could do with their campuses during the summer. The options are almost infinite, although the cost-benefit analysis clearly varies. For some students, being on campus in the summer is preferable to going home, where the environments…

Summer Spectacular: Children's Literature Workshops, Institutes, and Classes

ERIC Educational Resources Information Center

Huff, Karen; Pavonetti, Linda; Roser, Nancy

2012-01-01

No matter how long teachers have been out of school, or how many children's literature classes they have taught, when summer comes, most of them long to "go back to class." It is because of the intriguing, exciting, reinvigorating institutes and conferences their colleagues offer in summer. In this interview, two veteran planners of summer…

The Misattribution of Summers in Teacher Value-Added

ERIC Educational Resources Information Center

Atteberry, Allison

2012-01-01

This paper investigates the extent to which spring-to-spring testing timelines bias teacher value-added as a result of conflating summer and school-year learning. Using a unique dataset that contains both fall and spring standardized test scores, the author examines the patterns in school-year versus summer learning. She estimates value-added…

50 CFR 648.110 - Summer flounder framework adjustments to management measures.

Code of Federal Regulations, 2011 CFR

2011-10-01

... UNITED STATES Management Measures for the Summer Flounder Fisheries § 648.110 Summer flounder framework... instead of a framework adjustment. (2) MAFMC recommendation. After developing management actions and... 50 Wildlife and Fisheries 10 2011-10-01 2011-10-01 false Summer flounder framework adjustments to...

Thriller-Dillers & Chillers. Wisconsin Summer Library Program Manual, 1985. Bulletin No. 5212.

ERIC Educational Resources Information Center

Johnson, Debra Wilcox, Ed.

The Wisconsin Summer Library Program was developed to promote use of the library by children during the summer, to familiarize them with the resources of the public library, and to help them retain their reading skills over the summer. Different ways of interpreting the theme of the summer program for 1985 were suggested by librarians throughout…

50 CFR 648.110 - Summer flounder framework adjustments to management measures.

Code of Federal Regulations, 2012 CFR

2012-10-01

... UNITED STATES Management Measures for the Summer Flounder Fisheries § 648.110 Summer flounder framework... 50 Wildlife and Fisheries 12 2012-10-01 2012-10-01 false Summer flounder framework adjustments to management measures. 648.110 Section 648.110 Wildlife and Fisheries FISHERY CONSERVATION AND MANAGEMENT...

50 CFR 648.110 - Summer flounder framework adjustments to management measures.

Code of Federal Regulations, 2013 CFR

2013-10-01

... UNITED STATES Management Measures for the Summer Flounder Fisheries § 648.110 Summer flounder framework... 50 Wildlife and Fisheries 12 2013-10-01 2013-10-01 false Summer flounder framework adjustments to management measures. 648.110 Section 648.110 Wildlife and Fisheries FISHERY CONSERVATION AND MANAGEMENT...

50 CFR 648.110 - Summer flounder framework adjustments to management measures.

Code of Federal Regulations, 2014 CFR

2014-10-01

... UNITED STATES Management Measures for the Summer Flounder Fisheries § 648.110 Summer flounder framework... 50 Wildlife and Fisheries 12 2014-10-01 2014-10-01 false Summer flounder framework adjustments to management measures. 648.110 Section 648.110 Wildlife and Fisheries FISHERY CONSERVATION AND MANAGEMENT...

Summer Internships for Students through the Air Force Research Laboratory’s Scholars Program

NASA Astrophysics Data System (ADS)

Barnaby, David A.; Hwang, Eunsook; McCullough, Julie A.

2017-01-01

Did you know that the Air Force Research Laboratory (AFRL) has sponsored a summer research program for students for the last 15 years? The AFRL Scholars Program hires high school, undergraduate, and graduate students as payed interns for 12-18 weeks each summer to work on space science and astronomy projects at one of four AFRL locations. By now, more than 1200 students from 34 states have participated. Like advisors in other summertime astrophysics research programs, the AFRL mentors benefit from extra staff for their research efforts at no cost (the Scholars are funded centrally within AFRL). Likewise, the students benefit from summer pay, job experience in a science lab, university housing, and comradery with students from other states. Pay is based on the intern’s academic level with the range being $395/week for high school up to $1115/week for recent Ph.Ds. Benefits not available from other programs include a secret clearance, socializing with a cohort exceeding 100 peers, and exposure to a pathway to a professional science career outside academia. Benefits to AFRL include persuading young people to choose science-technical-engineering-math (STEM) degrees, and roughly 89% of participants show increased interest in STEM courses following their internship.In this poster, we present the advantages to college students (and their mentors) to participating. We outline the topic areas, 60% of which are related to space science and astronomy. We quantify the range of participants’ scholastic level and majors, as well as the impact the program has on stimulating STEM careers and sight stories of students going onto rewarding careers in AFRL. To be eligible, an applicant must be a U.S. citizen, at least 16 years old, available to work a 40-hour business week, agree to a background check, and be enrolled at the time of application. To apply for the summer 2017 program, start at http://afrlscholars.usra.edu.

Science Skills Boot Camp Gets Interns Ready for Research | Poster

Cancer.gov

By Ashley DeVine, Staff Writer Summer interns learned how to read a scientific paper, present a poster, maintain a laboratory notebook, and much more, at the Science Skills Boot Camp in June. “It was a great experience, and it was a great opportunity to meet some of the other interns also working on the campus,” said Alyssa Klein, a Werner H. Kirsten student intern in the Cellular Immunology Group, Laboratory of Molecular Immunoregulation. “The boot camp covered many topics essential to being a good scientist and science researcher.”

Drivers and potential predictability of summer time North Atlantic polar front jet variability

NASA Astrophysics Data System (ADS)

Hall, Richard J.; Jones, Julie M.; Hanna, Edward; Scaife, Adam A.; Erdélyi, Róbert

2017-06-01

The variability of the North Atlantic polar front jet stream is crucial in determining summer weather around the North Atlantic basin. Recent extreme summers in western Europe and North America have highlighted the need for greater understanding of this variability, in order to aid seasonal forecasting and mitigate societal, environmental and economic impacts. Here we find that simple linear regression and composite models based on a few predictable factors are able to explain up to 35 % of summertime jet stream speed and latitude variability from 1955 onwards. Sea surface temperature forcings impact predominantly on jet speed, whereas solar and cryospheric forcings appear to influence jet latitude. The cryospheric associations come from the previous autumn, suggesting the survival of an ice-induced signal through the winter season, whereas solar influences lead jet variability by a few years. Regression models covering the earlier part of the twentieth century are much less effective, presumably due to decreased availability of data, and increased uncertainty in observational reanalyses. Wavelet coherence analysis identifies that associations fluctuate over the study period but it is not clear whether this is just internal variability or genuine non-stationarity. Finally we identify areas for future research.

Summer graduate research program for interns in science and engineering

DOE Office of Scientific and Technical Information (OSTI.GOV)

Lee, C.B.

1992-03-01

The goal of the 10 week graduate intern program was to increase the source of candidates for positions in science and engineering at the Goddard Space Flight Center. Students participating in this program submitted papers on the work they performed over the 10 week period and also filled out questionnaires on the program's effectiveness, their own performance, and suggestions on improvements. The topics covered by the student's papers include: microsoft excel applications; fast aurora zone analysis; injection seeding of a Q-switched alexandrite laser; use of high temperature superconductors; modifications on a communication interface board; modeling of space network activities; predictionmore » of atmospheric ozone content; and applications of industrial engineering.« less

An Evaluation on Iran International Public Health Summer School in Relation to its Efficacy Based on Participants' Experience and Opinions.

PubMed

Parnia, Aidin; Yamani, Nikoo; Zamani, Ahmadreza; Badihian, Shervin; Manouchehri, Navid; Fakhri, Maryam

2017-01-01

A serious challenge to educate health staff for public health is to appear encouraging enough to persuade them for learning issues on this field and implementing new educational methods and innovative ways. Iran International Public Health Summer School (IPHS) made an effort to provide medical sciences students with a fortune to get familiar with and involved in public health. This study intended to evaluate the efficacy of this event. This cross-sectional study was performed in March-April 2015 by the help of an electronic self-administered questionnaire filled out by 49 Iranian participants 6 months after IPHS2014. The questionnaire assessed the main goals in seven main domains: Interest, activities, and general knowledge in the field of public health, general skills, educational methods, educational and executive schedules, and general satisfaction. Average scores of all domains were >3 (the mean), and all were statistically significant. The highest average score belonged to educational methods (3.92) and the lowest was calculated for the item regarding participants' activities on public health (3.5). No significant difference was found between positive answers of individuals who were interested or active in public health prior to the event and those who had no background. We believe IPHS was a unique instance in Public Health Education in Iran. Considering the level of success of this program to reach its goals for both students' with or without any previous background on public health, it is recommended as a general model to be simulated in other developing countries.

Gifted Students' Perceptions of an Accelerated Summer Program and Social Support

ERIC Educational Resources Information Center

Lee, Seon-Young; Olszewski-Kubilius, Paula; Makel, Matthew C.; Putallaz, Martha

2015-01-01

Using survey responses from students who participated in the summer programs at two university-based gifted education institutions, this study examined changes in gifted students' perceptions of their learning environments, accelerated summer programs and regular schools, and social support in lives after participation in the summer programs. Our…

Summer Learning That Sticks

ERIC Educational Resources Information Center

Browne, Daniel

2017-01-01

A new RAND Corporation study shows that voluntary summer programs can benefit children from low-income families, particularly those with high attendance. Programs studied in five school districts had several elements in common: a mix of academics and enrichment activities, certified teachers, small class sizes, full-day programming provided five…

Books for Summer Reading.

ERIC Educational Resources Information Center

Phi Delta Kappan, 1991

1991-01-01

To help replenish educators' supply of ideas, "Kappan" editors suggest several books for summer reading, including many noncurrent titles not specifically on education such as Peter Novick's "That Noble Dream," Joy Kogawa's "Obasan," Zora Neale Hurston's "Their Eyes Were Watching God," Kate Chopin's "The Awakening," Willa Cather's "My Antonia,"…

Summer Youth Forestry Institute

ERIC Educational Resources Information Center

Roesch, Gabrielle E.; Neuffer, Tamara; Zobrist, Kevin

2013-01-01

The Summer Youth Forestry Institute (SYFI) was developed to inspire youth through experiential learning opportunities and early work experience in the field of natural resources. Declining enrollments in forestry and other natural resource careers has made it necessary to actively engage youth and provide them with exposure to careers in these…

Summer Education Program for Neurologically and Physically Handicapped Children. Summer 1975. Evaluation Report.

ERIC Educational Resources Information Center

Ellis, Ronald S.

Evaluated was the Summer Education Program for Neurologically and Physically Handicapped Children, designed to improve the performance of 145 children (6-16 years old) in the following areas--gross motor skills, swimming, fine motor skills, socialization with nonhandicapped peers, and independent daily living skills. The program included the…

An underestimated role of precipitation frequency in regulating summer soil moisture

DOE Office of Scientific and Technical Information (OSTI.GOV)

Wu, Chaoyang; Chen, Jing M.; Pumpanen, Jukka

2012-04-26

Soil moisture induced droughts are expected to become more frequent under future global climate change. Precipitation has been previously assumed to be mainly responsible for variability in summer soil moisture. However, little is known about the impacts of precipitation frequency on summer soil moisture, either interannually or spatially. To better understand the temporal and spatial drivers of summer drought, 415 site yr measurements observed at 75 flux sites world wide were used to analyze the temporal and spatial relationships between summer soil water content (SWC) and the precipitation frequencies at various temporal scales, i.e., from half-hourly, 3, 6, 12 andmore » 24 h measurements. Summer precipitation was found to be an indicator of interannual SWC variability with r of 0.49 (p < 0.001) for the overall dataset. However, interannual variability in summer SWC was also significantly correlated with the five precipitation frequencies and the sub-daily precipitation frequencies seemed to explain the interannual SWC variability better than the total of precipitation. Spatially, all these precipitation frequencies were better indicators of summer SWC than precipitation totals, but these better performances were only observed in non-forest ecosystems. Our results demonstrate that precipitation frequency may play an important role in regulating both interannual and spatial variations of summer SWC, which has probably been overlooked or underestimated. However, the spatial interpretation should carefully consider other factors, such as the plant functional types and soil characteristics of diverse ecoregions.« less

2009 Montana Summer Transportation Institute.

DOT National Transportation Integrated Search

2009-09-01

The Western Transportation Institute hosted a two-week residential Summer Transportation : Institute for sixteen high school students on the Montana State University campus from June : 14 to June 26, 2009. Participants included Montana residents, one...

2013 Montana Summer Transportation Institute.

DOT National Transportation Integrated Search

2013-10-01

The Summer Transportation Institute (STI) hosted by the Western Transportation Institute (WTI) at : Montana State University (MSU) aims to heighten student interest in transportation careers at the pre-college level. The program recruits high school ...

2014 Montana Summer Transportation Institute.

DOT National Transportation Integrated Search

2014-10-01

The Summer Transportation Institute (STI) hosted by the Western Transportation Institute (WTI) at : Montana State University (MSU) aims to heighten student interest in transportation careers at the pre-college level. The program recruits high school ...

Assessment of the uncertainty in future projection for summer climate extremes over the East Asia

NASA Astrophysics Data System (ADS)

Park, Changyong; Min, Seung-Ki; Cha, Dong-Hyun

2017-04-01

Future projections of climate extremes in regional and local scales are essential information needed for better adapting to climate changes. However, future projections hold larger uncertainty factors arising from internal and external processes which reduce the projection confidence. Using CMIP5 (Coupled Model Intercomparison Project Phase 5) multi-model simulations, we assess uncertainties in future projections of the East Asian temperature and precipitation extremes focusing on summer. In examining future projection, summer mean and extreme projections of the East Asian temperature and precipitation would be larger as time. Moreover, uncertainty cascades represent wider scenario difference and inter-model ranges with increasing time. A positive mean-extreme relation is found in projections for both temperature and precipitation. For the assessment of uncertainty factors for these projections, dominant uncertainty factors from temperature and precipitation change as time. For uncertainty of mean and extreme temperature, contributions of internal variability and model uncertainty declines after mid-21st century while role of scenario uncertainty grows rapidly. For uncertainty of mean precipitation projections, internal variability is more important than the scenario uncertainty. Unlike mean precipitation, extreme precipitation shows that the scenario uncertainty is expected to be a dominant factor in 2090s. The model uncertainty holds as an important factor for both mean and extreme precipitation until late 21st century. The spatial changes for the uncertainty factors of mean and extreme projections generally are expressed according to temporal changes of the fraction of total variance from uncertainty factors in many grids of the East Asia. ACKNOWLEDGEMENTS The research was supported by the Korea Meteorological Administration Research and Development program under grant KMIPA 2015-2083 and the National Research Foundation of Korea Grant funded by the Ministry of

Summer outdoor programs: their participants and their effects

Treesearch

Rachel Kaplan

1977-01-01

In a study of the benefits of various summer programs, especially those involving wilderness experiences, the use of pretests for all the groups made possible evaluation of the degree of self-selection as well. Similar tests 6 months later showed the influences of the summer programs themselves. The results suggest that even a relatively short encounter with the out-of...

Discover Summer School: Evaluation Report and Executive Summary

ERIC Educational Resources Information Center

Torgerson, David; Torgerson, Carole; Jefferson, Laura; Buckley, Hannah; Ainsworth, Hannah; Heaps, Clare; Mitchell, Natasha

2014-01-01

The Discover Summer School was a four-week programme which aimed to improve the reading and writing skills of children during the summer between Year 6 and Year 7. The programme was targeted at pupils who had been predicted to achieve below Level 4b in English by the end of Key Stage 2. Pupils meeting the eligibility criteria for the study, and…

Characteristics of carbonaceous particles in Beijing during winter and summer 2003

NASA Astrophysics Data System (ADS)

Yu, J. H.; Chen, T.; Guinot, B.; Cachier, H.; Yu, T.; Liu, W. Q.; Wang, X.

2006-05-01

Campaigns were conducted to measure Organic Carbon (OC) and Elemental Carbon (EC) in PM2.5 during winter and summer 2003 in Beijing. Modest differences of PM2.5 and PM10 mean concentrations were observed between the winter and summer campaigns. The mean PM2.5/PM10 ratio in both seasons was around 60%, indicating PM2.5 contributed significantly to PM10. The mean concentrations of OC and EC in PM2.5 were 11.2+/-7.5 and 6.0+/-5.0 mu g m(-3) for the winter campaign, and 9.4+/-2.1 and 4.3+/-3.0 mu g m(-3) for the summer campaign, respectively. Diurnal concentrations of OC and EC in PM2.5 were found high at night and low during the daytime in winter, and characterized by an obvious minimum in the summer afternoon. The mean OC/EC ratio was 1.87+/-0.09 for winter and 2.39+/-0.49 for summer. The higher OC/EC ratio in summer indicates some formation of Secondary Organic Carbon (SOC). The estimated SOC was 2.8 mu g m(-3) for winter and 4.2 mu g m(-3) for summer.

36 CFR 13.912 - Kantishna area summer season firearm safety zone.

Code of Federal Regulations, 2013 CFR

2013-07-01

... 36 Parks, Forests, and Public Property 1 2013-07-01 2013-07-01 false Kantishna area summer season... Preserve General Provisions § 13.912 Kantishna area summer season firearm safety zone. What is prohibited? No one may fire a gun during the summer season in or across the Kantishna area firearm safety zone...

36 CFR 13.912 - Kantishna area summer season firearm safety zone.

Code of Federal Regulations, 2012 CFR

2012-07-01

... 36 Parks, Forests, and Public Property 1 2012-07-01 2012-07-01 false Kantishna area summer season... Preserve General Provisions § 13.912 Kantishna area summer season firearm safety zone. What is prohibited? No one may fire a gun during the summer season in or across the Kantishna area firearm safety zone...

IRAIT project: future mid-IR operations at Dome C during summer

NASA Astrophysics Data System (ADS)

Tosti, Gino; IRAIT Collaboration

The project IRAIT consists of a robotic mid-infrared telescope that will be hosted at Dome C in the Italian-French Concordia station on the Antarctic Plateau. The telescope was built in collaboration with the PNRA (sectors Technology and Earth-Sun Interaction and Astrophysics). Its focal plane instrumentation is a mid-infrared Camera (5-25 mu m), based on the TIRCAM II prototype, which is the result of a join effort between Institutes of CNR and INAF. International collaborations with French and Spanish Institutes for the construction of a near infrared spectrographic camera have also been started. We present the status of the project and the ongoing developments that will make possible to start infrared observations at Dome C during the summer Antarctic campaign 2005-2006.

2012 Montana Summer Transportation Institute

DOT National Transportation Integrated Search

2012-10-01

The Summer Transportation Institute (STI) hosted by the Western Transportation Institute (WTI) at Montana State University (MSU) aims to heighten student interest in transportation careers at the pre-college level. The program recruits high school st...

Internal Variability-Generated Uncertainty in East Asian Climate Projections Estimated with 40 CCSM3 Ensembles.

PubMed

Yao, Shuai-Lei; Luo, Jing-Jia; Huang, Gang

2016-01-01

Regional climate projections are challenging because of large uncertainty particularly stemming from unpredictable, internal variability of the climate system. Here, we examine the internal variability-induced uncertainty in precipitation and surface air temperature (SAT) trends during 2005-2055 over East Asia based on 40 member ensemble projections of the Community Climate System Model Version 3 (CCSM3). The model ensembles are generated from a suite of different atmospheric initial conditions using the same SRES A1B greenhouse gas scenario. We find that projected precipitation trends are subject to considerably larger internal uncertainty and hence have lower confidence, compared to the projected SAT trends in both the boreal winter and summer. Projected SAT trends in winter have relatively higher uncertainty than those in summer. Besides, the lower-level atmospheric circulation has larger uncertainty than that in the mid-level. Based on k-means cluster analysis, we demonstrate that a substantial portion of internally-induced precipitation and SAT trends arises from internal large-scale atmospheric circulation variability. These results highlight the importance of internal climate variability in affecting regional climate projections on multi-decadal timescales.

Final Report of the Evaluation of the Summer Program for Mentally Retarded Young Adults--Occupational Training Centers. Summer 1970. ESEA Title I.

ERIC Educational Resources Information Center

Nalven, Fredric; Oliver, Adela

The 1970 Summer Program for Mentally Retarded Young Adults Occupational Training Centers program, funded under Title I of the 1965 Elementary Secondary Education Act, was designed to serve the summer educational, prevocational, and social needs of approximately 170 retarded adolescents and young adults. The general objectives of the project were…

Can We Boost College Summer Enrollment Using Behavioral Science?

ERIC Educational Resources Information Center

MDRC, 2017

2017-01-01

MDRC's Center for Applied Behavioral Science (CABS) and Postsecondary Education policy area launched the Encouraging Additional Summer Enrollment (EASE) project in collaboration with Great Lakes Higher Education Corporation & Affiliates and the Ohio Association of Community Colleges. The project aims to increase summer enrollment rates among…

45 CFR 2400.47 - Summer Institute's relationship to fellowship.

Code of Federal Regulations, 2014 CFR

2014-10-01

... 45 Public Welfare 4 2014-10-01 2014-10-01 false Summer Institute's relationship to fellowship. 2400.47 Section 2400.47 Public Welfare Regulations Relating to Public Welfare (Continued) JAMES MADISON MEMORIAL FELLOWSHIP FOUNDATION FELLOWSHIP PROGRAM REQUIREMENTS Graduate Study § 2400.47 Summer Institute's...

45 CFR 2400.50 - Allowances and Summer Institute costs.

Code of Federal Regulations, 2013 CFR

2013-10-01

... 45 Public Welfare 4 2013-10-01 2013-10-01 false Allowances and Summer Institute costs. 2400.50 Section 2400.50 Public Welfare Regulations Relating to Public Welfare (Continued) JAMES MADISON MEMORIAL FELLOWSHIP FOUNDATION FELLOWSHIP PROGRAM REQUIREMENTS Graduate Study § 2400.50 Allowances and Summer...

45 CFR 2400.47 - Summer Institute's relationship to fellowship.

Code of Federal Regulations, 2013 CFR

2013-10-01

... 45 Public Welfare 4 2013-10-01 2013-10-01 false Summer Institute's relationship to fellowship. 2400.47 Section 2400.47 Public Welfare Regulations Relating to Public Welfare (Continued) JAMES MADISON MEMORIAL FELLOWSHIP FOUNDATION FELLOWSHIP PROGRAM REQUIREMENTS Graduate Study § 2400.47 Summer Institute's...

45 CFR 2400.50 - Allowances and Summer Institute costs.

Code of Federal Regulations, 2012 CFR

2012-10-01

... 45 Public Welfare 4 2012-10-01 2012-10-01 false Allowances and Summer Institute costs. 2400.50 Section 2400.50 Public Welfare Regulations Relating to Public Welfare (Continued) JAMES MADISON MEMORIAL FELLOWSHIP FOUNDATION FELLOWSHIP PROGRAM REQUIREMENTS Graduate Study § 2400.50 Allowances and Summer...

45 CFR 2400.47 - Summer Institute's relationship to fellowship.

Code of Federal Regulations, 2012 CFR

2012-10-01

... 45 Public Welfare 4 2012-10-01 2012-10-01 false Summer Institute's relationship to fellowship. 2400.47 Section 2400.47 Public Welfare Regulations Relating to Public Welfare (Continued) JAMES MADISON MEMORIAL FELLOWSHIP FOUNDATION FELLOWSHIP PROGRAM REQUIREMENTS Graduate Study § 2400.47 Summer Institute's...

45 CFR 2400.50 - Allowances and Summer Institute costs.

Code of Federal Regulations, 2014 CFR

2014-10-01

... 45 Public Welfare 4 2014-10-01 2014-10-01 false Allowances and Summer Institute costs. 2400.50 Section 2400.50 Public Welfare Regulations Relating to Public Welfare (Continued) JAMES MADISON MEMORIAL FELLOWSHIP FOUNDATION FELLOWSHIP PROGRAM REQUIREMENTS Graduate Study § 2400.50 Allowances and Summer...

45 CFR 2400.50 - Allowances and Summer Institute costs.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 45 Public Welfare 4 2010-10-01 2010-10-01 false Allowances and Summer Institute costs. 2400.50 Section 2400.50 Public Welfare Regulations Relating to Public Welfare (Continued) JAMES MADISON MEMORIAL FELLOWSHIP FOUNDATION FELLOWSHIP PROGRAM REQUIREMENTS Graduate Study § 2400.50 Allowances and Summer...

45 CFR 2400.47 - Summer Institute's relationship to fellowship.

Code of Federal Regulations, 2011 CFR

2011-10-01

... 45 Public Welfare 4 2011-10-01 2011-10-01 false Summer Institute's relationship to fellowship. 2400.47 Section 2400.47 Public Welfare Regulations Relating to Public Welfare (Continued) JAMES MADISON MEMORIAL FELLOWSHIP FOUNDATION FELLOWSHIP PROGRAM REQUIREMENTS Graduate Study § 2400.47 Summer Institute's...

45 CFR 2400.50 - Allowances and Summer Institute costs.

Code of Federal Regulations, 2011 CFR

2011-10-01

... 45 Public Welfare 4 2011-10-01 2011-10-01 false Allowances and Summer Institute costs. 2400.50 Section 2400.50 Public Welfare Regulations Relating to Public Welfare (Continued) JAMES MADISON MEMORIAL FELLOWSHIP FOUNDATION FELLOWSHIP PROGRAM REQUIREMENTS Graduate Study § 2400.50 Allowances and Summer...

45 CFR 2400.47 - Summer Institute's relationship to fellowship.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 45 Public Welfare 4 2010-10-01 2010-10-01 false Summer Institute's relationship to fellowship. 2400.47 Section 2400.47 Public Welfare Regulations Relating to Public Welfare (Continued) JAMES MADISON MEMORIAL FELLOWSHIP FOUNDATION FELLOWSHIP PROGRAM REQUIREMENTS Graduate Study § 2400.47 Summer Institute's...

Summer Program Aims to Improve Literacy Skills of Black Male Teens

ERIC Educational Resources Information Center

West, Cassandra

2012-01-01

In this article, the author talks about a summer program at the African American Adolescent Male Summer Literacy Institute which aims to improve literacy skills of black male teens. The African American Adolescent Male Summer Literacy Institute is now in its fourth year at the University of Illinois-Chicago (UIC). Alfred Tatum, director of the…

Managing saltcedar after a summer wildfire in the Texas Rolling Plains

Treesearch

Russell Fox; Rob Mitchell; Mike Davin

2001-01-01

Saltcedar (Tamarix spp) has invaded nearly one million acres of riparian ecosystems in the southwestern U.S., displacing many native species. The objectives of this study were to estimate saltcedar mortality to summer wildfire, summer wildfire followed by rollerchopping, and dormant season treatment with 25 percent triclopyr to regrowth following a summer wildfire at...

Methane oxidation in Saanich Inlet during summer stratification

NASA Technical Reports Server (NTRS)

Ward, B. B.; Kilpatrick, K. A.; Wopat, A. E.; Minnich, E. C.; Lidstrom, M. E.

1989-01-01

Saanich Inlet, British Columbia, an fjord on the southeast coast of Vancouver Island, typically stratifies in summer, leading to the formation of an oxic-anoxic interface in the water column and accumulation of methane in the deep water. The results of methane concentration measurements in the water column of the inlet at various times throughout the summer months in 1983 are presented. Methane gradients and calculated diffusive fluxes across the oxic-anoxic interface increased as the summer progressed. Methane distribution and consumption in Saanich Inlet were studied in more detail during August 1986. At this time, a typical summer stratification with an oxic-anoxic interface around 140 m was present. At the interface, steep gradients in nutrient concentrations, bacterial abundance and methane concentration were observed. Methane oxidation was detected in the aerobic surface waters and in the anaerobic deep layer, but highest rates occurred in a narrow layer at the oxic-anoxic interface. Estimated methane oxidation rates were suffcient to consume 100 percent of the methane provided by diffusive flux from the anoxic layer. Methane oxidation is thus a mechanism whereby atmospheric flux from anoxic waters is minimized.

Investigation of summer monsoon rainfall variability in Pakistan

NASA Astrophysics Data System (ADS)

Hussain, Mian Sabir; Lee, Seungho

2016-08-01

This study analyzes the inter-annual and intra-seasonal rainfall variability in Pakistan using daily rainfall data during the summer monsoon season (June to September) recorded from 1980 to 2014. The variability in inter-annual monsoon rainfall ranges from 20 % in northeastern regions to 65 % in southwestern regions of Pakistan. The analysis reveals that the transition of the negative and positive anomalies was not uniform in the investigated dataset. In order to acquire broad observations of the intra-seasonal variability, an objective criterion, the pre-active period, active period and post-active periods of the summer monsoon rainfall have demarcated. The analysis also reveals that the rainfall in June has no significant contribution to the increase in intra-seasonal rainfall in Pakistan. The rainfall has, however, been enhanced in the summer monsoon in August. The rainfall of September demonstrates a sharp decrease, resulting in a high variability in the summer monsoon season. A detailed examination of the intra-seasonal rainfall also reveals frequent amplitude from late July to early August. The daily normal rainfall fluctuates significantly with its maximum in the Murree hills and its minimum in the northwestern Baluchistan.

Early American sunspot drawings from the "year without a summer"

NASA Astrophysics Data System (ADS)

Denig, W. F.; McVaugh, M. R.

2017-07-01

A set of sunspot drawings from the early nineteenth century were discovered in the journals of the Reverend Jonathan Fisher. These drawings were made during a time when abnormally cold weather caused crops in New England to fail due to intermittent frost throughout the summer months of 1816, normally referred to as the "year without a summer." Global changes in weather patterns were the result of the Mount Tambora volcano eruption. Since this association was unknown at the time, there was speculation that the Sun was the cause inspiring the Reverend Fisher to monitor changes in sunspots during the summer of 1816 and continuing into 1817. These sunspot drawings for the summer of 1816 overlap the solar observations of Sir William Hershel.

Saturn, Approaching Northern Summer

NASA Image and Video Library

2016-09-15

Since NASA's Cassini spacecraft arrived at Saturn in mid-2004, the planet's appearance has changed greatly. The shifting angle of sunlight as the seasons march forward has illuminated the giant hexagon-shaped jet stream around the north polar region, and the subtle bluish hues seen earlier in the mission have continued to fade. Earlier views obtained in 2004 and 2009 (see PIA06077 and PIA11667) demonstrate how drastically the illumination has changed. This view shows Saturn's northern hemisphere in 2016, as that part of the planet nears its northern hemisphere summer solstice in May 2017. Saturn's year is nearly 30 Earth years long, and during its long time there, Cassini has observed winter and spring in the north, and summer and fall in the south. The spacecraft will complete its mission just after northern summer solstice, having observed long-term changes in the planet's winds, temperatures, clouds and chemistry. Cassini scanned across the planet and its rings on April 25, 2016, capturing three sets of red, green and blue images to cover this entire scene showing the planet and the main rings. The images were obtained using Cassini's wide-angle camera at a distance of approximately 1.9 million miles (3 million kilometers) from Saturn and at an elevation of about 30 degrees above the ring plane. The view looks toward the sunlit side of the rings from a sun-Saturn-spacecraft angle, or phase angle, of 55 degrees. Image scale on Saturn is about 111 miles (178 kilometers) per pixel. The exposures used to make this mosaic were obtained just prior to the beginning of a 44-hour movie sequence. http://photojournal.jpl.nasa.gov/catalog/PIA21046

45 CFR 2400.49 - Contents of the Summer Institute.

Code of Federal Regulations, 2013 CFR

2013-10-01

... 45 Public Welfare 4 2013-10-01 2013-10-01 false Contents of the Summer Institute. 2400.49 Section 2400.49 Public Welfare Regulations Relating to Public Welfare (Continued) JAMES MADISON MEMORIAL FELLOWSHIP FOUNDATION FELLOWSHIP PROGRAM REQUIREMENTS Graduate Study § 2400.49 Contents of the Summer...

45 CFR 2400.49 - Contents of the Summer Institute.

Code of Federal Regulations, 2014 CFR

2014-10-01

... 45 Public Welfare 4 2014-10-01 2014-10-01 false Contents of the Summer Institute. 2400.49 Section 2400.49 Public Welfare Regulations Relating to Public Welfare (Continued) JAMES MADISON MEMORIAL FELLOWSHIP FOUNDATION FELLOWSHIP PROGRAM REQUIREMENTS Graduate Study § 2400.49 Contents of the Summer...

45 CFR 2400.49 - Contents of the Summer Institute.

Code of Federal Regulations, 2012 CFR

2012-10-01

... 45 Public Welfare 4 2012-10-01 2012-10-01 false Contents of the Summer Institute. 2400.49 Section 2400.49 Public Welfare Regulations Relating to Public Welfare (Continued) JAMES MADISON MEMORIAL FELLOWSHIP FOUNDATION FELLOWSHIP PROGRAM REQUIREMENTS Graduate Study § 2400.49 Contents of the Summer...

45 CFR 2400.49 - Contents of the Summer Institute.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 45 Public Welfare 4 2010-10-01 2010-10-01 false Contents of the Summer Institute. 2400.49 Section 2400.49 Public Welfare Regulations Relating to Public Welfare (Continued) JAMES MADISON MEMORIAL FELLOWSHIP FOUNDATION FELLOWSHIP PROGRAM REQUIREMENTS Graduate Study § 2400.49 Contents of the Summer...

45 CFR 2400.49 - Contents of the Summer Institute.

Code of Federal Regulations, 2011 CFR

2011-10-01

... 45 Public Welfare 4 2011-10-01 2011-10-01 false Contents of the Summer Institute. 2400.49 Section 2400.49 Public Welfare Regulations Relating to Public Welfare (Continued) JAMES MADISON MEMORIAL FELLOWSHIP FOUNDATION FELLOWSHIP PROGRAM REQUIREMENTS Graduate Study § 2400.49 Contents of the Summer...

2015 Montana Summer Transportation Institute.

DOT National Transportation Integrated Search

2015-10-01

The Western Transportation Institute (WTI) at Montana State University (MSU) hosted a Summer : Transportation Institute (STI) from June 14 to June 26, 2015. The aim of the program is to introduce : high school participants to career opportunities in ...

The 1982 NASA/ASEE summer faculty fellowship research program

NASA Technical Reports Server (NTRS)

1982-01-01

Aht NASA/ASEE Summer Faculty Fellowship Research Program conducted at the Marshall Space Flight Center by the University of Alabama at Huntsville, Ala. during the summer of 1982 is described. Abstracts of the Final Reports submitted by the Fellows detailing the results of their research are also presented.

Attitudes of Ohio Vocational Agriculture Teachers toward Summer Programs.

ERIC Educational Resources Information Center

Short, Gary E.; Miller, Larry E.

Because many experiences needed by vocational agriculture students typically occur during the summer, the contracts of Ohio vocational agriculture teachers have been longer than the typical 9-month academic school year. A study examined the attitudes of vocational agriculture instructors throughout Ohio toward summer programs so that policymakers…

Socialization of Adolescents: Cultural Practices in Children's Summer Camp

ERIC Educational Resources Information Center

Demakova, Irina D.; Valeeva, Roza A.; Shipova, Alina V.

2016-01-01

The article describes the relevant aspects of the adolescents' cultural practices in children's summer camp, taking into account their specific characteristics. The summer camp is considered as an educational formation and holistic socio-pedagogical body, designed to create conditions for the development of the person. The criteria for inclusion…

Migration patterns, use of stopover areas, and austral summer movements of Swainson's hawks

USGS Publications Warehouse

Kocher, Michael N.; Fuller, Mark R.; Schueck, Linda S.; Bond, Laura; Bechard, Marc J.; Woodbridge, Brian; Holroyd, Geoff L.; Martell, Mark S.; Banasch, Ursula

2011-01-01

from 1995 to 1998, we tracked movements of adult Swainson's Hawks (Buteo swainsoni), using satellite telemetry to characterize migration, important stopover areas, and movements in the austral summer. we tagged 46 hawks from July to September on their nesting grounds in seven U.S. states and two Canadian provinces. Swainson's Hawks followed three basic routes south on a broad front, converged along the east coast of cen-tral Mexico, and followed a concentrated corridor to a communal area in central Argentina for the austral summer. North of 20° N, southward and northward tracks differed little for individuals from east of the continental divide but differed greatly (up to 1700 km) for individuals from west of the continental divide. Hawks left the breeding grounds mid-August to mid-October; departure dates did not differ by location, year, or sex. Southbound migra-tion lasted 42 to 98 days, northbound migration 51 to 82 days. Southbound, 36% of the Swainson's Hawks departed the nesting grounds nearly 3 weeks earlier than the other radio-marked hawks and made stopovers 9.0–26.0 days long in seven separate areas, mainly in the southern great Plains, southern Arizona and New Mexico, and north-central Mexico. The birds stayed in their nonbreeding range for 76 to 128 days. All used a core area in central Ar-gentina within 23% of the 738 800-km2 austral summer range, where they frequently moved long distances (up to 1600 km). Conservation of Swainson's Hawks must be an international effort that considers habitats used during nesting and non-nesting seasons, including migration stopovers.

Emergency Immigration Education Act Programs: Summer E.S.L. Welcome Plus Program for Students of Limited English Proficiency (LEP), Summer Bilingual Program, and Project Omega. OREA Report.

ERIC Educational Resources Information Center

Duque, Diana L.

This report presents findings of the evaluation by the New York City public school system's Office of Research, Evaluation, and Assessment of three programs (Summer E.S.L. Welcome Plus, Summer Bilingual, and Project Omega) for immigrant students. The Summer E.S.L. (English as a Second Language) Welcome Plus program operated at 19 sites in New York…

Lactate dehydrogenase downregulation mediates the inhibitory effect of diallyl trisulfide on proliferation, metastasis, and invasion in triple-negative breast cancer.

PubMed

Cheng, Shi-Yann; Yang, Yao-Chih; Ting, Kuan-Lun; Wen, Su-Ying; Viswanadha, Vijaya Padma; Huang, Chih-Yang; Kuo, Wei-Wen

2017-04-01

The Warburg effect plays a critical role in tumorigenesis, suggesting that specific agents targeting Warburg effect key proteins may be a promising strategy for cancer therapy. Previous studies have shown that diallyl trisulfide (DATS) inhibits proliferation of breast cancer cells by inducing apoptosis in vitro and in vivo. However, whether the Warburg effect is involved with the apoptosis-promoting action of DATS is unclear. Here, we show that the action of DATS is associated with downregulation of lactate dehydrogenase A (LDHA), an essential protein of the Warburg effect whose upregulation is closely related to tumorigenesis. Interestingly, inhibition of the Warburg effect by DATS in breast cancer cells did not greatly affect normal cells. Furthermore, DATS inhibited growth of breast cancer cells, particularly in MDA-MB-231, a triple-negative breast cancer (TNBC) cell, and reduced proliferation and migration; invasion was reversed by over-expression of LDHA. These data suggest that DATS inhibits breast cancer growth and aggressiveness through a novel pathway targeting the key enzyme of the Warburg effect. Our study shows that LDHA downregulation is involved in the apoptotic effect of DATS on TNBC. © 2016 Wiley Periodicals, Inc. Environ Toxicol 32: 1390-1398, 2017. © 2016 Wiley Periodicals, Inc.

Help for the Summer

ERIC Educational Resources Information Center

Greifner, Laura

2006-01-01

Throngs of people cover the concrete walkways of Dorney Park, an amusement park about an hour north of Philadelphia. Employees under the age of 18 make up about 40 percent of the park's summer workforce, and, park officials say, are even more crucial to its operations later in the season, when college-student employees go back to school and…

Potential impacts of the Arctic on interannual and interdecadal summer precipitation over China

DOE Office of Scientific and Technical Information (OSTI.GOV)

Li, Yuefeng; Leung, Lai-Yung R.

2013-02-01

After the end of the 1970s, there has been a tendency for enhanced summer precipitation over South China and the Yangtze River valley and drought over North China and Northeastern China. Coincidentally, Arctic ice concentration has decreased since the late 1970s, with larger reduction in summer than spring. However, the Arctic warming is more significant in spring than summer, suggesting that spring Arctic conditions could be more important in their remote impacts. This study investigates the potential impacts of the Arctic on summer precipitation in China. The leading spatial patterns and time coefficients of the unfiltered, interannual, and interdecadal precipitationmore » (1960-2008) modes were analyzed and compared using empirical orthogonal function (EOF) analysis, which shows that the first three EOFs can capture the principal precipitation patterns (northern, central and southern patterns) over eastern China. Regression of the Arctic spring and summer temperature onto the time coefficients of the leading interannual and interdecadal precipitation modes shows that interdecadal summer precipitation in China is related to the Arctic spring warming, but the relationship with Arctic summer temperature is weak. Moreover, no notable relationships were found between the first three modes of interannual precipitation and Arctic spring or summer temperatures. Finally, correlations between summer precipitation and the Arctic Oscillation (AO) index from January to August were investigated, which indicate that summer precipitation in China correlates with AO only to some extent. Overall, this study suggests important relationships between the Arctic spring temperature and summer precipitation over China at the interdecadal time scale.« less

Children's Moderate to Vigorous Physical Activity Attending Summer Day Camps.

PubMed

Brazendale, Keith; Beets, Michael W; Weaver, R Glenn; Chandler, Jessica L; Randel, Allison B; Turner-McGrievy, Gabrielle M; Moore, Justin B; Huberty, Jennifer L; Ward, Dianne S

2017-07-01

National physical activity standards call for all children to accumulate 60 minutes/day of moderate to vigorous physical activity (MVPA). The contribution of summer day camps toward meeting this benchmark is largely unknown. The purpose of this study was to provide estimates of children's MVPA during summer day camps. Children (n=1,061, 78% enrollment; mean age, 7.8 years; 46% female; 65% African American; 48% normal weight) from 20 summer day camps wore ActiGraph GT3x+ accelerometers on the wrist during camp hours for up to 4 non-consecutive days over the summer of 2015 (July). Accumulated MVPA at the 25th, 50th, and 75th percentile of the distribution was estimated using random-effects quantile regression. All models were estimated separately for boys and girls and controlled for wear time. Minutes of MVPA were dichotomized to ≥60 minutes/day of MVPA or <60 minutes/day to estimate percentage of boys and girls meeting the 60 minutes/day guideline. All data were analyzed in spring 2016. Across the 20 summer day camps, boys (n=569) and girls (n=492) accumulated a median of 96 and 82 minutes/day of MVPA, respectively. The percentage of children meeting 60 minutes/day of MVPA was 80% (range, 41%-94%) for boys and 73% (range, 30%-97%) for girls. Summer day camps are a setting where a large portion of boys and girls meet daily physical activity guidelines. Public health practitioners should focus efforts on making summer day camps accessible for children in the U.S. Copyright © 2017 American Journal of Preventive Medicine. Published by Elsevier Inc. All rights reserved.

COMBINATION SUMMER KITCHEN AND SMOKE HOUSE, VIEW TO EAST/NORTHEAST ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

COMBINATION SUMMER KITCHEN AND SMOKE HOUSE, VIEW TO EAST/NORTHEAST - Kiel Farmstead, Summer Kitchen & Smokehouse, East side State Route 4, one half mile south of U.S. Route 64, Mascoutah, St. Clair County, IL

The year without a summer

NASA Astrophysics Data System (ADS)

Luterbacher, J.; Pfister, C.

2015-04-01

The 1815 eruption of Tambora caused an unusually cold summer in much of Europe in 1816. The extreme weather led to poor harvests and malnutrition, but also demonstrated the capability of humans to adapt and help others in worse conditions.

50 CFR 648.107 - Conservation equivalent measures for the summer flounder fishery.

Code of Federal Regulations, 2013 CFR

2013-10-01

... summer flounder fishery. 648.107 Section 648.107 Wildlife and Fisheries FISHERY CONSERVATION AND... NORTHEASTERN UNITED STATES Management Measures for the Summer Flounder Fisheries § 648.107 Conservation equivalent measures for the summer flounder fishery. (a) The Regional Administrator has determined that the...

50 CFR 648.107 - Conservation equivalent measures for the summer flounder fishery.

Code of Federal Regulations, 2014 CFR

2014-10-01

... summer flounder fishery. 648.107 Section 648.107 Wildlife and Fisheries FISHERY CONSERVATION AND... NORTHEASTERN UNITED STATES Management Measures for the Summer Flounder Fisheries § 648.107 Conservation equivalent measures for the summer flounder fishery. (a) The Regional Administrator has determined that the...

50 CFR 648.107 - Conservation equivalent measures for the summer flounder fishery.

Code of Federal Regulations, 2010 CFR

2010-10-01

... summer flounder fishery. 648.107 Section 648.107 Wildlife and Fisheries FISHERY CONSERVATION AND... NORTHEASTERN UNITED STATES Management Measures for the Summer Flounder Fisheries § 648.107 Conservation equivalent measures for the summer flounder fishery. (a) The Regional Administrator has determined that the...

The role of the winter residual circulation in the summer mesopause regions in WACCM

NASA Astrophysics Data System (ADS)

Sanne Kuilman, Maartje; Karlsson, Bodil

2018-03-01

High winter planetary wave activity warms the summer polar mesopause via a link between the two hemispheres. Complex wave-mean-flow interactions take place on a global scale, involving sharpening and weakening of the summer zonal flow. Changes in the wind shear occasionally generate flow instabilities. Additionally, an altering zonal wind modifies the breaking of vertically propagating gravity waves. A crucial component for changes in the summer zonal flow is the equatorial temperature, as it modifies latitudinal gradients. Since several mechanisms drive variability in the summer zonal flow, it can be hard to distinguish which one is dominant. In the mechanism coined interhemispheric coupling, the mesospheric zonal flow is suggested to be a key player for how the summer polar mesosphere responds to planetary wave activity in the winter hemisphere. We here use the Whole Atmosphere Community Climate Model (WACCM) to investigate the role of the summer stratosphere in shaping the conditions of the summer polar mesosphere. Using composite analyses, we show that in the absence of an anomalous summer mesospheric temperature gradient between the equator and the polar region, weak planetary wave forcing in the winter would lead to a warming of the summer mesosphere region instead of a cooling, and vice versa. This is opposing the temperature signal of the interhemispheric coupling that takes place in the mesosphere, in which a cold and calm winter stratosphere goes together with a cold summer mesopause. We hereby strengthen the evidence that the variability in the summer mesopause region is mainly driven by changes in the summer mesosphere rather than in the summer stratosphere.

Developmental Summer Bridge Programs. What Works Clearinghouse™ Intervention Report

ERIC Educational Resources Information Center

What Works Clearinghouse, 2015

2015-01-01

Developmental summer bridge programs are designed to reduce the need for developmental education in college by providing students with accelerated instruction in areas where additional knowledge and skills are needed to help them succeed in higher education. The WWC identified one study of developmental summer bridge programs that meets WWC…

Insights into the Drought and Heat Avoidance Mechanism in Summer-Dormant Mediterranean Tall Fescue

PubMed Central

Missaoui, Ali M.; Malinowski, Dariusz P.; Pinchak, William E.; Kigel, Jaime

2017-01-01

Summer dormancy is an evolutionary response that some perennial cool-season grasses adopted as an avoidance strategy to escape summer drought and heat. It is correlated with superior survival after severe summer droughts in many perennial grass species originating from Mediterranean environments. Understanding the genetic mechanism and environmental determinants of summer dormancy is important for interpreting the evolutionary history of seasonal dormancy and for the development of genomic tools to improve the efficiency of genetic selection for this important trait. The objectives of this research are to assess morphological and biochemical attributes that seem to be specific for the characterization of summer dormancy in tall fescue, and to validate the hypothesis that genes underlying stem determinacy might be involved in the mechanism of summer dormancy. Our results suggest that vernalization is an important requirement in the onset of summer dormancy in tall fescue. Non-vernalized tall fescue plants do not exhibit summer dormancy as vernalized plants do and behave more like summer-active types. This is manifested by continuation of shoot growth and high root activity in water uptake during summer months. Therefore, summer dormancy in tall fescue should be tested only in plants that underwent vernalization and are not subjected to water deficit during summer months. Total phenolic concentration in tiller bases (antioxidants) does not seem to be related to vernalization. It is most likely an environmental response to protect meristems from oxidative stress. Sequence analysis of the TFL1 homolog CEN gene from tall fescue genotypes belonging to summer-dormant and summer-active tall fescue types showed a unique deletion of three nucleotides specific to the dormant genotypes. Higher tiller bud numbers in dormant plants that were not allowed to flower and complete the reproductive cycle, confirmed that stem determinacy is a major component in the mechanism of summer

Insights into the Drought and Heat Avoidance Mechanism in Summer-Dormant Mediterranean Tall Fescue.

PubMed

Missaoui, Ali M; Malinowski, Dariusz P; Pinchak, William E; Kigel, Jaime

2017-01-01

Summer dormancy is an evolutionary response that some perennial cool-season grasses adopted as an avoidance strategy to escape summer drought and heat. It is correlated with superior survival after severe summer droughts in many perennial grass species originating from Mediterranean environments. Understanding the genetic mechanism and environmental determinants of summer dormancy is important for interpreting the evolutionary history of seasonal dormancy and for the development of genomic tools to improve the efficiency of genetic selection for this important trait. The objectives of this research are to assess morphological and biochemical attributes that seem to be specific for the characterization of summer dormancy in tall fescue, and to validate the hypothesis that genes underlying stem determinacy might be involved in the mechanism of summer dormancy. Our results suggest that vernalization is an important requirement in the onset of summer dormancy in tall fescue. Non-vernalized tall fescue plants do not exhibit summer dormancy as vernalized plants do and behave more like summer-active types. This is manifested by continuation of shoot growth and high root activity in water uptake during summer months. Therefore, summer dormancy in tall fescue should be tested only in plants that underwent vernalization and are not subjected to water deficit during summer months. Total phenolic concentration in tiller bases (antioxidants) does not seem to be related to vernalization. It is most likely an environmental response to protect meristems from oxidative stress. Sequence analysis of the TFL1 homolog CEN gene from tall fescue genotypes belonging to summer-dormant and summer-active tall fescue types showed a unique deletion of three nucleotides specific to the dormant genotypes. Higher tiller bud numbers in dormant plants that were not allowed to flower and complete the reproductive cycle, confirmed that stem determinacy is a major component in the mechanism of summer

PVAMU/XULA/BCM Summer Prostate Cancer Research Program

DTIC Science & Technology

2017-10-01

AWARD NUMBER: W81XWH-15-1-0677 TITLE: PVAMU/XULA/BCM Summer Prostate Cancer Research Program PRINCIPAL INVESTIGATOR: Nancy L. Weigel...Medical Research and Materiel Command Fort Detrick, Maryland 21702-5012 DISTRIBUTION STATEMENT: Approved for Public Release; Distribution Unlimited...PVAMU/XULA/BCM Summer Prostate Cancer Research Program 5b. GRANT NUMBER W81XWH-15-1-0677 5c. PROGRAM ELEMENT NUMBER 6. AUTHOR(S) Nancy L. Weigel

Contextual view of summer kitchen, showing blacksmith shop downhill at ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

Contextual view of summer kitchen, showing blacksmith shop downhill at right and cottage at center (between the trees); camera facing northeast - Lemmon-Anderson-Hixson Ranch, Summer Kitchen, 11220 North Virginia Street, Reno, Washoe County, NV

SUMMER KITCHEN AND SMOKE HOUSE AND HOUSE, VIEW TO WEST/ ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

SUMMER KITCHEN AND SMOKE HOUSE AND HOUSE, VIEW TO WEST/ SOUTHWEST - Kiel Farmstead, Summer Kitchen & Smokehouse, East side State Route 4, one half mile south of U.S. Route 64, Mascoutah, St. Clair County, IL

PREFACE: 27th Summer School and International Symposium on the Physics of Ionized Gases (SPIG 2014)

NASA Astrophysics Data System (ADS)

Marić, Dragana; Milosavljević, Aleksandar R.; Mijatović, Zoran

2014-12-01

This volume of Journal of Physics: Conference Series contains a selection of papers presented at the 27th Summer School and International Symposium on the Physics of Ionized Gases - SPIG 2014, as General Invited Lectures, Topical Invited Lectures, Progress Reports and associated Workshop Lectures. The conference was held in Belgrade, Serbia, from 26-29 August 2014 at the Serbian Academy of Sciences and Arts. It was organized by the Institute of Physics Belgrade, University of Belgrade and Serbian Academy of Sciences and Arts, under the auspices of the Ministry of Education, Science and Technological Development, Republic of Serbia. A rare virtue of a SPIG conference is that it covers a wide range of topics, bringing together leading scientists worldwide to present and discuss state-of-the art research and the most recent applications, thus stimulating a modern approach of interdisciplinary science. The Invited lectures and Contributed papers are related to the following research fields: 1. Atomic Collision Processes (Electron and Photon Interactions with Atomic Particles, Heavy Particle Collisions, Swarms and Transport Phenomena) 2. Particle and Laser Beam Interactions with Solids (Atomic Collisions in Solids, Sputtering and Deposition, Laser and Plasma Interaction with Surfaces) 3. Low Temperature Plasmas (Plasma Spectroscopy and other Diagnostic Methods, Gas Discharges, Plasma Applications and Devices) 4. General Plasmas (Fusion Plasmas, Astrophysical Plasmas and Collective Phenomena) Additionally, the 27th SPIG encompassed three workshops that are closely related to the scope of the conference: • The Workshop on Dissociative Electron Attachment (DEA) - Chaired by Prof. Nigel J Mason, OBE, The Open University, United Kingdom • The Workshop on X-ray Interaction with Biomolecules in Gas Phase (XiBiGP), Chaired by Dr. Christophe Nicolas, Synchrotron SOLEIL, France • The 3rd International Workshop on Non-Equilibrium Processes (NonEqProc) - Chaired by Prof

Sizzling Summer Reading Programs for Young Adults: Second Edition

ERIC Educational Resources Information Center

Kan, Katharine L.

2006-01-01

Summer reading programs are a staple in libraries nationwide and provide a valuable service: keeping teens productive and occupied when they are no longer busy in school. Producing creative programs at the library can be challenging when faced with this easily distracted teen demographic; that's where "Sizzling Summer Reading Programs" steps in.…

Summer HILT Experience: ESL and SSL for Elementary School.

ERIC Educational Resources Information Center

Garcia, Marilyn; Grady, Karen

A high intensity language training (HILT) summer program in English as a second language and Spanish as a second language offered to second through eighth grade students in the North Monterey County Unified School District (California) during the summers of 1982 and 1983 is described. The program funding, design, admission, development, and…

Read Hard, Play Later: Putting Summer Reading into Action.

ERIC Educational Resources Information Center

Wemett, Lisa C.; Bolan, Kimberly

1998-01-01

Provides an overview of "Read on the Wild Side," a summer reading program for young adults established by the Webster (New York) Public Library, and "Read Hard, Play Later," a young adult summer reading program of the Pioneer Library System (New York). Highlights include reading logs, T-shirts, publicity, program evaluation,…

The Forgotten Summer: Does the Offer of College Counseling after High School Mitigate Summer Melt among College-Intending, Low-Income High School Graduates?

ERIC Educational Resources Information Center

Castleman, Benjamin L.; Page, Lindsay C.; Schooley, Korynn

2014-01-01

Despite decades of policy intervention to increase college entry and success among low-income students, considerable gaps by socioeconomic status remain. To date, policymakers have overlooked the summer after high school as an important time period in students' transition to college, yet recent research documents high rates of summer attrition…

The Encouragement of Summer Enrollment.

ERIC Educational Resources Information Center

Montgomery, David C.

1982-01-01

Florida's unsuccessful statewide, 20-year effort to encourage summer enrollment began with conversion from a semester to trimester calendar, then to a quarter system, and included such incentives as tuition reduction, dormitory rate reduction, adoption of full course schedules, and mandatory enrollment. (MSE)

20 CFR 664.610 - How is the summer employment opportunities element administered?

Code of Federal Regulations, 2012 CFR

2012-04-01

... 20 Employees' Benefits 4 2012-04-01 2012-04-01 false How is the summer employment opportunities..., DEPARTMENT OF LABOR (CONTINUED) YOUTH ACTIVITIES UNDER TITLE I OF THE WORKFORCE INVESTMENT ACT Summer Employment Opportunities § 664.610 How is the summer employment opportunities element administered? Chief...

20 CFR 664.610 - How is the summer employment opportunities element administered?

Code of Federal Regulations, 2013 CFR

2013-04-01

... 20 Employees' Benefits 4 2013-04-01 2013-04-01 false How is the summer employment opportunities..., DEPARTMENT OF LABOR (CONTINUED) YOUTH ACTIVITIES UNDER TITLE I OF THE WORKFORCE INVESTMENT ACT Summer Employment Opportunities § 664.610 How is the summer employment opportunities element administered? Chief...

20 CFR 664.610 - How is the summer employment opportunities element administered?

Code of Federal Regulations, 2014 CFR

2014-04-01

... 20 Employees' Benefits 4 2014-04-01 2014-04-01 false How is the summer employment opportunities..., DEPARTMENT OF LABOR (CONTINUED) YOUTH ACTIVITIES UNDER TITLE I OF THE WORKFORCE INVESTMENT ACT Summer Employment Opportunities § 664.610 How is the summer employment opportunities element administered? Chief...

20 CFR 664.610 - How is the summer employment opportunities element administered?

Code of Federal Regulations, 2011 CFR

2011-04-01

... 20 Employees' Benefits 3 2011-04-01 2011-04-01 false How is the summer employment opportunities..., DEPARTMENT OF LABOR YOUTH ACTIVITIES UNDER TITLE I OF THE WORKFORCE INVESTMENT ACT Summer Employment Opportunities § 664.610 How is the summer employment opportunities element administered? Chief elected officials...

50 CFR 648.107 - Conservation equivalent measures for the summer flounder fishery.

Code of Federal Regulations, 2011 CFR

2011-10-01

... summer flounder fishery. 648.107 Section 648.107 Wildlife and Fisheries FISHERY CONSERVATION AND... NORTHEASTERN UNITED STATES Management Measures for the Summer Flounder Fisheries § 648.107 Conservation equivalent measures for the summer flounder fishery. Link to an amendment published at 76 FR 60629, Sept. 29...

20 CFR 664.610 - How is the summer employment opportunities element administered?

Code of Federal Regulations, 2010 CFR

2010-04-01

... 20 Employees' Benefits 3 2010-04-01 2010-04-01 false How is the summer employment opportunities..., DEPARTMENT OF LABOR YOUTH ACTIVITIES UNDER TITLE I OF THE WORKFORCE INVESTMENT ACT Summer Employment Opportunities § 664.610 How is the summer employment opportunities element administered? Chief elected officials...

2016 SUMMER BLAST PICNIC

NASA Image and Video Library

2016-06-09

MARSHALL SPACE FLIGHT CENTER DIRECTOR TODD MAY CASTS HIS BALLOT IN THE HOMEMADE ICE CREAM CONTEST DURING THE GREAT EXCHANGE SUMMER BLAST SOCIAL, PRESENTED JUNE 9 BY THE MARSHALL EXCHANGE. THE EXCHANGE IS A NON-APPROPRIATED-FUND ACTIVITY THAT AIMS TO CONTRIBUTE TO THE WELFARE, EFFICIENCY AND MORALE OF MARSHALL TEAM MEMBERS, OTHER GOVERNMENT PERSONNEL, RETIRED NASA EMPLOYEES AND THEIR FAMILIES.

College-Admissions Experts Differ on Value of Summer Employment

ERIC Educational Resources Information Center

Greifner, Laura

2006-01-01

When it comes to getting into college, admissions experts differ on the value of summer jobs compared with that of academic programs, unpaid internships, foreign travel, or other activities designed to look good on a college application. This article presents some views from these experts regarding the value of students' summer jobs. They believe,…

A Description and Evaluation of the 1979 Summer Training Workshop. Roosevelt University and the Chicago Board of Education Teacher Corps Project--Program '78.

ERIC Educational Resources Information Center

Asser, Eliot; And Others

A report is given of a fifteen-day summer workshop sponsored by the Teacher Corps. The workshop was held in Chicago, Illinois and involved faculty from the Hyde Park Career Academy, Dumas Elementary School, representatives from the Community Council, and interns from the Teacher Corps Member Training Institute. The focus of the workshop was on…

Increased aerosol content in the atmosphere over Ukraine during summer 2010

NASA Astrophysics Data System (ADS)

Galytska, Evgenia; Danylevsky, Vassyl; Hommel, René; Burrows, John P.

2018-04-01

In this paper we assessed the influence of biomass burning during forest fires throughout summer (1 June-31 August) 2010 on aerosol abundance, dynamics, and its properties over Ukraine. We also considered influences and effects over neighboring countries: European Russia, Estonia, Belarus, Poland, Moldova, and Romania. We used MODIS satellite instrument data to study fire distribution. We also used ground-based remote measurements from the international sun photometer network AERONET plus MODIS and CALIOP satellite instrument data to determine the aerosol content and optical properties in the atmosphere over Eastern Europe. We applied the HYSPLIT model to investigate atmospheric dynamics and model pathways of particle transport. As with previous studies, we found that the highest aerosol content was observed over Moscow in the first half of August 2010 due to the proximity of the most active fires. Large temporal variability of the aerosol content with pronounced pollution peaks during 7-17 August was observed at the Ukrainian (Kyiv and Sevastopol), Belarusian (Minsk), Estonian (Toravere), and Romanian (Bucharest) AERONET sites. We analyzed aerosol spatiotemporal distribution over Ukraine using MODIS AOD 550 nm and further compared with the Kyiv AERONET site sun photometer measurements; we also compared CALIOP AOD 532 nm with MODIS AOD data. We analyzed vertical distribution of aerosol extinction at 532 nm, retrieved from CALIOP measurements, for the territory of Ukraine at locations where high AOD values were observed during intense fires. We estimated the influence of fires on the spectral single scattering albedo, size distribution, and complex refractive indices using Kyiv AERONET measurements performed during summer 2010. In this study we showed that the maximum AOD in the atmosphere over Ukraine recorded in summer 2010 was caused by particle transport from the forest fires in Russia. Those fires caused the highest AOD 500 nm over the Kyiv site, which in

It's Time for Summer: An Analysis of Recent Policy and Funding Opportunities

ERIC Educational Resources Information Center

Fairchild, Ron; Smink, Jeff; Stewart, Ashley B.

2009-01-01

The National Summer Learning Association is the only national organization that focuses exclusively on learning during the summer months. It works to ensure that children and youth in high-poverty communities have access to quality summer learning opportunities that support their academic performance and healthy development through hands-on…

NASA-ASEE Summer Faculty Fellowship Program at NASA Lewis Research Center

NASA Technical Reports Server (NTRS)

Prahl, Joseph M.; Keith, Theo G., Jr.; Montegani, Francis J.

1996-01-01

During the summer of 1996, a ten-week Summer Faculty Fellowship Program was conducted at the NASA Lewis Research Center (LeRC) in collaboration with Case Western Reserve University (CWRU), and the Ohio Aerospace Institute (OAI). This is the thirty-third summer of this program at Lewis. It was one of nine summer programs sponsored by NASA in 1996, at various field centers under the auspices of the American Society for Engineering Education (ASEE). The objectives of the program are: (1) to further the professional knowledge of qualified engineering and science educators, (2) to stimulate an exchange of ideas between participants and NASA, (3) to enrich and refresh the research activities of participants' institutions. (4) to contribute to the research objectives of LeRC. This report is intended to recapitulate the activities comprising the 1996 Lewis Summer Faculty Fellowship Program, to summarize evaluations by the participants, and to make recommendations regarding future programs.

Mercury accumulation and the mercury-PCB-sex interaction in summer flounder

USGS Publications Warehouse

Madenjian, Charles P.; Jensen, Olaf P.; Krabbenhoft, David P.; DeWild, John F.; Ogorek, Jacob M.; Vastano, Anthony R.

2016-01-01

Patterns in the relative differences in contaminant concentrations between the sexes of mature fish may reveal important behavioral and physiological differences between the sexes. We determined whole-fish total mercury (Hg) concentrations in 23 female summer flounder (Paralichthys dentatus) and 27 male summer flounder from New Jersey coastal waters. To estimate the change in Hg concentration due to release of eggs at spawning, Hg concentration in the somatic tissue and ovaries of 5 of the 23 female summer flounder were also determined. To ascertain whether most of the Hg in the summer flounder was methylmercury (MeHg), whole-fish MeHg concentrations were determined in all 50 summer flounder. Whole-fish Hg concentrations averaged 113 ng/g for females and 111 ng/g for males. Thus, females were 2% higher in Hg concentration than males, on average, but the difference was not statistically significant. Based on Hg determinations in the somatic tissue and ovaries, we predicted that Hg concentration of females would increase by 3.6%, on average, immediately after spawning due to release of eggs. On average, 92% of the Hg in the summer flounder was MeHg. To determine whether the effect of sex on Hg concentration was significantly different from the effect of sex on polychlorinated biphenyl (PCB) concentration, we paired our Hg determinations with PCB determinations from a previous study, and applied regression analysis. Sex significantly interacted with contaminant type (Hg or PCBs), as males were 43% higher in PCB concentration than females, whereas females were 2% higher in Hg concentration than males. Males eliminating Hg from their bodies at a faster rate than females was a likely explanation for this discrepancy between the two contaminant types. Overall, the Hg and PCB concentrations in the summer flounder were relatively low, and therefore our findings also had implications for continued operation of the summer flounder fishery.