Sample records for washington university genome
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2005-01-01
Sequencing of the human genome has ushered in a new era of biology. The technologies developed to facilitate the sequencing of the human genome are now being applied to the sequencing of other genomes. In 2004, a partnership was formed between Washington University School of Medicine Genome Sequencing Center's Outreach Program and Washington University Department of Biology Science Outreach to create a video tour depicting the processes involved in large-scale sequencing. “Sequencing a Genome: Inside the Washington University Genome Sequencing Center” is a tour of the laboratory that follows the steps in the sequencing pipeline, interspersed with animated explanations of the scientific procedures used at the facility. Accompanying interviews with the staff illustrate different entry levels for a career in genome science. This video project serves as an example of how research and academic institutions can provide teachers and students with access and exposure to innovative technologies at the forefront of biomedical research. Initial feedback on the video from undergraduate students, high school teachers, and high school students provides suggestions for use of this video in a classroom setting to supplement present curricula. PMID:16341256
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ERIC Educational Resources Information Center
Flowers, Susan K.; Easter, Carla; Holmes, Andrea; Cohen, Brian; Bednarski, April E.; Mardis, Elaine R.; Wilson, Richard K.; Elgin, Sarah C. R.
2005-01-01
Sequencing of the human genome has ushered in a new era of biology. The technologies developed to facilitate the sequencing of the human genome are now being applied to the sequencing of other genomes. In 2004, a partnership was formed between Washington University School of Medicine Genome Sequencing Center's Outreach Program and Washington…
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Magee, J; Gordon, J I; Whelan, A
2001-08-01
The human genome project is revolutionizing medical research and the practice of clinical medicine. To understand and participate in this revolution, physicians must be fluent in human genomics and bioinformatics. At Washington University School of Medicine (WUSM), the authors designed a module for teaching these skills to first-year students. The module uses clinical cases as a platform for accessing information stored in GenBank, Online Mendelian Inheritance in Man (OMIM), and PubMed databases at the National Center for Biotechnology Information (NCBI). This module, which is also designed to reinforce problem-solving skills, has been integrated into WUSM's first-year medical genetics course.
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Federal Register 2010, 2011, 2012, 2013, 2014
2012-02-27
...: Central Washington University Department of Anthropology, Ellensburg, WA AGENCY: National Park Service, Interior. ACTION: Notice. SUMMARY: The Central Washington University Department of Anthropology has... Central Washington University Department of Anthropology. Repatriation of the human remains and associated...
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Draft Genome of Janthinobacterium sp. RA13 Isolated from Lake Washington Sediment
McTaggart, Tami L.; Shapiro, Nicole; Woyke, Tanja
2015-01-01
Sequencing the genome of Janthinobacterium sp. RA13 from Lake Washington sediment is announced. From the genome content, a versatile life-style is predicted, but not bona fide methylotrophy. With the availability of its genomic sequence, Janthinobacterium sp. RA13 presents a prospective model for studying microbial communities in lake sediments. PMID:25676775
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NREL, University of Washington Scientists Elevate Quantum Dot Solar Cell
World Record to 13.4 Percent | NREL | News | NREL NREL, University of Washington Scientists Elevate Quantum Dot Solar Cell World Record to 13.4 Percent News Release: NREL, University of Washington Scientists Elevate Quantum Dot Solar Cell World Record to 13.4 Percent October 27, 2017 Researchers at the
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Federal Register 2010, 2011, 2012, 2013, 2014
2010-08-24
... DEPARTMENT OF THE INTERIOR National Park Service Notice of Inventory Completion: Thomas Burke Memorial Washington State Museum, University of Washington, Seattle, WA AGENCY: National Park Service... of the Thomas Burke Memorial Washington State Museum (Burke Museum), University of Washington...
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Laptop Circulation at Eastern Washington University
ERIC Educational Resources Information Center
Munson, Doris; Malia, Elizabeth
2008-01-01
In 2001, Eastern Washington University's Libraries began a laptop circulation program with seventeen laptops. Today, there are 150 laptops in the circulation pool, as well as seventeen digital cameras, eleven digital handycams, and thirteen digital projectors. This article explains how the program has grown to its present size, the growing pains…
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Federal Register 2010, 2011, 2012, 2013, 2014
2010-06-28
... made by the Burke Museum professional staff in consultation with representatives of the Lummi Tribe of... Memorial Washington State Museum, University of Washington, Seattle, WA AGENCY: National Park Service... of the Thomas Burke Memorial Washington State Museum (Burke Museum), University of Washington...
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Federal Register 2010, 2011, 2012, 2013, 2014
2012-04-19
... of Anthropology at Washington State University, Pullman, WA AGENCY: National Park Service, Interior. ACTION: Notice. SUMMARY: The Museum of Anthropology at Washington State University has completed an... contact the Museum of Anthropology at Washington State University. Repatriation of the human remains to...
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Federal Register 2010, 2011, 2012, 2013, 2014
2010-03-25
... Washington, Department of Anthropology, Seattle, WA AGENCY: National Park Service, Interior. ACTION: Notice... University of Washington, Department of Anthropology, Seattle, WA. The human remains were removed from... University of Washington, Department of Anthropology and Burke Museum staff in consultation with...
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Federal Register 2010, 2011, 2012, 2013, 2014
2010-07-19
... Anthropology, Washington State University Pullman, WA AGENCY: National Park Service, Interior. ACTION: Notice... associated funerary objects in the possession and control of the Museum of Anthropology, Washington State... made by Museum of Anthropology, Washington State University, professional staff in consultation with...
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Federal Register 2010, 2011, 2012, 2013, 2014
2012-08-24
... the human remains was made by the Burke Museum professional staff in consultation with representatives... Inventory Completion: Thomas Burke Memorial Washington State Museum, University of Washington, Seattle, WA... State Museum (Burke Museum), University of Washington, has completed an inventory of human remains, in...
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Federal Register 2010, 2011, 2012, 2013, 2014
2013-07-30
... associated funerary objects was made by the Burke Museum professional staff in consultation with....R50000] Notice of Inventory Completion: Thomas Burke Memorial Washington State Museum, University of... Memorial Washington State Museum, University of Washington (Burke Museum), has completed an inventory of...
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Federal Register 2010, 2011, 2012, 2013, 2014
2013-09-30
... DEPARTMENT OF THE INTERIOR National Park Service [NPS-WASO-NAGPRA-13881; PPWOCRADN0-PCU00RP14.R50000] Notice of Inventory Completion: Thomas Burke Memorial Washington State Museum, University of.... SUMMARY: The Thomas Burke Memorial Washington State Museum, University of Washington (Burke Museum), has...
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Federal Register 2010, 2011, 2012, 2013, 2014
2013-09-30
.... Consultation A detailed assessment of the human remains was made by the Burke Museum professional staff in....R50000] Notice of Inventory Completion: Thomas Burke Memorial Washington State Museum, University of... Memorial Washington State Museum, University of Washington (Burke Museum), has completed an inventory of...
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History of Cardiothoracic Surgery at Washington University in Saint Louis.
Moon, Marc R
2016-01-01
The Division of Cardiothoracic Surgery at Washington University evolved a century ago to address what many considered to be the last surgical frontier, diseases of the chest. In addition, as one of the first training programs in thoracic surgery, Washington University has been responsible for educating more thoracic surgeons than nearly any other program in the world. Beginning with Evarts A. Graham and continuing through to Ralph J. Damiano Jr., the leaders of the division have had a profound impact on the field of cardiothoracic surgery. Copyright © 2016 Elsevier Inc. All rights reserved.
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Federal Register 2010, 2011, 2012, 2013, 2014
2013-10-25
... inventory of human remains under the control of the Burke Museum. The human remains were removed from Island....R50000] Notice of Inventory Completion: Thomas Burke Memorial Washington State Museum, University of... Memorial Washington State Museum, University of Washington (Burke Museum), has completed an inventory of...
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MIGRATION OF COLLEGE AND UNIVERSITY STUDENTS, STATE OF WASHINGTON.
ERIC Educational Resources Information Center
GOSSMAN, CHARLES S.; AND OTHERS
TWO GENERAL ASPECTS OF COLLEGE AND UNIVERSITY STUDENT MIGRATION AS IT RELATES TO THE STATE OF WASHINGTON ARE DISCUSSED. THE FIRST ASPECT INCLUDES ANALYSIS OF MIGRATION PATTERNS IN ACCORDANCE WITH ENROLLMENT CATEGORIES AND TYPES OF INSTITUTIONS, DIFFERENTIAL VOLUMES AND PATTERNS OF MIGRATION FOR SPECIFIC COLLEGES AND UNIVERSITIES IN THE STATE, AND…
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Federal Register 2010, 2011, 2012, 2013, 2014
2011-11-29
...: Washington State University, Museum of Anthropology, Pullman, WA AGENCY: National Park Service, Interior. ACTION: Notice. SUMMARY: The Washington State University, Museum of Anthropology (WSU) has completed an... University, Museum of Anthropology, Pullman, WA 99164-4910, telephone (509) 335-4314. SUPPLEMENTARY...
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ERIC Educational Resources Information Center
Officer, Starla D. H.; Bringle, Robert G.; Grim, Jim
2011-01-01
Indiana University-Purdue University Indianapolis worked with the residents and leadership of three neighborhoods adjacent to the campus to reopen the closed George Washington High School. The resulting partnership has strengthened the civic engagement mission of the university, and contributed to an award-winning community-based school. The…
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ERIC Educational Resources Information Center
Roselle, Ann; Chan, Karen
This collection development policy serves as a guide for the selection and retention of depository government documents by the Government Publications Unit of the Kennedy Memorial Library of Eastern Washington University (EWU) in Cheney, Washington. The library selects approximately 65 percent of the depository items distributed by the U.S.…
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Ai, Yuncan; Ai, Hannan; Meng, Fanmei; Zhao, Lei
2013-01-01
No attention has been paid on comparing a set of genome sequences crossing genetic components and biological categories with far divergence over large size range. We define it as the systematic comparative genomics and aim to develop the methodology. First, we create a method, GenomeFingerprinter, to unambiguously produce a set of three-dimensional coordinates from a sequence, followed by one three-dimensional plot and six two-dimensional trajectory projections, to illustrate the genome fingerprint of a given genome sequence. Second, we develop a set of concepts and tools, and thereby establish a method called the universal genome fingerprint analysis (UGFA). Particularly, we define the total genetic component configuration (TGCC) (including chromosome, plasmid, and phage) for describing a strain as a systematic unit, the universal genome fingerprint map (UGFM) of TGCC for differentiating strains as a universal system, and the systematic comparative genomics (SCG) for comparing a set of genomes crossing genetic components and biological categories. Third, we construct a method of quantitative analysis to compare two genomes by using the outcome dataset of genome fingerprint analysis. Specifically, we define the geometric center and its geometric mean for a given genome fingerprint map, followed by the Euclidean distance, the differentiate rate, and the weighted differentiate rate to quantitatively describe the difference between two genomes of comparison. Moreover, we demonstrate the applications through case studies on various genome sequences, giving tremendous insights into the critical issues in microbial genomics and taxonomy. We have created a method, GenomeFingerprinter, for rapidly computing, geometrically visualizing, intuitively comparing a set of genomes at genome fingerprint level, and hence established a method called the universal genome fingerprint analysis, as well as developed a method of quantitative analysis of the outcome dataset. These have set
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Federal Register 2010, 2011, 2012, 2013, 2014
2013-01-11
... Inventory Completion: The Museum of Anthropology at Washington State University, Pullman, WA AGENCY: National Park Service, Interior. ACTION: Notice. SUMMARY: The Museum of Anthropology has completed an... contact the Museum of Anthropology at Washington State University. Repatriation of the human remains...
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Federal Register 2010, 2011, 2012, 2013, 2014
2011-11-29
... Cultural Items: Washington State University, Museum of Anthropology, Pullman, WA AGENCY: National Park Service, Interior. ACTION: Notice. SUMMARY: The Washington State University, Museum of Anthropology (WSU... Anthropology, Pullman, WA 99164-4910, telephone (509) 335-4314. SUPPLEMENTARY INFORMATION: Notice is here given...
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Federal Register 2010, 2011, 2012, 2013, 2014
2013-03-29
...-PPWOCRADN0] Notice of Inventory Completion: University of Washington, Department of Anthropology, Seattle, WA..., Department of Anthropology, has completed an inventory of human remains and associated funerary objects, in... Burke Museum acting on behalf of the University of Washington, Department of Anthropology. Disposition...
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Federal Register 2010, 2011, 2012, 2013, 2014
2013-01-11
... Inventory Completion: The Museum of Anthropology at Washington State University, Pullman, WA AGENCY: National Park Service, Interior. ACTION: Notice. SUMMARY: The Museum of Anthropology has completed an... objects may contact the Museum of Anthropology at Washington State University. Repatriation of the human...
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Federal Register 2010, 2011, 2012, 2013, 2014
2013-05-01
....R50000] Notice of Inventory Completion: University of Washington, Department of Anthropology, Seattle, WA..., Department of Anthropology, has completed an inventory of human remains and associated funerary objects, in... Burke Museum acting on behalf of the University of Washington, Department of Anthropology. Disposition...
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Federal Register 2010, 2011, 2012, 2013, 2014
2013-01-24
... Inventory Completion: University of Washington, Department of Anthropology, Seattle, WA AGENCY: National... Anthropology, has completed an inventory of human remains and associated funerary objects, in consultation with... acting on behalf of the University of Washington, Department of Anthropology. Disposition of the human...
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Federal Register 2010, 2011, 2012, 2013, 2014
2012-12-18
... Inventory Completion: The Museum of Anthropology at Washington State University, Pullman, WA AGENCY: National Park Service, Interior. ACTION: Notice. SUMMARY: The Museum of Anthropology has completed an... objects may contact the Museum of Anthropology at Washington State University. Repatriation of the human...
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Federal Register 2010, 2011, 2012, 2013, 2014
2013-04-15
....R50000] Notice of Inventory Completion: University of Washington, Department of Anthropology, Seattle, WA..., Department of Anthropology, has completed an inventory of human remains, in consultation with the appropriate... acting on behalf of the University of Washington, Department of Anthropology. If no additional requestors...
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Federal Register 2010, 2011, 2012, 2013, 2014
2010-06-28
... DEPARTMENT OF THE INTERIOR National Park Service Notice of Inventory Completion: Thomas Burke Memorial Washington State Museum, University of Washington, Seattle, WA; Correction AGENCY: National Park... human remains and associated funerary objects in the possession of the Thomas Burke Memorial Washington...
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Composition at Washington State University: Building a Multimodal Bricolage
ERIC Educational Resources Information Center
Ericsson, Patricia; Hunter, Leeann Downing; Macklin, Tialitha Michelle; Edwards, Elizabeth Sue
2016-01-01
Multimodal pedagogy is increasingly accepted among composition scholars. However, putting such pedagogy into practice presents significant challenges. In this profile of Washington State University's first-year composition program, we suggest a multi-vocal and multi-theoretical approach to addressing the challenges of multimodal pedagogy. Patricia…
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Federal Register 2010, 2011, 2012, 2013, 2014
2010-03-25
... assessment of the human remains was made by Burke Museum and Central Washington University professional staff... Burke Museum staff legally transferred elements associated with the individual to Central Washington... Burke Museum later that same year (Burke Accn. 2056). In 1974, the Burke Museum staff legally...
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Federal Register 2010, 2011, 2012, 2013, 2014
2013-12-26
....R50000] Notice of Inventory Completion: Museum of Anthropology at Washington State University, Pullman, WA AGENCY: National Park Service, Interior. ACTION: Notice. SUMMARY: The Museum of Anthropology at... the Museum of Anthropology at Washington State University. If no additional requestors come forward...
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ERIC Educational Resources Information Center
Jonsen, Albert R.
1989-01-01
The development of medical ethics education at the University of California, San Francisco, is chronicled and its contributions to bioethics literature are noted. Emphasis is placed on the importance of using medical cases in such instruction. The University of Washington's ethics program and its potential for innovation are then described.…
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The University of Washington Mobile Planetarium: A Do-it-yourself Guide
NASA Astrophysics Data System (ADS)
Rosenfield, P.; Gaily, J.; Fraser, O.; Wisniewski, J.
2014-07-01
The University of Washington mobile planetarium project is a student-driven effort to bring astronomy to secondary schools, and the community, in Seattle, USA. This paper presents the solution that was designed and built in order to use the World- Wide Telescope — a computer program created by Microsoft that displays the astronomical sky as maps, the 3D Universe, and earth science data — from a laptop and an off-the-shelf high-definition (HD) projector located in an inflatable plane- tarium. In the first six months of operation, undergraduates at the University of Washington presented planetarium shows to over 1500 people, and 150 secondary school students created and presented their own astronomy projects in our dome, at their school. This paper aims to share the technical aspects of the project so that others can replicate the model or adapt it to their needs. This project was made possible thanks to a NASA/ESA Hubble Space Telescope education/public outreach grant.
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UNIVERSITY OF WASHINGTON ELECTROSTATIC SCRUBBER TESTS AT A STEEL PLANT
The report gives results of a demonstration of the effectiveness of a 1700 cu m/hr (1000 acfm) University of Washington (UW) Electrostatic Spray Scrubber in controlling fine particle emissions from an electric-arc steel furnace. The two-stage portable pilot plant operates by comb...
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Commitments: A Guide to Community Involvement Programs at The George Washington University.
ERIC Educational Resources Information Center
George Washington Univ., Washington, DC.
This guide to community involvement programs sponsored by the George Washington University provides a synopsis and a contact person for 33 general university programs, 38 medical school and hospital programs, eight National Law Center programs, eight School of Engineering and Applied Science programs, and two programs of the Division of…
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Federal Register 2010, 2011, 2012, 2013, 2014
2013-01-24
... Inventory Completion: University of Washington, Department of Anthropology, Seattle, WA AGENCY: National... Anthropology, has completed an inventory of human remains and associated funerary objects, in consultation with... of Washington, Department of Anthropology. Disposition of the human remains to the Indian tribes...
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Development of a Maximum Admissions Index for Freshman Admissions to the University of Washington.
ERIC Educational Resources Information Center
Lunneborg, Clifford E.
A new technique has been developed for admitting new freshman students at the University of Washington. Previously, an Admissions Index (AI) was used, in which the high school grade point average (HSGPA) was assigned twice the weight of the composite verbal and quantitative scores from the Washington Pre-College Test Battery (WPC). To offset the…
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Federal Register 2010, 2011, 2012, 2013, 2014
2013-03-29
...-PPWOCRADN0] Notice of Inventory Completion: University of Washington, Department of Anthropology, Seattle, WA..., Department of Anthropology, has completed an inventory of human remains, in consultation with the appropriate... Washington, Department of Anthropology. Disposition of the human remains to the Indian tribes stated below...
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Federal Register 2010, 2011, 2012, 2013, 2014
2013-02-19
... A detailed assessment of the human remains was made by the Burke Museum professional staff in... Inventory Completion: Thomas Burke Memorial Washington State Museum, University of Washington, Seattle, WA... State Museum (Burke Museum) has completed an inventory of human remains, in consultation with the...
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Federal Register 2010, 2011, 2012, 2013, 2014
2012-08-02
... Museum professional staff in consultation with representatives of the Coeur D'Alene Tribe of the Coeur D... Inventory Completion: Thomas Burke Memorial Washington State Museum, University of Washington, Seattle, WA... State Museum (Burke Museum) has completed an inventory of human remains and associated funerary objects...
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Austin, Melissa A
2002-04-01
Recent completion of the draft sequence of the human genome has been greeted with both excitement and skepticism, and the potential of this accomplishment for advancing public health has been tempered by ethical concerns about the protection of human subjects. This commentary explores ethical issues arising in human genome epidemiology by using a case study approach based on the ongoing Japanese American Family Study at the University of Washington in Seattle (1994-2003). Ethical issues encountered in designing the study, collecting the data, and reporting the study results are considered. When developing studies, investigators must consider whether to restrict the study to specific racial or ethnic groups and whether community involvement is appropriate. Once the study design is in place, further ethical issues emerge, including obtaining informed consent for DNA banking and protecting the privacy and confidentiality of family members. Finally, investigators must carefully consider whether to report genotype results to study participants and whether pedigrees illustrating the results of the study will be published. Overall, the promise of genomics for improving public health must be pursued based on the fundamental ethical principles of respect for persons, beneficence, and justice.
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Washington State University Algae Biofuels Research
DOE Office of Scientific and Technical Information (OSTI.GOV)
chen, Shulin; McCormick, Margaret; Sutterlin, Rusty
The goal of this project was to advance algal technologies for the production of biofuels and biochemicals by establishing the Washington State Algae Alliance, a collaboration partnership among two private companies (Targeted Growth, Inc. (TGI), Inventure Chemicals (Inventure) Inc (now Inventure Renewables Inc) and Washington State University (WSU). This project included three major components. The first one was strain development at TGI by genetically engineering cyanobacteria to yield high levels of lipid and other specialty chemicals. The second component was developing an algal culture system at WSU to produce algal biomass as biofuel feedstock year-round in the northern states ofmore » the United States. This system included two cultivation modes, the first one was a phototrophic process and the second a heterotrophic process. The phototrophic process would be used for algae production in open ponds during warm seasons; the heterotrophic process would be used in cold seasons so that year-round production of algal lipid would be possible. In warm seasons the heterotrophic process would also produce algal seeds to be used in the phototrophic culture process. Selected strains of green algae and cyanobacteria developed by TGI were tested in the system. The third component was downstream algal biomass processing by Inventure that included efficiently harvesting the usable fuel fractions from the algae mass and effectively isolating and separating the usable components into specific fractions, and converting isolated fractions into green chemicals.« less
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Towards the Perfect Genome Sequence (Opening Keynote) (7th Annual SFAF Meeting, 2012)
Weinstock, George
2018-04-30
George Weinstock, associate director at the Genome Institute at Washington University, delivered the opening keynote "Towards the Perfect Genome Sequence" at the 2012 Sequencing, Finishing, Analysis in the Future Meeting held June 5-7, 2012 in Santa Fe, New Mexico.
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Towards the Perfect Genome Sequence (Opening Keynote) (7th Annual SFAF Meeting, 2012)
DOE Office of Scientific and Technical Information (OSTI.GOV)
Weinstock, George
2012-06-01
George Weinstock, associate director at the Genome Institute at Washington University, delivered the opening keynote "Towards the Perfect Genome Sequence" at the 2012 Sequencing, Finishing, Analysis in the Future Meeting held June 5-7, 2012 in Santa Fe, New Mexico.
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Now It's Necessary: Virtual Reference Services at Washington State University, Pullman
ERIC Educational Resources Information Center
Nicol, Erica Carlson; Crook, Linda
2013-01-01
While virtual reference services (VRS) are becoming more and more common in academic libraries, implementing and maintaining well-used and effective VRS can be a challenge in the face of competing demands on time, staffing, and funding. Between 2011 and 2012, librarians at Washington State University, Pullman (WSU) have overhauled and reorganized…
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UNIVERSITY OF WASHINGTON ELECTROSTATIC SCRUBBER TESTS AT A COAL-FIRED POWER PLANT
The report gives results of tests of a 1700 cu m/hr University of Washington Electrostatic Spray Scrubber pilot plant on a coal-fired boiler to demonstrate its effectiveness for controlling fine particle emissions. The multiple-pass, portable pilot plant combines oppositely charg...
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ERIC Educational Resources Information Center
Quigley, Martin S.
The founding and missions of Georgetown University and George Washington University, two early land-grant colleges, are considered. The account is based partially on standard histories of the colleges, and other information comes from Congressional Records. Some understanding of why Congress took an interest in the founding and survival of…
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Federal Register 2010, 2011, 2012, 2013, 2014
2012-08-24
... Anthropology and the Burke Museum professional staff in consultation with representatives of Catawba Indian... culturally affiliated with the human remains may contact the Burke Museum acting on behalf of the University..., Burke Museum, University of Washington, Box 353010, Seattle, WA 98195, telephone (206) 685-3849...
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Minie, Mark; Bowers, Stuart; Tarczy-Hornoch, Peter; Roberts, Edward; James, Rose A.; Rambo, Neil; Fuller, Sherrilynne
2006-01-01
Setting: The University of Washington Health Sciences Libraries and Information Center BioCommons serves the bioinformatics needs of researchers at the university and in the vibrant for-profit and not-for-profit biomedical research sector in the Washington area and region. Program Components: The BioCommons comprises services addressing internal University of Washington, not-for-profit, for-profit, and regional and global clientele. The BioCommons is maintained and administered by the BioResearcher Liaison Team. The BioCommons architecture provides a highly flexible structure for adapting to rapidly changing resources and needs. Evaluation Mechanisms: BioCommons uses Web-based pre- and post-course evaluations and periodic user surveys to assess service effectiveness. Recent surveys indicate substantial usage of BioCommons services and a high level of effectiveness and user satisfaction. Next Steps/Future Directions: BioCommons is developing novel collaborative Web resources to distribute bioinformatics tools and is experimenting with Web-based competency training in bioinformation resource use. PMID:16888667
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Case Study III: The University of Washington and Bellevue School District Partnership
ERIC Educational Resources Information Center
Coburn, Cynthia E.; Penuel, William R.; Geil, Kimberly E.
2015-01-01
This design-research partnership involves learning scientists, design researchers, and graduate students from the Learning in Informal and Formal Environments (LIFE) Center and the College of Education at the University of Washington (UW), and district staff, teachers, and students from the Bellevue School District (BSD). The goal of their work is…
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Federal Register 2010, 2011, 2012, 2013, 2014
2010-06-28
... University (the licensee, WSU) to operate the Washington State University Modified TRIGA Nuclear Radiation... NUCLEAR REGULATORY COMMISSION [Docket No. 50-27; Facility Operating License No. R-76; NRC-2010... Safeguards Information and Sensitive Unclassified Non-Safeguards Information AGENCY: Nuclear Regulatory...
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Mobility of Undergraduate College Students Between Washington Colleges and Universities, Fall 1971.
ERIC Educational Resources Information Center
Winchester, E. Anne; Kenny, Eleanore
This study investigated the mobility of undergraduate college students between Washington colleges and universities fall, 1971. Data were taken from Table 1 of the Higher Education Enrollment Projection (HEEP) model report forms. HEEP data reports transfers on a fall to fall basis whereas this study has recorded transfers on a spring to fall…
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Advancing Mental Health Research: Washington University's Center for Mental Health Services Research
ERIC Educational Resources Information Center
Proctor, Enola K.; McMillen, Curtis; Haywood, Sally; Dore, Peter
2008-01-01
Research centers have become a key component of the research infrastructure in schools of social work, including the George Warren Brown School of Social Work at Washington University. In 1993, that school's Center for Mental Health Services Research (CMHSR) received funding from the National Institute of Mental Health (NIMH) as a Social Work…
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Sociology at Washington University in St. Louis: History and Reflections, 1906-1989.
ERIC Educational Resources Information Center
Pittman, David J.; Boden, Deirdre
1990-01-01
Traces the history of sociology at Washington University (Missouri) from 1906 to 1989 in relation to the decision to abolish the department. Maintains that this decision began in 1968. Defines the contours of the sociology department, including a discussion of prominent scholars, contending that the decision will harm the discipline in the long…
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ERIC Educational Resources Information Center
Blume, Grant; Roza, Marguerite
2012-01-01
This case study examines admissions data at the University of Washington (UW) in order to quantify the effect on admissions standards for residents versus nonresidents. Like many other state flagship universities, the UW has suffered from constrained state revenues during the recent recessionary years. The findings suggest that Washington…
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Interprofessional Initiatives at the University of Washington
Robins, Lynne; Murphy, Nanci; Belza, Basia; Brock, Doug; Gallagher, Thomas H.; Lindhorst, Taryn; Morton, Tom; Schaad, Doug; Mitchell, Pamela
2009-01-01
Pharmacists must collaborate with other health professionals to promote the optimal use of medications, relying on coordinated, interprofessional communication and care to do so. In 2003, the Institute of Medicine (IOM) recommended “all health professionals should be educated to deliver patient-centered care as members of an interdisciplinary team, emphasizing evidence-based practice, quality improvement approaches, and informatics.”2 At the University of Washington, the Center for Health Sciences Interprofessional Education (CHSIE) was established in 1997 to promote interprofessional curricular and clinical innovation in education, faculty development, and student activities, and to conduct evaluative research regarding the impact of interprofessional innovations. In this manuscript, we will describe the Center for Health Sciences Interprofessional Education, and highlight key projects that serve as examples of pharmacy involvement in interprofessional education, research, and service. PMID:19657496
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Development of the University of Washington Biofuels and Biobased Chemicals Process Laboratory
DOE Office of Scientific and Technical Information (OSTI.GOV)
Gustafson, Richard
2014-02-04
The funding from this research grant enabled us to design and build a bioconversion steam explosion reactor and ancillary equipment such as a high pressure boiler and a fermenter to support the bioconversion process research. This equipment has been in constant use since its installation in 2012. Following are research projects that it has supported: • Investigation of novel chip production method in biofuels production • Investigation of biomass refining following steam explosion • Several studies on use of different biomass feedstocks • Investigation of biomass moisture content on pretreatment efficacy. • Development of novel instruments for biorefinery process controlmore » Having this equipment was also instrumental in the University of Washington receiving a $40 million grant from the US Department of Agriculture for biofuels development as well as several other smaller grants. The research that is being done with the equipment from this grant will facilitate the establishment of a biofuels industry in the Pacific Northwest and enable the University of Washington to launch a substantial biofuels and bio-based product research program.« less
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DOE Office of Scientific and Technical Information (OSTI.GOV)
Clark, Sue B.; Nash, Ken; Benny, Paul
2009-08-19
Since 2002, Washington State University has been building radiochemistry as a component of its overall chemistry program. Using an aggressive hiring strategy and leveraged funds from the state of Washington and federal agencies, six radiochemistry faculty members have been added to give a total of seven radiochemists out of a department of twenty-five faculty members. These faculty members contribute to a diverse curriculum in radiochemistry, and the Chemistry Department now enjoys a significant increase in the number of trainees, the quantity of research expenditures, and the volume and quality of peer-reviewed scientific literature generated by the radiochemistry faculty and themore » trainees. These three factors are essential for sustaining the radiochemistry education and research program at any academic institution.« less
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A Passion for Learning: The Theory and Practice of Optimal Match at the University of Washington
ERIC Educational Resources Information Center
Noble, Kathleen D.; Childers, Sarah A.
2008-01-01
Early entrance from secondary school to university, based on the principle of optimal match, is a rare but highly effective educational strategy for many gifted students. The University of Washington offers two early entrance options for gifted adolescents: the Early Entrance Program for students prior to age 15, and the UW Academy for Young…
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Innovations in Ocean Sciences Education at the University of Washington
NASA Astrophysics Data System (ADS)
Robigou, V.
2003-12-01
A new wave of education collaborations began when the national science education reform documents (AAAS Project 2061 and National Science Education Standards) recommended that scientific researchers become engaged stakeholders in science education. Collaborations between research institutions, universities, nonprofits, corporations, parent groups, and school districts can provide scientists original avenues to contribute to education for all. The University of Washington strongly responded to the national call by promoting partnerships between the university research community, the K-12 community and the general public. The College of Ocean and Fishery Sciences and the School of Oceanography spearheaded the creation of several innovative programs in ocean sciences to contribute to the improvement of Earth science education. Two of these programs are the REVEL Project and the Marine Science Student Mobility (MSSM) program that share the philosophy of involving school districts, K-12 science teachers, their students and undergraduate students in current, international, cutting-edge oceanographic research. The REVEL Project (Research and Education: Volcanoes, Exploration and Life) is an NSF-funded, professional development program for middle and high school science teachers that are determined to use deep-sea research and seafloor exploration as tools to implement inquiry-based science in their classrooms, schools, and districts, and to share their experiences with their communities. Initiated in 1996 as a regional program for Northwest science educators, REVEL evolved into a multi-institutional program inviting teachers to practice doing research on sea-going research expeditions. Today, in its 7th year, the project offers teachers throughout the U. S. an opportunity to participate and contribute to international, multidisciplinary, deep-sea research in the Northeast Pacific ocean to study the relationship between geological processes such as earthquakes and
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A DIY Campus Preservation Plan: Lessons Learned at the University of Mary Washington
ERIC Educational Resources Information Center
Smith, Andrea Livi; Spencer, Michael
2012-01-01
The University of Mary Washington (UMW) in Fredericksburg, Virginia, was founded in 1908. This article describes the process that led to the UMW preservation plan. Unlike most preservation plans, the UMW plan was developed in-house with limited funds. Furthermore, the catalyst for the plan was a grassroots effort on the part of students and alumni…
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Improvement of Oncology Education at the University of Washington School of Medicine, 1984-1988.
ERIC Educational Resources Information Center
Bleyer, W. Archie; And Others
1990-01-01
After development and implementation of a revised oncology curriculum at the University of Washington School of Medicine student performance on oncology related questions on the National Board of Medical Examiners examination indicated substantial improvement relative to student performance in non-oncology areas and to the national average. (DB)
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ERIC Educational Resources Information Center
Soper, Mary Ellen
1987-01-01
This discussion of the inclusion of descriptive cataloging as part of library education describes the descriptive cataloging segment of the curriculum at the University of Washington, including the sequence of courses and the content and objectives of each course. (CLB)
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ERIC Educational Resources Information Center
Beaufond-Marcano, Rafael Emilio
Financial patterns at American University, Catholic University, George Washington University, and Georgetown University were investigated. Specific areas of concern include: revenue sources and expenditures, balance sheet formats, financial health, the effect of external factors such as enrollment and inflation, financial performance, ability to…
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Federal Register 2010, 2011, 2012, 2013, 2014
2013-02-19
... Inventory Completion: University of Washington, Department of Anthropology, Seattle, WA AGENCY: National... Anthropology, has completed an inventory of human remains and associated funerary objects, in consultation with... Anthropology. Disposition of the human remains and associated funerary objects to the Indian tribes stated...
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Federal Register 2010, 2011, 2012, 2013, 2014
2013-09-30
... Accn. 3183). In 1974, the Burke Museum staff legally transferred elements associated with the... 1939 (Burke Accn. 3101). In 1974, the Burke Museum staff legally transferred elements associated with....R50000] Notice of Inventory Completion: Thomas Burke Memorial Washington State Museum, University of...
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ERIC Educational Resources Information Center
Hertzog, Nancy B.; Chung, Rachel U.
2015-01-01
Radical acceleration from middle school to university is an unusual option in the United States. The Early Entrance Program and the University of Washington (UW) Academy for Young Scholars housed in the Halbert and Nancy Robinson Center for Young Scholars are two of only 21 early university entrance programs offered in the United States. Due to…
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Federal Register 2010, 2011, 2012, 2013, 2014
2013-01-24
... Inventory Completion: University of Washington, Department of Anthropology, Seattle, WA AGENCY: National... Anthropology, has completed an inventory of human remains, in consultation with the appropriate Indian tribes..., Department of Anthropology. Disposition of the human remains to the Indian tribes stated below may occur if...
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Next Generation Sequencing at the University of Chicago Genomics Core
DOE Office of Scientific and Technical Information (OSTI.GOV)
Faber, Pieter
2013-04-24
The University of Chicago Genomics Core provides University of Chicago investigators (and external clients) access to State-of-the-Art genomics capabilities: next generation sequencing, Sanger sequencing / genotyping and micro-arrays (gene expression, genotyping, and methylation). The current presentation will highlight our capabilities in the area of ultra-high throughput sequencing analysis.
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Washington State Biofuels Industry Development
DOE Office of Scientific and Technical Information (OSTI.GOV)
Gustafson, Richard
2017-04-09
The funding from this research grant enabled us to design, renovate, and equip laboratories to support University of Washington biofuels research program. The research that is being done with the equipment from this grant will facilitate the establishment of a biofuels industry in the Pacific Northwest and enable the University of Washington to launch a substantial biofuels and bio-based product research program.
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ERIC Educational Resources Information Center
McManus, Dean A.
2002-01-01
Reports on the development of a program preparing graduate students to teach in the School of Oceanography, University of Washington, in response to repeated graduate student complaints about the lack of a program. Describes the program which is based on surveys of groups affected by the program and research on teaching assistant preparation,…
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Federal Register 2010, 2011, 2012, 2013, 2014
2011-05-18
... Museum), University of Washington, has completed an inventory of human remains and associated funerary... affiliation between the human remains and associated funerary objects and a present-day Indian tribe. Representatives of any Indian tribe that believes itself to be culturally affiliated with the human remains and...
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Transforming a Curriculum Center for the 21st Century at Eastern Washington University Libraries
ERIC Educational Resources Information Center
Miller, Julie; Meyer, Nadean
2008-01-01
Teacher education is a vital component of Eastern Washington University's (EWU) mission and history. In 2006, after several years of decline in collections and usage of its curriculum center, EWU Libraries made a commitment to transform it into a center for twenty-first century educators. The center has changed greatly in a short time with five…
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ERIC Educational Resources Information Center
Tom, Alan R.
1988-01-01
This article proposes rules of thumb about the teacher education design process. The rules are grounded in the attempts at reforming teacher education at Washington University in the early 1970s, at a time during which a year-long, field-based alternative to the traditional elementary program was operated. (IAH)
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Federal Register 2010, 2011, 2012, 2013, 2014
2013-08-19
... . SUPPLEMENTARY INFORMATION: Notice is here given in accordance with the Native American Graves Protection and... removed from the Dunlap/Sedro Wooley High School Site (45-SK-35) on the Skagit River delta in Skagit County, WA. The human remains were removed during a University of Washington Field School Expedition led...
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ERIC Educational Resources Information Center
Zeretzke, Dale
This report presents results of a survey of 354 Economic and Medical Field Services (EMFS) division social workers in Washington State. The survey investigated their needs for graduate level academic credit from professional training provided by Western Washington University (WWU), as well as matters of credit utility and institutional and…
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Carson, H L
2001-04-01
In the early 1940s, the administration of the College of Arts and Sciences at Washington University, St. Louis was firmly in the hands of classical scholars who were not inclined to promote the development of modern research on scientific subjects. Funds supporting research in biology favored the School of Medicine and the Missouri Botanical Garden. Viktor Hamburger arrived at Washington University in 1935. At about the time he became the Acting Chairman of Zoology in 1942, research work in the biological departments began a dramatic surge that has continued to this day. For 65 years under his counsel and leadership, basic biology has thrived at this fine institution. As an early faculty recruit, I recount here a few personal recollections from those formative years.
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The Installation of a P.E.T. Pharmacy at Washington University
NASA Astrophysics Data System (ADS)
Gaehle, G.; Schwarz, S.; Mueller, M.; Margenau, B.; Welch, M. J.
2003-08-01
Washington University has produced radioisotopes for medical application since the early 1960s. In order to serve seven PET scanners and to meet more stringent government regulations we have installed a new PET pharmacy based on our past years of experiences. The new pharmacy was installed at the site of the 3.7 MeV tandem cascade accelerator that was decommissioned in April of 2001. The pharmacy consists of a production lab, quality control lab, reagent preparation lab, shipping and storage area and an office. Security and safety was a main consideration in the design of this PET pharmacy.
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The Installation of a P.E.T. Pharmacy at Washington University
DOE Office of Scientific and Technical Information (OSTI.GOV)
Gaehle, G.; Schwarz, S.; Mueller, M.
2003-08-26
Washington University has produced radioisotopes for medical application since the early 1960s. In order to serve seven PET scanners and to meet more stringent government regulations we have installed a new PET pharmacy based on our past years of experiences. The new pharmacy was installed at the site of the 3.7 MeV tandem cascade accelerator that was decommissioned in April of 2001. The pharmacy consists of a production lab, quality control lab, reagent preparation lab, shipping and storage area and an office. Security and safety was a main consideration in the design of this PET pharmacy.
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The Pediatric Cancer Genome Project
Downing, James R; Wilson, Richard K; Zhang, Jinghui; Mardis, Elaine R; Pui, Ching-Hon; Ding, Li; Ley, Timothy J; Evans, William E
2013-01-01
The St. Jude Children’s Research Hospital–Washington University Pediatric Cancer Genome Project (PCGP) is participating in the international effort to identify somatic mutations that drive cancer. These cancer genome sequencing efforts will not only yield an unparalleled view of the altered signaling pathways in cancer but should also identify new targets against which novel therapeutics can be developed. Although these projects are still deep in the phase of generating primary DNA sequence data, important results are emerging and valuable community resources are being generated that should catalyze future cancer research. We describe here the rationale for conducting the PCGP, present some of the early results of this project and discuss the major lessons learned and how these will affect the application of genomic sequencing in the clinic. PMID:22641210
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House, Peter J; Hartfield, Karen; Nicola, Bud; Bogan, Sharon L
2014-01-01
The Community-Oriented Public Health Practice (COPHP) program, a 2-year in-residence MPH degree program in the University of Washington School of Public Health, has partnered with Public Health-Seattle & King County (PHSKC) since 2002 to create a mutually beneficial set of programs to improve teaching and address community-based public health problems in a practice setting. The COPHP program uses a problem-based learning approach that puts students in small groups to work on public health problems. Both University of Washington-based and PHSKC-based faculty facilitate the classroom work. In the first year for students, COPHP, in concert with PHSKC, places students in practicum assignments at PHSKC; in the second year, students undertake a master's project (capstone) in a community or public health agency. The capstone project entails taking on a problem in a community-based agency to improve either the health of a population or the capacity of the agency to improve population health. Both the practicum and the capstone projects emphasize applying classroom learning in actual public health practice work for community-based organizations. This partnership brings PHSKC and COPHP together in every aspect of teaching. In essence, PHSKC acts as the "academic health department" for COPHP. There are detailed agreements and contracts that guide all aspects of the partnership. Both the practicum and capstone projects require written contracts. The arrangements for getting non-University of Washington faculty paid for teaching and advising also include formal contracts.
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Epithermal neutron beam for BNCT research at Washington State University
DOE Office of Scientific and Technical Information (OSTI.GOV)
Venhuizen, J.R.; Nigg, D.W.; Wheeler, F.J.
1999-09-01
Veterinary radiation oncology researchers at the Washington State University (WSU) School of Veterinary Medicine have made major contributions to the understanding of the in-vivo radiobiology of boron neutron capture therapy (BNCT) over the years. Recent attention has been focused on the development of a more convenient and cost-effective local epithermal-neutron beam facility for BNCT research and boronated pharmaceutical screening in large-animal models at WSU. The design of such a facility, to be installed in the thermal column region of the TRIGA research reactor at WSU, was performed in a collaborative effort of SWU and the Idaho National Engineering and Environmentalmore » Laboratory. Construction is now underway.« less
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Requirements for a Washington State freight simulation model.
DOT National Transportation Integrated Search
2009-12-01
WSDOT and TransNow have already allocated $190,000 to researchers at the University of Washington and the : Washington State University to explore the flow of goods through the transportation system, the dynamics of that flow in : response to disrupt...
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ERIC Educational Resources Information Center
Zinchuk, Jennifer Eidum
2017-01-01
Within the field of Writing Studies, metacognition is rapidly being recognized as essential for the effective transfer of knowledge across contexts. This program profile describes a pre-college writing course at the University of Washington that builds metacognition, confidence, and fluency in writing. Through program evaluations, student surveys,…
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Federal Register 2010, 2011, 2012, 2013, 2014
2011-05-13
... DEPARTMENT OF THE INTERIOR National Park Service [2253-665] Notice of Inventory Completion: Museum... funerary items in the possession and control of the Museum of Anthropology at Washington State University..., 25 U.S.C. 3003(d)(3). The determinations in this notice are the sole responsibility of the museum...
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The Washington University Central Neuroimaging Data Archive
Gurney, Jenny; Olsen, Timothy; Flavin, John; Ramaratnam, Mohana; Archie, Kevin; Ransford, James; Herrick, Rick; Wallace, Lauren; Cline, Jeanette; Horton, Will; Marcus, Daniel S
2016-01-01
Since the early 2000’s, much of the neuroimaging work at Washington University (WU) has been facilitated by the Central Neuroimaging Data Archive (CNDA), an XNAT-based imaging informatics system. The CNDA is uniquely related to XNAT, as it served as the original codebase for the XNAT open source platform. The CNDA hosts data acquired in over 1000 research studies, encompassing 36,000 subjects and more than 60,000 imaging sessions. Most imaging modalities used in modern human research are represented in the CNDA, including magnetic resonance (MR), positron emission tomography (PET), computed tomography (CT), nuclear medicine (NM), computed radiography (CR), digital radiography (DX), and ultrasound (US). However, the majority of the imaging data in the CNDA are MR and PET of the human brain. Currently, about 20% of the total imaging data in the CNDA is available by request to external researchers. CNDA’s available data includes large sets of imaging sessions and in some cases clinical, psychometric, tissue, or genetic data acquired in the study of Alzheimer’s disease, brain metabolism, cancer, HIV, sickle cell anemia, and Tourette syndrome. PMID:26439514
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Uprobe: a genome-wide universal probe resource for comparative physical mapping in vertebrates.
Kellner, Wendy A; Sullivan, Robert T; Carlson, Brian H; Thomas, James W
2005-01-01
Interspecies comparisons are important for deciphering the functional content and evolution of genomes. The expansive array of >70 public vertebrate genomic bacterial artificial chromosome (BAC) libraries can provide a means of comparative mapping, sequencing, and functional analysis of targeted chromosomal segments that is independent and complementary to whole-genome sequencing. However, at the present time, no complementary resource exists for the efficient targeted physical mapping of the majority of these BAC libraries. Universal overgo-hybridization probes, designed from regions of sequenced genomes that are highly conserved between species, have been demonstrated to be an effective resource for the isolation of orthologous regions from multiple BAC libraries in parallel. Here we report the application of the universal probe design principal across entire genomes, and the subsequent creation of a complementary probe resource, Uprobe, for screening vertebrate BAC libraries. Uprobe currently consists of whole-genome sets of universal overgo-hybridization probes designed for screening mammalian or avian/reptilian libraries. Retrospective analysis, experimental validation of the probe design process on a panel of representative BAC libraries, and estimates of probe coverage across the genome indicate that the majority of all eutherian and avian/reptilian genes or regions of interest can be isolated using Uprobe. Future implementation of the universal probe design strategy will be used to create an expanded number of whole-genome probe sets that will encompass all vertebrate genomes.
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NASA Astrophysics Data System (ADS)
Teich, Albert H.
2014-03-01
Many scientists believe that current U.S. visa and immigration systems are out of sync with today's increasingly globalized science and technology. This talk will highlight specific proposals that would facilitate the recruitment of promising STEM students by U.S. universities and better enable international scientists and engineers to visit the United States for scientific conferences and research collaboration. Most of these proposals could be implemented without additional resources and without compromising U.S. security. The talk is based on the results of an 18 month study conducted at the George Washington University's Center for International Science & Technology Policy.
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ERIC Educational Resources Information Center
Allard, Scott
In March 1992, a team of Big Bend Community College (BBCC) faculty members traveled to Washington State University (WSU) to survey and interview former BBCC students enrolled at WSU. The purpose of the investigation was to assess the effectiveness of BBCC in preparing students for transfer to and continued success at the four-year college level,…
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ERIC Educational Resources Information Center
Hernandez, Nicolas, Jr.
1988-01-01
Traces the origin of ISAAC (Information System for Advanced Academic Computing) and the development of a languages and linguistics "room" at the University of Washington-Seattle. ISAAC, a free, valuable resource, consists of two databases and an electronic bulletin board spanning broad areas of pedagogical and research fields. (Author/CB)
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Universal and idiosyncratic characteristic lengths in bacterial genomes
NASA Astrophysics Data System (ADS)
Junier, Ivan; Frémont, Paul; Rivoire, Olivier
2018-05-01
In condensed matter physics, simplified descriptions are obtained by coarse-graining the features of a system at a certain characteristic length, defined as the typical length beyond which some properties are no longer correlated. From a physics standpoint, in vitro DNA has thus a characteristic length of 300 base pairs (bp), the Kuhn length of the molecule beyond which correlations in its orientations are typically lost. From a biology standpoint, in vivo DNA has a characteristic length of 1000 bp, the typical length of genes. Since bacteria live in very different physico-chemical conditions and since their genomes lack translational invariance, whether larger, universal characteristic lengths exist is a non-trivial question. Here, we examine this problem by leveraging the large number of fully sequenced genomes available in public databases. By analyzing GC content correlations and the evolutionary conservation of gene contexts (synteny) in hundreds of bacterial chromosomes, we conclude that a fundamental characteristic length around 10–20 kb can be defined. This characteristic length reflects elementary structures involved in the coordination of gene expression, which are present all along the genome of nearly all bacteria. Technically, reaching this conclusion required us to implement methods that are insensitive to the presence of large idiosyncratic genomic features, which may co-exist along these fundamental universal structures.
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ERIC Educational Resources Information Center
Haselkorn, Mark P.; Sauer, Geoffrey; Turns, Jennifer; Illman, Deborah L.; Tsutsui, Michio; Plumb, Carolyn; Williams, Tom; Kolko, Beth; Spyridakis, Jan
2003-01-01
Presents eight current projects involving faculty in the University of Washington's Department of Technical Communication that illustrate the broadening of the field. Notes these projects address: the cognitive processing of visual material; Web-based education; strategic management of information; communicating science and technology in the…
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Yang, Jun-Bo; Li, De-Zhu; Li, Hong-Tao
2014-09-01
Chloroplast genomes supply indispensable information that helps improve the phylogenetic resolution and even as organelle-scale barcodes. Next-generation sequencing technologies have helped promote sequencing of complete chloroplast genomes, but compared with the number of angiosperms, relatively few chloroplast genomes have been sequenced. There are two major reasons for the paucity of completely sequenced chloroplast genomes: (i) massive amounts of fresh leaves are needed for chloroplast sequencing and (ii) there are considerable gaps in the sequenced chloroplast genomes of many plants because of the difficulty of isolating high-quality chloroplast DNA, preventing complete chloroplast genomes from being assembled. To overcome these obstacles, all known angiosperm chloroplast genomes available to date were analysed, and then we designed nine universal primer pairs corresponding to the highly conserved regions. Using these primers, angiosperm whole chloroplast genomes can be amplified using long-range PCR and sequenced using next-generation sequencing methods. The primers showed high universality, which was tested using 24 species representing major clades of angiosperms. To validate the functionality of the primers, eight species representing major groups of angiosperms, that is, early-diverging angiosperms, magnoliids, monocots, Saxifragales, fabids, malvids and asterids, were sequenced and assembled their complete chloroplast genomes. In our trials, only 100 mg of fresh leaves was used. The results show that the universal primer set provided an easy, effective and feasible approach for sequencing whole chloroplast genomes in angiosperms. The designed universal primer pairs provide a possibility to accelerate genome-scale data acquisition and will therefore magnify the phylogenetic resolution and species identification in angiosperms. © 2014 John Wiley & Sons Ltd.
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Child, Mara J; Kiarie, James N; Allen, Suzanne M; Nduati, Ruth; Wasserheit, Judith N; Kibore, Minnie W; John-Stewart, Grace; Njiri, Francis J; O'Malley, Gabrielle; Kinuthia, Raphael; Norris, Tom E; Farquhar, Carey
2014-08-01
A major medical education need in Sub-Saharan Africa includes expanding clinical training opportunities to develop health professionals. Medical education expansion is a complicated process that requires significant investment of financial and human resources, but it can also provide opportunities for innovative approaches and partnerships. In 2010, the U.S. President's Emergency Plan for AIDS Relief launched the Medical Education Partnership Initiative to invest in medical education and health system strengthening in Africa. Building on a 30-year collaborative clinical and research training partnership, the University of Nairobi in Kenya developed a pilot regional medical education program modeled on the WWAMI (Washington, Wyoming, Alaska, Montana, and Idaho) medical education program at the University of Washington in the United States. The University of Nairobi adapted key elements of the WWAMI model to expand clinical training opportunities without requiring major capital construction of new buildings or campuses. The pilot program provides short-term clinical training opportunities for undergraduate students and recruits and trains clinical faculty at 14 decentralized training sites. The adaptation of a model from the Northwestern United States to address medical education needs in Kenya is a successful transfer of knowledge and practices that can be scaled up and replicated across Sub-Saharan Africa.
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Child, Mara J.; Kiarie, James N.; Allen, Suzanne M.; Nduati, Ruth; Wasserheit, Judith N.; Kibore, Minnie W.; John-Stewart, Grace; Njiri, Francis J.; O'Malley, Gabrielle; Kinuthia, Raphael; Norris, Tom E.; Farquhar, Carey
2014-01-01
A major medical education need in Sub-Saharan Africa includes expanding clinical training opportunities to develop health professionals. Medical education expansion is a complicated process that requires significant investment of financial and human resources, but it can also provide opportunities for innovative approaches and partnerships. In 2010, the U.S. President's Emergency Plan for AIDS Relief (PEPFAR) launched the Medical Education Partnership Initiative to invest in medical education and health system strengthening in Africa. Building on a 30-year collaborative clinical and research training partnership, the University of Nairobi in Kenya developed a pilot regional medical education program modeled on the WWAMI (Washington, Wyoming, Alaska, Montana, and Idaho) medical education program at the University of Washington in the United States. The University of Nairobi adapted key elements of the WWAMI model to expand clinical training opportunities without requiring major capital construction of new buildings or campuses. The pilot program provides short-term clinical training opportunities for undergraduate students and recruits and trains clinical faculty at 14 decentralized training sites. The adaptation of a model from the Northwestern United States to address medical education needs in Kenya is a successful transfer of knowledge and practices that can be scaled up and replicated across Sub-Saharan Africa. PMID:25072575
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Dunnebacke, T H
2001-04-01
Beginning from an undergraduate's perspective and continuing through graduate school, this student's experiences in the Department of Zoology at Washington University in St. Louis, Missouri was a time of many rewarding experiences. Now, on this occasion of his 100th birthday, I wish to express my appreciation to the Chairman, Dr. Viktor Hamburger, for his teachings, his encouragement, and his friendship that has lasted over the past 56 years.
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During World War 1, The American University in Washington D.C. was used by the U.S. Army as an experiment station for the development and testing of a variety of battlefield munitions including chemical weapons such as Mustard Gas, Phosgene, Ricin and Lewisite, among others. Afte...
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During World War 1, The American University in Washington D.C. was used by the U.S. Army as an experiment station for the development and testing of a variety of battlefield munitions including chemical weapons such as Mustard Gas, Phosgene, Ricin and Lewisite, among others. Afte...
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Zhou, Bin; Lin, Xudong; Wang, Wei; Halpin, Rebecca A.; Bera, Jayati; Stockwell, Timothy B.; Barr, Ian G.
2014-01-01
Although human influenza B virus (IBV) is a significant human pathogen, its great genetic diversity has limited our ability to universally amplify the entire genome for subsequent sequencing or vaccine production. The generation of sequence data via next-generation approaches and the rapid cloning of viral genes are critical for basic research, diagnostics, antiviral drugs, and vaccines to combat IBV. To overcome the difficulty of amplifying the diverse and ever-changing IBV genome, we developed and optimized techniques that amplify the complete segmented negative-sense RNA genome from any IBV strain in a single tube/well (IBV genomic amplification [IBV-GA]). Amplicons for >1,000 diverse IBV genomes from different sample types (e.g., clinical specimens) were generated and sequenced using this robust technology. These approaches are sensitive, robust, and sequence independent (i.e., universally amplify past, present, and future IBVs), which facilitates next-generation sequencing and advanced genomic diagnostics. Importantly, special terminal sequences engineered into the optimized IBV-GA2 products also enable ligation-free cloning to rapidly generate reverse-genetics plasmids, which can be used for the rescue of recombinant viruses and/or the creation of vaccine seed stock. PMID:24501036
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University of Washington Mobile Planetarium: Bringing HST Science to Seattle Public Schools
NASA Astrophysics Data System (ADS)
Gailey, Justin; Fraiser, O.; Rosenfield, P.; Byler, E.; Wisniewski, J. P.
2013-01-01
Digital planetariums are becoming mainstays of astronomy education as projection technology prices fall and planetarium software becomes more powerful and more freely available. In 2010, the University of Washington upgraded their star-ball projector to a digital system that is powered by Microsoft Research’s WorldWide Telescope. To increase the number of underserved elementary and high school students the UW Astronomy department reaches, we obtained an HST education and public outreach grant to create lesson content, offset transportation costs to visit the UW planetarium for Seattle Public School students, and purchase a mobile planetarium to bring to public schools. We present a pilot program to test and evaluate the efficacy of the mobile planetarium in a high school setting.
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Federal Register 2010, 2011, 2012, 2013, 2014
2011-03-15
...: Museum of Anthropology at Washington State University, Pullman, WA AGENCY: National Park Service... Museum of Anthropology at Washington State University, Pullman, WA, that meets the definition of..., a copper pendant was given to the Museum of Anthropology at Washington State University for intended...
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Kang, Robert; Nimmons, Grace Liu; Drennan, Ward; Longnion, Jeff; Ruffin, Chad; Nie, Kaibao; Won, Jong Ho; Worman, Tina; Yueh, Bevan; Rubinstein, Jay
2009-08-01
Assessment of cochlear implant outcomes centers around speech discrimination. Despite dramatic improvements in speech perception, music perception remains a challenge for most cochlear implant users. No standardized test exists to quantify music perception in a clinically practical manner. This study presents the University of Washington Clinical Assessment of Music Perception (CAMP) test as a reliable and valid music perception test for English-speaking, adult cochlear implant users. Forty-two cochlear implant subjects were recruited from the University of Washington Medical Center cochlear implant program and referred by two implant manufacturers. Ten normal-hearing volunteers were drawn from the University of Washington Medical Center and associated campuses. A computer-driven, self-administered test was developed to examine three specific aspects of music perception: pitch direction discrimination, melody recognition, and timbre recognition. The pitch subtest used an adaptive procedure to determine just-noticeable differences for complex tone pitch direction discrimination within the range of 1 to 12 semitones. The melody and timbre subtests assessed recognition of 12 commonly known melodies played with complex tones in an isochronous manner and eight musical instruments playing an identical five-note sequence, respectively. Testing was repeated for cochlear implant subjects to evaluate test-retest reliability. Normal-hearing volunteers were also tested to demonstrate differences in performance in the two populations. For cochlear implant subjects, pitch direction discrimination just-noticeable differences ranged from 1 to 8.0 semitones (Mean = 3.0, SD = 2.3). Melody and timbre recognition ranged from 0 to 94.4% correct (mean = 25.1, SD = 22.2) and 20.8 to 87.5% (mean = 45.3, SD = 16.2), respectively. Each subtest significantly correlated at least moderately with both Consonant-Nucleus-Consonant (CNC) word recognition scores and spondee recognition thresholds
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During World War 1, The American University in Washington D.C. was used by the U.S. Army as an experiment station for the development and testing of a variety of battlefield munitions including chemical weapons such as Mustard Gas, Phosgene, Ricin and Lewisite, among others. Afte...
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During World War 1, The American University in Washington D.C. was used by the U.S. Army as an experiment station for the development and testing of a variety of battlefield munitions including chemical weapons such as Mustard Gas, Phosgene, Ricin and Lewisite, among othe... -
1983-04-01
BAY, TACOMA, WASHINGTON PREPARED BY: FISHERIES RESEARCH INSTITUTE University of Washington DTIC C. A ELECTE JUL11 1985 DISTRIBUTIONSTATEMENT A...Nakatani 9. PERFORMING ORGANIZATION NAME AND ADDRESS 10. PROGRAM ELEMENT. PROJECT, TASK Fisheries Research Institute AREA & WORK UNIT NUMBERS School of... Fisheries WH-10 University of Washington Seattle, Washington 98195 11. CONTROLLING OFFICE NAME AND ADDRESS 12. REPORT DATE US Army Corps of Engineers
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Interview with David Tauben: University of Washington, Chief of the Division of Pain Medicine.
Tauben, David
2017-07-01
Dr Tauben is Clinical Professor jointly appointed in the Departments of Medicine and Anesthesia & Pain Medicine, and is the Hughes M & Katherine G Blake Endowed Professor, board certified in both Internal Medicine and Pain Medicine. He is also University of Washington (UW) Director of Medical Student and Resident Education in Pain Medicine, and Medical Director of UW TelePain, a tele-video-conferencing program intended to provide innovative pain education and consultative support to a five-state northwest regional primary care providers. He served as a member of the NIH National Pain Strategy task force on pain education and is principal investigator for the UW's prestigious NIH Pain Consortium Center of Excellence for Pain Education, leading curriculum development to extend the pain proficiency qualifications of interprofessional primary care providers. Dr Tauben is a member of the American Pain Society and the International Association for the Study of Pain special interest study groups on Pain Education. He is a founding member of the State of Washington Agency Medical Directors panel of medical experts developing opioid prescription guidelines for the state, and a regular clinical and content expert for regulatory and legislative bodies involved in public policy regarding pain medicine practice and standards. He speaks as a clinical expert in medical management of chronic pain, especially as it applies to primary care practices. Dr Tauben served as an expert for several US Centers for Disease Control clinical outreach programs and policy reviews advising primary care providers on how to prescribe opioids for chronic noncancer pain. He is annually recognized by his peers as recipient of regional awards in care of pain patients, and brings decades of clinical experience of best practice medication management of acute and chronic pain. Dr Tauben received his bachelors degree in philosophy from Yale University, medical degree from Tufts University School of
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PET - radiopharmaceutical facilities at Washington University Medical School - an overview
DOE Office of Scientific and Technical Information (OSTI.GOV)
Dence, C.S.; Welch, M.J.
1994-12-31
The PET program at Washington University has evolved over more than three decades of research and development in the use of positron-emitting isotopes in medicine and biology. In 1962 the installation of the first hospital cyclotron in the USA was accomplished. This first machine was an Allis Chalmers (AC) cyclotron and it was operated until July, 1990. Simultaneously with this cyclotron the authors also ran a Cyclotron Corporation (TCC) CS-15 cyclotron that was purchased in 1977. Both of these cyclotrons were maintained in-house and operated with a relatively small downtime (approximately 3.5%). After the dismantling of the AC machine inmore » 1990, a Japanese Steel Works 16/8 (JSW-16/8) cyclotron was installed in the vault. Whereas the AC cyclotron could only accelerate deuterons (6.2 MeV), the JSW - 16/8 machine can accelerate both protons and deuterons, so all of the radiopharmaceuticals can be produced on either of the two presently owned accelerators. At the end of May 1993, the medical school installed the first clinical Tandem Cascade Accelerator (TCA) a collaboration with Science Research Laboratories (SRL) of Somerville, MA. Preliminary target testing, design and development are presently under way. In 1973, the University installed the first operational PETT device in the country, and at present there is a large basic science and clinical research program involving more than a hundred staff in nuclear medicine, radiation sciences, neurology, neurosurgery, psychiatry, cardiology, pulmonary medicine, oncology, and surgery.« less
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The stink bugs (Hemiptera: Heteroptera: Pentatomidae) of Washington state
USDA-ARS?s Scientific Manuscript database
Froeschner (1988) records 23 species of stink bugs (Hemiptera: Heteroptera: Pentatomidae) as occurring in Washington state. Based onmaterial primarily housed in the M.T. James Entomological Collection at Washington State University, the number of species is increased to 47. Species recorded by Froes...
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Robins, Lynne; Ambrozy, Donna; Pinsky, Linda E
2006-11-01
The University of Washington Teaching Scholars Program (TSP) was established in 1995 to prepare faculty for local and national leadership and promote academic excellence by fostering a community of educational leaders to innovate, enliven, and enrich the environment for teaching and learning at the University of Washington (UW). Faculty in the Department of Medical Education and Biomedical Informatics designed and continue to implement the program. Qualified individuals from the UW Health Sciences Professional Schools and foreign scholars who are studying at the UW are eligible to apply for acceptance into the program. To date, 109 faculty and fellows have participated in the program, the majority of whom have been physicians. The program is committed to interprofessional education and seeks to diversify its participants. The curriculum is developed collaboratively with each cohort and comprises topics central to medical education and an emergent set of topics related to the specific interests and teaching responsibilities of the participating scholars. Core sessions cover the history of health professions education, learning theories, educational research methods, assessment, curriculum development, instructional methods, professionalism, and leadership. To graduate, scholars must complete a scholarly project in curriculum development, faculty development, or educational research; demonstrate progress towards construction of a teaching portfolio; and participate regularly and actively in program sessions. The TSP has developed and nurtured an active cadre of supportive colleagues who are transforming educational practice, elevating the status of teaching, and increasing the recognition of teachers. Graduates fill key teaching and leadership positions at the UW and in national and international professional organizations.
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Creating the future: IAIMS planning premises at the University of Washington.
Fuller, S S
1992-01-01
In September 1990, the University of Washington (UW) received a Phase I IAIMS Planning Grant from the National Library of Medicine and embarked upon a planning process involving the entire health sciences center. As a result of our relatively late entry into IAIMS planning, we have been able to learn from the experiences of other health sciences centers and to leverage our existing institutional efforts. Consequently, our progress has been rapid, and in a little over a year, we drafted a long-range plan and embarked on several related research and development projects. The hallmarks of our planning process include careful study of both the UW institutional environment and the experiences of other IAIMS institutions throughout the United States; broad, interdisciplinary participation of faculty, librarians, and administrators; an intensive educational process; a focus on people rather than technology; and, above all, leveraging of existing institutional and research projects that support our vision for the future. PMID:1326372
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NASA Technical Reports Server (NTRS)
Hobbs, Peter V.
2004-01-01
Work under this grant has been concerned with: (a) quality-assurance (QA) checking of the data collected on the University of Washington s (UW) Convair- 580 in the Chesapeake Lighthouse and Measurements for Satellites (CLAMS) field study in the Summer of 2001, (b) providing these data to the Langley DAAC, (c) providing specific data to users as requested, (d) analysis of portions of the data and publication of results, and (e) presentation of CLAMS results at workshop and conferences.
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NASA Astrophysics Data System (ADS)
Rohde, J. A.; Clarkson, M.; Houghton, J.; Chen, W.
2016-12-01
Science graduate students increasingly seek science communication training, yet many do not have easy access to training programs. Students often rely on a "do it yourself" approach to gaining communication skills, and student created science communication programs are increasingly found at universities and institutions across the U.S. In 2010, graduate students at the University of Washington led a grassroots effort to improve their own communication and outreach by creating "The Engage Program." With a focus on storytelling and public speaking, this graduate level course not only trains students in science communication but also gives them real world experience practicing that training at a public speaker series at Town Hall Seattle. The Engage Program was fortunate in that it was able to find institutional champions at University of Washington and secure funding to sustain the program over the long-term. However, many grassroots communication programs find it difficult to gain institutional support if there is a perceived lack of alignment with university priorities or lack of return on investment. In order to justify and incentivize institutional support for instruction in science communication, student leaders within the program initiated, designed and carried out an evaluation of their own program focused on assessing the impact of student communication, evaluating the effectiveness of the program in teaching communication skills, and quantifying the benefits of communication training to both the students and their institution. Project leaders created the opportunity for this evaluation by initiating a crowdfunding campaign, which has helped to further engage public support of science communication and incentivized student participation in the program, and may also inspire future program leaders to pursue similar program optimizations.
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1981-09-01
in catches made in shallow, mud- and sandflat habitats (B. Stevens, College of Fisheries , Univ. Washington, personal communication ). Considering the...DOUGLAS M. EGGERSDIrbsoUnntd - M FISHERIES RESEARCH INSTITUTE UNIVERSITY OF WASHINGTON of ArmynCrs SEPTEMBER 1981 ~~t~ ~~i; - It - ’ .-J~ . SECURITY...TASK Fisheries Research INsti tute AE OKUI UBR University of Washington Seattle, Washington 98195 j Lni’ 11. CONTROLLING OFFICE NAME AND ADDRESS
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The CTD2 Center at University of California San Francisco (UCSF-2) used an integrative genomics approach to reveal unidentified mRNA splicing patterns in neuroblastoma. Read the abstract Experimental Approaches Read the detailed Experimental Approaches
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History of the University of Washington Astronomy Department: 1965-1995
NASA Astrophysics Data System (ADS)
Lutz, Julie H.
2015-01-01
The Department of Astronomy of the University of Washington (UW) is celebrating its fiftieth anniversary this year, starting in 1965 when George Wallerstein and Paul Hodge joined Theodor Jacobsen to significantly expand research and initiate a graduate program. Three additional faculty members in astrophysical theory were added before the end of the decade: James Bardeen, Karl-Heinz Böhm and Erika Böhm-Vitense. In addition, plans were started to establish a research telescope in the State of Washington, primarily for training graduate students. The site survey for what eventually became Manastash Ridge Observatory (MRO) started in 1965. The 30-inch telescope at MRO in the eastern Cascades was dedicated in 1972.Four more faculty with a broad range of expertise were added in the 1970s and the number of graduate students expanded to about 15. Wallerstein was Chair of the department from 1965-1980. Part of his vision for the department was for UW astronomers to have access to a large, well-equipped telescope at a good observing site. He realized that such a goal would have to be accomplished in collaboration with other institutions and he spent years seeking partners.Newly-arrived faculty member Bruce Margon served as Chair from 1981-87 and from 1990-1995. In 1983 the Astrophysical Research Consortium (ARC) was formed with UW as a partner. UW played a major role in the construction of the ARC 3.5-m telescope in New Mexico, which was dedicated in 1994 and continues to function robustly. The department hired several more faculty with a variety of interests, both in multi-wavelength studies and astrophysical theory. An undergraduate astronomy major was added in the mid-1980s.In the mid-1980s ARC started to think about a sky survey which would encompass both imaging and spectroscopy. This became the original Sloan Digital Sky Survey (SDSS), which took place between 1990 and 1995, again with the UW as a major partner. At this time, UW Astronomy experienced growth in
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Advances in genome studies in plants and animals.
Appels, R; Nystrom-Persson, J; Keeble-Gagnere, G
2014-03-01
The area of plant and animal genomics covers the entire suite of issues in biology because it aims to determine the structure and function of genetic material. Although specific issues define research advances at an organism level, it is evident that many of the fundamental features of genome structure and the translation of encoded information to function share common ground. The Plant and Animal Genome (PAG) conference held in San Diego (California), in January each year provides an overview across all organisms at the genome level, and often it is evident that investments in the human area provide leadership, applications, and discoveries for researchers studying other organisms. This mini-review utilizes the plenary lectures as a basis for summarizing the trends in the genome-level studies of organisms, and the lectures include presentations by Ewan Birney (EBI, UK), Eric Green (NIH, USA), John Butler (NIST, USA), Elaine Mardis (Washington, USA), Caroline Dean (John Innes Centre, UK), Trudy Mackay (NC State University, USA), Sue Wessler (UC Riverside, USA), and Patrick Wincker (Genoscope, France). The work reviewed is based on published papers. Where unpublished information is cited, permission to include the information in this manuscript was obtained from the presenters.
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Federal Register 2010, 2011, 2012, 2013, 2014
2011-05-13
... Cultural Item: Museum of Anthropology at Washington State University, Pullman, WA AGENCY: National Park... possession of the Museum of Anthropology at Washington State University, Pullman, WA, that meets the... notice. One lot of stone, bone, and glass beads was given to the Museum of Anthropology at Washington...
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ERIC Educational Resources Information Center
Kenny, Eleanore
The progressively greater institutional commitment to the development and continuing support of new and innovative educational programs is demonstrated. Data were gathered from each institution (University of Washington, Washington State University, Western Washington State College, Central Washington State College, Eastern Washington State…
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Litvintseva, Anastasia P; Marsden-Haug, Nicola; Hurst, Steven; Hill, Heather; Gade, Lalitha; Driebe, Elizabeth M; Ralston, Cindy; Roe, Chandler; Barker, Bridget M; Goldoft, Marcia; Keim, Paul; Wohrle, Ron; Thompson, George R; Engelthaler, David M; Brandt, Mary E; Chiller, Tom
2015-01-01
We used real-time polymerase chain reaction and culture to demonstrate persistent colonization of soils by Coccidioides immitis, an agent of valley fever, in Washington State linked to recent human infections and located outside the endemic range. Whole-genome sequencing confirmed genetic identity between isolates from soil and one of the case-patients. Published by Oxford University Press on behalf of the Infectious Diseases Society of America 2014. This work is written by (a) US Government employee(s) and is in the public domain in the US.
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A universal genomic coordinate translator for comparative genomics
2014-01-01
Background Genomic duplications constitute major events in the evolution of species, allowing paralogous copies of genes to take on fine-tuned biological roles. Unambiguously identifying the orthology relationship between copies across multiple genomes can be resolved by synteny, i.e. the conserved order of genomic sequences. However, a comprehensive analysis of duplication events and their contributions to evolution would require all-to-all genome alignments, which increases at N2 with the number of available genomes, N. Results Here, we introduce Kraken, software that omits the all-to-all requirement by recursively traversing a graph of pairwise alignments and dynamically re-computing orthology. Kraken scales linearly with the number of targeted genomes, N, which allows for including large numbers of genomes in analyses. We first evaluated the method on the set of 12 Drosophila genomes, finding that orthologous correspondence computed indirectly through a graph of multiple synteny maps comes at minimal cost in terms of sensitivity, but reduces overall computational runtime by an order of magnitude. We then used the method on three well-annotated mammalian genomes, human, mouse, and rat, and show that up to 93% of protein coding transcripts have unambiguous pairwise orthologous relationships across the genomes. On a nucleotide level, 70 to 83% of exons match exactly at both splice junctions, and up to 97% on at least one junction. We last applied Kraken to an RNA-sequencing dataset from multiple vertebrates and diverse tissues, where we confirmed that brain-specific gene family members, i.e. one-to-many or many-to-many homologs, are more highly correlated across species than single-copy (i.e. one-to-one homologous) genes. Not limited to protein coding genes, Kraken also identifies thousands of newly identified transcribed loci, likely non-coding RNAs that are consistently transcribed in human, chimpanzee and gorilla, and maintain significant correlation of
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A universal genomic coordinate translator for comparative genomics.
Zamani, Neda; Sundström, Görel; Meadows, Jennifer R S; Höppner, Marc P; Dainat, Jacques; Lantz, Henrik; Haas, Brian J; Grabherr, Manfred G
2014-06-30
Genomic duplications constitute major events in the evolution of species, allowing paralogous copies of genes to take on fine-tuned biological roles. Unambiguously identifying the orthology relationship between copies across multiple genomes can be resolved by synteny, i.e. the conserved order of genomic sequences. However, a comprehensive analysis of duplication events and their contributions to evolution would require all-to-all genome alignments, which increases at N2 with the number of available genomes, N. Here, we introduce Kraken, software that omits the all-to-all requirement by recursively traversing a graph of pairwise alignments and dynamically re-computing orthology. Kraken scales linearly with the number of targeted genomes, N, which allows for including large numbers of genomes in analyses. We first evaluated the method on the set of 12 Drosophila genomes, finding that orthologous correspondence computed indirectly through a graph of multiple synteny maps comes at minimal cost in terms of sensitivity, but reduces overall computational runtime by an order of magnitude. We then used the method on three well-annotated mammalian genomes, human, mouse, and rat, and show that up to 93% of protein coding transcripts have unambiguous pairwise orthologous relationships across the genomes. On a nucleotide level, 70 to 83% of exons match exactly at both splice junctions, and up to 97% on at least one junction. We last applied Kraken to an RNA-sequencing dataset from multiple vertebrates and diverse tissues, where we confirmed that brain-specific gene family members, i.e. one-to-many or many-to-many homologs, are more highly correlated across species than single-copy (i.e. one-to-one homologous) genes. Not limited to protein coding genes, Kraken also identifies thousands of newly identified transcribed loci, likely non-coding RNAs that are consistently transcribed in human, chimpanzee and gorilla, and maintain significant correlation of expression levels across
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Legume Genome Initiative at the University of Oklahoma
DOE Office of Scientific and Technical Information (OSTI.GOV)
Bruce A. Roe
2004-02-27
Consolidated Appropriations Resolution, 2003 Conference Report for the Department of Energy's Biological and Environmental Research (BER) program provided $481,000 for the Legume Genome Initiative at the University of Oklahoma. These funds were used to support our research that is aimed at determining the entire sequence of the gene rich regions of the genome of the legume, Medicago truncatula, by allowing us to obtain a greater degree of finished BAC sequences from the draft sequences we have already obtained through research funded by the Noble Foundation. During the funding period we increased the number of Medicago truncatula BACs with finished (Bermudamore » standard) sequences from 109 to 359, and the total number of BACs for which we collected sequence data from 584 to 842, 359 of which reached phase 2 (ordered and oriented contigs). We also sequenced a series of pooled BAC clones that cover additional euchromatic (gene rich) genomic regions. This work resulted in 6 refereed publications, see below. Genes whose sequence was determined during this study included multiple members of the plant disease resistance (R-gene) family as well as several genes involved in flavinoid biosynthesis, nitrogen fixation and plant-microbial symbosis. This work also served as a prelude to obtaining NSF funding for the international collaborative effort to complete the entire sequence of the Medicago truncatula genomic euchromatic regions using a BAC based approach.« less
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Institutional Paralysis in the Press: The Cold War in Washington State.
ERIC Educational Resources Information Center
Baldasty, Gerald J.; Winfield, Betty Houchin
1981-01-01
A content analysis of four Washington state newspapers published in 1948 reveals that they did not provide fair coverage of the House UnAmerican Activities Committee's investigation of communist infiltration at the University of Washington. (FL)
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During World War I, The American University in Washington D.C. was used by the U.S. Am1y as an experiment station for the development and testing of a variety of battlefield munitions including chemical weapons such as Mustard Gas, Phosgene, Ricin and Lewisite, among others. Afte...
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Recent results from the University of Washington's 38 mm ram accelerator
NASA Technical Reports Server (NTRS)
De Turenne, J. A.; Chew, G.; Bruckner, A. P.
1992-01-01
The ram accelerator is a propulsive device that accelerates projectiles using gasdynamic cycles similar to those which generate thrust in airbreathing ramjets. The projectile, analogous to the centerbody of a ramjet, travels supersonically through a stationary tube containing a gaseous fuel and oxidizer mixture. The projectile itself carries no onboard propellant. A combustion zone follows the projectile and stabilizes the shock structure. The resulting pressure distribution continuously accelerates the projectile. Several modes of ram accelerator operation have been investigated experimentally and theoretically. At velocities below the Chapman-Jouguet (C-J) detonation speed of the propellant mixture, the thermally choked propulsion mode accelerates the projectiles. At projectile velocities between approximately 90 and 110 percent of the C-J speed, a transdetonative propulsion mode occurs. At velocities beyond 110 percent of the C-J speed, projectiles experience superdetonative propulsion. This paper presents recent experimental results from these propulsion modes obtained with the University of Washington's 38-mm bore ram accelerator. Data from investigations with hydrogen diluted-gas mixtures are also introduced.
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Goldman - Georgetown University | Division of Cancer Prevention
Principal Investigator: Radoslav (Rado) Goldman, PhDInstitution: Georgetown University, Washington, DC Subcontract Principal Investigator: Raja Mazumder, PhDInstitution: George Washington University |
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Adamson, Rosemary; Goodman, Richard B; Kritek, Patricia; Luks, Andrew M; Tonelli, Mark R; Benditt, Joshua
2015-04-01
The University of Washington was the first pulmonary and critical care medicine fellowship training program accredited by the Accreditation Council for Graduate Medical Education to create a dedicated clinician-educator fellowship track that has its own National Residency Matching Program number. This track was created in response to increasing demand for focused training in medical education in pulmonary and critical care. Through the Veterans Health Administration we obtained a stipend for a clinician-educator fellow to dedicate 12 months to training in medical education. This takes place predominantly in the second year of fellowship and is composed of several core activities: fellows complete the University of Washington's Teaching Scholars Program, a professional development program designed to train leaders in medical education; they teach in a variety of settings and receive feedback on their work from clinician-educator faculty and the learners; and they engage in scholarly activity, which may take the form of scholarship of teaching, integration, or investigation. Fellows are guided throughout this process by a primary mentor and a mentoring committee. Since funding became available in 2009, two of the three graduates to date have successfully secured clinician-educator faculty positions. Graduates uniformly believe that the clinician-educator track met their training goals better than the research-based track would have.
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1985-12-20
Kalles . 1976. Evaporation rates of methylene chloride, chloroform, 1,1,1-trichloroethane, trichloroethylene, tetrachoroethylene, and other chlorinated...State University (1969) M.S., Geology, University of Washington ( 1971 ) . . Ph.D., University of Washington (1979) " EXPERIENCE 1984 to Date Senior...ducted environmental assessments for Pacific Northwest construc- tion projects. L- 1971 Project Geologist, SEREM of Alaska (BRGM-France). Responsibil
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Outreach at Washington State University: a case study in costs and attendance
NASA Astrophysics Data System (ADS)
Bernhardt, Elizabeth A.; Bollen, Viktor; Bersano, Thomas M.; Mossman, Sean M.
2016-09-01
Making effective and efficient use of outreach resources can be difficult for student groups in smaller rural communities. Washington State University's OSA/SPIE student chapter desires well attended yet cost-effective ways to educate and inform the public. We designed outreach activities focused on three different funding levels: low upfront cost, moderate continuing costs, and high upfront cost with low continuing costs. By featuring our activities at well attended events, such as a pre-football game event, or by advertising a headlining activity, such as a laser maze, we take advantage of large crowds to create a relaxed learning atmosphere. Moreover, participants enjoy casual learning while waiting for a main event. Choosing a particular funding level and associating with well-attended events makes outreach easier. While there are still many challenges to outreach, such as motivating volunteers or designing outreach programs, we hope overcoming two large obstacles will lead to future outreach success.
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Universal features in the genome-level evolution of protein domains.
Cosentino Lagomarsino, Marco; Sellerio, Alessandro L; Heijning, Philip D; Bassetti, Bruno
2009-01-01
Protein domains can be used to study proteome evolution at a coarse scale. In particular, they are found on genomes with notable statistical distributions. It is known that the distribution of domains with a given topology follows a power law. We focus on a further aspect: these distributions, and the number of distinct topologies, follow collective trends, or scaling laws, depending on the total number of domains only, and not on genome-specific features. We present a stochastic duplication/innovation model, in the class of the so-called 'Chinese restaurant processes', that explains this observation with two universal parameters, representing a minimal number of domains and the relative weight of innovation to duplication. Furthermore, we study a model variant where new topologies are related to occurrence in genomic data, accounting for fold specificity. Both models have general quantitative agreement with data from hundreds of genomes, which indicates that the domains of a genome are built with a combination of specificity and robust self-organizing phenomena. The latter are related to the basic evolutionary 'moves' of duplication and innovation, and give rise to the observed scaling laws, a priori of the specific evolutionary history of a genome. We interpret this as the concurrent effect of neutral and selective drives, which increase duplication and decrease innovation in larger and more complex genomes. The validity of our model would imply that the empirical observation of a small number of folds in nature may be a consequence of their evolution.
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Fundamental studies of radar scattering from water surfaces: The Lake Washington experiment
NASA Technical Reports Server (NTRS)
Salam, A.; Bush, D.; Gogineni, S.; Zaide, A.
1991-01-01
The University of Kansas and the University of Washington conducted a series of experiments during July and August of 1989, and July and August of 1990, to study the effects of various geophysical parameters on radar backscatter. The experiments were conducted from a platform in Lake Washington. Measurements of backscattered power and radar range were made by the University of Kansas, and environmental data such as wind speed, wind direction, and air and water temperature were measured by the University of Washington. Results of preliminary data processing are described. Radar data were acquired using two radars, one that operated at C and X bands and another at Ka band. Measurements were made at W and HH antenna polarizations, at different angles of incidence and under various wind conditions. Plots of backscattered power, normalized radar cross section, and wave height, and the Modulation Transfer Functions of selected data are presented.
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Shaffer, Christopher D.; Alvarez, Consuelo; Bailey, Cheryl; Barnard, Daron; Bhalla, Satish; Chandrasekaran, Chitra; Chandrasekaran, Vidya; Chung, Hui-Min; Dorer, Douglas R.; Du, Chunguang; Eckdahl, Todd T.; Poet, Jeff L.; Frohlich, Donald; Goodman, Anya L.; Gosser, Yuying; Hauser, Charles; Hoopes, Laura L.M.; Johnson, Diana; Jones, Christopher J.; Kaehler, Marian; Kokan, Nighat; Kopp, Olga R.; Kuleck, Gary A.; McNeil, Gerard; Moss, Robert; Myka, Jennifer L.; Nagengast, Alexis; Morris, Robert; Overvoorde, Paul J.; Shoop, Elizabeth; Parrish, Susan; Reed, Kelynne; Regisford, E. Gloria; Revie, Dennis; Rosenwald, Anne G.; Saville, Ken; Schroeder, Stephanie; Shaw, Mary; Skuse, Gary; Smith, Christopher; Smith, Mary; Spana, Eric P.; Spratt, Mary; Stamm, Joyce; Thompson, Jeff S.; Wawersik, Matthew; Wilson, Barbara A.; Youngblom, Jim; Leung, Wilson; Buhler, Jeremy; Mardis, Elaine R.; Lopatto, David
2010-01-01
Genomics is not only essential for students to understand biology but also provides unprecedented opportunities for undergraduate research. The goal of the Genomics Education Partnership (GEP), a collaboration between a growing number of colleges and universities around the country and the Department of Biology and Genome Center of Washington University in St. Louis, is to provide such research opportunities. Using a versatile curriculum that has been adapted to many different class settings, GEP undergraduates undertake projects to bring draft-quality genomic sequence up to high quality and/or participate in the annotation of these sequences. GEP undergraduates have improved more than 2 million bases of draft genomic sequence from several species of Drosophila and have produced hundreds of gene models using evidence-based manual annotation. Students appreciate their ability to make a contribution to ongoing research, and report increased independence and a more active learning approach after participation in GEP projects. They show knowledge gains on pre- and postcourse quizzes about genes and genomes and in bioinformatic analysis. Participating faculty also report professional gains, increased access to genomics-related technology, and an overall positive experience. We have found that using a genomics research project as the core of a laboratory course is rewarding for both faculty and students. PMID:20194808
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A Partnership for Modeling the Marine Environment of Puget Sound, Washington
2009-03-30
Northwest National Marine Renewable Energy Center, a joint University of Washington - Oregon State project funded by the U.S. Department of Energy. e. A... Marine Renewable Energy Center (NNMREC), a joint Washington - Oregon State project to investigate extraction of wave and tidal energy sponsored by
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Geologic map of the Richland 1:100,000 quadrangle, Washington
DOE Office of Scientific and Technical Information (OSTI.GOV)
Reidel, S.P.; Fecht, K.R.
1993-09-01
This map of the Richland 1:100,000-scale quadrangle, Washington, shows the geology of one of fifteen complete or partial 1:100,000-scale quadrangles that cover the southeast quadrant of Washington. Geologic maps of these quadrangles have been compiled by geologists with the Washington Division of Geology and Earth Resources (DGER) and Washington State University and are the principal data sources for a 1:250,000-scale geologic map of the southeast quadrant of Washington, which is in preparation. Eleven of these quadrangles are being released as DGER open-file reports. The map of the Wenatchee quadrangle has been published by the US Geological Survey, and the Mosesmore » Lake, Ritzville quadrangles have already been released.« less
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Albrecht-Buehler, Guenter
2007-09-01
In genome duplexes that exceed 100 kb the frequency distributions of their trinucleotides (triplet profiles) are the same in both strands. This remarkable symmetry, sometimes called Chargaff's second parity rule, is not the result of base pairing, but can be explained as the result of countless inversions and inverted transpositions that occurred throughout evolution (G. Albrecht-Buehler, 2006, Proc. Natl. Acad. Sci. USA 103, 17828-17833). Furthermore, comparing the triplet profiles of genomes from a large number of different taxa and species revealed that they were not only strand-symmetrical, but even surprisingly similar to one another (majority profile; G. Albrecht-Buehler, 2007, Genomics 89, 596-601). The present article proposes that the same inversion/transposition mechanism(s) that created the strand symmetry may also explain the existence of the majority profile. Thus they may be key factors in the creation of an almost universal "format" in which genome sequences are written. One may speculate that this universality of genome format may facilitate horizontal gene transfer and, thus, accelerate evolution.
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An expanding universe of the non-coding genome in cancer biology.
Xue, Bin; He, Lin
2014-06-01
Neoplastic transformation is caused by accumulation of genetic and epigenetic alterations that ultimately convert normal cells into tumor cells with uncontrolled proliferation and survival, unlimited replicative potential and invasive growth [Hanahan,D. et al. (2011) Hallmarks of cancer: the next generation. Cell, 144, 646-674]. Although the majority of the cancer studies have focused on the functions of protein-coding genes, emerging evidence has started to reveal the importance of the vast non-coding genome, which constitutes more than 98% of the human genome. A number of non-coding RNAs (ncRNAs) derived from the 'dark matter' of the human genome exhibit cancer-specific differential expression and/or genomic alterations, and it is increasingly clear that ncRNAs, including small ncRNAs and long ncRNAs (lncRNAs), play an important role in cancer development by regulating protein-coding gene expression through diverse mechanisms. In addition to ncRNAs, nearly half of the mammalian genomes consist of transposable elements, particularly retrotransposons. Once depicted as selfish genomic parasites that propagate at the expense of host fitness, retrotransposon elements could also confer regulatory complexity to the host genomes during development and disease. Reactivation of retrotransposons in cancer, while capable of causing insertional mutagenesis and genome rearrangements to promote oncogenesis, could also alter host gene expression networks to favor tumor development. Taken together, the functional significance of non-coding genome in tumorigenesis has been previously underestimated, and diverse transcripts derived from the non-coding genome could act as integral functional components of the oncogene and tumor suppressor network. © The Author 2014. Published by Oxford University Press. All rights reserved. For Permissions, please email: journals.permissions@oup.com.
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Monsanto Gives Washington U. $23.5 Million.
ERIC Educational Resources Information Center
Culliton, Barbara J.
1982-01-01
Reviews various provisions of a five-year, $23.5-million research agreement between Washington University and the Monsanto Company. The scientific focus of this venture will be on proteins and peptides which modify cellular behavior. (SK)
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Overview of the University of Washington's Pre-Major in Astronomy Program
NASA Astrophysics Data System (ADS)
Haggard, Daryl; Pre-Major in Astronomy Program
2015-01-01
The fraction of science PhDs awarded to women, African American, Latino, and other minority students is currently far smaller than the fraction of the general population that these groups constitute (NSF 06-320, NSF 04-317). The future of Physics and Astronomy in the United States depends on recruiting and retaining these students in STEM majors and careers (Norman et al., 2009). The greatest obstacles for persistence in science reported by students are loss of interest, intimidation, poor advising, and lack of acceptance (Seymour & Hewitt, 1997). In 2005, a group of University of Washington graduate students created the Pre-Major in Astronomy Program (Pre-MAP) to connect incoming undergraduate students to authentic research experiences as a means of recruiting and retaining them in STEM. Pre-MAP was one of only 13 initiatives supported by the President's Diversity Appraisal Implementation Fund and has proved to be one of its greatest success stories. At its core is a 10-week seminar in which undergraduates learn astronomical research techniques (e.g., computing, data analysis, documentation, statistics, and literature review) and apply them to projects conducted in small groups, under the supervision of faculty and postdocs. Now in its tenth year, Pre-MAP has engaged more than 100 undergraduates — its ongoing success has made it a model for similar programs at UW and other universities.I will outline the beginnings, funding streams, and structure of this long-running diversity program. The Pre-MAP sessions that follow will highlight our best practices and lessons learned, and feature first-hand accounts from several of our fantastic Pre-MAP alumni.
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Archaeological Investigations at Site 45-DO-282, Chief Joseph Dam Project, Washington
1984-01-01
and Mr. Joseph, in particular. Excavations at 45-00-282 were carried out by a joint Western Washington University and University of Washington field...not terminate in a snap fracture . A few have been snapped jcross both the dorsal and proximal ends. Except for these few C4’ aa CL, cw V. .f q-1f1410... fractures , it is virtually •-:1 impossible to classify breakage as Intentional, or as an accidental product of manufacture. Many of the core flutes
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Damas, Joana; O'Connor, Rebecca; Farré, Marta; Lenis, Vasileios Panagiotis E; Martell, Henry J; Mandawala, Anjali; Fowler, Katie; Joseph, Sunitha; Swain, Martin T; Griffin, Darren K; Larkin, Denis M
2017-05-01
Most recent initiatives to sequence and assemble new species' genomes de novo fail to achieve the ultimate endpoint to produce contigs, each representing one whole chromosome. Even the best-assembled genomes (using contemporary technologies) consist of subchromosomal-sized scaffolds. To circumvent this problem, we developed a novel approach that combines computational algorithms to merge scaffolds into chromosomal fragments, PCR-based scaffold verification, and physical mapping to chromosomes. Multigenome-alignment-guided probe selection led to the development of a set of universal avian BAC clones that permit rapid anchoring of multiple scaffolds to chromosomes on all avian genomes. As proof of principle, we assembled genomes of the pigeon ( Columbia livia ) and peregrine falcon ( Falco peregrinus ) to chromosome levels comparable, in continuity, to avian reference genomes. Both species are of interest for breeding, cultural, food, and/or environmental reasons. Pigeon has a typical avian karyotype (2n = 80), while falcon (2n = 50) is highly rearranged compared to the avian ancestor. By using chromosome breakpoint data, we established that avian interchromosomal breakpoints appear in the regions of low density of conserved noncoding elements (CNEs) and that the chromosomal fission sites are further limited to long CNE "deserts." This corresponds with fission being the rarest type of rearrangement in avian genome evolution. High-throughput multiple hybridization and rapid capture strategies using the current BAC set provide the basis for assembling numerous avian (and possibly other reptilian) species, while the overall strategy for scaffold assembly and mapping provides the basis for an approach that (provided metaphases can be generated) could be applied to any animal genome. © 2017 Damas et al.; Published by Cold Spring Harbor Laboratory Press.
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O'Connor, Rebecca; Lenis, Vasileios Panagiotis E.; Martell, Henry J.; Mandawala, Anjali; Fowler, Katie; Joseph, Sunitha; Swain, Martin T.; Griffin, Darren K.; Larkin, Denis M.
2017-01-01
Most recent initiatives to sequence and assemble new species’ genomes de novo fail to achieve the ultimate endpoint to produce contigs, each representing one whole chromosome. Even the best-assembled genomes (using contemporary technologies) consist of subchromosomal-sized scaffolds. To circumvent this problem, we developed a novel approach that combines computational algorithms to merge scaffolds into chromosomal fragments, PCR-based scaffold verification, and physical mapping to chromosomes. Multigenome-alignment-guided probe selection led to the development of a set of universal avian BAC clones that permit rapid anchoring of multiple scaffolds to chromosomes on all avian genomes. As proof of principle, we assembled genomes of the pigeon (Columbia livia) and peregrine falcon (Falco peregrinus) to chromosome levels comparable, in continuity, to avian reference genomes. Both species are of interest for breeding, cultural, food, and/or environmental reasons. Pigeon has a typical avian karyotype (2n = 80), while falcon (2n = 50) is highly rearranged compared to the avian ancestor. By using chromosome breakpoint data, we established that avian interchromosomal breakpoints appear in the regions of low density of conserved noncoding elements (CNEs) and that the chromosomal fission sites are further limited to long CNE “deserts.” This corresponds with fission being the rarest type of rearrangement in avian genome evolution. High-throughput multiple hybridization and rapid capture strategies using the current BAC set provide the basis for assembling numerous avian (and possibly other reptilian) species, while the overall strategy for scaffold assembly and mapping provides the basis for an approach that (provided metaphases can be generated) could be applied to any animal genome. PMID:27903645
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ERIC Educational Resources Information Center
Burke, Rachel; Martin, Gloria
2014-01-01
Washington Student Achievement Council's 10-Year Roadmap sets a goal for 2023 of having 70 percent of Washington adults (ages 25-44) receive a postsecondary credential. At the same time, dramatic cuts in state funding for higher education, particularly since 2008, have shifted more of the cost of higher education onto students and families, making…
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Kaviani, Hosein; Esmaili, Yaghob; Ebrahimkhani, Narges; Manesh, Alireza Amin
2011-01-01
Objective The psychometric properties and factor structure of the Persian Padua Inventory Washington State University Revision (PI-WSUR), a measure of obsessive- compulsive phenomena, was examined in a non-clinical sample of 348 Iranian university students. Method The PI-WSUR was translated into Persian, and its back translation was controlled by the author inventory. A pilot study based on cultural differences was carried out on twenty students. The study subjects consisted of 348 university students, and they completed PPI, OCI-R, MOCI, BAI, STAI, BDI-II and the demographic inventory. Results The factor analysis of the PI-WSUR, exhibited eight factors similar but not identical with factor structure in previous studies. as the eight factors are as follows: contamination obsessions; washing compulsions; ordering compulsions; checking compulsions; obsessional thoughts to harm self/others; obsessional thoughts about violence; obsessional impulses to harm self/others; and obsessional impulses to steal. The result also indicated excellent internal consistency (Cronbach alpha= 0.92), Spearman split test (0.95) and test- retest (r= 0.77). We assessed the concurrent validity of the PPI in relation to the Obsessive Compulsive Inventory-Revised (OCI-R), and the Maudsley Obsessive- Compulsive Inventory (MOCI). Conclusion The Iranian version of the PI to some extend remains the sound psychometric properties of the original version. PMID:22952515
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Southwest Washington, Urban Renewal Area, Bounded by Independence Avenue, Washington ...
Southwest Washington, Urban Renewal Area, Bounded by Independence Avenue, Washington Avenue, South Capitol Street, Canal Street, P Street, Maine Avenue & Washington Channel, Fourteenth Street, D Street, & Twelfth Street, Washington, District of Columbia, DC
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Fryer-Edwards, Kelly; Van Eaton, Erik; Goldstein, Erika A; Kimball, Harry R; Veith, Richard C; Pellegrini, Carlos A; Ramsey, Paul G
2007-11-01
The University of Washington (UW) School of Medicine is in the midst of an emerging ecology of professionalism. This initiative builds on prior work focusing on professionalism at the student level and moves toward the complete integration of a culture of professionalism within the UW medical community of including staff, faculty, residents, and students. The platform for initiating professionalism as institutional culture is the Committee on Continuous Professionalism Improvement, established in November 2006. This article reviews three approaches to organizational development used within and outside medicine and highlights features that are useful for enhancing an institutional culture of professionalism: organizational culture, safety culture, and appreciative inquiry. UW Medicine has defined professional development as a continuous process, built on concrete expectations, using mechanisms to facilitate learning from missteps and highlighting strengths. To this end, the school of medicine is working toward improvements in feedback, evaluation, and reward structures at all levels (student, resident, faculty, and staff) as well as creating opportunities for community dialogues on professionalism issues within the institution. Throughout all the Continuous Professionalism Improvement activities, a two-pronged approach to cultivating a culture of professionalism is taken: celebration of excellence and attention to accountability.
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2005-01-01
bioengineering programs and activities of The Catholic University of America, Georgetown University, The George Washington University and Howard ... University . A prime component of WABME activities is a quarterly series of research workshops, which bring together problem-rich biomedical disciplines and
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Toward a Modern Science of Obesity at Washington University: How We Do It and What is the Payoff?
Colditz, Graham A; Gehlert, Sarah; Bowen, Deborah J; Carson, Kenneth; Hovmand, Peter S; Lee, Jung Ae; Moley, Kelle H
2016-07-01
In our Cancer Prevention Program at Washington University in Saint Louis (WUSTL), we have made extraordinary efforts to create the kind of cancer prevention and control program that is both translational and transdisciplinary in nature, to accelerate the march from basic discoveries to population change. Here we present an overview of our obesity-related research currently ongoing in our Center, paying particular attention to both the translational- transdisciplinary process and to community-based participatory research. We end with our future directions for improving obesity-related cancer outcomes research. Cancer Prev Res; 9(7); 503-8. ©2016 AACR. ©2016 American Association for Cancer Research.
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Jerry F. Franklin; Miles Hemstrom; Robert Van Pelt; Joe Buchanan; Sabra Hull; Rex Crawford; Steve Curry; Walt Obermeyer
2007-01-01
An inventory was conducted of old forests on state trust lands in Eastern Washington managed by the Washington State Department of Natural Resources (DNR), in response to legislative direction (ESSB 6384, Section 189,2006). This inventory was conducted with guidance from an independent science panel, chaired by Jerry Franklin of the University of Washington. As...
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Legal Issues and Small High Schools: Strategies to Support Innovation in Washington State
ERIC Educational Resources Information Center
Warner-King, Kelly; Price, Mitch
2004-01-01
In 2003, education program officials at the Bill & Melinda Gates Foundation asked attorneys at the University of Washington's Center on Reinventing Public Education to explore legal issues affecting the establishment and operation of small high schools in Washington State. Although this guide will be of interest to small school advocates…
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University of Washington Clinical Neutron Facility: Report on 26 Years of Operation
NASA Astrophysics Data System (ADS)
Laramore, George E.; Emery, Robert; Reid, David; Banerian, Stefani; Kalet, Ira; Jacky, Jonathan; Risler, Ruedi
2011-12-01
Particle radiotherapy facilities are highly capital intensive and must operate over decades to recoup the original investment. We describe the successful, long-term operation of a neutron radiotherapy center at the University of Washington, which has been operating continuously since September 1984. To date, 2836 patients have received neutron radiotherapy. The mission of the facility has also evolved to include the production of unique radioisotopes that cannot be made with the low-energy cyclotrons more commonly found in nuclear medicine departments. The facility is also used for neutron damage testing for industrial devices. In this paper, we describe the challenges of operating such a facility over an extended time period, including a planned maintenance and upgrade program serving diverse user groups, and summarize the major clinical results in terms of tumor control and normal tissue toxicity. Over time, the mix of patients being treated has shifted from common tumors such as prostate cancer, lung cancer, and squamous cell tumors of the head and neck to the rarer tumors such as salivary gland tumors and sarcomas due to the results of clinical trials. Current indications for neutron radiotherapy are described and neutron tolerance doses for a range of normal tissues presented.
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Hydration and Cooling Practices Among Farmworkers in Oregon and Washington.
Bethel, Jeffrey W; Spector, June T; Krenz, Jennifer
2017-01-01
Although recommendations for preventing occupational heat-related illness among farmworkers include hydration and cooling practices, the extent to which these recommendations are universally practiced is unknown. The objective of this analysis was to compare hydration and cooling practices between farmworkers in Oregon and Washington. A survey was administered to a purposive sample of Oregon and Washington farmworkers. Data collected included demographics, work history and current work practices, hydration practices, access and use of cooling measures, and headwear and clothing worn. Oregon farmworkers were more likely than those in Washington to consume beverages containing sugar and/or caffeine. Workers in Oregon more frequently reported using various cooling measures compared with workers in Washington. Availability of cooling measures also varied between the two states. These results highlight the large variability between workers in two states regarding access to and use of methods to stay cool while working in the heat.
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McDonald, Sandra A; Mardis, Elaine R; Ota, David; Watson, Mark A; Pfeifer, John D; Green, Jonathan M
2012-07-01
As part of the molecular revolution sweeping medicine, comprehensive genomic studies are adding powerful dimensions to medical research. However, their power exposes new regulatory, strategic, and quality assurance challenges for biorepositories. A key issue is that unlike other research techniques commonly applied to banked specimens, nucleic acid sequencing, if sufficiently extensive, yields data that could identify a patient. This evolving paradigm renders the concepts of anonymized and anonymous specimens increasingly outdated. The challenges for biorepositories in this new era include refined consent processes and wording, selection and use of legacy specimens, quality assurance procedures, institutional documentation, data sharing, and interaction with institutional review boards. Given current trends, biorepositories should consider these issues now, even if they are not currently experiencing sample requests for genomic analysis. We summarize our current experiences and best practices at Washington University Medical School, St Louis, MO, our perceptions of emerging trends, and recommendations.
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McDonald, Sandra A.; Mardis, Elaine R.; Ota, David; Watson, Mark A.; Pfeifer, John D.; Green, Jonathan M.
2012-01-01
As part of the molecular revolution sweeping medicine, comprehensive genomic studies are adding powerful dimensions to medical research. However, their power exposes new regulatory, strategic, and quality assurance challenges for biorepositories. A key issue is that unlike other research techniques commonly applied to banked specimens, nucleic acid sequencing, if sufficiently extensive, yields data that could identify a patient. This evolving paradigm renders the concepts of anonymized and anonymous specimens increasingly outdated. The challenges for biorepositories in this new era include refined consent processes and wording, selection and use of legacy specimens, quality assurance procedures, institutional documentation, data sharing, and interaction with institutional review boards. Given current trends, biorepositories should consider these issues now, even if they are not currently experiencing sample requests for genomic analysis. We summarize our current experiences and best practices at Washington University Medical School, St Louis, MO, our perceptions of emerging trends, and recommendations. PMID:22706855
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The Role of Federal Troops in Quelling Civil Disturbance in Washington, DC, April 1968
1993-01-01
15:17’ TAMU HISCTORY DEPT PAG’E . 002 THE USE OF FEDERAL TROOPS IN QUELLING CIVIL UNREST IN WASHINGTON , D.C., APRIL 1968 A Thesis By BARRYE LA TROYE ...BARRYE LA TROYE PRICE Submitted to Texas A&M University in partial fulfillment of the requirements for the degree of MASTER OF ARTS Approved as to style...Federal Troops in Quelling Civil Unrest in Washington, D.C., April 1968. (May 1994) Barrye La Troye Price, B.B.A., University of Houston Chair of
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The field of immunotherapy is rapidly advancing and genomics techniques are being incorporated to add a “precision” approach. OCG spoke with two CTD2 investigators from the Fred Hutchinson Cancer Research Center (FHCRC) about new advances in immunotherapy. For the first article of this two-part series, we interviewed Martin McIntosh, Ph.D., member of the Fred Hutchinson Translational Research program and previously Program Head in Computational Biology at FHCRC/University of Washington Comprehensive Cancer Center.
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USDA-ARS?s Scientific Manuscript database
Symptoms of powdery mildew were observed on a Coreopsis cultivar in the Horticulture and Landscape Architecture Garden on the Washington State University campus, Pullman, Whitman County, Washington. White to off-white sporulating mycelial areas were ~5mm in diam to confluent and confined to adaxial...
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The Advance Mentoring-For Lunch Series for Women Faculty in STEM at the University of Washington
NASA Astrophysics Data System (ADS)
Yen, Joyce W.; Quinn, Kate; Carrigan, Coleen; Litzler, Elizabeth; Riskin, Eve A.
Given the increasingly smaller number of women in science, technology, engineering, and mathematics (STEM) fields as one progresses through the academic pipeline, it is often very difficult for women in STEM faculty positions to find a community of women and identify women mentors, especially at the upper rungs of the academic ladder. Group mentoring opportunities are one strategy to connect women STEM faculty and generate greater interest and success in academic leadership. In 2003 the University of Washington (UW) ADVANCE program introduced the Mentoring-for-Leadership lunch series to encourage women faculty to consider leadership; expose women faculty to various career paths; and build a community of women faculty in STEM. This paper describes the UW program, the literature that informs the program, and the participants' experiences. This paper also offers recommendations for replicating this program at other campuses.
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1988-01-01
and Forming and The Titanium Committees of TMS, held in Blaine, Washington, August 1-4, 1988. Edited by C. Howard Hamilton Washington State University...indebted to Washington State University for hosting the conference, and to The Shaping and Forming Committee and the Titanium Committee of TMS for...Superplastic Nickel-Base and Titanium -Base Alloys ...................................................... 353 Michio Yamazaki Development of Superplaatic
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Federal Register 2010, 2011, 2012, 2013, 2014
2011-02-16
... Anthropology, Seattle, WA; Correction AGENCY: National Park Service, Interior. ACTION: Notice; correction... of Washington, Department of Anthropology, Seattle, WA. The human remains were removed from... Notice, the University of Washington, Department of Anthropology, had believed it was in control of the...
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Recommendation for Faculty Salaries in Washington Public Higher Education 1977-79. Report No. 77-17.
ERIC Educational Resources Information Center
Curry, Denis; Johnson, Jackie
This document provides an analysis of faculty salary structures in Washington state colleges, universities, and community colleges. Comparative analysis of national averages for faculty salaries and compensation show that Washington institutions are below the national average in terms of faculty salaries, although the amount expended for salaries…
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NASA Astrophysics Data System (ADS)
Thompson, L.; Bertram, M. A.
2012-12-01
Education on climate change occurs in many departments at large research universities, but providing a coordinated educational experience for students in this topic is challenging. Departmental boundaries, accounting for student credit hours, and curricula inertia create roadblocks to the creation of interdisciplinary curriculum for both graduate and undergraduate students. We describe a hierarchy of interdisciplinary programs that reach students from seniors in high school to graduate students, targeting students from a variety of disciplines. The UWHS (University of Washington in the High School) program allows high school teachers to be trained to teach UW courses to their own high school students at their own school. The students who enroll receive a UW grade and credit for the course (as well as high school credit). A UWHS course on Climate and Climate Change (Atmospheric Sciences 211) was created in 2011 supported by training to high school science teachers on the fundamentals of climate science. For the 2012-13 academic year we anticipate at least 5 schools in Washington State will be offering this course. Once students matriculate at UW, 211 serves as a prerequisite for the Climate Minor that began in 2011. The minor is hosted by the departments of Atmospheric Sciences, Earth and Space Sciences and Oceanography, offering instruction in three focus areas: climate chemistry and biology, the physical climate, and past climate and ice. Students also take an integrative seminar where they are required to communicate to both scientific and non-scientific audiences some topic in climate science. Students enrolled in graduate programs at UW can participate in the Graduate Certificate in Climate Science that began 2008. The certificate gives students instruction in climate science covering the same topic areas as the minor and with a capstone project where student communicate some aspect of climate science to a non-physical science audience. Projects have included
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Hydration and Cooling Practices Among Farmworkers in Oregon and Washington
Bethel, Jeffrey W.; Spector, June T.; Krenz, Jennifer
2018-01-01
Objectives Although recommendations for preventing occupational heat-related illness among farmworkers include hydration and cooling practices, the extent to which these recommendations are universally practiced is unknown. The objective of this analysis was to compare hydration and cooling practices between farmworkers in Oregon and Washington. Methods A survey was administered to a purposive sample of Oregon and Washington farmworkers. Data collected included demographics, work history and current work practices, hydration practices, access and use of cooling measures, and headwear and clothing worn. Results Oregon farmworkers were more likely than those in Washington to consume beverages containing sugar and/or caffeine. Workers in Oregon more frequently reported using various cooling measures compared with workers in Washington. Availability of cooling measures also varied between the two states. Conclusions These results highlight the large variability between workers in two states regarding access to and use of methods to stay cool while working in the heat. PMID:28402203
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GO-FAANG meeting: A gathering on functional annotation of animal genomes
USDA-ARS?s Scientific Manuscript database
The FAANG (Functional Annotation of Animal Genomes) Consortium recently held a Gathering On FAANG (GO-FAANG) Workshop in Washington, DC on October 7-8, 2015. This consortium is a grass-roots organization formed to advance the annotation of newly assembled genomes of non-model organisms (www.faang.or...
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Fan, Xiang-yu; Lin, Yan-ping; Liao, Guo-jian; Xie, Jian-ping
2015-12-01
Zinc finger nuclease, transcription activator-like effector nuclease, and clustered regularly interspaced short palindromic repeats/Cas9 nuclease are important targeted genome editing technologies. They have great significance in scientific research and applications on aspects of functional genomics research, species improvement, disease prevention and gene therapy. There are past or ongoing disputes over ownership of the intellectual property behind every technology. In this review, we summarize the patents on these three targeted genome editing technologies in order to provide some reference for developing genome editing technologies with self-owned intellectual property rights and some implications for current innovation and entrepreneurship education in universities.
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78 FR 26249 - Drawbridge Operation Regulation; Lake Washington Ship Canal, Seattle, WA
Federal Register 2010, 2011, 2012, 2013, 2014
2013-05-06
...The Coast Guard has issued a temporary deviation from the operating schedule that governs the Montlake Bridge across the Lake Washington Ship Canal, mile 5.2, at Seattle, WA, and the University Bridge across the Lake Washington Ship Canal, mile 4.3, at Seattle, WA. This deviation is necessary to accommodate the ``Beat the Bridge'' foot race. This deviation allows the bridges to remain in the closed position to allow safe movement of event participants.
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Crawford, S; Halbrook, B
1990-01-01
In an era of great technological and socioeconomic changes, the Washington University School of Medicine conceptualized and built its first Library and Biomedical Communications Center in seventy-eight years. The planning process, evolution of the electronic library, and translation of functions into operating spaces are discussed. Since 1983, when the project was approved, a whole range of information technologies and services have emerged. The authors consider the kind of library that would operate in a setting where people can do their own searches, order data and materials through an electronic network, analyze and manage information, and use software to create their own publications. Images PMID:2393757
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Toward a Comprehensive Genomic Analysis of Cancer - TCGA
The National Cancer Institute (NCI) and National Human Genome Research Institute (NHGRI) convened a "Toward a Comprehensive Genomic Analysis of Cancer" workshop in Washington, D.C. This workshop brought together physicians, basic scientists and other members of the U.S. and international cancer communities to assist in outlining the most effective strategies for the development of a successful project. Information about this workshop is reported in the Executive Summary.
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The Impact of NSF-funded Physics Education Research at the University of Washington
NASA Astrophysics Data System (ADS)
Heron, Paula
2015-03-01
It is now well known that many students who complete introductory physics courses are unable to apply fundamental concepts in situations that involve qualitative reasoning. Systematic investigations have helped researchers understand why so many students fail to develop robust and coherent conceptual frameworks, and have led to the development of new teaching practices and materials that are far more effective than conventional ones. The Physics Education Group at the University of Washington has played a leading role in raising awareness of the need to improve instruction, and in supporting physics faculty in their efforts to do so. With support from the National Science Foundation, the group has helped build a research base that instructors can draw on, and has produced practical, flexible instructional materials that promote deeper learning in physics classrooms. Both ``Tutorials in Introductory Physics'' (Pearson, 2002) and ``Physics by Inquiry'' (Wiley, 1996) have been developed in an iterative process in which ongoing assessment of student learning plays an integral role. These materials have had a widespread and significant impact on physics teaching and on student learning from kindergarten through graduate school. In this talk I will describe the role of research in curriculum development, and speculate on the next generation of tools and resources to support physics teaching and learning.
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Astronomy 101 in Washington State High Schools
NASA Astrophysics Data System (ADS)
Lutz, Julie H.; Garner, S.; Stetter, T.; McKeever, J.; Santo Pietro, V.
2011-01-01
The University of Washington in the High School (UWHS) program enables high schools to offer the 5 quarter credits Astronomy 101 (Astr 101) course for college credits. The credits are transferable to most colleges and universities. The course provides an alternative to advance placement courses and programs such as Washington's Running Start whereby high school students take courses at community colleges. Astr 101 focuses on stars, galaxies and the universe, as well as background topics such as gravitation, electromagnetic radiation and telescopes. The course satisfies the UW "natural world” and "quantitative/symbolic reasoning” distribution requirements. Students must pay a fee to enroll, but the credits cost less than half what they would cost for the course if taken on one of the UW campuses. The course can be offered as either one semester or full-year at the high school. Teachers who offer Astr 101 must be approved in advance by the UW Astronomy Department, and their syllabi and course materials approved also. Teachers receive orientation, professional development opportunities, classroom visits and support (special web site, answering questions, making arrangements for campus visits, planetarium visits) from astronomy department course coordinator. The UWHS Astr 101 program has produced positive outcomes for the astronomy department, the participating teachers and the students who complete the course. In this poster we will discuss our 5 years of experience with offering Astr 101, including benefits to the students, teachers, high schools, university and department, student outcomes, course assessments and resources for offering the course.
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Origins of the Human Genome Project.
Watson, J D; Cook-Deegan, R M
1991-01-01
Caenorhabditis elegans by a collaboration between Washington University and the Medical Research Council laboratory in Cambridge, U.K. This project is now turning to sequencing C. elegans DNA as a logical extension of this work. These are but the first fruits of the genome project. There is much more to come.
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75 FR 28757 - Security Zone; Potomac River, Washington Channel, Washington, DC
Federal Register 2010, 2011, 2012, 2013, 2014
2010-05-24
...-AA87 Security Zone; Potomac River, Washington Channel, Washington, DC AGENCY: Coast Guard, DHS. ACTION: Temporary final rule. SUMMARY: The Coast Guard is establishing a temporary security zone in certain waters of Washington Channel on the Potomac River. The security zone is necessary to provide for the...
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Maggi, Elaine; Montagna, Cristina
2015-12-01
The American Association for Cancer Research (AACR) Precision Medicine Series "Integrating Clinical Genomics and Cancer Therapy" took place June 13-16, 2015 in Salt Lake City, Utah. The conference was co-chaired by Charles L. Sawyers form Memorial Sloan Kettering Cancer Center in New York, Elaine R. Mardis form Washington University School of Medicine in St. Louis, and Arul M. Chinnaiyan from University of Michigan in Ann Arbor. About 500 clinicians, basic science investigators, bioinformaticians, and postdoctoral fellows joined together to discuss the current state of Clinical Genomics and the advances and challenges of integrating Next Generation Sequencing (NGS) technologies into clinical practice. The plenary sessions and panel discussions covered current platforms and sequencing approaches adopted for NGS assays of cancer genome at several national and international institutions, different approaches used to map and classify targetable sequence variants, and how information acquired with the sequencing of the cancer genome is used to guide treatment options. While challenges still exist from a technological perspective, it emerged that there exists considerable need for the development of tools to aid the identification of the therapy most suitable based on the mutational profile of the somatic cancer genome. The process to match patients to ongoing clinical trials is still complex. In addition, the need for centralized data repositories, preferably linked to well annotated clinical records, that aid sharing of sequencing information is central to begin understanding the contribution of variants of unknown significance to tumor etiology and response to therapy. Here we summarize the highlights of this stimulating four-day conference with a major emphasis on the open problems that the clinical genomics community is currently facing and the tools most needed for advancing this field. Copyright © 2015. Published by Elsevier B.V. All rights reserved.
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Geologic map of the Priest Rapids 1:100,000 quadrangle, Washington
DOE Office of Scientific and Technical Information (OSTI.GOV)
Reidel, S.P.; Fecht, K.R.
1993-09-01
This map of the Priest Rapids 1:100,000-scale quadrangle, Washington, shows the geology of one of fifteen complete or partial 1:100,000-scale quadrangles that cover the southeast quadrant of Washington. Geologic maps of these quadrangles have been compiled by geologists with the Washington Division of Geology and Earth Resources (DGER) and Washington State University and are the principal data sources for a 1:250,000scale geologic map of the southeast quadrant of Washington, which is in preparation. Eleven of those quadrangles are being released as DGER open-file reports (listed below). The map of the Wenatchee quadrangle has been published by the US Geological Surveymore » (Tabor and others, 1982), and the Moses Lake (Gulick, 1990a), Ritzville (Gulick, 1990b), and Rosalia (Waggoner, 1990) quadrangles have already been released. The geology of the Priest Rapids quadrangle has not previously been compiled at 1:100,000 scale. Furthermore, this is the first 1:100,000 or smaller scale geologic map of the area to incorporate both bedrock and surficial geology. This map was compiled in 1992, using published and unpublished geologic maps as sources of data.« less
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1971 Washington timber harvest.
Brian R. Wall
1972-01-01
Washington's 1971 timber harvest of 6.45 billion board feet was nearly the same as the 1970 harvest level. The total timber harvest on public lands increased nearly 4 percent with a 30-percent increase in eastern Washington more than offsetting a 5-percent decline in western Washington. Part of the increase in eastern Washington reflects salvage of a large volume...
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Federal Register 2010, 2011, 2012, 2013, 2014
2012-03-16
... sole responsibility of the museum, institution or Federal agency that has control of the Native... Department of Anthropology professional staff in consultation with representatives of the Confederated Tribes... Memorial Washington State Museum (Burke Museum) accession ledger, Daugherty collected two femora and one...
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A Workshop Report on Wheat Genome Sequencing
Gill, Bikram S.; Appels, Rudi; Botha-Oberholster, Anna-Maria; Buell, C. Robin; Bennetzen, Jeffrey L.; Chalhoub, Boulos; Chumley, Forrest; Dvořák, Jan; Iwanaga, Masaru; Keller, Beat; Li, Wanlong; McCombie, W. Richard; Ogihara, Yasunari; Quetier, Francis; Sasaki, Takuji
2004-01-01
Sponsored by the National Science Foundation and the U.S. Department of Agriculture, a wheat genome sequencing workshop was held November 10–11, 2003, in Washington, DC. It brought together 63 scientists of diverse research interests and institutions, including 45 from the United States and 18 from a dozen foreign countries (see list of participants at http://www.ksu.edu/igrow). The objectives of the workshop were to discuss the status of wheat genomics, obtain feedback from ongoing genome sequencing projects, and develop strategies for sequencing the wheat genome. The purpose of this report is to convey the information discussed at the workshop and provide the basis for an ongoing dialogue, bringing forth comments and suggestions from the genetics community. PMID:15514080
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Working Together: Wellness and Academic Achievement at Tribal Colleges and Universities
ERIC Educational Resources Information Center
Duran, Bonnie; Magarati, Maya; Parker, Myra; Egashira, Leo; Kipp, Billie Jo
2013-01-01
This article describes the activities of the Indigenous Wellness Research Institute (IWRI) at the University of Washington, Washington State, in collaborating with tribal colleges and universities (TCUs) to examine alcohol, drug, and mental health issues among Native students. The authors provide first steps for the development of culturally…
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University of Washington Airborne Studies in Support of the CLAMS-2001 Field Study
NASA Technical Reports Server (NTRS)
Hobbs, Peter V.
2003-01-01
The main activity under this grant was participation in the Chesapeake Lighthouse and Aircraft Measurements for Satellites (CLAMS) field study from 10 July through 2 August 2001. The Cloud and Aerosol Research Group (CARG) from the University of Washington (UW) flew its Convair-580 research aircraft on thirteen occasions, for a total of 45 research flight hours, in support of CLAMS. Some of the main accomplishments of these flights were: 1) Aerosol and trace gas measurements and sunphotometer measurements of aerosol optical depth and column water vapor and ozone from close to Ocean surface to approx. 10,000 ft off Delmarva Peninsula on various occasions; 2) Measurements of aerosol properties on seven occasions beneath the Terra satellite, once beneath AVHRR, and five times beneath the ER-2 aircraft; 3) Measurements of aerosol properties in the vicinity of the (CERES instrumented) Chesapeake Bay lighthouse (COVE) on nine occasions; 4) Use of the NASA Goddard Cloud Absorption Radiometer (CAR) to obtain measurements of BRDF of the ocean surface on fifteen occasions and over Great Dismal Swamp on two occasions; 5) Measurements of aerosol properties over instrumented buoys 44014, 44004, and 41001. 6) On July 17 (a CLAMS 'Golden Day') six aircraft, including the Convair-580 and ER-2, were stacked above the Chesapeake Bay lighthouse under clear skies at the time of the Terra overpass.
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Inter-occurrence times and universal laws in finance, earthquakes and genomes
NASA Astrophysics Data System (ADS)
Tsallis, Constantino
2016-07-01
A plethora of natural, artificial and social systems exist which do not belong to the Boltzmann-Gibbs (BG) statistical-mechanical world, based on the standard additive entropy $S_{BG}$ and its associated exponential BG factor. Frequent behaviors in such complex systems have been shown to be closely related to $q$-statistics instead, based on the nonadditive entropy $S_q$ (with $S_1=S_{BG}$), and its associated $q$-exponential factor which generalizes the usual BG one. In fact, a wide range of phenomena of quite different nature exist which can be described and, in the simplest cases, understood through analytic (and explicit) functions and probability distributions which exhibit some universal features. Universality classes are concomitantly observed which can be characterized through indices such as $q$. We will exhibit here some such cases, namely concerning the distribution of inter-occurrence (or inter-event) times in the areas of finance, earthquakes and genomes.
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Are there laws of genome evolution?
Koonin, Eugene V
2011-08-01
Research in quantitative evolutionary genomics and systems biology led to the discovery of several universal regularities connecting genomic and molecular phenomic variables. These universals include the log-normal distribution of the evolutionary rates of orthologous genes; the power law-like distributions of paralogous family size and node degree in various biological networks; the negative correlation between a gene's sequence evolution rate and expression level; and differential scaling of functional classes of genes with genome size. The universals of genome evolution can be accounted for by simple mathematical models similar to those used in statistical physics, such as the birth-death-innovation model. These models do not explicitly incorporate selection; therefore, the observed universal regularities do not appear to be shaped by selection but rather are emergent properties of gene ensembles. Although a complete physical theory of evolutionary biology is inconceivable, the universals of genome evolution might qualify as "laws of evolutionary genomics" in the same sense "law" is understood in modern physics.
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Sequencing Complex Genomic Regions
Eichler, Evan
2018-02-12
Evan Eichler, Howard Hughes Medical Investigator at the University of Washington, gives the May 28, 2009 keynote speech at the "Sequencing, Finishing, Analysis in the Future" meeting in Santa Fe, NM. Part 1 of 2
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Undergraduate Research at the Research Universities.
ERIC Educational Resources Information Center
Merkel, Carolyn Ash
2003-01-01
Explores four higher education institutions (Rutgers University, the University of Washington, the Massachusetts Institute of Technology, and the California Institute of Technology) and their histories of developing a culture of undergraduate research. (EV)
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Researcher Interview: Elaine Mardis
Elaine Mardis Ph.D., Professor of Medicine at Washington University School of Medicine, discusses her translational research applying genomics techniques to clinical trials, and forecasts the future of team science and cancer genomics.
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RISK FACTORS FOR ENDEMIC GASTROINTESTINAL ILLNESS AMONG A WASHINGTON COHORT
RISK FACTORS FOR ENDEMIC GASTROINTESTINAL ILLNESS AMONG A WASHINGTON COHORT
*Christina A. Peterson 1,2,3 and Rebecca L. Calderon 2
1 Department of Epidemiology
School of Public Health (SPH)
University of North Carolina at Chapel Hill (UNC-CH), 27516
2 Nat... -
Neu, Ursula; Wang, Jianbo; Macejak, Dennis; Garcea, Robert L; Stehle, Thilo
2011-07-01
The Karolinska Institutet and Washington University polyomaviruses (KIPyV and WUPyV, respectively) are recently discovered human viruses that infect the respiratory tract. Although they have not yet been linked to disease, they are prevalent in populations worldwide, with initial infection occurring in early childhood. Polyomavirus capsids consist of 72 pentamers of the major capsid protein viral protein 1 (VP1), which determines antigenicity and receptor specificity. The WUPyV and KIPyV VP1 proteins are distant in evolution from VP1 proteins of known structure such as simian virus 40 or murine polyomavirus. We present here the crystal structures of unassembled recombinant WUPyV and KIPyV VP1 pentamers at resolutions of 2.9 and 2.55 Å, respectively. The WUPyV and KIPyV VP1 core structures fold into the same β-sandwich that is a hallmark of all polyomavirus VP1 proteins crystallized to date. However, differences in sequence translate into profoundly different surface loop structures in KIPyV and WUPyV VP1 proteins. Such loop structures have not been observed for other polyomaviruses, and they provide initial clues about the possible interactions of these viruses with cell surface receptors.
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University of Washington's radioecological studies in the Marshall Islands, 1946-1977.
Donaldson, L R; Seymour, A H; Nevissi, A E
1997-07-01
Since 1946, personnel from the School of Fisheries, University of Washington (Applied Fisheries Laboratory, 1943-1958; Laboratory of Radiation Biology, 1958-1967; and Laboratory of Radiation Ecology, since 1967), have studied the effects of nuclear detonations and the ensuing radioactivity on the marine and terrestrial environments throughout the Central Pacific. A collection of reports and publications about these activities plus a collection of several thousand samples from these periods are kept at the School of Fisheries. General findings from the surveys show that (1) fission products were prevalent in organisms of the terrestrial environment whereas activation products were prevalent in marine organisms; (2) the best biological indicators of fallout radionuclides by environments were (a) terrestrial-coconuts, land crabs; (b) reef-algae, invertebrates; and (c) marine-plankton, fish. Studies of plutonium and americium in Bikini Atoll showed that during 1971-1977 the highest concentrations of 241Am, 2.85 Bq g(-1) (77 pCi g(-1)) and 239,240Pu, 4.44 Bq g(-1) (120 pCi g(-1)), in surface sediments were found in the northwest part of the lagoon. The concentrations in the bomb craters were substantially lower than these values. Concentrations of soluble and particulate plutonium and americium in surface and deep water samples showed distributions similar to the sediment samples. That is, the highest concentration of these radionuclides in the water column were at locations with highest sediment concentration. Continuous circulation of water in the lagoon and exchange of water with open ocean resulted in removal of 111 G Bq y(-1) (3 Ci y(-1)) 241Am and 222 G Bq y(-1) (6 Ci y(-1)) 239,240Pu into the North Equatorial Current. A summary of the surveys, findings, and the historical role of the Laboratory in radioecological studies of the Marshall Islands are presented.
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Federal Register 2010, 2011, 2012, 2013, 2014
2013-03-08
...,372B] Simpson Lumber Company, LLC, Shelton, Washington; Simpson Lumber Company, LLC, Tacoma, Washington; Simpson Lumber Company, LLC, Longview, Washington; Notice of Revised Determination on Reconsideration On... Reconsideration for the workers and former workers of Simpson Lumber Company, LLC, Shelton, Washington (TA-W-81...
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NASA Technical Reports Server (NTRS)
Hall, David M.; Boboltz, David
2013-01-01
This report summarizes the activities of the Washington Correlator for 2012. The Washington Correlator provides up to 80 hours of attended processing per week plus up to 40 hours of unattended operation, primarily supporting Earth Orientation and astrometric observations. In 2012, the major programs supported include the IVS-R4, IVS-INT, APSG, and CRF observing sessions.
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Federal Register 2010, 2011, 2012, 2013, 2014
2011-03-16
..., University of Wisconsin Nuclear Reactor; Notice of Issuance of Environmental Assessment and Finding of No... operation of the University of Wisconsin Nuclear Reactor. This action is necessary to add supplemental... of Nuclear Reactor Regulation, U.S. Nuclear Regulatory Commission, Washington, DC 20555-0001...
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STS129 Visit to Howard University
2010-01-12
STS-129 Mission Specialist Leland Melvin speaks to students at the Howard University Middle School of Math and Science, Tuesday, Jan. 12, 2010, on the campus of Howard University in Washington. Photo Credit: (NASA/Paul E. Alers)
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1975 Washington timber harvest.
J.D. Jr. Lloyd
1977-01-01
In 1975, the Washington timber harvest declined for the 2d year to 6.2 billion board feet, 10 percent below 1974, and the lowest level in 8 years. The decrease, which occurred on almost all ownerships, amounted to 561 million board feet in western Washington and 130 million board feet in eastern Washington.
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University of Victoria Genome British Columbia Proteomics Centre, a leader in proteomic technology development, has partnered with the U.S. National Cancer Institute (NCI) to make targeted proteomic assays accessible to the community through NCI’s CPTAC Assay Portal (https://assays.cancer.gov).
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The fifth International Geological Congress, Washington, 1891
Nelson, C.M.
2006-01-01
The 5th International Geological Congress (IGC), the initial meeting in North America, was the first of the three IGCs that have been held in the United States of America (USA). Of the 538 registrants alive when the 5th IGC convened in Washington, 251 persons, representing fifteen countries, actually attended the meeting. These participants included 173 people from the USA, of whom forty-two represented the US Geological Survey (USGS). Fourteen of the US State geological surveys sent representatives to Washington. Eight participants came from other countries in the Western Hemisphere - Canada (3), Chile (1), Mexico (3), and Peru (1). The sixty-six European geologists and naturalists at the 5th IGC represented Austro-Hungary (3), Belgium (3), Britain (12), France (7), Germany (23), Norway (1), Romania (3), Russia (8), Sweden (4), and Switzerland (2). The USGS and the Columbian College (now the George Washington University) acted as the principal hosts. The American Association for the Advancement of Science and then the Geological Society of America (GSA) met in the Capital immediately before the Congress convened (26 August-1 September 1891). The 5th IGC's formal discussions treated the genetic classification of Pleistocene rocks, the chronological correlation of clastic rocks, and the international standardization of colors, symbols, and names used on geologic maps. The third of those topics continued key debates at the 1st through 4th IGCs. The GSA, the Korean Embassy, the Smithsonian Institution's US National Museum, the USGS, and one of the two Secretaries-General hosted evening receptions. Field excursions examined Paleozoic exposures in New York (18-25 August), Cretaceous-Pleistocene localities along the Potomac River south of Washington (30 August), and classic Precambrian-Pleistocene sequences and structures in the Great Plains, Yellowstone, Rocky Mountains, and Great Basin (2-26 September), with optional trips to the Grand Canyon (19-28 September) and Lake
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STS129 Visit to Howard University
2010-01-12
STS-129 Mission Specialist Leland Melvin speaks to a class room of students at the Howard University Middle School of Math and Science, Tuesday, Jan. 12, 2010, on the campus of Howard University in Washington. Photo Credit: (NASA/Paul E. Alers)
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NASA Technical Reports Server (NTRS)
Klein, Vladislav
2002-01-01
The program objectives were defined in the original proposal entitled 'Program of Research in Flight Dynamics in the JIAFS at NASA Langley Research Center' which was originated March 20, 1975, and yearly renewals of the research program dated December 1, 1998 to December 31, 2002. The program included three major topics: 1) Improvement of existing methods and development of new methods for flight and wind tunnel data analysis based on system identification methodology; 2) Application of these methods to flight and wind tunnel data obtained from advanced aircraft; 3) Modeling and control of aircraft. The principal investigator of the program was Dr. Vladislav Klein, Professor Emeritus at The George Washington University, DC. Seven Graduate Research Scholar Assistants (GRSA) participated in the program. The results of the research conducted during four years of the total co-operative period were published in 2 NASA Technical Reports, 3 thesis and 3 papers. The list of these publications is included.
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Navigating protected genomics data with UCSC Genome Browser in a Box.
Haeussler, Maximilian; Raney, Brian J; Hinrichs, Angie S; Clawson, Hiram; Zweig, Ann S; Karolchik, Donna; Casper, Jonathan; Speir, Matthew L; Haussler, David; Kent, W James
2015-03-01
Genome Browser in a Box (GBiB) is a small virtual machine version of the popular University of California Santa Cruz (UCSC) Genome Browser that can be run on a researcher's own computer. Once GBiB is installed, a standard web browser is used to access the virtual server and add personal data files from the local hard disk. Annotation data are loaded on demand through the Internet from UCSC or can be downloaded to the local computer for faster access. Software downloads and installation instructions are freely available for non-commercial use at https://genome-store.ucsc.edu/. GBiB requires the installation of open-source software VirtualBox, available for all major operating systems, and the UCSC Genome Browser, which is open source and free for non-commercial use. Commercial use of GBiB and the Genome Browser requires a license (http://genome.ucsc.edu/license/). © The Author 2014. Published by Oxford University Press.
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Climate change vulnerability and adaptation in the North Cascades region, Washington
Crystal L. Raymond; David L. Peterson; Regina M. Rochefort
2014-01-01
The North Cascadia Adaptation Partnership (NCAP) is a science-management partnership consisting of the U.S. Department of Agriculture Forest Service Mount Baker-Snoqualmie and Okanogan-Wenatchee National Forests and Pacific Northwest Research Station; North Cascades National Park Complex; Mount Rainier National Park; and University of Washington Climate Impacts Group....
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1967 Washington timber harvest.
Brian R. Wall
1968-01-01
Washington's 1967 timber harvest declined to 5.9 billion board feet, 2.3 percent below the 1966 harvest. The cut on public lands remained about the same as in 1966 with a 6.7-percent increase in public cut in eastern Washington, offsetting a 2.2-percent decrease in western Washington. The Indian lands had the greatest increase in harvest, up 35 million board feet...
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1970 Washington timber harvest.
Brian R. Wall
1971-01-01
Washington's 1970 timber harvest of 6.46 billion board feet was 7.8 percent below the near record harvest of 7 billion board feet established in 1969. Timber harvests on all public lands declined 13 percent with a 9.0-percent reduction in western Washington and a 22.9-percent drop in eastern Washington. State lands led the decline in public production with a 142-...
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75 FR 51239 - University of Massachusetts Amherst, et al.
Federal Register 2010, 2011, 2012, 2013, 2014
2010-08-19
... DEPARTMENT OF COMMERCE International Trade Administration University of Massachusetts Amherst, et... Commerce, 14th and Constitution Avenue., NW., Washington, DC. Docket Number: 10-044. Applicant: University.... Applicant: Appalachian State University, Boone, NC 28608. Instrument: Electron Microscope. Manufacturer...
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Raise Your Voice: Leonard Haynes III Advocates for HBCUs in Washington
ERIC Educational Resources Information Center
Stuart, Reginald
2012-01-01
When Leonard Haynes III came to Washington in 1989 as an assistant secretary of education, the Southern University-trained historian found a national government marked by bipartisanship, collaboration and cooperation on a wide range of topics of importance to people of color in higher education. Today, the landscape and environment are "more…
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76 FR 77775 - University of Florida, et al.;
Federal Register 2010, 2011, 2012, 2013, 2014
2011-12-14
... DEPARTMENT OF COMMERCE International Trade Administration University of Florida, et al.; Notice of... Constitution Avenue NW., Washington, DC. Docket Number: 11-065. Applicant: University of Florida, Gainesville...: See notice at 76 FR 70410, November 14, 2011. Docket Number: 11-066. Applicant: University of Florida...
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Making the Grade: How a Semester in Washington May Influence Future Academic Performance
ERIC Educational Resources Information Center
Lowenthal, Diane J.; Sosland, Jeffrey K.
2007-01-01
By examining American University's Washington Semester Program (AUWSP), this project analyzes the impact of intensive undergraduate experiential and active learning on subsequent student academic performance. In this article, we discuss the differences between traditional, active, and experiential learning methods to better understand the…
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Walking the Talk: Empowering Science Communication at the University of Washington
NASA Astrophysics Data System (ADS)
Meyer, J. J.; Davison, J.; Graumlich, L. J.; McCarthy, M. M.
2016-12-01
Interest is growing within the academy to strengthen scientists' abilities to be better communicators about their research and how connects to society. Yet communicating the complexities of science to external audiences — media, policy-makers, funders, and others — in a way that resonates falls outside the realm of traditional academic training. Many institutions do not provide adequate resources for their faculty, students and staff to build skills to their share their work more broadly. The University of Washington College of the Environment has built a program that breaks down some of these barriers, building capacity for faculty, students and staff to become powerful spokespeople for their work. Leadership within the College values strong science communication skills and is reflected in the College's strategic plan. As a result, the College has built a science communication program that offers numerous services to meet researchers where they are to help amplify the impact of their work. Stemming from the recommendations of a Science Communication Task Force, the College of the Environment focuses on advancing three critical areas: building and connecting networks of science communicators, offering tools and trainings to develop communication skills, and providing opportunity for researchers to share their work outside of academia. These areas are related by 1) connecting researchers to a robust and growing community of their peers interested in science communication, 2) matching interest with the skills needed to engage productively, and 3) helping provide outlets for engagement that align with the goals of the researcher. As a result, more and more scientists in the College are seeking assistance to build this skillset for engagement. Many institutions express support for increasing science communication skills, yet it can be difficult to deliver a suite of cohesive resources. Through a modest investment, we have built a replicable program that not only
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Pugh, Stephanie L.; Wyatt, Gwen; Wong, Raimond K. W.; Sagar, Stephen M.; Yueh, Bevan; Singh, Anurag K.; Yao, Min; Nguyen-Tan, Phuc Felix; Yom, Sue S.; Cardinale, Francis S.; Sultanem, Khalil; Hodson, D. Ian; Krempl, Greg A.; Chavez, Ariel; Yeh, Alexander M.; Bruner, Deborah W.
2016-01-01
Context The 15-item University of Washington Quality of Life questionnaire – Radiation Therapy Oncology Group (RTOG) modification (UW-QOL-RTOG modification) has been used in several trials of head and neck cancer conducted by NRG Oncology such as RTOG 9709, RTOG 9901, RTOG 0244, and RTOG 0537. Objectives This study is an exploratory factor analysis (EFA) to establish validity and reliability of the instrument subscales. Methods EFA on the UW-QOL - RTOG modification was conducted using baseline data from NRG Oncology's RTOG 0537, a trial of acupuncture-like transcutaneous electrical nerve stimulation in treating radiation-induced xerostomia. Cronbach's α coefficient was calculated to measure reliability; correlation with the University of Michigan Xerostomia Related Quality of Life Scale (XeQOLS) was used to evaluate concurrent validity; and correlations between consecutive time points were used to assess test-retest reliability. Results The 15-item EFA of the modified tool resulted in 11 items split into 4 factors: mucus, eating, pain, and activities. Cronbach's α ranged from 0.71 to 0.93 for the factors and total score, consisting of all 11 items. There were strong correlations (ρ≥0.60) between consecutive time points and between total score and the XeQOLS total score (ρ>0.65). Conclusion The UW-QOL-RTOG modification is a valid tool that can be used to assess symptom burden of head and neck cancer patients receiving radiation therapy or those who have recently completed radiation. The modified tool has acceptable reliability, concurrent validity, and test-retest reliability in this patient population, as well as the advantage of having being shortened from 15 to 11 items. PMID:27899312
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12 CFR 4.4 - Washington office.
Code of Federal Regulations, 2010 CFR
2010-01-01
... 12 Banks and Banking 1 2010-01-01 2010-01-01 false Washington office. 4.4 Section 4.4 Banks and... EXAMINERS Organization and Functions § 4.4 Washington office. The Washington office of the OCC is the main office and headquarters of the OCC. The Washington office directs OCC policy, oversees OCC operations...
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Chrzastowski, Michael J.
1983-01-01
Lake Washington, in the midst of the greater Seattle metropolitan area of the Puget Sound region (fig. 1), is an exceptional commercial, recreational, and esthetic resource for the region . In the past 130 years, Lake Washington has been changed from a " wild " lake in a wilderness setting to a regulated lake surrounded by a growing metropolis--a transformation that provides an unusual opportunity to study changes to a lake's shoreline and hydrologic characteristics -resulting from urbanization.
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Goldstein, Erika A; Maclaren, Carol F; Smith, Sherilyn; Mengert, Terry J; Maestas, Ramoncita R; Foy, Hugh M; Wenrich, Marjorie D; Ramsey, Paul G
2005-05-01
The focus on fundamental clinical skills in undergraduate medical education has declined over the last several decades. Dramatic growth in the number of faculty involved in teaching and increasing clinical and research commitments have contributed to depersonalization and declining individual attention to students. In contrast to the close teaching and mentoring relationship between faculty and students 50 years ago, today's medical students may interact with hundreds of faculty members without the benefit of a focused program of teaching and evaluating clinical skills to form the core of their four-year curriculum. Bedside teaching has also declined, which may negatively affect clinical skills development. In response to these and other concerns, the University of Washington School of Medicine has created an integrated developmental curriculum that emphasizes bedside teaching and role modeling, focuses on enhancing fundamental clinical skills and professionalism, and implements these goals via a new administrative structure, the College system, which consists of a core of clinical teachers who spend substantial time teaching and mentoring medical students. Each medical student is assigned a faculty mentor within a College for the duration of his or her medical school career. Mentors continuously teach and reflect with students on clinical skills development and professionalism and, during the second year, work intensively with them at the bedside. They also provide an ongoing personal faculty contact. Competency domains and benchmarks define skill areas in which deepening, progressive attention is focused throughout medical school. This educational model places primary focus on the student.
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Bellman, Scott; Burgstahler, Sheryl; Ladner, Richard
2014-01-01
This case study describes evidence-based practices employed by a collection of University of Washington projects that engage high school and postsecondary students with disabilities in work-based learning experiences such as industry and research internships, career development activities, job shadows, field trips, and mock interviews. The purpose of the article is two-fold. First, authors share best practices with others who wish to increase the participation of students with disabilities in work-based learning and thereby contribute to their academic and career success. The article discusses methods used to recruit students, employers and mentors, match students with specific opportunities, and prepare students for success. Second, authors share outcomes from studies regarding participation in these work-based learning opportunities, which include increased employment success, motivation to work toward a career, knowledge about careers and the workplace, job-related skills, ability to work with supervisors and coworkers, skills in self-advocating for accommodations, and perceived career options.
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Death with dignity in Washington patients with amyotrophic lateral sclerosis
Elliott, Michael A.; Jung Henson, Lily; Gerena-Maldonado, Elba; Strom, Susan; Downing, Sharon; Vetrovs, Jennifer; Kayihan, Paige; Paul, Piper; Kennedy, Kate; Benditt, Joshua O.; Weiss, Michael D.
2016-01-01
Objectives: To describe the amyotrophic lateral sclerosis (ALS) patients who sought medication under the Washington State Death with Dignity (DWD) Act since its inception in 2009. Methods: Chart review at 3 tertiary medical centers in the Seattle/Puget Sound region and comparison to publicly available data of ALS and all-cause DWD cohorts from Washington and Oregon. Results: In Washington State, 39 patients with ALS requested DWD from the University of Washington, Virginia Mason, and Swedish Medical Centers beginning in 2009. The median age at death was 65 years (range 46–86). Seventy-seven percent of the patients used the prescriptions. All of the patients who used the medications passed away without complications. The major reasons for patients to request DWD as reported by participating physicians were loss of autonomy and dignity and decrease in enjoyable activities. Inadequate pain control, financial cost, and loss of bodily control were less commonly indicated. These findings were similar to those of the 92 patients who sought DWD in Oregon. In Washington and Oregon, the percentage of patients with ALS seeking DWD is higher compared to the cancer DWD cohort. Furthermore, compared to the all-cause DWD cohort, patients with ALS are more likely to be non-Hispanic white, married, educated, enrolled in hospice, and to have died at home. Conclusions: Although a small number, ALS represents the disease with the highest proportion of patients seeking to participate in DWD. Patients with ALS who choose DWD are well-educated and have access to palliative or life-prolonging care. The use of the medications appears to be able to achieve the patients' goals without complications. PMID:27770068
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Death with dignity in Washington patients with amyotrophic lateral sclerosis.
Wang, Leo H; Elliott, Michael A; Jung Henson, Lily; Gerena-Maldonado, Elba; Strom, Susan; Downing, Sharon; Vetrovs, Jennifer; Kayihan, Paige; Paul, Piper; Kennedy, Kate; Benditt, Joshua O; Weiss, Michael D
2016-11-15
To describe the amyotrophic lateral sclerosis (ALS) patients who sought medication under the Washington State Death with Dignity (DWD) Act since its inception in 2009. Chart review at 3 tertiary medical centers in the Seattle/Puget Sound region and comparison to publicly available data of ALS and all-cause DWD cohorts from Washington and Oregon. In Washington State, 39 patients with ALS requested DWD from the University of Washington, Virginia Mason, and Swedish Medical Centers beginning in 2009. The median age at death was 65 years (range 46-86). Seventy-seven percent of the patients used the prescriptions. All of the patients who used the medications passed away without complications. The major reasons for patients to request DWD as reported by participating physicians were loss of autonomy and dignity and decrease in enjoyable activities. Inadequate pain control, financial cost, and loss of bodily control were less commonly indicated. These findings were similar to those of the 92 patients who sought DWD in Oregon. In Washington and Oregon, the percentage of patients with ALS seeking DWD is higher compared to the cancer DWD cohort. Furthermore, compared to the all-cause DWD cohort, patients with ALS are more likely to be non-Hispanic white, married, educated, enrolled in hospice, and to have died at home. Although a small number, ALS represents the disease with the highest proportion of patients seeking to participate in DWD. Patients with ALS who choose DWD are well-educated and have access to palliative or life-prolonging care. The use of the medications appears to be able to achieve the patients' goals without complications. © 2016 American Academy of Neurology.
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Structural genomics: keeping up with expanding knowledge of the protein universe.
Grabowski, Marek; Joachimiak, Andrzej; Otwinowski, Zbyszek; Minor, Wladek
2007-06-01
Structural characterization of the protein universe is the main mission of Structural Genomics (SG) programs. However, progress in gene sequencing technology, set in motion in the 1990s, has resulted in rapid expansion of protein sequence space--a twelvefold increase in the past seven years. For the SG field, this creates new challenges and necessitates a re-assessment of its strategies. Nevertheless, despite the growth of sequence space, at present nearly half of the content of the Swiss-Prot database and over 40% of Pfam protein families can be structurally modeled based on structures determined so far, with SG projects making an increasingly significant contribution. The SG contribution of new Pfam structures nearly doubled from 27.2% in 2003 to 51.6% in 2006.
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Structural genomics: keeping up with expanding knowledge of the protein universe
Grabowski, Marek; Joachimiak, Andrzej; Otwinowski, Zbyszek; Minor, Wladek
2010-01-01
Structural characterization of the protein universe is the main mission of Structural Genomics (SG) programs. However, progress in gene sequencing technology, set in motion in the 1990s, has resulted in rapid expansion of protein sequence space — a twelvefold increase in the past seven years. For the SG field, this creates new challenges and necessitates a reassessment of its strategies. Nevertheless, despite the growth of sequence space, at present nearly half of the content of the Swiss-Prot database and over 40% of Pfam protein families can be structurally modeled based on structures determined so far, with SG projects making an increasingly significant contribution. The SG contribution of new Pfam structures nearly doubled from 27.2% in 2003 to 51.6% in 2006. PMID:17587562
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Forest industries of eastern Washington.
Brian R. Wall; Donald R. Gedney; Robert B. Forster
1966-01-01
A sawmill, built in 1872, marked the beginning of the forest industry in eastern Washington -- almost half a century after the emergence of the lumber industry in western Washington. Since then, this industry has increased in importance to eastern Washington's economy, now furnishing about one-fifth of the total manufacturing employment and wages paidin...
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Ensembl Genomes 2016: more genomes, more complexity.
Kersey, Paul Julian; Allen, James E; Armean, Irina; Boddu, Sanjay; Bolt, Bruce J; Carvalho-Silva, Denise; Christensen, Mikkel; Davis, Paul; Falin, Lee J; Grabmueller, Christoph; Humphrey, Jay; Kerhornou, Arnaud; Khobova, Julia; Aranganathan, Naveen K; Langridge, Nicholas; Lowy, Ernesto; McDowall, Mark D; Maheswari, Uma; Nuhn, Michael; Ong, Chuang Kee; Overduin, Bert; Paulini, Michael; Pedro, Helder; Perry, Emily; Spudich, Giulietta; Tapanari, Electra; Walts, Brandon; Williams, Gareth; Tello-Ruiz, Marcela; Stein, Joshua; Wei, Sharon; Ware, Doreen; Bolser, Daniel M; Howe, Kevin L; Kulesha, Eugene; Lawson, Daniel; Maslen, Gareth; Staines, Daniel M
2016-01-04
Ensembl Genomes (http://www.ensemblgenomes.org) is an integrating resource for genome-scale data from non-vertebrate species, complementing the resources for vertebrate genomics developed in the context of the Ensembl project (http://www.ensembl.org). Together, the two resources provide a consistent set of programmatic and interactive interfaces to a rich range of data including reference sequence, gene models, transcriptional data, genetic variation and comparative analysis. This paper provides an update to the previous publications about the resource, with a focus on recent developments. These include the development of new analyses and views to represent polyploid genomes (of which bread wheat is the primary exemplar); and the continued up-scaling of the resource, which now includes over 23 000 bacterial genomes, 400 fungal genomes and 100 protist genomes, in addition to 55 genomes from invertebrate metazoa and 39 genomes from plants. This dramatic increase in the number of included genomes is one part of a broader effort to automate the integration of archival data (genome sequence, but also associated RNA sequence data and variant calls) within the context of reference genomes and make it available through the Ensembl user interfaces. © The Author(s) 2015. Published by Oxford University Press on behalf of Nucleic Acids Research.
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STS129 Visit to Howard University
2010-01-12
STS-129 Mission Specialist Leland Melvin, left. looks on as Mission Specialist Robert Satcher answers a question during a presentation to students at the Howard University Middle School of Math and Science, Tuesday, Jan. 12, 2010, on the campus of Howard University in Washington. Photo Credit: (NASA/Paul E. Alers)
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De León, Kara B.; Utturkar, Sagar M.; Camilleri, Laura B.; ...
2015-09-24
The genome of Pelosinus fermentans JBW45, isolated from a chromium-contaminated site in Hanford, Washington, USA, has been completed with PacBio sequencing. Finally, nine copies of the rRNA gene operon and multiple transposase genes with identical sequences resulted in breaks in the original draft genome and may suggest genomic instability of JBW45.
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Comparison of Recalled and Prospectively Collected Gastrointestinal Symptom Data Within a Washington Cohort.
Christina A. Peterson1,2,3; James C. Thomas 1; Twila K. Kunde4; Rebecca L. Calderon2
1 Department of Epidemiology, University of North Carolina at Chapel Hill -
Haemonchus contortus: Genome Structure, Organization and Comparative Genomics.
Laing, R; Martinelli, A; Tracey, A; Holroyd, N; Gilleard, J S; Cotton, J A
2016-01-01
One of the first genome sequencing projects for a parasitic nematode was that for Haemonchus contortus. The open access data from the Wellcome Trust Sanger Institute provided a valuable early resource for the research community, particularly for the identification of specific genes and genetic markers. Later, a second sequencing project was initiated by the University of Melbourne, and the two draft genome sequences for H. contortus were published back-to-back in 2013. There is a pressing need for long-range genomic information for genetic mapping, population genetics and functional genomic studies, so we are continuing to improve the Wellcome Trust Sanger Institute assembly to provide a finished reference genome for H. contortus. This review describes this process, compares the H. contortus genome assemblies with draft genomes from other members of the strongylid group and discusses future directions for parasite genomics using the H. contortus model. Copyright © 2016 Elsevier Ltd. All rights reserved.
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POTENTIAL IMPACTS OF GENOMICS ON EPA REGULATORY AND RISK ASSESSMENT APPLICATIONS
Gallagher, Kathryn and William Benson. In press. Potential Impacts of Genomics on EPA Regulatory and Risk Assessment (Abstract). To be presented at the EPA Science Forum: Healthy Communities and Ecosystems, 1-3 June 2004, Washington, DC. 1 p. (ERL,GB R991).
Advances in ge... -
The 50th anniversary of long-term hemodialysis: University of Washington Hospital, March 9th, 1960.
Blagg, Christopher R
2011-01-01
The first 6 months of 1960 saw the development of the shunt that first made long-term hemodialysis possible for patients dying from chronic kidney failure. A brief account of hemodialysis for acute kidney failure prior to 1960 is followed by a description of the work of Belding Scribner, Wayne Quinton and David Dillard at the University of Washington in Seattle. Scribner had the idea of a shunt connecting indwelling arterial and venous cannulas in the forearm between dialyses, to maintain patency of the cannulas, Quinton used Teflon tubing to make the device, and Dillard was the surgeon who implanted the first shunt on March 9th, 1960. The patient, Clyde Shields, was a 39-year-old man dying from uremia secondary to chronic glomerulonephritis. The shunt worked, and Clyde lived a further 11 years on dialysis. Scribner took Quinton and Clyde to the American Society for Artificial Internal Organs (ASAIO) meeting in April and showed Clyde to physicians interested in dialysis, and Quinton demonstrated fabrication of the shunt. In June 1960, 2 landmark papers describing cannulation and the treatment were published in the Transactions of the ASAIO. Today there are some 2 million patients with end-stage renal disease living worldwide.
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GenomeD3Plot: a library for rich, interactive visualizations of genomic data in web applications.
Laird, Matthew R; Langille, Morgan G I; Brinkman, Fiona S L
2015-10-15
A simple static image of genomes and associated metadata is very limiting, as researchers expect rich, interactive tools similar to the web applications found in the post-Web 2.0 world. GenomeD3Plot is a light weight visualization library written in javascript using the D3 library. GenomeD3Plot provides a rich API to allow the rapid visualization of complex genomic data using a convenient standards based JSON configuration file. When integrated into existing web services GenomeD3Plot allows researchers to interact with data, dynamically alter the view, or even resize or reposition the visualization in their browser window. In addition GenomeD3Plot has built in functionality to export any resulting genome visualization in PNG or SVG format for easy inclusion in manuscripts or presentations. GenomeD3Plot is being utilized in the recently released Islandviewer 3 (www.pathogenomics.sfu.ca/islandviewer/) to visualize predicted genomic islands with other genome annotation data. However, its features enable it to be more widely applicable for dynamic visualization of genomic data in general. GenomeD3Plot is licensed under the GNU-GPL v3 at https://github.com/brinkmanlab/GenomeD3Plot/. brinkman@sfu.ca. © The Author 2015. Published by Oxford University Press.
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An Inventory of Library Services and Resources of the State of Washington, 1965.
ERIC Educational Resources Information Center
Bevis, L. Dorothy
This survey of current library resources and services in Washington is based on questionnaires; visits to public, university, college and community college libraries in the state; and statistics from state and national governmental sources. The inventories of public and academic libraries include discussions of standards applicable to the…
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Better Jobs, Brighter Futures, a Stronger Washington. Washington's Community and Technical Colleges
ERIC Educational Resources Information Center
Washington State Board for Community and Technical Colleges, 2015
2015-01-01
The world is changing rapidly. With changes in technology, demographics, and workforce trends, Washington needs colleges to not only keep pace, but lead the way. Washington's 34 community and technical colleges answer that call. The community and technical colleges have proven uniquely positioned to adapt to, embrace, and ignite change. Community…
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ERIC Educational Resources Information Center
Smallwood, Scott
2001-01-01
Describes the breach-of-contract lawsuit brought by former faculty members at Mount Vernon College, Washington, DC, as a result of the takeover of the small college for women by George Washington University, which resulted in the closing of Mount Vernon and the dismissal of its faculty. (SLD)
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ERIC Educational Resources Information Center
Clark, Stephanie; McCurdy, Alan; Roy, Sharon; Smith, Denise
2006-01-01
Thirty-two recent graduates from the joint food science program of Washington State Univ. (WSU) and The Univ. of Idaho (UI) and 12 of their employers participated in a survey study to assess food science program outcomes. The objective of this study was to assess the joint curriculum in its ability to prepare undergraduate students for critical…
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Experiential Learning for Native American Students at Tribal Colleges and Universities
NASA Astrophysics Data System (ADS)
Sauve, M. L.; Moore, K.
2003-12-01
In reaffirming its commitment to Indian tribes and Alaska Native entities, the Federal Government issued Executive Order 13270 of July 3, 2002, stating the policy that " this Nation's commitment to education excellence and opportunity must extend as well to the tribal colleges and universities." Further, the Federal Government has called on the private sector to contribute to these colleges' educational and cultural mission. American University, through its American Indian Internship Program, has responded to this call. American University, a private liberal arts institution of higher education in the Nation's capital, has long ago recognized the importance of experiential learning in undergraduate education. For over 50 years, its Washington Semester Program brings students from other universities around the country and the world to American University's campus and to Washington, D.C. for a unique academic experience. The Washington Semester Program combines academic seminars in various fields of concentration with internship work in government agencies, congressional offices, non-profit organizations, foundations and research institutions in the Nation's capital. Students in this Program get to meet the Nation's leaders, experts in the field, and notable newsmakers while incorporating their academic skills and courses in practice at their internship assignments. The American Indian Internship Program (also knows as Washington Internship for Native Students-WINS) is one of the programs in Washington Semester. This program is designed to give American Indian students the chance to study issues of interest to the Native community and to gain valuable work experience through an internship in the Nation's capital. All costs to attend the program are paid by the internship sponsors and American University, including transportation between the students' home and Washington, DC, tuition and program fees for 6 credit hours in the summer and 12 credit hours in fall
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Hymenoptera Genome Database: integrating genome annotations in HymenopteraMine.
Elsik, Christine G; Tayal, Aditi; Diesh, Colin M; Unni, Deepak R; Emery, Marianne L; Nguyen, Hung N; Hagen, Darren E
2016-01-04
We report an update of the Hymenoptera Genome Database (HGD) (http://HymenopteraGenome.org), a model organism database for insect species of the order Hymenoptera (ants, bees and wasps). HGD maintains genomic data for 9 bee species, 10 ant species and 1 wasp, including the versions of genome and annotation data sets published by the genome sequencing consortiums and those provided by NCBI. A new data-mining warehouse, HymenopteraMine, based on the InterMine data warehousing system, integrates the genome data with data from external sources and facilitates cross-species analyses based on orthology. New genome browsers and annotation tools based on JBrowse/WebApollo provide easy genome navigation, and viewing of high throughput sequence data sets and can be used for collaborative genome annotation. All of the genomes and annotation data sets are combined into a single BLAST server that allows users to select and combine sequence data sets to search. © The Author(s) 2015. Published by Oxford University Press on behalf of Nucleic Acids Research.
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Washington, D.C. - Local Information | NREL
International Airport (IAD), and Baltimore/Washington International Thurgood Marshall Airport (BWI). DCA is the additional information. Reagan National Airport - DCA Dulles International Airport - IAD Baltimore/Washington International Thurgood Marshall Airport - BWI Public Transportation The Washington Metropolitan Area Transit
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Analysis of Price Changes in Washington Following the 2012 Liquor Privatization.
Kerr, William C; Williams, Edwina; Greenfield, Thomas K
2015-11-01
In June, 2012 the state of Washington ended a wholesale and retail monopoly on liquor sales resulting in about five times as many stores selling liquor. Three-tier restrictions were also removed on liquor, while beer and wine availability did not increase. Substantial taxes at both the wholesale and retail levels were implemented and it was expected that prices would rise. To evaluate price changes after privatization we developed an index of about 68 brands that were popular in Washington during early 2012. Data on final liquor prices (including all taxes) in Washington were obtained through store visits and on-line sources between November 2013 and March of 2014. Primary analyses were conducted on five or six brand indexes to allow the inclusion of most stores. Washington liquor prices rose by an average of 15.5% for the 750 ml size and by 4.7% for the 1.75 l size, while only small changes were seen in the bordering states of Oregon and Idaho. Prices were found to vary greatly by store type. Liquor Superstores had generally the lowest prices while drugstore, grocery and especially smaller Liquor Store prices were found to be substantially higher. Our findings indicate that liquor prices in Washington increased substantially after privatization and as compared to price changes in bordering states, with a much larger increase seen for the 750 ml size and with wide variation across store types. However, persistent drinkers looking for low prices will be able to find them in certain stores. © The Author 2015. Medical Council on Alcohol and Oxford University Press. All rights reserved.
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The Genomic Data Commons (GDC), a unified data system that promotes sharing of genomic and clinical data between researchers, launched today with a visit from Vice President Joe Biden to the operations center at the University of Chicago.
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A Thousand Fly Genomes: An Expanded Drosophila Genome Nexus.
Lack, Justin B; Lange, Jeremy D; Tang, Alison D; Corbett-Detig, Russell B; Pool, John E
2016-12-01
The Drosophila Genome Nexus is a population genomic resource that provides D. melanogaster genomes from multiple sources. To facilitate comparisons across data sets, genomes are aligned using a common reference alignment pipeline which involves two rounds of mapping. Regions of residual heterozygosity, identity-by-descent, and recent population admixture are annotated to enable data filtering based on the user's needs. Here, we present a significant expansion of the Drosophila Genome Nexus, which brings the current data object to a total of 1,121 wild-derived genomes. New additions include 305 previously unpublished genomes from inbred lines representing six population samples in Egypt, Ethiopia, France, and South Africa, along with another 193 genomes added from recently-published data sets. We also provide an aligned D. simulans genome to facilitate divergence comparisons. This improved resource will broaden the range of population genomic questions that can addressed from multi-population allele frequencies and haplotypes in this model species. The larger set of genomes will also enhance the discovery of functionally relevant natural variation that exists within and between populations. © The Author 2016. Published by Oxford University Press on behalf of the Society for Molecular Biology and Evolution.
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Booker T. Washington Rediscovered
ERIC Educational Resources Information Center
Bieze, Michael Scott, Ed.; Gasman, Marybeth, Ed.
2012-01-01
Booker T. Washington, a founding father of African American education in the United States, has long been studied, revered, and reviled by scholars and students. Born into slavery, freed and raised in the Reconstruction South, and active in educational reform through the late nineteenth and early twentieth centuries, Washington sought to use…
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Howard University Hospital finds partner in helping children succeed.
Botvin, Judith D
2005-01-01
Howard University Hospital, Washington, D.C., becomes the site for the launch of a national ad campaign by the nonprofit youth education organization, Communities in Schools. The hospital and university share the organization's mission of supporting young people in the community.
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Friedberg, Mark W; Martsolf, Grant R; White, Chapin; Auerbach, David I; Kandrack, Ryan; Reid, Rachel O; Butcher, Emily; Yu, Hao; Hollands, Simon; Nie, Xiaoyu
2017-01-01
The Washington State legislature has recently considered several policy options to address a perceived shortage of primary care physicians in rural Washington. These policy options include opening the new Elson S. Floyd College of Medicine at Washington State University in 2017; increasing the number of primary care residency positions in the state; expanding educational loan-repayment incentives to encourage primary care physicians to practice in rural Washington; increasing Medicaid payment rates for primary care physicians in rural Washington; and encouraging the adoption of alternative models of primary care, such as medical homes and nurse-managed health centers, that reallocate work from physicians to nurse practitioners (NPs) and physician assistants (PAs). RAND Corporation researchers projected the effects that these and other policy options could have on the state's rural primary care workforce through 2025. They project a 7-percent decrease in the number of rural primary care physicians and a 5-percent decrease in the number of urban ones. None of the policy options modeled in this study, on its own, will offset this expected decrease by relying on physicians alone. However, combinations of these strategies or partial reallocation of rural primary care services to NPs and PAs via such new practice models as medical homes and nurse-managed health centers are plausible options for preserving the overall availability of primary care services in rural Washington through 2025.
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Litvintseva, Anastasia P.; Marsden-Haug, Nicola; Hurst, Steven; Hill, Heather; Gade, Lalitha; Driebe, Elizabeth M.; Ralston, Cindy; Roe, Chandler; Barker, Bridget M.; Goldoft, Marcia; Keim, Paul; Wohrle, Ron; Thompson, George R.; Engelthaler, David M.; Brandt, Mary E.; Chiller, Tom
2015-01-01
We used real-time polymerase chain reaction and culture to demonstrate persistent colonization of soils by Coccidioides immitis, an agent of valley fever, in Washington State linked to recent human infections and located outside the endemic range. Whole-genome sequencing confirmed genetic identity between isolates from soil and one of the case-patients. PMID:25165087
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1969 Washington timber harvest.
Brian R. Wall
1970-01-01
Washington's timber harvest increased slightly in 1969 to a 40-year high of 7 billion board feet. This is slightly below the record timber harvest of 7.38 billion board feet established in 1829. Private timberland owners in western Washington increased their production 10.9 percent, accounting for most of the increase in the 1969 total harvest. In eastern...
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DOE Office of Scientific and Technical Information (OSTI.GOV)
NONE
1995-03-01
The DOE proposes to authorize Washington State University (WSU) to proceed with the detailed design, construction, and equipping of the proposed Center for Advanced Industrial Processes (CAIP). The proposed project would involve construction of a three story building containing laboratories, classrooms, seminar rooms, and graduate student and administrative office space. Existing buildings would be demolished. The proposed facility would house research in thermal/fluid sciences, bioengineering, manufacturing processes, and materials processing. Under the {open_quotes}no-action{close_quotes} DOE would not authorize WSU to proceed with construction under the grant. WSU would then need to consider alternatives for proceeding without DOE funds. Such alternatives (includingmore » delaying or scaling back the project), would result in a postponement or slight reduction in the minor adverse environmental, safety and health Impacts of the project evaluated in this assessment. More importantly, these alternatives would affect the important environmental, safety, health, and programmatic benefits of the projects. The surrounding area is fully urbanized and the campus is intensely developed around the proposed site. The buildings scheduled for demolition do not meet State energy codes, are not air conditioned, and lack handicapped access. Sensitive resources (historical/archeological, protected species/critical habitats, wetlands/floodplains, national forests/parks/trails, prime farmland and special sources of water) would not be affected as they do not occur on or near the proposed site. Cumulative impacts would be small. The proposed action is not related to other actions being considered under other NEPA reviews. There is no conflict between the proposed action and any applicable Federal, State, regional or local land use plans and policies.« less
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Navigating yeast genome maintenance with functional genomics.
Measday, Vivien; Stirling, Peter C
2016-03-01
Maintenance of genome integrity is a fundamental requirement of all organisms. To address this, organisms have evolved extremely faithful modes of replication, DNA repair and chromosome segregation to combat the deleterious effects of an unstable genome. Nonetheless, a small amount of genome instability is the driver of evolutionary change and adaptation, and thus a low level of instability is permitted in populations. While defects in genome maintenance almost invariably reduce fitness in the short term, they can create an environment where beneficial mutations are more likely to occur. The importance of this fact is clearest in the development of human cancer, where genome instability is a well-established enabling characteristic of carcinogenesis. This raises the crucial question: what are the cellular pathways that promote genome maintenance and what are their mechanisms? Work in model organisms, in particular the yeast Saccharomyces cerevisiae, has provided the global foundations of genome maintenance mechanisms in eukaryotes. The development of pioneering genomic tools inS. cerevisiae, such as the systematic creation of mutants in all nonessential and essential genes, has enabled whole-genome approaches to identifying genes with roles in genome maintenance. Here, we review the extensive whole-genome approaches taken in yeast, with an emphasis on functional genomic screens, to understand the genetic basis of genome instability, highlighting a range of genetic and cytological screening modalities. By revealing the biological pathways and processes regulating genome integrity, these analyses contribute to the systems-level map of the yeast cell and inform studies of human disease, especially cancer. © The Author 2015. Published by Oxford University Press. All rights reserved. For permissions, please email: journals.permissions@oup.com.
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Burbacher, Thomas M.; Grant, Kimberly S.; Worlein, Julie; Ha, James; Curnow, Eliza; Juul, Sandra; Sackett, Gene P.
2017-01-01
The Infant Primate Research Laboratory (IPRL) was established in the 1970s at the University of Washington as a visionary project of Dr. Gene (Jim) P. Sackett. Supported by a collaboration between the Washington National Primate Research Center and the Center on Human Health and Disability, the IPRL operates under the principle that learning more about the causes of abnormal development in macaque monkeys will provide important insights into mechanisms underlying childhood neurodevelopmental disorders. Over the past forty years, a broad range of research projects have been conducted at the IPRL. Some have described the normal expression of species-typical behaviors in nursery-reared macaques while others have focused on specific issues in perinatal medicine and research. This article will review the unique history of the IPRL and the scientific contributions produced by research conducted in the laboratory. Past and present investigations at the IPRL have explored the consequences of adverse early rearing, low-birth-weight, prematurity, epilepsy, chemical/drug exposure, viral infection, diarrheal disease, vaccine safety, assisted reproductive technologies and perinatal hypoxia on growth and development. New directions of investigation include the production of a transgenic primate model using our embryonic stem cell-based technology to better understand and treat heritable forms of human mental retardation such as fragile X. PMID:23873400
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77 FR 25590 - Drawbridge Operation Regulation; Lake Washington Ship Canal, Seattle, WA
Federal Register 2010, 2011, 2012, 2013, 2014
2012-05-01
...The Coast Guard has issued a temporary deviation from the operating schedule that governs University Bridge across the Lake Washington Ship Canal, mile 4.3, at Seattle, WA. This deviation is necessary to accommodate the Beat the Bridge charity foot race scheduled for Sunday, May 20, 2012. This deviation allows the bridge to remain in the closed position to allow safe movement of event participants.
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DOE Office of Scientific and Technical Information (OSTI.GOV)
Reeve, Wayne
2013-03-01
Wayne Reeve of Murdoch University on "Genomics Encyclopedia of Bacteria and Archaea-Root Nodule Bacteria (GEBA-RNB): a resource for microsymbiont genomes" at the 8th Annual Genomics of Energy & Environment Meeting on March 27, 2013 in Walnut Creek, Calif.
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Dosimetric characteristics of the University of Washington Clinical Neutron Therapy System
NASA Astrophysics Data System (ADS)
Moffitt, Gregory B.; Stewart, Robert D.; Sandison, George A.; Goorley, John T.; Argento, David C.; Jevremovic, Tatjana; Emery, Robert; Wootton, Landon S.; Parvathaneni, Upendra; Laramore, George E.
2018-05-01
The University of Washington (UW) Clinical Neutron Therapy System (CNTS), which generates high linear energy transfer fast neutrons through interactions of 50.5 MeV protons incident on a Be target, has depth-dose characteristics similar to 6 MV x-rays. In contrast to the fixed beam angles and primitive blocking used in early clinical trials of neutron therapy, the CNTS has a gantry with a full 360° of rotation, internal wedges, and a multi-leaf collimator (MLC). Since October of 1984, over 3178 patients have received conformal neutron therapy treatments using the UW CNTS. In this work, the physical and dosimetric characteristics of the CNTS are documented through comparisons of measurements and Monte Carlo simulations. A high resolution computed tomography scan of the model 17 ionization chamber (IC-17) has also been used to improve the accuracy of simulations of the absolute calibration geometry. The response of the IC-17 approximates well the kinetic energy released per unit mass (KERMA) in water for neutrons and photons for energies from a few tens of keV up to about 20 MeV. Above 20 MeV, the simulated model 17 ion chamber response is 20%–30% higher than the neutron KERMA in water. For CNTS neutrons, simulated on- and off-axis output factors in water match measured values within ~2% ± 2% for rectangular and irregularly shaped field with equivalent square areas ranging in a side dimension from 2.8 cm to 30.7 cm. Wedge factors vary by less than 1.9% of the measured dose in water for clinically relevant field sizes. Simulated tissue maximum ratios in water match measured values within 3.3% at depths up to 20 cm. Although the absorbed dose for water and adipose tissue are within 2% at a depth of 1.7 cm, the absorbed dose in muscle and bone can be as much as 12 to 40% lower than the absorbed dose in water. The reported studies are significant from a historical perspective and as additional validation of a new tool for patient quality assurance
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Mr. Smith Goes to Washington: A Resource for Examining Ethical Leadership in Decision-Making.
ERIC Educational Resources Information Center
Pruitt, Randall P.
One of the challenges of a communication instructor is how to initiate the discussion of ethics in the university classroom. The classic film, "Mr. Smith Goes to Washington," has proved a useful tool for initiating discussion of ethical decision-making in leadership. This film presents a young and idealistic leader of boy ranger clubs…
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Integrated genome browser: visual analytics platform for genomics.
Freese, Nowlan H; Norris, David C; Loraine, Ann E
2016-07-15
Genome browsers that support fast navigation through vast datasets and provide interactive visual analytics functions can help scientists achieve deeper insight into biological systems. Toward this end, we developed Integrated Genome Browser (IGB), a highly configurable, interactive and fast open source desktop genome browser. Here we describe multiple updates to IGB, including all-new capabilities to display and interact with data from high-throughput sequencing experiments. To demonstrate, we describe example visualizations and analyses of datasets from RNA-Seq, ChIP-Seq and bisulfite sequencing experiments. Understanding results from genome-scale experiments requires viewing the data in the context of reference genome annotations and other related datasets. To facilitate this, we enhanced IGB's ability to consume data from diverse sources, including Galaxy, Distributed Annotation and IGB-specific Quickload servers. To support future visualization needs as new genome-scale assays enter wide use, we transformed the IGB codebase into a modular, extensible platform for developers to create and deploy all-new visualizations of genomic data. IGB is open source and is freely available from http://bioviz.org/igb aloraine@uncc.edu. © The Author 2016. Published by Oxford University Press.
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Genomic Data Commons launches - TCGA
The Genomic Data Commons (GDC), a unified data system that promotes sharing of genomic and clinical data between researchers, launched today with a visit from Vice President Joe Biden to the operations center at the University of Chicago.
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Family genome browser: visualizing genomes with pedigree information.
Juan, Liran; Liu, Yongzhuang; Wang, Yongtian; Teng, Mingxiang; Zang, Tianyi; Wang, Yadong
2015-07-15
Families with inherited diseases are widely used in Mendelian/complex disease studies. Owing to the advances in high-throughput sequencing technologies, family genome sequencing becomes more and more prevalent. Visualizing family genomes can greatly facilitate human genetics studies and personalized medicine. However, due to the complex genetic relationships and high similarities among genomes of consanguineous family members, family genomes are difficult to be visualized in traditional genome visualization framework. How to visualize the family genome variants and their functions with integrated pedigree information remains a critical challenge. We developed the Family Genome Browser (FGB) to provide comprehensive analysis and visualization for family genomes. The FGB can visualize family genomes in both individual level and variant level effectively, through integrating genome data with pedigree information. Family genome analysis, including determination of parental origin of the variants, detection of de novo mutations, identification of potential recombination events and identical-by-decent segments, etc., can be performed flexibly. Diverse annotations for the family genome variants, such as dbSNP memberships, linkage disequilibriums, genes, variant effects, potential phenotypes, etc., are illustrated as well. Moreover, the FGB can automatically search de novo mutations and compound heterozygous variants for a selected individual, and guide investigators to find high-risk genes with flexible navigation options. These features enable users to investigate and understand family genomes intuitively and systematically. The FGB is available at http://mlg.hit.edu.cn/FGB/. © The Author 2015. Published by Oxford University Press. All rights reserved. For Permissions, please e-mail: journals.permissions@oup.com.
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The founding charter of the Genomic Observatories Network.
Davies, Neil; Field, Dawn; Amaral-Zettler, Linda; Clark, Melody S; Deck, John; Drummond, Alexei; Faith, Daniel P; Geller, Jonathan; Gilbert, Jack; Glöckner, Frank Oliver; Hirsch, Penny R; Leong, Jo-Ann; Meyer, Chris; Obst, Matthias; Planes, Serge; Scholin, Chris; Vogler, Alfried P; Gates, Ruth D; Toonen, Rob; Berteaux-Lecellier, Véronique; Barbier, Michèle; Barker, Katherine; Bertilsson, Stefan; Bicak, Mesude; Bietz, Matthew J; Bobe, Jason; Bodrossy, Levente; Borja, Angel; Coddington, Jonathan; Fuhrman, Jed; Gerdts, Gunnar; Gillespie, Rosemary; Goodwin, Kelly; Hanson, Paul C; Hero, Jean-Marc; Hoekman, David; Jansson, Janet; Jeanthon, Christian; Kao, Rebecca; Klindworth, Anna; Knight, Rob; Kottmann, Renzo; Koo, Michelle S; Kotoulas, Georgios; Lowe, Andrew J; Marteinsson, Viggó Thór; Meyer, Folker; Morrison, Norman; Myrold, David D; Pafilis, Evangelos; Parker, Stephanie; Parnell, John Jacob; Polymenakou, Paraskevi N; Ratnasingham, Sujeevan; Roderick, George K; Rodriguez-Ezpeleta, Naiara; Schonrogge, Karsten; Simon, Nathalie; Valette-Silver, Nathalie J; Springer, Yuri P; Stone, Graham N; Stones-Havas, Steve; Sansone, Susanna-Assunta; Thibault, Kate M; Wecker, Patricia; Wichels, Antje; Wooley, John C; Yahara, Tetsukazu; Zingone, Adriana
2014-03-07
The co-authors of this paper hereby state their intention to work together to launch the Genomic Observatories Network (GOs Network) for which this document will serve as its Founding Charter. We define a Genomic Observatory as an ecosystem and/or site subject to long-term scientific research, including (but not limited to) the sustained study of genomic biodiversity from single-celled microbes to multicellular organisms.An international group of 64 scientists first published the call for a global network of Genomic Observatories in January 2012. The vision for such a network was expanded in a subsequent paper and developed over a series of meetings in Bremen (Germany), Shenzhen (China), Moorea (French Polynesia), Oxford (UK), Pacific Grove (California, USA), Washington (DC, USA), and London (UK). While this community-building process continues, here we express our mutual intent to establish the GOs Network formally, and to describe our shared vision for its future. The views expressed here are ours alone as individual scientists, and do not necessarily represent those of the institutions with which we are affiliated.
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The founding charter of the Genomic Observatories Network
2014-01-01
The co-authors of this paper hereby state their intention to work together to launch the Genomic Observatories Network (GOs Network) for which this document will serve as its Founding Charter. We define a Genomic Observatory as an ecosystem and/or site subject to long-term scientific research, including (but not limited to) the sustained study of genomic biodiversity from single-celled microbes to multicellular organisms. An international group of 64 scientists first published the call for a global network of Genomic Observatories in January 2012. The vision for such a network was expanded in a subsequent paper and developed over a series of meetings in Bremen (Germany), Shenzhen (China), Moorea (French Polynesia), Oxford (UK), Pacific Grove (California, USA), Washington (DC, USA), and London (UK). While this community-building process continues, here we express our mutual intent to establish the GOs Network formally, and to describe our shared vision for its future. The views expressed here are ours alone as individual scientists, and do not necessarily represent those of the institutions with which we are affiliated. PMID:24606731
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The emerging genomics and systems biology research lead to systems genomics studies.
Yang, Mary Qu; Yoshigoe, Kenji; Yang, William; Tong, Weida; Qin, Xiang; Dunker, A; Chen, Zhongxue; Arbania, Hamid R; Liu, Jun S; Niemierko, Andrzej; Yang, Jack Y
2014-01-01
Synergistically integrating multi-layer genomic data at systems level not only can lead to deeper insights into the molecular mechanisms related to disease initiation and progression, but also can guide pathway-based biomarker and drug target identification. With the advent of high-throughput next-generation sequencing technologies, sequencing both DNA and RNA has generated multi-layer genomic data that can provide DNA polymorphism, non-coding RNA, messenger RNA, gene expression, isoform and alternative splicing information. Systems biology on the other hand studies complex biological systems, particularly systematic study of complex molecular interactions within specific cells or organisms. Genomics and molecular systems biology can be merged into the study of genomic profiles and implicated biological functions at cellular or organism level. The prospectively emerging field can be referred to as systems genomics or genomic systems biology. The Mid-South Bioinformatics Centre (MBC) and Joint Bioinformatics Ph.D. Program of University of Arkansas at Little Rock and University of Arkansas for Medical Sciences are particularly interested in promoting education and research advancement in this prospectively emerging field. Based on past investigations and research outcomes, MBC is further utilizing differential gene and isoform/exon expression from RNA-seq and co-regulation from the ChiP-seq specific for different phenotypes in combination with protein-protein interactions, and protein-DNA interactions to construct high-level gene networks for an integrative genome-phoneme investigation at systems biology level.
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George Washington Community High School: analysis of a partnership network.
Bringle, Robert G; Officer, Starla D H; Grim, Jim; Hatcher, Julie A
2009-01-01
After five years with no public schools in their community, residents and neighborhood organizations of the Near Westside of Indianapolis advocated for the opening of George Washington Community High School (GWCHS). As a neighborhood in close proximity to the campus of Indiana University-Purdue University Indianapolis, the Near Westside and campus worked together to address this issue and improve the educational success of youth. In fall 2000, GWCHS opened as a community school and now thrives as a national model, due in part to its network of community relationships. This account analyzes the development of the school by focusing on the relationships among the university, the high school, community organizations, and the residents of the Near Westside and highlights the unique partnership between the campus and school by defining the relational qualities and describing the network created to make sustainable changes with the high school.
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George Washington: A Hero for American Students?
ERIC Educational Resources Information Center
Jordan, Ervin L., Jr.; Bennett, Clifford T.
1997-01-01
Discusses the career of George Washington with specific emphasis on his racial views and his role as a slaveholder. Describes Washington as a man bound by racial and political mores of his time. Although troubled by certain aspects of slavery, Washington directly benefited from the operation of this system. (MJP)
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Acosta, David; Olsen, Polly
2006-10-01
Minority populations in the United States are growing rapidly, but physician workforce diversity has not kept pace with the needs of underserved communities. Minorities comprised 26.4% of the population in 1995; by 2050, these groups will comprise nearly half. Medical schools must enlist greater numbers of minority physicians and train all physicians to provide culturally responsive care. The University of Washington School of Medicine (UWSOM) is the nation's only medical school that serves a five-state region (Washington, Wyoming, Alaska, Montana, and Idaho). Its mission addresses the need to serve the region, rectify primary care shortages, and meet increasing regional demands for underserved populations. The UWSOM Native American Center of Excellence (NACOE) was established as one important way to respond to this charge. The authors describe pipeline and minority recruitment programs at UWSOM, focusing on the NACOE and other activities to recruit American Indian/Alaskan Native (AI/AN) applicants to medical schools. These programs have increased the numbers of AI/AN medical students; developed the Indian Health Pathway; worked to prepare students to provide culturally responsive care for AI/AN communities; researched health disparities specific to AI/AN populations; provided retention programs and services to ensure successful completion of medical training; developed mentorship networks; and provided faculty-development programs to increase entry of AI/AN physicians into academia. Challenges lie ahead. Barriers to the pipeline will continue to plague students, and inadequate federal funding will have a significant and negative impact on achieving needed physician-workforce diversity. Medical schools must play a larger role in resolving these, and continue to provide pipeline programs, retention programs, and minority faculty development that can make a difference.
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Integrated Research/Education University Aircraft Design Program Development
2017-04-06
iterations and loop shaping compared to MIMO control methods. Despite the drawbacks, loop closure and classical methods are the design methods most commonly...AFRL-AFOSR-VA-TR-2017-0077 Integrated Research/Education University Aircraft Design Program Development Eli Livne UNIVERSITY OF WASHINGTON 4333...SUBTITLE Integrated Research/Education University Aircraft Design Program Development 5a. CONTRACT NUMBER 5b. GRANT NUMBER FA9550-14-1-0027 5c. PROGRAM
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75 FR 67950 - The University of Georgia (UGA), et al.;
Federal Register 2010, 2011, 2012, 2013, 2014
2010-11-04
... DEPARTMENT OF COMMERCE International Trade Administration The University of Georgia (UGA), et al.; Notice of Decision on Applications for Duty-Free Entry of Scientific Instruments This is a decision...., NW., Washington, DC. Docket Number: 10-054. Applicant: The University of Georgia (UGA), Athens, GA...
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USGS Water Data for Washington
,
2009-01-01
The U.S. Geological Survey (USGS) has been investigating the water resources of Washington State since the latter part of the 19th century. During this time, demand for water has evolved from primarily domestic and stock needs to the current complex requirements for public-water supplies, irrigation, power generation, navigation, ecological needs, and numerous other uses. Water-resource data collected by the USGS in Washington have been, or soon will be, published by the USGS Washington Water Science Center (WAWSC) in numerous data and interpretive reports. Most of these reports are available online at the WAWSC web page http://wa.water.usgs.gov/pubs/
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MCNP6 model of the University of Washington clinical neutron therapy system (CNTS).
Moffitt, Gregory B; Stewart, Robert D; Sandison, George A; Goorley, John T; Argento, David C; Jevremovic, Tatjana
2016-01-21
A MCNP6 dosimetry model is presented for the Clinical Neutron Therapy System (CNTS) at the University of Washington. In the CNTS, fast neutrons are generated by a 50.5 MeV proton beam incident on a 10.5 mm thick Be target. The production, scattering and absorption of neutrons, photons, and other particles are explicitly tracked throughout the key components of the CNTS, including the target, primary collimator, flattening filter, monitor unit ionization chamber, and multi-leaf collimator. Simulations of the open field tissue maximum ratio (TMR), percentage depth dose profiles, and lateral dose profiles in a 40 cm × 40 cm × 40 cm water phantom are in good agreement with ionization chamber measurements. For a nominal 10 × 10 field, the measured and calculated TMR values for depths of 1.5 cm, 5 cm, 10 cm, and 20 cm (compared to the dose at 1.7 cm) are within 0.22%, 2.23%, 4.30%, and 6.27%, respectively. For the three field sizes studied, 2.8 cm × 2.8 cm, 10.4 cm × 10.3 cm, and 28.8 cm × 28.8 cm, a gamma test comparing the measured and simulated percent depth dose curves have pass rates of 96.4%, 100.0%, and 78.6% (depth from 1.5 to 15 cm), respectively, using a 3% or 3 mm agreement criterion. At a representative depth of 10 cm, simulated lateral dose profiles have in-field (⩾ 10% of central axis dose) pass rates of 89.7% (2.8 cm × 2.8 cm), 89.6% (10.4 cm × 10.3 cm), and 100.0% (28.8 cm × 28.8 cm) using a 3% and 3 mm criterion. The MCNP6 model of the CNTS meets the minimum requirements for use as a quality assurance tool for treatment planning and provides useful insights and information to aid in the advancement of fast neutron therapy.
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1984-10-13
41G-40-071 (5-13 Oct. 1984) --- Washington, D.C. -- the nation's capital -- is at right center in this phtograph from the Earth-orbiting space shuttle Challenger. J.F. Dulles Airport at lower left. Andrews Air Force Base is at right center edge. The Potomac River enters at left center, flows past Washington and as a tidal estuary at lower right. Also visible are the Great Falls of the Potomac. Photo credit: NASA
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Draft genome sequence of two Shingopyxis sp. strains H107 and H115 isolated from a chloraminated drinking water distriburion system simulatorThis dataset is associated with the following publication:Gomez-Alvarez, V., S. Pfaller , and R. Revetta. Draft Genome of Two Sphingopyxis sp. Strains, Dominant Members of the Bacterial Community Associated with a Drinking Water Distribution System Simulator. Genome Announcements. American Society for Microbiology, Washington, DC, USA, 4(2): e00183-16, (2016).
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Federal Register 2010, 2011, 2012, 2013, 2014
2011-09-19
... items were found in connection with the human remains. The cultural items are consistent with cultural.... History and Description of the Cultural Items In 1953-1954, human remains were removed from the Cedar Cave.... Earl Swanson, Jr. The human remains and objects were transferred from the University of Washington...
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Rieseberg, Loren
2018-02-06
Loren Rieseberg from the University of British Columbia on "The Sunflower Genome and its Evolution" at the 7th Annual Genomics of Energy & Environment Meeting on March 21, 2012 in Walnut Creek, California.
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ERIC Educational Resources Information Center
Reedom, John Anthony
Although comparative analysis of the philosophies of Booker T. Washington and W.E.B. DuBois reveals significant differences in preferred solutions to problems of blacks in the United States, the philosophies of the two men are not as diametrically opposed as scholars have generally maintained. Washington's philosophy was one of conciliation…
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Insights into structural variations and genome rearrangements in prokaryotic genomes.
Periwal, Vinita; Scaria, Vinod
2015-01-01
Structural variations (SVs) are genomic rearrangements that affect fairly large fragments of DNA. Most of the SVs such as inversions, deletions and translocations have been largely studied in context of genetic diseases in eukaryotes. However, recent studies demonstrate that genome rearrangements can also have profound impact on prokaryotic genomes, leading to altered cell phenotype. In contrast to single-nucleotide variations, SVs provide a much deeper insight into organization of bacterial genomes at a much better resolution. SVs can confer change in gene copy number, creation of new genes, altered gene expression and many other functional consequences. High-throughput technologies have now made it possible to explore SVs at a much refined resolution in bacterial genomes. Through this review, we aim to highlight the importance of the less explored field of SVs in prokaryotic genomes and their impact. We also discuss its potential applicability in the emerging fields of synthetic biology and genome engineering where targeted SVs could serve to create sophisticated and accurate genome editing. © The Author 2014. Published by Oxford University Press. All rights reserved. For Permissions, please e-mail: journals.permissions@oup.com.
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Toward an Integrated BAC Library Resource for Genome Sequencing and Analysis
DOE Office of Scientific and Technical Information (OSTI.GOV)
Simon, M. I.; Kim, U.-J.
We developed a great deal of expertise in building large BAC libraries from a variety of DNA sources including humans, mice, corn, microorganisms, worms, and Arabidopsis. We greatly improved the technology for screening these libraries rapidly and for selecting appropriate BACs and mapping BACs to develop large overlapping contigs. We became involved in supplying BACs and BAC contigs to a variety of sequencing and mapping projects and we began to collaborate with Drs. Adams and Venter at TIGR and with Dr. Leroy Hood and his group at University of Washington to provide BACs for end sequencing and for mapping andmore » sequencing of large fragments of chromosome 16. Together with Dr. Ian Dunham and his co-workers at the Sanger Center we completed the mapping and they completed the sequencing of the first human chromosome, chromosome 22. This was published in Nature in 1999 and our BAC contigs made a major contribution to this sequencing effort. Drs. Shizuya and Ding invented an automated highly accurate BAC mapping technique. We also developed long-term collaborations with Dr. Uli Weier at UCSF in the design of BAC probes for characterization of human tumors and specific chromosome deletions and breakpoints. Finally the contribution of our work to the human genome project has been recognized in the publication both by the international consortium and the NIH of a draft sequence of the human genome in Nature last year. Dr. Shizuya was acknowledged in the authorship of that landmark paper. Dr. Simon was also an author on the Venter/Adams Celera project sequencing the human genome that was published in Science last year.« less
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RPAN: rice pan-genome browser for ∼3000 rice genomes.
Sun, Chen; Hu, Zhiqiang; Zheng, Tianqing; Lu, Kuangchen; Zhao, Yue; Wang, Wensheng; Shi, Jianxin; Wang, Chunchao; Lu, Jinyuan; Zhang, Dabing; Li, Zhikang; Wei, Chaochun
2017-01-25
A pan-genome is the union of the gene sets of all the individuals of a clade or a species and it provides a new dimension of genome complexity with the presence/absence variations (PAVs) of genes among these genomes. With the progress of sequencing technologies, pan-genome study is becoming affordable for eukaryotes with large-sized genomes. The Asian cultivated rice, Oryza sativa L., is one of the major food sources for the world and a model organism in plant biology. Recently, the 3000 Rice Genome Project (3K RGP) sequenced more than 3000 rice genomes with a mean sequencing depth of 14.3×, which provided a tremendous resource for rice research. In this paper, we present a genome browser, Rice Pan-genome Browser (RPAN), as a tool to search and visualize the rice pan-genome derived from 3K RGP. RPAN contains a database of the basic information of 3010 rice accessions, including genomic sequences, gene annotations, PAV information and gene expression data of the rice pan-genome. At least 12 000 novel genes absent in the reference genome were included. RPAN also provides multiple search and visualization functions. RPAN can be a rich resource for rice biology and rice breeding. It is available at http://cgm.sjtu.edu.cn/3kricedb/ or http://www.rmbreeding.cn/pan3k. © The Author(s) 2016. Published by Oxford University Press on behalf of Nucleic Acids Research.
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Intra-genotypic Diversity of Archival G4P[8] Human Rotaviruses from Washington, DC
McDonald, Sarah M.; Davis, Kristin; McAllen, John K.; Spiro, David J.; Patton, John T.
2011-01-01
Group A human rotaviruses (RVs) remain the most frequently detected viral agents associated with acute gastroenteritis in infants and young children. Despite their medical importance, relatively few complete genome sequences have been determined for commonly circulating G/P-type strains (i.e., G1P[8], G2P[4], G3P[8], G4P[8], and G9P[8]). In the current study, we sequenced the genomes of 11 G4P[8] isolates from stool specimens that were collected in Washington, DC during the years of 1974-1991. We found that the VP7-VP4-VP6-VP1-VP2-VP3-NSP1-NSP2-NSP3-NSP4-NSP5/6-encoding genes of all 11 G4P[8] RVs have the genotypes of G4-P[8]-I1-R1-C1-M1-A1-N1-T1-E1-H1. By constructing phylogenetic trees for each gene, extensive intra-genotypic diversity was revealed among the G4P[8] RVs, and new sub-genotype gene alleles were identified. Several of these alleles are nearly identical to those of G3P[8] isolates previously sequenced from this same Washington, DC collection, strongly suggesting that the RVs underwent gene reassortment. On the other hand, we observed that some G4P[8] RVs exhibit completely different allele-based genome constellations, despite being collected during the same epidemic season; there was no evidence of gene reassortment between these strains. This observation extends our previous findings and supports the notion that stable, genetically-distinct clades of human RVs with the same G/P-type can co-circulate in a community. Interestingly, the sub-genotype gene alleles found in some of the DC RVs share a close evolutionary relationship with genes of more contemporary human strains. Thus, archival human RVs sequenced in this study might represent evolutionary precursors to modern-day strains. PMID:21712102
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Key Facts about Higher Education in Washington. 2012
ERIC Educational Resources Information Center
Washington Higher Education Coordinating Board, 2012
2012-01-01
"Key Facts about Higher Education in Washington" provides vital data to chart higher education's progress and challenges. First published in 2002 by the Washington Higher Education Coordinating Board, this annual report highlights "Key Facts" about Washington's postsecondary institutions--including faculty, students, budgets,…
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One University's Strategy for Keeping International Projects Running Smoothly
ERIC Educational Resources Information Center
Fischer, Karin
2009-01-01
This article describes how a university tackled some of the basic challenges of internationalizing its campuses. The University of Washington created the Global Support Project, a one-stop shop for faculty and staff members doing research or running programs abroad. The project is run by senior administrators but relies on designated go-to people…
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Cho, Yun Sung; Kim, Hyunho; Kim, Hak-Min; Jho, Sungwoong; Jun, JeHoon; Lee, Yong Joo; Chae, Kyun Shik; Kim, Chang Geun; Kim, Sangsoo; Eriksson, Anders; Edwards, Jeremy S.; Lee, Semin; Kim, Byung Chul; Manica, Andrea; Oh, Tae-Kwang; Church, George M.; Bhak, Jong
2016-01-01
Human genomes are routinely compared against a universal reference. However, this strategy could miss population-specific and personal genomic variations, which may be detected more efficiently using an ethnically relevant or personal reference. Here we report a hybrid assembly of a Korean reference genome (KOREF) for constructing personal and ethnic references by combining sequencing and mapping methods. We also build its consensus variome reference, providing information on millions of variants from 40 additional ethnically homogeneous genomes from the Korean Personal Genome Project. We find that the ethnically relevant consensus reference can be beneficial for efficient variant detection. Systematic comparison of human assemblies shows the importance of assembly quality, suggesting the necessity of new technologies to comprehensively map ethnic and personal genomic structure variations. In the era of large-scale population genome projects, the leveraging of ethnicity-specific genome assemblies as well as the human reference genome will accelerate mapping all human genome diversity. PMID:27882922
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33 CFR 117.1051 - Lake Washington Ship Canal.
Code of Federal Regulations, 2011 CFR
2011-07-01
... 33 Navigation and Navigable Waters 1 2011-07-01 2011-07-01 false Lake Washington Ship Canal. 117.1051 Section 117.1051 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND SECURITY BRIDGES DRAWBRIDGE OPERATION REGULATIONS Specific Requirements Washington § 117.1051 Lake Washington Ship...
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33 CFR 117.1051 - Lake Washington Ship Canal.
Code of Federal Regulations, 2010 CFR
2010-07-01
... 33 Navigation and Navigable Waters 1 2010-07-01 2010-07-01 false Lake Washington Ship Canal. 117.1051 Section 117.1051 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND SECURITY BRIDGES DRAWBRIDGE OPERATION REGULATIONS Specific Requirements Washington § 117.1051 Lake Washington Ship...
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33 CFR 117.1051 - Lake Washington Ship Canal.
Code of Federal Regulations, 2012 CFR
2012-07-01
... 33 Navigation and Navigable Waters 1 2012-07-01 2012-07-01 false Lake Washington Ship Canal. 117.1051 Section 117.1051 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND SECURITY BRIDGES DRAWBRIDGE OPERATION REGULATIONS Specific Requirements Washington § 117.1051 Lake Washington Ship...
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33 CFR 117.1051 - Lake Washington Ship Canal.
Code of Federal Regulations, 2013 CFR
2013-07-01
... 33 Navigation and Navigable Waters 1 2013-07-01 2013-07-01 false Lake Washington Ship Canal. 117.1051 Section 117.1051 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND SECURITY BRIDGES DRAWBRIDGE OPERATION REGULATIONS Specific Requirements Washington § 117.1051 Lake Washington Ship...
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33 CFR 117.1051 - Lake Washington Ship Canal.
Code of Federal Regulations, 2014 CFR
2014-07-01
... 33 Navigation and Navigable Waters 1 2014-07-01 2014-07-01 false Lake Washington Ship Canal. 117.1051 Section 117.1051 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND SECURITY BRIDGES DRAWBRIDGE OPERATION REGULATIONS Specific Requirements Washington § 117.1051 Lake Washington Ship...
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DOE Office of Scientific and Technical Information (OSTI.GOV)
Weinstock, George; Wortman, Jennifer
The Genomic Standards Consortium was formed in September 2005. It is an international, open-membership working body which promotes standardization in the description of genomes and the exchange and integration of genomic data. The 2009 meeting was an activity of a five-year funding Research Coordination Network from the National Science Foundation and was organized held at the DOE Joint Genome Institute with organizational support provided by the JGI and by the University of California - San Diego. George Weinstock from Washington University School of Medicine talks about the Human Microbiome Project (HMP) followed briefly by Jennifer Wortman from the University ofmore » Maryland School of Medicine on the Data Analysis and Coordination Center (DACC) portal to the HMP at the Genomic Standards Consortium's 8th meeting at the DOE JGI in Walnut Creek, CA on Sept. 9, 2009.« less
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Weinstock, George; Wortman, Jennifer
2018-01-22
The Genomic Standards Consortium was formed in September 2005. It is an international, open-membership working body which promotes standardization in the description of genomes and the exchange and integration of genomic data. The 2009 meeting was an activity of a five-year funding Research Coordination Network from the National Science Foundation and was organized held at the DOE Joint Genome Institute with organizational support provided by the JGI and by the University of California - San Diego. George Weinstock from Washington University School of Medicine talks about the Human Microbiome Project (HMP) followed briefly by Jennifer Wortman from the University of Maryland School of Medicine on the Data Analysis and Coordination Center (DACC) portal to the HMP at the Genomic Standards Consortium's 8th meeting at the DOE JGI in Walnut Creek, CA on Sept. 9, 2009.
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A Symposium Associated with the Opening of the Play Copenhagen in Washington
DOE Office of Scientific and Technical Information (OSTI.GOV)
Schwartz, Brian
On March 2, 2002 a special all day symposium was held in conjunction with the opening of the play Copenhagen in Washington. The play Copenhagen reenacts the 1941 visit of Werner Heisenberg, who was then in charge of the Nazi nuclear power program, to Niels Bohr, his mentor, and collaborator in creating quantum mechanics, complementarity, and the uncertainty principle, in German-occupied Denmark. The symposium entitled: THE COPENHAGEN INTERPRETATION: SCIENCE AND HISTORY ON STAGE was presented at the Baird Auditorium, in the National Museum of Natural History of the Smithsonian Institution. The program consisted of three two-hour sessions: (1) The Sciencemore » of Copenhagen and its Influence of the 20th Century. (2) Bohr and Heisenberg: A strong Interaction. (3) Theater as Science ??? Science as Theater. The speakers included: Robert C. Card, Under Secretary of Energy; Ulrik Federspiel, Danish Ambassador to the US; John Marburger, III, Science Advisor President Bush; Jerome I. Friedman, MIT; Lene Vestergaard Hau, Harvard University; Richard Rhodes, Author; Rita Colwell, Director, NSF; Jeremy Bernstein, Author; Jochen H. Heisenberg, University of New Hampshire; Finn Aaserud, Director of the Niels Bohr Archive; Vilhelm A. Bohr, NIH; Thomas Powers, Author; Paul Lawrence Rose, Penn State University; Steven Barfield, University of Westminster, Jennifer Uphoff Gray, Associate Director, Copenhagen; Elizabeth Ireland McCann, Producer, Copenhagen; Lloyd Rose, Washington Post. Details of he program and useful information on the play Copenhagen are available on the web site http://web.gc.cuny.edu/ashp/nml/artsci/copenhagen.shtml . The complete symposium was video recorded and the set of 3 two-hour tapes can be obtained through the web site. The symposium was organized by Brian Schwartz, The Graduate Center, CUNY, Harry Lustig, Provost Emeritus at the City College of New York and Arthur Molella, Director, Lemelson Center, Smithsonian Institution. For further information
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2007 Washington State collision data summary
DOT National Transportation Integrated Search
2008-10-13
In 2007, Washingtons traffic fatality rate decreased to 1.00 per 100 million vehicle miles traveled (VMT), the lowest fatality rate in state history. : Washington State is 27% below the 2007 U.S. fatality rate of 1.37 fatalities per 100 VMT. : Bet...
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2009 Washington State collision data summary
DOT National Transportation Integrated Search
2010-07-02
In 2009, Washingtons traffic fatality rate decreased to 0.87 per 100 million vehicle miles traveled (VMT), the lowest fatality rate in state history. : Washington State is 33% below the 2009 U.S. preliminary fatality rate of 1.16 fatalities per 10...
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2008 Washington State collision data summary
DOT National Transportation Integrated Search
2009-07-28
In 2008, Washingtons traffic fatality rate decreased to 0.94 per 100 million vehicle miles traveled (VMT), the lowest fatality rate in state history. : Washington State is 35% below the 2008 U.S. fatality rate of 1.27 fatalities per 100 VMT. : Bet...
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Conference on Workforce Quality Assessment Held in Washington, DC on 8 May 1989
1989-09-01
of Education Statistics Sar Levitan, Director Department of Education Center for Social Policy Studies George Washington University Michael G. Hansen...wO. it’" Merit Systems Protection Board Office of Personnel Management A Federal Government which is staffed by well qualified and motivated ...long been national policy to provide for a merit-based civil service system. The question of whether we have met the objective of a well qualified
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Goodman, Jessie L; Amendola, Laura M; Horike-Pyne, Martha; Trinidad, Susan B; Fullerton, Stephanie M; Burke, Wylie; Jarvik, Gail P
2017-03-01
Legal and ethical questions arise regarding disseminating genetic research results to family members in the event of a research participant's death; failure to return or return to legal next of kin or estate executor may not reflect participant desires. We sought to determine participant preferences for whether and to whom they would like their data released in the case of their death prior to receiving genomic results, focusing on whether the person selected was also their estate executor. The University of Washington NEXT Medicine Study of the Clinical Sequencing Exploratory Research program previously reported participant preferences regarding designating an individual to receive genomic results in the event of death, including whether they want results shared, and if so, with what person. Participants were also asked whether this designee is executor of their will or estate. To date, 61 individuals were asked about the concordance of their study designee and legal representative: 42 (69%) reported having a will or estate plan and of these, 14 (33%) chose someone other than their executor to receive their results. For the 14 who chose someone other than their estate executor to receive genetic results, 12 (86%) chose a family member, typically a biological relative, as their designee. Those with a different genomic designee than their executor were less likely to be partnered ( P = 0.0024). For those partnered participants without an estate plan, spouses were not always chosen for return of genomic results. For one-third of our participants, the individual deemed most appropriate by the participant to receive their genomic results was not the executor. In the absence of an explicit designation, HIPAA may prohibit access to genomic results to persons other than the executor; hence asking for designation at the time of study enrollment (or initiation of clinical testing) is important.
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1979-1980 Geothermal Resource Assessment Program in Washington
DOE Office of Scientific and Technical Information (OSTI.GOV)
Korosec, M.A.; Schuster, J.E.
1980-01-01
Separate abstracts were prepared for seven papers. Also included are a bibliography of geothermal resource information for the State of Washington, well temperature information and locations in the State of Washington, and a map of the geology of the White Pass-Tumac Mountain Area, Washington. (MHR)
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A Fragile Coalition: University and High School.
ERIC Educational Resources Information Center
Smith, Eugene
1981-01-01
Since 1978, the University of Washington has offered two of its freshman writing courses at Sequim High School, for advanced students wishing to earn college credit. The author discusses program's operations, advantages, and disadvantages, and compares it to the Advanced Placement Program. (SJL)
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NASA Astrophysics Data System (ADS)
Rosenfield, Philip
2013-01-01
Graduate students in the astronomy department at the University of Washington began the Pre-Major in Astronomy Program (Pre-MAP) after recognizing that underrepresented students in STEM fields are not well retained after their transition from high school. Pre-MAP is a research and mentoring program that begins with a keystone seminar. First year students enroll in the Pre-MAP seminar to learn astronomical research techniques that they apply to research projects conducted in small groups. Students also receive one-on-one mentoring and peer support for the duration of the academic year and beyond. They are incorporated early into the department by attending Astronomy Department events and Pre-MAP field trips. Successful Pre-MAP students have declared astronomy and physics majors, expanded their research projects beyond the fall quarter, presented posters at the UW Undergraduate Research Symposium, and received research fellowships and summer internships. In this talk, we will discuss how we identified the issues that Pre-MAP was designed to address, what we've learned after six years of Pre-MAP, and share statistical results from a long-term quantitative comparison evaluation.
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Reduced representation approaches to interrogate genome diversity in large repetitive plant genomes.
Hirsch, Cory D; Evans, Joseph; Buell, C Robin; Hirsch, Candice N
2014-07-01
Technology and software improvements in the last decade now provide methodologies to access the genome sequence of not only a single accession, but also multiple accessions of plant species. This provides a means to interrogate species diversity at the genome level. Ample diversity among accessions in a collection of species can be found, including single-nucleotide polymorphisms, insertions and deletions, copy number variation and presence/absence variation. For species with small, non-repetitive rich genomes, re-sequencing of query accessions is robust, highly informative, and economically feasible. However, for species with moderate to large sized repetitive-rich genomes, technical and economic barriers prevent en masse genome re-sequencing of accessions. Multiple approaches to access a focused subset of loci in species with larger genomes have been developed, including reduced representation sequencing, exome capture and transcriptome sequencing. Collectively, these approaches have enabled interrogation of diversity on a genome scale for large plant genomes, including crop species important to worldwide food security. © The Author 2014. Published by Oxford University Press. All rights reserved. For permissions, please email: journals.permissions@oup.com.
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USDA-ARS?s Scientific Manuscript database
The ARS Microbial Genome Sequence Database (http://199.133.98.43), a web-based database server, was established utilizing the BIGSdb (Bacterial Isolate Genomics Sequence Database) software package, developed at Oxford University, as a tool to manage multi-locus sequence data for the family Streptomy...
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The Washington DC Metro Area Lightning Mapping Array
NASA Technical Reports Server (NTRS)
Krehbiel, Paul; Rison, William; Edens, Harald; OConnor, Nicholas; Aulich, Graydon; Thomas, Ronald; Kieft, Sandra; Goodman, Steven; Blakeslee, Richard; Hall, John;
2006-01-01
During the spring and summer of 2006, a network of eight lightning mapping stations has been set up in the greater DC metropolitan area to monitor the total lightning activity in storms over Virginia, Maryland and the Washington DC area. The network is a joint project between New Mexico Tech, NASA, and NOAA/National Weather Service, with real-time data being provided to the NWS for use in their forecast and warning operations. The network utilizes newly available portable stations developed with support from the National Science Foundation. Cooperating institutions involved in hosting mapping stations are Howard University, Montgomery County Community College in Rockville MD, NOAA/NWS's Test and Evaluation Site in Sterling, VA, College of Southern Maryland near La Plata MD, the Applied Physics Laboratory of Johns Hopkins University, Northern Virginia Community College in Annandale, VA, the University of Maryland at Baltimore County, and George Mason University (Prince William Campus) in Manassas, VA. The network is experimental in that its stations a) operate in the upper rather than the lower VHF (TV channel 10, 192-198 MHz) to reduce the radio frequency background noise associated with urban environments, and b) are linked to the central processing site via the internet rather than by dedicated wireless communication links. The central processing is done in Huntsville, AL, and updated observations are sent to the National Weather Service every 2 min. The observational data will also be available on a public website. The higher operating frequency results in a decrease in signal strength estimated to be about 15-20 dB, relative to the LMA networks being operated in northern Alabama and central Oklahoma (which operate on TV channels 5 and 3, respectively). This is offset somewhat by decreased background noise levels at many stations. The receiver threshold levels range from about -95 dBm up to -80 dBm and the peak lightning signals typically extend 15-20 dB above
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Chernock, Rebecca D.; Leach, Tracey A.; Kahn, Ajaz A.; Yip, James H.; Rossi, Joan; Pfeifer, John D.
2011-01-01
Academic hospitals and medical schools with research tissue repositories often derive many of their internal human specimen acquisitions from their site's surgical pathology service. Typically, such acquisitions come from appropriately consented tissue discards sampled from surgical resections. Because the practice of surgical pathology has patient care as its primary mission, competing needs for tissue inevitably arise, with the requirement to preserve adequate tissue for clinical diagnosis being paramount. A set of best-practice gross pathology guidelines are summarized here, focused on the decision for tissue banking at the time specimens are macroscopically evaluated. These reflect our collective experience at Washington University School of Medicine, and are written from the point of view of our site biorepository. The involvement of trained pathology personnel in such procurements is very important. These guidelines reflect both good surgical pathology practice (including the pathologic features characteristic of various anatomic sites) and the typical objectives of research biorepositories. The guidelines should be helpful to tissue bank directors, and others charged with the procurement of tissues for general research purposes. We believe that appreciation of these principles will facilitate the partnership between surgical pathologists and biorepository directors, and promote both good patient care and strategic, value-added banking procurements. PMID:23386925
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NASA Astrophysics Data System (ADS)
Rumburg, B.; Yonge, D.; Jacob, J.
2003-12-01
The under-representation of Native Americans in engineering and science at the student and practicing engineer or scientist level is a national problem. To begin addressing this problem Washington State University (WSU) has initiated discussio with local Native American tribes to strengthen the relationship between WSU and the tribes and to improve the educational opportunities available to tribal members. The Center for Multiphase Environmental Research (CMER) received a 1999 National Science Foundation (NSF) Integrative Graduate Education and Research Training (IGERT) grant to train Ph.D. students. The main goal of the program is to foster multidisciplinary research and education for future scientists and engineers in the broad field of study that incorporates the fate and transport of environmentally significant species between interfaces. We are also focused on recruiting and educating Native American students. CMER is committed to cultivating its relationship with Native American tribes by identifying the environmental concerns of the tribes and developing collaborative research efforts utilizing CMER's infrastructure. Through these collaborative projects the CMER hopes to better understand the social and cultural aspects important to the tribes and develop the familiarity needed to effectively enhance student recruitment. This poster highlights the CMER's interdisciplinary research and teaching efforts and focuses on Native American recruitment.
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Applications of the 1000 Genomes Project resources.
Zheng-Bradley, Xiangqun; Flicek, Paul
2017-05-01
The 1000 Genomes Project created a valuable, worldwide reference for human genetic variation. Common uses of the 1000 Genomes dataset include genotype imputation supporting Genome-wide Association Studies, mapping expression Quantitative Trait Loci, filtering non-pathogenic variants from exome, whole genome and cancer genome sequencing projects, and genetic analysis of population structure and molecular evolution. In this article, we will highlight some of the multiple ways that the 1000 Genomes data can be and has been utilized for genetic studies. © The Author 2016. Published by Oxford University Press.
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Kim, Ann H; Augustin, Gener; Shevitz, Andrew; Kim, Hannah; Trivonovich, Michael R; Powell, Alexis R; Kumins, Norman; Tarr, Robert; Kashyap, Vikram S
2018-04-01
The decision to intervene for internal carotid stenosis often depends on the degree of stenosis seen on duplex ultrasound (US). The aim of this study is to compare the diagnostic accuracy of two criteria: modified University of Washington (UW) and 2003 Carotid Consensus Panel (CCP). All patients undergoing US in an accredited (IAC) vascular laboratory from January 2010 to June 2015 were reviewed ( n=18,772 US exams). Patients receiving a neck computed tomography angiography (CTA) within 6 months of the US were included in the study ( n=254). The degree of stenosis was determined by UW/CCP criteria and confirmed on CTA images using North American Symptomatic Carotid Endarterectomy Trial (NASCET)/European Carotid Surgery Trial (ECST) schema. Kappa analysis with 95% confidence intervals (CIs) were utilized to determine duplex-CTA agreement. A total of 417 carotid arteries from 221 patients were assessed in this study. The modified UW criteria accurately classified 266 (63.9%, kappa = 0.321, 95% CI 0.255 to 0.386) cases according to NASCET-derived measurements. The sensitivity, specificity, and accuracy at ≥ 60% stenosis were 65.7%, 81.3%, and 81.9%. The CCP criteria resulted in 296 (70.9%) accurate diagnoses (kappa = 0.359, 95% CI 0.280 to 0.437). At ≥ 70% stenosis, the sensitivity, specificity and accuracy were 38.8%, 91.6%, and 87.1% for NASCET. Comparison of the duplex results to ECST-derived CTA measurements revealed a similar trend (UW 53.1%, κ = 0.301 vs CCP 62.1%, κ = 0.315). The CCP criteria demonstrate a higher concordance rate with measurements taken from CTAs. The CCP criteria may be more sensitive in classifying clinically significant degrees of stenosis without a loss in diagnostic accuracy.
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NASA Astrophysics Data System (ADS)
Stone, S.; Parker, M. S.; Howe, B.; Lazowska, E.
2015-12-01
Rapid advances in technology are transforming nearly every field from "data-poor" to "data-rich." The ability to extract knowledge from this abundance of data is the cornerstone of 21st century discovery. At the University of Washington eScience Institute, our mission is to engage researchers across disciplines in developing and applying advanced computational methods and tools to real world problems in data-intensive discovery. Our research team consists of individuals with diverse backgrounds in domain sciences such as astronomy, oceanography and geology, with complementary expertise in advanced statistical and computational techniques such as data management, visualization, and machine learning. Two key elements are necessary to foster careers in data science: individuals with cross-disciplinary training in both method and domain sciences, and career paths emphasizing alternative metrics for advancement. We see persistent and deep-rooted challenges for the career paths of people whose skills, activities and work patterns don't fit neatly into the traditional roles and success metrics of academia. To address these challenges the eScience Institute has developed training programs and established new career opportunities for data-intensive research in academia. Our graduate students and post-docs have mentors in both a methodology and an application field. They also participate in coursework and tutorials to advance technical skill and foster community. Professional Data Scientist positions were created to support research independence while encouraging the development and adoption of domain-specific tools and techniques. The eScience Institute also supports the appointment of faculty who are innovators in developing and applying data science methodologies to advance their field of discovery. Our ultimate goal is to create a supportive environment for data science in academia and to establish global recognition for data-intensive discovery across all fields.
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proGenomes: a resource for consistent functional and taxonomic annotations of prokaryotic genomes.
Mende, Daniel R; Letunic, Ivica; Huerta-Cepas, Jaime; Li, Simone S; Forslund, Kristoffer; Sunagawa, Shinichi; Bork, Peer
2017-01-04
The availability of microbial genomes has opened many new avenues of research within microbiology. This has been driven primarily by comparative genomics approaches, which rely on accurate and consistent characterization of genomic sequences. It is nevertheless difficult to obtain consistent taxonomic and integrated functional annotations for defined prokaryotic clades. Thus, we developed proGenomes, a resource that provides user-friendly access to currently 25 038 high-quality genomes whose sequences and consistent annotations can be retrieved individually or by taxonomic clade. These genomes are assigned to 5306 consistent and accurate taxonomic species clusters based on previously established methodology. proGenomes also contains functional information for almost 80 million protein-coding genes, including a comprehensive set of general annotations and more focused annotations for carbohydrate-active enzymes and antibiotic resistance genes. Additionally, broad habitat information is provided for many genomes. All genomes and associated information can be downloaded by user-selected clade or multiple habitat-specific sets of representative genomes. We expect that the availability of high-quality genomes with comprehensive functional annotations will promote advances in clinical microbial genomics, functional evolution and other subfields of microbiology. proGenomes is available at http://progenomes.embl.de. © The Author(s) 2016. Published by Oxford University Press on behalf of Nucleic Acids Research.
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30 CFR 947.700 - Washington Federal program.
Code of Federal Regulations, 2013 CFR
2013-07-01
... PROGRAMS FOR THE CONDUCT OF SURFACE MINING OPERATIONS WITHIN EACH STATE WASHINGTON § 947.700 Washington... necessary because of the nature of the terrain, climate, biological, chemical, or other relevant physical...
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30 CFR 947.700 - Washington Federal program.
Code of Federal Regulations, 2014 CFR
2014-07-01
... PROGRAMS FOR THE CONDUCT OF SURFACE MINING OPERATIONS WITHIN EACH STATE WASHINGTON § 947.700 Washington... necessary because of the nature of the terrain, climate, biological, chemical, or other relevant physical...
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30 CFR 947.700 - Washington Federal program.
Code of Federal Regulations, 2012 CFR
2012-07-01
... PROGRAMS FOR THE CONDUCT OF SURFACE MINING OPERATIONS WITHIN EACH STATE WASHINGTON § 947.700 Washington... necessary because of the nature of the terrain, climate, biological, chemical, or other relevant physical...
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30 CFR 947.700 - Washington Federal program.
Code of Federal Regulations, 2011 CFR
2011-07-01
... PROGRAMS FOR THE CONDUCT OF SURFACE MINING OPERATIONS WITHIN EACH STATE WASHINGTON § 947.700 Washington... necessary because of the nature of the terrain, climate, biological, chemical, or other relevant physical...
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Toward a Preventive Environmental Education Curriculum: The Washington State University Experience.
ERIC Educational Resources Information Center
Simpson, Julie D.; Budd, William W.
1996-01-01
Describes the development of a university course in pollution prevention. Highlights the collaborative, interdisciplinary, and applied aspects of the curriculum. Discusses evaluations by students, instructors, and university facility managers that provide evidence that the course is an effective model for educating students and businesses. (JRH)
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Siah, Ahmed; Morrison, Diane B.; Fringuelli, Elena; Savage, Paul S.; Richmond, Zina; Purcell, Maureen K.; Johns, Robert; Johnson, Stewart C.; Sakasida, Sonja M.
2015-01-01
Piscine reovirus (PRV) is a double stranded non-enveloped RNA virus detected in farmed and wild salmonids. This study examined the phylogenetic relationships among different PRV sequence types present in samples from salmonids in Western Canada and the US, including Alaska (US), British Columbia (Canada) and Washington State (US). Tissues testing positive for PRV were partially sequenced for segment S1, producing 71 sequences that grouped into 10 unique sequence types. Sequence analysis revealed no identifiable geographical or temporal variation among the sequence types. Identical sequence types were found in fish sampled in 2001, 2005 and 2014. In addition, PRV positive samples from fish derived from Alaska, British Columbia and Washington State share identical sequence types. Comparative analysis of the phylogenetic tree indicated that Canada/US Pacific Northwest sequences formed a subgroup with some Norwegian sequence types (group II), distinct from other Norwegian and Chilean sequences (groups I, III and IV). Representative PRV positive samples from farmed and wild fish in British Columbia and Washington State were subjected to genome sequencing using next generation sequencing methods. Individual analysis of each of the 10 partial segments indicated that the Canadian and US PRV sequence types clustered separately from available whole genome sequences of some Norwegian and Chilean sequences for all segments except the segment S4. In summary, PRV was genetically homogenous over a large geographic distance (Alaska to Washington State), and the sequence types were relatively stable over a 13 year period.
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Siah, Ahmed; Morrison, Diane B.; Fringuelli, Elena; Savage, Paul; Richmond, Zina; Johns, Robert; Purcell, Maureen K.; Johnson, Stewart C.; Saksida, Sonja M.
2015-01-01
Piscine reovirus (PRV) is a double stranded non-enveloped RNA virus detected in farmed and wild salmonids. This study examined the phylogenetic relationships among different PRV sequence types present in samples from salmonids in Western Canada and the US, including Alaska (US), British Columbia (Canada) and Washington State (US). Tissues testing positive for PRV were partially sequenced for segment S1, producing 71 sequences that grouped into 10 unique sequence types. Sequence analysis revealed no identifiable geographical or temporal variation among the sequence types. Identical sequence types were found in fish sampled in 2001, 2005 and 2014. In addition, PRV positive samples from fish derived from Alaska, British Columbia and Washington State share identical sequence types. Comparative analysis of the phylogenetic tree indicated that Canada/US Pacific Northwest sequences formed a subgroup with some Norwegian sequence types (group II), distinct from other Norwegian and Chilean sequences (groups I, III and IV). Representative PRV positive samples from farmed and wild fish in British Columbia and Washington State were subjected to genome sequencing using next generation sequencing methods. Individual analysis of each of the 10 partial segments indicated that the Canadian and US PRV sequence types clustered separately from available whole genome sequences of some Norwegian and Chilean sequences for all segments except the segment S4. In summary, PRV was genetically homogenous over a large geographic distance (Alaska to Washington State), and the sequence types were relatively stable over a 13 year period. PMID:26536673
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Hydrogeology and history of Washington, D.C.
NASA Astrophysics Data System (ADS)
For Washington, D.C., inhabitants or anyone planning a trip to the area, interesting information on the hydrology, geology, and natural and cultural history is available.To provide geographic and historical background for field trips in the area, a book was published for the 28th International Geological Congress, held in Washington in July 1989. Geology, Hydrology, and History of the Washington, D.C. Area, edited by John E. Moore of the U.S. Geological Survey, Reston, Va., and Julia A. Jackson of the American Geological Institute, Alexandria, Va., describes such interesting items as the Washington Canal, which ran from the Potomac River to the Capitol and is now Constitution Avenue, and the Cabin John Aqueduct, where a 297-foot granite arch was the longest masonry arch in the world for 40 years. The aqueduct has carried water to Washington since 1863. The 114-page book contains many historic photographs and maps and can be purchased from the American Geological Institute, 4220 King Street, Alexandria, VA 22302-1507, tel. 703-379-2480.
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Critical congenital heart disease screening practices among licensed midwives in washington state.
Evers, Patrick D; Vernon, Margaret M; Schultz, Amy H
2015-01-01
Since 2011, pulse oximetry screening for critical congenital heart disease (CCHD) has been recommended for newborns. Initial implementation guidelines focused on in-hospital births. Recent publications affirm the importance of universal screening, including for out-of-hospital births. No published data describe CCHD screening rates for out-of-hospital births. Licensed midwives in Washington state were surveyed regarding their current CCHD screening practices, volume of births attended annually, and typical newborn follow-up practices. For those who indicated they were screening, additional information was obtained about equipment used, timing of screening, and rationale for voluntarily initiating screening. For those who indicated that they were not screening, information regarding barriers to implementation was solicited. Of the 61 midwives in our sample, 98% indicated they were aware of published guidelines recommending universal newborn screening for CCHD utilizing pulse oximetry. Furthermore, 52% indicated that they were screening for CCHD currently. Ten percent stated they do not intend to screen, whereas the remaining respondents indicated that they plan to screen in the future. The primary barriers to screening were the cost of pulse oximetry equipment and inadequate training in screening technique and interpretation. Although voluntary implementation of CCHD screening by licensed midwives in Washington is increasing, it lags behind the implementation rates reported for in-hospital births. © 2015 by the American College of Nurse-Midwives.
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Washington: "...By Ability, Politeness, and Attention."
ERIC Educational Resources Information Center
Bingham, Marjorie Wall
1997-01-01
Examines the career of George Washington, particularly emphasizing his skills as a mediator and negotiator. Postulates that the origins of these skills are in Washington's upbringing and his role as the leader of a large extended family. Argues that, as a national leader, he effectively employed these same skills. (MJP)
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Washington Tsunami Hazard Mitigation Program
NASA Astrophysics Data System (ADS)
Walsh, T. J.; Schelling, J.
2012-12-01
Washington State has participated in the National Tsunami Hazard Mitigation Program (NTHMP) since its inception in 1995. We have participated in the tsunami inundation hazard mapping, evacuation planning, education, and outreach efforts that generally characterize the NTHMP efforts. We have also investigated hazards of significant interest to the Pacific Northwest. The hazard from locally generated earthquakes on the Cascadia subduction zone, which threatens tsunami inundation in less than hour following a magnitude 9 earthquake, creates special problems for low-lying accretionary shoreforms in Washington, such as the spits of Long Beach and Ocean Shores, where high ground is not accessible within the limited time available for evacuation. To ameliorate this problem, we convened a panel of the Applied Technology Council to develop guidelines for construction of facilities for vertical evacuation from tsunamis, published as FEMA 646, now incorporated in the International Building Code as Appendix M. We followed this with a program called Project Safe Haven (http://www.facebook.com/ProjectSafeHaven) to site such facilities along the Washington coast in appropriate locations and appropriate designs to blend with the local communities, as chosen by the citizens. This has now been completed for the entire outer coast of Washington. In conjunction with this effort, we have evaluated the potential for earthquake-induced ground failures in and near tsunami hazard zones to help develop cost estimates for these structures and to establish appropriate tsunami evacuation routes and evacuation assembly areas that are likely to to be available after a major subduction zone earthquake. We intend to continue these geotechnical evaluations for all tsunami hazard zones in Washington.
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Smith, David Roy
2017-05-01
Next-generation sequencing technologies have revolutionized genomics and altered the scientific publication landscape. Life-science journals abound with genome papers-peer-reviewed descriptions of newly sequenced chromosomes. Although they once filled the pages of Nature and Science, genome papers are now mostly relegated to journals with low-impact factors. Some have forecast the death of the genome paper and argued that they are using up valuable resources and not advancing science. However, the publication rate of genome papers is on the rise. This increase is largely because some journals have created a new category of manuscript called genome reports, which are short, fast-tracked papers describing a chromosome sequence(s), its GenBank accession number and little else. In 2015, for example, more than 2000 genome reports were published, and 2016 is poised to bring even more. Here, I highlight the growing popularity of genome reports and discuss their merits, drawbacks and impact on science and the academic publication infrastructure. Genome reports can be excellent assets for the research community, but they are also being used as quick and easy routes to a publication, and in some instances they are not peer reviewed. One of the best arguments for genome reports is that they are a citable, user-generated genomic resource providing essential methodological and biological information, which may not be present in the sequence database. But they are expensive and time-consuming avenues for achieving such a goal. © The Author 2016. Published by Oxford University Press.
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Evaluation of the Washington State Target Zero teams project.
DOT National Transportation Integrated Search
2015-01-01
As part of its Target Zero strategic highway safety plan that has the goal to reduce traffic fatalities in Washington to zero by the year 2030, the State of Washington established three detachments of Washington State Patrol (WSP) troopers to f...
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Perception of Natural Hazards and Risk among University of Washington Students
NASA Astrophysics Data System (ADS)
Herr, K.; Brand, B.; Hamlin, N.; Ou, J.; Thomas, B.; Tudor, E.
2012-12-01
Familiarity with a given population's perception of natural hazards and the threats they present is vital for the development of effective education prior to and emergency management response after a natural event. While much work has been done in other active tectonic regions, perception of natural hazards and risk among Pacific Northwest (PNW) residents is poorly constrained. The objective of this work is to assess the current perception of earthquake and volcanic hazards and risk in the PNW, and to better understand the factors which drive the public's behavior concerning preparedness and response. We developed a survey to assess the knowledge of natural hazards common to the region, their perception of risk concerning these hazards, and their level of preparedness should a natural hazard occur. The survey was distributed to University of Washington students and employees via an internet link as part of a class project in 'Living with Volcanoes' (ESS 106) in March of 2012, which returned more than 900 responses. The UW student population was chosen as our first "population" to assess because of their uniqueness as a large, semi-transient population (typical residence of less than 5 years). Only 50% of participants correctly reported their proximity to an active volcano, indicating either lack of knowledge of active volcanoes in the region or poor spatial awareness. When asked which area were most at risk to lahars, respondents indicated that all areas close to the hazard source, including topographically elevated regions, were at a higher risk than more distal and low-lying localities that are also at high risk, indicating a lack of knowledge concerning the topographic dependency of this hazard. Participants perceived themselves to be able to cope better with an earthquake than a volcanic event. This perception may be due to lack of knowledge of volcanic hazards and their extent or due to a false sense of security concerning earthquakes fostered by regular
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ERIC Educational Resources Information Center
White, Alison J.; Teuteberg, Dan
2015-01-01
Washington's 4-H program is transitioning from a predominately single-county faculty model to a regional system. This article highlights survey results regarding the level of awareness and buy-in that Extension administration, faculty, and staff have concerning the regional model and how communication about the model took place. While most…
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Addition of a breeding database in the Genome Database for Rosaceae.
Evans, Kate; Jung, Sook; Lee, Taein; Brutcher, Lisa; Cho, Ilhyung; Peace, Cameron; Main, Dorrie
2013-01-01
Breeding programs produce large datasets that require efficient management systems to keep track of performance, pedigree, geographical and image-based data. With the development of DNA-based screening technologies, more breeding programs perform genotyping in addition to phenotyping for performance evaluation. The integration of breeding data with other genomic and genetic data is instrumental for the refinement of marker-assisted breeding tools, enhances genetic understanding of important crop traits and maximizes access and utility by crop breeders and allied scientists. Development of new infrastructure in the Genome Database for Rosaceae (GDR) was designed and implemented to enable secure and efficient storage, management and analysis of large datasets from the Washington State University apple breeding program and subsequently expanded to fit datasets from other Rosaceae breeders. The infrastructure was built using the software Chado and Drupal, making use of the Natural Diversity module to accommodate large-scale phenotypic and genotypic data. Breeders can search accessions within the GDR to identify individuals with specific trait combinations. Results from Search by Parentage lists individuals with parents in common and results from Individual Variety pages link to all data available on each chosen individual including pedigree, phenotypic and genotypic information. Genotypic data are searchable by markers and alleles; results are linked to other pages in the GDR to enable the user to access tools such as GBrowse and CMap. This breeding database provides users with the opportunity to search datasets in a fully targeted manner and retrieve and compare performance data from multiple selections, years and sites, and to output the data needed for variety release publications and patent applications. The breeding database facilitates efficient program management. Storing publicly available breeding data in a database together with genomic and genetic data will
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SMART on FHIR Genomics: facilitating standardized clinico-genomic apps.
Alterovitz, Gil; Warner, Jeremy; Zhang, Peijin; Chen, Yishen; Ullman-Cullere, Mollie; Kreda, David; Kohane, Isaac S
2015-11-01
Supporting clinical decision support for personalized medicine will require linking genome and phenome variants to a patient's electronic health record (EHR), at times on a vast scale. Clinico-genomic data standards will be needed to unify how genomic variant data are accessed from different sequencing systems. A specification for the basis of a clinic-genomic standard, building upon the current Health Level Seven International Fast Healthcare Interoperability Resources (FHIR®) standard, was developed. An FHIR application protocol interface (API) layer was attached to proprietary sequencing platforms and EHRs in order to expose gene variant data for presentation to the end-user. Three representative apps based on the SMART platform were built to test end-to-end feasibility, including integration of genomic and clinical data. Successful design, deployment, and use of the API was demonstrated and adopted by HL7 Clinical Genomics Workgroup. Feasibility was shown through development of three apps by various types of users with background levels and locations. This prototyping work suggests that an entirely data (and web) standards-based approach could prove both effective and efficient for advancing personalized medicine. © The Author 2015. Published by Oxford University Press on behalf of the American Medical Informatics Association. All rights reserved. For Permissions, please email: journals.permissions@oup.com.
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Timber resource statistics for southwest Washington.
John W. Hazard
1965-01-01
This publication summarizes the results of the third reinventory of six counties in southwest Washington: Clark, Cowlitz, Lewis, Pacific, Skamania, and Wahkiakurn. This block of 6 counties is one of 10 such blocks set up in the States of Oregon and Washington by the Forest Survey to facilitate orderly reinventories of the timber resources. Each block will be...
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1981-09-01
4 GRAYS HARBOR AND CHEHALIS RIVER IMPROVEMENTS TO NAVIGATION ENVIRONMENTAL STUDIES COMMUNITY STRUCTURE AND STANDING © STOCK OF EPIBENTHIC... FISHERIES RESEARCH INSTITUTE %r UNIVERSITY OF WASHINGTON B of Engineers SEPTEMBER 1981 Seattle District(DISTRIBUTION STATEM EN T. -A-8-1 2 7 Approved...PERIOD COVERED Community Structure and Standing Stock of Final May 7. 1981 Epibenthic Zooplankton at Five Sites in 6. PERFORMING ORG. REPORT NUMBER
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OryzaGenome: Genome Diversity Database of Wild Oryza Species.
Ohyanagi, Hajime; Ebata, Toshinobu; Huang, Xuehui; Gong, Hao; Fujita, Masahiro; Mochizuki, Takako; Toyoda, Atsushi; Fujiyama, Asao; Kaminuma, Eli; Nakamura, Yasukazu; Feng, Qi; Wang, Zi-Xuan; Han, Bin; Kurata, Nori
2016-01-01
The species in the genus Oryza, encompassing nine genome types and 23 species, are a rich genetic resource and may have applications in deeper genomic analyses aiming to understand the evolution of plant genomes. With the advancement of next-generation sequencing (NGS) technology, a flood of Oryza species reference genomes and genomic variation information has become available in recent years. This genomic information, combined with the comprehensive phenotypic information that we are accumulating in our Oryzabase, can serve as an excellent genotype-phenotype association resource for analyzing rice functional and structural evolution, and the associated diversity of the Oryza genus. Here we integrate our previous and future phenotypic/habitat information and newly determined genotype information into a united repository, named OryzaGenome, providing the variant information with hyperlinks to Oryzabase. The current version of OryzaGenome includes genotype information of 446 O. rufipogon accessions derived by imputation and of 17 accessions derived by imputation-free deep sequencing. Two variant viewers are implemented: SNP Viewer as a conventional genome browser interface and Variant Table as a text-based browser for precise inspection of each variant one by one. Portable VCF (variant call format) file or tab-delimited file download is also available. Following these SNP (single nucleotide polymorphism) data, reference pseudomolecules/scaffolds/contigs and genome-wide variation information for almost all of the closely and distantly related wild Oryza species from the NIG Wild Rice Collection will be available in future releases. All of the resources can be accessed through http://viewer.shigen.info/oryzagenome/. © The Author 2015. Published by Oxford University Press on behalf of Japanese Society of Plant Physiologists.
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Baltimore-Washington Parkway, Maryland : traffic safety plan
DOT National Transportation Integrated Search
2015-06-01
Over the past decade, a number of studies have documented the traffic safety issues on the National Park Services (NPS) portion of the Baltimore-Washington (B-W) Parkway. The Baltimore-Washington Parkway Traffic Safety Plan provides an action plan...
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Strategic Programming for Early University Entrants: Creating Support for Socio-Emotional Needs
ERIC Educational Resources Information Center
Lancour, Julie A.
2011-01-01
This article introduces "Resiliency Training," a program designed to support early university entrants as they take on the challenges and adventures of their sophomore and junior year at the University of Washington (UW). As the Academic Counselor and Counseling Services Coordinator for the Robinson Center, watching the students engage…
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Federal Register 2010, 2011, 2012, 2013, 2014
2012-06-06
... DEPARTMENT OF COMMERCE International Trade Administration The Regents of the University of...: Washington University in St. Louis, Saint Louis, MO 63130. Instrument: Electron Microscope. Manufacturer: FEI.... Applicant: The Regents of the University of California, Berkeley, CA 94720. Instrument: Electron Microscope...
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- state and local licensing and registration requirements. Watch - Find out what legal aid clients and Microsoft President Brad Smith have to say in this short video - Civil Legal Aid in Washington State. Health
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Darwinian evolution in the light of genomics
Koonin, Eugene V.
2009-01-01
Comparative genomics and systems biology offer unprecedented opportunities for testing central tenets of evolutionary biology formulated by Darwin in the Origin of Species in 1859 and expanded in the Modern Synthesis 100 years later. Evolutionary-genomic studies show that natural selection is only one of the forces that shape genome evolution and is not quantitatively dominant, whereas non-adaptive processes are much more prominent than previously suspected. Major contributions of horizontal gene transfer and diverse selfish genetic elements to genome evolution undermine the Tree of Life concept. An adequate depiction of evolution requires the more complex concept of a network or ‘forest’ of life. There is no consistent tendency of evolution towards increased genomic complexity, and when complexity increases, this appears to be a non-adaptive consequence of evolution under weak purifying selection rather than an adaptation. Several universals of genome evolution were discovered including the invariant distributions of evolutionary rates among orthologous genes from diverse genomes and of paralogous gene family sizes, and the negative correlation between gene expression level and sequence evolution rate. Simple, non-adaptive models of evolution explain some of these universals, suggesting that a new synthesis of evolutionary biology might become feasible in a not so remote future. PMID:19213802
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Iverson, Richard M.; LeVeque, Randall J.
2009-01-01
A recent workshop at the University of Washington focused on mathematical and computational aspects of modeling the dynamics of dense, gravity-driven mass movements such as rock avalanches and debris flows. About 30 participants came from seven countries and brought diverse backgrounds in geophysics; geology; physics; applied and computational mathematics; and civil, mechanical, and geotechnical engineering. The workshop was cosponsored by the U.S. Geological Survey Volcano Hazards Program, by the U.S. National Science Foundation through a Vertical Integration of Research and Education (VIGRE) in the Mathematical Sciences grant to the University of Washington, and by the Pacific Institute for the Mathematical Sciences. It began with a day of lectures open to the academic community at large and concluded with 2 days of focused discussions and collaborative work among the participants.
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ERIC Educational Resources Information Center
Western Interstate Commission for Higher Education, 2006
2006-01-01
In Washington, the demand for well-educated employees will only increase over the next several years. In the decade leading up to 2012, healthcare occupations will see growth of 20 percent. Teachers will be in demand: nearly 9,000 new elementary and middle-school educators will need to be hired. Computer fields will undergo growth of 24 percent,…
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Justifying and Developing a Comprehensive Wellness-Fitness Institute on a University Campus.
ERIC Educational Resources Information Center
Cardinal, Bradley J.
An overview of The Body Shop wellness program at Eastern Washington University provides information on enrollment figures, demographic data, physiological improvements, and the results of a survey of participants' attitudes toward and perceptions of the program. The Body Shop serves the university as a fitness center and also as a wellness…
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Use of Optical Mapping in Bacterial Genome Finishing
DOE Office of Scientific and Technical Information (OSTI.GOV)
Kumar, Dibyendu
2010-06-03
Dibyendu Kumar from the University of Florida discusses whole-genome optical mapping to help validate bacterial genome assemblies on June 3, 2010 at the "Sequencing, Finishing, Analysis in the Future" meeting in Santa Fe, NM.
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Federal Register 2010, 2011, 2012, 2013, 2014
2011-02-22
... DEPARTMENT OF COMMERCE International Trade Administration Stanford University, et al.; Notice of... Constitution Avenue., NW., Washington, DC. Docket Number: 10-070. Applicant: Stanford University, Stanford CA... notice at 76 FR 2647, January 14, 2011. Docket Number: 10-071. Applicant: Stanford University, Stanford...
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Federal Register 2010, 2011, 2012, 2013, 2014
2013-12-23
... DEPARTMENT OF COMMERCE International Trade Administration University of Virginia, et al.; Notice... Constitution Avenue NW., Washington, DC. Docket Number: 13-025. Applicant: University of Virginia.... Intended Use: See notice at 78 FR 52760, August 26, 2013. Docket Number: 13-026. Applicant: Yale University...
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EUPAN enables pan-genome studies of a large number of eukaryotic genomes.
Hu, Zhiqiang; Sun, Chen; Lu, Kuang-Chen; Chu, Xixia; Zhao, Yue; Lu, Jinyuan; Shi, Jianxin; Wei, Chaochun
2017-08-01
Pan-genome analyses are routinely carried out for bacteria to interpret the within-species gene presence/absence variations (PAVs). However, pan-genome analyses are rare for eukaryotes due to the large sizes and higher complexities of their genomes. Here we proposed EUPAN, a eukaryotic pan-genome analysis toolkit, enabling automatic large-scale eukaryotic pan-genome analyses and detection of gene PAVs at a relatively low sequencing depth. In the previous studies, we demonstrated the effectiveness and high accuracy of EUPAN in the pan-genome analysis of 453 rice genomes, in which we also revealed widespread gene PAVs among individual rice genomes. Moreover, EUPAN can be directly applied to the current re-sequencing projects primarily focusing on single nucleotide polymorphisms. EUPAN is implemented in Perl, R and C ++. It is supported under Linux and preferred for a computer cluster with LSF and SLURM job scheduling system. EUPAN together with its standard operating procedure (SOP) is freely available for non-commercial use (CC BY-NC 4.0) at http://cgm.sjtu.edu.cn/eupan/index.html . ccwei@sjtu.edu.cn or jianxin.shi@sjtu.edu.cn. Supplementary data are available at Bioinformatics online. © The Author (2017). Published by Oxford University Press. All rights reserved. For Permissions, please email: journals.permissions@oup.com
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2012-10-17
may also be of great interest for further study in goats , which are host to the closely related caprine encephalitis arthritis virus. Materials and...the farm crews at Washington State University, ADRU, and USSES for technical assistance. The genotyping of TMEM154 diplotypes was performed at USMARC...of lentiviral species in sheep and goats with cumulative evidence of cross species transmission. Curr HIV Res 8: 94–100. 2. Blacklaws B, Harkiss GD
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29 CFR 2.2 - Employees attached to Washington office.
Code of Federal Regulations, 2013 CFR
2013-07-01
... 29 Labor 1 2013-07-01 2013-07-01 false Employees attached to Washington office. 2.2 Section 2.2 Labor Office of the Secretary of Labor GENERAL REGULATIONS General § 2.2 Employees attached to Washington office. No person who has been an employee of the Department and attached to the Washington office...
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29 CFR 2.2 - Employees attached to Washington office.
Code of Federal Regulations, 2014 CFR
2014-07-01
... 29 Labor 1 2014-07-01 2013-07-01 true Employees attached to Washington office. 2.2 Section 2.2 Labor Office of the Secretary of Labor GENERAL REGULATIONS General § 2.2 Employees attached to Washington office. No person who has been an employee of the Department and attached to the Washington office...
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29 CFR 2.2 - Employees attached to Washington office.
Code of Federal Regulations, 2010 CFR
2010-07-01
... 29 Labor 1 2010-07-01 2010-07-01 true Employees attached to Washington office. 2.2 Section 2.2 Labor Office of the Secretary of Labor GENERAL REGULATIONS General § 2.2 Employees attached to Washington office. No person who has been an employee of the Department and attached to the Washington office...
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29 CFR 2.2 - Employees attached to Washington office.
Code of Federal Regulations, 2011 CFR
2011-07-01
... 29 Labor 1 2011-07-01 2011-07-01 false Employees attached to Washington office. 2.2 Section 2.2 Labor Office of the Secretary of Labor GENERAL REGULATIONS General § 2.2 Employees attached to Washington office. No person who has been an employee of the Department and attached to the Washington office...
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29 CFR 2.2 - Employees attached to Washington office.
Code of Federal Regulations, 2012 CFR
2012-07-01
... 29 Labor 1 2012-07-01 2012-07-01 false Employees attached to Washington office. 2.2 Section 2.2 Labor Office of the Secretary of Labor GENERAL REGULATIONS General § 2.2 Employees attached to Washington office. No person who has been an employee of the Department and attached to the Washington office...
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12 CFR 4.4 - Washington office and web site.
Code of Federal Regulations, 2013 CFR
2013-01-01
... 12 Banks and Banking 1 2013-01-01 2013-01-01 false Washington office and web site. 4.4 Section 4.4... EXAMINERS Organization and Functions § 4.4 Washington office and web site. The Washington office of the OCC...'s Web site is at http://www.occ.gov. [76 FR 43561, July 21, 2011] ...
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12 CFR 4.4 - Washington office and web site.
Code of Federal Regulations, 2014 CFR
2014-01-01
... 12 Banks and Banking 1 2014-01-01 2014-01-01 false Washington office and web site. 4.4 Section 4.4... EXAMINERS Organization and Functions § 4.4 Washington office and web site. The Washington office of the OCC...'s Web site is at http://www.occ.gov. [76 FR 43561, July 21, 2011] ...
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12 CFR 4.4 - Washington office and web site.
Code of Federal Regulations, 2012 CFR
2012-01-01
... 12 Banks and Banking 1 2012-01-01 2012-01-01 false Washington office and web site. 4.4 Section 4.4... EXAMINERS Organization and Functions § 4.4 Washington office and web site. The Washington office of the OCC...'s Web site is at http://www.occ.gov. [76 FR 43561, July 21, 2011] ...
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30 CFR 947.700 - Washington Federal program.
Code of Federal Regulations, 2010 CFR
2010-07-01
....700 Mineral Resources OFFICE OF SURFACE MINING RECLAMATION AND ENFORCEMENT, DEPARTMENT OF THE INTERIOR PROGRAMS FOR THE CONDUCT OF SURFACE MINING OPERATIONS WITHIN EACH STATE WASHINGTON § 947.700 Washington Federal program. (a) This part contains all rules that are applicable to surface coal mining operations in...
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Ellis, L B; Hershberger, C D; Wackett, L P
1999-01-01
The University of Minnesota Biocatalysis/Biodegradation Database (UM-BBD, http://www.labmed.umn.edu/umbbd/i nde x.html) first became available on the web in 1995 to provide information on microbial biocatalytic reactions of, and biodegradation pathways for, organic chemical compounds, especially those produced by man. Its goal is to become a representative database of biodegradation, spanning the diversity of known microbial metabolic routes, organic functional groups, and environmental conditions under which biodegradation occurs. The database can be used to enhance understanding of basic biochemistry, biocatalysis leading to speciality chemical manufacture, and biodegradation of environmental pollutants. It is also a resource for functional genomics, since it contains information on enzymes and genes involved in specialized metabolism not found in intermediary metabolism databases, and thus can assist in assigning functions to genes homologous to such less common genes. With information on >400 reactions and compounds, it is poised to become a resource for prediction of microbial biodegradation pathways for compounds it does not contain, a process complementary to predicting the functions of new classes of microbial genes. PMID:9847233
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ERIC Educational Resources Information Center
Harvey, James; Rainey, Lydia
2006-01-01
Bringing charters to scale remains a major challenge. To learn more about barriers to the expansion of high-quality public charter schools and how they might be removed, the National Charter School Research Project (NCSRP) at the University of Washington and the National Alliance for Public Charter Schools convened a meeting of leaders from…
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2000-10-06
The White House, the Jefferson Memorial, and the Washington Monument with its shadow are all visible in this image of Washington, D.C. With its 15-meter spatial resolution, ASTER can see individual buildings. Taken on June 1, 2000, this image covers an area 14 kilometers (8.5 miles) wide and 13.7 kilometers (8.2 miles) long in three bands of the reflected visible and infrared wavelength region. The combination of visible and near infrared bands displays vegetation in red and water in dark grays. The Potomac River flows from the middle left to the bottom center. The large red area west of the river is Arlington National Cemetery. http://photojournal.jpl.nasa.gov/catalog/PIA02655
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A Plant-Associated Microbe Genome Initiative
DOE Office of Scientific and Technical Information (OSTI.GOV)
Jan E. Leach; Scott Gold; Sue Tolin
2003-03-06
Plant-associated microorganisms are critical to agricultural and food security and are key components in maintaining the balance of our ecosystems. Some of these diverse microbes, which include viruses, bacteria, oomycetes, fungi, and nematodes, cause plant diseases, whereas others prevent diseases or enhance plant growth. Despite their importance, we know little about them on a genomic level. To intervene in disease and understand the basis of biological control or symbiotic relationships, a concerted and coordinated genomic analysis of these microbes is essential. Genome analysis, in this context, refers to the structural and functional analysis of the microbe DNA including the genes,more » the proteins encoded by those genes, as well as noncoding sequences involved in genome dynamics and function. The ultimate emphasis is on understanding genomic functions involved in plant associations. Members of The American Phytopathological Society (APS) developed a prioritized list of plant-associated microbes for genome analysis. With this list as a foundation for discussions, a Workshop on Genomic Analysis of Plant-Associated Microorganisms was held in Washington, D.C., on 9 to 11 April 2002. The workshop was organized by the Public Policy Board of APS, and was funded by the Department of Energy (DOE), the National Science Foundation (NSF), U.S. Department of Agriculture-Agricultural Research Service (USDA-ARS), and USDA-National Research Initiatives (USDA-NRI). The workshop included academic, industrial, and governmental experts from the genomics and microbial research communities and observers from the federal funding agencies. After reviewing current and near-term technologies, workshop participants proposed a comprehensive, international initiative to obtain the genomic information needed to understand these important microbes and their interactions with host plants and the environment. Specifically, the recommendations call for a 5-year, $500 million international
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The Language of the Protein Universe
Scaiewicz, Andrea; Levitt, Michael
2015-01-01
Proteins, the main cell machinery which play a major roll in nearly every cellular process, have always been a central focus in biology. We live in the post-genomic era, and inferring information from massive data sets is a steadily growing universal challenge. The increasing availability of fully sequenced genomes can be regarded as the “Rosetta Stone” of the protein universe, allowing the understanding of genomes and their evolution, just as the original Rosetta Stone allowed Champollion to decipher the ancient Egyptian hieroglyphics. In this review, we consider aspects of the protein domain architectures repertoire that are closely related to those of human languages and aim to provide some insights about the language of proteins. PMID:26451980
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Gao, Guangtu; Nome, Torfinn; Pearse, Devon E; Moen, Thomas; Naish, Kerry A; Thorgaard, Gary H; Lien, Sigbjørn; Palti, Yniv
2018-01-01
Single-nucleotide polymorphisms (SNPs) are highly abundant markers, which are broadly distributed in animal genomes. For rainbow trout ( Oncorhynchus mykiss ), SNP discovery has been previously done through sequencing of restriction-site associated DNA (RAD) libraries, reduced representation libraries (RRL) and RNA sequencing. Recently we have performed high coverage whole genome resequencing with 61 unrelated samples, representing a wide range of rainbow trout and steelhead populations, with 49 new samples added to 12 aquaculture samples from AquaGen (Norway) that we previously used for SNP discovery. Of the 49 new samples, 11 were double-haploid lines from Washington State University (WSU) and 38 represented wild and hatchery populations from a wide range of geographic distribution and with divergent migratory phenotypes. We then mapped the sequences to the new rainbow trout reference genome assembly (GCA_002163495.1) which is based on the Swanson YY doubled haploid line. Variant calling was conducted with FreeBayes and SAMtools mpileup , followed by filtering of SNPs based on quality score, sequence complexity, read depth on the locus, and number of genotyped samples. Results from the two variant calling programs were compared and genotypes of the double haploid samples were used for detecting and filtering putative paralogous sequence variants (PSVs) and multi-sequence variants (MSVs). Overall, 30,302,087 SNPs were identified on the rainbow trout genome 29 chromosomes and 1,139,018 on unplaced scaffolds, with 4,042,723 SNPs having high minor allele frequency (MAF > 0.25). The average SNP density on the chromosomes was one SNP per 64 bp, or 15.6 SNPs per 1 kb. Results from the phylogenetic analysis that we conducted indicate that the SNP markers contain enough population-specific polymorphisms for recovering population relationships despite the small sample size used. Intra-Population polymorphism assessment revealed high level of polymorphism and heterozygosity
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ERIC Educational Resources Information Center
Dashiell, Dick
Membership, finances, general fund budgets, collective bargaining, state conferences, the Equal Rights Amendment, public school science, salaries, censure, the Moynihan award, and the Reagan budget cuts were addressed at the 67th Annual Meeting of the American Association of University Professors (AAUP). The Reagan Administration's proposed budget…
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Evolution of genome size and genomic GC content in carnivorous holokinetics (Droseraceae).
Veleba, Adam; Šmarda, Petr; Zedek, František; Horová, Lucie; Šmerda, Jakub; Bureš, Petr
2017-02-01
Studies in the carnivorous family Lentibulariaceae in the last years resulted in the discovery of the smallest plant genomes and an unusual pattern of genomic GC content evolution. However, scarcity of genomic data in other carnivorous clades still prevents a generalization of the observed patterns. Here the aim was to fill this gap by mapping genome evolution in the second largest carnivorous family, Droseraceae, where this evolution may be affected by chromosomal holokinetism in Drosera METHODS: The genome size and genomic GC content of 71 Droseraceae species were measured by flow cytometry. A dated phylogeny was constructed, and the evolution of both genomic parameters and their relationship to species climatic niches were tested using phylogeny-based statistics. The 2C genome size of Droseraceae varied between 488 and 10 927 Mbp, and the GC content ranged between 37·1 and 44·7 %. The genome sizes and genomic GC content of carnivorous and holocentric species did not differ from those of their non-carnivorous and monocentric relatives. The genomic GC content positively correlated with genome size and annual temperature fluctuations. The genome size and chromosome numbers were inversely correlated in the Australian clade of Drosera CONCLUSIONS: Our results indicate that neither carnivory (nutrient scarcity) nor the holokinetism have a prominent effect on size and DNA base composition of Droseraceae genomes. However, the holokinetic drive seems to affect karyotype evolution in one of the major clades of Drosera Our survey confirmed that the evolution of GC content is tightly connected with the evolution of genome size and also with environmental conditions. © The Author 2016. Published by Oxford University Press on behalf of the Annals of Botany Company. All rights reserved. For Permissions, please email: journals.permissions@oup.com.
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Father Secchi Goes to Washington
NASA Astrophysics Data System (ADS)
McCarthy, M. F.
1994-12-01
In 1848 a small group of Jesuit refugees arrived at Georgetown College near Washington, D.C. Among them was a young priest, Angelo Secchi, who had finished theology studies in Rome, but had not been able to complete his final examinations. This done successfully, Secchi turned to astronomy and the new facilities of the Georgetown College Observatory, directed by its founder, Fr. James Curley. During his two years in Washington, Secchi studied physics, wrote an article on Electrical Rheometry for the Smithsonian Institution, and formed a friendship with Matthew Fontaine Maury of the U.S. Navy, who headed the Chart Service and in 1844 was named superintendent of the National Observatory. This was later named the U.S. Naval Observatory. Secchi's friendships formed during the Washington visit proved most helpful for relations between European astronomers and U.S. colleagues. Secchi, after his return to Rome constructed the Observatory of the Collegio Romano atop the baroque Church of St. Ignatius in Rome and began his work in spectral classification of stars.
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Washington State Survey of Adolescent Health Behaviors.
ERIC Educational Resources Information Center
Washington State Dept. of Social and Health Services, Olympia.
The 1992 Washington State Survey of Adolescent Health Behaviors (WSSAHB) was created to collect information regarding a variety of adolescent health behaviors among students in the state of Washington. It expands on two previous administrations of a student tobacco, alcohol, and other drug survey and includes questions about medical care, safety,…
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Aerospace Training. Washington's Community and Technical Colleges
ERIC Educational Resources Information Center
Washington State Board for Community and Technical Colleges, 2014
2014-01-01
Aerospace is an economic powerhouse that generates jobs and fuels our economy. Washington's community and technical colleges produce the world-class employees needed to keep it that way. With about 1,250 aerospace-related firms employing more than 94,000 workers, Washington has the largest concentration of aerospace expertise in the nation. To…
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Corrections Education. Washington's Community and Technical Colleges
ERIC Educational Resources Information Center
Washington State Board for Community and Technical Colleges, 2015
2015-01-01
The Washington State Department of Corrections contracts with community colleges to provide basic education and job training at each of the state's 12 adult prisons so upon release, individuals are more likely to get jobs and less likely to return. Washington State community colleges build a bridge for offenders to successfully re-enter…
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Community & Technical College Share of Washington's Educational Attainment Goals for 2023
ERIC Educational Resources Information Center
Washington State Board for Community and Technical Colleges, 2015
2015-01-01
In 2013, the Washington Student Achievement Council (WSAC) set a 10 year plan for improving the educational attainment of Washington residents. The Roadmap included two educational attainment goals for 2023: (1) All adults in Washington, ages 25-44, will have a high school diploma or equivalent; and (2) At least 70 percent of Washington adults,…
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78 FR 46258 - Drawbridge Operation Regulation Lake Washington, Seattle, WA
Federal Register 2010, 2011, 2012, 2013, 2014
2013-07-31
... Operation Regulation Lake Washington, Seattle, WA AGENCY: Coast Guard, DHS. ACTION: Notice of deviation from... that governs the Evergreen Point Floating Bridge (State Route 520 across Lake Washington) at Seattle... Route 520 across Lake Washington) remain closed to vessel traffic to facilitate safe passage of...
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State of Washington Population Trends, 1977. Washington State Information Report.
ERIC Educational Resources Information Center
Washington State Office of Program Planning and Fiscal Management, Olympia.
As of April 1, 1977, Washington's population was estimated at 3,661,975--an increase of 248,725 since 1970. Prepared yearly, this report presents data on the official April 1 population estimates for cities, towns, and counties; components of population change; planned population forecasting activities; procedures which help make the housing unit…
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A Universal Genome Array and Transcriptome Atlas for Brachypodium Distachyon
DOE Office of Scientific and Technical Information (OSTI.GOV)
Mockler, Todd
Brachypodium distachyon is the premier experimental model grass platform and is related to candidate feedstock crops for bioethanol production. Based on the DOE-JGI Brachypodium Bd21 genome sequence and annotation we designed a whole genome DNA microarray platform. The quality of this array platform is unprecedented due to the exceptional quality of the Brachypodium genome assembly and annotation and the stringent probe selection criteria employed in the design. We worked with members of the international community and the bioinformatics/design team at Affymetrix at all stages in the development of the array. We used the Brachypodium arrays to interrogate the transcriptomes ofmore » plants grown in a variety of environmental conditions including diurnal and circadian light/temperature conditions and under a variety of environmental conditions. We examined the transciptional responses of Brachypodium seedlings subjected to various abiotic stresses including heat, cold, salt, and high intensity light. We generated a gene expression atlas representing various organs and developmental stages. The results of these efforts including all microarray datasets are published and available at online public databases.« less
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A Genome-Wide Landscape of Retrocopies in Primate Genomes.
Navarro, Fábio C P; Galante, Pedro A F
2015-07-29
Gene duplication is a key factor contributing to phenotype diversity across and within species. Although the availability of complete genomes has led to the extensive study of genomic duplications, the dynamics and variability of gene duplications mediated by retrotransposition are not well understood. Here, we predict mRNA retrotransposition and use comparative genomics to investigate their origin and variability across primates. Analyzing seven anthropoid primate genomes, we found a similar number of mRNA retrotranspositions (∼7,500 retrocopies) in Catarrhini (Old Word Monkeys, including humans), but a surprising large number of retrocopies (∼10,000) in Platyrrhini (New World Monkeys), which may be a by-product of higher long interspersed nuclear element 1 activity in these genomes. By inferring retrocopy orthology, we dated most of the primate retrocopy origins, and estimated a decrease in the fixation rate in recent primate history, implying a smaller number of species-specific retrocopies. Moreover, using RNA-Seq data, we identified approximately 3,600 expressed retrocopies. As expected, most of these retrocopies are located near or within known genes, present tissue-specific and even species-specific expression patterns, and no expression correlation to their parental genes. Taken together, our results provide further evidence that mRNA retrotransposition is an active mechanism in primate evolution and suggest that retrocopies may not only introduce great genetic variability between lineages but also create a large reservoir of potentially functional new genomic loci in primate genomes. © The Author(s) 2015. Published by Oxford University Press on behalf of the Society for Molecular Biology and Evolution.
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75 FR 73073 - Washington Gas Light Company; Notice of Filing
Federal Register 2010, 2011, 2012, 2013, 2014
2010-11-29
... DEPARTMENT OF ENERGY Federal Energy Regulatory Commission [Docket No. PR11-74-000] Washington Gas Light Company; Notice of Filing November 18, 2010. Take notice that on November 15, 2010, Washington Gas Light Company (Washington Gas) filed its annual actual lost and unaccounted for volumes (LAUF...
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76 FR 26719 - Washington 10 Storage Corporation; Notice of Filing
Federal Register 2010, 2011, 2012, 2013, 2014
2011-05-09
... DEPARTMENT OF ENERGY Federal Energy Regulatory Commission [Docket No. PR11-80-001] Washington 10 Storage Corporation; Notice of Filing Take notice that on April 29, 2011, Washington 10 Storage Corporation (Washington 10) filed a revised Statement of Operating Conditions (SOC) to comply with an April 25...
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76 FR 78915 - Washington 10 Storage Corporation; Notice of Filing
Federal Register 2010, 2011, 2012, 2013, 2014
2011-12-20
... DEPARTMENT OF ENERGY Federal Energy Regulatory Commission [Docket No. PR12-10-000] Washington 10 Storage Corporation; Notice of Filing Take notice that on December 13, 2011, Washington 10 Storage Corporation (Washington 10) filed a Statement of Operating Conditions to revise certain provisions of its Firm...
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During World War 1, The American University in Washington D.C. was used by the U.S. Army as an experiment station for the development and testing of a variety of battlefield munitions including chemical weapons such as Mustard Gas, Phosgene, Ricin and Lewisite, among others. Afte...
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School-to-Work Collaboration: University and Public Schools.
ERIC Educational Resources Information Center
Cristol, Dean S.
This document contains six papers from a collaborative school-to-work project during which teacher education faculty at Bowling Green State University worked with faculty and staff at Washington Local Schools in Toledo, Ohio, to infuse school-to-work activities within the context of each participating teacher's content area. "Employability…
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Federal Register 2010, 2011, 2012, 2013, 2014
2012-08-30
... DEPARTMENT OF COMMERCE International Trade Administration University of Wisconsin--Madison, et al... Constitution Avenue NW., Washington, DC Docket Number: 12-026. Applicant: University of Wisconsin--Madison, Madison, WI 53715-1218. Instrument: Electron Microscope. Manufacturer: FEI [[Page 52682
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ERIC Educational Resources Information Center
Hughey, Matthew W.
2006-01-01
On March 2, 1867, the Historically Black College or University (HBCU) Howard University (HU) was founded in Washington, D. C. Almost exactly one year later, the all white fraternity of Pi Kappa Alpha was founded at the University of Virginia. Over 100 years later, on February 18 2006, fifty-five HU students became charter members of Pi Kappa Alpha…
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The language of the protein universe.
Scaiewicz, Andrea; Levitt, Michael
2015-12-01
Proteins, the main cell machinery which play a major role in nearly every cellular process, have always been a central focus in biology. We live in the post-genomic era, and inferring information from massive data sets is a steadily growing universal challenge. The increasing availability of fully sequenced genomes can be regarded as the 'Rosetta Stone' of the protein universe, allowing the understanding of genomes and their evolution, just as the original Rosetta Stone allowed Champollion to decipher the ancient Egyptian hieroglyphics. In this review, we consider aspects of the protein domain architectures repertoire that are closely related to those of human languages and aim to provide some insights about the language of proteins. Copyright © 2015 Elsevier Ltd. All rights reserved.
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A GSC Global Genome Census (GSC8 Meeting)
Kyrpides, Nikos
2018-01-15
The Genomic Standards Consortium was formed in September 2005. It is an international, open-membership working body which promotes standardization in the description of genomes and the exchange and integration of genomic data. The 2009 meeting was an activity of a five-year funding "Research Coordination Network" from the National Science Foundation and was organized held at the DOE Joint Genome Institute with organizational support provided by the JGI and by the University of California - San Diego. Nikos Kyrpides of the DOE Joint Genome Institute discusses the notion of a global genome census at the Genomic Standards Consortium's 8th meeting at the DOE JGI in Walnut Creek, CA on Sept. 9, 2009.
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Alcohol Policies and Practices on College and University Campuses. NASPA Monograph Series Volume 7.
ERIC Educational Resources Information Center
Sherwood, Joan S., Ed.
Following the alcohol-related death of a student at Western Washington University in 1984, the National Association of Student Personnel Administrators (NASPA), initiated a study of guidelines for dealing with alcohol on college and university campuses nationwide. Suggestions are made for establishing effective policies and opening lines of…
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75 FR 53964 - Washington Gas Light Company; Notice of Filing
Federal Register 2010, 2011, 2012, 2013, 2014
2010-09-02
... DEPARTMENT OF ENERGY Federal Energy Regulatory Commission [Docket No. PR09-8-004] Washington Gas Light Company; Notice of Filing August 27, 2010. Take notice that on August 24, 2010, Washington Gas Light Company (Washington Gas) filed to revise the Statement of Interstate Service Rates of its Firm...
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Reshaping the Image of Booker T. Washington
ERIC Educational Resources Information Center
Norrell, Robert J.
2009-01-01
Booker T. Washington, founder of the Tuskegee Institute and the recognized leader of American black people from 1895 until his death in 1915, has been viewed as an accommodationist to segregation, an African-American leader who traded black equality and voting rights for his own influence among white bigots. Washington rose to national fame with a…
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Early Childhood Injury Deaths in Washington State.
ERIC Educational Resources Information Center
Starzyk, Patricia M.
This paper discusses data on the deaths of children aged 1-4 years in Washington State. A two-fold approach was used in the analysis. First, Washington State death certificate data for 1979-85 were used to characterize the deaths and identify hazardous situations. Second, death certificates were linked to birth certificates of children born in…
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76 FR 377 - Land Acquisitions; Cowlitz Indian Tribe of Washington
Federal Register 2010, 2011, 2012, 2013, 2014
2011-01-04
... State of Washington by Auditor's File Nos. G 450664 and G 147358. Parcel II That portion of the... thereof acquired by the State of Washington by deed recorded under Auditor's File Nos. G 140380 and D... recorded under Auditor's File No. F 38759, records of Clark County, Washington, described as follows...
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Population trajectory of burrowing owls (Athene cunicularia) in eastern Washington
Conway, C.J.; Pardieck, K.L.
2006-01-01
Anecdotal evidence suggests that burrowing owls have declined in Washington. The Washington Department of Fish and Wildlife is currently conducting a status review for burrowing owls which will help determine whether they should be listed as threatened or endangered in the state. To provide insights into the current status of burrowing owls (Athene cunicularia), we analyzed data from the North American Breeding Bird Survey using two analytical approaches to determine their current population trajectory in eastern Washington. We used a one-sample t-test to examine whether trend estimates across all BBS routes in Washington differed from zero. We also used a mixed model analysis to estimate the rate of decline in number of burrowing owls detected between 1968 and 2005. The slope in number of burrowing owls detected was negative for 12 of the 16 BBS routes in Washington that have detected burrowing owls. Numbers of breeding burrowing owls detected in eastern Washington declined at a rate of 1.5% annually. We suggest that all BBS routes that have detected burrowing owls in past years in eastern Washington be surveyed annually and additional surveys conducted to track population trends of burrowing owls at finer spatial scales in eastern Washington. In the meantime, land management and regulatory agencies should ensure that publicly managed areas with breeding burrowing owls are not degraded and should implement education and outreach programs to promote protection of privately owned areas with breeding owls.
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Banks, Jody
2018-02-12
Jody Banks from Purdue University on "The Genome of Selaginella, a Remnant of an Ancient Vascular Plant Lineage" at the 7th Annual Genomics of Energy & Environment Meeting on March 21, 2012 in Walnut Creek, Calif.
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Kaeppler, Shawn
2018-02-01
Shawn Kaeppler from the University of Wisconsin-Madison on "Genomic Analysis of Biofuel Traits in Maize and Switchgrass" at the 7th Annual Genomics of Energy & Environment Meeting on March 21, 2012 in Walnut Creek, CA.
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David Haussler, Ph.D., Lectures on Cancer Genomics - TCGA
In this lecture, Dr. David Haussler provides a historical overview of the field of genomics leading up to TCGA, including the Cancer Genomics Hub at the University of California, Santa Cruz, and the TCGA Pan-Cancer initiative.
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Dr. Marco Marra: Pioneer and Visionary in Cancer Genomics Research | Office of Cancer Genomics
Dr. Marco Marra is a highly distinguished genomics and bioinformatics researcher. He is the Director of Canada’s Michael Smith Genome Sciences Centre at the BC Cancer Agency and holds a faculty position at the University of British Columbia. The Centre is a state-of-the-art sequencing facility in Vancouver, Canada, with a major focus on the study of cancers. Many of their research projects are undertaken in collaborations with other Canadian and international institutions.
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An Exploration into Fern Genome Space.
Wolf, Paul G; Sessa, Emily B; Marchant, Daniel Blaine; Li, Fay-Wei; Rothfels, Carl J; Sigel, Erin M; Gitzendanner, Matthew A; Visger, Clayton J; Banks, Jo Ann; Soltis, Douglas E; Soltis, Pamela S; Pryer, Kathleen M; Der, Joshua P
2015-08-26
Ferns are one of the few remaining major clades of land plants for which a complete genome sequence is lacking. Knowledge of genome space in ferns will enable broad-scale comparative analyses of land plant genes and genomes, provide insights into genome evolution across green plants, and shed light on genetic and genomic features that characterize ferns, such as their high chromosome numbers and large genome sizes. As part of an initial exploration into fern genome space, we used a whole genome shotgun sequencing approach to obtain low-density coverage (∼0.4X to 2X) for six fern species from the Polypodiales (Ceratopteris, Pteridium, Polypodium, Cystopteris), Cyatheales (Plagiogyria), and Gleicheniales (Dipteris). We explore these data to characterize the proportion of the nuclear genome represented by repetitive sequences (including DNA transposons, retrotransposons, ribosomal DNA, and simple repeats) and protein-coding genes, and to extract chloroplast and mitochondrial genome sequences. Such initial sweeps of fern genomes can provide information useful for selecting a promising candidate fern species for whole genome sequencing. We also describe variation of genomic traits across our sample and highlight some differences and similarities in repeat structure between ferns and seed plants. © The Author(s) 2015. Published by Oxford University Press on behalf of the Society for Molecular Biology and Evolution.
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State of Washington Population Trends, 1975. Washington State Information Report.
ERIC Educational Resources Information Center
Washington State Office of Program Planning and Fiscal Management, Olympia.
As of April 1, 1975, Washington's population was estimated at 3,494,124--an increase of 80,874 since 1970. Prepared yearly, this report presents tabular data pertaining to: (1) current April 1 estimates for cities, towns, and counties; (2) current decline in household size; (3) the use of postal vacancy surveys in estimating vacancy rates; and (4)…
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The Growing Influence of the Government on the Affairs of the University. A Self Study.
ERIC Educational Resources Information Center
George Washington Univ., Washington, DC.
A self-study conducted by George Washington University on the influence of the government on university affairs considered the following areas: (1) civil rights legislation and compliance; (2) legislation other than civil rights requiring compliance (e.g., occupational safety); (3) government program funding priorities; and (4) funds…
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Microbial genome analysis: the COG approach.
Galperin, Michael Y; Kristensen, David M; Makarova, Kira S; Wolf, Yuri I; Koonin, Eugene V
2017-09-14
For the past 20 years, the Clusters of Orthologous Genes (COG) database had been a popular tool for microbial genome annotation and comparative genomics. Initially created for the purpose of evolutionary classification of protein families, the COG have been used, apart from straightforward functional annotation of sequenced genomes, for such tasks as (i) unification of genome annotation in groups of related organisms; (ii) identification of missing and/or undetected genes in complete microbial genomes; (iii) analysis of genomic neighborhoods, in many cases allowing prediction of novel functional systems; (iv) analysis of metabolic pathways and prediction of alternative forms of enzymes; (v) comparison of organisms by COG functional categories; and (vi) prioritization of targets for structural and functional characterization. Here we review the principles of the COG approach and discuss its key advantages and drawbacks in microbial genome analysis. Published by Oxford University Press 2017. This work is written by US Government employees and is in the public domain in the US.
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78 FR 39591 - Drawbridge Operation Regulation; Lake Washington Ship Canal at Seattle, WA
Federal Register 2010, 2011, 2012, 2013, 2014
2013-07-02
...The Coast Guard has issued a temporary deviation from the operating schedule that governs three Seattle Department of Transportation (SDOT) bridges: The Ballard Bridge, mile 1.1, the Fremont Bridge, mile 2.6, and the University Bridge, mile 4.3, all crossing the Lake Washington Ship Canal at Seattle, WA. The deviation is necessary to accommodate heavier than normal roadway traffic associated with a fireworks display over Lake Union. This deviation allows the bridges to remain in the closed position immediately prior to until immediately after the fireworks display.
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WhopGenome: high-speed access to whole-genome variation and sequence data in R.
Wittelsbürger, Ulrich; Pfeifer, Bastian; Lercher, Martin J
2015-02-01
The statistical programming language R has become a de facto standard for the analysis of many types of biological data, and is well suited for the rapid development of new algorithms. However, variant call data from population-scale resequencing projects are typically too large to be read and processed efficiently with R's built-in I/O capabilities. WhopGenome can efficiently read whole-genome variation data stored in the widely used variant call format (VCF) file format into several R data types. VCF files can be accessed either on local hard drives or on remote servers. WhopGenome can associate variants with annotations such as those available from the UCSC genome browser, and can accelerate the reading process by filtering loci according to user-defined criteria. WhopGenome can also read other Tabix-indexed files and create indices to allow fast selective access to FASTA-formatted sequence files. The WhopGenome R package is available on CRAN at http://cran.r-project.org/web/packages/WhopGenome/. A Bioconductor package has been submitted. lercher@cs.uni-duesseldorf.de. © The Author 2014. Published by Oxford University Press. All rights reserved. For Permissions, please e-mail: journals.permissions@oup.com.
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Federal Register 2010, 2011, 2012, 2013, 2014
2011-09-12
... DEPARTMENT OF COMMERCE International Trade Administration Brandeis University, et al.; Notice of Consolidated Decision on Applications for Duty-Free Entry of Electron Microscope This is a decision... Constitution Avenue, NW., Washington, DC. Docket Number: 11-042. Applicant: Brandeis University, Waltham, MA...
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Managing Change in a Research University Special Education Program.
ERIC Educational Resources Information Center
Affleck, James Q.; Lowenbraun, Sheila
1995-01-01
This article describes the restructuring of the Special Education Teacher Education program at the University of Washington. Analysis indicated a paradigm shift as well as intense collaborative activity and significant programmatic and curricular modifications. Descriptions of the type of personnel needed in the new program are offered, and goals…
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Wang, Linhai; Yu, Jingyin; Li, Donghua; Zhang, Xiurong
2015-01-01
Sesame (Sesamum indicum L.) is an ancient and important oilseed crop grown widely in tropical and subtropical areas. It belongs to the gigantic order Lamiales, which includes many well-known or economically important species, such as olive (Olea europaea), leonurus (Leonurus japonicus) and lavender (Lavandula spica), many of which have important pharmacological properties. Despite their importance, genetic and genomic analyses on these species have been insufficient due to a lack of reference genome information. The now available S. indicum genome will provide an unprecedented opportunity for studying both S. indicum genetic traits and comparative genomics. To deliver S. indicum genomic information to the worldwide research community, we designed Sinbase, a web-based database with comprehensive sesame genomic, genetic and comparative genomic information. Sinbase includes sequences of assembled sesame pseudomolecular chromosomes, protein-coding genes (27,148), transposable elements (372,167) and non-coding RNAs (1,748). In particular, Sinbase provides unique and valuable information on colinear regions with various plant genomes, including Arabidopsis thaliana, Glycine max, Vitis vinifera and Solanum lycopersicum. Sinbase also provides a useful search function and data mining tools, including a keyword search and local BLAST service. Sinbase will be updated regularly with new features, improvements to genome annotation and new genomic sequences, and is freely accessible at http://ocri-genomics.org/Sinbase/. © The Author 2014. Published by Oxford University Press on behalf of Japanese Society of Plant Physiologists. All rights reserved. For permissions, please email: journals.permissions@oup.com.
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Getting Veterans Back to Work. Washington's Community and Technical Colleges
ERIC Educational Resources Information Center
Washington State Board for Community and Technical Colleges, 2015
2015-01-01
Each year about 13,000 military personnel leave the service and select Washington state as their home, bringing with them a wealth of experience and a wide range of skills. Washington ranks among the top five most popular states for military personnel separating from the service. Washington's 34 community and technical colleges are a perfect fit…
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Washington Play Fairway Analysis Geothermal GIS Data
Corina Forson
2015-12-15
This file contains file geodatabases of the Mount St. Helens seismic zone (MSHSZ), Wind River valley (WRV) and Mount Baker (MB) geothermal play-fairway sites in the Washington Cascades. The geodatabases include input data (feature classes) and output rasters (generated from modeling and interpolation) from the geothermal play-fairway in Washington State, USA. These data were gathered and modeled to provide an estimate of the heat and permeability potential within the play-fairways based on: mapped volcanic vents, hot springs and fumaroles, geothermometry, intrusive rocks, temperature-gradient wells, slip tendency, dilation tendency, displacement, displacement gradient, max coulomb shear stress, sigma 3, maximum shear strain rate, and dilational strain rate at 200m and 3 km depth. In addition this file contains layer files for each of the output rasters. For details on the areas of interest please see the 'WA_State_Play_Fairway_Phase_1_Technical_Report' in the download package. This submission also includes a file with the geothermal favorability of the Washington Cascade Range based off of an earlier statewide assessment. Additionally, within this file there are the maximum shear and dilational strain rate rasters for all of Washington State.
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Genome Variation Map: a data repository of genome variations in BIG Data Center.
Song, Shuhui; Tian, Dongmei; Li, Cuiping; Tang, Bixia; Dong, Lili; Xiao, Jingfa; Bao, Yiming; Zhao, Wenming; He, Hang; Zhang, Zhang
2018-01-04
The Genome Variation Map (GVM; http://bigd.big.ac.cn/gvm/) is a public data repository of genome variations. As a core resource in the BIG Data Center, Beijing Institute of Genomics, Chinese Academy of Sciences, GVM dedicates to collect, integrate and visualize genome variations for a wide range of species, accepts submissions of different types of genome variations from all over the world and provides free open access to all publicly available data in support of worldwide research activities. Unlike existing related databases, GVM features integration of a large number of genome variations for a broad diversity of species including human, cultivated plants and domesticated animals. Specifically, the current implementation of GVM not only houses a total of ∼4.9 billion variants for 19 species including chicken, dog, goat, human, poplar, rice and tomato, but also incorporates 8669 individual genotypes and 13 262 manually curated high-quality genotype-to-phenotype associations for non-human species. In addition, GVM provides friendly intuitive web interfaces for data submission, browse, search and visualization. Collectively, GVM serves as an important resource for archiving genomic variation data, helpful for better understanding population genetic diversity and deciphering complex mechanisms associated with different phenotypes. © The Author(s) 2017. Published by Oxford University Press on behalf of Nucleic Acids Research.
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R. James Cook; Robert L. Edmonds; Ned B. Klopfenstein; Willis Littke; Geral McDonald; Daniel Omdahl; Karen Ripley; Charles G. Shaw; Rona Sturrock; Paul Zambino
2013-01-01
This report from the Washington State Academy of Sciences (WSAS) is in response to a request from the Washington State Department of Natural Resources (DNR) to "identify approaches and opportunities ripe for research on understanding and managing root diseases of Douglas-fir." Similar to the process used by the National Research Council, the WSAS upon...
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36 CFR 1253.4 - Washington National Records Center.
Code of Federal Regulations, 2014 CFR
2014-07-01
... 36 Parks, Forests, and Public Property 3 2014-07-01 2014-07-01 false Washington National Records Center. 1253.4 Section 1253.4 Parks, Forests, and Public Property NATIONAL ARCHIVES AND RECORDS... National Records Center. Washington National Records Center is located at 4205 Suitland Road, Suitland, MD...
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36 CFR 1253.4 - Washington National Records Center.
Code of Federal Regulations, 2012 CFR
2012-07-01
... 36 Parks, Forests, and Public Property 3 2012-07-01 2012-07-01 false Washington National Records Center. 1253.4 Section 1253.4 Parks, Forests, and Public Property NATIONAL ARCHIVES AND RECORDS... National Records Center. Washington National Records Center is located at 4205 Suitland Road, Suitland, MD...
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36 CFR 1253.4 - Washington National Records Center.
Code of Federal Regulations, 2011 CFR
2011-07-01
... 36 Parks, Forests, and Public Property 3 2011-07-01 2011-07-01 false Washington National Records Center. 1253.4 Section 1253.4 Parks, Forests, and Public Property NATIONAL ARCHIVES AND RECORDS... National Records Center. Washington National Records Center is located at 4205 Suitland Road, Suitland, MD...
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The Saccharomyces Genome Database Variant Viewer.
Sheppard, Travis K; Hitz, Benjamin C; Engel, Stacia R; Song, Giltae; Balakrishnan, Rama; Binkley, Gail; Costanzo, Maria C; Dalusag, Kyla S; Demeter, Janos; Hellerstedt, Sage T; Karra, Kalpana; Nash, Robert S; Paskov, Kelley M; Skrzypek, Marek S; Weng, Shuai; Wong, Edith D; Cherry, J Michael
2016-01-04
The Saccharomyces Genome Database (SGD; http://www.yeastgenome.org) is the authoritative community resource for the Saccharomyces cerevisiae reference genome sequence and its annotation. In recent years, we have moved toward increased representation of sequence variation and allelic differences within S. cerevisiae. The publication of numerous additional genomes has motivated the creation of new tools for their annotation and analysis. Here we present the Variant Viewer: a dynamic open-source web application for the visualization of genomic and proteomic differences. Multiple sequence alignments have been constructed across high quality genome sequences from 11 different S. cerevisiae strains and stored in the SGD. The alignments and summaries are encoded in JSON and used to create a two-tiered dynamic view of the budding yeast pan-genome, available at http://www.yeastgenome.org/variant-viewer. © The Author(s) 2015. Published by Oxford University Press on behalf of Nucleic Acids Research.
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Reimagining the 21st-Century Land-Grant University
ERIC Educational Resources Information Center
Fischer, Karin
2009-01-01
Over the last two years, University of Georgia students and faculty members have worked with community leaders in Sandersville and surrounding Washington County to tackle some of the area's most pressing problems, among them, reversing a doctor shortage and improving air quality to meet federal standards. Their work is part of an effort, now in…
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Salawu, Abdulazeez; Ul-Hassan, Aliya; Hammond, David; Fernando, Malee; Reed, Malcolm; Sisley, Karen
2012-01-01
Most soft tissue sarcomas are characterized by genetic instability and frequent genomic copy number aberrations that are not subtype-specific. Oligonucleotide microarray-based Comparative Genomic Hybridisation (array CGH) is an important technique used to map genome-wide copy number aberrations, but the traditional requirement for high-quality DNA typically obtained from fresh tissue has limited its use in sarcomas. Although large archives of Formalin-fixed Paraffin-embedded (FFPE) tumour samples are available for research, the degradative effects of formalin on DNA from these tissues has made labelling and analysis by array CGH technically challenging. The Universal Linkage System (ULS) may be used for a one-step chemical labelling of such degraded DNA. We have optimised the ULS labelling protocol to perform aCGH on archived FFPE leiomyosarcoma tissues using the 180k Agilent platform. Preservation age of samples ranged from a few months to seventeen years and the DNA showed a wide range of degradation (when visualised on agarose gels). Consistently high DNA labelling efficiency and low microarray probe-to-probe variation (as measured by the derivative log ratio spread) was seen. Comparison of paired fresh and FFPE samples from identical tumours showed good correlation of CNAs detected. Furthermore, the ability to macro-dissect FFPE samples permitted the detection of CNAs that were masked in fresh tissue. Aberrations were visually confirmed using Fluorescence in situ Hybridisation. These results suggest that archival FFPE tissue, with its relative abundance and attendant clinical data may be used for effective mapping for genomic copy number aberrations in such rare tumours as leiomyosarcoma and potentially unravel clues to tumour origins, progression and ultimately, targeted treatment. PMID:23209738
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ERIC Educational Resources Information Center
Nisonger, Thomas E.
1983-01-01
Using random selection of citations from journal articles, two specific permutations of the citation checking approach to university library collection evaluation are tested on political science collections in five university libraries in the Washington, D.C. area. The history of the citation checking approach is reviewed. Forty-three references…
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ERIC Educational Resources Information Center
Payumo, Jane G.; Lan, George; Arasu, Prema
2018-01-01
This study offers a unique lens on the patterns, productivity, and impact of researcher mobility at a US research-intensive university. Bibliometric data for Washington State University (WSU) was extracted from Elsevier's Scopus database and analyzed for the 10-year period from 2002 to 2012. We grouped researchers into four categories based on…
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Implications of the Tribolium genome project for pest biology
USDA-ARS?s Scientific Manuscript database
The universal availability of the complete Tribolium castaneum genome sequence assembly and annotation and concomitant development of the versatile Tribolium genome browser, BeetleBase (http://beetlebase.org/) open new realms of possibility for stored-product pest control by greatly simplifying the...
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DOE Office of Scientific and Technical Information (OSTI.GOV)
Gmitter, Jr., Fred; Rokhsar, Dan
Fred Gmitter from the University of Florida on "Applications of Genome-based Science in Shaping the Future of the World's Citrus Industries" at the 7th Annual Genomics of Energy & Environment Meeting on March 21, 2012 in Walnut Creek, California.
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Gmitter, Jr., Fred; Rokhsar, Dan
2018-02-16
Fred Gmitter from the University of Florida on "Applications of Genome-based Science in Shaping the Future of the World's Citrus Industries" at the 7th Annual Genomics of Energy & Environment Meeting on March 21, 2012 in Walnut Creek, California.
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ERIC Educational Resources Information Center
Schachter, Ron
2008-01-01
For more than a year, the debate, press coverage, and buzz in Washington, D.C., have swirled over whether someone so different--and so relatively inexperienced--can deliver sweeping change. And presidential hopeful Barack Obama hasn't been the only one receiving that kind of unrelenting scrutiny. This article describes Michelle Rhee who became…
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Theobroma cacao: A genetically integrated physical map and genome-scale comparative synteny analysis
USDA-ARS?s Scientific Manuscript database
A comprehensive integrated genomic framework is considered a centerpiece of genomic research. In collaboration with the USDA-ARS (SHRS) and Mars Inc., the Clemson University Genomics Institute (CUGI) has developed a genetically anchored physical map of the T. cacao genome. Three BAC libraries contai...
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36 CFR 1253.4 - Washington National Records Center.
Code of Federal Regulations, 2010 CFR
2010-07-01
... 36 Parks, Forests, and Public Property 3 2010-07-01 2010-07-01 false Washington National Records Center. 1253.4 Section 1253.4 Parks, Forests, and Public Property NATIONAL ARCHIVES AND RECORDS ADMINISTRATION PUBLIC AVAILABILITY AND USE LOCATION OF RECORDS AND HOURS OF USE § 1253.4 Washington National...
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Federal Register 2010, 2011, 2012, 2013, 2014
2012-07-06
... DEPARTMENT OF COMMERCE International Trade Administration University of Connecticut, et al... Constitution Avenue NW., Washington, DC. Docket Number: 12-022. Applicant: University of Connecticut, Storrs...: See notice at 77 FR 32943, June 4, 2012. Docket Number: 12-023. Applicant: Howard Hughes Medical...
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Deep whole-genome sequencing of 90 Han Chinese genomes.
Lan, Tianming; Lin, Haoxiang; Zhu, Wenjuan; Laurent, Tellier Christian Asker Melchior; Yang, Mengcheng; Liu, Xin; Wang, Jun; Wang, Jian; Yang, Huanming; Xu, Xun; Guo, Xiaosen
2017-09-01
characterization of a large number of low-frequency, novel variants. This will be a valuable resource for promoting Chinese genetics research and medical development. Additionally, it will provide a valuable supplement to the 1000 Genomes Project, as well as to other human genome projects. © The Authors 2017. Published by Oxford University Press.
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Clarke, Laura; Fairley, Susan; Zheng-Bradley, Xiangqun; Streeter, Ian; Perry, Emily; Lowy, Ernesto; Tassé, Anne-Marie; Flicek, Paul
2017-01-04
The International Genome Sample Resource (IGSR; http://www.internationalgenome.org) expands in data type and population diversity the resources from the 1000 Genomes Project. IGSR represents the largest open collection of human variation data and provides easy access to these resources. IGSR was established in 2015 to maintain and extend the 1000 Genomes Project data, which has been widely used as a reference set of human variation and by researchers developing analysis methods. IGSR has mapped all of the 1000 Genomes sequence to the newest human reference (GRCh38), and will release updated variant calls to ensure maximal usefulness of the existing data. IGSR is collecting new structural variation data on the 1000 Genomes samples from long read sequencing and other technologies, and will collect relevant functional data into a single comprehensive resource. IGSR is extending coverage with new populations sequenced by collaborating groups. Here, we present the new data and analysis that IGSR has made available. We have also introduced a new data portal that increases discoverability of our data-previously only browseable through our FTP site-by focusing on particular samples, populations or data sets of interest. © The Author(s) 2016. Published by Oxford University Press on behalf of Nucleic Acids Research.
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The Small Nuclear Genomes of Selaginella Are Associated with a Low Rate of Genome Size Evolution.
Baniaga, Anthony E; Arrigo, Nils; Barker, Michael S
2016-06-03
The haploid nuclear genome size (1C DNA) of vascular land plants varies over several orders of magnitude. Much of this observed diversity in genome size is due to the proliferation and deletion of transposable elements. To date, all vascular land plant lineages with extremely small nuclear genomes represent recently derived states, having ancestors with much larger genome sizes. The Selaginellaceae represent an ancient lineage with extremely small genomes. It is unclear how small nuclear genomes evolved in Selaginella We compared the rates of nuclear genome size evolution in Selaginella and major vascular plant clades in a comparative phylogenetic framework. For the analyses, we collected 29 new flow cytometry estimates of haploid genome size in Selaginella to augment publicly available data. Selaginella possess some of the smallest known haploid nuclear genome sizes, as well as the lowest rate of genome size evolution observed across all vascular land plants included in our analyses. Additionally, our analyses provide strong support for a history of haploid nuclear genome size stasis in Selaginella Our results indicate that Selaginella, similar to other early diverging lineages of vascular land plants, has relatively low rates of genome size evolution. Further, our analyses highlight that a rapid transition to a small genome size is only one route to an extremely small genome. © The Author 2016. Published by Oxford University Press on behalf of the Society for Molecular Biology and Evolution.
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Correlation between genome reduction and bacterial growth.
Kurokawa, Masaomi; Seno, Shigeto; Matsuda, Hideo; Ying, Bei-Wen
2016-12-01
Genome reduction by removing dispensable genomic sequences in bacteria is commonly used in both fundamental and applied studies to determine the minimal genetic requirements for a living system or to develop highly efficient bioreactors. Nevertheless, whether and how the accumulative loss of dispensable genomic sequences disturbs bacterial growth remains unclear. To investigate the relationship between genome reduction and growth, a series of Escherichia coli strains carrying genomes reduced in a stepwise manner were used. Intensive growth analyses revealed that the accumulation of multiple genomic deletions caused decreases in the exponential growth rate and the saturated cell density in a deletion-length-dependent manner as well as gradual changes in the patterns of growth dynamics, regardless of the growth media. Accordingly, a perspective growth model linking genome evolution to genome engineering was proposed. This study provides the first demonstration of a quantitative connection between genomic sequence and bacterial growth, indicating that growth rate is potentially associated with dispensable genomic sequences. © The Author 2016. Published by Oxford University Press on behalf of Kazusa DNA Research Institute.
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Update on RefSeq microbial genomes resources.
Tatusova, Tatiana; Ciufo, Stacy; Federhen, Scott; Fedorov, Boris; McVeigh, Richard; O'Neill, Kathleen; Tolstoy, Igor; Zaslavsky, Leonid
2015-01-01
NCBI RefSeq genome collection http://www.ncbi.nlm.nih.gov/genome represents all three major domains of life: Eukarya, Bacteria and Archaea as well as Viruses. Prokaryotic genome sequences are the most rapidly growing part of the collection. During the year of 2014 more than 10,000 microbial genome assemblies have been publicly released bringing the total number of prokaryotic genomes close to 30,000. We continue to improve the quality and usability of the microbial genome resources by providing easy access to the data and the results of the pre-computed analysis, and improving analysis and visualization tools. A number of improvements have been incorporated into the Prokaryotic Genome Annotation Pipeline. Several new features have been added to RefSeq prokaryotic genomes data processing pipeline including the calculation of genome groups (clades) and the optimization of protein clusters generation using pan-genome approach. Published by Oxford University Press on behalf of Nucleic Acids Research 2014. This work is written by US Government employees and is in the public domain in the US.
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Evaluation of the Washington nighttime seat belt enforcement program.
DOT National Transportation Integrated Search
2017-04-01
The Washington Traffic Safety Commission (WTSC) and the National Highway Traffic Safety Administration (NHTSA) : conducted a high-visibility Nighttime Seat Belt Enforcement (NTSBE) program in Washington. The two-year program : followed the basic Clic...
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Winsor, Geoffrey L; Griffiths, Emma J; Lo, Raymond; Dhillon, Bhavjinder K; Shay, Julie A; Brinkman, Fiona S L
2016-01-04
The Pseudomonas Genome Database (http://www.pseudomonas.com) is well known for the application of community-based annotation approaches for producing a high-quality Pseudomonas aeruginosa PAO1 genome annotation, and facilitating whole-genome comparative analyses with other Pseudomonas strains. To aid analysis of potentially thousands of complete and draft genome assemblies, this database and analysis platform was upgraded to integrate curated genome annotations and isolate metadata with enhanced tools for larger scale comparative analysis and visualization. Manually curated gene annotations are supplemented with improved computational analyses that help identify putative drug targets and vaccine candidates or assist with evolutionary studies by identifying orthologs, pathogen-associated genes and genomic islands. The database schema has been updated to integrate isolate metadata that will facilitate more powerful analysis of genomes across datasets in the future. We continue to place an emphasis on providing high-quality updates to gene annotations through regular review of the scientific literature and using community-based approaches including a major new Pseudomonas community initiative for the assignment of high-quality gene ontology terms to genes. As we further expand from thousands of genomes, we plan to provide enhancements that will aid data visualization and analysis arising from whole-genome comparative studies including more pan-genome and population-based approaches. © The Author(s) 2015. Published by Oxford University Press on behalf of Nucleic Acids Research.
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Sablok, Gaurav; Chen, Ting-Wen; Lee, Chi-Ching; Yang, Chi; Gan, Ruei-Chi; Wegrzyn, Jill L; Porta, Nicola L; Nayak, Kinshuk C; Huang, Po-Jung; Varotto, Claudio; Tang, Petrus
2017-06-01
Organelle genomes are widely thought to have arisen from reduction events involving cyanobacterial and archaeal genomes, in the case of chloroplasts, or α-proteobacterial genomes, in the case of mitochondria. Heterogeneity in base composition and codon preference has long been the subject of investigation of topics ranging from phylogenetic distortion to the design of overexpression cassettes for transgenic expression. From the overexpression point of view, it is critical to systematically analyze the codon usage patterns of the organelle genomes. In light of the importance of codon usage patterns in the development of hyper-expression organelle transgenics, we present ChloroMitoCU, the first-ever curated, web-based reference catalog of the codon usage patterns in organelle genomes. ChloroMitoCU contains the pre-compiled codon usage patterns of 328 chloroplast genomes (29,960 CDS) and 3,502 mitochondrial genomes (49,066 CDS), enabling genome-wide exploration and comparative analysis of codon usage patterns across species. ChloroMitoCU allows the phylogenetic comparison of codon usage patterns across organelle genomes, the prediction of codon usage patterns based on user-submitted transcripts or assembled organelle genes, and comparative analysis with the pre-compiled patterns across species of interest. ChloroMitoCU can increase our understanding of the biased patterns of codon usage in organelle genomes across multiple clades. ChloroMitoCU can be accessed at: http://chloromitocu.cgu.edu.tw/. © The Author 2017. Published by Oxford University Press on behalf of Kazusa DNA Research Institute.
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Washington Headquarters Services
Status OPM Status: Open Open Main Navigation Home Our Services Our Customers Our People Our Leaders Our Organization Contact Us CAC Site Navigation Customers Employees Our Services Our Customers Our People Our facilities in the Washington, DC area. Read more about Our Customers Our People A picture with the left edge
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» OSPO Home » DOC » NOAA » NESDIS » OSPO NOAA Office of Satellite and Product Operations EMWIN GEONETCAST Americas GOES DCS LRIT NOAA Satellite Conferences NOAASIS SARSAT Products Atmosphere - Satellite Services Division - Office of Satellite Data Processing and Distribution Washington Volcanic Ash
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The Modern Synthesis in the Light of Microbial Genomics.
Booth, Austin; Mariscal, Carlos; Doolittle, W Ford
2016-09-08
We review the theoretical implications of findings in genomics for evolutionary biology since the Modern Synthesis. We examine the ways in which microbial genomics has influenced our understanding of the last universal common ancestor, the tree of life, species, lineages, and evolutionary transitions. We conclude by advocating a piecemeal toolkit approach to evolutionary biology, in lieu of any grand unified theory updated to include microbial genomics.
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Addition of a breeding database in the Genome Database for Rosaceae
Evans, Kate; Jung, Sook; Lee, Taein; Brutcher, Lisa; Cho, Ilhyung; Peace, Cameron; Main, Dorrie
2013-01-01
Breeding programs produce large datasets that require efficient management systems to keep track of performance, pedigree, geographical and image-based data. With the development of DNA-based screening technologies, more breeding programs perform genotyping in addition to phenotyping for performance evaluation. The integration of breeding data with other genomic and genetic data is instrumental for the refinement of marker-assisted breeding tools, enhances genetic understanding of important crop traits and maximizes access and utility by crop breeders and allied scientists. Development of new infrastructure in the Genome Database for Rosaceae (GDR) was designed and implemented to enable secure and efficient storage, management and analysis of large datasets from the Washington State University apple breeding program and subsequently expanded to fit datasets from other Rosaceae breeders. The infrastructure was built using the software Chado and Drupal, making use of the Natural Diversity module to accommodate large-scale phenotypic and genotypic data. Breeders can search accessions within the GDR to identify individuals with specific trait combinations. Results from Search by Parentage lists individuals with parents in common and results from Individual Variety pages link to all data available on each chosen individual including pedigree, phenotypic and genotypic information. Genotypic data are searchable by markers and alleles; results are linked to other pages in the GDR to enable the user to access tools such as GBrowse and CMap. This breeding database provides users with the opportunity to search datasets in a fully targeted manner and retrieve and compare performance data from multiple selections, years and sites, and to output the data needed for variety release publications and patent applications. The breeding database facilitates efficient program management. Storing publicly available breeding data in a database together with genomic and genetic data will
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75 FR 20776 - Security Zone; Potomac River, Washington Channel, Washington, DC
Federal Register 2010, 2011, 2012, 2013, 2014
2010-04-21
.... Coast Guard Commandant's Change of Command ceremony from 6 a.m. through 5 p.m. on May 25, 2010. Entry.... Basis and Purpose The Coast Guard will conduct a Change of Command ceremony at Fort McNair in Washington... the U.S. Coast Guard Commandant's Change of Command ceremony. Due to the catastrophic impact a...
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Drivers' use of marijuana in Washington state : traffic tech.
DOT National Transportation Integrated Search
2016-08-01
In July 2014, Washington State allowed legal sales of : recreational marijuana. Working with the Washington : Traffic Safety Commission, NHTSA assisted the State in : conducting a roadside study to examine the prevalence : of marijuana use before and...
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The Washington Library Network
ERIC Educational Resources Information Center
Franklin, Ralph W.; MacDonald, Clarice I.
1976-01-01
The objectives of the Washington Library Network (WLN) are 1) statewide sharing of resources among all types of libraries, 2) economically meeting the information demands of all citizens of the state, and 3) centralized computer-communication systems for bibliographic services. (Author)
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DOE Office of Scientific and Technical Information (OSTI.GOV)
Courteau, J.
1991-10-11
Since the Genome Project began several years ago, a plethora of databases have been developed or are in the works. They range from the massive Genome Data Base at Johns Hopkins University, the central repository of all gene mapping information, to small databases focusing on single chromosomes or organisms. Some are publicly available, others are essentially private electronic lab notebooks. Still others limit access to a consortium of researchers working on, say, a single human chromosome. An increasing number incorporate sophisticated search and analytical software, while others operate as little more than data lists. In consultation with numerous experts inmore » the field, a list has been compiled of some key genome-related databases. The list was not limited to map and sequence databases but also included the tools investigators use to interpret and elucidate genetic data, such as protein sequence and protein structure databases. Because a major goal of the Genome Project is to map and sequence the genomes of several experimental animals, including E. coli, yeast, fruit fly, nematode, and mouse, the available databases for those organisms are listed as well. The author also includes several databases that are still under development - including some ambitious efforts that go beyond data compilation to create what are being called electronic research communities, enabling many users, rather than just one or a few curators, to add or edit the data and tag it as raw or confirmed.« less
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DOE Office of Scientific and Technical Information (OSTI.GOV)
Myles Axton; Francis Collins; Charles Rotimi
2004-11-01
This supplement has its origins on May 15, 2003, when the National Human Genome Center at Howard University held a small but important workshop in Washington DC. The workshop, Human Genome Variation and 'Race', and this special issue of Nature Genetics were proposed by scientists at Howard University and financially supported by the Genome Programs of the US Department of Energy, through its Office of Science; the Irving Harris Foundation; the National Institutes of Health, through the National Human Genome Research Institute; and Howard University. As summarized by Francis Collins, director of the National Human Genome Research Institute, the workshopmore » focused on several key questions: ''What does the current body of scientific information say about the connections among race, ethnicity, genetics and health? What remains unknown? What additional research is needed? How can this information be applied to benefit human health? How might this information be applied in nonmedical settings? How can we adopt policies that will achieve beneficial societal outcomes?'' This supplement, supported by the Department of Energy through a grant to Howard University, contains articles based on the presentations at this workshop.« less
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Washington Monument Grounds, U.S. Reservation 2, Fiveacres, northeast section of ...
Washington Monument Grounds, U.S. Reservation 2, Five-acres, northeast section of the 106-acre,Washington Monument Grounds. Bounded by Constitution Avenue to the north, Madison Drive to the south, 14th Street to the east, and 15th Street to the West, Washington, District of Columbia, DC
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Pellicer, Jaume; Kelly, Laura J; Leitch, Ilia J; Zomlefer, Wendy B; Fay, Michael F
2014-03-01
• Since the occurrence of giant genomes in angiosperms is restricted to just a few lineages, identifying where shifts towards genome obesity have occurred is essential for understanding the evolutionary mechanisms triggering this process. • Genome sizes were assessed using flow cytometry in 79 species and new chromosome numbers were obtained. Phylogenetically based statistical methods were applied to infer ancestral character reconstructions of chromosome numbers and nuclear DNA contents. • Melanthiaceae are the most diverse family in terms of genome size, with C-values ranging more than 230-fold. Our data confirmed that giant genomes are restricted to tribe Parideae, with most extant species in the family characterized by small genomes. Ancestral genome size reconstruction revealed that the most recent common ancestor (MRCA) for the family had a relatively small genome (1C = 5.37 pg). Chromosome losses and polyploidy are recovered as the main evolutionary mechanisms generating chromosome number change. • Genome evolution in Melanthiaceae has been characterized by a trend towards genome size reduction, with just one episode of dramatic DNA accumulation in Parideae. Such extreme contrasting profiles of genome size evolution illustrate the key role of transposable elements and chromosome rearrangements in driving the evolution of plant genomes. © 2013 The Authors. New Phytologist © 2013 New Phytologist Trust.
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75 FR 10446 - Security Zone; Potomac River, Washington Channel, Washington, DC
Federal Register 2010, 2011, 2012, 2013, 2014
2010-03-08
... during the U.S. Coast Guard Commandant's Change of Command ceremony from 6 a.m. through 5 p.m. on May 25... Purpose The Coast Guard will conduct a Change of Command ceremony at Fort McNair in Washington, DC. To... the U.S. Coast Guard Commandant's Change of Command ceremony. Due to the catastrophic impact a...
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ERIC Educational Resources Information Center
Hadley, Arthur Twining
1909-01-01
This bulletin contains a report prepared by President Hadley of Yale University on the facilities for advanced study and research in the offices of the National Government at Washington. Especial interest attaches to this publication. It sets forth, in compact form, information which has frequently been sought by institutions and individuals…
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Assessing the lumber manufacturing sector in western Washington
Jean M. Daniels
2010-01-01
The production structure of the lumber manufacturing sector in western Washington was investigated using a translog cost function with capital. labor, and sawlog inputs. Analyses were performed with a panel data set of biennial observations from 1972 to 2002 on a cross section of 16 western Washington counties. Production structure was examined using Allen and...
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Washington: Hanford Nuclear Reservation
Atmospheric Science Data Center
2014-05-15
... is seen wending its way around the area, and the Snake River branches off to the right. According to Idaho's National Interagency Fire ... NASA's Jet Propulsion Laboratory, Pasadena, CA, for NASA's Science Mission Directorate, Washington, D.C. The Terra spacecraft is managed ...
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Washington State School Finance, 1999: A Special Focus on Teacher Salaries.
ERIC Educational Resources Information Center
Plecki, Margaret L.
This paper provides current information about the funding of Washington's K-12 school finance system. Schools in Washington State derive most of their revenues from state sources. In response to a 1977 court ruling, 'Seattle v. State of Washington', the state assumed responsibility for funding "basic education" for a "uniform system…
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School District-University Cooperation in Competency-Based Inservice Teacher Education.
ERIC Educational Resources Information Center
Grunewald, Robert N.
This article describes a jointly planned and jointly evaluated course offered through Washington State University General Extension. The purpose of the course was to improve instruction in elementary classrooms through use of competency-based training materials (Minicourses) from the Far West Laboratory for Educational Research and Development.…
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GenPlay Multi-Genome, a tool to compare and analyze multiple human genomes in a graphical interface.
Lajugie, Julien; Fourel, Nicolas; Bouhassira, Eric E
2015-01-01
Parallel visualization of multiple individual human genomes is a complex endeavor that is rapidly gaining importance with the increasing number of personal, phased and cancer genomes that are being generated. It requires the display of variants such as SNPs, indels and structural variants that are unique to specific genomes and the introduction of multiple overlapping gaps in the reference sequence. Here, we describe GenPlay Multi-Genome, an application specifically written to visualize and analyze multiple human genomes in parallel. GenPlay Multi-Genome is ideally suited for the comparison of allele-specific expression and functional genomic data obtained from multiple phased genomes in a graphical interface with access to multiple-track operation. It also allows the analysis of data that have been aligned to custom genomes rather than to a standard reference and can be used as a variant calling format file browser and as a tool to compare different genome assembly, such as hg19 and hg38. GenPlay is available under the GNU public license (GPL-3) from http://genplay.einstein.yu.edu. The source code is available at https://github.com/JulienLajugie/GenPlay. © The Author 2014. Published by Oxford University Press. All rights reserved. For Permissions, please e-mail: journals.permissions@oup.com.
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ERIC Educational Resources Information Center
Peterson, Elaine; Carr, Mary M.
Three colleges in the state of Washington--Gonzaga College (Crosby Library), Whitworth College, and Eastern Washington University--received grants from the Fred Meyer Charitable Trust and the Library Services and Construction Act to facilitate coordinated collection development in the areas of education and business/economics, so that their…
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VIEW OF NOS. 217 AND 219 WASHINGTON AVENUE LOOKING NORTHEAST, ...
VIEW OF NOS. 217 AND 219 WASHINGTON AVENUE LOOKING NORTHEAST, SHOWING WEST FACADES - Apollo Iron & Steel Works, Company Housing, West of Washington & Lincoln Avenues, Vandergrift, Westmoreland County, PA
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Habitat fragmentation and the persistence of lynx populations in Washington state
Gary M Koehler; Benjamin T. Maletzke; Jeff A. Von Kienast; Keith B. Aubry; Robert B. Wielgus; Robert H. Naney
2008-01-01
Lynx (Lynx canadensis) occur in the northern counties of Washington state, USA; however, current distribution and status of lynx in Washington are poorly understood. During winters 2002-2004 we snow-tracked lynx for 155 km within a 211-km2 area in northern Washington, to develop a model of lynx-habitat relationships that we...
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University Nanosatellite Program ION-F Constellation
NASA Technical Reports Server (NTRS)
Swenson, Charles; Fullmer, Rees; Redd, Frank
2002-01-01
The Space Engineering program at Utah State University has developed a small satellite, known as USUSat, under funding from AFOSR, AFRL, NASA and Utah State University's Space Dynamics Laboratory. This satellite was designed and significantly manufactured by students in the Mechanical and Aerospace Engineering and the Electrical and Computer Engineering Departments within the College of Engineering. USUSat is one of three spacecraft being designed for the Ionospheric Observation Nanosatellite Formation (ION- F). This formation comprises three 15 kg. spacecraft designed and built in cooperation by Utah State University, University of Washington, and Virginia Polytechnic Institute. The ION-F satellites are being designed and built by students at the three universities, with close coordination to insure compatibility for launch, deployment, and the formation flying mission. The JON-F mission is part of the U.S. Air Force Research Laboratory (AFRL) University Nanosatellite Program, which provides technology development and demonstrations for the TechSat2l Program. The University Nanosatellite Program involves 10 universities building nanosatellites for a launch in 2004 on two separate space shuttle missions. Additional support for the formation flying demonstration has been provided by NASA's Goddard Space Flight Center.
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Louis, Alexandra; Nguyen, Nga Thi Thuy; Muffato, Matthieu; Roest Crollius, Hugues
2015-01-01
The Genomicus web server (http://www.genomicus.biologie.ens.fr/genomicus) is a visualization tool allowing comparative genomics in four different phyla (Vertebrate, Fungi, Metazoan and Plants). It provides access to genomic information from extant species, as well as ancestral gene content and gene order for vertebrates and flowering plants. Here we present the new features available for vertebrate genome with a focus on new graphical tools. The interface to enter the database has been improved, two pairwise genome comparison tools are now available (KaryoView and MatrixView) and the multiple genome comparison tools (PhyloView and AlignView) propose three new kinds of representation and a more intuitive menu. These new developments have been implemented for Genomicus portal dedicated to vertebrates. This allows the analysis of 68 extant animal genomes, as well as 58 ancestral reconstructed genomes. The Genomicus server also provides access to ancestral gene orders, to facilitate evolutionary and comparative genomics studies, as well as computationally predicted regulatory interactions, thanks to the representation of conserved non-coding elements with their putative gene targets. © The Author(s) 2014. Published by Oxford University Press on behalf of Nucleic Acids Research.
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Genome-based approaches to develop vaccines against bacterial pathogens.
Serruto, Davide; Serino, Laura; Masignani, Vega; Pizza, Mariagrazia
2009-05-26
Bacterial infectious diseases remain the single most important threat to health worldwide. Although conventional vaccinology approaches were successful in conferring protection against several diseases, they failed to provide efficacious solutions against many others. The advent of whole-genome sequencing changed the way to think about vaccine development, enabling the targeting of possible vaccine candidates starting from the genomic information of a single bacterial isolate, with a process named reverse vaccinology. As the genomic era progressed, reverse vaccinology has evolved with a pan-genome approach and multi-strain genome analysis became fundamental for the design of universal vaccines. This review describes the applications of genome-based approaches in the development of new vaccines against bacterial pathogens.
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Manuwal, David Allen; Carter, Harry R.; Zimmerman, Tara; Orthmeyer, Dennis L.
2001-01-01
, Dixon Field Station), Humboldt State University, and University of California (Santa Cruz). Colony surveys in Oregon and Washington were conducted mainly by the U.S. Fish and Wildlife Service (Oregon Coast National Wildlife Refuge and Washington Maritime National Wildlife Refuges). In British Columbia, most work from the 1960s to 1995 was sponsored and conducted by the Canadian Wildlife Service and Royal British Columbia Museum.
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A low emission vehicle procurement approach for Washington state
NASA Astrophysics Data System (ADS)
McCoy, G. A.; Lyons, J. K.; Ware, G.
1992-06-01
The Clean Air Washington Act of 1991 directs the Department of Ecology to establish a clean-fuel vehicle standard. The Department of General Administration shall purchase vehicles based on this standard beginning in the Fall of 1992. The following summarizes the major issues effecting vehicle emissions and their regulation, and present a methodology for procuring clean-fuel vehicles for the State of Washington. Washington State's air quality problems are much less severe than in other parts of the country such as California, the East Coast and parts of the Mid West. Ozone, which is arguably the dominant air quality problem in the US, is a recent and relatively minor issue in Washington. Carbon monoxide (CO) represents a more immediate problem in Washington, with most of the state's urban areas exceeding national CO air quality standards. Since the mid-1960's, vehicle tailpipe hydrocarbon and carbon monoxide emissions have been reduced by 96 percent relative to precontrol vehicles. Nitrogen oxide emissions have been reduced by 76 percent. Emissions from currently available vehicles are quite low with respect to in-place exhaust emission standards. Cold-start emissions constitute about 75 percent of the total emissions measured with the Federal Test Procedure used to certify motor vehicles. There is no currently available 'inherently clean burning fuel'. In 1991, 3052 vehicles were purchased under Washington State contract. Provided that the same number are acquired in 1993, the state will need to purchase 915 vehicles which meet the definition of a 'clean-fueled vehicle'.
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Greening America's Capitals - Washington, DC
This Greening America's Capitals report describes design options for the Anacostia Metro station in Washington, DC, that could help people feel safer and more comfortable walking to and from the station.
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Kravatsky, Yuri V; Chechetkin, Vladimir R; Tchurikov, Nikolai A; Kravatskaya, Galina I
2015-02-01
The broad class of tasks in genetics and epigenetics can be reduced to the study of various features that are distributed over the genome (genome tracks). The rapid and efficient processing of the huge amount of data stored in the genome-scale databases cannot be achieved without the software packages based on the analytical criteria. However, strong inhomogeneity of genome tracks hampers the development of relevant statistics. We developed the criteria for the assessment of genome track inhomogeneity and correlations between two genome tracks. We also developed a software package, Genome Track Analyzer, based on this theory. The theory and software were tested on simulated data and were applied to the study of correlations between CpG islands and transcription start sites in the Homo sapiens genome, between profiles of protein-binding sites in chromosomes of Drosophila melanogaster, and between DNA double-strand breaks and histone marks in the H. sapiens genome. Significant correlations between transcription start sites on the forward and the reverse strands were observed in genomes of D. melanogaster, Caenorhabditis elegans, Mus musculus, H. sapiens, and Danio rerio. The observed correlations may be related to the regulation of gene expression in eukaryotes. Genome Track Analyzer is freely available at http://ancorr.eimb.ru/. © The Author 2015. Published by Oxford University Press on behalf of Kazusa DNA Research Institute.
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View of inside second floor stairwell of George Washington Junior ...
View of inside second floor stairwell of George Washington Junior High School looking at double doors, facing north. - George Washington Junior High School, 707 Columbus Drive, Tampa, Hillsborough County, FL
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ERIC Educational Resources Information Center
Washington State Office of Community Development, Olympia.
Conceived as a state-supported community-sponsored program for families, strengthened by business and service organization support, and designed to work with local educational, child care, and social service agencies, Washington State's Early Childhood Education and Assistance Program (ECEAP, pronounced e-cap) provides a "whole child"…
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NemaPath: online exploration of KEGG-based metabolic pathways for nematodes
Wylie, Todd; Martin, John; Abubucker, Sahar; Yin, Yong; Messina, David; Wang, Zhengyuan; McCarter, James P; Mitreva, Makedonka
2008-01-01
Background Nematode.net is a web-accessible resource for investigating gene sequences from parasitic and free-living nematode genomes. Beyond the well-characterized model nematode C. elegans, over 500,000 expressed sequence tags (ESTs) and nearly 600,000 genome survey sequences (GSSs) have been generated from 36 nematode species as part of the Parasitic Nematode Genomics Program undertaken by the Genome Center at Washington University School of Medicine. However, these sequencing data are not present in most publicly available protein databases, which only include sequences in Swiss-Prot. Swiss-Prot, in turn, relies on GenBank/Embl/DDJP for predicted proteins from complete genomes or full-length proteins. Description Here we present the NemaPath pathway server, a web-based pathway-level visualization tool for navigating putative metabolic pathways for over 30 nematode species, including 27 parasites. The NemaPath approach consists of two parts: 1) a backend tool to align and evaluate nematode genomic sequences (curated EST contigs) against the annotated Kyoto Encyclopedia of Genes and Genomes (KEGG) protein database; 2) a web viewing application that displays annotated KEGG pathway maps based on desired confidence levels of primary sequence similarity as defined by a user. NemaPath also provides cross-referenced access to nematode genome information provided by other tools available on Nematode.net, including: detailed NemaGene EST cluster information; putative translations; GBrowse EST cluster views; links from nematode data to external databases for corresponding synonymous C. elegans counterparts, subject matches in KEGG's gene database, and also KEGG Ontology (KO) identification. Conclusion The NemaPath server hosts metabolic pathway mappings for 30 nematode species and is available on the World Wide Web at . The nematode source sequences used for the metabolic pathway mappings are available via FTP , as provided by the Genome Center at Washington University
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173. WASHINGTON ST. ALEXANDRIA AND MEMORIAL FOR THE CONFEDERATE DEAD ...
173. WASHINGTON ST. ALEXANDRIA AND MEMORIAL FOR THE CONFEDERATE DEAD LOOKING NORTH. - George Washington Memorial Parkway, Along Potomac River from McLean to Mount Vernon, VA, Mount Vernon, Fairfax County, VA
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DOE Office of Scientific and Technical Information (OSTI.GOV)
Shih, Patrick
2012-03-22
Patrick Shih, representing both the University of California, Berkeley and JGI, gives a talk titled "CyanoGEBA: A Better Understanding of Cynobacterial Diversity through Large-scale Genomics" at the JGI 7th Annual Users Meeting: Genomics of Energy & Environment Meeting on March 22, 2012 in Walnut Creek, California.
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Shih, Patrick
2018-01-10
Patrick Shih, representing both the University of California, Berkeley and JGI, gives a talk titled "CyanoGEBA: A Better Understanding of Cynobacterial Diversity through Large-scale Genomics" at the JGI 7th Annual Users Meeting: Genomics of Energy & Environment Meeting on March 22, 2012 in Walnut Creek, California.
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NASA Astrophysics Data System (ADS)
Halversen, C.; McDonnell, J. D.; Apple, J. K.; Weiss, E. L.
2016-02-01
Two university courses, 1) Promoting Climate Literacy and 2) Climate and Data Literacy, developed by the University of California Berkeley provide faculty across the country with course materials to help their students delve into the science underlying global environmental change. The courses include culturally responsive content, such as indigenous and place-based knowledge, and examine how people learn and consequently, how we should teach and communicate science. Promoting Climate Literacy was developed working with Scripps Institution of Oceanography, University of Washington, and Western Washington University. Climate and Data Literacy was developed with Rutgers University and Padilla Bay National Estuarine Research Reserve, WA. The Climate and Data Literacy course also focuses on helping students in science majors participating in U-Teach programs and students in pre-service teacher education programs gain skills in using real and near-real time data through engaging in investigations using web-based and locally-relevant data resources. The course helps these students understand and apply the scientific practices, disciplinary concepts and big ideas described in the Framework for K-12 Science Education and the Next Generation Science Standards (NGSS). This course focuses on students interested in teaching middle school science for three reasons: (1) teachers often have relatively weak understandings of the practices of science, and of complex Earth systems science and climate change; (2) the concepts that underlie climate change align well with the NGSS; and (3) middle school is a critical time for promoting student interest in science and for recruitment to STEM careers and lifelong climate literacy. This course is now being field tested in a number of U-Teach programs including Florida State University, Louisiana State University, as well as pre-service teacher education programs at California State University East Bay, and Western Washington University
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Ensembl comparative genomics resources.
Herrero, Javier; Muffato, Matthieu; Beal, Kathryn; Fitzgerald, Stephen; Gordon, Leo; Pignatelli, Miguel; Vilella, Albert J; Searle, Stephen M J; Amode, Ridwan; Brent, Simon; Spooner, William; Kulesha, Eugene; Yates, Andrew; Flicek, Paul
2016-01-01
Evolution provides the unifying framework with which to understand biology. The coherent investigation of genic and genomic data often requires comparative genomics analyses based on whole-genome alignments, sets of homologous genes and other relevant datasets in order to evaluate and answer evolutionary-related questions. However, the complexity and computational requirements of producing such data are substantial: this has led to only a small number of reference resources that are used for most comparative analyses. The Ensembl comparative genomics resources are one such reference set that facilitates comprehensive and reproducible analysis of chordate genome data. Ensembl computes pairwise and multiple whole-genome alignments from which large-scale synteny, per-base conservation scores and constrained elements are obtained. Gene alignments are used to define Ensembl Protein Families, GeneTrees and homologies for both protein-coding and non-coding RNA genes. These resources are updated frequently and have a consistent informatics infrastructure and data presentation across all supported species. Specialized web-based visualizations are also available including synteny displays, collapsible gene tree plots, a gene family locator and different alignment views. The Ensembl comparative genomics infrastructure is extensively reused for the analysis of non-vertebrate species by other projects including Ensembl Genomes and Gramene and much of the information here is relevant to these projects. The consistency of the annotation across species and the focus on vertebrates makes Ensembl an ideal system to perform and support vertebrate comparative genomic analyses. We use robust software and pipelines to produce reference comparative data and make it freely available. Database URL: http://www.ensembl.org. © The Author(s) 2016. Published by Oxford University Press.
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An assessment of interstate safety investment properties in Washington state.
DOT National Transportation Integrated Search
2014-12-01
The Washington State Department of Transportation (WSDOT) commissioned the current study, targeting the entire interstate : mainline network in Washington State, to provide strategic direction to multi-biennial investment interstate locations that of...
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Post-Genome Era Pedagogy: How a BS Biotechnology Program Benefits the Liberal Arts Institution
ERIC Educational Resources Information Center
Eden, Peter
2005-01-01
Genomics profoundly affects society, because genome sequence information is widely used in such areas as genetic testing, genomic medicine/vaccine development, and so forth. Therefore, a responsibility to modernize science curricula exists for "post-genome era" educators. At my university, we developed a BS biotechnology program within a…
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Key Facts about Higher Education in Washington: 2009-10
ERIC Educational Resources Information Center
Washington Higher Education Coordinating Board, 2010
2010-01-01
First published in 2002, "Key Facts about Higher Education in Washington" provides valuable information on the ways higher education serves the state and its people. The most current data and information available is presented throughout this report to highlight the "Key Facts" about Washington's postsecondary institutions,…
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Expanding Access and Opportunity: The Washington State Achievers Scholarship
ERIC Educational Resources Information Center
O'Brien, Colleen
2011-01-01
In 2001, the Bill & Melinda Gates Foundation launched the multi-year, multi-million dollar Washington State Achievers Scholarship program. Concerned about disparities in college participation for low-income students in the state of Washington versus their wealthier peers, the Gates Foundation partnered with the College Success Foundation…
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Expanding Access and Opportunity: The Washington State Achievers Program
ERIC Educational Resources Information Center
Ramsey, Jennifer; Gorgol, Laura
2010-01-01
In 2001, the Bill & Melinda Gates Foundation launched a 10-year, multi-million dollar initiative, the Washington State Achievers Program (WSA), to increase opportunities for low-income students to attend postsecondary institutions in Washington State. The Bill & Melinda Gates Foundation granted funds to the College Success Foundation…
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Interactive Exploration on Large Genomic Datasets.
Tu, Eric
2016-01-01
The prevalence of large genomics datasets has made the the need to explore this data more important. Large sequencing projects like the 1000 Genomes Project [1], which reconstructed the genomes of 2,504 individuals sampled from 26 populations, have produced over 200TB of publically available data. Meanwhile, existing genomic visualization tools have been unable to scale with the growing amount of larger, more complex data. This difficulty is acute when viewing large regions (over 1 megabase, or 1,000,000 bases of DNA), or when concurrently viewing multiple samples of data. While genomic processing pipelines have shifted towards using distributed computing techniques, such as with ADAM [4], genomic visualization tools have not. In this work we present Mango, a scalable genome browser built on top of ADAM that can run both locally and on a cluster. Mango presents a combination of different optimizations that can be combined in a single application to drive novel genomic visualization techniques over terabytes of genomic data. By building visualization on top of a distributed processing pipeline, we can perform visualization queries over large regions that are not possible with current tools, and decrease the time for viewing large data sets. Mango is part of the Big Data Genomics project at University of California-Berkeley [25] and is published under the Apache 2 license. Mango is available at https://github.com/bigdatagenomics/mango.
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Forest fire weather in western Oregon and western Washington in 1957.
Owen P. Cramer
1957-01-01
Severity of 1957 fire weather west of the Cascade Range summit in Oregon and Washington was near the average of the previous 10 years. The season (April 1 through October 31) was slightly more severe than 1956 in western Oregon and about the same as 1956 in western Washington. Spring fire weather was near average severity in both western Washington and western Oregon....
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Self-revegetation of disturbed ground in the deserts of Nevada and Washington
DOE Office of Scientific and Technical Information (OSTI.GOV)
Rickard, W.H.; Sauer, R.H.
1982-01-01
Plant cover established without purposeful soil preparation or seeding was measured on ground disturbed by plowing in Washington and by aboveground nuclear explosions in Nevada. After a time lapse of three decades in Washington and two decades in Nevada, fewer species were self-established on the disturbed ground than the nearby undisturbed ground. Alien annual plants were the dominants on the disturbed ground. Cheatgrass (Bromus tectorum) dominated abandoned fields in Washington, and filaree (Erodium cicutarium) dominated disturbed ground in Nevada. Perennial grasses and shrubs appeared to be more successful as invaders in Nevada than in Washington. This distinction is attributed tomore » the superior competitive ability of cheatgrass in Washington.« less
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First international E. coli genome meeting
DOE Office of Scientific and Technical Information (OSTI.GOV)
Not Available
1992-12-31
This volume is a collection of abstracts of oral presentations and poster sessions of studies reported at the First International E. Coli Genome Meeting, held September 10-14, 1992 at the University of Wisconsin.
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First international E. coli genome meeting
DOE Office of Scientific and Technical Information (OSTI.GOV)
Not Available
1992-01-01
This volume is a collection of abstracts of oral presentations and poster sessions of studies reported at the First International E. Coli Genome Meeting, held September 10-14, 1992 at the University of Wisconsin.
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Nakagawa, So; Takahashi, Mahoko Ueda
2016-01-01
In mammals, approximately 10% of genome sequences correspond to endogenous viral elements (EVEs), which are derived from ancient viral infections of germ cells. Although most EVEs have been inactivated, some open reading frames (ORFs) of EVEs obtained functions in the hosts. However, EVE ORFs usually remain unannotated in the genomes, and no databases are available for EVE ORFs. To investigate the function and evolution of EVEs in mammalian genomes, we developed EVE ORF databases for 20 genomes of 19 mammalian species. A total of 736,771 non-overlapping EVE ORFs were identified and archived in a database named gEVE (http://geve.med.u-tokai.ac.jp). The gEVE database provides nucleotide and amino acid sequences, genomic loci and functional annotations of EVE ORFs for all 20 genomes. In analyzing RNA-seq data with the gEVE database, we successfully identified the expressed EVE genes, suggesting that the gEVE database facilitates studies of the genomic analyses of various mammalian species.Database URL: http://geve.med.u-tokai.ac.jp. © The Author(s) 2016. Published by Oxford University Press.
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Photocopy of original blackandwhite silver gelatin print, VIEW FROM WASHINGTON ...
Photocopy of original black-and-white silver gelatin print, VIEW FROM WASHINGTON MONUMENT, October 3, 1929, photography Commercial Photo - Internal Revenue Service Headquarters Building, 1111 Constitution Avenue Northwest, Washington, District of Columbia, DC
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PERSPECTIVE VIEW OF COMPANYBUILT HOUSING ON EAST SIDE OF WASHINGTON ...
PERSPECTIVE VIEW OF COMPANY-BUILT HOUSING ON EAST SIDE OF WASHINGTON AVENUE, VIEWED FROM FRANKLIN AVENUE LOOKING NORTH - Apollo Iron & Steel Works, Company Housing, West of Washington & Lincoln Avenues, Vandergrift, Westmoreland County, PA
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Washington | Solar Research | NREL
. Utilities offer varied loans and incentives to their renewable energy customers. Net Metering All customer is allowed for up to 100 kW per customer Interconnection Washington's adopted standardized Department of Revenue and local utilities Customer-owned renewable energy generation systems can receive
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Uchiyama, Ikuo; Mihara, Motohiro; Nishide, Hiroyo; Chiba, Hirokazu
2015-01-01
The microbial genome database for comparative analysis (MBGD) (available at http://mbgd.genome.ad.jp/) is a comprehensive ortholog database for flexible comparative analysis of microbial genomes, where the users are allowed to create an ortholog table among any specified set of organisms. Because of the rapid increase in microbial genome data owing to the next-generation sequencing technology, it becomes increasingly challenging to maintain high-quality orthology relationships while allowing the users to incorporate the latest genomic data available into an analysis. Because many of the recently accumulating genomic data are draft genome sequences for which some complete genome sequences of the same or closely related species are available, MBGD now stores draft genome data and allows the users to incorporate them into a user-specific ortholog database using the MyMBGD functionality. In this function, draft genome data are incorporated into an existing ortholog table created only from the complete genome data in an incremental manner to prevent low-quality draft data from affecting clustering results. In addition, to provide high-quality orthology relationships, the standard ortholog table containing all the representative genomes, which is first created by the rapid classification program DomClust, is now refined using DomRefine, a recently developed program for improving domain-level clustering using multiple sequence alignment information. © The Author(s) 2014. Published by Oxford University Press on behalf of Nucleic Acids Research.
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Pop, Mihai
2018-04-27
University of Maryland's Mihai Pop on Genome Assembly Forensics: Metrics for Assessing Assembly Correctness at the Metagenomics Informatics Challenges Workshop held at the DOE JGI on October 12-13, 2011.
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NASA Astrophysics Data System (ADS)
Korpelainen, Helena
2004-11-01
This paper first introduces our present knowledge of the origin of mitochondria and chloroplasts, and the organization and inheritance patterns of their genomes, and then carries on to review the evolutionary processes influencing mitochondrial and chloroplast genomes. The differences in evolutionary phenomena between the nuclear and cytoplasmic genomes are highlighted. It is emphasized that varying inheritance patterns and copy numbers among different types of genomes, and the potential advantage achieved through the transfer of many cytoplasmic genes to the nucleus, have important implications for the evolution of nuclear, mitochondrial and chloroplast genomes. Cytoplasmic genes transferred to the nucleus have joined the more strictly controlled genetic system of the nuclear genome, including also sexual recombination, while genes retained within the cytoplasmic organelles can be involved in selection and drift processes both within and among individuals. Within-individual processes can be either intra- or intercellular. In the case of heteroplasmy, which is attributed to mutations or biparental inheritance, within-individual selection on cytoplasmic DNA may provide a mechanism by which the organism can adapt rapidly. The inheritance of cytoplasmic genomes is not universally maternal. The presence of a range of inheritance patterns indicates that different strategies have been adopted by different organisms. On the other hand, the variability occasionally observed in the inheritance mechanisms of cytoplasmic genomes reduces heritability and increases environmental components in phenotypic features and, consequently, decreases the potential for adaptive evolution.
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Building a Prosperous Economy. Washington's Community and Technical Colleges
ERIC Educational Resources Information Center
Washington State Board for Community and Technical Colleges, 2014
2014-01-01
Washington's community and technical colleges are a collective, powerful, unmatched resource for advancing prosperity through education. These 34 colleges not only connect with employers in the regions where they operate, but also with each other through common programs--like advanced manufacturing and allied health--that align with Washington's…
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Too-Comfortable Strangers: Cultural Association among the Sephardim of Washington, D.C.
ERIC Educational Resources Information Center
Fredman, Ruth Gruber
The power of the symbol "Sephardic" to foster community association is extremely problematical in the Washington, D.C., context. Washington's Sephardic population is heterogeneous with respect to generation, self-definition, and culture. Complicating the situation is the nature of Washington itself, which in turn is inextricably linked…
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12. VISTA SOUTHWEST ON NEW HAMPSHIRE AVENUE TO WASHINGTON CIRCLE ...
12. VISTA SOUTHWEST ON NEW HAMPSHIRE AVENUE TO WASHINGTON CIRCLE FROM RESERVATION NO. 140 AT THE INTERSECTION OF NEW HAMPSHIRE AVENUE, M, AND 21ST STREETS, NW. - New Hampshire Avenue, Washington, District of Columbia, DC
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2. View of Mainline elevated structure, parallel to Washington Street, ...
2. View of Mainline elevated structure, parallel to Washington Street, crossing over the Massachusetts Turnpike and the B&A R.R. tracks - looking North. - Boston Elevated Railway, Elevated Mainline, Washington Street, Boston, Suffolk County, MA
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Washington state freight system resiliency.
DOT National Transportation Integrated Search
2009-01-01
The economic viability and well-being of Washington State is significantly influenced by the freight : transportation system serving the region. An increased understanding of the vulnerability of this freight : system to natural disasters, weather, t...
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Robinson, Gene
2018-02-05
The U.S. Department of Energy Joint Genome Institute (JGI) invited scientists interested in the application of genomics to bioenergy and environmental issues, as well as all current and prospective users and collaborators, to attend the annual DOE JGI Genomics of Energy & Environment Meeting held March 22-24, 2011 in Walnut Creek, CA. The emphasis of this meeting was on the genomics of renewable energy strategies, carbon cycling, environmental gene discovery, and engineering of fuel-producing organisms. The meeting features presentations by leading scientists advancing these topics. Gene Robinson of the University of Illinois on Genomic and Systems Biology Analyses of Social Behavior at the 6th Annual Genomics of Energy & Environment Meeting on March 23, 2011.
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Theory of microbial genome evolution
NASA Astrophysics Data System (ADS)
Koonin, Eugene
Bacteria and archaea have small genomes tightly packed with protein-coding genes. This compactness is commonly perceived as evidence of adaptive genome streamlining caused by strong purifying selection in large microbial populations. In such populations, even the small cost incurred by nonfunctional DNA because of extra energy and time expenditure is thought to be sufficient for this extra genetic material to be eliminated by selection. However, contrary to the predictions of this model, there exists a consistent, positive correlation between the strength of selection at the protein sequence level, measured as the ratio of nonsynonymous to synonymous substitution rates, and microbial genome size. By fitting the genome size distributions in multiple groups of prokaryotes to predictions of mathematical models of population evolution, we show that only models in which acquisition of additional genes is, on average, slightly beneficial yield a good fit to genomic data. Thus, the number of genes in prokaryotic genomes seems to reflect the equilibrium between the benefit of additional genes that diminishes as the genome grows and deletion bias. New genes acquired by microbial genomes, on average, appear to be adaptive. Evolution of bacterial and archaeal genomes involves extensive horizontal gene transfer and gene loss. Many microbes have open pangenomes, where each newly sequenced genome contains more than 10% `ORFans', genes without detectable homologues in other species. A simple, steady-state evolutionary model reveals two sharply distinct classes of microbial genes, one of which (ORFans) is characterized by effectively instantaneous gene replacement, whereas the other consists of genes with finite, distributed replacement rates. These findings imply a conservative estimate of at least a billion distinct genes in the prokaryotic genomic universe.
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Genome Island: A Virtual Science Environment in Second Life
ERIC Educational Resources Information Center
Clark, Mary Anne
2009-01-01
Mary Anne CLark describes the organization and uses of Genome Island, a virtual laboratory complex constructed in Second Life. Genome Island was created for teaching genetics to university undergraduates but also provides a public space where anyone interested in genetics can spend a few minutes, or a few hours, interacting with genetic…
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Washington Community Colleges Factbook.
ERIC Educational Resources Information Center
Meier, Terre; Story, Sherie
Detailed information on the 27 state-supported community colleges in Washington is presented in six sections. The first section, containing general information, describes the state system organization, lists the individual colleges, and reviews the roles of state agencies and presents a history of the system. A section on student information…
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75 FR 71139 - Land Acquisitions; Puyallup Tribe of Washington
Federal Register 2010, 2011, 2012, 2013, 2014
2010-11-22
... Auditor, in Pierce County, Washington. Except that portion of Lot 3 conveyed to the State of Washington by Deeds recorded under Auditor's file number 689865 and 689858. Together with the East half of the... amendment of Short Plat Nos. 8502210395 and 8403080186, filed with the Pierce County Auditor, in Pierce...
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36 CFR § 1253.4 - Washington National Records Center.
Code of Federal Regulations, 2013 CFR
2013-07-01
... 36 Parks, Forests, and Public Property 3 2013-07-01 2012-07-01 true Washington National Records Center. § 1253.4 Section § 1253.4 Parks, Forests, and Public Property NATIONAL ARCHIVES AND RECORDS... National Records Center. Washington National Records Center is located at 4205 Suitland Road, Suitland, MD...
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National Leaders in Innovation. Washington's Community and Technical Colleges
ERIC Educational Resources Information Center
Washington State Board for Community and Technical Colleges, 2015
2015-01-01
Washington's community and technical colleges set a national example for innovative policies, practices and research for student success. Washington's community and technical college system ranks 12th in the nation for graduation rates, and 7th for certificates and degrees produced. Olympic College and Renton Technical College in March 2015 were…
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36 CFR 910.13 - Urban design of Washington, DC.
Code of Federal Regulations, 2010 CFR
2010-07-01
... CORPORATION GENERAL GUIDELINES AND UNIFORM STANDARDS FOR URBAN PLANNING AND DESIGN OF DEVELOPMENT WITHIN THE PENNSYLVANIA AVENUE DEVELOPMENT AREA Urban Planning and Design Concerns § 910.13 Urban design of Washington, DC... 36 Parks, Forests, and Public Property 3 2010-07-01 2010-07-01 false Urban design of Washington...
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36 CFR 910.13 - Urban design of Washington, DC.
Code of Federal Regulations, 2011 CFR
2011-07-01
... CORPORATION GENERAL GUIDELINES AND UNIFORM STANDARDS FOR URBAN PLANNING AND DESIGN OF DEVELOPMENT WITHIN THE PENNSYLVANIA AVENUE DEVELOPMENT AREA Urban Planning and Design Concerns § 910.13 Urban design of Washington, DC... 36 Parks, Forests, and Public Property 3 2011-07-01 2011-07-01 false Urban design of Washington...
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11. Photocopy of photograph by Commission of Fine Arts, Washington, ...
11. Photocopy of photograph by Commission of Fine Arts, Washington, DC. Date and photographer unknown. CLOSE UP OF ARMILLARY SPHERE - Meridian Hill Park, Bounded by Fifteenth, Sixteenth, Euclid & W Streets, Northwest, Washington, District of Columbia, DC
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76 FR 52566 - Drawbridge Operation Regulations; Anacostia River, Washington, DC
Federal Register 2010, 2011, 2012, 2013, 2014
2011-08-23
... Lift Bridge across the Anacostia River, mile 3.4, at Washington, DC. This deviation will test a change... regulations for the CSX Railroad Vertical Lift Bridge, across the Anacostia River, mile 3.4, at Washington, DC...
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1989-05-25
Boulder, Colorado : Westview Press, 1977); and Kathleen J. Turner, Lyndon Johnson’s Dual War: Vietnam and the Press (Chicago: University of Chicago Press...Interpreted the Crisis of Tet 1968 in Vietnam and Washington. 2 volumes (Boulder, Colorado : Westview Press, 1977), vol. 1, p. 706 [hereafter referred...addressed the nation on the situation in Vietnam. Recognizing that neither the Congress nor the American people would tolerate the reintroduction of any
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DeMets, David L; Fleming, Thomas R; Geller, Gail; Ransohoff, David F
2017-08-01
When there have been substantial failures by institutional leadership in their oversight responsibility to protect research integrity, the public should demand that these be recognized and addressed by the institution itself, or the funding bodies. This commentary discusses a case of research failures in developing genomic predictors for cancer risk assessment and treatment at a leading university. In its review of this case, the Office of Research Integrity, an agency within the US Department of Health and Human Services, focused their report entirely on one individual faculty member and made no comment on the institution's responsibility and its failure to provide adequate oversight and investigation. These actions missed an important opportunity to emphasize the institution's critical responsibilities in oversight of research integrity and the importance of institutional transparency and accountability.
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DOT National Transportation Integrated Search
1997-04-01
This implementation agreement was adopted by the Washington State Department of Ecology and the Washington State Department of Transportation. It requires that the agencies work together in dealing with short term modifications of water quality requi...
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Logging residue in Washington, Oregon, California: volume and characteristics.
James O. Howard
1973-01-01
This report makes available data on the volume and characteristics of logging residue resulting from 1969 logging operations in Oregon, Washington, and California. The results indicate highest volumes of logging residue are found in the Douglas-fir region of western Oregon and western Washington. Average gross volume of residue in this region ranged...
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77 FR 15787 - Washington; Major Disaster and Related Determinations
Federal Register 2010, 2011, 2012, 2013, 2014
2012-03-16
... declaration of a major disaster for the State of Washington (FEMA-4056-DR), dated March 5, 2012, and related determinations. DATES: Effective Date: March 5, 2012. FOR FURTHER INFORMATION CONTACT: Peggy Miller, Office of... determined that the damage in certain areas of the State of Washington resulting from a severe winter storm...
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The Washington National Cathedral: A Place to Gather Together
ERIC Educational Resources Information Center
Groce, Eric; Groce, Robin
2011-01-01
Washington, D.C. is a city widely recognized for its monuments, memorials, and landmarks. Visitors are routinely drawn to the great sites that mark the nation's history such as the Vietnam Veterans Memorial, Arlington National Cemetery, the Lincoln Memorial, and the Washington Memorial, among others. One site that is often overlooked is the…
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Educator Supply and Demand in Washington State. 2004 Report
ERIC Educational Resources Information Center
Lashway, Larry; Maloney, Rick; Hathaway, Randy; Bryant, B. J.
2005-01-01
This report describes the findings of the third Educator Supply and Demand Research study in the State of Washington. The intent of these Washington studies is to provide data to inform and shape decisions and activities in the following ways: (1) Provide useful information for educational policymakers, including the legislature, the State Board…
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Trends and determinants of cycling in the Washington, DC region.
DOT National Transportation Integrated Search
2011-01-01
This report analyzes cycling trends, policies, and commuting in the Washington, DC area. The analysis is divided into two parts. : Part 1 focuses on cycling trends and policies in Washington (DC), Alexandria (VA), Arlington County (VA), Fairfax Count...
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Washington Community Colleges Factbook.
ERIC Educational Resources Information Center
Meier, Terre
The 109 tables and graphs in this six-chapter factbook present a statistical profile of the Washington Community College System for Fall 1979. Chapter I presents background information on the history and organization of the 27 state-supported colleges. Chapter II outlines data on annual and quarterly enrollments from 1969 through 1979; student…
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Alternative Fuels for Washington's School Buses: A Report to the Washington State Legislature.
ERIC Educational Resources Information Center
Lyons, John Kim; McCoy, Gilbert A.
This document presents findings of a study that evaluated the use of both propane and compressed natural gas as alternative fuels for Washington State school buses. It discusses air quality improvement actions by state- and federal-level regulators and summarizes vehicle design, development, and commercialization activities by all major engine,…
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A genomic view of food-related and probiotic Enterococcus strains.
Bonacina, Julieta; Suárez, Nadia; Hormigo, Ricardo; Fadda, Silvina; Lechner, Marcus; Saavedra, Lucila
2017-02-01
The study of enterococcal genomes has grown considerably in recent years. While special attention is paid to comparative genomic analysis among clinical relevant isolates, in this study we performed an exhaustive comparative analysis of enterococcal genomes of food origin and/or with potential to be used as probiotics. Beyond common genetic features, we especially aimed to identify those that are specific to enterococcal strains isolated from a certain food-related source as well as features present in a species-specific manner. Thus, the genome sequences of 25 Enterococcus strains, from 7 different species, were examined and compared. Their phylogenetic relationship was reconstructed based on orthologous proteins and whole genomes. Likewise, markers associated with a successful colonization (bacteriocin genes and genomic islands) and genome plasticity (phages and clustered regularly interspaced short palindromic repeats) were investigated for lifestyle specific genetic features. At the same time, a search for antibiotic resistance genes was carried out, since they are of big concern in the food industry. Finally, it was possible to locate 1617 FIGfam families as a core proteome universally present among the genera and to determine that most of the accessory genes code for hypothetical proteins, providing reasonable hints to support their functional characterization. © The Author 2016. Published by Oxford University Press on behalf of Kazusa DNA Research Institute.
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77 FR 33307 - Drawbridge Operation Regulation; Lake Washington Ship Canal, Seattle, WA
Federal Register 2010, 2011, 2012, 2013, 2014
2012-06-06
... Operation Regulation; Lake Washington Ship Canal, Seattle, WA AGENCY: Coast Guard, DHS. ACTION: Notice of... operating schedule that governs the Montlake Bridge across the Lake Washington Ship Canal, mile 5.2, at... crosses the Lake Washington Ship Canal at mile 5.2 and while in the closed position provides 30 feet of...
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76 FR 69131 - Drawbridge Operation Regulation; Lake Washington Ship Canal, Seattle, WA
Federal Register 2010, 2011, 2012, 2013, 2014
2011-11-08
... Operation Regulation; Lake Washington Ship Canal, Seattle, WA AGENCY: Coast Guard, DHS. ACTION: Notice of... Bridge across the Lake Washington Ship Canal, mile 0.1, at Seattle, WA. The deviation is necessary to... Bascule Bridge across the Lake Washington Ship Canal, mile 0.1, for vessel traffic for a 14 day period to...
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1. WASHINGTON SQUARE IN CENTER, LOOKING SOUTHWEST. CURTIS PUBLISHING COMPANY ...
1. WASHINGTON SQUARE IN CENTER, LOOKING SOUTHWEST. CURTIS PUBLISHING COMPANY IS AT RIGHT. THE BUILDING IN FRONT OF PHOTO IS THE PENN MUTUAL LIFE INSURANCE COMPANY - Washington Square Area Study, Sixth, Seventh, Walnut & Locust Streets, Philadelphia, Philadelphia County, PA
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Genomics of Extinct and Endangered Species (2011 JGI User Meeting)
Shuster, Stephen
2018-02-13
The U.S. Department of Energy Joint Genome Institute (JGI) invited scientists interested in the application of genomics to bioenergy and environmental issues, as well as all current and prospective users and collaborators, to attend the annual DOE JGI Genomics of Energy & Environment Meeting held March 22-24, 2011 in Walnut Creek, Calif. The emphasis of this meeting was on the genomics of renewable energy strategies, carbon cycling, environmental gene discovery, and engineering of fuel-producing organisms. The meeting features presentations by leading scientists advancing these topics. Stephen Shuster of Penn State University gives a presentation on "Genomics of Extinct and Endangered Species" at the 6th annual Genomics of Energy & Environment Meeting on March 23, 2011.
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Residential Energy Efficiency Potential: Washington
DOE Office of Scientific and Technical Information (OSTI.GOV)
Wilson, Eric J
Energy used by Washington single-family homes that can be saved through cost-effective improvements. Prepared by Eric Wilson and Noel Merket, NREL, and Erin Boyd, U.S. Department of Energy Office of Energy Policy and Systems Analysis.
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Financial Roadblocks to Renewing and Enhancing Washington's Public Schools.
ERIC Educational Resources Information Center
Theobald, Neil D.
Many states are trying to balance interests in school between taxpayers' concerns and providing students with a good education. Washington is trying to overcome these problems and renew and enhance its public schools. Three court decisions in the late 1970s and early 1980s set strict constraints within which Washington's school funding system must…
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The Proving Grounds: School "Rheeform" in Washington, D.C.
ERIC Educational Resources Information Center
Dingerson, Leigh
2010-01-01
Washington, D.C., is leading the transformation of urban public education across the country--at least according to "Time" magazine, which featured D.C. Schools Chancellor Michelle Rhee on its cover, wearing black and holding a broom. But there is nothing remarkably visionary going on in Washington. The model of school reform that is…
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78 FR 67295 - Amendment of Class E Airspace; Washington, KS
Federal Register 2010, 2011, 2012, 2013, 2014
2013-11-12
... Airport has made reconfiguration necessary for standard instrument approach procedures and for the safety and management of Instrument Flight Rule (IFR) operations at the airport. Geographic coordinates are... approach procedures at Washington County Memorial Airport, Washington, KS. Airspace configuration is...